Strip interpolation in silicon and germanium strip detectors

International Nuclear Information System (INIS)

Wulf, E. A.; Phlips, B. F.; Johnson, W. N.; Kurfess, J. D.; Lister, C. J.; Kondev, F.; Physics; Naval Research Lab.

2004-01-01

The position resolution of double-sided strip detectors is limited by the strip pitch and a reduction in strip pitch necessitates more electronics. Improved position resolution would improve the imaging capabilities of Compton telescopes and PET detectors. Digitizing the preamplifier waveform yields more information than can be extracted with regular shaping electronics. In addition to the energy, depth of interaction, and which strip was hit, the digitized preamplifier signals can locate the interaction position to less than the strip pitch of the detector by looking at induced signals in neighboring strips. This allows the position of the interaction to be interpolated in three dimensions and improve the imaging capabilities of the system. In a 2 mm thick silicon strip detector with a strip pitch of 0.891 mm, strip interpolation located the interaction of 356 keV gamma rays to 0.3 mm FWHM. In a 2 cm thick germanium detector with a strip pitch of 5 mm, strip interpolation of 356 keV gamma rays yielded a position resolution of 1.5 mm FWHM

Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction.

Science.gov (United States)

Lee, Hee Jung; Seo, Seong Rak; Yoon, Moon Soo; Song, Ji-Ye; Lee, Eun Young; Lee, Sang Eun

2016-02-01

Skin aging results in physiological alterations in keratinocyte activities and epidermal function, as well as dermal changes. Yet, the cellular and molecular mechanisms that cause epidermal dysfunction during skin aging are not well understood. Recently, the role of epidermal hyaluronan (HA) as an active regulator of dynamic cellular processes is getting attention and alterations in HA metabolism are thought to be important in age-related epidermal dysfunction. Microneedle fractional radiofrequency (RF) has shown effects for improving cutaneous aging. However, little is known about the effects of fractional RF on the epidermal HA and epidermal function. We investigated the effect of microneedle fractional RF on the expression of epidermal HA in young and aged mice epidermis. We performed fractional RF on the dorsal skin of 30 8-week-old (young) hairless mice and 15 47-week-old (aged) C57BL/6J mice. Skin samples were collected on day 1, 3, and 7. HA content was measured by ELISA. Gene expressions of CD 44, HABP4, and HAS3 were measured using real time RT-PCR. Immunohistochemistry for detection of HA, CD44, PCNA, and filaggrin were performed. HA content and the mRNA levels of HABP4, CD44, and HAS3 were upregulated in the epidermis of both young and aged mice after microneedle fractional RF treatment. The expression was increased from day 1 after treatment and increased expression persisted on day 7. Fractional RF treatment significantly increased PCNA and filaggrin expression only in the aged mice skin. Microneedle fractional RF increased epidermal HA and CD44 expression in both young and aged mice and reversed age-related epidermal dysfunction especially in aged mice, suggesting a new mechanism involved in the skin rejuvenation effect of microneedle fractional RF. © 2015 Wiley Periodicals, Inc.

Microscopic, physicochemical and chromatographic fingerprints of ...

African Journals Online (AJOL)

Polygonal epidermal cells and numerous uniseriate, unicellular trichomes were also present. Quantitative leaf analysis revealed the following: stomata number on abaxial surface 445, stomata index 30.7, palisade ratio 17.1, vein- islet number 17.3 and vein- termination number 14.2. Chemomicroscopic characters present ...

Effects of topical application of aqueous solutions of hexoses on epidermal permeability barrier recovery rate after barrier disruption.

Science.gov (United States)

Denda, Mitsuhiro

2011-11-01

Previous studies have suggested that hexose molecules influence the stability of phospholipid bilayers. Therefore, the effects of topical application of all 12 stereoisomers of dextro-hexose on the epidermal barrier recovery rate after barrier disruption were evaluated. Immediately after tape stripping, 0.1 m aqueous solution of each hexose was applied on hairless mouse skin. Among the eight dextro-aldohexoses, topical application of altose, idose, mannose and talose accelerated the barrier recovery, while allose, galactose, glucose and gulose had no effect. Among the four dextro-ketohexoses, psicose, fructose, sorbose and tagatose all accelerated the barrier recovery. As the effects of hexoses on the barrier recovery rate appeared within 1 h, the mechanism is unlikely to be genomic. Instead, these hexoses may influence phase transition of the lipid bilayers of lamellar bodies and cell membrane, a crucial step in epidermal permeability barrier homeostasis. © 2011 John Wiley & Sons A/S.

Two Nucleolar Proteins, GDP1 and OLI2, Function As Ribosome Biogenesis Factors and Are Preferentially Involved in Promotion of Leaf Cell Proliferation without Strongly Affecting Leaf Adaxial–Abaxial Patterning in Arabidopsis thaliana

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Koji Kojima

2018-01-01

Full Text Available Leaf abaxial–adaxial patterning is dependent on the mutual repression of leaf polarity genes expressed either adaxially or abaxially. In Arabidopsis thaliana, this process is strongly affected by mutations in ribosomal protein genes and in ribosome biogenesis genes in a sensitized genetic background, such as asymmetric leaves2 (as2. Most ribosome-related mutants by themselves do not show leaf abaxialization, and one of their typical phenotypes is the formation of pointed rather than rounded leaves. In this study, we characterized two ribosome-related mutants to understand how ribosome biogenesis is linked to several aspects of leaf development. Previously, we isolated oligocellula2 (oli2 which exhibits the pointed-leaf phenotype and has a cell proliferation defect. OLI2 encodes a homolog of Nop2 in Saccharomyces cerevisiae, a ribosome biogenesis factor involved in pre-60S subunit maturation. In this study, we found another pointed-leaf mutant that carries a mutation in a gene encoding an uncharacterized protein with a G-patch domain. Similar to oli2, this mutant, named g-patch domain protein1 (gdp1, has a reduced number of leaf cells. In addition, gdp1 oli2 double mutants showed a strong genetic interaction such that they synergistically impaired cell proliferation in leaves and produced markedly larger cells. On the other hand, they showed additive phenotypes when combined with several known ribosomal protein mutants. Furthermore, these mutants have a defect in pre-rRNA processing. GDP1 and OLI2 are strongly expressed in tissues with high cell proliferation activity, and GDP1-GFP and GFP-OLI2 are localized in the nucleolus. These results suggest that OLI2 and GDP1 are involved in ribosome biogenesis. We then examined the effects of gdp1 and oli2 on adaxial–abaxial patterning by crossing them with as2. Interestingly, neither gdp1 nor oli2 strongly enhanced the leaf polarity defect of as2. Similar results were obtained with as2 gdp1 oli2

[Progress in epidermal stem cells].

Science.gov (United States)

Wang, Li-Juan; Wang, You-Liang; Yang, Xiao

2010-03-01

Mammalian skin epidermis contains different epidermal stem cell pools which contribute to the homeostasis and repair of skin epithelium. Epidermal stem cells possess two essential features common to all stem cells: self-renewal and differentiation. Disturbing the balance between self-renewal and differentiation of epidermal stem cell often causes tumors or other skin diseases. Epidermal stem cell niches provide a special microenvironment that maintains a balance of stem cell quiescence and activity. This review primarily concentrates on the following points of the epidermal stem cells: the existing evidences, the self-renewal and differentiation, the division pattern, the signal pathways regulating self-renewal and differentiation, and the microenvironment (niche) and macroenvironment maintaining the homeostasis of stem cells.

Model for prediction of strip temperature in hot strip steel mill

International Nuclear Information System (INIS)

Panjkovic, Vladimir

2007-01-01

Proper functioning of set-up models in a hot strip steel mill requires reliable prediction of strip temperature. Temperature prediction is particularly important for accurate calculation of rolling force because of strong dependence of yield stress and strip microstructure on temperature. A comprehensive model was developed to replace an obsolete model in the Western Port hot strip mill of BlueScope Steel. The new model predicts the strip temperature evolution from the roughing mill exit to the finishing mill exit. It takes into account the radiative and convective heat losses, forced flow boiling and film boiling of water at strip surface, deformation heat in the roll gap, frictional sliding heat, heat of scale formation and the heat transfer between strip and work rolls through an oxide layer. The significance of phase transformation was also investigated. Model was tested with plant measurements and benchmarked against other models in the literature, and its performance was very good

Model for prediction of strip temperature in hot strip steel mill

Energy Technology Data Exchange (ETDEWEB)

Panjkovic, Vladimir [BlueScope Steel, TEOB, 1 Bayview Road, Hastings Vic. 3915 (Australia)]. E-mail: Vladimir.Panjkovic@BlueScopeSteel.com

2007-10-15

Proper functioning of set-up models in a hot strip steel mill requires reliable prediction of strip temperature. Temperature prediction is particularly important for accurate calculation of rolling force because of strong dependence of yield stress and strip microstructure on temperature. A comprehensive model was developed to replace an obsolete model in the Western Port hot strip mill of BlueScope Steel. The new model predicts the strip temperature evolution from the roughing mill exit to the finishing mill exit. It takes into account the radiative and convective heat losses, forced flow boiling and film boiling of water at strip surface, deformation heat in the roll gap, frictional sliding heat, heat of scale formation and the heat transfer between strip and work rolls through an oxide layer. The significance of phase transformation was also investigated. Model was tested with plant measurements and benchmarked against other models in the literature, and its performance was very good.

SlLAX1 is Required for Normal Leaf Development Mediated by Balanced Adaxial and Abaxial Pavement Cell Growth in Tomato.

Science.gov (United States)

Pulungan, Sri Imriani; Yano, Ryoichi; Okabe, Yoshihiro; Ichino, Takuji; Kojima, Mikiko; Takebayashi, Yumiko; Sakakibara, Hitoshi; Ariizumi, Tohru; Ezura, Hiroshi

2018-06-01

Leaves are the major plant organs with a primary function for photosynthesis. Auxin controls various aspects of plant growth and development, including leaf initiation, expansion and differentiation. Unique and intriguing auxin features include its polar transport, which is mainly controlled by the AUX1/LAX and PIN gene families as influx and efflux carriers, respectively. The role of AUX1/LAX genes in root development is well documented, but the role of these genes in leaf morphogenesis remains unclear. Moreover, most studies have been conducted in the plant model Arabidopsis thaliana, while studies in tomato are still scarce. In this study, we isolated six lines of the allelic curly leaf phenotype 'curl' mutants from a γ-ray and EMS (ethyl methanesulfonate) mutagenized population. Using a map-based cloning strategy combined with exome sequencing, we observed that a mutation occurred in the SlLAX1 gene (Solyc09g014380), which is homologous to an Arabidopsis auxin influx carrier gene, AUX1 (AtAUX1). Characterization of six alleles of single curl mutants revealed the pivotal role of SlLAX1 in controlling tomato leaf flatness by balancing adaxial and abaxial pavement cell growth, which has not been reported in tomato. Using TILLING (Targeting Induced Local Lesions IN Genome) technology, we isolated an additional mutant allele of the SlLAX1 gene and this mutant showed a curled leaf phenotype similar to other curl mutants, suggesting that Solyc09g014380 is responsible for the curl phenotype. These results showed that SlLAX1 is required for normal leaf development mediated by balanced adaxial and abaxial pavement cell growth in tomato.

Epidermal Inclusion Cysts of The Breast

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Amir R. Motabar

2009-02-01

Full Text Available Epidermal inclusion cysts are uncommon in the breast, but the consequences can besevere when these cysts occur in the breast parenchyma. Here,we report two suchcases. The patient in case 1 was an 37-year-old woman with a 3-cm palpable mass inthe right breast. Mammography revealed a round and smoothly outlined mass, whichindicated a benign tumor, and sonography showed an irregularly shaped and heterogeneoushypoechoic mass, fibroadenoma was suspected on the basis of clinical andimage findings, but excisional biopsy revealed an epidermal inclusion cyst. The patientin case 2 was a 50-year-old woman with a 2.5-cm lesion in the left breast. Mammographyrevealed a round, dense, smoothly outlined mass, and sonography showeda well-defined, central hyperechoic mass. . Breast cancer was suspected on the basisof the sonographic findings and the age of the patient, but the resected specimen revealedan epidermal inclusion cyst. Although epidermal inclusion cysts are benign,occasionally they may play a role in the origin of squamous carcinoma of the breast. .Mammographic and sonographic features of an epidermal cyst may mimic a malignantlesion. Malignant change appears to occur more frequently in epidermal inclusioncysts in the mammary gland, compared to common epidermal inclusion cysts,and this may be associated with origination of mammary epidermal inclusion cystsfrom squamous metaplasia of the mammary duct epithelium.Epidermmoid inclusion cyst of the breast is potentially serious, although such cystsare rare, and differentiation from a malignant or benign breast tumor is required. Excisionis probably the most appropriate treatment, and can eliminate the possible riskof malignant transformation.

Epidermal growth factor and insulin-like growth factor I upregulate the expression of the epidermal growth factor system in rat liver

DEFF Research Database (Denmark)

Bor, M V; Sørensen, B S; Vinter-Jensen, L

2000-01-01

BACKGROUND/AIM: Both epidermal growth factor and insulin-like growth factor I play a role in connection with the liver. In the present study, the possible interaction of these two growth factor systems was studied by investigating the effect of epidermal growth factor or insulin-like growth factor...... I treatment on the expression of the epidermal growth factor receptor, and its activating ligands, transforming growth factor-alpha and epidermal growth factor. METHODS: Fifty-five male rats received no treatment, human recombinant epidermal growth factor or human recombinant insulin-like growth.......8+/-1.6 fmol/mg protein epidermal growth factor and 144+/-22 fmol/mg protein transforming growth factor-alpha. Both epidermal growth factor and insulin-like growth factor I treatment increased the expression of mRNA for transforming growth factor-alpha and epidermal growth factor receptor, as well...

Quantitative comparison of 3 enamel-stripping devices in vitro: how precisely can we strip teeth?

Science.gov (United States)

Johner, Alexander Marc; Pandis, Nikolaos; Dudic, Alexander; Kiliaridis, Stavros

2013-04-01

In this in-vitro study, we aimed to investigate the predictability of the expected amount of stripping using 3 common stripping devices on premolars. One hundred eighty extracted premolars were mounted and aligned in silicone. Tooth mobility was tested with Periotest (Medizintechnik Gulden, Modautal, Germany) (8.3 ± 2.8 units). The selected methods for interproximal enamel reduction were hand-pulled strips (Horico, Hapf Ringleb & Company, Berlin, Germany), oscillating segmental disks (O-drive-OD 30; KaVo Dental, Biberach, Germany), and motor-driven abrasive strips (Orthofile; SDC Switzerland, Lugano-Grancia, Switzerland). With each device, the operator intended to strip 0.1, 0.2, 0.3, or 0.4 mm on the mesial side of 15 teeth. The teeth were scanned before and after stripping with a 3-dimensional laser scanner. Superposition and measurement of stripped enamel on the most mesial point of the tooth were conducted with Viewbox software (dHal Software, Kifissia, Greece). The Wilcoxon signed rank test and the Kruskal-Wallis test were applied; statistical significance was set at alpha ≤ 0.05. Large variations between the intended and the actual amounts of stripped enamel, and between stripping procedures, were observed. Significant differences were found at 0.1 mm of intended stripping (P ≤ 0.05) for the hand-pulled method and at 0.4 mm of intended stripping (P ≤ 0.001 to P = 0.05) for all methods. For all scenarios of enamel reduction, the actual amount of stripping was less than the predetermined and expected amount of stripping. The Kruskal-Wallis analysis showed no significant differences between the 3 methods. There were variations in the stripped amounts of enamel, and the stripping technique did not appear to be a significant predictor of the actual amount of enamel reduction. In most cases, actual stripping was less than the intended amount of enamel reduction. Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights

Stripping Voltammetry

Science.gov (United States)

Lovrić, Milivoj

Electrochemical stripping means the oxidative or reductive removal of atoms, ions, or compounds from an electrode surface (or from the electrode body, as in the case of liquid mercury electrodes with dissolved metals) [1-5]. In general, these atoms, ions, or compounds have been preliminarily immobilized on the surface of an inert electrode (or within it) as the result of a preconcentration step, while the products of the electrochemical stripping will dissolve in the electrolytic solution. Often the product of the electrochemical stripping is identical to the analyte before the preconcentration. However, there are exemptions to these rules. Electroanalytical stripping methods comprise two steps: first, the accumulation of a dissolved analyte onto, or in, the working electrode, and, second, the subsequent stripping of the accumulated substance by a voltammetric [3, 5], potentiometric [6, 7], or coulometric [8] technique. In stripping voltammetry, the condition is that there are two independent linear relationships: the first one between the activity of accumulated substance and the concentration of analyte in the sample, and the second between the maximum stripping current and the accumulated substance activity. Hence, a cumulative linear relationship between the maximum response and the analyte concentration exists. However, the electrode capacity for the analyte accumulation is limited and the condition of linearity is satisfied only well below the electrode saturation. For this reason, stripping voltammetry is used mainly in trace analysis. The limit of detection depends on the factor of proportionality between the activity of the accumulated substance and the bulk concentration of the analyte. This factor is a constant in the case of a chemical accumulation, but for electrochemical accumulation it depends on the electrode potential. The factor of proportionality between the maximum stripping current and the analyte concentration is rarely known exactly. In fact

MORPHOLOGICAL ANALYSIS OF THE LEAVES OF Anacardium occidentale L.

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Glenda Quaresma Ramos

2016-03-01

Full Text Available In morphological studies are analyzed various parameters, ranging from macro scale through the micro scale to the nanometer scale, which contribute to the study of taxonomy, pharmacognosy, ecology, among others. Among the structures found in plants, the leaves are most organs analyzed. This study aimed to analyze morphological features of the leaves of the cashew tree, which is a plant of great commercial importance in Brazil. In this work we observed sinuous epidermal cells in the adaxial and abaxial, characterize their stomata in paracytic surrounded subsidiaries cells. On the abaxial surface the presence of glandular trichomes was observed; and cross-sectional analysis showed a single-layered epidermis with compact mesophyll and several layers of parenchyma cells. Keywords: leaf anatomy; cashew tree; optical microscopy.

UVB-induced epidermal hyperproliferation is modified by a single, topical treatment with a mitosis inhibitory epidermal pentapeptide

International Nuclear Information System (INIS)

Olsen, W.M.; Elgjo, K.

1990-01-01

A single application of a water-miscible cream base containing the recently identified mitosis inhibitory epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH (EPP) to hairless mouse skin is followed by a long-lasting period of reduced epidermal cell proliferation. To examine if a similar growth inhibition could be achieved in stimulated and rapidly proliferating epidermis, EPP was applied at two different concentrations, 0.005 or 0.02%, to hairless mouse skin immediately after exposure of the left flank to an erythemic dose of ultraviolet B light (UVB). This dose of UVB alone induces a sustained period of rapid epidermal cell proliferation, starting at about 18 h after the irradiation. Epidermal cell proliferation was followed from 18 to 54 h (0.005% cream) or from 18 to 30 h (0.02% cream) after the treatment by estimating the rate of G2-M cell flux (the mitotic rate) by means of Colcemid, and epidermal DNA synthesis by counting labeled cells after pulse-labeling with 3H-thymidine. The unirradiated side of the mice was used as reference. The results showed that topical treatment with a 0.02% EPP cream partially inhibited UVB-induced epidermal hyperproliferation, while the 0.005% EPP cream inhibited as well as stimulated the UVB-induced hyperproliferation. Thus, EPP is effective even in rapidly proliferating epidermal cell populations, but the outcome is obviously dose-dependent in this test system

Diferenciação entre Egeria densa e Egeria najas pelos caracteres anatômicos foliares Differentiation between Egeria densa and Egeria najas by leaf anatomic characters

Directory of Open Access Journals (Sweden)

R.A. Rodella

2006-06-01

Full Text Available Dentre as plantas daninhas aquáticas imersas de maior importância nos reservatórios de usinas hidrelétricas e em represas de pequeno porte no Brasil, destacam-se as espécies Egeria densa e Egeria najas, cuja identificação pode ser difícil na fase vegetativa. O objetivo deste trabalho foi diferenciar cinco acessos de E. densa e três de E. najas, coletados nos reservatórios de Jupiá, Salto Grande, Três Irmãos, Promissão, Nova Avanhandava e Ibitinga, do complexo da Companhia Energética de São Paulo (CESP do Estado de São Paulo, quanto às características anatômicas descritivas e quantitativas do limbo foliar, procurando-se obter melhor entendimento sobre as relações dessas estruturas anatômicas com a penetração e translocação de herbicidas, além de auxiliar na identificação de acessos suscetíveis e resistentes a determinado produto químico. Amostras do terço médio do limbo foram fixadas em FAA 50, cortadas transversalmente em micrótomo rotatório com 8 mm de espessura e coradas com azul-de-toluidina. Foi analisada a estrutura foliar e foram quantificados os caracteres anatômicos da nervura central (% epiderme das faces adaxial e abaxial, % feixe vascular e % parênquima e da região situada entre a nervura e o bordo do limbo (% epiderme das faces adaxial e abaxial e espessura da folha. Os dados das variáveis quantitativas foram submetidos aos testes estatísticos multivariados de Análise de Agrupamento e Análise de Componentes Principais. Houve formação de três grupos principais: o primeiro foi constituído pelos três acessos de E. najas; o segundo, por quatro acessos de E. densa; e o terceiro, por apenas um acesso de E. densa. O caráter que mais contribuiu para a diferenciação entre os acessos foi a % feixe vascular da nervura central, seguido da % epiderme da face abaxial da nervura central e % epiderme das faces adaxial e abaxial da região entre a nervura e o bordo foliar. Concluiu-se que a utiliza

Varicose vein stripping

Science.gov (United States)

... stripping; Venous reflux - vein stripping; Venous ulcer - veins Patient Instructions Surgical wound care - open Varicose veins - what to ask your doctor Images Circulatory system References American Family Physician. Management of varicose veins. www.aafp.org/afp/2008/ ...

Oral mucosa: an alternative epidermic cell source to develop autologous dermal-epidermal substitutes from diabetic subjects

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Daniela GUZMÁN-URIBE

Full Text Available Abstract Oral mucosa has been highlighted as a suitable source of epidermal cells due to its intrinsic characteristics such as its higher proliferation rate and its obtainability. Diabetic ulcers have a worldwide prevalence that is variable (1%-11%, meanwhile treatment of this has been proven ineffective. Tissue-engineered skin plays an important role in wound care focusing on strategies such autologous dermal-epidermal substitutes. Objective The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. Material and Methods Oral mucosa was obtained from diabetic and healthy subjects (n=20 per group. Epidermal cells were isolated and cultured using autologous fibrin to develop dermal-epidermal in vitro substitutes by the air-liquid technique with autologous human serum as a supplement media. Substitutes were immunocharacterized with collagen IV and cytokeratin 5-14 as specific markers. A Student´s t- test was performed to assess the differences between both groups. Results It was possible to isolate epidermal cells from the oral mucosa of diabetic and healthy subjects and develop autologous dermal-epidermal skin substitutes using autologous serum as a supplement. Differences in the expression of specific markers were observed and the cytokeratin 5-14 expression was lower in the diabetic substitutes, and the collagen IV expression was higher in the diabetic substitutes when compared with the healthy group, showing a significant difference. Conclusion Cells from oral mucosa could be an alternative and less invasive source for skin substitutes and wound healing. A difference in collagen production of diabetic cells suggests diabetic substitutes could improve diabetic wound healing. More research is needed to determine the crosstalk between components of these skin substitutes and damaged tissues.

Testbeam evaluation of silicon strip modules for ATLAS Phase - II Strip Tracker Upgrade

CERN Document Server

Blue, Andrew; The ATLAS collaboration; Ai, Xiaocong; Allport, Phillip; Arling, Jan-Hendrik; Atkin, Ryan Justin; Bruni, Lucrezia Stella; Carli, Ina; Casse, Gianluigi; Chen, Liejian; Chisholm, Andrew; Cormier, Kyle James Read; Cunningham, William Reilly; Dervan, Paul; Diez Cornell, Sergio; Dolezal, Zdenek; Dopke, Jens; Dreyer, Etienne; Dreyling-Eschweiler, Jan Linus Roderik; Escobar, Carlos; Fabiani, Veronica; Fadeyev, Vitaliy; Fernandez Tejero, Javier; Fleta Corral, Maria Celeste; Gallop, Bruce; Garcia-Argos, Carlos; Greenall, Ashley; Gregor, Ingrid-Maria; Greig, Graham George; Guescini, Francesco; Hara, Kazuhiko; Hauser, Marc Manuel; Huang, Yanping; Hunter, Robert Francis Holub; Keller, John; Klein, Christoph; Kodys, Peter; Koffas, Thomas; Kotek, Zdenek; Kroll, Jiri; Kuehn, Susanne; Lee, Steven Juhyung; Liu, Yi; Lohwasser, Kristin; Meszarosova, Lucia; Mikestikova, Marcela; Mi\\~nano Moya, Mercedes; Mori, Riccardo; Moser, Brian; Nikolopoulos, Konstantinos; Peschke, Richard; Pezzullo, Giuseppe; Phillips, Peter William; Poley, Anne-luise; Queitsch-Maitland, Michaela; Ravotti, Federico; Rodriguez Rodriguez, Daniel

2018-01-01

The planned HL-LHC (High Luminosity LHC) is being designed to maximise the physics potential of the LHC with 10 years of operation at instantaneous luminosities of \\mbox{$7.5\\times10^{34}\\;\\mathrm{cm}^{-2}\\mathrm{s}^{-1}$}. A consequence of this increased luminosity is the expected radiation damage requiring the tracking detectors to withstand hadron equivalences to over $1x10^{15}$ 1 MeV neutron equivalent per $cm^{2}$ in the ATLAS Strips system. The silicon strip tracker exploits the concept of modularity. Fast readout electronics, deploying 130nm CMOS front-end electronics are glued on top of a silicon sensor to make a module. The radiation hard n-in-p micro-strip sensors used have been developed by the ATLAS ITk Strip Sensor collaboration and produced by Hamamatsu Photonics. A series of tests were performed at the DESY-II test beam facility to investigate the detailed performance of a strip module with both 2.5cm and 5cm length strips before irradiation. The DURANTA telescope was used to obtain a pointing...

Anatomy Comic Strips

Science.gov (United States)

Park, Jin Seo; Kim, Dae Hyun; Chung, Min Suk

2011-01-01

Comics are powerful visual messages that convey immediate visceral meaning in ways that conventional texts often cannot. This article's authors created comic strips to teach anatomy more interestingly and effectively. Four-frame comic strips were conceptualized from a set of anatomy-related humorous stories gathered from the authors' collective…

Diferenciação de espécies daninhas aquáticas pela análise multivariada de caracteres estruturais foliares Differentiation of aquatic weeds by multivariate analysis of foliar structural characters

Directory of Open Access Journals (Sweden)

N.V. Costa

2006-01-01

Full Text Available Algumas espécies de plantas aquáticas têm-se tornado problemáticas em reservatórios hidrelétricos no Brasil, devido a sua grande capacidade de reprodução. O objetivo destes trabalho foi diferenciar Brachiaria mutica, Brachiaria subquadripara, Panicum repens, Eichhornia crassipes, Heteranthera reniformis, Typha ubulata e Enhydra anagallis, utilizando-se 19 caracteres estruturais quantitativos do limbo foliar, que se relacionassem com a penetração e translocação de herbicidas. Amostras do terço médio do limbo foram fixadas em FAA 50, cortadas transversalmente em micrótomo com 8 mm de espessura e coradas com azul-de-toluidina. Foram quantificados (% os seguintes caracteres estruturais da nervura central (NC e da região internervural (IN: epidermes adaxial e abaxial, feixe vascular, bainha do feixe vascular, esclerênquima, parênquima e lacunas do aerênquima, além da espessura da folha, do número de estômatos e do número de tricomas nas faces adaxial e abaxial. Os 19 caracteres estruturais foram submetidos à Análise de Agrupamento e Análise de Componentes Principais. Houve a formação de três grupos principais: grupo 1 B. mutica, B. subquadripara e P. repens (Poaceae; grupo 2 E. crassipes e H. reniformis (Pontederiaceae e E. anagallis (Asteraceae; e grupo 3 apenas T. subulata (Typhaceae. Os caracteres com maior poder discriminatório foram: porcentagem de epiderme adaxial (IN; porcentagem de epiderme abaxial; feixe vascular; bainha do feixe vascular; esclerênquima e lacunas do aerênquima (NC e IN; espessura da folha e número de estômatos das faces adaxial e abaxial. Concluiu-se que os caracteres estruturais quantitativos permitiram diferenciar essas espécies daninhas aquáticas em fase vegetativa.Some aquatic plant species have caused great damage to hydroelectric power dams in Brazil, due to their great capacity of reproduction. Nineteen quantitative structural characters of leaf blades were used to differentiate

Science Comic Strips

Science.gov (United States)

Kim, Dae Hyun; Jang, Hae Gwon; Shin, Dong Sun; Kim, Sun-Ja; Yoo, Chang Young; Chung, Min Suk

2012-01-01

Science comic strips entitled Dr. Scifun were planned to promote science jobs and studies among professionals (scientists, graduate and undergraduate students) and children. To this end, the authors collected intriguing science stories as the basis of scenarios, and drew four-cut comic strips, first on paper and subsequently as computer files.…

The Strip Module

DEFF Research Database (Denmark)

Pedersen, Tommy

1996-01-01

When the behaviour of a ship in waves is to be predicted it is convenient to have a tool which includes different approaches to the problem.The aim of this project is to develop such a tool named the strip theory module. The strip theory module will consist of submodules dependent on the I...

Nuclear reactor spring strip grid spacer

International Nuclear Information System (INIS)

Patterson, J.F.; Flora, B.S.

1978-01-01

A bimetallic grid spacer is described comprising a grid structure of zircaloy formed by intersecting striplike members which define fuel element openings for receiving fuel elements and spring strips made of Inconel positioned within the grid structure for cooperating with the fuel elements to maintain them in their desired position. A plurality of these spring strips extend longitudinally between sides of the grid structure, being locked in position by the grid retaining strips. The fuel rods, which are disposed in the fuel openings formed in the grid structure, are positioned by means of the springs associated with the spring strips and a plurality of dimples which extend from the zircaloy grid structure into the openings. In one embodiment the strips are disposed in a plurality of arrays with those spring strip arrays situated in opposing diagonal quadrants of the grid structure extending in the same direction and adjacent spring strip arrays in each half of the spacer extending in relatively perpendicular directions. Other variations of the spring strip arrangements for a particular fuel design are disclosed herein

Herbal medicines that benefit epidermal permeability barrier function

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Lizhi Hu

2015-06-01

Full Text Available Epidermal permeability barrier function plays a critical role in regulating cutaneous functions. Hence, researchers have been searching for effective and affordable regimens to enhance epidermal permeability barrier function. In addition to topical stratum corneum lipids, peroxisome proliferator-activated receptor, and liver X receptor ligands, herbal medicines have been proven to benefit epidermal permeability barrier function in both normal and diseased skin, including atopic dermatitis, glucocorticoid-induced skin damage, and UVB-damaged skin. The potential mechanisms by which herbal medicines improve the permeability barrier include stimulation of epidermal differentiation, lipid production, antimicrobial peptide expression, and antioxidation. Therefore, utilization of herbal medicines could be a valuable alternative approach to enhance epidermal permeability barrier function in order to prevent and/or treat skin disorders associated with permeability barrier abnormalities.

Noise analysis due to strip resistance in the ATLAS SCT silicon strip module

International Nuclear Information System (INIS)

Kipnis, I.

1996-08-01

The module is made out of four 6 cm x 6 cm single sided Si microstrip detectors. Two detectors are butt glued to form a 12 cm long mechanical unit and strips of the two detectors are electrically connected to form 12 cm long strips. The butt gluing is followed by a back to back attachment. The module in this note is the Rφ module where the electronics is oriented parallel to the strip direction and bonded directly to the strips. This module concept provides the maximum signal-to-noise ratio, particularly when the front-end electronics is placed near the middle rather than at the end. From the noise analysis, it is concluded that the worst-case ΔENC (far-end injection) between end- and center-tapped modules will be 120 to 210 el. rms (9 to 15%) for a non-irradiated detector and 75 to 130 el. rms (5 to 9%) for an irradiated detector, for a metal strip resistance of 10 to 20 Ω/cm

Area specific stripping factors for AGS. A method for extracting stripping factors from survey data

Energy Technology Data Exchange (ETDEWEB)

Aage, H.K.; Korsbech, U. [Technical Univ. of Denmark (Denmark)

2006-04-15

In order to use Airborne Gamma-ray Spectrometry (AGS) for contamination mapping, for source search etc. one must to be able to eliminate the contribution to the spectra from natural radioactivity. This in general is done by a stripping technique. The parameters for performing a stripping have until recently been measured by recording gamma spectra at special calibration sites (pads). This may be cumbersome and the parameters may not be correct when used at low gamma energies for environmental spectra. During 2000-2001 DTU tested with success a new technique for Carborne Gamma-ray Spectrometry (CGS) where the spectra from the surveyed area (or from a similar area) were used for calculating the stripping parameters. It was possible to calculate usable stripping ratios for a number of low energy windows - and weak source signals not detectable by other means were discovered with the ASS technique. In this report it is shown that the ASS technique also works for AGS data, and it has been used for recent Danish AGS tests with point sources. (Check of calibration of AGS parameters.) By using the ASS technique with the Boden data (Barents Rescue) an exercise source was detected that has not been detected by any of the teams during the exercise. The ASS technique therefore seems to be better for search for radiation anomalies than any other method known presently. The experiences also tell that although the stripping can be performed correctly at any altitude there is a variation of the stripping parameters with altitude that has not yet been quite understood. However, even with the oddly variations the stripping worked as expected. It was also observed that one might calculate a single common set of usable stripping factors for all altitudes from the entire data set i.e. some average a, b and c values. When those stripping factors were used the stripping technique still worked well. (au)

Strip casting apparatus and method

Science.gov (United States)

Williams, R.S.; Baker, D.F.

1988-09-20

Strip casting apparatus including a molten-metal-holding container and a nozzle to deposit molten metal onto a moving chill drum to directly cast continuous metallic strip. The nozzle body includes a slot bounded between a back and a front lip. The slot width exceeds about 20 times the gap distance between the nozzle and the chill drum surface. Preferably, the slot width exceeds 0.5 inch. This method of strip casting minimizes pressure drop, insuring better metal-to-chill-drum contact which promotes heat transfer and results in a better quality metallic strip. 6 figs.

Epidermal stem cells: location, potential and contribution to cancer.

Science.gov (United States)

Ambler, C A; Määttä, A

2009-01-01

Epidermal stem cells have been classically characterized as slow-cycling, long-lived cells that reside in discrete niches in the skin. Gene expression studies of niche-resident cells have revealed a number of stem cell markers and regulators, including the Wnt/beta-catenin, Notch, p63, c-Myc and Hedgehog pathways. A new study challenges the traditional developmental paradigm of slow-cycling stem cells and rapid-cycling transit amplifying cells in some epidermal regions, and there is mounting evidence to suggest that multi-lineage epidermal progenitors can be isolated from highly proliferative, non-niche regions. Whether there is a unique microenvironment surrounding these progenitors remains to be determined. Interestingly, cancer stem cells derived from epidermal tumours exist independent of the classic skin stem cell niche, yet also have stem cell properties, including multi-lineage differentiation. This review summarizes recent studies identifying the location and regulators of mouse and human epidermal stem cells and highlights the strategies used to identify cancer stem cells, including expression of normal epidermal stem cell markers, expression of cancer stem cell markers identified in other epidermal tumours and characterization of side-population tumour cells.

The Honeycomb Strip Chamber

International Nuclear Information System (INIS)

Graaf, Harry van der; Buskens, Joop; Rewiersma, Paul; Koenig, Adriaan; Wijnen, Thei

1991-06-01

The Honeycomb Strip Chamber (HSC) is a new position sensitive detector. It consists of a stack of folded foils, forming a rigid honeycomb structure. In the centre of each hexagonal cell a wire is strung. Conducting strips on the foils, perpendicular to the wires, pick up the induced avalanche charge. Test results of a prototype show that processing the signals form three adjacent strips nearest to the track gives a spatial resolution better than 64 μm for perpendicular incident tracks. The chamber performance is only slightly affected by a magnetic field. (author). 25 refs.; 21 figs

Extraction of high-quality epidermal RNA after ammonium thiocyanate-induced dermo-epidermal separation of 4 mm human skin biopsies

DEFF Research Database (Denmark)

Clemmensen, Anders; Thomassen, Mads; Clemmensen, Ole

2009-01-01

To obtain a separation of the epidermal and dermal compartments to examine compartment specific biological mechanisms in the skin, we incubated 4 mm human skin punch biopsies in ammonium thiocyanate. We wanted to test (i) the histological quality of the dermo-epidermal separation obtained...... by different incubation times; (ii) the amount and quality of extractable epidermal RNA and (iii) its impact on sample RNA expression profiles assessed by large-scale gene expression microarray analysis in both normal and inflamed skin. At 30-min incubation, the split between dermis and epidermis...... and almost completely separated from the dermis of 4 mm skin biopsies by 30 min incubation in 3.8% ammonium thiocyanate combined with curettage of the dermal surface, producing high-quality RNA suitable for transcriptional analysis. Our refined method of dermo-epidermal separation will undoubtedly prove...

Anatomia, ultra-estrutura e secreção do nectário extrafloral de Hibiscus pernambucensis Arruda (Malvaceae)

OpenAIRE

Rocha, Joecildo Francisco; Machado, Silvia Rodrigues [UNESP

2009-01-01

This paper reports on the extrafloral nectary (EFN) of Hibiscus pernambucensis, a native shrub species occurring in mangrove and restinga along Brazil's coastline. EFNs occur as furrows with a protuberant border on the abaxial surface veins of the leaf blade. Each nectary consists of numerous secretory multicellular trichomes, epidermal cells in palisade-like arrangements and non-vascularized parenchyma tissue. Nectar secretion is prolonged, since secretion starts in very young leaves and rem...

Early detection of injuries in leaves of Clusia hilariana Schltdl. (Clusiaceae caused by particulate deposition of iron

Directory of Open Access Journals (Sweden)

Diego Ismael Rocha

2014-06-01

Full Text Available This study aims to evaluate the prognostic value of microscopic parameters of asymptomatic leaves of Clusia hilariana Schltdl. subjected to particulate deposition of iron (2.14 mg cm-2 day-1 for 45 consecutive days. Samples of young and expanded leaves without symptoms were collected and subjected to light and scanning electron microscopy techniques. The height of the epidermal cells on both surfaces of the leaf and the thickness of the hypodermis, the chlorophyll parenchyma, and the leaf blade were measured. Micromorphological injury occurred in the abaxial surface of young leaves and on both surfaces of expanded leaves. Erosion of the epicuticular wax and cuticle rupture were frequent on the adaxial surface, while on the abaxial surface of both leaves there was a loss of sinuosity on the anticlinal wall of the epidermal cells, stomatal deformity and obstruction. Micromorphometric alterations were seen in all leaf tissues except in the height of epidermic cells, probably due to the thick cuticle and prominent cuticular flanges. The highest difference in thickness of the leaf blade was seen in young leaves of plants subjected to SPMFe, indicating greater sensibility to particulate iron in comparison to the expanded leaves. The micromorphological and micromorphometric alterations in the leaf blade of Clusia hilariana Schltdl. showed the prognostic potential of these tools on the evaluation of impacts caused by the deposition of particulate matter, especially in the 'Restinga' natural vegetation, where the exposure is increasing due to the presence of iron ore industry in their surroundings.

Selective chemical stripping

Science.gov (United States)

Malavallon, Olivier

1995-04-01

At the end of the 80's, some of the large European airlines expressed a wish for paint systems with improved strippability on their aircraft, allowing the possibility to strip down to the primer without altering it, using 'mild' chemical strippers based on methylene chloride. These improvements were initially intended to reduce costs and stripping cycle times while facilitating rapid repainting, and this without the need to change the conventionally used industrial facilities. The level of in-service performance of these paint systems was to be the same as the previous ones. Requirements related to hygiene safety and the environment were added to these initial requirements. To meet customers' expectations, Aerospatiale, within the Airbus Industry GIE, formed a work group. This group was given the task of specifying, following up the elaboration and qualifying the paint systems allowing requirements to be met, in relation with the paint suppliers and the airlines. The analysis made in this report showed the interest of transferring as far upstream as possible (to paint conception level) most of the technical constraints related to stripping. Thus, the concept retained for the paint system, allowing selective chemical stripping, is a 3-coat system with characteristics as near as possible to the previously used paints.

Charge collection in silicon strip detectors

International Nuclear Information System (INIS)

Kraner, H.W.; Beuttenmuller, R.; Ludlam, T.; Hanson, A.L.; Jones, K.W.; Radeka, V.; Heijne, E.H.M.

1982-11-01

The use of position sensitive silicon detectors as very high resolution tracking devices in high energy physics experiments has been a subject of intense development over the past few years. Typical applications call for the detection of minimum ionizing particles with position measurement accuracy of 10 μm in each detector plane. The most straightforward detector geometry is that in which one of the collecting electrodes is subdivided into closely spaced strips, giving a high degree of segmentation in one coordinate. Each strip may be read out as a separate detection element, or, alternatively, resistive and/or capacitive coupling between adjacent strips may be exploited to interpolate the position via charge division measrurements. With readout techniques that couple several strips, the numer of readout channels can, in principle, be reduced by large factors without sacrificing the intrinsic position accuracy. The testing of individual strip properties and charge division between strips has been carried out with minimum ionizing particles or beams for the most part except in one case which used alphs particless scans. This paper describes the use of a highly collimated MeV proton beam for studies of the position sensing properties of representative one dimensional strip detectors

Parallel superconducting strip-line detectors: reset behaviour in the single-strip switch regime

International Nuclear Information System (INIS)

Casaburi, A; Heath, R M; Tanner, M G; Hadfield, R H; Cristiano, R; Ejrnaes, M; Nappi, C

2014-01-01

Superconducting strip-line detectors (SSLDs) are an important emerging technology for the detection of single molecules in time-of-flight mass spectrometry (TOF-MS). We present an experimental investigation of a SSLD laid out in a parallel configuration, designed to address selected single strip-lines operating in the single-strip switch regime. Fast laser pulses were tightly focused onto the device, allowing controllable nucleation of a resistive region at a specific location and study of the subsequent device response dynamics. We observed that in this regime, although the strip-line returns to the superconducting state after triggering, no effective recovery of the bias current occurs, in qualitative agreement with a phenomenological circuit simulation that we performed. Moreover, from theoretical considerations and by looking at the experimental pulse amplitude distribution histogram, we have the first confirmation of the fact that the phenomenological London model governs the current redistribution in these large area devices also after detection events. (paper)

Toxic epidermal necrolysis successfully treated with etanercept.

Science.gov (United States)

Gubinelli, Emanuela; Canzona, Flora; Tonanzi, Tiziano; Raskovic, Desanka; Didona, Biagio

2009-03-01

Toxic epidermal necrolysis (TEN) is a rare and acute severe adverse reaction to drugs, characterised by massive apoptosis and widespread epidermal and mucosal detachment. Although no gold standard therapy exists, human i.v. immunoglobulins have recently been described as an effective treatment for this disease. We report a case of phenobarbital-induced TEN in a 59-year-old white woman where the epidermal detachment stopped 48 h after beginning the etanercept treatment with complete healing after 20 days. To the best of our knowledge, this is only the second reported case of TEN successfully treated with etanercept.

Optimizing the Stripping Procedure for LHCb

CERN Document Server

Richardson, Rachel

2017-01-01

The LHCb experiment faces a major challenge from the large amounts of data received while the LHC is running. The ability to sort this information in a useful manner is important for working groups to perform physics analyses. Both hardware and software triggers are used to decrease the data rate and then the stripping process is used to sort the data into streams and further into stripping lines. This project studies the hundreds of stripping lines to look for overlaps between them in order to make the stripping process more efficient.

Comparison of avian biochemical test results with Abaxis VetScan and Hitachi 911 analyzers.

Science.gov (United States)

Greenacre, Cheryl B; Flatland, Bente; Souza, Marcy J; Fry, Michael M

2008-12-01

To compare results of clinical biochemical analysis using an Abaxis VetScan bench-top analyzer with reagents specifically marketed for avian use and a Hitachi 911 analyzer, plasma (both methods) and whole blood (VetScan method) samples from 20 clinically healthy Hispaniolan Amazon parrots (Amazona ventralis) were analyzed. Correlation between methods was very high (r = 0.9-1.0) for aspartate aminotransferase (AST), calcium, glucose, and uric acid; high (r = 0.7-0.89) for creatine kinase (CK), phosphorus, potassium, and total protein; moderate (r = 0.5-0.69) for globulin; and low (r = 0.3-0.49) for albumin and sodium. VetScan analyzer results for globulin, sodium, and uric acid had a constant negative bias (values below those from the Hitachi method). Based on difference plot analysis, results for AST, calcium, CK, and glucose are comparable. Because 16 of 20 values fell below the lower detection limit of the VetScan analyzer, bile acid data were excluded from analysis. By using a relatively small sample size (0.1 ml whole blood or plasma), the VetScan analyzer offers rapid in-house results, compact size, and ease of operation. For 4 of the most clinically relevant biochemical analytes used in avian medicine (AST, calcium, CK, glucose), it offers reliable values. For an additional 4 analytes (phosphorous, potassium, total protein, uric acid), establishing analyzer-specific reference intervals is recommended. Neither the VetScan nor the Hitachi method is recommended to assess albumin and globulin concentrations.

Using Comic Strips in Language Classes

Science.gov (United States)

Csabay, Noémi

2006-01-01

The author believes that using comic strips in language-learning classes has three main benefits. First, comic strips motivate younger learners. Second, they provide a context and logically connected sentences to help language learning. Third, their visual information is helpful for comprehension. The author argues that comic strips can be used in…

Test-beam evaluation of heavily irradiated silicon strip modules for ATLAS Phase-II Strip Tracker Upgrade

CERN Document Server

Blue, Andrew; The ATLAS collaboration

2018-01-01

The planned HL-LHC (High Luminosity LHC) is being designed to maximise the physics potential of the LHC with 10 years of operation at instantaneous luminosities of 7.5x1034cm−2s−1. A consequence of this increased luminosity is the expected radiation damage requiring the tracking detectors to withstand hadron equivalences to over 1x1015 1 MeV neutron equivalent per cm2 in the ATLAS Strips system. The silicon strip tracker exploits the concept of modularity. Fast readout electronics, deploying 130nm CMOS front-end electronics are glued on top of a silicon sensor to make a module. The radiation hard n-in-p micro-strip sensors used have been developed by the ATLAS ITk Strip Sensor collaboration and produced by Hamamatsu Photonics. A series of tests were performed at the DESY-II and CERN SPS test beam facilities to investigate the detailed performance of a strip module with both 2.5cm and 5cm length strips before and after irradiation with 8x1014neqcm−2 protons and a total ionising dose of 37.2MRad. The DURA...

Pavement Stripping in Saudi Arabia: Prediction and Prevention

Directory of Open Access Journals (Sweden)

H.I. Al-Abdul Wahhab

2004-12-01

Full Text Available Pavement weathering or stripping is a major distress in highway networks in arid regions. Using the Saudi Arabian road network as a case study area, seventeen road test sections were selected, out of which eight were stripped and nine were non-stripped. Aggregates from quarries used to build these sections were also collected and subjected to detailed physical and chemical tests to evaluate the ability of these tests to distinguish between stripped and non-stripped sections. The modified Lottman test was used to distinguish between compacted mixes. In addition, the Swedish Rolling Bottle test, was also found to be effective in being able to distinguish between different asphalt-aggregates for stripping potential. Eleven anti-stripping liquid additives, lime and cement, in addition to two polymers, were evaluated for their ability to reduce/eliminate stripping potential of stripping-prone aggregates. It was found that EE-2 Polymer, Portland cement, and their combination were effective with all aggregate sources.

Spatiotemporal Expression of p63 in Mouse Epidermal Commitment

Directory of Open Access Journals (Sweden)

Qian Zhao

2015-12-01

Full Text Available The embryonic surface ectoderm is a simple flat epithelium consisting of cells that express the cytokeratins K8/K18. Before stratification, K5/K14 expression substitutes K8/K18 expression, marking the event called epidermal commitment. Previous studies show that the transcription factor p63 plays an essential role in epidermal commitment. However, detailed expression information of p63 during early epidermal development in mice is still unclear. We systematically studied the expression pattern of p63 in mouse epidermal commitment, together with K8 and K5. We show that p63 expression could be detected as early as E8.5 in mouse embryos preceding epidermal commitment. p63 expression first appears near the newly formed somites and the posterior part of the embryo, further expanding to the whole embryonic surface with particular enrichment in the first branchial arches and the limb buds. ΔNp63 is the major class of isoforms expressed in this period. Relative expression intensity of p63 depends on the embryonic position. In summary, there is a sequential and regular expression pattern of K8, p63 and K5 in mouse epidermal commitment. Our study not only contributes to understanding the early events during epidermal development but also provides a basal tool to study the function of p63 in mammals.

Tight junction regulates epidermal calcium ion gradient and differentiation

International Nuclear Information System (INIS)

Kurasawa, Masumi; Maeda, Tetsuo; Oba, Ai; Yamamoto, Takuya; Sasaki, Hiroyuki

2011-01-01

Research highlights: → We disrupted epidermal tight junction barrier in reconstructed epidermis. → It altered Ca 2+ distribution and consequentially differentiation state as well. → Tight junction should affect epidermal homeostasis by maintaining Ca 2+ gradient. -- Abstract: It is well known that calcium ions (Ca 2+ ) induce keratinocyte differentiation. Ca 2+ distributes to form a vertical gradient that peaks at the stratum granulosum. It is thought that the stratum corneum (SC) forms the Ca 2+ gradient since it is considered the only permeability barrier in the skin. However, the epidermal tight junction (TJ) in the granulosum has recently been suggested to restrict molecular movement to assist the SC as a secondary barrier. The objective of this study was to clarify the contribution of the TJ to Ca 2+ gradient and epidermal differentiation in reconstructed human epidermis. When the epidermal TJ barrier was disrupted by sodium caprate treatment, Ca 2+ flux increased and the gradient changed in ion-capture cytochemistry images. Alterations of ultrastructures and proliferation/differentiation markers revealed that both hyperproliferation and precocious differentiation occurred regionally in the epidermis. These results suggest that the TJ plays a crucial role in maintaining epidermal homeostasis by controlling the Ca 2+ gradient.

Human corpus luteum: presence of epidermal growth factor receptors and binding characteristics

International Nuclear Information System (INIS)

Ayyagari, R.R.; Khan-Dawood, F.S.

1987-01-01

Epidermal growth factor receptors are present in many reproductive tissues but have not been demonstrated in the human corpus luteum. To determine the presence of epidermal growth factor receptors and its binding characteristics, we carried out studies on the plasma cell membrane fraction of seven human corpora lutea (days 16 to 25) of the menstrual cycle. Specific epidermal growth factor receptors were present in human corpus luteum. Insulin, nerve growth factor, and human chorionic gonadotropin did not competitively displace epidermal growth factor binding. The optimal conditions for corpus luteum-epidermal growth factor receptor binding were found to be incubation for 2 hours at 4 degrees C with 500 micrograms plasma membrane protein and 140 femtomol 125 I-epidermal growth factor per incubate. The number (mean +/- SEM) of epidermal growth factor binding sites was 12.34 +/- 2.99 X 10(-19) mol/micrograms protein; the dissociation constant was 2.26 +/- 0.56 X 10(-9) mol/L; the association constant was 0.59 +/- 0.12 X 10(9) L/mol. In two regressing corpora lutea obtained on days 2 and 3 of the menstrual cycle, there was no detectable specific epidermal growth factor receptor binding activity. Similarly no epidermal growth factor receptor binding activity could be detected in ovarian stromal tissue. Our findings demonstrate that specific receptors for epidermal growth factor are present in the human corpus luteum. The physiologic significance of epidermal growth factor receptors in human corpus luteum is unknown, but epidermal growth factor may be involved in intragonadal regulation of luteal function

Large strip RPCs for the LEPS2 TOF system

Energy Technology Data Exchange (ETDEWEB)

Tomida, N., E-mail: natsuki@scphys.kyoto-u.ac.jp [Department of Physics, Kyoto University, Kyoto 606-8502 (Japan); Niiyama, M. [Department of Physics, Kyoto University, Kyoto 606-8502 (Japan); Ohnishi, H. [RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198 (Japan); Tran, N. [Research Center for Nuclear Physics (RCNP), Osaka University, Ibaraki, Osaka 567-0047 (Japan); Hsieh, C.-Y.; Chu, M.-L.; Chang, W.-C. [Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan (China); Chen, J.-Y. [National Synchrotron Radiation Research Center (NSRRC), Hsinchu 30076, Taiwan (China)

2014-12-01

High time-resolution resistive plate chambers (RPCs) with large-size readout strips are developed for the time-of-flight (TOF) detector system of the LEPS2 experiment at SPring-8. The experimental requirement is a 50-ps time resolution for a strip size larger than 100 cm{sup 2}/channel. We are able to achieve 50-ps time resolutions with 2.5×100 cm{sup 2} strips by directly connecting the amplifiers to strips. With the same time resolution, the number of front-end electronics (FEE) is also reduced by signal addition. - Highlights: • Find a way to achieve a good time resolution with a large strip RPC. • 2.5 cm narrow strips have better resolutions than 5.0 cm ones. • The 0.5 mm narrow strip interval shows flat time resolutions between strips. • FEEs directly connected to strips make the signal reflection at the strip edge small. • A time resolution of 50 ps was achieved with 2.5 cm×100 cm strips.

Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers.

Science.gov (United States)

Salerno, Simona; Morelli, Sabrina; Giordano, Francesca; Gordano, Amalia; Bartolo, Loredana De

2016-10-01

In vitro models of human bioengineered skin substitutes are an alternative to animal experimentation for testing the effects and toxicity of drugs, cosmetics and pollutants. For the first time specific and distinct human epidermal strata were engineered by using membranes and keratinocytes. To this purpose, biodegradable membranes of chitosan (CHT), polycaprolactone (PCL) and a polymeric blend of CHT-PCL were prepared by phase-inversion technique and characterized in order to evaluate their morphological, physico-chemical and mechanical properties. The capability of membranes to modulate keratinocyte differentiation inducing specific interactions in epidermal membrane systems was investigated. The overall results demonstrated that the membrane properties strongly influence the cell morpho-functional behaviour of human keratinocytes, modulating their terminal differentiation, with the creation of specific epidermal strata or a fully proliferative epidermal multilayer system. In particular, human keratinocytes adhered on CHT and CHT-PCL membranes, forming the structure of the epidermal top layers, such as the corneum and granulosum strata, characterized by withdrawal or reduction from the cell cycle and cell proliferation. On the PCL membrane, keratinocytes developed an epidermal basal lamina, with high proliferating cells that stratified and migrated over time to form a complete differentiating epidermal multilayer system. Copyright © 2016 Elsevier B.V. All rights reserved.

Mechanical behaviour of a creased thin strip

Directory of Open Access Journals (Sweden)

J. Liu

2018-02-01

Full Text Available In this study the mechanical behaviour of a creased thin strip under opposite-sense bending was investigated. It was found that a simple crease, which led to the increase of the second moment of area, could significantly alter the overall mechanical behaviour of a thin strip, for example the peak moment could be increased by 100 times. The crease was treated as a cylindrical segment of a small radius. Parametric studies demonstrated that the geometry of the strip could strongly influence its flexural behaviour. We showed that the uniform thickness and the radius of the creased segment had the greatest and the least influence on the mechanical behaviour, respectively. We further revealed that material properties could dramatically affect the overall mechanical behaviour of the creased strip by gradually changing the material from being linear elastic to elastic-perfect plastic. After the formation of the fold, the moment of the two ends of the strip differed considerably when the elasto-plastic materials were used, especially for materials with smaller tangent modulus in the plastic range. The deformation patterns of the thin strips from the finite element simulations were verified by physical models made of thin metal strips. The findings from this study provide useful information for designing origami structures for engineering applications using creased thin strips.

Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats

DEFF Research Database (Denmark)

Olsen, Peter Skov; Boesby, S.; Kirkegaard, P.

2013-01-01

The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal...... growth factor could be identified in portal venous blood after intestinal instillation of epidermal growth factor. Brunner's glands and the submandibular glands secrete epidermal growth factor. Extirpation of Brunner's glands decreased liver regeneration, whereas removal of the submandibular glands had...... no effect on liver regeneration. Epidermal growth factor antiserum reduced liver regeneration significantly. Oral or s.c. administration of epidermal growth factor had no effect on liver regeneration, whereas epidermal growth factor enhanced the effect of insulin and glucagon on liver regeneration...

Epidermal growth factor in alkali-burned corneal epithelial wound healing.

Science.gov (United States)

Singh, G; Foster, C S

1987-06-15

We conducted a double-masked study to evaluate the effect of epidermal growth factor on epithelial wound healing and recurrent erosions in alkali-burned rabbit corneas. Epithelial wounds 10 mm in diameter healed completely under the influence of topical epidermal growth factor, whereas the control corneas did not resurface in the center. On reversal of treatment, the previously nonhealing epithelial defects healed when treated with topical epidermal growth factor eyedrops. Conversely, the epidermal growth factor-treated and resurfaced corneas developed epithelial defects when treatment was discontinued. Histopathologic examination disclosed hyperplastic epithelium growing over the damaged stroma laden with polymorphonuclear leukocytes when treated with epidermal growth factor eyedrops, but it did not adhere to the underlying tissue. Hydropic changes were seen intracellularly as well as between the epithelial cells and the stroma.

Epidermal and dermal integumentary structures of ankylosaurian dinosaurs.

Science.gov (United States)

Arbour, Victoria M; Burns, Michael E; Bell, Phil R; Currie, Philip J

2014-01-01

Ankylosaurian dinosaurs are most notable for their abundant and morphologically diverse osteoderms, which would have given them a spiky appearance in life. Isolated osteoderms are relatively common and provide important information about the structure of the ankylosaur dermis, but fossilized impressions of the soft-tissue epidermis of ankylosaurs are rare. Nevertheless, well-preserved integument exists on several ankylosaur fossils that shows osteoderms were covered by a single epidermal scale, but one or many millimeter-sized ossicles may be present under polygonal, basement epidermal scales. Evidence for the taxonomic utility of ankylosaurid epidermal scale architecture is presented for the first time. This study builds on previous osteological work that argues for a greater diversity of ankylosaurids in the Dinosaur Park Formation of Alberta than has been traditionally recognized and adds to the hypothesis that epidermal skin impressions are taxonomically relevant across diverse dinosaur clades. Copyright © 2013 Wiley Periodicals, Inc.

Comparative limnology of strip-mine lakes

Energy Technology Data Exchange (ETDEWEB)

Parsons, J D

1964-01-01

Lakes were classified according to chemical properties. The concentration of the ferric iron oxides was responsible for a reddish-black turbidity which, in turn, played a major role in the thermal stratification of red strip-mine lakes. Owing to the lack of measurable turbidity and as a result of selective absorption of visible solar radiation, other strip-mine lakes appeared blue in color. The annual heat budget and the summer heat budget are essentially equivalent under saline conditions. Regardless of the physical and chemical conditions of the strip-mine lakes, heat income was a function of the circulating water mass. The progressive oxidation and precipitation of the iron oxides is the key to the classification of strip-mine lakes.

A synthetic C16 omega-hydroxyphytoceramide improves skin barrier functions from diversely perturbed epidermal conditions.

Science.gov (United States)

Oh, Myoung Jin; Nam, Jin Ju; Lee, Eun Ok; Kim, Jin Wook; Park, Chang Seo

2016-10-01

Omega-hydroxyceramides (ω-OH-Cer) play a crucial role in maintaining the integrity of skin barrier. ω-OH-Cer are the primary lipid constituents of the corneocyte lipid envelope (CLE) covalently attached to the outer surface of the cornified envelope linked to involucrin to become bound form lipids in stratum corneum (SC). CLE becomes a hydrophobic impermeable layer of matured corneocyte preventing loss of natural moisturizing factor inside the corneocytes. More importantly, CLE may also play an important role in the formation of proper orientation of intercellular lipid lamellar structure by interdigitating with the intercellular lipids in a comb-like fashion. Abnormal barrier conditions associated with atopic dermatitis but also UVB-irradiated skins are known to have lowered level of bound lipids, especially ω-OH-Cer, which indicate that ω-OH-Cer play an important role in maintaining the integrity of skin barrier. In this study, protective effects of a novel synthetic C16 omega-hydroxyphytoceramides (ω-OH-phytoceramide) on skin barrier function were investigated. Epidermal barrier disruption was induced by UVB irradiation, tape-stripping in hairless mouse and human skin. Protective effect of damaged epidermis was evaluated using the measurement of transepidermal water loss and cohesion of SC. Increased keratinocyte differentiation was verified using cultured keratinocyte through western blot. Results clearly demonstrated that a synthetic C16 ω-OH-phytoceramide enhanced the integrity of SC and accelerated the recovery of damaged skin barrier function by stimulating differentiation process. In a conclusion, a synthetic C16 ω-OH-phytoceramide treatment improved epidermal homeostasis in several disrupted conditions.

Epidermal growth factor in the rat prostate

DEFF Research Database (Denmark)

Tørring, Niels; Jørgensen, P E; Poulsen, Steen Seier

1998-01-01

Epidermal growth factor (EGF) induces proliferation in prostate epithelial and stromal cells in primary culture. This investigation was set up to characterize the time and spatial expression of EGF in the rat prostate.......Epidermal growth factor (EGF) induces proliferation in prostate epithelial and stromal cells in primary culture. This investigation was set up to characterize the time and spatial expression of EGF in the rat prostate....

Superconducting nano-strip particle detectors

International Nuclear Information System (INIS)

Cristiano, R; Ejrnaes, M; Casaburi, A; Zen, N; Ohkubo, M

2015-01-01

We review progress in the development and applications of superconducting nano-strip particle detectors. Particle detectors based on superconducting nano-strips stem from the parent devices developed for single photon detection (SSPD) and share with them ultra-fast response times (sub-nanosecond) and the ability to operate at a relatively high temperature (2–5 K) compared with other cryogenic detectors. SSPDs have been used in the detection of electrons, neutral and charged ions, and biological macromolecules; nevertheless, the development of superconducting nano-strip particle detectors has mainly been driven by their use in time-of-flight mass spectrometers (TOF-MSs) where the goal of 100% efficiency at large mass values can be achieved. Special emphasis will be given to this case, reporting on the great progress which has been achieved and which permits us to overcome the limitations of existing mass spectrometers represented by low detection efficiency at large masses and charge/mass ambiguity. Furthermore, such progress could represent a breakthrough in the field. In this review article we will introduce the device concept and detection principle, stressing the peculiarities of the nano-strip particle detector as well as its similarities with photon detectors. The development of parallel strip configuration is introduced and extensively discussed, since it has contributed to the significant progress of TOF-MS applications. (paper)

Genetic analysis of Ras genes in epidermal development and tumorigenesis

Science.gov (United States)

Drosten, Matthias; Lechuga, Carmen G; Barbacid, Mariano

2013-01-01

Proliferation and differentiation of epidermal keratinocytes are tightly controlled to ensure proper development and homeostasis of the epidermis. The Ras family of small GTPases has emerged as a central node in the coordination of cell proliferation in the epidermis. Recent genetic evidence from mouse models has revealed that the intensity of Ras signaling modulates the proliferative capacity of epidermal keratinocytes. Interfering with Ras signaling either by combined elimination of the 3 Ras genes from the basal layer of the epidermis or by overexpression of dominant-negative Ras isoforms caused epidermal thinning due to hypoproliferation of keratinocytes. In contrast, overexpression of oncogenic Ras mutants in different epidermal cell layers led to hyperproliferative phenotypes including the development of papillomas and squamous cell carcinomas. Here, we discuss the value of loss- and gain-of-function studies in mouse models to assess the role of Ras signaling in the control of epidermal proliferation. PMID:24150175

Reptured Epidermal Inclusion Cyst in the Axilla: A Case Report

International Nuclear Information System (INIS)

Kim, Kyu Soon; Kim, Hak Hee; Shin, Hee Jeong; Yang, Hye Rin; Sohn, Jeong Hee; Kwon, Gui Young; Gong, Gyung Yub

2006-01-01

Epidermal inclusion cysts, the most common type of simple epithelial cyst, are typically well-encapsulated, subepidermal and mobile nodules. They may occur anywhere, but are mostly found on the scalp, face, neck, trunk, and back. Less than 10% of epidermal inclusion cysts occur on the extremities, and even fewer are found on the palms, soles, and breasts. If epidermal inclusion cysts rupture, foreign body reaction, granulomatous reaction or abscess formation could follow. We described here the sonographic findings of ruptured epidermal inclusion cyst of the right axilla in a 33-year-old woman who presented with a palpable axillary mass forming an inflammatory abscess

Depletive stripping chronopotentiometry : a major step forward in electrochemical stripping techniques for metal ion speciation analysis

NARCIS (Netherlands)

Town, R.M.; Leeuwen, van H.P.

2004-01-01

A comparative evaluation of the utility of the various modes of stripping chronopotentiometry (SCP) for trace metal speciation analysis is presented in the broad context of stripping voltammetric techniques. The remarkable fundamental advantages of depletive SCP at scanned deposition potential

Ductility of reinforced concrete columns confined with stapled strips

International Nuclear Information System (INIS)

Tahir, M.F.; Khan, Q.U.Z.; Shabbir, F.; Sharif, M.B.; Ijaz, N.

2015-01-01

Response of three 150x150x450mm short reinforced concrete (RC) columns confined with different types of confining steel was investigated. Standard stirrups, strips and stapled strips, each having same cross-sectional area, were employed as confining steel around four comer column bars. Experimental work was aimed at probing into the affect of stapled strip confinement on post elastic behavior and ductility level under cyclic axial load. Ductility ratios, strength enhancement factor and core concrete strengths were compared to study the affect of confinement. Results indicate that strength enhancement in RC columns due to strip and stapled strip confinement was not remarkable as compared to stirrup confined column. It was found that as compared to stirrup confined column, stapled strip confinement enhanced the ductility of RC column by 183% and observed axial capacity of stapled strip confined columns was 41 % higher than the strip confined columns. (author)

Potential profile in a conducting polymer strip

DEFF Research Database (Denmark)

Bay, Lasse; West, Keld; Vlachopoulos, Nikolaos

2002-01-01

Many conjugated polymers show an appreciable difference in volume between their oxidized and reduced forms. This property can be utilized in soft electrochemically driven actuators, "artificial muscles". Several geometries have been proposed for the conversion of the volume expansion into useful...... mechanical work. In a particularly simple geometry, the length change of polymer strips is exploited. The polymer strips are connected to the driving circuit at the end of the strip that is attached to the support of the device. The other end of the strip is connected to the load. The advantage of this set...

Study on lifetime of C stripping foils

International Nuclear Information System (INIS)

Zhang Hongbin; Lu Ziwei; Zhao Yongtao; Li Zhankui; Xu Hushan; Xiao Guoqing; Wang Yuyu; Zhang Ling; Li Longcai; Fang Yan

2007-01-01

The carbon stripping foils can be prepared with the AC and DC arc discharge methods, or even sandwiched with AC-DC alternative layers. The lifetime of the carbon stripping foils of 19 μg/cm 2 prepared with different methods and/or structures was measured. The factors affecting the bombarding lifetime of the carbon stripping foils, especially the method of the foil preparation and the structure of the carbon stripping foils, were discussed. It is observed that the foils prepared with the DC arc discharge method have a longer bombarding lifetime than those prepared with the AC arc discharge method. (authors)

Immune sensitization against epidermal antigens in polymorphous light eruption

International Nuclear Information System (INIS)

Gonzalez-Amaro, R.; Baranda, L.; Salazar-Gonzalez, J.F.; Abud-Mendoza, C.; Moncada, B.

1991-01-01

To get further insight into the pathogenesis of polymorphous light eruption, we studied nine patients with polymorphous light eruption and six healthy persons. Two skin biopsy specimens were obtained from each person, one from previously ultraviolet light-irradiated skin and another one from unirradiated skin. An epidermal cell suspension, skin homogenate, or both were prepared from each specimen. Autologous cultures were made with peripheral blood mononuclear cells combined with irradiated or unirradiated skin homogenate and peripheral blood mononuclear cells combined with irradiated or unirradiated epidermal cell suspension. Cell proliferation was assessed by 3H-thymidine incorporation assay. The response of peripheral blood mononuclear cells to unirradiated epidermal cells or unirradiated skin homogenate was similar in both patients and controls. However, peripheral blood mononuclear cells from patients with polymorphous light eruption showed a significantly increased proliferative response to both irradiated epidermal cells and irradiated skin homogenate. Our results indicate that ultraviolet light increases the stimulatory capability of polymorphous light eruption epidermal cells in a unidirectional mixed culture with autologous peripheral blood mononuclear cells. This suggests that an immune sensitization against autologous ultraviolet light-modified skin antigens occurs in polymorphous light eruption

Post-female-circumcision clitoral epidermal inclusion cyst: a case ...

African Journals Online (AJOL)

Keywords: complication, epidermal inclusion cyst, female circumcision. Pediatric Urology Division, Department of Urology, ... transplantation of the epidermis into the subcutaneous tissue with subsequent proliferation of epidermal ... The evolution of the practice of FGM, from being performed by traditional birth attendants to.

Ultrasonic examination of JBK-75 strip material

International Nuclear Information System (INIS)

Cook, K.V.; Cunningham, R.A. Jr.; Lewis, J.C.; McClung, R.W.

1982-12-01

An ultrasonic inspection system was assembled to inspect the JBK-75 stainless steel sheath material (for the Large Coil Project) for the Westinghouse-Airco superconducting magnet program. The mechanical system provided for handling the 180-kg (400-lb) coils of strip material [1.6 mm thick by 78 mm wide by 90 to 120 m long (0.064 by 3.07 in. by 300 to 400 ft)], feeding the strip through the ultrasonic inspection and cleaning stations, and respooling the coils. We inspected 54 coils of strip for both longitudinal and laminar flaws. Simulated flaws were used to calibrate both inspections. Saw-cut notches [0.28 mm deep (0.011 in., about 17% of the strip thickness)] were used to calibrate the longitudinal flaw inspections; 1.59-mm-diam (0.063-in.) flat-bottom holes drilled halfway through a calibration strip were used to calibrate the laminar flaw tests

Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.

Science.gov (United States)

Zhang, Mingdi; Cai, Shizhong; Zuo, Bin; Gong, Wei; Tang, Zhaohui; Zhou, Di; Weng, Mingzhe; Qin, Yiyu; Wang, Shouhua; Liu, Jun; Ma, Fei; Quan, Zhiwei

2017-05-01

Gallbladder cancer has poor prognosis and limited therapeutic options. Arctigenin, a representative dibenzylbutyrolactone lignan, occurs in a variety of plants. However, the molecular mechanisms involved in the antitumor effect of arctigenin on gallbladder cancer have not been fully elucidated. The expression levels of epidermal growth factor receptor were examined in 100 matched pairs of gallbladder cancer tissues. A positive correlation between high epidermal growth factor receptor expression levels and poor prognosis was observed in gallbladder cancer tissues. Pharmacological inhibition or inhibition via RNA interference of epidermal growth factor receptor induced cellular senescence in gallbladder cancer cells. The antitumor effect of arctigenin on gallbladder cancer cells was primarily achieved by inducing cellular senescence. In gallbladder cancer cells treated with arctigenin, the expression level of epidermal growth factor receptor significantly decreased. The analysis of the activity of the kinases downstream of epidermal growth factor receptor revealed that the RAF-MEK-ERK signaling pathway was significantly inhibited. Furthermore, the cellular senescence induced by arctigenin could be reverted by pcDNA-epidermal growth factor receptor. Arctigenin also potently inhibited the growth of tumor xenografts, which was accompanied by the downregulation of epidermal growth factor receptor and induction of senescence. This study demonstrates arctigenin could induce cellular senescence in gallbladder cancer through the modulation of epidermal growth factor receptor pathway. These data identify epidermal growth factor receptor as a key regulator in arctigenin-induced gallbladder cancer senescence.

Hardness of approximation for strip packing

DEFF Research Database (Denmark)

Adamaszek, Anna Maria; Kociumaka, Tomasz; Pilipczuk, Marcin

2017-01-01

Strip packing is a classical packing problem, where the goal is to pack a set of rectangular objects into a strip of a given width, while minimizing the total height of the packing. The problem has multiple applications, for example, in scheduling and stock-cutting, and has been studied extensively......)-approximation by two independent research groups [FSTTCS 2016,WALCOM 2017]. This raises a questionwhether strip packing with polynomially bounded input data admits a quasi-polynomial time approximation scheme, as is the case for related twodimensional packing problems like maximum independent set of rectangles or two...

"Cut-and-paste" manufacture of multiparametric epidermal electronic systems

Science.gov (United States)

Lu, Nanshu; Yang, Shixuan; Wang, Pulin

2016-05-01

Epidermal electronics is a class of noninvasive and unobstructive skin-mounted, tattoo-like sensors and electronics capable of vital sign monitoring and establishing human-machine interface. The high cost of manpower, materials, vacuum equipment, and photolithographic facilities associated with its manufacture greatly hinders the widespread use of disposable epidermal electronics. Here we report a cost and time effective, completely dry, benchtop "cut-and-paste" method for the freeform and portable manufacture of multiparametric epidermal sensor systems (ESS) within minutes. This versatile method works for all types of thin metal and polymeric sheets and is compatible with any tattoo adhesives or medical tapes. The resulting ESS are multimaterial and multifunctional and have been demonstrated to noninvasively but accurately measure electrophysiological signals, skin temperature, skin hydration, as well as respiratory rate. In addition, planar stretchable coils exploiting double-stranded serpentine design have been successfully applied as wireless, passive epidermal strain sensors.

Caracterização anatômica, química e antibacteriana de folhas de Brunfelsia uniflora (manacá presentes na Mata Atlântica

Directory of Open Access Journals (Sweden)

Maria Bernadete Gonçalves Martins

Full Text Available Brunfelsia uniflora é uma espécie pertencente à família Solanaceae conhecida popularmente como manacá e empregada em medicina popular, suas folhas são empregadas contra artrite, reumatismo, sífilis, picadas de cobra, febre amarela, e ainda como diurética e antitérmica. Objetivou-se realizar um estudo anatômico foliar, através de microscopia de luz e de eletrônica de varredura, bem como análises químicas do extrato foliar através de cromatografia e testes microbiológicos com os extratos foliares para atividade antibacteriana frente a Escherichia coli e Staphylococcus aureus. O material biológico foi coletado em área de Mata Atlântica, nas proximidades da cidade de São Vicente - SP. O estudo da anatomia foliar de Brunfelsia uniflora, evidenciou parênquima paliçádico com duas camadas celulares e o parênquima lacunoso com seis camadas de células; foi observada grande quantidade de drusas no parênquima clorofiliano e predominância de esclerênquima na região da nervura central da folha. A epiderme abaxial apresentou grande quantidade de estômatos, sendo estes quase que ausentes na epiderme adaxial. Estudos através de microscopia eletrônica de varredura permitiram evidenciar uma camada de cera epicuticular ornamental bem característica na epiderme adaxial da folha, predominância de estômatos paracíticos, presença de tricomas capitados e muitos tricomas peltados na epiderme abaxial da folha. A análise química evidenciou alguns picos nos cromatogramas que correspondem a grupos de substâncias que não puderam ser analisadas de forma qualitativa, mas que se pode inferir a ocorrência de derivados de ácido cafeico. Os testes microbiológicos obtidos apresentaram resultados negativos no controle das espécies de bactérias testadas, nas concentrações utilizadas.

Morfologia e anatomia foliar de Bauhinia curvulha Benth. (Leguminosae-Caesalpinioideae Morphology and anatomy of Bauhinia curvula Benth. (Leguminosae-Caesalpinoideae

Directory of Open Access Journals (Sweden)

Maria Helena Rezende

1994-07-01

Full Text Available Foi realizado o estudo morfológico e anatômico da folha de Bauhinia cumula Benth., espécie de cerrado. As observações foram feitas em folhas adultas, tratadas segundo a metodologia usual utilizada em anatomia vegetal. Foi observado que a espécie apresenta as seguintes características: folhas bilobadas cuja incisão foliar chega próximo à região motora; um par de estipulas membranáceas; um par de nectários extraflorais, localizadaos na base do pulvino proximal; a venação possui padrão acródomo; o pecíolo, que possui dois pulvinos, um proximal e um distai, apresenta epiderme contendo grande quantidade de tricomas tecto res simples e glândulas; a lâmina foliar é anfiestomática com predomínio de estômatos dos tipos anomocítico e paracítico; a epiderme adaxial é monoestratificada, subpapilosa, desprovida de tricomas tectores simples e glândulas; a epiderme abaxial é subpapilosa, apresentando numerosos tricomas tectores simples e glândulas; e o mesofilo é formado predominantemente por parênquima paliçádico.A morphological and anatomical study of Bauhinia curvula Benth. leaf, a cerrado spe-cies, was perfomed. The observations, in grown up leaves, prepared according to the costumary methodology used in plant anatomy, showed the following characteristics of the species: bilobed leaves with foliar incision close to the motor region; one pair of membranaceous stipules; one pair of extrafloral nectaries located on the basis of the proximal pulvinus; acrodromous patterns of leaf venetion; the petiole, which has two pulvinus, one proximal and one distal, has an epidermis containing large quantities of simple tector trichomes and glands; the leaf blade, amphiestomatic, with predominance of anomocytic and paracytic stomata; the adaxial epidermis uniserial, sub papillose, without tector trichomes and glands; the abaxial epiderms, sub-papillose, presents a high number of simple trichomes and glands; and the mesophyll with a basic

Transfusion and blood donation in comic strips.

Science.gov (United States)

Lefrère, Jean-Jacques; Danic, Bruno

2013-07-01

The representation of blood transfusion and donation of blood in the comic strip has never been studied. The comic strip, which is a relatively recent art, emerged in the 19th century before becoming a mass medium during the 20th century. We have sought, by calling on collectors and using the resources of Internet, comic strips devoted, wholly or in part, to the themes of transfusion and blood donation. We present some of them here in chronologic order, indicating the title, country of origin, year of publication, and names of authors. The theme of the superhero using transfusion to transmit his virtues or his powers is repeated throughout the 20th century in North American comic strips. More recently, comic strips have been conceived from the outset with a promotional aim. They perpetuate positive images and are directed toward a young readership, wielding humor to reduce the fear of venipuncture. Few comic strips denounce the abuse of the commercialization of products derived from the human body. The image of transfusion and blood donation given by the comic strips is not to be underestimated because their readership is primarily children, some of whom will become blood donors. Furthermore, if some readers are transfused during their lives, the impact of a memory more or less conscious of these childhood readings may resurface, both in hopes and in fears. Copyright © 2013 Elsevier Inc. All rights reserved.

Estudo anátomo-morfológico de dicotiledôneas das dunas de Salvador - Bahia: Borreria cymosa Cham. et Schl. e Chiococca brachiata R. et P. (Rubiaceae Morpho-anatomic studies of dicotiledons from Salvador - Bahia dunes: Borreria cymosa Chamo et Schl. and Chiococca brachiata R. et P. (Rubiaceae

Directory of Open Access Journals (Sweden)

Elzeni Diladelfo de Gusmão

1992-07-01

Full Text Available Prosseguindo as pesquisas sobre a vegetação das Dunas do Abaeté, Salvador, Bahia, apresentam-se as Rubiaceae: Borreria cymosa e Chiococca brachiata. Cortes histológicos à mão livre, com lâminas de barbear, seguindo-se as técnicas de rotina. Estudaram-se as epidermes, mesofilo, nervura central, bordo e pecíolo. Contaram-se os estômatos por área foliar. Folhas dorsiventrais e hipoestomáticas, glabras, cutícula adaxial espessa e brilhante. Numerosas gotas lipídicas, esclereídeos no córtex do pecíolo e nervura central. Borreria: tem epiderme abaxial com paredes fortemente sinuosas e estrias epicuticulares; células incolores, subjacentes à epiderme adaxial; mesofilo com drusas e ráfides de oxolato de cálcio, bainhas de células volumosas envolvendo todos os feixes. Chiococca: epiderme de paredes curvas, cutícula formando "flanges" ao nível da nervura mediana, bordo e pecíolo. Pequenas células cheias de cloroplastos envolvem feixes menores. Clorênquima denso. Conclui-se que as plantas apresentam caracteres de adaptação ao meio xérico. As características anatômicas tanto quanto ao morfológicas individualizam os taxons.Following studies of the vegetation from the dunes of Abaeté, Salvador, Bahia, the Rubiaceae Borreria cymosa and Chiococca brachiata are described. Free hand histological were made with razor blades, following routine procedures. The epidermis, mesophyll, central nerve, margin and petiole were studied. Stomata per area of leaf were counted. Dorsiventral and hypoestomatic leaves, glabrous, adaxial cuticle heavy anda brillant. Numerous lipid droplets, sclereids in cortex of petiole and central nerve. Borreria: has abaxial epidermis with strongly sinuos walls and striated; cells colorless, subjacent to adaxial epidermis; mesophyll with druses and raphides of calcium oxalate, sheaths of volumous cells wrapping all the bundles. Chiococca: epiderm with curved walls, cuticle forming "flanges" at the level of the

Foliar Epidermal Studies of Plants in Euphorbiaceae

Directory of Open Access Journals (Sweden)

H. A. Thakur

2014-03-01

Full Text Available This paper describes foliar epidermal structure in 17 species belonging to 17 genera of the family Euphoprbiaceae. Anomocytic stomata is predominant, rarely they are anisocytic, paracytic on the same foliar surface with different combinations. Leaves are hypostomatic and rarely amphistomatic. The foliar surface is smooth, rarely striated. The foliar epidermal cell walls are straight or undulate. Distribution of stomata, stomatal index, stomatal frequency, stomatal size and other cell wall contours are described in detail.

Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate.

Science.gov (United States)

Chermnykh, Elina; Kalabusheva, Ekaterina; Vorotelyak, Ekaterina

2018-03-27

Epidermal stem cells reside within the specific anatomic location, called niche, which is a microenvironment that interacts with stem cells to regulate their fate. Regulation of many important processes, including maintenance of stem cell quiescence, self-renewal, and homeostasis, as well as the regulation of division and differentiation, are common functions of the stem cell niche. As it was shown in multiple studies, extracellular matrix (ECM) contributes a lot to stem cell niches in various tissues, including that of skin. In epidermis, ECM is represented, primarily, by a highly specialized ECM structure, basement membrane (BM), which separates the epidermal and dermal compartments. Epidermal stem cells contact with BM, but when they lose the contact and migrate to the overlying layers, they undergo terminal differentiation. When considering all of these factors, ECM is of fundamental importance in regulating epidermal stem cells maintenance, proper mobilization, and differentiation. Here, we summarize the remarkable progress that has recently been made in the research of ECM role in regulating epidermal stem cell fate, paying special attention to the hair follicle stem cell niche. We show that the destruction of ECM components impairs epidermal stem cell morphogenesis and homeostasis. A deep understanding of ECM molecular structure as well as the development of in vitro system for stem cell maintaining by ECM proteins may bring us to developing new approaches for regenerative medicine.

Development of floating strip micromegas detectors

Energy Technology Data Exchange (ETDEWEB)

Bortfeldt, Jonathan

2014-04-28

Micromegas are high-rate capable, high-resolution micro-pattern gaseous detectors. Square meter sized resistive strip Micromegas are foreseen as replacement of the currently used precision tracking detectors in the Small Wheel, which is part of the forward region of the ATLAS muon spectrometer. The replacement is necessary to ensure tracking and triggering performance of the muon spectrometer after the luminosity increase of the Large Hadron Collider beyond its design value of 10{sup 34} cm{sup -2}s{sup -1} around 2020. In this thesis a novel discharge tolerant floating strip Micromegas detector is presented and described. By individually powering copper anode strips, the effects of a discharge are confined to a small region of the detector. This reduces the impact of discharges on the efficiency by three orders of magnitude, compared to a standard Micromegas. The physics of the detector is studied and discussed in detail. Several detectors are developed: A 6.4 x 6.4 cm{sup 2} floating strip Micromegas with exchangeable SMD capacitors and resistors allows for an optimization of the floating strip principle. The discharge behavior is investigated on this device in depth. The microscopic structure of discharges is quantitatively explained by a detailed detector simulation. A 48 x 50 cm{sup 2} floating strip Micromegas is studied in high energy pion beams. Its homogeneity with respect to pulse height, efficiency and spatial resolution is investigated. The good performance in high-rate background environments is demonstrated in cosmic muon tracking measurements with a 6.4 x 6.4 cm{sup 2} floating strip Micromegas under lateral irradiation with 550 kHz 20 MeV proton beams. A floating strip Micromegas doublet with low material budget is developed for ion tracking without limitations from multiple scattering in imaging applications during medical ion therapy. Highly efficient tracking of 20 MeV protons at particle rates of 550 kHz is possible. The reconstruction of the

Development of floating strip micromegas detectors

International Nuclear Information System (INIS)

Bortfeldt, Jonathan

2014-01-01

Micromegas are high-rate capable, high-resolution micro-pattern gaseous detectors. Square meter sized resistive strip Micromegas are foreseen as replacement of the currently used precision tracking detectors in the Small Wheel, which is part of the forward region of the ATLAS muon spectrometer. The replacement is necessary to ensure tracking and triggering performance of the muon spectrometer after the luminosity increase of the Large Hadron Collider beyond its design value of 10 34 cm -2 s -1 around 2020. In this thesis a novel discharge tolerant floating strip Micromegas detector is presented and described. By individually powering copper anode strips, the effects of a discharge are confined to a small region of the detector. This reduces the impact of discharges on the efficiency by three orders of magnitude, compared to a standard Micromegas. The physics of the detector is studied and discussed in detail. Several detectors are developed: A 6.4 x 6.4 cm 2 floating strip Micromegas with exchangeable SMD capacitors and resistors allows for an optimization of the floating strip principle. The discharge behavior is investigated on this device in depth. The microscopic structure of discharges is quantitatively explained by a detailed detector simulation. A 48 x 50 cm 2 floating strip Micromegas is studied in high energy pion beams. Its homogeneity with respect to pulse height, efficiency and spatial resolution is investigated. The good performance in high-rate background environments is demonstrated in cosmic muon tracking measurements with a 6.4 x 6.4 cm 2 floating strip Micromegas under lateral irradiation with 550 kHz 20 MeV proton beams. A floating strip Micromegas doublet with low material budget is developed for ion tracking without limitations from multiple scattering in imaging applications during medical ion therapy. Highly efficient tracking of 20 MeV protons at particle rates of 550 kHz is possible. The reconstruction of the track inclination in a single

7 CFR 29.6128 - Straight Stripped (X Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Straight Stripped (X Group). 29.6128 Section 29.6128... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6128 Straight Stripped (X Group). This group consists of..., and tolerances X1 Fine Quality Straight Stripped. Heavy, ripe, firm, semielastic, normal strength and...

Genetic Variation and Divergence of Genes Involved in Leaf Adaxial-abaxial Polarity Establishment in Brassica rapa

Directory of Open Access Journals (Sweden)

Jianli eLiang

2016-02-01

Full Text Available Alterations in leaf adaxial–abaxial (ad-ab polarity are one of the main factors that are responsible for leaf curvature. In Chinese cabbage, to form a leafy head, leaf incurvature is an essential prerequisite. Identifying ad-ab patterning genes and investigating its genetic variations will facilitate in elucidating the mechanism underlying leaf incurvature during head formation. In the present study we conducted comparative genomic analysis of the identification of 45 leaf ad-ab patterning genes in Brassica rapa based on 26 homologs in Arabidopsis thaliana, indicating that these genes underwent expansion and were retained after whole genome triplication (WGT. We also assessed the nucleotide diversity and selection footprints of these 45 genes in a collection of 94 Brassica rapa accessions that were composed of heading and non-heading morphotypes. Six of the 45 genes showed significant negative Tajima’s D indices and nucleotide diversity reduction in heading accessions compared to that in non-heading accessions, indicating that these underwent purifying selection. Further testing of the BrARF3.1 gene, which was one of the selection signals from a larger collection, confirmed that purifying selection did occur. Our results provide genetic evidence that ad-ab patterning genes are involved in leaf incurvature that is associated in the formation of a leafy head, as well as promote an understanding of the genetic mechanism underlying leafy head formation in Chinese cabbage.

Apparatus for measuring profile thickness of strip material

International Nuclear Information System (INIS)

Hold, A.C.

1982-01-01

Apparatus for measuring the thickness profile of steel strip comprises a radiation source reciprocally movable in a stepwise fashion (by a belt) across the strip width on one side thereof and a single elongated detector on the other side of the strip aligned with the scanning source. This detector may be a fluorescent scintillator detector or an ionisation chamber. Means are provided for sensing the degree of excitation in the detector in synchronism with the scanning source whereby to provide an output representative of the thickness profile of the strip. (author)

Stability of barotropic vortex strip on a rotating sphere.

Science.gov (United States)

Sohn, Sung-Ik; Sakajo, Takashi; Kim, Sun-Chul

2018-02-01

We study the stability of a barotropic vortex strip on a rotating sphere, as a simple model of jet streams. The flow is approximated by a piecewise-continuous vorticity distribution by zonal bands of uniform vorticity. The linear stability analysis shows that the vortex strip becomes stable as the strip widens or the rotation speed increases. When the vorticity constants in the upper and the lower regions of the vortex strip have the same positive value, the inner flow region of the vortex strip becomes the most unstable. However, when the upper and the lower vorticity constants in the polar regions have different signs, a complex pattern of instability is found, depending on the wavenumber of perturbations, and interestingly, a boundary far away from the vortex strip can be unstable. We also compute the nonlinear evolution of the vortex strip on the rotating sphere and compare with the linear stability analysis. When the width of the vortex strip is small, we observe a good agreement in the growth rate of perturbation at an early time, and the eigenvector corresponding to the unstable eigenvalue coincides with the most unstable part of the flow. We demonstrate that a large structure of rolling-up vortex cores appears in the vortex strip after a long-time evolution. Furthermore, the geophysical relevance of the model to jet streams of Jupiter, Saturn and Earth is examined.

Stability of barotropic vortex strip on a rotating sphere

Science.gov (United States)

Sohn, Sung-Ik; Sakajo, Takashi; Kim, Sun-Chul

2018-02-01

We study the stability of a barotropic vortex strip on a rotating sphere, as a simple model of jet streams. The flow is approximated by a piecewise-continuous vorticity distribution by zonal bands of uniform vorticity. The linear stability analysis shows that the vortex strip becomes stable as the strip widens or the rotation speed increases. When the vorticity constants in the upper and the lower regions of the vortex strip have the same positive value, the inner flow region of the vortex strip becomes the most unstable. However, when the upper and the lower vorticity constants in the polar regions have different signs, a complex pattern of instability is found, depending on the wavenumber of perturbations, and interestingly, a boundary far away from the vortex strip can be unstable. We also compute the nonlinear evolution of the vortex strip on the rotating sphere and compare with the linear stability analysis. When the width of the vortex strip is small, we observe a good agreement in the growth rate of perturbation at an early time, and the eigenvector corresponding to the unstable eigenvalue coincides with the most unstable part of the flow. We demonstrate that a large structure of rolling-up vortex cores appears in the vortex strip after a long-time evolution. Furthermore, the geophysical relevance of the model to jet streams of Jupiter, Saturn and Earth is examined.

The organization of human epidermis: functional epidermal units and phi proportionality.

Science.gov (United States)

Hoath, Steven B; Leahy, D G

2003-12-01

The concept that mammalian epidermis is structurally organized into functional epidermal units has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetics, melanocyte:keratinocyte ratios (1:36), and, more recently, Langerhans cell: epidermal cell ratios (1:53). This article examines the concept of functional epidermal units in human skin in which the maintenance of phi (1.618034) proportionality provides a central organizing principle. The following empirical measurements were used: 75,346 nucleated epidermal cells per mm2, 1394 Langerhans cells per mm2, 1999 melanocytes per mm2, 16 (SC) layers, 900-microm2 corneocyte surface area, 17,778 corneocytes per mm2, 14-d (SC) turnover time, and 93,124 per mm2 total epidermal cells. Given these empirical data: (1) the number of corneocytes is a mean proportional between the sum of the Langerhans cell + melanocyte populations and the number of epidermal cells, 3393/17,778-17,778/93,124; (2) the ratio of nucleated epidermal cells over corneocytes is phi proportional, 75,346/17,778 approximately phi3; (3) assuming similar 14-d turnover times for the (SC) and Malpighian epidermis, the number of corneocytes results from subtraction of a cellular fraction equal to approximately 2/phi2 x the number of living cells, 75,436 - (2/phi2 x 75,346) approximately 17,778; and (4) if total epidermal turnover time equals (SC) turnover time x the ratio of living/dead cells, then compartmental turnover times are unequal (14 d for (SC) to 45.3 d for nucleated epidermis approximately 1/2phi) and cellular replacement rates are 52.9 corneocytes/69.3 keratinocytes per mm2 per h approximately 2/phi2. These empirically derived equivalences provide logicomathematical support for the presence of functional epidermal units in human skin. Validation of a phi proportional unit architecture in human epidermis will be important for tissue engineering of skin and the design of instruments for skin measurement.

Estudo das folhas e caule de Hyptidendron canum(Pohl ex Benth. Harley, Lamiaceae

Directory of Open Access Journals (Sweden)

Tatiana S. Fiuza

Full Text Available Hyptidendron canum (Pohl ex Benth. Harley, Lamiaceae, é utilizada popularmente como antimalárica, antiinflamatória, antiulcerativa, anti-hepatotóxica e anticancerígena. O objetivo deste trabalho foi realizar o estudo morfo-anatômico das folhas e caules e identificar as principais classes de metabólitos secundários presentes nas folhas de H. canum, dados ainda não descritos na literatura. As folhas e caules jovens coletados em Goiânia (GO foram seccionados à mão livre e preparados para análise microscópica. Foram realizadas reações de identificação de metabólitos secundários do material dessecado e pulverizado. Preparou-se o extrato etanólico bruto, que posteriormente foi fracionado por partição líquido-líquido com hexano, clorofórmio e acetato de etila. As frações foram submetidas à análise cromatográfica em camada delgada (CCD. As lâminas foliares apresentam epiderme adaxial constituída por células poligonais com parede reta. Na epiderme abaxial observam-se células com parede reta a ondulada e estômatos diacíticos e anisocíticos. Tricomas tectores e glandulares estão presente em ambas as faces da lâmina foliar. O pecíolo apresenta aspecto canaletado, epiderme adaxial e abaxial unisseriada. O caule, em secção transversal possui contorno em geral quadrangular, com presença de tricomas tectores e glandulares. As reações e a CCD das folhas evidenciaram a presença de flavonóides, saponinas, terpenos e lignanas. Este trabalho contribuiu para um maior conhecimento da morfo-anatomia e das classes químicas presentes em H. canum.

Factors affecting hydrocarbon removal by air stripping

International Nuclear Information System (INIS)

McFarland, W.E.

1992-01-01

This paper includes an overview of the theory of air stripping design considerations and the factors affecting stripper performance. Effects of temperature, contaminant characteristics, stripping tower geometry and air/water ratios on removal performance are discussed. The discussion includes treatment of groundwater contaminated with petroleum hydrocarbons and chlorinated solvents such as TCE and PCE. Control of VOC emissions from air strippers has become a major concern in recent years, due to more stringent restrictions on air quality in many areas. This paper includes an overview of available technology to control air emissions (including activated carbon adsorption, catalytic oxidation and steam stripping) and the effects of air emission control on overall efficiency of the treatment process. The paper includes an overview of the relative performance of various packing materials for air strippers and explains the relative advantages and disadvantages of comparative packing materials. Field conditions affecting selection of packing materials are also discussed. Practical guidelines for the design of air stripping systems are presented, as well as actual case studies of full-scale air stripping projects

Anatomia foliar de quatro espécies do gênero Cattleya Lindl. (Orchidaceae do Planalto Central Brasileiro Foliar anatomy of four species of genus Cattleya Lindl. (Orchidaceae of the Brazilian Central Planalt

Directory of Open Access Journals (Sweden)

Rosane Zanenga-Godoy

2003-03-01

Full Text Available As espécies analisadas (Cattleya araguaiensis Pabst, C. bicolor Lindl., C. nobilior Rchb. e C. walkeriana Gardn. apresentam epiderme uniestratificada em ambas as faces da lâmina foliar, ocorrendo estômatos na face abaxial; deposição de cera epicuticular em crostas, escamas, flocos e plaquetas; em C. araguaiensis ocorrem estegmatas incrustados nas células epidérmicas; em todas as espécies ocorre hipoderme com células de paredes espessadas; mesofilo bifacial, compacto; células paliçádicas atípicas, com barras de espessamento; feixes vasculares colaterais dispostos alternadamente, acompanhados por bainha de fibras; cordões fibrosos acompanhados por estegmatas ocorrem longitudinalmente na lâmina foliar; presença de ráfides. Os aspectos descritos revelam acentuada xeromorfia, em função de economia de água.The analyzed species (Cattleya araguaiensis Pabst, C. bicolor Lindl., C. nobilior Rchb. e C. walkeriana Gardn. present unistratified epidermis at both surfaces with stomata at abaxial surface; deposition of epicuticular wax in crusts, scales, granules and plates; C. araguaiensis presents stegmata at epidermal cells; others characteristics present at all species are: hypodermis cells with thick walls; bifacial and compact mesophyll; atipic cells ofpalisade parenchyma with thichness bars; collateral vascular bundles alternate accompanied by sheath fibers; cordon fibers accompanied by stegmata in the foliar blade; raphids. The described aspects reveal accentuate xeromorphy for water economy.

Magnetic stripping studies for SPL

CERN Document Server

Posocco, P; CERN. Geneva. BE Department

2010-01-01

Magnetic stripping of H- can seriously enhance the beam losses along the SPL machine. These losses depend on the beam energy, on the beam transverse distribution and on the intensity of the magnetic field. For radioprotection issues the losses must be limited to 1 W/m. In this paper we will concentrate on the stripping phenomena inside the quadrupole magnets with the aim of defining the quadrupole range for the design phase of SPL.

micro strip gas chamber

CERN Multimedia

1998-01-01

About 16 000 Micro Strip Gas Chambers like this one will be used in the CMS tracking detector. They will measure the tracks of charged particles to a hundredth of a millimetre precision in the region near the collision point where the density of particles is very high. Each chamber is filled with a gas mixture of argon and dimethyl ether. Charged particles passing through ionise the gas, knocking out electrons which are collected on the aluminium strips visible under the microscope. Such detectors are being used in radiography. They give higher resolution imaging and reduce the required dose of radiation.

Microstructural research on hot strips of low carbon steel produced by a compact strip production line under different thermal histories

International Nuclear Information System (INIS)

Yu Hao; Chen Qixiang; Kang Yonglin; Sun Yi

2005-01-01

Coupons with the same composition and thickness (4.0 mm nominal gauge) obtained from hot strips of low carbon steel underwent a series of investigations to analyze the microstructural characteristics and mechanisms responsible for their differences in mechanical properties. Two different industrial technologies were adopted, although the strips used in this research were produced on the same Compact Strip Production (CSP) line. One of the strips was produced with a routine γ→α CSP thermal history, but the other with a γ→α→γ* conventional thermal history. The only difference between them was that one technology had a α→γ* thermal history. Different specimens of both types of strips were prepared for metallographic observation, tensile tests, electron back-scattered diffraction tests and positron annihilation technique tests. Experimental results showed that the differences in mechanical properties could be ascribed to dissimilarities not only in the grain size and textural components but also in dislocation density

High Pressure Water Stripping Using Multi-Orifice Nozzles

Science.gov (United States)

Hoppe, David

1999-01-01

The use of multi-orifice rotary nozzles greatly increases the speed and stripping effectiveness of high pressure water blasting systems, but also greatly increases the complexity of selecting and optimizing the operating parameters. The rotational speed of the nozzle must be coupled with its transverse velocity as it passes across the surface of the substrate being stripped. The radial and angular positions of each orifice must be included in the analysis of the nozzle configuration. Orifices at the outer edge of the nozzle head move at a faster rate than the orifices located near the center. The energy transmitted to the surface from the impact force of the water stream from an outer orifice is therefore spread over a larger area than energy from an inner orifice. Utilizing a larger diameter orifice in the outer radial positions increases the total energy transmitted from the outer orifice to compensate for the wider distribution of energy. The total flow rate from the combination of all orifices must be monitored and should be kept below the pump capacity while choosing orifice to insert in each position. The energy distribution from the orifice pattern is further complicated since the rotary path of all the orifices in the nozzle head pass through the center section. All orifices contribute to the stripping in the center of the path while only the outer most orifice contributes to the stripping at the edge of the nozzle. Additional orifices contribute to the stripping from the outer edge toward the center section. With all these parameters to configure and each parameter change affecting the others, a computer model was developed to track and coordinate these parameters. The computer simulation graphically indicates the cumulative affect from each parameter selected. The result from the proper choices in parameters is a well designed, highly efficient stripping system. A poorly chosen set of parameters will cause the nozzle to strip aggressively in some areas

Anatomia foliar de quatro espécies do gênero Cattleya Lindl. (Orchidaceae) do Planalto Central Brasileiro Foliar anatomy of four species of genus Cattleya Lindl. (Orchidaceae) of the Brazilian Central Planalt

OpenAIRE

Rosane Zanenga-Godoy; Cecilia Gonçalves Costa

2003-01-01

As espécies analisadas (Cattleya araguaiensis Pabst, C. bicolor Lindl., C. nobilior Rchb. e C. walkeriana Gardn.) apresentam epiderme uniestratificada em ambas as faces da lâmina foliar, ocorrendo estômatos na face abaxial; deposição de cera epicuticular em crostas, escamas, flocos e plaquetas; em C. araguaiensis ocorrem estegmatas incrustados nas células epidérmicas; em todas as espécies ocorre hipoderme com células de paredes espessadas; mesofilo bifacial, compacto; células paliçádicas atíp...

Biochemistry of epidermal stem cells.

Science.gov (United States)

Eckert, Richard L; Adhikary, Gautam; Balasubramanian, Sivaprakasam; Rorke, Ellen A; Vemuri, Mohan C; Boucher, Shayne E; Bickenbach, Jackie R; Kerr, Candace

2013-02-01

The epidermis is an important protective barrier that is essential for maintenance of life. Maintaining this barrier requires continuous cell proliferation and differentiation. Moreover, these processes must be balanced to produce a normal epidermis. The stem cells of the epidermis reside in specific locations in the basal epidermis, hair follicle and sebaceous glands and these cells are responsible for replenishment of this tissue. A great deal of effort has gone into identifying protein epitopes that mark stem cells, in identifying stem cell niche locations, and in understanding how stem cell populations are related. We discuss these studies as they apply to understanding normal epidermal homeostasis and skin cancer. An assortment of stem cell markers have been identified that permit assignment of stem cells to specific regions of the epidermis, and progress has been made in understanding the role of these cells in normal epidermal homeostasis and in conditions of tissue stress. A key finding is the multiple stem cell populations exist in epidermis that give rise to different structures, and that multiple stem cell types may contribute to repair in damaged epidermis. Understanding epidermal stem cell biology is likely to lead to important therapies for treating skin diseases and cancer, and will also contribute to our understanding of stem cells in other systems. This article is part of a Special Issue entitled Biochemistry of Stem Cells. Copyright © 2012 Elsevier B.V. All rights reserved.

Biochemistry of epidermal stem cells☆

Science.gov (United States)

Eckert, Richard L.; Adhikary, Gautam; Balasubramanian, Sivaprakasam; Rorke, Ellen A.; Vemuri, Mohan C.; Boucher, Shayne E.; Bickenbach, Jackie R.; Kerr, Candace

2014-01-01

Background The epidermis is an important protective barrier that is essential for maintenance of life. Maintaining this barrier requires continuous cell proliferation and differentiation. Moreover, these processes must be balanced to produce a normal epidermis. The stem cells of the epidermis reside in specific locations in the basal epidermis, hair follicle and sebaceous glands and these cells are responsible for replenishment of this tissue. Scope of review A great deal of effort has gone into identifying protein epitopes that mark stem cells, in identifying stem cell niche locations, and in understanding how stem cell populations are related. We discuss these studies as they apply to understanding normal epidermal homeostasis and skin cancer. Major conclusions An assortment of stem cell markers have been identified that permit assignment of stem cells to specific regions of the epidermis, and progress has been made in understanding the role of these cells in normal epidermal homeostasis and in conditions of tissue stress. A key finding is the multiple stem cell populations exist in epidermis that give rise to different structures, and that multiple stem cell types may contribute to repair in damaged epidermis. General significance Understanding epidermal stem cell biology is likely to lead to important therapies for treating skin diseases and cancer, and will also contribute to our understanding of stem cells in other systems. This article is part of a Special Issue entitled Biochemistry of Stem Cells. PMID:22820019

Evolution of dinosaur epidermal structures.

Science.gov (United States)

Barrett, Paul M; Evans, David C; Campione, Nicolás E

2015-06-01

Spectacularly preserved non-avian dinosaurs with integumentary filaments/feathers have revolutionized dinosaur studies and fostered the suggestion that the dinosaur common ancestor possessed complex integumentary structures homologous to feathers. This hypothesis has major implications for interpreting dinosaur biology, but has not been tested rigorously. Using a comprehensive database of dinosaur skin traces, we apply maximum-likelihood methods to reconstruct the phylogenetic distribution of epidermal structures and interpret their evolutionary history. Most of these analyses find no compelling evidence for the appearance of protofeathers in the dinosaur common ancestor and scales are usually recovered as the plesiomorphic state, but results are sensitive to the outgroup condition in pterosaurs. Rare occurrences of ornithischian filamentous integument might represent independent acquisitions of novel epidermal structures that are not homologous with theropod feathers. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Properties isotropy of magnesium alloy strip workpieces

Directory of Open Access Journals (Sweden)

Р. Кавалла

2016-12-01

Full Text Available The paper discusses the issue of obtaining high quality cast workpieces of magnesium alloys produced by strip roll-casting. Producing strips of magnesium alloys by combining the processes of casting and rolling when liquid melt is fed continuously to fast rolls is quite promising and economic. In the process of sheet stamping considerable losses of metal occur on festoons formed due to anisotropy of properties of foil workpiece, as defined by the macro- and microstructure and modes of rolling and annealing. The principal causes of anisotropic mechanical properties of metal strips produced by the combined casting and rolling technique are the character of distribution of intermetallic compounds in the strip, orientation of phases of metal defects and the residual tensions. One of the tasks in increasing the output of fit products during stamping operations consists in minimizing the amount of defects. To lower the level of anisotropy in mechanical properties various ways of treating the melt during casting are suggested. Designing the technology of producing strips of magnesium alloys opens a possibility of using them in automobile industry to manufacture light-weight body elements instead of those made of steel.

Evaluation of silicon micro strip detectors with large read-out pitch

International Nuclear Information System (INIS)

Senyo, K.; Yamamura, K.; Tsuboyama, T.; Avrillon, S.; Asano, Y.; Bozek, A.; Natkaniec, Z.; Palka, H.; Rozanska, M.; Rybicki, K.

1996-01-01

For the development of the silicon micro-strip detector with the pitch of the readout strips as large as 250 μm on the ohmic side, we made samples with different structures. Charge collection was evaluated to optimize the width of implant strips, aluminum read-out strips, and/or the read-out scheme among strips. (orig.)

Micro-strip sensors based on CVD diamond

Energy Technology Data Exchange (ETDEWEB)

Adam, W.; Berdermann, E.; Bergonzo, P.; Bertuccio, G.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; D' Angelo, P.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; Eijk, B. van; Fallou, A.; Fizzotti, F.; Foulon, F.; Friedl, M.; Gan, K.K.; Gheeraert, E.; Hallewell, G.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Kass, R.; Koeth, T.; Krammer, M.; Logiudice, A.; Lu, R.; Mac Lynne, L.; Manfredotti, C.; Meier, D. E-mail: dirk.meier@cern.ch; Mishina, M.; Moroni, L.; Oh, A.; Pan, L.S.; Pernicka, M.; Peitz, A.; Perera, L.; Pirollo, S.; Procario, M.; Riester, J.L.; Roe, S.; Rousseau, L.; Rudge, A.; Russ, J.; Sala, S.; Sampietro, M.; Schnetzer, S.; Sciortino, S.; Stelzer, H.; Stone, R.; Suter, B.; Tapper, R.J.; Tesarek, R.; Trischuk, W.; Tromson, D.; Vittone, E.; Walsh, A.M.; Wedenig, R.; Weilhammer, P.; Wetstein, M.; White, C.; Zeuner, W.; Zoeller, M

2000-10-11

In this article we present the performance of recent chemical vapour deposition (CVD) diamond micro-strip sensors in beam tests. In addition, we present the first comparison of a CVD diamond micro-strip sensor before and after proton irradiation.

Micro-strip sensors based on CVD Diamond

CERN Document Server

Adam, W; Bergonzo, P; Bertuccio, G; Bogani, F; Borchi, E; Brambilla, A; Bruzzi, Mara; Colledani, C; Conway, J; D'Angelo, P; Dabrowski, W; Delpierre, P A; Deneuville, A; Dulinski, W; van Eijk, B; Fallou, A; Fizzotti, F; Foulon, F; Friedl, M; Gan, K K; Gheeraert, E; Hallewell, G D; Han, S; Hartjes, F G; Hrubec, Josef; Husson, D; Kagan, H; Kania, D R; Kaplon, J; Kass, R; Koeth, T W; Krammer, Manfred; Lo Giudice, A; Lü, R; MacLynne, L; Manfredotti, C; Meier, D; Mishina, M; Moroni, L; Oh, A; Pan, L S; Pernicka, Manfred; Peitz, A; Perera, L P; Pirollo, S; Procario, M; Riester, J L; Roe, S; Rousseau, L; Rudge, A; Russ, J; Sala, S; Sampietro, M; Schnetzer, S R; Sciortino, S; Stelzer, H; Stone, R; Suter, B; Tapper, R J; Tesarek, R J; Trischuk, W; Tromson, D; Vittone, E; Walsh, A M; Wedenig, R; Weilhammer, Peter; Wetstein, M; White, C; Zeuner, W; Zoeller, M M

2000-01-01

In this article we present the performance of recent chemical vapour deposition (CVD) diamond micro-strip sensors in beam tests. In addition we present the first comparison of a CVD diamond micro-strip sensor before and after proton irradiation.

Micro-strip sensors based on CVD diamond

International Nuclear Information System (INIS)

Adam, W.; Berdermann, E.; Bergonzo, P.; Bertuccio, G.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; D'Angelo, P.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; Eijk, B. van; Fallou, A.; Fizzotti, F.; Foulon, F.; Friedl, M.; Gan, K.K.; Gheeraert, E.; Hallewell, G.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Kass, R.; Koeth, T.; Krammer, M.; Logiudice, A.; Lu, R.; Mac Lynne, L.; Manfredotti, C.; Meier, D.; Mishina, M.; Moroni, L.; Oh, A.; Pan, L.S.; Pernicka, M.; Peitz, A.; Perera, L.; Pirollo, S.; Procario, M.; Riester, J.L.; Roe, S.; Rousseau, L.; Rudge, A.; Russ, J.; Sala, S.; Sampietro, M.; Schnetzer, S.; Sciortino, S.; Stelzer, H.; Stone, R.; Suter, B.; Tapper, R.J.; Tesarek, R.; Trischuk, W.; Tromson, D.; Vittone, E.; Walsh, A.M.; Wedenig, R.; Weilhammer, P.; Wetstein, M.; White, C.; Zeuner, W.; Zoeller, M.

2000-01-01

In this article we present the performance of recent chemical vapour deposition (CVD) diamond micro-strip sensors in beam tests. In addition, we present the first comparison of a CVD diamond micro-strip sensor before and after proton irradiation

Micro-strip sensors based on CVD diamond

Science.gov (United States)

Adam, W.; Berdermann, E.; Bergonzo, P.; Bertuccio, G.; Bogani, F.; Borchi, E.; Brambilla, A.; Bruzzi, M.; Colledani, C.; Conway, J.; D'Angelo, P.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; van Eijk, B.; Fallou, A.; Fizzotti, F.; Foulon, F.; Friedl, M.; Gan, K. K.; Gheeraert, E.; Hallewell, G.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Kass, R.; Koeth, T.; Krammer, M.; Logiudice, A.; Lu, R.; mac Lynne, L.; Manfredotti, C.; Meier, D.; Mishina, M.; Moroni, L.; Oh, A.; Pan, L. S.; Pernicka, M.; Peitz, A.; Perera, L.; Pirollo, S.; Procario, M.; Riester, J. L.; Roe, S.; Rousseau, L.; Rudge, A.; Russ, J.; Sala, S.; Sampietro, M.; Schnetzer, S.; Sciortino, S.; Stelzer, H.; Stone, R.; Suter, B.; Tapper, R. J.; Tesarek, R.; Trischuk, W.; Tromson, D.; Vittone, E.; Walsh, A. M.; Wedenig, R.; Weilhammer, P.; Wetstein, M.; White, C.; Zeuner, W.; Zoeller, M.; RD42 Collaboration

2000-10-01

In this article we present the performance of recent chemical vapour deposition (CVD) diamond micro-strip sensors in beam tests. In addition, we present the first comparison of a CVD diamond micro-strip sensor before and after proton irradiation.

Membrane air stripping utilizing a plate and frame configuration

International Nuclear Information System (INIS)

Boswell, S.T.

1991-01-01

Membrane air stripping has recently been proposed as a possible method to remove volatile organic chemicals (VOCs) and radon from drinking water supplies. Current and anticipated regulatory requirements, driven by health consequences, make the removal of these contaminants mandatory. This work examines the use of plate and frame membrane air stripping for the removal of VOCs and radon from a water supply. The theoretical basis of membrane air stripping and a literature review are included. The advantages of membrane air stripping versus other methods of removal, as well as the advantages of a plate and frame configuration versus a hollow fiber configuration for membrane air stripping are discussed. Multiple regression/correlation techniques are used to model mass transfer coefficients and fluid resistances. An economic evaluation is performed using the developed models. The costs of comparable membrane and packed tower air stripping systems are 4.86 cents per thousand gallons versus 4.36 cents per thousand gallons, respectively. This work indicates that plate and frame membrane air stripping may, in fact, prove to be an economical alternative to packed tower aeration and carbon adsorption for the removal of VOCs and radon

Advection endash diffusion past a strip. II. Oblique incidence

International Nuclear Information System (INIS)

Knessl, C.; Keller, J.B.

1997-01-01

Advection and diffusion of particles past an impenetrable strip is considered when the strip is oblique to the advection or drift velocity. The particle concentration p(x,y) is determined asymptotically for large values of vL/D, where v is the drift velocity, D is the diffusion coefficient, and 2L is the width of the strip. The results complement those of Part I, which treated a strip normal to the drift velocity. copyright 1997 American Institute of Physics

Stripping of uranium from Dehpa/kerosene solvents by different aqueous media

International Nuclear Information System (INIS)

Khorfan, S.; Stas, J.; Kassem, M.

1998-01-01

Stripping uranium from Dehpa/kerosene solvent is a crucial step in the recovery of uranium. Stripping was studied using different stripping media mainly ammonium carbonate, phosphoric acid, sulfuric acid, hydrochloric acid and nitric acid. Stripping was measured at different operating conditions such as aqueous concentrations, temperatures, and Dehpa/kerosene concentrations. The results obtained showed that stripping by acid media increases with the acid concentration and follows the order: HF > H 3 PO 4 > H 2 SO 4 > HCl > HNO 3 . To achieve higher stripping by phosphoric acid it was found necessary to increase the temperature to 50 deg C, the acid concentration to 5 mol/l and to reduce the uranium to U 4+ . Stripping by basic media was found to increase with increasing concentration of the stripping media and to follow the order: Na 2 CO 3 > (NH 4 ) 2 CO 3 > NH 4 HCO 3 . Stripping by ammonium carbonate was found to increase with temperature and carbonate concentration. The stripping was optimized at 0.5 mol/l carbonate concentration and at a temperature of 50 deg C. Stripping was decreased by increasing concentration of Dehpa in kerosene and was depressed more by adding the synergant Topo to the Dehpa solvent especially at 1/4 mol/mol ratio. (author)

Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis

International Nuclear Information System (INIS)

Maganga, Richard; Giles, Natalie; Adcroft, Katharine; Unni, Ambili; Keeney, Diane; Wood, Fiona; Fear, Mark; Dharmarajan, Arunasalam

2008-01-01

The skin provides vital protection from infection and dehydration. Maintenance of the skin is through a constant program of proliferation, differentiation and apoptosis of epidermal cells, whereby proliferating cells in the basal layer differentiating to form the keratinized, anucleated stratum corneum. The WNT signalling pathway is known to be important in the skin. WNT signalling has been shown to be important both in epidermal development and in the maintenance and cycling of hair follicles and epidermal stem cells. However, the precise role for this pathway in epidermal differentiation remains unknown. We investigated the role of the WNT signalling inhibitor sFRP4 in epidermal differentiation. sFRP4 is expressed in both normal skin and keratinocytes in culture. Expression of sFRP4 mRNA and protein increases with keratinocyte differentiation and apoptosis, whilst exposure of keratinocytes to exogenous sFRP4 promotes apoptosis and expression of the terminal differentiation marker Involucrin. These data suggest sFRP4 promotes epidermal differentiation.

Oxygen dependency of epidermal growth factor receptor binding and DNA synthesis of rat hepatocytes

International Nuclear Information System (INIS)

Hirose, Tetsuro; Terajima, Hiroaki; Yamauchi, Akira

1997-01-01

Background/Aims: Changes in oxygen availability modulate replicative responses in several cell types, but the effects on hepatocyte replication remain unclear. We have studied the effects of transient nonlethal hypoxia on epidermal growth factor receptor binding and epidermal growth factor-induced DNA synthesis of rat hepatocytes. Methods: Lactate dehydrogenase activity in culture supernatant, intracellular adenosine triphosphate content, 125 I-epidermal growth factor specific binding, epidermal growth factor receptor protein expression, and 3 H-thymidine incorporation were compared between hepatocytes cultured in hypoxia and normoxia. Results: Hypoxia up to 3 h caused no significant increase in lactate dehydrogenase activity in the culture supernatant, while intracellular adenosine triphosphate content decreased time-dependently and was restored to normoxic levels by reoxygenation (nonlethal hypoxia). Concomitantly, 125 I-epidermal growth factor specific binding to hepatocytes decreased time-dependently (to 54.1% of normoxia) and was restored to control levels by reoxygenation, although 125 I-insulin specific binding was not affected. The decrease in 125 I-epidermal growth factor specific binding was explained by the decrease in the number or available epidermal growth factor receptors (21.37±3.08 to 12.16±1.42 fmol/10 5 cells), while the dissociation constant of the receptor was not affected. The change in the number of available receptors was not considered to be due to receptor degradation-resynthesis, since immuno-detection of the epidermal growth factor receptor revealed that the receptor protein expression did not change during hypoxia and reoxygenation, and since neither actinomycin D nor cycloheximide affected the recovery of 125 I-epidermal growth factor binding by reoxygenation. Inhibition of epidermal growth factor-induced DNA synthesis after hypoxia (to 75.4% of normoxia by 3 h hypoxia) paralleled the decrease in 125 I-epidermal growth factor binding

Stage- vs. Channel-strip Metaphor

DEFF Research Database (Denmark)

Gelineck, Steven; Korsgaard, Dannie Michael; Büchert, Morten

2015-01-01

This study compares the stage metaphor and the channel strip metaphor in terms of performance. Traditionally, music mixing consoles employ a channels strip control metaphor for adjusting parameters such as volume and panning of each track. An alternative control metaphor, the so-called stage meta...... is surprisingly similar and thus we are not able to detect any significant difference in performance between the two interfaces. Qualitative data however, suggests that the stage metaphor is largely favoured for its intuitive interaction - confirming earlier studies....

Padrão estomático de Capsicum ssp. resistentes e suscetíveis a Oidiopsis haplophylli Stomatal patterns of Capsicum genotypes resistant or susceptible to Oidiopsis haplophylli

Directory of Open Access Journals (Sweden)

Milton Luiz Paz Lima

2010-03-01

Full Text Available Visando relacionar a reação de Capsicum spp. resistentes e suscetíveis à Oidiopsis haplophylli com o padrão dos respectivos complexos estomáticos, foram analisados em dois ensaios, 5 e 15 genótipos de Capsicum spp. em delineamento inteiramente casualizado. Avaliou-se a abertura do ostíolo, a morfometria do estômato (comprimento, largura e área, o número de estômatos.mm-2 e a freqüência de estômatos (unidades de estômatos por células da epiderme nas superfícies adaxial e abaxial da epiderme foliar de plantas cultivadas em casa-de-vegetação. A variável abertura ostiolar não explicou a reação dos genótipos ao oídio, nem na face adaxial (R²=0,16 nem na abaxial (R²=0,13. Entretanto, o número de estômatos.mm-2 explicou a reação ao oídio em 84 % (face adaxial ou 74 % (face abaxial. Para a freqüência de estômatos, o modelo ajustou-se melhor na face adaxial (R² = 0,76, do que na face abaxial (R²=0,48. Maiores números e freqüências de estômatos em ambas as faces foliares ocorreram em pimentão 'Magali' (altamente suscetível, com valores significativamente maiores do que em 'HV-12' (altamente resistente. Sugere-se que a suscetibilidade de genótipos de Capsicum a O. haplophylli está parcialmente relacionada a mecanismos de defesa estruturais pré-formados, como o número e freqüência de estômatos, os quais se relacionam com o número de sítios de infecção. Por outro lado, para alguns genótipos, esta relação não foi significativa, indicando que outros mecanismos de resistência também estejam envolvidos.This work reports the reaction of Capsicum genotypes to the powdery mildew pathogen with variables of the stomatal complex, from samples of five to 15 Capsicum genotypes in a complete randomized experiments. Ostiolum size, stomatal morphometry (length, width and surface area, the number of stomata.mm-2, and the frequency of stomata (stomatal units per unit of epidermal cells were evaluated on both leaf

Study of inter-strip gap effects and efficiency for full energy detection of double sided silicon strip detectors

International Nuclear Information System (INIS)

Fisichella, M.; Forneris, J.; Grassi, L.

2015-01-01

We performed a characterization of Double Sided Silicon Strip Detectors (DSSSD) with the aim to carry out a systematic study of the inter-strip effects on the energy measurement of charged particles. The dependence of the DSSSD response on ion, energy and applied bias has been investigated. (author)

Stripping of uranium from Dehpa/Kerosene solvents by different aqueous media

International Nuclear Information System (INIS)

Khorfan, S.; Stas, J.; Kassem, M.

2000-01-01

Stripping uranium from Dehpa/kerosene solvent is a crucial step in the recovery of uranium. Stripping was studied using different stripping media mainly ammonium carbonate, phosphoric acid, sulfuric acid, hydrochloric acid and nitric acid. Stripping was measured at different operating conditions such as aqueous concentrations, temperatures, and Dehpa/kerosene concentrations. The results obtained showed that stripping by acid media increases with the acid concentration and follows the order: HF > H sub 3 Po sub 4 > H sub 2 S O sub 4 > HCl > HNO sub 3. To achieve higher stripping by phosphoric acid it was found necessary to increase the temperature to 50 deg C, the acid concentration to 5 mol/l and to reduce the uranium to U sup 4 sup +. Stripping by basic media was found to increase with increasing concentration of the stripping media and to follow the order: Na sub 2 CO sub 3 > (NH sub 4) sub 2 CO sub 3 > NH sub 4 HCO sub 3. Stripping by ammonium carbonate was found to increase with temperature and carbonate concentration. The stripping was optimized at 0.5 mol/l carbonate concentration and at a temperature of 50 deg C. Stripping was decreased by increasing concentration of Dehpa in kerosene and was depressed more by adding the synergant TOPO to the Dehpa solvent especially at 1/4 mol/mol ratio. (author)

Strip defect recognition in electrical tests of silicon microstrip sensors

Energy Technology Data Exchange (ETDEWEB)

Valentan, Manfred, E-mail: valentan@mpp.mpg.de

2017-02-11

This contribution describes the measurement procedure and data analysis of AC-coupled double-sided silicon microstrip sensors with polysilicon resistor biasing. The most thorough test of a strip sensor is an electrical measurement of all strips of the sensor; the measured observables include e.g. the strip's current and the coupling capacitance. These measurements are performed to find defective strips, e.g. broken capacitors (pinholes) or implant shorts between two adjacent strips. When a strip has a defect, its observables will show a deviation from the “typical value”. To recognize and quantify certain defects, it is necessary to determine these typical values, i.e. the values the observables would have without the defect. As a novel approach, local least-median-of-squares linear fits are applied to determine these “would-be” values of the observables. A least-median-of-squares fit is robust against outliers, i.e. it ignores the observable values of defective strips. Knowing the typical values allows to recognize, distinguish and quantify a whole range of strip defects. This contribution explains how the various defects appear in the data and in which order the defects can be recognized. The method has been used to find strip defects on 30 double-sided trapezoidal microstrip sensors for the Belle II Silicon Vertex Detector, which have been measured at the Institute of High Energy Physics, Vienna (Austria).

Strip type radiation detector and method of making same

International Nuclear Information System (INIS)

Jantsch, O.; Feigt, I.; Willig, W.R.

1976-01-01

An improved strip detector and a method for making such a detector in which a high resistivity N conduction semiconductor body has electrode strips formed thereon by diffusion is described. The strips are formed so as to be covered by an oxide layer at the surface point of the PN junction and in which the opposite side of the semiconductor body then has a substantial amount of material etched away to form a thin semiconductor upon which strip electrodes which are perpendicular to the electrodes on the first side are then placed

Stripping voltammetry in environmental and food analysis.

Science.gov (United States)

Brainina, K Z; Malakhova, N A; Stojko, N Y

2000-10-01

The review covers over 230 papers published mostly in the last 5 years. The goal of the review is to attract the attention of researchers and users to stripping voltammetry in particular, its application in environmental monitoring and analysis of foodstuffs. The sensors employed are impregnated graphite, carbon paste, thick film carbon/graphite and thin film metallic electrodes modified in-situ or beforehand. Hanging mercury drop electrodes and mercury coated glassy carbon electrodes are also mentioned. Strip and long-lived sensors for portable instruments and flow through systems are discussed as devices for future development and application of stripping voltammetry.

Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells.

Science.gov (United States)

Veltri, Anthony; Lang, Christopher; Lien, Wen-Hui

2018-01-01

Mammalian skin and its appendages constitute the integumentary system forming a barrier between the organism and its environment. During development, skin epidermal cells divide rapidly and stratify into a multilayered epithelium, as well as invaginate downward in the underlying mesenchyme to form hair follicles (HFs). In postnatal skin, the interfollicular epidermal (IFE) cells continuously proliferate and differentiate while HFs undergo cycles of regeneration. Epidermal regeneration is fueled by epidermal stem cells (SCs) located in the basal layer of the IFE and the outer layer of the bulge in the HF. Epidermal development and SC behavior are mainly regulated by various extrinsic cues, among which Wnt-dependent signaling pathways play crucial roles. This review not only summarizes the current knowledge of Wnt signaling pathways in the regulation of skin development and governance of SCs during tissue homeostasis, but also discusses the potential crosstalk of Wnt signaling with other pathways involved in these processes. Stem Cells 2018;36:22-35. © 2017 AlphaMed Press.

Penile epidermal inclusion cyst: a late complication of penile girth enhancement surgery.

Science.gov (United States)

Park, Hyun Jun; Park, Nam Cheol; Park, Sung Woo; Jern, Tae Kyung; Choi, Kyung-Un

2008-09-01

Epidermal inclusion cysts are benign lesions that can develop in any part of the body. However, the finding of an epidermal inclusion cyst in the penis is rare. The aim of this article was to present the management of a case of a penile epidermal inclusion cyst that occurred because of late complications of a penile girth enhancement surgery. A 52-year-old man presented with a painless, slowly growing mass in the penis, which was first noted after a penile girth enhancement surgery 20 years ago. A cystic mobile mass about 2 cm in depth was found surrounding the coronal sulcus. Excision of the mass was performed for diagnosis and treatment. There was no communication with the urethra. The pathological diagnosis was an epidermal inclusion cyst of the penis. A penile epidermal inclusion cyst in adult men is rare. It can develop after an inadequate procedure for penile girth enhancement, and should be treated by complete resection.

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Directory of Open Access Journals (Sweden)

Kazuhiko Arima

2015-01-01

Conclusions: Periostin plays an important role during epidermal hyperplasia in IMQ-induced skin inflammation, independently of the IL-23–IL-17/IL-22 axis. Periostin appears to be a mediator for epidermal hyperplasia that is common to AD and psoriasis.

Collisional stripping of planetary crusts

Science.gov (United States)

Carter, Philip J.; Leinhardt, Zoë M.; Elliott, Tim; Stewart, Sarah T.; Walter, Michael J.

2018-02-01

Geochemical studies of planetary accretion and evolution have invoked various degrees of collisional erosion to explain differences in bulk composition between planets and chondrites. Here we undertake a full, dynamical evaluation of 'crustal stripping' during accretion and its key geochemical consequences. Crusts are expected to contain a significant fraction of planetary budgets of incompatible elements, which include the major heat producing nuclides. We present smoothed particle hydrodynamics simulations of collisions between differentiated rocky planetesimals and planetary embryos. We find that the crust is preferentially lost relative to the mantle during impacts, and we have developed a scaling law based on these simulations that approximates the mass of crust that remains in the largest remnant. Using this scaling law and a recent set of N-body simulations of terrestrial planet formation, we have estimated the maximum effect of crustal stripping on incompatible element abundances during the accretion of planetary embryos. We find that on average approximately one third of the initial crust is stripped from embryos as they accrete, which leads to a reduction of ∼20% in the budgets of the heat producing elements if the stripped crust does not reaccrete. Erosion of crusts can lead to non-chondritic ratios of incompatible elements, but the magnitude of this effect depends sensitively on the details of the crust-forming melting process on the planetesimals. The Lu/Hf system is fractionated for a wide range of crustal formation scenarios. Using eucrites (the products of planetesimal silicate melting, thought to represent the crust of Vesta) as a guide to the Lu/Hf of planetesimal crust partially lost during accretion, we predict the Earth could evolve to a superchondritic 176Hf/177Hf (3-5 parts per ten thousand) at present day. Such values are in keeping with compositional estimates of the bulk Earth. Stripping of planetary crusts during accretion can lead to

An Epidermal Biosensor for Carcinoembryonic Antigen

National Research Council Canada - National Science Library

Schwartz, Pauline

2001-01-01

...). An epidermal biosensor is a new approach for the early continuous, in vivo detection of the onset of disease by the using genetically modified skin cells to respond to molecules secreted by tumor cells...

New Concept of Cultivation Using Limited Strip-Tillage with Strip Shallow Irrigation

Directory of Open Access Journals (Sweden)

Yazid Ismi Intara

2014-04-01

Full Text Available Normal 0 false false false IN X-NONE X-NONE Dry land is one of land resources which potentially used for food crop cultivation, especially in the areas which have light to medium technical obstacles. The development of technology to improve soil quality in marginal lands to be productive lands is still widely open for agricultural development in Indonesia. Rooting medium quality can be improved by changing soil tillage method and observing the proper crop irrigation technology. It can be the solution for crop cultivation in clay loam soil. This study aimed to obtain water movement model in a minimally-tilled clay soil with strip shallow irrigation. The concept is limited soil-tillage with strip shallow irrigation method, water supply technique, and crop water requirement. Method used in this study includes developing water movement model (software development in a minimally-tilled clay soil with subsurface irrigation. In the final stages, research also conducted water movement analysis testing apparatus in the laboratory, field validation of the subsurface irrigation performance, and cultivation technique testing to chili pepper growth (Capsicum annuumL.. The development of water movement simulation on a limited strip-tillage with subsurface irrigation uses the concept to quantify the amount of water in the soil. The analysis of movement pattern was demonstrated on contour patterns. It showed that the wetting process can reach depth zone – 5 cm to the rooting zone. It was an important discovery on the development of minimum stripe tillage soil with subsurface irrigation. Specifically, it can be concluded that: the result of fitting by eyes to diffusivity graphic and water content obtained the required parameter values for soil physical properties. It was then simulated on horizontal water movement model on a minimum strip-tillage with strip shallow irrigation /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso

Effects of in Utero Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Epidermal Permeability Barrier Development and Function

Science.gov (United States)

Muenyi, Clarisse S.; Carrion, Sandra Leon; Jones, Lynn A.; Kennedy, Lawrence H.; Slominski, Andrzej T.

2014-01-01

Background: Development of the epidermal permeability barrier (EPB) is essential for neonatal life. Defects in this barrier are found in many skin diseases such as atopic dermatitis. Objective: We investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development and function of the EPB. Methods: Timed-pregnant C57BL/6J mice were gavaged with corn oil or TCDD (10 μg/kg body weight) on gestation day 12. Embryos were harvested on embryonic day (E) 15, E16, E17, and postnatal day (PND) 1. Results: A skin permeability assay showed that TCDD accelerated the development of the EPB, beginning at E15. This was accompanied by a significant decrease in transepidermal water loss (TEWL), enhanced stratification, and formation of the stratum corneum (SC). The levels of several ceramides were significantly increased at E15 and E16. PND1 histology revealed TCDD-induced acanthosis and epidermal hyperkeratosis. This was accompanied by disrupted epidermal tight junction (TJ) function, with increased dye leakage at the terminal claudin-1–staining TJs of the stratum granulosum. Because the animals did not have enhanced rates of TEWL, a commonly observed phenotype in animals with TJ defects, we performed tape-stripping. Removal of most of the SC resulted in a significant increase in TEWL in TCDD-exposed PND1 pups compared with their control group. Conclusions: These findings demonstrate that in utero exposure to TCDD accelerates the formation of an abnormal EPB with leaky TJs, warranting further study of environmental exposures, epithelial TJ integrity, and atopic disease. Citation: Muenyi CS, Leon Carrion S, Jones LA, Kennedy LH, Slominski AT, Sutter CH, Sutter TR. 2014. Effects of in utero exposure of C57BL/6J mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin on epidermal permeability barrier development and function. Environ Health Perspect 122:1052–1058; http://dx.doi.org/10.1289/ehp.1308045 PMID:24904982

Strip specimen tests for pipeline materials and girth welds

Energy Technology Data Exchange (ETDEWEB)

Mohr, William C. [Edison Welding Institute (EWI), Columbus, Ohio (United States)

2009-07-01

Strip specimen testing of pipeline materials has been widely applied as a method of getting data relevant to the performance of pipelines under axial direction loading. Comparisons of strip specimen against smaller standard tests (round tensile bar, fracture toughness specimens, polished round bars) and against full-scale or large-scale testing will be explored. Data from early-generation pipe welds from the 1920's to the 1940's to the most recent materials for offshore reeled pipe will be used for examples. Strip samples can provide full thickness information to take account of varying material properties or imperfection distribution through the thickness. Strip samples can also accommodate measurement of effects of the original surface finish or weld surface shape. Strip samples have more design flexibility than standard tests, but must be designed to limit stress concentrations and effects of local bending. (author)

Optimal allocation of leaf epidermal area for gas exchange

OpenAIRE

de Boer, Hugo J.; Price, Charles A.; Wagner-Cremer, Friederike; Dekker, Stefan C.; Franks, Peter J.; Veneklaas, Erik J.

2016-01-01

Summary A long?standing research focus in phytology has been to understand how plants allocate leaf epidermal space to stomata in order to achieve an economic balance between the plant's carbon needs and water use. Here, we present a quantitative theoretical framework to predict allometric relationships between morphological stomatal traits in relation to leaf gas exchange and the required allocation of epidermal area to stomata. Our theoretical framework was derived from first principles of ...

Fatigue of graphite/epoxy buffer strip panels with center cracks

Science.gov (United States)

Bigelow, C. A.

1985-01-01

The effects of fatigue loading on the behavior of graphite/epoxy panels with either S-Glass or Kevlar-49 buffer strips is studied. Buffer strip panels are fatigued and tested in tension to measure their residual strength with crack-like damage. Panels are made with 45/0/-45/90 sub 2s layup with either S-Glass or Kevlar-49 buffer strip material. The buffer strips are parallel to the loading direction and made by replacing narrow strips of the 0-degree graphite plies with strips of either 0-degree S-Glass/epoxy or Kevlar-49/epoxy on a one-for-one basis. The panels are subjected to a fatigue loading spectrum MINITWIST, the shortened version of the standardized load program for the wing lower surface of a transport aircraft. Two levels of maximum strain are used in the spectrum with three durations of the fatigue spectrum. One group of panels is preloaded prior to the application of the fatigue cycling. The preload consists of statistically loading the spectrum in tension until the crack-tip damage zone reaches the ajacent buffer strips. After fatigue loading, all specimens are statistically loaded in tension to failure to determine their residual strengths.

An Epidermal Biosensor for Carcinoembryonic Antigen

National Research Council Canada - National Science Library

Schwartz, Pauline

2003-01-01

...) An epidermal biosensor was conceived as a new approach for the early continuous, in vivo detection of the onset of disease by the using genetically modified skin cells to respond to molecules secreted by tumor cells...

Photosensitive Strip RETHGEM

CERN Document Server

Peskov, Vladimir; Nappi, E.; Oliveira, R.; Paic, G.; Pietropaolo, F.; Picchi, P.

2008-01-01

An innovative photosensitive gaseous detector, consisting of a GEM like amplification structure with double layered electrodes (instead of commonly used metallic ones) coated with a CsI reflective photocathode, is described. In one of our latest designs, the inner electrode consists of a metallic grid and the outer one is made of resistive strips; the latter are manufactured by a screen printing technology on the top of the metallic strips grid The inner metallic grid is used for 2D position measurements whereas the resistive layer provides an efficient spark protected operation at high gains - close to the breakdown limit. Detectors with active areas of 10cm x10cm and 10cm x20cm were tested under various conditions including the operation in photosensitive gas mixtures containing ethylferrocene or TMAE vapors. The new technique could have many applications requiring robust and reliable large area detectors for UV visualization, as for example, in Cherenkov imaging devices.

Nanoscale Test Strips for Multiplexed Blood Analysis

Science.gov (United States)

Chan, Eugene

2015-01-01

A critical component of the DNA Medicine Institute's Reusable Handheld Electrolyte and Lab Technology for Humans (rHEALTH) sensor are nanoscale test strips, or nanostrips, that enable multiplexed blood analysis. Nanostrips are conceptually similar to the standard urinalysis test strip, but the strips are shrunk down a billionfold to the microscale. Each nanostrip can have several sensor pads that fluoresce in response to different targets in a sample. The strips carry identification tags that permit differentiation of a specific panel from hundreds of other nanostrip panels during a single measurement session. In Phase I of the project, the company fabricated, tested, and demonstrated functional parathyroid hormone and vitamin D nanostrips for bone metabolism, and thrombin aptamer and immunoglobulin G antibody nanostrips. In Phase II, numerous nanostrips were developed to address key space flight-based medical needs: assessment of bone metabolism, immune response, cardiac status, liver metabolism, and lipid profiles. This unique approach holds genuine promise for space-based portable biodiagnostics and for point-of-care (POC) health monitoring and diagnostics here on Earth.

Data acquisition software for the CMS strip tracker

International Nuclear Information System (INIS)

Bainbridge, R; Cripps, N; Fulcher, J; Radicci, V; Wingham, M; Baulieu, G; Bel, S; Delaere, C; Drouhin, F; Gill, K; Mirabito, L; Cole, J; Jesus, A C A; Giassi, A; Giordano, D; Gross, L; Hahn, K; Mersi, S; Nikolic, M; Tkaczyk, S

2008-01-01

The CMS silicon strip tracker, providing a sensitive area of approximately 200 m 2 and comprising 10 million readout channels, has recently been completed at the tracker integration facility at CERN. The strip tracker community is currently working to develop and integrate the online and offline software frameworks, known as XDAQ and CMSSW respectively, for the purposes of data acquisition and detector commissioning and monitoring. Recent developments have seen the integration of many new services and tools within the online data acquisition system, such as event building, online distributed analysis, an online monitoring framework, and data storage management. We review the various software components that comprise the strip tracker data acquisition system, the software architectures used for stand-alone and global data-taking modes. Our experiences in commissioning and operating one of the largest ever silicon micro-strip tracking systems are also reviewed

The development of drift-strip detectors based on CdZnTe

DEFF Research Database (Denmark)

Gostilo, V.; Budtz-Jørgensen, Carl; Kuvvetli, Irfan

2002-01-01

The design and technological development of a CdZnTe drift strip detector is described. The device is based on a monocrystal of dimensions 10 x 10 x 3 mm(3) and has a pitch of 200 mum and a strip width of 100 mum. The strip length is 9.5 mm. The distribution of the leakage currents of the strips...

Eddy current distribution and lift force for finite MAGLEV strips

Energy Technology Data Exchange (ETDEWEB)

Atherton, D L; Eastham, A R; Fombrun, C; Chong, M

1974-07-01

The transverse distribution of induced eddy currents across a flat conducing strip of finite width, due to a rectangular dc magnet moving above it, was modelled experimentally, and was compared with that calculated for an infinite sheet. The electrodynamic suspension was simulated by means of a stationary ac-excited copper magnet suspended above an aluminum strip, and the induced surface current density was measured by a voltage pickup probe connected to a lock-in amplifier. The effect of reducing strip width is examined and shown to produce high current densities close to the edges. These results are related to the variation of lift force with strip width, determined by impedance modelling. A slight enhancement of lift is evident for intermediate strip widths.

Epidermal growth in the bottlenose dolphin, Tursiops truncatus

International Nuclear Information System (INIS)

Hicks, B.D.; St Aubin, D.J.; Geraci, J.R.; Brown, W.R.

1985-01-01

Epidermal growth in two mature female bottlenose dolphins, Tursiops truncatus, was investigated by following the movement of a cohort of tritiated thymidine-labeled epidermal cells for 59 days. The majority of the cells migrated in a cluster which was estimated to reach the skin surface in 73 days. The authors calculate that the outermost cell layer is sloughed 12 times per day. Turnover time and sloughing rate are estimated to be 1.7 times longer and 8.5 times faster than the respective values for epidermal cell kinetics in humans. This apparent inconsistency of slow transit time and rapid sloughing rate is reconciled by the convoluted structure of the stratum germinativum in the dolphin which results in a ratio of germinatival to superficial cells of 876:1. The stratum germinativum of dolphin epidermis appears to lack morphologically distinct, spatially segregated subpopulations of anchoring and stem cells. Dolphin epidermis has a large capacity for cell population, relatively long turnover time, and rapid sloughing rate. The adaptive advantages of these characteristics are discussed

Epidermal growth in the bottlenose dolphin, Tursiops truncatus

Energy Technology Data Exchange (ETDEWEB)

Hicks, B.D.; St. Aubin, D.J.; Geraci, J.R.; Brown, W.R.

1985-07-01

Epidermal growth in two mature female bottlenose dolphins, Tursiops truncatus, was investigated by following the movement of a cohort of tritiated thymidine-labeled epidermal cells for 59 days. The majority of the cells migrated in a cluster which was estimated to reach the skin surface in 73 days. The authors calculate that the outermost cell layer is sloughed 12 times per day. Turnover time and sloughing rate are estimated to be 1.7 times longer and 8.5 times faster than the respective values for epidermal cell kinetics in humans. This apparent inconsistency of slow transit time and rapid sloughing rate is reconciled by the convoluted structure of the stratum germinativum in the dolphin which results in a ratio of germinatival to superficial cells of 876:1. The stratum germinativum of dolphin epidermis appears to lack morphologically distinct, spatially segregated subpopulations of anchoring and stem cells. Dolphin epidermis has a large capacity for cell population, relatively long turnover time, and rapid sloughing rate. The adaptive advantages of these characteristics are discussed.

Deuteron stripping reactions using dirac phenomenology

Science.gov (United States)

Hawk, E. A.; McNeil, J. A.

2001-04-01

In this work deuteron stripping reactions are studied using the distorted wave born approximation employing dirac phenomenological potentials. In 1982 Shepard and Rost performed zero-range dirac phenomenological stripping calculations and found a dramatic reduction in the predicted cross sections when compared with similar nonrelativistic calculations. We extend the earlier work by including full finite range effects as well as the deuteron's internal D-state. Results will be compared with traditional nonrelativistic approaches and experimental data at low energy.

LYCORIS - A Large Area Strip Telescope

CERN Document Server

Krämer, U; Stanitzki, M; Wu, M

2018-01-01

The LYCORIS Large Area Silicon Strip Telescope for the DESY II Test Beam Facility is presented. The DESY II Test Beam Facility provides elec- tron and positron beams for beam tests of up to 6 GeV. A new telescope with a large 10 × 20 cm2 coverage area based on a 25 μm pitch strip sensor is to be installed within the PCMAG 1 T solenoid. The current state of the system is presented.

Combined effect of bulk and surface damage on strip insulation properties of proton irradiated n$^{+}$-p silicon strip sensors

CERN Document Server

Dalal, R; Ranjan, K; Moll, M; Elliott-Peisert, A

2014-01-01

Silicon sensors in next generation hadron colliders willface a tremendously harsh radiation environment. Requirement tostudy rarest reaction channels with statistical constraints hasresulted in a huge increment in radiation flux, resulting in bothsurface damage and bulk damage. For sensors which are used in acharged hadron environment, both of these degrading processes takeplace simultaneously. Recently it has been observed in protonirradiated n$^{+}$-p Si strip sensors that n$^{+}$ strips had a goodinter-strip insulation with low values of p-spray and p-stop dopingdensities which is contrary to the expected behaviour from thecurrent understanding of radiation damage. In this work a simulationmodel has been devised incorporating radiation damage to understandand provide a possible explanation to the observed behaviour ofirradiated sensors.

Gloss, colour and grip: multifunctional epidermal cell shapes in bee- and bird-pollinated flowers.

Science.gov (United States)

Papiorek, Sarah; Junker, Robert R; Lunau, Klaus

2014-01-01

Flowers bear the function of filters supporting the attraction of pollinators as well as the deterrence of floral antagonists. The effect of epidermal cell shape on the visual display and tactile properties of flowers has been evaluated only recently. In this study we quantitatively measured epidermal cell shape, gloss and spectral reflectance of flowers pollinated by either bees or birds testing three hypotheses: The first two hypotheses imply that bee-pollinated flowers might benefit from rough surfaces on visually-active parts produced by conical epidermal cells, as they may enhance the colour signal of flowers as well as the grip on flowers for bees. In contrast, bird-pollinated flowers might benefit from flat surfaces produced by flat epidermal cells, by avoiding frequent visitation from non-pollinating bees due to a reduced colour signal, as birds do not rely on specific colour parameters while foraging. Moreover, flat petal surfaces in bird-pollinated flowers may hamper grip for bees that do not touch anthers and stigmas while consuming nectar and thus, are considered as nectar thieves. Beside this, the third hypothesis implies that those flower parts which are vulnerable to nectar robbing of bee- as well as bird-pollinated flowers benefit from flat epidermal cells, hampering grip for nectar robbing bees. Our comparative data show in fact that conical epidermal cells are restricted to visually-active parts of bee-pollinated flowers, whereas robbing-sensitive parts of bee-pollinated as well as the entire floral surface of bird-pollinated flowers possess on average flat epidermal cells. However, direct correlations between epidermal cell shape and colour parameters have not been found. Our results together with published experimental studies show that epidermal cell shape as a largely neglected flower trait might act as an important feature in pollinator attraction and avoidance of antagonists, and thus may contribute to the partitioning of flower-visitors.

Gloss, colour and grip: multifunctional epidermal cell shapes in bee- and bird-pollinated flowers.

Directory of Open Access Journals (Sweden)

Sarah Papiorek

Full Text Available Flowers bear the function of filters supporting the attraction of pollinators as well as the deterrence of floral antagonists. The effect of epidermal cell shape on the visual display and tactile properties of flowers has been evaluated only recently. In this study we quantitatively measured epidermal cell shape, gloss and spectral reflectance of flowers pollinated by either bees or birds testing three hypotheses: The first two hypotheses imply that bee-pollinated flowers might benefit from rough surfaces on visually-active parts produced by conical epidermal cells, as they may enhance the colour signal of flowers as well as the grip on flowers for bees. In contrast, bird-pollinated flowers might benefit from flat surfaces produced by flat epidermal cells, by avoiding frequent visitation from non-pollinating bees due to a reduced colour signal, as birds do not rely on specific colour parameters while foraging. Moreover, flat petal surfaces in bird-pollinated flowers may hamper grip for bees that do not touch anthers and stigmas while consuming nectar and thus, are considered as nectar thieves. Beside this, the third hypothesis implies that those flower parts which are vulnerable to nectar robbing of bee- as well as bird-pollinated flowers benefit from flat epidermal cells, hampering grip for nectar robbing bees. Our comparative data show in fact that conical epidermal cells are restricted to visually-active parts of bee-pollinated flowers, whereas robbing-sensitive parts of bee-pollinated as well as the entire floral surface of bird-pollinated flowers possess on average flat epidermal cells. However, direct correlations between epidermal cell shape and colour parameters have not been found. Our results together with published experimental studies show that epidermal cell shape as a largely neglected flower trait might act as an important feature in pollinator attraction and avoidance of antagonists, and thus may contribute to the partitioning of

Induction heating in in-line strip production process

International Nuclear Information System (INIS)

Costa, P.; Santinelli, M.

1995-05-01

ISP (In-line Strip Production), a continuous process for steel strip production, has recently been set in an italian innovative plant, where ecological impact and power requirements are lighter than usual. This report describes the studies performed by ENEA (Italian Agency for New Technologies, Energy and the Environment), while a prototype reheating facility was arranged by Acciaieria ISP in Cremona (Italy). The authors, after a study of the prototype electromagnetic field, calculate the heating rate, with the thermal network method. Then they detect, with a 1-D-FEM, the heat diffusion through the strip cross section. Afterward, since the heat distribution depends on the eddy current density one, which is given by the magnetic field distribution, the authors, with a 3-D-FEM, carry out a coupled, electromagnetic and thermal, analysis in time domain. The strip temperature map is established by the balance between skin depth heating and surface cooling: a thermal analysis, performed with a moving 2-D-FEM, take into account the effects of the different heating and cooling situations, originated by the strip moving at a speed of 6m/min through four consecutive reheating facilities. The temperatures of a strip sample heated by the prototype have been monitored, acquired by a computer and related with the simulation results. The little difference between experiment and simulation assessed the qualitative and quantitative validity of this analysis, that has come out to be a tool, useful to evaluate the effects of possible improvements to the ISP process

Micromorphology and development of the epicuticular structure on the epidermal cell of ginseng leaves

Directory of Open Access Journals (Sweden)

Kyounghwan Lee

2015-04-01

Conclusion: The outwardly projected cuticle and epidermal cell wall (i.e., an epicuticular wrinkle acts as a major barrier to block out sunlight in ginseng leaves. The small vesicles in the peripheral region of epidermal cells may suppress the cuticle and parts of epidermal wall, push it upward, and consequently contribute to the formation of the epicuticular structure.

Analysis of 'Coma strip' galaxy redshift catalog

International Nuclear Information System (INIS)

Klypin, A.A.; Karachentsev, I.D.; Lebedev, V.S.

1990-01-01

We present results of the analysis of a galaxy redshift catalog made at the 6-m telescope by Karachentsev and Kopylov (1990. Mon. Not. R. astr. Soc., 243, 390). The catalog covers a long narrow strip on the sky (10 arcmin by 63 0 ) and lists 283 galaxies up to limiting blue magnitude m B = 17.6. The strip goes through the core of Coma cluster and this is called the 'Coma strip' catalog. The catalog is almost two times deeper than the CfA redshift survey and creates the possibility of studying the galaxy distribution on scales of 100-250 Mpc. Due to the small number of galaxies in the catalog, we were able to estimate only very general and stable parameters of the distribution. (author)

31 CFR 356.31 - How does the STRIPS program work?

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false How does the STRIPS program work? 356.31 Section 356.31 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued...) Miscellaneous Provisions § 356.31 How does the STRIPS program work? (a) General. Notes or bonds may be “stripped...

Using Comic Strips as a Book Report Alternative

Science.gov (United States)

Reading Teacher, 2012

2012-01-01

Comic strips are great to share with parents, younger students, and peers. This article presents an activity where students use a six-paneled comic strip to summarize a story. This activity allows for multiple interpretations and enhances comprehension by drawing attention to story elements.

Possible role of epidermal keratinocytes in the construction of acupuncture meridians.

Science.gov (United States)

Denda, Mitsuhiro; Tsutsumi, Moe

2014-04-01

Acupuncture meridians consist of a network of acupuncture points on the skin, stimulation of which is well established to have a variety of physiological effects. We have previously demonstrated that epidermal keratinocytes contain multiple sensory systems for temperature, mechanical stimuli, electric potentials and other stimuli. These sensory systems generate changes in the calcium-ion concentration in the epidermis, so epidermal keratinocytes can generate spatially-localized electro-physiological patterns in the skin. We have previously demonstrated signaling between epidermal keratinocytes and peripheral nerve systems. Therefore, stimuli sensed by epidermal keratinocytes might be transferred to the unmyelinated nerve fibers that are known to exist in the epidermis and, thence, to the spinal cord and brain. We propose that epidermal keratinocytes form an information-gathering network in the skin and that this network plays a key role in whole-body homeostasis in response to the changing environment. We also hypothesize that this network corresponds to the acupuncture meridians. As supporting examples, we present some striking calcium propagation patterns observed in cultured human keratinocytes after adenosine-triphosphate (ATP) stimulation. These results support the ideas that keratinocytes can generate spatially-restricted signaling patterns after environmental stimulation and that the cultures might be in-vitro models of meridians as an information-gathering network in skin. Copyright © 2014. Published by Elsevier B.V.

Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells

International Nuclear Information System (INIS)

Jia Liwei; Zhou Jiaxi; Peng Sha; Li Juxue; Cao Yujing; Duan Enkui

2008-01-01

Epidermal stem cells maintain development and homeostasis of mammalian epidermis throughout life. However, the molecular mechanisms involved in the proliferation and differentiation of epidermal stem cells are far from clear. In this study, we investigated the effects of Wnt3a and Wnt/β-catenin signaling on proliferation and differentiation of human fetal epidermal stem cells. We found both Wnt3a and active β-catenin, two key members of the Wnt/β-catenin signaling, were expressed in human fetal epidermis and epidermal stem cells. In addition, Wnt3a protein can promote proliferation and inhibit differentiation of epidermal stem cells in vitro culture. Our results suggest that Wnt/β-catenin signaling plays important roles in human fetal skin development and homeostasis, which also provide new insights on the molecular mechanisms of oncogenesis in human epidermis

Magnetic ring for stripping enhancement

International Nuclear Information System (INIS)

Selph, F.

1992-10-01

A ring designed to recycle ions through a stripping medium offers the possibility for increasing output of the desired charge state by up to 4x. This could be a very important component of a Radioactive Nuclear Beam Facility. In order for such a ring to work effectively it must satisfy certain design conditions. These include achromaticity at the stripper, a dispersed region for an extraction magnet, and a number of first and higher order optics constraints which are necessary to insure that the beam emittance is not degraded unduly by the ring. An example is given of a candidate design of a stripping ring

The Epidermal Growth Factor Receptor Is a Regulator of Epidermal Complement Component Expression and Complement Activation

DEFF Research Database (Denmark)

Abu-Humaidan, Anas H A; Ananthoju, Nageshwar; Mohanty, Tirthankar

2014-01-01

The complement system is activated in response to tissue injury. During wound healing, complement activation seems beneficial in acute wounds but may be detrimental in chronic wounds. We found that the epidermal expression of many complement components was only increased to a minor extent in skin...

Do repeated rumble strip hits improve driver alertness?

NARCIS (Netherlands)

Watling, C.N.; Akerstedt, T.; Kecklund, L.G.; Anund, A.

2016-01-01

Driving while sleepy is associated with increased crash risk. Rumble strips are designed to alert a sleepy or inattentive driver when they deviate outside their driving lane. The current study sought to examine the effects of repeated rumble strip hits on levels of physiological and subjective

[Enhanced lymphocyte proliferation in the presence of epidermal cells of HIV-infected patients in vitro].

Science.gov (United States)

Kappus, R P; Berger, S; Thomas, C A; Ottmann, O G; Ganser, A; Stille, W; Shah, P M

1992-07-01

Clinical observations show that the HIV infection is often associated with affections of the skin. In order to examine the involvement of the epidermal immune system in the HIV infection, we determined accessory cell function of epidermal cells from HIV-1-infected patients. For this we measured the proliferative response of enriched CD(4+)-T-lymphocytes from HIV-infected patients and noninfected controls to stimulation with anti-CD3 and IL-2 in the presence of epidermal cells; the enhancement of the response is dependent on the presence of functionally intact accessory cells. The capacity of epidermal cells to increase the anti-CD3-stimulated T-cell proliferative response was significantly enhanced in HIV patients (CDC III/IVA) as compared with noninfected donors. It is discussed, whether the increased activity of epidermal cells from HIV-infected patients may be responsible for several of the dermal lesions in the course of an HIV infection as due to an enhanced production and release of epidermal cell-derived cytokines.

Epidermal Growth Factor and Intestinal Barrier Function

Directory of Open Access Journals (Sweden)

Xiaopeng Tang

2016-01-01

Full Text Available Epidermal growth factor (EGF is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health.

Evaluation of anatomy comic strips for further production and applications

Science.gov (United States)

Shin, Dong Sun; Kim, Dae Hyun; Park, Jin Seo; Jang, Hae Gwon

2013-01-01

The corresponding author of the study has been sketching comic strips to explain anatomy in a humorous manner. All the anatomy comic strips, including those in Korean (650 episodes) and English (451 episodes), can be viewed on the homepage (http://anatomy.co.kr). Such comic strips were created with the aim of assisting medical students. However, their impact was unknown, and therefore, we surveyed the students' responses. We noted that anatomy grades were better in the students who read the comic strips. The comics helped the trainees chat with individuals with and without a medical background. The authors also considered comments on the problems with the comic strips and attempted to find solutions. The episodes are being currently used and further produced for educational purposes. To support this effort, the readers' valuable opinions will be continuously collected and assessed. PMID:24179697

Evaluation of anatomy comic strips for further production and applications.

Science.gov (United States)

Shin, Dong Sun; Kim, Dae Hyun; Park, Jin Seo; Jang, Hae Gwon; Chung, Min Suk

2013-09-01

The corresponding author of the study has been sketching comic strips to explain anatomy in a humorous manner. All the anatomy comic strips, including those in Korean (650 episodes) and English (451 episodes), can be viewed on the homepage (http://anatomy.co.kr). Such comic strips were created with the aim of assisting medical students. However, their impact was unknown, and therefore, we surveyed the students' responses. We noted that anatomy grades were better in the students who read the comic strips. The comics helped the trainees chat with individuals with and without a medical background. The authors also considered comments on the problems with the comic strips and attempted to find solutions. The episodes are being currently used and further produced for educational purposes. To support this effort, the readers' valuable opinions will be continuously collected and assessed.

The charge collection in silicon strip detectors

International Nuclear Information System (INIS)

Boehringer, T.; Hubbeling, L.; Weilhammer, P.; Kemmer, J.; Koetz, U.; Riebesell, M.; Belau, E.; Klanner, R.; Lutz, G.; Neugebauer, E.; Seebrunner, H.J.; Wylie, A.

1983-02-01

The charge collection in silicon detectors has been studied, by measuring the response to high-energy particles of a 20μm pitch strip detector as a function of applied voltage and magnetic field. The results are well described by a simple model. The model is used to predict the spatial resolution of silicon strip detectors and to propose a detector with optimized spatial resolution. (orig.)

Perforator Flaps after Excision of Large Epidermal Cysts in the Buttocks

Directory of Open Access Journals (Sweden)

Sang Wha Kim

2014-03-01

Full Text Available Background Epidermal cysts are commonly occurring masses usually less than 5 cm in diameter, but in predisposed patients, epidermal cysts can grow relatively large due to chronic infection. Methods From June 2002 to July 2010, 17 patients received 19 regional perforator-based island flaps to cover defects due to the excision of large epidermal cysts (diameter >5 cm in the buttocks. Eight patients had diabetes, and seven had rheumatoid arthritis. The pedicles were not fully isolated to prevent spasms or twisting. Results All the flaps survived completely, except for one case with partial necrosis of the flap, which necessitated another perforator-based island flap for coverage. There were two cases of wound dehiscence, which were re-closed after meticulous debridement. There were no recurrences of the masses during follow-up periods of 8.1 months (range, 6-12 months. Conclusions In patients with large epidermal cysts and underlying medical disorders, regional perforator-based island flaps can be the solution to coverage of the defects after excision.

Refuges, flower strips, biodiversity and agronomic interest.

Science.gov (United States)

Roy, Grégory; Wateau, Karine; Legrand, Mickaël; Oste, Sandrine

2008-01-01

Several arthropods are natural predators of pests, and they are able to reduce and control their population development. FREDON Nord Pas-de-Calais (Federation Regionate de Defense contre les Organismes Nuisibles = Regional Federation for Pest Control) has begun for a long time to form farmers to the recognition of beneficial arthropods and to show them their usefulness. These beneficial insects or arachnids are present everywhere, in orchards and even in fields which are areas relatively poor in biodiversity. Adults feed in the flower strips instead larvae and some adults feed on preys such as aphids or caterpillars. Most of the time, beneficial insects can regulate pest but sometimes, in agricultural area, they can't make it early enough and efficiently. Their action begin too late and there biodiversity and number are too low. It's possible to enhance their action by manipulating the ecological infrastructures, like sewing flower strips or installing refuges. Flower strips increase the density of natural enemies and make them be present earlier in the field in order to control pests. Refuges permit beneficial's to spend winter on the spot. So they're able to be active and to grow in number earlier. From 2004 to 2007, on the one hand, FREDON Nord Pas-de-Calais has developed a research program. Its purpose was to inventory practices and also tools and means available and to judge the advisability of using such or such beneficial refuge in orchards. On the second hand, it studied the impact in orchard of refuges on population of beneficial's and the difference there were between manufactured refuges and homemade refuges. Interesting prospects were obtained with some of them. Otherwise, since 2003, FREDON has studied flower strips influence on beneficial population and their impact on pest control. In cabbage fields, results of trials have shown that flower strips lead to a reduction of aphid number under acceptable economic level, up to 50 meters from flower strips

Optimization of the process of steel strip perforation and nickel platting for the purpose of elimination of trichloroethylene from the cleaning process of perforated steel strip

Directory of Open Access Journals (Sweden)

Petrović Aleksandra B.

2009-01-01

Full Text Available In the production of pocket type electrodes for Ni-Cd batteries perforation of proper steel strips and then nickel platting of perforated steel strips were made. In the nickel platting process, the organic solvent, trichloroethylene, has previously been used for cleaning. Due to the carcinogenic nature of trichloroethylene and the many operations previously required during cleaning, it was considered to do cleaning of perforated steel strips without use of the mentioned organic solvent. In the purpose of elimination of trichloroethylene from the cleaning process of perforated steel strips, the tests of perforation of steel strips with use of oils of different viscosity were made. It was shown that there was no dysfunction during the work of the perforation plants, meaning there was no additional heating of the strips, deterring of the steel filings, nor excessive wearing of the perforation apparatus. The perforation percent was the same irrelevant of the viscosity of the used oil. Before being perforated using the oils with different viscosity, the nickel platting steel strips were cleaned in different degreasers (based on NaOH as well as on KOH. It was shown that efficient cleaning without the use of trichloroethylene is possible with the use of oil with smaller viscosity in the perforated steel strips process and the degreaser based on KOH in the cleaning process, before nickel platting. It also appeared that the alkali degreaser based on KOH was more efficient, bath corrections were made less often and the working period of the baths was longer, which all in summary means less quantity of chemicals needed for degreasing of perforated steel strips.

Commonly Employed African Neonatal Skin Care Products Compromise Epidermal Function in Mice.

Science.gov (United States)

Man, Mao-Qiang; Sun, Richard; Man, George; Lee, Dale; Hill, Zelee; Elias, Peter M

2016-09-01

Neonatal mortality is much higher in the developing world than in developed countries. Infections are a major cause of neonatal death, particularly in preterm infants, in whom defective epidermal permeability barrier function facilitates transcutaneous pathogen invasion. The objective was to determine whether neonatal skin care products commonly used in Africa benefit or compromise epidermal functions in murine skin. After twice-daily treatment of 6- to 8-week-old hairless mice with each skin care product for 3 days, epidermal permeability barrier function, skin surface pH, stratum corneum hydration, and barrier recovery were measured using a multiprobe adapter system physiology monitor. For products showing some benefits in these initial tests, the epidermal permeability barrier homeostasis was assessed 1 and 5 hours after a single application to acutely disrupted skin. All of the skin care products compromised basal permeability barrier function and barrier repair kinetics. Moreover, after 3 days of treatment, most of the products also reduced stratum corneum hydration while elevating skin surface pH to abnormal levels. Some neonatal skin care products that are widely used in Africa perturb important epidermal functions, including permeability barrier homeostasis in mice. Should these products have similar effects on newborn human skin, they could cause a defective epidermal permeability barrier, which can increase body fluid loss, impair thermoregulation, and contribute to the high rates of neonatal morbidity and mortality seen in Africa. Accordingly, alternative products that enhance permeability barrier function should be identified, particularly for use in preterm infants. © 2016 Wiley Periodicals, Inc.

Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age

Directory of Open Access Journals (Sweden)

Zobiri O

2012-02-01

Full Text Available Olivia Zobiri, Nathalie Deshayes, Michelle Rathman-JosserandDepartment of Biological Research, L'Oréal Advanced Research, Clichy Cedex, FranceAbstract: A number of clinical observations have indicated that the regenerative potential and overall function of the epidermis is modified with age. The epidermis becomes thinner, repairs itself less efficiently after wounding, and presents modified barrier function recovery. In addition, the dermal papillae flatten out with increasing age, suggesting a modification in the interaction between epidermal and dermal compartments. As the epidermal regenerative capacity is dependent upon stem and progenitor cell function, it is naturally of interest to identify and understand age-related changes in these particular keratinocyte populations. Previous studies have indicated that the number of stem cells does not decrease with age in mouse models but little solid evidence is currently available concerning human skin. The objective of this study was to evaluate the clonogenic potential of keratinocyte populations isolated from the epidermis of over 50 human donors ranging from 18 to 71 years old. The data indicate that the number of epidermal cells presenting high regenerative potential does not dramatically decline with age in human skin. The authors believe that changes in the microenvironment controlling epidermal basal cell activity are more likely to explain the differences in epidermal function observed with increasing age.Keywords: skin, epidermal stem cells, aging, colony-forming efficiency test

Polymer Inclusion Membranes with Strip Dispersion

Directory of Open Access Journals (Sweden)

Yueh-Hsien Li

2017-06-01

Full Text Available The present work investigated the permeation of indium ions through a polymer inclusion membrane (PIM, prepared with cellulose triacetate (CTA as the base polymer, tris(2-butoxyethyl phosphate (TBEP as the plasticizer and di-(2-ethylhexylphosphoric acid (D2EHPA as the extractant. With 5 M HCl aqueous solution as the strip solution, we observed an initial indium permeability of 2.4 × 10−4 m/min. However, the permeability decreases with time, dropping to about 3.4 × 10−5 m/min after 200 min of operation. Evidence was obtained showing that hydrolysis of CTA occurred, causing a dramatic decrease in the feed pH (protons transported from strip to feed solutions and a loss of extractant and plasticizer from the membrane, and then leading to the loss of indium permeability. To alleviate the problem of hydrolysis, we proposed an operation scheme called polymer inclusion membranes with strip dispersion: dispersing the strip solution in extractant-containing oil and then bringing the dispersion to contact with the polymer membrane. Since the strong acid was dispersed in oil, the membrane did not directly contact the strong acid at all times, and membrane hydrolysis was thus alleviated and the loss of indium permeability was effectively prevented. With the proposed scheme, a stable indium permeability of 2.5 × 10−4 m/min was obtained during the whole time period of the permeation experiment.

Validity of HydraTrend reagent strips for the assessment of hydration status.

Science.gov (United States)

Abbey, Bryce M; Heelan, Kate A; Brown, Gregory A; Bartee, Rodrick T

2014-09-01

Hydration is used by athletic governing organizations for weight class eligibility. The measurement of urine specific gravity (USG) as a measure of hydration by reagent strips is a controversial issue. The purpose of this study was to determine the validity of HydraTrend reagent strips that facilitate the correction of USG for alkaline urine samples against refractometry for the assessment of USG. Fifty-one participants (33 males, age = 22.3 ± 1.3 years; 18 females, age = 22.4 ± 1.2 years) provided 84 urine samples. The samples were tested for USG using refractometry and reagent strips and for pH using reagent strips and a digital pH meter. Strong correlation coefficients were found between refractometry and reagent strips for USG (rs(82) = 0.812, p refractometry with USG >1.020, pass reagent strips with USG ≤1.020) occurred 39% (33/84) of the time and false negative results for National Federation of State High School Association (NFHS) requirements (fail refractometry with USG >1.025, pass reagent strips with USG ≤1.025) occurred 14% (12/84) of the time. There were no false positives (pass refractometry and fail reagent strips) for NCAA or NFHS requirements. These data show that refractometry and reagent strips have strong positive correlations. However, the risk of a false negative result leading to incorrect certification of euhydration status outweighs the benefits of the HydraTrend reagent strips for the measurement of USG.

Significance of wave form parameters in stripping chronopotentiometric metal speciation analysis

NARCIS (Netherlands)

Town, R.M.; Leeuwen, van H.P.

2002-01-01

An analysis is presented of the significance of stripping chronopotentiometric (SCP) stripping peak parameters (peak potential, Ep, and peak half-width, w1/2) for determination of metal ion speciation. This study focuses on depletive SCP (low stripping current, I¿ constant), and considers the change

Electrode/Dielectric Strip For High-Energy-Density Capacitor

Science.gov (United States)

Yen, Shiao-Ping S.

1994-01-01

Improved unitary electrode/dielectric strip serves as winding in high-energy-density capacitor in pulsed power supply. Offers combination of qualities essential for high energy density: high permittivity of dielectric layers, thinness, and high resistance to breakdown of dielectric at high electric fields. Capacitors with strip material not impregnated with liquid.

Strip reduction testing of lubricants developed during ENFORM project

DEFF Research Database (Denmark)

Gazvoda, S.; Andreasen, Jan Lasson; Olsson, David Dam

Strip reduction testing of lubricants developed during ENFORM project. Experiments were conducted with the strip reduction test [1] in order to classify experimental lubricants, developed during concerned project. One reference lubricant was used during testing....

Micro-strip Metal Foil Detectors for the Beam Profile Monitoring

CERN Document Server

Pugatch, V M; Fedorovitch, O A; Mikhailenko, A V; Prystupa, S V; Pylypchenko, Y

2005-01-01

The Micro-strip Metal Foil Detectors (MMFD) designed and used for the Beam Profile Monitoring (BPM) are discussed. Fast particles hitting a metal strip initiate Secondary Electron Emission (SEE) which occurs at 10 - 50 nm surface layers of a strip. The SEE yield is measured by a sensitive Charge Integrator with built-in current-to-frequency converter (1 Hz per 1 fA). The MMFD (deposited onto the 20 μm thick Si-wafer) with 32 Al strips (10 μm wide, 32 μm pitch) has been used for the BPM of the 32 MeV alpha-particle beam at the MPIfK (Heidelberg) Tandem generator for Single-Event-Upset studies of the BEETLE micro-chip. Similar MMFD (0.5 μm thick Ni-strips) with totally removed Si-wafer (by plasma-chemistry, at the working area of 8 x 10 mm2) has been applied for the on-line X-ray BPM at the HASYLAB (DESY). The number of photons (11.3 GeV, mean X-ray energy 18 keV) producing out of a strip a single SEE was evaluated as (1.5 ±0.5)* 104. MMFD has demonstrated stable...

Caracterização morfoanatômica das folhas de Eremanthus erythropappus (DC. MacLeisch, Asteraceae Leaf morpho-anatomical characterization of Eremanthus erythropappus (DC. MacLeisch, Asteraceae

Directory of Open Access Journals (Sweden)

Rafael C. Dutra

2010-12-01

Full Text Available Eremanthus erythropappus (DC. MacLeisch (Asteraceae, popularmente conhecida como "candeia-da-serra", é uma espécie utilizada na medicina tradicional como cicatrizante e antimicrobiano. O objetivo do presente trabalho foi comparar o número de tricomas glandulares nas folhas jovens e adultas de E. erythropappus, assim como realizar a caracterização morfoanatômica destas folhas. Secções transversais e paradérmicas das folhas foram submetidas às microtécnicas fotônicas e à microscopia eletrônica de varredura. A quantificação dos tricomas glandulares foi realizada em folhas jovens e adultas com auxílio de câmara clara. As folhas são alternas ou fasciculadas e a lâmina foliar possui epiderme uniestratificada, revestida por cutícula delgada e lisa e mesofilo dorsiventral. Em ambas as faces da epiderme, ocorrem estômatos predominantemente anomocíticos e tricomas glandulares inseridos em depressões. Na face abaxial observam-se numerosos tricomas tectores. O parênquima paliçádico é uniestratificado e o parênquima voltado para a face abaxial é formado por três a cinco camadas de células com disposição compacta. As folhas jovens e adultas apresentam respectivamente 21,78±5,83 e 17,80±6,69 tricomas glandulares na face adaxial. A análise morfoanatômica das folhas de E. erythropappus mostra-se um método rápido e prático para a identificação e controle de qualidade de espécies vegetais utilizadas na terapêutica.Eremanthus erythropappus (DC. MacLeisch (Asteraceae, commonly known as 'candeia-da-serra', is a plant used in folk medicine as wound healing and antimicrobial. The aim of this study was to compare the number of glandular trichomes between the young and the mature leaves, as well as to perform the morpho-anatomical characterization of E. erythropappus leaves. Transverse and paradermal sections of the leaves were prepared according to light and scanning microtechniques for the morpho-anatomical characterization

Inhibition of epidermal cell proliferation by borderline rays

Energy Technology Data Exchange (ETDEWEB)

Born, W [Freiburg Univ.; Daikeler, G

1976-08-01

Treatment of guinea pig flanks with very soft x-rays (borderline rays) directly caused a partial block of epidermal DNA synthesis which had been determined by measuring the /sup 3/H-Tdr incorporation. Higher doses and repeated applications would undoubtedly cause lasting damage to the tissue. The enhanced epidermal DNA synthesis which is sometimes observed should not be misinterpreted as a sign of a directly biopositive utilisation of the quantum energy supplied. Rather, it is a secondary repair process following initial phases of depression. A reparative increase in DNA synthesis may also occur as a primary process if the radiation is almost completely absorbed above the germinative layer.

Removal of nitrogen from swine manure by ammonia stripping; Reduccion del contenido en nitrogeno amoniacal del purin procino mediante la tecnica de stripping

Energy Technology Data Exchange (ETDEWEB)

Hidalgo, M. D.; Alamo, J. del; Nunez, U.; Irusta, R. [Grupo de Tecnologia Ambiental . Laboratorio de Analisis y Estudios Medioambientales. Valladolid (Spain)

2001-07-01

Lab scale experiments were undertaken to investigate air stripping as method for removing ammonia from cattle effluents and, more concretely, from the liquid fraction of swine manure. The effects of packet size, influent pH, air to liquid flow ratio and liquid recirculation flow in the stripping tower were investigated. The high ammonia removal efficiency of the air stripping method indicates that it could provide an interim solution for current waste management problems in the swine industry. (Author) 5 refs.

Flexible strip supercapacitors for future energy storage

OpenAIRE

Zhang, R-R; Xu, Y-M; Harrison, D; Fyson, J; Qiu, F-L; Southee, D

2015-01-01

Flexible strip supercapacitors are developed and their electrochemical properties are characterized. Activated carbon is used as the electrode material and it is found to have a good porous structure which provides a large surface area for energy storage. Furthermore, this activated carbon performs well. The manufacturing processes for the supercapacitors are described in detail and the preparation process has good reproducibility. The strip supercapacitors are combined in series and parallel...

Comparative characteristics of polystyrene scintillation strips

International Nuclear Information System (INIS)

Gapienko, V.A.; Denisov, A.G.; Mel'nikov, E.A.

1992-01-01

Results are provided for a study of the main characteristics of polystyrene scintillation strips with a cross-section of 200 x 10 mm with two different scintillation-additive compositions: 1.5% p-terphenyl + 0.01% POPOP and 1.5% p-terphenyl + 0.01% DBP. The mean light-attenuation lengths are 180 cm and 260 cm, respectively, for strips with POPOP and DBP. The emittances of the polystyrene scintillators with DBP and POPOP additives have a ratio of 0.8:1.0 as recorded by an FEU-110 photomultiplier. 2 refs., 1 fig., 2 tabs

Study the Z-Plane Strip Capacitance

International Nuclear Information System (INIS)

Parikh, H.; Swain, S.

2005-01-01

The BaBaR detector at the Stanford Linear Accelerator Center is currently undergoing an upgrade to improve its muon and neutral hadron detection system. The Resistive Plate Chambers (RPCs) that had been used till now have deteriorated in performance over the past few years and are being replaced by Limited Streamer Tube (LSTs). Each layer of the system consists of a set of up to 10 streamer tube modules which provide one coordinate (φ coordinate) and a single ''Z-plane'' which provides the Z coordinate of the hit. The large area Z-planes (up to 12m 2 ) are 1mm thick and contain 96 copper strips that detect the induced charge from avalanches created in the streamer tube wires. All the Z-planes needed for the upgrade have already been constructed, but only a third of the planes were installed last summer. After installing the 24 Z-planes last year, it was learned that 0.7% of the strips were dead when put inside the detector. This was mainly due to the delicate solder joint between the read-out cable and the strip, and since it is difficult to access or replace the Z-planes inside the detector, it is very important to perform various tests to make sure that the Z-planes will be efficient and effective in the long term. We measure the capacitance between the copper strips and the ground plane, and compare it to the theoretical value that we expect. Instead of measuring the capacitance channel by channel, which would be a very tedious job, we developed a more effective method of measuring the capacitance. Since all the Z-planes were built at SLAC, we also built a smaller 46 cm by 30 cm Z-plane with 12 strips just to see how they were constructed and to gain a better understanding about the solder joints

Effects of hydrostatic strain on eigenstates of Möbius strips

DEFF Research Database (Denmark)

Lassen, Benny; Willatzen, Morten; Gravesen, Jens

2011-01-01

In this paper we theoretically investigate the allowed energies and associate wave-functions for Möbius strips with varying thicknesses. We show that the induced strain in fabricating these Möbius strips will have an pronounced impact on the energies and wave-functions for thick strips, while f...... for thin strips the impact of strain is negligible. We furthermore, show that a simpler strain free approximate theory base on differential geometry is in excellent agreement with detailed finite element calculations. © 2011 IEEE....

Low-resistance strip sensors for beam-loss event protection

International Nuclear Information System (INIS)

Ullán, M.; Benítez, V.; Quirion, D.; Zabala, M.; Pellegrini, G.; Lozano, M.; Lacasta, C.; Soldevila, U.; García, C.; Fadeyev, V.; Wortman, J.; DeFilippis, J.; Shumko, M.; Grillo, A.A; Sadrozinski, H.F.-W.

2014-01-01

AC-coupled silicon strip sensors can be damaged in case of a beam loss due to the possibility of a large charge accumulation in the bulk, developing very high voltages across the coupling capacitors which can destroy them. Punch-through structures are currently used to avoid this problem helping to evacuate the accumulated charge as large voltages are developing. Nevertheless, previous experiments, performed with laser pulses, have shown that these structures can become ineffective in relatively long strips. The large value of the implant resistance can effectively isolate the “far” end of the strip from the punch-through structure leading to large voltages. We present here our developments to fabricate low-resistance strip sensors to avoid this problem. The deposition of a conducting material in contact with the implants drastically reduces the strip resistance, assuring the effectiveness of the punch-through structures. First devices have been fabricated with this new technology. Initial results with laser tests show the expected reduction in peak voltages on the low resistivity implants. Other aspects of the sensor performance, including the signal formation, are not affected by the new technology

Silicon strip detector qualification for the CMS experiment

Energy Technology Data Exchange (ETDEWEB)

Kaussen, Gordon

2008-10-06

To provide the best spatial resolution for the particle trajectory reconstruction and a very fast readout, the inner tracking system of CMS is build up of silicon detectors with a pixel tracker in the center surrounded by a strip tracker. The silicon strip tracker consists of so-called modules representing the smallest detection unit of the tracking device. These modules are mounted on higher-level structures called shells in the tracker inner barrel (TIB), rods in the tracker outer barrel (TOB), disks in the tracker inner disks (TID) and petals in the tracker end caps (TEC). The performance of the participating two shells of the TIB, four rods of the TOB and two petals of the TEC (representing about 1% of the final strip tracker) could be studied in different magnetic fields over a period of approximately two month using cosmic muon signals. The last test before inserting the tracker in the CMS experiment was the Tracker Slice Test performed in spring/summer 2007 at the Tracker Integration Facility (TIF) at CERN after installing all subdetectors in the tracker support tube. Approximately 25% of the strip tracker +z side was powered and read out using a cosmic ray trigger built up of scintillation counters. In total, about 5 million muon events were recorded under various operating conditions. These events together with results from commissioning runs were used to study the detector response like cluster charges, signal-to-noise ratios and single strip noise behaviour as well as to identify faulty channels which turned out to be in the order of a few per mille. The performance of the silicon strip tracker during these different construction stages is discussed in this thesis with a special emphasis on the tracker end caps. (orig.)

Silicon strip detector qualification for the CMS experiment

International Nuclear Information System (INIS)

Kaussen, Gordon

2008-01-01

To provide the best spatial resolution for the particle trajectory reconstruction and a very fast readout, the inner tracking system of CMS is build up of silicon detectors with a pixel tracker in the center surrounded by a strip tracker. The silicon strip tracker consists of so-called modules representing the smallest detection unit of the tracking device. These modules are mounted on higher-level structures called shells in the tracker inner barrel (TIB), rods in the tracker outer barrel (TOB), disks in the tracker inner disks (TID) and petals in the tracker end caps (TEC). The performance of the participating two shells of the TIB, four rods of the TOB and two petals of the TEC (representing about 1% of the final strip tracker) could be studied in different magnetic fields over a period of approximately two month using cosmic muon signals. The last test before inserting the tracker in the CMS experiment was the Tracker Slice Test performed in spring/summer 2007 at the Tracker Integration Facility (TIF) at CERN after installing all subdetectors in the tracker support tube. Approximately 25% of the strip tracker +z side was powered and read out using a cosmic ray trigger built up of scintillation counters. In total, about 5 million muon events were recorded under various operating conditions. These events together with results from commissioning runs were used to study the detector response like cluster charges, signal-to-noise ratios and single strip noise behaviour as well as to identify faulty channels which turned out to be in the order of a few per mille. The performance of the silicon strip tracker during these different construction stages is discussed in this thesis with a special emphasis on the tracker end caps. (orig.)

Giant epidermal inclusion cyst in the male breast: A case report

Energy Technology Data Exchange (ETDEWEB)

KIm, Hyun Jin; Park, Woon Ju; KIm, Sang Wook; Paik, So Ya [Daejin Medical Center Bundang Jesaeng General Hospital, Seongnam (Korea, Republic of)

2017-03-15

Giant epidermal inclusion cyst is a rare disease entity, and the occurrence of this cyst in the male breast is extremely rare. We report a case of giant epidermal inclusion cyst in the breast, which presented as a palpable and painful right breast mass in a 63-year-old man. The sonographic and computed tomography (CT) features are described in-depth. Physical examination revealed a firm, well-defined mass in the upper central portion of the right breast. Ultrasonography showed a 5.2 cm sized, oval, circumscribed, and complex cystic and solid mass with posterior acoustic enhancement, and CT showed a well-defined homogeneous low density mass without enhancement in the right breast. Surgical excision was performed, and pathological examination revealed a giant epidermal inclusion cyst.

Metal films with imprinted nanostructures by template stripping

DEFF Research Database (Denmark)

Eriksen, René Lynge; Pors, Anders; Dreier, Jes

We present a novel template stripping procedure for fabricating metal films with imprinted nanostructures. The basic idea is to deposit a gold film onto a nano-structured substrate and subsequently strip the film from the substrate surface thereby revealing imprinted nanostructures in the film...... result is a thin gold film with imprinted nano-cavities....

Liquidity, Reconstitution, and the Value of U.S. Treasury Strips.

OpenAIRE

Daves, Phillip R; Ehrhardt, Michael C

1993-01-01

An apparent pricing anomaly exists in the market for U.S. Treasury strips: zero-coupon strips created from principal payments typically trade at significantly higher prices than otherwi se identical zero-coupon strips created from coupon payments. In additi on to documenting this phenomenon, this study demonstrates that differences in liquidity and differences in reconstitution characteristics explain much of this price variation. Copyright 1993 by American Finance Association.

Deuteron stripping reactions with Tabakin potential

International Nuclear Information System (INIS)

Osman, A.

1976-05-01

Deuteron stripping reactions are considered. Due to the strong repulsion between nucleons at very short distances, we have investigated the nuclear short-range correlations. The neutron proton nuclear potential in the deuteron is taken as a short-range repulsive core surrounded by a long-range attractive potential. The neutron-proton potential is taken as the Tabakin separable potential to take into account the short-range correlations. The differential cross-sections for deuteron stripping reactions have been calculated in two different cases by taking Yamaguchi or Breit et al type parameters for the Tabakin potential used. The angular distributions for different (d,p) stripping reactions on the different target nuclei 28 Si, 32 , 34 S, 36 Ar, 40 , 48 Ca, 50 , 52 , 54 Cr have been calculated using the DWBA calculations. Our present theoretical calculations for the angular distributions of the different reactions cosidered have been fitted to the experimental data, where good agreement is obtained. The extracted spectroscopic factors from the present work are found to be more reliable

Precipitation stripping of neodymium from carboxylate extractant with aqueous oxalic acid solutions

International Nuclear Information System (INIS)

Konishi, Yasuhiro; Asai, Satoru; Murai, Tetuya

1993-01-01

This paper describes a precipitation stripping method in which neodymium ions are stripped from carboxylate extractant in organic solvent and simultaneously precipitated with aqueous oxalic acid solution. For the single-stage process, a quantitative criterion for precipitating oxalate powders was derived theoretically, and stripping experiments were done under the precipitation conditions. The resultant precipitates were neodymium oxalate, which is completely free from contamination by the carboxylate extractant and the organic solvent. The overall rate of stripping was controlled by the transfer of neodymium carboxylate in the organic solution, indicating that the presence of oxalic acid in the aqueous phase has no effect on the stripping rate. These findings demonstrate the feasibility of combining the conventional stripping and precipitation stages in a solvent extraction process for separation and purification of rare earths

Reforestation of strip-mined lands in West Virginia

Science.gov (United States)

H. Spencer Potter; Sidney Weitzman; George R., Jr. Trimble

1951-01-01

The early 1940's witnessed a striking increase in strip-mining throughout the eastern coal region. West Virginia, with its extensive coal resources, naturally was caught in the full current of this shift in mining methods. Today the raw gash on the hillside - almost infallibly the mark of a strip-mine operation - is a familiar sight in the State.

Stripping foils for the PSB H- injection system

CERN Document Server

Aiba, M; Goddard, B; Weterings, W

2009-01-01

Beam physics considerations for the stripping foil of the PSB H- injection system are described, including the arguments for the foil type, thickness, geometry and positioning. The foil performance considerations are described, including expected stripping efficiency, emittance growth, energy straggling, temperature and lifetime. The required movement ranges and tolerances are detailed, together with the assumptions used.

Quality Tests of Double-Sided Silicon Strip Detectors

CERN Document Server

Cambon, T; CERN. Geneva; Fintz, P; Guillaume, G; Jundt, F; Kuhn, C; Lutz, Jean Robert; Pagès, P; Pozdniakov, S; Rami, F; Sparavec, K; Dulinski, W; Arnold, L

1997-01-01

The quality of the SiO2 insulator (AC coupling between metal and implanted strips) of double-sided Silicon strip detectors has been studied by using a probe station. Some tests performed on 23 wafers are described and the results are discussed. Remark This note seems to cause problems with ghostview but it can be printed without any problem.

Evaluation of a portable urinary pH meter and reagent strips.

Science.gov (United States)

De Coninck, Vincent; Keller, Etienne Xavier; Rodríguez-Monsalve, María; Haymann, Jean-Philippe; Doizi, Steeve; Traxer, Olivier

2018-04-27

To evaluate a portable electronic pH meter and to put its accuracy in perspective with reagent strips read by a layperson, a healthcare professional and an electronic reading device. Based on a pre-analysis on 20 patients, a sample size of 77 urine aliquots from healthy volunteers was necessary to obtain sufficient study power. Measurements of urinary pH were obtained by use of reagent strips, a portable pH meter and a laboratory pH meter (gold standard). Reagents strips were read by a professional experienced in interpreting strips, a layperson, and an electronic strip reader. The mean matched pair difference between measurement methods was analyzed by the paired t-test. The degree of correlation and agreement were evaluated by the Pearson's correlation coefficient and Bland-Altman plots, respectively. The mean matched pair difference between the gold standard and all other pH measurement methods was the smallest with the portable electronic pH meter (bias 0.01, 95% CI -0.07 to 0.08; p=0.89), followed by strips read by a professional (bias -0.09, 95% CI -0.21 to 0.02; p=0.10), layperson (bias -0.17, 95% CI -0.31 to -0.04; p=0.015) and electronic strip reader (bias -0.29, 95% CI -0.41 to -0.16; pmeter achieved the highest Pearson's correlation coefficient and narrowest 95% limits of agreement, followed by strip interpretation by a professional, the electronic strip reader and the layperson. In order to quantify the ability of pH measurement methods to correctly classify values within a predefined urinary pH target range, we performed classification tests for several stones. The portable electronic pH meter outperformed all other measurement methods for negative predictive values. Findings of the current study support that the portable electronic pH meter is a reliable pH measuring device. It seems to be more accurate compared to reagent strips readings.

Micromorphological Studies of the Loranthaceae, Phragmanthera capitata (Sprengel Balle

Directory of Open Access Journals (Sweden)

Franklin Uangbaoje Ohikhena

2017-01-01

Full Text Available Phragmanthera capitata (Sprengel Balle is a mistletoe of the Loranthaceae family that has been explored for its therapeutic properties in folklore for ages. However, there had been an alarming increase in misidentification of species in this family. This may be due in part to the lack of species taxonomic information. Hence, this study wishes to highlight the range of micromorphological features which could complement the information database of this species. Scanning electron, light, and energy dispersive X-ray (EDX microscopies were used for this study. The result revealed a paracytic type of stomata with mean abaxial and adaxial density of 225.42±3.67 mm2 and 137.21±5.65 mm2, respectively, and mean guard cell length of 26.45±0.02 μm. Oval-shaped lenticels with a mean length of 34.29±0.26 μm were observed. They were arranged in parallel on the epidermal cells of the abaxial midrib. Densely packed stellate trichomes were revealed on the abaxial epidermis with a density of 63.32±3.70 mm2. Tracheary elements, which are tightly packed with granules believed to be proteins, were observed in the cross sections of the twig. Deposits chiefly composed of silicon, aluminium, potassium, and iron were recorded in the EDX analysis. This study revealed detailed descriptive micromorphological structures which could serve as a source of information and reference for the taxonomic description of P. capitata.

A new strips tracker for the upgraded ATLAS ITk detector

Science.gov (United States)

David, C.

2018-01-01

The ATLAS detector has been designed and developed to function in the environment of the present Large Hadron Collider (LHC). At the next-generation tracking detector proposed for the High Luminosity LHC (HL-LHC), the so-called ATLAS Phase-II Upgrade, the fluences and radiation levels will be higher by as much as a factor of ten. The new sub-detectors must thus be faster, of larger area, more segmented and more radiation hard while the amount of inactive material should be minimized and the power supply to the front-end systems should be increased. For those reasons, the current inner tracker of the ATLAS detector will be fully replaced by an all-silicon tracking system that consists of a pixel detector at small radius close to the beam line and a large area strip tracker surrounding it. This document gives an overview of the design of the strip inner tracker (Strip ITk) and summarises the intensive R&D activities performed over the last years by the numerous institutes within the Strips ITk collaboration. These studies are accompanied with a strong prototyping effort to contribute to the optimisation of the Strip ITk's structure and components. This effort culminated recently in the release of the ATLAS Strips ITk Technical Design Report (TDR).

Comparison of blood glucose test strips in the detection of neonatal hypoglycaemia

OpenAIRE

Wilkins, B H; Kalra, D

1982-01-01

Blood glucose levels were estimated in 101 neonatal blood samples using three glucose test strip methods and the results compared with those from a laboratory. BM-test-glycemie 20-800 test strips and Reflotest-hypoglycemie test strips gave a rapid and reliable estimate of blood glucose level in the range 0-8 mmol/l (0-140 mg/100 ml). Dextrostix test strips tended to overestimate all blood glucose levels.

Epidermal stem cells - role in normal, wounded and pathological psoriatic and cancer skin

DEFF Research Database (Denmark)

Kamstrup, M.; Faurschou, A.; Gniadecki, R.

2008-01-01

In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present...... or transit amplifying cells constitute a primary pathogenetic factor in the epidermal hyperproliferation seen in psoriasis. In cutaneous malignancies mounting evidence supports a stem cell origin in skin carcinoma and malignant melanoma and a possible existence of cancer stem cells Udgivelsesdato: 2008/5...

Buffers and vegetative filter strips

Science.gov (United States)

Matthew J. Helmers; Thomas M. Isenhart; Michael G. Dosskey; Seth M. Dabney

2008-01-01

This chapter describes the use of buffers and vegetative filter strips relative to water quality. In particular, we primarily discuss the herbaceous components of the following NRCS Conservation Practice Standards.

The depletion properties of silicon microstrip detectors with variable strip pitch

International Nuclear Information System (INIS)

Krizmanic, J.F.

1994-01-01

We have investigated the depletion properties of trapezoidal shaped silicon microstrip detectors which have variable strip pitch. Four types of detectors were examined: three detectors have constant strip width and a fourth has a varying strip width. The detectors are single sided with readout performed via p + strips. The depletion properties of the devices were measured using two different methods. The first used capacitance versus voltage measurements, while the second used a 1060 nm wavelength laser coupled to a single mode fiber with a mode field diameter less than 10 μm. The small laser spot size allowed for the depletion depth to be measured in a localized area of the detector. The laser induced charge on an electrode was measured as a function of reverse bias voltage using a sensitive charge preamplifier. The depletion voltages of the detectors demonstrate a strong dependence upon the ratio of strip width to strip pitch. Moreover, these measurements show that a large value of this ratio yields a lower depletion voltage and vice versa. (orig.)

A GEM readout with radial zigzag strips and linear charge-sharing response

Science.gov (United States)

Zhang, Aiwu; Hohlmann, Marcus; Azmoun, Babak; Purschke, Martin L.; Woody, Craig

2018-04-01

We study the position sensitivity of radial zigzag strips intended to read out large GEM detectors for tracking at future experiments. Zigzag strips can cover a readout area with fewer strips than regular straight strips while maintaining good spatial resolution. Consequently, they can reduce the number of required electronic channels and related cost for large-area GEM detector systems. A non-linear relation between incident particle position and hit position measured from charge sharing among zigzag strips was observed in a previous study. We significantly reduce this non-linearity by improving the interleaving of adjacent physical zigzag strips. Zigzag readout structures are implemented on PCBs and on a flexible foil and are tested using a 10 cm × 10 cm triple-GEM detector scanned with a strongly collimated X-ray gun on a 2D motorized stage. Angular resolutions of 60-84 μrad are achieved with a 1.37 mrad angular strip pitch at a radius of 784 mm. On a linear scale this corresponds to resolutions below 100 μm.

Epidermal CYP2 family cytochromes P450

International Nuclear Information System (INIS)

Du Liping; Hoffman, Susan M.G.; Keeney, Diane S.

2004-01-01

Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. Here, we review evidence for epidermal expression of genes from the large CYP2 gene family, many of which are expressed preferentially in extrahepatic tissues or specifically in epithelia at the environmental interface. At least 13 CYP2 genes (CYP2A6, 2A7, 2B6, 2C9, 2C18, 2C19, 2D6, 2E1, 2J2, 2R1, 2S1, 2U1, and 2W1) are expressed in skin from at least some human individuals, and the majority of these genes are expressed in epidermis or cultured keratinocytes. Where epidermal expression has been localized in situ by hybridization or immunocytochemistry, CYP2 transcripts and proteins are most often expressed in differentiated keratinocytes comprising the outer (suprabasal) cell layers of the epidermis and skin appendages. The tissue-specific transcriptional regulation of CYP2 genes in the epidermis, and in other epithelia that interface with the environment, suggests important roles for at least some CYP2 gene products in the production and disposition of molecules affecting competency of the epidermal barrier

Sediment removal by prairie filter strips in row-cropped ephemeral watersheds

Science.gov (United States)

Matthew J. Helmers; Xiaobo Zhou; Heidi Asbjornsen; Randy Kolka; Mark D. Tomer; Richard M. Cruse

2012-01-01

Twelve small watersheds in central Iowa were used to evaluate the eff ectiveness of prairie filter strips (PFS) in trapping sediment from agricultural runoff. Four treatments with PFS of different size and location (100% rowcrop, 10% PFS of total watershed area at footslope, 10% PFS at footslope and in contour strips, 20% PFS at footslope and in contour strips)...

Maturational steps of bone marrow-derived dendritic murine epidermal cells. Phenotypic and functional studies on Langerhans cells and Thy-1+ dendritic epidermal cells in the perinatal period.

Science.gov (United States)

Elbe, A; Tschachler, E; Steiner, G; Binder, A; Wolff, K; Stingl, G

1989-10-15

The adult murine epidermis harbors two separate CD45+ bone marrow (BM)-derived dendritic cell systems, i.e., Ia+, ADPase+, Thy-1-, CD3- Langerhans cells (LC) and Ia-, ADPase-, Thy-1+, CD3+ dendritic epidermal T cells (DETC). To clarify whether the maturation of these cells from their ill-defined precursors is already accomplished before their entry into the epidermis or, alternatively, whether a specific epidermal milieu is required for the expression of their antigenic determinants, we studied the ontogeny of CD45+ epidermal cells (EC). In the fetal life, there exists a considerable number of CD45+, Ia-, ADPase+ dendritic epidermal cells. When cultured, these cells become Ia+ and, in parallel, acquire the potential of stimulating allogeneic T cell proliferation. These results imply that CD45+, Ia-, ADPase+ fetal dendritic epidermal cells are immature LC precursors and suggest that the epidermis plays a decisive role in LC maturation. The day 17 fetal epidermis also contains a small population of CD45+, Thy-1+, ADPase-, CD3- round cells. Over the course of 2 to 3 wk, they are slowly replaced by an ever increasing number of round and, finally, dendritic CD45+, Thy-1+, CD3+ EC. Thus, CD45+, Thy-1+, ADPase-, CD3- fetal EC may either be DETC precursors or, alternatively, may represent a distinctive cell system of unknown maturation potential. According to this latter theory, these cells would be eventually outnumbered by newly immigrating CD45+, Thy-1+, CD3+ T cells--the actual DETC.

Caracterização anatômica e fitoquímica de folhas e rizomas de Hedychium coronarium J. König (Zingiberaceae Anatomical and phytochemical characterization of leaves and rhizomes from Hedychium coronarium J. König (Zingiberaceae

Directory of Open Access Journals (Sweden)

M.B.G Martins

2010-06-01

Full Text Available Devido a grande potencialidade na utilização de Hedychium coronarium, na medicina popular e também como biorremediadora no tratamento de efluentes, objetivou-se uma diagnose dos órgãos, folha e rizoma, para elucidar resultados estruturais e fitoquímicos. A folha é anfiestomática, com predominância de estômatos na face abaxial. Em ambas as superfícies foliares há projeções de cera epicuticular sobre as paredes anticlinais das células epidérmicas. O mesofilo dorsiventral apresenta hipoderme multisseriada (3 camadas em ambos os lados. O parênquima clorofiliano é diferenciado em paliçádico (1-2 camadas e lacunoso (4-5 camadas com muitos espaços intercelulares e ocorrência de idioblastos cristalíferos. Na nervura central, o aerênquima ocorre em único arco na região abaxial. Os feixes vasculares distribuem-se aleatoriamente e são de diferentes tamanhos, pequenos, médios e grandes, envolvidos por fibras. Os feixes menores localizam-se no lado abaxial da nervura. A triagem fitoquímica das folhas mostrou a presença de saponinas e ausência de taninos, antraquinonas, alcalóides e flavonóides. Por meio de Cromatografia em Camada Delgada foram identificadas as presenças de cariofileno e mirceno no óleo essencial bruto obtido a partir das folhas de H. coronarium.Due to the great potentiality regarding the use of Hedychium coronarium in folk medicine and also as a bioremediator in effluent treatment, this study aimed to diagnose leaf and rhizome in order to elucidate structural and phytochemical results. Hedychium coronarium leaf is amphistomatal, with predominance of stomata on the abaxial surface. On both leaf surfaces, there are epicuticular wax projections over the anticlinal walls from epidermal cells. The dorsiventral mesophyll presents multiseriate (3 layers hypoderm on both sides. The chlorophyllian parenchyma is differentiated into palisade (1-2 layers and spongy (4-5 layers with many intercellular spaces and some

Efficiency measurements for 3D silicon strip detectors

Energy Technology Data Exchange (ETDEWEB)

Parzefall, Ulrich, E-mail: ulrich.parzefall@physik.uni-freiburg.d [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Dalla Betta, Gian-Franco [INFN Trento and Universita di Trento, via Sommarive 14, 38050 Povo di Trento (Italy); Boscardin, Maurizio [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy); Eckert, Simon [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Eklund, Lars; Fleta, Celeste [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Jakobs, Karl; Koehler, Michael; Kuehn, Susanne; Pahn, Gregor [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Parkes, Chris; Pennicard, David [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Ronchin, Sabina [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy); Zoboli, Andrea [INFN Trento and Universita di Trento, via Sommarive 14, 38050 Povo di Trento (Italy); Zorzi, Nicola [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy)

2010-11-01

Silicon strip detectors are widely used as part of the inner tracking layers in particle physics experiments. For applications at the luminosity upgrade of the Large Hadron Collider (LHC), the sLHC, silicon detectors with extreme radiation hardness are required. The 3D detector design, where electrodes are processed from underneath the strips into the silicon bulk material, provides a way to enhance the radiation tolerance of standard planar silicon strip detectors. Detectors with several innovative 3D designs that constitute a simpler and more cost-effective processing than the 3D design initially proposed were connected to read-out electronics from LHC experiments and subsequently tested. Results on the amount of charge collected, the noise and the uniformity of charge collection are given.

First results from a silicon-strip detector with VLSI readout

International Nuclear Information System (INIS)

Anzivino, G.; Horisberger, R.; Hubbeling, L.; Hyams, B.; Parker, S.; Breakstone, A.; Litke, A.M.; Walker, J.T.; Bingefors, N.

1986-01-01

A 256-strip silicon detector with 25 μm strip pitch, connected to two 128-channel NMOS VLSI chips (Microplex), has been tested using straight-through tracks from a ruthenium beta source. The readout channels have a pitch of 47.5 μm. A single multiplexed output provides voltages proportional to the integrated charge from each strip. The most probable signal height from the beta traversals is approximately 14 times the rms noise in any single channel. (orig.)

KRITIK SOSIAL DALAM KOMIK STRIP PAK BEI

Directory of Open Access Journals (Sweden)

Yudhi Novriansyah

2016-08-01

Full Text Available This research aimed to do interpret the marking which flange social criticism and know laboring ideology in story of Comic Strip Pak Bei. Research based on theory of structural semiotic according to Ferdinand De Saussure. Using analysis of Syntagmatic as first level of meaning to the text network and also picture, and analysis of Paradigmatic as second level of meaning or implicit meaning (connota-tion, myth, ideology Analysis done to six Comic choice edition of Strip Pak Bei period of November 2004 - Februari 2005 which tend to flange social criticism. At band of syntagmatic, result of research indicate that story theme lifted from social problems that happened in major society. The fact clear progressively when connected by Intertextual with information and texts which have preexisted. At band of Paradigmatic, social criticism tend to emerge dimly, is not transparent. Because of Comic Strip Pak Bei expand in the middle of Java cultural domination that developing myth of criticize as action menacing compatibility and orderliness of society. Story of Comic Strip Pak Bei also confirm dominant ideology in Java society culture, namely ideology of Patriarkhi and Feudalism which still go into effect until now. This prove ideology idea according to Louis Althusser which not again opposition between class, but have been owned and practiced by all social class.

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

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Sabita N. Saldanha

2015-12-01

Full Text Available As an actively renewable tissue, changes in skin architecture are subjected to the regulation of stem cells that maintain the population of cells responsible for the formation of epidermal layers. Stems cells retain their self-renewal property and express biomarkers that are unique to this population. However, differential regulation of the biomarkers can initiate the pathway of terminal cell differentiation. Although, pockets of non-clarity in stem cell maintenance and differentiation in skin still exist, the influence of epigenetics in epidermal stem cell functions and differentiation in skin homeostasis and wound healing is clearly evident. The focus of this review is to discuss the epigenetic regulation of confirmed and probable epidermal stem cell biomarkers in epidermal stratification of normal skin and in diseased states. The role of epigenetics in wound healing, especially in diseased states of diabetes and cancer, will also be conveyed.

Characterization and Calibration of Large Area Resistive Strip Micromegas Detectors

CERN Document Server

Losel, Philipp Jonathan; The ATLAS collaboration

2015-01-01

Resisitve strip Micromegas detectors behave discharge tolerant. They have been tested extensively as smaller detectors of about 10 x 10 cm$^2$ in size and they work reliably at high rates of 100\\,kHz/cm$^2$ and above. Tracking resolutions well below 100\\,$\\mu$m have been observed for 100 GeV muons and pions. Micromegas detectors are meanwhile proposed as large area muon precision trackers of 2-3\\,m$^2$ in size. To investigate possible differences between small and large detectors, a 1\\,m$^2$ detector with 2048 resistive strips at a pitch of 450 $\\mu$m was studied in the LMU Cosmic Ray Facility (CRF) using two 4 $\\times$ 2.2 m$^2$ large Monitored Drift Tube (MDT) chambers for cosmic muon reference tracking. Segmentation of the resistive strip anode plane in 57.6\\,mm x 95\\,mm large areas has been realized by the readout of 128 strips with one APV25 chip each and by 11 95\\,mm broad trigger scintillators placed along the readout strips.\\\\ This allows for mapping of homogenity in pulse height and efficiency, deter...

Tc-99m-MDP scintigraphy in the evaluation of epidermal nevus syndrome

International Nuclear Information System (INIS)

Barbosa, M.N.S.; Cunha, M.O.; Severiche, A.F.A.; Ramos, C.D.; Etchebehere, E.C.S.C.; Belangero, W.; Camargo, E.E.

1997-01-01

Full text: Epidermal nevus syndrome has been described as a congenital neurocutaneous disorder in which epidermal nevi are associated with malformations of other organs, commonly the skeleton and central nervous system. Ocular, cardiac, and genitourinary system abnormalities, as well as other skin lesions, may also be seen. A 19 year old patient with epidermal nevus syndrome, presenting congenital facial epidermal nevi and bone deformity of the lower limbs (shortening of the left leg, left thigh varum, bilateral genu valgum, and multiple pathological fractures), as referred to the nuclear medicine laboratory to evaluate involvement of other sites of the skeleton. Whole body bone scintigraphy performed with MDP-Tc-99m showed multiple small focal areas of increased uptake in the skeleton, mainly in the upper and lower limbs, posterior ribs, right acetabulum, right sacroiliac joint, and right greater trochanter, interpreted as pathological fractures at different stages of remodeling. The range of skeletal findings in this condition is quite diverse. Many of these findings can be attributed to local tissue overgrowth with deformities and advanced bone age, associate with pathological fractures

Humor in elementary science: Development and evaluation of comic strips about sound

Directory of Open Access Journals (Sweden)

Ertuğrul Özdemir

2017-06-01

Full Text Available Comic strips on newspapers, magazines and Internet are one of the most accessible materials that may be used in science classroom as instructional tool. However, it is sometimes difficult to find and adapt appropriate comic strips useful for instructional purposes, because most of them are irrelevant. The purpose of this study is to develop and evaluate instructional comic strips aiming to contribute learning about sound related concepts. In this study, a series of instructional comic strips were created and implemented to a group of seventh grade students. Students’ responses to a number of open-ended questions were evaluated through qualitative content analysis. According to results, most of the students believed that comic strips help learning through simplifying science concepts and making retention of them easier. In addition, comic strips seemed to contribute students’ enjoyment toward science and perception of success in science.

Performance of a new test strip for freestyle blood glucose monitoring systems.

Science.gov (United States)

Lock, John Paul; Brazg, Ronald; Bernstein, Robert M; Taylor, Elizabeth; Patel, Mona; Ward, Jeanne; Alva, Shridhara; Chen, Ting; Welsh, Zoë; Amor, Walter; Bhogal, Claire; Ng, Ronald

2011-01-01

a new strip, designed to enhance the ease of use and minimize interference of non-glucose sugars, has been developed to replace the current FreeStyle (Abbott Diabetes Care, Alameda, CA) blood glucose test strip. We evaluated the performance of this new strip. laboratory evaluation included precision, linearity, dynamic range, effects of operating temperature, humidity, altitude, hematocrit, interferents, and blood reapplication. System accuracy, lay user performance, and ease of use for finger capillary blood testing and accuracy for venous blood testing were evaluated at clinics. Lay users also compared the speed and ease of use between the new strip and the current FreeStyle strip. for glucose concentrations blood glucose results obtained by lay users fell within ± 5, 10, and 15 mg/dL, respectively, of the reference. For glucose concentrations ≥75 mg/dL, 68%, 95%, 99%, and 99% of the lay user results fell within  ±  5%, 10%, 15%, and 20%, respectively, of the reference. Comparable accuracy was obtained in the venous blood study. Lay users found the new test strip easy to use and faster and easier to use than the current FreeStyle strip. The new strip maintained accuracy under various challenging conditions, including high concentrations of various interferents, sample reapplication up to 60 s, and extremes in hematocrit, altitude, and operating temperature and humidity. our results demonstrated excellent accuracy of the new FreeStyle test strip and validated the improvements in minimizing interference and enhancing ease of use.

A design aid for sizing filter strips using buffer area ratio

Science.gov (United States)

M.G. Dosskey; M.J. Helmers; D.E. Eisenhauer

2011-01-01

Nonuniform field runoff can reduce the effectiveness of filter strips that are a uniform size along a field margin. Effectiveness can be improved by placing more filter strip where the runoff load is greater and less where the load is smaller. A modeling analysis was conducted of the relationship between pollutant trapping efficiency and the ratio of filter strip area...

Ruptured Epidermal Inclusion Cysts in the Subareolar Area: Sonographic Findings in Two Cases

Energy Technology Data Exchange (ETDEWEB)

Whang, In Yong; Lee, Jae Hee; Kim, Jeong Soo; Kim, Ki Tae; Shin, Ok Ran [Uijongbu St. Mary' s Hospital, Catholic University College of Medicine, Seoul (Korea, Republic of)

2007-08-15

We report here on two cases of ruptured epidermal inclusion cysts in the subareolar area, which is a very unusual location for these cysts and these lesions can be mistaken for breast malignancies. Although the epidermal inclusion cyst is an uncommon finding in the breast, we can easily diagnosis this as a cyst. But when it is presented in an unusual subareolar location and with a ruptured state, it can be mistaken for breast malignancy. We present here two surgically confirmed cases of ruptured epidermal inclusion cyst in a subareolar location, and this has not been previously described in the English medical literature. In our cases, we first considered the possibility of breast malignancy because the masses presented as an irregular mass on the initial sonography, and the patients were over the age 40 and we didn't take the possibility of abscess from ruptured epidermal inclusion cyst into consideration due to its rare occurrence and the unusual lesion location. FNAB and follow up imaging study after medical treatment, or the recurrent feature were the ways to later narrow the differential diagnosis. In conclusion, when a subareolar lesion has findings on sonography that are suspicious of malignancy, the differential diagnosis should include a ruptured epidermal inclusion cyst, with or without evidence of inflammation.

Ruptured Epidermal Inclusion Cysts in the Subareolar Area: Sonographic Findings in Two Cases

International Nuclear Information System (INIS)

Whang, In Yong; Lee, Jae Hee; Kim, Jeong Soo; Kim, Ki Tae; Shin, Ok Ran

2007-01-01

We report here on two cases of ruptured epidermal inclusion cysts in the subareolar area, which is a very unusual location for these cysts and these lesions can be mistaken for breast malignancies. Although the epidermal inclusion cyst is an uncommon finding in the breast, we can easily diagnosis this as a cyst. But when it is presented in an unusual subareolar location and with a ruptured state, it can be mistaken for breast malignancy. We present here two surgically confirmed cases of ruptured epidermal inclusion cyst in a subareolar location, and this has not been previously described in the English medical literature. In our cases, we first considered the possibility of breast malignancy because the masses presented as an irregular mass on the initial sonography, and the patients were over the age 40 and we didn't take the possibility of abscess from ruptured epidermal inclusion cyst into consideration due to its rare occurrence and the unusual lesion location. FNAB and follow up imaging study after medical treatment, or the recurrent feature were the ways to later narrow the differential diagnosis. In conclusion, when a subareolar lesion has findings on sonography that are suspicious of malignancy, the differential diagnosis should include a ruptured epidermal inclusion cyst, with or without evidence of inflammation

Science comic-strips on display at Microcosm

CERN Document Server

Alix Marcastel

2011-01-01

To mark the publication of his new comic-strip "Les Vies de Marie Curie", the Genevan artist Fiami will be placing some of his previous creations on the theme "women and science" on display at CERN. The new comic-strip pays tribute to the illustrious Nobel prize-winner by taking a light-hearted look at the history of chemistry and how the role of women scientists in society has evolved through the ages.   It's no easy task,  presenting the history of science to the general public in a light-hearted way. As part of the various events organised in the Fête de la Science and the Europeans Researchers Night, CERN will be hosting an exhibition entirely devoted to the comic-strips created by Fiami. The artist describes his comics as "a relaxed way of looking at serious and apparently highly complex subjects."  Fiami's very latest creation, Les Vies de Marie Curie, published in June 2011, celebrates th...

Epidermal growth factor in mammary glands and milk from rats

DEFF Research Database (Denmark)

Thulesen, J; Raaberg, Lasse; Nexø, Ebba

1993-01-01

Epidermal growth factor (EGF) is one of the major growth-promoting agents in milk. Using immunohistochemistry we localized EGF in the mammary glands of lactating rats to the luminal border of the secretory cells. Following proteolytic pretreatment of the histological sections, the EGF-immunoreact......Epidermal growth factor (EGF) is one of the major growth-promoting agents in milk. Using immunohistochemistry we localized EGF in the mammary glands of lactating rats to the luminal border of the secretory cells. Following proteolytic pretreatment of the histological sections, the EGF...

The Argonne silicon strip-detector array

Energy Technology Data Exchange (ETDEWEB)

Wuosmaa, A H; Back, B B; Betts, R R; Freer, M; Gehring, J; Glagola, B G; Happ, Th; Henderson, D J; Wilt, P [Argonne National Lab., IL (United States); Bearden, I G [Purdue Univ., Lafayette, IN (United States). Dept. of Physics

1992-08-01

Many nuclear physics experiments require the ability to analyze events in which large numbers of charged particles are detected and identified simultaneously, with good resolution and high efficiency, either alone, or in coincidence with gamma rays. The authors have constructed a compact large-area detector array to measure these processes efficiently and with excellent energy resolution. The array consists of four double-sided silicon strip detectors, each 5x5 cm{sup 2} in area, with front and back sides divided into 16 strips. To exploit the capability of the device fully, a system to read each strip-detector segment has been designed and constructed, based around a custom-built multi-channel preamplifier. The remainder of the system consists of high-density CAMAC modules, including multi-channel discriminators, charge-sensing analog-to-digital converters, and time-to-digital converters. The array`s performance has been evaluated using alpha-particle sources, and in a number of experiments conducted at Argonne and elsewhere. Energy resolutions of {Delta}E {approx} 20-30 keV have been observed for 5 to 8 MeV alpha particles, as well as time resolutions {Delta}T {<=} 500 ps. 4 figs.

Determination of residual stresses in roll compacted titanium strips

CSIR Research Space (South Africa)

Mothosi, KL

2017-01-01

Full Text Available residual stresses using x-ray diffraction (XRD) surface probing technique. Preliminary results were obtained for the surface residual stress at the center of the titanium strips for the 100 and 325 mesh strips rolled at 0.1 roll gap for 20 and 50 mm set...

Optimising carbon electrode materials for adsorptive stripping voltammetry

OpenAIRE

Chaisiwamongkhol, K; Batchelor-McAuley, C; Sokolov, S; Holter, J; Young, N; Compton, R

2017-01-01

Different types of carbon electrode materials for adsorptive stripping voltammetry are studied through the use of cyclic voltammetry. Capsaicin is utilised as a model compound for adsorptive stripping voltammetry using unmodified and modified basal plane pyrolytic graphite (BPPG) electrodes modified with multi-walled carbon nanotubes, carbon black or graphene nanoplatelets, screen printed carbon electrodes (SPE), carbon nanotube modified screen printed electrodes, and carbon paste electrodes....

Method of stripping solid particles

International Nuclear Information System (INIS)

1980-01-01

A method of stripping loaded solid particles is specified in which uniform batches of the loaded particles are passed successively upwardly through an elution column in the form of discrete plugs, the particles of which do not intermingle substantially with the particles of the vertically adjacent plug(s), and are contacted therein with eluant liquid flowed downwardly, strong eluate being withdrawn from the lower region of the column, the loaded particles being supplied as a slurry in a carrier liquid, and successive batches of loaded particles being isolated as measured batches and being separated from their carrier liquid before being contacted with strong eluate and slurried with the strong eluate into the lower region of the column. An example describes the stripping of ion exchange resin particles loaded with complex uranium ions. (author)

Process for recovering uranium using an alkyl pyrophosphoric acid and alkaline stripping solution

International Nuclear Information System (INIS)

Worthington, R.E.; Magdics, A.

1987-01-01

A process is described for stripping uranium for a pregnant organic extractant comprising an alkyl pyrophosphoric acid dissolved in a substantially water-immiscible organic diluent. The organic extractant contains tetravalent uranium and an alcohol or phenol modifier in a quantity sufficient to retain substantially all the unhydrolyzed alkyl pyrophosphoric acid in solution in the diluent during stripping. The process comprises adding an oxidizing agent to the organic extractant and thereby oxidizing the tetravalent uranium to the +6 state in the organic extractant, and contacting the organic extractant containing the uranium in the +6 state with a stripping solution comprising an aqueous solution of an alkali metal or ammonium carbonate or hydroxide thereby stripping uranium from the organic extractant into the stripping solution. The resulting barren organic extractant containing substantially all of the unhydrolyzed alkyl pyrophosphoric acid dissolved in the diluent is separated from the stripping solution containing the stripped uranium, the barren extractant being suitable for recycle

Single electron attachment and stripping cross sections for relativistic heavy ions

International Nuclear Information System (INIS)

Crawford, H.J.

1979-06-01

The results of a Bevalac experiment to measure the single electron attachment and stripping cross sections for relativistic (0.5 1 , and fully stripped, N 0 , ion beams emerging from the targets. Separate counters measured the number of ions in each charge state. The ratios N 1 /N 0 for different target thicknesses were fit to a simple growth curve to yield electron attachment and stripping cross sections. The data are compared to relativistic extrapolations of available theories. Clear evidence for two separate attachment processes, radiative and non-radiative, is found. Data are compared to a recently improved formulation for the stripping cross sections

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Directory of Open Access Journals (Sweden)

French Lars E

2010-12-01

Full Text Available Abstract Toxic epidermal necrolysis (TEN and Stevens Johnson Syndrome (SJS are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Currently, TEN and SJS are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of skin detachment. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full-thickness epidermal necrolysis due to extensive keratinocyte apoptosis. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP, disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS. Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, evaluation of the prognosis

Observational study on the pavement performance effects of shoulder rumble strip on shoulders

Directory of Open Access Journals (Sweden)

Sean Coffey

2016-07-01

Full Text Available Rumble strip implementation has shown a constant increase with its safety benefits. Rumble strips are milled into the roadway shoulder to produce noise and vibrations when driven on. With the milling process, the pavement performance is expected to be negatively impacted by the decreased depth, though not mathematically quantified. Using methods defined by the Long-Term Pavement Performance Program, the severity of the shoulder site’s distresses, with and without shoulder rumble strips, will be quantified. The quantification would permit the design to compensate for the impact. This design compensation allows the implementation of hard shoulder running, the use of shoulder as a travel lane during congestion, and retains the shoulder rumble strip safety instead of removing, as suggested by some proposed projects. While hard shoulder running would not impact specific time periods, the safety benefit of rumble strips could be needed at any time. This study aims to quantify the rumble strip impact to enable the full shoulder strength for hard shoulder running while retaining the safety benefits of rumble strips. Keywords: Rumble strips, Shoulder, Cracking, Pavement performance, Hard shoulder running

A review of toxic epidermal necrolysis management in Japan

Directory of Open Access Journals (Sweden)

Yuri Kinoshita

2017-01-01

Full Text Available Toxic epidermal necrolysis (TEN is a severe adverse drug reaction characterized by necrosis of the epidermis. Its incidence is approximately 1 per million a year and average mortality rate is high at 25–50%. TEN has a flu-like prodrome, followed by atypical, targetoid erythematous or purpuric macules on the skin. These macules coalesce to form flaccid blisters that slough off as areas of epidermal necrosis. Drugs such as allopurinol, sulfonamides, and carbamazepine are the most common causes. The human leukocyte antigen (HLA-B*15:02 in Asians being administered carbamazepine and the HLA-B*58:01 antigen in patients of all ethnicities being administered allopurinol are known to be high-risk factors. Rapid diagnosis, discontinuation of the causative drug, and supportive treatment are essential for better prognosis and improvement of sequelae. Till now, systemic corticosteroids and intravenous immunoglobulins have been used as the most common active interventions; however, no gold standard has been established. In Japan, physicians follow a unique diagnostic criteria and treatment guideline to improve the diagnosis rate and streamline treatments. This may be a contributing factor for the lower mortality rate (14.3%. The efficacy of systemic corticosteroids, immunoglobulins, and plasmapheresis may have been beneficial as well. In Japan, TEN is defined as an epidermal detachment of over 10% of the body surface area (BSA, while the globally accepted definition established by Bastuji-Garin describes it as an epidermal detachment of over 30% of the BSA. In Japanese individuals, HLA-A*02:06, HLA-A*02:07, HLA-A*31:01 and HLA-B*51:01 may be linked to higher risks of TEN.

slice of LEP beamtube with getter strip

CERN Multimedia

1989-01-01

A section of the LEP beam pipe. This is the chamber in which LEP's counter-rotating electron and positron beams travel. It is made of lead-clad aluminium. The beams circulate in the oval cross-section part of the chamber. In the rectangular cross-section part, LEP's innovative getter-strip vacuum pump is installed. After heating to purify the surface of the getter, the strip acts like molecular sticky tape, trapping any stray molecules left behind after the accelerator's traditional vacuum pumps have done their job.

Influence for high intensity irradiation on characteristics of silicon strip-detectors

International Nuclear Information System (INIS)

Anokhin, I.E.; Pugatch, V.M.; Zinets, O.S.

1995-01-01

Full text: Silicon strip detectors (SSD) are widely used for the coordinate determination of short-range as well as minimum ionizing particles with high spatial resolution. Submicron position sensitivity of strip-detectors for short-range particles has been studied by means of two dimensional analyses of charges collected by neighboring strips as well as by measurement of charge collection times [1]. Silicon strip detectors was also used for testing high energy electron beam [2]. Under large fluences the radiation defects are stored and such characteristics of strip-detectors as an accuracy of the coordinate determination and the registration efficiency are significantly changed. Radiation defects lead to a decrease of the lifetime and mobility of charge carriers and therefore to changes of conditions for the charge collection in detectors. The inhomogeneity in spatial distribution if defects and electrical field plays an important role in the charge collection. In this report the role of the diffusion and drift in the charge collection in silicon strip-detectors under irradiation up to 10 Mrad has been studied. The electric field distribution and its dependence on the radiation dose in the detector have been calculated. It is shown that for particles incident between adjacent strips the coordinate determination precision depends strongly on the detector geometry and the electric field distribution, particularly in the vicinity of strips. Measuring simultaneously the collected charges and collection times on adjacent strips one can essentially improve reliability of the coordinate determination for short-range particles. Usually SSD are fabricated on n-type wafers. It is well known that under high intensity irradiation n-Si material converts into p-Si as far as p-type silicon is more radiative hard than n-type silicon [3] it is reasonable to fabricate SSD using high resistivity p-Si. Characteristics of SSD in basis n-and P-Si have been compared and higher

Caracterização anatômica e química de folhas de Jacaranda puberula (Bignoniaceae presente na Mata Atlântica

Directory of Open Access Journals (Sweden)

Maria Bernadete Gonçalves Martins

Full Text Available A espécie Jacaranda puberula (Bignoniaceae é conhecida popularmente como "carobinha" sendo utilizada na medicina popular em comunidades tradicionais. O objetivo deste trabalho foi realizar a caracterização anatômica e química das folhas de J. puberula. Para a análise anatômica utilizou-se a microscopia de luz e microscopia eletrônica de varredura (MEV. Para a análise química utilizou-se a Cromatografia Líquida de Alta Eficiência (CLAE. O mesofilo é dorsiventral, a epiderme unisseriada com cutícula espessa, tricomas glandulares do tipo peltado e tricomas tectores em ambas as faces da epiderme, parênquima clorofiliano com duas a três camadas de células paliçádicas e quatro a cinco camadas de células formando o parênquima lacunoso, de tamanho pequeno, com muitos espaços intercelulares, hipoestomática com nervura pinada. Os estudos através de MEV evidenciaram a epiderme recoberta com cera epicuticular e glândulas peltadas com maior incidência na epiderme da face abaxial, constituídas por oitos células secretoras apicais. A análise cromatográfica do extrato etanólico evidenciou a presença de fitoquinóides e flavonóides.

Comparisons of boll weevil (Coleoptera: Curculionidae) pheromone traps with and without kill strips.

Science.gov (United States)

Suh, C P C; Armstrong, J S; Spurgeon, D W; Duke, S

2009-02-01

Boll weevil, Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae), eradication programs typically equip pheromone traps with an insecticide-impregnated kill strip. These strips are intended to kill captured insects, thereby simplifying trap servicing and reducing the loss of weevils from predation and escape. However, the effectiveness of kill strips has not been extensively evaluated. We examined the influences of kill strips on weevil captures, trap servicing, and the incidences of weevil predation and trap obstruction (e.g., by spider webs). Evaluations were conducted weekly during three different production periods (pre- to early-, late-, and postseason) of cotton, Gossypium hirsutum L., to represent different environmental conditions and weevil population levels. Within each period, mean weekly captures of weevils in traps with and without kill strips were statistically similar. On average, traps with kill strips took 9 s longer to service than traps without kill strips, but statistical differences were only detected during the late-season period. Overall, the mean weekly proportion of traps with evidence of weevil predation or trap obstruction was significantly lower for traps with kill strips (0.25) than for traps without kill strips (0.37). However, this reduction in the frequency of weevil predation or trap obstruction was too small to produce a corresponding increase in the numbers of weevils captured. In light of these findings, the use of kill strips is likely unnecessary in eradication programs, but may be a consideration in situations when the numbers of deployed traps are reduced and chronic problems with weevil predation or trap obstruction exist.

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis ...

African Journals Online (AJOL)

REVIEW. Introduction. Stevens-Johnson syndrome (SJS) and toxic epidermal ... that affect the skin and mucous membranes. ... Open Access article distributed under the terms of the .... pathogenic components are removed from plasma. The.

Numerical analysis of edge effects in side illuminated strip detectors for digital radiology

CERN Document Server

Krizaj, D

2000-01-01

The influence of edge defects on side illuminated X-ray strip detectors for digital radiology is investigated by numerical device modeling. By assuming positive fixed oxide charges on side and top surfaces simulations have shown strong curvature of the equipotential lines in the edge region. A fraction of the edge generated current surpasses the edge guard-ring junction and is collected by the readout strips. As a consequence, strips cannot be placed close to the edge of the structure and collection efficiency is reduced. An n-on-n instead of a p-on-n strip detector is proposed enabling collection of edge generated carriers by a very narrow guard-ring junction and placement of the readout strip close to the edge without increase of the strip leakage current.

Epidermal cell death in frogs with chytridiomycosis

Directory of Open Access Journals (Sweden)

Laura A. Brannelly

2017-02-01

Full Text Available Background Amphibians are declining at an alarming rate, and one of the major causes of decline is the infectious disease chytridiomycosis. Parasitic fungal sporangia occur within epidermal cells causing epidermal disruption, but these changes have not been well characterised. Apoptosis (planned cell death can be a damaging response to the host but may alternatively be a mechanism of pathogen removal for some intracellular infections. Methods In this study we experimentally infected two endangered amphibian species Pseudophryne corroboree and Litoria verreauxii alpina with the causal agent of chytridiomycosis. We quantified cell death in the epidermis through two assays: terminal transferase-mediated dUTP nick end-labelling (TUNEL and caspase 3/7. Results Cell death was positively associated with infection load and morbidity of clinically infected animals. In infected amphibians, TUNEL positive cells were concentrated in epidermal layers, correlating to the localisation of infection within the skin. Caspase activity was stable and low in early infection, where pathogen loads were light but increasing. In animals that recovered from infection, caspase activity gradually returned to normal as the infection cleared. Whereas, in amphibians that did not recover, caspase activity increased dramatically when infection loads peaked. Discussion Increased cell death may be a pathology of the fungal parasite, likely contributing to loss of skin homeostatic functions, but it is also possible that apoptosis suppression may be used initially by the pathogen to help establish infection. Further research should explore the specific mechanisms of cell death and more specifically apoptosis regulation during fungal infection.

Generalized thick strip modelling for vortex-induced vibration of long flexible cylinders

International Nuclear Information System (INIS)

Bao, Y.; Palacios, R.; Graham, M.; Sherwin, S.

2016-01-01

We propose a generalized strip modelling method that is computationally efficient for the VIV prediction of long flexible cylinders in three-dimensional incompressible flow. In order to overcome the shortcomings of conventional strip-theory-based 2D models, the fluid domain is divided into “thick” strips, which are sufficiently thick to locally resolve the small scale turbulence effects and three dimensionality of the flow around the cylinder. An attractive feature of the model is that we independently construct a three-dimensional scale resolving model for individual strips, which have local spanwise scale along the cylinder's axial direction and are only coupled through the structural model of the cylinder. Therefore, this approach is able to cover the full spectrum for fully resolved 3D modelling to 2D strip theory. The connection between these strips is achieved through the calculation of a tensioned beam equation, which is used to represent the dynamics of the flexible body. In the limit, however, a single “thick” strip would fill the full 3D domain. A parallel Fourier spectral/hp element method is employed to solve the 3D flow dynamics in the strip-domain, and then the VIV response prediction is achieved through the strip–structure interactions. Numerical tests on both laminar and turbulent flows as well as the comparison against the fully resolved DNS are presented to demonstrate the applicability of this approach.

Generalized thick strip modelling for vortex-induced vibration of long flexible cylinders

Energy Technology Data Exchange (ETDEWEB)

Bao, Y., E-mail: ybao@sjtu.edu.cn [Department of Civil Engineering, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiaotong University, No. 800 Dongchuan Road, Shanghai (China); Department of Aeronautics, Imperial College London, South Kensington Campus, London (United Kingdom); Palacios, R., E-mail: r.palacios@imperial.ac.uk [Department of Aeronautics, Imperial College London, South Kensington Campus, London (United Kingdom); Graham, M., E-mail: m.graham@imperial.ac.uk [Department of Aeronautics, Imperial College London, South Kensington Campus, London (United Kingdom); Sherwin, S., E-mail: s.sherwin@imperial.ac.uk [Department of Aeronautics, Imperial College London, South Kensington Campus, London (United Kingdom)

2016-09-15

We propose a generalized strip modelling method that is computationally efficient for the VIV prediction of long flexible cylinders in three-dimensional incompressible flow. In order to overcome the shortcomings of conventional strip-theory-based 2D models, the fluid domain is divided into “thick” strips, which are sufficiently thick to locally resolve the small scale turbulence effects and three dimensionality of the flow around the cylinder. An attractive feature of the model is that we independently construct a three-dimensional scale resolving model for individual strips, which have local spanwise scale along the cylinder's axial direction and are only coupled through the structural model of the cylinder. Therefore, this approach is able to cover the full spectrum for fully resolved 3D modelling to 2D strip theory. The connection between these strips is achieved through the calculation of a tensioned beam equation, which is used to represent the dynamics of the flexible body. In the limit, however, a single “thick” strip would fill the full 3D domain. A parallel Fourier spectral/hp element method is employed to solve the 3D flow dynamics in the strip-domain, and then the VIV response prediction is achieved through the strip–structure interactions. Numerical tests on both laminar and turbulent flows as well as the comparison against the fully resolved DNS are presented to demonstrate the applicability of this approach.

Design, Analysis, and On-Sun Evaluation of Reflective Strips Under Controlled Buckling

Science.gov (United States)

Jaworske, Donald A.; Sechkar, Edward A.; Colozza, Anthony J.

2014-01-01

Solar concentrators are envisioned for use in a variety of space-based applications, including applications involving in situ resource utilization. Identifying solar concentrators that minimize mass and cost are of great interest, especially since launch cost is driven in part by the mass of the payload. Concentrators must also be able to survive the wide temperature excursions on the lunar surface. Identifying smart structures which compensate for changes in concentrator geometry brought about by temperature extremes are of interest. Some applications may benefit from the ability to change the concentrators focal pattern at will. This paper addresses a method of designing a single reflective strip to produce a desired focal pattern through the use of controlled buckling. Small variations in the cross section over the length of the reflective strip influence the distribution of light in the focal region. A finite element method of analysis is utilized here which calculates the curve produced for a given strip cross section and axial load. Varying axial force and strip cross section over the length of the reflective strip provide a means of optimizing ray convergence in the focal region. Careful selection of a tapered cross section yields a reflective strip that approximates a parabola. An array of reflective strips under controlled buckling produces a light weight concentrator and adjustments in the compression of individual strips provide a means of compensating for temperature excursions or changing the focal pattern at will.

360-degrees profilometry using strip-light projection coupled to Fourier phase-demodulation.

Science.gov (United States)

Servin, Manuel; Padilla, Moises; Garnica, Guillermo

2016-01-11

360 degrees (360°) digitalization of three dimensional (3D) solids using a projected light-strip is a well-established technique in academic and commercial profilometers. These profilometers project a light-strip over the digitizing solid while the solid is rotated a full revolution or 360-degrees. Then, a computer program typically extracts the centroid of this light-strip, and by triangulation one obtains the shape of the solid. Here instead of using intensity-based light-strip centroid estimation, we propose to use Fourier phase-demodulation for 360° solid digitalization. The advantage of Fourier demodulation over strip-centroid estimation is that the accuracy of phase-demodulation linearly-increases with the fringe density, while in strip-light the centroid-estimation errors are independent. Here we proposed first to construct a carrier-frequency fringe-pattern by closely adding the individual light-strip images recorded while the solid is being rotated. Next, this high-density fringe-pattern is phase-demodulated using the standard Fourier technique. To test the feasibility of this Fourier demodulation approach, we have digitized two solids with increasing topographic complexity: a Rubik's cube and a plastic model of a human-skull. According to our results, phase demodulation based on the Fourier technique is less noisy than triangulation based on centroid light-strip estimation. Moreover, Fourier demodulation also provides the amplitude of the analytic signal which is a valuable information for the visualization of surface details.

Epidermal growth factor enemas for induction of remission in left-sided ulcerative colitis

Directory of Open Access Journals (Sweden)

Hugo Nodarse-Cuní

2013-03-01

Full Text Available Introduction: ulcerative colitis is a little known chronic inflammatory disease in colonic mucosa. The positive effect of epidermal growth factor was shown in a previous report, with enema use for treatment of mild to moderate left-sided manifestation of the disease. This evidence provided the basis for evaluating the efficacy and safety profile of a viscous solution of this product. Methods: thirty-one patients were randomized to three groups for daily medications during 14 days. Twelve received one 10 mg enema of epidermal growth factor dissolved in 100 mL of viscous solution whereas nine were treated with placebo enema; both groups also received 1.2 g of oral mesalamine per day. The other group included ten patients with 3 g / 100 mL of mesalamine enema. Primary end point was clinical responses after two weeks of treatment, defined as a decreased of, at least three points from baseline, the Disease Activity Index and endoscopic or histological evidences of improvement. Results: remission of disease was observed in all patients in the epidermal growth factor group, and six in both, mesalamine enema and placebo group. All the comparisons between groups showed statistically significant superiority for epidermal growth factor, the only product with significant reduction in disease activity index as well as the presence and intensity of digestive symptoms in patients after treatment. None adverse event was reported. Conclusions: the results agree with previous molecular and clinical evidences, indicating that the epidermal growth factor is effective to reduce disease activity and to induce remission. A new study involving more patients should be conducted to confirm the efficacy of the epidermal growth factor enemas.

The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification.

Science.gov (United States)

Chang, Wing Y; Bryce, Dawn M; D'Souza, Sudhir J A; Dagnino, Lina

2004-12-03

The epidermis is a stratified epithelium constantly replenished through the ability of keratinocytes in its basal layer to proliferate and self-renew. The epidermis arises from a single-cell layer ectoderm during embryogenesis. Large proliferative capacity is central to ectodermal cell and basal keratinocyte function. DP-1, a heterodimeric partner of E2F transcription factors, is highly expressed in the ectoderm and all epidermal layers during embryogenesis. To investigate the role of DP-1 in epidermal morphogenesis, we inhibited DP-1 activity through exogenous expression of a dominant-negative mutant (dnDP-1). Expression of the dnDP-1 mutant interferes with binding of E2F/DP-1 heterodimers to DNA and inhibits DNA replication, as well as cyclin A mRNA and protein expression. Chromatin immunoprecipitation analysis demonstrated that the cyclin A promoter is predominantly bound in proliferating keratinocytes by complexes containing E2F-3 and E2F-4. Thus, the mechanisms of decreased expression of cyclin A in the presence of dnDP-1 seem to involve inactivation of DP-1 complexes containing E2F-3 and E2F-4. To assess the consequences on epidermal morphogenesis of inhibiting DP-1 activity, we expressed dnDP-1 in rat epithelial keratinocytes in organotypic culture and observed that DP-1 inhibition negatively affected stratification of these cells. Likewise, expression of dnDP-1 in embryonic ectoderm explants produced extensive disorganization of subsequently formed epidermal basal and suprabasal layers, interfering with normal epidermal formation. We conclude that DP-1 activity is required for normal epidermal morphogenesis and ectoderm-to-epidermis transition.

Characterization and Calibration of Large Area Resistive Strip Micromegas Detectors

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00389527; The ATLAS collaboration

2016-01-01

Resistive strip Micromegas detectors are discharge tolerant. They have been tested extensively as small detectors of about 10 x 10 cm$^2$ in size and they work reliably at high rates of 100 kHz/cm$^2$ and above. Tracking resolution well below 100 $\\mu$m has been observed for 100 GeV muons and pions. Micromegas detectors are meanwhile proposed as large area muon precision trackers of 2-3 m$^2$ in size. To investigate possible differences between small and large detectors, a 1 m$^2$ detector with 2048 resistive strips at a pitch of 450 $\\mu$m was studied in the LMU Cosmic Ray Measurement Facility (CRMF) using two 4 $\\times$ 2.2 m$^2$ large Monitored Drift Tube (MDT) chambers for cosmic muon reference tracking. A segmentation of the resistive strip anode plane in 57.6 mm x 93 mm large areas has been realized by the readout of 128 strips with one APV25 chip each and by eleven 93 mm broad trigger scintillators placed along the readout strips. This allows for mapping of homogeneity in pulse height and efficiency, d...

FOLIAR EPIDERMAL AND PHYTOCHEMICAL STUDIES OF THE ...

African Journals Online (AJOL)

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alkaloid, saponin, inulin, cellulose, tannin and lignin; Eragrostis tremula tested negative for lignin and positive for cellulose, saponin and alkaloids while Axonopus compressus tested negative for lignin, but positive for alkaloid, saponin, inulin, cellulose and tannin respectively. Leaf epidermal studies help to determine ...

Stevens Johnsons syndrom og toksisk epidermal nekrolyse

DEFF Research Database (Denmark)

Kaur-Knudsen, Diljit; Zachariae, Claus; Thomsen, Simon Francis

2013-01-01

Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most...

Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function

Directory of Open Access Journals (Sweden)

Magdalena Boer

2016-02-01

Full Text Available The complex structure of human skin and its physicochemical properties turn it into an efficient outermost defence line against exogenous factors, and help maintain homeostasis of the human body. This role is played by the epidermal barrier with its major part – stratum corneum. The condition of the epidermal barrier depends on individual and environmental factors. The most important biophysical parameters characterizing the status of this barrier are the skin pH, epidermal hydration, transepidermal water loss and sebum excretion. The knowledge of biophysical skin processes may be useful for the implementation of prophylactic actions whose aim is to restore the barrier function.

Silicon Strip Detectors for ATLAS at the HL-LHC Upgrade

CERN Document Server

Hara, K; The ATLAS collaboration

2012-01-01

The present ATLAS silicon strip (SCT) and transition radiation (TRT) trackers will be replaced with new silicon strip detectors, as part of the Inner Tracker System (ITK), for the Phase-2 upgrade of the Large Hadron Collider, HL-LHC. We have carried out intensive R&D programs to establish radiation harder strip detectors that can survive in a radiation level up to 3000 fb-1 of integrated luminosity based on n+-on-p microstrip detector. We describe main specifications for this year’s sensor fabrication, followed by a description of possible module integration schema

Test strip and method for its use

International Nuclear Information System (INIS)

1981-01-01

A test strip device is described which is useful in performing binding assays involving antigens, antibodies, hormones, vitamins, metabolites or pharmacological agents. The device is capable of application to analytical methods in which a set of sequential test reactions is involved and in which a minute sample size may be used. This test strip is particularly useful in radioimmunoassays. The use of the device is illustrated in radioimmunoassays for 1) thyroxine in serum, 2) the triiodothyronine binding capacity of serum and 3) folic acid and its analogues in serum. (U.K.)

Wide Strip Casting Technology of Magnesium Alloys

Science.gov (United States)

Park, W.-J.; Kim, J. J.; Kim, I. J.; Choo, D.

Extensive investigations relating to the production of high performance and low cost magnesium sheet by strip casting have been performed for the application to automotive parts and electronic devices. Research on magnesium sheet production technology started in 2004 by Research Institute of Industrial Science and Technology (RIST) with support of Pohang Iron and Steel Company (POSCO). POSCO has completed the world's first plant to manufacture magnesium coil. Another big project in order to develop wide strip casting technology for the automotive applications of magnesium sheets was started in succession.

Asset Stripping in a Mature Market Economy

DEFF Research Database (Denmark)

Klarskov Jeppesen, Kim; Møller, Ulrik Gorm

2011-01-01

Purpose – The purpose of this paper is to document a Danish fraud scheme, in which a large number of limited companies were stripped of their assets leaving them with nothing but tax debt, eventually causing the Danish Tax and Customs Administration to lose large sums. Furthermore, the purpose...... indicates that asset stripping may take place in mature market economies to the extent that perpetrators are able to circumvent the corporate governance system by giving lawyers, public accountants and banks incentives to act less critically towards dubious business transactions. Research limitations...

Apparatus for irradiating a continuous line metallic strip with electron beams

International Nuclear Information System (INIS)

Matsuda, Shozo; Tanaka, Tadashi; Okamoto, Tadaaki; Ueno, Nagaharu.

1970-01-01

The secondary X-rays from an irradiated object are completely shielded by providing direction-change rollers between applicator rollers and irradiation devices. The substrate strip turns its direction of travel by 90 0 through idle rollers and before it enters a front side applicator roller. After the application of coatings, the strip travels over a roller to turn upwardly, so that the applicator is isolated from the following irradiation enclosure. Next, the irradiated strip changes its direction by 90 0 through a roller to enter a bake side coating applicator. After a direction change through a roller, the strip enters the irradiation enclosure. In this way, the applicators can prevent leakage of secondary X-rays. (Iwakiri, K.)

Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography.

Science.gov (United States)

Boone, Marc; Draye, Jean Pierre; Verween, Gunther; Pirnay, Jean-Paul; Verbeken, Gilbert; De Vos, Daniel; Rose, Thomas; Jennes, Serge; Jemec, Gregor B E; Del Marmol, Véronique

2014-10-01

While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. The aim of this paper is to evaluate the potential of high-definition optical coherence tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and decellularization. Human skin samples were incubated with four different agents: Dispase II, NaCl 1 M, sodium dodecyl sulphate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-definition optical coherence tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by reflectance confocal microscopy (RCM). (Immuno) histopathology was used as control. HD-OCT imaging allowed real-time 3-D visualization of the impact of selected agents on epidermal splitting, dermo-epidermal junction, dermal architecture, vascular spaces and cellularity. RCM has a better resolution (1 μm) than HD-OCT (3 μm), permitting differentiation of different collagen fibres, but HD-OCT imaging has deeper penetration (570 μm) than RCM imaging (200 μm). Dispase II and NaCl treatments were found to be equally efficient in the removal of the epidermis from human split-thickness skin allografts. However, a different epidermal splitting level at the dermo-epidermal junction could be observed and confirmed by immunolabelling of collagen type IV and type VII. Epidermal splitting occurred at the level of the lamina densa with dispase II and above the lamina densa (in the lamina lucida) with NaCl. The 3-D architecture of dermal papillae and dermis was more affected by Dispase II on HD-OCT which corresponded with histopathologic (orcein staining) fragmentation of elastic fibres. With SDS treatment, the epidermal removal was incomplete as remnants of the epidermal basal cell layer remained attached to the basement membrane on the dermis. With Triton X-100 treatment

Protective Effect of HemoHIM on Epidermal Melanocytes in Ultraviolet-B irradiated Mice

Energy Technology Data Exchange (ETDEWEB)

Lee, Hae June [Korea Institute of Radiological and Medical Science, Seoul (Korea, Republic of); Kim, Jong Choon; Moon, Chang Jong; Kim, Sung Ho [Chonnam National University, Gwangju (Korea, Republic of); Jung, U Hee; Park, Hae Ran; Jo, Sung Kee [Jeongeup Campus of Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Jang, Jong Sik; Kim, Tae Hwan [Kyungpook National University, Daegu (Korea, Republic of)

2011-06-15

We induced the activation of melanocytes in the epidermis of C57BL/6 mice by ultraviolet-B (UV-B) irradiation, and observed the effect of an herbal preparation (HemoHIM, HH) on the formation, and decrease of UV-B-induced epidermal melanocytes. C57BL/6 mice were irradiated by UV-B 80 mJ:cm{sup -2} (0.5 mW:sec{sup -1}) daily for 7 days, and HH was intraperitoneally, orally or topically applied pre- or post-irradiation. For the estimation of change of epidermal melanocytes, light microscopic observation with dihydroxyphenylalanine (DOPA) stain was performed. Split epidermal sheets prepared from the ear of untreated mice exhibited 13∼15 melanocytes:mm{sup -2}, and one week after UV irradiation, the applied areas showed an increased number of strongly DOPA-positive melanocytes with stout dendrites. But intraperitoneal, oral or topical treatment with HH before each irradiation interrupted UV-B-induced pigmentation and resulted in a marked reduction in the number of epidermal melanocytes as compared to the number found in UV-B-irradiated, untreated control skin. The number and size of DOPA-positive epidermal melanocytes were also significantly decreased in intraperitoneally injected or topically applicated group after irradiation with HH at 3rd and 6th weeks after irradiation. The present study suggests the HH as inhibitor of UV-B-induced pigmentation, and depigmenting agent.

stripping of uranium from DEHPA/TOPO solvent by ammonium carbonate solutions

International Nuclear Information System (INIS)

Khorfan, S.; Shino, O.; Wahood, A.; Dahdouh, A.

2002-01-01

Uranium is recovered from phosphoric acid by the DEHPA/TOPO process. In this process uranium is stripped from the loaded DEHPA/TOPO solvent in the second cycle by an ammonium carbonate solution. This paper studied stripping of uranium from 0.3 Mol DEHPA/0.075 Mol TOPO in kerosene by different ammonium carbonate solutions. The ammonium carbonate solutions tested were either made locally from ammonia and carbon dioxide gases or commercial and laboratory grades available on the market. A comparison was made between these carbonate solutions in terms of purity, stripping efficiency and phase separation. Both stripping and phase separation were carried out under different conditions of phase ratio and concentrations. The results obtained showed that ammonium carbonate prepared from direct synthesis of ammonia and carbon dioxide gases had a high purity and gave the same stripping yield as the laboratory grade. The phase separation was also slightly improved using a pure synthesized ammonium carbonate solution. the phase separation was found to be best at concentration of 0.5 Mol/L ammonium carbonate solution and at a phase A/O of 1/1 and a temperature of 50 degree centigrade. It was possible to obtain >99% yield by operating 2 stripping stages counter currently under these conditions. (authors)

Anatomia de espécies anfíbias de Cyperaceae de lagoas do semi-árido, BA, Brasil Anatomy of amphibious Cyperaceae species from lakes in the semi-arid region of Bahia State, Brazil

Directory of Open Access Journals (Sweden)

Kelly Regina Batista Leite

2009-09-01

Full Text Available Foi estudada a anatomia de raízes, rizomas, folhas e escapos de Cyperus odoratus L., Oxycaryum cubense (Poep. & Kunth Lye e Pycreus macrostachyos (Lam. Raynal (Cyperaceae-Poales de lagoas do semi-árido da Bahia visando caracterizar anatomicamente as espécies e levantar estruturas adaptativas à forma de vida anfíbia. As espécies apresentam raízes com epiderme unisseriada, córtex com exoderme e lacunas de ar. Os rizomas apresentam feixes vasculares anfivasais ou colaterais no cilindro vascular. As folhas apresentam epiderme unisseriada, com células de parede periclinal externa mais espessada que a interna, estômatos somente na face abaxial, parênquima clorofiliano alternado com lacunas de ar e feixes vasculares colaterais. Os escapos apresentam epiderme unisseriada, feixes de fibras distribuídos perifericamente alternados com parênquima clorofiliano, lacunas de ar e feixes vasculares colaterais. Oxycaryum cubense difere de Cyperus odoratus e Pycreus macrostachyos por apresentar raízes com pêlos longos, rizomas e estolões com feixes vasculares colaterais, folhas com bordo agudo, e ausência de estrutura Kranz nas folhas e escapos. Características anatômicas como: lacunas de ar observadas principalmente nas raízes, células buliformes na face adaxial da epiderme foliar, hipoderme, reduzido número de elementos xilemáticos e pouca lignificação nas paredes celulares dos tecidos nos diferentes órgãos estudados são consideradas importantes na adaptação dessas plantas anfíbias às lagoas temporárias do semi-árido da Bahia.We examined the anatomy of roots, rhizomes, leaves, and scapes of Cyperus odoratus L., Oxycaryum cubense (Poep. & Kunth Lye, and Pycreus macrostachyos (Lam. Raynal (Cyperaceae-Poales from temporary lakes in the semi-arid region of Bahia in order to characterize the anatomy and examine structural adaptations to amphibious lifestyle. All species had roots with uniseriate epidermal cells, cortex with exoderm

Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling.

Directory of Open Access Journals (Sweden)

David Judah

Full Text Available Integrin-linked kinase (ILK is an important scaffold protein that mediates a variety of cellular responses to integrin stimulation by extracellular matrix proteins. Mice with epidermis-restricted inactivation of the Ilk gene exhibit pleiotropic phenotypic defects, including impaired hair follicle morphogenesis, reduced epidermal adhesion to the basement membrane, compromised epidermal integrity, as well as wasting and failure to thrive leading to perinatal death. To better understand the underlying molecular mechanisms that cause such a broad range of alterations, we investigated the impact of Ilk gene inactivation on the epidermis transcriptome. Microarray analysis showed over 700 differentially regulated mRNAs encoding proteins involved in multiple aspects of epidermal function, including keratinocyte differentiation and barrier formation, inflammation, regeneration after injury, and fundamental epidermal developmental pathways. These studies also revealed potential effects on genes not previously implicated in ILK functions, including those important for melanocyte and melanoblast development and function, regulation of cytoskeletal dynamics, and homeobox genes. This study shows that ILK is a critical regulator of multiple aspects of epidermal function and homeostasis, and reveals the previously unreported involvement of ILK not only in epidermal differentiation and barrier formation, but also in melanocyte genesis and function.

Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling.

Science.gov (United States)

Judah, David; Rudkouskaya, Alena; Wilson, Ryan; Carter, David E; Dagnino, Lina

2012-01-01

Integrin-linked kinase (ILK) is an important scaffold protein that mediates a variety of cellular responses to integrin stimulation by extracellular matrix proteins. Mice with epidermis-restricted inactivation of the Ilk gene exhibit pleiotropic phenotypic defects, including impaired hair follicle morphogenesis, reduced epidermal adhesion to the basement membrane, compromised epidermal integrity, as well as wasting and failure to thrive leading to perinatal death. To better understand the underlying molecular mechanisms that cause such a broad range of alterations, we investigated the impact of Ilk gene inactivation on the epidermis transcriptome. Microarray analysis showed over 700 differentially regulated mRNAs encoding proteins involved in multiple aspects of epidermal function, including keratinocyte differentiation and barrier formation, inflammation, regeneration after injury, and fundamental epidermal developmental pathways. These studies also revealed potential effects on genes not previously implicated in ILK functions, including those important for melanocyte and melanoblast development and function, regulation of cytoskeletal dynamics, and homeobox genes. This study shows that ILK is a critical regulator of multiple aspects of epidermal function and homeostasis, and reveals the previously unreported involvement of ILK not only in epidermal differentiation and barrier formation, but also in melanocyte genesis and function.

Compton recoil electron tracking with silicon strip detectors

International Nuclear Information System (INIS)

O'Neill, T.J.; Ait-Ouamer, F.; Schwartz, I.; Tumer, O.T.; White, R.S.; Zych, A.D.

1992-01-01

The application of silicon strip detectors to Compton gamma ray astronomy telescopes is described in this paper. The Silicon Compton Recoil Telescope (SCRT) tracks Compton recoil electrons in silicon strip converters to provide a unique direction for Compton scattered gamma rays above 1 MeV. With strip detectors of modest positional and energy resolutions of 1 mm FWHM and 3% at 662 keV, respectively, 'true imaging' can be achieved to provide an order of magnitude improvement in sensitivity to 1.6 x 10 - 6 γ/cm 2 -s at 2 MeV. The results of extensive Monte Carlo calculations of recoil electrons traversing multiple layers of 200 micron silicon wafers are presented. Multiple Coulomb scattering of the recoil electron in the silicon wafer of the Compton interaction and the next adjacent wafer is the basic limitation to determining the electron's initial direction

Standardized method to obtain dermo-epidermal junction samples from bovine hoof

Directory of Open Access Journals (Sweden)

H.M.F. Mendes

2015-04-01

Full Text Available As afecções podais em bovinos causam importante impacto econômico negativo na bovinocultura. Pesquisas têm sido realizadas com o objetivo de avançar no entendimento dos processos ocorridos na junção derme-epiderme do casco de bovinos com laminite e nos demais tecidos moles durante as lesões infecciosas. Apesar disso, não foram encontrados na literatura consultada estudos que descrevessem um método padronizado para a obtenção de amostras do tecido laminar do casco. Nesse contexto, foi necessário criar e estabelecer um método viável para a colheita de amostras da junção derme-epiderme, de modo a viabilizar o estudo de pós-graduação que originou esta comunicação. O objetivo é relatar um método padronizado, testado e bem-sucedido para obtenção de amostras da junção derme-epiderme do casco de bovinos em suas regiões solear, axial e dorsal. Foram obtidos fragmentos transversais das unhas de vacas abatidas em frigorífico. A espessura desses fragmentos foi de 1,5cm, aproximadamente, e contemplava as regiões solear, axial e dorsal do casco. De forma sistematizada, amostras da junção derme-epiderme de cada uma dessas regiões foram removidas, fixadas em formol, processadas e incluídas em parafina. A análise usando microscopia de luz demonstrou cortes histológicos íntegros e sem artefatos, que permitiram ampla avaliação das estruturas tanto da derme quanto da epiderme. Concluiu-se que o método proposto viabiliza a obtenção de amostras de padrão e qualidade adequados ao estudo do tecido laminar do casco bovino.

The Analysis of a Wideband Strip-Helical Antenna with 1.1 Turns

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Xihui Tang

2016-01-01

Full Text Available A wideband strip-helical antenna with 1.1 turns is analyzed numerically and experimentally. By replacing the traditional wire helix with wide metallic strip, the forward traveling current on the strip helix with about one turn smoothly decays to the minimum value at the open end of the helix. Therefore, the strip helix can excite a wideband circular polarization (CP wave with 50-ohm impedance matching. The proposed antenna is printed on a hollow-cylinder with a substrate relative permittivity of εr=2.2 and a thickness of h=0.5 mm. A 50 Ω coaxial cable is directly connected to excite the strip-helical antenna without any additional impedance matching section. The ground plane is placed below the antenna in order to provide a directional radiation pattern. To demonstrate this method, a prototype of 1.1-turn strip-helical antenna is tested. The test shows that the proposed antenna can reach an overlapped bandwidth of 46% with height of 0.52λ0, where λ0 is the wavelength in free space at the center operation frequency.

Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

CERN Document Server

Garcia-Argos, Carlos; The ATLAS collaboration

2017-01-01

The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas on the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

CERN Document Server

Garcia-Argos, Carlos; The ATLAS collaboration

2017-01-01

The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas in the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

Dual deflectable beam strip engine development.

Science.gov (United States)

Dulgeroff, C. R.; Zuccaro, D. E.; Kami, S.; Schnelker, D. E.; Ward, J. W.

1972-01-01

This paper describes a dual beam thruster that has been designed, constructed, and tested. The system is suitable for two-axes attitude control and is comprised of two orthogonal strips, each capable of producing 0.30 mlb thrust and beam deflections of more than plus or minus 20 deg. The nominal specific impulse for the thruster is 5000 sec, and the thrust level from each strip can be varied from 0 to 100%. Neutralizer filaments that were developed and life tested over 2000 hours producing more than 40 mA of electron emission per watt of input power are also discussed. The system power required for clean ionizers is approximately 200 W.

PECULIAR FEATURES PERTAINING TO STRIP FORMATION FROM BAR

Directory of Open Access Journals (Sweden)

G. N. Zdor

2010-01-01

Full Text Available The paper describes results of calculations and presents experimental substantiation of the dependence of a strip width being rolled out of a 10-mm diameter bar on its final thickness. It has been shown that the formation technology of thin steel strips out of a round bar makes it possible without any difficulties to obtain rolled products with the given cross-section dimensions due to proper selection of single drafting.

Improvement of arbutin trans-epidermal delivery using ...

African Journals Online (AJOL)

Purpose: To assess the ability of radiofrequency (RF) microporation to promote trans-epidermal delivery of arbutin. Methods: To investigate the enhancing effect of RF microchannels on skin permeation of arbutin, in vitro skin permeability studies were performed with RF microporation-treated Hartley albino guinea pig skin ...

Laser stripping of relativistic H- ions with practical considerations

International Nuclear Information System (INIS)

Tomlin, R.

1995-12-01

This paper describes laser stripping of H - ions. Some applications are suggested for HEP including stripping 2GeV ions circulating in an accelerator with radius 75 meters where laser meets ion head on in a three meter interaction region. The paper describes photoionizaton cross section, laser power calculation, and how to generate the 5 micrometer light

The Las Vegas Strip as a Genuinely Invented Global Landscape

Directory of Open Access Journals (Sweden)

Daniel Ortega

2004-12-01

Full Text Available Las Vegas, Nevada, is typically recognised as a place via a single urban gesture, that gesture being Las Vegas Boulevard, which is more commonly referred to as "The Strip". In constructing a thesis around the theme, "Here or There? Interconnections between the Global and the Local", one cannot ignore the invitation to discuss globalisation and its effects on a particular local fabric. For the purpose of this text, globalisation can be thought of as what Carmona et al describe as an intricate series of events leading to the world "becoming increasingly interconnected, with centralised decision making exploiting economies of scale and standardisation" (2003: 101. The centralised decision-making process for The Strip is evident in the strategy to develop individually themed casino resorts along Las Vegas Boulevard that respond to a competitive economy, thus creating a newly standardised landscape. If we also understand that globalisation can be thought of as the development of an interconnected world where economic, political and cultural boundaries can be easily crossed, this work can begin to define how the Las Vegas Strip is a genuinely invented global landscape. This paper addresses the "here-ness" as well as the "there-ness" of The Strip, while offering a dialectical framework for establishing a meaning of place by having 'there' placed 'here'. By employing semiological interpretations of real landscapes from around the globe (for example, Venturi et al, 1972, The Strip becomes a newly invented landscape of "simulations" (Baudrillard, 1988. As such, The Strip acts as a narrative that forms a unique place, opening the door to questions of authenticity and identity. This paper concludes by focusing on the question of "Here or There?" as an appropriate deviation from the assumed role that the post-modern landscape of the Las Vegas Strip plays. This work is intended to be a point of departure from the frequent criticism of the Las Vegas Strip as

Epidermal characters of Tamarix L. (Tamaricaceae from Northwest China and their taxonomic and palaeogeographic implications

Directory of Open Access Journals (Sweden)

Jian-Wei Zhang

2018-04-01

Full Text Available The taxonomical position of species of the genus Tamarix (Tamaricaceae has been criticized because of their gross morphological similarities (such as slender, smooth and reddish–brown branches, grey–green foliage and scale leaves, and their systematic relationships remain unclear. In this paper, the leaf epidermal features of 17 species from China are studied based on the micro-morphological characters of the epidermal cells, stomata, salt glands, papillae and epidermal hairs. According to the studies, the leaf epidermal features, together with the character of the flower, are taxonomically clearly distinct. The establishment of Tamarix albiflonum is consolidated. Tamarix korolkowi and Tamarix ramosissima have minimal differences in epidermal characters, and the former is suggested to be a junior synonym. Tamarix ramosissima, Tamarix tarimensis, Tamarix arceuthoides and Tamarix hohenackeri are most similar with respect to their leaf epidermis; considering the common morphological features, habit, distribution and especially the hybridization, it is suggested that these four species are closely genetically related and that the variations among them are probably intraspecific. The new taxonomical evidence indicates the occurrence of 13 species and four variants in China. Presently, Tamarix is a typical plant of arid and semi-arid regions, but its Eocene ancestors lived in warm and humid climates in the coastal areas of the ancient Mediterranean Sea. Thus, the papillae or epidermal hairs, which are outgrowths of the outer epidermal cells facilitating the leaf to respond to water stress and commonly seen in the plants growing in arid or semi-arid areas rather than the plants in warm and humid climates, are of relatively recent origin in Tamarix. The primitive species lack papillae or epidermal hairs, while in evolved species these structures are abundant. Based on the ecological adaptations of the epidermal features, the palaeogeographic

Flexible Faraday Cage with a Twist: Surface Charge on a Mobius Strip

Science.gov (United States)

Stewart, Sean

2007-01-01

Once an intriguing topological novelty known only to mathematicians, the Mobius strip has become a source of fascination and inspiration to the layperson and artist alike. Principal among its features are the two strange properties that the Mobius strip is a surface with only one side and one edge. A Mobius strip is readily formed by taking a long…

Hybrid Enhanced Epidermal SpaceSuit Design Approaches

Science.gov (United States)

Jessup, Joseph M.

A Space suit that does not rely on gas pressurization is a multi-faceted problem that requires major stability controls to be incorporated during design and construction. The concept of Hybrid Epidermal Enhancement space suit integrates evolved human anthropomorphic and physiological adaptations into its functionality, using commercially available bio-medical technologies to address shortcomings of conventional gas pressure suits, and the impracticalities of MCP suits. The prototype HEE Space Suit explored integumentary homeostasis, thermal control and mobility using advanced bio-medical materials technology and construction concepts. The goal was a space suit that functions as an enhanced, multi-functional bio-mimic of the human epidermal layer that works in attunement with the wearer rather than as a separate system. In addressing human physiological requirements for design and construction of the HEE suit, testing regimes were devised and integrated into the prototype which was then subject to a series of detailed tests using both anatomical reproduction methods and human subject.

Grhl3 and Lmo4 play coordinate roles in epidermal migration.

Science.gov (United States)

Hislop, Nikki R; Caddy, Jacinta; Ting, Stephen B; Auden, Alana; Vasudevan, Sumitha; King, Sarah L; Lindeman, Geoffrey J; Visvader, Jane E; Cunningham, John M; Jane, Stephen M

2008-09-01

In addition to its role in formation of the epidermal barrier, the mammalian transcription factor Grainy head-like 3 (Grhl3) is also essential for neural tube closure and wound repair, processes that are dependent in part on epidermal migration. Here, we demonstrate that the LIM-only domain protein, LMO4 serves as a functional partner of GRHL3 in its established roles, and define a new cooperative role for these factors in another developmental epidermal migration event, eyelid fusion. GRHL3 and LMO4 interact biochemically and genetically, with mutant mice exhibiting fully penetrant exencephaly, thoraco-lumbo-sacral spina bifida, defective skin barrier formation, and a co-incident eyes-open-at-birth (EOB) phenotype, which is not observed in the original individual null lines. The two genes are co-expressed in the surface ectoderm of the migrating eyelid root, and electron microscopy of Grhl3/Lmo4-null eyes reveals a failure in epithelial extension and a lack of peridermal clump formation at the eyelid margins. Accumulation of actin fibers is also absent in the circumference of these eyelids, and ERK1/2 phosphorylation is lost in the epidermis and eyelids of Grhl3(-/-)/Lmo4(-/-) embryos. Keratinocytes from mutant mice fail to "heal" in in vitro scratch assays, consistent with a general epidermal migratory defect that is dependent on ERK activation and actin cable formation.

Transfer printing of graphene strip from the graphene grown on copper wires

International Nuclear Information System (INIS)

Su, Ching-Yuan; Fu Dongliang; Lu, Ang-Yu; Liu, Keng-Ku; Xu Yanping; Juang, Zhen-Yu; Li, Lain-Jong

2011-01-01

A simple, cost-effective and lithography-free fabrication of graphene strips for device applications is demonstrated. The graphene thin layers were directly grown on Cu wires, followed by Cu etching and transfer printing to arbitrary substrates by a PDMS stamp. The Cu wires can be arranged on the PDMS stamp in a desired pattern; hence, the substrates can receive graphene strips with the same pattern. Moreover, the preparation of graphene strips does not involve conventional lithography; therefore, the surface of the graphene strip is free of residual photoresists, which may be useful for studies requiring clean graphene surfaces.

Theoretical study of H- stripping with a wiggler magnet

International Nuclear Information System (INIS)

Hutson, R.L.

1991-01-01

The first step for injecting protons into the LAMPF Proton Storage Ring (PSR) at LANL is to strip a beam of 800-MeV H - ions to H 0 with a 1.8-T dipole magnet. Because of the finite lifetime of energetic H - ions in the magnetic field, their trajectories bend before stripping causing the angular spread of the beam, and therefore its emittance, to grow during the stripping process. In the case of the PSR, the horizontal beam emittance grows by a factor of roughly three during injection. As a consequence, beam losses in the ring are significantly greater than they would be if there were not emittance growth. A speculative technique is proposed in which the beam divergence growth and resulting emittance growth is reduced by stripping the H - in a wiggler magnet whose transverse field alternates in direction as a function of position along the beam axis. The wiggler field configuration is adjusted so that the angular beam spread introduced during passage through one unidirectional-field increment of path is relatively small and so that 99.99% of the beam is stripped after passing through the whole magnet. With careful field design the net added angular beam spread is reduced because the incremental angular spreads are painted back and forth over the same small range. In the hypothetical case described, the calculated emittance growth and beam loss increase are significantly smaller than those calculated for a conventional stripper magnet. 3 refs., 3 figs

Coordinate determination of high energy charged particles by silicon strip detectors

International Nuclear Information System (INIS)

Anokhin, I.E.; Zinets, O.S.

2002-01-01

The coordinate determination accuracy of minimum ionizing and short-range particles by silicon strip detectors has been considered. The charge collection on neighboring strips of the detector is studied and the influence of diffusion and the electric field distribution on the accuracy of the coordinate determination is analyzed. It has been shown that coordinates of both minimum ionizing and short-range particles can be determined with accuracy to a few microns using silicon strip detectors. 11 refs.; 8 figs

Fabrication of silicon strip detectors using a step-and-repeat lithography system

International Nuclear Information System (INIS)

Holland, S.

1991-11-01

In this work we describe the use of a step-and-repeat lithography system (stepper) for the fabrication of silicon strip detectors. Although the field size of the stepper is only 20 mm in diameter, we have fabricated much larger detectors by printing a repetitive strip detector pattern in a step-and-repeat fashion. The basic unit cell is 7 mm in length. The stepper employs a laser interferometer for stage placement, and the resulting high precision allows one to accurately place the repetitive patterns on the wafer. A small overlap between the patterns ensures a continuous strip. A detector consisting of 512 strips on a 50 μm pitch has been fabricated using this technique. The dimensions of the detector are 6.3 cm by 2.56 cm. Yields of over 99% have been achieved, where yield is defined as the percentage of strips with reverse leakage current below 1 nA. In addition to the inherent advantages of a step-and-repeat system, this technique offers great flexibility in the fabrication of large-area strip detectors since the length and width of the detector can be changed by simply reprogramming the stepper computer. Hence various geometry strip detectors can be fabricated with only one set of masks, as opposed to a separate set of masks for each geometry as would be required with a contact or proximity aligner

Moving strip technique of electron beam therapy

Energy Technology Data Exchange (ETDEWEB)

Matsushima, Kishio; Wakasa, Hiroyuki; Oguri, Nobuhiro; Kitayama, Takuichi; Nakagiri, Yoshitada; Mikami, Yasutaka; Hashimoto, Keiji; Hiraki, Yoshio; Aono, Kaname

1984-12-01

The fieldsize in electron beam therapy is determined by the cone size. In case of skin metastasis of a malignant tumor and so on, which need a large field size and whose area is much larger than the size of the cone, a large field size is usually produced by dividing the portals. However, the dose distribution at the border of the field becomes unequal, and hot and cold dose areas are produced according to the distance between portals. We tried the strip field technique in a large field along the long axis of the body in order to flatten the dose of the border employing the moving strip used for whole abdominal irradiation in ovarian cancer. We set the film in Mix-DP and used the strip field technique with 2.5cm steps. We discussed the relationship between the interval (distance between portals) and the flattening of the dose within the field. Skin movement due to breathing and influences on the flattening of the dose were considered. The proper flatness was obtained at depths of 0,1,2, and 3cm by setting the interval at 0.5cm. When skin movement was produced by breathing in +-1.5mm, the proper flaness was obtained also at a 0.5-cm interval. It seems that smoothing is increased by breathing. An ''electron beam moving strip'' with a 2.5-cm step and 0.5-cm interval was clinically effective in the treatment of patients with skin metastasis of colon cancer. (author).

THz Wave Propagation on Strip Lines: Devices, Properties, and Applications

Directory of Open Access Journals (Sweden)

Y. Kadoya

2008-06-01

Full Text Available We report the propagation characteristics of THz pulses on micro-strip-lines and coplanar strip-lines, in which low permittivity polymer materials are used as the dielectric layer or the substrate. As a result of the low attenuation and small dispersion in the devices, the spectral width up to 3 THz can be achieved even after the 1 mm propagation. Spectroscopic characterizations of liquid or powder specimens are demonstrated using the devices. We also show a possibility of realizing a very low attenuation using a quadrupole mode in three strip coplanar lines on the polymer substrate.

Improved dielectric functions in metallic films obtained via template stripping

Science.gov (United States)

Hyuk Park, Jong; Nagpal, Prashant; Oh, Sang-Hyun; Norris, David J.

2012-02-01

We compare the dielectric functions of silver interfaces obtained via thermal evaporation with those obtained with template stripping. Ellipsometry measurements show that the smoother template-stripped surfaces exhibit effective dielectric functions with a more negative real component and a smaller imaginary component, implying higher conductivity and less energy loss, respectively. These results agree with the relation between dielectric function and surface roughness derived from combining the effective-medium model and the Drude-Lorentz model. The improvement in the effective dielectric properties shows that metallic films prepared via template stripping can be favorable for applications in electronics, nanophotonics, and plasmonics.

New technology for the production of magnesium strips and sheets

Directory of Open Access Journals (Sweden)

R. Kawalla

2008-07-01

Full Text Available A new production technology for magnesium strip, based on twin-roll-casting and strip rolling was developed in Freiberg Germany. By means of this economic method it is possible to produce strips in deep drawing quality with good forming properties in order to satisfy the request for low cost Mg sheets in the automotive and electronic industry. Both, coils as single sheets, were manufactured and rolled to a thickness of 1mm(0,5 mm. The technology of the new process and the properties of the twin-roll-casted material and the final sheets are presented.

3D silicon strip detectors

International Nuclear Information System (INIS)

Parzefall, Ulrich; Bates, Richard; Boscardin, Maurizio; Dalla Betta, Gian-Franco; Eckert, Simon; Eklund, Lars; Fleta, Celeste; Jakobs, Karl; Kuehn, Susanne; Lozano, Manuel; Pahn, Gregor; Parkes, Chris; Pellegrini, Giulio; Pennicard, David; Piemonte, Claudio; Ronchin, Sabina; Szumlak, Tomasz; Zoboli, Andrea; Zorzi, Nicola

2009-01-01

While the Large Hadron Collider (LHC) at CERN has started operation in autumn 2008, plans for a luminosity upgrade to the Super-LHC (sLHC) have already been developed for several years. This projected luminosity increase by an order of magnitude gives rise to a challenging radiation environment for tracking detectors at the LHC experiments. Significant improvements in radiation hardness are required with respect to the LHC. Using a strawman layout for the new tracker of the ATLAS experiment as an example, silicon strip detectors (SSDs) with short strips of 2-3 cm length are foreseen to cover the region from 28 to 60 cm distance to the beam. These SSD will be exposed to radiation levels up to 10 15 N eq /cm 2 , which makes radiation resistance a major concern for the upgraded ATLAS tracker. Several approaches to increasing the radiation hardness of silicon detectors exist. In this article, it is proposed to combine the radiation hard 3D-design originally conceived for pixel-style applications with the benefits of the established planar technology for strip detectors by using SSDs that have regularly spaced doped columns extending into the silicon bulk under the detector strips. The first 3D SSDs to become available for testing were made in the Single Type Column (STC) design, a technological simplification of the original 3D design. With such 3D SSDs, a small number of prototype sLHC detector modules with LHC-speed front-end electronics as used in the semiconductor tracking systems of present LHC experiments were built. Modules were tested before and after irradiation to fluences of 10 15 N eq /cm 2 . The tests were performed with three systems: a highly focused IR-laser with 5μm spot size to make position-resolved scans of the charge collection efficiency, an Sr 90 β-source set-up to measure the signal levels for a minimum ionizing particle (MIP), and a beam test with 180 GeV pions at CERN. This article gives a brief overview of the results obtained with 3D-STC-modules.

3D silicon strip detectors

Energy Technology Data Exchange (ETDEWEB)

Parzefall, Ulrich [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany)], E-mail: ulrich.parzefall@physik.uni-freiburg.de; Bates, Richard [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Boscardin, Maurizio [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy); Dalla Betta, Gian-Franco [INFN and Universita' di Trento, via Sommarive 14, 38050 Povo di Trento (Italy); Eckert, Simon [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Eklund, Lars; Fleta, Celeste [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Jakobs, Karl; Kuehn, Susanne [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Lozano, Manuel [Instituto de Microelectronica de Barcelona, IMB-CNM, CSIC, Barcelona (Spain); Pahn, Gregor [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); Parkes, Chris [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Pellegrini, Giulio [Instituto de Microelectronica de Barcelona, IMB-CNM, CSIC, Barcelona (Spain); Pennicard, David [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Piemonte, Claudio; Ronchin, Sabina [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy); Szumlak, Tomasz [University of Glasgow, Department of Physics and Astronomy, Glasgow G12 8QQ (United Kingdom); Zoboli, Andrea [INFN and Universita' di Trento, via Sommarive 14, 38050 Povo di Trento (Italy); Zorzi, Nicola [FBK-irst, Center for Materials and Microsystems, via Sommarive 18, 38050 Povo di Trento (Italy)

2009-06-01

While the Large Hadron Collider (LHC) at CERN has started operation in autumn 2008, plans for a luminosity upgrade to the Super-LHC (sLHC) have already been developed for several years. This projected luminosity increase by an order of magnitude gives rise to a challenging radiation environment for tracking detectors at the LHC experiments. Significant improvements in radiation hardness are required with respect to the LHC. Using a strawman layout for the new tracker of the ATLAS experiment as an example, silicon strip detectors (SSDs) with short strips of 2-3 cm length are foreseen to cover the region from 28 to 60 cm distance to the beam. These SSD will be exposed to radiation levels up to 10{sup 15}N{sub eq}/cm{sup 2}, which makes radiation resistance a major concern for the upgraded ATLAS tracker. Several approaches to increasing the radiation hardness of silicon detectors exist. In this article, it is proposed to combine the radiation hard 3D-design originally conceived for pixel-style applications with the benefits of the established planar technology for strip detectors by using SSDs that have regularly spaced doped columns extending into the silicon bulk under the detector strips. The first 3D SSDs to become available for testing were made in the Single Type Column (STC) design, a technological simplification of the original 3D design. With such 3D SSDs, a small number of prototype sLHC detector modules with LHC-speed front-end electronics as used in the semiconductor tracking systems of present LHC experiments were built. Modules were tested before and after irradiation to fluences of 10{sup 15}N{sub eq}/cm{sup 2}. The tests were performed with three systems: a highly focused IR-laser with 5{mu}m spot size to make position-resolved scans of the charge collection efficiency, an Sr{sup 90}{beta}-source set-up to measure the signal levels for a minimum ionizing particle (MIP), and a beam test with 180 GeV pions at CERN. This article gives a brief overview of

Bimetallic strip for low temperature use. [4-300/sup 0/K

Science.gov (United States)

Bussiee, J.F.; Welch, D.O.; Suenaga, M.

A class of mechanically pre-stressed structures is provided suitably bi-layer strips, consisting of a layer of group 5 transition metals in intimate contact with a layer of an intermetallic compound of transition metals with certain group 3A, 4A or 5A metals or metalloids such as Ga, In, Si, Ge, Sn, As or Sb. The changes of Young's modulus of these bi-layered combinations at temperatures in the region of somewhat above absolute zero provides a useful means of sensing temperature changes. Such bi-metallic strips may be used as control strips in thermostats, or in direct dial reading instruments. The structures are made by preparing a sandwich of a group 5B transition metal strip between the substantially thicker strips of an alloy between copper and a predetermined group 3A, 4A or 5A metal or metalloid, holding the three layers are heated, cooled the copper alloys and is removed. Removing one of the two formed interlayer alloys between the transition metal and the metal previously alloyed with copper remain.

Buffer Strips for Riparian Zone Management

National Research Council Canada - National Science Library

1991-01-01

This study provides a review of technical literature concerning the width of riparian buffer strips needed to protect water quality and maintain other important values provided by riparian ecosystem...

L-strip proximity fed ga

Directory of Open Access Journals (Sweden)

Ashish Singh

2014-03-01

Full Text Available In this article, the analysis of dualband L-strip fed compact semi-circular disk microstrip patch antenna has been presented using circuit theory concept. The antenna parameters such as return loss, VSWR and radiation pattern are calculated. The effect of geometric dimensions of the proposed antenna such as length of vertical and horizontal portion of L-strip is investigated. It is found that antenna resonate at two distinct modes i.e. 1.3 GHz and 6.13 GHz for lower and upper resonance frequencies respectively. The bandwidth of the proposed antenna at lower resonance frequency is 6.61% (simulated and 10.64% (theoretical whereas at upper resonance frequency, it is 6.02% (simulated and 9.06 % (theoretical. The theoretical results are compared with IE3D simulation results as well as experimental results and they are in close agreement.

On the Formation of Ultra-Difuse Galaxies as Tidally-Stripped Systems

Science.gov (United States)

Carleton, Timothy; Cooper, Michael; Kaplinghat, Manoj; Errani, Raphael; Penarrubia, Jorge

2018-01-01

The recent identification of a large population of so-called 'Ultra-Diffuse' Galaxies (UDGs), with stellar masses ~108 M⊙, but half light radii over 1.5 kpc, has challenged our understanding of galaxy evolution. Motivated by the environmental dependence of UDG properties and abundance, I present a model for the formation of UDGs through tidal-stripping of dwarf galaxies in cored dark matter halos. To test this scenario, I utilize results from simulations of tidal stripping, which demonstrate that changes in the stellar profile of a tidally stripped galaxy can be written as a function of the amount of tidal stripping experienced by the halo (tidal tracks). These tracks, however, are different for cored and cuspy halos. Additional simulations show how the halo responds to tidal interactions given the halo orbit within a cluster.In particular, dwarf elliptical galaxies, born in 1010-10.5 M⊙ halos, expand significantly as a result of tidal stripping and produce UDGs. Applying these models to the population of halos in the Bolshoi simulation, I am able to follow the effects of tidal stripping on the dwarf galaxy population in clusters. Using tidal tracks for cuspy halos does not reproduce the observed properties of UDGs. However, using the tidal tracks for cored halos, I reproduce the distribution of sizes, stellar masses, and abundance of UDGs in clusters remarkably well.

Approaching total absorption of graphene strips using a c-Si subwavelength periodic membrane

Science.gov (United States)

Sang, Tian; Wang, Rui; Li, Junlang; Zhou, Jianyu; Wang, Yueke

2018-04-01

Approaching total absorption of graphene strips at near infrared using a crystalline-silicon (c-Si) subwavelength periodic membrane (SPM) is presented. The absorption in graphene strips in a c-Si SPM is enhanced by a resonant tip, which is resulted from the coupling between the guided mode and the radiation mode through symmetry breaking of the structure at near-normal incidence. The enhancement of the electric field intensity is increased 1939 times and the group velocity of light is decreased to 3.55 ×10-4c at resonance, and 99.3% absorption in graphene strips can be achieved by critical coupling at the incident angle of 2°. High absorption of the graphene strips can be maintained as the etching thickness, the strip width, and the period are altered. When this type of c-Si SPM with graphene strips is used in refractive index sensors, it shows excellent sensing properties due to its stable near-unity absorption.

Ammonia removal from landfill leachate by air stripping and absorption.

Science.gov (United States)

Ferraz, Fernanda M; Povinelli, Jurandyr; Vieira, Eny Maria

2013-01-01

An old landfill leachate was pre-treated in a pilot-scale aerated packed tower operated in batch mode for total ammoniacal nitrogen (TAN) removal. The stripped ammonia was recovered with a 0.4 mol L(-1) H2SO4 solution, deionized water and tap water. Ca(OH)2 (95% purity) or commercial hydrated lime was added to the raw leachate to adjust its pH to 11, causing removal of colour (82%) and heavy metals (70-90% for Zn, Fe and Mn). The 0.4 molL(-1) H2SO4 solution was able to neutralize 80% of the stripped ammonia removed from 12 L of leachate. The effectiveness of the neutralization of ammonia with deionized water was 75%. Treating 100 L of leachate, the air stripping tower removed 88% of TAN after 72 h of aeration, and 87% of the stripped ammonia was recovered in two 31 L pilot-scale absorption units filled with 20 L of tap water.

The New Silicon Strip Detectors for the CMS Tracker Upgrade

CERN Document Server

Dragicevic, Marko

2010-01-01

The first introductory part of the thesis describes the concept of the CMS experiment. The tasks of the various detector systems and their technical implementations in CMS are explained. To facilitate the understanding of the basic principles of silicon strip sensors, the subsequent chapter discusses the fundamentals in semiconductor technology, with particular emphasis on silicon. The necessary process steps to manufacture strip sensors in a so-called planar process are described in detail. Furthermore, the effects of irradiation on silicon strip sensors are discussed. To conclude the introductory part of the thesis, the design of the silicon strip sensors of the CMS Tracker are described in detail. The choice of the substrate material and the complex geometry of the sensors are reviewed and the quality assurance procedures for the production of the sensors are presented. Furthermore the design of the detector modules are described. The main part of this thesis starts with a discussion on the demands on the ...

Digital simulation of anodic stripping voltammetry from thin film electrodes

International Nuclear Information System (INIS)

Magallanes, J.F.

1984-01-01

The anodic stripping voltammetry (ASV) is routinely applied to control of Cu(II) in heavy water in the primary cooling loop of the Nuclear Power Reactor. The anodic stripping voltammetry (ASV) is a very well-known technique in electroanalytical chemistry. However, due to the complexity of the phenomena, it is practised with the fundamentals of empiric considerations. A geometric model for the anodic stripping voltammetry (ASV) from thin film electrodes which can be calculated by explicit digital simulation method is proposed as a possibility of solving the electrochemically reversible, cuasi-reversible and irreversible reactions under linear potential scan and multiple potential scans. (Until now the analytical mathematical method was applied to reversible reactions). All the results are compared with analytical solutions and experimental results and it permits to conclude that the anodic stripping voltammetry (ASV) can be studied with the simplicity and potentialities of explicit digital simulation methods. (M.E.L.) [es

Excision of pyrimidine dimers from epidermal DNA and nonsemiconservative epidermal DNA synthesis following ultraviolet irradiation of mouse skin

International Nuclear Information System (INIS)

Bowden, G.T.; Trosko, J.E.; Shapas, B.G.; Boutwell, R.K.

1975-01-01

Pyrimidine dimer production and excision in epidermal DNA were studied at five different dose levels of ultraviolet light in the skin of intact mice. Dimer production increased with dose up to 50,400 ergs/sq mm. Approximately 30 percent of the thymine-containing dimers were excised by 24 hr after irradiation at three lower dose levels of ultraviolet light. Nonsemiconservative DNA replication in ultraviolet-irradiated mouse skin was shown to continue for at least 18 hr. The rate of nonsemiconservative replication decreased with time, but did so slowly. The initial rates of nonsemiconservative replication increased with ultraviolet light dose levels up to about 4200 ergs/sq mm, after which the initial rates were decreased. Semiconservative epidermal DNA synthesis was shown to be inhibited by hydroxyurea, but hydroxyurea had no effect on ultraviolet light-induced nonsemiconservative DNA replication. The observed pyrimidine dimer excision and nonsemiconservative DNA replication suggest that in the intact mouse the cells of the epidermis are capable of DNA excision repair after ultraviolet irradiation of mouse skin

Engineering test of stripping performance by multi-centrifugal contactors system for spent nuclear reprocessing

International Nuclear Information System (INIS)

Masayuki Takeuchi; Tadahiro Washiya; Hiroki Nakabayashi; Takashi Suganuma; Shinnichi Aose

2005-01-01

Japan Nuclear Cycle Development Institute (JNC) has been developing centrifugal contactors which are compact and high performance for solvent extraction process in industrial reprocessing plant. The stripping performance including equilibrium time for distribution and hydraulic behavior of the multi-centrifugal contactors were mainly evaluated by using uranium nitrite solution on engineering scale (10 kgHM/hr). In particular, the effects of feed temperature of stripping solution and O/A on the stripping performance were focused in this test. As results, no hydraulic problem such as overflow and entrainment were observed in multi-centrifugal contactors system through all conditions, and the uranium and acid concentrations showed desirable profiles which were nearly consistent with calculated one by MIXSET-X code. As to stripping performance, uranium leak concentration in solvent reached to less than 0.01 g/L, which is target of the stripping performance on this centrifugal contactors system, within nine stages on all conditions. It was also found that the effect of feed temperature of stripping solution (35 degree C → 60 degree C) or O/A (1.0→0.8) on stripping performance corresponds to distribution capacity of two contactors, respectively. The stage efficiency for a contactor was estimated as 97-98% on stripping stage. There were no uranium leaks (less than 40μg/L) in spent solvent discharged from the final stage. The profiles of uranium concentration in multi-contactors become stable within 10 minutes after the stripping test starting. In this way, it was demonstrated that the centrifugal contactors system has good stripping performance on engineering scale. (authors)

Adsorptive stripping voltammetric methods for determination of aripiprazole

Directory of Open Access Journals (Sweden)

Derya Aşangil

2012-06-01

Full Text Available Anodic behavior of aripiprazole (ARP was studied using electrochemical methods. Charge transfer, diffusion and surface coverage coefficients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorption-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in Britton–Robinson buffer (BR on glassy carbon electrode. Voltammetric methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were developed. Linearity range is found as from 11.4 μM (5.11 mg/L to 157 μM (70.41 mg/L without stripping mode and it is found as from 0.221 μM (0.10 mg/L to 13.6 μM (6.10 mg/L with stripping mode. Limit of detection (LOD was found to be 0.11 μM (0.05 mg/L in stripping voltammetry. Methods were successfully applied to assay the drug in tablets, human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%. Keywords: Adsorptive stripping voltammetry, Aripiprazole, Electrochemical behavior, Human serum and urine, Pharmaceuticals

Strip-till seeder for sugar beets

Directory of Open Access Journals (Sweden)

Peter Schulze Lammers

2014-06-01

Full Text Available Strip-till save costs by reducing tillage on the area of sugar beet rows only. The seeding system is characterized by a deep loosening of soil with a tine combined with a share and by following tools generating fine-grained soil as seed bed. In cooperation with the Kverneland company group Soest/Germany a strip tiller combined with precision seeder was designed and tested in field experiments. Tilling and seeding was performed in one path on fields with straw and mustard mulch. Even the plant development was slower as compared to conventional sawn sugar beets the yield was on equivalent level. Further field experiments are planned to attest constant yield, cost and energy efficiency of the seeding system.

Stevens–Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat

Directory of Open Access Journals (Sweden)

Roberta Sartori

2016-06-01

Full Text Available Case summary A 5-year-old, spayed female, indoor-only domestic shorthair cat was referred with an acute history of multifocal cutaneous and mucocutaneous erosive-ulcerative lesions and skin detachment. The lesions occurred on the seventh day of therapy with cefadroxil. Erosive-ulcerative and occasionally crusted lesions were apparent on the medial and lateral canthus of both eyes, ventral neck, abdomen, perivulvar region, periungual skin and medial aspect of the front and hindlimbs. Diffuse and severe exfoliation was present on the dorsum and tail base and in both external ear canals. The cat was also dehydrated, tachycardic and febrile. Histopathological examination revealed extensive epidermal ulceration, interface dermatitis with vacuolar degeneration, apoptosis at multiple epidermal levels and basal, suprabasal and spinous dermoepidermal detachment. The histopathological diagnosis was consistent with Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN. The recently reported Algorithm of Drug Causality in Epidermal Necrolysis (ALDEN, currently used in human medicine, was applied and a score of +6 was calculated; this supported the view that SJS/TEN in this cat was very likely to be associated with cefadroxil administration. Relevance and novel information This clinical communication reports cefadroxil as a very probable cause of SJS/TEN in a cat; the ALDEN was applied in this case and supported diagnosis.

Synchrotron applications of pixel and strip detectors at Diamond Light Source

International Nuclear Information System (INIS)

Marchal, J.; Tartoni, N.; Nave, C.

2009-01-01

A wide range of position-sensitive X-ray detectors have been commissioned on the synchrotron X-ray beamlines operating at the Diamond Light Source in UK. In addition to mature technologies such as image-plates, CCD-based detectors, multi-wire and micro-strip gas detectors, more recent detectors based on semiconductor pixel or strip sensors coupled to CMOS read-out chips are also in use for routine synchrotron X-ray diffraction and scattering experiments. The performance of several commercial and developmental pixel/strip detectors for synchrotron studies are discussed with emphasis on the image quality achieved with these devices. Examples of pixel or strip detector applications at Diamond Light Source as well as the status of the commissioning of these detectors on the beamlines are presented. Finally, priorities and ideas for future developments are discussed.

Epidermal characters of Tamarix L. (Tamaricaceae) from Northwest China and their taxonomic and palaeogeographic implications

OpenAIRE

Jian-Wei Zhang; Ashalata D'Rozario; Shi-Min Duan; Xi-Yong Wang; Xiao-Qing Liang; Bo-Rong Pan

2018-01-01

The taxonomical position of species of the genus Tamarix (Tamaricaceae) has been criticized because of their gross morphological similarities (such as slender, smooth and reddish–brown branches, grey–green foliage and scale leaves), and their systematic relationships remain unclear. In this paper, the leaf epidermal features of 17 species from China are studied based on the micro-morphological characters of the epidermal cells, stomata, salt glands, papillae and epidermal hairs. According to ...

Neuroprotective effect of Zhen Tian Wan on pial strip-induced ...

African Journals Online (AJOL)

ZTW significantly reduced the level of free radicals in pial stripped rats. ZTW can improve learning and memory function and it possess anti-oxidant activity. ZTW may be beneficial in the treatment of vascular dementia. Keywords: Zhen Tian Wan; pial strip; lesion; Memory; Morris water maze; free radicals ...

Scaling of ammonia stripping towers in the treatment of groundwater polluted by municipal solid waste landfill leachate: study of the causes of scaling and its effects on stripping performance

Directory of Open Access Journals (Sweden)

Paolo Viotti

2015-04-01

Full Text Available This paper documents the causes of the scaling of stripping towers used for the treatment of groundwater polluted by the leachate from an old municipal solid waste (MSW landfill in northern Italy. The effects of the scaling on the stripping performance are also reported. The whole process consists of a coagulation-flocculation pre-treatment at pH > 11, followed by an ammonia stripping stage, after heating the water to 38°C in order to improve removal efficiency. The stripped ammonia is recovered by absorption with sulfuric acid, producing a 30% solution of ammonium sulfate (reused as a base fertilizer. The effluent air stream is recirculated to the stripping towers (closed loop systems in order to avoid an excessive temperature drop inside the packings, mainly in winter, with consequent loss of efficiency and risk of icing. The progressive scaling of the packing has resulted in a loss of ammonia removal efficiency from an initial value of 98% (clean packing down to 80% after six months of continuous operation, necessitating a chemical cleaning. Optimum conditions for design and operation of the stripping process are also documented.

An analysis of stripping to isolated analog resonances

International Nuclear Information System (INIS)

Pessoa, E.F.; Toledo Piza, A.F.R. de.

1983-04-01

The Feshbach projection formalism is used to calculate the form factors for the (d,n) stripping process to isolated analog resonances. These are used in a standard DWBA stripping calculation in which the radial integration over all space is accomplished by including outerspace contributions evaluated along the complex contours of Vincent and Fortune. It turns out that the shape and magnitude of the predicted cross section is quite insensitive to the continuum proton wave emanating from the resonant residual state. (Author) [pt

Epidermal growth factor receptor: an independent predictor of survival in astrocytic tumors given definitive irradiation

International Nuclear Information System (INIS)

An Zhu; Shaeffer, James; Leslie, Susan; Kolm, Paul; El-Mahdi, Anas M.

1996-01-01

Purpose: To determine whether the expression of epidermal growth factor receptor (EGFR) protein was predictive of patient survival independently of other prognostic factors in astrocytic tumors. Methods and Materials: Epidermal growth factor receptor protein expression was investigated immunohistochemically in formalin-fixed, paraffin-embedded surgical specimens of 55 glioblastoma multiforme, 14 anaplastic astrocytoma, and 2 astrocytomas given definitive irradiation. We evaluated the relationship of EGFR protein expression and tumor grade, histologic features, age at diagnosis, sex, patient survival, and recurrence-free survival. Results: The percentage of tumor cells which were EGFR positive related to reduced survival by Cox regression analysis in both univariate (p = 0.0424) and multivariate analysis (p = 0.0016). Epidermal growth factor receptor positivity was the only 1 of 11 clinical and histological variables associated with decreased recurrence-free survival by either univariate (p = 0.0353) or multivariate (p = 0.0182) analysis. Epidermal growth factor receptor protein expression was not related to patient age, sex, or histologic features. Conclusion: Epidermal growth factor receptor positivity was a significant and independent prognostic indicator for overall survival and recurrence-free survival for irradiated patients with astrocytic gliomas

Study of surface properties of ATLAS12 strip sensors and their radiation resistance

Energy Technology Data Exchange (ETDEWEB)

Mikestikova, M., E-mail: mikestik@fzu.cz [Academy of Sciences of the Czech Republic, Institute of Physics, Na Slovance 2, 18221 Prague 8 (Czech Republic); Allport, P.P.; Baca, M.; Broughton, J.; Chisholm, A.; Nikolopoulos, K.; Pyatt, S.; Thomas, J.P.; Wilson, J.A. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Kierstead, J.; Kuczewski, P.; Lynn, D. [Brookhaven National Laboratory, Physics Department and Instrumentation Division, Upton, NY 11973-5000 (United States); Hommels, L.B.A. [Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Ullan, M. [Centro Nacional de Microelectronica (IMB-CNM, CSIC), Campus UAB-Bellaterra, 08193 Barcelona (Spain); Bloch, I.; Gregor, I.M.; Tackmann, K. [DESY, Notkestrasse 85, 22607 Hamburg (Germany); Hauser, M.; Jakobs, K.; Kuehn, S. [Physikalisches Institut, Universität Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg (Germany); and others

2016-09-21

A radiation hard n{sup +}-in-p micro-strip sensor for the use in the Upgrade of the strip tracker of the ATLAS experiment at the High Luminosity Large Hadron Collider (HL-LHC) has been developed by the “ATLAS ITk Strip Sensor collaboration” and produced by Hamamatsu Photonics. Surface properties of different types of end-cap and barrel miniature sensors of the latest sensor design ATLAS12 have been studied before and after irradiation. The tested barrel sensors vary in “punch-through protection” (PTP) structure, and the end-cap sensors, whose stereo-strips differ in fan geometry, in strip pitch and in edge strip ganging options. Sensors have been irradiated with proton fluences of up to 1×10{sup 16} n{sub eq}/cm{sup 2}, by reactor neutron fluence of 1×10{sup 15} n{sub eq}/cm{sup 2} and by gamma rays from {sup 60}Co up to dose of 1 MGy. The main goal of the present study is to characterize the leakage current for micro-discharge breakdown voltage estimation, the inter-strip resistance and capacitance, the bias resistance and the effectiveness of PTP structures as a function of bias voltage and fluence. It has been verified that the ATLAS12 sensors have high breakdown voltage well above the operational voltage which implies that different geometries of sensors do not influence their stability. The inter-strip isolation is a strong function of irradiation fluence, however the sensor performance is acceptable in the expected range for HL-LHC. New gated PTP structure exhibits low PTP onset voltage and sharp cut-off of effective resistance even at the highest tested radiation fluence. The inter-strip capacitance complies with the technical specification required before irradiation and no radiation-induced degradation was observed. A summary of ATLAS12 sensors tests is presented including a comparison of results from different irradiation sites. The measured characteristics are compared with the previous prototype of the sensor design, ATLAS07. - Highlights: �

AIS/DOE Technology Roadmap Program: Strip Casting: Anticipating New Routes To Steel Sheet

Energy Technology Data Exchange (ETDEWEB)

Prof. Alan W. Camb; Prof. Anthony Rollett

2001-08-31

To determine the potential for strip casting in the steel industry and to develop the fundamental knowledge necessary to allow the role of strip casting in the modern steel industry to be understood. Based upon a study of carbon steel strip castings that were either produced for the program at British Steel or were received from a pre-commercial production machine, the following conclusions were made. Strip casting of carbon steels is technically feasible for sheet material from slightly less than 1 mm thick to 3 mm thick, and, assuming that it is economically viable, it will be first applied in carbon steel markets that do not require stringent surface quality or extensive forming. The potential of strip casting as a casting process to be developed for steel castings is very high as the cast strip has some very novel characteristics. Direct cast carbon strip has better surface quality, shape and profile than any other casting process currently available. The more rapidly solidified structure of direct cast strip tends to be strong with low ductility; however, with adequate thermal treatment, it is possible to develop a variety of properties from the same grade. The process is more amenable at this time to production tonnages per year of the order of 500,000 tons and as such will first find niche type applications. This technology is an additional technology for steel production and will be in addition to, rather than a replacement for, current casting machines.

Effect of stimulation intensity and botulinum toxin isoform on rat bladder strip contractions.

Science.gov (United States)

Smith, Christopher P; Boone, Timothy B; de Groat, William C; Chancellor, Michael B; Somogyi, George T

2003-07-15

The present experiments compared the inhibitory effects of botulinum toxin A (BoNT-A) and botulinum toxin D (BoNT-D) on neurally evoked contractions of rat bladder strips. We examined the effect of fatigue (trains of 100 shocks at 20Hz every 20s for 10min) followed by non-fatigue stimulation (trains of 100 shocks at 20Hz every 100s for 20min) on the onset of effect and potency of the two toxins. For non-fatigue experiments, strips were untreated (n=4); or incubated with 1.36nM BoNT-A (n=4). During fatigue experiments, strips were untreated (n=5); or treated with either 1.36nM BoNT-A (n=6) or 0.8nM BoNT-D (n=6). In non-fatigue experiments, BoNT-A produced significant decreases in contractile area after 1h of stimulation compared to untreated strips (PD bladder strips, were statistically significant (PD-treated strips, as a significant reduction (PD) and untreated bladder strips responded similarly to atropine, suggesting that the effects of BoNT result from inhibition of both acetylcholine and ATP release. Our results demonstrate that BoNT-D may be a more effective agent to inhibit transmitter release from autonomic nerves of the rat lower urinary tract. Moreover, in our hands, non-fatigue stimulation is as effective as fatigue stimulation in inhibiting bladder strip contractions.

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus

Directory of Open Access Journals (Sweden)

Hassan Riad

2013-10-01

Full Text Available A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC have all been reported to develop from a verrucous epidermal nevus. CSCC has also been reported to arise from other nevoid lesions like a nevus comedonicus, porokeratosis, a sebaceous nevus, an oral sponge nevus and an ichthyosiform nevus with CHILD syndrome. Here we report a case of progressive poorly differentiated CSCC arising from a localized verrucous epidermal nevus, which caused both spinal cord and brain metastasis.

Silicon Strip Detectors for ATLAS at the HL-LHC Upgrade

CERN Document Server

Hara, K; The ATLAS collaboration

2012-01-01

present ATLAS silicon strip tracker (SCT) and transition radiation tracker(TRT) are to be replaced with new silicon strip detectors as part of the Inner Tracker System (ITK) for the Phase-II upgrade of the Large Hadron Collider, HL-LHC. We have carried out intensive R&D programs based on n+-on-p microstrip detectors to fabricate improved radiation hard strip detectors that can survive the radiation levels corresponding to the integrated luminosity of up to 3000 fb−1. We describe the main specifications for this year’s sensor fabrication and the related R&D results, followed by a description of the candidate schema for module integration.

Distillation and Air Stripping Designs for the Lunar Surface

Science.gov (United States)

Boul, Peter J.; Lange, Kevin E.; Conger, Bruce; Anderson, Molly

2009-01-01

Air stripping and distillation are two different gravity-based methods, which may be applied to the purification of wastewater on the lunar base. These gravity-based solutions to water processing are robust physical separation techniques, which may be advantageous to many other techniques for their simplicity in design and operation. The two techniques can be used in conjunction with each other to obtain high purity water. The components and feed compositions for modeling waste water streams are presented in conjunction with the Aspen property system for traditional stage distillation models and air stripping models. While the individual components for each of the waste streams will vary naturally within certain bounds, an analog model for waste water processing is suggested based on typical concentration ranges for these components. Target purity levels for the for recycled water are determined for each individual component based on NASA s required maximum contaminant levels for potable water Distillation processes are modeled separately and in tandem with air stripping to demonstrate the potential effectiveness and utility of these methods in recycling wastewater on the Moon. Optimum parameters such as reflux ratio, feed stage location, and processing rates are determined with respect to the power consumption of the process. Multistage distillation is evaluated for components in wastewater to determine the minimum number of stages necessary for each of 65 components in humidity condensate and urine wastewater mixed streams. Components of the wastewater streams are ranked by Henry s Law Constant and the suitability of air stripping in the purification of wastewater in terms of component removal is evaluated. Scaling factors for distillation and air stripping columns are presented to account for the difference in the lunar gravitation environment. Commercially available distillation and air stripping units which are considered suitable for Exploration Life Support

Simulation studies for the ATLAS upgrade Strip tracker

CERN Document Server

Wang, Jike; The ATLAS collaboration

2017-01-01

ATLAS is making extensive efforts towards preparing a detector upgrade for the High luminosity operations of the LHC (HL-LHC), which will commence operation in ~10 years. The current ATLAS Inner Detector will be replaced by a all-silicon tracker (comprising an inner Pixel tracker and outer Strip tracker). The software currently used for the new silicon tracker is broadly inherited from that used for the LHC Run 1 and 2, but many new developments have been made to better fulfil the future detector and operation requirements. One aspect in particular which will be highlighted is the simulation software for the Strip tracker. The available geometry description software (including the detailed description for all the sensitive elements, the services, etc.) did not allow for accurate modeling of the planned detector design. A range of sensors/layouts for the Strip tracker are being considered and must be studied in detailed simulations in order to assess the performance and ascertain that requirements are met. For...

Modi ed strip packing heuristics for the rectangular variable-sized ...

African Journals Online (AJOL)

Two packing problems are considered in this paper, namely the well-known strip packing problem (SPP) and the variable-sized bin packing problem (VSBPP). A total of 252 strip packing heuristics (and variations thereof) from the literature, as well as novel heuristics proposed by the authors, are compared statistically by ...

CLOSED-LOOP STRIPPING ANALYSIS (CLSA) OF ...

Science.gov (United States)

Synthetic musk compounds have been found in surface water, fish tissues, and human breast milk. Current techniques for separating these compounds from fish tissues require tedious sample clean-upprocedures A simple method for the deterrnination of these compounds in fish tissues has been developed. Closed-loop stripping of saponified fish tissues in a I -L Wheaton purge-and-trap vessel is used to strip compounds with high vapor pressures such as synthetic musks from the matrix onto a solid sorbent (Abselut Nexus). This technique is useful for screening biological tissues that contain lipids for musk compounds. Analytes are desorbed from the sorbent trap sequentially with polar and nonpolar solvents, concentrated, and directly analyzed by high resolution gas chromatography coupled to a mass spectrometer operating in the selected ion monitoring mode. In this paper, we analyzed two homogenized samples of whole fish tissues with spiked synthetic musk compounds using closed-loop stripping analysis (CLSA) and pressurized liquid extraction (PLE). The analytes were not recovered quantitatively but the extraction yield was sufficiently reproducible for at least semi-quantitative purposes (screening). The method was less expensive to implement and required significantly less sample preparation than the PLE technique. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water,

Caracteres estruturais foliares de espécies de Arachis e sua relação com a cercosporiose

Directory of Open Access Journals (Sweden)

Pablo Rodrigues Sanine

2012-07-01

Full Text Available A cercosporiose, causada pelo fungo Cercosporidium personatum, é uma doença de grande importância para a cultura do amendoim (Arachis hypogaea. O objetivo deste trabalho foi quantificar caracteres estruturais do limbo foliar, em dois cultivares e quatro acessos de três espécies de Arachis, procurando relacioná-los com graus de resistência à cercosporiose. Foram amostradas porções do terço médio da região internvervural, do terceiro ou quarto folíolo da segunda folha contada a partir do ápice caulinar, sendo as amostras infiltradas em historresina, seccionadas com 7 µm de espessura e coradas com azul de toluidina. Os caracteres quantificados foram: área da secção da região internervural; área, espessura, e porcentagem da epiderme das faces adaxial e abaxial, da hipoderme, e do parênquima; área e espessura do mesofilo; área do complexo estomático; espessura da folha; número de tricomas, estômatos, cristais de oxalato de cálcio e idioblastos de mucilagem; e comprimento dos ostíolos. Os dados foram submetidos aos testes estatísticos multivariados de Análise de Agrupamento e Análise de Componentes Principais. Os caracteres referentes à epiderme da face abaxial, hipoderme, parênquima, , tricomas, estômatos e idioblastos de mucilagem permitiram diferenciar A. hypogaea, A. magnae A. stenosperma. O cultivar IAC-Tatu de A. hypogaeae o acesso 9017 de A. stenospermacaracterizaram-se como suscetíveis à cercosporiose, enquanto o cultivar 850 de A. hypogaea, os acessos 30097 e 13748 de A. magna, e o acesso 10229 de A. stenospermaforam considerados resistentes.

Energy-Efficient Bioalcohol Recovery by Gel Stripping

Science.gov (United States)

Godbole, Rutvik; Ma, Lan; Hedden, Ronald

2014-03-01

Design of energy-efficient processes for recovering butanol and ethanol from dilute fermentations is a key challenge facing the biofuels industry due to the high energy consumption of traditional multi-stage distillation processes. Gel stripping is an alternative purification process by which a dilute alcohol is stripped from the fermentation product by passing it through a packed bed containing particles of a selectively absorbent polymeric gel material. The gel must be selective for the alcohol, while swelling to a reasonable degree in dilute alcohol-water mixtures. To accelerate materials optimization, a combinatorial approach is taken to screen a matrix of copolymer gels having orthogonal gradients in crosslinker concentration and hydrophilicity. Using a combination of swelling in pure solvents, the selectivity and distribution coefficients of alcohols in the gels can be predicted based upon multi-component extensions of Flory-Rehner theory. Predictions can be validated by measuring swelling in water/alcohol mixtures and conducting h HPLC analysis of the external liquid. 95% + removal of butanol from dilute aqueous solutions has been demonstrated, and a mathematical model of the unsteady-state gel stripping process has been developed. NSF CMMI Award 1335082.

Culture technique of rabbit primary epidermal keratinocytes

Directory of Open Access Journals (Sweden)

Marini M

2012-10-01

Full Text Available The epidermis is the protective covering outer layer of the mammalian skin. The epidermal cells are stratified squamous epithelia which undergo continuous differentiation of loss and replacement of cells. Ninety per cent of epidermal cells consist of keratinocytes that are found in the basal layer of the stratified epithelium called epidermis. Keratinocytes are responsible for forming tight junctions with the nerves of the skin as well as in the process of wound healing. This article highlights the method of isolation and culture of rabbit primary epidermal keratinocytes in vitro. Approximately 2cm x 2cm oval shaped line was drawn on the dorsum of the rabbit to mark the surgical area. Then, the skin was carefully excised using a surgical blade and the target skin specimens harvested from the rabbits were placed in transport medium comprising of Dulbecco’s Modified Eagle Medium (DMEM and 1% of antibiotic-antimycotic solution. The specimens were transferred into a petri dish containing 70% ethanol and washed for 5 min followed by a wash in 1 x Dulbecco’s Phosphate Buffered Saline (DBPS. Then, the skin specimens were placed in DMEM and minced into small pieces using a scalpel. The minced pieces were placed in a centrifuge tube containing 0.6% Dispase and 1% antibiotic-antimycotic solution overnight at 4°C in a horizontal orientation. The epidermis layer (whitish, semi-transparent was separated from the dermis (pink, opaque, gooey with the aid of curved forceps by fixing the dermis with one pair of forceps while detaching the epidermis with the second pair. The cells were cultured at a density of 4 x 104 cells/cm2 in culture flask at 37°C and 5% CO2. The cell morphology of the keratinocytes was analyzed using inverted microscope.

Enrichment of unlabeled human Langerhans cells from epidermal cell suspensions by discontinuous density gradient centrifugation

NARCIS (Netherlands)

Teunissen, M. B.; Wormmeester, J.; Kapsenberg, M. L.; Bos, J. D.

1988-01-01

In this report we introduce an alternative procedure for enrichment of human epidermal Langerhans cells (LC) from epidermal cell suspensions of normal skin. By means of discontinuous Ficoll-Metrizoate density gradient centrifugation, a fraction containing high numbers of viable, more than 80% pure

Electron capture by highly stripped ions

International Nuclear Information System (INIS)

Greenland, P.T.

1981-06-01

This review describes theories of electron capture suitable for the description of rearrangement collisions between atomic hydrogen and completely stripped projectiles with charge greater than unity. The region of impact velocity considered lies between 0.05 and 3 au, which is of technological importance in fusion power devices. The semiclassical, impact parameter formalism is discussed and the use of atomic expansions at medium impact velocity is described. Experimental results for both completely and partially stripped projectiles are reviewed. The use of a molecular basis at low energy, and the role of pseudocrossings peculiar to the two centre Coulomb interaction are described. Finally, purely classical techniques, in which the electron wavefunction is represented by an ensemble of Kepler orbits are considered. The review was completed in February 1981. (author)

Nuclear reactor spring strip grid spacer

International Nuclear Information System (INIS)

Patterson, J.F.; Flora, B.S.

1980-01-01

An improved and novel grid spacer was developed for use in nuclear reactor fuel assemblies. It is comprised of a series of intersecting support strips and a peripheral support band attached to the ends of the support strips. Each of the openings into which the fuel element is inserted has a number of protruding dimples and springs extending in different directions. The dimples coact with the springs to secure the fuel rods in the openings. Compared with previous designs, this design gives more positive alignment of the support stips while allowing greater flexibility to counterbalance the effects of thermal expansion. The springs are arranged in alternating directions so that the reaction forces tend to counterbalance each other, which in turn minimizes the reaction loads on the supporting structure. (D.N.)

ALICE Silicon Strip Detector

CERN Multimedia

Nooren, G

2013-01-01

The Silicon Strip Detector (SSD) constitutes the two outermost layers of the Inner Tracking System (ITS) of the ALICE Experiment. The SSD plays a crucial role in the tracking of the particles produced in the collisions connecting the tracks from the external detectors (Time Projection Chamber) to the ITS. The SSD also contributes to the particle identification through the measurement of their energy loss.

Distribution of electric field and charge collection in silicon strip detectors

International Nuclear Information System (INIS)

Anokhin, I.E.; Zinets, O.S.

1995-01-01

The distribution of electric field in silicon strip detectors is analyzed in the case of dull depletion as well as for partial depletion. Influence of inhomogeneous electric fields on the charge collection and performances of silicon strip detectors is discussed

Optimal allocation of leaf epidermal area for gas exchange.

Science.gov (United States)

de Boer, Hugo J; Price, Charles A; Wagner-Cremer, Friederike; Dekker, Stefan C; Franks, Peter J; Veneklaas, Erik J

2016-06-01

A long-standing research focus in phytology has been to understand how plants allocate leaf epidermal space to stomata in order to achieve an economic balance between the plant's carbon needs and water use. Here, we present a quantitative theoretical framework to predict allometric relationships between morphological stomatal traits in relation to leaf gas exchange and the required allocation of epidermal area to stomata. Our theoretical framework was derived from first principles of diffusion and geometry based on the hypothesis that selection for higher anatomical maximum stomatal conductance (gsmax ) involves a trade-off to minimize the fraction of the epidermis that is allocated to stomata. Predicted allometric relationships between stomatal traits were tested with a comprehensive compilation of published and unpublished data on 1057 species from all major clades. In support of our theoretical framework, stomatal traits of this phylogenetically diverse sample reflect spatially optimal allometry that minimizes investment in the allocation of epidermal area when plants evolve towards higher gsmax . Our results specifically highlight that the stomatal morphology of angiosperms evolved along spatially optimal allometric relationships. We propose that the resulting wide range of viable stomatal trait combinations equips angiosperms with developmental and evolutionary flexibility in leaf gas exchange unrivalled by gymnosperms and pteridophytes. © 2016 The Authors New Phytologist © 2016 New Phytologist Trust.

Experimental evidence that wildflower strips increase pollinator visits to crops.

Science.gov (United States)

Feltham, Hannah; Park, Kirsty; Minderman, Jeroen; Goulson, Dave

2015-08-01

Wild bees provide a free and potentially diverse ecosystem service to farmers growing pollination-dependent crops. While many crops benefit from insect pollination, soft fruit crops, including strawberries are highly dependent on this ecosystem service to produce viable fruit. However, as a result of intensive farming practices and declining pollinator populations, farmers are increasingly turning to commercially reared bees to ensure that crops are adequately pollinated throughout the season. Wildflower strips are a commonly used measure aimed at the conservation of wild pollinators. It has been suggested that commercial crops may also benefit from the presence of noncrop flowers; however, the efficacy and economic benefits of sowing flower strips for crops remain relatively unstudied. In a study system that utilizes both wild and commercial pollinators, we test whether wildflower strips increase the number of visits to adjacent commercial strawberry crops by pollinating insects. We quantified this by experimentally sowing wildflower strips approximately 20 meters away from the crop and recording the number of pollinator visits to crops with, and without, flower strips. Between June and August 2013, we walked 292 crop transects at six farms in Scotland, recording a total of 2826 pollinators. On average, the frequency of pollinator visits was 25% higher for crops with adjacent flower strips compared to those without, with a combination of wild and commercial bumblebees (Bombus spp.) accounting for 67% of all pollinators observed. This effect was independent of other confounding effects, such as the number of flowers on the crop, date, and temperature. Synthesis and applications. This study provides evidence that soft fruit farmers can increase the number of pollinators that visit their crops by sowing inexpensive flower seed mixes nearby. By investing in this management option, farmers have the potential to increase and sustain pollinator populations over time.

Advancements of floating strip Micromegas detectors for medical imaging applications

Energy Technology Data Exchange (ETDEWEB)

Klitzner, Felix; Biebel, Otmar; Bortfeldt, Jonathan; Flierl, Bernhard [LS Schaile, LMU Muenchen (Germany); Magallanes, Lorena [LS Parodi, LMU Muenchen (Germany); Universitaetsklinikum Heidelberg (Germany); Parodi, Katia [LS Parodi, LMU Muenchen (Germany); Heidelberger Ionenstrahl Therapiezentrum (Germany); Voss, Bernd [Gesellschaft fuer Schwerionenforschung, Darmstadt (Germany)

2016-07-01

Floating strip Micromegas have proven to be high-rate capable tracking detectors with excellent spatial and temporal resolution for particle fluxes up to 7 MHz/cm{sup 2}. To further increase the high-rate capability a Ne:CF{sub 4} 86:14 vol.% gas mixture has been used as detector gas. We present results from measurements with a seven detector system consisting of six low material budget floating strip Micromegas, a GEM detector and a scintillator based particle range telescope. The gaseous and the scintillation detectors were read out with APV25 frontend boards, allowing for single strip readout with pulse height and timing information. A two-dimensional readout anode for floating strip Micromegas has been tested for the first time. The Micromegas detectors were operated with minimal additional drift field, which significantly improves the timing resolution and also the spatial resolution for inclined tracks. We discuss the detector performance in high-rate carbon and proton beams at the Heidelberg Ion Beam Therapy Center (HIT) and present radiographies of phantoms, acquired with the system.

MUST: A silicon strip detector array for radioactive beam experiments

CERN Document Server

Blumenfeld, Y; Sauvestre, J E; Maréchal, F; Ottini, S; Alamanos, N; Barbier, A; Beaumel, D; Bonnereau, B; Charlet, D; Clavelin, J F; Courtat, P; Delbourgo-Salvador, P; Douet, R; Engrand, M; Ethvignot, T; Gillibert, A; Khan, E; Lapoux, V; Lagoyannis, A; Lavergne, L; Lebon, S; Lelong, P; Lesage, A; Le Ven, V; Lhenry, I; Martin, J M; Musumarra, A; Pita, S; Petizon, L; Pollacco, E; Pouthas, J; Richard, A; Rougier, D; Santonocito, D; Scarpaci, J A; Sida, J L; Soulet, C; Stutzmann, J S; Suomijärvi, T; Szmigiel, M; Volkov, P; Voltolini, G

1999-01-01

A new and innovative array, MUST, based on silicon strip technology and dedicated to the study of reactions induced by radioactive beams on light particles is described. The detector consists of 8 silicon strip - Si(Li) telescopes used to identify recoiling light charged particles through time of flight, energy loss and energy measurements and to determine precisely their scattering angle through X, Y position measurements. Each 60x60 mm sup 2 double sided silicon strip detector with 60 vertical and 60 horizontal strips yields an X-Y position resolution of 1 mm, an energy resolution of 50 keV, a time resolution of around 1 ns and a 500 keV energy threshold for protons. The backing Si(Li) detectors stop protons up to 25 MeV with a resolution of approximately 50 keV. CsI crystals read out by photo-diodes which stop protons up to 70 MeV are added to the telescopes for applications where higher energy particles need to be detected. The dedicated electronics in VXIbus standard allow us to house the 968 logic and a...

Morfoanatomia dos órgãos vegetativos de Piper hispidum Sw. (Piperaceae

Directory of Open Access Journals (Sweden)

Adriana L.M. Albiero

Full Text Available O presente trabalho teve por objetivo o estudo morfoanatômico dos órgãos vegetativos de Piper hispidum, visando a estabelecer características marcantes para a sua identificação e auxiliar estudos taxonômicos e farmacobotânicos. O material vegetal fresco e fixado foi estudado segundo as técnicas usuais de corte e coloração, incluindo análise em MEV. Piper hispidum é um arbusto com caule cilíndrico, nodoso, verde claro, com folhas alternas, ovadas, de cor verde-escura na face adaxial e verde claro na abaxial. Dentre as características anatômicas importantes para sua identificação destacam-se: parênquima cortical da raiz apresentando grupos de esclereídes. Córtex caulinar com faixas descontínuas de colênquima do tipo angular e tecido vascular organizado em dois círculos descontínuos de feixes colaterais. A folha é dorsiventral, hipoestomática, com estômatos tetracíticos. Hipoderme adaxial descontínua e abaxial frouxa com número variável de camadas; tricomas tectores e glandulares ocorrem nas duas faces. Epiderme uniestratificada e idioblastos oleíferos ocorrem em todos os órgãos.

Evaluation of FOXFET biased ac-coupled silicon strip detector prototypes for CDF SVX upgrade

Energy Technology Data Exchange (ETDEWEB)

Laakso, M. (Fermi National Accelerator Lab., Batavia, IL (United States) Research Inst. for High Energy Physics (SEFT), Helsinki (Finland))

1992-03-01

Silicon microstrip detectors for high-precision charged particle position measurements have been used in nuclear and particle physics for years. The detectors have evolved from simple surface barrier strip detectors with metal strips to highly complicated double-sided AC-coupled junction detectors. The feature of AC-coupling the readout electrodes from the diode strips necessitates the manufacture of a separate biasing structure for the strips, which comprises a common bias line together with a means for preventing the signal from one strip from spreading to its neighbors through the bias line. The obvious solution to this is to bias the strips through individual high value resistors. These resistors can be integrated on the detector wafer by depositing a layer of resistive polycrystalline silicon and patterning it to form the individual resistors. To circumvent the extra processing step required for polysilicon resistor processing and the rather difficult tuning of the process to obtain uniform and high enough resistance values throughout the large detector area, alternative methods for strip biasing have been devised. These include the usage of electron accumulation layer resistance for N{sup +}{minus} strips or the usage of the phenomenon known as the punch-through effect for P{sup +}{minus} strips. In this paper we present measurement results about the operation and radiation resistance of detectors with a punch-through effect based biasing structure known as a Field OXide Field-Effect Transistor (FOXFET), and present a model describing the FOXFET behavior. The studied detectors were prototypes for detectors to be used in the CDF silicon vertex detector upgrade.

Evaluation of FOXFET biased ac-coupled silicon strip detector prototypes for CDF SVX upgrade

International Nuclear Information System (INIS)

Laakso, M.

1992-03-01

Silicon microstrip detectors for high-precision charged particle position measurements have been used in nuclear and particle physics for years. The detectors have evolved from simple surface barrier strip detectors with metal strips to highly complicated double-sided AC-coupled junction detectors. The feature of AC-coupling the readout electrodes from the diode strips necessitates the manufacture of a separate biasing structure for the strips, which comprises a common bias line together with a means for preventing the signal from one strip from spreading to its neighbors through the bias line. The obvious solution to this is to bias the strips through individual high value resistors. These resistors can be integrated on the detector wafer by depositing a layer of resistive polycrystalline silicon and patterning it to form the individual resistors. To circumvent the extra processing step required for polysilicon resistor processing and the rather difficult tuning of the process to obtain uniform and high enough resistance values throughout the large detector area, alternative methods for strip biasing have been devised. These include the usage of electron accumulation layer resistance for N + - strips or the usage of the phenomenon known as the punch-through effect for P + - strips. In this paper we present measurement results about the operation and radiation resistance of detectors with a punch-through effect based biasing structure known as a Field OXide Field-Effect Transistor (FOXFET), and present a model describing the FOXFET behavior. The studied detectors were prototypes for detectors to be used in the CDF silicon vertex detector upgrade

Study of the technics of coating stripping and FBG writing on polyimide fiber

Science.gov (United States)

Song, ZhiQiang; Qi, HaiFeng; Ni, JiaSheng; Wang, Chang

2017-10-01

Compared with ordinary optical fiber, polyimide fiber has the characteristics of high temperature resistance and high strength, which has important application in the field of optical fiber sensing. The common methods of polyimide coating stripping were introduced in this paper, including high temperature stripping, chemical stripping and arc ablation. In order to meet the requirements of FBG writing technology, a method using argon ion laser ablation coating was proposed. The method can precisely control the stripping length of the coating and completely does not affect the tensile strength of the optical fiber. According to the experiment, the fabrication process of polyimide FBG is stripping-hydrogen loadingwriting. Under the same conditions, 10 FBG samples were fabricated with good uniformity of wavelength bandwidth and reflectivity. UV laser ablation of polyimide coating has been proved to be a safe, reliable and efficient method.

HST IMAGING OF DUST STRUCTURES AND STARS IN THE RAM PRESSURE STRIPPED VIRGO SPIRALS NGC 4402 AND NGC 4522: STRIPPED FROM THE OUTSIDE IN WITH DENSE CLOUD DECOUPLING

International Nuclear Information System (INIS)

Abramson, A.; Kenney, J.; Crowl, H.; Tal, T.

2016-01-01

We describe and constrain the origins of interstellar medium (ISM) structures likely created by ongoing intracluster medium (ICM) ram pressure stripping in two Virgo Cluster spirals, NGC 4522 and NGC 4402, using Hubble Space Telescope (HST) BVI images of dust extinction and stars, as well as supplementary H i, H α , and radio continuum images. With a spatial resolution of ∼10 pc in the HST images, this is the highest-resolution study to date of the physical processes that occur during an ICM–ISM ram pressure stripping interaction, ram pressure stripping's effects on the multi-phase, multi-density ISM, and the formation and evolution of ram-pressure-stripped tails. In dust extinction, we view the leading side of NGC 4402 and the trailing side of NGC 4522, and so we see distinct types of features in both. In both galaxies, we identify some regions where dense clouds are decoupling or have decoupled and others where it appears that kiloparsec-sized sections of the ISM are moving coherently. NGC 4522 has experienced stronger, more recent pressure and has the “jellyfish” morphology characteristic of some ram-pressure-stripped galaxies. Its stripped tail extends up from the disk plane in continuous upturns of dust and stars curving up to ∼2 kpc above the disk plane. On the other side of the galaxy, there is a kinematically and morphologically distinct extraplanar arm of young, blue stars and ISM above a mostly stripped portion of the disk, and between it and the disk plane are decoupled dust clouds that have not been completely stripped. The leading side of NGC 4402 contains two kiloparsec-scale linear dust filaments with complex substructure that have partially decoupled from the surrounding ISM. NGC 4402 also contains long dust ridges, suggesting that large parts of the ISM are being pushed out at once. Both galaxies contain long ridges of polarized radio continuum emission indicating the presence of large-scale, ordered magnetic fields. We propose that

Inflammatory linear verrucous epidermal naevus: Report of three ...

African Journals Online (AJOL)

Background: Epidermal naevi are congenital harmatomas that arise from embryonal ectodermal cells. The inflammatory linear verrucous variant is rare and presents with disturbing symptoms. In blacks the classical erythema is not common but pruritus and discharge are the commonest features. Methods and results: We ...

The bacterial contamination rate of glucose meter test strips in the hospital setting

Science.gov (United States)

Al-Rubeaan, Khalid A.; Saeb, Amr T. M.; AlNaqeb, Dhekra M.; AlQumaidi, Hamed M.; AlMogbel, Turki A.

2016-01-01

Objectives: To assess the rate of bacterial contamination of the multi-use vial and single-use packed glucose meter strips, and to identify the type and frequency of various bacterial contamination in different hospital wards. Methods: This prospective observational study was conducted by a team from the Strategic Center for Diabetes Research in 7 general hospitals in the Central region of Saudi Arabia during the period from August to September 2014 to assess the bacterial contamination rate of the unused strips. A total of 10,447 strips were cultured using proper agar media and incubated both aerobically and anaerobically. Results: The total bacterial contamination rate for the multi-use vials glucose strips was 31.7%, while single-use packed strips were not contaminated at all. Ministry of Health hospitals had the highest contamination rates compared with other hospitals. Critical, obstetric, and surgical wards had the highest bacterial isolates number, where most were in the risk group 3 according to the National Institute of Health guidelines. Staphylococcus species were the most common bacteria found. Conclusion: Glucose meter strips should be recognized as a source of bacterial contamination that could be behind serious hospital acquired infections. The hospital infection control team should adopt proper measures to implement protocols for glucose meter cleaning and glucose strips handling. PMID:27570855

Choosing order of operations to accelerate strip structure analysis in parameter range

Science.gov (United States)

Kuksenko, S. P.; Akhunov, R. R.; Gazizov, T. R.

2018-05-01

The paper considers the issue of using iteration methods in solving the sequence of linear algebraic systems obtained in quasistatic analysis of strip structures with the method of moments. Using the analysis of 4 strip structures, the authors have proved that additional acceleration (up to 2.21 times) of the iterative process can be obtained during the process of solving linear systems repeatedly by means of choosing a proper order of operations and a preconditioner. The obtained results can be used to accelerate the process of computer-aided design of various strip structures. The choice of the order of operations to accelerate the process is quite simple, universal and could be used not only for strip structure analysis but also for a wide range of computational problems.

Etanercept therapy for toxic epidermal necrolysis.

Science.gov (United States)

Paradisi, Andrea; Abeni, Damiano; Bergamo, Fabio; Ricci, Francesco; Didona, Dario; Didona, Biagio

2014-08-01

Toxic epidermal necrolysis (TEN) is a severe and potentially lethal drug reaction for which no standard treatment is available. To describe a case series of patients with TEN treated with a single dose of etanercept. We observed 10 consecutive patients with TEN. For each patient, we recorded the presence of comorbidities and all the drugs recently started (ie, in the last month). In all cases, 50 mg of etanercept was administered in a single subcutaneous injection. The clinical severity of disease was computed using the SCORe of Toxic Epidermal Necrosis (SCORTEN) scale. Using the probabilities of death linked to each level of SCORTEN score, we calculated the expected probability of death in our patients. Healing was defined as complete reepithelialization, and a time to healing curve was then obtained using the Kaplan-Meier method. All patients promptly responded to treatment, reaching complete reepithelialization without complications or side effects. The median time to healing was 8.5 days. This is a small, uncontrolled case series. These preliminary results suggest the possibility that tumor necrosis factor-alfa may be an effective target for control of TEN, a dangerous skin condition for which no effective cure has yet been found. Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Steroid hormone and epidermal growth factor receptors in meningiomas.

Science.gov (United States)

Horsfall, D J; Goldsmith, K G; Ricciardelli, C; Skinner, J M; Tilley, W D; Marshall, V R

1989-11-01

A prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.

Strip-Bark Morphology and Radial Growth Trends in Ancient Pinus sibirica Trees From Central Mongolia

Science.gov (United States)

Leland, Caroline; Cook, Edward R.; Andreu-Hayles, Laia; Pederson, Neil; Hessl, Amy; Anchukaitis, Kevin J.; Byambasuren, Oyunsanaa; Nachin, Baatarbileg; Davi, Nicole; D'Arrigo, Rosanne; Griffin, Kevin; Bishop, Daniel A.; Rao, Mukund Palat

2018-03-01

Some of the oldest and most important trees used for dendroclimatic reconstructions develop strip-bark morphology, in which only a portion of the stem contains living tissue. Yet the ecophysiological factors initiating strip bark and the potential effect of cambial dieback on annual ring widths and tree-ring estimates of past climate remain poorly understood. Using a combination of field observations and tree-ring data, we investigate the causes and timing of cambial dieback events in Pinus sibirica strip-bark trees from central Mongolia and compare the radial growth rates and trends of strip-bark and whole-bark trees over the past 515 years. Results indicate that strip bark is more common on the southern aspect of trees, and dieback events were most prevalent in the 19th century, a cold and dry period. Further, strip-bark and whole-bark trees have differing centennial trends, with strip-bark trees exhibiting notably large increases in ring widths at the beginning of the 20th century. We find a steeper positive trend in the strip-bark chronology relative to the whole-bark chronology when standardizing with age-dependent splines. We hypothesize that localized warming on the southern side of stems due to solar irradiance results in physiological damage and dieback and leads to increasing tree-ring increment along the living portion of strip-bark trees. Because the impact of cambial dieback on ring widths likely varies depending on species and site, we suggest conducting a comparison of strip-bark and whole-bark ring widths before statistically treating ring-width data for climate reconstructions.

Analysis of Lead and Zinc by Mercury-Free Potentiometric Stripping Analysis

DEFF Research Database (Denmark)

Andersen, Jens Enevold Thaulov

1997-01-01

A method is presented for trace-element analysis of lead and zinc by potentiometric stripping analysis (PSA) where both the glassy-carbon working electrode and the electrolyte are free of mercury. Analysis of zinc requires an activation procedure of the glassy-carbon electrode. The activation...... is performed by pre-concentrating zinc on glassy carbon at -1400 mV(SCE) in a mercury-free electrolyte containing 0.1 M HCl and 2 ppm Zn2+, followed by stripping at approx. -1050 mV. A linear relationship between stripping peak areas, recorded in the derivative mode, and concentration was found...

Assessment of the Developmental Toxicity of Epidermal Growth ...

African Journals Online (AJOL)

Purpose: To determine whether epidermal growth factor (EGF) is involved in reproductive developmental toxicity, using the embryonic stem cell test (EST), as well as ascertain how EGF influences embryonic development. Methods: To predict developmental toxicity on the basis of reducing cell viability and inhibition of ...

Continuous liquid sheet generator for ion stripping

International Nuclear Information System (INIS)

Gavin, B.; Batson, P.; Leemann, B.; Rude, B.

1984-10-01

Many of the technical problems of generating a large thin liquid sheet from 0.02 to 0.20 μm thick (3 to 40 μgm/cm 2 ) have been solved. It is shown that this perennial sheet is stable and consonant in dimension. Several ion beam species from the SuperHILAC have been used for evaluation; at 0.11 MeV/n. In one of three modes this sheet serves as an equivalent substitute for a carbon foil. The second mode is characterized by a solid-like charge state distribution but with a varying fraction of unstripped ions. The third mode gives stripping performance akin to a vapor stripping medium. 9 references, 7 figures

Cascade air stripping: Techno-economic evaluation of a new ground water treatment process

International Nuclear Information System (INIS)

Nirmalakhandan, N.; Peace, G.L.; Shanbhag, A.R.; Speece, R.E.

1992-01-01

A simple modification of the conventional air-stripping process introduced as cascade air stripping is proposed for efficient and economical removal of semivolatile and low volatility contaminants from ground water. The technical feasibility and economic viability of this process are evaluated using field test results and cost model simulations. The field tests enabled the process model to be verified at various water flow rates ranging from 150 gpm to 400 gpm. The field study also demonstrated the feasibility of the proposed system at a near full-scale level. Cost models were used to compare the proposed process to conventional air stripping and granular-activated carbon adsorption in removing a range of contaminants. This analysis showed that the treatment cost (cents/1,000 gal) of cascade air stripping is about 15% lower than conventional air stripping and about 40% lower than granular-activated carbon adsorption

Psoriatic T cells reduce epidermal turnover time and affect cell proliferation contributed from differential gene expression.

Science.gov (United States)

Li, Junqin; Li, Xinhua; Hou, Ruixia; Liu, Ruifeng; Zhao, Xincheng; Dong, Feng; Wang, Chunfang; Yin, Guohua; Zhang, Kaiming

2015-09-01

Psoriasis is mediated primarily by T cells, which reduce epidermal turnover time and affect keratinocyte proliferation. We aimed to identify differentially expressed genes (DEG) in T cells from normal, five pairs of monozygotic twins concordant or discordant for psoriasis, to determine whether these DEG may account for the influence to epidermal turnover time and keratinocyte proliferation. The impact of T cells on keratinocyte proliferation and epidermal turnover time were investigated separately by immunohistochemistry and cultured with (3) H-TdR. mRNA expression patterns were investigated by RNA sequencing and verified by real-time reverse transcription polymerase chain reaction. After co-culture with psoriatic T cells, the expression of Ki-67, c-Myc and p53 increased, while expression of Bcl-2 and epidermal turnover time decreased. There were 14 DEG which were found to participate in the regulation of cell proliferation or differentiation. Psoriatic T cells exhibited the ability to decrease epidermal turnover time and affect keratinocyte proliferation because of the differential expression of PPIL1, HSPH1, SENP3, NUP54, FABP5, PLEKHG3, SLC9A9 and CHCHD4. © 2015 Japanese Dermatological Association.

Air Stripping Designs and Reactive Water Purification Processes for the Lunar Surface

Science.gov (United States)

Boul, Peter J.; Lange, Kevin; Conger, Bruce; Anderson, Molly

2010-01-01

Air stripping designs are considered to reduce the presence of volatile organic compounds in the purified water. Components of the wastewater streams are ranked by Henry's Law Constant and the suitability of air stripping in the purification of wastewater in terms of component removal is evaluated. Distillation processes are modeled in tandem with air stripping to demonstrate the potential effectiveness and utility of these methods in recycling wastewater on the Moon. Scaling factors for distillation and air stripping columns are presented to account for the difference in the lunar gravitation environment. Commercially available distillation and air stripping units which are considered suitable for Exploration Life Support are presented. The advantages to the various designs are summarized with respect to water purity levels, power consumption, and processing rates. An evaluation of reactive distillation and air stripping is presented with regards to the reduction of volatile organic compounds in the contaminated water and air. Among the methods presented, an architecture is presented for the evaluation of the simultaneous oxidation of organics in air and water. These and other designs are presented in light of potential improvements in power consumptions and air and water purities for architectures which include catalytic activity integrated into the water processor. In particular, catalytic oxidation of organics may be useful as a tool to remove contaminants that more traditional distillation and/or air stripping columns may not remove. A review of the current leading edge at the commercial level and at the research frontier in catalytically active materials is presented. Themes and directions from the engineering developments in catalyst design are presented conceptually in light of developments in the nanoscale chemistry of a variety of catalyst materials.

Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response.

Science.gov (United States)

Elentner, Andreas; Schmuth, Matthias; Yannoutsos, Nikolaos; Eichmann, Thomas O; Gruber, Robert; Radner, Franz P W; Hermann, Martin; Del Frari, Barbara; Dubrac, Sandrine

2018-01-01

The skin is in daily contact with environmental pollutants, but the long-term effects of such exposure remain underinvestigated. Many of these toxins bind and activate the pregnane X receptor (PXR), a ligand-activated transcription factor that regulates genes central to xenobiotic metabolism. The objective of this work was to investigate the effect of constitutive activation of PXR in the basal layer of the skin to mimic repeated skin exposure to noxious molecules. We designed a transgenic mouse model that overexpresses the human PXR gene linked to the herpes simplex VP16 domain under the control of the keratin 14 promoter. We show that transgenic mice display increased transepidermal water loss and elevated skin pH, abnormal stratum corneum lipids, focal epidermal hyperplasia, activated keratinocytes expressing more thymic stromal lymphopoietin, a T helper type 2/T helper type 17 skin immune response, and increased serum IgE. Furthermore, the cutaneous barrier dysfunction precedes development of the T helper type 2/T helper type 17 inflammation in transgenic mice, thereby mirroring the time course of atopic dermatitis development in humans. Moreover, further experiments suggest increased PXR signaling in the skin of patients with atopic dermatitis when compared with healthy skin. Thus, PXR activation by environmental pollutants may compromise epidermal barrier function and favor an immune response resembling atopic dermatitis. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The epidermal biosynthesis of cholecalciferol (vitamin D3)

International Nuclear Information System (INIS)

Beadle, P.C.

1977-01-01

An attempt has been made to calculate the rate of ultraviolet absorption by 7-dehydrocholesterol, provitamin D 3 , in the epidermis as a function of latitude, season and skin type, in the hope that it will provide an upper-limit estimate of the epidermal vitamin production. The results indicate that a significant fraction of the total epidermal production may occur in the stratum corneum with figures of 15 and 31% being found for non-pigmented and pigmented epidermises, respectively. Total production in negroid epidermis is predicted to be about 40% of that in the caucasian one and the latitudinal variation is greater than the seasonal variation, in agreement with the behaviour of the available solar ultraviolet. Overall production rates were sufficiently high for it to be unnecessary to invoke an enhanced absorption mechanism for the provitamin, although the results do indicate that there may be a risk of deficient production above about 40 0 N. (author)

ATLAS ITk Strip Detector for High-Luminosity LHC

CERN Document Server

Kroll, Jiri; The ATLAS collaboration

2017-01-01

The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High-Luminosity LHC that is scheduled for 2026. The expected peak instantaneous luminosity up to 7.5E34 per second and cm2 corresponding to approximately 200 inelastic proton-proton interactions per beam crossing, radiation damage at an integrated luminosity of 3000/fb and hadron fluencies over 1E16 1 MeV neutron equivalent per cm2, as well as fast hardware tracking capability that will bring Level-0 trigger rate of a few MHz down to a Level-1 trigger rate below 1 MHz require a replacement of existing Inner Detector by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The current prototyping phase, that is working with ITk Strip Detector consisting of a four-layer barrel and a forward region composed of six discs on each side of the barrel, has resulted in the ATLAS ITk Strip Detector Technical Design Report (TDR), which starts the pre-production readiness phase at the ...

The ATLAS tracker strip detector for HL-LHC

CERN Document Server

Cormier, Kyle James Read; The ATLAS collaboration

2016-01-01

As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

The ATLAS tracker strip detector for HL-LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00512833; The ATLAS collaboration

2017-01-01

As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

Fabrication of double-sided thallium bromide strip detectors

Energy Technology Data Exchange (ETDEWEB)

Hitomi, Keitaro, E-mail: keitaro.hitomi@qse.tohoku.ac.jp [Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579 (Japan); Nagano, Nobumichi [Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579 (Japan); Onodera, Toshiyuki [Department of Electronics and Intelligent Systems, Tohoku Institute of Technology, Sendai 982-8577 (Japan); Kim, Seong-Yun; Ito, Tatsuya; Ishii, Keizo [Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579 (Japan)

2016-07-01

Double-sided strip detectors were fabricated from thallium bromide (TlBr) crystals grown by the traveling-molten zone method using zone-purified materials. The detectors had three 3.4-mm-long strips with 1-mm widths and a surrounding electrode placed orthogonally on opposite surfaces of the crystals at approximately 6.5×6.5 mm{sup 2} in area and 5 mm in thickness. Excellent charge transport properties for both electrons and holes were observed from the TlBr crystals. The mobility-lifetime products for electrons and holes in the detector were measured to be ~3×10{sup −3} cm{sup 2}/V and ~1×10{sup −3} cm{sup 2}/V, respectively. The {sup 137}Cs spectra corresponding to the gamma-ray interaction position were obtained from the detector. An energy resolution of 3.4% of full width at half maximum for 662-keV gamma rays was obtained from one “pixel” (an intersection of the strips) of the detector at room temperature.

ATLAS ITk Strip Detector for High-Luminosity LHC

CERN Document Server

Kroll, Jiri; The ATLAS collaboration

2017-01-01

The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High-Luminosity LHC that is scheduled for 2026. The expected peak instantaneous luminosity up to $7.5\\times10^{34}\\;\\mathrm{cm}^{-2}\\mathrm{s}^{-1}$ corresponding to approximately 200 inelastic proton-proton interactions per beam crossing, radiation damage at an integrated luminosity of $3000\\;\\mathrm{fb}^{-1}$ and hadron fluencies over $2\\times10^{16}\\;\\mathrm{n}_{\\mathrm{eq}}/\\mathrm{cm}^{2}$, as well as fast hardware tracking capability that will bring Level-0 trigger rate of a few MHz down to a Level-1 trigger rate below 1 MHz require a replacement of existing Inner Detector by an all-silicon Inner Tracker with a pixel detector surrounded by a strip detector. The current prototyping phase, that is working with ITk Strip Detector consisting of a four-layer barrel and a forward region composed of six disks on each side of the barrel, has resulted in the ATLAS Inner Tracker Strip Detector Technical Design R...

Simulation of accelerated strip cooling on the hot rolling mill run-out roller table

International Nuclear Information System (INIS)

Muhin, U.; Belskij, S.; Makarov, E.; Koinov, T.

2013-01-01

Full text: A mathematical model of the thermal state of the metal on the run-out roller table of a continuous wide hot-strip mill is presented. The mathematical model takes into account the heat generation during the polymorphic γ → α transformation of super cooled austenite phase and the influence of chemical composition on the physical properties of the steel. The model allows the calculation of modes of accelerated cooling of strips on the run-out roller table of a continuous wide hot strip mill. Winding temperature calculation error does not exceed 20 °C for 98.5 % of the strips from low-carbon and low-alloyed steels. key words: hot rolled, wide-strip, accelerated cooling, run-out roller table, polymorphic transformation, mathematical modeling

Genetics Home Reference: Stevens-Johnson syndrome/toxic epidermal necrolysis

Science.gov (United States)

... Hung SI. Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis. ... 2012 May 29. Citation on PubMed or Free article on PubMed Central More from Genetics Home Reference ...

The Strip Silicon Photo-Multiplier: An innovation for enhanced time and position measurement

Energy Technology Data Exchange (ETDEWEB)

Doroud, K., E-mail: Katayoun.Doroud@cern.ch [CERN, Geneva (Switzerland); Williams, M.C.S. [CERN, Geneva (Switzerland); INFN, Bologna (Italy); Yamamoto, K. [Solid State Division, Hamamatsu Photonics K.K., Hamamatsu (Japan)

2017-05-01

There is considerable R&D concerning precise time measurement from a variety of detectors, and in particular for the Silicon PhotoMultiplier (SiPM). In this paper we discuss a new geometry for the SiPM in the form of a strip. A strip can be read out at both end, with each end coupled to an individual TDC (time to digital converter). The time difference is related to the position of the firing SPAD along the length of the strip, while the average of the two times gives the time of the hit. Results from the testing of the first prototype Strip SiPMs are presented in this paper.

An in vitro biomechanical comparison of equine proximal interphalangeal joint arthrodesis techniques: an axial positioned dynamic compression plate and two abaxial transarticular cortical screws inserted in lag fashion versus three parallel transarticular cortical screws inserted in lag fashion.

Science.gov (United States)

Sod, Gary A; Riggs, Laura M; Mitchell, Colin F; Hubert, Jeremy D; Martin, George S

2010-01-01

To compare in vitro monotonic biomechanical properties of an axial 3-hole, 4.5 mm narrow dynamic compression plate (DCP) using 5.5 mm cortical screws in conjunction with 2 abaxial transarticular 5.5 mm cortical screws inserted in lag fashion (DCP-TLS) with 3 parallel transarticular 5.5 mm cortical screws inserted in lag fashion (3-TLS) for the equine proximal interphalangeal (PIP) joint arthrodesis. Paired in vitro biomechanical testing of 2 methods of stabilizing cadaveric adult equine forelimb PIP joints. Cadaveric adult equine forelimbs (n=15 pairs). For each forelimb pair, 1 PIP joint was stabilized with an axial 3-hole narrow DCP (4.5 mm) using 5.5 mm cortical screws in conjunction with 2 abaxial transarticular 5.5 mm cortical screws inserted in lag fashion and 1 with 3 parallel transarticular 5.5 mm cortical screws inserted in lag fashion. Five matching pairs of constructs were tested in single cycle to failure under axial compression, 5 construct pairs were tested for cyclic fatigue under axial compression, and 5 construct pairs were tested in single cycle to failure under torsional loading. Mean values for each fixation method were compared using a paired t-test within each group with statistical significance set at Pcycle to failure, of the DCP-TLS fixation were significantly greater than those of the 3-TLS fixation. Mean cycles to failure in axial compression of the DCP-TLS fixation was significantly greater than that of the 3-TLS fixation. The DCP-TLS was superior to the 3-TLS in resisting the static overload forces and in resisting cyclic fatigue. The results of this in vitro study may provide information to aid in the selection of a treatment modality for arthrodesis of the equine PIP joint.

The Effect of Epidermal Structures on Leaf Spectral Signatures of Ice Plants (Aizoaceae

Directory of Open Access Journals (Sweden)

René Hans-Jürgen Heim

2015-12-01

Full Text Available Epidermal structures (ES of leaves are known to affect the functional properties and spectral responses. Spectral studies focused mostly on the effect of hairs or wax layers only. We studied a wider range of different ES and their impact on spectral properties. Additionally, we identified spectral regions that allow distinguishing different ES. We used a field spectrometer to measure ex situ leaf spectral responses from 350 nm–2500 nm. A spectral library for 25 species of the succulent family Aizoaceae was assembled. Five functional types were defined based on ES: flat epidermal cell surface, convex to papillary epidermal cell surface, bladder cells, hairs and wax cover. We tested the separability of ES using partial least squares discriminant analysis (PLS-DA based on the spectral data. Subsequently, variable importance (VIP was calculated to identify spectral regions relevant for discriminating our functional types (classes. Classification performance was high, with a kappa value of 0.9 indicating well-separable spectral classes. VIP calculations identified six spectral regions of increased importance for the classification. We confirmed and extended previous findings regarding the visible-near-infrared spectral region. Our experiments also confirmed that epidermal leaf traits can be classified due to clearly distinguishable spectral signatures across species and genera within the Aizoaceae.

Extraction and stripping of neodymium (III) and dysprosium (III) by TRUEX solvent

International Nuclear Information System (INIS)

Rout, Alok; Venkatesan, K.A.; Antony, M.P.; Srinivasan, T.G.; Vasudeva Rao, P.R.

2009-01-01

McCabe-Thiele diagram for the extraction and stripping of Nd (III) and Dy (III) by TRUEX solvent has been constructed to determine the number of stages required for complete extraction and stripping. (author)

Large-scale module production for the CMS silicon strip tracker

CERN Document Server

Cattai, A

2005-01-01

The Silicon Strip Tracker (SST) for the CMS experiment at LHC consists of 210 m**2 of silicon strip detectors grouped into four distinct sub-systems. We present a brief description of the CMS Tracker, the industrialised detector module production methods and the current status of the SST with reference to some problems encountered at the factories and in the construction centres.

Recent Developments in On-Line Assessment of Steel Strip Properties

International Nuclear Information System (INIS)

Meilland, P.; Kroos, J.; Buchholtz, O. W.; Hartmann, H.-J.

2006-01-01

On-line non-destructive assessment of steel strip properties is a subject of growing interest amongst European manufacturers, as it provides information all along the products length, without slowing down the production. Arcelor, Salzgitter and TKS recently undertook a collective effort to assess the performance of 3 systems for flat carbon steel strips mechanical properties at the exit of galvanizing lines

Leaf structural adaptations of two Limonium miller (Plumbaginales, Plumbaginaceae taxa

Directory of Open Access Journals (Sweden)

Zorić Lana N.

2013-01-01

Full Text Available Limonium gmelinii (Willd. O. Kuntze 1891 subsp. hungaricum (Klokov Soó is Pannonian endemic subspecies that inhabits continental halobiomes, while Limonium anfractum (Salmon Salmon 1924 is one of the indicators of halophyte vegetation of marine rocks and its distribution is restricted to the southern parts of Mediterranean Sea coast. In this work, micromorphological and anatomical characters of leaves of these two Limonium taxa were analyzed, in order to examine their adaptations to specific environmental conditions on saline habitats. The results showed that both taxa exhibited strong xeromorphic adaptations that reflected in flat cell walls of epidermal cells, thick cuticle, high palisade/spongy tissue ratio, high index of palisade cells, the presence of sclereid idioblasts in leaf mesophyll and mechanical tissue by phloem and xylem. Both taxa are crynohalophytes and have salt glands on adaxial and abaxial epidermis for excretion of surplus salt. Relatively high dimensions of mesophyll cells, absence of non-glandular hairs and unprotected stomata slightly increased above the level of epidermal cells, are also adaptations to increased salinity. [Projekat Ministarstva nauke Republike Srbije, br. 173002

Modulation of accelerated repopulation in mouse skin during daily irradiation

International Nuclear Information System (INIS)

Trott, K.-R.; Shirazi, A.; Heasman, F.

1999-01-01

Background and purpose: The timing of acceleration of repopulation in the epidermis during daily irradiation is related to the development of skin erythema and epidermal hypoplasia. Therefore, the relationship between impairment of the epidermal barrier function, the dermal inflammatory response and epidermal hypoplasia with the acceleration of repopulation was investigated.Materials and purpose: Skin fields of approximately 1 cm 2 on the thighs of TUC mice were given five daily fractions of 3 Gy in each week followed by top-up doses at the end of the first, the second, or the third week to determine residual epidermal tolerance and to calculate repopulation rates in weeks 1, 2, or 3. Systemic modulation of repopulation was attempted by daily indomethacine during fractionated irradiation whereas tape stripping or UV-B exposure before the start of fractionated irradiation attempted local modulation. In parallel experiments, the water permeability coefficient of the epidermis was determined ex vivo by studying transepidermal transport of tritiated water.Results: Without modulation, no repopulation was found in the first week of daily fractionation but repopulation compensated 30% of the dose given in week two and 70% of the dose given in week three. Only tape stripping before the start of fractionated irradiation accelerated repopulation in week one. UV-B had no effect on repopulation although it stimulated proliferation as much as tape stripping. Indomethacin did not suppress acceleration of repopulation. A significant increase in transepidermal water loss was found but only after repopulation had already accelerated.Conclusions: Acceleration of repopulation in mouse epidermis during daily-fractionated irradiation is not related to the simultaneous development of an inflammatory response. Also, the loss of the epidermal barrier function is not involved in the development of the acceleration response, which rather seems to be triggered directly by the decreased

Phonon thermal conductance of disordered graphene strips with armchair edges

International Nuclear Information System (INIS)

Shi Lipeng; Xiong Shijie

2009-01-01

Based on the model of lattice dynamics together with the transfer matrix technique, we investigate the thermal conductances of phonons in quasi-one-dimensional disordered graphene strips with armchair edges using Landauer formalism for thermal transport. It is found that the contributions to thermal conductance from the phonon transport near von Hove singularities is significantly suppressed by the presence of disorder, on the contrary to the effect of disorder on phonon modes in other frequency regions. Besides the magnitude, for different widths of the strips, the thermal conductance also shows different temperature dependence. At low temperatures, the thermal conductance displays quantized features of both pure and disordered graphene strips implying that the transmission of phonon modes at low frequencies are almost unaffected by the disorder

Study of surface properties of ATLAS12 strip sensors and their radiation resistance

Science.gov (United States)

Mikestikova, M.; Allport, P. P.; Baca, M.; Broughton, J.; Chisholm, A.; Nikolopoulos, K.; Pyatt, S.; Thomas, J. P.; Wilson, J. A.; Kierstead, J.; Kuczewski, P.; Lynn, D.; Hommels, L. B. A.; Ullan, M.; Bloch, I.; Gregor, I. M.; Tackmann, K.; Hauser, M.; Jakobs, K.; Kuehn, S.; Mahboubi, K.; Mori, R.; Parzefall, U.; Clark, A.; Ferrere, D.; Sevilla, S. Gonzalez; Ashby, J.; Blue, A.; Bates, R.; Buttar, C.; Doherty, F.; McMullen, T.; McEwan, F.; O'Shea, V.; Kamada, S.; Yamamura, K.; Ikegami, Y.; Nakamura, K.; Takubo, Y.; Unno, Y.; Takashima, R.; Chilingarov, A.; Fox, H.; Affolder, A. A.; Casse, G.; Dervan, P.; Forshaw, D.; Greenall, A.; Wonsak, S.; Wormald, M.; Cindro, V.; Kramberger, G.; Mandić, I.; Mikuž, M.; Gorelov, I.; Hoeferkamp, M.; Palni, P.; Seidel, S.; Taylor, A.; Toms, K.; Wang, R.; Hessey, N. P.; Valencic, N.; Hanagaki, K.; Dolezal, Z.; Kodys, P.; Bohm, J.; Stastny, J.; Bevan, A.; Beck, G.; Milke, C.; Domingo, M.; Fadeyev, V.; Galloway, Z.; Hibbard-Lubow, D.; Liang, Z.; Sadrozinski, H. F.-W.; Seiden, A.; To, K.; French, R.; Hodgson, P.; Marin-Reyes, H.; Parker, K.; Jinnouchi, O.; Hara, K.; Sato, K.; Hagihara, M.; Iwabuchi, S.; Bernabeu, J.; Civera, J. V.; Garcia, C.; Lacasta, C.; Marti i Garcia, S.; Rodriguez, D.; Santoyo, D.; Solaz, C.; Soldevila, U.

2016-09-01

A radiation hard n+-in-p micro-strip sensor for the use in the Upgrade of the strip tracker of the ATLAS experiment at the High Luminosity Large Hadron Collider (HL-LHC) has been developed by the "ATLAS ITk Strip Sensor collaboration" and produced by Hamamatsu Photonics. Surface properties of different types of end-cap and barrel miniature sensors of the latest sensor design ATLAS12 have been studied before and after irradiation. The tested barrel sensors vary in "punch-through protection" (PTP) structure, and the end-cap sensors, whose stereo-strips differ in fan geometry, in strip pitch and in edge strip ganging options. Sensors have been irradiated with proton fluences of up to 1×1016 neq/cm2, by reactor neutron fluence of 1×1015 neq/cm2 and by gamma rays from 60Co up to dose of 1 MGy. The main goal of the present study is to characterize the leakage current for micro-discharge breakdown voltage estimation, the inter-strip resistance and capacitance, the bias resistance and the effectiveness of PTP structures as a function of bias voltage and fluence. It has been verified that the ATLAS12 sensors have high breakdown voltage well above the operational voltage which implies that different geometries of sensors do not influence their stability. The inter-strip isolation is a strong function of irradiation fluence, however the sensor performance is acceptable in the expected range for HL-LHC. New gated PTP structure exhibits low PTP onset voltage and sharp cut-off of effective resistance even at the highest tested radiation fluence. The inter-strip capacitance complies with the technical specification required before irradiation and no radiation-induced degradation was observed. A summary of ATLAS12 sensors tests is presented including a comparison of results from different irradiation sites. The measured characteristics are compared with the previous prototype of the sensor design, ATLAS07.

Investigation of Mercury Reduction in Gold Stripping Process at Elevated Temperature

Science.gov (United States)

Pramudya, Irawan

Mercury is present in many gold ores. By processing these ores, there is a potential of emitting mercury to the environment. Carbon regeneration kiln stacks have been observed as one of the primary source of mercury emission into the atmosphere. Before it is recycled back into the carbon in leach (CIL) or carbon in columns (CIC), carbon used in the gold extraction process needs to be reactivated thermally. Emission of mercury can be minimized by keeping the mercury left in the carbon low before it goes to the carbon regeneration kiln stacks. The objective of this study is establishing the optimum elution conditions of mercury cyanide from loaded carbon (which includes the eluent, concentration, temperature and elution time) with respect to gold stripping. Several methods such as acid washing (UNR-100, HCl or ethanol/UNR-100) were investigated prior to the stripping process. Furthermore, conventional pressurized Zadra and modified Zadra were also studied with regards to mercury concentration in the solution and vapor state as well as maximizing the gold stripping from industrial loaded carbon. 7% UNR-100 acid washing of loaded carbon at 80°C was able to wash out approximately 90% of mercury while maintaining the gold adsorption on the carbon (selective washing). The addition of alcohol in the UNR-100 acid washing solution was able to enhance mercury washing from 90% to 97%. Furthermore, mercury stripping using conventional pressurized (cyanide-alkaline) Zadra was best performed at 80°C (minimal amount of mercury reduced and volatilized) whereas using the same process only 40% of gold was stripped, which makes this process not viable. When alcohol was added to the stripping solution, at 80°C, 95% of gold was detected in the solution while keeping the reduction and volatilization of mercury low. The outcome of this study provides a better understanding of mercury behavior during the acid washing and stripping processes so that the risk of mercury exposure and

Performance studies of the CMS Strip Tracker before installation

CERN Document Server

Adam, Wolfgang; Dragicevic, Marko; Friedl, Markus; Fruhwirth, R; Hansel, S; Hrubec, Josef; Krammer, Manfred; Oberegger, Margit; Pernicka, Manfred; Schmid, Siegfried; Stark, Roland; Steininger, Helmut; Uhl, Dieter; Waltenberger, Wolfgang; Widl, Edmund; Van Mechelen, Pierre; Cardaci, Marco; Beaumont, Willem; de Langhe, Eric; de Wolf, Eddi A; Delmeire, Evelyne; Hashemi, Majid; Bouhali, Othmane; Charaf, Otman; Clerbaux, Barbara; Dewulf, Jean-Paul; Elgammal, Sherif; Hammad, Gregory Habib; de Lentdecker, Gilles; Marage, Pierre Edouard; Vander Velde, Catherine; Vanlaer, Pascal; Wickens, John; Adler, Volker; Devroede, Olivier; De Weirdt, Stijn; D'Hondt, Jorgen; Goorens, Robert; Heyninck, Jan; Maes, Joris; Mozer, Matthias Ulrich; Tavernier, Stefaan; Van Lancker, Luc; Van Mulders, Petra; Villella, Ilaria; Wastiels, C; Bonnet, Jean-Luc; Bruno, Giacomo; De Callatay, Bernard; Florins, Benoit; Giammanco, Andrea; Gregoire, Ghislain; Keutgen, Thomas; Kcira, Dorian; Lemaitre, Vincent; Michotte, Daniel; Militaru, Otilia; Piotrzkowski, Krzysztof; Quertermont, L; Roberfroid, Vincent; Rouby, Xavier; Teyssier, Daniel; Daubie, Evelyne; Anttila, Erkki; Czellar, Sandor; Engstrom, Pauli; Harkonen, J; Karimaki, V; Kostesmaa, J; Kuronen, Auli; Lampen, Tapio; Linden, Tomas; Luukka, Panja-Riina; Maenpaa, T; Michal, Sebastien; Tuominen, Eija; Tuominiemi, Jorma; Ageron, Michel; Baulieu, Guillaume; Bonnevaux, Alain; Boudoul, Gaelle; Chabanat, Eric; Chabert, Eric Christian; Chierici, Roberto; Contardo, Didier; Della Negra, Rodolphe; Dupasquier, Thierry; Gelin, Georges; Giraud, Noël; Guillot, Gérard; Estre, Nicolas; Haroutunian, Roger; Lumb, Nicholas; Perries, Stephane; Schirra, Florent; Trocme, Benjamin; Vanzetto, Sylvain; Agram, Jean-Laurent; Blaes, Reiner; Drouhin, Frédéric; Ernenwein, Jean-Pierre; Fontaine, Jean-Charles; Berst, Jean-Daniel; Brom, Jean-Marie; Didierjean, Francois; Goerlach, Ulrich; Graehling, Philippe; Gross, Laurent; Hosselet, J; Juillot, Pierre; Lounis, Abdenour; Maazouzi, Chaker; Olivetto, Christian; Strub, Roger; Van Hove, Pierre; Anagnostou, Georgios; Brauer, Richard; Esser, Hans; Feld, Lutz; Karpinski, Waclaw; Klein, Katja; Kukulies, Christoph; Olzem, Jan; Ostapchuk, Andrey; Pandoulas, Demetrios; Pierschel, Gerhard; Raupach, Frank; Schael, Stefan; Schwering, Georg; Sprenger, Daniel; Thomas, Maarten; Weber, Markus; Wittmer, Bruno; Wlochal, Michael; Beissel, Franz; Bock, E; Flugge, G; Gillissen, C; Hermanns, Thomas; Heydhausen, Dirk; Jahn, Dieter; Kaussen, Gordon; Linn, Alexander; Perchalla, Lars; Poettgens, Michael; Pooth, Oliver; Stahl, Achim; Zoeller, Marc Henning; Buhmann, Peter; Butz, Erik; Flucke, Gero; Hamdorf, Richard Helmut; Hauk, Johannes; Klanner, Robert; Pein, Uwe; Schleper, Peter; Steinbruck, G; Blum, P; De Boer, Wim; Dierlamm, Alexander; Dirkes, Guido; Fahrer, Manuel; Frey, Martin; Furgeri, Alexander; Hartmann, Frank; Heier, Stefan; Hoffmann, Karl-Heinz; Kaminski, Jochen; Ledermann, Bernhard; Liamsuwan, Thiansin; Muller, S; Muller, Th; Schilling, Frank-Peter; Simonis, Hans-Jürgen; Steck, Pia; Zhukov, Valery; Cariola, P; De Robertis, Giuseppe; Ferorelli, Raffaele; Fiore, Luigi; Preda, M; Sala, Giuliano; Silvestris, Lucia; Tempesta, Paolo; Zito, Giuseppe; Creanza, Donato; De Filippis, Nicola; De Palma, Mauro; Giordano, Domenico; Maggi, Giorgio; Manna, Norman; My, Salvatore; Selvaggi, Giovanna; Albergo, Sebastiano; Chiorboli, Massimiliano; Costa, Salvatore; Galanti, Mario; Giudice, Nunzio; Guardone, Nunzio; Noto, Francesco; Potenza, Renato; Saizu, Mirela Angela; Sparti, V; Sutera, Concetta; Tricomi, Alessia; Tuve, Cristina; Brianzi, Mirko; Civinini, Carlo; Maletta, Fernando; Manolescu, Florentina; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Broccolo, B; Ciulli, Vitaliano; D'Alessandro, Raffaello; Focardi, Ettore; Frosali, Simone; Genta, Chiara; Landi, Gregorio; Lenzi, Piergiulio; Macchiolo, Anna; Magini, Nicolo; Parrini, Giuliano; Scarlini, Enrico; Cerati, Giuseppe Benedetto; Azzi, Patrizia; Bacchetta, Nicola; Candelori, Andrea; Dorigo, Tommaso; Kaminsky, A; Karaevski, S; Khomenkov, Volodymyr; Reznikov, Sergey; Tessaro, Mario; Bisello, Dario; De Mattia, Marco; Giubilato, Piero; Loreti, Maurizio; Mattiazzo, Serena; Nigro, Massimo; Paccagnella, Alessandro; Pantano, Devis; Pozzobon, Nicola; Tosi, Mia; Bilei, Gian Mario; Checcucci, Bruno; Fano, Livio; Servoli, Leonello; Ambroglini, Filippo; Babucci, Ezio; Benedetti, Daniele; Biasini, Maurizio; Caponeri, Benedetta; Covarelli, Roberto; Giorgi, Marco; Lariccia, Paolo; Mantovani, Giancarlo; Marcantonini, Marta; Postolache, Vasile; Santocchia, Attilio; Spiga, Daniele; Bagliesi, Giuseppe; Balestri, Gabriele; Berretta, Luca; Bianucci, S; Boccali, Tommaso; Bosi, Filippo; Bracci, Fabrizio; Castaldi, Rino; Ceccanti, Marco; Cecchi, Roberto; Cerri, Claudio; Cucoanes, Andi Sebastian; Dell'Orso, Roberto; Dobur, Didar; Dutta, Suchandra; Giassi, Alessandro; Giusti, Simone; Kartashov, Dmitry; Kraan, Aafke; Lomtadze, Teimuraz; Lungu, George-Adrian; Magazzu, Guido; Mammini, Paolo; Mariani, Filippo; Martinelli, Giovanni; Moggi, Andrea; Palla, Fabrizio; Palmonari, Francesco; Petragnani, Giulio; Profeti, Alessandro; Raffaelli, Fabrizio; Rizzi, Domenico; Sanguinetti, Giulio; Sarkar, Subir; Sentenac, Daniel; Serban, Alin Titus; Slav, Adrian; Soldani, A; Spagnolo, Paolo; Tenchini, Roberto; Tolaini, Sergio; Venturi, Andrea; Verdini, Piero Giorgio; Vos, Marcel; Zaccarelli, Luciano; Avanzini, Carlo; Basti, Andrea; Benucci, Leonardo; Bocci, Andrea; Cazzola, Ugo; Fiori, Francesco; Linari, Stefano; Massa, Maurizio; Messineo, Alberto; Segneri, Gabriele; Tonelli, Guido; Azzurri, Paolo; Bernardini, Jacopo; Borrello, Laura; Calzolari, Federico; Foa, Lorenzo; Gennai, Simone; Ligabue, Franco; Petrucciani, Giovanni; Rizzi, Andrea; Yang, Zong-Chang; Benotto, Franco; Demaria, Natale; Dumitrache, Floarea; Farano, R; Borgia, Maria Assunta; Castello, Roberto; Costa, Marco; Migliore, Ernesto; Romero, Alessandra; Abbaneo, Duccio; Abbas, M; Ahmed, Ijaz; Akhtar, I; Albert, Eric; Bloch, Christoph; Breuker, Horst; Butt, Shahid Aleem; Buchmuller, Oliver; Cattai, Ariella; Delaere, Christophe; Delattre, Michel; Edera, Laura Maria; Engstrom, Pauli; Eppard, Michael; Gateau, Maryline; Gill, Karl; Giolo-Nicollerat, Anne-Sylvie; Grabit, Robert; Honma, Alan; Huhtinen, Mika; Kloukinas, Kostas; Kortesmaa, Jarmo; Kottelat, Luc-Joseph; Kuronen, Auli; Leonardo, Nuno; Ljuslin, Christer; Mannelli, Marcello; Masetti, Lorenzo; Marchioro, Alessandro; Mersi, Stefano; Michal, Sebastien; Mirabito, Laurent; Muffat-Joly, Jeannine; Onnela, Antti; Paillard, Christian; Pal, Imre; Pernot, Jean-Francois; Petagna, Paolo; Petit, Patrick; Piccut, C; Pioppi, Michele; Postema, Hans; Ranieri, Riccardo; Ricci, Daniel; Rolandi, Gigi; Ronga, Frederic Jean; Sigaud, Christophe; Syed, A; Siegrist, Patrice; Tropea, Paola; Troska, Jan; Tsirou, Andromachi; Vander Donckt, Muriel; Vasey, François; Alagoz, Enver; Amsler, Claude; Chiochia, Vincenzo; Regenfus, Christian; Robmann, Peter; Rochet, Jacky; Rommerskirchen, Tanja; Schmidt, Alexander; Steiner, Stefan; Wilke, Lotte; Church, Ivan; Cole, Joanne; Coughlan, John A; Gay, Arnaud; Taghavi, S; Tomalin, Ian R; Bainbridge, Robert; Cripps, Nicholas; Fulcher, Jonathan; Hall, Geoffrey; Noy, Matthew; Pesaresi, Mark; Radicci, Valeria; Raymond, David Mark; Sharp, Peter; Stoye, Markus; Wingham, Matthew; Zorba, Osman; Goitom, Israel; Hobson, Peter R; Reid, Ivan; Teodorescu, Liliana; Hanson, Gail; Jeng, Geng-Yuan; Liu, Haidong; Pasztor, Gabriella; Satpathy, Asish; Stringer, Robert; Mangano, Boris; Affolder, K; Affolder, T; Allen, Andrea; Barge, Derek; Burke, Samuel; Callahan, D; Campagnari, Claudio; Crook, A; D'Alfonso, Mariarosaria; Dietch, J; Garberson, Jeffrey; Hale, David; Incandela, H; Incandela, Joe; Jaditz, Stephen; Kalavase, Puneeth; Kreyer, Steven Lawrence; Kyre, Susanne; Lamb, James; Mc Guinness, C; Mills, C; Nguyen, Harold; Nikolic, Milan; Lowette, Steven; Rebassoo, Finn; Ribnik, Jacob; Richman, Jeffrey; Rubinstein, Noah; Sanhueza, S; Shah, Yousaf Syed; Simms, L; Staszak, D; Stoner, J; Stuart, David; Swain, Sanjay Kumar; Vlimant, Jean-Roch; White, Dean; Ulmer, Keith; Wagner, Stephen Robert; Bagby, Linda; Bhat, Pushpalatha C; Burkett, Kevin; Cihangir, Selcuk; Gutsche, Oliver; Jensen, Hans; Johnson, Mark; Luzhetskiy, Nikolay; Mason, David; Miao, Ting; Moccia, Stefano; Noeding, Carsten; Ronzhin, Anatoly; Skup, Ewa; Spalding, William J; Spiegel, Leonard; Tkaczyk, Slawek; Yumiceva, Francisco; Zatserklyaniy, Andriy; Zerev, E; Anghel, Ioana Maria; Bazterra, Victor Eduardo; Gerber, Cecilia Elena; Khalatian, S; Shabalina, Elizaveta; Baringer, Philip; Bean, Alice; Chen, Jie; Hinchey, Carl Louis; Martin, Christophe; Moulik, Tania; Robinson, Richard; Gritsan, Andrei; Lae, Chung Khim; Tran, Nhan Viet; Everaerts, Pieter; Hahn, Kristan Allan; Harris, Philip; Nahn, Steve; Rudolph, Matthew; Sung, Kevin; Betchart, Burton; Demina, Regina; Gotra, Yury; Korjenevski, Sergey; Miner, Daniel Carl; Orbaker, Douglas; Christofek, Leonard; Hooper, Ryan; Landsberg, Greg; Nguyen, Duong; Narain, Meenakshi; Speer, Thomas; Tsang, Ka Vang

2009-01-01

In March 2007 the assembly of the Silicon Strip Tracker was completed at the Tracker Integration Facility at CERN. Nearly 15% of the detector was instrumented using cables, fiber optics, power supplies, and electronics intended for the operation at the LHC. A local chiller was used to circulate the coolant for low temperature operation. In order to understand the efficiency and alignment of the strip tracker modules, a cosmic ray trigger was implemented. From March through July 4.5 million triggers were recorded. This period, referred to as the Sector Test, provided practical experience with the operation of the Tracker, especially safety, data acquisition, power, and cooling systems. This paper describes the performance of the strip system during the Sector Test, which consisted of five distinct periods defined by the coolant temperature. Significant emphasis is placed on comparisons between the data and results from Monte Carlo studies.

HLA-B Sequencing in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Science.gov (United States)

2017-03-03

Stevens -Johnson Syndrome and Toxic Epidermal Necrolysis Brittany L. Lenz, MD, Andrew T. Patterson, MD, Amanda J . Laska, MD, Patrick J . Brown, MD, and...59 MDW/SGVU SUBJECT: Professional Presentation Approval 8 DEC 2016 1. Your paper, entitled HLA-B Sequencing in Patients with Stevens -Johnson...PATIENTS WITH STEVENS -JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROL YSIS 2. FUNDING RECEIVED FOR THIS STUDY? DYES rgj NO FUNDING SOURCE: I I 3. IS THIS

Clinical Studies on conformal radiotherapy combined with epidermal ...

African Journals Online (AJOL)

Purpose: To study the effect of conformal radiotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in the second-line treatment of non-small cell lung cancer (NSCLC). Methods: A total of 316 patients attending Shanghai Pulmonary Hospital affiliated to Tongji University, were divided ...

Deep percolation in greenhouse-cultivated celery using the technique of subsurface film strips placement

Directory of Open Access Journals (Sweden)

Zhida Du

2014-05-01

Full Text Available To reduce the deep percolation during greenhouse vegetable cultivation, the technique of subsurface film strips placement was tested. Four treatments with two kinds of cross-sections (flat and U-shaped and two different spacings (10 cm and 40 cm of subsurface film strips were arranged in a greenhouse before planting celery. At the same time, a non-film treatment was arranged for comparison. Soil water content was measured and irrigation time was adjusted according to the soil water content. Evapotranspiration of celery during growth was calculated by the method of energy balance and the deep percolation was calculated by the equation of water balance. Deep percolation was reduced in all experimental treatments. Greater reduction in deep percolation was observed when using U-shaped cross-section strips compared with that using the flat cross-section strips. In addition, greater reduction in deep percolation was observed when the spacing between the film strips was smaller. The results of this test showed that the technique of subsurface film strips placement can reduce deep percolation and conserve irrigation water for greenhouse vegetables cultivation. However, the optimal layout variables for the use of the technique of subsurface film strips placement need further experimental and numerical analysis.

Epidermal growth factor receptor expression in urinary bladder cancer

Directory of Open Access Journals (Sweden)

Dayalu S.L. Naik

2011-01-01

Full Text Available Objective : To evaluate the expression pattern of epidermal growth factor receptor (EGFR in urinary bladder cancer and its association with human epidermal growth factor receptor 2 (HER2, epidermal growth factor (EGF, interleukin-6 (IL-6, and high risk human papilloma virus (HPV types 16 and 18. Materials and Methods : Thirty cases of urothelial carcinoma were analyzed. EGFR, HER2, EGF, and IL-6 expressions in the tissue were evaluated by immunohistochemical staining. For HPV, DNA from tissue samples was extracted and detection of HPV was done by PCR technique. Furthermore, evaluation of different intracellular molecules associated with EGFR signaling pathways was performed by the western blot method using lysates from various cells and tissues. Results : In this study, the frequencies of immunopositivity for EGFR, HER2, EGF, and IL-6 were 23%, 60%, 47%, and 80%, respectively. No cases were positive for HPV-18, whereas HPV-16 was detected in 10% cases. Overall, expression of EGFR did not show any statistically significant association with the studied parameters. However, among male patients, a significant association was found only between EGFR and HER2. Conclusions : Overexpression of EGFR and/or HER2, two important members of the same family of growth factor receptors, was observed in a considerable proportion of cases. Precise knowledge in this subject would be helpful to formulate a rational treatment strategy in patients with urinary bladder cancer.

Si-strip photon counting detectors for contrast-enhanced spectral mammography

Science.gov (United States)

Chen, Buxin; Reiser, Ingrid; Wessel, Jan C.; Malakhov, Nail; Wawrzyniak, Gregor; Hartsough, Neal E.; Gandhi, Thulasi; Chen, Chin-Tu; Iwanczyk, Jan S.; Barber, William C.

2015-08-01

We report on the development of silicon strip detectors for energy-resolved clinical mammography. Typically, X-ray integrating detectors based on scintillating cesium iodide CsI(Tl) or amorphous selenium (a-Se) are used in most commercial systems. Recently, mammography instrumentation has been introduced based on photon counting Si strip detectors. The required performance for mammography in terms of the output count rate, spatial resolution, and dynamic range must be obtained with sufficient field of view for the application, thus requiring the tiling of pixel arrays and particular scanning techniques. Room temperature Si strip detector, operating as direct conversion x-ray sensors, can provide the required speed when connected to application specific integrated circuits (ASICs) operating at fast peaking times with multiple fixed thresholds per pixel, provided that the sensors are designed for rapid signal formation across the X-ray energy ranges of the application. We present our methods and results from the optimization of Si-strip detectors for contrast enhanced spectral mammography. We describe the method being developed for quantifying iodine contrast using the energy-resolved detector with fixed thresholds. We demonstrate the feasibility of the method by scanning an iodine phantom with clinically relevant contrast levels.

[Penile augmentation and elongation using autologous dermal-fat strip grafting].

Science.gov (United States)

Yang, Zhe; Li, Yang-qun; Tang, Yong; Chen, Wen; Li, Qiang; Zhou, Chuan-de; Zhao, Mu-xin; Hu, Chun-mei

2012-05-01

To investigate the effect of autologous dermal-fat strip grafting in penile augmentation and elongation. From May 2004 to December 2010, 24 patients underwent penile enhancement with free dermal-fat strip grafting. Through suprapubic incision, the superior suspensory ligament and part deep suspensory ligament are cutted off to lengthen the penis. The resulted dead space is filled with the autologous dermal-fat strip (6.0-9.5 cm in length, 1.2-1.5 cm in width and 0.6-0.8 cm in depth) to enhance the penis. Primary healing was achieved in 23 cases. Incisional fat liquefaction happened in one case which healed after dressing change. The penile appearance was satisfactory both at rest or erection. The penile length and circumference increased by 2.5-4.8 cm (average, 3.2 cm) and 1.8-3.0 cm (average, 2.4 cm), respectively. 18 patients were followed up for 3 months to 5 years. All the patients were satisfactory on the cosmetic and functional results. No complication happened. It is safe and effective for penile augmention and elongation with autologous dermal-fat strip grafting and disconnection of penile suspensory ligament.

Beam test of CSES silicon strip detector module

Science.gov (United States)

Zhang, Da-Li; Lu, Hong; Wang, Huan-Yu; Li, Xin-Qiao; Xu, Yan-Bing; An, Zheng-Hua; Yu, Xiao-xia; Wang, Hui; Shi, Feng; Wang, Ping; Zhao, Xiao-Yun

2017-05-01

The silicon-strip tracker of the China Seismo-Electromagnetic Satellite (CSES) consists of two double-sided silicon strip detectors (DSSDs) which provide incident particle tracking information. A low-noise analog ASIC VA140 was used in this study for DSSD signal readout. A beam test on the DSSD module was performed at the Beijing Test Beam Facility of the Beijing Electron Positron Collider (BEPC) using a 400-800 MeV/c proton beam. The pedestal analysis results, RMSE noise, gain correction, and intensity distribution of incident particles of the DSSD module are presented. Supported by the XXX Civil Space Programme

Predicting human epidermal melanin concentrations for different skin tones

CSIR Research Space (South Africa)

Smit, Jacoba E

2011-07-01

Full Text Available epidermal melanin concentrations for different skin tones JE Smit 1 , AE Karsten 2 , RW Sparrow 1 1 CSIR Biosciences, Pretoria, South Africa 2 CSIR National Laser Centre, Pretoria, South Africa Author e-mail address: KSmit...

Epidermal Nevus Syndrome Associated with Brain Malformations and Medulloblastoma

Directory of Open Access Journals (Sweden)

J Gordon Millichap

2013-01-01

Full Text Available Researchers at Juntendo University and Tokyo Women’s Medical University, Japan; and University of California, San Francisco, Ca, report a male infant with epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma.

Urine Test Strips to Exclude Cerebral Spinal Fluid Blood

Directory of Open Access Journals (Sweden)

Marshall, Robin A

2011-02-01

Full Text Available Introduction: Determining the presence or absence of red blood cells (RBC or their breakdown products in cerebrospinal fluid (CSF is essential for the evaluation of subarachnoid hemorrhage (SAH in headache patients. Current methodology for finding blood in the CSF is either spectrophotometric detection of pigment, which is time consuming and labor intensive, or visual assesment of samples for color change (xanthochromia, which is inaccurate. Bayer Multistix® urine test strips are designed to test urine for RBC by detecting the presence of hemoglobin. The aim of this pilot study was to evaluate the perfomance of urine reagent test strips for ruling out the presence of RBC in CSF.Methods: We compared color changes on Multistix® urine test strips to the standard of spectrophotometric absorbtion at 415nm and initial RBC counts in 138 visually clear CSF samples.Results: We performed Pearson Chi-Square and likelihood ratios on the results and found a correlation between a negative result on the urine test strip and less than 5 RBC per high power field and a spectrophotometric absorbance of less than 0.02% at 415nm in a CSF sample.Conclusion: These results warrant further investigation in the form of a prospective clinical validation as it may alter the emergency department evaluation for SAH. [West J Emerg Med. 2011;12(1:63-66.

Guiding spoof surface plasmon polaritons by infinitely thin grooved metal strip

Directory of Open Access Journals (Sweden)

Xiang Wan

2014-04-01

Full Text Available In this paper, the propagation characteristics of spoof surface plasmon polaritons (SPPs on infinitely thin corrugated metal strips are theoretically analyzed. Compared with the situations of infinitely thick lateral thickness, the infinitely thin lateral thickness leads to lower plasma frequency according to the analyses. The propagation lengths and the binding capacity of the spoof SPPs are evaluated based on the derived dispersion equation. The effects of different lateral thicknesses are also investigated. At the end, a surface wave splitter is presented using infinitely thin corrugated metal strip. Other functional planar or flexible devices can also be designed using these metal strips in microwave or terahertz regimes.

First thin AC-coupled silicon strip sensors on 8-inch wafers

Energy Technology Data Exchange (ETDEWEB)

Bergauer, T., E-mail: thomas.bergauer@oeaw.ac.at [Institute of High Energy Physics of the Austrian Academy of Sciences, Nikolsdorfer Gasse 18, 1050 Wien (Vienna) (Austria); Dragicevic, M.; König, A. [Institute of High Energy Physics of the Austrian Academy of Sciences, Nikolsdorfer Gasse 18, 1050 Wien (Vienna) (Austria); Hacker, J.; Bartl, U. [Infineon Technologies Austria AG, Siemensstrasse 2, 9500 Villach (Austria)

2016-09-11

The Institute of High Energy Physics (HEPHY) in Vienna and the semiconductor manufacturer Infineon Technologies Austria AG developed a production process for planar AC-coupled silicon strip sensors manufactured on 200 μm thick 8-inch p-type wafers. In late 2015, the first wafers were delivered featuring the world's largest AC-coupled silicon strip sensors. Detailed electrical measurements were carried out at HEPHY, where single strip and global parameters were measured. Mechanical studies were conducted and the long-term behavior was investigated using a climate chamber. Furthermore, the electrical properties of various test structures were investigated to validate the quality of the manufacturing process.

Robust skull stripping using multiple MR image contrasts insensitive to pathology.

Science.gov (United States)

Roy, Snehashis; Butman, John A; Pham, Dzung L

2017-02-01

Automatic skull-stripping or brain extraction of magnetic resonance (MR) images is often a fundamental step in many neuroimage processing pipelines. The accuracy of subsequent image processing relies on the accuracy of the skull-stripping. Although many automated stripping methods have been proposed in the past, it is still an active area of research particularly in the context of brain pathology. Most stripping methods are validated on T 1 -w MR images of normal brains, especially because high resolution T 1 -w sequences are widely acquired and ground truth manual brain mask segmentations are publicly available for normal brains. However, different MR acquisition protocols can provide complementary information about the brain tissues, which can be exploited for better distinction between brain, cerebrospinal fluid, and unwanted tissues such as skull, dura, marrow, or fat. This is especially true in the presence of pathology, where hemorrhages or other types of lesions can have similar intensities as skull in a T 1 -w image. In this paper, we propose a sparse patch based Multi-cONtrast brain STRipping method (MONSTR), 2 where non-local patch information from one or more atlases, which contain multiple MR sequences and reference delineations of brain masks, are combined to generate a target brain mask. We compared MONSTR with four state-of-the-art, publicly available methods: BEaST, SPECTRE, ROBEX, and OptiBET. We evaluated the performance of these methods on 6 datasets consisting of both healthy subjects and patients with various pathologies. Three datasets (ADNI, MRBrainS, NAMIC) are publicly available, consisting of 44 healthy volunteers and 10 patients with schizophrenia. Other three in-house datasets, comprising 87 subjects in total, consisted of patients with mild to severe traumatic brain injury, brain tumors, and various movement disorders. A combination of T 1 -w, T 2 -w were used to skull-strip these datasets. We show significant improvement in stripping

Pros and cons of flowers strips for farmers. A review

Directory of Open Access Journals (Sweden)

Uyttenbroeck, R.

2016-01-01

Full Text Available Description of the subject. To counteract environmental problems due to agricultural intensification, European farmers can apply agri-environmental schemes in their fields. Flower strips are one example of these schemes, with the aim of supporting biodiversity, leading to an increase in "useful" species groups such as pollinators for crop pollination and natural enemies for pest control. However, to our knowledge, a complete appraisal of the pros and cons of flower strips, from a farmer's point of view, does not yet exist. It is proposed that better and more complete information could increase the adoption and implementation of such agri-environmental schemes. Objectives. This study aims 1 to assess the pros and cons of flower strips, from a farmer's point of view, and 2 to highlight the knowledge gaps that exist in the scientific literature, for the different types of pros and cons. Method. We listed the different components of the appraisal of pros and cons and conducted a systematic screening of the scientific literature on flower strips and these components. Results. The largest part of the 31 selected studies was concerning agronomical and ecological processes, such as pollination and animal pest control. Most of them indicated positive effects of flower strips. For many components of the appraisal, mostly economic and social ones, few or no studies were found. Conclusions. While a positive balance of pros and cons, from a farmer's point of view, came from our literature screening, large research gaps still remain and more research is required, especially in the economic and social components of the evaluation.

Flexible Faraday Cage with a Twist: Surface Charge on a Möbius Strip

Science.gov (United States)

Stewart, Seán

2007-05-01

Once an intriguing topological novelty known only to mathematicians, the Möbius strip has become a source of fascination and inspiration to the layperson and artist alike. Principal among its features are the two strange properties that the Möbius strip is a surface with only one side and one edge. A Möbius strip is readily formed by taking a long rectangular strip of paper and giving one of its ends a half twist before joining it to its other end (see Fig. 1). Given its simplicity, I hoped to profit from its appealing yet counterintuitive nature by designing a simple demonstration experiment that would reveal the intrinsic physical difference between one- and two-sided surfaces.

Performance of a large-area GEM detector read out with wide radial zigzag strips

Energy Technology Data Exchange (ETDEWEB)

Zhang, Aiwu, E-mail: azhang@fit.edu; Bhopatkar, Vallary; Hansen, Eric; Hohlmann, Marcus; Khanal, Shreeya; Phipps, Michael; Starling, Elizabeth; Twigger, Jessie; Walton, Kimberly

2016-03-01

A 1-meter-long trapezoidal Triple-GEM detector with wide readout strips was tested in hadron beams at the Fermilab Test Beam Facility in October 2013. The readout strips have a special zigzag geometry and run radially with an azimuthal pitch of 1.37 mrad to measure the azimuthal ϕ-coordinate of incident particles. The zigzag geometry of the readout reduces the required number of electronic channels by a factor of three compared to conventional straight readout strips while preserving good angular resolution. The average crosstalk between zigzag strips is measured to be an acceptable 5.5%. The detection efficiency of the detector is (98.4±0.2)%. When the non-linearity of the zigzag-strip response is corrected with track information, the angular resolution is measured to be (193±3) μrad, which corresponds to 14% of the angular strip pitch. Multiple Coulomb scattering effects are fully taken into account in the data analysis with the help of a stand-alone Geant4 simulation that estimates interpolated track errors.

Design and development of equipment for laser wire stripping

Science.gov (United States)

Iceland, W. F.

1977-01-01

Three laser wire strippers have been built for the stripping of Kapton-insulated wire, the baseline wire of the space shuttle orbiter. The strippers are: (1) a bench-model stripper powered with a cw CO2 10.6-micron laser, (2) a hand-held stripper powered with a cw 1.06-micron Nd-YAG laser with an output of 5-7 watts, and (3) a hand-held stripper with a five-inch-long CO2 laser inside the stripping head.

An Optical Test Strip for the Detection of Benzoic Acid in Food

Directory of Open Access Journals (Sweden)

Fatimah Abu Bakar

2011-07-01

Full Text Available Fabrication of a test strip for detection of benzoic acid was successfully implemented by immobilizing tyrosinase, phenol and 3-methyl-2-benzothiazolinone hydrazone (MBTH onto filter paper using polystyrene as polymeric support. The sensing scheme was based on the decreasing intensity of the maroon colour of the test strip when introduced into benzoic acid solution. The test strip was characterized using optical fiber reflectance and has maximum reflectance at 375 nm. It has shown a highly reproducible measurement of benzoic acid with a calculated RSD of 0.47% (n = 10. The detection was optimized at pH 7. A linear response of the biosensor was obtained in 100 to 700 ppm of benzoic acid with a detection limit (LOD of 73.6 ppm. At 1:1 ratio of benzoic acid to interfering substances, the main interfering substance is boric acid. The kinetic analyses show that, the inhibition of benzoic is competitive inhibitor and the inhibition constant (Ki is 52.9 ppm. The activity of immobilized tyrosinase, phenol, and MBTH in the test strip was fairly sustained during 20 days when stored at 3 °C. The developed test strip was used for detection of benzoic acid in food samples and was observed to have comparable results to the HPLC method, hence the developed test strip can be used as an alternative to HPLC in detecting benzoic acid in food products.

ISM stripping from cluster galaxies and inhomogeneities in cooling flows

Science.gov (United States)

Soker, Noam; Bregman, Joel N.; Sarazin, Craig L.

1990-01-01

Analyses of the x ray surface brightness profiles of cluster cooling flows suggest that the mass flow rate decreases towards the center of the cluster. It is often suggested that this decrease results from thermal instabilities, in which denser blobs of gas cool rapidly and drop below x ray emitting temperatures. If the seeds for the thermal instabilities are entropy perturbations, these perturbations must enter the flow already in the nonlinear regime. Otherwise, the blobs would take too long to cool. Here, researchers suggest that such nonlinear perturbations might start as blobs of interstellar gas which are stripped out of cluster galaxies. Assuming that most of the gas produced by stellar mass loss in cluster galaxies is stripped from the galaxies, the total rate of such stripping is roughly M sub Interstellar Matter (ISM) approx. 100 solar mass yr(-1). It is interesting that the typical rates of cooling in cluster cooling flows are M sub cool approx. 100 solar mass yr(-1). Thus, it is possible that a substantial portion of the cooling gas originates as blobs of interstellar gas stripped from galaxies. The magnetic fields within and outside of the low entropy perturbations can help to maintain their identities, both by suppressing thermal conduction and through the dynamical effects of magnetic tension. One significant question concerning this scenario is: Why are cooling flows seen only in a fraction of clusters, although one would expect gas stripping to be very common. It may be that the density perturbations only survive and cool efficiently in clusters with a very high intracluster gas density and with the focusing effect of a central dominant galaxy. Inhomogeneities in the intracluster medium caused by the stripping of interstellar gas from galaxies can have a number of other effects on clusters. For example, these density fluctuations may disrupt the propagation of radio jets through the intracluster gas, and this may be one mechanism for producing Wide

Retrospective Study of Epidermal Parasitic Skin Diseases amongst ...

African Journals Online (AJOL)

ADOWIE PERE

ABSTRACT: A ten year retrospective study (1997-2006) was undertaken to determine the prevalence of. Epidermal Parasitic Skin Diseases (EPSD) among out-patients from the skin diseases hospital in Maiduguri, Borno state. Out of 10,000 out-patients examined during the study period, 3527(35.27%) where infected with ...

AC losses in a type II superconductor strip with inhomogeneous critical current distribution

International Nuclear Information System (INIS)

Tsukamoto, Osami

2005-01-01

Analytical formulae derived by Brandt and Indenbom (1993 Phys. Rev. B 48 12893-906) and Norris (1970 J. Phys. D: Appl. Phys. 3 489-507) are often used to calculate the magnetization and AC transport current losses in HTS strip conductors, respectively. In these formulae, homogeneous distribution of critical sheet current density σ c in the strip is assumed. However, it is considered that σ c distributions are inhomogeneous in actual HTS strips and that the inhomogeneous σ c distributions cause deviations of the measured AC loss data of actual HTS strips from those formulae. A semi-analytical method to calculate AC transport current and magnetization losses is derived for a type II superconductor strip with inhomogeneous distribution of σ c in the direction of the strip width. The method is derived modifying the analysis of Brandt et al. The validity of the semi-analytical method is shown by comparing the results calculated by this method with those calculated by the Norris and Brandt formulae and by a different method of our previous work and also with experimental data. Moreover, it is shown that the deviation of the measured data from the Norris and Brandt models can be estimated by assuming proper σ c distributions

Simple preparation of plant epidermal tissue for laser microdissection and downstream quantitative proteome and carbohydrate analysis

Directory of Open Access Journals (Sweden)

Christian eFalter

2015-03-01

Full Text Available The outwardly directed cell wall and associated plasma membrane of epidermal cells represent the first layers of plant defense against intruding pathogens. Cell wall modifications and the formation of defense structures at sites of attempted pathogen penetration are decisive for plant defense. A precise isolation of these stress-induced structures would allow a specific analysis of regulatory mechanism and cell wall adaption. However, methods for large-scale epidermal tissue preparation from the model plant Arabidopsis thaliana, which would allow proteome and cell wall analysis of complete, laser-microdissected epidermal defense structures, have not been provided. We developed the adhesive tape – liquid cover glass technique for simple leaf epidermis preparation from A. thaliana, which is also applicable on grass leaves. This method is compatible with subsequent staining techniques to visualize stress-related cell wall structures, which were precisely isolated from the epidermal tissue layer by laser microdissection coupled to laser pressure catapulting. We successfully demonstrated that these specific epidermal tissue samples could be used for quantitative downstream proteome and cell wall analysis. The development of the adhesive tape – liquid cover glass technique for simple leaf epidermis preparation and the compatibility to laser microdissection and downstream quantitative analysis opens new possibilities in the precise examination of stress- and pathogen-related cell wall structures in epidermal cells. Because the developed tissue processing is also applicable on A. thaliana, well-established, model pathosystems that include the interaction with powdery mildews can be studied to determine principal regulatory mechanisms in plant-microbe interaction with their potential outreach into crop breeding.

The ties that bind? Galactic magnetic fields and ram pressure stripping

Energy Technology Data Exchange (ETDEWEB)

Tonnesen, Stephanie; Stone, James, E-mail: stonnes@astro.princeton.edu, E-mail: jstone@astro.princeton.edu [Department of Astrophysics, Princeton University, Peyton Hall, Princeton, NJ 08544 (United States)

2014-11-10

One process affecting gas-rich cluster galaxies is ram pressure stripping (RPS), i.e., the removal of galactic gas through direct interaction with the intracluster medium (ICM). Galactic magnetic fields may have an important impact on the stripping rate and tail structure. We run the first magnetohydrodynamic (MHD) simulations of RPS that include a galactic magnetic field, using 159 pc resolution throughout our entire domain in order to resolve mixing throughout the tail. We find very little difference in the total amount of gas removed from the unmagnetized and magnetized galaxies, although a magnetic field with a radial component will initially accelerate stripped gas more quickly. In general, we find that magnetic fields in the disk lead to slower velocities in the stripped gas near the disk and faster velocities farther from the disk. We also find that magnetic fields in the galactic gas lead to larger unmixed structures in the tail. Finally, we discuss whether ram pressure stripped tails can magnetize the ICM. We find that the total magnetic energy density grows as the tail lengthens, likely through turbulence. There are μG-strength fields in the tail in all of our MHD runs, which survive to at least 100 kpc from the disk (the edge of our simulated region), indicating that the area-filling factor of magnetized tails in a cluster could be large.

The Ties that Bind? Galactic Magnetic Fields and Ram Pressure Stripping

Science.gov (United States)

Tonnesen, Stephanie; Stone, James

2014-11-01

One process affecting gas-rich cluster galaxies is ram pressure stripping (RPS), i.e., the removal of galactic gas through direct interaction with the intracluster medium (ICM). Galactic magnetic fields may have an important impact on the stripping rate and tail structure. We run the first magnetohydrodynamic (MHD) simulations of RPS that include a galactic magnetic field, using 159 pc resolution throughout our entire domain in order to resolve mixing throughout the tail. We find very little difference in the total amount of gas removed from the unmagnetized and magnetized galaxies, although a magnetic field with a radial component will initially accelerate stripped gas more quickly. In general, we find that magnetic fields in the disk lead to slower velocities in the stripped gas near the disk and faster velocities farther from the disk. We also find that magnetic fields in the galactic gas lead to larger unmixed structures in the tail. Finally, we discuss whether ram pressure stripped tails can magnetize the ICM. We find that the total magnetic energy density grows as the tail lengthens, likely through turbulence. There are μG-strength fields in the tail in all of our MHD runs, which survive to at least 100 kpc from the disk (the edge of our simulated region), indicating that the area-filling factor of magnetized tails in a cluster could be large.

TGM5 mutations impact epidermal differentiation in acral peeling skin syndrome.

Science.gov (United States)

Pigors, Manuela; Kiritsi, Dimitra; Cobzaru, Cristina; Schwieger-Briel, Agnes; Suárez, Jose; Faletra, Flavio; Aho, Heikki; Mäkelä, Leeni; Kern, Johannes S; Bruckner-Tuderman, Leena; Has, Cristina

2012-10-01

Acral peeling skin syndrome (APSS) is an autosomal recessive skin disorder characterized by acral blistering and peeling of the outermost layers of the epidermis. It is caused by mutations in the gene for transglutaminase 5, TGM5. Here, we report on clinical and molecular findings in 11 patients and extend the TGM5 mutation database by four, to our knowledge, previously unreported mutations: p.M1T, p.L41P, p.L214CfsX15, and p.S604IfsX9. The recurrent mutation p.G113C was found in 9 patients, but also in 3 of 100 control individuals in a heterozygous state, indicating that APSS might be more widespread than hitherto expected. Using quantitative real-time PCR, immunoblotting, and immunofluorescence analysis, we demonstrate that expression and distribution of several epidermal differentiation markers and corneodesmosin (CDSN) is altered in APSS keratinocytes and skin. Although the expression of transglutaminases 1 and 3 was not changed, we found an upregulation of keratin 1, keratin 10, involucrin, loricrin, and CDSN, probably as compensatory mechanisms for stabilization of the epidermal barrier. Our results give insights into the consequences of TGM5 mutations on terminal epidermal differentiation.

Autodegradation of 125I-labeled human epidermal cell surface proteins

International Nuclear Information System (INIS)

Hashimoto, K.; Singer, K.H.; Lazarus, G.S.

1982-01-01

Triton X-100 extracts of cultured human epidermal cells exhibited proteolytic activity as measured by the hydrolysis of [ 3 H]-casein at neutral pH. The majority of endogenous proteolytic activity was inhibited by parahydroxy mercuribenzoate and by mersalyl acid, indicating the enzyme(s) was a thiol class proteinase(s). Crude Triton X-100 extracts were prepared from epidermal cells following labeling of proteins with 125 I. Autodegradation of labeled proteins at 37 degrees C was detected as early as 1 hr and reached a plateau level by 4 hr. Degradation was inhibited by thiol class proteinase inhibitors. Among the detergent-solubilized radiolabeled proteins a polypeptide chain of Mr 155,000 was particularly sensitive to degradation by endogenous thiol proteinase(s)

Precise ion optical description of strip-line pulsed magnetic lenses

International Nuclear Information System (INIS)

Varentsov, D.; Spiller, P.; Eickhoff, H.; Hoffmann, D.H.H.

2002-01-01

A specific computer code has been developed to investigate ion optical properties of a new generation of pulsed strip-line high current magnets. The code is based on a modern 'Differential Algebra' computational technique and it is able to calculate transfer matrices of pulsed strip-line magnets up to arbitrary order. The realistic three-dimensional distribution of the magnetic field in pulsed lenses as well as all the fringing field effects are taken into account in the simulations. We have demonstrated, that for precise description of such magnets one cannot use the existing ion optical codes where ideal multipole field distributions and fringing fields, typical for conventional iron-dominated magnets are assumed. The transfer matrix elements of pulsed strip-line lenses differ significantly from those of conventional magnets, especially in higher orders

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

DEFF Research Database (Denmark)

Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure

2003-01-01

alpha 7 nicotinic acetylcholine receptors that are present in keratinocytes. These results identify SLURP-1 as a secreted epidermal neuromodulator which is likely to be essential for both epidermal homeostasis and inhibition of TNF-alpha release by macrophages during wound healing. This explains both...

Mobile Image Ratiometry: A New Method for Instantaneous Analysis of Rapid Test Strips

OpenAIRE

Donald C. Cooper; Bryan Callahan; Phil Callahan; Lee Burnett

2012-01-01

Here we describe Mobile Image Ratiometry (MIR), a new method for the automated quantification of standardized rapid immunoassay strips using consumer-based mobile smartphone and tablet cameras. To demonstrate MIR we developed a standardized method using rapid immunotest strips directed against cocaine (COC) and its major metabolite, benzoylecgonine (BE). We performed image analysis of three brands of commercially available dye-conjugated anti-COC/BE antibody test strips in response to three d...

Nuclear fuel element containing strips of an alloyed Zr, Ti, and Ni getter material

International Nuclear Information System (INIS)

Grossman, L.N.; Packard, D.R.

1975-01-01

A nuclear fuel element for use in the core of a nuclear reactor is disclosed. The nuclear fuel element has disposed therein an alloy having the essential components of nickel, titanium and zirconium, and the alloy reacts with water, water vapor and reactive gases at reactor ambient temperatures. The alloy is disposed in the plenum of the fuel element in the form of strips and preferably the strips are positioned inside a helical member in the plenum. The position of the alloy strips permits gases and liquids entering the plenum to contact and react with the alloy strips. (U.S.)

78 FR 77649 - Polyethylene Terephthalate Film, Sheet, and Strip From the United Arab Emirates; Preliminary...

Science.gov (United States)

2013-12-24

... Film, Sheet, and Strip From the United Arab Emirates; Preliminary Results of Antidumping Duty... film, sheet, and strip (PET Film) from the United Arab Emirates (UAE). The period of review (POR) is... Administrative Review: Polyethylene Terephthalate Film, Sheet, and Strip from the United Arab Emirates...

GAS LOSS BY RAM PRESSURE STRIPPING AND INTERNAL FEEDBACK FROM LOW-MASS MILKY WAY SATELLITES

Energy Technology Data Exchange (ETDEWEB)

Emerick, Andrew; Low, Mordecai-Mark Mac [Department of Astronomy, Columbia University, New York, NY (United States); Grcevich, Jana [Department of Astrophysics, American Museum of Natural History, New York, NY (United States); Gatto, Andrea [Max-Planck-Institute für Astrophysik, Garching, bei München (Germany)

2016-08-01

The evolution of dwarf satellites in the Milky Way (MW) is affected by a combination of ram pressure stripping (RPS), tidal stripping, and internal feedback from massive stars. We investigate gas loss processes in the smallest satellites of the MW using three-dimensional, high-resolution, idealized wind tunnel simulations, accounting for gas loss through both ram pressure stripping and expulsion by supernova feedback. Using initial conditions appropriate for a dwarf galaxy like Leo T, we investigate whether or not environmental gas stripping and internal feedback can quench these low-mass galaxies on the expected timescales, shorter than 2 Gyr. We find that supernova feedback contributes negligibly to the stripping rate for these low star formation rate galaxies. However, we also find that RPS is less efficient than expected in the stripping scenarios we consider. Our work suggests that although RPS can eventually completely strip these galaxies, other physics is likely at play to reconcile our computed stripping times with the rapid quenching timescales deduced from observations of low-mass MW dwarf galaxies. We discuss the roles additional physics may play in this scenario, including host-satellite tidal interactions, cored versus cuspy dark matter profiles, reionization, and satellite preprocessing. We conclude that a proper accounting of these physics together is necessary to understand the quenching of low-mass MW satellites.

Ultrathin epidermal strain sensor based on an elastomer nanosheet with an inkjet-printed conductive polymer

Science.gov (United States)

Tetsu, Yuma; Yamagishi, Kento; Kato, Akira; Matsumoto, Yuya; Tsukune, Mariko; Kobayashi, Yo; Fujie, Masakatsu G.; Takeoka, Shinji; Fujie, Toshinori

2017-08-01

To minimize the interference that skin-contact strain sensors cause natural skin deformation, physical conformability to the epidermal structure is critical. Here, we developed an ultrathin strain sensor made from poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) inkjet-printed on a polystyrene-polybutadiene-polystyrene (SBS) nanosheet. The sensor, whose total thickness and gauge factor were ˜1 µm and 0.73 ± 0.10, respectively, deeply conformed to the epidermal structure and successfully detected the small skin strain (˜2%) while interfering minimally with the natural deformation of the skin. Such an epidermal strain sensor will open a new avenue for precisely detecting the motion of human skin and artificial soft-robotic skin.

Pigmented epidermal cyst with dense collection of melanin: A rare entity - Report of a case with review of the literature.

Science.gov (United States)

Jayalakshmy, P S; Subitha, K; Priya, P V; Johnson, Gerald

2012-05-01

Epidermal cyst is a very common benign cystic lesion of the skin. It is usual to find ulceration of the lining epithelium, rupture of the cyst wall with chronic inflammation and foreign body giant cell reaction. But, it is very rare to see an epidermal cyst with marked accumulation of melanin pigment. Only a few cases of pigmented epidermal cyst with dense collection of melanin pigment have been published in the literature. Here, we are reporting a case of ruptured epidermal cyst with keratin granuloma formation and showing dense collection of melanin pigment.

Young tourists visiting strip clubs and paying for sex

DEFF Research Database (Denmark)

Hesse, Morten; Tutenges, Sébastien

2011-01-01

Little is known about young adults’ use of strip clubs and prostitution during their holidays abroad. This study examined this issue with a sample of 1125 Danish tourists between the ages of 16 and 34, and sought data about the frequency with which they paid for sex and attended strip clubs while...... with non-use of condoms with one or more sexual partners. The results of this study can be interpreted as part of a wider culture of commodified debauchery, which predominates many nightlife resorts....

A plane mirror experiment inspired by a comic strip

Science.gov (United States)

Lúcio Prados Ribeiro, Jair

2016-01-01

A comic strip about a plane mirror was used in a high school optics test, and it was perceived that a large portion of the students believed that the mirror should be larger than the object so the virtual image could be entirely visible. Inspired on the comic strip, an experimental demonstration with flat mirrors was developed, in order to readdress this topic learning. Students were encouraged to create their own investigation of the phenomenon with a simple instrumental apparatus and also suggest different experimental approaches.

Energy resolution in X-ray detecting micro-strip gas counters

CERN Document Server

Bateman, J E; Derbyshire, G E; Duxbury, D M; Mir, J A; Spill, E J; Stephenson, R

2002-01-01

Systematic measurements of the energy resolution available from a Micro-Strip Gas Counter (MSGC) are presented. The effect of factors such as bias potential, gas filling and strip geometry on the energy resolution are examined in detail and related to a simple model. The geometry of the MSGC is adapted to permit 'wall-less' detection of X-rays and this results in useful improvements in the pulse height spectra.

Stripping study of U(VI) from loaded TBP/n-paraffin using ammonium nitrate bearing waste as strippant

International Nuclear Information System (INIS)

Shrishma Paik; Biswas, S.; Bhattacharya, S.; Roy, S.B.

2013-01-01

Stripping studies of U(VI) from loaded solvent TBP/n-paraffin was carried out using ammonium nitrate solution as strippant. Effects of various stripping parameters such as concentration of ammonium nitrate solution, U(VI) concentration in organic phase, initial pH of strippant, temperature etc. have been investigated in detail. Kinetics of the stripping process by ammonium nitrate was found to be slower than that of stripping with water. It was observed that with the increase in ammonium nitrate concentration in aqueous solution, stripping of U(VI) decreased. With the increase in U(VI) loading in the organic phase, there was an increase in uranium stripping for ammonium nitrate whereas for distilled water it becomes reverse. With the increase in pH of the aqueous ammonium nitrate solution, stripping increased up to a certain pH of 8.5 and after that precipitation of uranium started. Increase in temperature of the biphasic system shows an enhancing effect of U(VI) stripping. Evaluation of thermodynamic data such as ΔH indicated that the process is endothermic. Based on the optimized conditions, McCabe-Thiele diagram was constructed for U(VI) stripping using ammonium nitrate solution at room temperature. (author)

Ram Pressure Stripping Made Easy: An Analytical Approach

Science.gov (United States)

Köppen, J.; Jáchym, P.; Taylor, R.; Palouš, J.

2018-06-01

The removal of gas by ram pressure stripping of galaxies is treated by a purely kinematic description. The solution has two asymptotic limits: if the duration of the ram pressure pulse exceeds the period of vertical oscillations perpendicular to the galactic plane, the commonly used quasi-static criterion of Gunn & Gott is obtained which uses the maximum ram pressure that the galaxy has experienced along its orbit. For shorter pulses the outcome depends on the time-integrated ram pressure. This parameter pair fully describes the gas mass fraction that is stripped from a given galaxy. This approach closely reproduces results from SPH simulations. We show that typical galaxies follow a very tight relation in this parameter space corresponding to a pressure pulse length of about 300 Myr. Thus, the Gunn & Gott criterion provides a good description for galaxies in larger clusters. Applying the analytic description to a sample of 232 Virgo galaxies from the GoldMine database, we show that the ICM provides indeed the ram pressures needed to explain the deficiencies. We also can distinguish current and past strippers, including objects whose stripping state was unknown.

Multistep change in epidermal growth factor receptors during spontaneous neoplastic progression in Chinese hamster embryo fibroblasts

International Nuclear Information System (INIS)

Wakshull, E.; Kraemer, P.M.; Wharton, W.

1985-01-01

Whole Chinese hamster embryo lineages have been shown to undergo multistep spontaneous neoplastic progression during serial passage in culture. The authors have studied the binding, internalization, and degradation of 125 I-labeled epidermal growth factor at four different stages of transformation. The whole Chinese hamster embryo cells lost cell surface epidermal growth factor receptors gradually during the course of neoplastic progression until only 10% of the receptor number present in the early-passage cells (precrisis) were retained in the late-passage cells (tumorigenic). No differences in internalization rates, chloroquine sensitivity, or ability to degrade hormone between the various passage levels were seen. No evidence for the presence in conditioned medium of transforming growth factors which might mask or down-regulate epidermal growth factor receptor was obtained. These results suggest that a reduction in cell surface epidermal growth factor receptor might be an early event during spontaneous transformation in whole Chinese hamster embryo cells

Multiple Electron Stripping of Heavy Ion Beams

International Nuclear Information System (INIS)

Mueller, D.; Grisham, L.; Kaganovich, I.; Watson, R. L.; Horvat, V.; Zaharakis, K. E.; Peng, Y.

2002-01-01

One approach being explored as a route to practical fusion energy uses heavy ion beams focused on an indirect drive target. Such beams will lose electrons while passing through background gas in the target chamber, and therefore it is necessary to assess the rate at which the charge state of the incident beam evolves on the way to the target. Accelerators designed primarily for nuclear physics or high energy physics experiments utilize ion sources that generate highly stripped ions in order to achieve high energies economically. As a result, accelerators capable of producing heavy ion beams of 10 to 40 Mev/amu with charge state 1 currently do not exist. Hence, the stripping cross-sections used to model the performance of heavy ion fusion driver beams have, up to now, been based upon theoretical calculations. We have investigated experimentally the stripping of 3.4 Mev/amu Kr 7+ and Xe +11 in N2; 10.2 MeV/amu Ar +6 in He, N2, Ar and Xe; 19 MeV/amu Ar +8 in He, N2, Ar and Xe; 30 MeV He 1 + in He, N2, Ar and Xe; and 38 MeV/amu N +6 in He, N2, Ar and Xe. The results of these measurements are compared with the theoretical calculations to assess their applicability over a wide range of parameters

Scaffolding proteins in the development and maintenance of the epidermal permeability barrier.

Science.gov (United States)

Crawford, Melissa; Dagnino, Lina

2017-10-02

The skin of mammals and other terrestrial vertebrates protects the organism against the external environment, preventing heat, water and electrolyte loss, as well as entry of chemicals and pathogens. Impairments in the epidermal permeability barrier function are associated with the genesis and/or progression of a variety of pathological conditions, including genetic inflammatory diseases, microbial and viral infections, and photodamage induced by UV radiation. In mammals, the outside-in epidermal permeability barrier is provided by the joint action of the outermost cornified layer, together with assembled tight junctions in granular keratinocytes found in the layers underneath. Tight junctions serve as both outside-in and inside-out barriers, and impede paracellular movements of ions, water, macromolecules and microorganisms. At the molecular level, tight junctions consist of integral membrane proteins that form an extracellular seal between adjacent cells, and associate with cytoplasmic scaffold proteins that serve as links with the actin cytoskeleton. In this review, we address the roles that scaffold proteins play specifically in the establishment and maintenance of the epidermal permeability barrier, and how various pathologies alter or impair their functions.

The stripping foil test stand in the Linac4 transfer line

CERN Document Server

Weterings, W; Noulibos, R; Sillanoli, Y; van Trappen, P

2015-01-01

The 160 MeV H− beam from the Linac4 (L4) linear accelerator at CERN will be injected into the proton synchrotron booster (PSB) with a new H− charge-exchange injection system. It will include a stripping foil, to convert H− into protons by stripping off the electrons. To gain experience with these very fragile foils, prior to the installation in the PSB, and test different foil materials and thicknesses, lifetimes of the foils, the foil changing mechanism and interlocking functions, a stripping foil test stand will be installed in the L4 transfer line in 2015. This paper describes the mechanical design of the system and discusses the test possibilities and parameters.

The stripping foil test stand in the Linac4 transfer line

International Nuclear Information System (INIS)

Weterings, W.; Bracco, C.; Noulibos, R.; Sillanoli, Y.; Trappen van, P.

2015-01-01

The 160 MeV H - beam from the Linac4 (L4) linear accelerator at CERN will be injected into the proton synchrotron booster (PSB) with a new H - charge-exchange injection system. It will include a stripping foil, to convert H - into protons by stripping off the electrons. To gain experience with these very fragile foils, prior to the installation in the PSB, and test different foil materials and thicknesses, lifetimes of the foils, the foil changing mechanism and interlocking functions, a stripping foil test stand will be installed in the L4 transfer line in 2015. This paper describes the mechanical design of the system and discusses the test possibilities and parameters. (author)

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

Directory of Open Access Journals (Sweden)

Yira Bermudez

Full Text Available Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and GPR109B that signal through G(i-mediated inhibition of adenylyl cyclase. We have examined the expression, cellular distribution, and functionality of GPR109A/B in human skin and skin derived epidermal cells.Nicotinic acid increases epidermal differentiation in photodamaged human skin as judged by the terminal differentiation markers caspase 14 and filaggrin. Both GPR109A and GPR109B genes are transcribed in human skin and in epidermal keratinocytes, but expression in dermal fibroblasts is below limits of detection. Receptor transcripts are greatly over-expressed in squamous cell cancers. Receptor protein in normal skin is prominent from the basal through granular layers of the epidermis, with cellular localization more dispersive in the basal layer but predominantly localized at the plasma membrane in more differentiated epidermal layers. In normal human primary and immortalized keratinocytes, nicotinic acid receptors show plasma membrane localization and functional G(i-mediated signaling. In contrast, in a squamous cell carcinoma derived cell line, receptor protein shows a more diffuse cellular localization and the receptors are nearly non-functional.The results of these studies justify future genetic and pharmacological intervention studies to define possible specific role(s of nicotinic acid receptors in human skin homeostasis.

Elastic crack-tip stress field in a semi-strip

Directory of Open Access Journals (Sweden)

Victor Reut

2018-04-01

Full Text Available In this article the plain elasticity problem for a semi-strip with a transverse crack is investigated in the different cases of the boundary conditions at the semi-strips end. Unlike many works dedicated to this subject, the fixed singularities in the singular integral equation�s kernel are considered. The integral transformations� method is applied by the generalized scheme to reduce the initial problem to a one-dimensional problem. The one-dimensional problem is formulated as the vector boundary value problem which is solved with the help of matrix differential calculations and Green�s matrix apparatus. The solution of the problem is reduced to the solving of the system of three singular integral equations. Depending on the conditions given on the short edge of the semi-strip, the constructed singular integral equation can have one, or two fixed singularities. A special method is applied to solve this equation in regard of the singularities existence. Hence the system of the singular integral equations (SSIE is solved with the help of the generalized method. The stress intensity factors (SIF are investigated for different lengths of crack. The novelty of this work is in the application of new approach allowing the consideration of the fixed singularities in the problem about a transverse crack in the elastic semi-strip. The comparison of the numerical results� accuracy during the usage of the different approaches to the solving of SSIE is worked out

Development of a Calibration Strip for Immunochromatographic Assay Detection Systems.

Science.gov (United States)

Gao, Yue-Ming; Wei, Jian-Chong; Mak, Peng-Un; Vai, Mang-I; Du, Min; Pun, Sio-Hang

2016-06-29

With many benefits and applications, immunochromatographic (ICG) assay detection systems have been reported on a great deal. However, the existing research mainly focuses on increasing the dynamic detection range or application fields. Calibration of the detection system, which has a great influence on the detection accuracy, has not been addressed properly. In this context, this work develops a calibration strip for ICG assay photoelectric detection systems. An image of the test strip is captured by an image acquisition device, followed by performing a fuzzy c-means (FCM) clustering algorithm and maximin-distance algorithm for image segmentation. Additionally, experiments are conducted to find the best characteristic quantity. By analyzing the linear coefficient, an average value of hue (H) at 14 min is chosen as the characteristic quantity and the empirical formula between H and optical density (OD) value is established. Therefore, H, saturation (S), and value (V) are calculated by a number of selected OD values. Then, H, S, and V values are transferred to the RGB color space and a high-resolution printer is used to print the strip images on cellulose nitrate membranes. Finally, verification of the printed calibration strips is conducted by analyzing the linear correlation between OD and the spectral reflectance, which shows a good linear correlation (R² = 98.78%).

Low material budget floating strip Micromegas for ion transmission radiography

Energy Technology Data Exchange (ETDEWEB)

Bortfeldt, J., E-mail: jonathan.bortfeldt@cern.ch [LMU Munich, LS Schaile, Am Coulombwall 1, D-85748 Garching (Germany); Biebel, O.; Flierl, B.; Hertenberger, R.; Klitzner, F.; Lösel, Ph. [LMU Munich, LS Schaile, Am Coulombwall 1, D-85748 Garching (Germany); Magallanes, L. [LMU Munich, LS Parodi, Am Coulombwall 1, D-85748 Garching (Germany); University Hospital Heidelberg, Im Neuenheimer Feld 672, D-69120 Heidelberg (Germany); Müller, R. [LMU Munich, LS Schaile, Am Coulombwall 1, D-85748 Garching (Germany); Parodi, K. [LMU Munich, LS Parodi, Am Coulombwall 1, D-85748 Garching (Germany); Heidelberg Ion-Beam Therapy Center, Im Neuenheimer Feld 450, D-69120 Heidelberg (Germany); Schlüter, T. [LMU Munich, Excellence Cluster Universe, Boltzmannstr. 2, D-85748 Garching (Germany); Voss, B. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstr. 1, D-64291 Darmstadt (Germany); Zibell, A. [JMU Würzburg, Sanderring 2, D-97070 Würzburg (Germany)

2017-02-11

Floating strip Micromegas are high-accuracy and discharge insensitive gaseous detectors, able to track single particles at fluxes of 7 MHz/cm{sup 2} with 100 μm resolution. We developed low-material-budget detectors with one-dimensional strip readout, suitable for tracking at highest particle rates as encountered in medical ion transmission radiography or inner tracker applications. Recently we additionally developed Kapton-based floating strip Micromegas with two-dimensional strip readout, featuring an overall thickness of 0.011 X{sub 0}. These detectors were tested in high-rate proton and carbon-ion beams at the tandem accelerator in Garching and the Heidelberg Ion-Beam Therapy Center, operated with an optimized Ne:CF{sub 4} gas mixture. By coupling the Micromegas detectors to a new scintillator based range detector, ion transmission radiographies of PMMA and tissue-equivalent phantoms were acquired. The range detector with 18 layers is read out via wavelength shifting fibers, coupled to a multi-anode photomultiplier. We present the performance of the Micromegas detectors with respect to timing and single plane track reconstruction using the μTPC method. We discuss the range resolution of the scintillator range telescope and present the image reconstruction capabilities of the combined system.

Radiologic Findings of Epidermal Cysts in the Trunk

International Nuclear Information System (INIS)

Kim, Myung Hyun; Chung, Jae Joon; Park, Kyoung Seuk; Park, Su Mi

2005-01-01

To evaluate the ultrasonographic (US) or computer tomography (CT) findings of surgically proven epidermal cysts in the trunk, and to compare the echogenicity of cysts with internal contents. Forty-five patients were retrospectively evaluated. US and CT findings of epidermal cysts were assessed in regard to location, size, shape, number, echogenicity, posterior sound enhancement, internal density, septa, mural nodule and calcification, perilesional infiltration, contrast enhancement, and internal contents. All 45 patients (M:F=29:16; US in 26, CT in 19) had only one cyst, and they were located in the buttocks (n=19), back (n=13), inguinal (n=4), posterior neck (n=3), perineum (n=2), abdominal wall (n=2), presternal (n=1), and axilla (n=1). Of 26 patients who underwent US, there were 8 cases of homogeneously hypoechoic mass (30.8%), 8 of inhomogeneously hypoechoic mass (30.8%), 7 of homogeneously hypoechoic mass with internal hypoechoic lines and echogenic spots (26.9%) and 3 of homogeneously hypoechoic mass with internal echogenic spots (11.5%). Posterior sound enhancement was noted in 21 patients (80.8%). Of 19 patients who underwent CT, there were 14 cases of simple cyst (73.7%) and 5 of abscess-like lesion (26.3%). Overlying skin thickening (n=13), contrast enhancement of cystic wall (n=11), perilesional infiltration (n=7), and internal septa (n=6) were demonstrated. The internal contents of the cysts were keratinous (n=27, 60.0%) or greasy (n=15, 33.3%) material. There was no statistical significance between the echogenicity of the cysts and the internal contents (p > 0.2). Epidermal cysts showed homogeneous or inhomogeneous hypoechoic mass with posterior sound enhancement on US. There was no relationship between the echogenicity of the cysts and the internal contents. In the case of ruptured cyst, an abscess-like lesion with wall enhancement and perilesional infiltration was noted on CT scan

Properties of a six-gap timing resistive plate chamber with strip readout

International Nuclear Information System (INIS)

Ammosov, V.V.; Gapienko, V.A.; Semak, A.A.; Sviridov, Yu.M.; Zaets, V.G.; Gavrishchuk, O.P.; Kuz'min, N.A.; Sychkov, S.Ya.; Usenko, E.A.; Yukaev, A.I.

2009-01-01

Six-gap glass timing resistive plate chamber with strip readout was tested using IHEP U-70 PS test beam. The time resolution of ∼ 45 ps at efficiency larger than 98% was achieved. Position resolution along strip was estimated to be ∼1 cm

Exudative epidermitis in pigs caused by toxigenic Staphylococcus chromogenes.

Science.gov (United States)

Andresen, Lars Ole; Ahrens, Peter; Daugaard, Lise; Bille-Hansen, Vivi

2005-02-25

Staphylococcus chromogenes is closely related to Staphylococcus hyicus, which is recognised as the causative agent of exudative epidermitis (EE) in pigs. S. chromogenes is part of the normal skin flora of pigs, cattle and poultry and has so far been considered non-pathogenic to pigs. A strain of S. chromogenes producing exfoliative toxin type B, ExhB, was identified by the use of a multiplex PCR specific for the exfoliative toxins from S. hyicus. The exfoliative toxin from S. chromogenes reacted in immunoblot analysis with polyclonal and monoclonal antibodies specific to ExhB from S. hyicus and had an apparent molecular weight of 30 kDa. Sequencing the gene encoding the exfoliative toxin from S. chromogenes revealed that the molecular weight of the toxin with the signal peptide and the mature toxin was 30,553 and 26,694 Da, respectively. Comparison of the exhB genes from S. chromogenes strain VA654 and S. hyicus strain 1289D-88 showed differences in seven base pairs of the DNA sequences and in two amino acid residues in the deduced amino acid sequences. Pigs were experimentally inoculated with S. chromogenes strain VA654. By clinical observations and histopathological evaluation of the skin alterations, all pigs revealed development of generalized exudative epidermitis. No toxin producing S. hyicus was isolated from the pigs and all ExhB-positive bacterial isolates were identified as S. chromogenes. This confirmed that the disease-causing agent was the inoculated S. chromogenes strain VA654. The results of this study show that S. chromogenes may cause exudative epidermitis in pigs.

Simulation of accelerated strip cooling on the hot rolling mill run-out roller table

Directory of Open Access Journals (Sweden)

E.Makarov

2016-07-01

Full Text Available A mathematical model of the thermal state of the metal in the run-out roller table continuous wide hot strip mill. The mathematical model takes into account heat generation due to the polymorphic γ → α transformation of supercooled austenite phase state and the influence of the chemical composition of the steel on the physical properties of the metal. The model allows calculation of modes of accelerated cooling strips on run-out roller table continuous wide hot strip mill. Winding temperature calculation error does not exceed 20°C for 98.5 % of strips of low-carbon and low-alloy steels

Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus

Directory of Open Access Journals (Sweden)

Naser Tayyebi Meibodi

2011-01-01

Full Text Available Epidermolytic hyperkeratosis presents with perinuclear vacuolization of the keratinocytes in spinous and granular layers, keratinocytes with ill-defined limits, which leads to a reticulate appearance of the epidermis, an increased number of variously shaped and sized basophilic keratohyalin granules and the same sized eosinophilic trichohyalin granules, at any level of epidermis, mainly in the stratum granulosum, and compact hyperkeratosis. This minor reactive pathologic reaction pattern of skin is found in large variety of diseases. This paper is the first case report of such pattern in inflammatory linear verrucous epidermal nevus. Our case is of a 23-year-old man with pruritic verrucous lesions of trunk and extremities initiated since 13 years ago. Physical examination revealed white linear hyperkeratotic lesions, some of them on erythematous background and also classic epidermal nevus. No skeletal, ophthalmic, and nervous system involvement was detected. Microscopic study of pruritic verrucous lesions showed psoriasiform acanthosis, mild papillomatous, hyperkeratosis, and epidermolytic hyperkeratotic changes in hair follicles and acrosyrinx accompanied with moderate perivascular inflammation.

Growth of melanocytes in human epidermal cell cultures

International Nuclear Information System (INIS)

Staiano-Coico, L.; Hefton, J.M.; Amadeo, C.; Pagan-Charry, I.; Madden, M.R.; Cardon-Cardo, C.

1990-01-01

Epidermal cell cultures were grown in keratinocyte-conditioned medium for use as burn wound grafts; the melanocyte composition of the grafts was studied under a variety of conditions. Melanocytes were identified by immunohistochemistry based on a monoclonal antibody (MEL-5) that has previously been shown to react specifically with melanocytes. During the first 7 days of growth in primary culture, the total number of melanocytes in the epidermal cultures decreased to 10% of the number present in normal skin. Beginning on day 2 of culture, bipolar melanocytes were present at a mean cell density of 116 +/- 2/mm2; the keratinocyte to melanocyte ratio was preserved during further primary culture and through three subpassages. Moreover, exposure of cultures to mild UVB irradiation stimulated the melanocytes to proliferate, suggesting that the melanocytes growing in culture maintained their responsiveness to external stimuli. When the sheets of cultured cells were enzymatically detached from the plastic culture flasks before grafting, melanocytes remained in the basal layer of cells as part of the graft applied to the patient

Studies on the application of silicon strip counters in the ELAN experiment

International Nuclear Information System (INIS)

Listl, R.

1989-02-01

In this thesis it had to be shown whether it is possible to perform at the external electron beam at ELSA with its high background particle identification and track reconstruction with a strip counter. In order to have an as good as possible separation between true and false events a coincidence apparture was constructed. Because the signals which the strip counter yields are very small, it had to be provided that all disturbing signals are suppressed. The evaluation shows that by means of the taken measures coincident events can be well separated from background events. In 60% of all events a unique assignment of the event to only one strip is possible. The random rate can be reduced by additional detectors and the by this possible track reconstruction. By improvement of the duty cycle here a further improvement should arise. It is thus possible to perform with a silicon strip counter measurements at the ELAN experiment. By this the possibility results to improve the start-position resolution, the start-angle measurement, and the momentum reconstruction by this, that now a point (track) near to the target can be obtained. If the strip counter is added to the trigger one has a quite strong suppression of the background. (orig./HSI) [de

Flat Plate Boundary Layer Stimulation Using Trip Wires and Hama Strips

Science.gov (United States)

Peguero, Charles; Henoch, Charles; Hrubes, James; Fredette, Albert; Roberts, Raymond; Huyer, Stephen

2017-11-01

Water tunnel experiments on a flat plate at zero angle of attack were performed to investigate the effect of single roughness elements, i.e., trip wires and Hama strips, on the transition to turbulence. Boundary layer trips are traditionally used in scale model testing to force a boundary layer to transition from laminar to turbulent flow at a single location to aid in scaling of flow characteristics. Several investigations of trip wire effects exist in the literature, but there is a dearth of information regarding the influence of Hama strips on the flat plate boundary layer. The intent of this investigation is to better understand the effects of boundary layer trips, particularly Hama strips, and to investigate the pressure-induced drag of both styles of boundary layer trips. Untripped and tripped boundary layers along a flat plate at a range of flow speeds were characterized with multiple diagnostic measurements in the NUWC/Newport 12-inch water tunnel. A wide range of Hama strip and wire trip thicknesses were used. Measurements included dye flow visualization, direct skin friction and parasitic drag force, boundary layer profiles using LDV, wall shear stress fluctuations using hot film anemometry, and streamwise pressure gradients. Test results will be compared to the CFD and boundary layer model results as well as the existing body of work. Conclusions, resulting in guidance for application of Hama strips in model scale experiments and non-dimensional predictions of pressure drag will be presented.

Strip Tillage and Early-Season Broadleaf Weed Control in Seeded Onion (Allium cepa

Directory of Open Access Journals (Sweden)

Sarah Gegner-Kazmierczak

2016-03-01

Full Text Available Field experiments were conducted in 2007 and 2008 near Oakes, North Dakota (ND, USA, to evaluate if strip tillage could be incorporated into a production system of seeded onion (Allium cepa to eliminate the standard use of a barley (Hordeum vulgare companion crop with conventional, full width tillage, yet support common early-season weed control programs. A split-factor design was used with tillage (conventional and strip tillage as the main plot and herbicide treatments (bromoxynil, DCPA, oxyfluorfen, and pendimethalin as sub-plots. Neither tillage nor herbicide treatments affected onion stand counts. Common lambsquarters (Chenopodium album densities were lower in strip tillage compared to conventional tillage up to three weeks after the post-emergence applied herbicides. In general, micro-rate post-emergence herbicide treatments provided greater early-season broadleaf weed control than pre-emergence herbicide treatments. Onion yield and grade did not differ among herbicide treatments because the mid-season herbicide application provided sufficient control/suppression of the early-season weed escapes that these initial weed escapes did not impact onion yield or bulb diameter. In 2007, onion in the strip tillage treatment were larger in diameter resulting in greater total and marketable yields compared to conventional tillage. Marketable onion yield was 82.1 Mg ha−1 in strip tillage and 64.9 Mg ha−1 in conventional tillage. Results indicate that strip tillage use in direct-seeded onion production was beneficial, especially when growing conditions were conducive to higher yields and that the use of strip tillage in onion may provide an alternative to using a companion crop as it did not interfere with either early-season weed management system.

Irradiation of protoporphyric mice induces down-regulation of epidermal eicosanoid metabolism

International Nuclear Information System (INIS)

He, D.; Lim, H.W.

1991-01-01

This study investigated the effect of radiation on clinical and histologic changes, and on cutaneous eicosanoid metabolism, in Skh:HR-1 hairless albino mice rendered protoporphyric by the administration of collidine. At 0.1-18 h after exposure to 12 kJ/m2 of 396-406 nm irradiation, thicknesses of back skin and ears were measured, and histologic changes were evaluated by using hematoxylin and eosin (H-E) and Giemsa's stains. Activities of eicosanoid-metabolizing enzymes in epidermal and dermal homogenates were assessed by incubating the tissue homogenates with 3H-AA, followed by quantitation of the eicosanoids generated by radio-TLC. In irradiated protoporphyric mice, an increase of back-skin thickness was noted at 0.1 h, reaching a peak at 18 h, whereas maximal increase in ear thickness was observed at 12 h. Histologic changes included dermal edema, increased mast cell degranulation, and mononuclear cells in the dermis. In these irradiated protoporphyric animals, generations of 6 keto-PGF1a, PGF2a, PGE2, PGD2, and HETE by epidermal eicosanoid-metabolizing enzymes were markedly suppressed at all the timepoints studied. Dermal eicosanoid-metabolizing enzymes of irradiated protoporphyric mice generated increased amounts of PGE2 and HETE at 18 h, probably reflecting the presence of dermal cellular infiltrates. The suppression of the activities of epidermal eicosanoid-metabolizing enzymes was prevented by intraperitoneal injection of WR-2721, a sulfhydryl group generator, prior to irradiation, suggesting that the suppression was secondary to photo-oxidative damage of the enzymes during the in vivo phototoxic response. These results suggest that the effect of protoporphyrin and radiation on cutaneous eicosanoid metabolism in this animal model in vivo is that of a down regulation of the activities of epidermal eicosanoid-metabolizing enzymes

Microstructure, texture and magnetic properties of strip-cast 1.3% Si non-oriented electrical steels

Energy Technology Data Exchange (ETDEWEB)

Zhang Yuanxiang, E-mail: yunboxu@126.com [State Key Laboratory of Rolling Technology and Automation, Northeastern University, Shenyang (China); Xu Yunbo; Liu Haitao; Li Chenggang; Cao Guangming; Liu Zhenyu; Wang Guodong [State Key Laboratory of Rolling Technology and Automation, Northeastern University, Shenyang (China)

2012-10-15

In this work, the evolution of microstructure, texture and magnetic properties of non-oriented 1.3% silicon steel processed using the twin-roll strip casting was investigated, especially under different solidification structures. A number of microstructures about the as-cast strips show that the initial solidification structure of casting a strip can be controlled by the melt superheats. The microstructures with the average grain size of {approx}100-400 {mu}m can be obtained in strips when the melt superheats are from 20 to 60 Degree-Sign C. A nearly random, diffuse, homogeneous texture under a low melt superheat, but comparatively developed {l_brace}100{r_brace} oriented grains are formed under a high melt superheat through the cast strip thickness. The relatively low core loss and high magnetic induction can be obtained in the cold rolled and annealed sheets when increasing the initial grain size of cast-strip. The textures in annealed sheets with coarse initial grain size are characterized by the relatively strong Goss component and {l_brace}001{r_brace} fiber but weak {gamma}-fiber component, which lead to the high permeability. - Highlights: Black-Right-Pointing-Pointer The superheat has an evident effect on the grain size and orientation of strip. Black-Right-Pointing-Pointer Developed Cube and Goss textures were formed in the annealed sheet. Black-Right-Pointing-Pointer High magnetic properties were obtained in the twin-rolled strip casting process.

Cylindrical articles surfacing with a strip electrode at an angle to the generatrix

Directory of Open Access Journals (Sweden)

Віталій Петрович Іванов

2017-07-01

Full Text Available The use of the strip electrode when surfacing is made along a variable path leads to a change in the melting process and the formation of a weld bead, due to the absence, in contrast to the wire electrode, of the axial symmetry of the strip cross section. In the layered surfacing of mill rolls with the rollers being at an angle to the generatrix, there may be such defects as undercuts and slagging along the edges of the seam, that worsen the quality and performance of the wear resistant layer. According to the results of the metallographic analysis of the sections, it has been established that these defects in the seam at the cross-over of the rolls during the layer-by-layer surfacing are not remelted by the arc and it leads to slag inclusions in the zone. There is an asymmetry in the formation of the weld pool, which is associated with the peculiarities of the liquid metal flow during its melting. Thus, a decrease in the minimum deviation angle of the strip electrode location with respect to the deposition rate vector leads to a decrease in the crack resistance of the working surface. Investigations of the weld bead formation during deposition by a strip electrode as a function of the angle of the strip rotation with respect to the deposition rate vector have been performed. The influence of the change in the angle of rotation of the strip electrode on the uniformity of the fusion line with the parent metal formation was studied. The allowable range of strip angle values has been determined, which ensures the quality and operability of the wear-resistant layer, as well as the absence of formation defects. Analysis of the wear characteristics and fracture toughness of the deposited layer showed that a change in the location of the strip electrode makes it possible to increase the fracture toughness of the welded layer with high quality of its formation and practically unchanged wear resistance

Costs of Producing Biomass from Riparian Buffer Strips

Energy Technology Data Exchange (ETDEWEB)

Turhollow, A.

2000-09-01

Nutrient runoff from poultry litter applied to agricultural fields in the Delmarva Peninsula contributes to high nutrient loadings in Chesapeake Bay. One potential means of ameliorating this problem is the use of riparian buffer strips. Riparian buffer strips intercept overland flows of water, sediments, nutrients, and pollutants; and ground water flows of nutrients and pollutants. Costs are estimated for three biomass systems grown on buffer strips: willow planted at a density of 15,300 trees/ha (6200 trees/acre); poplar planted at a density of 1345 trees/ha (545 trees/acre); and switchgrass. These costs are estimated for five different scenarios: (1) total economic costs, where everything is costed [cash costs, noncash costs (e.g., depreciation), land rent, labor]; (2) costs with Conservation Reserve Program (CRP) payments (which pays 50% of establishment costs and an annual land rent); (3) costs with enhanced CRP payments (which pays 95% of establishment costs and an annual payment of approximately 170% of land rent for trees and 150% of land rent for grasses); (4) costs when buffer strips are required, but harvest of biomass is not required [costs borne by biomass are for yield enhancing activities (e.g., fertilization), harvest, and transport]; and (5) costs when buffer strips are required. and harvest of biomass is required to remove nutrients (costs borne by biomass are for yield enhancing activities and transport). CRP regulations would have to change to allow harvest. Delivered costs of willow, poplar, and switchgrass [including transportation costs of $0.38/GJ ($0.40/million Btu) for switchgrass and $0.57/GJ ($0.60/million Btu) for willow and poplar] at 11.2 dry Mg/ha-year (5 dry tons/acre-year) for the five cost scenarios listed above are [$/GJ ($million BIN)]: (1) 3.30-5.45 (3.45-5.75); (2) 2.30-3.80 (2.45-4.00); (3) 1.70-2.45 (1.80-2.60); (4) l-85-3.80 (1.95-4.05); and (5) 0.80-1.50 (0.85-1.60). At yields of 15.7 to 17.9 GJ/ha-year (7 to 8 dry tons

Effects of fatigue and environment on residual strengths of center-cracked graphite/epoxy buffer strip panels

Science.gov (United States)

Bigelow, Catherine A.

1989-01-01

The effects of fatigue, moisture conditioning, and heating on the residual tension strengths of center-cracked graphite/epoxy buffer strip panels were evaluated using specimens made with T300/5208 graphite epoxy in a 16-ply quasi-isotropic layup, with two different buffer strip materials, Kevlar-49 or S-glass. It was found that, for panels subjected to fatigue loading, the residual strengths were not significantly affected by the fatigue loading, the number of repetitions of the loading spectrum, or the maximum strain level. The moisture conditioning reduced the residual strengths of the S-glass buffer strip panels by 10 to 15 percent below the ambient results, but increased the residual strengths of the Kevlar-49 buffer strip panels slightly. For both buffer strip materials, the heat increased the residual strengths of the buffer strip panels slightly over the ambient results.

Prestressed CFRP Strips with Gradient Anchorage for Structural Concrete Retrofitting: Experiments and Numerical Modeling

Directory of Open Access Journals (Sweden)

Julien Michels

2014-01-01

Full Text Available This paper presents a study on the load carrying capacity of reinforced concrete (RC beams strengthened with externally bonded (EB carbon fiber reinforced polymer (CFRP strips prestressed up to 0.6% in strain. At the strip ends, the innovative gradient anchorage is used instead of conventional mechanical fasteners. This method, based on the epoxy resin’s ability to rapidly cure under high temperatures, foresees a sector-wise heating followed by a gradual decrease of the initial prestress force towards the strip ends. The experimental investigation shows a promising structural behavior, resulting in high strip tensile strains, eventually almost reaching tensile failure of the composite strip. Additionally, ductility when considering deflection at steel yielding and at ultimate load is satisfying, too. From a practical point of view, it is demonstrated that premature strip grinding in the anchorage zone is not beneficial. In addition, a non-commercial 1D finite element code has been enlarged to an EB reinforcement with prestressed composite strips. A bilinear bond stress-slip relation obtained in earlier investigations is introduced as an additional failure criterion to the code. The numerical code is able to almost perfectly predict the overall structural behavior. Furthermore, the calculations are used for comparison purposes between an initially unstressed and a prestressed externally bonded composite reinforcement. The increase in cracking and yielding load, as well as differences in structural stiffness are apparent.

Strip detector for the ATLAS detector upgrade for the High-Luminosity LHC

CERN Document Server

Veloce, Laurelle Maria; The ATLAS collaboration

2017-01-01

The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2025. The expected radiation damage at an integrated luminosity of 3000fb-1 will require the tracking detectors to withstand hadron fluencies to over 1x1016 1 MeV neutron equivalent per cm2. With the addition of increased readout rates, the existing Inner Detector will have to be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four-layer barrel and a forward region composed of six discs on each side of the barrel. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which starts the pre-production readiness phase at the involved institutes. In this contribution we present the design of the ITk Strip Detector and current status of R&D of various detector components.

Rapid on-site detection of Acidovorax avenae subsp. citrulli by gold-labeled DNA strip sensor.

Science.gov (United States)

Zhao, Wenjun; Lu, Jie; Ma, Wenwei; Xu, Chuanlai; Kuang, Hua; Zhu, Shuifang

2011-06-15

Acidovorax avenae subsp. citrulli (AAC) is one of the most harmful diseases in cucurbit production. A rapid and sensitive DNA strip sensor was constructed based on gold nanoparticle-labeled oligonucleotide probes for the detection of AAC. Both the qualitative and semi-quantitative detections of target DNA were successfully achieved using the developed DNA strip sensor. The qualitative limit of detection (LOD) of the strip sensor was determined as 4 nM. The LOD for the semi-quantitative detection was calculated to be 0.48 nM in the range of 0-10 nM. The genomic DNA was detected directly using the DNA strip sensor without any further treatment. This DNA strip sensor is a potentially useful tool for rapid on-site DNA screening. Copyright © 2011 Elsevier B.V. All rights reserved.

Epidermal growth factor and active caspase-3 expression in the levator ani muscle of dogs with and without perineal hernia.

Science.gov (United States)

Pérez-Gutiérrez, J F; Argüelles, J C; Iglesias-Núñez, M; Oliveira, K S; De La Muela, M Sánchez

2011-07-01

To perform a histological and immunohistochemical study of epidermal growth factor, transforming growth factor-alpha and their receptor, as well as the apoptotic signal active caspase-3 in the levator ani muscle of dogs with and without perineal hernia. Biopsy specimens of the levator ani muscle were obtained from 25 dogs with perineal hernia and 4 non-affected dogs and were processed for Masson and immunohistochemical staining. The affected dogs exhibited myopathological features, internalised nuclei, destruction and abnormal size of muscle fibres, which were replaced by collagen. The immunohistochemical study revealed active caspase-3, epidermal growth factor, transforming growth factor-alpha and epidermal growth factor receptor in the levator ani. Compared to the healthy muscle, transforming growth factor-alpha staining intensity was lower in the affected muscle, whereas epidermal growth factor receptor and active caspase-3 staining were higher. Pelvic diaphragm muscle weakening is the leading cause of perineal hernia in the dog. Survival and death signals expressed in these muscles may contribute to the pathogenesis of this disease. This study reports epidermal growth factor, transforming growth factor-alpha and epidermal growth factor receptor immunohistochemical expression in the skeletal muscle and suggests that perineal hernia in the dog is accompanied by levator ani muscle atrophy, increased expression of epidermal growth factor receptor, caspase-3 activation, and decreased expression of transforming growth factor-alpha. © 2011 British Small Animal Veterinary Association.

Screen-Printed Electrodes Modified with "Green" Metals for Electrochemical Stripping Analysis of Toxic Elements.

Science.gov (United States)

Economou, Anastasios

2018-03-29

This work reviews the field of screen-printed electrodes (SPEs) modified with "green" metals for electrochemical stripping analysis of toxic elements. Electrochemical stripping analysis has been established as a useful trace analysis technique offering many advantages compared to competing optical techniques. Although mercury has been the preferred electrode material for stripping analysis, the toxicity of mercury and the associated legal requirements in its use and disposal have prompted research towards the development of "green" metals as alternative electrode materials. When combined with the screen-printing technology, such environment-friendly metals can lead to disposable sensors for trace metal analysis with excellent operational characteristics. This review focuses on SPEs modified with Au, Bi, Sb, and Sn for stripping analysis of toxic elements. Different modification approaches (electroplating, bulk modification, use of metal precursors, microengineering techniques) are considered and representative applications are described. A developing related field, namely biosensing based on stripping analysis of metallic nanoprobe labels, is also briefly mentioned.

Morphometric analysis of epidermal differentiation in primary roots of Zea mays

Science.gov (United States)

Moore, R.; Smith, H. S.

1990-01-01

Epidermal differentiation in primary roots of Zea mays was divided into six cell types based on cellular shape and cytoplasmic appearance. These six cell types are: 1) apical protoderm, located at the tip of the root pole and characterized by periclinally flattened cells; 2) cuboidal protoderm, located approximately 230 microns from the root pole and characterized by cuboidal cells; 3) tabular epidermis, located approximately 450 microns from the root pole and characterized by anticlinally flattened cells; 4) cuboidal epidermis, located approximately 900 microns from the root pole and characterized by cuboidal cells having numerous small vacuoles; 5) vacuolate cuboidal epidermis, located approximately 1,500 microns from the root pole and characterized by cuboidal cells containing several large vacuoles; and 6) columnar epidermis, located approximately 2,200 microns from the root pole (i.e., at the beginning of the zone of elongation) and characterized by elongated cells. We also used stereology to quantify the cellular changes associated with epidermal differentiation. The quiescent center and the apical protoderm have significantly different ultrastructures. The relative volume of dictyosomes increases dramatically during the early stages of epidermal differentiation. This increase correlates inversely with the amount of coverage provided by the root cap and mucilage.

Identification and comparative analysis of the epidermal differentiation complex in snakes

Science.gov (United States)

Brigit Holthaus, Karin; Mlitz, Veronika; Strasser, Bettina; Tschachler, Erwin; Alibardi, Lorenzo; Eckhart, Leopold

2017-01-01

The epidermis of snakes efficiently protects against dehydration and mechanical stress. However, only few proteins of the epidermal barrier to the environment have so far been identified in snakes. Here, we determined the organization of the Epidermal Differentiation Complex (EDC), a cluster of genes encoding protein constituents of cornified epidermal structures, in snakes and compared it to the EDCs of other squamates and non-squamate reptiles. The EDC of snakes displays shared synteny with that of the green anole lizard, including the presence of a cluster of corneous beta-protein (CBP)/beta-keratin genes. We found that a unique CBP comprising 4 putative beta-sheets and multiple cysteine-rich EDC proteins are conserved in all snakes and other squamates investigated. Comparative genomics of squamates suggests that the evolution of snakes was associated with a gene duplication generating two isoforms of the S100 fused-type protein, scaffoldin, the origin of distinct snake-specific EDC genes, and the loss of other genes that were present in the EDC of the last common ancestor of snakes and lizards. Taken together, our results provide new insights into the evolution of the skin in squamates and a basis for the characterization of the molecular composition of the epidermis in snakes. PMID:28345630

Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation.

Science.gov (United States)

Gaviglio, Angela L; Knelson, Erik H; Blobe, Gerard C

2017-05-01

High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma content. The tumor stroma contributes to the suppression of tumor growth by releasing soluble factors that promote neuroblast differentiation. Here we identify heparin-binding epidermal growth factor-like growth factor (HBEGF) as a potent prodifferentiating factor in neuroblastoma. HBEGF mRNA expression is decreased in human neuroblastoma tumors compared with benign tumors, with loss correlating with decreased survival. HBEGF protein is expressed only in stromal compartments of human neuroblastoma specimens, with tissue from high-stage disease containing very little stroma or HBEGF expression. In 3 human neuroblastoma cell lines (SK-N-AS, SK-N-BE2, and SH-SY5Y), soluble HBEGF is sufficient to promote neuroblast differentiation and decrease proliferation. Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor. These data support a role for loss of HBEGF in the neuroblastoma tumor microenvironment in neuroblastoma pathogenesis.-Gaviglio, A. L., Knelson, E. H., Blobe, G. C. Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. © FASEB.

Human eccrine sweat gland cells turn into melanin-uptaking keratinocytes in dermo-epidermal skin substitutes.

Science.gov (United States)

Böttcher-Haberzeth, Sophie; Biedermann, Thomas; Pontiggia, Luca; Braziulis, Erik; Schiestl, Clemens; Hendriks, Bart; Eichhoff, Ossia M; Widmer, Daniel S; Meuli-Simmen, Claudia; Meuli, Martin; Reichmann, Ernst

2013-02-01

Recently, Biedermann et al. (2010) have demonstrated that human eccrine sweat gland cells can develop a multilayered epidermis. The question still remains whether these cells can fulfill exclusive and very specific functional properties of epidermal keratinocytes, such as the incorporation of melanin, a feature absent in sweat gland cells. We added human melanocytes to eccrine sweat gland cells to let them develop into an epidermal analog in vivo. The interaction between melanocytes and sweat gland-derived keratinocytes was investigated. The following results were gained: (1) macroscopically, a pigmentation of the substitutes was seen 2-3 weeks after transplantation; (2) we confirmed the development of a multilayered, stratified epidermis with melanocytes distributed evenly throughout the basal layer; (3) melanocytic dendrites projected to suprabasal layers; and (4) melanin was observed to be integrated into former eccrine sweat gland cells. These skin substitutes were similar or equal to skin substitutes cultured from human epidermal keratinocytes. The only differences observed were a delay in pigmentation and less melanin uptake. These data suggest that eccrine sweat gland cells can form a functional epidermal melanin unit, thereby providing striking evidence that they can assume one of the most characteristic keratinocyte properties.

Pattern of hormone receptors and human epidermal growth factor ...

African Journals Online (AJOL)

Introduction: Breast cancer is the most common cancer among women globally. With immunohistochemistry (IHC), breast cancer is classified into four groups based on IHC profile of estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2/neu) expression, positive (+) and/or ...

Performance assessment of the In-Well Vapor-Stripping System

Energy Technology Data Exchange (ETDEWEB)

Gilmore, T.J.; White, M.D.; Spane, F.A. Jr. [and others

1996-10-01

In-well vapor stripping is a remediation technology designed to preferentially extract volatile organic compounds dissolved in groundwater by converting them to a vapor phase and then treating the vapor. This vapor-stripping system is distinctly different from the more traditional in situ air-sparging concept. In situ sparging takes place in the aquifer formation; in-well vapor stripping takes place within the well casing. The system was field demonstrated at Edwards Air Force Base, California; the first-time demonstration of this technology in the United States. Installation and testing of the system were completed in late 1995, and the demonstration was operated nearly continuously for 6 months (191 days) between January 16 and July 25, 1996. Postdemonstration hydrochemical sampling continued until September 1996. The demonstration was conducted by collaborating researchers from Pacific Northwest National Laboratory (a) and Stanford University as part of an interim cleanup action at the base. Edwards Air Force Base and its environmental subcontractor, Earth Technology Corporation, as well as EG&G Environmental, holders of the commercial rights to the technology, were also significant contributors to the demonstration.

Laboratory testing of the in-well vapor-stripping system

International Nuclear Information System (INIS)

Gilmore, T.J.; Francois, O.

1996-03-01

The Volatile organic Compounds-Arid Integrated Demonstration (VOC-Arid ID) was implemented by the US Department of Energy's (DOE's) Office of Technology Development to develop and test new technologies for the remediation of organic chemicals in the subsurface. One of the technologies being tested under the VOC-Arid ID is the in-well vapor-stripping system. The in-well vapor-stripping concept was initially proposed by researchers at Stanford University and is currently under development through a collaboration between workers at Stanford University and DOE's Pacific Northwest National Laboratory. The project to demonstrate the in-well vapor-stripping technology is divided into three phases: (1) conceptual model and computer simulation, (2) laboratory testing, and (3) field demonstration. This report provides the methods and results of the laboratory testing in which a full-scale replica was constructed and tested above ground in a test facility located at DOE's Hanford Site, Washington. The system is a remediation technology designed to preferentially extract volatile organic compounds (VOCs) from contaminated groundwater by converting them to a vapor phase

The Strip: Las Vegas and the Symbolic Destruction of Spectacle

OpenAIRE

Al, Stefan Johannes

2010-01-01

Over the past 70 years, various actors have dramatically reconfigured the Las Vegas Strip in many forms. I claim that behind the Strip's "reinventions" lies a process of symbolic destruction. Since resorts distinguish themselves symbolically, each new round of capital accumulation relies on the destruction of symbolic capital of existing resorts. A new resort either ups the language within a paradigm, or causes a paradigm shift, which devalues the previous resorts even further. This is why, i...

Extraordinarily Stretchable All-Carbon Collaborative Nanoarchitectures for Epidermal Sensors

KAUST Repository

Cai, Yichen

2017-06-16

Multifunctional microelectronic components featuring large stretchability, high sensitivity, high signal-to-noise ratio (SNR), and broad sensing range have attracted a huge surge of interest with the fast developing epidermal electronic systems. Here, the epidermal sensors based on all-carbon collaborative percolation network are demonstrated, which consist 3D graphene foam and carbon nanotubes (CNTs) obtained by two-step chemical vapor deposition processes. The nanoscaled CNT networks largely enhance the stretchability and SNR of the 3D microarchitectural graphene foams, endowing the strain sensor with a gauge factor as high as 35, a wide reliable sensing range up to 85%, and excellent cyclic stability (>5000 cycles). The flexible and reversible strain sensor can be easily mounted on human skin as a wearable electronic device for real-time and high accuracy detecting of electrophysiological stimuli and even for acoustic vibration recognition. The rationally designed all-carbon nanoarchitectures are scalable, low cost, and promising in practical applications requiring extraordinary stretchability and ultrahigh SNRs.

Extraordinarily Stretchable All-Carbon Collaborative Nanoarchitectures for Epidermal Sensors

KAUST Repository

Cai, Yichen; Shen, Jie; Dai, Ziyang; Zang, Xiaoxian; Dong, Qiuchun; Guan, Guofeng; Li, Lain-Jong; Huang, Wei; Dong, Xiaochen

2017-01-01

Multifunctional microelectronic components featuring large stretchability, high sensitivity, high signal-to-noise ratio (SNR), and broad sensing range have attracted a huge surge of interest with the fast developing epidermal electronic systems. Here, the epidermal sensors based on all-carbon collaborative percolation network are demonstrated, which consist 3D graphene foam and carbon nanotubes (CNTs) obtained by two-step chemical vapor deposition processes. The nanoscaled CNT networks largely enhance the stretchability and SNR of the 3D microarchitectural graphene foams, endowing the strain sensor with a gauge factor as high as 35, a wide reliable sensing range up to 85%, and excellent cyclic stability (>5000 cycles). The flexible and reversible strain sensor can be easily mounted on human skin as a wearable electronic device for real-time and high accuracy detecting of electrophysiological stimuli and even for acoustic vibration recognition. The rationally designed all-carbon nanoarchitectures are scalable, low cost, and promising in practical applications requiring extraordinary stretchability and ultrahigh SNRs.

New developments in double sided silicon strip detectors

International Nuclear Information System (INIS)

Becker, H.; Boulos, T.; Cattaneo, P.; Dietl, H.; Hauff, D.; Holl, P.; Lange, E.; Lutz, G.; Moser, H.G.; Schwarz, A.S.; Settles, R.; Struder, L.; Kemmer, J.; Buttler, W.

1990-01-01

A new type of double sided silicon strip detector has been built and tested using highly density VLSI readout electronics connected to both sides. Capacitive coupling of the strips to the readout electronics has been achieved by integrating the capacitors into the detector design, which was made possible by introducing a new detector biasing concept. Schemes to simplify the technology of the fabrication of the detectors are discussed. The static performance properties of the devices as well as implications of the use of VLSI electronics in their readout are described. Prototype detectors of the described design equipped with high density readout electronics have been installed in the ALEPH detector at LEP. Test results on the performance are given

Effects of thermomechanical processing on titanium aluminide strip cast by the melt overflow process

Energy Technology Data Exchange (ETDEWEB)

Gaspar, T.A. (Ribbon Technology Corporation, PO Box 30758, Columbus, OH 43230 (United States)); Hackman, L.E. (Ribbon Technology Corporation, PO Box 30758, Columbus, OH 43230 (United States)); Batawi, E. (Sulzer-Innotec, Division 1511, PO Box 65, Winterthur 8404 (Switzerland)); Peters, J.A. (Sulzer-Innotec, Division 1511, PO Box 65, Winterthur 8404 (Switzerland))

1994-05-01

The objective of this research project was to investigate the feasibility of producing titanium aluminide foils from direct cast strip using ribbon technology''s plasma melt overflow process. Niobium-modified Ti[sub 3]Al alloys were melted in a cold copper crucible using a transferred plasma arc and then direct cast into strip on a rotating chill roll.Samples cut from the as-cast Ti[sub 3]Al-Nb ([alpha][sub 2]) titanium aluminide strip were encapsulated into a pack. The packs were heated to the rolling temperature and then hot rolled at low strain rates. Foils 70 [mu]m (0.003 in) thick, having a uniform [alpha][sub 2]-B2 microstructure with oxygen contents as low as 900 wt.ppm were obtained after pack rolling. The strips and foils were characterized in terms of microstructure and chemical composition in the as-received, heat-treated and pack-rolled conditions.The results indicated that it was technically feasible to produce foils from direct cast titanium aluminide strip using pack-rolling technology. The advantage of this technology lies in its cost-effectiveness, since the relatively low cost direct-cast titanium aluminide strip was thermomechanically processed into foil with the desired microstructure without any intermediate processing steps. ((orig.))

Performance of the first prototype of the CALICE scintillator strip electromagnetic calorimeter

CERN Document Server

Francis, K.; Schlereth, J.; Smith, J.; Xia, L.; Baldolemar, E.; Li, J.; Park, S.T.; Sosebee, M.; White, A.P.; Yu, J.; Eigen, G.; Mikami, Y.; Watson, N.K.; Thomson, M.A.; Ward, D.R.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Apostolakis, J.; Dotti, A.; Folger, G.; Ivantchenko, V.; Ribon, A.; Uzhinskiy, V.; Carloganu, C.; Gay, P.; Manen, S.; Royer, L.; Tytgat, M.; Zaganidis, N.; Blazey, G.C.; Dyshkant, A.; Lima, J.G.R.; Zutshi, V.; Hostachy, J. -Y.; Morin, L.; Cornett, U.; David, D.; Ebrahimi, A.; Falley, G.; Gadow, K.; Goettlicher, P.; Guenter, C.; Hartbrich, O.; Hermberg, B.; Karstensen, S.; Krivan, F.; Krueger, K.; Lutz, B.; Morozov, S.; Morgunov, V.; Neubueser, C.; Reinecke, M.; Sefkow, F.; Smirnov, P.; Terwort, M.; Garutti, E.; Laurien, S.; Lu, S.; Marchesini, I.; Matysek, M.; Ramilli, M.; Briggl, K.; Eckert, P.; Harion, T.; Schultz-Coulon, H. -Ch.; Shen, W.; Stamen, R.; Bilki, B.; Norbeck, E.; Northacker, D.; Onel, Y.; Wilson, G.W.; Kawagoe, K.; Sudo, Y.; Yoshioka, T.; Dauncey, P.D.; Wing, M.; Salvatore, F.; Cortina Gil, E.; Mannai, S.; Baulieu, G.; Calabria, P.; Caponetto, L.; Combaret, C.; Della Negra, R.; Grenier, G.; Han, R.; Ianigro, J-C.; Kieffer, R.; Laktineh, I.; Lumb, N.; Mathez, H.; Mirabito, L.; Petrukhin, A.; Steen, A.; Tromeur, W.; Vander donckt, M.; Zoccarato, Y.; Calvo Alamillo, E.; Fouz, M.-C.; Puerta-Pelayo, J.; Corriveau, F.; Bobchenko, B.; Chadeeva, M.; Danilov, M.; Epifantsev, A.; Markin, O.; Mizuk, R.; Novikov, E.; Popov, V.; Rusinov, V.; Tarkovsky, E.; Besson, D.; Buzhan, P.; Ilyin, A.; Kantserov, V.; Kaplin, V.; Karakash, A.; Popova, E.; Tikhomirov, V.; Kiesling, C.; Seidel, K.; Simon, F.; Soldner, C.; Weuste, L.; Amjad, M.S.; Bonis, J.; Callier, S.; Conforti di Lorenzo, S.; Cornebise, P.; Doublet, Ph.; Dulucq, F.; Fleury, J.; Frisson, T.; van der Kolk, N.; Li, H.; Martin-Chassard, G.; Richard, F.; de la Taille, Ch.; Poeschl, R.; Raux, L.; Rouene, J.; Seguin-Moreau, N.; Anduze, M.; Balagura, V.; Boudry, V.; Brient, J-C.; Cornat, R.; Frotin, M.; Gastaldi, F.; Guliyev, E.; Haddad, Y.; Magniette, F.; Musat, G.; Ruan, M.; Tran, T.H.; Videau, H.; Bulanek, B.; Zacek, J.; Cvach, J.; Gallus, P.; Havranek, M.; Janata, M.; Kvasnicka, J.; Lednicky, D.; Marcisovsky, M.; Polak, I.; Popule, J.; Tomasek, L.; Tomasek, M.; Ruzicka, P.; Sicho, P.; Smolik, J.; Vrba, V.; Zalesak, J.; Belhorma, B.; Ghazlane, H.; Kotera, K.; Ono, H.; Takeshita, T.; Uozumi, S.; Jeans, D.; Chang, S.; Khan, A.; Kim, D.H.; Kong, D.J.; Oh, Y.D.; Goetze, M.; Sauer, J.; Weber, S.; Zeitnitz, C.

2014-11-01

A first prototype of a scintillator strip-based electromagnetic calorimeter was built, consisting of 26 layers of tungsten absorber plates interleaved with planes of 45x10x3 mm3 plastic scintillator strips. Data were collected using a positron test beam at DESY with momenta between 1 and 6 GeV/c. The prototype's performance is presented in terms of the linearity and resolution of the energy measurement. These results represent an important milestone in the development of highly granular calorimeters using scintillator strip technology. This technology is being developed for a future linear collider experiment, aiming at the precise measurement of jet energies using particle flow techniques.

Teaching the Sociology of Sport: Using a Comic Strip in the Classroom.

Science.gov (United States)

Snyder, Eldon E.

1997-01-01

Observes that contemporary sociology pays little attention to the narrative and graphic aspects of comic strips. Presents classroom experiences using "Gil Thorpe," a comic strip with an ongoing storyline about suburban high school athletics, and gives reasons for the effectiveness of this instructional tool in the sociology of sport.…

78 FR 35245 - Polyethylene Terephthalate Film, Sheet, and Strip From the People's Republic of China: Final...

Science.gov (United States)

2013-06-12

... polyethylene terephthalate film, sheet, and strip (``PET film'') from the People's Republic of China (``PRC... Film, Sheet, and Strip From the People's Republic of China: Final Results of Antidumping Duty..., 2011. \\1\\ See Polyethylene Terephthalate Film, Sheet, and Strip From the People's Republic of China...

The extent of the stop coannihilation strip

Energy Technology Data Exchange (ETDEWEB)

Ellis, John [King' s College London, Theoretical Particle Physics and Cosmology Group, Department of Physics, London (United Kingdom); CERN, Theory Division, Geneva 23 (Switzerland); Olive, Keith A. [University of Minnesota, School of Physics and Astronomy, Minneapolis, MN (United States); University of Minnesota, William I. Fine Theoretical Physics Institute, School of Physics and Astronomy, Minneapolis, MN (United States); Zheng, Jiaming [University of Minnesota, School of Physics and Astronomy, Minneapolis, MN (United States)

2014-07-15

Many supersymmetric models such as the constrained minimal supersymmetric extension of the Standard Model (CMSSM) feature a strip in parameter space where the lightest neutralino χ is identified as the lightest supersymmetric particle, the lighter stop squark t{sub 1} is the next-to-lightest supersymmetric particle (NLSP), and the relic χ cold darkmatter density is brought into the range allowed by astrophysics and cosmology by coannihilation with the lighter stop squark t{sub 1} NLSP. We calculate the stop coannihilation strip in the CMSSM, incorporating Sommerfeld enhancement effects, and we explore the relevant phenomenological constraints and phenomenological signatures. In particular, we show that the t{sub 1} may weigh several TeV, and its lifetime may be in the nanosecond range, features that are more general than the specific CMSSM scenarios that we study in this paper. (orig.)

Visual method for detecting critical damage in railway contact strips

Science.gov (United States)

Judek, S.; Skibicki, J.

2018-05-01

Ensuring an uninterrupted supply of power in the electric traction is vital for the safety of this important transport system. For this purpose, monitoring and diagnostics of the technical condition of the vehicle’s power supply elements are becoming increasingly common. This paper presents a new visual method for detecting contact strip damage, based on measurement and analysis of the movement of the overhead contact line (OCL) wire. A measurement system configuration with a 2D camera was proposed. The experimental method has shown that contact strips damage can be detected by transverse displacement signal analysis. It has been proven that the velocity signal numerically established on that basis has a comparable level in the case of identical damage, regardless of its location on the surface of the contact strip. The proposed method belongs to the group of contact-less measurements, so it does not require interference with the structure of the catenary network nor the mounting of sensors in its vicinity. Measurement of displacements of the contact wire in 2D space makes it possible to combine the functions of existing diagnostic stands assessing the correctness of the mean contact force control adjustment of the current collector with the elements of the contact strip diagnostics, which involves detecting their damage which may result in overhead contact line rupture.

Two methods to estimate the position resolution for straw chambers with strip readout

International Nuclear Information System (INIS)

Golutvin, I.A.; Movchan, S.A.; Peshekhonov, V.D.; Preda, T.

1992-01-01

The centroid and charge-ratio methods are presented to estimate the position resolution of the straw chambers with strip readout. For the straw chambers of 10 mm in diameter, the highest position resolution was obtained for a strip pitch of 5 mm. With the centroid method and perpendicular X-ray beam, the position resolution was ≅120 μm, for the signal-to-noise ratio of 60-65. The charge-ratio method has demonstrated ≅10% better position resolution at the edges of the strip. 6 refs.; 5 figs

Experimental Investigations on the Pull-Out Behavior of Tire Strips Reinforced Sands.

Science.gov (United States)

Li, Li-Hua; Chen, Yan-Jun; Ferreira, Pedro Miguel Vaz; Liu, Yong; Xiao, Heng-Lin

2017-06-27

Waste tires have excellent mechanical performance and have been used as reinforcing material in geotechnical engineering; however, their interface properties are poorly understood. To further our knowledge, this paper examines the pull-out characteristics of waste tire strips in a compacted sand, together with uniaxial and biaxial geogrids also tested under the same conditions. The analysis of the results shows that the interlocking effect and pull-out resistance between the tire strip and the sand is very strong and significantly higher than that of the geogrids. In the early stages of the pull-out test, the resistance is mainly provided by the front portion of the embedded tire strips, as the pull-out test continues, more and more of the areas towards the end of the tire strips are mobilized, showing a progressive failure mechanism. The deformations are proportional to the frictional resistance between the tire-sand interface, and increase as the normal stresses increase. Tire strips of different wear intensities were tested and presented different pull-out resistances; however, the pull-out resistance mobilization patterns were generally similar. The pull-out resistance values obtained show that rubber reinforcement can provide much higher pull-out forces than the geogrid reinforcements tested here, showing that waste tires are an excellent alternative as a reinforcing system, regardless of the environmental advantages.

ANALYSIS ON THE BEHAVIOR OF PRECIPITATES IN ULTRA-THIN HOT STRIP OF PLAIN LOW CARBON STEEL PRODUCED BY COMPACT STRIP PRODUCTION

Institute of Scientific and Technical Information of China (English)

H. Yu; Y.L. Kang; H.B. Dong; D.L. Liu; J. Fu

2002-01-01

This paper investigated the mechanism of precipitation and its influence upon prop-erties of ultra-thin hot strips of low carbon steel produced by CSP techniques usingexperiment and thermodynamics theory. The experimental results show that thereare lots of fine and dispersive precipitates in microstructures. By analysis, most ofaluminum nitrides are in grains, while coexisted precipitates of MnS are along grainboundaries. Coexisted precipitates compose cation-vacancy type oxides such as Al2O3in the core, while MnS is at the fringe of surface. The precipitation behavior of AlNand MnS in the hot strip is studied by thermodynamic calculation. At last, implica-tions between strengthening effect and techniques are analyzed using obtained solubilityproducts.

Glucose meters: evaluation of the new formulation measuring strips from Roche (Accu-Chek) and Abbott (MediSense).

Science.gov (United States)

Dimeski, G; Jones, B W; Tilley, V; Greenslade, M N; Russell, A W

2010-07-01

Both Roche and Abbott have released new glucose meter strips. They supply the entire Australian hospital market. The present study compared the performance of the new strips utilizing various specimen types (capillary, venous lithium heparin whole blood, venous lithium heparin plasma and serum) and evaluated how well they comply with the International Standards Organization (ISO) 15197 criteria. The study included imprecision, patient comparison and interference studies. Participants with and without diabetes were recruited to evaluate the performance of various specimen types against the Beckman DxC800 glucose method. The strips were tested for different interferences: galactose, maltose, lactose, Icodextrin, Intragam, paracetamol, sodium, ascorbic acid, variable strip storage temperature, haematocrit, haemolysis and lipaemia. The imprecision of the two strips was approximately 5% or less, except for the Abbott strip at very low values (1.4 mmol/L), approximately 7%. In total, 78% and 84%, respectively, of the results from the finger prick capillary specimens with the Roche (Accu-Chek Performa meter) and Abbott (Optium Xceed meter) strips, not 95% or greater as recommended by the ISO guideline, were within the recommended limits compared with reference plasma estimation on laboratory analysers. Galactose, ascorbic acid, haematocrit and sodium on the Roche and ascorbic acid and haematocrit on the Abbott strip continue to interfere to a variable degree with the glucose measurement. Analytically small differences exist between the glucose meter strips. The most significant analytical difference with the strips was at low glucose levels when compared with laboratory analyses and this may be of clinical importance. The impact of some of the interferences is variable between the two strips. Individuals, health-care professionals and health-care institutions should consider these data when selecting glucose meters for the management of people with diabetes mellitus.

A History of H i Stripping in Virgo: A Phase-space View of VIVA Galaxies

Energy Technology Data Exchange (ETDEWEB)

Yoon, Hyein; Chung, Aeree; Smith, Rory [Department of Astronomy, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722 (Korea, Republic of); Jaffé, Yara L., E-mail: hiyoon@galaxy.yonsei.ac.kr, E-mail: achung@yonsei.ac.kr [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago (Chile)

2017-04-01

We investigate the orbital histories of Virgo galaxies at various stages of H i gas stripping. In particular, we compare the location of galaxies with different H i morphology in phase space. This method is a great tool for tracing the gas stripping histories of galaxies as they fall into the cluster. Most galaxies at the early stage of H i stripping are found in the first infall region of Virgo, while galaxies undergoing active H i stripping mostly appear to be falling in or moving out near the cluster core for the first time. Galaxies with severely stripped, yet symmetric, H i disks are found in one of two locations. Some are deep inside the cluster, but others are found in the cluster outskirts with low orbital velocities. We suggest that the latter group of galaxies belong to a “backsplash” population. These present the clearest candidates for backsplashed galaxies observationally identified to date. We further investigate the distribution of a large sample of H i-detected galaxies toward Virgo in phase space, confirming that most galaxies are stripped of their gas as they settle into the gravitational potential of the cluster. In addition, we discuss the impact of tidal interactions between galaxies and group preprocessing on the H i properties of the cluster galaxies, and link the associated star formation evolution to the stripping sequence of cluster galaxies.

In-well vapor stripping drilling and characterization work plan

International Nuclear Information System (INIS)

Koegler, K.J.

1994-01-01

This work plan provides the information necessary for drilling, sampling, and hydrologic testing of wells to be completed in support of a demonstration of the in-well vapor stripping system. The in-well vapor stripping system is a remediation technology designed to preferentially extract volatile organic compounds (VOCs) from contaminated groundwater by converting them to a vapor phase. Air-lift pumping is used to lift and aerate groundwater within the well. The volatiles escaping the aerated water are drawn off by a slight vacuum and treated at the surface while the water is allowed to infiltrate the vadose zone back to the watertable

Evaluation of Nobuto filter paper strips for the detection of avian influenza virus antibody in waterfowl

Science.gov (United States)

Dusek, Robert J.; Hall, Jeffrey S.; Nashold, Sean W.; Teslaa, Joshua L.; Ip, Hon S.

2011-01-01

The utility of using Nobuto paper strips for the detection of avian influenza antibodies was examined in mallards (Anas platyrhynchos) experimentally infected with low pathogenic avian influenza viruses. Blood was collected 2 wk after infection and was preserved either as serum or whole blood absorbed onto Nobuto strips. Analysis of samples using a commercially available blocking enzyme-linked immunosorbent assay revealed comparable results (???96% sensitivity for all methods) between sera stored at -30 C and the Nobuto strip preservation method even when the Nobuto strips were stored up to 3 mo at room temperature (RT). Significant differences were detected in the ratio of sample absorbance to negative control absorbance for Nobuto strips stored at RT compared with sera stored at -30 C, although these differences did not affect the ability of the test to reliably detect positive and negative samples. Nobuto strips are a convenient and sensitive alternative to the collection of serum samples when maintaining appropriate storage temperatures is difficult. ?? 2011 American Association of Avian Pathologists.

Effect of Strip Mining on Water Quality in Small Streams in Eastern Kentucky, 1967-1975

Science.gov (United States)

Kenneth L. Dyer; Willie R. Curtis

1977-01-01

Eight years of streamflow data are analyzed to show the effects of strip mining on chemical quality of water in six first-order streams in Breathitt County, Kentucky. All these watersheds were unmined in August, 1967, but five have since been strip mined. The accumulated data from this case history study indicate that strip mining causes large increases in the...

Study of mechanism on microstructure refinement during compact strip production process

International Nuclear Information System (INIS)

Yu Hao; Kang Yonglin; Wang Kelu; Fu Jie; Wang Zhongbing; Liu Delu

2003-01-01

In this study, microstructures of 1.9 mm hot strip steel produced by compact strip production (CSP) are investigated by using optical metallograph observation and electron back-scattered diffraction (EBSD) data to deduce the status of hot rolled austenite before phase transformation, because the evolution of hot rolled austenite is important to provide information for the microstructure refinement. The experimental results show that the finishing hot rolled microstructure is a mixture of recrystallized and deformed austenite, and the percentage of recrystallized austenite is greater than that of the deformed austenite. At last, microstructure evolution of austenite is modeled based on chemical compositions and techniques of producing 1.9 mm hot strip. The simulation results agree well with experimental data. Analysis shows that microstructure refinement, recrystallization and supercooling rate are the primary causes to fine microstructure

Physical distribution of oak strip flooring 1969

Science.gov (United States)

William C. Miller; William C. Miller

1971-01-01

As an aid to the marketing of oak strip flooring, a study was made of the distribution process for this product, from manufacture to consumer-where the flooring came from, where it went, how much was shipped, and who handled it.

Linear sweep anodic stripping voltammetry: Determination of ...

Indian Academy of Sciences (India)

The aim of this work is to determine Cr(VI) in water resources by anodic stripping voltammetry using SPE-. AuNPs modified electrode .... surface area about 4 fold). 3.2 Optimization of Parameters ..... in water samples. The above system offers a.

75 FR 81308 - Stainless Steel Sheet And Strip From Germany, Italy, Japan, Korea, Mexico, And Taiwan

Science.gov (United States)

2010-12-27

...)] Stainless Steel Sheet And Strip From Germany, Italy, Japan, Korea, Mexico, And Taiwan AGENCY: United States... and strip from Germany, Italy, Japan, Korea, Mexico, and Taiwan. SUMMARY: The Commission hereby gives... strip from Germany, Italy, Japan, Korea, Mexico, and Taiwan would be likely to lead to continuation or...

75 FR 59744 - Stainless Steel Sheet and Strip From Germany, Italy, Japan, Korea, Mexico, and Taiwan

Science.gov (United States)

2010-09-28

...)] Stainless Steel Sheet and Strip From Germany, Italy, Japan, Korea, Mexico, and Taiwan AGENCY: United States... duty orders on stainless steel sheet and strip from Germany, Italy, Japan, Korea, Mexico, and Taiwan... stainless steel sheet and strip from Germany, Italy, Japan, Korea, Mexico, and Taiwan would be likely to...

The ATLAS Tracker Upgrade: Short Strips Detectors for the SLHC

CERN Document Server

Soldevila, U; Lacasta, C; Marti i García, S; Miñano, M

2009-01-01

It is foreseen to increase the luminosity of the Large Hadron Collider (LHC) at CERN around 2018 by about an order of magnitude, with the upgraded machine dubbed Super-LHC or sLHC. The ATLAS experiment will require a new tracker for SLHC operation. In order to cope with the order of magnitude increase in pile-up backgrounds at the higher luminosity, an all silicon detector is being designed. The new strip detector will use significantly shorter strips than the current SCT in order to minimise the occupancy. As the increased luminosity will mean a corresponding increase in radiation dose, a new generation of extremely radiation hard silicon detectors is required. A massive R&D programme is underway to develop silicon sensors with sufficient radiation hardness. New front-end electronics and readout systems are being designed to cope with the higher data rates. The challenges of powering and cooling a very large strip detector will be discussed. Ideas on possible schemes for the layout and support mechanics ...

Use of etanercept to treat toxic epidermal necrolysis in a human immunodeficiency virus-positive patient

OpenAIRE

Yung-Yi Lee; Jui-Hung Ko; Chia-Hung Wei; Wen-Hung Chung

2013-01-01

Toxic epidermal necrolysis (TEN) is an uncommon and severe cutaneous adverse drug reaction that causes disseminated necrosis of epidermal cells and mucocutaneous detachment. Here, we report the case of a 32-year-old man with human immunodeficiency virus infection who presented with generalized violaceous macules and blister formation 4 days after the administration of mefenamic acid and amoxicillin for a dental procedure. Additional symptoms included oral ulcers and conjunctivitis. Results of...

Humor in Elementary Science: Development and Evaluation of Comic Strips about Sound

Science.gov (United States)

Özdemir, Ertugrul

2017-01-01

Comic strips on newspapers, magazines and Internet are one of the most accessible materials that may be used in science classroom as instructional tool. However, it is sometimes difficult to find and adapt appropriate comic strips useful for instructional purposes, because most of them are irrelevant. The purpose of this study is to develop and…

Epidermal response of rainbow trout to Ichthyobodo necator

DEFF Research Database (Denmark)

Chettri, Jiwan Kumar; Kuhn, Jesper Andreas; Mohammad, Rezkar Jaafar

2014-01-01

Infections with the parasitic flagellate Ichthyobodo necator (Henneguy, 1883) cause severe skin and gill disease in rainbow trout Oncorhynchus mykiss (Walbaum, 1792) juveniles. The epidermal disturbances including hyperplasia and mucous cell exhaustion caused by parasitization are known, but no d...

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion

DEFF Research Database (Denmark)

Piwko-Czuchra, Aleksandra; Koegel, Heidi; Meyer, Hannelore

2009-01-01

BACKGROUND: There is a major discrepancy between the in vitro and in vivo results regarding the role of beta1 integrins in the maintenance of epidermal stem/progenitor cells. Studies of mice with skin-specific ablation of beta1 integrins suggested that epidermis can form and be maintained in thei...... of increased keratinocyte proliferation such as wound healing. CONCLUSIONS/SIGNIFICANCE: These data demonstrate that expression of beta1 integrins is critically important for the expansion of epidermal progenitor cells to maintain epidermal homeostasis....... that developed similar, but less severe defects than mice with beta1-deficient keratinocytes. Surprisingly we found that upon aging these abnormalities attenuated due to a rapid expansion of cells, which escaped or compensated for the down-regulation of beta1 integrin expression. A similar phenomenon...... was observed in aged mice with a complete, skin-specific ablation of the beta1 integrin gene, where cells that escaped Cre-mediated recombination repopulated the mutant skin in a very short time period. The expansion of beta1 integrin expressing keratinocytes was even further accelerated in situations...

Design of the first full size ATLAS ITk Strip sensor for the endcap region

CERN Document Server

Lacasta, Carlos; The ATLAS collaboration

2017-01-01

The ATLAS collaboration is designing the full silicon tracker (ITk) that will operate in the HL-LHC replacing the current design. The silicon microstrip sensors for the barrel and the endcap regions in the ITk are fabricated in 6 inch, p-type, float-zone wafers, where large-area strip sensor designs are laid out together with a number of miniature sensors. The radiation tolerance and specific system issues like the need for slim edge of 450 µm have been tested with square shaped sensors intended for the barrel part of the tracker. This work presents the design of the first full size silicon microstrip sensor for the endcap region with a slim edge of 450 µm. The strip endcaps will consist of several wheels with two layers of silicon strip sensors each. The strips have to lie along the azimuthal direction, apart from a small stereo angle rotation (20 mrad on each side, giving 40 mrad total) for measuring the second coordinate of tracks. This stereo angle is built into the strip layout of the sensor and, in or...

Design of the first full size ATLAS ITk Strip sensor for the endcap region

CERN Document Server

Lacasta, Carlos; The ATLAS collaboration

2018-01-01

The ATLAS collaboration is designing the full silicon tracker (ITk) that will operate in the HL-LHC replacing the current design. The silicon microstrip sensors for the barrel and the endcap regions in the ITk are fabricated in 6 inch, p-type, float-zone wafers, where large-area strip sensor designs are laid out together with a number of miniature sensors. The radiation tolerance and specific system issues like the need for slim edge of 450 μm have been tested with square shaped sensors intended for the barrel part of the tracker. This work presents the design of the first full size silicon microstrip sensor for the endcap region with a slim edge of 450 μm. The strip endcaps will consist of several wheels with two layers of silicon strip sensors each. The strips have to lie along the azimuthal direction, apart from a small stereo angle rotation (20 mrad on each side, giving 40 mrad total) for measuring the second coordinate of tracks. This stereo angle is built into the strip layout of the sensor and, in or...

Nonlinear fractional differential equations and inclusions of arbitrary order and multi-strip boundary conditions

Directory of Open Access Journals (Sweden)

Bashir Ahmad

2012-06-01

Full Text Available We study boundary value problems of nonlinear fractional differential equations and inclusions of order $q in (m-1, m]$, $m ge 2$ with multi-strip boundary conditions. Multi-strip boundary conditions may be regarded as the generalization of multi-point boundary conditions. Our problem is new in the sense that we consider a nonlocal strip condition of the form: $$ x(1=sum_{i=1}^{n-2}alpha_i int^{eta_i}_{zeta_i} x(sds, $$ which can be viewed as an extension of a multi-point nonlocal boundary condition: $$ x(1=sum_{i=1}^{n-2}alpha_i x(eta_i. $$ In fact, the strip condition corresponds to a continuous distribution of the values of the unknown function on arbitrary finite segments $(zeta_i,eta_i$ of the interval $[0,1]$ and the effect of these strips is accumulated at $x=1$. Such problems occur in the applied fields such as wave propagation and geophysics. Some new existence and uniqueness results are obtained by using a variety of fixed point theorems. Some illustrative examples are also discussed.

Root Canal Stripping: Malpractice or Common Procedural Accident-An Ethical Dilemma in Endodontics.

Science.gov (United States)

Ciobanu, Ionela Elisabeta; Rusu, Darian; Stratul, Stefan-Ioan; Didilescu, Andreea Cristina; Cristache, Corina Marilena

2016-01-01

Root canal stripping is defined as an oblong, vertical perforation that appears especially in the middle section of curved root canals during endodontic treatments with nickel-titanium (Ni-Ti) instruments. Its occurrence may drastically affect the outcome of the treatment, transforming a common otherwise efficient endodontic procedure into a complication such as tooth extraction. In order to discuss the ethical and legal consequences, two cases of dental strip perforations are herewith presented. Due to the existence of risk factors for dental strip perforation, experience of the clinician and the use of magnification and modern imagistic methods (CBCT) may avoid or reduce the frequency of this type of accidents. Under correct working circumstances, dental stripping should not be regarded as a malpractice but as a procedural accident. However, the patient must always be informed, before and during the endodontic procedure, about the event and the possible complications that may occur.

Fully stripped heavy ion yield vs energy for Xe and Au ions

International Nuclear Information System (INIS)

Thieberger, P.; Wegner, H.E.; Alonzo, J.; Gould, H.; Anholt, R.E.; Meyerhof, W.E.

1985-01-01

The Bevalac is now capable of accelerating U-238 ions to approximately 1 GeV/amu and measurements have shown that fully stripped U-238 ions are produced with good yield at these energies. However, knowing the stripping yields at different energies for U-238 does not allow an accurate prediction for other, lower Z projectiles. Consequently, extensive stripping yield measurements were made for Au-197 and Xe-139 ions. In addition to the stripping measurements from the direct Bevalac beam, pickup measurements were also made with specially prepared bare, one electron, and two electron ions. Since many research groups are considering heavy ion storage rings and/or synchrotrons, the pickup cross section for bare ions is important to estimate beam lifetime in terms of the average machine vacuum. Since the Mylar target provides a pickup probability similar to air, a preliminary analysis of the Xe 54+ and U 92+ data are presented along with predictions for other ions ranging down to Fe 26+ . 11 refs., 3 figs., 1 tab

Fully stripped heavy ion yield vs energy for Xe and Au ions

Energy Technology Data Exchange (ETDEWEB)

Thieberger, P.; Wegner, H.E.; Alonzo, J.; Gould, H.; Anholt, R.E.; Meyerhof, W.E.

1985-01-01

The Bevalac is now capable of accelerating U-238 ions to approximately 1 GeV/amu and measurements have shown that fully stripped U-238 ions are produced with good yield at these energies. However, knowing the stripping yields at different energies for U-238 does not allow an accurate prediction for other, lower Z projectiles. Consequently, extensive stripping yield measurements were made for Au-197 and Xe-139 ions. In addition to the stripping measurements from the direct Bevalac beam, pickup measurements were also made with specially prepared bare, one electron, and two electron ions. Since many research groups are considering heavy ion storage rings and/or synchrotrons, the pickup cross section for bare ions is important to estimate beam lifetime in terms of the average machine vacuum. Since the Mylar target provides a pickup probability similar to air, a preliminary analysis of the Xe/sup 54 +/ and U/sup 92 +/ data are presented along with predictions for other ions ranging down to Fe/sup 26 +/. 11 refs., 3 figs., 1 tab.

Evaluating the Whitening and Microstructural Effects of a Novel Whitening Strip on Porcelain and Composite Dental Materials.

Science.gov (United States)

Takesh, Thair; Sargsyan, Anik; Lee, Matthew; Anbarani, Afarin; Ho, Jessica; Wilder-Smith, Petra

2017-08-01

The aim of this project was to evaluate the effects of 2 different whitening strips on color, microstructure and roughness of tea stained porcelain and composite surfaces. 54 porcelain and 72 composite chips served as samples for timed application of over-the-counter (OTC) test or control dental whitening strips. Chips were divided randomly into three groups of 18 porcelain and 24 composite chips each. Of these groups, 1 porcelain and 1 composite set served as controls. The remaining 2 groups were randomized to treatment with either Oral Essentials ® Whitening Strips or Crest ® 3D White Whitestrips™. Sample surface structure was examined by light microscopy, profilometry and Scanning Electron Microscopy (SEM). Additionally, a reflectance spectrophotometer was used to assess color changes in the porcelain and composite samples over 24 hours of whitening. Data points were analyzed at each time point using ANOVA. In the light microscopy and SEM images, no discrete physical defects were observed in any of the samples at any time points. However, high-resolution SEM images showed an appearance of increased surface roughness in all composite samples. Using profilometry, significantly increased post-whitening roughness was documented in the composite samples exposed to the control bleaching strips. Composite samples underwent a significant and equivalent shift in color following exposure to Crest ® 3D White Whitestrips™ and Oral Essentials ® Whitening Strips. A novel commercial tooth whitening strip demonstrated a comparable beaching effect to a widely used OTC whitening strip. Neither whitening strip caused physical defects in the sample surfaces. However, the control strip caused roughening of the composite samples whereas the test strip did not.

Numerical simulations of stripping effects in high-intensity hydrogen ion linacs

Directory of Open Access Journals (Sweden)

J.-P. Carneiro

2009-04-01

Full Text Available Numerical simulations of H^{-} stripping losses from blackbody radiation, electromagnetic fields, and residual gas have been implemented into the beam dynamics code TRACK. Estimates of the stripping losses along two high-intensity H^{-} linacs are presented: the Spallation Neutron Source linac currently being operated at Oak Ridge National Laboratory and an 8 GeV superconducting linac currently being designed at Fermi National Accelerator Laboratory.

A Portable Colloidal Gold Strip Sensor for Clenbuterol and Ractopamine Using Image Processing Technology

Directory of Open Access Journals (Sweden)

Yi Guo

2013-01-01

Full Text Available A portable colloidal golden strip sensor for detecting clenbuterol and ractopamine has been developed using image processing technology, as well as a novel strip reader has achieved innovatively with this imaging sensor. Colloidal gold strips for clenbuterol and ractopamine is used as first sensor with given biomedical immunication reaction. After three minutes the target sample dropped on, the color showing in the T line is relative to the content of objects as clenbuterol, this reader can finish many functions like automatic acquit ion of colored strip image, quantatively analysis of the color lines including the control line and test line, and data storage and transfer to computer. The system is integrated image collection, pattern recognition and real-time colloidal gold quantitative measurement. In experiment, clenbuterol and ractopamine standard substance with concentration from 0 ppb to 10 ppb is prepared and tested, the result reveals that standard solutions of clenbuterol and ractopamine have a good secondary fitting character with color degree (R2 is up to 0.99 and 0.98. Besides, through standard sample addition to the object negative substance, good recovery results are obtained up to 98 %. Above all, an optical sensor for colloidal strip measure is capable of determining the content of clenbuterol and ractopamine, it is likely to apply to quantatively identifying of similar reaction of colloidal golden strips.

Treatment of Alkaline Stripped Effluent in Aerated Constructed Wetlands: Feasibility Evaluation and Performance Enhancement

Directory of Open Access Journals (Sweden)

Keli He

2016-09-01

Full Text Available Ammonium stripping has gained increasing interest for nitrogen recovery in anaerobically digested effluents. However, the stripped effluents often still do not meet discharge standards, having high pH and residual pollutants. Constructed wetlands (CWs are an easy to operate ecosystem and have a long history of application in treatment of wastewaters with extreme pH, such as acid mine drainage. However, knowledge of the mechanistic details involved in the use of CWs to treat high alkaline drainage, such as stripped effluent, is insufficient. This study explored the feasibility and effectiveness of using three sub-surface horizontal flow CWs to treat high alkaline stripped effluent (pH > 10. Two intensification strategies—intermittent aeration and effluent recirculation—were evaluated to enhance nitrogen depuration performance. The results show that the treatment of alkaline stripped effluent is feasible due to the high buffering capacity of the wetlands. Effluent recirculation combined with intermittent artificial aeration improves nitrogen removal, with 71% total nitrogen (TN removal. Ammonia volatilization from the surface of the wetlands in high alkaline conditions only contributed to 3% of the total removed ammonium. The microbial abundance and activity had significant diversity for the various enhancement strategies used in the constructed wetland systems. Anammox is an important process for nitrogen removal in CWs treating alkaline stripped effluent, and possible enhancements of this process should be investigated further.

The Whipple Strip Sky Survey

Science.gov (United States)

Kertzman, M. P.

As part of the normal operation of the Whipple 10m Gamma Ray telescope, ten minute drift scan “zenith” runs are made each night of observation for use as calibration. Most of the events recorded during a zenith run are due to the background of cosmic ray showers. However, it would be possible for a hitherto unknown source of gamma rays to drift through the field. This paper reports the results of a search for serendipitous high energy gamma ray sources in the Whipple 10m nightly calibration zenith data. From 2000-2004 nightly calibration runs were taken at an elevation of 89 º. A 2- D analysis of these drift scan runs produces a strip of width ~ 3.5º in declination and spanning the full range of right ascension. In the 2004-05 observing season the calibration runs were taken at elevations of 86° and 83°. Beginning in the 2005-06 season, the nightly calibration runs were taken at an elevation of 80º. Collectively, these drift scans cover a strip approximately 12.5º wide in declination, centered at declination 37.18º, and spanning the full range of RA. The analysis procedures developed for drift scan data, the sensitivity of the method, and the results will be presented.

Cervi cornus Colla (deer antler glue) induce epidermal differentiation in the reconstruction of skin equivalents.

Science.gov (United States)

Choi, H-R; Nam, K-M; Kim, D-S; Huh, C-H; Na, J-I; Park, K-C

2013-06-01

In the reconstruction of skin equivalents (SEs), keratinocyte differentiation is important because epidermal differentiation is closely related with barrier function. The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) on the stem cell activity and epidermal differentiation in the reconstruction of skin equivalent. Four different models were constructed according to different composition of dermal substitute. Results showed similar morphologic findings when hyaluronic acid (HA) and/or CCC was added. But, immunohistochemical staining showed that p63 was significantly increased by addition of HA and/or CCC. Increased staining of integrin α6 and β1 was variably observed when HA and/or CCC was added to make dermal substitute. These finding showed that addition of HA and/or CCC may affect the stem cell activity in the reconstruction of skin. Furthermore, filaggrin expression was much increased when CCC was added. It showed that epidermal differentiation was significantly improved by addition of CCC. In conclusion, simultaneous presence of HA and CCC contributed to the stem cell activity and epidermal differentiation in the reconstruction of SE. Legislation in the EU prohibits marketing cosmetics and personal care products that contain constituents that have been examined through animal experiments. To avoid these limitations, SEs can be used for testing the safety or the efficacy of cosmetic ingredients. Therefore, our results showed that combined use of HA and CCC can be helpful for the reconstruction of SE with good stem cell activity and epidermal differentiation. © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Bacteriological examination of inflamed epidermal cysts: a survey between 2008 and 2009 at a hospital in southern Taiwan

Directory of Open Access Journals (Sweden)

Yen-Hsi Liu

2010-09-01

Conclusions: Both aerobic and anaerobic microorganisms were present in the inflamed epidermal cysts, although the anaerobic bacteria, specifically, Propionibacterium spp and Peptostreptococcus spp, were isolated slightly more frequently. Antibiotics directed against anaerobes may be considered in the treatment regimen for inflamed epidermal cysts.

Electroplating and stripping copper on molybdenum and niobium

Science.gov (United States)

Power, J. L.

1978-01-01

Molybdenum and niobium are often electroplated and subsequently stripped of copper. Since general standard plating techniques produce poor quality coatings, general procedures have been optimized and specified to give good results.

Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib.

Science.gov (United States)

Wiedmann, Marcus; Feisthammel, Jürgen; Blüthner, Thilo; Tannapfel, Andrea; Kamenz, Thomas; Kluge, Annett; Mössner, Joachim; Caca, Karel

2006-08-01

Aberrant activation of the epidermal growth factor receptor is frequently observed in neoplasia, notably in tumors of epithelial origin. Attempts to treat such tumors with epidermal growth factor receptor antagonists resulted in remarkable success in recent studies. Little is known, however, about the efficacy of this therapy in biliary tract cancer. Protein expression of epidermal growth factor receptor, ErbB-2, and vascular endothelial growth factor receptor-2 was assessed in seven human biliary tract cancer cell lines by immunoblotting. In addition, histological sections from 19 patients with extrahepatic cholangiocarcinoma were analyzed for epidermal growth factor receptor, ErbB-2 and vascular endothelial growth factor receptor-2 expression by immunohistochemistry. Moreover, we sequenced the cDNA products representing the entire epidermal growth factor receptor coding region of the seven cell lines, and searched for genomic epidermal growth factor receptor amplifications and polysomy by fluorescence in-situ hybridization. Cell growth inhibition by gefitinib erlotinib and NVP-AEE788 was studied in vitro by automated cell counting. In addition, the anti-tumoral effect of erlotinib and NVP-AEE788 was studied in a chimeric mouse model. The anti-tumoral drug mechanism in this model was assessed by MIB-1 antibody staining, terminal deoxynucleotidyl transfer-mediated dUTP nick end-labelling assay, von Willebrand factor staining, and immunoblotting for p-p42/44 (p-Erk1/2, p-MAPK) and p-AKT. Immunoblotting revealed expression of epidermal growth factor receptor, ErbB-2, and vascular endothelial growth factor receptor-2 in all biliary tract cancer cell lines. EGFR was detectable in six of 19 (32%) extrahepatic human cholangiocarcinoma tissue samples, ErbB-2 in 16 of 19 (84%), and vascular endothelial growth factor receptor-2 in nine of 19 (47%). Neither epidermal growth factor receptor mutations nor amplifications or polysomy were found in the seven biliary tract cancer

Skin mucus of Cyprinus carpio inhibits cyprinid herpesvirus 3 binding to epidermal cells

Directory of Open Access Journals (Sweden)

Raj Victor

2011-08-01

Full Text Available Abstract Cyprinid herpesvirus 3 (CyHV-3 is the aetiological agent of a mortal and highly contagious disease in common and koi carp. The skin is the major portal of entry of CyHV-3 in carp after immersion in water containing the virus. In the present study, we used in vivo bioluminescence imaging to investigate the effect of skin mucus removal and skin epidermis lesion on CyHV-3 entry. Physical treatments inducing removal of the mucus up to complete erosion of the epidermis were applied on a defined area of carp skin just before inoculation by immersion in infectious water. CyHV-3 entry in carp was drastically enhanced on the area of the skin where the mucus was removed with or without associated epidermal lesion. To investigate whether skin mucus inhibits CyHV-3 binding to epidermal cells, tail fins with an intact mucus layer or without mucus were inoculated ex vivo. While electron microscopy examination revealed numerous viral particles bound on the fins inoculated after mucus removal, no particle could be detected after infection of mucus-covered fins. Finally, anti-CyHV-3 neutralising activity of mucus extract was tested in vitro. Incubation of CyHV-3 with mucus extract reduced its infectivity in a dose dependent manner. The present study demonstrates that skin mucus removal and epidermal lesions enhance CyHV-3 entry in carp. It highlights the role of fish skin mucus as an innate immune protection against viral epidermal entry.

Skin mucus of Cyprinus carpio inhibits cyprinid herpesvirus 3 binding to epidermal cells

Science.gov (United States)

2011-01-01

Cyprinid herpesvirus 3 (CyHV-3) is the aetiological agent of a mortal and highly contagious disease in common and koi carp. The skin is the major portal of entry of CyHV-3 in carp after immersion in water containing the virus. In the present study, we used in vivo bioluminescence imaging to investigate the effect of skin mucus removal and skin epidermis lesion on CyHV-3 entry. Physical treatments inducing removal of the mucus up to complete erosion of the epidermis were applied on a defined area of carp skin just before inoculation by immersion in infectious water. CyHV-3 entry in carp was drastically enhanced on the area of the skin where the mucus was removed with or without associated epidermal lesion. To investigate whether skin mucus inhibits CyHV-3 binding to epidermal cells, tail fins with an intact mucus layer or without mucus were inoculated ex vivo. While electron microscopy examination revealed numerous viral particles bound on the fins inoculated after mucus removal, no particle could be detected after infection of mucus-covered fins. Finally, anti-CyHV-3 neutralising activity of mucus extract was tested in vitro. Incubation of CyHV-3 with mucus extract reduced its infectivity in a dose dependent manner. The present study demonstrates that skin mucus removal and epidermal lesions enhance CyHV-3 entry in carp. It highlights the role of fish skin mucus as an innate immune protection against viral epidermal entry. PMID:21816061

Frozen allogeneic human epidermal cultured sheets for the cure of complicated leg ulcers.

Science.gov (United States)

Bolívar-Flores, Y J; Kuri-Harcuch, W

1999-08-01

Skin ulcers due to venous stasis or diabetes are common among the elderly and are difficult to treat. Repeated applications of cell-based products have been reported to result in cure or improvement of leg ulcers of small size in a fraction of patients. To examine the effects of frozen human allogeneic epidermal cultures for the treatment of acute and chronic ulcers. We treated a series of 10 consecutive patients with leg ulcers of different etiology and duration with frozen human allogeneic epidermal cultures stored frozen and thawed for 5-10 minutes at room temperature before application. Three patients had ulcers with exposed Achilles or extensor tendon. The ulcers treated were as large as 160 cm2 in area and of up to 20-years' duration. After preliminary preparation of the wounds by debridement to remove necrotic tissue and application of silver sulfadiazine to control infection, thawed cultures were applied biweekly from 2 to 15 times depending on the size and complexity of the ulcer. All ulcers healed, including those with tendon exposure. After the first few applications, granulation tissue formed in the ulcer bed and on exposed tendons, and epidermal healing took place through proliferation and migration of cells from the margins of the wound. The time required for complete healing ranged from 1 to 31 weeks after the first application. The use of frozen human allogeneic epidermal cultures is a safe and effective treatment for venous or diabetic ulcers, even those with tendon exposure. It seems possible that any leg ulcer will be amenable to successful treatment by this method.

Retinoic acid modulation of ultraviolet light-induced epidermal ornithine decarboxylase activity

International Nuclear Information System (INIS)

Lowe, N.J.; Breeding, J.

1982-01-01

Irradiation of skin with ultraviolet light of sunburn range (UVB) leads to a large and rapid induction of the polyamine biosynthetic enzyme ornithine decarboxylase in the epidermis. Induction of epidermal ornithine decarboxylase also occurs following application of the tumor promoting agent 12-0-tetradecanoylphorbol-13 acetate and topical retinoic acid is able to block both this ornithine decarboxylase induction and skin tumor promotion. In the studies described below, topical application of retinoic acid to hairless mouse skin leads to a significant inhibition of UVB-induced epidermal ornithine decarboxylase activity. The degree of this inhibition was dependent on the dose, timing, and frequency of the application of retinoic acid. To show significant inhibition of UVB-induced ornithine decarboxylase the retinoic acid had to be applied within 5 hr of UVB irradiation. If retinoic acid treatment was delayed beyond 7 hr following UVB, then no inhibition of UVB-induced ornithine decarboxylase was observed. The quantities of retinoic acid used (1.7 nmol and 3.4 nmol) have been shown effective at inhibiting 12-0-tetradecanoyl phorbol-13 acetate induced ornithine decarboxylase. The results show that these concentrations of topical retinoic acid applied either before or immediately following UVB irradiation reduces the UVB induction of epidermal ornithine decarboxylase. The effect of retinoic acid in these regimens on UVB-induced skin carcinogenesis is currently under study

Bioengineering a human plasma-based epidermal substitute with efficient grafting capacity and high content in clonogenic cells.

Science.gov (United States)

Alexaline, Maia M; Trouillas, Marina; Nivet, Muriel; Bourreau, Emilie; Leclerc, Thomas; Duhamel, Patrick; Martin, Michele T; Doucet, Christelle; Fortunel, Nicolas O; Lataillade, Jean-Jacques

2015-06-01

Cultured epithelial autografts (CEAs) produced from a small, healthy skin biopsy represent a lifesaving surgical technique in cases of full-thickness skin burn covering >50% of total body surface area. CEAs also present numerous drawbacks, among them the use of animal proteins and cells, the high fragility of keratinocyte sheets, and the immaturity of the dermal-epidermal junction, leading to heavy cosmetic and functional sequelae. To overcome these weaknesses, we developed a human plasma-based epidermal substitute (hPBES) for epidermal coverage in cases of massive burn, as an alternative to traditional CEA, and set up critical quality controls for preclinical and clinical studies. In this study, phenotypical analyses in conjunction with functional assays (clonal analysis, long-term culture, or in vivo graft) showed that our new substitute fulfills the biological requirements for epidermal regeneration. hPBES keratinocytes showed high potential for cell proliferation and subsequent differentiation similar to healthy skin compared with a well-known reference material, as ascertained by a combination of quality controls. This work highlights the importance of integrating relevant multiparameter quality controls into the bioengineering of new skin substitutes before they reach clinical development. This work involves the development of a new bioengineered epidermal substitute with pertinent functional quality controls. The novelty of this work is based on this quality approach. ©AlphaMed Press.

Fabrication and properties of strip casting 4.5 wt% Si steel thin sheet

Energy Technology Data Exchange (ETDEWEB)

Zu, Guoqing, E-mail: gz854@uowmail.edu.au [State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819 (China); School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, NSW 2522 (Australia); Zhang, Xiaoming [State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819 (China); Zhao, Jingwei [School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, NSW 2522 (Australia); Wang, Yuqian [State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819 (China); Yan, Yi [School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, NSW 2522 (Australia); Li, Chengang; Cao, Guangming [State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819 (China); Jiang, Zhengyi [School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, NSW 2522 (Australia)

2017-02-15

Three 4.5 wt% Si steel thin sheets with different thicknesses were efficiently fabricated by twin-roll strip casting, warm rolling and cold rolling followed by final annealing. A comprehensive investigation from the workability of the as-cast strip to the magnetic property of the produces was performed to illustrate the superiority of the new materials. The results show that the as-cast strip, which has a much lower Vickers hardness than that of the 6.5 wt% Si steel, is suitable for rolling processing. The X-ray diffraction (XRD) and transmission electron microscopy (TEM) studies confirm that no ordering phase exists in the as-cast strip. The cold-rolled thin sheets exhibit good surface quality without edge cracks. Furthermore, all the three 4.5 wt% Si steel thin sheets possess relative strong <100>//ND texture and present high magnetic inductions and low iron losses after finial annealing. - Highlights: • 4.5 wt% Si as-cast sheet with excellent workability was produced by strip casting. • Three 4.5 wt% Si thin sheets were effectively fabricated by warm and cold rolling. • The microstructure and macro-texture of the thin sheets were elucidated. • High magnetic inductions and low iron losses were achieved simultaneously.

Position calibration of silicon strip detector using quasi-elastic scattering of 16O+197Au

International Nuclear Information System (INIS)

Yan Wenqi; Hu Hailong; Zhang Gaolong

2013-01-01

Background: Elastic scattering is induced by weakly unstable nuclei. Generally, a good angular resolution for angular distribution of elastic scattering is needed. The silicon strip detector is often used for this kind of experiment. Purpose: In order to use silicon strip detector to study the elastic scattering of weakly unbound nuclei, it is important to get the information of its position calibration. It is well known that the elastic scattering of stable nuclei has a good angular distribution and many experimental data have been obtained. Methods: So the scattering of stable nuclei can be used to calibrate the position information of silicon strip detector. In this experiment, the positions of silicon strip detectors are calibrated using 101 MeV and 59 MeV 16 O scattering on the 197 Au target. Results: The quasi-elastic peaks can be observed in the silicon strip detectors and the counts of quasi-elastic 16 O can be obtained. The solid angles of the silicon strip detectors are calibrated by using alpha source which has three alpha energy values. The angular distribution of quasi-elastic scattering of 16 O+ 197 Au is obtained at these two energy values. Conclusions: The experimental data of angular distribution are reasonable and fit for the principle of angular distribution of elastic scattering. It is concluded that in the experiment these silicon strip detectors can accurately give the position information and can be used for the elastic scattering experiment. (authors)

USE OF MEMBRANE EMULSION SPAN 80 AND TOPO IN URANIUM EXTRACTION AND STRIPPING

Directory of Open Access Journals (Sweden)

Kris Tri Basuki

2017-01-01

Full Text Available ABSTRACT USE OF MEMBRANE EMULSION SPAN 80 AND TOPO IN URANIUM EXTRACTION AND STRIPPING. Membrane emulsion span 80 and TOPO used in uranium extraction and stripping has been done. The extraction was carried outby emulsion membrane H3PO4 in TOPO-Kerosene. The feed or external aqueous phase was uranium in  HNO3. The emulgator span-80 was used to obtain a stable emulsion membrane system. The influence factors were percentage of TOPO-Kerosene, time extraction,  molarity of external aqueous phase and  molarity of internal aqueous. After the emulsion membrane was formed, the extractionand stripping process was performed. The ratio volume feed : volume membrane phase equal to 1 : 1 and volume of 5 % TOPO-Kerosene : Volume 3 M H3PO4 equal 1 : 1 were used. The relative good yield were obtained at concentration of TOPO in Kerosene and 3 M H3PO4 was 5 %, molarity of internal aqueous phase equal to 1 M, molarity of external aqueous phase 3 M H3PO4 and time extraction equalto 10 minutes with the speed of emulsification was 8000 rpm. At this condition the extraction efficiency of uranium obtained was 97.8 %, the stripping efficiency 52.56 %, and the total efficiency was 53.80 %. Keywords: membrane emulsion, extraction, stripping, span 80, kerosene, uranium. ABSTRAK PENGGUNAAN MEMBRAN EMULSI SPAN 80 DAN TOPO UNTUK EKSTRASI DAN STRIPPING URANIUM. Telah dilakukan penelitian membran emulsi span 80 dan TOPO yang digunakan untuk ekstraksi uranium. Extraksi dengan membran emulsi H3PO4 dalam TOPO-Kerosen. Larutan umpan untuk fasa air eksternal adalah uranium dalam asam nitrat. Untuk memperoleh sistem emulsi yang stabil dipakai emulgator Span 80. Parameter yang berpengaruh adalah persen TOPO-Kerosene, molaritas fasa air internal H3PO4, molaritas fasa air eksternal HNO3 dan waktu ekstraksi. Setelah diperoleh membran emulsi, kemudian dilakukan proses ekstraksi dan stripping, dengan rasio volume umpan : volume membran sebesar 1 : 1; volume 5% TOPO-Kerose : volume 3M

Paper Strip-based Fluorometric Determination of Cyanide with an Internal Reference

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong-Nam; Hong, Jong-In [Seoul National University, Seoul (Korea, Republic of); Seo, Hyejin; Shin, Ik-Soo [Soongsil University, Seoul (Korea, Republic of)

2016-08-15

The rapid, selective, and sensitive determination of cyanide anion (CN{sup -}) using a simple paper strip is highly attractive because cyanide is acutely lethal to living organisms via all routes of administration, including alcohol consumption and inhaling cigarette smoke. Here, a synthetic probe (1) was designed for the selective determination of cyanide. The probe displays rapid and large blue spectral change (Δλ{sub abs}=148 nm, Δλ{sub em}= 165 nm) with respect to target recognition. Probe 1 exhibits a strong push-pull electronic effect and comprises a dimethylaminoaryl group as a donor and malononitrile as an acceptor; the π-conjugation system can be destroyed by the Michael-type addition of cyanide at the electrophilic β-positions of the nitrile groups, resulting in the marked emergence of a peak at λ{sub em}= 515 nm. The developed probe was successfully applied to a paper test strip because of its noticeable optical changes upon reaction with cyanide. The fabricated dumbbell-shaped paper strip with an internal reference allowed the cyanide detection, which is indispensable for quantitative analysis in point-of-care testing. The paper strip test showed selective response to cyanide, with a linear correlation in the range of 0-25 mM in a simple and cost-effective manner.

Paper Strip-based Fluorometric Determination of Cyanide with an Internal Reference

International Nuclear Information System (INIS)

Lee, Dong-Nam; Hong, Jong-In; Seo, Hyejin; Shin, Ik-Soo

2016-01-01

The rapid, selective, and sensitive determination of cyanide anion (CN"-) using a simple paper strip is highly attractive because cyanide is acutely lethal to living organisms via all routes of administration, including alcohol consumption and inhaling cigarette smoke. Here, a synthetic probe (1) was designed for the selective determination of cyanide. The probe displays rapid and large blue spectral change (Δλ_a_b_s=148 nm, Δλ_e_m= 165 nm) with respect to target recognition. Probe 1 exhibits a strong push-pull electronic effect and comprises a dimethylaminoaryl group as a donor and malononitrile as an acceptor; the π-conjugation system can be destroyed by the Michael-type addition of cyanide at the electrophilic β-positions of the nitrile groups, resulting in the marked emergence of a peak at λ_e_m= 515 nm. The developed probe was successfully applied to a paper test strip because of its noticeable optical changes upon reaction with cyanide. The fabricated dumbbell-shaped paper strip with an internal reference allowed the cyanide detection, which is indispensable for quantitative analysis in point-of-care testing. The paper strip test showed selective response to cyanide, with a linear correlation in the range of 0-25 mM in a simple and cost-effective manner.

Can Whitening Strips interfere with the Bond Strength of Composite Resins?

Science.gov (United States)

Firoozmand, Leily Macedo; Reis, Washington Luís Machado dos; Vieira, Mercêdes Aroucha; Nunes, Adriana Gomes; Tavarez, Rudys Rodolfo de Jesus; Tonetto, Mateus Rodrigues; Bramante, Fausto Silva; Bhandi, Shilpa H; Roma, Regina Vieira de Oliveira; Bandeca, Matheus Coelho

2015-04-01

The aim of this study was to investigate in vitro the bond strength of composite resins on enamel previously treated with whitening strips. A total of 48 bovine incisors were allocated to four experimental groups (n = 12 each): G1 (WSC)- treated with 9.5% hydrogen peroxide whitening strips (3D White Whitestrips® Advanced Vivid/CREST); G2 (WSO)-treated with 10% hydrogen peroxide whitening strips (3D WhiteTM/Oral B); G3 (WG)-treated with 7.5% hydrogen peroxide gel with fluorine, calcium and potassium nitrate (White Class®/FGM); and G4 (C)-control not subjected to bleaching treatment. The specimens were subjected to bleaching over 2 weeks following the manufacturers' instructions. Following the elaboration of the composite resin test specimens, the samples were stored in artificial saliva and subsequently subjected to the micro-shear test using the universal testing machine (EMIC®). The bond strength values were analyzed by one-way ANOVA and Tukey's statistical test (5%). Significant differences were observed among the investigated groups (p enamel-resin interface. The bond strength decreased following 14 days of treatment with bleaching strips, whereas the whitening gel with 7.5% hydrogen peroxide, calcium and fluorine increased the bond strength.

[Comparative measurement of urine specific gravity: reagent strips, refractometry and hydrometry].

Science.gov (United States)

Costa, Christian Elías; Bettendorff, Carolina; Bupo, Sol; Ayuso, Sandra; Vallejo, Graciela

2010-06-01

The urine specific gravity is commonly used in clinical practice to measure the renal concentration/dilution ability. Measurement can be performed by three methods: hydrometry, refractometry and reagent strips. To assess the accuracy of different methods to measure urine specific gravity. We analyzed 156 consecutive urine samples of pediatric patients during April and May 2007. Urine specific gravity was measured by hydrometry (UD), refractometry (RE) and reagent strips (TR), simultaneously. Urine osmolarity was considered as the gold standard and was measured by freezing point depression. Correlation between different methods was calculated by simple linear regression. A positive and acceptable correlation was found with osmolarity for the RE as for the UD (r= 0.81 and r= 0.86, respectively). The reagent strips presented low correlation (r= 0.46). Also, we found good correlation between measurements obtained by UD and RE (r= 0.89). Measurements obtained by TR, however, had bad correlation when compared to UD (r= 0.46). Higher values of specific gravity were observed when measured with RE with respect to UD. Reagent strips are not reliable for measuring urine specific gravity and should not be used as an usual test. However, hydrometry and refractometry are acceptable alternatives for measuring urine specific gravity, as long as the same method is used for follow-up.