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Sample records for accidental release prevention

  1. Preventing and controlling accidental gas releases

    Moskowitz, P. D.; Fthenakis, V. M.; Kalb, P. D.

    1988-07-01

    Toxic, flammable, and explosive gases may be used in photovoltaic cell research laboratories and in commercial manufacturing facilities. Accidental release of these materials can present hazards to life and property. Accidents can arise from a variety of mechanical and human related failures. These can occur from the time materials are received at the loading dock of the facility to the time treated gases are discharged to the atmosphere through a stack. Each type of initiating event may require a different control approach. These may range from the training and certification of plant workers charged with the handling of gas cylinder hookups to installation of emergency pollution control systems. Since engineering options for controlling released materials are limited, emphasis should be placed on administrative and engineering approaches for preventing such accidents. These are likely to be the most effective approaches for protecting life and property.

  2. 78 FR 66321 - Approval of North Dakota Request for Partial Delegation of Prevention of Accidental Release...

    2013-11-05

    ... the public to improve accident prevention and emergency response practices. The North Dakota... Prevention and Risk Management Programs for Chemical Accident Release Prevention.'' See 40 CFR 68.130. The... six thousand gallons. NDCC 19-20.2 contains engineering requirements for tanks, valve fittings,...

  3. 49 CFR 192.751 - Prevention of accidental ignition.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Prevention of accidental ignition. 192.751 Section 192.751 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.751 Prevention...

  4. Numerical simulation of industrial and accidental release formation and transport

    Piskunov, V.N.; Aloyan, A.A.; Gerasimov, V.M.; Pinaev, V.S.; Golubev, A.I.; Yanilkin, Yu.V.; Ivanov, N.V.; Nikonov, S.N.; Kharchenko, A.I. [and others

    1995-05-01

    Statement of work for contract 006 {open_quotes}Mathematical simulation of industrial and accidental release formation and transport{close_quotes} implies that the final result of the activity within this task will be VNIIEF developed techniques which will provide for the prediction of the post-accidental environment. Report [1] presents the description of physical models and calculation techniques which were chosen by VNIIEF to accomplish this task. These techniques were analysed for their capabilities, the areas of their application were defined, modifications within contract 006 were described, the results of test and methodical calculations were presented. Moreover, the experimental data were analysed over the source parameters and contamination measurements which can be used in the comparison with the calculation results. Based an these data this report compares the calculation results obtained with VNIIEF calculation techniques with the LANL-presented experimental results. The calculations which statements and results are given in section 1, included the following processes: explosion cloud ascent dynamics and jet release origin; aerosols kinetics in the release source including composite particle origin in the explosion cloud caused by radioactive substance sorption an the soil particles; contaminant transport in atmosphere and their in-site fallout due to the accidental explosions and fires; atmospheric flow dynamics and industrial contamination transfer over the complicated terrain. The calculated results were compared with the experimental data. Section 2 presents the parameters for a typical source in the explosion accidents based an the experimental results and calculated data from Section 1, as well as contamination patterns were calculated with basic technique {open_quotes}Prognosis{close_quotes}.

  5. Accidental Continuous Releases from Coal Processing in Semi-Confined Environment

    Bruno Fabiano

    2013-09-01

    Full Text Available Notwithstanding the enforcement of ATEX EU Directives (94/9/EC of 23 March 1994 and safety management system application, explosions in the coal sector still claim lives and cause huge economic losses. Even a consolidated activity like coke dry distillation allows the opportunity of preventing explosion risk connected to fugitive emissions of coke oven gas. Considering accidental releases under semi-confined conditions, a simplified mathematical approach to the maximum allowed gaseous build-up is developed on the basis of the intrinsic hazards of the released compound. The results will help identifying and assessing low rate release consequences therefore to set-up appropriate prevention and control measures. The developed methodology was tested at the real-scale and validated by numerical computational fluid dynamics (CFD simulations showing the effectiveness of the methodology to evaluate and mitigate the risk connected to confined hazardous releases.

  6. Individual dose due to radioactivity accidental release from fusion reactor.

    Nie, Baojie; Ni, Muyi; Wei, Shiping

    2017-04-05

    As an important index shaping the design of fusion safety system, evaluation of public radiation consequences have risen as a hot topic on the way to develop fusion energy. In this work, the comprehensive public early dose was evaluated due to unit gram tritium (HT/HTO), activated dust, activated corrosion products (ACPs) and activated gases accidental release from ITER like fusion reactor. Meanwhile, considering that we cannot completely eliminate the occurrence likelihood of multi-failure of vacuum vessel and tokamak building, we conservatively evaluated the public radiation consequences and environment restoration after the worst hypothetical accident preliminarily. The comparison results show early dose of different unit radioactivity release under different conditions. After further performing the radiation consequences, we find it possible that the hypothetical accident for ITER like fusion reactor would result in a level 6 accident according to INES, not appear level 7 like Chernobyl or Fukushima accidents. And from the point of environment restoration, we need at least 69 years for case 1 (1kg HTO and 1000kg dust release) and 34-52years for case 2 (1kg HTO and 10kg-100kg dust release) to wait the contaminated zone drop below the general public safety limit (1mSv per year) before it is suitable for human habitation.

  7. Accidental release of chlorine and its impact on urban areas

    El-Sheikh, H.A.; Badr, O.A.; El Kadi, H.M.; Hamoda, M.F. [United Arab Emirates Univ., Abu Dhabi (United Arab Emirates). Faculty of Engineering

    1995-12-31

    Among the possible scenarios of accidental releases of chlorine from high pressure cylinders, this paper considers a typical one for the analysis. The calculated transient mass flow rate of chlorine released from a one-tonne cylinder showed that such an accident takes about 10 minutes to evacuate the cylinder. However, the toxic effect in the surrounding atmosphere continues for a longer period (about 20 minutes). The size and location of the toxic cloud at ground level were predicted as functions of time using an EPA-based dispersion model. The results showed a growth of the toxic cloud for some time beyond which it started to decay. For the typical scenario considered in this study, the most dangerous situation generated a toxic cloud with dimensions of 4000 m and 600 m in the downwind and crosswind directions, respectively. A study of the effects of some meteorological parameters on the size and location of the toxic cloud at ground level was also conducted. In general, it was observed that enhancing atmospheric mixing produced larger toxic zones during the early stages of the release and caused an opposite effect during the later ones. This dynamic data was linked to a GIS environment and the time variant was represented using an animation technique for Al-Ain City, United Arab Emirates. Data base information related to physical urban characteristics and population was immediately obtained for the affected areas.

  8. Muertes por enfermedades cardiacas y accidentes cerebrovasculares prevenibles - (Preventable Deaths from Heart Disease and Stroke)

    2013-09-03

    Este podcast se basa en la edición de septiembre del 2013 del informe Signos Vitales de los CDC. Más de 800,000 personas en los Estados Unidos mueren cada año a causa de enfermedades cardiacas y accidentes cerebrovasculares. Aprenda cómo controlar todos los principales factores de riesgo.  Created: 9/3/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 9/3/2013.

  9. The radiological impact on the Greater London population of postulated accidental releases from the Sizewell PWR

    Kelly, G N; Charles, D; Hemming, C R

    1983-01-01

    This report contains an assessment of the radiological impact on the Greater London population of postulated accidental releases from the Sizewell PWR. Three of the degraded core accident releases postulated by the CEGB are analysed. The consequences, conditional upon each release, are evaluated in terms of the health impact on the exposed population and the impact of countermeasures taken to limit the exposure. Consideration is given to the risk to the Greater London population as a whole and to individuals within it. The consequences are evaluated using the NRPB code MARC (Methodology for Assessing Radiological Consequences). The results presented in this report are all conditional upon the occurrence of each release. In assessing the significance of the results, due account must be taken of the frequency with which such releases may be predicted to occur.

  10. Overview study of LNG release prevention and control systems

    Pelto, P.J.; Baker, E.G.; Holter, G.M.; Powers, T.B.

    1982-03-01

    The liquefied natural gas (LNG) industry employs a variety of release prevention and control techniques to reduce the likelihood and the consequences of accidental LNG releases. A study of the effectiveness of these release prevention and control systems is being performed. Reference descriptions for the basic types of LNG facilities were developed. Then an overview study was performed to identify areas that merit subsequent and more detailed analyses. The specific objectives were to characterize the LNG facilities of interest and their release prevention and control systems, identify possible weak links and research needs, and provide an analytical framework for subsequent detailed analyses. The LNG facilities analyzed include a reference export terminal, marine vessel, import terminal, peakshaving facility, truck tanker, and satellite facility. A reference description for these facilities, a preliminary hazards analysis (PHA), and a list of representative release scenarios are included. The reference facility descriptions outline basic process flows, plant layouts, and safety features. The PHA identifies the important release prevention operations. Representative release scenarios provide a format for discussing potential initiating events, effects of the release prevention and control systems, information needs, and potential design changes. These scenarios range from relatively frequent but low consequence releases to unlikely but large releases and are the principal basis for the next stage of analysis.

  11. Forecasting consequences of accidental release: how reliable are current assessment models

    Rohwer, P.S.; Hoffman, F.O.; Miller, C.W.

    1983-01-01

    This paper focuses on uncertainties in model output used to assess accidents. We begin by reviewing the historical development of assessment models and the associated interest in uncertainties as these evolutionary processes occurred in the United States. This is followed by a description of the sources of uncertainties in assessment calculations. Types of models appropriate for assessment of accidents are identified. A summary of results from our analysis of uncertainty is provided in results obtained with current methodology for assessing routine and accidental radionuclide releases to the environment. We conclude with discussion of preferred procedures and suggested future directions to improve the state-of-the-art of radiological assessments.

  12. Estimating accidental pollutant releases in the built environment from turbulent concentration signals

    Ben Salem, N.; Salizzoni, P.; Soulhac, L.

    2017-01-01

    We present an inverse atmospheric model to estimate the mass flow rate of an impulsive source of pollutant, whose position is known, from concentration signals registered at receptors placed downwind of the source. The originality of this study is twofold. Firstly, the inversion is performed using high-frequency fluctuating, i.e. turbulent, concentration signals. Secondly, the inverse algorithm is applied to a dispersion process within a dense urban canopy, at the district scale, and a street network model, SIRANERISK, is adopted. The model, which is tested against wind tunnel experiments, simulates the dispersion of short-duration releases of pollutant in different typologies of idealised urban geometries. Results allow us to discuss the reliability of the inverse model as an operational tool for crisis management and the risk assessments related to the accidental release of toxic and flammable substances.

  13. 36 CFR 1230.10 - Who is responsible for preventing the unlawful or accidental removal, defacing, alteration, or...

    2010-07-01

    ... MANAGEMENT UNLAWFUL OR ACCIDENTAL REMOVAL, DEFACING, ALTERATION, OR DESTRUCTION OF RECORDS § 1230.10 Who is... destruction, removal, alteration or defacement of records; (c) Implement and disseminate policies and... preventing the unlawful or accidental removal, defacing, alteration, or destruction of records?...

  14. Accidental ingestion of a barbed wire broach and its endoscopic retrieval: Prevention better than cure

    Rajashekar Mohan

    2011-01-01

    Full Text Available Ingestion of instruments is a potential complication that can occur during dental procedures. We report a case of accidental ingestion of an endodontic barbed wire broach during root canal treatment and its subsequent retrieval by endoscopic methods. Although prevention is the best approach, proper management of such an event is also crucial. The objective of this report is to draw attention to the potentially serious complications that can occur if preventive techniques are not practised, and to discuss the accepted guidelines for management of such an event.

  15. Modeling acute health risks associated with accidental releases of toxic gases

    Haskin, F.E.; Ding, C.; Summa, K.J. [Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Chemical and Nuclear Engineering; Young, M. [Sandia National Labs., Albuquerque, NM (United States). Accident Analysis and Consequence Assessment Dept.

    1996-09-01

    CHEM{_}MACCS has been developed from the radiological accident consequence code, MACCS, to perform probabilistic calculations of potential off-site consequences of the accidental atmospheric release of hazardous chemicals. The principal phenomena considered in CHEM{_}MACCS are atmospheric transport, mitigative actions based on dose projection, dose accumulation by a number of pathways, and early and latent health effects. CHEM{_}MACCS provides the following capabilities: (1) statistical weather sampling data (8,760 hourly data points per year), (2) population dose and health effect risk calculations based on site-specific population data, (3) health effects calculations including the consideration of potential site specific mitigative actions (evacuation and shielding), and (4) modeling of multiple release segments. Three different sample problems are contained in this report to show how to use CHEM{_}MACCS. Three test problems are run to compare CHEM{_}MACCS and D2PC. The doses versus the downwind centerline distances from the source for the given doses are in very close agreement.

  16. Game theory of pre-emptive vaccination before bioterrorism or accidental release of smallpox.

    Molina, Chai; Earn, David J D

    2015-06-06

    Smallpox was eradicated in the 1970s, but new outbreaks could be seeded by bioterrorism or accidental release. Substantial vaccine-induced morbidity and mortality make pre-emptive mass vaccination controversial, and if vaccination is voluntary, then there is a conflict between self- and group interests. This conflict can be framed as a tragedy of the commons, in which herd immunity plays the role of the commons, and free-riding (i.e. not vaccinating pre-emptively) is analogous to exploiting the commons. This game has been analysed previously for a particular post-outbreak vaccination scenario. We consider several post-outbreak vaccination scenarios and compare the expected increase in mortality that results from voluntary versus imposed vaccination. Below a threshold level of post-outbreak vaccination effort, expected mortality is independent of the level of response effort. A lag between an outbreak starting and a response being initiated increases the post-outbreak vaccination effort necessary to reduce mortality. For some post-outbreak vaccination scenarios, even modest response lags make it impractical to reduce mortality by increasing post-outbreak vaccination effort. In such situations, if decreasing the response lag is impossible, the only practical way to reduce mortality is to make the vaccine safer (greater post-outbreak vaccination effort leads only to fewer people vaccinating pre-emptively).

  17. The effectiveness of a multidisciplinary QI activity for accidental fall prevention: Staff compliance is critical

    Ohde Sachiko

    2012-07-01

    Full Text Available Abstract Background Accidental falls among inpatients are a substantial cause of hospital injury. A number of successful experimental studies on fall prevention have shown the importance and efficacy of multifactorial intervention, though success rates vary. However, the importance of staff compliance with these effective, but often time-consuming, multifactorial interventions has not been fully investigated in a routine clinical setting. The purpose of this observational study was to describe the effectiveness of a multidisciplinary quality improvement (QI activity for accidental fall prevention, with particular focus on staff compliance in a non-experimental clinical setting. Methods This observational study was conducted from July 2004 through December 2010 at St. Luke’s International Hospital in Tokyo, Japan. The QI activity for in-patient falls prevention consisted of: 1 the fall risk assessment tool, 2 an intervention protocol to prevent in-patient falls, 3 specific environmental safety interventions, 4 staff education, and 5 multidisciplinary healthcare staff compliance monitoring and feedback mechanisms. Results The overall fall rate was 2.13 falls per 1000 patient days (350/164331 in 2004 versus 1.53 falls per 1000 patient days (263/172325 in 2010, representing a significant decrease (p = 0.039. In the first 6 months, compliance with use of the falling risk assessment tool at admission was 91.5% in 2007 (3998/4368, increasing to 97.6% in 2010 (10564/10828. The staff compliance rate of implementing an appropriate intervention plan was 85.9% in 2007, increasing to 95.3% in 2010. Conclusion In our study we observed a substantial decrease in patient fall rates and an increase of staff compliance with a newly implemented falls prevention program. A systematized QI approach that closely involves, encourages, and educates healthcare staff at multiple levels is effective.

  18. Accidental benzene release risk assessment in an urban area using an atmospheric dispersion model

    Truong, Son C. H.; Lee, Myong-In; Kim, Ganghan; Kim, Dongmin; Park, Jong-Hwa; Choi, Sung-Deuk; Cho, Gi-Hyoug

    2016-11-01

    This study applied the American Meteorological Society and Environmental Protection Agency Regulatory Model (AERMOD) to assess the risk caused by an accidental release and dispersion of the toxic chemical benzene in the vicinity of a highly populated urban area. The modeling domain encompasses the Korean megacity of Ulsan, which includes two national industrial complexes and is characterized by a complex coastal terrain. Multiple AERMOD simulations were conducted for an assumed emission scenario using background wind data from August between 2009 and 2013. The series of experiments produced the spatial accident probability patterns for different concentration levels during daytime and nighttime scenarios based on the corresponding dominant wind patterns. This study further quantifies the potential accident risk based on the number of affected individuals by combining the accident probability with the indoor and outdoor population estimates. The chemical gas dispersion characteristics depend on various local meteorological conditions, such as the land-sea breeze direction, which alternates between daytime and nighttime, and the atmospheric stability. The results reveal that benzene dispersion affects a much larger area during the nighttime owing to the presence of a nocturnal stable boundary layer with significant temperature stratification. The affected area is smaller during the daytime owing to decreased stability and enhanced vertical mixing in the boundary layer. The results include a high degree of uncertainty during the nighttime owing to weak wind speeds and the lack of a prevailing wind direction, which impact the vulnerable area. However, vulnerable areas are more effectively identified during the daytime, when more consistent meteorological conditions exist. However, the potential risk becomes much lower during the nighttime owing to a substantial reduction of the outdoor population.

  19. Estimation of vulnerable zones due to accidental release of toxic materials resulting in dense gas clouds.

    Singh, M P; Mohan, M; Panwar, T S; Chopra, H V

    1991-09-01

    Heavy gas dispersion models have been developed at IIT (hereinafter referred as IIT heavy gas models I and II) with a view to estimate vulnerable zones due to accidental (both instantaneous and continuous, respectively) release of dense toxic material in the atmosphere. The results obtained from IIT heavy gas models have been compared with those obtained from the DEGADIS model [Dense Gas Dispersion Model, developed by Havens and Spicer (1985) for the U.S. Coast Guard] as well as with the observed data collected during the Burro Series, Maplin Sands, and Thorney Island field trials. Both of these models include relevant features of dense gas dispersion, viz., gravity slumping, air entrainment, cloud heating, and transition to the passive phase, etc. The DEGADIS model has been considered for comparing the performance of IIT heavy gas models in this study because it incorporates most of the physical processes of dense gas dispersion in an elaborate manner, and has also been satisfactorily tested against field observations. The predictions from IIT heavy gas models indicate a fairly similar trend to the observed values from Thorney Island, Burro Series, and Maplin experiments with a tendency toward overprediction. There is a good agreement between the prediction of IIT Heavy Gas models I and II with those from DEGADIS, except for the simulations of IIT heavy gas model-I pertaining to very large release quantities under highly stable atmospheric conditions. In summary, the performance of IIT heavy gas models have been found to be reasonably good both with respect to the limited field data available and various simulations (selected on the basis of relevant storages in the industries and prevalent meteorological conditions performed with DEGADIS). However, there is a scope of improvement in the IIT heavy gas models (viz., better formulation for entrainment, modification of coefficients, transition criteria, etc.). Further, isotons (nomograms) have been prepared by using

  20. Historical Doses from Tritiated Water and Tritiated Hydrogen Gas Released to the Atmosphere from Lawrence Livermore National Laboratory (LLNL). Part 5. Accidental Releases

    Peterson, S

    2007-08-15

    Over the course of fifty-three years, LLNL had six acute releases of tritiated hydrogen gas (HT) and one acute release of tritiated water vapor (HTO) that were too large relative to the annual releases to be included as part of the annual releases from normal operations detailed in Parts 3 and 4 of the Tritium Dose Reconstruction (TDR). Sandia National Laboratories/California (SNL/CA) had one such release of HT and one of HTO. Doses to the maximally exposed individual (MEI) for these accidents have been modeled using an equation derived from the time-dependent tritium model, UFOTRI, and parameter values based on expert judgment. All of these acute releases are described in this report. Doses that could not have been exceeded from the large HT releases of 1965 and 1970 were calculated to be 43 {micro}Sv (4.3 mrem) and 120 {micro}Sv (12 mrem) to an adult, respectively. Two published sets of dose predictions for the accidental HT release in 1970 are compared with the dose predictions of this TDR. The highest predicted dose was for an acute release of HTO in 1954. For this release, the dose that could not have been exceeded was estimated to have been 2 mSv (200 mrem), although, because of the high uncertainty about the predictions, the likely dose may have been as low as 360 {micro}Sv (36 mrem) or less. The estimated maximum exposures from the accidental releases were such that no adverse health effects would be expected. Appendix A lists all accidents and large routine puff releases that have occurred at LLNL and SNL/CA between 1953 and 2005. Appendix B describes the processes unique to tritium that must be modeled after an acute release, some of the time-dependent tritium models being used today, and the results of tests of these models.

  1. Long-term environmental fate of perfluorinated compounds after accidental release at Toronto airport.

    Awad, Emily; Zhang, Xianming; Bhavsar, Satyendra P; Petro, Steve; Crozier, Patrick W; Reiner, Eric J; Fletcher, Rachael; Tittlemier, Sheryl A; Braekevelt, Eric

    2011-10-01

    Perfluorooctane sulfonate (PFOS; a perfluorinated compound or PFC), its salts, and perfluorooctane sulfonyl fluoride have recently been listed in Annex B of the Stockholm Convention due to their widespread presence, persistence, and toxicity. Because of the persistent nature of PFCs, it is generally presumed that the impact of direct discharges of these chemicals on a receiving environment would be long-lasting. However, long-term environmental fate studies based on field measurements are rare. We examined spatial and long-term (9 year) temporal trends of PFCs in water, sediment, fish, and fish liver collected in 2003, 2006, and 2009 from 10 locations spanning ∼20 km in Etobicoke and Spring Creeks, where an accidental release of fire fighting foam containing PFOS from nearby Toronto International Airport occurred in 2000. Even a decade after the spill, sediment PFOS concentrations are still elevated in Spring Creek Pond which received the foam discharge; however, the major impact is relatively localized likely due to the stormwater management nature of the pond and the diluting effect of Etobicoke Creek. Fish and fish liver PFOS concentrations at a Spring Creek location downstream of Spring Creek Pond declined by about 70 and 85%, respectively, between 2003 and 2009. PFOS in water at locations further downstream in Etobicoke Creek have declined by >99.99% since the spill; however, the 2009 water and fish levels were ∼2-10 times higher than upstream locations likely due to the long-term impact of the spill as well as urbanization. The decrease in the upstream PFOS concentrations likely reflects the reduction of PFOS sources due to phased out production by 3M and regulations on the use of PFOS in fire fighting foams. Field-based sediment/water distribution coefficients (K(D)) and bioaccumulation factors (BAF) were calculated from environmental measurements. Log K(D) values were 0.54-1.65 for perfluoroalkyl sulfonates (PFASs) and 1.00-1.85 for

  2. Final Report: Safety of Plasma Components and Aerosol Transport During Hard Disruptions and Accidental Energy Release in Fusion Reactor

    Bourham, Mohamed A.; Gilligan, John G.

    1999-08-14

    Safety considerations in large future fusion reactors like ITER are important before licensing the reactor. Several scenarios are considered hazardous, which include safety of plasma-facing components during hard disruptions, high heat fluxes and thermal stresses during normal operation, accidental energy release, and aerosol formation and transport. Disruption events, in large tokamaks like ITER, are expected to produce local heat fluxes on plasma-facing components, which may exceed 100 GW/m{sup 2} over a period of about 0.1 ms. As a result, the surface temperature dramatically increases, which results in surface melting and vaporization, and produces thermal stresses and surface erosion. Plasma-facing components safety issues extends to cover a wide range of possible scenarios, including disruption severity and the impact of plasma-facing components on disruption parameters, accidental energy release and short/long term LOCA's, and formation of airborne particles by convective current transport during a LOVA (water/air ingress disruption) accident scenario. Study, and evaluation of, disruption-induced aerosol generation and mobilization is essential to characterize database on particulate formation and distribution for large future fusion tokamak reactor like ITER. In order to provide database relevant to ITER, the SIRENS electrothermal plasma facility at NCSU has been modified to closely simulate heat fluxes expected in ITER.

  3. Risk assessment, risk management and risk-based monitoring following a reported accidental release of poliovirus in Belgium, September to November 2014

    Duizer, Erwin; Rutjes, Saskia; de Roda Husman, Ana Maria; Schijven, Jack

    2016-01-01

    On 6 September 2014, the accidental release of 10(13) infectious wild poliovirus type 3 (WPV3) particles by a vaccine production plant in Belgium was reported. WPV3 was released into the sewage system and discharged directly to a wastewater treatment plant (WWTP) and subsequently into rivers that fl

  4. Partitioning of perfluorooctanesulfonate and perfluorohexanesulfonate in the aquatic environment after an accidental release of aqueous film forming foam at Schiphol Amsterdam Airport

    Kwadijk, C.J.A.F.; Kotterman, M.J.J.; Koelmans, A.A.

    2014-01-01

    In the summer of 2008, an accidental release of Aqueous Film Forming Foam (AFFF) took place at Schiphol Amsterdam Airport (The Netherlands). After the release, water, fish and sediment samples were collected and analyzed for perfluoroalkyl sulfonates (PFSA). In situ perfluorooctane sulfonate (PFOS)

  5. Comparison of the MARC and CRAC2 programs for assessing the radiological consequences of accidental releases of radioactive material

    Hemming, C R; Charles, D; Ostmeyer, R M

    1983-01-01

    This report describes a comparison of the MARC (Methodology for Assessing Radiological Consequences) and CRAC2 (Calculation of Reactor Accident Consequences, version 2) computer programs for assessing the radiological consequences of accidental releases of radioactive material. A qualitative comparison has been made of the features of the constituent sub-models of the two codes, and potentially the most important differences identified. The influence of these differences has been investigated quantitatively by comparison of the predictions of the two codes in a wide variety of circumstances. Both intermediate quantities and endpoints used as a measure of risk have been compared in order to separate the variables more clearly. The results indicate that, in general, the predictions of MARC and CRAC2 are in good agreement.

  6. A CASE STUDY OF CHLORINE TRANSPORT AND FATE FOLLOWING A LARGE ACCIDENTAL RELEASE

    Buckley, R.; Hunter, C.; Werth, D.; Whiteside, M.; Chen, K.; Mazzola, C.

    2012-08-01

    A train derailment that occurred in Graniteville, South Carolina during the early morning hours of 06 January, 2005 resulted in the prompt release of approximately 60 tons of chlorine to the environment. Comprehensive modeling of the transport and fate of this release was performed including the characterization of the initial three-phased chlorine release, a detailed determination of the local atmospheric conditions acting to generate, disperse, and deplete the chlorine vapor cloud, the establishment of physical exchange mechanisms between the airborne vapor and local surface waters, and local aquatic dilution and mixing.

  7. Design of a monitoring network over France in case of a radiological accidental release

    Abida, Rachid; Bocquet, Marc; Vercauteren, Nikki; Isnard, Olivier

    The Institute of Radiation Protection and Nuclear Safety (France) is planning the set-up of an automatic nuclear aerosol monitoring network over the French territory. Each of the stations will be able to automatically sample the air aerosol content and provide activity concentration measurements on several radionuclides. This should help monitor the French and neighbouring countries nuclear power plants set. It would help evaluate the impact of a radiological incident occurring at one of these nuclear facilities. This paper is devoted to the spatial design of such a network. Here, any potential network is judged on its ability to extrapolate activity concentrations measured on the network stations over the whole domain. The performance of a network is quantitatively assessed through a cost function that measures the discrepancy between the extrapolation and the true concentration fields. These true fields are obtained through the computation of a database of dispersion accidents over one year of meteorology and originating from 20 French nuclear sites. A close to optimal network is then looked for using a simulated annealing optimisation. The results emphasise the importance of the cost function in the design of a network aimed at monitoring an accidental dispersion. Several choices of norm used in the cost function are studied and give way to different designs. The influence of the number of stations is discussed. A comparison with a purely geometric approach which does not involve simulations with a chemistry-transport model is performed.

  8. Numerical analysis of accidental hydrogen releases from high pressure storage at low temperatures

    Markert, Frank; Melideo, Daniele; Baraldi, Daniele

    2014-01-01

    . The vessel dynamics are modeled using a simplified engineering and a CFD model to evaluate the performance of various EOS to predict vessel pressures, temperatures mass flow rates and jet flame lengths. It is shown that the chosen EOS and the chosen specific heat capacity correlation are important to model......Evaluations of the performance of simplified engineering and CFD models are important to improve risk assessment tools e.g. to predict accurately releases from various types of hydrogen storages. These tools have to predict releases from a wide range of storage pressures (up to 80 MPa......) and temperatures (down to 20 K), e.g. cryogenic compressed gas storage covers pressures up to 35 MPa and temperatures between 33 K and 338 K. Accurate calculations of high pressure releases require real gas EOS. This paper compares a number of EOS to predict hydrogen properties typical in different storage types...

  9. Modeling the wind-fields of accidental releases by mesoscale forecasting

    Albritton, J.R.; Lee, R.L.; Mobley, R.L.; Pace, J.C. [Lawrence Livermore National Lab., CA (United States); Hodur, R.A.; Lion, C.S. [Navel Research Lab, Monterey, CA (United States)

    1997-07-01

    Modeling atmospheric releases even during fair weather can present a sever challenge to diagnostic, observed-data-driven, models. Such schemes are often handicapped by sparse input data from meteorological surface stations and soundings. Forecasting by persistence is only acceptable for a few hours and cannot predict important changes in the diurnal cycle or from synoptic evolution. Many accident scenarios are data-sparse in space and/or time. Here we describe the potential value of limited-area, mesoscale, forecast models for real-time emergency response. Simulated wind-fields will be passed to ARAC`s operational models to produce improved forecasts of dispersion following accidents.

  10. Study of applying the Atmospheric Release Advisory Capability to nuclear power plants. [Use of ARAC to forecast hazards of accidental release of radionuclides to the atmosphere

    Orphan, R.C.

    1978-06-01

    Each utility licensee for a nuclear power reactor is required to minimize the adverse effects from an accidental radionuclide release into the atmosphere. In the past the ability to forecast quantitatively the extent of the hazard from such a release has been limited. Now powerful atmospheric modeling techniques are available to assist nuclear reactor site officials with greatly improved assessments. Lawrence Livermore Laboratory (LLL) has developed a prototype system called the Atmospheric Release Advisory Capability (ARAC) which is designed to integrate the modeling with advanced sensors, data handling techniques, and weather data in order to provide timely, usable advisories to the site officials. The purpose of this project is to examine the ways and means of adapting ARAC for application to many nuclear power reactors widely dispersed across the nation. The project will emphasize the management aspects, including government-industry relationships, technology transfer, organizational structure, staffing, implementing procedures, and costs. Benefits and costs for several alternative systems will be compared. The results will be reviewed and evaluated by the management and staff of the ARAC project at LLL and also by selected staff members of the sponsoring government agency.

  11. Calculation of Doses Due to Accidentally Released Plutonium From An LMFBR

    Fish, B.R.

    2001-08-07

    Experimental data and analytical models that should be considered in assessing the transport properties of plutonium aerosols following a hypothetical reactor accident have been examined. Behaviors of released airborne materials within the reactor containment systems, as well as in the atmosphere near the reactor site boundaries, have been semiquantitatively predicted from experimental data and analytical models. The fundamental chemistry of plutonium as it may be applied in biological systems has been used to prepare models related to the intake and metabolism of plutonium dioxide, the fuel material of interest. Attempts have been made to calculate the possible doses from plutonium aerosols for a typical analyzed release in order to evaluate the magnitude of the internal exposure hazards that might exist in the vicinity of the reactor after a hypothetical LMFBR (Liquid-Metal Fast Breeder Reactor) accident. Intake of plutonium (using data for {sup 239}Pu as an example) and its distribution in the body were treated parametrically without regard to the details of transport pathways in the environment. To the extent possible, dose-response data and models have been reviewed, and an assessment of their adequacy has been made so that recommended or preferred practices could be developed.

  12. Prevention and management of accidental foreign body ingestion and aspiration in orthodontic practice

    Umesan UK; Chua KL; Balakrishnan P

    2012-01-01

    Uday Kumar Umesan,1 Kui Lay Chua,1 Priya Balakrishnan21National Dental Centre, 2Kg Kiarong, Bandar Seri Begawan, Brunei DarussalamAbstract: Among the myriad emergencies that could arise in the dental clinical setting there are a few that occur occasionally despite being entirely preventable. Ingestion or aspiration of dental materials, appliances, or instruments comprises this category. Regardless of incidence, foreign body ingestion or aspiration episodes are recognized as potential complica...

  13. Prevention and management of accidental foreign body ingestion and aspiration in orthodontic practice.

    Umesan, Uday Kumar; Chua, Kui Lay; Balakrishnan, Priya

    2012-01-01

    Among the myriad emergencies that could arise in the dental clinical setting there are a few that occur occasionally despite being entirely preventable. Ingestion or aspiration of dental materials, appliances, or instruments comprises this category. Regardless of incidence, foreign body ingestion or aspiration episodes are recognized as potential complications in the specialty of orthodontics. Despite their infrequent occurrence, the morbidity from a single incident and the amount of specialty medical care that may be needed to manage such incidents is too high to ignore. There is also the associated risk of malpractice litigation given the fact that these incidents are preventable. At present, no clear guidelines exist regarding prevention of this emergency in practice. This article attempts to review relevant literature and aims to formulate certain recommendations based on best available evidence to minimize the incidence of such events, while also suggesting guidelines toward making their management more effective. A flow chart outlining management options and strategies to aid the clinician in the event of such an emergency is also presented.

  14. Prevention and management of accidental foreign body ingestion and aspiration in orthodontic practice

    Umesan UK

    2012-05-01

    Full Text Available Uday Kumar Umesan,1 Kui Lay Chua,1 Priya Balakrishnan21National Dental Centre, 2Kg Kiarong, Bandar Seri Begawan, Brunei DarussalamAbstract: Among the myriad emergencies that could arise in the dental clinical setting there are a few that occur occasionally despite being entirely preventable. Ingestion or aspiration of dental materials, appliances, or instruments comprises this category. Regardless of incidence, foreign body ingestion or aspiration episodes are recognized as potential complications in the specialty of orthodontics. Despite their infrequent occurrence, the morbidity from a single incident and the amount of specialty medical care that may be needed to manage such incidents is too high to ignore. There is also the associated risk of malpractice litigation given the fact that these incidents are preventable. At present, no clear guidelines exist regarding prevention of this emergency in practice. This article attempts to review relevant literature and aims to formulate certain recommendations based on best available evidence to minimize the incidence of such events, while also suggesting guidelines toward making their management more effective. A flow chart outlining management options and strategies to aid the clinician in the event of such an emergency is also presented.Keywords: foreign bodies, ingestion, orthodontics, respiratory aspiration, orthodontic appliances

  15. Accidental hypothermia

    Ivo Casagranda

    2006-02-01

    Full Text Available Hypothermia is defined as an unintentional decrease of core body temperature below 35 °C. In this article we discuss pathophysiology, clinical aspects and treatment of hypothermic patients. The most important treatment of hypothermia is the identification of the most appropriate method of rewarming. We report a case of cardiac arrest secondary to severe accidental hypothermia, that occured in a young man, do to prolonged exposure to low temperature in river water, successfully treated with extracorporeal blood warming.

  16. MODELS SELECTED FOR CALCULATION OF DOSES, HEALTH EFFECTS AND ECONOMIC COSTS DUE TO ACCIDENTAL RADIONUCLIDE RELEASES FROM NUCLEAR POWER PLANTS

    Strenge, D L; Baker, D A; Droppo, J G; McPherson, R B; Napier, B A; Nieves, L A; Soldat, J K

    1980-05-01

    Models are described for use in site-specific environmental consequence analysis of nuclear reactor accidents of Classes 3 through 9. The models presented relate radioactivity released to resulting doses, health effects, and costs of remedial actions. Specific models are presented for the major exposure pathways of airborne releases, waterborne releases and direct irradiation from activity within the facility buildings, such as the containment. Time-dependent atmospheric dispersion parameters, crop production parameters and other variable parameters are used in the models. The environmental effects are analyzed for several accident start times during the year.

  17. Risk assessment, risk management and risk-based monitoring following a reported accidental release of poliovirus in Belgium, September to November 2014.

    Duizer, Erwin; Rutjes, Saskia; de Roda Husman, Ana Maria; Schijven, Jack

    2016-01-01

    On 6 September 2014, the accidental release of 10(13) infectious wild poliovirus type 3 (WPV3) particles by a vaccine production plant in Belgium was reported. WPV3 was released into the sewage system and discharged directly to a wastewater treatment plant (WWTP) and subsequently into rivers that flowed to the Western Scheldt and the North Sea. No poliovirus was detected in samples from the WWTP, surface waters, mussels or sewage from the Netherlands. Quantitative microbial risk assessment (QMRA) showed that the infection risks resulting from swimming in Belgium waters were above 50% for several days and that the infection risk by consuming shellfish harvested in the eastern part of the Western Scheldt warranted a shellfish cooking advice. We conclude that the reported release of WPV3 has neither resulted in detectable levels of poliovirus in any of the samples nor in poliovirus circulation in the Netherlands. This QMRA showed that relevant data on water flows were not readily available and that prior assumptions on dilution factors were overestimated. A QMRA should have been performed by all vaccine production facilities before starting up large-scale culture of WPV to be able to implement effective interventions when an accident happens.

  18. Behavior of accidentally released radiocesium in soil-water environment: Looking at Fukushima from a Chernobyl perspective.

    Konoplev, A; Golosov, V; Laptev, G; Nanba, K; Onda, Y; Takase, T; Wakiyama, Y; Yoshimura, K

    2016-01-01

    Quantitative characteristics of dissolved and particulate radiocesium wash-off from contaminated watersheds after the FDNPP accident are calculated based on published monitoring data. Comparative analysis is provided for radiocesium wash-off parameters and distribution coefficients, Kd, between suspended matter and water in rivers and surface runoff on Fukushima and Chernobyl contaminated areas for the first years after the accidents. It was found that radiocesium distribution coefficient in Fukushima rivers is essentially higher (1-2 orders of magnitude) than corresponding values for rivers and surface runoff within the Chernobyl zone. This can be associated with two factors: first, the high fraction of clays in the predominant soils and sediments of the Fukushima area and accordingly a higher value of the radiocesium Interception Potential, RIP, in general, and secondly the presence of water insoluble glassy particles containing radiocesium in the accidental fallout at Fukushima. It was found also that normalized dissolved wash-off coefficients for Fukushima catchments are 1-2 orders of magnitude lower than corresponding values for the Chernobyl zone. Normalized particulate wash-off coefficients are comparable for Fukushima and Chernobyl. Results of the investigation of radiocesium's ((134)Cs and (137)Cs) vertical distribution in soils of the close-in area of the Fukushima Dai-ichi NPP - Okuma town and floodplain of the Niida river are presented. The radiocesium migration in undisturbed forest and grassland soils at Fukushima contaminated area has been shown to be faster as compared to the Chernobyl 30-km zone during the first three years after the accidents. This may be associated with higher annual precipitation (by about 2.5 times) in Fukushima as compared to the Chernobyl zone, as well as the differences in the soil characteristics and temperature regime throughout a year. Investigation and analysis of Fukushima's radiocesium distribution in soils of Niida

  19. Modelling of the tritium dispersion from postulated accidental release of nuclear power plants; Modelagem da dispersao de tritio a partir de liberacoes acidentais postuladas de centrais nucleares

    Soares, Abner Duarte; Simoes Filho, Francisco Fernando Lamego; Cunha, Tatiana Santos da [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Aguiar, Andre Silva de; Lapa, Celso Marcelo Franklin, E-mail: asoares@cnen.gov.b, E-mail: flamego@ien.gov.b, E-mail: lapa@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    This study has the aim to assess the impact of accidental release of tritium postulate from a nuclear power reactor through environmental modeling of aquatic resources. In order to do that it was used computational models to simulation of tritium dispersion caused by an accident in a Candu reactor located in the ongoing Angra 3 site. The Candu reactor is one that uses heavy water (D{sub 2}O) as moderator and coolant of the core. It was postulated, then, the LOCA accident (without fusion), where was lost 66 m3 of soda almost instantaneously. This inventory contained 35 P Bq and was released a load of 9.7 TBq/s in liquid form near the Itaorna beach, Angra dos Reis - RJ. The models mentioned above were applied in two scenarios (plant stopped or operating) and showed a tritium plume with specific activities larger than the reference level for seawater (1.1 MBq/m{sup 3}) during the first 14 days after the accident. (author)

  20. Accidental Innovation

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  1. Modelling of tritium dispersion from postulated accidental release of nuclear power plants; Modelagem da dispersao de tritio a partir de liberacoes acidentais postuladas de centrais nucleares

    Soares, Abner Duarte

    2010-07-01

    This study has the aim to assess the impact of accidental release of tritium postulate from a nuclear power reactor through environmental modeling of aquatic resources. In order to do that it was used computational models of hydrodynamics and transport for the simulation of tritium dispersion caused by an accident in a CANDU reactor located in the ongoing Angra 3 site. This exercise was accomplished with the aid of a code system (SisBAHIA) developed in the Rio de Janeiro Federal University (COPPE/UFRJ). The CANDU reactor is one that uses heavy water (D{sub 2}O) as moderator and coolant of the core. It was postulated, then, the LOCA (Loss of Coolant Accident) accident in the emergency cooling system of the nucleus (without fusion), where was lost 66 m{sup 3} of soda almost instantaneously. This inventory contained 35 PBq and was released a load of 9.7 TBq/s in liquid form near the Itaorna beach, Angra dos Reis - RJ. The models mentioned above were applied in two scenarios (plant stopped and operating) and showed a tritium plume with specific activities larger than the reference level for seawater (1.1 MBq/m{sup 3} ) during the first 14 days after the accident. The main difference between the scenario without and with seawater recirculation (pumping and discharge) is based on the enhancement of dilution of the highest concentrations in the last one. This dilution enhancement resulting in decreasing concentrations was observed only during the first two weeks, when they ranged from 1x10{sup 9} to 5x10{sup 5} Bq/m{sup 3} close to the Itaorna beach spreading just to Sandri Island. After 180 days, the plume could not be detected anymore in the bay, because their activities would be lower than the minimum detectable value (< 11 kBq/m{sup 3}). (author)

  2. Invaders in hot water: a simple decontamination method to prevent the accidental spread of aquatic invasive non-native species.

    Anderson, Lucy G; Dunn, Alison M; Rosewarne, Paula J; Stebbing, Paul D

    Watersports equipment can act as a vector for the introduction and spread of invasive non native species (INNS) in freshwater environments. To support advice given to recreational water users under the UK Government's Check Clean Dry biosecurity campaign and ensure its effectiveness at killing a range of aquatic INNS, we conducted a survival experiment on seven INNS which pose a high risk to UK freshwaters. The efficacy of exposure to hot water (45 °C, 15 min) was tested as a method by which waters users could 'clean' their equipment and was compared to drying and a control group (no treatment). Hot water had caused 99 % mortality across all species 1 h after treatment and was more effective than drying at all time points (1 h: χ(2) = 117.24, p water or drying, 6/7 of these species survived for 16 days, highlighting the importance of good biosecurity practice to reduce the risk of accidental spread. In an additional experiment the minimum lethal temperature and exposure time in hot water to cause 100 % mortality in American signal crayfish (Pacifastacus leniusculus), was determined to be 5 min at 40 °C. Hot water provides a simple, rapid and effective method to clean equipment. We recommend that it is advocated in future biosecurity awareness campaigns.

  3. Accidentes laborales viales

    Corzo Suárez, Susana

    2012-01-01

    El objetivo principal de este proyecto es dar a conocer la problemática de la aplicación del de la ley 31/1995, de 8 de noviembre, de Prevención de Riesgos Laborales, en la evaluación y prevención de los riesgos de los accidentes laborales viales. Para poder llegar a este objetivo se han utilizado diversas vías de estudio: Intentar aclarar qué son accidentes de tráfico y qué son accidentes laborales viales; Cuáles son los diferentes tipos de accidentes laborales viales y sus principales ca...

  4. Modifying sorbents in controlled release formulations to prevent herbicides pollution

    Cespedes, F.F.; Sanchez, M.V.; Garcia, S.P.; Perez, M.F. [University of Almeria, Almeria (Spain). Dept. of Inorganic Chemistry

    2007-10-15

    The herbicides chloridazon and metribuzin, identified as groundwater pollutants, were incorporated in alginate-based granules to obtain controlled release properties. In this research the effect of incorporation of sorbents such as bentonite, anthracite and activated carbon in alginate basic formulation were not only studied on encapsulation efficiency but also on the release rate of herbicides which was studied using water release kinetic tests. In addition, sorption studies of herbicides with bentonite, anthracite and activated carbon were made. The kinetic experiments of chloridazon and metribuzin release in water have shown that the release rate is higher in metribuzin systems than in those prepared with chloridazon, which has lower water solubility. Besides, it can be deduced that the use of sorbents reduces the release rate of the chloridazon and metribuzin in comparison to the technical product and to the alginate formulation without sorbents. The highest decrease in release rate corresponds to the formulations prepared with activated carbon as a sorbent. The water uptake, permeability, and time taken for 50% of the active ingredient to be released into water, were calculated to compare the formulations. On the basis of a parameter of an empirical equation used to fit the herbicide release data, the release of chloridazon and metribuzin from the various formulations into water is controlled by a diffusion mechanism.

  5. Modifying sorbents in controlled release formulations to prevent herbicides pollution.

    Flores Céspedes, F; Villafranca Sánchez, M; Pérez García, S; Fernández Pérez, M

    2007-10-01

    The herbicides chloridazon and metribuzin, identified as groundwater pollutants, were incorporated in alginate-based granules to obtain controlled release properties. In this research the effect of incorporation of sorbents such as bentonite, anthracite and activated carbon in alginate basic formulation were not only studied on encapsulation efficiency but also on the release rate of herbicides which was studied using water release kinetic tests. In addition, sorption studies of herbicides with bentonite, anthracite and activated carbon were made. The kinetic experiments of chloridazon and metribuzin release in water have shown that the release rate is higher in metribuzin systems than in those prepared with chloridazon, which has lower water solubility. Besides, it can be deduced that the use of sorbents reduces the release rate of the chloridazon and metribuzin in comparison to the technical product and to the alginate formulation without sorbents. The highest decrease in release rate corresponds to the formulations prepared with activated carbon as a sorbent. The water uptake, permeability, and time taken for 50% of the active ingredient to be released into water, T(50), were calculated to compare the formulations. On the basis of a parameter of an empirical equation used to fit the herbicide release data, the release of chloridazon and metribuzin from the various formulations into water is controlled by a diffusion mechanism. Sorption capacity of the sorbents for chloridazon and metribuzin, ranging from 0.53mgkg(-1) for the metribuzin sorption on bentonite to 2.03x10(5)mgkg(-1) for the sorption of chloridazon on the activated carbon, was the most important factor modulating the herbicide release.

  6. A multiple lines of evidence approach for the ecological risk assessment of an accidental bitumen release from a steam assisted gravity drainage (SAGD) well in the Athabasca oil sands region.

    Berger, Robert G; Aslund, Melissa Whitfield; Sanders, Greg; Charlebois, Michael; Knopper, Loren D; Bresee, Karl E

    2016-01-15

    To assess the ecological impacts of two independent accidental bitumen releases from two steam assisted gravity drainage (SAGD) wells in the Athabasca oil sands region, a multiple lines of evidence (LOE) approach was developed. Following the release in 2010, action was taken to minimize environmental impact, including the selective removal of the most highly impacted vegetation and the use of oil socks to minimize possible runoff. An ecological risk assessment (ERA) was then conducted based on reported concentrations of bitumen related contaminants in soil, vegetation, and water. Results of biological assessments conducted at the site were also included in the risk characterization. Overall, the conclusion of the ERA was that the likelihood of long-term adverse health effects to ecological receptors in the area was negligible. To provide evidence for this conclusion, a small mammal sampling plan targeting Southern red-back voles (Myodes gapperi) was carried out at two sites and two relevant reference areas. Voles were readily collected at all locations and no statistically significant differences in morphometric measurements (i.e., body mass, length, foot length, and adjusted liver weight) were found between animals collected from impact zones of varying levels of coverage. Additionally, no trends corresponding with bitumen coverage were observed with respect to metal body burden in voles for metals that were previously identified in the source bitumen. Hepatic ethoxyresorufin-O-deethylase (EROD) activity was statistically significantly elevated in voles collected from the high impact zones of sites compared to those collected from the reference areas, a finding that is indicative of continued exposure to contaminants. However, this increase in EROD was not correlated with any observable adverse population-wide biological outcomes. Therefore the biological sampling program supported the conclusion of the initial ERA and supported the hypothesis of no significant

  7. Actividades intersectoriales en la prevención de accidentes de tráfico Intersectorial activities for traffic accident prevention

    R. Peiró

    2003-07-01

    Full Text Available Se describen las líneas de trabajo priorizadas y algunos resultados obtenidos en la implantación del programa de prevención y reducción de lesiones por accidentes de tráfico en un área de salud. A partir de 1999 el Centro de Salud Pública priorizó la identificación y búsqueda de aliados en otros sectores (Asociación de policías locales y educación, la construcción de la capacidad de trabajo conjunta y la formación de un grupo intersectorial. Se llevaron a cabo actividades docentes y jornadas. Se formó una red de personas en 17 de un total de 39 ayuntamientos que participan con actividades en el grupo intersectorial. Un total de 10 de estos ayuntamientos participaron con actividades educativas y siete, además, exigieron al cumplimiento de la legislación. El grupo intersectorial potenció la visibilidad de sus actividades a través de los medios de comunicación local. Estas actividades no están dirigidas a reducir las lesiones por tráfico, sino a crear un marco de trabajo para la movilización de los sectores implicados. Se pretende potenciar más el compromiso entre los niveles políticos, técnicos y civiles incidiendo en valores sociales de respeto para una vida más saludable.We describe priority issues and some of the results obtained from the implementation of the «Prevention and Reduction of Traffic Accident Injuries» program in a health area. Since 1999 the public health center has made a priority of identifying and recruiting partners from other sectors (the local police association and the local education authority, increasing its capacity for working together, and setting up an intersectorial working group. Teaching activities and meetings were held. A network of people was created from 17 of a total of 39 town halls that participate in activities supported by the intersectorial group. Ten are involved in educational activities and a further seven focus on ensuring compliance with the law. The intersectorial group

  8. Accidental Bowel Leakage

    ... I do to help treat accidental bowel leakage? Kegel exercises strengthen the muscles that surround the openings ... bowels that may cause cramping, diarrhea, or constipation. Kegel Exercises: Pelvic muscle exercises that assist in bladder ...

  9. Safety barriers on oil and gas platforms. Means to prevent hydrocarbon releases

    Sklet, Snorre

    2005-12-15

    The main objective of the PhD project has been to develop concepts and methods that can be used to define, illustrate, analyse, and improve safety barriers in the operational phase of offshore oil and gas production platforms. The main contributions of this thesis are; Clarification of the term safety barrier with respect to definitions, classification, and relevant attributes for analysis of barrier performance Development and discussion of a representative set of hydrocarbon release scenarios Development and testing of a new method, BORA-Release, for qualitative and quantitative risk analysis of hydrocarbon releases Safety barriers are defined as physical and/or non-physical means planned to prevent, control, or mitigate undesired events or accidents. The means may range from a single technical unit or human actions, to a complex socio-technical system. It is useful to distinguish between barrier functions and barrier systems. Barrier functions describe the purpose of safety barriers or what the safety barriers shall do in order to prevent, control, or mitigate undesired events or accidents. Barrier systems describe how a barrier function is realized or executed. If the barrier system is functioning, the barrier function is performed. If a barrier function is performed successfully, it should have a direct and significant effect on the occurrence and/or consequences of an undesired event or accident. It is recommended to address the following attributes to characterize the performance of safety barriers; a) functionality/effectiveness, b) reliability/ availability, c) response time, d) robustness, and e) triggering event or condition. For some types of barriers, not all the attributes are relevant or necessary in order to describe the barrier performance. The presented hydrocarbon release scenarios include initiating events, barrier functions introduced to prevent hydrocarbon releases, and barrier systems realizing the barrier functions. Both technical and human

  10. Safety barriers on oil and gas platforms. Means to prevent hydrocarbon releases

    Sklet, Snorre

    2005-12-15

    The main objective of the PhD project has been to develop concepts and methods that can be used to define, illustrate, analyse, and improve safety barriers in the operational phase of offshore oil and gas production platforms. The main contributions of this thesis are; Clarification of the term safety barrier with respect to definitions, classification, and relevant attributes for analysis of barrier performance Development and discussion of a representative set of hydrocarbon release scenarios Development and testing of a new method, BORA-Release, for qualitative and quantitative risk analysis of hydrocarbon releases Safety barriers are defined as physical and/or non-physical means planned to prevent, control, or mitigate undesired events or accidents. The means may range from a single technical unit or human actions, to a complex socio-technical system. It is useful to distinguish between barrier functions and barrier systems. Barrier functions describe the purpose of safety barriers or what the safety barriers shall do in order to prevent, control, or mitigate undesired events or accidents. Barrier systems describe how a barrier function is realized or executed. If the barrier system is functioning, the barrier function is performed. If a barrier function is performed successfully, it should have a direct and significant effect on the occurrence and/or consequences of an undesired event or accident. It is recommended to address the following attributes to characterize the performance of safety barriers; a) functionality/effectiveness, b) reliability/ availability, c) response time, d) robustness, and e) triggering event or condition. For some types of barriers, not all the attributes are relevant or necessary in order to describe the barrier performance. The presented hydrocarbon release scenarios include initiating events, barrier functions introduced to prevent hydrocarbon releases, and barrier systems realizing the barrier functions. Both technical and human

  11. A time-release technique for corrosion prevention

    Dry, C.M.; Corsaw, M.J.T. [Univ. of Illinois, Champaign, IL (United States). School of Architecture

    1998-08-01

    Researchers at the University of Illinois have developed an anti-corrosion system that is activated automatically where and when it is needed. Porous fibers are filled with calcium nitrite and coated with a salt-sensitive substance to control the response. The release of the corrosion inhibitor chemical is at the portion of the reinforcing bar in danger of corrosion when conditions would allow corrosion to initiate. In a series of tests with concrete samples containing either no protection or the conventional freely mixed calcium nitrite, this system performed well in that it delayed the onset of corrosion by at least three weeks in the laboratory specimens and reduced the amount of total corrosion by more than half.

  12. Radiative accidental matter

    Sierra, D Aristizabal; Wegman, D

    2016-01-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that $\\mu\\to e \\gamma$ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below $10^6\\,$ GeV, a value (natur...

  13. The Impact of Pollution Prevention on Toxic Environmental Releases from U.S. Manufacturing Facilities.

    Ranson, Matthew; Cox, Brendan; Keenan, Cheryl; Teitelbaum, Daniel

    2015-11-03

    Between 1991 and 2012, the facilities that reported to the U.S. Environmental Protection Agency's Toxic Release Inventory (TRI) Program conducted 370,000 source reduction projects. We use this data set to conduct the first quasi-experimental retrospective evaluation of how implementing a source reduction (pollution prevention) project affects the quantity of toxic chemicals released to the environment by an average industrial facility. We use a differences-in-differences methodology, which measures how implementing a source reduction project affects a facility's releases of targeted chemicals, relative to releases of (a) other untargeted chemicals from the same facility, or (b) the same chemical from other facilities in the same industry. We find that the average source reduction project causes a 9-16% decrease in releases of targeted chemicals in the year of implementation. Source reduction techniques vary in effectiveness: for example, raw material modification causes a large decrease in releases, while inventory control has no detectable effect. Our analysis suggests that in aggregate, the source reduction projects carried out in the U.S. since 1991 have prevented between 5 and 14 billion pounds of toxic releases.

  14. Gibberellin-enhanced elongation of inverted Pharbitis nil shoot prevents the release of apical dominance

    Prasad, T. K.; Cline, M. G.

    1987-01-01

    Ethylene evolution resulting from the gravity stress of shoot inversion appears to induce the release of apical dominance in Pharbitis nil (L.) by inhibiting elongation of the inverted shoot. It has been previously demonstrated that this shoot inversion release of apical dominance can be prevented by promoting elongation in the inverted shoot via interference with ethylene synthesis or action. In the present study it was shown that apical dominance release can also be prevented by promoting elongation of the inverted shoot via treatment with gibberellic acid (GA3). A synergistic effect was observed when AgNO3, the ethylene action inhibitor, was applied with GA3. Both GA3 and AgNO3 increased ethylene production in the inverted shoot. These results are consistent with the view that it is ethylene-induced inhibition of elongation and not any direct effect of ethylene per se which is responsible for the outgrowth of the highest lateral bud.

  15. 防范突发性海上石油污染的国际法律制度研究%International Legal Regime of Preventing Accidental Oil Pollution at Sea

    张相君

    2011-01-01

    Accidental oil pollution at sea and inter alia grave accidental pollution near seashore may cause immense damages.Since the end of World War I,the international community has begun to realize problems caused by oil pollution at sea and attempted to resolve them.It was when the Second World War ended,efforts by the international community finally turned out to be fruitful,which was due to grave oil pollution accidents in a short time.International legal regime was finally framed out and made noticeable success after several decades of practice.Efforts and successes by the international community on preventing accidental oil pollution will be of inspirations for China,which is now rapidly developing its marine economies.%海上突发性石油污染事故,尤其是发生在近岸海域的大型溢油事故对海洋环境造成了巨大损害。自一战之后,国际社会即开始意识到海上石油污染所造成的种种问题并试图在国际法上予以解决。至二战之后,遭受到巨大海上石油污染事故的冲击之后,国际社会的努力才真正开花结果,相应的国际法律规范逐渐丰富完善起来,并经过数十年的实践取得了明显成果。国际社会在防范突发性海上石油污染事故方面的努力,对于正快速发展海洋经济的中国如何防范此类突发事故具有很好的借鉴和启示作用。

  16. Flavour from accidental symmetries

    Ferretti, Luca [SISSA/ISAS and INFN, I-34013 Trieste (Italy); King, Stephen F. [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Romanino, Andrea [SISSA/ISAS and INFN, I-34013 Trieste (Italy)

    2006-11-15

    We consider a new approach to fermion masses and mixings in which no special 'horizontal' dynamics is invoked to account for the hierarchical pattern of charged fermion masses and for the peculiar features of neutrino masses. The hierarchy follows from the vertical, family-independent structure of the model, in particular from the breaking pattern of the Pati-Salam group. The lightness of the first two fermion families can be related to two family symmetries emerging in this context as accidental symmetries.

  17. Environmental Release Prevention and Control Plan (ERP and CP) annual review and update for 1993

    Jannik, G.T. [comp.; Mamatey, A.; Arnett, M.

    1993-10-05

    In the Environmental Release Prevention and Control Plan (ERP and CP), WSRC made a commitment to conduct the following follow-up activities and actions: (1) Complete the action items developed in response to the findings and recommendation of the Environmental Release Prevention Taskteam (WSRC-RP-92-356). (2) Complete all batch and continuous release procedure revisions to incorporate the attributes that WSRC senior management required of each procedure. (3) DOE-SR Assistance Managers and WSRC counterparts to reach consensus and closure on the identified engineered solutions documented in the ERP and CP, develop and drive implementation of facility changes per the agreements. (4) Continue to analyze releases and monitor performance in accordance with the ERP and CP, and utilize the ALARA Release Guides Committee to drive improvements. (5) Conduct annual re-evaluations of the cost benefit analyses of the identified engineered solutions, and identify new options and alternatives for each outfall in response to site mission and facility changes. This report documents the efforts that have been completed over the past year in response to these commitments.

  18. HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane.

    2006-05-01

    Full Text Available The human immunodeficiency virus (HIV type-1 viral protein U (Vpu protein enhances the release of diverse retroviruses from human, but not monkey, cells and is thought to do so by ablating a dominant restriction to particle release. Here, we determined how Vpu expression affects the subcellular distribution of HIV-1 and murine leukemia virus (MLV Gag proteins in human cells where Vpu is, or is not, required for efficient particle release. In HeLa cells, where Vpu enhances HIV-1 and MLV release approximately 10-fold, concentrations of HIV-1 Gag and MLV Gag fused to cyan fluorescent protein (CFP were initially detected at the plasma membrane, but then accumulated over time in early and late endosomes. Endosomal accumulation of Gag-CFP was prevented by Vpu expression and, importantly, inhibition of plasma membrane to early endosome transport by dominant negative mutants of Rab5a, dynamin, and EPS-15. Additionally, accumulation of both HIV and MLV Gag in endosomes required a functional late-budding domain. In human HOS cells, where HIV-1 and MLV release was efficient even in the absence of Vpu, Gag proteins were localized predominantly at the plasma membrane, irrespective of Vpu expression or manipulation of endocytic transport. While these data indicated that Vpu inhibits nascent virion endocytosis, Vpu did not affect transferrin endocytosis. Moreover, inhibition of endocytosis did not restore Vpu-defective HIV-1 release in HeLa cells, but instead resulted in accumulation of mature virions that could be released from the cell surface by protease treatment. Thus, these findings suggest that a specific activity that is present in HeLa cells, but not in HOS cells, and is counteracted by Vpu, traps assembled retrovirus particles at the cell surface. This entrapment leads to subsequent endocytosis by a Rab5a- and clathrin-dependent mechanism and intracellular sequestration of virions in endosomes.

  19. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats.

    Tzu-Yu Lin

    Full Text Available An excessive release of glutamate is considered to be a molecular mechanism associated with several neurological diseases that causes neuronal damage. Therefore, searching for compounds that reduce glutamate neurotoxicity is necessary. In this study, the possibility that the natural flavone acacetin derived from the traditional Chinese medicine Clerodendrum inerme (L. Gaertn is a neuroprotective agent was investigated. The effect of acacetin on endogenous glutamate release in rat hippocampal nerve terminals (synaptosomes was also investigated. The results indicated that acacetin inhibited depolarization-evoked glutamate release and cytosolic free Ca(2+ concentration ([Ca(2+]C in the hippocampal nerve terminals. However, acacetin did not alter synaptosomal membrane potential. Furthermore, the inhibitory effect of acacetin on evoked glutamate release was prevented by the Cav2.2 (N-type and Cav2.1 (P/Q-type channel blocker known as ω-conotoxin MVIIC. In a kainic acid (KA rat model, an animal model used for excitotoxic neurodegeneration experiments, acacetin (10 or 50 mg/kg was administrated intraperitoneally to the rats 30 min before the KA (15 mg/kg intraperitoneal injection, and subsequently induced the attenuation of KA-induced neuronal cell death and microglia activation in the CA3 region of the hippocampus. The present study demonstrates that the natural compound, acacetin, inhibits glutamate release from hippocampal synaptosomes by attenuating voltage-dependent Ca(2+ entry and effectively prevents KA-induced in vivo excitotoxicity. Collectively, these data suggest that acacetin has the therapeutic potential for treating neurological diseases associated with excitotoxicity.

  20. Guia de cuidados de enfermagem na prevenção da extubação acidental Conductas de enfermería para la prevención de la extubación accidental Guideline for nursing care in the prevention of accidental extubation

    Théia Maria Forny Wanderley Castellões

    2007-02-01

    Full Text Available Artigo que relata a experiência do emprego de um guia preventivo da extubação acidental que ocorre associada ao cuidado de enfermagem para os quatro momentos de maior incidência e que são: banho no leito, transporte, troca de fixação e mudança de decúbito. O conteúdo do guia está pautado nas recomendações encontradas em levantamento bibliográfico no MedLine e na experiência profissional. O guia vem sendo aplicado desde setembro de 2005. Espera-se que o guia contribua para diminuir cada vez mais a incidência da extubação acidental e por tanto seja uma ferramenta para desenvolver um indicador de qualidade na Unidade de Terapia Intensiva, assim como, seja capaz de oferecer uma assistência que objetive a segurança do paciente.És un artículo que trata del empleo de un guía para orientar los cuidados de enfermería e evitar la extubación que ocurre con más frecuencia en cuatro tiempos: en el baño, la transferencia del enfermo, el cambio de la fixación y los cambios de posición en la cama. Su contenido se apoyo en la experiencia y en levantamiento bibliográfico en el Medline.Se ha venido usando desde septiembre de 2005 y hemos tenido solo dos extubaciones. Creemos que sirva para atender al enfermo con más seguranza así también como un indicador de calidad de enfermería.Article reports the experience of the use of a preventive guideline for the prevention of accidental extubation that occurs associated nursing care for the four moments of bigger incidence that are: bath in the stream bed, transportation, exchange of setting and change of decubitus. The content of the guide is based in the recommendations found in bibliographical survey in the MedLine and in the professional experience. The guideline is being used since September, 2005. This contribution aims at decreasing extubation incidence and to be a tool to develop a quality indicator in Intensive Care Units as well as for offering an assistance that aims patient

  1. Accidental dapsone poisoning in children.

    Nair, P M; Philip, E

    1984-12-01

    Accidental poisoning in children shows a trend towards poisoning with various newer drugs and chemicals used in the household. Sixty-one cases of accidental poisoning in children were seen in Sree Avittam Thirunal Hospital, (S.A.T.H.), Trivandrum, South India during the year 1982, constituting 0.61% of the total pediatric admissions. Dapsone poisoning constituted 9.8% of the total accidental poisonings, emphasising the need for safe storage of drugs out of the reach of young children. Dapsone poisoning with resultant methaemoglobinaemia responded well to intravenous ascorbic acid and other supportive measures.

  2. Novel application method of talcum powder to prevent sticking tendency and modify release of esomeprazole magnesium enteric-coated pellets.

    Liu, Zan; Wang, Weiwei; Chen, Hao; Liu, Jianping; Zhang, Wenli

    2016-01-01

    Actually, reflecting drug release from polymer-coated pellets remains a challenge. In this study, sticking of pellets caused by Eudragit®L30D-55 was observed during the release process, leading to change in drug release. Talcum powder (talc) was used in esomeprazole magnesium pellets to prevent sticking and modify release of pellets. Three methods including talc incorporated in enteric layer, physically mixed and coating resulted pellets were employed to prevent the sticking. The release of pellets was modified by addition talc into subcoat. The dispersion coefficient (Fd) and release profiles were determined in phosphate buffer solution (pH 6.8 and 6.0) and distilled water. It was found that the first manner made Fd increase to about 0.75, but the latter two methods could completely prevent sticking. Also, the second manner was more simple and readily scaled up. In addition, talc in subcoat significantly slowed the drug release in water, but the slowing release effect is less pronounced at pH 6.0 and 6.8. These different effects of talc were attributed to a different release mechanism in three media. The release profiles in water were fitted to Nuttanan model, and the K designated as "diffusive resistance constant" was linearly increased with talc levels in subcoat (R(2)=0.9874).

  3. Ultra Structural Characterisation of Tetherin - a Protein Capable of Preventing Viral Release from the Plasma Membrane

    Ravindra K. Gupta

    2010-04-01

    Full Text Available Tetherin is an antiviral restriction factor made by mammalian cells to protect them from viral infection. It prevents newly formed virus particles from leaving infected cells. Its antiviral mechanism appears to be remarkably uncomplicated. In 2 studies published in PLoS Pathogens electron microscopy is used to support the hypothesis that the tethers that link HIV-1 virions to tetherin expressing cells contain tetherin and are likely to contain tetherin alone. They also show that the HIV-1 encoded tetherin antagonist that is known to cause tetherin degradation, Vpu, serves to reduce the amount of tetherin in the particles thereby allowing their release.

  4. Curing agent for polyepoxides and epoxy resins and composites cured therewith. [preventing carbon fiber release

    Serafini, T. T.; Delvigs, P.; Vannucci, R. D. (Inventor)

    1981-01-01

    A curing for a polyepoxide is described which contains a divalent aryl radical such as phenylene a tetravalent aryl radical such as a tetravalent benzene radical. An epoxide is cured by admixture with the curing agent. The cured epoxy product retains the usual properties of cured epoxides and, in addition, has a higher char residue after burning, on the order of 45% by weight. The higher char residue is of value in preventing release to the atmosphere of carbon fibers from carbon fiber-epoxy resin composites in the event of burning of the composite.

  5. Allegheny County Fatal Accidental Overdoses

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Fatal accidental overdose incidents in Allegheny County, denoting age, gender, race, drugs present, zip code of incident and zip code of residence. Zip code of...

  6. Ovarian hyperstimulation syndrome prevention strategies: use of gonadotropin-releasing hormone antagonists.

    Griesinger, Georg

    2010-11-01

    The most serious complication of ovarian stimulation for in vitro fertilization is severe ovarian hyperstimulation syndrome (OHSS), a rare but potentially life-threatening condition. The present review discusses the place of gonadotropin-releasing hormone antagonists (GnRH-ant) in primary, secondary, and tertiary prevention of OHSS. Sound evidence indicates that the routine use of GnRH-ant instead of GnRH agonists (GnRHa) during ovarian stimulation drastically reduces the relative risk of OHSS. GnRH-ant are therefore useful for primary OHSS prevention, and an increased use of antagonists should help reduce the overall incidence of severe OHSS with its associated risks and complications. In patients on antagonist protocols identified to be at risk of developing severe OHSS, replacing human chorionic gonadotropin with GnRHa as a trigger of final oocyte maturation has been proposed as an effective measure of secondary prevention. A concept of combining GnRHa triggering with cryopreservation of all oocytes or embryos has yielded promising results as far as total avoidance of OHSS is concerned while providing a good chance of pregnancy for the patient in later frozen-thawed embryo transfers. In patients with early onset of OHSS, reinitiation of GnRH-ant in the luteal phase as a measure of tertiary prevention might lead to rapid regression of the syndrome; however only limited data on this new concept are available in the literature.

  7. Use of levonorgestrel-releasing intrauterine system in the prevention and treatment of endometrial hyperplasia.

    Ewies, Ayman A A; Alfhaily, Fadi

    2012-11-01

    Endometrial hyperplasia is a commonly seen gynecological condition that affects women of all age groups. Whereas hysterectomy is the most preferred treatment option for complex endometrial hyperplasia with atypia, there is no consensus regarding the first-line management of women with hyperplasia without cytological atypia. Oral progestogen therapy was used with some success. Nonetheless, it may be plausible to argue that women with endometrial hyperplasia need continuous treatment and high level of compliance to ensure complete regression, which may not be guaranteed with oral therapy. Observational studies suggested that levonorgestrel-releasing intrauterine system (LNG-IUS) has been successfully used to treat endometrial hyperplasia without cytological atypia and selected cases of atypical endometrial hyperplasia. Furthermore, there is strong evidence from randomized controlled trials that LNG-IUS prevents the development of endometrial hyperplasia in exogenous estrogen users; however, its protective role and safety in tamoxifen-treated breast cancer survivors remain uncertain. This article evaluates the current evidence for the use of LNG-IUS, releasing 20 μg of LNG per day, in the prevention and treatment of endometrial hyperplasia.

  8. Prevention of organ rejection in renal and liver transplantation with extended release tacrolimus

    Reschen ME

    2014-09-01

    Full Text Available Michael E Reschen, Christopher A O’Callaghan Henry Wellcome Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom Abstract: Tacrolimus is the key immunosuppressant used to prevent allograft rejection in kidney and liver transplant recipients. Despite the efficacy of tacrolimus and adjunctive immunosuppressants, a substantial number of patients experience episodes of acute rejection and late graft loss. Nonadherence is an etiological factor in both acute rejection and graft loss. In 2007, a prolonged release version of tacrolimus became available that allows once daily administration, thus halving the pill burden compared to the standard twice-daily tacrolimus. An increasing number of studies in de novo transplantation and in treatment conversion have evaluated the pharmacokinetic profile, efficacy, and safety of prolonged-release tacrolimus. We have reviewed the literature on the use of prolonged-release tacrolimus and hope that this will be of value in the design of protocols for transplant immunosuppression.Keywords: immunosuppression, kidney, hepatic, allograft, adherence

  9. Medidas y estrategias para la prevención y control de los accidentes de tránsito: experiencia peruana por niveles de prevención Actions and strategies for the prevention and control of road traffic injuries: peruvian experience by levels of prevention

    Hernán Málaga

    2010-06-01

    Full Text Available El presente artículo busca describir las principales medidas de prevención primaria y secundaria sobre accidentes de tránsito que vienen desarrollándose en Perú, considerando aspectos epidemiológicos propios de la experiencia peruana, como lo reportado en otros países. Se aborda lo a nivel de prevención primaria lo relacionado a la restricción horaria de expendio de bebidas alcohólicas, detección de conductores con alcoholemia positiva y el conductor elegido. En cuanto a prevención secundaria, se presenta los estudios de puntos negros y los barriles de contención de impacto, asimismo, una breve visión de los sistemas de atención pre hospitalaria en el caso de los traumatismos por accidentes de tránsito. Existe la necesidad de una mejor caracterización del problema, para establecer las políticas públicas saludables en lo concerniente a accidentes de tránsito, existe la necesidad de valoraciones basadas en evidencia científica y en estudios de evaluaciones económicas.This article aims to describe the main actions that are being developed in Peru for primary and secondary prevention of road traffic injuries, considering the epidemiological aspects that characterize the Peruvian experience, as reported in other countries. At the primary prevention level, it addresses issues related to the timing restriction of the sales of alcoholic beverages, detection of drivers with positive testing for alcohol in blood and the chosen driver. Regarding secondary prevention, the studies on black spots and the impact containment barrels are presented, also a brief overview of the pre-hospital care systems in the case of road traffic injuries. There is a need for better characterization of the problem, in order to establish healthy public policies regarding traffic accidents, there is a need for evidence-based reviews and studies of economic evaluations.

  10. Ten Tips to Prevent an Accidental Overdose

    ... Devices for Orally Ingested OTC Liquid Drug Products (PDF - 595KB) Drug Interactions: What You Should Know ... & Veterinary Children's Health Cosmetics Dietary Supplements Drugs Food Medical Devices Nutrition Radiation-Emitting Products ...

  11. Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

    Bueno, Giselle Oliveira Vieira

    2007-07-01

    In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that

  12. Role of tacrolimus prolonged release in the prevention of allograft rejection

    Peter Abrams

    2010-08-01

    Full Text Available Peter Abrams, Abhinav Humar, Henkie P TanDepartment of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pennsylvania, USAAbstract: Successful management of the solid-organ transplant recipient begins with prevention of rejection and achieving a balance between insufficient and excessive immunosuppression. Standard tacrolimus therapy for prevention of solid-organ transplant rejection consists of 2 divided doses per day. In an effort to simplify tacrolimus dosing to once daily, a new formulation (tacrolimus prolonged release [PR] was chosen for its combination of a similar extent of bioavailability and a substantially reduced rate of clearance. Several clinical conversion studies have now been completed using PR to clarify its pharmacokinetics, efficacy at prevention of allograft rejection, and safety profiles in solid-organ transplant patients. A cohort of 67 stable kidney transplant recipients was converted from standard tacrolimus to PR in an open-label, multicenter study in the United States and Canada. A second open-label, multicenter study was performed in liver transplant recipients with stable graft function on standard tacrolimus therapy converted to PR. A third conversion study was performed as an open-label study at 5 centers in the United States in stable pediatric liver transplant recipients. As medication noncompliance can significantly contribute to the incidence of graft rejection and graft loss in transplant recipients, a potentially significant advance in the transplant community’s ongoing mission to optimize prevention of rejection occurred with the development of a once-daily tacrolimus PR. The results of these preliminary studies suggest that select solid-organ transplant recipients converted to PR can be safely maintained using the same monitoring and patient care techniques historically used for standard tacrolimus therapy.Keywords: immunosuppression, tacrolimus allograft

  13. Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device.

    Murphy, Diarmaid J; Boyd, Peter; McCoy, Clare F; Kumar, Sandeep; Holt, Jonathon D S; Blanda, Wendy; Brimer, Andrew N; Malcolm, R Karl

    2016-03-28

    Despite a long history of incorporating steroids into silicone elastomers for drug delivery applications, little is presently known about the propensity for irreversible drug binding in these systems. In this study, the ability of the contraceptive progestin levonorgestrel to bind chemically with hydrosilane groups in addition-cure silicone elastomers has been thoroughly investigated. Cure time, cure temperature, levonorgestrel particle size, initial levonorgestrel loading and silicone elastomer type were demonstrated to be key parameters impacting the extent of levonorgestrel binding, each through their influence on the solubility of levonorgestrel in the silicone elastomer. Understanding and overcoming this levonorgestrel binding phenomenon is critical for the ongoing development of a number of drug delivery products, including a multi-purpose technology vaginal ring device offering simultaneous release of levonorgestrel and dapivirine - a lead candidate antiretroviral microbicide - for combination HIV prevention and hormonal contraception.

  14. Applications of human factors engineering to LNG release prevention and control

    Shikiar, R.; Rankin, W.L.; Rideout, T.B.

    1982-06-01

    The results of an investigation of human factors engineering and human reliability applications to LNG release prevention and control are reported. The report includes a discussion of possible human error contributions to previous LNG accidents and incidents, and a discussion of generic HF considerations for peakshaving plants. More specific recommendations for improving HF practices at peakshaving plants are offered based on visits to six facilities. The HF aspects of the recently promulgated DOT regulations are reviewed, and recommendations are made concerning how these regulations can be implemented utilizing standard HF practices. Finally, the integration of HF considerations into overall system safety is illustrated by a presentation of human error probabilities applicable to LNG operations and by an expanded fault tree analysis which explicitly recognizes man-machine interfaces.

  15. Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.

    Lou, Xuelin; Fan, Fan; Messa, Mirko; Raimondi, Andrea; Wu, Yumei; Looger, Loren L; Ferguson, Shawn M; De Camilli, Pietro

    2012-02-21

    Endocytic recycling of synaptic vesicles after exocytosis is critical for nervous system function. At synapses of cultured neurons that lack the two "neuronal" dynamins, dynamin 1 and 3, smaller excitatory postsynaptic currents are observed due to an impairment of the fission reaction of endocytosis that results in an accumulation of arrested clathrin-coated pits and a greatly reduced synaptic vesicle number. Surprisingly, despite a smaller readily releasable vesicle pool and fewer docked vesicles, a strong facilitation, which correlated with lower vesicle release probability, was observed upon action potential stimulation at such synapses. Furthermore, although network activity in mutant cultures was lower, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity was unexpectedly increased, consistent with the previous report of an enhanced state of synapsin 1 phosphorylation at CaMKII-dependent sites in such neurons. These changes were partially reversed by overnight silencing of synaptic activity with tetrodotoxin, a treatment that allows progression of arrested endocytic pits to synaptic vesicles. Facilitation was also counteracted by CaMKII inhibition. These findings reveal a mechanism aimed at preventing synaptic transmission failure due to vesicle depletion when recycling vesicle traffic is backed up by a defect in dynamin-dependent endocytosis and provide new insight into the coupling between endocytosis and exocytosis.

  16. Prevention of invasive fungal infections in immunocompromised patients: the role of delayed-release posaconazole

    Soysal A

    2015-09-01

    Full Text Available Ahmet SoysalDivision of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul, TurkeyAbstract: Posaconazole is a triazole antifungal agent that has broad-spectrum activity against many yeasts and filamentous fungi, including Candida species, Cryptococcus neoformans, Aspergillus species, and Zygomycetes. This drug has been approved for the prevention of invasive fungal infections in patients with neutropenia and for the treatment of invasive fungal infections in hematopoietic stem cell transplant recipients with graft-versus-host disease. Studies on the clinical efficacy, safety, tolerability, and cost-effectiveness of posaconazole therapy were performed using the oral suspension form of the drug. Pharmacokinetic studies have found that the oral suspension form of posaconazole has problemeatic bioavailability: its absorption is affected by concomitant medication and food. This article discusses the pharmacokinetic properties of the newly developed posaconazole delayed-release tablet formulation and reviews the efficacy, safety, and cost-effectiveness of both the oral suspension and the new tablet formulation. In conclusion, the posaconazole tablet formulation has better systemic bioavailability, thereby enabling once-daily administration and better absorption in the presence of concomitant medication and food. However, well-designed clinical studies are needed to evaluate the use of the tablet formulation in real-life settings.Keywords: posaconazole delayed-release tablet, prophylaxis, invasive fungal infections

  17. Fluoride-Releasing Materials to Prevent White Spot Lesions around Orthodontic Brackets: A Systematic Review.

    Nascimento, Patrícia Layane de Menezes Macêdo; Fernandes, Micaelle Tenório Guedes; Figueiredo, Fabricio Eneas Diniz de; Faria-E-Silva, André Luis

    2016-01-01

    The relation between orthodontic fixed appliances use and enamel demineralization is well established. Different preventive approaches have been suggested to this problem, but controversy remains about which is the best. The aim of this study was to perform a systematic review of clinical trials that investigated the effectiveness of materials containing fluorides to lute brackets or cover the bonding interface in order to inhibit the development and progression of white spot lesions. The null hypothesis was that fluoride materials do not affect the incidence of white spot lesions around brackets. A MEDLINE search was conducted for randomized clinical trials evaluating the development of white spot lesions in patients using fixed orthodontic appliances, followed by meta-analysis comparing the results for patients for whom dental materials containing fluorides were used (experimental group) to those for whom these materials were not used (control group). The pooled relative risk of developing white spot lesions for the experimental group was 0.42 (95% confidence interval: 0.25 to 0.72); hence, when fluoride-releasing materials are used, the patient has 58% less risk of white spot lesion development. Regarding white spot lesion extent, the pooled mean difference between the experimental and control groups was not statistically significant (-0.12; 95% confidence interval: -0.29 to 0.04). In conclusion, the results of the present systematic review suggest that fluoride-releasing materials can reduce the risk of white spot lesions around brackets. However, when white spot lesions had already occurred, there is no evidence that fluoride-releasing materials reduce the extent of these lesions.

  18. Accidental injuries in agriculture in the UK.

    Solomon, C

    2002-12-01

    The rate of occupational accidents in British agriculture is higher than in most other industries. The most common fatal accidents are those involving vehicles and machinery, falls from a height and electrocution. A substantial proportion of reported non-fatal injuries in agricultural employees is attributable to manual handling, but among self-employed farmers the contribution is much smaller. Few data are available on longer-term determinants of risk, but accidental deaths are most frequent in July, August and September. The main approaches to preventing agricultural accidents are through engineering improvements, and education and training of the workforce. The introduction of roll-over protection structures for tractors has been an important development in recent decades. Other engineering controls include guards for power take off shafts, guard rails to prevent falls, better handling facilities for animals and closed transfer systems for pesticides. Training on safety is available from several sources, but its effectiveness in reducing accidents is uncertain.

  19. Accidental hypothermia-an update

    Paal, Peter; Gordon, Les; Strapazzon, Giacomo

    2016-01-01

    BACKGROUND: This paper provides an up-to-date review of the management and outcome of accidental hypothermia patients with and without cardiac arrest. METHODS: The authors reviewed the relevant literature in their specialist field. Summaries were merged, discussed and approved to produce this nar...

  20. Accidente de Trabajo y Recargo

    Pérez Alonso, María Antonia

    2015-01-01

    En la actualidad existen diferentes formas de Accidente de Trabajo. En el presente trabajo se da a conocer las distintas formas y la doctrina de los tribunales. Se aborda el recargo de prestaciones de Seguridad Social y el deber del empresario en cumplir la normativa de Seguridad Social

  1. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release.

    Pamenter, Matthew E; Ryu, Julie; Hua, Serena T; Perkins, Guy A; Mendiola, Vincent L; Gu, Xiang Q; Ellisman, Mark H; Haddad, Gabriel G

    2012-01-01

    During stroke, cells in the infarct core exhibit rapid failure of their permeability barriers, which releases ions and inflammatory molecules that are deleterious to nearby tissue (the penumbra). Plasma membrane degradation is key to penumbral spread and is mediated by matrix metalloproteinases (MMPs), which are released via vesicular exocytosis into the extracellular fluid in response to stress. DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid) preserves membrane integrity in neurons challenged with an in vitro ischemic penumbral mimic (ischemic solution: IS) and we asked whether this action was mediated via inhibition of MMP activity. In cultured murine hippocampal neurons challenged with IS, intracellular proMMP-2 and -9 expression increased 4-10 fold and extracellular latent and active MMP isoform expression increased 2-22 fold. MMP-mediated extracellular gelatinolytic activity increased ∼20-50 fold, causing detachment of 32.1±4.5% of cells from the matrix and extensive plasma membrane degradation (>60% of cells took up vital dyes and >60% of plasma membranes were fragmented or blebbed). DIDS abolished cellular detachment and membrane degradation in neurons and the pathology-induced extracellular expression of latent and active MMPs. DIDS similarly inhibited extracellular MMP expression and cellular detachment induced by the pro-apoptotic agent staurosporine or the general proteinase agonist 4-aminophenylmercuric acetate (APMA). Conversely, DIDS-treatment did not impair stress-induced intracellular proMMP production, nor the intracellular cleavage of proMMP-2 to the active form, suggesting DIDS interferes with the vesicular extrusion of MMPs rather than directly inhibiting proteinase expression or activation. In support of this hypothesis, an antagonist of the V-type vesicular ATPase also inhibited extracellular MMP expression to a similar degree as DIDS. In addition, in a proteinase-independent model of vesicular exocytosis, DIDS prevented stimulus

  2. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release.

    Matthew E Pamenter

    prevented stimulus-evoked release of von Willebrand Factor from human umbilical vein endothelial cells. We conclude that DIDS inhibits MMP exocytosis and through this mechanism preserves neuronal membrane integrity during pathological stress.

  3. Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro.

    Spallarossa, Paolo; Garibaldi, Silvano; Altieri, Paola; Fabbi, Patrizia; Manca, Valeria; Nasti, Sabina; Rossettin, Pierfranco; Ghigliotti, Giorgio; Ballestrero, Alberto; Patrone, Franco; Barsotti, Antonio; Brunelli, Claudio

    2004-10-01

    The clinical use of doxorubicin, a highly active anticancer drug, is limited by its severe cardiotoxic side effects. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity of doxorubicin. Carvedilol is an adrenergic blocking agent with potent anti-oxidant activity. In this study we investigated whether carvedilol has protective effects against doxorubicin-induced free radical production and apoptosis in cultured cardiac muscle cells, and we compared the effects of carvedilol to atenolol, a beta-blocker with no anti-oxidant activity. Reactive oxygen species (ROS) generation in cultured cardiac muscle cells (H9c2 cells) was evaluated by flow cytometry using dichlorofluorescein (DCF) and hydroethidine (HE). Apoptosis was assessed by measuring annexin V-FITC/propidium iodide double staining, DNA laddering, levels of expression of the pro-apoptotic protein Bax-alpha and the anti-apoptotic protein Bcl-2, and caspase-3 activity. Pre-treatment with carvedilol significantly attenuated the doxorubicin-induced increases in DCF (P carvedilol) and HE (P carvedilol reduced the number of positive fluorescent cells (P Doxorubicin-induced DNA fragmentation to a clear ladder pattern, while carvedilol prevented DNA fragmentation. Doxorubicin-induced a fall in mRNA expression of the anti-apoptotic Bcl-2 and an increase in the expression of the pro-apoptotic Bax-alpha. Carvedilol pre-treatment blunted both the decrease of Bcl-2 (P carvedilol partially inhibited the doxorubicin-induced activation of caspase-3 (P preventing doxorubicin-induced ROS generation and cardiac apoptosis. Our results suggest that carvedilol is potentially protective against doxorubicin cardiotoxicity by decreasing free radical release and apoptosis in cardiomyocytes.

  4. Ações de enfermagem para a prevenção da extubação acidental Intervenciones de enfermería para la prevención de la extubación accidental Nursing interventions for the prevention of accidental extubation

    Théia Maria Forny Wanderley Castellões

    2009-08-01

    Full Text Available RESUMO: Objetivo foi apresentar os resultados parciais da incidência da extubação acidental associada ao cuidado de enfermagem. MÉTODO: estudo observacional retrospectivo, de intervenção prospectiva, medindo antes e depois da implantação de um guia as extubações acidentais A população de 142 pacientes,sendo 72 pacientes na fase retrospectiva e 70 na fase prospectiva,totalizando 3771 dias de ventilação. Dados coletados de prontuários. RESULTADOS: 52,78% usavam tubo traqueal e 62% tinham entre 71 e 90 anos com média de dias de ventilação de 26,5 dias,. Ocorreram seis (3,27 extubações antes e duas (1,03 após a implantação do guia. CONCLUSÕES, houve diminuição da incidência da extubação acidental no período estudado, mas não se pode atribuir ao guia esta diferença pois são necessários outros estudos.OBJETIVO: presentar los resultados parciales de la incidencia de la extubación accidental relacionada al cuidado de Enfermería. MÉTODO: estudio observacional retrospectivo de intervención prospectiva, midiendo antes y después de un protocolo las extubaciones accidentales. LA población fue de 142 pacientes, siendo 72 en el periodo retrospectivo y 70 en el prospectivo, haciendo 3771 días de ventilación. Datos colectados de prontuarios. RESULTADOS : 52,78% usavam tubo traqueal y 62% tenian entre 71 y 90 anos com 26,5 média de dias de ventilación. Ocurrieron seis (3,27 extubaciones antes y dos (1,03 después de la implantación del protocolo. CONCLUSIONES, hubo disminución de la incidencia de la extubación accidental en el período estudiado, pero no se pode atribuir al guía esta diferenza pues son necesarios otros estudios.The objective was to analyze results of the incidence of accidental extubation associated with nursing care. METHOD: Retrospective observational study, the intervention ahead, measured before and after the deployment of a guide extubations accidental The population of 142 patients, 72

  5. Accidental release of iodine 131 by the IRE of the Fleurus site: return on experience by the Belgian safety authority; Rejet accidentel d'iode-131 par l'ire sur le Site de Fleurus: retour d'experience de l'Autorite de Surete Belge

    Vandecasteele, C.M.; Sonck, M. [AFCN - Agence Federale de Controle Nucleaire, Rue Ravenstein 36, B-1000 Bruxelles (Belgium); Degueldre, D. [Bel V, Rue Walcourt 148, B-1070 Anderlecht, Bruxelles (Belgium)

    2010-07-01

    After a presentation of the activities of the IRE, the Belgian National Institute of Radio-elements, i.e. the production of radionuclides used in nuclear medicine, this report describes the process and chemical reaction which caused an accidental release of iodine 131. It analyzes the causes of this incident, and how the incident has been managed by the Belgian safety authority. It discusses the first assessment of radiological consequences, describes how the incident has been managed at the federal level, and how population and media have been informed. It discusses the actual radiological consequences through measurements performed on grass and vegetables (graphs and maps indicate contamination levels and contaminated areas), and through the assessment of exposure of adults and children by different ways. Lessons learned are then discussed

  6. Prevention of invasive fungal infections in immunocompromised patients: the role of delayed-release posaconazole.

    Soysal, Ahmet

    2015-01-01

    Posaconazole is a triazole antifungal agent that has broad-spectrum activity against many yeasts and filamentous fungi, including Candida species, Cryptococcus neoformans, Aspergillus species, and Zygomycetes. This drug has been approved for the prevention of invasive fungal infections in patients with neutropenia and for the treatment of invasive fungal infections in hematopoietic stem cell transplant recipients with graft-versus-host disease. Studies on the clinical efficacy, safety, tolerability, and cost-effectiveness of posaconazole therapy were performed using the oral suspension form of the drug. Pharmacokinetic studies have found that the oral suspension form of posaconazole has problemeatic bioavailability: its absorption is affected by concomitant medication and food. This article discusses the pharmacokinetic properties of the newly developed posaconazole delayed-release tablet formulation and reviews the efficacy, safety, and cost-effectiveness of both the oral suspension and the new tablet formulation. In conclusion, the posaconazole tablet formulation has better systemic bioavailability, thereby enabling once-daily administration and better absorption in the presence of concomitant medication and food. However, well-designed clinical studies are needed to evaluate the use of the tablet formulation in real-life settings.

  7. 14 CFR 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    2010-01-01

    ... sensitive but unclassified (SBU) information/material to the news media. 1213.107 Section 1213.107... INFORMATION MEDIA § 1213.107 Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the news media. (a) All NASA SBU information requires accountability and approval for...

  8. Conceptual Design of Portable Filtered Air Suction Systems For Prevention of Released Radioactive Gas under Severe Accidents of NPP

    Gu, Beom W.; Choi, Su Y.; Yim, Man S.; Rim, Chun T. [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    It becomes evident that severe accidents may occur by unexpected disasters such as tsunami, heavy flood, or terror. Once radioactive material is released from NPP through severe accidents, there are no ways to prevent the released radioactive gas spreading in the air. As a remedy for this problem, the idea on the portable filtered air suction system (PoFASS) for the prevention of released radioactive gas under severe accidents was proposed. In this paper, the conceptual design of a PoFASS focusing on the number of robot fingers and robot arm rods are proposed. In order to design a flexible robot suction nozzle, mathematical models for the gaps which represent the lifted heights of extensible covers for given convex shapes of pipes and for the covered areas are developed. In addition, the system requirements for the design of the robot arms of PoFASS are proposed, which determine the accessible range of leakage points of released radioactive gas. In this paper, the conceptual designs of the flexible robot suction nozzle and robot arm have been conducted. As a result, the minimum number of robot fingers and robot arm rods are defined to be four and three, respectively. For further works, extensible cover designs on the flexible robot suction nozzle and the application of the PoFASS to the inside of NPP should be studied because the radioactive gas may be released from connection pipes between the containment building and auxiliary buildings.

  9. Tuberculosis cutánea por inoculación accidental Cutaneous tuberculosis accidental inoculation

    María Ascensión Maestre Naranjo

    2009-09-01

    Full Text Available Caso clínico de una microbióloga con amplia experiencia, que sufre una inoculación accidental al manipular una cepa pura de Mycobacterium tuberculosis. Se pincha en la cara lateral externa de la falange distal del dedo índice, atravesando el guante con la aguja contaminada. (Imagen 1. La trabajadora procede de forma inmediata a la limpieza de la herida. El Servicio de Prevención, registra la inoculación como accidente de trabajo. A las tres semanas del accidente, aparece en el lugar de la inoculación una pápula eritematosa levemente dolorosa a la presión que va creciendo hasta alcanzar un tamaño de 1,5-2 cm., sin adenopatías axilares, ni clínica general. (Imagen 2 Se procede a la exéresis y biopsia de la lesión. Informe anatomopatológico: Inflamación crónica granulomatosa tuberculoide muy sugestiva de tuberculosis cutánea. Microbiología: dudosos bacilos ácido alcohol resistentes (BAAR Cultivo: positivo a Mycobacterium tuberculosis. Ambas cepas presentan la misma identidad. Diagnóstico: tuberculosis cutánea. El SPRL realiza la comunicación de Enfermedad Profesional según el RD 1299/2006, de 10 de diciembre. Se realiza valoración y seguimiento en el Servicio de Medicina Interna, iniciando tratamiento de tuberculosis.Clinical case of a microbiologist with wide experience, which is inoculated accidental when Mycobacterium's pure strain manipulates tuberculosis; it (she pricks itself in the lateral external face of the phalanx distal of the forefinger, crossing the glove with the contaminated needle. Immediate treatment of the wound. The Service of Prevention, he registers the inoculation as accident of work. To three weeks a slightly painful pápula eritematosa appears in the place of the inoculation to the pressure that is growing until a size reaches 1,5-2 cm., without adenopatías axyllaris, not general clinic. Exéresis and biopsy of the same one, pathological anatomy: chronic inflammation very suggestive granulomatosa

  10. Accidental haloperidol poisoning in children

    Mona P Gajre

    2012-01-01

    Full Text Available Haloperidol, a butyrophenone neuroleptic drug, is an antipsychotic used in the treatment of adult schizophrenia and mania. It is used in children with neurological disorders like chorea and developmental disorders such as hyperactivity. With the advent of newer selective neuroleptics use of haloperidol is now on decline. However, in adults it is still the preferred drug especially in resource challenged settings. Extrapyramidal reactions occur frequently with haloperidol predominantly as parkinsonian symptoms. There are few case reports of accidental haloperidol poisoning in children and this one of them.

  11. Reverse Estimation of Accidental Release Amounts From Fukushima Daiichi Nuclear Power Plant by Environmental Monitoring Data%利用福岛第一核电厂事故期间环境监测资料反推事故释放源项

    陈晓秋; 杨端节; 李冰

    2012-01-01

    2011年3月11日,日本福岛核事故导致放射性物质向大气环境的大规模释放.本工作利用大气数值预报模式WRFV2.2.1和大气弥散模式CALPUFF,对事故期间放射性物质的大气输运和弥散进行了模拟.应用大气释放源项的逆推算方法,结合单位释放率条件下的大气弥散模拟结果和环境监测数据,对福岛第一核电厂1到3号机组向大气环境释放的放射性核素总量进行了评估,推算的131I和137 Cs气载释放量分别为8.6×1016 Bq和8.6×1015 Bq.%The Fukushima Daiichi nuclear power plant accident on March 11, 2011 caused the month-long discharge of radioactive materials into the atmosphere. By using numerical prediction model WRFV2. 2. 1 and dispersion model CALPUFF, atmospheric transport and dispersion of radioactive materials was simulated during the accident. The method of a reverse estimation of source term into environment was applied by combining environmental monitoring data with atmospheric dispersion simulations under the assumption of unit release rate. Preliminary estimation of release amounts of 13LI and U7Cs accidentally discharged from Unit 1 through Unit 3 of the Fukushima Daiichi nuclear power plant into the atmosphere was obtained, based on the environmental monitoring data. Release amounts of 131I and l37Cs are 8. 6 X 1016 Bq and 8. 6 X 10ls Bq, respectively.

  12. Preventing Buoyant Displacement Gas Release Events in Hanford Double-Shell Waste Tanks

    Meyer, Perry A.; Stewart, Charles W.

    2001-01-01

    This report summarizes the predictive methods used to ensure that waste transfer operations in Hanford waste tanks do not create waste configurations that lead to unsafe gas release events. The gas release behavior of the waste in existing double-shell tanks has been well characterized, and the flammable gas safety issues associated with safe storage of waste in the current configuration are being formally resolved. However, waste is also being transferred between double-shell tanks and from single-shell tanks into double-shell tanks by saltwell pumping and sluicing that create new wastes and waste configurations that have not been studied as well. Additionally, planning is underway for various waste transfer scenarios to support waste feed delivery to the proposed vitrification plant. It is critical that such waste transfers do not create waste conditions with the potential for dangerous gas release events.

  13. Accidental inflation in the landscape

    Blanco-Pillado, Jose J.; Metallinos, Konstantinos [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, Medford, MA (United States); Gomez-Reino, Marta, E-mail: jose@cosmos.phy.tufts.edu, E-mail: marta.gomez-reino.perez@cern.ch, E-mail: Konstantinos.Metallinos@tufts.edu [Department of Physics, University of Oviedo, Oviedo (Spain)

    2013-02-01

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P{sup 4}{sub [1,1,1,6,9]} by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes.

  14. Accidental Inflation in the Landscape

    Blanco-Pillado, Jose J; Metallinos, Konstantinos

    2012-01-01

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P^4_[1,1,1,6,9] by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes.

  15. The Frequency of the Accidental Contamination with Laboratory Samples in Yazd Clinical Laboratories’ personnel in 2011

    Jafari, AA. (PhD

    2014-05-01

    Full Text Available Background and Objective: laboratory personnel have always accidental exposure to clinical samples, which can cause the transmission of infection. This threat can be prevented and controlled by education for the use of safety instruments. The purpose was to determine the frequency of accidental exposure to laboratory samples among Yazd laboratory personnel in 2011. Material and Methods: This descriptive cross-sectional study was conducted on 100 of Yazd clinical laboratory personnel. The data was collected, using a valid and reliable questioner, via interview and analyzed by means of SPSS software. Results: Eighty-six percent of the subjects reported an experience of accidental exposure to clinical samples, such as blood, serum and urine. The causes were carelessness (41% and work overload (29%. Needle- stick was the most prevalent injury (52% particularly in sampler workers (51% and in their hands (69%. There wasn’t significant relationship between accidental exposure to laboratory samples and the variables such as private and governmental laboratories (p=0.517, kind of employment (p=0.411, record of services (p=0.439 and academic degree (p=0.454. The subjects aged 20-29 (p=0.034 and worked in sampling unit had the highest accidental exposure. Conclusion: based on the results, inexperience of the personnel especially in sampling room, overload at work and ignorance of applying safety instruments are known as the most important reasons for accidental exposure to clinical samples. Keywords: Contamination; accidental Exposure; Infectious agents; laboratory; personnel

  16. Avalanche prevention release system GAZEX as a tool to control of snow discharge in small portions

    D. V. Tetekin

    2012-01-01

    Full Text Available GAZEX system is used in Russia from 2002 to release artificial avalanches. The experience of realization of this system in the Krasnaya Polyana region (the place of Olympic Winter Games of 2014 is described in the article in comparison with application of nowadays and earlier systems.

  17. Announcement: Release of National Association of State Public Health Veterinarians' 2016 Compendium of Animal Rabies Prevention and Control.

    2017-02-10

    The 2016 Compendium of Animal Rabies Prevention and Control was released in the March 1, 2016 issue of the Journal of the American Veterinary Medical Association (1). The Compendium's national recommendations for the prevention and control of animal rabies are intended to serve as a basis for an effective rabies control program in the United States. These recommendations facilitate standardization of control procedures across jurisdictions and are reviewed annually and updated as necessary. This announcement of the recommendations facilitates their adoption by increasing awareness among public health agencies and practitioners and makes more readily available a link to statutes and regulations in certain jurisdictions that refer directly to the Compendium language published in MMWR.

  18. Accidental methanol ingestion: Case report

    Bakker Jan

    2010-02-01

    Full Text Available Abstract Background The incidence of methanol (CH3OH intoxication differs enormously from country to country. Methanol intoxication is extremely rare in the Dutch population. Even a low dose can already be potentially lethal. Patients are conventionally treated with hemodialysis. Therefore we'd like to present a report of a foreign sailor in Rotterdam who accidentally caused himself severe methanol intoxication, with a maximum measured concentration of 4.4 g/L. Case presentation The patient presented with hemodynamic instability and severe metabolic acidosis with pH 6.69. The anion gap was 39 mmol/L and the osmol gap 73 mosmol/kg. Treatment with ethanol and continuous venovenous hemodiafiltration (CVVH-DF was initiated. Despite the hemodynamic instability it is was possible to achieve rapid correction of pH and methanol concentration with CVVH-DF while maintaining a stable and therapeutic ethanol serum concentration. Despite hemodynamic and acid-base improvement, our patient developed massive cerebral edema leading to brain death. Permission for organ donation was unfortunately not ascertained. Conclusions We conclude that in a hemodynamic instable situation high methanol concentrations and methanol-induced derangements of homeostasis are safely and effectively treated with CVVH-DF and that severe cerebral edema is another possible cause of death rather than the classical bleeding in the putamen area.

  19. Fluoride-Releasing Materials to Prevent White Spot Lesions around Orthodontic Brackets: A Systematic Review

    Nascimento,Patrícia Layane de Menezes Macêdo; Fernandes,Micaelle Tenório Guedes; de Figueiredo, Fabricio Eneas Diniz; Faria-e-Silva,André Luis

    2016-01-01

    Abstract The relation between orthodontic fixed appliances use and enamel demineralization is well established. Different preventive approaches have been suggested to this problem, but controversy remains about which is the best. The aim of this study was to perform a systematic review of clinical trials that investigated the effectiveness of materials containing fluorides to lute brackets or cover the bonding interface in order to inhibit the development and progression of white spot lesions...

  20. Development of a broad spectrum polymer-released antimicrobial coating for the prevention of resistant strain bacterial infections.

    Sinclair, K D; Pham, T X; Farnsworth, R W; Williams, D L; Loc-Carrillo, C; Horne, L A; Ingebretsen, S H; Bloebaum, R D

    2012-10-01

    More than 400,000 primary hip and knee replacement surgeries are performed each year in the United States. From these procedures, approximately 0.5-3% will become infected and when considering revision surgeries, this rate has been found to increase significantly. Antibiotic-resistant bacterial infections are a growing problem in patient care. This in vitro research investigated the antimicrobial potential of the polymer released, broad spectrum, Cationic Steroidal Antimicrobial-13 (CSA-13) for challenges against 5 × 10(8) colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA). It was hypothesized that a weight-to-weight (w/w) concentration of 18% CSA-13 in silicone would exhibit potent bactericidal potential when used as a controlled release device coating. When incorporated into a polymeric device coating, the 18% (w/w) broad-spectrum polymer released CSA-13 antimicrobial eliminated 5 × 10(8) CFU of MRSA within 8 h. In the future, these results will be utilized to develop a sheep model to assess CSA-13 for the prevention of perioperative device-related infections in vivo.

  1. Intervenção comunitária para prevenção de acidentes de trânsito entre trabalhadores ciclistas Intervención comunitaria para la prevención de accidentes de tránsito entre trabajadores ciclistas A community intervention to prevent traffic accidents among bicycle commuters

    Giancarlo Bacchieri

    2010-10-01

    intervención educacional de prevención de accidentes de tránsito con trabajadores que utilizan la bicicleta como modo de transporte. MÉTODOS: Estudio de intervención, longitudinal, con implementación escalonada, realizado en cinco urbanizaciones con características geográficas distintas en la ciudad de Pelotas, Sur de Brasil, de enero de 2006 a mayo de 2007. Fueron sorteados 42 sectores censados de dichas urbanizaciones. Todos los domicilios fueron visitados en búsqueda de trabajadores del sexo masculino que utilizasen la bicicleta como modo de transporte, resultando en una muestra de 1.133 individuos. Fueron analizados como resultados "accidentes de tránsito" y "casi-accidentes". Mensualmente, vía telefónica, los ciclistas eran interrogados con respecto a la ocurrencia de accidentes de tránsito y de "casi-accidentes". Quincenalmente, a partir del segundo mes de acompañamiento, un grupo de aproximadamente 60 ciclistas era convidado a participar de la intervención, que incluía un componente educativo (seminario y presentación de video educativo, distribución de un kit de seguridad (chaleco nocturno con reflexivo, cartilla educativa y cintas reflexivas y revisión de los frenos de la bicicleta (mantenimiento realizado al ser necesario. Regresión de Poisson, con ajuste para el efecto del tiempo, fue utilizada para medir el efecto de la intervención. RESULTADOS: Aproximadamente 45% de los ciclistas no comparecieron a la intervención. Durante el período de estudio, 9% de los individuos informaron un accidente de tránsito y 88% un casi-accidente. En total, ocurrieron 106 accidentes y 1.091 casi-accidentes. No fue observado efecto de la intervención en ambos resultados. CONCLUSIONES: La intervención propuesta no fue capaz de reducir accidentes entre trabajadores ciclistas. falta de interés en seguridad por parte de los ciclistas y factores externos, tales como infra-estructura de las vías y comportamiento de los choferes, pueden haber colaborado para ese

  2. La prevención de accidentes (3

    Chinchilla, M.

    1966-04-01

    Full Text Available The financial loss due to working accidents is very substantial, quite apart from the actual loss of human lives. Hence avoiding these accidents is a most important matter. The accident index in the various industries shows a rate of increase that is larger than should be the case in proportion to the development of the industries concerned, and the larger number of employees. The fact that these indexes are smaller in many countries, however, shows that these accidents can be considerably reduced if suitable measures are taken to avoid them. In chapter 2 of our magazine, issue no. 178, a variety of reasons were discussed that may originate accidents, although these causes are not directly linked to the accident itself. In this article mention is made of some of the measures that can be taken in the handling of cutting and welding equipment, and also of inflammable liquids, to prevent possible accidents.El peso de los accidentes de trabajo sobre la economía supone cantidades muy grandes que, independientemente del inestimable valor de una vida humana, realzan la importancia de la prevención de accidentes. Los índices de accidentes muestran en diferentes industrias un crecimiento mayor de lo que debería corresponder proporcionalmente, habida cuenta del crecimiento laboral. El hecho de que en distintos países los índices sean inferiores, demuestra que se pueden conseguir buenos frutos si se concede primordial importancia a que los trabajos se realicen con las debidas medidas de seguridad. En el Capítulo 2, número 178 de esta Revista, se detallaron diversas causas que pueden originar un accidente sin estar ligadas en forma directa con una tarea determinada. En el presente trabajo se indican algunas de las medidas que deben observarse en el manejo de los equipos de soldadura y corte, así como en el transvase de líquidos inflamables.

  3. Accidental infection of veterinary personnel with Mycobacterium tuberculosis at necropsy: a case study.

    Posthaus, H; Bodmer, T; Alves, L; Oevermann, A; Schiller, I; Rhodes, S G; Zimmerli, S

    2011-05-05

    Mycobacterium tuberculosis is the main cause of human tuberculosis. Infection in companion animals is mainly acquired from close contact to a diseased human patient and hence rarely diagnosed in countries with low tuberculosis incidence rates. Therefore the general awareness of the disease might be low. Here we report the potential risk of infection for veterinary personnel with M. tuberculosis during the clinical and pathological examination of a dog with unexpected disseminated tuberculosis. The dog had presented with symptoms of a central nervous system disease; rapid deterioration prevented a complete clinical workup, however. Post-mortem examination revealed systemic mycobacteriosis, and M. tuberculosis was identified by PCR amplification of DNA extracts from paraffin-embedded tissue sections and spoligotyping. Contact investigations among the owners and veterinary personnel using an IFN-γ release assay indicated that the index dog did not infect humans during its lifetime. Serological and IFN-γ release assay results of one of two cats in direct contact with the index dog, however, suggested that transmission of M. tuberculosis might have occurred. Importantly, all three pathologists performing the necropsy on the dog tested positive. Accidental infection was most likely due to inhalation of M. tuberculosis containing aerosols created by using an electric saw to open the brain cavity. As a consequence routine necropsy procedures have been adapted and a disease surveillance program, including tuberculosis, has been initiated. Our results highlight the importance of disease awareness and timely diagnosis of zoonotic infectious agents in optimizing work safety for veterinary personnel.

  4. 喉切除对叠式气-食管通路发音重建防治误咽的研究%Effect of whole laryngectomy on vocal reconstruction of tracheaesophageal circuit and prevention and treatment of accidental aspiration

    蒋立新; 张向博; 刘新; 孙连玉

    2003-01-01

    目的晚期喉癌行全喉切除发音重建及防误咽一直是头颈肿瘤外科攻关难题 ,研究气-食管通路发声重建防治误咽的新方法 ,评价对叠式气-食管通路发声口重建及檐状会厌 "成形术防治误咽的疗效.方法将纵形切开的气-食管漏行衣襟样对叠缝合;保留带蒂环状软骨瓣并修成会厌形状;在重建气-食管通路发声口上方将会厌形状骨片植入食道前壁粘膜下,使曲面向下凸入食管腔形成檐状会厌".结果 33例喉鳞癌术后 3,7或 12 d 拔除鼻饲管,经 6~ 11 d常规进食适应后均无误咽.随访 2~ 5年, 28例无发声口漏, 2例癌复发肺、骨转移死亡, 3例失访.结论对叠式气-食管通路发声口及"檐状会厌"有效地防治误咽.%Aim To estimate the curative effect of vocal reconstruction of tracheaesophageal passway and the brim shape epiglottis plasty.Methods A pedicel cricoid cartilage flap had been built as well as the epiglottis after total laryngectomy.A downward concave face of the brim shape epiglottis above the phonatory opening from the posterior wall of the trachea and the anterior wall of the esophagus was made.Results The nasal feeding tube was pulled out 3,7 or 12 days after operation of larynx squamous carcinoma and there was no any patient with accidental aspiration after routine eating for 6 to 11 days.Of 33 cases undergoing this operation, 27 patients had not happened food aspiration, 2 cases died due to recurrence of the carcinoma, 3 cases failed to follow up.Conclusion We consider this method not only can avoid aspiration of the food but also is advantageous to the function of speech and swallowing in different degree.

  5. Accidental Chemical Burns of Oral Mucosa by Herbicide

    S P Deo

    2012-03-01

    Full Text Available Glyphosate (GlySH is a broad spectrum, nonselective herbicide, widely used in agriculture. This case report describes a 25-year-old man presenting with extensive chemical burns and ulceration of the oral cavity as a result of accidental exposure to GlySH. This paper aims to illustrate the typical appearance of GlySH related chemical mucosal burn and to demonstrate the severity of the corrosive effect of GlySH which need team approach to prevent unfavorable sequelae such as microstomia. Keywords: Chemical burns, corrosive injury, glyphosate poisoning, herbicide, microstomia, oral mucosal burn.

  6. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats.

    Brijesh Kumar Singh

    Full Text Available Nimesulide, an anti-inflammatory and analgesic drug, is reported to cause severe hepatotoxicity. In this study, molecular mechanisms involved in deranged oxidant-antioxidant homeostasis and mitochondrial dysfunction during nimesulide-induced hepatotoxicity and its attenuation by plant derived terpenes, camphene and geraniol has been explored in male Sprague-Dawley rats. Hepatotoxicity due to nimesulide (80 mg/kg BW was evident from elevated SGPT, SGOT, bilirubin and histo-pathological changes. Antioxidants and key redox enzymes (iNOS, mtNOS, Cu/Zn-SOD, Mn-SOD, GPx and GR were altered significantly as assessed by their mRNA expression, Immunoblot analysis and enzyme activities. Redox imbalance along with oxidative stress was evident from decreased NAD(PH and GSH (56% and 74% respectively; P<0.001, increased superoxide and secondary ROS/RNS generation along with oxidative damage to cellular macromolecules. Nimesulide reduced mitochondrial activity, depolarized mitochondria and caused membrane permeability transition (MPT followed by release of apoptotic proteins (AIF; apoptosis inducing factor, EndoG; endonuclease G, and Cyto c; cytochrome c. It also significantly activated caspase-9 and caspase-3 and increased oxidative DNA damage (level of 8-Oxoguanine glycosylase; P<0.05. A combination of camphene and geraniol (CG; 1:1, when pre-administered in rats (10 mg/kg BW, accorded protection against nimesulide hepatotoxicity in vivo, as evident from normalized serum biomarkers and histopathology. mRNA expression and activity of key antioxidant and redox enzymes along with oxidative stress were also normalized due to CG pre-treatment. Downstream effects like decreased mitochondrial swelling, inhibition in release of apoptotic proteins, prevention of mitochondrial depolarization along with reduction in oxidized NAD(PH and increased mitochondrial electron flow further supported protective action of selected terpenes against nimesulide toxicity. Therefore

  7. Mortalidad intrahospitalaria por accidente cerebrovascular

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  8. Radioecological studies on terrestrial food chain analysis for accidental release

    Choi, Yong Ho; Lee, Jeong Ho; Lee, Hyun Duk [and others

    2000-03-01

    For investigating the contamination pathways of major radionuclides in staple food crops, greenhouse experiments in which rice, Chines cabbage and radish were exposed to mixed {gamma} radionuclides of Mn-54, Co-60, Sr-85, Ru-103 and Cs-134 and H-3 at different growth stages, were conducted to generate data on parameters concerning the direct contamination of those crops. Experiments of the exposure to iodine gas were also performed for rice and radish at their various growth stages to obtain contamination parameters of elemental iodine. Based on data obtained from the experiments mentioned above, a database program was constructed to make it possible to search parameter values for different radionuclides, crops and deposition times in an easy way have an graphic output of the variation in the contamination parameter with deposition times. Paddy-field soils were collected from 5 or 6 places around Kori and Youngkwang NPPs and physicochemical properties and background radioactivity levels of the soils were investigated. Soil-to-rice transfer factors of Sr-90 and Cs-137 in the collected soils were determined for different RI application times. For Kori soils, transfer factors were also measured in the second year to investigate the yearly variation. In addition, the conceptual design of an automatized experimental greenhouse was performed to be used as a basic material for a detailed design for the construction in the future.

  9. Environmental Behaviour of Plutonium Accidentally Released at Thule, Greenland

    Aarkrog, Asker

    1977-01-01

    . Plutonium concentrations down through the sediment layers decayed exponentially with a half-depth of 1-2 cm. The horizontal distribution of the plutonium may be described by an exponential expression: mCi 239,240Pn km-2 = 460e-0.28R or by a power function: mCl 239,240Pu km-2 = 370 R-1.2, where R...

  10. Prevenção de queimaduras: percepção de pacientes e de seus familiares Prevención de accidentes por quemaduras: percepción del paciente y de sus familiares Burn prevention: perceptions of patients and their relatives

    Lídia Aparecida Rossi

    2003-02-01

    éstico. De las 57 entrevistas, 11 afirmaron que no podrían haber contribuido para evitar el accidente que provocó la quemadura. Veinte pacientes y 12 familiares identificaron situaciones de riesgo en el ambiente doméstico o en el trabajo; 13 pacientes y 12 familiares no identificaron ningún tipo de situación de riesgo. Los familiares y pacientes resaltaron como medidas preventivas de accidentes por quemaduras: estar atento a las actividades y tener cuidado en el manejo de productos inflamables.This study aimed at investigating the ways to prevent burns identified by burned patients and their relatives. Data were collected at the Burns Unit of the Ribeirão Preto Medical School Clinical Hospital, University of São Paulo - Brazil by means of interviews with burned patients and their relatives. Four referees categorized data. In order to verify the existence of agreement among the referees with regard to categorization, the non-parametric correlation measure was used - Contingency Coefficient. Fifty-seven people were interviewed: 24 relatives and 33 burned patients. Of the 33 interviewed patients, 18 had suffered accidents at home. Of the 57 interviewees, 11 stated that they could not have avoided the accident causing the burn. Twenty patients and 12 relatives identified risk situations at home or at work and 13 patients and 12 relatives did not identify any types of risk situations. The relatives and patients referred to the following preventive measures for burning accidents: to be attentive to the activities that they perform and to be more careful while handling flammable products.

  11. Insertion of an intrathecal catheter following accidental dural puncture : a meta-analysis

    Heesen, M.; Kloehr, S.; Rossaint, R.; Walters, M.; Straube, S.; van de Velde, M.

    2013-01-01

    Background: Inserting an intrathecal catheter after accidental dural puncture in parturients to prevent postdural puncture headache is becoming increasingly popular. We aimed to identify relevant published articles investigating this intervention and subject data to a meta-analysis. Methods: A syste

  12. Inhaled Surfactant in the treatment of accidental Talc Powder inhalation: a new case report

    Lo Piparo Caterina

    2011-09-01

    Full Text Available Abstract The use of talcum powder is incorrectly part of the traditional care of infants. Its acute aspiration is a very dangerous condition in childhood. Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported. We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the benefits of surfactant administration. Surfactant contributed to the rapid improvement of the medical and radiological condition, preventing severe early and late complications and avoiding invasive approaches.

  13. Accidental fire in the West Hall

    1977-01-01

    On January 7 an accidental fire due to the failure of standard circuit-breakers, destroyed the coils of two spectrometer magnets and severely damaged the apparatus of two experiments. See also photos 7701582X, 7701581X, 7701580X. (Annual Report 1977, pg. 127-128)

  14. [Management of accidental internal exposure].

    Fatome, M

    1994-11-01

    Radionucleides can penetrate into the body via the lung, the digestive tract, wounds and sometimes through healthy skin. Once they have penetrated the body, they can either remain localized at the site of entry or be rapidly metabolized. The risk is late effects. Radioelements must be eliminated as rapidly as possible decreasing the exposure proportionally. The effectiveness of the treatment depends on early institution. Nevertheless, emergency intensive care or surgery may be required. As soon as possible, explorations must be carried out to evaluate the level of contamination (human spectrometry, radiotoxicological examinations) and to start treatment. Modalities include non-specific techniques (lavage, insolubilization, laxatives) and specific techniques such as complexation or isotopic dilution (iodine for iodine, Prussian blue for cesium, DTPA for plutonium, Diamox or sodium bicarbonate for uranium). Surgical cleaning of wounds and burns is an excellent means of decontamination. External contamination is often associated. Further contamination must be prevented immediately.

  15. [Accidental falls in the elderly].

    Heinimann, Niklas B; Kressig, Reto W

    2014-06-18

    Falls in the elderly are common with consecutive high mortality and morbidity. Recent consecutive data focus on identification and therapy of intrinsic risk factors. Sarcopenia, imbalance and gait disorders represent the major risk factors. Sarcopenia is caused by a disequilibrium of protein synthesis and breakdown, probably in consequence of age-related changes in protein metabolism. Protein supplements in combination with strength training shows the best benefit. Disorders in balance and gait are caused by age-related or pathologic changes in a complex regulation system of gait. The individual fall risk correlates with the gait variability and even increases with bad dual task performance. Activities with high requirements of attention and body awareness are the most effective prevention for falls in the elderly (-50%).

  16. Accidental childhood death and the role of the pathologist.

    Byard, R W

    2000-01-01

    The following study provides an overview of accidental childhood death. This study is based on a review of 369 cases of fatal childhood accidents taken from the records of the Department of Histopathology, Women's and Children's Hospital, Adelaide, Australia, over a 34-year period from 1963 to 1996. Data provide information on deaths due to motor vehicle accidents, drownings, accidental asphyxia, burns, poisonings, electrocution, and miscellaneous trauma. In addition, certain categories have undergone further examination, including asphyxial deaths due to unsafe sleeping environments and unsafe eating practices, drowning deaths, and deaths on farms, following identification of significant child safety problems in these areas as part of the "Keeping Your Baby and Child Safe" program. Previously unrecognized dangers to children detected through this program include mesh-sided cots, V-shaped pillows, and certain types of stroller-prams. The production of information pamphlets and packages for parents and the recall of certain dangerous products following recommendations made by pathologists demonstrate that pediatric and forensic pathologists have an important role to play in preventive medicine issues and in formulating public health strategies.

  17. 5 CFR 870.206 - Accidental death and dismemberment.

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Types and Amount of Insurance § 870..., accidental death benefits are equal to the amount of Option A. (c)(1) Under Basic insurance, accidental... automatic part of Basic and Option A insurance for employees. (2) There is no accidental death...

  18. Accidental ingestion of Ecstasy in a toddler.

    Chang, Yi-Jung; Lai, Ming-Wei; Kong, Man-Shan; Chao, Hsun-Chin

    2005-12-01

    Toddlers who ingest the drug of abuse 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are at particularly high risk of serious neurological and cardiovascular side effects. We report of a 20-month-old male toddler who accidentally ingested Ecstasy. He presented with fever and seizures, tachycardia, hypertension, and hyperthermia. Urine amphetamine level was 2111 ng/mL. Treatment included rapid cooling, hydration, and support measures. Vital signs were regularly monitored. His condition became stable on day 2 and urine amphetamine level returned to normal on day 3 of hospitalization. His behavior, activity, and appetite had returned to their usual levels upon follow-up at our outpatient clinic. The incidence of drug abuse with MDMA has increased dramatically over the last decade in developed countries. It can be expected that accidental Ecstasy poisoning in children will increase as well. This case illustrates the need to consider the possibility of accidental Ecstasy ingestion in the differential diagnosis of a child suffering from convulsions with fever.

  19. Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

    Dang, Nhung T T; Sivakumaran, Haran; Harrich, David; Shaw, Paul N; Davis-Poynter, Nicholas; Coombes, Allan G A

    2014-10-01

    Polycaprolactone (PCL) matrices were simultaneously loaded with the antiviral agents, tenofovir (TFV) and nevirapine (NVP), in combination to provide synergistic activity in the prevention of HIV transmission through the vaginal route. TFV and NVP were incorporated in PCL matrices at theoretical loadings of 10%TFV-10% NVP, 5%TFV-5%NVP and 5%TFV-10%NVP, measured with respect to the PCL content of the matrices. Actual TFV loadings ranged from 2.1% to 4.2% equating to loading efficiencies of about 41-42%. The actual loadings of NVP were around half those of TFV (1.2-1.9%), resulting in loading efficiencies ranging from 17.2% to 23.5%. Approximately 80% of the initial content of TFV was released from the PCL matrices into simulated vaginal fluid (SVF) over a period of 30 days, which was almost double the cumulative release of NVP (40-45%). The release kinetics of both antivirals over 30 days were found to be described most satisfactorily by the Higuchi model. In vitro assay of release media containing combinations of TFV and NVP released from PCL matrices confirmed a potential synergistic/additive effect of the released antivirals on HIV-1 infection of HeLa cells. These findings indicate that PCL matrices loaded with combinations of TFV and NVP provide an effective strategy for the sustained vaginal delivery of antivirals with synergistic/additive activity.

  20. Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging.

    Isaac, Vera Lucia Borges; Chiari-Andréo, Bruna Galdorfini; Marto, Joana Marques; Moraes, Jemima Daniela Dias; Leone, Beatriz Alves; Corrêa, Marcos Antonio; Ribeiro, Helena Margarida

    2015-01-01

    The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation. In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid. Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging. The rheological and mechanical behavior and the in vitro release profile were assayed. The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA.

  1. Application of quality control circle management in the prevention of accidental prolapse of gastric tube in patients with cerebral-vascular disease%品管圈管理预防脑血管病患者胃管意外滑脱的效果

    马虹颖; 杨存美; 冯瑞娟

    2014-01-01

    目的:探讨品管圈管理在预防脑血管病患者胃管滑脱中的作用。方法成立品管圈,应用头脑风暴法确立预防胃管滑脱为活动的主题,拟定计划,分析现状,统计绘制柏拉图及鱼骨图分析原因,针对3项主要原因设定目标,制定对策,将实施对策进行效果确认、标准化,修改并制定科室的胃管管理制度。结果实施措施后我科脑血管留置胃管患者拔管率由27.5%(55/200)降低至5.0%(10/200),差异有统计学意义(χ2=27.05,P<0.01);设定的目标值均已达到,目标达成率115%,进步率81%。圈员责任心、自信心、积极性、解决问题的能力、团队凝聚力等方面的能力得到提升。结论品管圈管理研究了影响胃管滑脱的主要因素,制定了切实有效的预防措施,有效解决了胃管滑脱的问题,提高了护士的综合素质,提高了临床护理质量。%Objective To investigate the effect of quality circle control ( QCC ) management in the prevention of accidental prolapse of gastric tube in patients with cerebral -vascular disease .Methods First, we set up the quality control circle , identified the theme , analyzed the current situation and drew the Pareto diagram and fishbone diagram to find out the three main causes .Then we set up the goals and developed strategies .At last we confirmed and standardized the results , modified and formulated the tube management system . Results After applying the QCC management , the extubation rate significantly reduced from 27.5%(55/200) to 5.0%(10/200) (χ2 =27.05,P<0.01), with an achievement rate of 115%and progress rate of 81%.The responsibility, self-confidence, initiative, problem solving ability, team cohesion, communicate and coordinated ability, happiness and quality control means had improved after the application of QCC management . Conclusions The application of QCC management can effectively solve the

  2. Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

    Notario-Pérez, Fernando; Martín-Illana, Araceli; Cazorla-Luna, Raúl; Ruiz-Caro, Roberto; Bedoya, Luis-Miguel; Tamayo, Aitana; Rubio, Juan; Veiga, María-Dolores

    2017-01-01

    The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit® RS. This paper assesses the potential of chitosan for the development of sustained-release vaginal tablets of Tenofovir and compares it with different polymers. The parameters assessed were the permanence time of the bioadhesion—determined ex vivo using bovine vaginal mucosa as substrate—the drug release profiles from the formulation to the medium (simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow the manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a sustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and may be useful for the prevention of sexual transmission of HIV. PMID:28230790

  3. The present status and recent applications of the accidental tritium assessment code UFOTRI

    Raskob, W. [Forschungszentrum Karlsruhe GmbH, Institut fuer Neutronenphysik und Reaktortechnik, Karlsruhe (Germany)

    1999-03-01

    The computer program UFOTRI can be used for assessing the impact of accidental released tritium in the two chemical forms tritiated water vapour and tritium gas. By applying UFOTRI to potential European sites for ITER, it could be demonstrated that the main goal, the nonevacuation criteria, is fulfilled for the present release limits. Contributions in international studies together with the re-evaluation of experimental data showed that the plant sub-model as well as the soil sub-model are areas for further improvement. (author)

  4. Accidental K\\"ahler Moduli Inflation

    Maharana, Anshuman; Sumitomo, Yoske

    2015-01-01

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small K\\"ahler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil K\\"ahler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model.

  5. Accidental Kähler moduli inflation

    Maharana, Anshuman [Harish Chandra Research Institute,Chhatnag Road, Jhunsi, Allahabad, UP 211019 (India); Rummel, Markus [Rudolph Peierls Centre for Theoretical Physics, University of Oxford,1 Keble Road, Oxford, OX1 3NP (United Kingdom); Sumitomo, Yoske [High Energy Accelerator Research Organization, KEK,1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2015-09-14

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small Kähler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil Kähler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model.

  6. Anaphylaxis after accidental ingestion of kiwi fruit.

    Gawrońska-Ukleja, Ewa; Różalska, Anna; Ukleja-Sokołowska, Natalia; Zbikowska-Gotz, Magdalena; Bartuzi, Zbigniew

    2013-06-01

    Numerous cases of anaphylaxis after ingestion of kiwi fruit, after the skin tests and during oral immunotherapy were described. The article describes the case of severe anaphylactic reaction that occurred in a 55-year-old patient after accidental ingestion of kiwi. Allergy to kiwi fruit was confirmed by a native test with fresh kiwi fruit. After the test, the patient experienced generalized organ response in the form of headache, general weakness and rashes on the neck and breast, and dyspnea. The patient had significantly elevated levels of total IgE and IgE specific to kiwi fruit.

  7. Tratamiento del virus de hepatitis B en el accidente laboral

    Henry Zamora-Barquero

    2008-11-01

    Full Text Available La exposición accidental al virus B entraña alto riesgo de contagio de la enfermedad. Su manejo incluye: medidas preventivas en el manejo de los pacientes, vacunar y confirmar inmunidad de los trabajadores, uso de inmunoglobulinas y vacunación posterior al accidente y disponer de protocolos de reporte precoz y clínicas en el manejo de los accidentes.

  8. Outcome of accidental hypothermia with or without circulatory arrest

    Wanscher, Michael; Agersnap, Lisbeth; Ravn, Jesper;

    2012-01-01

    Resuscitation guidelines for the treatment of accidental hypothermia are based primarily on isolated cases. Mortality rates are high despite aggressive treatment aimed at restoring spontaneous circulation and normothermia....

  9. El accidente de trabajo "in itinere": concepto legal y jurisprudencial

    López Mejías, Ana

    2016-01-01

    El trabajo que voy a llevar a cabo trata sobre el accidente de trabajo, más en concreto el accidente de trabajo "in itinere", ya que es un hecho protegido que la ley general de la seguridad social le da una gran importancia. Trataré los requisitos necesarios para que se dé un accidente de trabajo "in itinere", basándome siempre en sentencias ya que es un trabajo básicamente jurisprudencial. En el trabajo también trato el accidente de trabajo in mision. A modo de conclusión expresaré mi opinió...

  10. Accidentes de tránsito terrestre

    José Enrique Ramírez Muñoz

    2013-09-01

    Full Text Available Los accidentes de tránsito terrestres en Costa Rica se han convertido en un serio problema de salud pública, que derivan ya sea en lesiones graves o bien en muertes de personas de todas las edades. Estos eventos incluyen el atropellamiento, las colisiones y choques, y producen cuadros lesionológicos muy diversos de acuerdo a la participación de las personas, el tipo de vehículo y la forma en la que se produce el traumatismo. Así mismo, se debe tener en cuenta la participación de factores coadyuvantes como el uso del casco y el cinturón de seguridad, o bien el consumo de alcohol y el uso del teléfono móvil. La valoración médico legal de las víctimas, vivas o muertas de accidentes de tránsito, está a cargo del Departamento de Medicina Legal del Organismo de Investigación Judicial, y se hace por solicitud de una Autoridad Judicial competente.

  11. Consequence Analyses Following Potential Savannah River Site Hydrological Releases

    Blanchard, A.

    1999-07-28

    Postulated accidental release of radiological material to surface water bodies on the Savannah River Site and the resulting downstream contamination of the Savannah River pose a potential threat to downstream river users.

  12. Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study.

    Alfaro-Rodriguez, Alfonso; Alonso-Spilsbury, María; Arch-Tirado, Emilio; Gonzalez-Pina, Rigoberto; Arias-Montaño, José-Antonio; Bueno-Nava, Antonio

    2013-09-27

    Histamine H3 receptors (H3Rs) co-localize with dopamine (DA) D1 receptors (D1Rs) on striatal medium spiny neurons and functionally antagonize D1R-mediated responses. The intra-striatal administration of D1R agonists reduces DA release whereas D1R antagonists have the opposite effect. In this work, a microdialysis method was used to study the effect of co-activating D1 and H3 receptors on the release of DA from the rat dorsal striatum. Infusion of the D1R agonist SKF-38393 (0.5 and 1 μM) significantly reduced DA release (26-58%), and this effect was prevented by co-administration of the H3R agonist immepip (10 μM). In turn, the effect of immepip was blocked by the H3R antagonist thioperamide (10 μM). Our results indicate that co-stimulation of post-synaptic D1 and H3 receptors may indirectly regulate basal DA release in the rat striatum and provide in vivo evidence for a functional interaction between D1 and H3 receptors in the basal ganglia.

  13. Construção da participação comunitária para a prevenção de acidentes domésticos infantis Construcción de la participación comunitaria para prevenir accidentes domesticos infantiles Constructing community involvement for the prevention of home accidents in children

    Justina Inês Brunetto Verruck Acker

    2009-02-01

    ámica ¿Qué es eso?, y la dinámica Casa Simulada. CONSIDERACIONES: Se evidencia que con creatividad y congruencia el grupo de salud ha desencadenado el proceso de movilización de la comunidad para prevenir accidentes domésticos infantiles.INTRODUCTION: This paper reports part of a study whose aim was to mobilise a team for the Family Health Program to enable the citizen community involvement aiming at preventing domestic accidents for children under age five, through the theoretical framework of the Seven Theses by Roberto Briceño-Léon. METHODOLOGY: the Convergent Care Research was used with a Team for the Family Health Programme in a town in the country in Rio Grande do Sul. Educational workshops were first performed with the team and then educational activities were done with the families in the community. Data were collected through the observation, interview and content analysis. RESULTS: Creation of four educational tools: the song 'A Lição do Sapeca', dramatisation of the song, the practice called 'O que é isto?' and the practice called 'Casa Simulada'. CONSIDERATIONS: It is showed that through creativity and congruence the health team unleashed a process of the citizen community involvement for preventing child domestic accidents.

  14. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

    2014-10-01

    of nitrous oxide. We recommend that an anaesthetic checklist, to be an integral part of the World Health Organization Safer Surgery checklist, is introduced as an aid to preventing accidental awareness. This paper is a shortened version describing the main findings from NAP5--the full report can be found at http://www.nationalauditprojects.org.uk/NAP5_home.

  15. 21 CFR 1002.20 - Reporting of accidental radiation occurrences.

    2010-04-01

    ... Occurrences § 1002.20 Reporting of accidental radiation occurrences. (a) Manufacturers of electronic products... the Director, Center for Devices and Radiological Health, all accidental radiation occurrences... radiation occurrence occurred; (3) The manufacturer, type, and model number of the electronic product...

  16. Course Management Systems for Learning: Beyond Accidental Pedagogy

    McGee, Patricia; Carmean, Colleen; Jafari, Ali

    2005-01-01

    "Course Management Systems for Learning: Beyond Accidental Pedagogy" is a comprehensive overview of standards, practices and possibilities of course management systems in higher education. "Course Management Systems for Learning: Beyond Accidental Pedagogy" focuses on what the current knowledge is (in best practices, research, standards and…

  17. Tension pneumothorax following an accidental kerosene poisoning: A case report

    G M Ashir

    2009-01-01

    Full Text Available Tension pneumothorax is a rare complication following an accidental kerosene poisoning. In such situation, a bed-side needle thoracocentesis is performed because of its potential of becoming fatal; hence its clinical importance. A case of 15 month old boy with tension pneumothorax following accidental kerosene poisioning that responded to needle thoracocentesis is presented.

  18. Tension pneumothorax following an accidental kerosene poisoning: A case report

    2009-01-01

    Tension pneumothorax is a rare complication following an accidental kerosene poisoning. In such situation, a bed-side needle thoracocentesis is performed because of its potential of becoming fatal; hence its clinical importance. A case of 15 month old boy with tension pneumothorax following accidental kerosene poisioning that responded to needle thoracocentesis is presented.

  19. Research progress in study of accidental hypothermia

    Rui YUAN

    2016-04-01

    Full Text Available Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypothermia. A series of rewarming measures, such as infusion of warm fluids, inspiration of warm air, abdominal infusion of warm fluid, instruction of warm fluid into pleural cavity, intravenous infusion of warm fluid, rewarming through ECMO, etc. have been used recently. Advance in research on the classification of hypothermia, its impact to the body and the treatment methods are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2016.04.15

  20. Accidental Contamination with Oil during Endodontic Surgery

    Plascencia, Hugo; Díaz, Mariana; Cholico, Patricia; del Real, Monserrat; Márquez-de Alba, Salvador

    2016-01-01

    The modern surgical endodontic treatment is a safe and predictable procedure with high success rate. However, several factors can retard or impede the proper healing process. Use of a high speed handpiece during hard tissues management (osteotomy and apical resection) can potentially be one of these factors. Formation of metallic debris from the surgical diamond burs, production of necrotic local tissue due to overheating and the direct liberation of air from conventional handpiece into the working area are potential irritants able to delay the tissue healing. The aim of the present article is to report the histopathological findings of the trans-operational accidental contamination with oil in the surgical area during an endodontic surgery. PMID:27790269

  1. Rickettsial infection caused by accidental conjunctival inoculation

    Brissos, Joao; de Sousa, Rita; Santos, Ana Sofia; Gouveia, Catarina

    2015-01-01

    The most common transmission route of tick-borne Rickettsia is through tick bite; nevertheless, other transmission routes should also be considered. We report a case of rickettsial infection in a 15-year-old boy caused by accidental contamination of the conjunctiva through the infected fluid of a crushed engorged tick removed from a dog. Right eye pain, conjunctival hyperaemia with mucopurulent exudate, chemosis and eyelid oedema were the first signs and symptoms. Two days later, the boy developed fever, myalgia, headache, abdominal pain and was vomiting; physical examination showed multiple cervical adenopathies but no rash. He was treated with doxycycline (200 mg/day) for 7 days with progressive resolution of clinical signs. Rickettsial infection was confirmed by immunofluorescence assay with serological seroconversion in two consecutive samples. Rickettsia conorii or Rickettsia massiliae were the possible causal agents since they are the Rickettsia spp found in the Rhipicephalus sanguineus dog tick in Portugal. PMID:25568272

  2. Causes of accidental childhood deaths in China in 2010

    Chan, Kit Yee; Yu, Xin-Wei; Lu, Jia-Peng

    2015-01-01

    BACKGROUND: Infectious causes of childhood deaths in the world have decreased substantially in the 21st century. This trend has exposed accidental deaths as an increasingly important future challenge. Presently, little is known about the cause structure of accidental childhood deaths in low......- and middle-income country (LMIC) settings. In this paper, we aim to establish cause structure for accidental deaths in children aged 0-4 years in China in the year 2010. METHODS: In this paper, we explored the database of 208 multi-cause child mortality studies in Chinese that formed a basis for the first...... published estimate of the causes of child deaths in China (for the year 2008). Only five of those studies identified specific causes of accidental deaths. Because of this, we searched the Chinese medical literature databases CNKI and WanFang for single-cause mortality studies that were focused on accidental...

  3. [Levonorgestrel-releasing intrauterine system Mirena® (Bayer) for the prevention and treatment of endometrial adenocarcinoma and the incidence of other malignancies in women].

    Jóźwik, Maciej; Jóźwik, Marcin; Modzelewska, Beata; Niewińska, Marta; Jóźwik, Michał

    2015-04-01

    The use of hormone-releasing intrauterine devices has been on the increase for the last three decades. To date, evidence of their long-term efficiency is available. The aim of the present paper was to briefly review beneficial prophylactic effects of the levonorgestrel-releasing intrauterine system on the incidence of a variety of malignancies in women. Such an influence is of a particular importance in the light of the currently observed increased prevalence of endometrial and cervical adenocarcinomas. Low-dose releasing intrauterine systems are also available, but the hard evidence-based medical data have been derived primarily for Mirena® (Bayer) device, which topically releases from 20 to 14 pg of levonorgestrel daily. Consequently the risk of developing endometrial carcinoma in Mirena® users is lowered by as much as 50% compared with the general population risk To a lesser extent, the intrauterine system decreases the risk for cervical adenocarcinoma and squamous cell carcinoma, as well as ovarian, pancreas, and lung carcinomas. In one population-based study Mirena® increased the risk for breast carcinoma by approximately 20%, whereas a number of other studies failed to demonstrate such a hazard. In the recent decades of the increased predominance of insulin resistance and obesity and an occurrence of hormone-dependent carcinomas at earlier age, a broad application of levonorgestrel-releasing intrauterine systems may become a particularly important component of primary prevention of malignancies in women. Both obese and overweight patients seem perfect candidates for such a hormonal intervention.

  4. [The prevalence of accidental poisoning in a hospital pediatric unit of Latium].

    Faraoni, F; Protano, C; Bini, V; Lizzi, R

    2006-01-01

    The aim of this study was to investigate the trend of accidental poisoning among children, over a period of fifteen years, from 1990 to 2004, in the pediatric wards of a hospital in Latium (Italy). The prevalence of childhood poisoning was calculated based on the medical records of the pediatric unit of the hospital. The derived data was divided into different categories according to age, gender and types of poisoning. The results of this study show a decrease in accidental pediatric poisoning; according to the literature the frequency of poisoning was higher in males, under the age of 2 years, than females. Trends show an increase in pharmaceutical poisonings. The present study underlines the need for continuous information on prevention and educational programs organized by the Institutions, territorial sanitary services and GP with the aim of increasing the awareness of parents regarding the risk factors of poisoning.

  5. Hipotermia accidental secundaria a brote de psoriasis generalizada Accidental hypothermia due to generalized psoriasis

    O. Agudo

    2004-04-01

    Full Text Available La hipotermia accidental es una alteración de la termorregulación corporal, definida como una temperatura central igual o inferior a 35ºC. Según la intensidad se puede clasificar en ligera (35-32,2ºC, moderada (32,2-28ºC y grave (The accidental hypothermia is a disorder of corporal termoregulation, defined as a central temperature below 35ºC. According to the intensity may be classified in mild (35-32.2 ºC, moderate (32.2-28ºC and severe (below 28ºC. The most frequent causes are the exposure to cold, use of depressant drugs of central nervous system and hypoglycemia, although there are other less frequent. We present a case of moderate hypothermia due to generalized psoriasis which required admission in the Intensive Care Unit of Hospital García Orcoyen. The termoregulation, pathogenesis, pathophysiology, diagnosis and management of accidental hypothermia are reviewed.

  6. ANALYSIS OF REPORTS ABOUT 384 ELDERLY CASES OF ACCIDENTAL INJURY IN COMMUNITY%384例社区老年人意外伤害报告分析

    薛锦花

    2011-01-01

    [Objective] To understand the characteristics and causes of accidental injury of the elderly in community, in order to provide bases for preventing the occurrence of accidental injuries. [Methods] Retrospectively summarized the reports about 384 elderly cases of accidental injury in community. [Results] Homes and roads were the main sites for injury accidents; falling down and falling in accidental injuries were the main reasons for the elderly; accidental injury easily leaded to fractures of the elderly. [Conclusion] Physical characteristics of the elderly easily lead to accidental injury; improving the environment and facilities, preventing falls and preventing osteoporosis are the focuses in preventing accidental injuries; it should establish and improve accident prevention network.%[目的]了解社区老年人意外伤害的特点与原因,为防范意外伤害的发生提供依据. [方法]回顾性总结某社区卫生服务中心从2007年6月~2009年12月的384例社区老年人意外伤害报告. [结果]家中和公路是老年人发生意外伤害的主要场所;跌倒、坠落是老年人意外伤害的主要原因;老年人意外伤害易导致骨折.[结论]老年人的身体特点易导致意外伤害;改善环境设施、预防跌倒、预防骨质疏松症是防范意外伤害的重点;应建立健全意外伤害防护网络.

  7. Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

    Suzana Makpol

    2012-01-01

    Full Text Available In this study, we determined the molecular mechanism of γ-tocotrienol (GTT in preventing cellular aging by focusing on its anti-apoptotic effect in stress-induced premature senescence (SIPS model of human diploid fibroblasts (HDFs. Results obtained showed that SIPS exhibited senescent-phenotypic characteristic, increased expression of senescence-associated β-galactosidase (SA β-gal and promoted G0/G1 cell cycle arrest accompanied by shortening of telomere length with decreased telomerase activity. Both SIPS and senescent HDFs shared similar apoptotic changes such as increased Annexin V-FITC positive cells, increased cytochrome c release and increased activation of caspase-9 and caspase-3 (P<0.05. GTT treatment resulted in a significant reduction of Annexin V-FITC positive cells, inhibited cytochrome c release and decreased activation of caspase-9 and caspase-3 (P<0.05. Gene expression analysis showed that GTT treatment down regulated BAX mRNA, up-regulated BCL2A1 mRNA and decreased the ratio of Bax/Bcl-2 protein expression (P<0.05 in SIPS. These findings suggested that GTT inhibits apoptosis by modulating the upstream apoptosis cascade, causing the inhibition of cytochrome c release from the mitochondria with concomitant suppression of caspase-9 and caspase-3 activation. In conclusion, GTT delays cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins.

  8. Rede de Prevenção de Acidentes de Trabalho: uma estratégia de ensino a distância Red de Prevención de Accidentes deTrabajo: una estrategia para enseñanza a la distancia Network Prevention of Accidents at Work: a strategy for distance education

    Maria Helena Marziale

    2010-04-01

    Full Text Available Estudo quase-experimental cujo objetivo foi avaliar o treinamento interativo proposto, como estratégia de mudança no comportamento de trabalhadores para o adequado uso de luvas na administração de medicamentos endovenosos. O treinamento, estruturado no Modelo de Promoção da Saúde de Pender, foi realizado a distância pelo web site da Rede de Prevenção de Acidentes de Trabalho (REPAT, disponível em: http://repat.eerp.usp.br/estrategia/index.php e aplicado a 60 trabalhadores de enfermagem de dois hospitais estado de São Paulo. Antes do treinamento 58,3% dos trabalhadores usavam luvas para administrar medicamentos endovenosos na semana que antecedeu o treinamento e 83,3% trabalhadores informaram intenção do uso de luvas após o treinamento. Conclusão: a ferramenta interativa facilitou a aplicação da estratégia educativa no trabalho e pode auxiliar a mudança do comportamento do uso de luvas.Estudio casi-experimental cuyo objetivo fue evaluar el proyecto de formación interactiva, como una estrategia para el cambio en el comportamiento de los trabajadores, buscando el uso apropiado de guantes en la administración de drogas por vía intravenosa. La capacitación interactiva se estructuró en el Modelo de Promoción de la Salud de Pender, se llevó a cabo a través del acceso al sitio Web de la Red de Prevención de Accidentes de Trqabajo (REPAT, disponible en: http://repat.eerp.usp.br/estrategia/index.php y se aplicó en 60 trabajadores enfermería de dos hospital en el estado de Sao Paulo. En la semana antes del entrenamiento 58,3% de los trabajadores usaron guantes en la administración de drogas por vía intravenosa y, después del entrenamiento, 83,3% de los trabajadores informaron intención de usar guantes. Conclusión: la herramienta interactiva facilitado la aplicación de la estrategia educativa para la Promoción de la Salud en el Trabajo permitir que los trabajadores participen en las diferentes realidades de la vida y el

  9. Studies report: methods for the evaluation and the prevention of accidental risks (DRA 35 - report {omega} 11). Knowledge of solid fuels self-heating; Rapport d'etude: methodes pour l'evaluation et la prevention des risques accidentels (DRA 35 - rapport {omega} 11). Connaissance des phenomenes d'autoechauffement des solides combustibles

    NONE

    2005-02-15

    The aim of this document is to present a synthesis of the knowledge on risks bond to auto-heating phenomena which occur in solid fuels storage. It analyzes the role of some factors on the heating, and more specially the mass, temperature, oxygen content of the atmosphere and humidity. It presents a general methodology of risks evaluation and measures on the risks detection and prevention. (A.L.B.)

  10. Methods for the evaluation and the prevention of accidental risks (DRA-006). The BLEVE, phenomenology and simulation of thermal effects; Methodes pour l'evaluation et la prevention des risques accidentels (DRA-006). Le BLEVE, phenomenologie et modelisation des effets thermiques

    NONE

    2002-09-01

    The aim of this document is to present a synthesis on the BLEVE (Boiling Liquid Expanding Vapour Explosion) risk which could appear in the liquefied gases storage. The objective is to define a typology and a theory of the phenomena, based on passed accidents and instrumented tests, to present a synthesis of available models to describe the thermal effects generated by the BLEVE with a comparison of simulation and passed accidents, to propose some ideas for the BLEVE prevention. (A.L.B.)

  11. Accidental deaths caused by electricity in Sweden, 1975-2000.

    Lindström, Richard; Bylund, Per-Olof; Eriksson, Anders

    2006-11-01

    This study analyzes accidental fatalities caused by electricity--at work and during leisure time--to evaluate risk factors, the role of alcohol, and to identify possible preventive strategies. In Sweden, data on fatalities by electrocution from 1975 through 2000 were collected from the National Cause-of-Death Register. Additional cases were found in the archives of The Swedish National Electrical Safety Board. Suicides and deaths by lightning were excluded. Two hundred and eighty-five deaths were found, including occupational (n=132), leisure time (n=151), and unknown (n=2). Most deaths were caused by aerial power lines, and the most common place for an electrical injury was a railway area or residential property. Postmortem blood from 20% (n=47) of the tested cases was found positive for alcohol, and these persons were killed mainly during leisure time. During the study period, the overall incidence of electricity-related fatalities has decreased, in spite of increased use of electricity. This indicates that safety improvements have been successful.

  12. El accidente de trabajo. Concepto legal y jurisprudencia

    García Romero, José Daniel

    2015-01-01

    El trabajo final de grado versa sobre el concepto de accidente de trabajo que da la jurisprudencia a través de las diferentes sentencias del Tribunal Supremo en la Sala de lo Social, y de los diferentes Tribunales Superiores de Justicia. Analizaremos en profundidad que características tienen que concurrir para que sea considerado como tal, analizando los diferentes supuestos de accidente de trabajo como el accidente in itinere, en misión, etc. También hemos tratado las diferentes contingencia...

  13. The Artificial, the Accidental, the Aesthetic…

    Nicole Koltick

    2015-11-01

    Full Text Available How do we define, discuss or assess aesthetics within a contemporary philosophical framework? The indefiniteness that accompanies attempts to formalize a definition of the aesthetic is a primary focus of this paper. This lack of a definition has occupied philosophers for hundreds of years in attempts to delineate the boundaries of an elusively formless concept. This formlessness speaks to the incredibly evasive character of such a pervasive feature recognized in both natural and artificial systems, agents and artefacts. With the rapid growth of artificially intelligent systems and an astounding diversity in computational creativity, in what ways may we approach aesthetics? How is the aesthetic recognized, determined and produced? This paper seeks to critically engage issues of non-human agency, inter-object relations, and aesthetic theory in relation to computational entities and autonomous systems. The ability of these systems to operate outside of human cognitive limitations including thought patterns and constructions which may preclude alternative aesthetic outcomes, afford them in some ways limitless potential in relation to aesthetics. The designation of the accidental or provisional is utilized as an alternative approach to the production and assessment of aesthetic occurrences of the non-human.

  14. Presentismo: potencialidad en accidentes de salud

    Grettchen Flores-Sandí

    2006-03-01

    Full Text Available El concepto de salud ha sobrepasado el entorno propiamente sanitario y cada vez más, tiene otras implicaciones sociales, la institución de salud es hoy en día una actividad compleja donde no solamente se gestiona la prevención y tratamiento de las enfermedades de los usuarios sino al recurso humano encargado de su atención. Asimismo en la actualidad se reconoce la importancia del recurso humano para la organización y surge el concepto de "presentismo", referido a aquellos trabajadores que sufren enfermedades que los obligarían a ausentarse del trabajo pero que se presentan a trabajar sin cumplir eficazmente sus funciones. Al respecto y en relación con el presentismo, se debe tomar en cuenta que los efectos adversos o accidentes durante la atención de servicios de salud se encuentran asociados a factores fisiológicos, psicológicos y ambientales e implican desde el punto de vista administrativo, una falla en la productividad, que afecta tanto al usuario del servicio como al trabajador. Se debe considerar que este grupo profesional se ubica entre los grupos de riesgo del presentismo y que con el fin de administrar y reducir el presentismo se requieren estrategias preventivas por parte de la gerencia de salud.

  15. Quick management of accidental tritium exposure cases.

    Singh, Vishwanath P; Badiger, N M; Managanvi, S S; Bhat, H R

    2012-07-01

    Removal half-life (RHL) of tritium is one of the best means for optimising medical treatment, reduction of committed effective dose (CED) and quick/easy handling of a large group of workers for medical treatment reference. The removal of tritium from the body depends on age, temperature, relative humidity and daily rainfall; so tritium removal rate, its follow-up and proper data analysis and recording are the best techniques for management of accidental acute tritium exposed cases. The decision of referring for medical treatment or medical intervention (MI) would be based on workers' tritium RHL history taken from their bodies at the facilities. The workers with tritium intake up to 1 ALI shall not be considered for medical treatment as it is a derived limit of annual total effective dose. The short-term MI may be considered for tritium intake of 1-10 ALI; however, if the results show intake ≥100 ALI, extended strong medical/therapeutic intervention may be recommended based on the severity of exposure for maximum CED reduction requirements and annual total effective dose limit. The methodology is very useful for pressurized heavy water reactors (PHWRs) which are mainly operated by Canada and India and future fusion reactor technologies. Proper management will optimise the cases for medical treatment and enhance public acceptance of nuclear fission and fusion reactor technologies.

  16. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats.

    Singh, Brijesh Kumar; Tripathi, Madhulika; Chaudhari, Bhushan P; Pandey, Pramod K; Kakkar, Poonam

    2012-01-01

    Nimesulide, an anti-inflammatory and analgesic drug, is reported to cause severe hepatotoxicity. In this study, molecular mechanisms involved in deranged oxidant-antioxidant homeostasis and mitochondrial dysfunction during nimesulide-induced hepatotoxicity and its attenuation by plant derived terpenes, camphene and geraniol has been explored in male Sprague-Dawley rats. Hepatotoxicity due to nimesulide (80 mg/kg BW) was evident from elevated SGPT, SGOT, bilirubin and histo-pathological changes. Antioxidants and key redox enzymes (iNOS, mtNOS, Cu/Zn-SOD, Mn-SOD, GPx and GR) were altered significantly as assessed by their mRNA expression, Immunoblot analysis and enzyme activities. Redox imbalance along with oxidative stress was evident from decreased NAD(P)H and GSH (56% and 74% respectively; Pterpenes against nimesulide toxicity. Therefore CG, a combination of natural terpenes prevented nimesulide induced cellular damage and ensuing hepatotoxicity.

  17. Understanding drug-related mortality in released prisoners: a review of national coronial records

    Andrews Jessica Y

    2012-04-01

    Full Text Available Abstract Background The prisoner population is characterised by a high burden of disease and social disadvantage, and ex-prisoners are at increased risk of death following release. Much of the excess mortality can be attributed to an increased risk of unnatural death, particularly from drug overdose; however, relatively few studies have investigated the circumstances surrounding drug-related deaths among released prisoners. This study aimed to explore and compare the circumstances of death for those who died from accidental drug-related causes to those who died from all other reportable causes. Methods A nationwide search of the Australian National Coroners Information System (NCIS was conducted to identify reportable deaths among ex-prisoners from 2000 to 2007. Using a structured coding form, NCIS records for these cases were interrogated to explore causes and circumstances of death. Results Coronial records for 388 deceased ex-prisoners were identified. Almost half of these deaths were a result of accidental drug-related causes (45%. The majority of accidental drug-related deaths occurred in a home environment, and poly-substance use at or around the time of death was common, recorded in 72% of drug-related deaths. Ex-prisoners who died of accidental drug-related causes were on average younger and less likely to be Indigenous, born in Australia, married, or living alone at or around the time of death, compared with those who died from all other reportable causes. Evidence of mental illness or self-harm was less common among accidental drug-related deaths, whereas evidence of previous drug overdose, injecting drug use, history of heroin use and history of drug withdrawal in the previous six months were more common. Conclusions Drug-related deaths are common among ex-prisoners and often occur in a home (vs. public setting. They are often associated with use of multiple substances at or around the time of death, risky drug-use patterns, and even

  18. Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

    Nic An Ultaigh, Sinead

    2011-02-23

    Abstract Introduction The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. Methods RA synovial tissue biopsies, obtained under direct visualization at arthroscopy, were established as synovial explant cultures ex vivo or snap frozen for immunohistology. Mononuclear cell cultures were isolated from peripheral blood and synovial fluid of RA patients. Cultures were incubated with the TLR1\\/2 ligand, Pam3CSK4 (200 ng, 1 and 10 μg\\/ml), an anti-TLR2 antibody (OPN301, 1 μg\\/ml) or an immunoglobulin G (IgG) (1 μg\\/ml) matched control. The comparative effect of OPN301 and adalimumab (anti-tumour necrosis factor alpha) on spontaneous release of proinflammatory cytokines from RA synovial explants was determined using quantitative cytokine MSD multiplex assays or ELISA. OPN301 penetration into RA synovial tissue explants cultures was assessed by immunohistology. Results Pam3CSK4 significantly upregulated interleukin (IL)-6 and IL-8 in RA peripheral blood mononuclear cells (PBMCs), RA synovial fluid mononuclear cells (SFMCs) and RA synovial explant cultures (P < 0.05). OPN301 significantly decreased Pam3CSK4-induced cytokine production of tumour necrosis factor alpha (TNF-α), IL-1β, IL-6, interferon (IFN)-γ and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures (all P < 0.05). OPN301 penetration of RA synovial tissue cultures was detected in the lining layer and perivascular regions. OPN301 significantly decreased spontaneous cytokine production of TNF-α, IL-1β, IFN-γ and IL-8 from RA synovial tissue explant cultures (all P < 0.05). Importantly, the inhibitory effect of OPN on spontaneous cytokine secretion was comparable to inhibition by anti-TNFα monoclonal antibody adalimumab. Conclusions These findings further support targeting TLR2 as a potential therapeutic agent for the treatment of RA.

  19. Epidemiological evaluations of the efficacy of slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and animals.

    Wei, Jiao; Cheng, Fu; Qun, Qu; Nurbek; Xu, Shi-Dong; Sun, Li-Feng; Han, Xin-Kui; Muhan; Han, Ling-Ling; Irixiati; Jie, Peng; Zhang, Ke-Jiu; Islayin; Chai, Jun-jie

    2005-12-01

    To assess the epidemiological efficacy of type SRP III slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and livestock, praziquantel-medicated bars were implanted subcutaneously in over 90% of dogs in villages in north Xinjiang, China, where cystic echinococcosis is highly endemic. After implantation, infection rate of Echinococcus granulosus in dogs, specific antibodies in children and prevalence of echinococcosis in one-year-old lambs were observed for 3 years. Coproantigen of E. granulosus was positive in 41.2% of the dogs at the start of experiment. In the second and third year after medicated-bar implantation, coproantigen was undetectable in any dogs examined, while 3.0% of dogs were positive at the end of the fourth year. The antibody positive rate in 7-year-old pupils, that was 41.2% before the experiment, declined gradually and it was 5.4% in the fourth year, while children in the non-intervention control area showed 30.6% seropositivity. The prevalence of hydatid disease in children aged 7-16 years also declined significantly. The prevalence of hydatidosis in lambs one year of age was 44.8% in the first year, dropping to 10.7% in the fourth year, while in the non-intervention control area the level of infection was 46.4%. These results demonstrated not only that the slow released praziquantel-medicated bars efficiently blocked reinfection in dogs at least for 2 years, but also the measure was effective in preventing transmission of cystic echinococcosis to both man and livestock.

  20. Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion.

    Sabrina Jarazo Dietrich

    Full Text Available Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO is a model of chronic inflammation whose main histopathological features it shares with human orchitis. In EAO an increased number of macrophages infiltrate the interstitium concomitantly with progressive germ cell degeneration and impaired steroidogenesis. Up-regulation of nitric oxide (NO-NO synthase (NOS system occurs, macrophages being the main producers of NO.The aim of our study was to evaluate the role of NO-NOS system in orchitis development and determine the involvement of NO released by testicular macrophages on germ cell apoptosis and testosterone secretion.EAO was induced in rats by immunization with testicular homogenate and adjuvants (E group and a group of untreated normal rats (N was also studied. Blockage of NOS by i.p. injection of E rats with a competitive inhibitor of NOS, L-NAME (8mg/kg, significantly reduced the incidence and severity of orchitis and lowered testicular nitrite content. L-NAME reduced germ cell apoptosis and restored intratesticular testosterone levels, without variations in serum LH. Co-culture of N testicular fragments with testicular macrophages obtained from EAO rats significantly increased germ cell apoptosis and testosterone secretion, whereas addition of L-NAME lowered both effects and reduced nitrite content. Incubation of testicular fragments from N rats with a NO donor DETA-NOnoate (DETA-NO induced germ cell apoptosis through external and internal apoptotic pathways, an effect prevented by N-acetyl-L-cysteine (NAC. DETA-NO inhibited testosterone released from Leydig cells, whereas NAC (from 2.5 to 15 mM did not prevent this effect.We demonstrated that NO-NOS system is involved in the impairment of testicular function in orchitis. NO secreted mainly by testicular macrophages could promote oxidative stress

  1. Gastrin-releasing peptide facilitates glutamatergic transmission in the hippocampus and effectively prevents vascular dementia induced cognitive and synaptic plasticity deficits.

    Yang, Jiajia; Yao, Yang; Wang, Ling; Yang, Chunxiao; Wang, Faqi; Guo, Jie; Wang, Zhiyun; Yang, Zhuo; Ming, Dong

    2017-01-01

    Neuronal gastrin-releasing peptide (GRP) has been proved to be an important neuromodulator in the brain and involved in a variety of neurological diseases. Whether GRP could attenuate cognition impairment induced by vascular dementia (VD) in rats, and the mechanism of synaptic plasticity and GRP's action on synaptic efficiency are still poorly understood. In this study, we first investigated the effects of GRP on glutamatergic transmission with patch-clamp recording. We found that acute application of GRP enhanced the excitatory synaptic transmission in hippocampal CA1 neurons via GRPR in a presynaptic mechanism. Secondly, we examined whether exogenous GRP or its analogue neuromedin B (NMB) could prevent VD-induced cognitive deficits and the mechanism of synaptic plasticity. By using Morris water maze, long-term potentiation (LTP) recording, western blot assay and immunofluorescent staining, we verified for the first time that GRP or NMB substantially improved the spatial learning and memory abilities in VD rats, restored the impaired synaptic plasticity and was able to elevate the expression of synaptic proteins, synaptophysin (SYP) and CaMKII, which play pivotal roles in synaptic plasticity. These results suggest that the facilitatory effects of GRP on glutamate release may contribute to its long-term action on synaptic efficacy which is essential in cognitive function. Our findings present a new entry point for a better understanding of physiological function of GRP and raise the possibility that GRPR agonists might ameliorate cognitive deficits associated with neurological diseases.

  2. Epidemiology of Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation.

    McClure, R J; Davis, P M; Meadow, S R; Sibert, J R

    1996-07-01

    A two year prospective study was performed to determine the epidemiology of Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation in the UK and the Republic of Ireland. Cases were notified to the British Paediatric Association Surveillance Unit from September 1992 to August 1994 if a formal case conference had been held for the first time during that period to discuss any of the above conditions. A total of 128 cases were identified: 55 suffered Munchausen syndrome by proxy alone, 15 poisoning, and 15 suffocation; 43 suffered more than one type of abuse. The majority of children were aged under 5 years, the median age being 20 months. On 85% of occasions the perpetrator was the child's mother. In 42% of families with more than one child, a sibling had previously suffered some form of abuse. Eighty five per cent of notifying paediatricians considered the probability of their diagnosis as virtually certain before a case conference was convened. The commonest drugs used to poison were anticonvulsants; opiates were the second commonest. Sixty eight children suffered severe illness of whom eight died. The combined annual incidence of these conditions in children aged under 16 years is at least 0.5/100,000, and for children aged under 1, at least 2.8/100,000.

  3. Development of management tools for accidental radiological contamination of the French coastal areas - Development of management tools for accidental radiological contamination in the French marine coastal areas

    Duffa, C.; Charmasson, S. [IRSN/PRP-ENV/SESURE/LERCM - Antenne de Radioecologie Marine, Centre Ifremer, Zone portuaire de Bregaillon, 13507 La Seyne sur Mer (France); Bailly du Bois, P.; Fievet, B. [IRSN/PRP-ENV/SERIS/LRC (France); Couvez, C.; Renaud, P. [IRSN/PRP-ENV/SESURE/DIR (France); Didier, D. [IRSN/PRP-CRI/SESUC/BMTA (France)

    2014-07-01

    The Fukushima nuclear accident led to the most important accidental release of artificial radionuclides into the sea. This accident has underlined the importance of being able to adequately reproduce the fate of radioactive releases and to estimate their consequences for the marine environment. For its Crisis Centre, the French Institute for Radioprotection and Nuclear Safety (IRSN) has operational tools, in order to help experts and decision makers in case of any atmospheric accidental release and terrestrial environment contamination. The on-going project aims to develop tools to manage any marine contamination of the French coastal areas. We should be able to evaluate and anticipate the marine post-accidental situation: contaminated areas localization and contamination levels, and possible consequences. Many sites has be considered as potential source terms into the sea: the Coastal Nuclear Power Plants, the La Hague reprocessing Plant, the Brest and Toulon Military Harbours as home-ports of nuclear powered vessels, and different river mouths (Rhone River, Gironde, Loire, Seine) that could be contaminated by upstream accidental release. To achieve this goal, two complementary approaches are developed: Marine sheets and a dedicated modelling tool (STERNE). - Marine sheets aim to summarize marine environment characteristics for the different sites, identify potential stakes for human protection such as aquaculture areas, beaches, or industrial water intakes, and ecological stakes. Whenever possible, a local climatology (main currents depending on meteorological or tide conditions) that could be a support to first environmental measurement strategy is proposed. A list of available local contacts for any operational management is also provided. - The modelling tool, STERNE (Simulation du Transport et du transfert d'Elements Radioactifs dans l'environNEment marin), must predict radionuclide dispersion and contamination of water, marine species and sediments

  4. The 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H MacG; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

    2014-10-01

    not risk factors for accidental awareness: ASA physical status; race; and use or omission of nitrous oxide. We recommend that an anaesthetic checklist, to be an integral part of the World Health Organization Safer Surgery checklist, is introduced as an aid to preventing accidental awareness. This paper is a shortened version describing the main findings from 5th National Audit Project - the full report can be found at http://www.nationalauditprojects.org.uk/NAP5_home#pt.

  5. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release

    Zhang YueMei

    2005-02-01

    absence of 17β-estradiol or Δ8, 17β-estradiol (10 nM-10 μM resulted in the prevention of cell death and was associated with a significant dose-dependent decrease in caspase-3 protein levels, with Δ8, 17β-E2 being more potent than 17β-E2. Protein levels of Fas receptor remained unchanged in the presence of glutamate. In contrast, treatment with glutamate induced, in a time-dependent manner, the release of cytochrome c into the cytosol. Cytosolic cytochrome c increased as early as 1.5 h after glutamate treatment and these levels were 5 fold higher after 6 h, compared to levels in the untreated cells. Concomitant with these changes, the levels of cytochrome c in mitochondria decreased significantly. Both 17β-E2 and Δ8, 17β-E2 reduced the release of cytochrome c from mitochondria into the cytosol and this decrease in cytosolic cytochrome c was associated with inhibition of glutamate-induced cell death. Conclusion In the primary cortical cells, glutamate-induced apoptosis is accompanied by up-regulation of caspase-3 and its activity is blocked by caspase protease inhibitors. These effects of glutamate on caspase-3 appear to be independent of changes in Fas receptor, but are associated with the rapid release of mitochondrial cytochrome c, which precedes changes in caspase-3 protein levels leading to apoptotic cell death. This process was differentially inhibited by estrogens with the novel equine estrogen Δ8, 17β-E2 being more potent than 17β-E2. To our knowledge, this is the first study to demonstrate that equine estrogens can prevent glutamate-induced translocation of cytochrome c from mitochondria to cytosol in rat primary cortical cells.

  6. Non-accidental collision followed by dental trauma: associated factors.

    Ramos-Jorge, Maria Letícia; Tataounoff, Juliana; Corrêa-Faria, Patrícia; Alcântara, Carlos Eduardo Pinto; Ramos-Jorge, Joana; Marques, Leandro Silva

    2011-12-01

    The aim of the present cross-sectional survey was to assess factors associated with non-accidental collision followed by dental trauma among adolescents in the city of Diamantina, Brazil. A total of 387 students from 12 to 15 years of age (mean = 14 SD = 0.9) were randomly selected. The study was carried out in two stages. Firstly, data were collected through dental examinations of permanent incisors. Secondly, a thorough interview was held with 85 adolescents who exhibited dental trauma in the dental examinations. The interview consisted of a detailed description of the incident and physical environment in which it occurred. Descriptive analysis and the chi-square test (P 3 mm (P = 0.007) and inadequate lip coverage (P = 0.013). Analysis of the event revealed that 22.3% of the cases of dental trauma occurred because of non-accidental collision. Non-accidental collision followed by injury occurred mainly at school (P concrete, tiled or ceramic floor (P = 0.001). No statistically significant associations were found between non-accidental collision and gender, age or mother's schooling. It was concluded that the non-accidental collisions happened especially at school and in indoor environments with a concrete, tiled or ceramic floor.

  7. Ingestion Pathway Consequences of a Major Release from SRTC

    Blanchard, A.

    1999-06-08

    The food ingestion consequences due to radioactive particulates of an accidental release, scenario 1-RD-3, are evaluated for Savannah River Technology Center. The sizes of land areas requiring the protective action of food interdiction are calculated. The consequences of the particulate portion of the release are evaluated with the HOTSPOT model and an EXCEL spreadsheet for particulates.

  8. Avancée dans la prévention des « chutes de plain-pied » au travail Progress in the prevention of occupational “falls on the same level”. Proposed operational definition of a new category: “Motion perturbation accidents (MPAs” Avances en la prevención de « caídas al mismo nivel » en el trabajo. Propuesta de la definición operacional de una nueva categoría : « los Accidentes con Perturbación del Movimiento (APM »

    Sylvie Leclercq

    2010-11-01

    causes injury due to its properties and subsequently called a “circumstantial hazard”. Finally, the reasoning behind the MPA classification is explained. In particular, it appears that prevention that focuses on the immediate causes of the injury is difficult, even impossible, in MPA cases, essentially because of requirements inherent in the work and the constraints on the enterprise to implement this prevention. Prevention implemented at the source of the risk therefore seems to be the only feasible solution. From commonplace accidents, MPAs reveal dysfunctions within the production system.Las caídas al mismo nivel continúan siendo un accidente laboral frecuente y grave. La terminología usada para describir estos accidentes es variada, relativamente imprecisa y no integra la diversidad de accidentes encontrados bajo diferentes apelaciones. En un inicio, el interés de considerar una categoría de accidentes con una perturbación del movimiento (APM es puesto en evidencia a partir de diversos extractos de relatos de accidentes laborales. A continuación, un modelo es propuesto para los APM, mostrando que en estos accidentes la lesión resulta a menudo de una asociación fortuita entre la energía del movimiento perturbado de la víctima y un elemento material, convertido en agresor por sus propiedades y subsecuentemente llamado un « peligro circunstancial ». Finalmente, el razonamiento detrás de la clasificación de estos accidentes es explicado. En particular, parece ser que la prevención enfocada en las causas inmediatas de la lesión es difícil, incluso imposible en los casos de APM, debido esencialmente a las exigencias inherentes al trabajo y a las dificultades que pesarían en la empresa para la implantación de esta prevención. La prevención realizada en la fuente del riesgo tiende entonces a convertirse en la única posibilidad. Así pues, los APM pasan de ser accidentes banales a ser reveladores de las disfunciones dentro de un sistema de

  9. Nitric Oxide Releasing Nanoparticles prevent Propionibacterium acnes induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response

    Qin, Min; Landriscina, Angelo; Rosen, Jamie; Wei, Gabrielle; Kao, Stephanie; Olcott, William; Agak, George W.; Paz, Karin Blecher; Bonventre, Josephine; Clendaniel, Alicea; Harper, Stacey; Adler, Brandon; Krausz, Aimee; Friedman, Joel; Nosanchuk, Joshua; Kim, Jenny; Friedman, Adam J

    2015-01-01

    Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. Therefore, therapeutics targeting both the stimulus and the cascade would be ideal. Nitric oxide (NO), a potent biological messenger, has documented broad-spectrum antimicrobial and immunomodulatory properties. To harness these characteristics to target acne, we utilized an established nanotechnology capable of generating/releasing nitric oxide over time (NO-np). P. acnes was found to be highly sensitive to all concentrations of NO-np tested, though human keratinocyte, monocyte, and embryonic zebra fish assays revealed no cytotoxicity. NO-np significantly suppressed IL-1β, TNF-α, IL-8 and IL-6 from human monocytes and IL-8 and IL-6 from human keratinocytes respectively. Importantly, silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of IL-1 β secretion from monocytes, and neither TNF-α, nor IL-6 secretion nor inhibition by NO-np was found to be dependent on this pathway. The observed mechanism by which NO-np impacts IL-1β secretion was through inhibition of caspase-1 and IL-1β gene expression. Together, these data suggest that NO-np can effectively prevent P. acnes induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response. PMID:26172313

  10. Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response.

    Qin, Min; Landriscina, Angelo; Rosen, Jamie M; Wei, Gabrielle; Kao, Stephanie; Olcott, William; Agak, George W; Paz, Karin B; Bonventre, Josephine; Clendaniel, Alicea; Harper, Stacey; Adler, Brandon L; Krausz, Aimee E; Friedman, Joel M; Nosanchuk, Joshua D; Kim, Jenny; Friedman, Adam J

    2015-11-01

    Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR, nucleotide oligomerization domain-like receptor) inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. Therefore, therapeutics targeting both the stimulus and the cascade would be ideal. Nitric oxide (NO), a potent biological messenger, has documented broad-spectrum antimicrobial and immunomodulatory properties. To harness these characteristics to target acne, we used an established nanotechnology capable of generating/releasing NO over time (NO-np). P. acnes was found to be highly sensitive to all concentrations of NO-np tested, although human keratinocyte, monocyte, and embryonic zebra fish assays revealed no cytotoxicity. NO-np significantly suppressed IL-1β, tumor necrosis factor-α (TNF-α), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively. Importantly, silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of IL-1 β secretion from monocytes, and neither TNF-α nor IL-6 secretion, nor inhibition by NO-np was found to be dependent on this pathway. The observed mechanism by which NO-np impacts IL-1β secretion was through inhibition of caspase-1 and IL-1β gene expression. Together, these data suggest that NO-np can effectively prevent P. acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response.

  11. Correcting for accidental correlations in saturated avalanche photodiodes

    Grieve, James A; Tang, Zhongkan; Ling, Alexander

    2015-01-01

    In this paper we present a high-level numerical model for estimating rates of accidental correlations between a pair of passively quenched Geiger mode avalanche photodiodes operating in the saturated regime. By considering the recovery time of both the diodes and the detection circuit we introduce the concept of an "effective duty cycle" and show that it may be estimated by numeric simulation. The impact of effective duty cycle on the observed accidental rate is examined and we demonstrate that the updated model leads to an improved correction factor in actual experiments. This will improve the signal-to-noise ratio in applications depending on correlation measurements.

  12. Perfil del trauma maxilofacial en accidentes de bicicleta

    Guadalupe Asunción Ramírez Roa; María Guadalupe Suárez-Moreno; Florentino Puerto-Álvarez; Heber Félix Quiroga-Vía; Jesús Arenas-Osuna; Bertha Vivanco-Cedeño

    2005-01-01

    Objetivo: conocer el perfil traumatológico maxilofacial, concomitante y manejo, de las personas que sufrieron accidentes de bicicleta. Se identificaron variables como edad, sexo, mecanismo, lugar, mes, patrones de lesiones, sintomatología, lapso de atención, turno, especialidad y tratamientos. Diseño: exploratorio, descriptivo, analítico, retrospectivo. Material y métodos: se censaron todos los pacientes con lesiones maxilofaciales por accidentes de bicicleta, de las notas médicas del Servici...

  13. ACCIDENTAL DEATHS DUE TO ELECTROCUTION DURING AMATEUR ELECTRO - FISHING

    Ajay

    2013-11-01

    Full Text Available ABSTRACT: Electro - fishing (passing electricity through water to catch fish requires sophisticated equipment. While this method is commonly employed b y scientists for survey and fisheries management, a crude and illegal form electro - fishing is employed in Kerala for catching fish from water bodies. This can result in accidental electrocution and even fatalities. Even though they are rare, forensic patho logists in Kerala do come across such deaths from time to time. 8 cases of accidental death which occurred during electro - fishing are discussed here.

  14. Accidentes laborales, medicamentos y hábitos de salud

    Esteban Martín, María Ángeles

    2015-01-01

    El presente estudio está dirigido a analizar la posible asociación con el accidente de trabajo del tipo y cantidad de medicamentos que consumen los trabajadores de forma crónica y/o aguda antes de acudir a nuestra consulta, de las enfermedades crónicas y/o agudas que padecen y de otros hábitos de consumo (alcohol y drogas). La salud laboral es un problema prioritario. El objetivo será promover la salud de los trabajadores y tratar de disminuir la incidencia de accidentes laborales. E...

  15. 提升陪护者安全意识对预防住院患儿意外伤害发生的效果观察%Observation on Effect of Improving the Safety Awareness of Caregivers on Preventing the Occurrence of Accidental Injury of Hospitalized Children

    陈娟; 刘玮

    2016-01-01

    目的:评估住院患儿陪护者对患儿安全问题的认识程度,找出其认识薄弱或认识不到位的环节,对其进行有针对性的安全知识教育,改变其行为,降低住院患儿意外伤害发生率。方法将该科2015年11月-2016年6月住院的556名高危患儿随机分为2组,制定陪护人员安全知识评估量表,根据量表对高危患儿的陪护人员进行评估,评估后对照组按常规工作流程进行安全宣教,观察组在此基础上,找到陪护人安全认识不足的环节,向陪护人对此环节强化安全知识宣教。结果对照组意外伤害发生率为5.7%,观察者意外伤害发生率为1.4%。结论对安全意识淡薄或缺乏的住院患儿陪护者进行有针对性的安全知识宣教,提高其对小儿安全问题的认识,提升安全措施的依从性,可以显著降低住院患儿意外伤害的发生率。%Objective To evaluate the hospitalized children caregiver's awareness degree of children safety issues, find out the links of weak awareness or insufficient awareness, and carry out the targeted safety knowledge education for them, and change their behaviors thus reducing the incidence rate of accidental injury of hospitalized children. Methods 556 cases of high-risk children hospitalized in our department in our hospital from November 2015 to June 2016 were randomly divided into two groups, and the safety knowledge assessment scale of caregivers was made, and the caregivers of high-risk children were assessed according to the scale, after assessment, the control group adopted the safety education according to the rou-tine workflow, and the observation group found out the links of insufficient safety awareness and carry out the targeted safe-ty knowledge education for caregivers on the basis of the control group. Results The incidence rate of accidental injury was 5.7%in the control group and 1.4% in the observation group. Conclusion The targeted safety

  16. Accidental contamination of a German town's drinking water with sodium hydroxide.

    Lendowski, Luba; Färber, Harald; Holy, Andreas; Darius, Anke; Ehrich, Bernd; Wippermann, Christine; Küfner, Bernd; Exner, Martin

    2015-05-01

    Case report of a very serious drinking water incident putting up to 50,000 inhabitants of a town near Bonn in North Rhine-Westphalia, Germany at risk. A concentrated solution of highly alkaline water by sodium hydroxide was accidentally washed into the town's drinking water at a pumping station and increased the pH-value of the water to 12. Residents who came into contact with the contaminated water immediately had a toxic reaction. The incident was detected by complaints from customers and after that was stopped within several hours. The pipes were flushed and the customers were warned not to use the water till the all clear. After this immediate management there was an investigation and the cause of the incident was detected as an accidental release of accumulated sodium hydroxide (NaOH) solution. The lack of a network alarm system and the automatic cut-off mechanisms as deficiencies in the design of the station were rectified by the water company immediately after the incident.

  17. The Accidental Transgressor: Morally-Relevant Theory of Mind

    Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah; Woodward, Amanda

    2011-01-01

    To test young children's false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N=162) at 3.5, 5.5, and 7.5 years of age were administered three tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an "accidental transgressor" task, which measured a…

  18. An accidental sect: how war made belief in Sierra Leone

    Richards, P.

    2006-01-01

    Idealists consider beliefs cause wars. Realists consider wars cause beliefs. The war in Sierra Leone offers some scope to test between these two views. The main rebel faction, the Revolutionary United Front (RUF) was, sociologically speaking, an accidental sect. It lost its original ideologues at an

  19. Quality control for handling of accidental blood exposures.

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  20. The accidental overexposures; Les surexpositions accidentelles

    Nenot, J.C.

    1993-03-01

    The radioisotope or ionizing radiation medical or industrial use may generate accidents where human beings are exposed to very high doses. The accident frequency is increasing quickly because of the industrial source use development. The accidents don`t catch only the plant or hospital staffs but also public people. The serious accidents result from conception errors, bad installation maintenance, lack or not enough staff training, transgression of safety processes. The accidents happen in not very specialized firms. Those resulting from energy production reactors are very seldom except for Chernobyl or military submarines. In the medical or hospital installations, accidents may affect the staffs or the patients. Most of the accidents could have been avoided by the simple respect of the simple surety duties. The follow up and analysis of serious accidents can bring an effective collaboration to the prevention. 78 refs., 3 annexes., 14 tabs., 17 figs.

  1. Responsabilidad del empleador por accidentes de trabajo y enfermedades profesionales

    Cristina Mangarelli

    2014-01-01

    Full Text Available Introducción. 1. Responsabilidad del “empleador” por accidentes de trabajo y enfermedades profesionales. Noción. 2. La indemnización “tarifada”. Fundamento de su procedencia 3. Responsabilidad del empleador por accidentes de trabajo o enfermedades profesionales en la ley uruguaya (ley Nº 16.074. 4. La “ampliación” de la responsabilidad del empleador por el derecho común en el derecho uruguayo (artículo 7 ley Nº 16.074. 5. Requisitos para la ampliación de la responsabilidad patronal: culpa grave en el incumplimientode normas de seguridad y prevención. 6. La culpa grave. Concepto. 7. El modelo del hombre a tener en cuenta en la “culpa grave” no es el del buen padre de familia. 8. El grado de la culpa no puede ser medido por el resultado del accidente. 9. Se aplican las eximentes de la responsabilidad civil. 10. Distintos ámbitos de la responsabilidad patronal por accidentes de trabajo o enfermedades profesionales: A ante la víctima o los derecho-habientes; B ante el Banco de Seguros del Estado; C ante el Ministerio de Trabajo ySeguridad Social. 11. Recupero del BSE en caso de culpa grave en el incumplimiento de normas de seguridad y prevención. Requisitos 12. Responsabilidad del empleador en caso de accidente de trabajo o enfermedad profesional sufrido por un adolescente. Conclusiones.

  2. Reducing the loss of vaccines from accidental freezing in the cold chain: the experience of continuous temperature monitoring in Tunisia.

    Lloyd, John; Lydon, Patrick; Ouhichi, Ramzi; Zaffran, Michel

    2015-02-11

    Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead of equipping the program with medical refrigerators designed specifically for storing vaccines and temperature sensitive pharmaceuticals. Against this backdrop, this paper presents the findings of a demonstration project conducted in Tunisia in 2012 that tested the impact of introducing several freeze prevention solutions to mitigate the risk of accidental freezing of vaccines. The main finding is that, despite the continued use of underperforming domestic refrigerators, continuous temperature monitoring using new technologies combined with other technological interventions significantly reduced the prevalence of accidental exposure to freezing temperatures. These improvements were noticed for cold chain storage at regional, district and health center levels, and during the transport legs that were part of the demonstration conducted in the regions of Kasserine in the South-Eastern part of Tunisia. Subsequent to introducing these freeze prevention solutions, the incidence of freeze alarms was reduced and the percent of time the temperatures dropped below the 2 °C recommended threshold. The incidence of freeze alarms at health center level was reduced by 40%. Lastly, the solutions implemented reduced risk of freezing during transport from 13.8% to 1.7%. Although the solution implemented is not optimal in the longer term because domestic refrigerators are used extensively in district stores and health centers, the risk of accidental freezing is significantly reduced by introducing the practice of continuous temperature monitoring as a standard. The management of the cold chain equipment was strengthened as a result which helps protect the potency of

  3. Accidentes de tránsito fatales en Costa Rica en el 2007

    Maikel Vargas Sanabria

    2008-09-01

    Full Text Available Los accidentes de tránsito en Costa Rica contribuyen significativamente con la tercera causa de muerte en el país en los últimos años: las causas externas, por ello resulta importante conocer el panorama más reciente de las fatalidades causadas por estos eventos. En el presente trabajo se analizarán desde el punto de vista médico legal los accidentes de tránsito fatales, cuyas víctimas fallecieron en el año 2007. Para ello se revisaron todas las autopsias efectuadas (un total de 3003 en el Departamento de Medicina Legal de Costa Rica para ese año. Se obtuvo que una cuarta parte de las mismas se originaron en accidentes de tránsito, lo cual generó una tasa de mortalidad de 16,58 por 100000 habitantes, considerada alta a nivel mundial. El perfil predominante de las víctimas fue: ser de género masculino, en edad económicamente productiva, con accidentes fatales de predominio en la noche, los fines de semana, en las provincias costeras, con fallecimiento en el sitio del hecho por trauma cráneo cervical en ocupantes de automotores o peatones, de los cuales un porcentaje significativo estaba bajo los efectos del alcohol y muy pocos bajo los efectos de otras drogas de abuso. Se insiste en la prevención como la herramienta fundamental para evitarlos.Traffic accidents in Costa Rica have been a contributing cause of death (the third cause of death over the last years; that ’s why its is a mayor issue to know the panorama of the latest fatalities caused by this events. In this article, it will be analyzed from the legal medicine point of view, the fatal transit accidents during the year 2007. For these reason all autopsies (a total of 3003 occurred during that year which were made by the Departamento de Medicina Legal de Costa Rica were reviewed. From these revision, it was obtained that one forth of these autopsies were transit accidents, which means that the mortality rate was 16,58 per 100000 habitants, that is consider high over the

  4. Evaluation of patients who admitted to hospital due to accidentally falling objects on them

    Yahya Turan

    2015-03-01

    Full Text Available Objective: Accidents at home, office, or outdoor environment are one of the leading cause of injury and death, especially in children. The aim of this study is the evaluation of patients admitted to our hospital due to the falling on an object accidentally. Methods: This study retrospectively assessed the medical records of 135 patients who were accidentally injured by a heavy object that fell on them between 2012 and 2014. Age, sex, object type as the cause of incident, site and time of the incident, and the death cause were analyzed. Results: Eighty-two (60.7% patients were male and 53 (39.3% were female and the mean age of the study population was 18.8 (0-79 years. The patients were most commonly from the pediatric age group (0-18 years old (n=78, 57.8%. When falling objects types are evaluated respectively dropping on a television with 18.5% (25 patients, stone(s with 15.6% (21 patients and objects made of iron with 11.1% (15 patients shares first three places. The most common sites of the incident were home (n=85, 62.9%. The incidents most commonly occurred in summer months (n=93, 68.9%. Conclusion: In this study obtained data should be contributed to accident prevention programs especially for children.

  5. El accidente de trabajo "in itinere" = Working in the accident "itinere"

    Pinillas Carro, Pedro

    2015-01-01

    El trabajo aqu?? presentado aborda el estudio de los accidentes de trabajo, regulado al art??culo 115 Ley General de Seguridad Social, y m??s concretamente el accidente in itinere, claro est??, sin olvidar tampoco el accidente en misi??n. En la primera parte del trabajo, y una vez desarrollado el concepto de accidente de trabajo, el presente trabajo se centra en el estudio pormenorizado del accidente in itinere y sus requisitos (teleol??gico, topogr??fico, cronol??gico y mec??nico). Por otro ...

  6. Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death.

    Almeida, Ana S; Soares, Nuno L; Vieira, Melissa; Gramsbergen, Jan Bert; Vieira, Helena L A

    2016-01-01

    Cerebral ischemia and neurodegenerative diseases lead to impairment or death of neurons in the central nervous system. Stem cell based therapies are promising strategies currently under investigation. Carbon monoxide (CO) is an endogenous product of heme degradation by heme oxygenase (HO) activity. Administration of CO at low concentrations produces several beneficial effects in distinct tissues, namely anti-apoptotic and anti-inflammatory. Herein the CO role on modulation of neuronal differentiation was assessed. Three different models with increasing complexity were used: human neuroblastoma SH-S5Y5 cell line, human teratocarcinoma NT2 cell line and organotypic hippocampal slice cultures (OHSC). Cell lines were differentiated into post-mitotic neurons by treatment with retinoic acid (RA) supplemented with CO-releasing molecule A1 (CORM-A1). CORM-A1 positively modulated neuronal differentiation, since it increased final neuronal production and enhanced the expression of specific neuronal genes: Nestin, Tuj1 and MAP2. Furthermore, during neuronal differentiation process, there was an increase in proliferative cell number (ki67 mRNA expressing cells) and a decrease in cell death (lower propidium iodide (PI) uptake, limitation of caspase-3 activation and higher Bcl-2 expressing cells). CO supplementation did not increase the expression of RA receptors. In the case of SH-S5Y5 model, small amounts of reactive oxygen species (ROS) generation emerges as important signaling molecules during CO-promoted neuronal differentiation. CO's improvement of neuronal differentiation yield was validated using OHSC as ex vivo model. CORM-A1 treatment of OHSC promoted higher levels of cells expressing the neuronal marker Tuj1. Still, CORM-A1 increased cell proliferation assessed by ki67 expression and also prevented cell death, which was followed by increased Bcl-2 expression, decreased levels of active caspase-3 and PI uptake. Likewise, ROS signaling emerged as key factors in CO

  7. Carbon Monoxide Releasing Molecule-A1 (CORM-A1 Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death.

    Ana S Almeida

    Full Text Available Cerebral ischemia and neurodegenerative diseases lead to impairment or death of neurons in the central nervous system. Stem cell based therapies are promising strategies currently under investigation. Carbon monoxide (CO is an endogenous product of heme degradation by heme oxygenase (HO activity. Administration of CO at low concentrations produces several beneficial effects in distinct tissues, namely anti-apoptotic and anti-inflammatory. Herein the CO role on modulation of neuronal differentiation was assessed. Three different models with increasing complexity were used: human neuroblastoma SH-S5Y5 cell line, human teratocarcinoma NT2 cell line and organotypic hippocampal slice cultures (OHSC. Cell lines were differentiated into post-mitotic neurons by treatment with retinoic acid (RA supplemented with CO-releasing molecule A1 (CORM-A1. CORM-A1 positively modulated neuronal differentiation, since it increased final neuronal production and enhanced the expression of specific neuronal genes: Nestin, Tuj1 and MAP2. Furthermore, during neuronal differentiation process, there was an increase in proliferative cell number (ki67 mRNA expressing cells and a decrease in cell death (lower propidium iodide (PI uptake, limitation of caspase-3 activation and higher Bcl-2 expressing cells. CO supplementation did not increase the expression of RA receptors. In the case of SH-S5Y5 model, small amounts of reactive oxygen species (ROS generation emerges as important signaling molecules during CO-promoted neuronal differentiation. CO's improvement of neuronal differentiation yield was validated using OHSC as ex vivo model. CORM-A1 treatment of OHSC promoted higher levels of cells expressing the neuronal marker Tuj1. Still, CORM-A1 increased cell proliferation assessed by ki67 expression and also prevented cell death, which was followed by increased Bcl-2 expression, decreased levels of active caspase-3 and PI uptake. Likewise, ROS signaling emerged as key factors

  8. Utility of gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage in premenopausal women with breast cancer: a systematic review and meta-analysis

    Shen YW

    2015-11-01

    Full Text Available Yan-Wei Shen,1 Xiao-Man Zhang,1 Meng Lv,1 Ling Chen,1 Tian-Jie Qin,1 Fan Wang,1 Jiao Yang,1 Pei-Jun Liu,2 Jin Yang1 1Department of Medical Oncology, 2Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China Background: Premature ovarian failure and infertility following chemotherapy are major concerns for premenopausal women with breast cancer. A potential ovarian function preservation strategy is administration of gonadotropin-releasing hormone (GnRH agonists during adjuvant chemotherapy; however, studies of the clinical efficacy of GnRH agonists to protect chemotherapy-induced ovarian damage have shown mixed results. Objective: This meta-analysis study was designed to estimate the efficacy of GnRH agonists administered concurrently with chemotherapy to prevent chemotherapy-induced ovarian damage in premenopausal women with breast cancer. Methods: Electronic literature databases (PubMed, EMBASE, MEDLINE, Cochrane Library databases searching, China National Knowledge Infrastructure, Web of Science, and the Wanfang Data were searched for relevant randomized controlled trials (RCTs published until September 2015. Only RCTs that examined the effect of GnRH agonists for chemotherapy-induced ovarian failure in premenopausal women with breast cancer were selected. The rate of spontaneous resumption of menses and spontaneous pregnancy were collected. All data were analyzed by RevMan 5.3 (Cochrane Collaboration, Copenhagen, Denmark and Stata 12.0 (StataCorp, College Station, TX, USA. Results: Eleven RCTs with a total of 1,062 participants (GnRH agonists administered concurrently with chemotherapy, n=541; chemotherapy alone, n=521 were included in the meta-analysis. A significantly greater number of women treated with GnRH agonist experienced spontaneous resumption of menses after the adjuvant chemotherapy, yielding a pooled odds ratio of 2.57 (versus chemotherapy alone, 95

  9. Accidental Electric Shock during Pregnancy: Reflection on a Case

    Johnny Awwad

    2013-10-01

    Full Text Available Objectives - Data on fetal effects following accidental electric shock during pregnancy are scarce. We report on a case of accidental maternal electric shock associated with benign fetal arrhythmia in a woman at 28 weeks' gestation. Study Design - Case report. Results - Although electrocution involving low-voltage, low-frequency current has been associated with fatal cardiac arrhythmias and conduction abnormalities, two protective parameters in the present case likely reduced the fetal injury: the dry skin at the site of current entry and the hand-to-hand pathway of current flow. Conclusion - Because the pathophysiology of electric injury is altered during pregnancy, assessment of fetal well-being should be prompted no matter how trivial an incident may appear.

  10. Accidental Electric Shock during Pregnancy: Reflection on a Case.

    Awwad, Johnny; Hannoun, Antoine; Fares, Farah; Ghazeeri, Ghina

    2013-10-01

    Objectives Data on fetal effects following accidental electric shock during pregnancy are scarce. We report on a case of accidental maternal electric shock associated with benign fetal arrhythmia in a woman at 28 weeks' gestation. Study Design Case report. Results Although electrocution involving low-voltage, low-frequency current has been associated with fatal cardiac arrhythmias and conduction abnormalities, two protective parameters in the present case likely reduced the fetal injury: the dry skin at the site of current entry and the hand-to-hand pathway of current flow. Conclusion Because the pathophysiology of electric injury is altered during pregnancy, assessment of fetal well-being should be prompted no matter how trivial an incident may appear.

  11. Accidental degeneracy of double Dirac cones in a phononic crystal

    Chen, Ze-Guo

    2014-04-09

    Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

  12. Leading global projects for professional and accidental project leaders

    Moran, Robert T

    2008-01-01

    This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

  13. Release mitigation spray safety systems for chemical demilitarization applications.

    Leonard, Jonathan; Tezak, Matthew Stephen; Brockmann, John E.; Servantes, Brandon; Sanchez, Andres L.; Tucker, Mark David; Allen, Ashley N.; Wilson, Mollye C.; Lucero, Daniel A.; Betty, Rita G.

    2010-06-01

    Sandia National Laboratories has conducted proof-of-concept experiments demonstrating effective knockdown and neutralization of aerosolized CBW simulants using charged DF-200 decontaminant sprays. DF-200 is an aqueous decontaminant, developed by Sandia National Laboratories, and procured and fielded by the US Military. Of significance is the potential application of this fundamental technology to numerous applications including mitigation and neutralization of releases arising during chemical demilitarization operations. A release mitigation spray safety system will remove airborne contaminants from an accidental release during operations, to protect personnel and limit contamination. Sandia National Laboratories recently (November, 2008) secured funding from the US Army's Program Manager for Non-Stockpile Chemical Materials Agency (PMNSCMA) to investigate use of mitigation spray systems for chemical demilitarization applications. For non-stockpile processes, mitigation spray systems co-located with the current Explosive Destruction System (EDS) will provide security both as an operational protective measure and in the event of an accidental release. Additionally, 'tented' mitigation spray systems for native or foreign remediation and recovery operations will contain accidental releases arising from removal of underground, unstable CBW munitions. A mitigation spray system for highly controlled stockpile operations will provide defense from accidental spills or leaks during routine procedures.

  14. 2006-2011年五华县居民意外死亡分析%Accidental Death of Residents in Wuhua County, 2006-2011

    沈超华; 周荣群; 陈青山; 张聪

    2013-01-01

    目的 了解五华县居民意外死亡情况及变化趋势,为制定相应防控策略提供科学依据.方法 对2006-2011年五华县全人群死因监测资料中的意外死亡资料进行整理分析.结果 2006-2011年意外死亡2 328人,年均死亡率30.18/10万,占全死因的6.46%,居全死因第5位.男、女性意外死亡率分别为39.38/10万和20.43/10万,男性高于女性.前5位意外死因是机动车辆交通事故、淹死、自杀、意外跌落和意外中毒.除0岁组外,意外死亡率随年龄的增长而上升,0~4岁和5~14岁年龄段人群主要意外死因为淹死,分别占该年龄段意外死亡的63.58%和57.08%,15岁及以上人群主要意外死因为机动车辆交通事故,25~59岁青壮年第2位意外死因为自杀,60岁以上人群第2位意外死因为意外跌落.结论 意外伤害已经成为五华县居民的主要死因之一,机动车辆交通事故、淹死、自杀是主要意外死因,应加大关注力度,全面落实伤害三级预防措施.%Objective To investigate the trend of accidental death in Wuhua county, in order to provide the scientific basis for formulate the corresponding prevention and control strategy. Methods Collecting and analyzing the accidental death deta of all populations death monitoring data in Wuhua county in 2006 to 2011 years. Results 2328 people were accidental death, the average mortality rate was 30. 18/10 , accounted for 6. 46% and ranked No. 5 of all causes of death. The accidental death rate of male and female were 39. 38/105 and 20. 43/ 105 respectively. The rate of male was higher than that of female. The top of accidental death causes were motor vehicle traffic accident, drowning, suicide, accidental drop and accidental poisoning. Except the zero age group, the accidental death ascended following growing age. Drowning was the first accidental death cause of the groups of age 0 to 4 and age 5 tol4 years old, with the composition ratio of 63. 58% and 57. 08

  15. D-transallethrin: An unusual agent for accidental poisoning

    Vinod Kedari; Rajesh Kulkarni; Chhaya Valvi; Aarti Kinikar; Sandhya Khadse

    2016-01-01

    D-trans allethrin, a pyrethroid, is commonly used as a coil mosquito repellant. There are very few reports of human toxicity due to D-trans allethrin. We present the case of an 11-month-old boy who presented to us with excessive salivation, altered sensorium and convulsions following alleged accidental ingestion of a coil containing D-transallethrin. He required mechanical ventilation for a brief period and made a full recovery. Although rare, the possibility of pyrethroid poisoning should be...

  16. Accidental surface contamination - The effect on trace element analysis

    Franklyn, C.B. E-mail: franklyn@aec.co.za; Ueckermann, H.; Merkle, R.K.W

    2001-07-01

    We discuss the accidental contamination of samples during a micro-PIXE study of Rh, Pd and Pt partition coefficients in the Fe-S and Ni-S systems. Trace amounts of Ni and Cu, mounted separately in epoxy as markers, were found to be present in various phases in the sections, sometimes selectively in specific mineral phases. This contamination is believed to result from polishing during preparation. Further surface contamination from conductive Ag paste was also observed.

  17. Accidental IV administration of epinephrine instead of midazolam at colonoscopy

    Ahmed Gado

    2016-03-01

    Full Text Available Drug administration errors appear to be a major source of iatrogenic harm to hospitalized patients. They often, particularly in the case of epinephrine, have catastrophic consequences both for the patient and the well-meaning provider. The following incident is a medication error case report which illustrates one way that incorrect medication may be administered. IV epinephrine was accidentally administered instead of midazolam at colonoscopy.

  18. Complications following an accidental sodium hypochlorite extrusion: A report of two cases

    Bosch-Aranda, María L.; Canalda-Sahli, Carlos; Gay-Escoda, Cosme

    2012-01-01

    Sodium hypochlorite (NaOCl) is the most commonly used solution in root canal treatments, as it is a low-cost method that displays a very effective antimicrobial activity against microbiota of infected root canals. However, this solution can cause complications especially due to its cytotoxic features. When this solution is injected into the adjacent tissues, the patient usually experiences intense pain, and an urgent treatment should be implemented in order to prevent a long-term sequelae. This paper describes the clinical features of two patients that experienced an accidental extrusion of NaOCl after endodontic treatment of varying severity and with different treatments. Furthermore, it shows the long-term neurologic injuries that this type of accidents may cause and a treatment protocol for these situations will be suggested. Key words:Nerve damage, root canal irrigation, root canal treatment, sodium hypochlorite. PMID:24558554

  19. Necrotizing fasciitis due to Streptococcus mitis caused by accidental human bite.

    Bastug, Aliye; Kislak, Sumeyye; Mutlu, Nevzat Mehmet; Akcaboy, Zeynep Nur; Koksal, Asude; Sertcelik, Ahmet; Ünlü, Ramazan Erkin; Akinci, Esragul; Bodur, Hurrem

    2016-01-31

    Human bite wounds are more prone to infection than animal bites, which may cause necrotizing soft tissue infections such as myositis, fasciitis. Both aerobic and anaerobic microorganisms may be responsible, including Streptococcus spp., Staphylococcus aureus, Peptostreptococcus spp. Necrotizing fasciitis is characterized by serious tissue destruction and systemic toxicity with high morbidity and mortality. We report a patient with Streptococcus mitis associated necrotizing fasciitis on the upper extremity resulting from an accidental human bite, which caused nearly fatal infection. Prophylactic antibiotic treatment should be given after a human bite to prevent infection. If the infection signs and symptoms develop, rapid diagnosis, appropriate antibiotic and surgical therapy should be administered immediately. Streptococcus mitis is a viridans streptococcus, usually known as a relatively benign oral streptococcus. To our knowledge, this is the first necrotizing fasciitis case due to Streptococcus mitis after human bite.

  20. "Dead in hot bathtub" phenomenon: accidental drowning or natural disease?

    Satoh, Fumiko; Osawa, Motoki; Hasegawa, Iwao; Seto, Yoshihisa; Tsuboi, Akio

    2013-06-01

    Sudden death in a hot bathtub occurs frequently in Japan, particularly among elderly people. This retrospective report describes the epidemiologic circumstances and physical findings at autopsy. In total, 268 victims were found unconscious or dead during tub bathing. After postmortem examination, the manner of death was judged as natural cause in 191 (71.2%) and accidental drowning in 63 (23.5%) cases. Mean age (SD) was 72.1 (15.2) years with no significant difference between males and females. A seasonal difference was evident: the winter displayed the highest frequency. Drowning water inhalation, which was confirmed in 72% of victims, was absent in the others. The most common observations on postmortem examination were cardiac ischemic changes and cardiomegaly. Water inhalation signs were evident in a significantly fewer victims exhibiting these factors. In contrast, inhalational findings were observed more frequently in victims with other backgrounds such as alcohol intake, mobility disturbance, and history of epilepsy. Annual mortality in Japan from accidental drowning in persons aged older than 75 years is 33 deaths per 100,000 population. However, this number may be considerably underestimated as pathologists tend to regard lack of water inhalation as indicating a natural cause of death. Confusion in diagnosis remains consequent to the accidental and natural aspects of "dead in hot bathtub" phenomenon.

  1. Accidental falls involving medical implant re-operation.

    Ong, Kevin L; Lau, Edmund; Moore, Tara; Heller, Michelle F

    2009-10-01

    Implantation of medical devices is becoming more prevalent, and as a result, a greater number of patients who fall accidentally are expected to have a medical implant. The Nationwide Inpatient Sample (NIS) was used to evaluate hospital admissions following accidental falls involving re-operation of existing medical implants (hip, knee, spine, and fracture fixation) from 1990 to 2005. From 1990 to 2005, hospitalisations due to accidental falls on level surfaces increased by 306%, and hospitalisations due to falls from stairs increased by 310%. Falls involving orthopaedic revision surgery (re-operation) are relatively rare, but the incidence has increased by approximately 35%. Hospital stays after falls on level surfaces involving re-operation were 1.0 day (median) longer and cost 50% (median) more than those that did not involve re-operation in 2005. After staircase falls, hospital stays for patients undergoing re-operations were 2.0 days (median) longer and cost 108% (median) more. The greater hospital costs and hospital stay for patients needing re-operations indicate that additional medical treatment was required.

  2. Disruption of lolCDE, Encoding an ATP-Binding Cassette Transporter, Is Lethal for Escherichia coli and Prevents Release of Lipoproteins from the Inner Membrane

    Narita, Shin-ichiro; Tanaka, Kimie; Matsuyama, Shin-ichi; Tokuda, Hajime

    2002-01-01

    ATP-binding cassette transporter LolCDE was previously identified, by using reconstituted proteoliposomes, as an apparatus catalyzing the release of outer membrane-specific lipoproteins from the inner membrane of Escherichia coli. Mutations resulting in defective LolD were previously shown to be lethal for E. coli. The amino acid sequences of LolC and LolE are similar to each other, but the necessity of both proteins for lipoprotein release has not been proved. Moreover, previous reconstituti...

  3. HIV Prevention

    2012-02-01

    Dr. Kevin Fenton, Director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, talks about steps people can take to protect their health from HIV.  Created: 2/1/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 2/1/2012.

  4. Relocation Impacts of a Major Release from SRTC

    Blanchard, A.

    1999-05-17

    The relocation impacts of an accidental release, scenario 1-RD-3 , are evaluated for the Savannah River Technology Center. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide is calculated.

  5. Working Inside for Smoking Elimination (Project W.I.S.E. study design and rationale to prevent return to smoking after release from a smoke free prison

    Mello Jennifer

    2011-10-01

    Full Text Available Abstract Background Incarcerated individuals suffer disproportionately from the health effects of tobacco smoking due to the high smoking prevalence in this population. In addition there is an over-representation of ethnic and racial minorities, impoverished individuals, and those with mental health and drug addictions in prisons. Increasingly, prisons across the U.S. are becoming smoke free. However, relapse to smoking is common upon release from prison, approaching 90% within a few weeks. No evidence based treatments currently exist to assist individuals to remain abstinent after a period of prolonged, forced abstinence. Methods/Design This paper describes the design and rationale of a randomized clinical trial to enhance smoking abstinence rates among individuals following release from a tobacco free prison. The intervention is six weekly sessions of motivational interviewing and cognitive behavioral therapy initiated approximately six weeks prior to release from prison. The control group views six time matched videos weekly starting about six weeks prior to release. Assessments take place in-person 3 weeks after release and then for non-smokers every 3 months up to 12 months. Smoking status is confirmed by urine cotinine. Discussion Effective interventions are greatly needed to assist these individuals to remain smoke free and reduce health disparities among this socially and economically challenged group. Trial Registration NCT01122589

  6. [Accidental intravenous injection of potassium chloride: analysis of contributing factors and barriers to risk reduction].

    Bonvin, A; Vantard, N; Charpiat, B; Pral, N; Leboucher, G; Philip-Girard, F; Viale, J-P

    2009-05-01

    Errors linked to injectable potassium chloride (KCl) have been the cause of deaths which have occurred for many years. Following an accidental direct intravenous injection of KCl of no clinical consequence for the patient, we have analyzed the contributive factors, established an action plan to prevent this risk and finally assessed its impact. Among the causes leading to medication errors, we have identified those linked to the handling of the drugs by nurses, the team, the work conditions, the organization, the institutional context and finally to the drug itself. The risk reduction procedure involved a withdrawal of injectable KCI ampoules from wards, possible in 52% of the care units, a reorganization of storage for the others. The subsequent monitoring of floorstocks revealed that these measures were insufficient and that the risks prevailed due to the presence of KCI ampoules in drawers assigned to other ionic solutions. A study carried out among the medical and nursing personnel revealed that 61.2% of the doctors thought that the risk existed in their ward and 68% of the nurses considered themselves to be exposed to the risk of a medication error. The drug supply chain of our institution, as in numerous others, is not safe. Hospitals are not yet organized adequately to prevent the occurrence of such an error. The comparison with foreign organizations of drug dispensation allows us to think that the improvement and professionalization of the drug supply chain will both be assets in the prevention of such medication errors.

  7. Sheltering in buildings from large-scale outdoor releases

    Chan, W.R.; Price, P.N.; Gadgil, A.J.

    2004-06-01

    Intentional or accidental large-scale airborne toxic release (e.g. terrorist attacks or industrial accidents) can cause severe harm to nearby communities. Under these circumstances, taking shelter in buildings can be an effective emergency response strategy. Some examples where shelter-in-place was successful at preventing injuries and casualties have been documented [1, 2]. As public education and preparedness are vital to ensure the success of an emergency response, many agencies have prepared documents advising the public on what to do during and after sheltering [3, 4, 5]. In this document, we will focus on the role buildings play in providing protection to occupants. The conclusions to this article are: (1) Under most circumstances, shelter-in-place is an effective response against large-scale outdoor releases. This is particularly true for release of short duration (a few hours or less) and chemicals that exhibit non-linear dose-response characteristics. (2) The building envelope not only restricts the outdoor-indoor air exchange, but can also filter some biological or even chemical agents. Once indoors, the toxic materials can deposit or sorb onto indoor surfaces. All these processes contribute to the effectiveness of shelter-in-place. (3) Tightening of building envelope and improved filtration can enhance the protection offered by buildings. Common mechanical ventilation system present in most commercial buildings, however, should be turned off and dampers closed when sheltering from an outdoor release. (4) After the passing of the outdoor plume, some residuals will remain indoors. It is therefore important to terminate shelter-in-place to minimize exposure to the toxic materials.

  8. 78 FR 6149 - Final Interim Staff Guidance Assessing the Radiological Consequences of Accidental Releases of...

    2013-01-29

    ... supplements NUREG-0800 Standard Review Plan (SRP) Section 11.2 and Branch Technical Position 11-6 and ISG-014... contained in NUREG-0800, SRP dated March 2007. The NRC staff intends to incorporate these final ISGs into the next revision of RG 1.206 and NUREG-0800. On February 24, 2010 (75 FR 8411 and 75 FR 8412),...

  9. UF6泄漏事故分析%Analysis of Accidental UF6 Releases

    范育茂; 覃锐; 高起发

    2012-01-01

    作为铀燃料富集过程的中间物质,UF6被广泛地应用于铀转化厂、铀富集厂和核燃料元件厂.由于其化学性质活泼,且兼有放射性辐射和化学危害,故需要对UF6泄漏事故予以高度重视.本文介绍了UF6水解反应过程,分析了UF6意外泄漏情况下可能的释放类型、途径和扩散特征.结果表明,事故情况下UF6的释放不是简单的被动扩散过程,需要采用特定的大气扩散模型才能对其事故后果或影响进行较为准确的分析和评估.

  10. A risk assessment method for accidental releases from nuclear power plants in Europe

    Slaper H; Blaauboer RO; Eggink GJ

    1994-01-01

    At present over 200 nuclear power reactors are operational. The question raised is to what extent possible accidents with nuclear power reactors pose a risk for the European population. In this report a method is described for evaluating the probability of death due to stochastic effects, combinin

  11. Accumulation of plutonium in mammalian wildlife tissues following dispersal by accidental-release tests.

    Johansen, M P; Child, D P; Caffrey, E A; Davis, E; Harrison, J J; Hotchkis, M A C; Payne, T E; Ikeda-Ohno, A; Thiruvoth, S; Twining, J R; Beresford, N A

    2016-01-01

    We examined the distribution of plutonium (Pu) in the tissues of mammalian wildlife inhabiting the relatively undisturbed, semi-arid former Taranaki weapons test site, Maralinga, Australia. The accumulation of absorbed Pu was highest in the skeleton (83% ± 6%), followed by muscle (10% ± 9%), liver (6% ± 6%), kidneys (0.6% ± 0.4%), and blood (0.2%). Pu activity concentrations in lung tissues were elevated relative to the body average. Foetal transfer was higher in the wildlife data than in previous laboratory studies. The amount of Pu in the gastrointestinal tract was highly elevated relative to that absorbed within the body, potentially increasing transfer of Pu to wildlife and human consumers that may ingest gastrointestinal tract organs. The Pu distribution in the Maralinga mammalian wildlife generally aligns with previous studies related to environmental exposure (e.g. Pu in humans from worldwide fallout), but contrasts with the partitioning models that have traditionally been used for human worker-protection purposes (approximately equal deposition in bone and liver) which appear to under-predict the skeletal accumulation in environmental exposure conditions.

  12. The Chernobyl – Thirty Years After The Post – Accidental Radiological – Hygienic and Medical Consequences

    G. G. Onishchenko

    2016-01-01

    Full Text Available As the result of the Chernobyl NPP accident more than 200 thousand square kilometers of the European territories were contaminated by Cs-137 in the amount of above 37 kBq/m2 (1 Ci/km2 . Belorussia, Russia and Ukraine amount up to 70% of this entire affected area. More than 600 000 people were engaged in the accidental cleanup operations, 340000 were evacuated or relocated within 1986-1991. The early stage evacuation efficacy is confirmed by the absence of acute radiation syndrome among the population and by the prevented collective dose which amounts to no less than 10 000 man/Sv. The effective measure to reduce the internal radiation dose to the population at the early accidental stage was introduction of maximum tentative permissive levels of radionuclide content in the foodstuffs.Among the identified post -accident medical consequences of the Chernobyl is the radiation syndrome found in 134 emergency cleanup workers within the first 24 hours of the accident’s development. Out of that number, 28 people died within the first four months, 19 people died before 2006. The accident’s liquidators developed radiation -induced leukemia ( the attributive risk value is 45-60% . People exposed to high radiation doses display the statistically significant 18% morbidity increase of all types of solid cancers at the doses above 150 mSv. There is the statistically significant information indicating the increased amount of thyroid cancer morbidity among those who were just children and teenagers at the time of the accident. The adverse psychological consequences are accounted for not just the fear of overexposure but also for the disturbance of the habitual lifestyle especially mindful of the forced relocation.The longterm protection measures, radionuclide decay and selfcleaning of the contaminated areas resulted in the drastic reduction of the population dose in the radioactively contaminated territories. In 2015, only in some settlements of the Briansk

  13. Accidental Degeneracy and Berry Phase of Resonant States

    Mondragón, A

    1997-01-01

    We study the complex geometric phase acquired by the resonant states of an open quantum system which evolves irreversibly in a slowly time dependent environment. In analogy with the case of bound states, the Berry phase factors of resonant states are holonomy group elements of a complex line bundle with structure group C*. In sharp contrast with bound states, accidental degeneracies of resonances produce a continuous closed line of singularities formally equivalent to a continuous distribution of "magnetic" charge on a "diabolical" circle, in consequence, we find different classes of topologically inequivalent non-trivial closed paths in parameter space.

  14. D-transallethrin: An unusual agent for accidental poisoning

    Vinod Kedari

    2016-01-01

    Full Text Available D-trans allethrin, a pyrethroid, is commonly used as a coil mosquito repellant. There are very few reports of human toxicity due to D-trans allethrin. We present the case of an 11-month-old boy who presented to us with excessive salivation, altered sensorium and convulsions following alleged accidental ingestion of a coil containing D-transallethrin. He required mechanical ventilation for a brief period and made a full recovery. Although rare, the possibility of pyrethroid poisoning should be kept in mind in children who present with sudden onset unconsciousness or convulsions.

  15. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application

    Michael Froehle

    2012-01-01

    Full Text Available Mepivacaine is a potent local anaesthetic and used for infiltration and regional anaesthesia in adults and pediatric patients. Intoxications with mepivacaine affect mainly the CNS and the cardiovascular system. We present a case of accidental intravenous mepivacaine application and intoxication of an infant resulting in seizure, broad complex bradyarrhythmia, arterial hypotension and finally cardiac arrest. The patient could be rescued by prolonged resuscitations and a rapid initiation of ECMO and survived without neurological damage. The management strategies of this rare complication including promising other treatment options with lipid emulsions are discussed.

  16. Accidente Isquémico Transitorio: la gran oportunidad

    Mª Dolores Fernández Couto

    2013-09-01

    Full Text Available El ictus constituye la primera causa de muerte en mujeres y la segunda causa de muerte global en España1, así como la primera causa de discapacidad adquirida en la edad adulta y la segunda causa de demencia por detrás de la enfermedad de Alzheimer. El accidente isquémico transitorio (AIT precede al ictus isquémico en un 23% de los casos2. Esta señal de alarma, lejos de poder considerarse banal, constituye una gran oportunidad para la prevención.

  17. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    Domingo García, AM

    2006-01-01

    RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas ...

  18. Clinical perspectives on osteogenesis imperfecta versus non-accidental injury.

    Pereira, Elaine Maria

    2015-12-01

    Although non-accidental injuries (NAI) are more common in cases of unexplained fractures than rare disorders such as osteogenesis imperfecta (OI), ruling out OI and other medical causes of fracture is always indicated. The majority of OI patients can be diagnosed with the help of family history, physical examination, and radiographic findings. In particular, there are a few radiological findings which are seen more commonly in NAI than in OI which may help guide clinician considerations regarding the probability of either of these diagnoses. At the same time, molecular testing still merits careful consideration in cases with unexplained fractures without obvious additional signs of abuse.

  19. Measurement of accidental coincidences for higher activity sources

    Yull Hwang, H; Jae-Oh, P; Man-Lee, J; Kie-Lee, M

    1999-01-01

    The multi-channel time-scaling (MCTS) technique has been applied for the measurement of accidental coincidences for the cases of higher activity samples in beta-gamma coincidence counting. Two beta samples of sup 1 sup 3 sup 4 Cs were prepared and the nominal activities observed in the beta counter were about 7000 and 11000 s sup - sup 1 , respectively. The obtained true coincidence rates are independent of resolving times and dead times. They are compared with those calculated from the mathematical model derived by Cox and Isham.

  20. Accidentes de trabajo en un hospital de agudos

    Pérez Bermúdez B.

    1998-01-01

    Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

  1. Costes e Investigación de Accidentes Laborales

    Gonzalez Quintana, Jon Ander

    2013-01-01

    En España en el año 2011, según datos del Instituto Nacional de Estadística (INE), se registraron 581.150 accidentes con baja laboral de los cuales el 88% sucedieron dentro de jornada laboral. Observando estas cifras, es obvio que hay una carencia en el sistema preventivo y, por los tanto, es necesario buscar una solución. Son tres los factores de la baja inversión en prevención: la falta de concienciación de las empresas, la falta del conocimiento de las consecuencias de un...

  2. Prevent Pneumonia

    2015-08-06

    CDC’s Matthew Westercamp explains what pneumonia is, its symptoms, and how to prevent it.  Created: 8/6/2015 by National Center for Immunization and Respiratory Diseases (NCIRD), Division of Bacterial Diseases (DBD), Respiratory Diseases Branch (RDB).   Date Released: 8/6/2015.

  3. High dose gonadotrophin-releasing hormone antagonist (ganirelix) may prevent ovarian hyperstimulation syndrome caused by ovarian stimulation for in-vitro fertilization

    D. de Jong (Danielle); N.S. Macklon (Nick); B.M. Mannaerts; H.J. Coelingh Bennink; B.C.J.M. Fauser (Bart)

    1998-01-01

    textabstractThis case report describes the first attempt to treat imminent ovarian hyperstimulation syndrome (OHSS) by using a gonadotrophin-releasing hormone (GnRH) antagonist. A 33 year old, normo-ovulatory woman undergoing in-vitro fertilization received daily subcut

  4. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release

    Prince, Robin N.; Schreiter, Eric R.; Zou, Peng; Wiley, H. S.; Ting, Alice Y.; Lee, Richard T.; Lauffenburger, Douglas A.

    2010-07-01

    Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree of proteolytic release of the ligand. Although the spatial range of diffusion of released HB-EGF is restricted by binding heparan-sulfate proteoglycans (HSPGs) in the extracellular matrix and/or cellular glycocalyx, ascertaining mechanisms governing non-released HB-EGF localization is also important for understanding its effects. We have employed a new method for independently tracking the localization of the extracellular EGFlike domain of HB-EGF and the cytoplasmic C-terminus. A striking observation was the absence of the HB-EGF transmembrane proform from the leading edge of COS-7 cells in a wound-closure assay; instead, this protein localized in regions of cell-cell contact. A battery of detailed experiments found that this localization derives from a trans interaction between extracellular HSPGs and the HBEGF heparin-binding domain, and that disruption of this interaction leads to increased release of soluble ligand and a switch in cell phenotype from juxtacrine-induced growth inhibition to autocrine-induced proliferation. Our results indicate that extracellular HSPGs serve to sequester the transmembrane pro-form of HB-EGF at the point of cell-cell contact, and that this plays a role in governing the balance between juxtacrine versus autocrine and paracrine signaling.

  5. Typical occupational accidents with employees of a university hospital in the south of Brazil: epidemiology and prevention Accidentes de trabajo típicos de trabajadores de un hospital universitario de la región sur de Brasil: epidemiología y prevención Acidentes de trabalho típicos envolvendo trabalhadores de hospital universitário da região sul do Brasil: epidemiologia e prevenção

    Iara Aparecida de Oliveira Sêcco

    2008-10-01

    Full Text Available Descriptive epidemiologic study that aimed to analyze the typical occupational accidents notified by employees of a university hospital in the South of Brazil from 1997 to 2002, and to estimate their risk indicators. A total of 717 accidents were registered; 86% of them (616 were typical and presented an annual average risk coefficient of 6.0 per 100 employees. The groups that presented more risks for accidents were cooks, woodworkers and nursing auxiliaries, while hands were the most affected area. Regarding the accidents nature, the greatest risks involved biological material. Hence, it is necessary to orient personnel about the legal aspects of occupational accidents and review work processes, especially those related to employees who perform activities at greater risk of transmissible diseases like AIDS and hepatitis B and C.Se trata de un estudio epidemiológico descriptivo que tuvo como objetivo analizar los accidentes de trabajo típicos notificados por los trabajadores de un hospital universitario de la región sur de Brasil, de 1997 a 2002 y estimar indicadores de riesgo. Fueron notificados 717 accidentes, siendo 86% (616 típicos, cuyo Coeficiente de Riesgo Promedio Anual fue igual a 6,0 accidentes a cada 100 trabajadores. Los equipos que corrieron los mayores riesgos de sufrir tales accidentes fueron los de los cocineros, carpinteros y auxiliares de enfermería, siendo las manos la parte del cuerpo más afectada. En cuanto a la naturaleza de los accidentes, los de mayor riesgo fueron los relacionados a materiales biológicos. Se constató la necesidad de orientar al personal sobre los aspectos legales de los accidentes y revisar los procesos de trabajo desarrollados, especialmente para los que actúan en funciones cuyos riesgos son mayores de contraer enfermedades graves como SIDA y Hepatitis B y C.Estudo epidemiológico descritivo objetivou analisar os acidentes de trabalho típicos notificados pelos trabalhadores de um hospital

  6. Savannah River Site Ingestion Pathway Methodology Manual for Airborne Radioactive Releases

    Vincent, A.W. III

    2001-01-03

    This manual documents a recommended methodology for determining the ingestion pathway consequences of hypothetical accidental airborne radiological releases from facilities at the Savannah River Site. Both particulate and tritiated radioactive contaminants are addressed. Other approaches should be applied for evaluation of routine releases.

  7. Multidisciplinary approach to "accidental" falls in the elderly: a case report.

    Galizia, Gianluigi; Testa, Gianluca; Mazzella, Francesca; Cacciatore, Francesco; Ungar, Andrea; Masotti, Giulio; Rengo, Franco; Abete, Pasquale

    2008-06-01

    Falls in the elderly are commonly and often wrongly identified as "accidental". We report a case of an elderly woman admitted to first aid for a trauma due to an accidental fall. Geriatric multidisciplinary evaluation revealed mild cognitive impairment associated with depressive symptoms; both findings made the anamnesis uncertain. Syncope algorithm was applied and "tachy-brady form of sick sinus syndrome" was diagnosed. Differential diagnosis between "accidental" and "apparently accidental" falls in elderly patients is very difficult but a multidisciplinary geriatric evaluation can clarify the correct diagnosis.

  8. Pathological Findings in Accidental Electrocution in a Horse (Case Report

    Adrian Florin Gal

    2016-11-01

    Full Text Available Recently, the veterinarians are dealing with a number of cases that require forensic expertise. Such a circumstance could be the accidental electrocution in animals, one of the causes of unnatural death. There is a scarcity with reference to the pathological findings in veterinary forensic medicine. In this paper, we present the main lesions that occurred in a horse with accidental electrocution that was presented for complete necropsy survey. A horse corpse was sent to the Pathology Department (Faculty of Veterinary Medicine, Cluj-Napoca, Romania for a full medical survey. Preliminary results and external examination: the body was in rigor mortis; from the nasal cavities drained out reddish foam and in the mouth was observed the presence of ingested feed (straw that was not chewed, suggesting a quick death. The findings detected after internal examination of the carcass were poor blood coagulability, haemorrhagic diathesis throughout the body, with haemorrhages of various sizes in different body regions (e.g., muscles of the withers, in the gluteal muscle, the mucosa of epiglottis, larynx, trachea, in the interstitium of the lung, and ecchymosis in the left kidney. Some other lesions detected were infarcts and haemorrhages in the fundic region of the stomach’s mucosa. In electrocution, haemorrhages are most often located in the respiratory tract, aspect observed in our case too. However, the diagnosis of electrocution has to corroborate the necropsy findings (which are not specific, with some other data such as the fulminant death and inspection of power source.

  9. accidentes y otras causas violentas en la sierra de Sonora

    Héctor Eloy Rivas Sánchez

    2005-01-01

    Full Text Available Este artículo presenta los resultados de una investigación sociológica cuyo objeto fue explorar el papel que ha jugado el modelo hegemónico de masculinidad en la ocurrencia de muertes derivadas de accidentes y varias formas de ejercicio de la violencia en una comunidad rural de la sierra de Sonora. Estos resultados difieren de aquellos que tradicionalmente los estudios de las masculinidades han mostrado para México y América Latina. El modelo dominante de masculinidad en las comunidades estudiadas no ha condicionado significativamente la ocurrencia de las muertes por accidentes y otras causas violentas. La responsabilidad, la disciplina y el respeto hacia las personas consideradas socialmente débiles (mujeres, ancianos y niños, principalmente son características que debe poseer un hombre de verdad en las comunidades estudiadas. El apego de los hombres a estas formas de comportamiento y su temor a perder honorabilidad como hombre de verdad si se desvían de estas normas de conducta los ha llevado a evitar una serie de prácticas temerarias que pudieron poner en riesgo su vida y la de otras personas.

  10. Normal neurologic and developmental outcome after an accidental intravenous infusion of expressed breast milk in a neonate.

    Ryan, C Anthony

    2012-02-03

    Here we describe a premature male infant who was accidentally given 10 mL of expressed breast milk intravenously over a 3.5-hour period. Having survived this event with supportive care, this boy was attending regular school with no obvious neurologic or learning difficulties at 6 years of age. In 1998, after a query on an e-mail discussion group for health care providers in neonatology (NICU-net), we were informed of 8 similar events that proved fatal in 3 infants. A root-cause analysis revealed that accidental intravenous administration of breast milk or formula can be avoided by the use of color-coded enteral-administration sets with Luer connections that are not compatible with intravenous cannulas. The addition of methylene blue to feeds, or bolus enteral feeds (instead of continuous gastric feedings), may also help prevent such errors. These cases show the value of gathering information about rare but important events through a neonatal network. In addition, they confirm that prevention of medical error should focus on faulty systems rather than faulty people.

  11. Medicare Program; Revisions to Payment Policies Under the Physician Fee Schedule and Other Revisions to Part B for CY 2017; Medicare Advantage Bid Pricing Data Release; Medicare Advantage and Part D Medical Loss Ratio Data Release; Medicare Advantage Provider Network Requirements; Expansion of Medicare Diabetes Prevention Program Model; Medicare Shared Savings Program Requirements. Final rule.

    2016-11-15

    This major final rule addresses changes to the physician fee schedule and other Medicare Part B payment policies, such as changes to the Value Modifier, to ensure that our payment systems are updated to reflect changes in medical practice and the relative value of services, as well as changes in the statute. This final rule also includes changes related to the Medicare Shared Savings Program, requirements for Medicare Advantage Provider Networks, and provides for the release of certain pricing data from Medicare Advantage bids and of data from medical loss ratio reports submitted by Medicare health and drug plans. In addition, this final rule expands the Medicare Diabetes Prevention Program model.

  12. [Accidental hypothermia in adults: taking charge by the SAMU of Paris].

    Deny, N; Bresard, D; Bertrand, J; Poisvert, M

    1990-02-01

    Thirty one cases of accidental hypothermia have been taken in care by the SAMU de Paris during the year of 1987. The accidental hypothermias happening in the cities are, most of the time, moderated and not very serious. The search for a cause is a prime necessity. The prognosis is based on that search to guide and advise the patients.

  13. Accidental Perforation of Endotracheal Tube during Orthognathic Surgery for Maxillary Prognathism - a Case Report

    Manish Jain

    2008-01-01

    Full Text Available Maxillary prognathism(excess is a congenital anomaly characterized by facial disfigurement. Accidental perforation of endotracheal tube during corrective surgery is not an uncommon complication. A case of accidental perforation of endotracheal tube during surgery and its management is presented here.

  14. A novel method to detect accidental oesophageal intubation based on ventilation pressure waveforms

    Kalmar, Alain F.; Absalom, Anthony; Monsieurs, Koenraad G.

    2012-01-01

    Background: Emergency endotracheal intubation results in accidental oesophageal intubation in up to 17% of patients. This is frequently undetected thereby adding to the morbidity and mortality. No current method to detect accidental oesophageal intubation in an emergency setting is both highly sensi

  15. Two Cases of Accidental Injection of Epinephrine into a Digit Treated with Subcutaneous Phentolamine Injections

    Ryan P. Bodkin

    2013-01-01

    Full Text Available Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine injection with no adverse events.

  16. 76 FR 73021 - Agency Information Collection (Report of Accidental Injury in Support of Claim for Compensation...

    2011-11-28

    ... Injury in Support of Claim for Compensation or Pension/Statement of Witness to Accident, VA Form 21- 4176...: VA Form 21-4176 is used to support a claim for disability benefits based on an accidental injury that... AFFAIRS Agency Information Collection (Report of Accidental Injury in Support of Claim for Compensation...

  17. Accidental intraoral formalin injection: a rare case report

    Ramakant Dandriyal

    2014-12-01

    Full Text Available Formalin is a hazardous chemical that needs cautious handling and special storage. Owing to its disinfectant and fixative (i.e. for preserving pathologic tissue specimens in histopathology properties, it is widely used in dentistry. Although, the terms formaldehyde and formalin are often confused as being identical, these are different as to the concentrations of the primary component i.e. formaldehyde. In fact, the common fixative available as 10% neutral buffered formalin is actually a 4% solution of formaldehyde (i.e., a 10% solution made from a 37-40% commercially pure formaldehyde solution. This case report describes an unfortunate case of accidental injection instead of local anesthetic, of formalin into the pterygomandibular space in a 35-year old woman during inferior alveolar nerve block for surgical removal of impacted lower right third molar and its successful management by cautious debridement (under both local and general anesthesia and empirical drug therapy (utilizing analgesics and antibiotics.

  18. Accidental intraoral formalin injection: a rare case report.

    Dandriyal, Ramakant; Giri, Kolly Yada; Alam, Sarwar; Singh, Aishwarya Pratap

    2014-10-30

    Formalin is a hazardous chemical that needs cautious handling and special storage. Owing to its disinfectant and fixative (i.e. for preserving pathologic tissue specimens in histopathology) properties, it is widely used in dentistry. Although, the terms formaldehyde and formalin are often confused as being identical, these are different as to the concentrations of the primary component i.e. formaldehyde. In fact, the common fixative available as 10% neutral buffered formalin is actually a 4% solution of formaldehyde (i.e., a 10% solution made from a 37-40% commercially pure formaldehyde solution). This case report describes an unfortunate case of accidental injection instead of local anesthetic, of formalin into the pterygomandibular space in a 35-year old woman during inferior alveolar nerve block for surgical removal of impacted lower right third molar and its successful management by cautious debridement (under both local and general anesthesia) and empirical drug therapy (utilizing analgesics and antibiotics).

  19. Accidental endoscopic finding of Anisakis simplex in human colon

    Aurelia Aloia

    2011-09-01

    Full Text Available Anisakidosis is a zoonotic disease caused by the ingestion of nematodes belonging to the family of Anisakidae. Human infection is caused by intake of raw or undercooked sea fish and cephalopods infested by Anisakis larvae. We present a case of accidental endoscopic finding of an alive nematode adhering to distal ascending colon in a 32 years old man, submitted to colonoscopy owing to recent onsets of rectal bleeding of likely hemorrhoidal origin. The nematode, removed from colon by means of biopsy forceps, has been identified as L3 larvae of A. simplex by a light microscope. Histological examination of intestinal mucosa showed a mild fibrosis of lamina propria, characterized by focal lymphocytic inflammation and scattered infiltration of eosinophils. The patient reported the intake of marinated anchovies 3 days before endoscopic examination.

  20. Dose assessment of an accidental exposure at the IPNS

    Campos Torres, M.M.

    1995-02-01

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose ranged from 550 mrem/min to 2850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenetic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem.

  1. Dose assessment of an accidental exposure at IPNS

    Torres, M.M.C.

    1996-05-01

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose rates ranged from 550 mrem/min to 2,850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem.

  2. Nodular goiter after occupational accidental exposure to radiation

    Pisarev, M.A. [Radiobiology, National Atomic Energy Commission, Buenos Aires (Argentina); Human Biochemistry, Uninversity of Buenos Aires, School of Medicine, Buenos Aires (Argentina); Schnitman, M. [Center of Endocrinology and Metabolism, French Hospital C.Milstein, Buenos Aires (Argentina)

    2012-07-01

    In the present paper we present the consequences of an accidental occupational radiation exposure at a local hospital in Buenos Aires. Control at a local radiology service showed the lack of correct shielding in the X-ray equipment. The physicians and technicians (14 persons) exposed to radiation during 12 months were examined. The survey shows that: a) In 11 out of 14 radiation-exposed patients nodular goiter developed and an additional patient had diffuse goiter which means a goiter incidence of 85.7%; b) In 5 of the nodular goiter patients an increase in the size or the appearance of new nodules was observed along the follow-up period. No cancer was detected by FNA; c) Hypothyroidism was observed in 3/14 patients, and an additional patient had an abnormal TRH-TSH test, suggesting subclinical hypothyroidism; and d) Increased circulating antithyroid antibodies were found in one of the hypothyroid patients

  3. Application of biological dosimetry in accidental radiation exposure

    Nosal, M.; Batora, I.; Kolesar, D.; Stojkovic, J. (Komenskeho Univ., Bratislava (Czechoslovakia). Lekarska Fakulta); Gaal, P.; Sklovsky, A. (Krajska Hygienicka Stanica, Bratislava (Czechoslovakia)); Cizova, O. (Sexuologicka Ambulancia KUNZ, Bratislava (Czechoslovakia))

    1982-03-01

    The case is described of accidental irradiation of a male person with /sup 137/Cs of an activity of 24.71 GBq. The first estimate induced a reasonable suspicion that the absorbed dose could be very high and life-threatening. On the other hand the clinical picture, usual laboratory examinations, findings in the fluorescent blood count, the analysis of chromosomal count of lymphocytes in the peripheral blood, the spermiogram, and the negative post-irradiation porphyrinuria suggested that the absorbed dose could be much lower than the original estimate. The results of dosimetry obtained after the reconstruction of the accident by measuring on a phantom revealed that the actual dose was very close to that presumed from the results of biological dosimetry during the first days of examination of the patient.

  4. Siquieros accidental painting technique: a fluid mechanics point of view

    Zetina, Sandra

    2012-01-01

    This is an entry for the Gallery of Fluid Motion of the 65th Annual Meeting of the APS-DFD (fluid dynamics video). This video shows an analysis of the 'accidental painting' technique developed by D.A. Siqueiros, a famous Mexican muralist. We reproduced the technique that he used: pouring layers of paint of different colors on top of each other. We found that the layers mix, creating aesthetically pleasing patterns, as a result of a Rayleigh-Taylor instability. Due to the pigments used to give paints their color, they can have different densities. When poured on top of each other, if the top layer is denser than the lower one, the viscous gravity current undergoes unstable as it spread radially. We photograph the process and produced slowed-down video to visualize the process.

  5. Subtraction of "accidentals" and the validity of Bell tests

    Thompson, C H

    1999-01-01

    In some key Bell experiments, including two of the well-known ones by Alain Aspect, 1981-2, it is only after the subtraction of ``accidentals'' from the coincidence counts that we get violations of Bell tests. The data adjustment, producing increases of up to 60% in the test statistics, has never been adequately justified. Few published experiments give sufficient information for the reader to make a fair assessment. There is a straightforward and well known realist model that fits the unadjusted data very well. In this paper, the logic of this realist model and the reasoning used by experimenters in justification of the data adjustment are discussed. It is concluded that the evidence from all Bell experiments is in urgent need of re-assessment, in the light of all the known ``loopholes''. Invalid Bell tests have frequently been used, neglecting an improved one derived by Clauser and Horne in 1974. ``Local causal'' explanations for the observations have been wrongfully neglected.

  6. A national survey (NAP5-Ireland baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in Ireland.

    Jonker, W R

    2014-06-29

    As part of the 5th National Audit Project of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland concerning accidental awareness during general anaesthesia, we issued a questionnaire to every consultant anaesthetist in each of 46 public hospitals in Ireland, represented by 41 local co-ordinators. The survey ascertained the number of new cases of accidental awareness becoming known to them for patients under their care or supervision for a calendar year, as well as their career experience. Consultants from all hospitals responded, with an individual response rate of 87% (299 anaesthetists). There were eight new cases of accidental awareness that became known to consultants in 2011; an estimated incidence of 1:23 366. Two out of the eight cases (25%) occurred at or after induction of anaesthesia, but before surgery; four cases (50%) occurred during surgery; and two cases (25%) occurred after surgery was complete, but before full emergence. Four cases were associated with pain or distress (50%), one after an experience at induction and three after experiences during surgery. There were no formal complaints or legal actions that arose in 2011 related to awareness. Depth of anaesthesia monitoring was reported to be available in 33 (80%) departments, and was used by 184 consultants (62%), 18 (6%) routinely. None of the 46 hospitals had a policy to prevent or manage awareness. Similar to the results of a larger survey in the UK, the disparity between the incidence of awareness as known to anaesthetists and that reported in trials warrants explanation. Compared with UK practice, there appears to be greater use of depth of anaesthesia monitoring in Ireland, although this is still infrequent.

  7. International Olympic Committee consensus statement: harassment and abuse (non-accidental violence) in sport.

    Mountjoy, Margo; Brackenridge, Celia; Arrington, Malia; Blauwet, Cheri; Carska-Sheppard, Andrea; Fasting, Kari; Kirby, Sandra; Leahy, Trisha; Marks, Saul; Martin, Kathy; Starr, Katherine; Tiivas, Anne; Budgett, Richard

    2016-09-01

    Despite the well-recognised benefits of sport, there are also negative influences on athlete health, well-being and integrity caused by non-accidental violence through harassment and abuse. All athletes have a right to engage in 'safe sport', defined as an athletic environment that is respectful, equitable and free from all forms of non-accidental violence to athletes. Yet, these issues represent a blind spot for many sport organisations through fear of reputational damage, ignorance, silence or collusion. This consensus statement extends the 2007 IOC Consensus Statement on Sexual Harassment and Abuse in Sport, presenting additional evidence of several other types of harassment and abuse-psychological, physical and neglect. All ages and types of athletes are susceptible to these problems but science confirms that elite, disabled, child and lesbian/gay/bisexual/trans-sexual (LGBT) athletes are at highest risk, that psychological abuse is at the core of all other forms and that athletes can also be perpetrators. Harassment and abuse arise from prejudices expressed through power differences. Perpetrators use a range of interpersonal mechanisms including contact, non-contact/verbal, cyber-based, negligence, bullying and hazing. Attention is paid to the particular risks facing child athletes, athletes with a disability and LGBT athletes. Impacts on the individual athlete and the organisation are discussed. Sport stakeholders are encouraged to consider the wider social parameters of these issues, including cultures of secrecy and deference that too often facilitate abuse, rather than focusing simply on psychopathological causes. The promotion of safe sport is an urgent task and part of the broader international imperative for good governance in sport. A systematic multiagency approach to prevention is most effective, involving athletes, entourage members, sport managers, medical and therapeutic practitioners, educators and criminal justice agencies. Structural and

  8. Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells.

    Tesoriere, L; Attanzio, A; Allegra, M; Gentile, C; Livrea, M A

    2014-02-01

    Dietary redox-active/antioxidant phytochemicals may help control or mitigate the inflammatory response in chronic inflammatory bowel disease (IBD). In the present study, the anti-inflammatory activity of indicaxanthin (Ind), a pigment from the edible fruit of cactus pear (Opuntia ficus-indica, L.), was shown in an IBD model consisting of a human intestinal epithelial cell line (Caco-2 cells) stimulated by IL-1β, a cytokine known to play a major role in the initiation and amplification of inflammatory activity in IBD. The exposure of Caco-2 cells to IL-1β brought about the activation of NADPH oxidase (NOX-1) and the generation of reactive oxygen species (ROS) to activate intracellular signalling leading to the activation of NF-κB, with the over-expression of inflammatory enzymes and release of pro-inflammatory mediators. The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 μM), and IL-1β prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner. The co-incubation of the cells with Ind and IL-1β also prevented the IL-1β-induced increase of epithelial permeability. It was also shown that the activation of NOX-1 and NF-κB was prevented by Ind and the expression of COX-2 and inducible NO synthase was reduced. The uptake of Ind in Caco-2 cell monolayers appeared to be unaffected by the inflamed state of the cells. In conclusion, our findings suggest that the dietary pigment Ind may have the potential to modulate inflammatory processes at the intestinal level.

  9. Accidental nuclear excursion recuplex operation 234-5 facility: Final medical report

    Fuqua, P. A.

    1962-04-07

    The April 7, 1962 criticality accident involving human exposures was the first to have occurred in any production facility at Hanford. The accidental nuclear excursion did not result in any mechanical damage or spread of contamination. Three employees received over-exposure to gamma and neutron radiation. None were fatally exposed and in each case the over-exposure was recognized promptly. Following an initial period of medical observation and testing, the men were released to work. They continued to be followed clinically. Clinical studies performed were hematological procedures including leukocyte chromosome aberrations, morphologically aberrant blood cells, bone marrow evaluations, blood chemistry determinations, amino acid excretion studies, seminal fluid, urinary gonadotropins and estrogen excretion studies, testicular biopsies and crystalline lens examinations. These studies, along with a brief description of the accident and of the dosimetry, are summarized in this report by those participating in the studies. In view of the dose ranges received in these cases, both the negative and positive findings are considered to be of unusual interest due to the lack of knowledge of effects following human exposures at these levels.

  10. Ovarian hyperstimulation syndrome prevention strategies: oral contraceptive pills-dual gonadotropin-releasing hormone agonist suppression with step-down gonadotropin protocols.

    Damario, Mark A

    2010-11-01

    The identification of patients at high risk for excessive responses to ovarian stimulation for in vitro fertilization and embryo transfer is essential in the tailoring of safe and effective treatment strategies. Known factors associated with increased sensitivity to gonadotropins include polycystic ovary syndrome, young age, prior ovarian hyperstimulation syndrome (OHSS), high baseline antral follicle count, and high baseline ovarian volume. Although several treatment strategies have been proposed for these patients, this report describes the experience using the dual suppression with gonadotropin step-down protocol. This protocol uses oral contraceptive pretreatment in combination with a long gonadotropin-releasing hormone agonist followed by a programmed step-down in gonadotropin dosing. Hormonal characteristics of dual suppression include an improved luteinizing hormone-to-follicle-stimulating hormone ratio and lower serum androgens, particularly dehydroepiandrosterone sulfate. Clinical characteristics of the protocol include a lower cancellation rate and favorable clinical and ongoing pregnancy rates per initiated cycle while mitigating the risk of OHSS.

  11. FACTORES DE RIESGO QUE OCASIONAN ACCIDENTES LABORALES EN EL PERSONAL DE ENFERMERÍA DE UNA CLÍNICA ACREDITADA DE LA CIUDAD DE AREQUIPA, 2007-2008

    GARCIA SUTTA, PATRICIA CONCEPCION

    2014-01-01

    FACTORES DE RIESGO CONCEPTUALIZACIÓN TIPOS RIESGOS NO MECÁNICOS RUIDOS RADIACIONES IONIZANTES ILUMINACIÓN CALOR FRÍO RIESGOS FÍSICOS MECÁNICOS RIESGOS QUÍMICOS RIESGOS ERGONÓMICOS POSTURA RIESGOS BIOLÓGICOS CARGA DE TRABAJO LABORAL DEFINICIÓN ACCIDENTES LABORALES ACCIDENTE CAUSAS BÁSICAS Y CAUSAS INMEDIATAS ACCIDENTES LABORALES CAUSAS DE LOS ACCIDENTES TIPOS DE ACCIDENTE TIPOS DE ACCIDENTES LABORALES

  12. Prevention IS Care

    2009-03-26

    This podcast provides an overview of the Prevention IS Care campaign, which provides HIV prevention tools for medical care providers to use on a daily basis with patients who are living with HIV.  Created: 3/26/2009 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/26/2009.

  13. Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice.

    Yuan, Li; Han, Xiao; Li, Wenfeng; Ren, Daoyuan; Yang, Xingbin

    2016-04-06

    Isoorientin (ISO), a natural flavonoid, has been found to have multiple biological properties. In the present study, obese mice with high-fructose (HF)-induced liver injury were used to investigate the hepatoprotective effects of ISO. The results showed that ISO significantly reduced the serum lipid parameters in mice fed 20% HF water. Meanwhile, ISO appeared to alleviate HF-induced lipid metabolic disorders by increasing the serum levels of apo-A1 and decreasing the serum apoB levels, apoB/apo-A1 ratio, and FAS activity in the liver. ISO also remarkably ameliorated HF-induced hepatic oxidative injury and inflammation by decreasing ALT, AST, and ALP levels; enhancing antioxidant enzyme activities; and inhibiting inflammatory cytokine (TNF-α, IL-1, IL-6) release. Histopathology of liver stained by H&E and Oil Red O showed the liver steatosis and oxidative injury after HF treatment and the protective effect of ISO. Furthermore, aortic pathology observation found that ISO had a protective effect on the vascular endothelium. This is the first report that ISO efficiently inhibited HF-induced hyperlipidemia and liver injury by ameliorating lipid metabolism, enhancing the antioxidant defensedefense system, and regulating the secretion of inflammatory cytokines.

  14. Accidental Children Poisoning With Methadone: An Iranian Pediatric Sectional Study

    Sayena JABBEHDARI

    2013-11-01

    Full Text Available How to Cite This Article: Jabbehdari S, Farnaghi F, Shariatmadari SF, Jafari J, Mehregan FF, Karimzadeh P. Accidental Children Poisoning With Methadone: An Iranian Pediatric Sectional Study. Iran J Child Neurol. 2013 Autumn;7(7: 32-34.ObjectiveToxic poisoning with methadone is common in children in Iran. Our study was carried out due to the changing pattern of methadone poisoning in recent years and increasing methadone toxicity. Materials & MethodsIn this descriptive-sectional study, all of the methadone poisoned children younger than 12 years who were admitted to the Loghman Hakim Hospital in 2012, were assessed. Clinical symptoms and signs, para-clinical findings, and treatment were evaluated. ResultsIn this study, 16 boys and 15 girls who had been poisoned by methadone were enrolled. The mean age of patients was 55 months. All patients had been poisoned randomly or due to parent’s mistakes. The mean time of symptoms onset after methadone consumption was 1 hour and 30 Min, indicating a relatively long time after onset of symptoms.Clinical findings were drowsiness (75%, miotic pupil (68 %, vomiting (61%, rapid shallow breathing (57% and apnea (40%. In paraclinical tests, respiratory acidosis (69% and leukocytosis (55.2% were seen. The most important finding was increase in distance of QT in ECG (23.8%. The mean time of treatment with naloxone infusion was 51 hours. Three percent of patients had a return of symptoms after discontinuation of methadone. In patients with apnea, a longer course of treatment was required, and this difference was significant. Also, 17% of patients with apnea had aspiration pneumonia, which was statistically significant. ConclusionWe suggest long time treatment with naloxone and considering the probability of return of symptoms after discontinuation of methadone.ReferencesGoldfrank L, Flomenbaum N, Lewin N. Goldfrank’s Toxicologic Emergencies. 7th ed. McGraw–Hill 2002; p. 590-607.Schelble DT. Phosgene and

  15. Accidental intoxication of the infant-juvenile population in households: profiles of emergency care

    Jackeline Gonçalves Brito

    2015-06-01

    Full Text Available OBJECTIVE Analyzing profiles of intoxication and accidental poisoning of infant-juvenile population (0-24 years in the household, treated at a reference facility for Emergency and Primary Care, during the year 2013. METHOD A descriptive, cross-sectional study. Data were analyzed using Epi-Info, by way of simple and bivariate analyzes. The project was approved by the Research Ethics Committee (protocol 405.578. RESULTS There were 45 intoxications, with a prevalence of males (60.0%, aged 1-4 years (71.1%. Among children under one, there was a higher frequency of pesticide poisoning (66.6%, between the ages of 1-4 by cleaning products (34.4%, and between 5-9 years of age by pharmacological substances (66.6%. The primary assistance was provided only at health institutions, with hospital admissions in 24.4% of the cases. CONCLUSION The importance of prevention through legislation is evident, in order to ensure greater safety in packaging of various products, and community awareness to eliminate risks in the household environment.

  16. Clinical and ethical orientations in case of accidental ingestion of foreign body during dental treatment

    Rhonan Ferreira da Silva

    2010-07-01

    Full Text Available Introduction:The passage of foreign bodies through the oropharynx during dental treatment is an accident that can be avoided in most cases,especially when the dentist adopts preventive measures such as using rubber dam or tying certain objects with dental floss. Objective:To emphasize the importance of avoiding the accident of ingesting foreign bodies during dental treatment and to guide the dentist on how to proceed,clinically and ethically, if the accident occurs.Case report:A minor female patient, unaccompanied,accidentally ingested a bur used for finishing a composite resin restoration during a dental treatment performed in the public service, due to a defect in the high-speed handpiece.The patient and their parents were informed of the accident,and the object was monitored radiographically until its elimination by natural means,with no reports of discomfort.Conclusion:It is the responsibility of the dentist to know and follow the necessary measures to avoid or solve complications from ingesting foreign bodies, since patient’s health and integrity must be protected. In addition, the dentist will also avoid possible ethical and legal demands when fulfilling his responsibilities as a health care professional.

  17. La prevención de accidentes (2

    Chinchilla, M.

    1966-03-01

    Full Text Available Everyone prefers to work in those organizations where their dignity of human beings is respected. One of the most efficient means at the disposal of any firm, to improve the morale of the individual employees, and to establish a spirit of cooperation between the individual and the firm, is to set up a program of accident benefit. It will avoid direct and indirect losses due to working accidents, as analyzed in a previous article, and it will make it possible to improve total performance of each worker, since he will work in a more favorable environment, free from worry about potential danger to his person. It is almost impossible to describe in detail all those items that should be taken into account in a safety program. None the less, and as an indication of their diversity, some sources of danger are mentioned in this chapter, which are closely connected with human safety, such as public curiosity, travelling from one place to another, cleanliness and order.Todas las personas prefieren desempeñar sus tareas en aquellas organizaciones que tienen hacia ellos las consideraciones correspondientes a un ser humano. Uno de los medios más eficaces a disposición de cualquier empresa para elevar la moral del individuo y para crear un lazo de cooperación común entre el individuo y la empresa, es la de llevar a cabo un programa de prevención de accidentes, programa que redundará en el doble fruto: evitar las pérdidas directas e indirectas causadas por los accidentes de trabajo que se detallaron en un trabajo anterior, y conseguir aumentar el rendimiento del operario al hacerle un ambiente más grato por la preocupación que se demuestra hacia su persona. Es casi imposible detallar todos aquellos puntos que se deben tener en cuenta en un programa de seguridad; sin embargo, y como exponente de su diversidad, se señalan en este capítulo algunas causas, que, sin estar ligadas directamente con el trabajo individual, no obstante se encuentran

  18. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial

    Diener, Hans-Christoph; Sacco, Ralph L; Yusuf, Salim;

    2008-01-01

    -DP) twice a day or 75 mg clopidogrel once a day, and either 80 mg telmisartan or placebo once per day. The predefined endpoints for this substudy were disability after a recurrent stroke, assessed with the modified Rankin scale (mRS) and Barthel index at 3 months, and cognitive function, assessed......BACKGROUND: The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist...... telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial. METHODS: Patients who had had an ischaemic stroke were randomly assigned in a two by two factorial design to receive either 25 mg aspirin (ASA) and 200 mg extended-release dipyridamole (ER...

  19. Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain

    Lyons, Anthony

    2011-03-31

    Abstract Background Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible factor which may contribute is interferon-γ (IFNγ). IFNγ has been shown to increase in the aged brain and potently activates microglia, although its endogenous cell source in the brain remains unidentified. Methods Male Wistar rats were used to assess the effect of age and amyloid-β (Aβ) on NK cell infiltration into the brain. The effect of the anti-inflammatory compound, atorvastatin was also assessed under these conditions. We measured cytokine and chemokine (IFNγ, IL-2, monocyte chemoattractant protein-1 (MCP-1) and IFNγ-induced protein 10 kDa (IP-10)), expression in the brain by appropriate methods. We also looked at NK cell markers, CD161, NKp30 and NKp46 using flow cytometry and western blot. Results Natural killer (NK) cells are a major source of IFNγ in the periphery and here we report the presence of CD161+ NKp30+ cells and expression of CD161 and NKp46 in the brain of aged and Aβ-treated rats. Furthermore, we demonstrate that isolated CD161+ cells respond to interleukin-2 (IL-2) by releasing IFNγ. Atorvastatin, the HMG-CoA reductase inhibitor, attenuates the increase in CD161 and NKp46 observed in hippocampus of aged and Aβ-treated rats. This was paralleled by a decrease in IFNγ, markers of microglial activation and the chemokines, MCP-1 and IP-10 which are chemotactic for NK cells. Conclusions We propose that NK cells contribute to the age-related and Aβ-induced neuroinflammatory changes and demonstrate that these changes can be modulated by atorvastatin treatment.

  20. Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain

    Clarke Rachael

    2011-03-01

    Full Text Available Abstract Background Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible factor which may contribute is interferon-γ (IFNγ. IFNγ has been shown to increase in the aged brain and potently activates microglia, although its endogenous cell source in the brain remains unidentified. Methods Male Wistar rats were used to assess the effect of age and amyloid-β (Aβ on NK cell infiltration into the brain. The effect of the anti-inflammatory compound, atorvastatin was also assessed under these conditions. We measured cytokine and chemokine (IFNγ, IL-2, monocyte chemoattractant protein-1 (MCP-1 and IFNγ-induced protein 10 kDa (IP-10, expression in the brain by appropriate methods. We also looked at NK cell markers, CD161, NKp30 and NKp46 using flow cytometry and western blot. Results Natural killer (NK cells are a major source of IFNγ in the periphery and here we report the presence of CD161+ NKp30+ cells and expression of CD161 and NKp46 in the brain of aged and Aβ-treated rats. Furthermore, we demonstrate that isolated CD161+ cells respond to interleukin-2 (IL-2 by releasing IFNγ. Atorvastatin, the HMG-CoA reductase inhibitor, attenuates the increase in CD161 and NKp46 observed in hippocampus of aged and Aβ-treated rats. This was paralleled by a decrease in IFNγ, markers of microglial activation and the chemokines, MCP-1 and IP-10 which are chemotactic for NK cells. Conclusions We propose that NK cells contribute to the age-related and Aβ-induced neuroinflammatory changes and demonstrate that these changes can be modulated by atorvastatin treatment.

  1. Relocation impacts of a major release from SRTC

    Blanchard, A.; Thompson, E.A.; Thompson, J.M.

    1999-06-01

    The relocation impacts of an accidental release, scenario 1-RD-3 , are evaluated for the Savannah River Technology Center. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide(PAG)is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the particulate portion of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet. The consequences of the tritium release are evaluated using UFOTRI.

  2. Calidad de vida de cuidadores de adultos con accidente cerebrovascular

    INNA ELIDA FLÓREZ TORRES

    2010-10-01

    Full Text Available Objetivo: describir la calidad de vida de los cuidadores familiares de adultos con secuelas de accidente cerebrovascular, en Cartagena, Colombia. Método: estudio descriptivo cuantitativo realizado durante el segundo semestre de 2008. Muestra no probabilística por conveniencia de 97 cuidadores. Se empleó el instrumento propuesto por Ferrell et ál. Para valorar cada uno de los bienestares que integran la calidad de vida se utilizaron medidas de tendencia central y coeficiente de variación. Resultados: el grupo de cuidadores presentó en el bienestar físico un promedio de 11,1 con relación al máximo puntaje, lo que indica el peor estado de salud; los bienestares psicológico y social tuvieron promedios de 48,8 y 21,9, respectivamente, con menor afectación. El mejor estado se halló en el bienestar espiritual, con promedio de 22,6. Conclusiones: la experiencia de ser cuidador modifica de manera importante la calidad de vida de las personas; los cuidadores, como fuente importante de cuidado informal, requieren apoyo de los sistemas de salud y, como parte de este, de los profesionales de enfermería.

  3. [Gonococcal vulvovaginitis in prepubertal girls: sexual abuse or accidental transmission?].

    Daval-Cote, M; Liberas, S; Tristan, A; Vandenesch, F; Gillet, Y

    2013-01-01

    Vulvovaginitis is the most frequent gynecologic pathology among prepubertal females. An infectious cause is found in 30% of cases and is highly associated with the presence of vaginal discharge upon examination. Neisseria gonorrhoeae may be one of the causative agents. Since N. gonorrhoeae is a common sexually transmitted disease, sexual abuse should be considered in the pediatric setting. We report the case of a 5-year-old girl with N. gonorrhoeae vulvovaginitis. Her previous history, multiple interviews with the patient and her parents, and clinical examination showed no evidence or signs of sexual abuse. Both parents presented gonorrhea, urethritis for the father and vaginitis for the mother. The discrepancy between pediatric evaluation and the presence of a bacterium associated with sexually transmitted disease led us to consider other means of contamination. Previous studies have shown that other routes of transmission are possible but are often neglected. Hence, contamination can be transmitted by the hands or mostly through passive means (towels, rectal thermometer, etc.). Many epidemics have been noted in group settings with young girls with no evidence of sexual transmission. Therefore, we concluded that this patient's infection was likely an accidental transmission within her family. The acknowledgement of these transmission routes is very important in order to avoid misguided suspicion of sexual abuse and the possible traumatic family and psychosocial consequences.

  4. Lead excretion in milk of accidentally exposed dairy cattle.

    Bischoff, Karyn; Higgins, William; Thompson, Belinda; Ebel, Joseph G

    2014-01-01

    Lead (Pb) exposure in dairy cattle is associated with economic losses due to mortality and treatment costs, but with production animals there is also risk to the human food chain. The first objective of this study was to quantify the Pb concentration in milk from Pb-exposed cattle. The second objective was to correlate blood and milk Pb concentrations from individual cows. The third objective was long-term monitoring to determine the duration of milk contamination after exposure ceased. A dairy herd of more than 100 cows was accidentally exposed to Pb-contaminated feed. Milk and blood were collected for Pb analysis. Serial collection of milk samples continued for 2.5 years. The initial concentration of Pb in bulk tank milk was 0.0999 mg l⁻¹. The highest milk Pb concentration from an individual cow was 0.4657 mg l⁻¹ and the highest blood Pb concentration was 1.216 mg l⁻¹. One milk sample collected at the end of the study (day 922) contained 0.0117 mg Pb l⁻¹ of Pb. The calculated relationship between milk (y) and blood (x) Pb concentration was ln(y) = 3.4(x) - 2.21 (R² = 0.98).

  5. High mortality due to accidental salinomycin intoxication in sheep

    Ashrafihelan Javad

    2014-09-01

    Full Text Available In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran had been added to the ration (22388 mg/kg = 22388 ppm and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed.

  6. Accidental intoxication with hydrochloric acid and hydrofluoric acid mixture.

    Smędra-Kaźmirska, A; Kędzierski, M; Barzdo, M; Jurczyk, Ap; Szram, S; Berent, J

    2014-01-01

    The paper describes a fatal case of accidental ingestion of a mixture of hydrochloric acid and hydrofluoric acid. The man was admitted to hospital, where appropriate treatment, adequate to his condition, was instituted. Numerous ventricular fibrillation episodes, for which the patient was defibrillated repeatedly, were observed during the period of hospitalization. The patient was in a critical condition, with progressive symptoms of hypovolemic shock and multiorgan failure. On the next day after admission, signs of electromechanical dissociation progressing to asystole were noted. The instituted resuscitation procedure proved ineffective and the patient died. Autopsy revealed brownish discoloration of the esophageal, gastric, and small intestinal mucous membranes. Numerous ulcerations without signs of perforation were found both in the esophagus and in the stomach. The mucous membrane of the small intestine demonstrated focal rubefactions, whereas no focal lesions of the large intestinal mucosa were seen. Microscopic investigation of the biopsy specimens collected from the stomach, duodenum and small intestine revealed mucous membrane necrosis foci, reaching the deeper layers of the wall of these organs. The mucous membrane of the large intestine was congested. Bioptates obtained from the lungs indicated the presence of hemorrhagic infarcts and focal extravasations. Poisoning with the aforementioned acids with consequent necrosis of the esophageal, gastric, duodenal and small intestinal walls with hemorrhages to the gastrointestinal tract, as well as extravasations and hemorrhagic infarcts in the lungs was considered to be the cause of death.

  7. Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

    Maria Ballesta Méndez

    2014-01-01

    Full Text Available Background. 4-Aminopyridine (4-AP is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS. Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation. A 58-year-old woman with progressive MS presented with status epilepticus. She was receiving 4-AP for more than 3 years. The symptoms started soon after the ingestion of a single pill that was supposed to contain 10 mg 4-AP, but further investigations revealed that each pill had been inadvertently prepared with an 100 mg 4-AP concentration. The patient was admitted to the intensive care unit (ICU for appropriate management (orotracheal intubation, sedation, and antiepileptic drugs. The first electroencephalogram (EEG showed abundant irregular spike-waves on the left central regions. Neurological condition gradually improved from day 7, while the EEG did not reveal any more electrical seizures but was still consistent with toxic encephalopathy. The patient stayed in the ICU until day 13. At discharge from the rehabilitation ward (2.5 months later, the patient had not yet recovered her previous cognitive and functional condition. Conclusion. A single 100 mg 4-AP accidental overdose may cause serious immediate complications, with a slow and incomplete neurological recovery.

  8. ¿Accidente industrial o amputación deliberada?

    Ponce, Paola

    2005-01-01

    Full Text Available El objetivo de este trabajo es analizar los diferentes aspectos de la práctica de amputaciones durante el período victoriano de Inglaterra tales como: las causas que llevaron a tal práctica, los métodos y técnicas quirúrgicos usados durante el S. XIX así como la evidencia de atrofia y/o asimetría por causa del desuso. Tres casos de amputaciones fueron encontrados en una población industrial en el cementerio Victoriano de St. Pete s Collegiate Church en Wolverhampton (West Midlands, Inglaterra. Las amputaciones fueron realizadas en el miembro superior de una mujer (HB53 y los miembros inferiores de dos hombres (HB86 y (HB129. Se concluye que en los tres casos los individuos sobrevivieron a las amputaciones y que estas fueron realizadas mucho tiempo antes de la muerte. Dos de ellas fueron probablemente realizadas mediante cirugía (HB86 y HB129 mientras que la tercera (HB53 podría ser el resultado de un accidente industrial.

  9. Accidental Cutaneous Burns Secondary to Salbutamol Metered Dose Inhaler

    Ashutosh Kale

    2010-01-01

    Full Text Available We report a case of accidental cutaneous burns caused by salbutamol metered dose inhaler. A 9-year-old boy underwent dental extraction at a children's hospital and was incidentally noted to have burn injuries on dorsum of both hands. On questioning, the boy revealed that a few days ago his 14-year-old brother, who is an asthmatic, playfully sprayed his salbutamol metered dose inhaler on the back of both his hands with the inhaler's mouth piece being in direct contact with the patient's skin. On examination, there was a rectangular area of erythema with superficial peeling on the dorsum of both hands, the dimensions of which exactly matched those of the inhaler's mouthpiece. It is possible that the injury could have been a chemical burn from the pharmaceutical/preservative/propellant aerosol or due to the physical effect of severe cooling of the skin or mechanical abrasive effect of the aerosol blasts or a combination of some or all the above mechanisms. This case highlights the importance of informing children and parents of the potentially hazardous consequences of misusing a metered dose inhaler.

  10. Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation

    Yan Wang; Liqing Du; Chang Xu; Qin Wang; Zhiyi Song; Jianxiang Liu; Xu Su

    2016-01-01

    Biomarkers,such as chromosome aberration and micronuclei assays,prove to be reliable for facilitating clinical diagnosis in radiation accidents.In a radiation accident in India,chromosomal aberration,γ-H2AX,as well as other blood markers,were detected in accidentally exposed victims.This multi-parametric approach aided in confirming that individuals had been exposed by ionizing radiation.However,doses were impossible to estimate because of a 30-day delay in accident awareness.Exposure dose for victims was estimated using a dose-response curve previously established.Dose estimation,blood cell depletion kinetics,and no appearance of prodromal symptoms suggested that doses of exposure were low.Hematologic investigation,sampling time,and chromosome aberration scoring were all proposed according to data from the victims exposed to 60Co.Finally,knowledge regarding chromosome aberration analysis and the importance of international co-operation and assistance should be shared from this accident.

  11. Pre-accidental situations highlighted by RECUPERARE method and data

    Matahri, N. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France)

    2006-07-01

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  12. Funciones superiores en pacientes con accidente cerebro vascular.

    Felipe Rodríguez

    2009-07-01

    Full Text Available Los estudios realizados en Chile hasta la fecha no permiten detectar de manera significativa el deterioro neuropsicológico causado por el accidente cerebro vascular (ACV y el impacto que éste tiene en el paciente a nivel de su desenvolvimiento diario y familiar. Con base a esto el objetivo de esta investigación fue elaborar un perfil de deterioro neuropsicológico de las diversas funciones cerebrales superiores causado por un ACV, en un grupo de 50 pacientes de la Unidad de Medicina Física del Hospital San José al cuál se le administró un Protocolo de Evaluación Neuropsicológica, comparándose luego con un grupo control de 50 sujetos evaluados con el mismo protocolo. Se encuentra que sobre un 20% de la población con ACV evaluada presenta deterioro en al menos uno de los ítems evaluados, siendo las funciones ejecutivas, la memoria a largo plazo y la memoria a corto plazo las áreas mayoritariamente afectada en la población evaluada.

  13. Accidental intoxication with hydrochloric acid and hydrofluoric acid mixture

    Anna Smędra-Kaźmirska

    2014-08-01

    Full Text Available The paper describes a fatal case of accidental ingestion of a mixture of hydrochloric acid and hydrofluoric acid. The man was admitted to hospital, where appropriate treatment, adequate to his condition, was instituted. Numerous ventricular fibrillation episodes, for which the patient was defibrillated repeatedly, were observed during the period of hospitalization. The patient was in a critical condition, with progressive symptoms of hypovolemic shock and multiorgan failure. On the next day after admission, signs of electromechanical dissociation progressing to asystole were noted. The instituted resuscitation procedure proved ineffective and the patient died. Autopsy revealed brownish discoloration of the esophageal, gastric, and small intestinal mucous membranes. Numerous ulcerations without signs of perforation were found both in the esophagus and in the stomach. The mucous membrane of the small intestine demonstrated focal rubefactions, whereas no focal lesions of the large intestinal mucosa were seen. Microscopic investigation of the biopsy specimens collected from the stomach, duodenum and small intestine revealed mucous membrane necrosis foci, reaching the deeper layers of the wall of these organs. The mucous membrane of the large intestine was congested. Bioptates obtained from the lungs indicated the presence of hemorrhagic infarcts and focal extravasations. Poisoning with the aforementioned acids with consequent necrosis of the esophageal, gastric, duodenal and small intestinal walls with hemorrhages to the gastrointestinal tract, as well as extravasations and hemorrhagic infarcts in the lungs was considered to be the cause of death.

  14. Accidental blood exposures among medical residents in Paris, France.

    Mir, O; Adam, J; Veyrie, N; Chousterman, B; Gaillard, R; Gregory, T; Yordanov, Y; Berveiller, P; Loulergue, P

    2011-03-01

    Accidental blood exposure (ABE) exposes healthcare workers, including medical residents, to the risk of occupational infection. We aimed to determine the characteristics of ABEs in residents with an anonymous self-reporting electronic questionnaire. A total of 350 residents (33% from surgical disciplines) entered this survey. One hundred and eighty-five residents (52%) reported at least one ABE during their residency (median, 2; range, 1-25), 53% of which occurred in operating theatres. Sixty-nine per cent of residents followed the current procedures for local disinfection. ABEs were notified to the hospital administration by 62% of residents, but only 51% of residents were referred to the occupational medicine department. The most frequently reported concerns following ABEs were human immunodeficiency virus (52%) and hepatitis C virus infection (39%). In 74% of cases, the serological status of the index patient was investigated. Only 54% of residents were aware of their hepatitis B surface antibody titres. Medical residents behaved inappropriately in 33% of cases in this survey. Further educational programmes should include residents, and not only senior healthcare workers, in order to improve individual behaviours.

  15. Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release.

    Lisa B Davidson

    Full Text Available Mycobacterium abscessus has emerged as an important cause of lung infection, particularly in patients with bronchiectasis. Innate immune responses must be highly effective at preventing infection with M. abscessus because it is a ubiquitous environmental saprophyte and normal hosts are not commonly infected. M. abscessus exists as either a glycopeptidolipid (GPL expressing variant (smooth phenotype in which GPL masks underlying bioactive cell wall lipids, or as a variant lacking GPL which is immunostimulatory and invasive in macrophage infection models. Respiratory epithelium has been increasingly recognized as playing an important role in the innate immune response to pulmonary pathogens. Respiratory epithelial cells express toll-like receptors (TLRs which mediate the innate immune response to pulmonary pathogens. Both interleukin-8 (IL-8 and human β-defensin 2 (HβD2 are expressed by respiratory epithelial cells in response to toll-like receptor 2 (TLR2 receptor stimulation. In this study, we demonstrate that respiratory epithelial cells respond to M. abscessus variants lacking GPL with expression of IL-8 and HβD2. Furthermore, we demonstrate that this interaction is mediated through TLR2. Conversely, M. abscessus expressing GPL does not stimulate expression of IL-8 or HβD2 by respiratory epithelial cells which is consistent with "masking" of underlying bioactive cell wall lipids by GPL. Because GPL-expressing smooth variants are the predominant phenotype existing in the environment, this provides an explanation whereby initial M. abscessus colonization of abnormal lung airways escapes detection by the innate immune system.

  16. Commitment of involved actors in the preparation of accidental and post-accident situations: European experiments; Engagement des parties prenantes a la preparation aux situations accidentelles et post-accidentelles: experiences Europeennes

    Schneider, Th. [CEPN, 28 rue de la Redoute, 92260 Fontenay-aux-Roses (France)

    2010-07-01

    The author briefly describes some approaches developed within the EURANOS European research programme between 2004 and 2009 which aims at promoting the building up of a European network (NERIS) for the management of nuclear accidental and post-accident situations. Notably, he comments the experiment which took place in the Montbeliard district where two types of radiological events have been modelled and simulated: an accident in the Fessenheim nuclear power plant with two scenarios of release, and a transportation accident with a release of radioactive caesium 137. He also evokes the Norwegian experience and some other actions in Finland, Great-Britain, Spain and Slovakia where reflections on the management of accidental and post-accident situations or crisis exercises have been organized

  17. A clinical study on prevention of median nerve injury in endoscopic carpal tunnel release%腕管综合征内窥镜手术预防正中神经损伤的临床研究

    姜晓琪; 陈臣; 叶作舟; 王斌; 史其林

    2011-01-01

    目的 介绍腕管综合征内窥镜手术(endoscopic carpal tunnel release,ECTR)预防正中神经损伤并发症的方法.方法 利用彩色多普勒超声仪(B超)对37例74手患者术前进行检测.结果 71例正中神经走行在桡侧腕屈肌腱与掌长肌腱之间,3例走行在掌长肌腱与尺侧腕屈肌腱之间,并术中确认.结论 正中神经变异走行在掌长肌腱与尺侧腕屈肌腱之间是ECTR的禁忌证,B超能准确定位正中神经与掌长肌腱关系,避免内窥镜手术损伤正中神经,更具有简单、经济、方便可靠等优点.%Objective To introduce a method of preventing median never injury during endoscopic carpal tunnel release (ECTR). Methods Ultrasonography of both wrists was done to 37 patients of carpal tunnel syndrome who were going to undergo open release of the transverse carpal ligament. Structures in the carpal tunnel were visualized to guide surgical decision-making. Results Ultrasonography showed that median never lies between the tendon of flexor carpi radialis and palmaris longus in 71 patients and lies between the tendon of palmaris longus and flexor carpi ulnaris in 3 patients. These findings were confirmed during the surgeries. Conclusion It is a contraindication of ECTR if median never lies between palmaris longus and flexor carpi ulnaris. Ultrasonography can accurately reveal the relative position of median never to the palmaris longus tendon. Pre-operative ultrasonography of the wrist is a simple, inexpensive and convenient method to exclude these contraindications and thus prevent median never injuries in ECTR.

  18. Management options for accidental injection of epinephrine from an autoinjector: a case report

    Mathez Christian

    2009-06-01

    Full Text Available Abstract Introduction Epinephrine autoinjector devices are used with increasing frequency to treat severe anaphylactic reactions. Accidental injection, usually involving a finger, is a potential complication. Case presentation A physician in a Family Practice training program accidentally injected epinephrine into his left thumb while reading the operating instructions of an autoinjector (Epipen®. He developed swelling, pallor, and pain in the thumb. Treatment included topical nitroglycerin, oral vasodilators and warming of the thumb. As expected, none caused an immediate response; however, after 8 hours, the thumb was pink and warm. There was full recovery 2 months after the accident. We reviewed the treatment of accidental epinephrine injection, and found that the use of parenteral adrenergic alpha blocker phentolamine would have produced immediate recovery. Conclusions All health professionals concerned with the use of epinephrine autoinjectors should receive adequate instruction on their use. A regimen for management of accidental epinephrine injection, in particular the use of phentolamine, should be emphasized.

  19. Persistent Seroconversion after Accidental Eye Exposure to Calcifying Nanoparticles

    Ciftcioglu, Neva; Aho, Katja M.; McKay, David S.; Kajander, E. Olavi

    2007-01-01

    Biosafety of nanomaterials has attracted much attention recently. We report here a case where accidental human eye exposure to biogenic nanosized calcium phosphate in the form of calcifying nanoparticles (CNP) raised a strong IgG immune response against proteins carried by CNP. The antibody titer has persisted over ten years at the high level. The IgG was detected by ELISA using CNPs propagated in media containing bovine and human serum as antigen. The exposure incident occurred to a woman scientist (WS) at a research laboratory in Finland at 1993. CNP, also termed "nanobacteria", is a unique self-replicating agent that has not been fully characterized and no data on biohazards were available at that time. Before the accident, her serum samples were negative for both CNP antigen and anti-CNP antibody using specific ELISA tests (Nanobac Oy, Kuopio, Finland). The accident occurred while WS was harvesting CNP cultures. Due to a high pressure in pipetting, CNP pellet splashed into her right eye. Both eyes were immediately washed with water and saline. The following days there was irritation and redness in the right eye. These symptoms disappeared within two weeks without any treatment. Three months after the accident, blood and urine samples of WS were tested for CNP cultures (2), CNP-specific ELISA tests, and blood cell counts. Blood cell counts were normal, CNP antigen and culture tests were negative. A high IgG anti-CNP antibody titer was detected (see Figure). The antibodies of this person have been used thereafter as positive control and standard in ELISA manufacturing (Nano-Sero IgG ELISA, Nanobac Oy, Kuopio, Finland).

  20. Intrathecal co-administration of ketamine and morphine preventing activation of astrocytes and decreasing releases of IL-1β and IL-6 from spinal cord in rats of morphine tolerance

    2005-01-01

    Objective: To investigate the effects of intrathecal administration of ketamine, a non-competitive N-methy-D-aspartate receptor antagonist, combined with morphine on the activation of astrocytes and releases of IL-1β and IL-6 from spinal cord in the rats of morphine tolerance. Methods: Twenty-seven Sprague-Dawley male rats were randomly divided into sham-operated, morphine tolerance, and morphine plus ketamine group. The subarachnoid catheterization of all the rats was prepared by the method of Jianping Yang.Morphine 20 μg in 10 μl was administrated intrathecally to induce spinal morphine tolerance once daily for 5 consecutive days. Morphine and ketamine 250 μg in 10 μl total volume was given in morphine plus ketamine group. Three groups all received intrathecal morphine 5 μg in 10 μl for morphine challenge test at 24 h after last administration of the morphine. After morphine challenge test, lumbar spinal tissues were taken for measurement of glial fibrillary acidic protein (GFAP) of astrocyte in lumbar spinal horn cord by immunohistochemistry and IL-1βand IL-6 of spinal cord by ELISA. Results: The decrease of %MPE induced by chronic intrathecal morphine was inhibited by ketamine and hyperalgesia and allodynia induced by morphine-withdrawl were alleviated. The average areas, the average absorbency (-A), the integral absorbency (A) of GFAP immuno-reactive cells in the dorsal horn, and IL-1β and IL-6 of spinal cord were significantly larger in morphine tolerance group than in morphine plus ketamine group. Conclusion: Co-administration of ketamine and morphine enhance antinociceptive effect of morphine and prevent the development of morphine tolerance. Ketamine might attenuate the activation of astrocytes and inhibit the release of IL-1β and IL-6 from spinal cord in repeated intrathecal morphine rats.

  1. Análisis de accidentes severos en contenciones nucleares

    Goicolea Ruigómez, José María

    1992-04-01

    Full Text Available Analysis for severe accidents has recently been added to the long list of requisites imposed on nuclear power plants. In this work we study the rationale and justiflcation for this type of analysis. Calculations for the structural response of the containment buildings can be performed on the computer using advanced nonlinear Finite Element codes. A state of the art review of these methods is carried out, proposing a methodology based on analysis by numerical methods with experimental validation. Additionally we present some results obtained by the authors for the analysis of both reinforced concrete and steel containments. The concluding remarks show the validity of the proposed methodology, as well as the evidence of a large security margin in the containments, due mainly to the conservatisms in the design stage.

    El análisis frente a accidentes severos ha venido a añadirse recientemente a la larga lista de requisitos impuestos a las centrales nucleares. En este trabajo se pretende estudiar la problemática y justificación de este tipo de análisis. El cálculo de la respuesta de la contención se puede realizar en el ordenador mediante métodos avanzados de elementos finitos no lineales. Se hace una revisión del estado de la técnica en estos métodos, proponiendo una metodología basada en el análisis mediante modelos numéricos con validación experimental. Se presentan asimismo los resultados de análisis realizados, para contenciones tanto de hormigón armado como metálicas. Las conclusiones del trabajo establecen la validez de la metodología empleada, así como la constatación de un amplio margen de seguridad existente en las contenciones evaluadas, debido a los conservadurismos del proceso de diseño original.

  2. Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

    Vilma Sousa Santana

    2013-01-01

    Full Text Available En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por causas externas, 31.576 (2,3% por accidentes de trabajo y solo 226 (0,02% por accidentes de trabajo con violen- cia interpersonal. Cerca del 80% de los informes estadísticos de defunción no tenían el campo “accidente de trabajo” completado. La mayor cantidad de casos ocurrió entre hom- bres (94,3% de 25-34 años, con nivel de escolaridad medio, ubicados en la región sudeste y noreste, que trabajan principalmente en la producción de bienes y servicios industriales y la actividad agropecuaria. La mayoría de los casos fueron causados por armas de fuego, seguidos por armas blancas, con un aumento relativo de estos últimos en el período estu- diado. Los resultados sugieren un gran subregistro de diagnósticos que reconocen la rela- ción con el trabajo. Se hace necesaria una mejor capacitación en el llenado de los informes estadísticos, así como estudios que cuantifiquen el subregistro de accidentes de trabajo y accidentes de trabajo con violencia interpersonal.

  3. Prevent Cervical Cancer!

    2015-01-08

    Cervical cancer can be prevented. Listen as two friends—one a doctor—talk about screening tests and early detection. Learn what test you might need.  Created: 1/8/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 1/8/2015.

  4. 75 FR 13215 - National Poison Prevention Week, 2010

    2010-03-19

    ...#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8484 of March 15, 2010 National Poison... National Poison Prevention Week we alert American families about the dangers of accidental poisonings and... million poison exposures reported each year, we must take every precaution to guard against...

  5. Ethical and Unethical Methods of Plagiarism Prevention in Academic Writing

    Bakhtiyari, Kaveh; Salehi, Hadi; Embi, Mohamed Amin; Shakiba, Masoud; Zavvari, Azam; Shahbazi-Moghadam, Masoomeh; Ebrahim, Nader Ale; Mohammadjafari, Marjan

    2014-01-01

    This paper discusses plagiarism origins, and the ethical solutions to prevent it. It also reviews some unethical approaches, which may be used to decrease the plagiarism rate in academic writings. We propose eight ethical techniques to avoid unconscious and accidental plagiarism in manuscripts without using online systems such as Turnitin and/or…

  6. Causes of accidental childhood deaths in China in 2010: A systematic review and analysis

    Kit Yee Chan

    2015-06-01

    Full Text Available Background Infectious causes of childhood deaths in the world have decreased substantially in the 21st century. This trend has exposed accidental deaths as an increasingly important future challenge. Presently, little is known about the cause structure of accidental childhood deaths in low– and middle–income country (LMIC settings In this paper, we aim to establish cause structure for accidental deaths in children aged 0–4 years in China in the year 2010. Methods In this paper, we explored the database of 208 multi–cause child mortality studies in Chinese that formed a basis for the first published estimate of the causes of child deaths in China (for the year 2008. Only five of those studies identified specific causes of accidental deaths. Because of this, we searched the Chinese medical literature databases CNKI and WanFang for single–cause mortality studies that were focused on accidental deaths. We identified 71 further studies that provided specific causes for accidental deaths. We used epidemiological modeling to estimate the number of accidental child deaths in China in 2010 and to assign those deaths to specific causes. Results In 2010, we estimated 314 581 deaths in children 0–4 years in China, of which 31 633 (10.1% were accidental. Accidental deaths contributed 7240 (4.0% of all deaths in neonatal period, 8838 (10.5% among all post–neonatal infant deaths, and 15 554 (31.7% among children with 1–4 years of age. Among four tested models, the most predictive was used to establish the likely cause structure of accidental deaths in China. We estimated that asphyxia caused 9490 (95% confidence interval (CI 8224–11 072, drowning 5694 (95% CI 5061–6327, traffic accidents 3796 (95% CI3163–4745, poisoning 3163 (95% CI 2531–3796 and falls 2531 (95% CI 2214–3163 deaths. Based on medians from a few rare studies, we also predict 633 (95% CI 316–1265 deaths to be due to burns and 316 (95% CI 0–633 due to falling objects

  7. Patterns and Trends in Accidental Poisoning Deaths: Pennsylvania's Experience 1979-2014.

    Lauren C Balmert

    Full Text Available The purpose of this study was to examine county and state-level accidental poisoning mortality trends in Pennsylvania from 1979 to 2014.Crude and age-adjusted death rates were formed for age group, race, sex, and county for accidental poisonings (ICD 10 codes X40-X49 from 1979 to 2014 for ages 15+ using the Mortality and Population Data System housed at the University of Pittsburgh. Rate ratios were calculated comparing rates from 1979 to 2014, overall and by sex, age group, and race. Joinpoint regression was used to detect statistically significant changes in trends of age-adjusted mortality rates.Rate ratios for accidental poisoning mortality in Pennsylvania increased more than 14-fold from 1979 to 2014. The largest rate ratios were among 35-44 year olds, females, and White adults. The highest accidental poisoning mortality rates were found in the counties of Southwestern Pennsylvania, those surrounding Philadelphia, and those in Northeast Pennsylvania near Scranton.The patterns and locations of accidental poisoning mortality by race, sex, and age group provide direction for interventions and policy makers. In particular, this study found the highest rate ratios in PA among females, whites, and the age group 35-44.

  8. Prevent Infections During Chemotherapy

    2011-10-24

    This podcast discusses the importance of preventing infections in cancer patients who are undergoing chemotherapy. Dr. Lisa Richardson, CDC oncologist, talks about a new Web site for cancer patients and their caregivers.  Created: 10/24/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 10/24/2011.

  9. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    Domingo García, AM

    2006-02-01

    Full Text Available RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas funcional, motriz, sensorial, perceptivo y cognitiva. No debemos olvidar el asesoramiento realizado al paciente, a la familia y/ o cuidadores sobre el manejo de la persona que ha sufrido un ictus, la adaptación del entorno y la prescripción, uso y manejo de ayudas técnicas cuando sea necesario.Las propuestas terapéuticas que expondré a continuación, no son recetas únicas que se puedan emplear del mismo modo en todos las personas que hayan sufrido un ictus. Con cada paciente será necesario una evaluación individualizada de su situación y una adaptación de la terapia según sus déficit específicos.La meta final de la Terapia Ocupacional es la integración óptima del paciente dentro de su entorno familiar y social, con el mayor grado de autonomía posible.ABSTRACTAmong the patients who need Occupational Therapy’s rehabilitation treatment, there are those who have suffered a cerebrovascular damage when elderly.People’s gradual ageing is one of the risk factors in the nervous central system’s alterations and this is why I am going to write about intervention on geriatric population.The Occupational Therapy’s rehabilitation treatment works on the functional, motor, sensorial, perceptive and cognitive areas. Moreover, we should not forget to advise the patient and his/her family or caregivers about the way of treating ,the environment’s adaptation, the prescription and use of technical aids when needed.The following therapeutic

  10. Surgical management of accidentally displaced mandibular third molar into the pterygomandibular space: a case report.

    Huang, I-Yueh; Chen, Chao-Ming; Chang, Sung-Wen; Yang, Chia-Fu; Chen, Chung-Ho; Chen, Chun-Min

    2007-07-01

    Surgical removal of the mandibular third molar is a regular surgical procedure in dental clinics, and like all operations, it may have some complications, such as infection, bleeding, nerve injuries, trismus and so on. An accidentally displaced lower third molar is a relatively rare complication, but may cause severe tissue injury and medicolegal problems. As few papers and cases have been published on this topic, we report this case to remind dentists on ways to prevent and manage this complication. The patient, a 28-year-old male, had his right lower mandibular third molar extraction in January 2006. The dentist resected the crown and attempted to remove the root but found that it had suddenly disappeared from the socket. Assuming that the root had been suctioned out he closed the wound. The patient was not followed up regularly because he studied abroad. About 3 months later, the patient felt a foreign body sensation over his right throat, and visited a local hospital in Australia. He was told after a computed tomography (CT) scan that there was a root-like radio-opaque image in the pterygomandibular space. The patient came to our hospital for further examination and management in June 2006. We rechecked with both Panorex and CT and confirmed the location of the displaced root. Surgery for retrieving the displaced root was performed under general anesthesia by conventional method without difficulty, and the wound healed uneventfully except for a temporary numbness of the right tongue. This case reminds us that the best way to prevent a displaced mandibular third molar is to evaluate the condition of the tooth carefully preoperatively, select adequate instruments and technique, and take good care during extraction. If an accident does occur, dentists should decide whether to retrieve it immediately by themselves or refer the case to an oral and maxillofacial surgeon, and should not try to remove the displaced root without proper assurance. Localization with

  11. Materiales didácticos para los contenidos de enfermedad y accidente en la etapa infantil

    Bocos Urdiales, Elías Javier

    2015-01-01

    Este trabajo, es una programación didáctica, que responde a la necesidad de crear materiales para la enseñanza dedicada a la actuación y prevención de accidentes y enfermedades tanto en lo personal, como en lo colectivo tanto en el aula como en los pasillos, patio y zonas comunes. En relación a los accidentes se realizaran materiales para la prevención de los accidentes en el ámbito del centro escolar; y además de la prevención daremos pautas de actuación a los alumnos de tal manera que se...

  12. 美国疾病控制与预防中心寨卡病毒病防控指南解读%Interpretation of the guidelines for prevention and control of lika virus disease released by American center for disease control and prevention

    宋宁; 郭宪立; 刘跃; 袁胜芳; 贾伟华

    2016-01-01

    Recently,United States Center for Disease Control and Prevention (CDC)released several guidelines for the evaluation and testing of Zika virus (ZIKV)in neonatal,infant,young children and pregnant women during a ZIKV outbreak,and published an interim guideline for the prevention of sexual transmission of ZIKV.This paper reviewed the current research progress of ZIKV and Zika virus disease (ZVD),and interpreted the CDC guidelines.The course covered biological characteristics,epidemic trends,clinical manifestations,route of transmission,laboratory examinations,diagnostic criteria,treatments and prevention protocols of ZIKV infection and ZVD in special population groups and etc,in order to improve the clinicians'understanding of ZIKV and ZVD.%近期美国疾病控制与预防中心(CDC)发布了针对寨卡病毒(ZIKV)流行期间新生儿、婴儿、青少年儿童、孕妇 ZIKV 感染的评估检测和防控指南,以及 ZIKV 性传播防控指南,本文即结合目前国内外 ZIKV 的研究进展对上述指南进行解读,内容涵盖了 ZIKV 生物学特征、流行趋势、临床表现、传播途径、实验室检查、诊断标准、预防治疗及特殊人群防控策略等,以提高临床医师对 ZIKV 及寨卡病毒病(ZVD)的认识。

  13. Insomnia medication use and the probability of an accidental event in an older adult population

    Alon Y Avidan

    2010-11-01

    Full Text Available Alon Y Avidan1, Liisa A Palmer2, Justin F Doan3, Robert W Baran31UCLA Department of Neurology, Los Angeles, CA, USA; 2Thomson Reuters, Washington, DC, USA; 3Takeda Global Research and Development Center, Deerfield, IL, USAObjective: This study examined the risk of accidental events in older adults prescribed a sedating antidepressant, long-acting benzodiazepine, short-acting benzodiazepine, and nonbenzodiazepine, relative to a reference group (selective melatonin receptor agonist.Methods: This was a retrospective cohort analysis of older adults (≥65 years with newly initiated pharmacological treatment of insomnia. Data were collected from the Thomson MarketScan® Medicare Supplemental and Coordination of Benefits databases (January 1, 2000, through June 30, 2006. Probit models were used to evaluate the probability of an accidental event.Results: Data were analyzed for 445,329 patients. Patients taking a long-acting benzodiazepine (1.21 odds ratio [OR], short-acting benzodiazepine (1.16 OR, or nonbenzodiazepine (1.12 OR had a significantly higher probability of experiencing an accidental event during the first month following treatment initiation compared with patients taking the reference medication (P < 0.05 for all. A significantly higher probability of experiencing an accidental event was also observed during the 3-month period following the initiation of treatment (1.62 long-acting benzodiazepine, 1.60 short-acting benzodiazepine, 1.48 nonbenzodiazepine, and 1.56 sedating antidepressant; P < 0.05.Conclusions: Older adults taking an SAD or any of the benzodiazepine receptor agonists appear to have a greater risk of an accidental event compared with a reference group taking an MR.Keywords: insomnia, accidental events, benzodiazepine receptor agonist, melatonin receptor agonist, older adults

  14. El estudio del factor humano en accidentes de aviación

    Sánchez Rubio, Lina María

    2010-01-01

    El factor humano ha sido considerado causa o contribución del 70 al 80% de los accidentes de aviación en el mundo, y constituye una prioridad en investigación para la seguridad aérea. Las estadísticas muestran que los índices y causas de accidentes de aviación se mantienen constantes, e identifican una importante diferencia entre regiones. La investigación científica requiere de nuevas y complementarias aproximaciones para la explicación y comprensión del factor humano en aviación. Los médico...

  15. Protocol for a randomised controlled trial of risk screening and early intervention comparing child- and family-focused cognitive-behavioural therapy for PTSD in children following accidental injury

    Nixon Reginald DV

    2010-11-01

    efficacious, this early intervention will assist in reducing symptoms of traumatic stress as well as preventing chronic disorder and disability in children experiencing acute PTSD following accidental injury. Trial Registration Controlled-trials.com: ISRCTN79049138

  16. Accidentes ocupacionales y conocimiento sobre precauciones universales en internos universitarios costarricenses

    Álvaro Rivera-Valdivia

    2005-04-01

    Full Text Available Justificación y objetivo: los internos universitarios (estudiantes de medicina en su último año son vulnerables a accidentes ocupacionales con agujas y otros objetos cortantes, especialmente debido a su inexperiencia y falta de entrenamiento aunados a su deseo de realizar una serie de nuevas actividades y procedimientos. No existe información en nuestro país con respecto a la frecuencia de este tipo de accidentes en internos universitarios de la carrera de medicina. El objetivo del presente estudio fue estudiar la frecuencia y tipo de accidentes ocupacionales sufridos con mayor frecuencia por internos de medicina y evaluar su conocimiento sobre precauciones universales. Metodología: Se realizó un estudio descriptivo de corte transversal a través de una encuesta directa y anónima. De todos los internos de medicina que trabajaban en el Valle Central de octubre de 2001 a enero de 2002 se seleccionó una muestra aleatoria de 201 internos (poder 95%, error 5%. A la población seleccionada se le aplicó una encuesta precodificada, la cual consistía en 20 preguntas estructuradas, la mayoría cerradas y tres abiertas relacionadas con la ocurrencia de accidentes ocupacionales en los médicos internos, número, tipo, acciones tomadas tras el accidente y conocimientos sobre precauciones universales. Posteriormente se hizo un análisis descriptivo de los resultados obtenidos. Resultados: de todos los participantes, 90% habían trabajado más de 3 meses como médicos internos. Más de la mitad habían realizado al menos 3 meses de rotación en una área médica y 3 meses en una área quirúrgica. La muestra incluyó estudiantes de 5 universidades diferentes. Sólo un 37% de los internos encuestados habían recibido la vacunación contra virus de la hepatitis B. Del total de internos, 64% admitió haber sufrido al menos un accidente ocupacional con sangre de algún paciente, un 20% admitió haber sufrido 3 o 4 accidentes. De los internos que

  17. Renin release

    Schweda, Frank; Friis, Ulla; Wagner, Charlotte;

    2007-01-01

    The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located......, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin...

  18. Preventing stroke

    Stroke - prevention; CVA - prevention; cerebral vascular accident - prevention; TIA - prevention, transient ischemic attack - prevention ... something that increases your chance of having a stroke. You cannot change some risk factors for stroke. ...

  19. Tratamiento de la hipertensión arterial en accidente cerebrovascular

    Luna Vela, Fredy Andrés

    2013-01-01

    Revisión sistemática de la literatura en la que se discuten las controversias del manejo de la presión arterial en las emergencias neurológicas agudas cerebrovasculares como accidente cerebrovascular isquémico, hemorrágico y hemorragia subaracnoidea.

  20. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both metaphorical

  1. Accidental Epipen injection into a digit - the value of a Google search.

    Turner, M J A; Purushotham, A D

    2004-05-01

    Despite the lack of awareness by the clinicians consulted of the most suitable treatment for accidentally injected epinephrine, this patient was successfully treated due mainly to the ability of clinicians on-site to access the Internet in the A&E department. A broad search engine such as Google can be an invaluable tool in finding important clinical information rapidly.

  2. [Accidental injection of adrenaline in a finger with EpiPen].

    Kaspersen, J; Vedsted, P

    1998-11-01

    We report a case of accidental injection of 0.3 mg epinephrine in the right pollux. The actual case was treated with systemic nitroglyceride and immersion of the finger in hot water. A review of the literature shows that the adequate treatment is local infiltration with Phentholamine Mesylate. There is a need to describe this treatment in conventional literature.

  3. Accidental Epipen injection into a digit - the value of a Google search.

    Turner, M. J. A.; Purushotham, A. D.

    2004-01-01

    Despite the lack of awareness by the clinicians consulted of the most suitable treatment for accidentally injected epinephrine, this patient was successfully treated due mainly to the ability of clinicians on-site to access the Internet in the A&E department. A broad search engine such as Google can be an invaluable tool in finding important clinical information rapidly. PMID:15140311

  4. Multiple scattering and accidental coincidences in the J-PET detector simulated using GATE package

    Kowalski, P; Wiślicki, W; Raczyński, L; Bednarski, T; Białas, P; Bułka, J; Czerwiński, E; Gajos, A; Gruntowski, A; Kamińska, D; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemień, W; Kubicz, E; Niedźwiecki, Sz; Pałka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wochlik, I; Zieliński, M; Zoń, N

    2015-01-01

    Novel Positron Emission Tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.

  5. The Costs of Cultural Change: Accidental Injury and Modernization among the Papago Indians

    Hackenberg, Robert A.; Gallagher, Mary M.

    1972-01-01

    Several theories are examined suggesting that stress associated with modernization is responsible for excesses of accidental injuries among American Indians. A preliminary version of this paper was presented at the annual meetings of the American Anthropological Association, New York, 1971. (FF)

  6. INTERNAL BALLOON TAMPONADE - A NONSURGICAL METHOD FOR REMOVAL OF ACCIDENTALLY PLACED SHEATHS FROM THE SUBCLAVIAN ARTERY

    VANDIJK, RB; DENHEIJER, P; DEMUINCK, E; LIE, KI

    1993-01-01

    One of the possible complications of subclavian vein puncture is accidental puncture of the subclavian artery. If this is not noted immediately after the puncture, insertion of a large bore sheath in the subclavian artery is likely to follow. We describe our experience with a new method that enables

  7. Estrategia de Inversiones Basada en Accidentes Aéreos: ¿Hay Retornos Anormales?

    Marcos Rosa Costa

    2013-06-01

    Full Text Available El presente trabajo buscó investigar si una estrategia de inversiones basada en accidentes aéreos generaría retornos anormales. Fue efectuado un estudio de eventos considerándose todos los accidentes aéreos ocurridos en el período de 1998 a 2009 y los datos de las compañías aéreas y de los fabricantes de las respectivas aeronaves que poseían acciones negociadas en las bolsas de valores, cuando del acontecimiento del evento. Los tests realizados se basaron en el modelo de Campbel, Lo y Mackinlay (1997, para definición de retornos anormales, por medio de una regresión lineal entre el retorno de las acciones de esas empresas y el retorno del portafolio de mercado utilizado como benchmark. Así fue posible proyectar los retornos futuros esperados para las acciones de las compañías aéreas y fabricantes y compararlos a los resultados efectivamente obtenidos en el acontecimiento del evento. El resultado obtenido sugiere que una estrategia de inversiones basada en accidentes aéreos sería viable y que retornos anormales podrían ser obtenidos en el período inmediatamente posterior a un accidente aéreo.

  8. Management of accidental dural puncture and post-dural puncture headache after labour: a Nordic survey

    Darvish, B; Gupta, A; Alahuhta, S

    2011-01-01

    a major risk with epidural analgesia is accidental dural puncture (ADP), which may result in post-dural puncture headache (PDPH). This survey was conducted to explore the incidence of ADP, the policy for management of PDPH and the educational practices in epidural analgesia during labour in the N...

  9. Intraperitoneal granulomatous foreign body reaction after accidental perforation of the abdominal wall. Case report

    Lanng, C; Winther-Nielsen, H; Hougen, H P

    2013-01-01

    After an accidental perforation by a wooden stake of the abdominal wall and distal ileum a 28-year-old man developed an aggressive granulomatous foreign body reaction of the greater omentum with high fever and abdominal pain. The patient was cured by omental resection and prednisone treatment....

  10. [Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)

    Hameleers-Snijders, P.; Hogeveen, M.; Smeitink, J.A.M.; Kramers, C.; Draaisma, J.M.T.

    2007-01-01

    Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider t

  11. La configuraci??n jur??dica del accidente de trabajo

    S??nchez P??rez, Jos??

    2013-01-01

    Esta obra incorpora un an??lisis global del accidente de trabajo y su configuraci??n jur??dica. Analiza su evoluci??n hist??rica e incorpora una selecci??n de m??s de 300 sentencias del Tribunal Supremo que permiten identificar su contenido.

  12. [Factors associated with the danger of accidental falls among institutionalized elderly individuals: an integrative review].

    Gomes, Erika Carla Cavalcanti; Marques, Ana Paula de Oliveira; Leal, Márcia Carréra Campos; Barros, Benvinda Pereira de

    2014-08-01

    The scope of this research is to identify the major risk factors associated with accidental falls among the elderly. It involves an integrative review of the literature between 2002 and 2012 in English and Portuguese. The selection of articles was based on the following key words in the Lilacs, Medline and BDENF databases: accidental falls, homes for the elderly and health services. In the final sample 19 articles were selected, of which 11 were national and 8 were international. They indicate that the major factors related to the risk of accidental falls in Homes for the Elderly are: being female, being diagnosed with chronic disease, treatment with benzodiazepine, earlier cases of accident falls, and mobility restriction. The research reveals that architectonic and furniture inadequacies in Homes for the Elderly may be predisposing factors for accidental falls. Analysis of the articles reveals the need for further longitudinal studies and, consequently, enhanced monitoring of the conditions of the functional capacity of the elderly, especially the risks related to falls, considered one of the leading causes of death among institutionalized elderly individuals.

  13. Heparin release from thermosensitive hydrogels

    Gutowska, Anna; Bae, You Han; Feijen, Jan; Kim, Sung Wan

    1992-01-01

    Thermosensitive hydrogels (TSH) were synthesized and investigated as heparin releasing polymers for the prevention of surface induced thrombosis. TSH were synthesized with N-isopropyl acrylamide (NiPAAm) copolymerized with butyl methacrylate (BMA) (hydrophobic) or acrylic acid (AAc) (hydrophilic) co

  14. Overview, prevention and management of chemotherapy extravasation.

    Kreidieh, Firas Y; Moukadem, Hiba A; El Saghir, Nagi S

    2016-02-10

    Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.

  15. Accidental nuclear excursion Recuplex operation 234-5 facility. Final report: Date of incident: April 7, 1962

    1962-08-01

    On Saturday morning, April 7, 1962, at about 1059 Armed Forces time, an accidental nuclear excursion occurred in the plutonium waste recovery facility (Recuplex) of the 234-5 Building. This excursion did not result in any mechanical damage or spread of contamination. Three employees of the General Electric Company received overexposures to gamma and neutron radiation. None were fatally exposed; in each case the overexposure was recognized promptly, and following medical observation and testing the men were released to return to work. In compliance with AEC Manual Chapter 0703, an AEC-HAPO committee composed of two AEC employees and five General Electric employees was appointed by the Manger, HOO, with the concurrence of the General Manager, HAPO, to conduct an investigation of the incident. The committee`s purpose was to determine the cause, nature, and extent of the incident, and recommend action to be taken by others to minimize or preclude future incidents of this magnitude. A study of operating practices and operating conditions that appeared to exist prior to, during, and subsequent to the accident was made by the committee. The committee believes that this report provides sufficient information to answer questions which may arise as a result of the criticality incident except those relating to its cause.

  16. Probabilistic margin evaluation on accidental transients for the ASTRID reactor project

    Marquès, Michel

    2014-06-01

    ASTRID is a technological demonstrator of Sodium cooled Fast Reactor (SFR) under development. The conceptual design studies are being conducted in accordance with the Generation IV reactor objectives, particularly in terms of improving safety. For the hypothetical events, belonging to the accidental category "severe accident prevention situations" having a very low frequency of occurrence, the safety demonstration is no more based on a deterministic demonstration with conservative assumptions on models and parameters but on a "Best-Estimate Plus Uncertainty" (BEPU) approach. This BEPU approach ispresented in this paper for an Unprotected Loss-of-Flow (ULOF) event. The Best-Estimate (BE) analysis of this ULOFt ransient is performed with the CATHARE2 code, which is the French reference system code for SFR applications. The objective of the BEPU analysis is twofold: first evaluate the safety margin to sodium boiling in taking into account the uncertainties on the input parameters of the CATHARE2 code (twenty-two uncertain input parameters have been identified, which can be classified into five groups: reactor power, accident management, pumps characteristics, reactivity coefficients, thermal parameters and head losses); secondly quantify the contribution of each input uncertainty to the overall uncertainty of the safety margins, in order to refocusing R&D efforts on the most influential factors. This paper focuses on the methodological aspects of the evaluation of the safety margin. At least for the preliminary phase of the project (conceptual design), a probabilistic criterion has been fixed in the context of this BEPU analysis; this criterion is the value of the margin to sodium boiling, which has a probability 95% to be exceeded, obtained with a confidence level of 95% (i.e. the M5,95percentile of the margin distribution). This paper presents two methods used to assess this percentile: the Wilks method and the Bootstrap method ; the effectiveness of the two methods

  17. News release

    2005-01-01

    A few days ago. the State Bureau of Quality Inspection declared the sample result of ceramic tiles and sanitarywares. 47 out of 62 types of ceramic tiles sampled are qualified. the qualified rate of which is 75.8%. Six types of ceramic tiles are exposed for exceeding the standard of radiation, 58 out of 87 types of sanitarywares are qualified, the qualified rate of which is 66.7%. Eight types of sanitarywares are exposed for the lack of foul smells prevention function.

  18. The efficacy of fluoride-releasing cements on preventing enamel demineralization during orthodontic treatments%氟缓释型粘结剂预防正畸治疗中釉质脱矿的疗效观察

    冯伟; 王晓玲; 李琥

    2016-01-01

    Objective To investigate the effectiveness of fluoride⁃releasing orthodontic bonding cements on preventing enamel demi⁃neralization around brackets during orthodontic treatment. Methods A total of 24 participants were included. All the teeth were divid⁃ed into two groups:one side of teeth were applied with resin modified glass ionomer ( GC) , while the contralateral teeth were assigned to receive resin bonding system including self⁃ecthing primer ( Transbond) . DIGNOdent was used to observe the possible demineraliza⁃tion immediately, three months and six months after bonding. EDI index and the detection rate of white spot lesion were recorded to e⁃valuate enamel demineralization situation. Results There were no significant differences among two groups regarding EDI, DD and WSL before and 3 months after orthodontic treatment. The data indicated a significant 1ower EDI, DD and WSL in the GC group than those in the Transbond group ( P<0.05) after six months. Conclusion Both fluoride⁃releasing bonding systems can reduce the demi⁃neralization, but resin modified ionomer has a better long⁃term effect.%目的:观察含氟离子释放型的正畸粘结剂在预防固定正畸治疗中牙釉质表面脱矿的临床疗效。方法选择24例固定矫治的正畸患者,采用自身对照法分别用树脂增强型玻璃离子粘结剂( GC)和含自酸蚀底涂剂的树脂粘结剂( Transbond)粘固托槽,于正畸治疗前、治疗后3个月及治疗后6个月应用DIGNOdent激光龋齿诊断仪检测牙釉质表面,分析前后仪器读数( DD)的变化反映牙釉质脱矿的情况,同时观察并记录牙釉质脱矿指数( EDI)及釉质白斑( WSL)的检出率。结果在治疗前及治疗3个月后两组间的EDI值、DD值、WSL值比较,差异均无统计学意义(P>0.05),而在治疗6个月后,GC组的EDI值、DD值、WSL值显著小于Transbond组,差异有统计学意义( P<0.05)。结论树脂

  19. Dutch distribution zones of stable iodine tablets based on atmospheric dispersion modelling of accidental releases from nuclear power plants.

    Kok-Palma, Y.S.; Leenders, M.; Meulenbelt, J.

    2010-01-01

    Rapid administration of stable iodine is essential for the saturation and subsequent protection of the thyroid gland against the potential harm caused by radioiodines. This paper proposes the Dutch risk analysis that uses an atmospheric dispersion model to calculate the size of the zones around nucl

  20. Radiation monitoring systems as a tool for assessment of accidental releases at the Chernobyl and Fukushima NPPs

    Shershakov, Vjacheslav; Bulgakov, Vladimir

    2013-04-01

    The experience gained during mitigation of the consequences of the accidents at the Chernobyl and Fukushima NPPs has shown that what makes different the decision-making in case of nuclear accidents is that the greatest benefit from decision-making can be achieved in the early phase of an accident. Support to such process can be provided only by a real-time decision-making support system. In case of a nuclear accident the analysis of the situation and decision-making is not feasible without an operational radiation monitoring system, international data exchange and automated data processing, and the use of computerized decision-making support systems. With this in mind, in the framework of different international programs on the Chernobyl-related issues numerous projects were undertaken to study and develop a set of methods, algorithms and programs providing effective support to emergency response decision-making, starting from accident occurrence to decision-making regarding countermeasures to mitigate effects of radioactive contamination of the environment. The presentation focuses results of the analysis of radiation monitoring data and, on this basis, refining or, for many short-lived radionuclides, reconstructing the source term, modeling dispersion of radioactivity in the environment and assessing its impacts. The obtained results allowed adding and refining the existing estimates and in some cases reconstructing doses for the public on the territories contaminated as a result of the Chernobyl accident. The activities were implemented in two stages. In the first stage, several scenarios for dispersion of Chernobyl-related radioactivity were developed. For each scenario cesium-137 dispersion was estimated and these estimates were compared with measurement data. In the second stage, the scenario which showed the best agreement of calculations and measurements was used for modeling the dispersion of iodine-131and other short-lived radionuclides. The described approach was used for assessing the consequences at the Fukushima NPP. These results are also provided in the presentation. References 1. Kelly G.N., Ehrhardt J., Shershakov V.M.. Decision Support for Off-Site Emergency Preparedness in Europe. Radiation Protection Dosimetry, Vol. 64 Nos. 1-2, 1996, pp. 129-142. 2. Ehrhardt J., Shershakov V.M. Real-time on-line decision support systems (RODOS) for off-site emergency management following a nuclear accident. EUR 16533, 1996 3. Kelly G.N., Shershakov V.M. (Editors). Environmental contamination, radiation doses and health consequences after the ?hernobyl accident. Radiation Protection Dosimetry. Special Commemorative Issue.Vol. 64, 1996 4. Shershakov V.M. Computer information technology for support of radiation monitoring problems. OECD Proceedings of an International Workshop «Nuclear Emergency Data Management», Zurich, Switzerland, 1998, pp. 377-388 5. Pitkevich V.A., Duba V.V., Ivanov V.K., Tsyb A.F., Shershakov V.M., Golubenkov A.V., Borodin R.V., V.A., Kosykh V.S. Reconstruction of External Dose to the Inhabitants Living in the Contaminated Territory of Russia by the Results of the Accident at the Chernobyl NPP. Health Phys., Vol. 30, No. 1, pp. 54-68, 1995. 6. Shershakov V., Fesenko S., Kryshev I., Semioshkina T. Decision-Aiding Tools for Remediation Strategies. In: Radioactivity in the Environment, Volume 14, Remediation of Contaminated Environments, 2009, pp 41- 120, Elsevier Ltd.

  1. Contact: Releasing the news

    Pinotti, Roberto

    The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

  2. Influence of gonadotropin-releasing hormone agonist on the effect of chemotherapy upon ovarian cancer and the prevention of chemotherapy-induced ovarian damage: an experimental study with nu/nu athymic mice

    Qiong-yan LIN; Yi-feng WANG; Hui-nan WENG; Xiu-jie SHENG; Qing-ping JIANG; Zhi-ying YANG

    2012-01-01

    Background and objective:Gonadotropin-releasing hormone (GnRH) plays an important role in the regulation of ovarian function and ovarian cancer cell growth.In this study,we determined whether administration of the GnRH agonist (GnRHa),triporelin,prior to cisplatin treatment affects cisplatin and/or prevents cisplatin-induced ovarian damage.Methods:nu/nu mice were injected with ovarian cancer OVCAR-3 cells intraperitoneally.After two weeks,the mice were treated with saline (control),cisplatin,GnRHa,or cisplatin plus GnRHa for four weeks.At the end of the experimental protocol,blood,tumor,ovary,and uterine tissues were resected for hematoxylin and eosin (H&E) staining,immunohistochemical analyses of Ki67,nuclear factor-κB (NF-κB),and caspase-3,transmission electron microscopy of apoptosis,or enzyme-linked immunosorbent assay (ELISA) analyses of anti-Mullerian hormone (AMH).Results:Cisplatin treatment effectively inhibited tumor growth in mice treated with human ovarian cancer cells; however the treatment also induced considerable toxicity.Immunohistochemical analyses showed that Ki67 expression was reduced in cisplatin-treated mice compared to control (P<0.05),but there was no statistically significant differences between cisplatin-treated mice and cisplatin plus GnRHa-treated mice (P>0.05),while expressions of NF-κB and caspase-3 were reduced and induced,respectively,in cisplatin-treated mice and cisplatin plus GnRHa-treated mice.Apoptosis occurred in the GnRHa,cisplatin,and cisplatin plus GnRHa-treated mice,but not in control mice.Ovaries exposed to GnRHa in both GnRHa mice and cisplatin-treated mice (combination group) had significantly more primordial and growth follicles and serum levels of AMH than those in the control mice and cisplatin-treated mice (P<0.05).Conclusions:Administration of GnRHa to mice significantly decreased the extent of ovarian damage induced by cisplatin,but did not affect the anti-tumor activity of cisplatin.

  3. Trabalho precoce e acidentes ocupacionais na adolescência Trabajo precoz y accidentes de trabajo en la adolescencia Child labor and occupational accidents in the adolescence

    Márcia Elena Andrade Santos

    2009-12-01

    Full Text Available Estudo transversal, descritivo e quantitativo, com o objetivo de investigar a ocorrência de acidentes ocupacionais em adolescentes trabalhadores. Realizado de abril a agosto de 2008, com uma amostra aleatória de 308 adolescentes entre 14 e 18 anos de idade. Os resultados evidenciaram que 168 (54,5% eram trabalhadores, 42%, desses, alegaram ter sofrido acidentes típicos, (18,5% acidentes de trajeto, 14,9% afastaram-se do trabalho, 51,4% não tinham carteira assinada e a maioria era do sexo masculino. Os cortes e perfurações foram os acidentes mais ocorridos (27,5%, a queimadura constituiu o principal agravo (26,9% e as partes do corpo mais afetadas foram mãos e dedos (40,4%. Conclui-se que os acidentes ocupacionais configuram-se como uma expressão da violência contra os jovens trabalhadores e um grave problema de Saúde Pública. Deve ser incorporado com prioridade na agenda dos serviços públicos e o enfermeiro, junto à equipe de saúde, podem ser os principais articuladores desse processo.Estudio transversal, descriptivo y cuantitativo, que tiene como finalidad investigar la ocurrencia de accidentes de trabajo en los trabajadores jóvenes. Realizado entre abril y agosto del 2008, con una muestra aleatoria de 308 adolescentes de 14 y 18 años de edad. Los resultados mostraron que 168 (54,5% eran trabajadores, el 42% de éstos afirma haber sufrido accidentes típicos, 18,5% fueron accidentes de trayecto, el 14,9% no pudieron trabajar después del accidente, el 51,4% no tenía un contrato formal de trabajo y la mayoría era del sexo masculino. Cortes y pinchazos fueron los accidentes con mayor incidencia (27,5%, la quemadura fue la lesión principal (26,9% y las partes del cuerpo más afectadas fueron las manos y los dedos (40,4%. Se concluyó que los accidentes de trabajo se caracterizan como una expresión de la violencia contra los trabajadores jóvenes y como un grave problema de salud pública. Por lo tanto, esta cuestión deber

  4. Accidental injury of the inferior alveolar nerve due to the extrusion of calcium hydroxide in endodontic treatment: a case report.

    Shin, Yooseok; Roh, Byoung-Duck; Kim, Yemi; Kim, Taehyeon; Kim, Hyungjun

    2016-02-01

    During clinical endodontic treatment, we often find radiopaque filling material beyond the root apex. Accidental extrusion of calcium hydroxide could cause the injury of inferior alveolar nerve, such as paresthesia or continuous inflammatory response. This case report presents the extrusion of calcium hydroxide and treatment procedures including surgical intervention. A 48 yr old female patient experienced Calcipex II extrusion in to the inferior alveolar canal on left mandibular area during endodontic treatment. After completion of endodontic treatment on left mandibular first molar, surgical intervention was planned under general anesthesia. After cortical bone osteotomy and debridement, neuroma resection and neurorrhaphy was performed, and prognosis was observed. But no improvement in sensory nerve was seen following surgical intervention after 20 mon. A clinician should be aware of extrusion of intracanal medicaments and the possibility of damage on inferior alveolar canal. Injectable type of calcium hydroxide should be applied with care for preventing nerve injury. The alternative delivery method such as lentulo spiral was suggested on the posterior mandibular molar.

  5. 49 CFR 236.790 - Release, time.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Release, time. 236.790 Section 236.790... Release, time. A device used to prevent the operation of an operative unit until after the expiration of a predetermined time interval after the device has been actuated....

  6. News | Division of Cancer Prevention

    News about scientific advances in cancer prevention, program activities, and new projects are included here in NCI press releases and fact sheets, articles from the NCI Cancer Bulletin, and Clinical Trial News from the NCI website.

  7. National Atmospheric Release Advisory Center (NARAC) Capabilities for Homeland Security

    Sugiyama, G; Nasstrom, J; Baskett, R; Simpson, M

    2010-03-08

    The Department of Energy's National Atmospheric Release Advisory Center (NARAC) provides critical information during hazardous airborne releases as part of an integrated national preparedness and response strategy. Located at Lawrence Livermore National Laboratory, NARAC provides 24/7 tools and expert services to map the spread of hazardous material accidentally or intentionally released into the atmosphere. NARAC graphical products show affected areas and populations, potential casualties, and health effect or protective action guideline levels. LLNL experts produce quality-assured analyses based on field data to assist decision makers and responders. NARAC staff and collaborators conduct research and development into new science, tools, capabilities, and technologies in strategically important areas related to airborne transport and fate modeling and emergency response. This paper provides a brief overview of some of NARAC's activities, capabilities, and research and development.

  8. Probabilistic consequence model of accidenal or intentional chemical releases.

    Chang, Y.-S.; Samsa, M. E.; Folga, S. M.; Hartmann, H. M.

    2008-06-02

    In this work, general methodologies for evaluating the impacts of large-scale toxic chemical releases are proposed. The potential numbers of injuries and fatalities, the numbers of hospital beds, and the geographical areas rendered unusable during and some time after the occurrence and passage of a toxic plume are estimated on a probabilistic basis. To arrive at these estimates, historical accidental release data, maximum stored volumes, and meteorological data were used as inputs into the SLAB accidental chemical release model. Toxic gas footprints from the model were overlaid onto detailed population and hospital distribution data for a given region to estimate potential impacts. Output results are in the form of a generic statistical distribution of injuries and fatalities associated with specific toxic chemicals and regions of the United States. In addition, indoor hazards were estimated, so the model can provide contingency plans for either shelter-in-place or evacuation when an accident occurs. The stochastic distributions of injuries and fatalities are being used in a U.S. Department of Homeland Security-sponsored decision support system as source terms for a Monte Carlo simulation that evaluates potential measures for mitigating terrorist threats. This information can also be used to support the formulation of evacuation plans and to estimate damage and cleanup costs.

  9. Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report.

    Sariaslani, Payam; Ghanbari, Ali; Ghanbari, Parvin

    2012-01-01

    Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital (Kermanshah, Iran) with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI) was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy.

  10. Accidental Displacement of Third Molar into the Sublingual Space: a Case Report

    Rubens Jorge

    2014-10-01

    Full Text Available Background: Successful extraction of third molars depends on preoperative diagnosis and planning. Gold standard preoperative examinations are performed through computed tomography, decreasing risks and avoiding potential accidents. The present report highlights the value of preoperative examinations in face of accidentally displaced third molars. Methods: An 18-years-old female patient underwent a third mandibular molar extraction with a general dentist. Accidentally, the mandibular left third molar was displaced into the sublingual space, making necessary a second surgical step. The surgery was interrupted and the patient was referred to an expert in maxillofacial surgery. Results: After 21 days awaiting an asymptomatic health status, the second surgical step was successfully performed using multislice computed tomography as preoperative imaging guide. Conclusions: The present case report highlights the clinical usefulness of imaging planning and informed consents in face of legal and ethic potential complaints.

  11. Marine oil spill risk mapping for accidental pollution and its application in a coastal city.

    Lan, Dongdong; Liang, Bin; Bao, Chenguang; Ma, Minghui; Xu, Yan; Yu, Chunyan

    2015-07-15

    Accidental marine oil spill pollution can result in severe environmental, ecological, economic and other consequences. This paper discussed the model of Marine Oil Spill Risk Mapping (MOSRM), which was constructed as follows: (1) proposing a marine oil spill risk system based on the typical marine oil spill pollution accidents and prevailing risk theories; (2) identifying suitable indexes that are supported by quantitative sub-indexes; (3) constructing the risk measuring models according to the actual interactions between the factors in the risk system; and (4) assessing marine oil spill risk on coastal city scale with GIS to map the overall risk. The case study of accidental marine oil spill pollution in the coastal area of Dalian, China was used to demonstrate the effectiveness of the model. The coastal areas of Dalian were divided into three zones with risk degrees of high, medium, and low. And detailed countermeasures were proposed for specific risk zones.

  12. A Precise Analytic Delayed Coincidence Efficiency and Accidental Coincidence Rate Calculation

    Yu, Jingyi; Chen, Shaomin

    2013-01-01

    In a delayed coincidence experiment, for example, the recent reactor neutrino oscillation experiments, a precise analytic determination of the delayed coincidence signal efficiency and the accidental coincidence background rate is important for the high accuracy measurement of the oscillation parameters and to understand systematic uncertainties associated with fluctuations in muon rate and random background rate. In this work, a data model is proposed to describe the full time sequence of all possible events on the live time axis. The acceptance of delayed coincidence signals, the rate of accidental backgrounds and other coincidence possibilities are calculated by assuming that all of the `net muons' are uniformly distributed on the live time axis. The intrinsic relative uncertainties in the event rates are at the $10^{-5}$ level for all combinations. The model and predictions are verified with a high statistics Monte Carlo study with a set of realistic parameters.

  13. Accidental versus operational oil spills from shipping in the Baltic Sea: risk governance and management strategies.

    Hassler, Björn

    2011-03-01

    Marine governance of oil transportation is complex. Due to difficulties in effectively monitoring procedures on vessels en voyage, incentives to save costs by not following established regulations on issues such as cleaning of tanks, crew size, and safe navigation may be substantial. The issue of problem structure is placed in focus, that is, to what degree the specific characteristics and complexity of intentional versus accidental oil spill risks affect institutional responses. It is shown that whereas the risk of accidental oil spills primarily has been met by technical requirements on the vessels in combination with Port State control, attempts have been made to curb intentional pollution by for example increased surveillance and smart governance mechanisms such as the No-Special-Fee system. It is suggested that environmental safety could be improved by increased use of smart governance mechanisms tightly adapted to key actors' incentives to alter behavior in preferable directions.

  14. Multifocal Inflammatory Leukoencephalopathy Induced by Accidental Consumption of Levamisole: A Case Report

    Ali Ghanbari

    2012-01-01

    Full Text Available Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocalinflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital(Kermanshah, Iran with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy.

  15. Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report

    Sariaslani, Payam; Ghanbari, Parvin

    2012-01-01

    Levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. The present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. A 53-year-old male was admitted to the Neurology Department of Farabi Hospital (Kermanshah, Iran) with walking inability and recognition disorder. Following clinical examinations, the patient diagnosed as multifocal inflammatory leukoencephalopathy following levamisole consumption.The patient was treated with intravenous methylprednisolone followed by prednisolone. The magnetic resonance imaging (MRI) was done 1 month later and did not show a reduction or remission in the lesions. History of the patient showed that he had accidentally consumed levamisole 8 months ago. It seems that the consumption of levamisole can induce multifocal inflammatory leukoencephalopathy and delayed treatment of the patient with corticosteroid cannot diminish the neurotoxicity of levamisole. In addition, the cytotoxic dose of levamisole induces irreversible multifocal inflammatory leukoencephalopathy. PMID:24250864

  16. Bullying Prevention for Kids

    2012-01-19

    This podcast discusses what victims of bullying may experience and provides recommendations for coping with it.  Created: 1/19/2012 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 1/19/2012.

  17. Preventing Skin Cancer

    2016-05-18

    A man and a woman talk about how they’ve learned to protect their skin from the sun over the years. .  Created: 5/18/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 5/18/2016.

  18. Injury Prevention Research

    2009-09-01

    Research provides the knowledge that we need to understand what is possible, what is not, and the best way to proceed in our intervention efforts.  Created: 9/1/2009 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 9/1/2009.

  19. Salade malade: malignant ventricular arrhythmias due to an accidental intoxication with Aconitum napellus

    Weijters, B.J.; Verbunt, R.J.A.M.; Hoogsteen, J.; Visser, R.F.

    2008-01-01

    Intoxication with Aconitum napellus is rare in our regions. Aconite alkaloids can cause ventricular arrhythmia by a prolonged activation of sodium channels. Because the margin of safety is low between the analgesic and toxic dose, intoxication is not rare when Aconite is used in herbal medicine. We present a case in which a 39-year-old male was accidentally intoxicated with Aconite. Even though no antidote or adequate therapy is available he was successfully resuscitated. (Neth Heart J 2008;1...

  20. Current controversies in the interpretation of non-accidental head injury

    Jaspan, Tim [Imaging Centre, University Hospital, Nottingham (United Kingdom)

    2008-06-15

    The field of non-accidental injury (NAI) has been the subject of a number of theories and hypotheses of variable merit. Concerning injuries that occur within the intracranial compartment, much research has been undertaken to investigate the cause of SDH and parenchymal brain injury. Much, however, remains contentious, particularly regarding the medicolegal aspects of suspected child abuse. Issues that present the greatest challenges will be addressed. (orig.)

  1. Artritis tuberculosa - Autoinoculación en profesional sanitario por accidente laboral

    Sara Cardoso

    2012-12-01

    Los autores describen un caso de monoartritis tuberculosa en un médico traumatólogo previamente sano, por inoculación accidental durante el drenaje quirúrgico de una artritis séptica. El tratamiento oral con fármacos antituberculosos y el drenaje quirúrgico fueron suficientes, sin tener que recurrir a la sinovectomía.

  2. The Impacts of Air Temperature on Accidental Casualties in Beijing, China

    Ma, Pan; Wang, Shigong; Fan, Xingang; Li, Tanshi

    2016-01-01

    Emergency room (ER) visits for accidental casualties, according to the International Classification of Deceases 10th Revision Chapters 19 and 20, include injury, poisoning, and external causes (IPEC). Annual distribution of 187,008 ER visits that took place between 2009 and 2011 in Beijing, China displayed regularity rather than random characteristics. The annual cycle from the Fourier series fitting of the number of ER visits was found to explain 63.2% of its total variance. In this study, the possible effect and regulation of meteorological conditions on these ER visits are investigated through the use of correlation analysis, as well as statistical modeling by using the Distributed Lag Non-linear Model and Generalized Additive Model. Correlation analysis indicated that meteorological variables that positively correlated with temperature have a positive relationship with the number of ER visits, and vice versa. The temperature metrics of maximum, minimum, and mean temperatures were found to have similar overall impacts, including both the direct impact on human mental/physical conditions and indirect impact on human behavior. The lag analysis indicated that the overall impacts of temperatures higher than the 50th percentile on ER visits occur immediately, whereas low temperatures show protective effects in the first few days. Accidental casualties happen more frequently on warm days when the mean temperature is higher than 14 °C than on cold days. Mean temperatures of around 26 °C result in the greatest possibility of ER visits for accidental casualties. In addition, males were found to face a higher risk of accidental casualties than females at high temperatures. Therefore, the IPEC-classified ER visits are not pure accidents; instead, they are associated closely with meteorological conditions, especially temperature. PMID:27827842

  3. The Impacts of Air Temperature on Accidental Casualties in Beijing, China

    Pan Ma

    2016-11-01

    Full Text Available Emergency room (ER visits for accidental casualties, according to the International Classification of Deceases 10th Revision Chapters 19 and 20, include injury, poisoning, and external causes (IPEC. Annual distribution of 187,008 ER visits that took place between 2009 and 2011 in Beijing, China displayed regularity rather than random characteristics. The annual cycle from the Fourier series fitting of the number of ER visits was found to explain 63.2% of its total variance. In this study, the possible effect and regulation of meteorological conditions on these ER visits are investigated through the use of correlation analysis, as well as statistical modeling by using the Distributed Lag Non-linear Model and Generalized Additive Model. Correlation analysis indicated that meteorological variables that positively correlated with temperature have a positive relationship with the number of ER visits, and vice versa. The temperature metrics of maximum, minimum, and mean temperatures were found to have similar overall impacts, including both the direct impact on human mental/physical conditions and indirect impact on human behavior. The lag analysis indicated that the overall impacts of temperatures higher than the 50th percentile on ER visits occur immediately, whereas low temperatures show protective effects in the first few days. Accidental casualties happen more frequently on warm days when the mean temperature is higher than 14 °C than on cold days. Mean temperatures of around 26 °C result in the greatest possibility of ER visits for accidental casualties. In addition, males were found to face a higher risk of accidental casualties than females at high temperatures. Therefore, the IPEC-classified ER visits are not pure accidents; instead, they are associated closely with meteorological conditions, especially temperature.

  4. Analizan partículas calientes del accidente nuclear de Palomares

    2012-01-01

    Investigadores pertenecientes al Centro Nacional de Aceleradores, CNA, (Universidad de Sevilla-Junta de Andalucía-CSIC) en colaboración con la Organización Internacional de la Energía Atómica (IAEA), han llevado a cabo me didas de elementos transuránicos en partículas calientes procedentes de accidentes nucleares tales como el de Thule (Groenlandia) o Palomares (España).

  5. Cuidado popular de familias con un adulto mayor sobreviviente del primer accidente cerebrovascular

    Lucero López-Díaz; Fabiola Castellanos-Soriano; Esperanza Muñoz-Torres

    2016-01-01

    Introducción: el accidente cerebrovascular afecta a numerosas personas en el mundo y se constituye en la principal causa de muer- te. Los sobrevivientes pueden padecer discapacidad y sufrir modificaciones en las actividades cotidianas. La familia es el principal apoyo del sobreviviente y al ser parte de una misma cultura, construye acciones de cuidado en búsqueda del bienestar. Objetivo: describir las acciones del cuidado popular de las familias con un adulto mayor sobreviviente del prim...

  6. Los accidentes laborales, su impacto económico y social

    Miguel Antonio Cisneros-Prieto

    2015-01-01

    Full Text Available Este artículo investigativo aborda la problemática de los accidentes de trabajo en las empresas estatales en la provincia Holguín y la importancia de la determinación efectiva de las causas que los provocan, a partir del análisis del comportamiento de los indicadores emitidos por la Oficina Nacional de Estadística e Información (ONEI hasta el año 2014. Se analiza el comportamiento, en el período comprendido entre el 2011-2014, de las cifras de trabajadores lesionados y fallecidos, y se evalúa el impacto humano, económico y social de la accidentalidad en las empresas y la sociedad. Se demuestra un incremento en el indicador “Días perdidos por accidentados”, siendo la principal lectura de este comportamiento el aumento de la gravedad de los accidentes de trabajo, este es un elemento que generalmente las organizaciones no valoran en su verdadera magnitud como un significativo impacto negativo de su eficiencia económica y financiera. Se presenta un enfoque sobre las potencialidades de la comunicación en función de la solución o atenuación de la ocurrencia de los accidentes y en consecuencia ladisminución del costo financiero y social de esta compleja problemática.

  7. Decay Heat Removal and Transient Analysis in Accidental Conditions in the EFIT Reactor

    Giacomino Bandini

    2008-01-01

    Full Text Available The development of a conceptual design of an industrial-scale transmutation facility (EFIT of several 100 MW thermal power based on accelerator-driven system (ADS is addressed in the frame of the European EUROTRANS Integral Project. In normal operation, the core power of EFIT reactor is removed through steam generators by four secondary loops fed by water. A safety-related decay heat removal (DHR system provided with four independent inherently safe loops is installed in the primary vessel to remove the decay heat by natural convection circulation under accidental conditions which are caused by a loss-of-heat sink (LOHS. In order to confirm the adequacy of the adopted solution for decay heat removal in accidental conditions, some multi-D analyses have been carried out with the SIMMER-III code. The results of the SIMMER-III code have been then used to support the RELAP5 1D representation of the natural circulation flow paths in the reactor vessel. Finally, the thermal-hydraulic RELAP5 code has been employed for the analysis of LOHS accidental scenarios.

  8. Humeral fracture in non-ambulant infants - a possible accidental mechanism

    Somers, John M.; Halliday, Katharine E. [Nottingham University Hospitals, Radiology Department, Nottingham (United Kingdom); Chapman, Stephen [Birmingham Children' s Hospital, Birmingham (United Kingdom)

    2014-10-15

    Humeral fracture in a non-ambulant infant younger than 1 year is suspicious for a non-accidental injury unless there is a credible accidental explanation. A previously unrecognised accidental mechanism was described in 1996 whereby a 5-month-old infant was rolled by a 3-year-old sibling from a prone to a supine position. To investigate the widely accepted view that an infant with limited mobility cannot sustain a fracture of the humerus by his or her own actions in the absence of the intervention of an external party. We present seven cases of non-ambulant infants between 4 and 7 months of age in whom an isolated humeral fracture was the only injury present. In each case the caregiver described the fracture occurring when the child rolled over, trapping the dependent arm, without the intervention of another party. There is no proof for this mechanism in the form of an independent witness or video recording. However, we propose that this mechanism is worthy of further consideration as a rare and unusual cause for the injury. Further study is required. (orig.)

  9. Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

    Arlines Piña-Tornés

    Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.

  10. Study of TSL and OSL properties of dental ceramics for accidental dosimetry applications

    Veronese, Ivan, E-mail: ivan.veronese@unimi.i [Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Galli, Anna [CNR-INFM, via Cozzi 53, 20125 Milano (Italy); Dipartimento di Scienza dei Materiali, Universita degli Studi di Milano Bicocca and INFN Sezione di Milano Bicocca, via Cozzi 53, 20125 Milano (Italy); Cantone, Marie Claire [Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Martini, Marco [Dipartimento di Scienza dei Materiali, Universita degli Studi di Milano Bicocca and INFN Sezione di Milano Bicocca, via Cozzi 53, 20125 Milano (Italy); Vernizzi, Fabrizio; Guzzi, Gianpaolo [Italian Association for Metals and Biocompatibility Research - A.I.R.M.E.B., Milan (Italy)

    2010-01-15

    Interest is increasing in the development of new methodologies for accidental dose assessment, exploiting the luminescence and dosimetric properties of objects and materials which can be usually found directly on exposed subjects and/or in the contaminated area. In this work, several types of ceramics employed for dental prosthetics restoration, including both innovative materials used as sub-frames for the construction of the inner part of dental crowns (core), and conventional porcelains used for the fabrication of the external layer (veneer), were investigated with regard to their thermally and optically stimulated luminescence (TSL and OSL respectively) properties, in view of their potential application in accidental dosimetry. The sensitivity to ionizing radiation proved to strongly depend on the type and brand of ceramic, with minimum detectable dose ranging from few mGy up to several tens of mGy. A linear dose-response was observed for most of the samples. However, the luminescence signals were characterised by a significant fading, which has to be taken into account for a reliable accidental dose assessment after a radiation exposure event.

  11. Cuidado popular de familias con un adulto mayor sobreviviente del primer accidente cerebrovascular

    Lucero López-Díaz

    2016-01-01

    Full Text Available Introducción: el accidente cerebrovascular afecta a numerosas personas en el mundo y se constituye en la principal causa de muer- te. Los sobrevivientes pueden padecer discapacidad y sufrir modificaciones en las actividades cotidianas. La familia es el principal apoyo del sobreviviente y al ser parte de una misma cultura, construye acciones de cuidado en búsqueda del bienestar. Objetivo: describir las acciones del cuidado popular de las familias con un adulto mayor sobreviviente del primer accidente cerebrovascular. Método: estudio etnográfico, con observación participante y entrevistas en profundidad. Participaron siete familias bogotanas (siete adultos mayores entre los dos y diez meses posteriores al primer accidente cerebrovascular y los siete cuidadores principales respectivos. Resultados: cuidadores y adulto mayor comparten acciones de cuidado para la recuperación, relacionadas con la alimentación, el cuidado personal y la ingesta de medicamentos permeadas por la creencia religiosa, fuente de soporte y vínculo afectivo. Conclusión: conocer el cuidado popular de esta población posibilita proponer acciones culturalmente congruentes con sus valores y creencias para potencializar las ca- pacidades familiares e intermediar en los procesos de tratamiento.

  12. Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

    Arlines Piña-Tornés

    2014-10-01

    Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.

  13. Accidental Coverage of Both Renal Arteries during Infrarenal Aortic Stent-Graft Implantation: Cause and Treatment

    Umberto Marcello Bracale

    2014-01-01

    Full Text Available The purpose of this paper is to report a salvage maneuver for accidental coverage of both renal arteries during endovascular aneurysm repair (EVAR of an infrarenal abdominal aortic aneurysm (AAA. A 72-year-old female with a 6 cm infrarenal abdominal aortic aneurysm was treated by endovascular means with a standard bifurcated graft. Upon completing an angiogram, both renal arteries were found to be accidentally occluded. Through a left percutaneous brachial approach, the right renal artery was catheterized and a chimney stent was deployed; however this was not possible for the left renal artery. A retroperitoneal surgical approach was therefore carried out with a retrograde chimney stent implanted to restore blood flow. After three months, both renal arteries were patent and renal function was not different from the baseline. Both endovascular with percutaneous access via the brachial artery and open retroperitoneal approaches with retrograde catheterization are feasible rescue techniques to recanalize the accidentally occluded renal arteries during EVAR.

  14. Accidental hanging: a novel mobile suspension apparatus partially hidden inside the clothes.

    Kodikara, Sarathchandra

    2012-12-01

    Accidental hanging is uncommon. An immobile/fixed and exposed suspension apparatus is seen in almost all cases of hanging. A 50-year-old man, who was drunk, was trying to steal an iron rod by hiding it under his clothing. To secure hiding, he attached it to his body by a loose ligature around the neck, the waist belt of the sarong, and another band around the waist and by his underwear. Sometime later, because of ethanol intoxication, he fell asleep in the sitting position. While he was sitting on the floor, the iron rod was lifted up accidentally, and its upper end was wedged against the wall behind the victim, and the lower end was fixed against the floor. When he fell asleep, the weight of the tilted head acted as the constricting force compressing the neck by the ligature that was used to attach the iron rod to the neck. The cause of death was concluded as hanging in a man with ethanol intoxication. This case highlights a novel mobile suspension apparatus partially hidden inside the clothes, in a case of accidental hanging. A similar case has not been reported in the forensic literature.

  15. Fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity

    Panayotidis, Costas; Foidart, Jean-Michel; Nisolle, Michelle

    2008-01-01

    This article presents for the first time in the literature a case of fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity. Peer reviewed

  16. An atypical case of successful resuscitation of an accidental profound hypothermia patient, occurring in a temperate climate.

    Coleman, E

    2010-03-01

    Cases of accidental profound hypothermia occur most frequently in cold, northern climates. We describe an atypical case, occurring in a temperate climate, where a hypothermic cardiac-arrested patient was successfully resuscitated using extracorporeal circulation (ECC).

  17. El subregistro de accidentes de trabajo en una Unidad de Medicina Familiar del Instituto Mexicano del Seguro Social. Subregistro de accidentes de trabajo en asegurados

    Patricia Pérez Martínez

    2008-09-01

    Full Text Available Objetivo: Determinar el subregistro de los accidentes de trabajo en una Unidad de Medicina Familiar (UMFX escogida, inicialmente atendidos en el servicio de urgencias de un Hospital General de Zona (HGZ, del Instituto Mexicano del Seguro Social (IMSS en el año 2002. Material y métodos: Es un estudio transversal que utilizó información de la fuente original del HGZ que otorga la primera atención médica. Se elaboró una cédula de registro con las diversas fuentes de información, efectuando confrontación, seguimiento y análisis estadístico de las mismas. Resultados: De 6551 probables accidentes de trabajo atendidos en el HGZ, se seleccionaron 821 casos adscritos a la UMFX escogida. Se conformaron tres grupos de acuerdo con su dictamen: Grupo I= SÍ de trabajo, 35.4% (290; Grupo II=NO de trabajo, 4.6% (38, y el Grupo III= no calificados y atendidos en urgencias, 60%(493; este último representa el subregistro de los accidentes de trabajo. Conclusiones: El subregistro del 60% es de los más altos reportado en la literatura, lo cual representa para el IMSS, los trabajadores y el país graves repercusiones económicas y sociales no cuantificadas.Objective: To determine the Occupational Accidents Subregistry at a selected Family Medicine Unit (FMUX initially treated at a Mexican Institute of Social Security (IMSS General Zone Hospital (HGZ during the year 2002. Materials and Methods: This is a transversal study utilizing information from the original source, the HGZ primary-care hospital-facility. We elaborated a registry permit with diverse information sources, and conducted confrontation, followup, and statistical analysis of these sources. Results: Of 6,551 probable occupational accidents treated at the HGZ Emergency Room, we selected 821 cases ascribed to the selected FMUX. We made up three groups according these dictates: Group I = YES, occupational, 35.4% (290; Group II = NO, occupational, 4.6% (38, and Grupo III = not qualified and

  18. Toxic chemical considerations for tank farm releases. Revision 1

    Van Keuren, J.C.

    1995-11-01

    This document provides a method of determining the toxicological consequences of accidental releases from Hanford Tank Farms. A determination was made of the most restrictive toxic chemicals that are expected to be present in the tanks. Concentrations were estimated based on the maximum sample data for each analyte in all the tanks in the composite. Composite evaluated were liquids and solids from single shell tanks, double shell tanks, flammable gas watch list tanks, as well as all solids, all liquids, head space gases, and 241-C-106 solids. A sum of fractions of the health effects was computed for each composite for unit releases based emergency response planning guidelines (ERPGs). Where ERPGs were not available for chemical compounds of interest, surrogate guidelines were established. The calculation method in this report can be applied to actual release scenarios by multiplying the sum of fractions by the release rate for continuous releases, or the release amount for puff releases. Risk guidelines are met if the product is less than for equal to one.

  19. Get Real about Diabetes Prevention

    2007-11-01

    This podcast delivers a diabetes prevention message promoting small steps that can lead to big rewards.  Created: 11/1/2007 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 11/15/2007.

  20. Rape prevention

    Date rape - prevention; Sexual assault - prevention ... Centers for Disease Control and Prevention. Sexual assault and abuse and STDs. In: 2015 sexually transmitted diseases treatment guidelines 2015. Updated June 4, 2015. www.cdc.gov/ ...

  1. Prevent Cyberbullying

    ... Roles Kids Play Other Types of Aggressive Behavior CYBER BULLYING What is Cyberbullying? Prevent Cyberbullying Report Cyberbullying WHO ... More Than a Bystander GET HELP NOW Home > Cyber Bullying > Prevent Cyberbullying CYBER BULLYING What is Cyberbullying? Prevent ...

  2. News/Press Releases

    Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

  3. Accidentes percutáneos con riesgo biológico, producidos por dispositivos de seguridad en la Comunidad de Madrid Percutaneous injuries with biological risk caused by security devices in Madrid Community

    María Clemente Yélamos

    2012-06-01

    Full Text Available Desde la implantación en 2006, de procedimientos seguros y un Sistema de Vigilancia de Accidentes Biológicos en el ámbito sanitario de la Comunidad de Madrid, se viene observando un aumento de los accidentes percutáneos relacionados con la utilización de Dispositivos de Seguridad. Con la finalidad de estudiar los factores contribuyentes a la producción de accidentes con estos nuevos dispositivos, se realiza un estudio descriptivo longitudinal prospectivo de los accidentes notificados a lo largo de 6 meses (2010-2011. Se incluyen 378 accidentes, el 86% afectó a mujeres, siendo la tasa de incidencia en enfermería de 14,3 y entre facultativos de 3,1 (accidentes por mil. Las agujas subcutáneas fueron las más implicadas (25,7%. En el 6,6% de los accidentes se había inactivado intencionadamente su mecanismo de seguridad y solo un 2,6% podría imputarse a un fallo del dispositivo. Entre los factores externos que han podido contribuir destacan "apremio de tiempo/ritmo de trabajo elevado" (46,5% y "realizar la maniobra con posturas incómodas" (31,5%. Las intervenciones para prevenir Accidentes Biológicos deben ser específicas para cada categoría profesional y área de trabajo. Se debe seguir apostando por la introducción de Dispositivos de Seguridad, identificar los factores contribuyentes e implementar acciones individualizadas que minimicen los riesgos.Since the implementation in 2006 of security procedures and a surveillance system of biological accidents in Madrid public health services, an increase of percutaneus accidents related to the use of safety devices has been observed. With the purpose of studying the external factors to the production of accidents with these new devices, there is realized a prospective, longitudinal and descriptive study of the accidents happened throughout six months (2010-2011. 378 accidents are included, 86% happened in women, the incidence rate being 14.3 accidents per thousand in nurses, and 3.1 in

  4. The justice of preventive war

    Stephenson, Henry Alan

    2004-01-01

    Approved for public release; distribution is unlimited In response to the 9/11 attacks and continuing threats of mass-casualty terrorism, the United States has adopted a new security strategy that emphasizes anticipatory actions including preventive war. Prevention, undertaken in the absence of an act of aggression or an imminent threat, is prohibited by modern conceptions of just war and international law. Many critics of the strategy fear that any legitimization of preventive war would e...

  5. A simulation study of dispersion of air borne radionuclides from a nuclear power plant under a hypothetical accidental scenario at a tropical coastal site

    Srinivas, C. V.; Venkatesan, R.

    Meteorological condition in coastal regions is diurnally variable and spatially heterogeneous due to complex topography, land-sea interface, etc. A wide range of dispersion conditions is possible on a given day in the coastal regions. In case of inadvertent accidental situations, though unlikely, it would be necessary to examine the potentially severe case among different dynamically occurring local atmospheric conditions for dispersion and its range of impact around a nuclear power plant for safety analysis. In this context, dispersion of air borne radioactive effluents during a hypothetical accidental scenario from a proposed prototype fast breeder reactor (PFBR) at an Indian coastal site, Kalpakkam, is simulated using a 3-D meso-scale atmospheric model MM5 and a random walk particle dispersion model FLEXPART. A simulation carried out for a typical summer day predicted the development of land-sea breeze circulation and thermal internal boundary layer (TIBL) formation, which have been confirmed by meteorological observations. Analysis of dose distribution shows that the maximum dose for releases from a 100 m stack occurs at two places within 4 km distance during sea breeze/TIBL fumigation hours. Maximum dose also occurred during nighttime stable conditions. Results indicate that, on the day of present study, the highest concentrations occurred during periods of TIBL fumigation rather than during stable atmospheric conditions. Further, the area of impact (plume width at the surface) spreads up to a down wind distance of 4 km during fumigation condition. Simulation over a range of 25 km has shown turning of plume at the incidence of sea breeze circulation and two different dispersion patterns across the sea breeze front. These results are significant in comparison to the expected pattern shown by Gaussian plume model used for routine analysis.

  6. Barrier and operational risk analysis of hydrocarbon releases (BORA-Release). Part II: Results from a case study.

    Sklet, Snorre; Vinnem, Jan Erik; Aven, Terje

    2006-09-21

    This paper presents results from a case study carried out on an offshore oil and gas production platform with the purpose to apply and test BORA-Release, a method for barrier and operational risk analysis of hydrocarbon releases. A description of the BORA-Release method is given in Part I of the paper. BORA-Release is applied to express the platform specific hydrocarbon release frequencies for three release scenarios for selected systems and activities on the platform. The case study demonstrated that the BORA-Release method is a useful tool for analysing the effect on the release frequency of safety barriers introduced to prevent hydrocarbon releases, and to study the effect on the barrier performance of platform specific conditions of technical, human, operational, and organisational risk influencing factors (RIFs). BORA-Release may also be used to analyse the effect on the release frequency of risk reducing measures.

  7. Accidental Hypothermia,

    1988-03-03

    the pulmonary , digestive, and endocrine systems.16� Cardiovascular Cardiovascular responses in hypothermia are vell described. Following an early...decline. Included in this group are patients with hypothalamic lesions and agenesis of the corpus callosum, termed the Shapiro Syndrome.46 1�...Hypothermia with agenesis of the corpus callosum has also been associated with hypercalcemia and status epilepticus.230 Since experimental sectioning of the

  8. Accidental goodness?

    Richter, Anne

    In postmodern capitalist market economies, management of the single organisation is bound to be guided by several rationales, which are in conflict with each other. For some writers this perception leads to the argument, that conceptions of management should strive towards goals beyond the present...

  9. [Accidental falls].

    Inokuchi, Koichi

    2013-06-01

    Falls are common cause of injuries among elderly people, and fractures are the most serious consequence of falls. For seniors, hip fractures are the second major cause of bedridden. The feature and acute care of head injury, spinal cord injury, vertebrae fracture, and hip fracture are described. Just had fracture fixation, the patient can not go back to the original ADL. In order not to become bedridden, both medication and physical examination are important based on the new disease concept of locomotive syndrome. To do so, requires hospital and clinic cooperation. Sufficient cooperation is not currently possible, and spread of liaison service is essential.

  10. CO-releasing molecule (CORM) conjugate systems.

    Kautz, Anna Christin; Kunz, Peter C; Janiak, Christoph

    2016-11-15

    The development of CORMs (CO-releasing molecules) as a prodrug for CO administration in living organisms has attracted significant attention. CORMs offer the promising possibility of a safe and controllable release of CO in low amounts triggered by light, ligands, enzymes, etc. For the targeting of specific tissues or diseases and to prevent possible side effects from metals and other residues after CO release, these CORMs are attached to biocompatible systems, like peptides, polymers, nanoparticles, dendrimers, protein cages, non-wovens, tablets, and metal-organic frameworks. We discuss in this review the known CORM carrier conjugates, in short CORM conjugates, with covalently-bound or incorporated CORMs for medicinal and therapeutic applications. Most conjugates are nontoxic, show increasing half-lives of CO release, and make use of the EPR-effect, but still show problems because of a continuous background of CO release and the absence of an on/off-switch for the CO release.

  11. F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis

    Ray Krishanu

    2009-05-01

    Full Text Available Abstract Background In Drosophila, all the 64 clonally derived spermatocytes differentiate in syncytium inside two somatic-origin cyst cells. They elongate to form slender spermatids, which are individualized and then released into the seminal vesicle. During individualization, differentiating spermatids are organized in a tight bundle inside the cyst, which is expected to play an important role in sperm selection. However, actual significance of this process and its underlying mechanism are unclear. Results We show that dynamic F-actin-based processes extend from the head cyst cell at the start of individualization, filling the interstitial space at the rostral ends of the maturing spermatid bundle. In addition to actin, these structures contained lamin, beta-catenin, dynamin, myosin VI and several other filopodial components. Further, pharmacological and genetic analyses showed that cytoskeletal stability and dynamin function are essential for their maintenance. Disruption of these F-actin based processes was associated with spermatid bundle disassembly and premature sperm release inside the testis. Conclusion Altogether, our data suggests that the head cyst cell adheres to the maturing spermatid heads through F-actin-based extensions, thus maintaining them in a tight bundle. This is likely to regulate mature sperm release into the seminal vesicle. Overall, this process bears resemblance to mammalian spermiation.

  12. Numerical research of a super-large cooling tower subjected to accidental loads

    Li, Yi; Lin, Feng [Department of Building Engineering, Tongji University, Shanghai 200092 (China); Gu, Xianglin, E-mail: gxl@tongji.edu.cn [Department of Building Engineering, Tongji University, Shanghai 200092 (China); Lu, Xiaoqin [Guangdong Electric Power Design Institute, Guangzhou 510660 (China)

    2014-04-01

    With the continued development of nuclear power plants, more and more super-large cooling towers are to be built in China and around the world. For the safe operation of nuclear power plants, research work has been done on the causes of collapse of cooling towers, collapse modes and the secondary disasters caused by the collapse of cooling towers. However, the collapse modes and the ground vibration induced by the collapse of cooling towers subjected to the accidental loads have not been fully understood. This paper has been focused on the modes and mechanisms behavior of the collapse of cooling towers subjected to accidental loads. Meanwhile, prediction of the ground vibration due to the collapse of the cooling towers has also been completed in a parallel project. Using dynamic finite element program LS-DYNA, a 3D finite element model for a super-large cooling tower was developed and the nonlinear material models were incorporated. In this paper, four types of accidental loads were considered to trigger the collapse or local failure of the tower, including vehicle collision, airplane impact, local explosion and missile attack. It was found that vehicle collision, missile attack and small TNT equivalent explosives (2 kg, 20 kg, 200 kg) might result in local failure of the cooling tower, however, the tower can still keep stable. On the other hand, large TNT equivalent explosives (2000 kg, 4500 kg) could cause severe damages in the inclined columns of the cooling tower, and lead to progressive collapse of the entire cooling tower. The two kinds of TNT equivalent explosives caused the same collapse mode while the collapsing duration was different. The airplane impacted at the throat of the cooling tower caused the local failure of shell structure of the tower, and then the progressive collapse of the cooling tower happened due to the gravitational action. The resulting collapse mode was different from that triggered by the local explosion.

  13. Menace of childhood non-accidental traumatic brain injuries: A single unit report

    Musa Ibrahim

    2015-01-01

    Full Text Available Background: Childhood traumatic brain injury (TBI has high rate of mortality and morbidity worldwide. There are dearths of reports from developing countries with large paediatric population on trauma; neurosurgery trauma of nonaccidental origin is not an exemption. This study analysed menace of non-accidental TBI in the paediatric population from our center. Materials and Methods: This is a single unit, retrospective study of the epidemiology of non-accidental TBI in children starting from September, 2008 to March, 2014. The management outcomes of the epidemiology of the non-accidental TBI were analysed. Results: Total of 109 children age range from 0 (intra-natal to 16 years with a mean of 5.8 ± 4.6 years (median, 5 years were enrolled into the study. 34 (31.2% were domestic violence, 26 (23.9% street assaults, 16 (14.7% were due to animal assaults and mishaps, 17 (15.6% fall from heights. Seven (6.4% cases of collapsed buildings were also seen during the period. Four (3.7% industrial accidents and two (1.8% were self-inflicted injuries. There were also three (2.8% cases of iatrogenic TBI out of which two infants (1.8% sustained TBI from cesarean section procedure while one patient (0.9% under general anaesthesia felt from the operation bed resulting to severe TBI. Conclusion: Child abuse, unprotected child labour, parental/care-givers negligence are the main cause of nonaccidental TBI. Human right activists and government agents should be incorporated in curtailing the menace.

  14. Tétano acidental no Estado do Ceará, entre 2002 e 2005 Accidental tetanus in the State of Ceará, between 2002 and 2005

    Alexsandra Rodrigues Feijão

    2007-08-01

    Full Text Available Descrevem-se as características demográficas e clínicas de indivíduos com tétano acidental no Ceará. Analisou-se, retrospectivamente, 131 casos de tétano acidental notificados em hospital de referência estadual entre 2002 e 2005. Destes, a maioria (84,8% ocorreu entre homens e em moradores da zona urbana (93,2%. A faixa etária com maior incidência foi a de 35 a 49 anos (35,2%. História vacinal completa esteve relatada em quatro (3% casos, sendo ferimento perfurocortante o mais observado, e os membros inferiores os mais acometidos. O trismo esteve relacionado a 86,2% dos casos, seguido por contraturas (54,1%. Entre os notificados houve 95,5% confirmados, cujo óbito incidiu em 33 (26,4% pacientes. Conclui-se que o tétano acidental no Ceará atinge a população de maneira expressiva, apesar de ser uma doença imunoprevinível. Urge autoridades e órgãos gestores da saúde programarem estratégias que visem mudanças de políticas públicas relacionadas à cobertura vacinal dos susceptíveis, principalmente adultos.The demographic and clinical characteristics of individuals with accidental tetanus in Ceará are described. This was retrospective analysis of 131 cases of accidental tetanus notified in a state referral hospital between 2002 and 2005. Most of these cases (84. 8% occurred among men and among people living in the urban zone (93. 2%. The age group with highest incidence was between 35 and 49 years old (35. 2%. A complete vaccination history was reported in four (3% cases. Puncturing/cutting wounds were the cause most commonly observed and the legs were the area most affected. Trismus (lockjaw was reported in 86. 2% of the cases, followed by muscle contractions (54. 1%. Among the notified cases, 95. 5% were confirmed and 33 patients (26. 4% died. We conclude that accidental tetanus in Ceará significantly affects the population, in spite of being a disease that is preventable by immunization. The health authorities and health

  15. Bursitis por mercurio tras accidente laboral: a propósito de un caso Bursitis due to Mercury after a work accident: a case report

    Susana Lastras González

    2010-06-01

    Full Text Available Auxiliar de enfermería de 28 años que acude al Servicio de Urgencias porque refiere dolor y dificultad para la movilización en rodilla derecha, tras accidente laboral, hace dos días. Refiere que se resbaló mientras transportaba 32 termómetros de mercurio, rompiéndose éstos sobre su rodilla, creando una pequeña herida, siendo la puerta de entrada del metal. En la radiografía, se objetiva el cuerpo extraño metálico, correspondiente a mercurio, en bursa rotuliana. Tras el diagnóstico, se realizó la extracción de la bursa, recuperándose la trabajadora totalmente tras la intervención. Con este caso clínico que aportamos, queremos conocer los efectos del mercurio en la salud de las personas expuestas a dicho metal, estudiar los errores acontecidos en este accidente laboral, valorando cuáles hubieran sido las medidas de actuación preventiva adecuadas para evitar la repetición de este tipo de accidentes y, por último, reflexionar acerca de la relación beneficio-riesgo del uso del mercurio en aparatos de medición en el ámbito sanitario.A 28-year-old woman, nursing assistant, who attends to emergency service, referring pain and difficulty mobilizing right knee after a work accident two days ago. She relates that slipped while carrying 32 mercury thermometers, breaking them on her knee, creating a small wound, being the gateway to the metal. In the radiograph, we objective a metallic foreign body, corresponding to mercury, in patellar bursa. After the diagnosis, the bursa was extracted, and the worker recovered completely, after surgery. With this case report we bring, we want to know the health effects of mercury in people exposed to this metal, studying the errors occurred in this accident, assessing measures of preventive action that would have been neccesary to preclude recurrence of this type accidents and, finally, think about the risk-benefit balance the use of mercury in measuring devices in healthcare.

  16. Salade malade: malignant ventricular arrhythmias due to an accidental intoxication with Aconitum napellus.

    Weijters, B J; Verbunt, R J A M; Hoogsteen, J; Visser, R F

    2008-01-01

    Intoxication with Aconitum napellus is rare in our regions. Aconite alkaloids can cause ventricular arrhythmia by a prolonged activation of sodium channels. Because the margin of safety is low between the analgesic and toxic dose, intoxication is not rare when Aconite is used in herbal medicine. We present a case in which a 39-year-old male was accidentally intoxicated with Aconite. Even though no antidote or adequate therapy is available he was successfully resuscitated. (Neth Heart J 2008;16:96-9.).

  17. Terapéuticas intervencionistas para el accidente cerebrovascular isquémico

    Rabadán, Alejandra T.; Luciano Sposato; Claudio Mazia

    2010-01-01

    En los últimos 20 años se han desarrollado nuevas opciones para el tratamiento y para la prevención del accidente cerebrovascular (ACV) isquémico, muchas de ellas de carácter intervencionista, tales como la endarterectomía carotídea y la trombolisis intravenosa con activador tisular del plasminógeno. La evidencia científica ha llevado a su difusión y utilización en países desarrollados mientras que en naciones emergentes se observa un retraso en su adopción. Otras modalidades terapéuticas que...

  18. Amputación corporal por accidente de trabajo en auxiliar de enfermería

    Alexander Finol Muñoz; Gloria Ortega Marín; Julián Domínguez Fernández; Johanna Rivero Colina; Manuel Usero Fernández; Miguel Espejo García

    2014-01-01

    Los auxiliares de enfermería son un rango profesional expuesto a múltiples riesgos por las actividades inherentes a su trabajo, expuestos constantemente a sustancias desinfectantes que sin el uso apropiado de equipos de protección individual, puede provocar efectos adversos y lesiones en el trabajador. Caso Clínico: Mujer de 51 años de edad, auxiliar de enfermería, con antecedentes de Diabetes Mellitus tipo I y Síndrome de Túnel Carpiano. Presenta derrame accidental de líquido mientras llenab...

  19. Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.

    Leifert, J A; Bossaller, L; Uhl, M

    2008-11-01

    Accidental intra-arterial injection of drugs is a sporadic complication in i.v. drug addicts. A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg. Severe rhabdomyolysis developed within 5 hours after the injection. Selective arterial catheter angiography showed an acute occlusion of the posterior tibial artery. Combination therapy with i.a. urokinase, i.a. prostaglandines and i.v. anticoagulation resulted in re-opening of the obstructed distal artery and complete cessation of symptoms.

  20. Problems in experimental and mathematical investigations of the accidental thermalhydraulic processes in RBMK nuclear reactors

    Nigmatulin, B.I.; Tikhonenko, L.K. [Engineering Centre (EREC) for Nuclear Plants Safety, Electrogorsk (Russian Federation); Blinkov, V.N. [Aviation Institute, Kharkov (Ukraine)] [and others

    1995-09-01

    In this paper the thermalhydraulic scheme and peculiarities of the boiling water graphite-moderated channel-type reactor RBMK are presented and discussed shortly. The essential for RBMK transient regimes, accidental situations and accompanying thermalhydraulic phenomena and processes are formulated. These data are presented in the form of cross reference matrix (version 1) for system computer codes verification. The paper includes qualitative analysis of the computer codes and integral facilities which have been used or can be used for RBMK transients and accidents investigations. The stability margins for RBMK-1000 and RBMK-1500 are shown.

  1. Orofacial manifestations from accidental exposure to caesium 137 in Goiania, Brazil.

    Gomes, M A; Wascheck, C de C; Scully, C; Almeida, O de P; Bozzo, L

    1990-08-01

    The accidental close exposure of over 200 adults and children to a caesium-137 (137Cs) source in Goiania, Brazil in 1987 produced significant short-term morbidity in about 50 patients, and four deaths within a few weeks. Some 57% of those maximally exposed to radiation, developed orofacial lesions, notably purpura, spontaneous bleeding, ulcers and/or acute candidiasis. These lesions were probably mainly the consequences of depression of bone marrow elements by the radionuclide. Though the oral lesions that may follow iatrogenic exposure to ionizing radiation are well recognized this appears to be the first report on the oral sequelae of a serious radiation accident.

  2. Is Project Management Still an Accidental Profession? A Qualitative Study of Career Trajectory

    Tracey M. Richardson

    2015-02-01

    Full Text Available In this study, the authors used qualitative techniques to look for reoccurring themes related to 87 project managers’ responses to interview questions associated with entry into the field of project management and career progression. The study found that despite the efforts of higher education, professional associations, and their professional development and certifications, the project management remains a destination by accident. Professional project managers do not intend to be project managers but “fall into” the profession. This study provides a conceptual framework for project manager career trajectory that has implications for project management training and mentoring and contributes to the growing literature on the accidental profession.

  3. Patologías mentales derivadas de los accidentes de tránsito

    2008-01-01

    Toda persona que se expone a un hecho traumático puede reaccionar de diversas maneras. En este artículo se revisan los conceptos de algunas enfermedades mentales relacionadas con accidentes de tránsito basadas en las Clasificaciones Nosográfias Internacionales DSM-IV y CIE 10.Any person exposed to a traumatic event can react in different ways. This article checks the concepts of some mental illnesses related to traffic accidents based on the international classifications (DSM-IV and ICD 10).

  4. Patologías mentales derivadas de los accidentes de tránsito

    Ginette Campos Villalobos

    2008-09-01

    Full Text Available Toda persona que se expone a un hecho traumático puede reaccionar de diversas maneras. En este artículo se revisan los conceptos de algunas enfermedades mentales relacionadas con accidentes de tránsito basadas en las Clasificaciones Nosográfias Internacionales DSM-IV y CIE 10.Any person exposed to a traumatic event can react in different ways. This article checks the concepts of some mental illnesses related to traffic accidents based on the international classifications (DSM-IV and ICD 10.

  5. Measurement of accidental coincidences in beta-gamma coincidence counting using non-equal dead times

    Hwang, H Y; Cho, Y H; Byun, J I; Kim, T S; Park, T S; Lee, J M

    2002-01-01

    It is shown that the multi-channel time-scaling (MCTS) method is particularly suitable for the direct measurement of accidental coincidences even if the dead times of the two counting channels are of different length. We prepared five samples, with activities from 900 to 2100 s sup - sup 1. The dead time of the gamma channel was 12 mu s for all measurements, but for the beta channel it varied from 12 to 20 mu s. The true coincidence rates determined by the MCTS method are compared with those obtained by using conventional technique.

  6. Transferencia del aprendizaje motor en pacientes con antecedentes de accidente cerebrovascular: serie de casos

    Karen Castro-Medina; Mayra Pérez-Páez; Fabiola Moscoso-Alvarado; Clarice Tanaka

    2015-01-01

    Antecedentes. La rehabilitación es un proceso de reaprendizaje motor, que mejora el desempeño en términos de adquisición de nuevas habilidades y adaptación o refinamiento de habilidades aprendidas previamente. A pesar de este conocimiento, existen, considerablemente, pocos estudios que describan el aprendizaje motor después de un accidente cerebrovascular (ACV) y la relevancia del mismo en los procesos de rehabilitación y recuperación. Objetivo. Describir la transferencia del aprendizaje moto...

  7. Accidental swallowing of a gold cast crown during orthodontic tooth separation.

    Kharbanda, O P; Varshney, P; Dutta, U

    1995-01-01

    Accidental swallowing of a gold cast crown that became loose after separation with brass wire for orthodontic band placement, is reported. The intervention to remove the ingested crown subsequent to its location in the GI tract on immediate radiographic examination of chest and abdomen included endoscopic examination. Since the crown had past distal to the duodenum it was decided to keep a watch on its movement by daily radiographic examination. The crown passed with excreta on the 5th day uneventfully. Literature on ingestion of foreign bodies of dental origin is reviewed. Possible emergencies and their management is discussed.

  8. A model of neutrino mass and dark matter with an accidental symmetry

    Amine Ahriche

    2015-06-01

    Full Text Available We present a model of radiative neutrino mass that automatically contains an accidental Z2 symmetry and thus provides a stable dark matter candidate. This allows a common framework for the origin of neutrino mass and dark matter without invoking any symmetries beyond those of the Standard Model. The model can be probed by direct-detection experiments and μ→e+γ searches, and predicts a charged scalar that can appear at the TeV scale, within reach of collider experiments.

  9. Comportamiento general de los accidentes provocados por animales venenosos en colombia, 2006-2010

    Rodríguez Vargas, Ariadna Lorena; Rodríguez Buitrago, Javier Roberto; Díaz González, Gonzalo Jair

    2013-01-01

    Objetivo El conocimiento parcial de estadísticas nacionales acerca de accidentalidad por animales venenosos, con distribución geográfica en Colombia, motiva el estudio de dichas circunstancias. El objetivo fue realizar una línea base de los accidentes por animales venenosos reportados de forma telefónica al Centro de Investigación, Gestión e Información Toxicológica de la Universidad Nacional de Colombia (CIGITOX), provenientes de todo el país, y cuyo registro se encontraba en bases de datos ...

  10. The accidental potential of diffractive thinking technologies. Mapping and colouring social differentiation in/of school

    Staunæs, Dorthe; Brown, Rikke; Bjerg, Helle

    This paper presents our joint work with using and developing Donna Haraways concept of thinking technologies for putting research into play in cooperation with practitioners within the field of education. First we shortly present the conceptualization of thinking technologies and why we have found...... this conceptualization useful in our work and cooperation with practitioners. Secondly we present the development of the ‘colour map’ as a specific example of a thinking technology and introduce what we shall coin as the accidental potential of working with research informed thinking technologies on the particular...

  11. Accidents - Policy and Punishment Are there boundar ies to the effectiveness of cr iminal sanctions in preventing accidental conduct?

    Fisher, Alan

    This paper discusses recent and impending changes in Health and Safety law, questions the utility and supposed justification of tougher criminal sanctions and appeals for greater clarity in health and safety law as to what is truly a criminal offence. It also questions the use of the ‘reverse burden of proof’ and warns against unintended consequences if responsible people are made to feel that they are being treated unfairly.

  12. Managing Terrorism or Accidental Nuclear Errors, Preparing for Iodine-131 Emergencies: A Comprehensive Review

    Braverman, Eric R.; Blum, Kenneth; Loeffke, Bernard; Baker, Robert; Kreuk, Florian; Yang, Samantha Peiling; Hurley, James R.

    2014-01-01

    Chernobyl demonstrated that iodine-131 (131I) released in a nuclear accident can cause malignant thyroid nodules to develop in children within a 300 mile radius of the incident. Timely potassium iodide (KI) administration can prevent the development of thyroid cancer and the American Thyroid Association (ATA) and a number of United States governmental agencies recommend KI prophylaxis. Current pre-distribution of KI by the United States government and other governments with nuclear reactors is probably ineffective. Thus we undertook a thorough scientific review, regarding emergency response to 131I exposures. We propose: (1) pre-distribution of KI to at risk populations; (2) prompt administration, within 2 hours of the incident; (3) utilization of a lowest effective KI dose; (4) distribution extension to at least 300 miles from the epicenter of a potential nuclear incident; (5) education of the public about dietary iodide sources; (6) continued post-hoc analysis of the long-term impact of nuclear accidents; and (7) support for global iodine sufficiency programs. Approximately two billion people are at risk for iodine deficiency disorder (IDD), the world’s leading cause of preventable brain damage. Iodide deficient individuals are at greater risk of developing thyroid cancer after 131I exposure. There are virtually no studies of KI prophylaxis in infants, children and adolescents, our target population. Because of their sensitivity to these side effects, we have suggested that we should extrapolate from the lowest effective adult dose, 15–30 mg or 1–2 mg per 10 pounds for children. We encourage global health agencies (private and governmental) to consider these critical recommendations. PMID:24739768

  13. Managing Terrorism or Accidental Nuclear Errors, Preparing for Iodine-131 Emergencies: A Comprehensive Review

    Eric R. Braverman

    2014-04-01

    Full Text Available Chernobyl demonstrated that iodine-131 (131I released in a nuclear accident can cause malignant thyroid nodules to develop in children within a 300 mile radius of the incident. Timely potassium iodide (KI administration can prevent the development of thyroid cancer and the American Thyroid Association (ATA and a number of United States governmental agencies recommend KI prophylaxis. Current pre-distribution of KI by the United States government and other governments with nuclear reactors is probably ineffective. Thus we undertook a thorough scientific review, regarding emergency response to 131I exposures. We propose: (1 pre-distribution of KI to at risk populations; (2 prompt administration, within 2 hours of the incident; (3 utilization of a lowest effective KI dose; (4 distribution extension to at least 300 miles from the epicenter of a potential nuclear incident; (5 education of the public about dietary iodide sources; (6 continued post-hoc analysis of the long-term impact of nuclear accidents; and (7 support for global iodine sufficiency programs. Approximately two billion people are at risk for iodine deficiency disorder (IDD, the world’s leading cause of preventable brain damage. Iodide deficient individuals are at greater risk of developing thyroid cancer after 131I exposure. There are virtually no studies of KI prophylaxis in infants, children and adolescents, our target population. Because of their sensitivity to these side effects, we have suggested that we should extrapolate from the lowest effective adult dose, 15–30 mg or 1–2 mg per 10 pounds for children. We encourage global health agencies (private and governmental to consider these critical recommendations.

  14. Improving the knowledge of environment around French nuclear facilities for better dose assessment and post-accidental management

    Parache, V.; Renaud, P. [Institut de Radioprotection et de Surete Nucleaire - IRSN (France)

    2014-07-01

    and propose a reproducible approach for the evaluation of realistic indicators. Furthermore, these study shows that the data obtained on a nuclear site could apply to a nearby nuclear site, with close agro-climatic conditions. The influence of the types of productions and the agricultural and breeding practices, on the potential contamination of foodstuffs produced locally in accidental situation, led the IRSN to develop summary sheets on the agricultural environment of the nuclear sites. These levels of contamination can be very different according to the period of the year in which occurs the accident. For example, the date of harvest determines if these products will be almost exempt from contamination (so already harvested) or if they will present a maximal contamination. In complement, these sheets give some local contacts which would allow obtaining contextual precision around sensitive dates. These data will also allow elaborating sampling strategies to monitor foodstuffs activities after an accidental release. Based on these knowledge of environmental characteristics and considering that the metrological capacity will be necessarily limited, the monitoring strategies must insure that all foodstuff produced on the whole monitored area are below intervention levels. Document available in abstract form only. (authors)

  15. Health care workers and AIDS: a differential study of beliefs and affects associated with accidental exposure to blood

    Maria Rosa Rodrigues Rissi

    Full Text Available This study aimed to analyze affective and cognitive determinants of the professional work of individuals caring for patients with HIV/AIDS, in view of the risk and/or experience of accidental exposure to blood. We drew on the theoretical-methodological references of Fishbein & Ajzen and Maslow's theory. Fifty health care workers were evaluated using an attitudes questionnaire and a needs and motivations instrument. The research verified differences between answers by health care workers who had never suffered accidents and those who had already experienced accidental exposure to blood. Health care workers did their work activities motivated by the need for self-fulfillment and valued their own performance when they were able to meet the patients' emotional needs. Among health professionals who had never experienced accidental exposure to blood, the predominant beliefs was that patients feel remorse over having expose themselves to HIV. Accidental exposure to blood raises difficulties in personal life. Technical aspects are also associated with the possibility of accidental exposure to blood.

  16. The long-term prediction of return to work following serious accidental injuries: A follow up study

    Sensky Tom

    2011-04-01

    Full Text Available Abstract Background Considerable indirect costs are incurred by time taken off work following accidental injuries. The aim of this study was to predict return to work following serious accidental injuries. Method 121 severely injured patients were included in the study. Complete follow-up data were available for 85 patients. Two weeks post trauma (T1, patients rated their appraisal of the injury severity and their ability to cope with the injury and its job-related consequences. Time off work was assessed at one (T2 and three years (T3 post accident. The main outcome was the number of days of sick leave taken due to the accidental injury. Results The patients' appraisals a of the injury severity and b of their coping abilities regarding the accidental injury and its job-related consequences were significant predictors of the number of sick-leave days taken. Injury severity (ISS, type of accident, age and gender did not contribute significantly to the prediction. Conclusions Return to work in the long term is best predicted by the patients' own appraisal of both their injury severity and the ability to cope with the accidental injury.

  17. Health care workers and AIDS: a differential study of beliefs and affects associated with accidental exposure to blood.

    Rissi, Maria Rosa Rodrigues; Machado, Alcyone Artioli; Figueiredo, Marco Antonio de Castro

    2005-01-01

    This study aimed to analyze affective and cognitive determinants of the professional work of individuals caring for patients with HIV/AIDS, in view of the risk and/or experience of accidental exposure to blood. We drew on the theoretical-methodological references of Fishbein & Ajzen and Maslow's theory. Fifty health care workers were evaluated using an attitudes questionnaire and a needs and motivations instrument. The research verified differences between answers by health care workers who had never suffered accidents and those who had already experienced accidental exposure to blood. Health care workers did their work activities motivated by the need for self-fulfillment and valued their own performance when they were able to meet the patients' emotional needs. Among health professionals who had never experienced accidental exposure to blood, the predominant beliefs was that patients feel remorse over having expose themselves to HIV. Accidental exposure to blood raises difficulties in personal life. Technical aspects are also associated with the possibility of accidental exposure to blood.

  18. Preventing Melanoma PSA (:60)

    2015-06-02

    This 60 second public service announcement is based on the June 2015 CDC Vital Signs report. Skin cancer is the most common form of cancer in the U.S. In 2011, there were more than 65,000 cases of melanoma, the most deadly form of skin cancer. Learn how everyone can help prevent skin cancer.  Created: 6/2/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 6/2/2015.

  19. International collaboration on prevention of shaken baby syndrome - an ongoing project/intervention.

    Foley, Sue; Kovács, Zsuzsanna; Rose, Jenny; Lamb, Robyn; Tolliday, Fran; Simons-Coghill, Martine; Stephens, Amanda; Scheiber, Dóra; Toma, Andrea; Asbóth, Katalin; Kassai, Tamás; Agathonos, Helen; Lopes, Nahara R L; Williams, Lúcia C A; Sahin, Figen; Tasar, Aysin; Sarten, Terry

    2013-11-01

    Caring for young infants can be stressful. Non-accidental brain or head injury (shaken baby syndrome) is a result of parental stress, and a lack of knowledge of how to respond to a crying infant and the dangers of shaking a child. This article demonstrates the value of international collaboration in projects to prevent child maltreatment. It includes reports of prevention of shaken baby syndrome programmes in Australia, Hungary, Greece, Brazil and Turkey.

  20. Pacific Northwest Laboratory monthly activities report, September 1973: Division of Production and Materials Management and Hanford Plant assistance programs

    1973-10-01

    Activities are summarized in the following fields: process development and technology, plutonium trenches, soils, prevention of accidental releases, radiation monitoring, environment, and radiation standards. (DLC)

  1. Symmetry-Guaranteed and Accidental Nodal-Line Semimetals in FCC Lattice

    Kawakami, Takuto

    2016-01-01

    We demonstrate theoretically that nodal-line semimetal (NLS) states can be realized in face-center-cubic (fcc) lattice with orbits belonging to one irreducible representation, such as [$p_x$, $p_y$, $p_z$] and/or [$d_{xy}$, $d_{xz}$, $d_{yz}$]. It is shown that the three orbits are subdivided with respect to the odd- and even-parity upon mirror reflection on high symmetry planes, which yields an analytic expression for the trajectory of NL in momentum space when a tight-binding (TB) model is adopted. It becomes clear that there are two kinds of NLs, a symmetry-guaranteed one around the surface of the first Brillouin zone (BZ), and an accidental one around the BZ center governed by the hopping integrals. As a realization of the idea, we analyze the fcc photonic crystal composed of dielectric spheres by solving the Maxwell's equations. Two symmetry-guaranteed and one accidental NLS photonic states are observed. This provides a good platform to confirm experimentally the existence of topological NLS state, and o...

  2. Outcome of Accidental Exposure Prone to Blood Borne Viral Infections in an Educational Hospital

    Shahnaz Sali

    2016-04-01

    Full Text Available Background: The risk for transmission of blood-borne viruses (BBVs such as Human immunodeficiency virus (HIV, hepatitis B virus (HBV and hepatitis C virus (HCV due to occupational exposure is a major concern in the health care setting.Materials and Methods: This study among 337 health care workers (HCWs accidentally exposed to BBVs was carried out from January 2009 to March 2015. The data were reviewed in labbafinejhad hospital, Tehran, Iran.Results: 4 HCWs had exposure to HBS Ag positive, which HBS antibody titer of them was higher than 10 mlu/ml, 6 HCWs were exposed to HCV seropositive patients underwent laboratory investigations for  HCV-antibody on 4,12, 24 weeks that results were negative. 3 cases had exposure to HIV seropositive patients which received standard antiretroviral post exposure prophylaxis.Conclusion: Timely performance for PEP (Post Exposure Prophylaxis reducing BBVs transmission among HCWs.prophylaxis. Conclusions: Timely performance for  PEP(Post Exposure Prophylaxis reducing BBVs transmission among HCWs.Key words: Outcome; Accidental Exposure; Blood Borne Viral Infections

  3. Cuidados de Enfermería en el Accidente Ofídico

    Lorenzo Hernández, María Piedad

    2013-04-01

    Full Text Available El accidente ofídico supone una emergencia médica que requiere atención médica inmediata, pudiendo provocar la muerte de no realizarse una actuación adecuada precoz. El tratamiento varía según la geografía y características de las serpientes autóctonas, existiendo múltiples protocolos, que en ocasiones resultan contradictorios. El objetivo de este trabajo es realizar el proceso de atención de enfermería en el accidente ofídico, siendo imprescindible poseer un conocimiento integral de las especies peligrosas en España, consecuencias de la mordedura y tratamiento específico. Para la elaboración de este artículo se revisó la bibliografía para poner de manifiesto el plan de actuación y cuidados enfermeros. Con la elaboración de un plan de atención de enfermería individualizado se disminuye el riesgo de secuelas y se proporciona un cuidado y una atención sanitaria de calidad.

  4. Triage and management of accidental laboratory exposures to biosafety level-3 and -4 agents.

    Jahrling, Peter; Rodak, Colleen; Bray, Mike; Davey, Richard T

    2009-06-01

    The recent expansion of biocontainment laboratory capacity in the United States has drawn attention to the possibility of occupational exposures to BSL-3 and -4 agents and has prompted a reassessment of medical management procedures and facilities to deal with these contingencies. A workshop hosted by the National Interagency Biodefense Campus was held in October 2007 and was attended by representatives of all existing and planned BSL-4 research facilities in the U.S. and Canada. This report summarizes important points of discussion and recommendations for future coordinated action, including guidelines for the engineering and operational controls appropriate for a hospital care and isolation unit. Recommendations pertained to initial management of exposures (ie, immediate treatment of penetrating injuries, reporting of exposures, initial evaluation, and triage). Isolation and medical care in a referral hospital (including minimum standards for isolation units), staff recruitment and training, and community outreach also were addressed. Workshop participants agreed that any unit designated for the isolation and treatment of laboratory employees accidentally infected with a BSL-3 or -4 pathogen should be designed to maximize the efficacy of patient care while minimizing the risk of transmission of infection. Further, participants concurred that there is no medically based rationale for building care and isolation units to standards approximating a BSL-4 laboratory. Instead, laboratory workers accidentally exposed to pathogens should be cared for in hospital isolation suites staffed by highly trained professionals following strict infection control procedures.

  5. Plutino 15810 (1994 JR1), an accidental quasi-satellite of Pluto

    Marcos, C de la Fuente

    2012-01-01

    In the solar system, quasi-satellites move in a 1:1 mean motion resonance going around their host body like a retrograde satellite but their mutual separation is well beyond the Hill radius and the trajectory is not closed as they orbit the Sun not the host body. So far, minor bodies temporarily trapped in the quasi-satellite dynamical state have been identified around Venus, Earth, the dwarf planet (1) Ceres, the large asteroid (4) Vesta, Jupiter, Saturn and Neptune. Using computer simulations, Tiscareno and Malhotra have predicted the existence of a small but significant population of minor bodies moving in a 1:1 mean motion resonance with Pluto. Here we show using N-body calculations that the Plutino 15810 (1994 JR1) is currently an accidental quasi-satellite of Pluto and it will remain as such for nearly 350,000 yr. By accidental we mean that the quasi-satellite phase is triggered (or terminated) not by a direct gravitational influence in the form of a discrete close encounter but as a result of a resonan...

  6. Implications for platform re-assessment based on in-service damage resulting from accidental loadings

    Sharp, J.V.; Stacey, A. [Health and Safety Executive, London (United Kingdom); Frieze, P.A.; Nichols, N.W.

    1996-12-01

    Current offshore design codes enable the capacity of structural components to be determined, but the equations apply only to the undamaged state. The ability to assess the performance of such components containing damage has only recently been developed and is important in the re-assessment of structures. In particular knowledge of the performance of members which are dented or bowed as a result of accidental damage is important in establishing the capacity of structures in-service, when for example using pushover analyses. Much research has been taken on the capacity of dented and bowed members. This paper reviews this data and establishes a database using screening criteria. This data is then compared with theoretical predictions from recently developed draft ISO equations. These show that dents and bows can significantly reduce the performance of members. A survey of offshore damage resulting in repairs has shown that 30% of this damage is the result of accidental events such as ship impact and dropped objects. Most damage found to members was in the form of dents, bows and cracks, with member severance in a few cases. The implications of this information for reassessment and offshore inspections are considered.

  7. Accidental phosgene gas exposure: A review with background study of 10 cases

    Arvind Kumar Vaish

    2013-01-01

    Full Text Available Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema. Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome.

  8. Accidental fatal poisoning of a dog by Dieffenbachia picta (dumb cane).

    Loretti, Alexandre Paulino; da Silva Ilha, Marcia Regina; Ribeiro, Rita Elaine Streda

    2003-10-01

    A single case of accidental fatal poisoning by Dieffenbachia picta, (dumb cane) (Araceae) in a 9-y-old female Poodle is described. Clinical signs included severe, locally extensive erosive/ulcerative glossitis accompanied by marked dyspnea of acute onset. The animal did not respond to emergency procedures to relieve severe respiratory distress; fatal asphyxiation ensued from edema of the glottis a few hours after the first clinical signs were observed. According to the owner, the dog had access to a tall, potted dumb cane plant and chewed the thick stem of the plant intensely. The owner did not authorize a necropsy of the animal. The diagnosis of Dieffenbachia picta poisoning was based on the history of accidental consumption of dumb cane and clinical signs. A comparison of this single case with other reports of dumb cane poisoning suggests that dogs poisoned by Dieffenbachia species usually recover uneventfully with conservative management and that death from asphyxiation is a rare but possible consequence of this intoxication. Severe edematous swelling of the glottis with occlusion of the larynx airway passage can occur in those cases in which large amounts of sap are quickly squeezed from the plant during intense chewing. Death would occur if owners do not seek veterinary care immediately and if emergency procedures are not instituted on time.

  9. Historical Doses from Tritiated Water and Tritiated Hydrogen Gas Released to the Atmosphere from Lawrence Livermore National Laboratory (LLNL). Part 6. Summary

    Peterson, S

    2007-09-05

    Throughout fifty-three years of operations, an estimated 792,000 Ci (29,300 TBq) of tritium have been released to the atmosphere at the Livermore site of Lawrence Livermore National Laboratory (LLNL); about 75% was tritium gas (HT) primarily from the accidental releases of 1965 and 1970. Routine emissions contributed slightly more than 100,000 Ci (3,700 TBq) HT and about 75,000 Ci (2,800 TBq) tritiated water vapor (HTO) to the total. A Tritium Dose Reconstruction was undertaken to estimate both the annual doses to the public for each year of LLNL operations and the doses from the few accidental releases. Some of the dose calculations were new, and the others could be compared with those calculated by LLNL. Annual doses (means and 95% confidence intervals) to the potentially most exposed member of the public were calculated for all years using the same model and the same assumptions. Predicted tritium concentrations in air were compared with observed mean annual concentrations at one location from 1973 onwards. Doses predicted from annual emissions were compared with those reported in the past by LLNL. The highest annual mean dose predicted from routine emissions was 34 {micro}Sv (3.4 mrem) in 1957; its upper confidence limit, based on very conservative assumptions about the speciation of the release, was 370 {micro}Sv (37 mrem). The upper confidence limits for most annual doses were well below the current regulatory limit of 100 {micro}Sv (10 mrem) for dose to the public from release to the atmosphere; the few doses that exceeded this were well below the regulatory limits of the time. Lacking the hourly meteorological data needed to calculate doses from historical accidental releases, ingestion/inhalation dose ratios were derived from a time-dependent accident consequence model that accounts for the complex behavior of tritium in the environment. Ratios were modified to account for only those foods growing at the time of the releases. The highest dose from an

  10. Caregivers' voices: The experiences of caregivers of children who sustained serious accidental and non-accidental head injury in early childhood.

    Wharewera-Mika, Julie; Cooper, Erana; Kool, Bridget; Pereira, Susana; Kelly, Patrick

    2016-04-01

    Head injury is a leading cause of mortality and acquired neurological impairment in children. Head-injured children may have neurobehavioural deficits that persist for years following injury. Head injury can result in significant and persistent caregiver burden, including mental health issues, family stress and disorganisation, and unmet social and healthcare service needs. Few studies have examined the healthcare and social service needs of children and their families following head injury sustained at an early age. This qualitative study aims to describe the experiences of caregivers of children who sustained a serious head injury (particularly non-accidental head injury) before the age of 2 years. Caregivers were interviewed up to 15 years following the initial injury. Semi-structured interviews with 21 caregivers of 15 children (aged 3-15 years at the time of interview) were completed. Thematic analysis of interview data generated three key themes: impact, support and information. The study's findings reveal the broad impact of serious childhood head injury on caregivers, specifically the significant distress and burden brought about through lack of information, challenges in accessing support and inconsistent care. Recommendations for developing a quality 'model of care' and improving ease of access to supports for caregivers are provided.

  11. Drowning Prevention

    ... Listen Español Text Size Email Print Share Drowning Prevention: Information for Parents Page Content Article Body Drowning ... in very cold water for lengthy periods. Drowning Prevention: Know the Warning Signs These signs may signal ...

  12. Salmonella Prevention

    ... FDA) USDA Food Safety and Inspection Service Follow Salmonella RSS Prevention Recommend on Facebook Tweet Share Compartir Quick Tips for Preventing Salmonella Cook poultry, ground beef, and eggs thoroughly. Do ...

  13. Dengue Prevention

    ... there are no specific medications to treat a dengue infection. This makes prevention the most important step, and prevention means avoiding ... If someone in your house is ill with dengue, take extra precautions to prevent mosquitoes from biting the patient and going on ...

  14. Prescripción facilitada de drogas antihipertensivas y disminución de la muerte prematura por accidente cerebrovascular

    Javier Mariani; Marina Ridao; Gabriel González; Mauricio Monsalvo; Alejandro Macchia

    2016-01-01

    Introducción: Desde 2003, el programa Remediar (+Redes) distribuye gratuitamente medicación antihipertensiva. Durante este período, la mortalidad por accidente cerebrovascular disminuyó, aunque con inequidades entre grupos socioeconómicos. Objetivos: Evaluar la asociación entre la mortalidad por accidente cerebrovascular y la provisión de fármacos antihipertensivos. Estudiar la posible interacción entre los efectos de los antihipertensivos sobre la mortalidad y el nivel socioeconómico. ...

  15. Los accidentes coronarios de la terapéutica electro-convulsivante. su patogenia y su prevención

    Jiménez Arango, Alejandro; Hakim Dow, Salomón

    2011-01-01

    a) Se plantea el problema de la aparición de accidentes coronarios en las aplicaciones de electro-choque y se hace un recuento de los casos referidos en la literatura.b) Se presentan las historias de dos casos clínicos: unos de insuficiencia coronaria aguda transitoria y otro de infarto del miocardio, consecutivos a aplicaciones de electro-choque.c) Se propone una explicación fisio-patológica de tales accidentes considerando: 1° La influencia de las lesiones coronarias antiguas. 2° La variabi...

  16. Muerte prematura por accidente cerebrovascular y condición socioeconómica en la Argentina

    Mauricio Monsalvo; Anabel Fernández Prieto; Alejandro Macchia

    2016-01-01

    Introducción: La asociación entre mortalidad por accidente cerebrovascular y el nivel socioeconómico está escasamente descripta en Argentina. Objetivos: Describir la evolución temporal de la mortalidad por accidente cerebrovascular y su asociación con el nivel socioeconómico en Argentina entre 2000 y 2011. Material y métodos: Se realizó un estudio ecológico longitudinal. La mortalidad se cuantificó mediante tasas estandarizadas por edad y sexo, y el nivel socioeconómico mediante quint...

  17. 中山市78例婴儿意外伤害特点分析%CHARACTERISTICS OF 78 CASES OF ACCIDENTALLY INJURED INFANTS IN ZHONGSHAN CITY

    莫庆仪; 付四毛; 张泉山

    2014-01-01

    目的:分析中山市博爱医院2012~2013年收治的78例婴儿意外伤害的特点,为本市婴儿意外伤害的预防提供建议。方法对78例婴儿意外伤害的临床特点及不同伤害类型相关因素进行回顾性分析,并在R统计环境中进行统计学分析。结果8月以上月龄的婴儿(P=0.023)和外地户籍家庭的婴儿(P<0.001)更容易发生意外伤害。约79.5%的婴儿意外伤害发生在家中(P<0.001)。烧/烫伤(28.2%)、异物吸入(28.2%)及交通伤害(17.9%)为最常见的原因(P<0.001)。发生异物吸入的患儿有36.4%(4/11)未在当天进入医院接受治疗。结论监护人在照管婴儿时,不可因婴儿月龄较大而放松警惕。城市和农村家庭都应充分注意预防婴儿意外伤害,而外地户籍者可能更需要加强对婴儿的照管。家中活动时,尤其应警惕热液所致烧/烫伤及喂食相关的异物吸入,后者更应引起足够的重视并及时就诊。%Objective: To investigate characteristics of 78 cases of accidentally injured infants in Zhongshan Bo’ai Hospital, and provide some advices in preventing such injuries locally. Methods:Clinical characteristics and injury-type related factors were analyzed retrospectively, and statistical calculations were carried out in the R environment. Results:Accidental injury is more prone in infants older than 8 months (P=0.023) or those whose parents come from other places (P<0.001). Around 79.5%of the cases happened at home (P<0.001). The most (P<0.001) common types of accidental injury in infants were burn (28.5%), inhale of foreign body (28.2%), and traffic accident (17.9%). As many as 36.4%of infants who suffered from inhaled foreign bodies did not receive treatment in time. Conclusions: Guardians must pay attention to accidental injuries to infants even though it is old enough, no matter they lives in urban or rural area. Not-native guardians might need to pay more attention. When

  18. Zegerid--immediate-release omeprazole.

    2005-04-11

    The FDA has approved marketing of Zegerid powder for oral suspension (Santarus), an immediate-release formulation of the proton-pump inhibitor (PPI) omeprazole (Prilosec, and others). All other oral PPIs are delayed-release, enteric-coated formulations designed to prevent degradation of the drug by gastric acid. Each 20- or 40-mg packet of Zegerid contains 1680 mg sodium bicarbonate, which protects the drug from gastric acid degradation. A dose of Zegerid contains 460 mg of sodium, which may be excessive for some patients. Zegerid is the first oral PPI to be approved by the FDA for reduction of risk of upper GI bleeding in critically ill patients. The drug may be useful for patients who are unable to swallow and have nasogastric (NG) tubes in place. Zegerid cost $70.00 for 14 days' treatment, compared to less than $10 for 14 tablets of Prilosec OTC.

  19. 淮安市淮安区2012-2015年居民意外伤害死因分析%Death Analysis of Accidental Injury of Residents in Huaian District in Hua-ian from 2012 to 2015

    崔永生; 陈震

    2016-01-01

    Objective To know the epidemic characteristics and change trend of accidental injury of residents in Huaian district in Huaian and provide scientific basis for making the preventive and control measures. Methods The injury death monitoring data in the death registration reporting system from 2012 to 2015 were analyzed by the descriptive epidemiolog-ical method. Results The average death rate of resident injury in Huaian district from 2012 to 2015 was 127.1/100 thou-sand, ranking No.3, the top 5 of injury death were in turn traffic accident, drowning, committing suicide, accidental falling and accidental poisoning, and the accidental injury death in male was higher than that in female. Conclusion The acciden-tal injury is one of the major deaths of residents in Huaian district, and the traffic accident is the first of accidental injury, and we should pay attention to it and adopt effective intervention measures to reduce the accidental injury death of resi-dents, which is of major significance.%目的:了解淮安市淮安区居民意外伤害的流行特征和变化趋势,为制定预防控制措施提供科学依据。方法采用描述性流行病学方法2012—2015年死因登记报告系统中意外伤害的死亡监测资料进行分析。结果2012—2015年淮安区居民伤害平均死亡率为12.71/10万,在死因顺位中排第3位。伤害死亡的前五位依次为交通事故、溺水、自杀、意外跌落和意外中毒,意外伤害死亡男性高于女性。结论意外伤害是淮安区居民的主要死因之一,交通事故是意外伤害之首,应引起重视,采取有效的干预措施对减少居民意外伤害死亡有重要意义。

  20. Toxics Release Inventory (TRI)

    U.S. Environmental Protection Agency — The Toxics Release Inventory (TRI) is a dataset compiled by the U.S. Environmental Protection Agency (EPA). It contains information on the release and waste...

  1. Urban "accidental" wetlands mediate water quality and heat exposure for homeless populations in a desert city

    Palta, M.

    2015-12-01

    In urban settings where humans interact in complex ways with ecosystems, there may be hidden or unanticipated benefits (services) or harm (disservices) conferred by the built environment. We examined interactions of a highly vulnerable population, the homeless, with urban waterways and wetlands in the desert city of Phoenix, Arizona, U.S.A. Climate change models project increases in heat, droughts, and extreme floods for the southwestern U.S. These projected changes pose a number of problems for sustainability and quality of future water supply, and the ability of human populations to mitigate heat stress and avoid fatalities. Urban wetlands that are created "accidentally" (by water pooling in abandoned areas of the landscape) have many structural (e.g., soils and hydrology) and functional (e.g., high denitrification) elements that mimic natural, unaltered aquatic systems. Accidental wetland systems in the dry bed of the Salt River, fed by storm and waste water from urban Phoenix, are located within economically depressed sections of the city, and show the potential for pollutant and heat mitigation. We used a mixed-method socio-ecological approach to examine wetland ecosystem functions and the ways in which homeless populations utilize Salt River wetlands for ecosystem services. Interviews and trash surveys indicated that homeless people are accessing and utilizing the wetlands as a source of running water, for sanitary and heat mitigation services, and for recreation and habitation. Environmental monitoring demonstrated that the wetlands can provide a reliable source of running water, nutrient and pathogen removal, heat mitigation, and privacy, but they may also pose a health risk to individuals coming in contact with the water through drinking or bathing. Whether wetlands provided a net benefit vs. harm varied according to site, season, and particular service, and several tradeoffs were identified. For example, heat is highest during the summer storm season

  2. Accidental Thawing of Embryos, Cryopreserved for Transfer. Two Italian cases, Milan and Rome.

    Busardò, Francesco P; Vergallo, Gianluca Montanari; Turillazzi, Emanuela; Bolino, Giorgio; Vullo, Annamaria; Frati, Paola

    2016-01-01

    The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes concerning the accidental thawing of embryos, which have been cryopreserved for transfer. Two Italian cases (the Milan and the Rome cases) are here reported: the Milan case involves a couple undergoing artificial insemination. Three eggs were collected for insemination and two of them had been fertilized. During the night of 8/9 May 2007 a short circuit occurred, resulting in an electricity blackout, which caused the loss of the embryos in culture, which should have been transferred to the woman's uterus on 9 May. The couple applied for damage compensation from the hospital following the loss of the embryos. The case went to Court and the result was a judgment issued by the Milan civil court, which recognized that the centre was to blame for irreparable damage to the embryos. The Rome case, involves two couples (A and B) affected by sterility who applied to an authorized public centre to undergo an ART program. Following the medical procedures, two of the embryos produced were transferred to the woman in couple A and five were frozen, whereas three embryos produced by couple B were transferred to the uterus of the woman and six eggs were cryopreserved in the centre. Two years after the procedure there was an electricity blackout, and the backup electricity generator failed to function, causing the loss of the gametes and the embryos cryopreserved in the centre. Legal proceedings begun by the couples to obtain compensation for damages are still underway. The above reported cases have significantly intensified the bioethical debate on the lawfulness of such practices and on the fate of the cryopreserved embryos, at the same time opening new frontiers in

  3. ACUTE ACCIDENTAL POISONING IN CHILDREN: A HOSPITAL-BASED RETROSPECTIVE STUDY

    Kameshore

    2014-10-01

    Full Text Available INTRODUCTION: Acute accidental poisoning in children is a big problem anywhere in the world. Studies done elsewhere in India showed a wide range of incidence of the problem. Hence, it was felt important to study its magnitude and associated characteristics as of now. OBJECTIVE: The current study was taken up to know the magnitude among children admitted in JNIMS, Imphal which is a newly established medical institute and also to study the characteristics like age, gender, type of poison, duration of hospital-stay and outcome of the cases. MATERIALS & METHODS: Retrospective data of all acute accidental poisoning cases among children admitted in the Pediatrics Ward, JNIMS, Imphal during the period July 2008 - December 2013 were analyzed by using descriptive statistics. RESULT: Of all the 13,663 children admitted, 148 cases were because of acute accidental poisoning giving an incidence rate of 1.08%. The male is to female ratio was 1.31:1. The last three years of the study period showed a slightly increasing trend in the incidence. Children aged 1-4 years were the most commonly affected (65.54%. Kerosene oil was by far the commonest (42% of all the poisonous substances consumed. Food poisoning, poisoning with organic compounds, poisoning with medicinal drugs and poisoning with corrosives comprised 21%, 12%, 9% and 8% respectively of all the cases. There was no mortality. DISCUSSION: The incidence rate of 1.08% as found out from the current study was on the lower side as compared to reports of previous studies done in other parts of the country. Yet, it was two-fold of the incidence reported from RIMS which is situated in the same State. Parental negligence in storing poisonous substances in the household was implicated. They need to be made aware for keeping harmful poisonous substances in safe places out of the reach of children. CONCLUSION: Community-based studies are recommended for estimating more accurately the magnitude of the problem in the

  4. NSAIDs and the risk of accidental falls in the elderly: a systematic review.

    Hegeman, Judith; van den Bemt, Bart J F; Duysens, Jacques; van Limbeek, Jacques

    2009-01-01

    Accidental falls, especially those occurring in the elderly, are a major health and research topic nowadays. Besides environmental hazards and the physiological changes associated with aging, medication use (e.g. benzodiazepines, vasodilators and antidepressants) and polypharmacy are significant risk factors for falling as well. Exposure to NSAIDs has been associated with accidental falls too, although information on this area is less consistent. Therefore, the main goal of this review is to provide an updated overview of all the evidence published on the risk of falling due to NSAID use thus far. A systematic literature search for material published between 1966 and March 2008 in PubMed, EMBASE, the Cochrane Database of Systematic Reviews, Exerpta Medica, Current Contents and Science Citation Index was combined with a check of the reference lists of all the retrieved articles. Validity and data extraction of the eligible articles was assessed by adapted criteria, based on checklists that were originally developed to assess case-control or cohort studies. From the 16 selected articles, two studies were rejected because of clustering of data and one article was excluded because it contained the same data as that in one of the included articles. None of the articles retrieved included a randomized controlled trial. The remaining 13 studies all showed some lack in completeness of their statistical methods, and much variation in reporting of effects. The overall mean age was high in the study populations, leaving the results to be poorly generalizable to a larger population and other age categories. Despite these imperfections, all studies showed an increased risk of falling due to NSAID use (four significant, nine non-significant), and a tendency towards an increased fall risk with NSAID exposure could be noted. The results shown in the present review suggest that an increased risk for accidental falls is probable when elderly individuals are exposed to NSAIDs. The

  5. Dynamic Data-Driven Event Reconstruction for Atmospheric Releases

    Kosovic, B; Belles, R; Chow, F K; Monache, L D; Dyer, K; Glascoe, L; Hanley, W; Johannesson, G; Larsen, S; Loosmore, G; Lundquist, J K; Mirin, A; Neuman, S; Nitao, J; Serban, R; Sugiyama, G; Aines, R

    2007-02-22

    Accidental or terrorist releases of hazardous materials into the atmosphere can impact large populations and cause significant loss of life or property damage. Plume predictions have been shown to be extremely valuable in guiding an effective and timely response. The two greatest sources of uncertainty in the prediction of the consequences of hazardous atmospheric releases result from poorly characterized source terms and lack of knowledge about the state of the atmosphere as reflected in the available meteorological data. In this report, we discuss the development of a new event reconstruction methodology that provides probabilistic source term estimates from field measurement data for both accidental and clandestine releases. Accurate plume dispersion prediction requires the following questions to be answered: What was released? When was it released? How much material was released? Where was it released? We have developed a dynamic data-driven event reconstruction capability which couples data and predictive models through Bayesian inference to obtain a solution to this inverse problem. The solution consists of a probability distribution of unknown source term parameters. For consequence assessment, we then use this probability distribution to construct a ''''composite'' forward plume prediction which accounts for the uncertainties in the source term. Since in most cases of practical significance it is impossible to find a closed form solution, Bayesian inference is accomplished by utilizing stochastic sampling methods. This approach takes into consideration both measurement and forward model errors and thus incorporates all the sources of uncertainty in the solution to the inverse problem. Stochastic sampling methods have the additional advantage of being suitable for problems characterized by a non-Gaussian distribution of source term parameters and for cases in which the underlying dynamical system is non-linear. We initially

  6. Vivenciando el trabajo de los buzos mariscadores que han sufrido un accidente Living the work of seafood divers who have suffered an accident

    Irene Aguilar Gallardo

    2005-11-01

    Full Text Available El objetivo de esta investigación es describir las vivencias del trabajo de buzos mariscadores que viven en caletas de pescadores de las provincias de Llanquihue y Palena y que hubieran tenido un accidente durante la práctica de su oficio, en el contexto de su significado cultural. Para este estudio se utilizó la investigación cualitativa, optando por el método etnográfico de Spradley (1979-1980. La recolección de los datos se realizó mediante la Observación Participante y la Entrevista Etnográfica. Al validar los dominios, taxonomías y temas surge el tema central que es: describiendo vivencias de su oficio. En él se destacan ideas y percepciones similares en este grupo humano respecto a la vida y al trabajo que realizan y diferencias en relación a las razones para continuar en el oficio para algunos, porque les apasiona y para otros porque se sienten obligados por ser ésta la única opción que les permite la subsistencia a ellos y su grupo familiar. El subtema que emerge es "a mayor profundidad está la mercancía", de éste se generan los dominios de lo que sucede con el buzo: los riesgos de trabajar a mayor profundidad, las causas de los accidentes, las consecuencias y secuelas, las percepciones durante la rehabilitación, las formas que adoptan para prevenir accidentes y las expectativas para el futuro. Los datos obtenidos del estudio permitirán al equipo de salud ampliar conceptos y conocimientos de experiencias, vivencias y significado que los buzos le otorgan al trabajo en su contexto cultural. Lo anterior, contribuirá a facilitar el proceso de interacción con este grupo humano y realizar acciones de salud concordantes con su modo de sentir y pensar, uniendo esfuerzos para la prevención, promoción, recuperación y rehabilitación de su salud.The objective of this research is to describe the work experiences of the shellfish divers who belong to the province of Llanquihue and Palena who have suffered and accident during

  7. Estrategias de prevención y vigilancia sobre el uso de sustancias ilícitas y su impacto en los costos de accidentes en conductores de carga pesada en México Estratégia de prevenção e vigilância sobre o consumo de sustâncias ilícitas e os custos dos acidentes em motoristas de carga pesada, no México Prevention and monitoring strategies on the use of illicit substances and accidents and costs in heavy load drivers in Mexico

    Eduardo Puente-Rodríguez

    2011-06-01

    Full Text Available Las colisiones de tránsito son uno de los grandes problemas de Salud Pública en el mundo, los impactos afectan áreas de la salud, económica y social. Los conductores de carga pesada fueron el objeto de este estudio. Se tuvo por objetivo identificar los costos de accidentes después de aplicar estrategias de control de consumo de sustancias lícitas e ilícitas en conductores de transporte de carga pesada. Se realizó un estudio correlacional retrospectivo de 2004 a 2006. La población a la que se aplicó el programa disminuyó el número de accidentes en 15%, y el costo por daños por colisión en 24%. Se concluye que estudios de esta naturaleza son importantes para implantación de programas orientados a modificar la conducta cuidado y seguimiento de la salud de los conductores profesionales.Os acidentes de trânsito constituem um dos maiores problemas de saúde pública no mundo, e seus impactos afetam as áreas de saúde, econômica e social. O motorista de carga pesada é o objeto do presente estudo. O objetivo foi identificar os custos de acidentes ao aplicar estratégias de controle, frente ao uso de drogas lícitas e ilícitas, em motoristas de carga pesada. Como metodologia deste estudo foi usada a pesquisa retrospectiva correlacional, conduzida de 2004 a 2006. Com base no censo, na população participante do programa houve diminuição do número de acidentes de 15% e dos custos por danos causados por colisão de 24%. Conclui-se que estudos dessa natureza são importantes para implantação de programas direcionados à modificação de comportamentos e monitorização do cuidado de saúde a motoristas profissionais.Road crashes are one of the largest public health problems in the world. Impacts affect Health, Economic and Social areas. This study focuses on heavy load drivers. The goal is to identify the costs of accidents to implement control strategies for licit and illicit substance consumption in heavy load drivers. Method: a

  8. ARAC Modeling of the Algeciras, Spain Steel Mill CS-137 Release

    Vogt, P J; Pobanz, B M; Aluzzi, F J; Baskett, R L; Sullivan, T J

    1999-05-01

    On 12 June 1998, the Atmospheric Release Advisory Capability (ARAC) learned from news reports about the accidental release of cesium-137 from a steel mill near Algeciras, Spain. We used the U.S. Navy Operational Global Atmospheric Prediction System (NOGAPS) gridded data for meteorological input into our diagnostic models. To better resolve near-release location and coastal meteorological conditions, we blended four days of WMO surface and upper air observations with the gridded data. Our calculations showed the plume initially traveled eastward over the Mediterranean Sea, turned northward into central Europe, and was split by the Alps. We determined the timing and amount of cesium released by fitting our modeled air concentrations to the available set of measurements. Accuracy statistics from a small set of ratios of measured to computed air concentrations paired in space and time were similar to those achieved from larger data sets in previous ARAC model evaluation studies on the continental scale.

  9. Prevalencia de foramen oval permeable en pacientes con accidente cerebrovascular o accidente isquémico transitorio criptogénicos

    Alejandro E. Contreras

    2009-01-01

    Full Text Available RESUMENIntroducciónEl foramen oval permeable (FOP se encuentra en alrededor de la cuarta parte de la población general. Pese a que su hallazgo no tiene repercusiones clínicas y no requiere tratamiento,se reconoce como una posible causa de accidente cerebrovascular (ACV criptogénico.ObjetivoConocer la prevalencia de FOP en pacientes estudiados por ACV o crisis isquémicas transitorias(CIT criptogénicos.Material y métodosSe analizaron retrospectivamente los ecocardiogramas transesofágicos de pacientes con ACVo CIT criptogénicos derivados para la evaluación de fuentes embolígenas. Se definió FOP alpasaje de una o más burbujas dentro de los tres primeros latidos luego de la opacificación dela aurícula derecha. Se definió aneurisma del septum interauricular (ASA a la excursióndel septum hacia la aurícula derecha o izquierda de 10 mm o más.ResultadosSe evaluaron 43 pacientes, edad promedio 59,6 ± 16,9 años, 41,9% mujeres. Se halló FOPen 13 pacientes (30,2% - IC 95% 15% a 44%, de los cuales 7 (16,3% del total de la poblaciónpresentaban FOP grande. Hubo 6 casos de ASA (14%, todos asociados con FOP y en 4 deellos (66% el FOP era grande.ConclusionesLa prevalencia de FOP en pacientes con ACV o CIT criptogénicos es del 30% y en uno decada tres de ellos se asocia con aneurisma del septum interauricular.REV ARGENT CARDIOL 2009;77:493-495.

  10. Multiple simultaneous intracerebral hemorrhages following accidental massive lumbar cerebrospinal fluid drainage: Case report and literature review

    Ruiz-Sandoval Jose

    2006-01-01

    Full Text Available Multiple simultaneous intracerebral hemorrhages (ICH are uncommon. We report the case of an 80-year-old woman with previous diagnosis of normal pressure hydrocephalus and who was brought to our hospital with altered mental status and urinary incontinence. Medical history of hypertension, hematological disorders or severe head trauma was absent. Platelet count and coagulation profile were unremarkable. An initial head computed tomography (CT showed sulcal enlargement and ventricular dilatation, but no evidence of ICH. A tap test indicated as a guide to case selection for shunt surgery accidentally resulted in cerebrospinal fluid (CSF overdrainage. The patient presented sudden neurological deterioration, with sluggishly responsive pupils and generalized tonic-clonic seizures. A new head CT demonstrated multiple supra and infratentorial ICH. The patient became comatose and had a fatal course. Hence, CSF overdrainage may either cause or precipitate multiple simultaneous ICHs, affecting both the infratentorial and supratentorial regions.

  11. Accidental permutation symmetries as a test for Grand Unification: the supersymmetric $SU(5)$ case

    Fichet, Sylvain

    2016-01-01

    Unification of matter fields implies the existence of accidental permutation symmetries, which potentially remain immune to large quantum corrections up to the TeV scale. We investigate the case of a supersymmetric $SU(5)$ grand unified theory, where such a permutation symmetry is present in the up-type squark sector. We present a variety of tests allowing to challenge the $SU(5)$ hypothesis based on the observation of squarks at the LHC. These tests appear as relations among observables involving flavour-violating or chirality-flipping decays of squarks. Moreover, they rely on top-polarimetry and charm-tagging. As an example, we discuss the application to the scenario of Natural Supersymmetry, while more examples can be found in the related journal publications.

  12. 'Battered pets': features that raise suspicion of non-accidental injury.

    Munro, H M; Thrusfield, M V

    2001-05-01

    A study of veterinarians' perceptions, and experience, of non-accidental injury (NAI) to pets was undertaken using an anonymous questionnaire distributed to a random sample of 1000 small animal practitioners in the UK. NAI was acknowledged by 91.3 per cent (95 per cent confidence interval, 88.2 to 93.9 per cent) of the 404 respondents who returned questionnaires, of whom 48.3 per cent (95 per cent confidence interval, 43.4 to 53.1 per cent) had either suspected or seen NAI. Four hundred and forty-eight cases were documented, predominantly in dogs (243) and cats (182). Factors either raising suspicion, or facilitating recognition, of NAI included: implication of a particular person, features of the history, referral agency involvement, behaviour of the owner and/or the animal, nature of the injuries, and socioeconomic class of owners. Additionally, sexual abuse and suspected cases of Munchausen syndrome by proxy were recorded.

  13. Cardiac thrombus developing after an accidental high-voltage electric shock in a child.

    Akın, Alper; Bilici, Meki; Demir, Fikri; Gözü Pirinççioğlu, Ayfer; Yavuz, Celal

    2015-01-01

    Electric shock is a condition that may affect various organ systems and potentially cause death. Cardiac findings vary from asymptomatic mild injury to fatal myocardial involvement. Herein we present a five-year-old boy with a cardiac thrombus developing after an accidental electrical shock. Cardiac arrhythmias and evidence of ischemia have been reported after electric shock; we were, however, unable to identify an earlier case report of intracardiac thrombosis related to electric shock. Findings such as elevated cardiac enzymes and systolic dysfunction, which indicate myocardial damage following electric shock, were present in our patient. We think that the cardiac thrombus might have resulted from the myocardial damage and the slowed intracardiac blood flow related to systolic dysfunction. As the thrombus was thought to have been formed through known mechanisms, it was treated traditionally. However, further data regarding the etiology and management of such thrombi is needed.

  14. El seguro de accidentes personales en Colombia y su visión jurisprudencial.

    Fabio Bonilla

    2003-01-01

    Full Text Available Un recorrido a través de 25 años de jurisprudencia colombiana, permite al autor exponer y comentar la posición de la jurisprudencia nacional en torno a la definición de accidente y la distribución de la carga probatoria en las pólizas de seguro de riesgos accidentales. Se destaca este artículo por poner de presente el contraste existente entre el derecho colombiano y el de los países europeos en lo referido a la definición del riesgo en este tipo de pólizas, con base en requerimientos de intencionalidad por parte del tercero que con su intervención da lugar al siniestro.

  15. Accidental $\\xi$-scaling as a signature of nuclear effects at x $>$ 1

    Benhar, O

    1995-01-01

    We propose an interpretation of the \\xi-scaling behavior of nuclear structure functions observed at Bjorken x>1 and Q^2 \\lesssim 4 \\, {\\rm (GeV/c)^2}. We show that at \\xi \\gtrsim 1, \\xi-scaling might arise accidentally because of the approximate cancellation of two different Q^2-dependent effects, namely Final State Interactions and the effects implicit in the choice of the scaling variable \\xi. We provide a new convolution formula for the nuclear structure function in terms of \\xi and make predictions for the kinematical regions where Final State Interactions are expected to be small and the suggested balancing of scaling violations is expected to break down. Our analysis is aimed at the final goal of clarifying the range of applicability of local duality ideas in nuclei.

  16. Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation, January 1983-December 1984

    Adams, W.H.; Engle, J.R.; Harper, J.A.; Heotis, P.M.; Scott, W.A.

    1986-01-01

    March 1, 1984, was the 30th anniversary of the Bravo thermonuclear test that resulted in the accidental exposure of the populations of Rongelap and Utirik atolls to radioactive fallout. The chronicling of the medical events resulting from that exposure is continued in this report, which covers the period from January 1983 through December 1984. An updated listing of all relevant publications from the Medical Department Brookhaven National Laboratory, is presented in the Reference Section. Thirty years of observation continue to show no detectable increase in mortality in the exposed population as a result of that exposure. The survival curves of the high-exposure Rongelap group, the low-exposure Utirik population, and an unexposed group of Rongelap people matched by age and sex to the exposed Rongelap group in 1957 continue to be similar. 89 refs., 2 figs., 6 tabs.

  17. Two viable large scalar multiplet models with an accidental Z2 symmetry

    Earl, Kevin; Logan, Heather E; Pilkington, Terry

    2013-01-01

    Models in which the Higgs sector is extended by a single scalar electroweak multiplet Z will possess an accidental global Z2 symmetry if Z has isospin T=5/2 (sextet) or 7/2 (octet) and carries the same hypercharge as the Standard Model Higgs doublet. This Z2 symmetry keeps the lightest (neutral) member of Z stable and has interesting implications for phenomenology. We determine the constraints on these models from precision electroweak measurements and Higgs boson decays to two photons. We compute the thermal relic density of the stable member of Z and show that, for masses below 1 TeV, it can make up at most 1% of the dark matter in the universe. We also show that current dark matter direct detection experiments do not constrain the models, but future ton-scale experiments will probe their parameter space.

  18. The accidental data scientist big data applications and opportunities for librarians and information professionals

    Affelt, Amy

    2015-01-01

    Harvard Business Review recently named the data scientist described as a high-ranking professional with the training and curiosity to make discoveries in the world of Big Data as "the sexiest job of the 21st century." Librarians and information professionals have always worked with data in order to meet the information needs of their constituents, thus "Big Data" is not a new concept for them though it is spawning new approaches along with a language all its own. InThe Accidental Data Scientist, Amy Affelt shows information professionals how to leverage their skills and training to master emerging tools, techniques, and vocabulary; create mission-critical Big Data research deliverables; and discover rewarding new career opportunities by embracing their inner Data Scientist.

  19. Forensic aspects of paediatric fractures. Differentiating accidental trauma from child abuse

    Bilo, Rob A.C. [Netherlands Forensic Institute, The Hague (Netherlands). Department of Pathology and Toxicology; Rijn, Rick R. van [Emma Childrens' s Hospital/Academic, Medical Center Amsterdam (Netherlands). Department of Radiology; Robben, Simon G.F. [Maastricht University Medical Center, Maastricht (Netherlands)

    2010-07-01

    Fractures are a common finding in children and it is estimated that 2.1% of all children will suffer at least one fracture before the age of 16. With young children in particular, the question may arise if this is related to child abuse. The aim of this book is to help physicians involved in child abuse cases to interpret radiological findings in light of the forensic circumstances under which they occurred. The authors present up-to-date literature related to the mechanisms underlying non-accidental cases of trauma. In this book not only the radiological findings in child-abuse are discussed, but more importantly, these findings are analyzed from a forensic perspective. Careful attention is paid to evidence regarding reported trauma mechanisms and their clinical outcome; for example, can a fall from a couch result in a femoral fracture, and if not, where is the supporting evidence? (orig.)

  20. Urban Early Adolescent Narratives on Sexuality: Accidental and Intentional Influences of Family, Peers, and the Media.

    Charmaraman, Linda; McKamey, Corinne

    2011-01-01

    In this paper, we examine the ways that early adolescents talked, interacted, and made references to events in their individual and collective lives during photography-based focus groups about sexuality and relationships. Twenty-three participants (10 boys and 13 girls) were recruited from three urban schools participating in a comprehensive sex education impact evaluation in the Northeast. We analyzed conversational narratives that were elicited in a group process while sharing photos of important people, contexts, and situations, showcasing participants' exploration of sexuality and relationships. Our analysis revealed four main themes: (a) direct and indirect family communication about sexuality, (b) accidental and intentional Internet usage, (c) shared and contested peer knowledge, and (d) school as a direct and indirect learning context. Implications and future directions for practice, research, and policy are explored.

  1. Modelo de identificación y caracterización de tramos de carreteras sin accidentes (tramos blancos. Aplicación a la red de autopistas de peaje españolas

    de la Peña-González, E.

    2015-12-01

    Full Text Available The traditional approach to infrastructural safety follows the consideration of mitigation tools, such as the identification and management of black spots or road sections with high accident concentration, or preventing tools, as road safety audits and inspections. A complement to these tools is presented in this paper, from a new perspective: the consideration of road sections where, under similar conditions and similar risk exposure, there are no accidents (white road sections. A model has been calibrated to the Spanish toll motorways network, identifying the specific geometric parameters and traffic characteristics which have the highest influence in the occurrence of white sections with sufficient length, without accidents during a significant period of time: heavy vehicles traffic volume, with of the road section and speed.El planteamiento tradicional de análisis de la accidentalidad en carretera pasa por la consideración de herramientas paliativas, como son la identificación y gestión de los puntos negros o tramos de concentración de accidentes, o preventivas, como las auditorías o inspecciones de seguridad vial. En este artículo se presenta un complemento a estas herramientas, desde una perspectiva novedosa: la consideración de los tramos donde, bajo unas condiciones similares a las de otros tramos y una similar exposición al riesgo, no se producen accidentes (tramos blancos. Se resume el modelo que se ha calibrado para las autopistas de peaje españolas, identificando los parámetros específicos de la geometría de la vía y del tráfico que más influencia tienen en el hecho de que en algunos tramos de suficiente longitud, no se produzcan accidentes durante un periodo significativo de tiempo: el tráfico de pesados, al ancho de calzada y la velocidad de circulación.

  2. Assessing the efficacy of 2 years of maintenance treatment with venlafaxine extended release 75–225 mg/day in patients with recurrent major depression: a secondary analysis of data from the PREVENT study

    Kornstein, Susan G.; Kocsis, James H.; Ahmed, Saeeduddin; Thase, Michael; Friedman, Edward S.; Dunlop, Boadie W.; Yan, Bing; Pedersen, Ron; Ninan, Philip T.; Li, Thomas; Keller, Martin

    2013-01-01

    The objective of this study was to evaluate the long-term efficacy of venlafaxine extended release (ER) ≤225 mg/ day in patients with recurrent major depressive disorder (MDD). In this double-blind trial, outpatients with recurrent MDD (N=1096) were randomized to 10 weeks of acute-phase treatment with venlafaxine ER (75–300 mg/ day) or fluoxetine (20–60 mg/day) followed by a 6-month continuation phase and two consecutive 12-month maintenance phases. At the start of each maintenance period, venlafaxine ER responders were randomized to double-blind venlafaxine ER or placebo. In this analysis, data from responders to acute and continuation treatment were analyzed during the combined maintenance phases while receiving venlafaxine ER ≤225 mg/day. Failure to maintain response was defined as an increase in maintenance dose to 300 mg/day or recurrence. Differences were calculated using Kaplan–Meier methods and compared using log-rank tests. Continuation-phase responders (n =114) receiving venlafaxine ER ≤225 mg/ day comprised the analysis population (venlafaxine ER: n= 55; placebo: n= 59). The estimated probability for remaining well across 24 months of maintenance treatment was 67% for venlafaxine ER and 41% for placebo (P = 0.007). Venlafaxine ER effectively maintained response at doses ≤225 mg/day for up to 2.5 years in patients with recurrent MDD. The findings are consistent with those of the full data set. PMID:18854724

  3. El Cuerpo Militar de Sanidad en la Investigación de Accidentes Aéreos

    F. Rios Tejada

    2012-12-01

    Full Text Available La investigación de un accidente o incidente aéreo puede ser simple o enormemente compleja. El proceso de investigación puede conducir a la elaboración de un informe directo y conciso o lo más frecuente, significa un largo camino de recopilación, análisis, estudio y finalmente la elaboración de posibles conclusiones. En este proceso, los aspectos médicos, psicológicos, ambientales, psicosociales o ergonómicos englobados en el término genérico de factores humanos cobran una especial relevancia, atribuyéndose hasta un 60-80% de causas directas o coadyuvantes al mismo. En este trabajo se revisan los antecedentes jurídicos y base legal en la que se apoya la Comisión para la investigación técnica de accidentes de aeronaves militares (CITAAM, así como sus atribuciones, organización y composición, sus funciones generales y más concretamente las encomendadas al vocal médico de la misma. Desde su creación en 1994, la experiencia acumulada ha sido enorme, haciéndose mención de algunos datos de interés estadístico pero señalando también la labor de formación realizada y su proyección nacional e internacional, sobre todo en el marco de la OTAN.

  4. Circumstances and factors associated with accidental deaths among children, adolescents and young adults in Cuiaba, Brazil

    Christine Baccarat de Godoy Martins

    Full Text Available CONTEXT AND OBJECTIVE Analysis on accidents from the perspective of population segments shows there is higher incidence among children, adolescents and young adults. Since the characteristics and circunstances of the event are closely related to educational, economic, social and cultural issues, identifying them may contribute towards minimizing the causes, which are often fatal. The aim here was to identify the environmental, chemical, biological and cultural factors associated with deaths due to accidents among children, adolescents and young adults in Cuiabá, in 2009. DESIGN AND SETTING This was a descriptive cross-sectional study conducted in Cuiabá, Mato Grosso, Brazil. RESULTS Thirty-nine accidental deaths of individuals aged 0 to 24 years were examined: 56.4% due to traffic accidents; 25.6%, drowning; 10.3%, aspiration of milk; 5.1%, falls; and 2.6%, accidentally triggering a firearm. Male victims predominated (82.1%. The presence of chemical, environmental and biological risk factors was observed in almost all of the homes. Regarding cultural factors and habits, a large proportion of the families had no idea whether accidents were foreseeable events and others did not believe that the family's habits might favor their occurrence. Delegation of household chores or care of younger siblings to children under the age of 10 was common among the families studied. CONCLUSION The results point towards the need to have safe and healthy behavioral patterns and environments, and to monitor occurrences of accidents, thereby structuring and consolidating the attendance provided for victims.

  5. Observations on increased accidental asphyxia deaths in infancy while cosleeping in the state of Maryland.

    Li, Ling; Zhang, Yang; Zielke, Ron H; Ping, Yan; Fowler, David R

    2009-12-01

    The Office of the Chief Medical Examiner (OCME) has recorded a significant increase of accidental asphyxia deaths in infancy associated with cosleeping in the state of Maryland in 2003. A total of 102 infants died suddenly and unexpectedly during 2003 in the state of Maryland. Of the 102 infants, 46 (45%) were found cosleeping. The frequency of cosleeping among these 102 infants was 28% (29/102) for black infants and 15% (15/102) for white infants. Ten of the 46 cosleeping infant deaths (20%) were determined to be the result of accidental asphyxia, and 28 cosleeping infant deaths (59%) were classified as "undetermined" because the possibility of asphyxia due to overlay while cosleeping could not be ruled out. Only 21 cases were determined to be Sudden Infant Death Syndrome (SIDS), which is consistent with the continuous decline of SIDS death in Maryland since 1994. The age of asphyxiated cosleeping infants ranged from 15 days to 9 months. Nine out of the 10 asphyxia deaths were black infants. The most common sleeping location of the asphyxia infants was on a couch/sofa, followed by an adult bed. Crib availability was documented in all of the cosleeping cases. A majority (61%) of the cosleeping infants (28/46) had an available crib or bassinet at home and 9 out of 10 asphyxiated cosleeping infants had a crib at home at the time of the incident. This report focuses on the detailed scene investigation findings of infant victims who died of asphyxia while cosleeping. The shift of diagnosis in sudden infant death investigation is also addressed.

  6. ACCIDENTAL SUBCUTANEOUS INJECTION OF VECURONIUM BROMIDE IN A PATIENT WITH BURNS

    Usha Dev

    2014-10-01

    Full Text Available BACKGROUND AND OBJECTIVES: In patients with burn injury drug pharmacology will be altered and this poses special anaesthetic challenge when an subcutaneous injection of a non- depolarizing muscle relaxant occurs in such a patient. Small studies remain an important source of knowledge and hence this study aims to provide information on the anaesthetic management in a case of accidental subcutaneous injection of vecuronium bromide in a burns patient. PRESENTATION, DIAGNOSIS & MANAGEMENT: A 22 year young male with 4 days old hot water induced grade 1 burns involving 45% of body surface area was posted for burns dressing. Anaesthesia was induced with propofol and vecuronium bromide through an external jugular vein to aid tracheal intubation. As the patient was not anaesthetized even after 10 minutes routine check lead to the discovery of fullness at the tip of the intravenous catheter indicating an extravasation of the drugs. Hence the other external jugular vein was cannulated and the patient induced and intubated using propofol, sevoflurane, nitrous oxide and oxygen. The action of vecuronium outlasted the duration of surgery. So the patient continued to receive support of mechanical ventilation with nitrous oxide and oxygen. It took 130 minutes for the clinical signs of recovery from the muscle relaxant to manifest. He was then reversed & extubated with subsequent good recovery. CONCLUSION: Subcutaneous injection of these drugs poses problems of delayed onset of action and prolonged duration of action. In an inadvertent accidental subcutaneous 0.1 mg/kg vecuronium bromide injection in a patient with 4 day old 45% burns showed delayed onset action and prolonged neuromuscular blockade due to subcutaneous deposition of the drug which was managed with mechanical ventilation .The reported resistance to the action of NDMR drugs in patient with burns was not noticed here probably because of the age of the thermal injury.

  7. Imaging of accidental contamination with F-18-solution; a quick trouble-shooting procedure

    Kalevi Kairemo

    2016-01-01

    Full Text Available To the best of our knowledge, imaging of accidental exposure to radioactive fluorine-18 (F-18 due to liquid spill has not been described earlier in the scientific literature. The short half-life of F-18 (t½=110 min, current radiation safety requirements, and Good Manufacturing Practice (GMP regulations on radiopharmaceuticals have restrained the occurrence of these incidents. The possibility of investigating this type of incidents by gamma and positron imaging is also quite limited. Additionally, a quick and precise analysis of radiochemical contamination is cumbersome and sometimes challenging if the spills of radioactive materials are low in activity. Herein, we report a case of accidental F-18 contamination in a service person during a routine cyclotron maintenance procedure. During target replacement, liquid F-18 was spilled on the person responsible for the maintenance. The activities of spills were immediately measured using contamination detectors, and the photon spectrum of contaminated clothes was assessed through gamma spectroscopy. Despite protective clothing, some skin areas were contaminated, which were then thoroughly washed. Later on, these areas were imaged, using positron emission tomography (PET, and a gamma camera (including spectroscopy. Two contaminated skin areas were located on the hand (9.7 and 14.7 cm2, respectively, which showed very low activities (19.0 and 22.8 kBq respectively at the time of incident. Based on the photon spectra, F-18 was confirmed as the main present radionuclide. PET imaging demonstrated the shape of these contaminated hot spots. However, the measured activities were very low due to the use of protective clothing. With prompt action and use of proper equipments at the time of incident, minimal radionuclide activities and their locations could be thoroughly analyzed. The cumulative skin doses of the contaminated regions were calculated at 1.52 and 2.00 mSv, respectively. In the follow-up, no skin

  8. Study of the degradations caused by nuclear accidental conditions on a steel coating

    Ayrinhac, F.; Terriol, J.M. [EDF Ceidre TEGG (France)

    2011-07-01

    The coatings used in nuclear power plants have an interest to make surfaces easily decontaminated and to protect carbon steel (liner and steelworks) from the corrosion. However, in the event of accidental conditions, in particular combining radiation and fast increase of temperature and pressure, these paintings must not constitute an uncontrolled source of debris which may block the safety related functions of core cooling. This experimental study reports the influence of thickness and colour of the withstanding of a steel coating during accidental conditions. The steel coating chosen has been qualified for the liner containment of EDF new generation nuclear power plants (EPR). According to its data sheet, it is composed of an anti-corrosion primer (45 {mu}m), of an intermediate coat (same nature than the primer, 45 {mu}m) and a top coat (50 {mu}m). The system, applied using an conventional spray, was studied by optical and electronic microscopy. After gun airless application and drying, steel samples underwent an irradiation test, a LOCA test followed by a post-accident (100 C an d 100% HR during 10 days). Microscopic analysis by SEM and optical microscopy were carried out in order to evaluate and compare degradations of samples. In conclusion, whatever the color chosen or the thickness obtained, the primers and second coat ('internal layer') do not undergo significant evolution during the test. The greatest part of degradations is inflicted on the top coat. These degradations take the form of vacuums of two types, micro-porosity (few microns diameter) and surface blisters connected with internal spherical vacuums of size ranging between 8 and 50 {mu}m

  9. Amputación corporal por accidente de trabajo en auxiliar de enfermería

    Alexander Finol Muñoz

    2014-12-01

    Full Text Available Los auxiliares de enfermería son un rango profesional expuesto a múltiples riesgos por las actividades inherentes a su trabajo, expuestos constantemente a sustancias desinfectantes que sin el uso apropiado de equipos de protección individual, puede provocar efectos adversos y lesiones en el trabajador. Caso Clínico: Mujer de 51 años de edad, auxiliar de enfermería, con antecedentes de Diabetes Mellitus tipo I y Síndrome de Túnel Carpiano. Presenta derrame accidental de líquido mientras llenaba envase de Biguanid®, cayéndole en todo el cuerpo, por lo que decide cambiarse el uniforme entero, conservando calcetines y zapatos por el resto del turno. Posteriormente presenta lesiones en región dorsal de 4tº dedo de pie izquierdo, las cuales reciben tratamiento médico y seguimiento, con evolución tórpida, se evidencia edema y osteomielitis de la falange por lo que se decide amputar el dedo afectado. Una vez recuperada, fue estudiada con pruebas de provocación, evidenciando la susceptibilidad de la trabajadora a dicho desinfectante. Se propone al Instituto Nacional de Seguridad Social (INSS como accidente de trabajo y una indemnización por lesión permanente no invalidante, ambas peticiones con respuesta favorable para la trabajadora. Actualmente sigue desempeñando sus funciones como auxiliar en el hospital. El cumplimiento y vigilancia de las normas de prevención, basados en los riesgos laborales permitirá evitar este tipo de incidentes en la población laboral, evitando a largo plazo lesiones corporales, discapacidades y bajas laborales que alteran la calidad de vida del trabajador y de su entorno profesional.

  10. Estructuración del diplomado en investigación de accidentes aéreos de la Fuerza Aérea Colombiana

    Jean Paul Strong Flores

    2006-01-01

    Full Text Available Esta investigación tiene como objetivo la elaboración del diplomado en investigación de accidentes aéreos que suministrará las competencias necesarias para liderar las investigaciones de accidentes o incidentes aéreos. Esto en el marco de la educación continuada en investigación de accidentes aéreos permitirá a los oficiales de seguridad determinar con exactitud las causas de los accidentes, de tal forma que sea una medida correctiva para desarrollar destreza y habilidades en la investigación de accidentes.

  11. Bullying Prevention for the Public

    2012-01-19

    This is the first podcast of a series to discuss the severity of bullying and provide resources for prevention efforts. CDC shares the most recent statistics and trends, provides valuable tips to implement in communities, and teaches individuals how to take action against bullying.  Created: 1/19/2012 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 1/19/2012.

  12. Perfiles resilientes y calidad de vida en personas con discapacidad sobrevenida por accidentes de tráfico

    Raquel Suriá Martínez

    2015-09-01

    Conclusión: Esto sugiere la necesidad de profundizar en el conocimiento de la resiliencia y en el diseño de programas que incrementen la calidad de vida de las personas con discapacidad tras un accidente de tráfico.

  13. Accidental and deliberate microbiological contamination in the feed and food chains — How biotraceability may improve the response to bioterrorism

    Knutsson, Rickard; van Rotterdam, Bart; Fach, Patrick

    2011-01-01

    A next frontier of the global food safety agenda has to consider a broad spectrum of bio-risks, such as accidental and intentional contaminations in the food and feed chain. In this article, the background for the research needs related to biotraceability and response to bioterrorism incidents ar...

  14. Notificación de accidentes y enfermedades laborales al Ministerio de Trabajo. Perú 2010-2014

    Christian R Mejia

    Full Text Available Con el objetivo de determinar las tendencias de los accidentes y enfermedades laborales notificadas al Ministerio de Trabajo del Perú, se realizó un estudio descriptivo de datos secundarios, con los reportes extraídos de los boletines mensuales desde septiembre de 2010 a diciembre de 2014. Se notificaron a nivel nacional 54 596 accidentes laborales no mortales, las tasas de los accidentes laborales no mortales por millón de habitantes aumentaron en el período 2011- 2013 (296,5 el 2011, 955,9 el 2012 y 1176,3 el 2013, disminuyendo en el 2014 (878,9. Hubieron 674 accidentes mortales, cuyas tasas se incrementaron entre el 2011-2012 y se redujeron entre el 2013-2014. Se reportaron 346 enfermedades laborales, las más frecuentes fueron los casos de hipoacusia (77, enfermedades por posturas inadecuadas (57 y dermatitis alérgica (44; los reportes se redujeron de 6,9 en el 2011 a 2,3 en el 2014. Los reportes de enfermedades laborales fueron disminuyendo, lo que podría indicar una subnotificación importante

  15. ELECTROMAGNETIC RELEASE MECHANISM

    Michelson, C.

    1960-09-13

    An electromagnetic release mechanism is offered that may be used, for example, for supporting a safety rod for a nuclear reactor. The release mechanism is designed to have a large excess holding force and a rapid, uniform, and dependable release. The fast release is accomplished by providing the electromagnet with slotttd polts separated by an insulating potting resin, and by constructing the poles with a ferro-nickel alloy. The combination of these two features materially reduces the eddy current power density whenever the magnetic field changes during a release operation. In addition to these features, the design of the armature is such as to provide ready entrance of fluid into any void that might tend to form during release of the armature. This also improves the release time for the mechanism. The large holding force for the mechanism is accomplished by providing a small, selected, uniform air gap between the inner pole piece and the armature.

  16. Ten Tips to Prevent Infections During Pregnancy

    2007-12-14

    This podcast gives 10 tips for preventing infections during pregnancy.  Created: 12/14/2007 by National Center for Birth Defects and Developmental Disabilities (NCBDDD).   Date Released: 1/10/2008.

  17. Poison Prevention

    ... Prevention Listen Español Text Size Email Print Share Poison Prevention Page Content Article Body Post the Poison Help number 1-800-222-1222 on the ... or empty container of a toxic substance, call Poison Help immediately. More than a million American children ...

  18. Preventive Medicine.

    Jozwiak, Dick

    1998-01-01

    Argues the importance of regularly inspecting thermoplastic roofs to avoid costly repairs. Preventive measures such as access restriction and the use of protective mats and pads to prevent third-party accidents are discussed as is the importance of checking for drain blockages. (GR)

  19. 品管圈活动在降低老年住院患者跌倒风险的管理%Quality control circle for reducing risk of accidental falls of elderly inpatients

    雷红菊; 朱娉怡; 甄洁洁

    2014-01-01

    目的 探索品管圈活动对降低老年住院患者跌倒风险的影响.方法 成立品管圈小组,开展如何减少老年住院患者跌倒风险的活动主题,分析老年住院患者跌倒的风险并采取加强教育培训、加强制度的落实,圈长,圈员定期检查控制、多部门沟通协调的措施,实施质量持续改进.结果 实施品管圈活动后老年住院患着的跌倒发生率从0.14%明显下降到0.05%(x 2=13.26和12.02,P<0.005).结论 开展品管圈活动,能提高患者安全性,减少老年住院患者跌倒发生率,增强了护理人员的安全管理意识.%Objective To investigate the effect of quality control circle(QCC) for reducing the risk of accidental falls of elderly inpatients.Methods A relational seminar was organized and a specific QCC group was set up to analyze the risk factors of accidental falls of elderly inpatients.Some specific activites including enhanced training,implementation of regulations,regular inspection,multi-sectoral communication and coordination were carried out.Results After the implementation of QCC,the ratio of accidental falls of elderly inpatients decreased from 0.14% to 0.05%,with statistical differences (P < 0.005).Conclusions Implementing QCC can make the patients safer,prevent them from accidental falls,and effectively enhance the security management awareness of nurses.

  20. Electromyography of arrow release in archery.

    Hennessy, M P; Parker, A W

    1990-01-01

    An electronic arrow movement detector was used to accurately locate the muscle activity associated with release of the arrow during shooting in archery. Digital computer analysis of the electromyograms from thirty shots for two archers facilitated an examination of the relationship between the measured activity of the muscles and their function during release. Changes present in the direct and integrated electromyograms of muscles acting at the wrist and elbow joints of the bow arm and the shoulder of the draw arm tended to anticipate the moment of arrow release. These changes would produce muscular force to reduce unwanted movement at this critical phase of the shot in the bow arm and initiate release of the bow string by the fingers. This study provides a detailed quantitative analysis of the muscular action of the technique and identifies possibilities for prevention of injury by improving the understanding of muscle action in shooting.

  1. Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

    Impagnatiello Francesco

    2010-11-01

    Full Text Available Abstract Background Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs mitigate DAergic neurotoxicity in rodent models of PD. Consistent with these findings, epidemiological analysis indicated that certain NSAIDs may prevent or delay the progression of PD. However, a serious impediment of chronic NSAID therapy, particularly in the elderly, is gastric, renal and cardiac toxicity. Nitric oxide (NO-donating NSAIDs, have a safer profile while maintaining anti-inflammatory activity of parent compounds. We have investigated the oral activity of the NO-donating derivative of flurbiprofen, [2-fluoro-α-methyl (1,1'-biphenyl-4-acetic-4-(nitrooxybutyl ester], HCT1026 (30 mg kg-1 daily in rodent chow in mice exposed to the parkinsonian neurotoxin MPTP. Methods Ageing mice were fed with a control, flurbiprofen, or HCT1026 diet starting ten days before MPTP administration and continuing for all the experimental period. Striatal high affinity synaptosomial dopamine up-take, motor coordination assessed with the rotarod, tyrosine hydroxylase (TH- and dopamine transporter (DAT fiber staining, stereological cell counts, immunoblotting and gene expression analyses were used to assess MPTP-induced nigrostriatal DAergic toxicity and glial activation 1-40 days post-MPTP. Results HCT1026 was well tolerated and did not cause any measurable toxic effect, whereas flurbiprofen fed mice showed severe gastrointestinal side-effects. HCT1026 efficiently counteracted motor impairment and reversed MPTP-induced decreased synaptosomal [3H]dopamine uptake, TH- and DAT-stained fibers in striatum and TH+ neuron loss in subtantia nigra pars compacta (SNpc, as opposed to age-matched mice fed with a control diet. These effects were associated to a significant decrease in reactive

  2. Tampão peridural com dextran 40 na profilaxia da cefaléia pós-punção acidental da duramáter em paciente HIV positivo: relato de caso Tampón peridural con dextran 40 en la profilaxia de la cefalea pós-punción accidental de la duramáter en paciente SIDA positivo: relato de caso Epidural patch with dextran 40 to prevent postdural puncture headache in an HIV patient: case report

    Marcos Guilherme Cunha Cruvinel

    2002-11-01

    han sido relatadas. El objetivo de este articulo es presentar un caso del uso del tampón peridural con dextran 40 en la profilaxia de la cefalea pós-punción de duramáter en paciente portador del virus de la imunodeficiencia humana (HIV, con historia de cefalea en anestesia subaracnóidea anterior. Relato do caso: Paciente masculino, 31 años, 70 kg, estado físico ASA II, portador de SIDA, para tratamiento de condilomatosis anal recidivada, con relato de cefalea intensa y limitante durante dos semanas después de anestesia subaracnóidea (aguja Quincke 25G. Durante la tentativa de anestesia peridural con aguja de Tuohy 18G en L3-L4, hubo perforación accidental de la duramáter. Fueron inyectados, por dos veces, 20 ml de dextran 40 a 10% por catéter peridural; la primera, 150 minutos después de la administración de los anestésicos y la segunda en la mañana siguiente a la cirugía. El paciente evoluyó asintomático y recibió alta al día siguiente a su internación. CONCLUSIONES: El uso del tampón con soluciones coloides como el dextran 40 no está bien establecido, sin embargo existen algunos relatos de su uso con suceso y entendemos que su potencial debe ser mejor explorado.BACKGROUND AND OBJECTIVES: Postdural puncture headache is a well-known complication of spinal and epidural anesthesia and, so far, its most effective treatment is the epidural blood patch. Nevertheless this is an invasive procedure subject to severe complications. Its use in special patient populations (HIV positive patients and leukemias is controversial. Several alternatives have been reported. This study aimed at showing a case of prophylactic epidural dextran 40 patch in an HIV patient with previous history of headache following spinal anesthesia. CASE REPORT: Male patient, 31 years old, 70 kg, physical status ASA II, HIV positive, presented for recurrent anal condylomatosis treatment, with a history of severe and limiting headache for two weeks following spinal anesthesia. (25G

  3. Release the Body, Release the Mind.

    Stoner, Martha Goff

    1998-01-01

    A college English teacher describes the anxiety and resentment of students during in-class writing assignments and the successful classroom use of meditation and body movement. Movement seemed to relax the students, change their attitudes, and release their creative impulses to write. Implications related to the body-mind connection are pondered.…

  4. Barrier and operational risk analysis of hydrocarbon releases (BORA-Release). Part I. Method description.

    Aven, Terje; Sklet, Snorre; Vinnem, Jan Erik

    2006-09-21

    Investigations of major accidents show that technical, human, operational, as well as organisational factors influence the accident sequences. In spite of these facts, quantitative risk analyses of offshore oil and gas production platforms have focused on technical safety systems. This paper presents a method (called BORA-Release) for qualitative and quantitative risk analysis of the platform specific hydrocarbon release frequency. By using BORA-Release it is possible to analyse the effect of safety barriers introduced to prevent hydrocarbon releases, and how platform specific conditions of technical, human, operational, and organisational risk influencing factors influence the barrier performance. BORA-Release comprises the following main steps: (1) development of a basic risk model including release scenarios, (2) modelling the performance of safety barriers, (3) assignment of industry average probabilities/frequencies and risk quantification based on these probabilities/frequencies, (4) development of risk influence diagrams, (5) scoring of risk influencing factors, (6) weighting of risk influencing factors, (7) adjustment of industry average probabilities/frequencies, and (8) recalculation of the risk in order to determine the platform specific risk related to hydrocarbon release. The various steps in BORA-Release are presented and discussed. Part II of the paper presents results from a case study where BORA-Release is applied.

  5. [Acute accidental poisoning in children: aspects of their epidemiology, aetiology, and outcome at the Charles de Gaulle Paediatric Hospital in Ouagadougou (Burkina Faso)].

    Kouéta, Fla; Dao, Lassina; Yé, Diarra; Fayama, Zéinabou; Sawadogo, Alphonse

    2009-01-01

    Accidents are a daily concern in the paediatric ward because of their frequency, diversity and severity. Acute accidental poisoning (AAP) accounts for an important portion of these. To help improvement management of AAP, we conducted a retrospective study covering a period of 2 years from January 2005 to December 2006 at Charles de Gaulle Paediatric University Hospital in Ouagadougou. Of 9390 admissions during the study period, 123 children, or 1.3%, were admitted for poisoning. A cumulative average of 11 were admitted monthly, with a peak of 16 patients in April 2005 and 2006, together. AAP was most common among children aged 1 to 4 years. Their mean age was 3 years and ranged from 6 days to 12 years. Boys outnumbered girls, with a sex ratio of 1.2. Mothers of more than half (61%) of the children poisoned worked in the home. Household products accounted for 44.7% of AAPs, followed by drug (22.7%) and food (22%) poisoning. Kerosene and other petroleum products topped the list of household products, with 54.5%. Tranquilizers (46.4%) and dairy products (37%) dominated the drug and food poisoning categories. Immediate outcome was fatal in 3% of cases, and three quarters of these deaths occurred during drug poisoning of children aged 1 to 4 years. The mean hospital stay was 2 days, and ranged from 0 to 9 days. Health officials, the media, and community outreach must all help to increase awareness about the dangers of poisoning and of preventive measures.

  6. Research of CIEMAT in; Investigacion del CIEMAT en secuencias SGTR de accidente severo

    Herranz, L. E.; Lopez del Pra, C.; Sanchez Velasco, F. J.

    2006-07-01

    Severe accident sequences with Steam Generator Tube Ruptures (STGR) are risk dominant PWR reactors, in spite of being very low probability events. Their relevance lies in the potential radioactive release from reactor coolant system to the environment (containment bypass). Lack of knowledge on the steam generator capability to mitigate Source Term has prevented its consideration in probabilistic safety studies and severe accident management guidelines. CIEMAT has undertaken a theoretical and experimental research program that is providing results on the aerosol retention in the nearby of the tube breach under the most credible challenging conditions: total absence of water in the secondary side of the steam generator. This paper describes the objectives, the approach and the obtained (Phase I) and foreseeable (Phase II) results of this program. Its development has been internationally framed within the EU-SGTR and the ARTIST program. The experimental activities of Phase I, carried out in the PECA-SGTR facility, showed a low particle deposition (less than 20%) on tube surfaces around the breach. Data highlighted that the gas mass flux effect was substantially more influencing than other, like the ones of breach shape and orientation. Above 100 kg/h, the higher the gas mass flux the lower the retention reduction. In addition, the tests pointed out the potential role that phenomena like particle fragmentation and/or resuspension could play in the scenario. The Phase II of the program will be aimed at confirming and quantifying the Phase I observations and at analyzing the effect of particle nature. On the theoretical side, a model based on the filter concept is being developed (ARISG). It considers inertial impaction and turbulent deposition as the main aerosol retention mechanisms. Both require a detailed aerodynamic characterization of the gas flow in the scenario, so that 3D fluid-dynamic simulations are being conducted and validated against ad-hoc experiments of

  7. Attention Deficit Hyperactivity Disorder Symptoms, Sleepiness and Accidental Risk in 36140 Regularly Registered Highway Drivers

    Philip, Pierre; Micoulaud-Franchi, Jean-Arthur; Lagarde, Emmanuel; Taillard, Jacques; Canel, Annick; Sagaspe, Patricia; Bioulac, Stéphanie

    2015-01-01

    Background Attention Deficit Hyperactivity Disorder (ADHD) is a frequent neurodevelopmental disorder that increases accidental risk. Recent studies show that some patients with ADHD can also suffer from excessive daytime sleepiness but there are no data assessing the role of sleepiness in road safety in patients with ADHD. We conducted an epidemiological study to explore sleep complaints, inattention and driving risks among automobile drivers. Methods and Findings From August to September 2014, 491186 regular highway users were invited to participate in an Internet survey on driving habits. 36140 drivers answered a questionnaire exploring driving risks, sleep complaints, sleepiness at the wheel, ADHD symptoms (Adult ADHD Self-Report Scale) and distraction at the wheel. 1.7% of all drivers reported inattention-related driving accidents and 0.3% sleep-related driving accidents in the previous year. 1543 drivers (4.3%) reported ADHD symptoms and were more likely to report accidents than drivers without ADHD symptoms (adjusted OR = 1.24, [1.03–1.51], p 15) versus 3.2% of drivers without ADHD symptoms and 20.5% reported severe sleepiness at the wheel versus 7.3%. Drivers with ADHD symptoms reported significantly more sleep-related (adjusted OR = 1.4, [1.21–1.60], p < .0001) and inattention-related (adjusted OR = 1.9, [1.71–2.14], p<0001) near misses than drivers without ADHD symptoms. The fraction of near-misses attributable to severe sleepiness at the wheel was 4.24% for drivers without ADHD symptoms versus 10,35% for drivers with ADHD symptoms. Conclusion Our study shows that drivers with ADHD symptoms have more accidents and a higher level of sleepiness at the wheel than drivers without ADHD symptoms. Drivers with ADHD symptoms report more sleep-related and inattention-related near misses, thus confirming the clinical importance of exploring both attentional deficits and sleepiness at the wheel in these drivers. Road safety campaigns should be improved to

  8. Transferencia del aprendizaje motor en pacientes con antecedentes de accidente cerebrovascular: serie de casos

    Karen Castro-Medina

    2015-04-01

    Full Text Available Antecedentes. La rehabilitación es un proceso de reaprendizaje motor, que mejora el desempeño en términos de adquisición de nuevas habilidades y adaptación o refinamiento de habilidades aprendidas previamente. A pesar de este conocimiento, existen, considerablemente, pocos estudios que describan el aprendizaje motor después de un accidente cerebrovascular (ACV y la relevancia del mismo en los procesos de rehabilitación y recuperación. Objetivo. Describir la transferencia del aprendizaje motor en pacientes con antecedentes de accidente cerebrovascular después de un tratamiento con procedimientos de reeducación funcional. Materiales y métodos. Se realizó un estudio descriptivo de dos casos con pacientes que recibieron tratamiento fisioterapéutico ambulatorio con los principios de reeducación funcional desarrollados en el Hospital de las Clínicas de la Universidad de São Paulo (Brasil, entre los meses de agosto y octubre de 2013. La transferencia del aprendizaje motor se determinó según los resultados obtenidos en la evaluación de balance funcional (Mini-BESTest. Se evaluó el test antes y después del tratamiento y se compararon los resultados para determinar el porcentaje de mejora. Resultados. En los dos casos se observó mejora clínica en el desempeño de la evaluación de balance funcional Mini-BESTest con un porcentaje de mejora entre el 21% y el 41%. Conclusión. Existen pocos hallazgos literarios que describen el mantenimiento de la capacidad de aprendizaje motor en pacientes con antecedentes de ACV. Este estudio reportó la capacidad para transferir el aprendizaje motor a una habilidad motora no aprendida (balance en dos casos, con base en la mejoría clínica del desempeño motor en el test aplicado.

  9. 78 FR 8456 - Coverage of Certain Preventive Services Under the Affordable Care Act

    2013-02-06

    ...; states; secular organizations; private citizens; and women's rights and reproductive health advocacy..., 2011, HRSA adopted and released guidelines for women's preventive services based on ] recommendations... evidence on women's preventive services (Women's Preventive Services: Required Health Plan...

  10. Enfermedad preexistente, agravamiento y/o accidente de trabajo: análisis de 10 casos clínicos

    Ana M.ª González Onetti

    2014-01-01

    Full Text Available En nuestro centro asistencial se han atendido en el año 2012, 1.304 primeras asistencias, de las cuales 85 fueron consideradas no accidente de trabajo/enfermedad profesional. Hemos elegido al azar 10 casos clínicos donde existió discrepancia por parte del paciente cuando los servicios médicos determinaron que la patología que sufría el paciente no era accidente de trabajo y/o agravamiento por lo que se derivó a su médico de atención primaria quien emitió parte de baja por contingencias comunes y se inició determinación de contingencias ante el INSS por parte del Servicio Andaluz de Salud. En 7 de los casos existió discrepancia entre los inspectores médicos del INSS y los servicios médicos de la mutua, en 3 de ellos se consideraron enfermedad común al existir enfermedad preexistente. De los casos analizados comprobamos que no existían criterios unificados, claros y precisos entre enfermedad preexistente, agravamiento y/o accidente de trabajo dependiendo del médico evaluador y/o médico de la mutua determinar si era o no accidente de trabajo. Si no existían antecedentes médicos por el SAS y/o bajas previas por ITCC por la misma patología o similar el INSS determino siempre la contingencia como accidente de trabajo. El tiempo medio de los 10 casos analizados entre el inicio de la determinación de contingencias y la comunicación de la resolución por parte del INSS fue de 240 días. De los 7 casos que fueron accidente de trabajo, 6 seguían en situación de baja laboral y un caso se encontraba curado e incorporado a su puesto de trabajo.

  11. A Multi-Entity Field Approximation to determine the source location of multiple atmospheric contaminant releases

    Annunzio, Andrew J.; Young, George S.; Haupt, Sue Ellen

    2012-12-01

    In the event of an accidental or intentional contaminant release, it is imperative to locate the source of the contaminant for use in hazard prediction models. In some situations more than a single contaminant release will be present, which becomes a complicating factor when contaminants from these releases significantly overlap. Here we present a Lagrangian approach to determine the source locations of multiple contaminant releases. For this approach, we assume that the concentration field is approximated by a superposition of contaminant entities, where an entity is a discrete object; namely a puff for an instantaneous release and a plume for a continuous release. The state of each entity is inferred from surface observations of the contaminant, and extrapolation of each entity's state provides an estimate of the contaminant source locations. We call this method a Multi-Entity Field Approximation (MEFA) because together the entities' concentration fields sum to approximate the observed concentration field. In this work, we outline the MEFA process for both instantaneous and continuous contaminant releases using data from two FUSION Field Trial 2007 (FFT07) Trials where contaminant fields from multiple contaminant releases overlap close to the source location.

  12. La orejuela izquierda como fuente de accidentes cerebrovasculares: cerrar (y cómo, o no cerrar (y por qué Left atrial appendage as a source of stroke: to close (and how, or not to close (and why

    R. Hernández-Estefanía

    2012-04-01

    Full Text Available La orejuela izquierda se considera la principal fuente de émbolos en los accidentes cerebrovasculares que se producen en pacientes con fibrilación auricular. El tratamiento con anticoagulantes orales reduce significativamente el riesgo de accidentes embólicos cerebrales en relación con la aspirina, pero se asocia a riesgo de complicaciones hemorrágicas, por lo que no siempre son utilizados. Se ha descrito que el cierre de la orejuela izquierda reduce la tasa de accidentes tromboembólicos y en la actualidad se recomienda en pacientes en fibrilación auricular sometidos a cirugía mitral, pero la formación de émbolos en estos pacientes puede deberse a otras causas, y la implicación de la orejuela podría ser menor de la que se presupone. Además, no todos los pacientes son candidatos para la anticoagulación oral, y no todos se mantienen en un rango terapéutico adecuado, lo que podría justificar la formación de trombos auriculares. Existen diversos métodos para el cierre de la orejuela: sutura directa, exclusión epicárdica mediante grapadora o clip, u oclusión mediante los recientes dispositivos endovasculares de aplicación percutánea. Pero, según la bibliografía, la efectividad de estos métodos para ocluir completamente la orejuela, así como su seguridad y eficacia para la prevención de accidentes embólicos cerebrales, pueden presentar resultados dispares. Para aumentar la controversia, algunos métodos de cierre con sutura no revelan un claro beneficio e, incluso, en algunos se describe un aumento del riesgo de tromboembolismo. Se presenta una revisión sobre la necesidad de cierre de la orejuela izquierda para la prevención de accidentes vasculares cerebrales, así como los diversos procedimientos descritos.Left atrial appendage is considered the main source of emboli in stroke for patients with atrial fibrillation. Oral anticoagulant therapy significantly reduces the risk of cerebral embolic events as compared with

  13. SIRANERISK: Modelling dispersion of steady and unsteady pollutant releases in the urban canopy

    Soulhac, L.; Lamaison, G.; Cierco, F.-X.; Ben Salem, N.; Salizzoni, P.; Mejean, P.; Armand, P.; Patryl, L.

    2016-09-01

    SIRANERISK is an operational model for the simulation of the dispersion of unsteady atmospheric releases of pollutant within and above an urban area. SIRANERISK is built on the same principles as the SIRANE model, and couples a street network model for the pollutant transfers within the urban canopy with a Gaussian puff model for the transfers above it. The performance of the model are here analysed by a detailed comparisons with wind-tunnel experiments. These experiments concern the dispersion of steady and unsteady pollutant releases within and above obstacle arrays with varying geometrical configurations, representing different topologies of idealised urban districts. The overall good agreement between numerical and experimental data demonstrates the reliability of SIRANERISK as an operational tool for the assessment of risk analysis and for the management of crises due to the accidental release of harmful airborne pollutants within a built environment.

  14. Características de los lesionados por accidente de tráfico con alcoholemia positiva Characteristics of road accident victims with positive blood alcohol levels

    Xavier Martínez

    2004-10-01

    Full Text Available Objetivo: Identificar de las características diferenciales de positividad a alcohol en lesionados en accidentes de tráfico atendidos en un servicio de urgencias hospitalario. Métodos: Estudio transversal con sujetos de 18 años o mayores, lesionados en accidentes de tráfico, atendidos en el servicio de urgencias del Área de Traumatología del Hospital Vall d'Hebron, entre julio de 2001 y febrero de 2002. Resultados: La muestra incluyó a 431 pacientes. El 13,7% resultó positivo a la determinación de alcohol: se hallaron diferencias en los varones (odds ratio [OR] = 2,5; IC del 95%, 1,3-5,4 y los lesionados ingresados (OR = 2,7; IC del 95%, 1,3-5,4 y en los que fueron asistidos en fin de semana o festivo (OR = 3,7; IC del 95%, 2,0-6,9, de noche y madrugada (OR = 4,6; IC del 95%, 2,0-10,3 o durante la mañana (OR = 3,6; IC del 95%, 1,5-8,4. Conclusiones: Se ha determinado la existencia de subgrupos de lesionados en accidentes de tráfico con una mayor probabilidad de alcoholemia positiva, en los cuales deberían aplicarse programas de cribado y prevención secundaria más activos desde los servicios de urgencias y de traumatología.Objective: To identify the differential features of positive blood alcohol level (BAL in people injured in road crashes who were attended an acute care service. Methods: Cross-sectional study of persons aged 18 years old or older injured in motor vehicle crashes who were attended in the Traumatology Emergency Department of Vall d'Hebron Hospital (Spain between July 2001 and February 2002. Results: The study sample included 431 patients. A positive alcohol test was found in 13.7% of the sample. A statistically significant and independent association was found between positive BAL and male sex (odds ratio [OR] = 2.5 [95% CI, 1.3-5.4], hospital admission (OR = 2.7 [95% CI, 1.3-5.4], being attended on a weekend (OR = 3.7 [95% CI, 2.0-6.9] and being attended during the night and early morning (OR = 4.6 [95% CI, 2

  15. Accidental oropharyngeal impalement injury in children: A report of two cases

    Hayaki Uchino

    2015-01-01

    Full Text Available Impalement injuries in children may be deeper and more complicated than anticipated. We experienced two cases of accidental impalement injuries, one was through the oral cavity and the other was to the neck. We review these cases and the management of these types of injuries. Case series. In case 1, a 20-month-old girl fell from the table with a toothbrush in her mouth. She was conscious, without any apparent neurologic or vascular injuries. Examination revealed a 2 mm laceration with a small hematoma in the right posterior pharyngeal wall. Contrast-enhanced computed tomography (CECT revealed an air tract penetrating between the mandibular ramus and cervical vertebrae, passing by the carotid sheath, and reaching under the skin of the right posterior neck. Surgical emphysema was extended from the pharynx to the mediastinum. In case 2, a 3-year-old girl fell while holding a pencil. Physical examination revealed a 5 mm laceration in front of her right ear lobe accompanied by a small hematoma. Her facial movement was asymmetric, and she could not close her right eye. CECT showed swelling of the right parotid gland with heterogeneous enhancement and free air just in front of the right carotid sheath, which suggested the object penetrated through the parotid gland. A diagnosis of peripheral facial nerve injury was made. Physicians need to be aware of the potentially life-threatening complications of impalement injuries in children, as well as the specific complications related to proximity to specific anatomic structures.

  16. Neuroimaging for non-accidental head injury in childhood: A proposed protocol

    Jaspan, T.; Griffiths, P.D.; McConachie, N.S.; Punt, J.A.G

    2003-01-01

    Non-accidental head injury (NAHI) is a major cause of neurological disability and death during infancy. Radiological imaging plays a crucial role in evaluating craniospinal injury, both for guiding medical management and the forensic aspects of abusive trauma. The damage sustained is varied, complex and may be accompanied by an evolving pattern of brain injury secondary to a cascade of metabolic and physiological derangements. Regrettably, many cases are poorly or incompletely evaluated leading to diagnostic errors and difficulties in executing subsequent child care or criminal proceedings. It is evident, from cases referred to the authors, that imaging protocols for NAHI are lacking (or only loosely adhered to, if present) in many centres throughout the U.K. Future research in this field will also be hampered if there is a lack of consistent and reliable radiological data. There is no nationally agreed protocol for imaging NAHI. We propose such a protocol, based upon a wide experience in the medical management of child abuse and extensive involvement in the medicolegal aspects of NAHI. Jaspan, T., et al. (2003). Clinical Radiology58, 44--53.

  17. Accidental bilateral Q-switched neodymium laser exposure: treatment and recovery of visual function

    Zwick, Harry; Stuck, Bruce E.; Dunlap, Weldon; Scales, David K.; Lund, David J.; Ness, James W.

    1998-05-01

    A 21 year old female was accidentally exposed in both eyes when she looked into the 10 cm exit aperture of a military laser designator emitting 1064 nm q-switched (30 ns) pulses at a 10 pulse per second rate. Steroid therapy (methylprednisolone sodium succinate) was initiated within 6 hours post exposure. Initial ophthalmoscopic observation revealed small contained macular hemorrhages in each eye. Fluorescein angiography (FA) showed minimal leakage. Visual acuity was 20/100 and 20/60 in OD and OS respectively. Contrast sensitivity in both eyes was depressed across all spatial frequencies by more than 1.5 log units. At four weeks post exposure, no significant macular scarring was apparent and visual acuity returned to 20/25 in both eyes. Contrast sensitivity had improved to normal levels with a peak at 3 cycles/degree. At one year post exposure, visual acuity was 20/13 in both eyes and measures of contrast sensitivity were within normal limits. During the course of recovery, the patient's fixation shifted from a slightly superior temporal site back to the central foveal region. The foveal lesion sites were still evident by ophthalmoscopy and Amsler grid measurements but were deemed functional when the patient placed small targets generated by the scanning laser ophthalmoscope in the lesion site for discrimination. This outcome indicates remarkable recovery of visual function and suggests that early administration of steroids may assist in preserving the natural neural recovery process of the photoreceptor matrix by minimizing intraretinal scar formation.

  18. Failure Criteria for Evaluating Accidental Drops of Fuel Containers at INTEC

    Miller, G. K.

    1998-10-01

    This report presents a failure criterion that has been developed for use in evaluating fuel containers at the Idaho Nuclear Technology and Engineering Center (INTEC) for accidental drop events. The criterion would typically be used in dynamic finite element analyses using the ABA-QUS/Explicit program. The failure criterion used in the past is generally considered to substantially underestimate the strength and ductility of the materials involved. The new criterion is intended to be more realistic, allowing for more accurate impact analyses. The criterion is based on the distortion energy theory, which is considered to be appropriate for the ductile materials typically used in fuel containers. Also addressed in development of the criterion were the effects of strain rate and hydrostatic stress. The importance of these factors, however, is highly dependent on the material used. Three materials specifically addressed in this study were stainless steel, aluminum, and lead. The criterion is presented in the form of guidelines and recommendations that are based on material data obtained from the literature. The most significant difference between these and the previous criterion is that ductile materials are allowed to strain to much higher levels before they are considered to fail.

  19. Biomechanical studies in an ovine model of non-accidental head injury.

    Anderson, R W G; Sandoz, B; Dutschke, J K; Finnie, J W; Turner, R J; Blumbergs, P C; Manavis, J; Vink, R

    2014-08-22

    This paper presents the head kinematics of a novel ovine model of non-accidental head injury (NAHI) that consists only of a naturalistic oscillating insult. Nine, 7-to-10-day-old anesthetized and ventilated lambs were subjected to manual shaking. Two six-axis motion sensors tracked the position of the head and torso, and a triaxial accelerometer measured head acceleration. Animals experienced 10 episodes of shaking over 30 min, and then remained under anesthesia for 6h until killed by perfusion fixation of the brain. Each shaking episode lasted for 20s resulting in about 40 cycles per episode. Each cycle typically consisted of three impulsive events that corresponded to specific phases of the head's motion; the most substantial of these were interactions typically with the lamb's own torso, and these generated accelerations of 30-70 g. Impulsive loading was not considered severe. Other kinematic parameters recorded included estimates of head power transfer, head-torso flexion, and rate of flexion. Several styles of shaking were also identified across episodes and subjects. Axonal injury, neuronal reaction and albumin extravasation were widely distributed in the hemispheric white matter, brainstem and at the craniocervical junction and to a much greater magnitude in lower body weight lambs that died. This is the first biomechanical description of a large animal model of NAHI in which repetitive naturalistic insults were applied, and that reproduced a spectrum of injury associated with NAHI.

  20. The review of autopsy cases of accidental childhood deaths in Istanbul.

    Yayci, Nesime; Pakis, Isil; Karapirli, Mustafa; Celik, Sefa; Uysal, Cem; Polat, Oguz

    2011-08-01

    Children are at increased risk for various causes of injury from accidents. Accidents are, by far, the leading cause of death among children and adolescents. The aim of this study is to evaluate the lethal childhood accidents in İstanbul by age groups. Reports of autopsies performed between 2001 and 2005 in the Morgue Department of the Council of Forensic. Medicine in Istanbul (n :16853) are examined retrospectively. 833 deaths from accidents in children aged 0-18 years are investigated into the study. The parameters of age, gender, types of accidents and causes of death are evaluated. The accidents account for 47.3% of the deaths among children aged 0-18 years. Of 833 cases, 601 (73%) are male and 232 (27%) are female. The female to male ratio is 1/2.6. The highest rate of death from accidents is at the group of 15-18 years. The primary causes of accidental childhood deaths are motor vehicle accidents (23.1%), followed by drowning (20,1%), poisoning (15.7%), and fall from height (15.5%). The incidence and types of trauma vary with socio-economic status and culture. İstanbul, where this study is conducted in, has approximately 3000 autopsy number annually. Therefore, it provides an important database.

  1. Multidetector Computed Tomography Imaging of Facial Trauma in Accidental Falls from Heights

    Salonen, E.M.; Koivikko, M.P.; Koskinen, S.K. [Helsinki Medical Imaging Center, Dept. of Radiology, Toeoeloe Trauma Center, Helsinki Univ. Hospital, Helsinki (Finland)

    2007-04-15

    Purpose: To assess multidetector computed tomography (MDCT) findings in facial trauma in adults who accidentally fall from heights. Material and Methods: Of the MDCT scans of 2413 cases requested by emergency-room physicians for suspected facial injury, 155 (age 15.3-76.7, mean 42.0 years; 134 male, 21 female) met the criteria of falling from heights. These were reviewed by two researchers by consensus. Results: Of these 155, 118 (104 male, 14 female) had 247 fractures, while 37 had no fracture. The fractures were classified into 13 categories, the zygomatic complex being the region most frequently involved. Mean falling height, known in 132 of 155 cases, was 5.7 m (range 0.4-25) in all, 6.0 m (0.4-25) in those suffering a fracture, and 5.0 m (range 0.4-13) in those without a fracture. Patients with Le Fort II, Le Fort III, or frontal bone fractures had fallen higher and frequently had associated skull base fractures, but with considerable overlap in falling heights. Zygomatic arch and nasal bone fractures rarely occurred solitarily. Conclusion: In a fall-from-height injury, nasal bone and zygomatic arch fractures indicate the presence of more severe fractures. Height cannot solely predict injury probability. Clear sinus sign is a valuable aid in assessing midface trauma in falls from heights. Keywords: CT; face; trauma.

  2. Ileum perforation due to accidental chicken bone ingestion a rare cause of the acute abdomen

    Doklestić Krstina S.

    2012-03-01

    Full Text Available Ingestion of foreign bodies is not an uncommon occurrence, but most of them will pass through the gastrointestinal tract without consequences. Complication such as perforation is rare. We present a case of small bowel perforation secondary to the accidental ingestion of a chicken bone. The patient presented with abdominal pain, constipation and vomiting. Clinical examination confirmed generalized abdominal tenderness and rebound tenderness. Abdominal radiography showed multiple dilated loops of small bowel, and abdominal ultrasound (US showed inflammatory changes on small bowel loops, with free fluid and fluid collection around intestinal loops. The patient underwent an emergency laparotomy. Intra operative findings revealed diffuse fibro purulent peritonitis with abscess between central small bowels loops. At about 60 cm from Bauchini valve we found a perforation of ileum at the anti-mesenteric site caused by a sharp chicken wishbone. The patient was treated with resection of the ileum segment (10 cm and primary end-to-end anastomosis. Even that intestinal perforation by a foreign body is rare, physicians should consider possibility of intestinal perforation by a foreign body in the differential diagnosis of acute abdomen in patients presenting with abdominal pain.

  3. Quantification of nerve agent VX-butyrylcholinesterase adduct biomarker from an accidental exposure.

    Solano, Maria I; Thomas, Jerry D; Taylor, James T; McGuire, Jeffrey M; Jakubowski, Edward M; Thomson, Sandra A; Maggio, Vincent L; Holland, Kerry E; Smith, J Richard; Capacio, Benedict; Woolfitt, Adrian R; Ashley, David L; Barr, John R

    2008-01-01

    The lack of data in the open literature on human exposure to the nerve agent O-ethyl-S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) gives a special relevance to the data presented in this study in which we report the quantification of VX-butyrylcholinesterase adduct from a relatively low-level accidental human exposure. The samples were analyzed by gas chromatography-high resolution mass spectrometry using the fluoride ion regeneration method for the quantification of multiple nerve agents including VX. Six human plasma samples from the same individual were collected after the patient had been treated once with oxime immediately after exhibiting signs of exposure. Detection limits of approximately 5.5 pg/mL plasma were achieved for the G-analogue of VX (G-VX). Levels of the G-VX ranged from 81.4 pg/mL on the first day after the exposure to 6.9 pg/mL in the sample taken 27 days after the exposure. Based on the reported concentration of human butyrylcholinesterase in plasma of approximately 80 nM, it can be calculated that inhibition levels of >or= 0.05% of BuChE can be accurately quantified. These data further indicate that the fluoride ion regeneration method is a potentially powerful tool that can be used to assess low-level exposure to VX.

  4. Accidental Interaction between PDZ Domains and Diclofenac Revealed by NMR-Assisted Virtual Screening

    Kengo Kinoshita

    2013-08-01

    Full Text Available In silico approaches have become indispensable for drug discovery as well as drug repositioning and adverse effect prediction. We have developed the eF-seek program to predict protein–ligand interactions based on the surface structure of proteins using a clique search algorithm. We have also developed a special protein structure prediction pipeline and accumulated predicted 3D models in the Structural Atlas of the Human Genome (SAHG database. Using this database, genome-wide prediction of non-peptide ligands for proteins in the human genome was performed, and a subset of predicted interactions including 14 PDZ domains was then confirmed by NMR titration. Surprisingly, diclofenac, a non-steroidal anti-inflammatory drug, was found to be a non-peptide PDZ domain ligand, which bound to 5 of 15 tested PDZ domains. The critical residues for the PDZ–diclofenac interaction were also determined. Pharmacological implications of the accidental PDZ–diclofenac interaction are further discussed.

  5. Maternal and infant characteristics associated with accidental suffocation and strangulation in bed in US infants.

    Carlberg, Michelle M; Shapiro-Mendoza, Carrie K; Goodman, Michael

    2012-11-01

    To identify maternal and infant characteristics associated with accidental suffocation and strangulation in bed (ASSB) in US infants. Using 2000-2002 US linked infant birth and death certificate cohort files, we compared ASSB deaths to survivors. Adjusted odds ratios (aOR) from logistic regression were used to analyze associations between selected maternal and infant characteristics and ASSB mortality. During 2000-2002, 1,064 infants died from ASSB, resulting in an ASSB mortality rate of 9.2 per 100,000 live births. Most ASSB deaths (71%) occurred before an infant reached 4 months old. Maternal factors associated with an increased risk of ASSB were younger age (using maternal age of 25-29 years as reference aOR 2.6 for mothers mortality risk. Younger, less educated, mulitparous, non-Hispanic black or American Indian women and their families who smoke during their pregnancy and deliver male or preterm infants, may need more intense safe sleeping education during the infant's first year of life, especially during the first 4 months of age.

  6. Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation: January 1980-December 1982

    Adams, W.H.; Harper, J.A.; Rittmaster, R.S.; Heotis, P.M.; Scott, W.A.

    1984-01-01

    This report updates, for 1980 through 1982, the results of continuing medical surveillance of a Marshallese population accidentally exposed to radioactive fallout in March 1954. The originally exposed Marshallese population comprised 64 persons on Rongelap Atoll who each received, on the average, an estimated 190 rads of absorbed external gamma radiation, 18 on Ailingnae Atoll who received 110 rads, and 159 on Utirik who received 11 rads. There were, in addition, 3 persons in utero on Rongelap, 1 person in utero on Ailingnae, and 8 persons in utero on Utirik who are considered exposed. The recipients of primary medical care include exposed and comparison populations as well as a rather large number of additional beneficiaries who are seen on a humanitarian basis of practical need and resource availability. In recent years, about 1400 people have been seen annually. This report, however, deals with four clearly defined groups: the remaining individuals who were exposed to radioactive fallout on Rongelap, Ailingnae, and Utirik in 1954 (including those in utero), and a comparison population of individuals from Rongelap who were unexposed. The number of persons now in each exposure category are 51, 12, 116, and 137, respectively. 100 references, 4 figures, 5 tables. (ACR)

  7. 50 Ways to Prevent Type 2 Diabetes

    2007-11-01

    This podcast delivers a diabetes prevention message tailored for African Americans.  Created: 11/1/2007 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 11/18/2007.

  8. It's Never Too Late To Prevent Diabetes

    2007-11-01

    This podcast delivers a diabetes prevention message tailored for older adults.  Created: 11/1/2007 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 11/20/2007.

  9. Preventing Vision Loss in Diabetes - Summary

    2008-04-24

    This podcast is for a professional audience and briefly discusses how to prevent vision loss in people with diabetes.  Created: 4/24/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Diabetes Translation (DDT), National Diabetes Education Program (NDEP).   Date Released: 6/4/2008.

  10. Preventing Repeat Teen Births PSA (:60)

    2013-04-02

    This 60 second public service announcement is based on the April 2013 CDC Vital Signs report, which discusses repeat teen births and ways teens, parents and guardians, health care providers, and communities can help prevent them.  Created: 4/2/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/2/2013.

  11. Preventing Older Adult Falls and TBI

    2008-03-05

    This podcast provides tips on how older adults can prevent falls and related injuries, such as traumatic brain injuries (TBI).  Created: 3/5/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 3/7/2008.

  12. Fibroelastoma valvular aórtico como causa de accidente cerebrovascular embólico: Reporte de un caso

    Bahamondes S,Juan Carlos; MERIÑO S,GUSTAVO; SALMAN A,JUAN; SILVA V,ABELARDO; MORA M,JAVIER

    2008-01-01

    Los tumores cardíacos son una causa rara de accidente cerebrovascular embólico. Comunicamos el caso de una paciente de 65 años quien debuta su historia con un accidente cerebrovascular. El estudio de fuente embólica con ecocardiografía transesofágica demostró un fibroelastoma de la válvula aórtica en el borde libre del velo no coronariano. El tumor fue extraído mediante circulación extracorpórea. El estudio anatomopatológico confirmó el diagnóstico y la paciente se encuentra en capacidad func...

  13. Accidental ingestion of an inter-occlusal device used for the restoration of occlusion: a case report.

    Vasconcellos, Walison Arthuso; Braga, Neilor Mateus Antunes; Moretzsohn, Luciana Dias; Lanza, Marcos Daniel Septimio; Lanza, Marcos Dias; Rocha, Wellington Márcio dos Santos

    2014-09-01

    The accidental swallowing of prosthetic devices has been discussed in the relevant literature as an unusual, although ordinary, event in clinical practice. This article aims at reporting the ingestion of an inter-occlusal device used to restore the Vertical Dimension of Occlusion (VDO) which, during the ingestion of an analgesic pill, was accidentally swallowed. The patient was sent to the Clinics Hospital UFMG where, upon taking radiographs, the device was located in the upper third of the esophagus. The device was removed during an endoscopic exam with the help of forceps for removing foreign objects. Dealing with a relevant situation, one may conclude that patients who use removable intra-oral devices must take part in a reevaluation protocol in order to detect adaptation and retention of these devices, as well as proper instruction for the patient.

  14. Wandering Fish Bone: a Case of Pelvic Abscess due to Rectum Perforation Resulting from an Accidental Fish Bone Ingestion

    Sirous Abbasi

    2010-09-01

    Full Text Available Fish bone is the most common foreign body that is ingested accidentally and can be caused gastrointestinal complications such as perforation, abstraction, and abscess. We describe a 75-year-old man who suffered from constipation, diarrhea, and fever and chills for 3 months. He had mild tenderness in hypogasteric region and also mild tenderness and swelling on anterior rectal wall and prostate upon clinical examination. The abdominal and pelvic sonography and CT scan findings suggested existence of abscess in the space of between bladder and rectum. The patient underwent laparotomy to drainage the pelvic abscess. The surgeon found a 6-cm fish bone which was embedded in the abscess. The presented case indicated the importance of accidental fish bone ingestion and its possible complications. In addition, the patients with abdominal pain, GI bleeding, and fever of unknown origin living in the seaside regions, the wandering fish bone as a differential diagnosis should be kept in mind.

  15. Clinical Evaluation of Aspirin and Sustained-release Dipyridamole in the Prevention and Treatment of Ischaemic Cerebrovascular Events After Acute Ischemic Stroke%阿司匹林联合缓释型双嘧达莫防治急性缺血性卒中后脑血管缺血事件的临床评价

    冯慧玲; 杨冠涛

    2012-01-01

    目的 评价阿司匹林联合缓释型双嘧达莫防治急性缺血性卒中后脑血管缺血事件的临床作用.方法 选择2009年2月-2012年1月清苑县人民医院收治的63例急性缺血性卒中患者作为研究对象,根据抗血小板治疗药物使用情况分为A组33例和B组30例,A组采用阿司匹林联合缓释型双嘧达莫治疗,B组仅采用阿司匹林治疗,比较两组对脑血管缺血事件的防治作用.结果 A、B两组治疗后的神经功能缺损评分均明显改善,以A组改善更为明显(P<0.05);随访6个月,A组脑血管缺血事件发生率为3.0%,B组为23.3%,组间差异有统计学意义(P<0.05);两组均无严重不良反应发生.结论 阿司匹林联合缓释型双嘧达莫防治急性缺血性卒中后脑血管缺血事件的临床作用显著,能明显改善患者的神经功能,减少脑血管缺血事件的发生,并且安全性好,是临床首选的药物治疗方案之一.%Objective To evaluate the clinical effect of aspirin and sustained - release dipyridamole in the prevention and treatment of ischaemic cerebrovascular events after acute ischemic stroke. Methods From February 2009 to January 2012, 63 patients with acute ischemic stroke in the People's Hospital of Qingyuan County were selected as the research objects. According to the usage of antiplatelet therapy, they were divided into group A (n= 33) and group B (n= 30). The patients in group A were treated with aspirin plus sustained — release dipyridamole, while the patients in group B were only treated with aspirin. The prevention and treatment effects in the two groups were compared. Results After the treatment, the neurological deficit scores of groups A and B were both significantly improved, but the score in group A was improved more significantly (P< 0.05). Six- month follow — up outcome showed that the incidence rates of ischaemic cerebrovascular event in groups A and B were 3.0% and 23.3% respectively, and the difference

  16. OCTAVIO PAZ Y EL ACCIDENTE COMO IMAGEN DEL MUNDO Octavio Paz and the accident as world’s image

    Eduardo Aguayo Rodríguez

    2011-12-01

    Full Text Available Examen del significado de la noción de accidente a partir de una perspectiva amplia que permita integrar antecedentes filológicos, filosóficos e históricos fundamentales. Se analiza la significación del accidente en tanto que imagen de mundo en las sociedades contemporáneas, a partir de una serie de reflexiones teóricas desarrolladas por Octavio Paz durante la década del 60 y, finalmente, se plantean algunas claves que pueden vincular la noción de accidente con la narrativa hispanoamericana del siglo XX.The article deals with the notion of accident from a wide point of view integrating philological, philosophical and historical data. The meaning of accident is analyzed according to the image of the world in the post-industrialized societies, from a set of theorical reflexions developed by Octavio Paz during the 60’s; finally, there is a brief discussion about the possible connections between the notion of accident and the hispanic literacy production in the 20th century, specifically in the field of narrative.

  17. ESTADO ACTUAL DE LA PREVENCIÓN DE LOS ACCIDENTES DE MONTAÑA EN ARAGÓN

    Ma. Antonia Nerín

    2005-01-01

    - Establecer las necesidades de los colectivos implicados (usuarios, profesionales e nstituciones para reducir la incidencia y severidad de los accidentes de montaña. Para ello, hemos utilizado los resultados de las campañas institucionales Montañas para Vivirlas Seguro de los años 2000, 2001 y 2002, se han analizado las ocupaciones relacionadas con las actividades deportivas en la montaña y hemos consultado directamente con las instituciones implicadas. El nivel de formación e información del usuario de la montaña en Aragón no es el adecuado para el riesgo potencial de las actividades de montaña; mientras que se evidencia la necesidad de reglar algunas profesiones de la montaña. El rescate en montaña es efectivo, eficaz y eficiente; la medicalización es efectiva, eficaz y no eficiente (atendiendo a los criterios de necesidad, oferta y demanda y la prevención -a pesar de los esfuerzos- es no eficaz, no eficiente y no efectiva. Por todo ello, es urgente la creaciÛn de un servicio de vigilancia de los accidentes de montaña, así como un centro que coordine las propuestas y actuaciones orientadas a prevenir los acci-dentes de montaña.

  18. Research progress on children accidental injury%儿童意外伤害的研究进展

    李丽; Patricia Ryan-Krause; 李映兰

    2012-01-01

    从流行病学分布、影响因素以及干预措施等方面综合分析国内外对儿童意外伤害的研究现状,发现相对于流行病学研究而言,中低收入国家对儿童意外伤害问题的研究广度及干预项目的有效性研究均较缺乏,未开展意外伤害发生的心理及行为机制研究.%From the epidemiological distribution,influencing factors and interventions it analyzed the research status of children accidental injury in a-broad and at home comprehensively, and found out compared with the epidemiological studies,the research breadth and effective researches of intervention projects on children accidental injury in low - and middle - income countries were lack,and not to carry out a study on the psychological and behavioral mechanisms of accidental injury.

  19. A comparison study on mental health status between suicide survivors and survivors of accidental deaths in rural China.

    Xu, G; Li, N

    2014-12-01

    Suicide has become a major public health problem worldwide. For every suicide there are six suicide survivors, a term referring to family members or friends of a person who has died by suicide. Within the literature there has been ongoing debate regarding the bereavement process and if it differs in survivors of suicide as opposed to survivors of those who have died from accidental death. There are scarcely any published reports on comparison between these two groups of survivors in China. In this study, we aimed to explore the difference of mental health status between suicide survivors and survivors of accidental deaths in China. We used a cross-sectional study design to collect data of survivors. Consecutive sampling was used and 92 suicide survivors and 64 survivors of accidental deaths were interviewed. The Symptom Checklist-90-Revised was used to assess the survivors' mental health status. After controlling for demographic variables and time interval between death and interview, no significant differences were found on mental health status between these two groups of survivors. Several explanations might account for the lack of differences. Further studies employing qualitative measures and suicide-specific instruments are needed to explore the bereavement of Chinese suicide survivors.

  20. Intracellular drug release nanosystems

    Fenghua Meng

    2012-10-01

    Full Text Available In order to elicit therapeutic effects, many drugs including small molecule anticancer drugs, proteins, siRNA, and DNA have to be delivered and released into the specific cellular compartments typically the cytoplasm or nucleus of target cells. Intracellular environment-responsive nanosystems that exhibit good extracellular stability while rapidly releasing drugs inside cancer cells have been actively pursued for effective cancer therapy. Here, we highlight novel designs of smart nanosystems that release drugs in response to an intracellular biological signal of cancer cells such as acidic pH in endo/lysosomal compartments, enzymes in lysosomes, and redox potential in cytoplasm and the cell nucleus.