Csaba Horváth and preparative liquid chromatography.

Science.gov (United States)

Guiochon, Georges

2005-06-24

Few chromatographers have been interested in furthering preparative liquid chromatography. The pioneers, Tswett, Kuhn and Lederer, A.J.P. Martin, Tiselius, isolated fractions but as an intermediate step in the analysis of their samples. The progress in electronics and sensors, and in their miniaturization has lead to the paradoxical situation that the analysts never see the transient pure fractions that their detector quantitates. Yet, over the last 25 years, preparative liquid chromatography has become an important industrial process for the separation, the extraction, and/or the purification of many pharmaceuticals or pharmaceutical intermediates, including pure enantiomers, purified peptides and proteins, compounds that are manufactured at the relatively large industrial scale of a few kilograms to several hundred tons per year. This development that has strongly affected the modem pharmaceutical industry is mainly due to the pioneering work of Csaba Horváth. His work in preparative HPLC was critical at both the practical and the theoretical levels. He was the first scientist in modem times to pay serious attention to the relationships between the curvature of the equilibrium isotherms, the competitive nature of nonlinear isotherms, and the chromatographic band profiles of complex mixtures. The thermodynamics of multi-component phase equilibria and mass transfer kinetics in chromatography attracted his interest and were the focus of ground-breaking contributions. He investigated displacement chromatography, an old method invented by Tiselius that Csaba was first to implement in HPLC. This choice was explained by the essential characteristic of displacement chromatography, in that it delivers fractions that can be far more concentrated than the feed. Remarkably, once the basics of nonlinear chromatography had been mastered in his group, most of the applications that were studied by his coworkers dealt with peptides of various sizes and with proteins. Thus, all

Playing with particles

CERN Multimedia

Katarina Anthony

2011-01-01

Could the principles of particle physics ever be explained by a game? Could a deck of cards ever teach the Standard Model the way Monopoly teaches economics? According to players of the Quark Matter card game, the answer is an easy “yes!”.   Csaba Török and Judit Csörgő (second and third from left) at the award ceremony for the Eötvös University Innovation Contest. When he was only 17 years old, Hungarian student Csaba Török came up with the idea for the Quark Matter cards. “I wanted people to think of the Standard Model as fun – not just a serious, scientific theory,” says Csaba. “The cards can turn everyone into a pseudo-physicist.” He shared the idea with his friend Judit Csörgő and her physicist father, Tamás Csörgő, and together they went on to develop Quark Matter into the game it is today. Csaba and Judit were both members o...

Euroopal on kaks põllumajanduspoliitikat / Annika Poldre

Index Scriptorium Estoniae

Poldre, Annika

2005-01-01

Euroopa Parlamendi põllumajandus- ja maaelu arengu komiteesse kuuluvad sotsiaaldemokraadid Csaba Sandor Tabajdi Ungarist, Bogdan Golik Poolast ning Luis Manuel Capoulas Santos Portugalist peavad Euroopa Liidu põllumajanduspoliitikat liiga liberaalseks

Krugovrashtshenije pobegov v prirode / Nikolai Hrustaljov

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Hrustaljov, Nikolai

2008-01-01

Venemaal, Ivanovski oblastis Jurjevetsi toimus teine Andrei Tarkovskile pühendatud filmifestival "Peegel" ("Zerkalo"). Pikemalt Hiner Saleemi filmist "Pariisi katuste all" ("Sous les toits de Paris") : Prantsusmaa 2007 ja Csaba Bolloki filmist "Iska teekond" ("Iszka utazasa") : Ungari 2007. Ka teistest auhinnavõitjatest

Distributed Simulation in Industry

NARCIS (Netherlands)

C.A. Boer (Csaba)

2005-01-01

textabstractCsaba Attila Boer was born in Satu Mare, Romania, on 29 October, 1975. He completed his secondary education at Kölcsey Ferenc High School, in Satu Mare, in 1994. In the same year he started his higher education at Babeş-Bolyai University, Faculty of Mathematics and Computer Science,

[Raamat] / Kalmer Mäeorg

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Mäeorg, Kalmer

2008-01-01

Rets. rmt.: Tallinna kodanikeraamat 1786-1796 = Das Revaler Bürgerbuch 1786-1796. Koost. Csaba Janos Kenéz. Tallinn : Tallinna Linnaarhiiv, 2006. (Tallina Linnaarhiivi Toimetised ; 9). Käsitletud ajajärk on tuntud asehalduskorra ajana. Katariina II reformid muutsid põhjalikult Tallinna valitsemiskorda. Tulemuseks oli kodanikkonna mitmekordistumine ning selle rahvusliku ja sotsiaalse koosseisu mitmekesistumine

Islandil peeti filmipidu Kuldse Lunni säras / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2007-01-01

Muljeid Islandilt, Reykjaviki 4. rahvusvaheliselt filmifestivalilt, mis toimus 27. septembrist 7. oktoobrini s.a. Peauhinna sai ungarlase Csaba Bolloki "Iska reis" ("Iszka utazasa"). Publiku auhinna sai Anton Corbijni "Kontroll", FIPRESCI auhinna sai taanlase Peter Schınau Fogi "Nutmise kunst". Ka iraanlase Fazli Bayrami filmist "Kas sul on veel õuna?" ja argentiinlanna Lucia Puenzo filmist "XXY"

Uudised : Võistlevad noored orkestrijuhid. Csaba Szilvay ansambel tulemas. Rootsi tattoo-orkester Tallinnas / Tiit Mesila

Index Scriptorium Estoniae

Mesila, Tiit, 1942-

2000-01-01

TPÜs toimub III noorte puhkpilliorkestrijuhtide konkurss. S. Szilvay tšello- ja kontrabassiansambel esineb 23. ja 24. apr. Tallinnas. Möödunud nädalavahetusel andis Tallinnas kontserte Rootsi kaitseväe orkester

Rural implications of food industry FDI in the Baltic countries in a CEE context / Csaba Jansik

Index Scriptorium Estoniae

Jansik Csaba

2003-01-01

Välisinvestorid on omandanud olulise osa Balti riikide toiduainetetööstusest. See on kaasa toonud kaasaegse juhtimise, töötlemise, turustuse ja logistika, pidevalt on paranenud toiduainete kvaliteet ja sortiment. Tabelid

Rencontres de Moriond EW 2012: Addressing symmetry breaking and mass hierarchy

CERN Multimedia

Pauline Gagnon

2012-01-01

Last Friday at the Moriond conference in La Thuile in Italy, Lisa Randall from Harvard University reminded the audience how all fields are related: electroweak symmetry breaking must take into account flavour physics for example. Every good model should address this intrinsic connection.   Despite many expectations, no signs for supersymmetry (SUSY) of any type has been found to date. So Lisa Randall worked with Csaba Csaki and John Terning to explore alternatives and developed a version of supersymmetry built on the Minimal Composite Supersymmetry Standard Model (MCSSM) that Csaki, Shirman, and Terning had developed, incorporating a strongly interacting theory with compositeness that addresses among other things the fact that the top quark is so much heavier than all other quarks. Randall and collaborators showed that this model, when supersymmetry is incorporated, naturally accommodates both a Higgs boson around 125 GeV and a light stop, the supersymmetric partner to the top quark. &a...

INTERNACIONALIZAÇÃO DE MARCAS DE LUXO BRASILEIRAS: UM ESTUDO DE CASO DA JOALHERIA H. STERN

Directory of Open Access Journals (Sweden)

José Coelho de Andrade Albino

2009-01-01

Full Text Available Este estudo analisa os desafios que envolvem a gestão de marcas globais que atuam no campodo luxo, principalmente aquelas com origem em países do terceiro mundo como o Brasil. Paraa realização da pesquisa, adotou-se como estratégia metodológica o estudo de caso único,tendo-se como objeto empírico a joalheria H. Stern. O estudo se baseia em pesquisasbibliográficas; entrevistas em profundidade com os dirigentes da empresa; visitas técnicas àsua sede e principais lojas, pesquisa documental e análise de discurso das campanhasnacionais e internacionais da marca e dos seus principais concorrentes. Concluiu-se, ao finalda pesquisa, que a empresa seguiu os pressupostos da Escola de Uppsala ao promover suainternacionalização, assim como se encontra em fase de transição entre a primeira e segundacorrente do branding, conforme classificação proposta por Schultz, Antorini e Csaba (2005.Já com relação ao modelo de gestão de marcas de luxo desenvolvido por Beverland (2004,pode-se afirmar que a H. Stern gerencia, de forma consistente e integrada, sua marca emcontexto global.

The prediction of candidate genes for cervix related cancer through gene ontology and graph theoretical approach.

Science.gov (United States)

Hindumathi, V; Kranthi, T; Rao, S B; Manimaran, P

2014-06-01

With rapidly changing technology, prediction of candidate genes has become an indispensable task in recent years mainly in the field of biological research. The empirical methods for candidate gene prioritization that succors to explore the potential pathway between genetic determinants and complex diseases are highly cumbersome and labor intensive. In such a scenario predicting potential targets for a disease state through in silico approaches are of researcher's interest. The prodigious availability of protein interaction data coupled with gene annotation renders an ease in the accurate determination of disease specific candidate genes. In our work we have prioritized the cervix related cancer candidate genes by employing Csaba Ortutay and his co-workers approach of identifying the candidate genes through graph theoretical centrality measures and gene ontology. With the advantage of the human protein interaction data, cervical cancer gene sets and the ontological terms, we were able to predict 15 novel candidates for cervical carcinogenesis. The disease relevance of the anticipated candidate genes was corroborated through a literature survey. Also the presence of the drugs for these candidates was detected through Therapeutic Target Database (TTD) and DrugMap Central (DMC) which affirms that they may be endowed as potential drug targets for cervical cancer.

A novel histological technique for distinguishing between epithelial cells in forensic casework.

Science.gov (United States)

French, Claire E V; Jensen, Cynthia G; Vintiner, Susan K; Elliot, Douglas A; McGlashan, Susan R

2008-06-10

There are a number of forensic cases in which the identification of the epithelial cell type from which DNA originated would provide important probative evidence. This study aimed to develop a technique using histological staining of fixed cells to distinguish between skin, buccal and vaginal epithelium. First, 11 different stains were screened on formalin-fixed, wax-embedded cells from five women. Samples were analysed qualitatively by examining staining patterns (colour) and morphology (absence or presence of nuclei). Three of the staining methods--Dane's, Csaba's and Ayoub-Shklar--were successful in distinguishing skin epithelial cells from buccal and vaginal. Second, cells were smeared directly onto slides, fixed with one of five fixatives and stained with one of the three stains mentioned above. Methanol fixation, coupled with the Dane's staining method, specific to keratin, was the only technique that distinguished between all three cell types. Skin cells stained magenta, red and orange and lacked nuclei; buccal cells stained predominantly orange-pink with red nuclei; while vaginal cells stained bright orange with orange nuclei and a blue extracellular hue. This staining pattern in vaginal cells was consistent in samples collected from 50 women aged between 18 and 67. Identification of cell type from unlabelled micrographs by 10 trained observers showed a mean success rate of 95%. The results of this study demonstrate that histological staining may provide forensic scientists with a technique for distinguishing between skin, buccal and vaginal epithelial cells and thus would enable more conclusive analyses when investigating sexual assault cases.

The Steins and the Hungarians

Directory of Open Access Journals (Sweden)

Barki, Gergely

2014-05-01

Full Text Available The traveling exhibition entitled "The Steins Collect" (2011-12 again drew attention – and on this occasion in a manner perhaps more vivid than any exhibition to date – to the importance of the systematically canon-shaping work that took place in two tiny Parisian ateliers (one in the Rue de Fleurus, the other in the Rue de Madame in terms of the new painterly movements that emerged at the beginning of the 20th century. Leo, Gertrude, and Michael, three siblings from the Stein family, a family of Jewish origin from San Francisco, along with Michael's wife Sarah, not only built within the space of a few years the most important contemporary art collection in Paris, but through their lively salons came to be the most influential shapers and propagators of universal modernism, making their influence felt to this day on assessments of avant-garde art. In the course of preparations for the exhibition and the publication of the accompanying catalogue, both of which provide a comprehensive survey of the Steins' activity, light was cast on the family's Hungarian connections as well. Consequently, one painting by the Hungarian Vilmos Pelrott-Csaba was included at the American venues (San Francisco and New York of the exhibition, and a presentation on the family's ties to Hungary was held at the scholarly conference organized in connection with the exhibition. Despite the fact that several essays have been published on this subject, the written sources have not been collected – neither those dealing with the large number of Hungarians present at the Steins' Saturday evening gatherings, nor those covering the Hungarian pupils at the Académie Matisse, which was closely aligned with the Steins. This essay is a revised version of the presentation held at the Metropolitan Museum of Art in New York, supplemented with additional source-material.

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

Directory of Open Access Journals (Sweden)

Papp C

2017-07-01

Full Text Available Csaba Papp,1 Krisztian Pak,2 Tamas Erdei,2 Bela Juhasz,2 Ildiko Seres,3 Anita Szentpéteri,3 Laszlo Kardos,4 Maria Szilasi,5 Rudolf Gesztelyi,2 Judit Zsuga1 1Department of Health Systems Management and Quality Management for Health Care, Faculty of Public Health, 2Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, 3Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4Department of Clinical Pharmacology, Infectious Diseases and Allergology, Kenezy Gyula Teaching County Hospital and Outpatient Clinic, 5Department of Pulmonology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Abstract: COPD is accompanied by limited physical activity, worse quality of life, and increased prevalence of depression. A possible link between COPD and depression may be irisin, a myokine, expression of which in the skeletal muscle and brain positively correlates with physical activity. Irisin enhances the synthesis of brain-derived neurotrophic factor (BDNF, a neurotrophin involved in reward-related processes. Thus, we hypothesized that mood disturbances accompanying COPD are reflected by the changes in the irisin–BDNF axis. Case history, routine laboratory parameters, serum irisin and BDNF levels, pulmonary function, and disease-specific quality of life, measured by St George’s Respiratory Questionnaire (SGRQ, were determined in a cohort of COPD patients (n=74. Simple and then multiple linear regression were used to evaluate the data. We found that mood disturbances are associated with lower serum irisin levels (SGRQ’s Impacts score and reciprocal of irisin showed a strong positive association; β: 419.97; 95% confidence interval [CI]: 204.31, 635.63; P<0.001. This association was even stronger among patients in the lower 50% of BDNF levels (β: 434.11; 95% CI: 166.17, 702.05; P=0.002, while it became weaker for patients in the higher 50% of BDNF concentrations (β: 373.49; 95% CI: -74.91, 821.88; P=0

Spin-Orbit Torque-Assisted Switching in Magnetic Insulator Thin Films with Perpendicular Magnetic Anisotropy

Science.gov (United States)

Wu, Mingzhong

As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque that can induce magnetization switching in a neighboring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than switching using conventional spin-transfer torque. This presentation reports the SOT-assisted switching in heavy metal/magnetic insulator systems.1 The experiments made use of Pt/BaFe12O19 bi-layered structures. Thanks to its strong spin-orbit coupling, Pt has been widely used to produce pure spin currents in previous studies. BaFe12O19 is an M-type barium hexagonal ferrite and is often referred as BaM. It is one of the few magnetic insulators with strong magneto-crystalline anisotropy and shows an effective uniaxial anisotropy field of about 17 kOe. It's found that the switching response in the BaM film strongly depends on the charge current applied to the Pt film. When a constant magnetic field is applied in the film plane, the charge current in the Pt film can switch the normal component of the magnetization (M⊥) in the BaM film between the up and down states. The current also dictates the up and down states of the remnant magnetization when the in-plane field is reduced to zero. When M⊥ is measured by sweeping an in-plane field, the response manifests itself as a hysteresis loop, which evolves in a completely opposite manner if the sign of the charge current is flipped. When the coercivity is measured by sweeping an out-of-plane field, its value can be reduced or increased by as much as about 500 Oe if an appropriate charge current is applied. 1. P. Li, T. Liu, H. Chang, A. Kalitsov, W. Zhang, G. Csaba, W. Li, D. Richardson, A. Demann, G. Rimal, H. Dey, J. S. Jiang, W. Porod, S. Field, J. Tang, M. C. Marconi, A. Hoffmann, O. Mryasov, and M. Wu, Nature Commun. 7:12688 doi: 10.1038/ncomms12688 (2016).

Image-based modeling of flow and reactive transport in porous media

Science.gov (United States)

Qin, Chao-Zhong; Hoang, Tuong; Verhoosel, Clemens V.; Harald van Brummelen, E.; Wijshoff, Herman M. A.

2017-04-01

Brummelen, and A. Reali (2016), Mixed Isogeometric Finite Cell Methods for the Stokes problem, Computer Methods in Applied Mechanics and Engineering, doi:10.1016/j.cma.2016.07.027. Scheibe, T. D., W. A. Perkins, M. C. Richmond, M. I. McKinley, P. D. J. Romero-Gomez, M. Oostrom, T. W. Wietsma, J. A. Serkowski, and J. M. Zachara (2015), Pore-scale and multiscale numerical simulation of flow and transport in a laboratory-scale column, Water Resources Research, 51(2), 1023-1035, doi:10.1002/2014WR015959. Verhoosel, C. V., G. J. van Zwieten, B. van Rietbergen, and R. de Borst (2015), Image-based goal-oriented adaptive isogeometric analysis with application to the micro-mechanical modeling of trabecular bone, Computer Methods in Applied Mechanics and Engineering, 284(February), 138-164, doi:10.1016/j.cma.2014.07.009.

The history of the Laboratory of Pathology of the Cluj-Napoca Oncological Institute.

Science.gov (United States)

Simu, G; Buiga, R

2006-01-01

depressed immunity in the advanced stages of cancer. In the same direction, the behavior of mast cells has been studied in collaboration with Professor George Csaba from the Budapest Medical University, Department of Biology. The observations brought about were remarked by the Canadian scientist Hans Selye. Most of these works have been included in the book "Immunity and cancer", distinguished with "Victor Babeş" Prize of the Romanian Academy. The arrival in the Institute of Professor Ion Macavei, disciple of Iuliu Hatieganu and founder of the Clinical Hematology in Cluj, expert in blood and bone marrow cytology, has given a strong impulse to the studies of malignant hemopoietic diseases. The current use of cytologic and histopathologic examinations in this field of pathology and, especially, the introduction by him, for the first time in Romania, of the osteomedullary biopsy has permitted the elaboration of an appreciated work about the cytologic and histologic diagnosis of lymphadenopathies. In the histochemical-histoenzymatic period of the microscopic diagnosis, between the years 1960-1990, the laboratory has enjoyed by the advices and the material help of Professor Raymond Wegmann from the Paris University, Institute of Histochemistry, the founder-editor of the International Review of Histochemistry, from 1976, of Cellular and Molecular Biology, who visited our laboratory in 1992. From 1965, in an adjacent Laboratory of Cytogenetics, Corneliu D. Olinici has performed the first karyotypes in Cluj and has teached the method to several other specialists. Despite the technical difficulties, the works performed in the Laboratory of Pathology have succeeded sometimes to reach the quality required by Professor Chiricută to a valuable scientific work in cancerology. This performance has been obtained by a study concerning Crabtree effect variations in tumoral metastases or about lactic-dehydrogenase behavior in breast carcinomas.

List of Participants

Science.gov (United States)

2011-08-01

Abigail Alvarez OlarteCINVESTAV Alba Leticia Carrillo MonteverdeDCI-UG Alberto CarramiñanaINAOE Aldo MorselliFERMI Alejandro CastillaDCI-UG Alejandro IbarraTechnical University of Munich Alma D Rojas PachecoFCFM-BUAP Alma Xochitl Gonzalez MoralesInstituto de Ciencias Nucleares, UNAM Andrew Walcott BeckwithAmerican Institute of Beam Energy Physics Ariadna Montiel ArenasDepartamento de Física, CINVESTAV Arnulfo ZepedaCinvestav Arturo Alvarez CruzInstituto de Fisica, UNAM Axel de la MacorraUNAM, IAC Azar MustafayevUniversity of Minnesota Benjamin JaramilloDCI-UG Vincent BertinCPPM-Marseille Carlos Alberto Vaquera-AraujoDCI-UG Carlos MuñozMadrid Autonoma U. & Madrid, IFT Carmine PagliaroneINFN, FNAL Carolina Lujan PeschardDCI-UG Christiane Frigerio MartinsUniversidade Federal do ABC-São Paulo Csaba BalazsMonash University David DelepineDCI-UG David G CerdenoUniversidad Autonoma de Madrid & Instituto de Fisica Teorica Debasish MajumdarSaha Institute of Nuclear Physics, Kolkata, India Dibyendu PanigrahiKandi Raj College, Kandi, Murshidabad, INDIA-742137 Dupret Alberto Santana BejaranoUniversidad de Sonora Departamento de Investigacion en Fisica Ernest MaRiverside U.C. Esteban Alejandro Reyes Pírez MontañezInstituto de Física, UNAM Federico Ortiz TrejoINSTITUTO DE ASTRONOMÍA - UNAM Francisco José de Anda NavarroUniversidad de Guadalajara González Alvarez Francisco JavierCINVESTAV-Depto. Física Gustavo Medina TancoICN-UNAM Hernando Efrain Caicedo OrtizInstituto Politecnico Nacional - IPN J D VergadosCERN & Ioannina U. James R BoyceJefferson Lab Jason SteffenFERMILAB Javier Montaño DomínguezDCI-UG Jeevan SolankiMandsaur Institue of Technology MP India Joe SatoSaitama University Jorge Luis Navarro EstradaUNAM-ICN and Universidad del Atlantico (B/quilla-Col.) Jose A R CembranosUniversity of Minnesota José DíazIFIC Jose Didino Garcia AguilarDepto. de Fisica. Cinvestav Keith OliveUniversity of Minnesota Konstantia BalasiUniversity of Ioannina, Greece Lilian Prado

Risk Assessment of Heavy Metals in Abandoned Mine Lands as Signifcant Contamination Problem in Romania

Science.gov (United States)

Horvath, E.; Jordan, G.; Fugedi, U.; Bartha, A.; Kuti, L.; Heltai, G.; Kalmar, J.; Waldmann, I.; Napradean, I.; Damian, G.

2009-04-01

careful and successive sampling design and a tiered assessment approach. Leaching tests are shown cost-efficient and informative methods for source (hazard) characterisation. REFERENCES Directive 2006/21/EC the European Parliament and of the Council on the management of waste from extractive industries and amending Directive 2004/35/EC. Commission of the European Communities, Brussels. Jordan G. and D'Alessandro M. (eds) (2004) Mining, Mining Waste and Related Environmental Issues: Problems and Solutions in the Central and Eastern European Candidate Countries. Joint Research Centre of the European Commission, Ispra. LB-NA-20868-EN-C. Jordan G., van Rompaey A., Szilassi P., Csillag G., Mannaerts C. and Woldai T. (2005) Historical land use changes and their impact on sediment fluxes in the Balaton basin (Hungary). Agriculture, Ecosystems and Environment, 108, 119-133. Jordan G., van Rompaey A., Somody A., Fügedi U., Bats M. and Farsang A. (2008) Spatial Modelling of Contamination in a Catchment Area Impacted by Mining: a Case Study for the Recsk Copper Mines, Hungary. Journal of Land Contamination and Reclamation (in press). Younger P.L., Banwart S.A., Hedin R.S. (2002) Mine water. Hydrology, pollution, remediation. Kluwer Academic Publishers, Dodrecht.