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Sample records for zhen-ye zhao ji-dong

  1. [The affinity between Le family of Tong Ren Tang and acu-moxibustion as viewed from Mian xue tang zhen jiu ji cheng (Mian Xuetang's Synthetic Work of Acu-moxibustion)].

    Science.gov (United States)

    Huang, L X

    2017-11-28

    This compilation process of Mian xue tang zhen jiu ji cheng ( Mian Xuetang ' s Synthetic Work of Acu - moxibustion )was quite mysterious, the book's advent coincidentally met with several major historical events which made its value of decoding its historical functions far beyond its academic value. The editor of this book is Le Xianyang, the founder of Tong Ren Tang. While compiling this book, he also made a replica of Ming-Dynasty's Zhengtong bronze statue. More than 200 years later, Le Jingyu, the 12th generation of the Le family revised Ming Tang Tu inherited from his ancestors and engraved Ming Tang Tu on the stone for its standardization. This great achievement of Le family was no less than the recasting of the Tiansheng bronze statue and the reengraving Tong ren shu xue zhen jiu tu jing ( Illustrated Manual of Acupuncture Points of the Bronze Figure ) by support of state power for building the Beijing Imperial Hospital in the eighth year of the Zhengtong reign (1443).

  2. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  3. Naiqin Zhao

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Naiqin Zhao. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 75-79. Microwave absorbing properties of activated carbon fibre polymer composites · Tianchun Zou Naiqin Zhao Chunsheng Shi Jiajun Li · More Details Abstract Fulltext PDF.

  4. Social Media Marketing Strategy for Zhen Meng Fitness Management Ltd in Shanghai

    OpenAIRE

    Sun, Mingwei

    2017-01-01

    The report is written based on practical training of marketing internship in Zhen Meng fitness management Ltd in Shanghai. With carrying out the research, setting objectives, setting and implementing a strategy, it is good to have a deeper understanding of social media marketing strategy. Secondly, with a SWOT analysis tool, it is defined the advantages and disadvantages of Zhen Meng fitness management Ltd in Shanghai. The report is going to try to make an example for other students or compan...

  5. The γ-gliadin-like γ-prolamin genes in the tribe Triticeae

    Indian Academy of Sciences (India)

    Supplementary data: The γ-gliadin-like γ-prolamin genes in the tribe Triticeae. Peng-Fei Qi, Cheng-Xing Le, Zhao Wang, Yu-Bin Liu, Qing Chen, Zhen-Zhen Wei, Bin-Jie Xu, Zheng-Yuan Wei,. Shou-Fen Dai, Yu-Ming Wei and You-Liang Zheng. J. Genet. 93, 35–41. Table 1. The γ-prolamin genes of diploid Triticeae species.

  6. Neuroprotective effect of Zhen Tian Wan on pial strip-induced ...

    African Journals Online (AJOL)

    ZTW significantly reduced the level of free radicals in pial stripped rats. ZTW can improve learning and memory function and it possess anti-oxidant activity. ZTW may be beneficial in the treatment of vascular dementia. Keywords: Zhen Tian Wan; pial strip; lesion; Memory; Morris water maze; free radicals ...

  7. [Research on the original plants of Xian Zhao Zi (Senshosi)].

    Science.gov (United States)

    Kotaka, Shuji

    2008-01-01

    Since the Heian period, Xian Zhao Zi (Senshosi) has been used as part of the ceremony believed to help in a healthy pregnancy and safe birth. The purpose of this report is to consider which plants are original Xian Zhao Zi plants. Past research lists certain plants as Xian Zhao Zi, but it was difficult to draw any conclusions.

  8. Explosive Nucleosynthesis in Different Ye Conditions

    International Nuclear Information System (INIS)

    Iwamoto, Nobuyuki; Umeda, Hideyuki; Nomoto, Ken'ichi; Tominaga, Nozomu; Thielemann, Friedrich-Karl; Hix, W. Raphael

    2006-01-01

    The influence of a large variation of Ye on explosive yield is investigated. We calculate nucleosynthesis with the initial electron fraction Ye ranging from 0.48 to 0.58 in explosive Si burning region in Population III, 25 M· supernovae. We obtain the significant overproduction of odd elements, K and Sc. In the Ye < 0.5 cases light p-process nuclei are enhanced. We find that the abundance pattern taken from arbitrary mixture of each nucleosynthesis yield in various values of Ye can reasonably explain that in observed extremely metal-poor stars

  9. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    Science.gov (United States)

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  10. Characterization and identification of in vitro metabolites of ...

    African Journals Online (AJOL)

    Characterization and identification of in vitro metabolites of (-)-epicatechin using ultra-high performance liquid chromatography-mass spectrometry. Rui Jun Cai, Xiao Ling Yin, Jing Liu, Da Xu Qin, Gui Zhen Zhao ...

  11. Developed feedback from the Swedish CDM and JI program; Utvecklad aaterrapportering fraan det svenska CDM- och JI-programmet

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    The Swedish Energy Agency is responsible for the Swedish government program for the Clean Development Mechanism (CDM) and Joint Implementation (JI). CDM and JI is the Kyoto Protocol's two project-based flexible mechanisms. This program focuses on participation in individual CDM- and JI-projects and on participation in multilateral CDM- and JI- funds. In the report the Swedish Energy Agency, on behalf of the Government, presents a proposal for developed reporting for the CDM- and JI-program. Furthermore, issues related to how CDM and JI can assist in meeting the Swedish climate objective by 2020 are discussed. Also, the role for potential new flexible mechanisms under UN Climate Convention is mentioned.

  12. Refinansieringsrisiko, DONG og Bankunionen

    DEFF Research Database (Denmark)

    Bechmann, Ken L.

    2014-01-01

    Denne leder indeholder primært redaktørens refleksioner og kommentarer i forlængelse af artiklerne om regulering af refinansieringsrisiko og om salget af aktier i DONG. Endvidere knyttes en række kommentarer til artiklen med Morningstars kritik af ”Om dygtighed, held og stjerner”, der blev bragt ...... Finans/Invest 1/14....

  13. Transforming traditional Tai Ji Quan techniques into integrative movement therapy-Tai Ji Quan: Moving for Better Balance.

    Science.gov (United States)

    Li, Fuzhong

    2014-03-01

    Tai Ji Quan, developed as a martial art, has traditionally served multiple purposes, including self-defense, competition/performance, and health promotion. With respect to health, the benefits historically and anecdotally associated with Tai Ji Quan are now being supported by scientific and clinical research, with mounting evidence indicating its potential value in preventing and managing various diseases and improving well-being and quality of life in middle-aged and older adults. The research findings produced to date have both public health significance and clinical relevance. However, because of its roots in the martial arts, transforming traditional Tai Ji Quan movements and training approaches into contemporary therapeutic programs and functional applications is needed to maximize its ultimate utility. This paper addresses this issue by introducing Tai Ji Quan: Moving for Better Balance , a functional therapy that involves the use of Tai Ji Quan principles and Yang-style-based movements to form an innovative, contemporary therapeutic approach that integrates motor, sensory, and cognitive components to improve postural control, gait, and mobility for older adults and those who have neurodegenerative movement impairments. It provides a synergy of traditional and contemporary Tai Ji Quan practice with the ultimate goal of improving balance and gait, enhancing performance of daily functional tasks, and reducing incidence of falls among older adults.

  14. Transforming traditional Tai Ji Quan techniques into integrative movement therapy—Tai Ji Quan: Moving for Better Balance

    Directory of Open Access Journals (Sweden)

    Fuzhong Li

    2014-03-01

    Full Text Available Tai Ji Quan, developed as a martial art, has traditionally served multiple purposes, including self-defense, competition/performance, and health promotion. With respect to health, the benefits historically and anecdotally associated with Tai Ji Quan are now being supported by scientific and clinical research, with mounting evidence indicating its potential value in preventing and managing various diseases and improving well-being and quality of life in middle-aged and older adults. The research findings produced to date have both public health significance and clinical relevance. However, because of its roots in the martial arts, transforming traditional Tai Ji Quan movements and training approaches into contemporary therapeutic programs and functional applications is needed to maximize its ultimate utility. This paper addresses this issue by introducing Tai Ji Quan: Moving for Better Balance, a functional therapy that involves the use of Tai Ji Quan principles and Yang-style-based movements to form an innovative, contemporary therapeutic approach that integrates motor, sensory, and cognitive components to improve postural control, gait, and mobility for older adults and those who have neurodegenerative movement impairments. It provides a synergy of traditional and contemporary Tai Ji Quan practice with the ultimate goal of improving balance and gait, enhancing performance of daily functional tasks, and reducing incidence of falls among older adults.

  15. Ethnobotany of dye plants in Dong communities of China.

    Science.gov (United States)

    Liu, Yujing; Ahmed, Selena; Liu, Bo; Guo, Zhiyong; Huang, Weijuan; Wu, Xianjin; Li, Shenghua; Zhou, Jiangju; Lei, Qiyi; Long, Chunlin

    2014-02-19

    Dyes derived from plants have an extensive history of use for coloring food and clothing in Dong communities and other indigenous areas in the uplands of China. In addition to use as coloring agents, Dong communities have historically utilized dye plants for their value for enhancing the nutritive, medicinal and preservative properties of foods. However, the persistence of plant-derived dyes and associated cultural practices and traditional knowledge is threatened with rapid socio-economic change in China. Research is needed to document the ethnobotany of dye plants in indigenous communities towards their conservation and potential commercialization as a sustainable means of supporting local development initiatives. Semi-structured surveys on plants used for coloring agents and associated traditional knowledge were conducted in fifteen Dong villages of Tongdao County in Hunan Province of South Central China during 2011-2012. Transect walks were carried out with key informants identified from semi-structured surveys to collect samples and voucher specimens for each documented plant species for taxonomic identification. Dong households at the study sites utilize the flowers, bark, stems, tubers and roots of 13 plant species from 9 families as dyes to color their customary clothing and food. Out of the documented plants, a total of 7 are used for coloring food, 3 for coloring clothing and 3 for both food and clothing. Documented plants consist of 3 species that yield black pigments, 3 for brownish red/russet pigments, 3 for red pigments, 2 for dark blue pigments and 2 for yellow pigments. In addition to dyes, the plants have multiple uses including medicinal, ornamental, sacrificial, edible, and for timber. The use of dyes derived from plants persists at the study sites for their important role in expressing Dong cultural identity through customary clothing and food. Further research is needed to evaluate the safety of dye plants, their efficacy in enhancing food

  16. A novel model for extending international co-operation in science and education

    NARCIS (Netherlands)

    de Boer, S.J.; Ji-zehn, Q.

    2004-01-01

    Journal of Zhejiang University SCIENCE (ISSN 1009-3095, Monthly) 2004 Vol. 5 No. 3 p.358-364 --------------------------------------------------------------------------------A novel model for extending international co-operation in science and educationDE BOER Sirp J.1, QIU Ji-zhen 2(1International

  17. Mechanisms of all-trans retinoic acid-induced differentiation of acute ...

    Indian Academy of Sciences (India)

    Author Affiliations. Ji-Wang Zhang1 Jian Gu1 Zhen-Yi Wang1 Sai-Juan Chen1 Zhu Chen1. Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Second Medical University, 197 Ruijin Road II, Shanghai 200025, People's Republic of China ...

  18. Study of Electromagnetic Wave Absorption Properties of Carbon Nanotubes-Based Composites

    Science.gov (United States)

    2012-11-29

    Publications: [1]. G. L. Zhao, Z. Ye, Z. Li, J. A. Roberts, "New carbon nanotube-epoxy composite for dampening microwave cavity resonance", IEEE Xplore ...Nanotechnology ( IEEE - NANO), 2012 12th IEEE Conference on 20-23 Aug. 2012. [2]. Z. Li, G. L. Zhao, P. Zhang, S. Guo, J. Tang, " Thermoelectric

  19. Lifting of a sector block for YE-2 at Kawasaki.

    CERN Multimedia

    R. Loveless/U. of Wisconsin

    2000-01-01

    YE-2 is build from machined sector blocks. Trial assembly is carried out horizontally. This picture represents the lifting of a machined sector block destined to the trial assembly of a half disk YE-2 at Kawasaki (KHI) Kobe, Japan.

  20. Zhao Tiancong——A MONUMENT TO ANTIMONY IN CHINA

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    Professor Zhao Tiancong is a famous specialist of our country in nonferrous merallurgy field and a doctoral teacher of Central South University of Technology. He has been devoting diligently his life to the development of the antimony metallurgy.

  1. [Professor YANG Zhao-min's contribution to the education of modern acupuncture and moxibustion].

    Science.gov (United States)

    Dong, Qin; Mu, Yan-Yun; Xia, You-Bing; Zhang, Jian-Bin

    2012-05-01

    It was completely collected and summarized the teaching history and the relevant historical materials of Professor YANG Zhao-min via consulting the literatures, investigation, interview, etc. in this paper. The summaries indicated that from the beginning of running a school, Professor YANG Zhao-min adhered to the CHENG's moral, worked hard and successfully explored and practiced the training pattern of teaching tour for the personnel training of acupuncture and moxibustion. He established the specialty of acupuncture and moxibustion, formatted courses and inherited the feature of practice teaching. He was in charge of the compilation of textbook and engaged in scientific innovation. He inherited the past and forged ahead into the future and had made the decision to cultivate the personnel of acupuncture and moxibustion. Professor YANG Zhao-min had practiced and developed the modern educational thought from the CHENG Dan-an and had made the important contribution to the training of acupuncture and moxibustion professionals.

  2. Multifactor Regulation of the MdtJI Polyamine Transporter in Shigella.

    Directory of Open Access Journals (Sweden)

    Adriano Leuzzi

    Full Text Available The polyamine profile of Shigella, the etiological agent of bacillary dysentery in humans, differs markedly from that of E. coli, its innocuous commensal ancestor. Pathoadaptive mutations such as the loss of cadaverine and the increase of spermidine favour the full expression of the virulent phenotype of Shigella. Spermidine levels affect the expression of the MdtJI complex, a recently identified efflux pump belonging to the small multi-drug resistance family of transporters. In the present study, we have addressed the regulation of the mdtJI operon in Shigella by asking which factors influence its expression as compared to E. coli. In particular, after identifying the mdtJI promoter by primer extension analysis, in vivo transcription assays and gel-retardation experiments were carried out to get insight on the silencing of mdtJI in E. coli. The results indicate that H-NS, a major nucleoid protein, plays a key role in repressing the mdtJI operon by direct binding to the regulatory region. In the Shigella background mdtJI expression is increased by the high levels of spermidine typically found in this microorganism and by VirF, the plasmid-encoded regulator of the Shigella virulence regulatory cascade. We also show that the expression of mdtJI is stimulated by bile components. Functional analyses reveal that MdtJI is able to promote the excretion of putrescine, the spermidine precursor. This leads us to consider the MdtJI complex as a possible safety valve allowing Shigella to maintain spermidine to a level optimally suited to survival within infected macrophages and, at the same time, prevent toxicity due to spermidine over-accumulation.

  3. How to Integrate Tai Ji Quan into Physical Education Programs

    Science.gov (United States)

    Lu, Chunlei

    2008-01-01

    Tai ji quan, also known as "tai chi," is an ancient Chinese exercise characterized by soft, slow, and meditative movements. It consists of a set of continuous, evenly paced, carefully choreographed, but natural, body shifts. "Tai ji" is an ancient Chinese philosophy, while "tai ji quan" refers to a type of physical activity based on tai ji…

  4. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Investigation of localization effect in GaN-rich InGaN alloys and modified band-tail model. Chuan-Zhen Zhao Bin Liu De-Yi Fu Hui Chen Ming Li Xiang-Qian Xiu Zi-Li Xie Shu-Lin Gu You-Dou Zheng. Volume 36 Issue 4 August 2013 pp 619-622 ...

  5. [Professor ZHAO Jiping's meridian diagnosis and treatment for primary dysmenorrhea].

    Science.gov (United States)

    Tan, Cheng; Zhang, Chang; Zhang, Jiajia; Wang, Jun

    2016-03-01

    For the treatment of primary dysmenorrhea, professor ZHAO Jiping focuses on meridian diagnosis and inspection, and uses pressing methods to locate the response points along the meridian, including acupoints and aishi points. During the stage of attack, it is essential to press along the spleen meridian, mainly Sanyinjiao (SP 6), Diji (SP 8) and Yinlingquan (SP 9); during the stage of remission, it is essential to press along the bladder meridian and stomach meridian, mainly Ganshu (BL 18), Pishu (BL 20), Weishu (BL 21), Shenshu (BL 23) and Zusanli (ST 36). The differences between deficiency syndrome and excess syndrome lead to the different feelings of doctors and patients. Combined with the results of meridian diagnosis and inspection, the aim of treatment can be achieved by different acupuncture methods. Professor ZHAO pays attention to the treatment of accompanied symptoms and timing of treatment, since the relief of accompanied syndromes and selection of timing are keys to relieving patient's pain.

  6. CDM and JI in View of the Sustainability Debate

    NARCIS (Netherlands)

    Schoot Uiterkamp, A.J.M.

    2001-01-01

    Clean Development Mechanism (CDM), Joint Implementation (JI) and emissions trading are the three flexible instruments incorporated in the Kyoto Protocol. This paper presents a critical assessment of the sustainability of energy-related technology innovation and transfer in the context of CDM and JI.

  7. ZHAO Jian-xiong (赵健雄)——A Famous Expert in Integrative Medicine and Dunhuang Medicine

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ ZHAO Jian-xiong, was born in Yulin City on November 1, 1942, Shaanxi Province. He graduated from Lanzhou Medical College in 1965, and practiced Western medicine after his graduation while learning traditional Chinese medicine (TCM). In 1980, Dr. ZHAO was one of the first students who graduated from the TCM graduate program at the China Academy of Traditional Chinese Medicine with a master's degree.

  8. Tai Ji Quan, the brain, and cognition in older adults

    Directory of Open Access Journals (Sweden)

    Yu-Kai Chang

    2014-03-01

    Full Text Available The relationship between physical activity (PA and cognition has received much attention recently. While evidence of improved cognition following PA has consistently been observed, the majority of studies have spotlighted aerobic exercise and the effects of other modes of PA, such as Tai Ji Quan, on cognition have received limited attention. This article provides a brief review of the literature concerning the influence of Tai Ji Quan on cognition in older adults, including those with intact cognition and those with cognitive impairment. In addition, this review proposes potential mechanisms (cardiovascular fitness, motor fitness, movement coordination, social interaction, and meditation statuses as well brain structure and function evaluated from a neuroimaging perspective that may explain the Tai Ji Quan–cognition relationship. Finally, we present suggestions for future research. In conclusion, Tai Ji Quan, with its multi-faceted characteristics, shows promise as a mode of PA for enhancing cognition, as well as brain health, in older adults. Based on the findings in this review, further exploration of the effects of Tai Ji Quan on cognition in older adults is warranted.

  9. Lõuna-Korea õpetab ettevaatlikkust / Dong Hyeon ; intervjueerinud Ave-Lii Idavain

    Index Scriptorium Estoniae

    Hyeon, Dong

    2015-01-01

    Vestlus Lõuna-Korea Pusani riikliku ülikooli majandusprofessori ja Tartu Ülikooli külalisprofessori Dong Hyeon Jung'iga Lõuna-Korea majanduslikust ja poliitilisest olukorrast. Emeriitprofessor oli kaks kuud TTÜ külalisõppejõud

  10. International Conference on Organometallic Chemistry (13th) Held in Torino, Europe on 4-9 September 1988. Abstracts

    Science.gov (United States)

    1988-09-09

    190, 8057 ZUrich, Switzerland Joseph Edwin and William E.Geiger, Department of Chemistry, University of Vermont, Burlington, Vermont, 05405 Arnold L...On Synthesis Of Dialkyl d-Trimethylsilyloxyalkylphosphonates Zhao Yong-Zhen and Li Zhong- Rua Dpartment o chemistry, Hua Zhong Normal University, Wuhan...Jose Vicente. Jose-AntelC hAd. Na-Yeij~xa Qhicote. Ju~an-Francisco Gutliez-Jugo. Carmen Ramirez do Arel lano. Departamento do Oulmica InordanIca

  11. Annual Report 2011 for the Swedish CDM and JI program; Aarsredovisning 2011 foer Sveriges CDM och JI-program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    The report is an annual report of the Swedish CDM [Clean Development Mechanism] and JI [Joint Implementation]program for 2011. The report shows aims and goals of the business and the work of individual CDM and JI projects and multilateral funds which have been performed over the entire duration of life and especially during 2011. The report presents volume orders, deliveries of emission reduction units as well as the volumes expected to be needed for the fulfillment of the national target by 2020. The report also includes information about the average price for the emission reductions as well as alternative costs.

  12. International Journal of Engineering, Science and Technology - Vol ...

    African Journals Online (AJOL)

    electrolysis pretreatment · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Shuchuan Peng, Lili Zhao, Xixi Liu, Dong Chen. http://dx.doi.org/10.4314/ijest.v2i7.63748 ...

  13. [Effects of long-term Tai Ji Quan exercise on automatic nervous modulation in the elderly].

    Science.gov (United States)

    Guo, Feng

    2015-03-01

    To examine the effects of long-term Tai Ji Quan (Chinnese Traditional Exercise) on automatic nervous modulation in the elders. The 18 subjects from Tai Ji Quan exercise class in Liaoning University of Retired Veteran Cadres were assigned into long-term Tai Ji Quan exercise group including 10 subjects and novice group including 8 subjects. Electrocardiography, respiratory and blood pressure data were collected on the following time points: at rest before Tai Ji Qhuan exercise and 30 min or 60 min after Tai Ji Quan exercise. The subjects at rest state in the long-term Tai Ji Quan exercise group showed higher than the subjects in the novice group in resperitory rate (RR), standard deviations of normal to normal intervals (SDNN), total power (TP), low frequency power (LFP), high frequency power (HFP), normalized high frequency power (nHFP), but lower in LFP/HFP, systolic and diastolic blood pressure, and heart rate. At rest state the respiratory rate of subjects in long-term Tai Ji Quan exercise group was significantly lower than the novices. After Tai Ji Quan exercise, TP, nHFP, LFP/HFP, heart rate and systolic pressure showed significantly changes, and the change level of Tai Ji Quan on these indices was larger in Tai Ji Quan exercise group than that in the novice group. Long-term Tai Ji Quan exercise can improve vagal modulations, and tend to reduce the sympathetic modulations.

  14. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Jiandong Wu1 Xiaolei Jin1 Yang Zhao1 Qing Dong1 Haiyang Jiang1 Qing Ma1. Key Laboratory of Crop Biology of Anhui Province, School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China ...

  15. Evolution of the defensin-like gene family in grass genomes

    Indian Academy of Sciences (India)

    . Jiandong Wu, Xiaolei Jing, Yang Zhao, Qing Dong, Haiyang Jiang and Qing Ma. J. Genet. 95, 53–62. Table 1. Information about DEFL genes in B. distachyon, O. sativa, S. bicolor and Z. mays. Species. Gene name. Gene identifer. ORF (aa).

  16. Detecting Long-term Trend of Water Quality Indices of Dong-gang River, Taiwan Using Quantile Regression

    Science.gov (United States)

    Yang, D.; Shiau, J.

    2013-12-01

    ABSTRACT BODY: Abstract Surface water quality is an essential issue in water-supply for human uses and sustaining healthy ecosystem of rivers. However, water quality of rivers is easily influenced by anthropogenic activities such as urban development and wastewater disposal. Long-term monitoring of water quality can assess whether water quality of rivers deteriorates or not. Taiwan is a population-dense area and heavily depends on surface water for domestic, industrial, and agricultural uses. Dong-gang River is one of major resources in southern Taiwan for agricultural requirements. The water-quality data of four monitoring stations of the Dong-gang River for the period of 2000-2012 are selected for trend analysis. The parameters used to characterize water quality of rivers include biochemical oxygen demand (BOD), dissolved oxygen (DO), suspended solids (SS), and ammonia nitrogen (NH3-N). These four water-quality parameters are integrated into an index called river pollution index (RPI) to indicate the pollution level of rivers. Although widely used non-parametric Mann-Kendall test and linear regression exhibit computational efficiency to identify trends of water-quality indices, limitations of such approaches include sensitive to outliers and estimations of conditional mean only. Quantile regression, capable of identifying changes over time of any percentile values, is employed in this study to detect long-term trend of water-quality indices for the Dong-gang River located in southern Taiwan. The results show that Dong-gang River 4 stations from 2000 to 2012 monthly long-term trends in water quality.To analyze s Dong-gang River long-term water quality trends and pollution characteristics. The results showed that the bridge measuring ammonia Long-dong, BOD5 measure in that station on a downward trend, DO, and SS is on the rise, River Pollution Index (RPI) on a downward trend. The results form Chau-Jhou station also ahowed simialar trends .more and more near the

  17. Hrob nemlčí pevněji nežli Vy : (Dopisy Jiřího Karáska, Arnošta Procházky, Jiřiny Böhmové a Antonína Trýba)

    Czech Academy of Sciences Publication Activity Database

    Färber, Vratislav (ed.)

    2007-01-01

    Roč. 18, č. 4 (2007), s. 163-170 ISSN 0862-6928 R&D Projects: GA ČR GA405/05/2152 Institutional research plan: CEZ:AV0Z90560517 Keywords : Kamil Fiala * Jiří Karásek ze Lvovic * Arnošt Procházka * Jiřina Böhmová * Antnoní Trýb Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. CDM and JI in View of the Sustainability Debate

    OpenAIRE

    Schoot Uiterkamp, A.J.M.

    2001-01-01

    Clean Development Mechanism (CDM), Joint Implementation (JI) and emissions trading are the three flexible instruments incorporated in the Kyoto Protocol. This paper presents a critical assessment of the sustainability of energy-related technology innovation and transfer in the context of CDM and JI. The rebound effect is discussed by comparing intended and unintended project and process outcomes. Attention is given to the role of nations and key actors like multinationals in achieving sustain...

  19. Jiří Wolker, osobnost a dílo

    OpenAIRE

    Rufertová, Kamila

    2010-01-01

    Jiří Wolker, a poet born at the beginning of the 20th century, enjoyed great popularity among literary critics as well as readers. The reception of his work was marked with controversial interpretations, which resulted in the critical movement Dosti Wolkera (Enough Wolker) in 1925. Wolker's work has been described as "Proletarian", but his lyrical writings achieved high quality and there is much more in it. Jiří Wolker had been appreciated as a very talented and hard-working personality. He b...

  20. Tai Ji Quan: An overview of its history, health benefits, and cultural value

    Directory of Open Access Journals (Sweden)

    Yucheng Guo

    2014-03-01

    Full Text Available Tai Ji Quan is considered to be a part of traditional Chinese Wushu (a martial art and comprises various styles that have evolved historically from the Chen, Yang, Wǔ, Wú, and Sun families (schools. Recent simplification of the original classic styles has made Tai Ji Quan easier to adopt in practice. Thus, the traditional legacy of using Tai Ji Quan for self-defense, mindful nurturing of well-being, and fitness enhancement has been expanded to more contemporary applications that focus on promoting physical and mental health, enhancing general well-being, preventing chronic diseases, and being an effective clinical intervention for diverse medical conditions. As the impact of Tai Ji Quan on physical performance and health continues to grow, there is a need to better understand its historical impact and current status. This paper provides an overview of the evolution of Tai Ji Quan in China, its functional utility, and the scientific evidence of its health benefits, as well as how it has been a vehicle for enhancing cultural understanding and exchanging between East and West.

  1. Source identification and mass balance studies of mercury in Lake An-dong, S. Korea

    Science.gov (United States)

    Han, J.; Byeon, M.; Yoon, J.; Park, J.; Lee, M.; Huh, I.; Na, E.; Chung, D.; Shin, S.; Kim, Y.

    2009-12-01

    In this study, mercury and methylmercury were measured in atmospheric, tributary, open-lake water column, sediment, planktons and fish samples in the catchments area of Lake An-dong, S. Korea. Lake An-dong, an artificial freshwater lake is located on the upstream of River Nak-dong. It has 51.5 km2 of open surface water and 1.33 year of hydraulic residence time. It is a source of drinking water for 0.3 million S. Koreans. Recently, the possibilities of its mercury contamination became an issue since current studies showed that the lake had much higher mercury level in sediment and certain freshwater fish species than any other lakes in S. Korea. This catchments area has the possibilities of historical mercury pollution by the location of more than 50 abandoned gold mines and Young-poong zinc smelter. The objective of this study was to develop a mercury mass balance and identify possible mercury sources in the lake. The results of this study are thus expected to offer valuable insights for the sources of mercury loading through the watershed. In order to estimate the mercury flux, TGM, RGM and particulate mercury were measured using TEKRAN 2537 at the five sites surrounding Lake An-dong from May, 2009 with wet and dry deposition. The fate and transport of mercury in water body were predicted by using EFDC (Environmental Dynamic Fluid Code) and Mercury module in WASP7 (Water quality analysis program) after subsequent distribution into water body, sediments, followed by bioaccumulation and ultimate uptake by humans. The mercury mass balance in Young-poong zinc smelter was also pre-estimated by measuring mercury content in zinc ores, emission gases, sludge, wastewater and products.

  2. Jičín - město pohádky a cestovní ruch

    OpenAIRE

    Šarbortová, Kateřina

    2011-01-01

    The bachelor's thesis deals with Jičín and festival Jičín - the town of fairytale. First chapter characterizes the importance of tourism, types of tourism, its destination and marketing in tourism. The following part deals with Královéhradecký region, the town of Jičín and its tourist attractions. The next chapter describes festival Jičín - the town of fairytale. The last chapter analyses the influence of the festival on tourism of the town and its surroundings.

  3. Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats.

    Science.gov (United States)

    Gurav, S D; Gilibili, R R; Jeniffer, S; Mohd, Z; Giri, S; Govindarajan, R; Srinivas, N R; Mullangi, R

    2012-01-01

    JI-101, chemically 1-[1-(2-amino-pyridin-4-ylmethyl)-1H-indol-4-yl]-3-(5-bromo-2-methoxy-phenyl)-urea hydrochloride, is a novel orally active kinase inhibitor, which has shown potent in vitro and in vivo anticancer activity against a variety of cancer cell lines and xenografts. It is currently entering Phase II clinical development for the treatment of solid tumors. The aim of the study is to assess the metabolic stability of JI-101 in various pre-clinical and human liver microsomes, to identify the major CYPs (cytochrome β450) involved in the metabolism of JI-101 and identification of putative metabolites. We have also studied the pharmacokinetics, tissue distribution and excretion of JI-101 in Sprague Dawley rats. JI-101 was found to be stable in various liver microsomes tested. JI-101 is highly permeable and not a substrate for P-gp (permeability glycoprotein). JI-101 excreted through bile along with its mono- and di-hydroxy metabolites. Following oral administration, JI-101 was rapidly absorbed, reaching Cmax within 2 h. The t½ of JI-101 with intravenous and oral route was found to be 1.75 ± 0.79 and 2.66 ± 0.13 h, respectively. The Cl and Vd by intravenous route for JI-101 were found to be 13.0 ± 2.62 mL/min/kg and 2.11 ± 1.42 L/kg, respectively. The tissue distribution of JI-101 was extensive with rapid and preferred uptake into lung tissue. Overall, the oral bioavailability of JI-101 is 55% and the primary route of elimination for JI-101 is feces. © Georg Thieme Verlag KG Stuttgart · New York.

  4. Genomewide identification, classification and analysis of NAC type ...

    Indian Academy of Sciences (India)

    Supplementary data: Genomewide identification, classification and analysis of NAC type gene family in maize. Xiaojian Peng, Yang Zhao, Xiaoming Li, Min Wu, Wenbo Chai, Lei Sheng, Yu Wang, Qing Dong,. Haiyang Jiang and Beijiu Cheng. J. Genet. 94, 377–390. Table 1. Detailed information of NAC proteins in maize.

  5. Acupuncture (針灸 Zhēn Jiǔ – An Emerging Adjunct in Routine Oral Care

    Directory of Open Access Journals (Sweden)

    Devanand Gupta

    2014-10-01

    Full Text Available Acupuncture (針灸 Zhēn Jiǔ (‘acus’ (needle+‘punctura’ (to puncture is the stimulation of specific points along the skin of the body involving various methods such as penetration by thin needles or the application of heat, pressure, or laser light. Acupuncture (針灸 Zhēn Jiǔ aims to treat a range of medical and dental ailments, though is most commonly used for pain relief. This article reviews about the various possible roles of acupuncture (針灸 Zhēn Jiǔ in clinical dental practice. Acupuncture (針灸 Zhēn Jiǔ has potential in supplementing conventional treatment procedures by its diverse applicability outreach. Role of acupuncture (針灸 Zhēn Jiǔ in dental practice has been well supported by clinical trials. Its role in alleviating facial pain, pre-operative and post-operative dental pain has led to its widespread application. Its role as sole analgesic for treatment procedure has to be tested. It's It is a thought that acupuncture (針灸 Zhēn Jiǔ may prove an indispensible supplement to conventional treatment modalities and more of clinical trials and studies are required to prove the efficacy. Acupuncture (針灸 Zhēn Jiǔ is not a miracle cure and is not going to replace the drill. However, the technique can be a supplement to conventional treatments in TMDs, facial pain, pain management Sjoegrens syndrome, and in phobias and anxiety. The application and use of Acupuncture (針灸 Zhēn Jiǔ comes with some side effects. Proper training needs to be obtained before commencement of any procedure related to acupuncture (針灸 Zhēn Jiǔ. Various training programs are offered to train clinical practitioners the apt method to use acupuncture (針灸 Zhēn Jiǔ.

  6. Poster - Thurs Eve-16: Just-in-time tomography (JiTT).

    Science.gov (United States)

    Pang, G; Rowlands, J A

    2008-07-01

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room for image-guided radiation therapy. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus is not adequate for imaging targets with intrafraction motion. In this work, a new concept for image-guided radiation therapy- just-in-time tomography (JiTT) - is introduced. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. A system to achieve JiTT is proposed and its feasibility is investigated. Research supported by Siemens. © 2008 American Association of Physicists in Medicine.

  7. On the Melody Types between the North and the South Dong Folks%南北侗族民歌的旋律类型探究

    Institute of Scientific and Technical Information of China (English)

    苏金梅

    2014-01-01

    South and North Dong Minority , the two branches of Dong , have remarkable differences in the music style of folk songs . South Dong'folk song is mild and obscure while North Dong'folk song is lyric and straightforward . The formation of their differences is closely related to their melody types :the melody type of South Dong's folk song is mainly small wave while the melody type of North Dong's folk song is with ups and small wave ;though both South and North Dong's folk songs enjoy small wave type , there are differences in the music development mode of small wave type . The differences of melody types in South and North Dong's folk songs are connected with their own cultural ecology , i . e , the differences of South and North Dong area's ecological and cultural environment mold out the characteristics of South and North Dong's folk song which is reflected in their different melody types .%南、北侗族作为侗族旗下的两个分支,在民歌音乐风格方面差别显著:南侗民歌平和、含蓄,北侗民歌抒情、直白。这种差异的形成与二者的旋律类型存有紧密联系:南侗民歌的旋律类型仅以小波浪式为主,北侗民歌以跌宕式与小波浪式两种类型为主;南北侗族民歌虽都喜好小波浪式,但二者的小波浪式在音乐发展模式上也不同。而南、北侗族民歌旋律类型的差异正好与彼此所处的文化生态是相互耦合的,也即是说,南、北侗族地区生态文化环境的差异模塑出南北侗族民歌的特性,这一特性在其民歌的旋律类型中得以表现。

  8. A Robust and Resilient Network Design Paradigm for Region-Based Faults Inflicted by WMD Attack

    Science.gov (United States)

    2016-04-01

    Infrastructure Mapping over Transport Software - Defined Networks (T- SDN )”, IEEE/OSA OFC, 2014 (invited for a special issue of OSA/IEEE JOCN) 23. L. Liu, J...Ji and C. Qiao “Survivable Virtual Infrastructure Mapping with Shared Protection in Transport Software - Defined Networks (T- SDNs )”, OECC, 2014. 25. S...483-493, 2014. 21. Z. Ye, X. Li, A. N. Patel, P. N. Ji, X. Cao, C. Qiao, “Upgrade-aware Virtual Infrastructure Mapping in Software - Defined Elastic

  9. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine

    Directory of Open Access Journals (Sweden)

    Taehyung Lee

    2014-01-01

    Full Text Available Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam’s acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods.

  10. Analysis of poultry eating and drinking behavior by software eYeNamic

    Directory of Open Access Journals (Sweden)

    A. De Montis

    2013-09-01

    Full Text Available Constant presence of at least one operator in livestock buildings for broilers would allow a perfect control of animal behaviour and, especially, deviations in feeding and drinking patterns, in the perspective of a high welfare status. However, as nowadays it is impossible for a farmer to be present in the farm all day long, automatic monitoring systems are required. The purpose of this paper is to introduce a system (eYeNamic for automatic monitoring and analyzing broilers’ behavior in a farm. eYeNamic is a camera system introduced and produced by Fancom BV, a company operating in the field of automation of livestock facilities. It includes three cameras located on the ridge of the broiler house and able to monitor chickens’ behaviour twenty-four hours a day. Through eYeNamic it is possible to process the images and to obtain a measure of animals’ distribution and activity, which can be conceived as valuable indicators of animal welfare. The study presented in this paper was divided into several phases: data collection, images visualization, observation of the distribution and activity of the chickens, and statistical analysis of the observations. The analysis of correlation between the number of 14 days old broilers near the feeding line (manual counted and the average occupation density measured with eYenamic indicates that the best conditions have occurred with a 50 cm by 75 cm area around each feeding pan. With reference to the drinking line, the best response was found in an area 50 cm wide and the whole drinking line long. For the activity behavior, there was no significant correlation between activity and number of chickens eating from all the pans: this confirms that broilers while eating reduce their activity. It was concluded from this study that eYeNamic is a good system to observe animal behavior and, especially, to take care of their drinking and eating behaviour. A satisfactory correspondence between eYeNamic remote and

  11. Lowering the YE+1 end-cap for CMS

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    On 9 January 2007, the massive YE+1 end-cap was lowered into the CMS cavern. This is a very precise process as the crane must lower the end-cap through minimal clearance without tilt or sway. Once in the cavern, the end-cap is then positioned over the end of the barrel to detect particles produced in collisions that travel close to the axis of the beams.

  12. High frequency plant regeneration from mature seed- derived callus ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-15

    Dec 15, 2009 ... Ki-Won Lee, Gi Jun Choi, Ki-Yong Kim, Hee Chung Ji, Hyung Soo Park, Sei Hyung Yoon and ... Gramineae family plants (Ha et al., 2001; Dong and Qu, ..... Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, ...

  13. Long-term prospects of CDM and JI; Langfristige Perspektiven von CDM und JI

    Energy Technology Data Exchange (ETDEWEB)

    Cames, Martin; Anger, Niels; Boehringer, Christoph; Harthan, Ralph O.; Schneider, Lambert [Oeko-Institut, Berlin (Germany)

    2007-07-15

    This study analyses whether Germany should use the flexible mechanisms under the Kyoto protocol or whether it should continue to achieve its greenhouse gas reduction targets by dint of domestic policies and measures. It estimates the future potential of the project-based Kyoto mechanisms (CDM and JI) and the impacts of its use on the German and the global economy, using an integrated-assessment model. In a Delphi survey, the expectations of international experts on the future prospects of the project-based Kyoto mechanisms are assessed. The study finishes with an analysis of options for promoting the use of the flexible mechanisms in Germany and concludes that the Federal Government of Germany should establish a project-based mechanisms fund of 25 to 50 million Kyoto units to cover the compliance uncertainties due to unexpected temperature or business cycle variations. (orig.) [German] Diese Studie untersucht, ob Deutschland die flexiblen Mechanismen unter dem Kyoto-Protokoll nutzen sollte oder weiterhin seine Treibhausgasreduktionsziele durch inlaendische Politiken und Massnahmen erreichen sollte. Das kuenftige Potenzial der projektbezogenen Kyoto-Mechanismen (CDM und JI) wird untersucht und die Auswirkungen von deren Nutzung auf die deutsche und globale Wirtschaft werden mit einem Integrated-Assessment-Modell abgeschaetzt. In einer Delphi-Befragung werden die Erwartungen internationaler Experten in Hinblick auf die kuenftigen Perspektiven der projektbezogenen Kyoto- Mechanismen ermittelt. Abschliessend werden Moeglichkeiten zur Foerderung der Nutzung der flexiblen Mechanismen in Deutschland analysiert, mit der Schlussfolgerung, dass die Bundesregierung einen 25 bis 50 Millionen Kyoto-Einheiten umfassenden Fonds fuer projektbezogene Mechanismen einrichten sollte, um die Unsicherheiten bei der Erfuellung des Kyoto-Ziels infolge unerwarteter Temperaturschwankungen oder einer Aenderung der Konjunkturentwicklung abzudecken. (orig.)

  14. Implementing the Kyoto protocol : why JI and CDM show more promise than international emissions trading

    NARCIS (Netherlands)

    Woerdman, E.

    The Kyoto protocol allows developed countries to achieve cost-effective greenhouse gas emission reductions abroad by means of international emissions trading (IET), joint implementation (JI) and the clean development mechanism (CDM). The article argues that JI and CDM projects will be more

  15. Lowering of the YE+2 end-cap for CMS

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Lowering of the second end-cap disk of CMS, designated YE+2, took place on 12 December 2006. The huge disk, 15 m high and weighing around 900 tonnes, is equipped on both sides with muon detectors. The lowering operation started at around 7am and finished about 10 hours later with the arrival of the disk into the cavern 100 m below the surface hall.

  16. [A randomized, double-blind, controlled study: Ji-Tai tablet for the treatment of acute withdrawl syndrome of mild heroin dependence].

    Science.gov (United States)

    Wang, Yuhong; Tang, Cuiqing; Cheng, Shuang; Cui, Guimei; Zhang, Ruiling; Zhang, Zhiyong; Xie, Lingyin; Lin, Yongxiong; Hao, Wei

    2015-02-01

    To investigate the efficacy and safety of Ji-Tai tablet and Ji-Tai tablet combined with buprenorphine in the treatment of patients with acute withdrawal syndrome of mild heroin dependence. A total of 150 patients with mild heroin dependence were recruited, and were randomly assigned to a Ji-Tai tablet group (n=50), a Ji-Tai tablet combined with buprenorphine group (n=50) and a control group (n=50) during a 10-day clinical trial. Opiate withdrawal scale (OWS) was used to measure the severity of withdrawal symptoms. Anxiety symptoms assessments were made at 0 day (baseline), the day 5 (middle), and the day 10 (end) by the Hamilton anxiety scale (HAMA). Symptoms were assessed before and 1 h or 2 h after medication each day. The total withdrawal symptoms scores and the daily reduction rate were used to measure the effect of Ji-Tai tablet vs Ji- Tai tablet plus buprenorphine. Safety evaluation was carried out by the following measures: baseline of treatment, drug side effects after the treatment, vital signs (blood pressure, heart rate, and respiration rate), laboratory examination (routine blood and urine tests and the liver and kidney function tests), and electrocardiograms. A total of 142 mild heroin dependence patients performed the experiments (including 48 in the Ji-Tai tablet group, 48 in the Ji-Tai tablet with buprenorphine group and 46 in the control group). The scores of baseline withdrawal symptoms were 43.520±19.786, 42.640±17.648 and 47.100±24.450, respectively, with no significant differences among the 3 groups (all P>0.05 ). During the 10-day treatment, the reduction rate of acute withdrawal symptoms scores increased daily, the acute withdrawal syndrome scores and the anxiety symptoms scores declined from day 0 to day 10, there was also no significant difference among the 3 groups (all P>0.05). Ji-Tai tablet did not affect vital signs such as blood pressure, heart rate, and respiration rate. Ji-Tai tablet or Ji-Tai tablet combined with buprenorphine

  17. Pt-Pd nanoelectrocatalyst of ultralow Pt content for the oxidation of ...

    Indian Academy of Sciences (India)

    formic acid oxidation on Pt4Pd96 nanoparticles. Keywords. ..... Choi J H, Jeong K J, Dong Y, Han J, Lim T H, Lee J S ... Rhee C K, Kim B J, Ham C, Kim Y J, Song K and Kwon ... Wang R, Liao S and Ji S 2008 J. Power Sources 180 205. 18.

  18. Suspected primary immune deficiency in a Donge de Bordeaux dog : short communication

    Directory of Open Access Journals (Sweden)

    R.G. Lobetti

    2002-07-01

    Full Text Available A young Donge de Bordeaux dog was presented with chronic intermittent antibiotic responsive gastrointestinal and respiratory disease. Further evaluation showed bacterial lymphadenitis, bacterial tracheitis, normal white cell and differential cell counts, hypogammaglobulinaemia, and the absence of B-lymphocytes but the presence of T-lymphocytes in the lymphoid tissue stained with lymphocyte markers. As the dog came from a narrow genetic base, with related dogs showing similar clinical signs, possible B-cell congenital immune deficiency was suspected.

  19. Jiří Musil a sociální teorie

    Czech Academy of Sciences Publication Activity Database

    Skovajsa, Marek

    2012-01-01

    Roč. 48, č. 5 (2012), s. 1003-1008 ISSN 0038-0288 Institutional support: RVO:68378025 Keywords : Czech sociology * social theory * Jiří Musil (1928-2012) Subject RIV: AO - Sociology, Demography Impact factor: 0.652, year: 2012

  20. Oligosaccharide nanomedicine of alginate sodium improves therapeutic results of posterior lumbar interbody fusion with cages for degenerative lumbar disease in osteoporosis patients by downregulating serum miR-155

    OpenAIRE

    Qu Y; Wang Z; Zhou H; Kang M; Dong R; Zhao J

    2017-01-01

    Yang Qu, Zhengming Wang, Haohan Zhou, Mingyang Kang, Rongpeng Dong, Jianwu Zhao Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People’s Republic of China Abstract: Degenerative lumbar disease (DLD) is a significant issue for public health. Posterior lumbar intervertebral fusion with cages (PLIFC) has high-level fusion rate and realignment on DLD. However, there are some complications following the surgery. Alginate oligosaccharides (AOS) have antiox...

  1. Biologically Assembled Quantum Electronic Arrays

    Science.gov (United States)

    2013-06-07

    Koh , Faxian Xiu, Xingchen Ye, Dong-Kyun Ko, Kang L. Wang, Cherie R. Kagan, Christopher B. Murray. Multiscale Periodic Assembly of Striped Nanocrystal...study is the LlM method (See M. T. Raman et al, Applied . Physics L etters 94, 042507, 2009). This method is a type of first-order reversal...Demonstrated graphene field- effect transistor: (top) optical Image of transferred graphene, (middle) Raman spectrum, (bottom) current voltage

  2. ZHANG Ting-dong (张亭栋)—— A Pioneer in Treating Leukemia with Arsenous Acid

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Prof. ZHANG Ting-dong, male, was born in Wuqiao County, He-bei Province on Nov. 8,1932, and in 1950 graduated from Harbin Medical University. And from 1960 to 1963 he studied in and then graduated from Western Doctors'class for Learning Traditional Chinese Medicine(TCM).

  3. Water footprint of Jing-Jin-Ji urban agglomeration in China

    Science.gov (United States)

    Zhao, D.

    2017-12-01

    A rapidly expanding economy and increasing water demand for economic production is placing enormous stress on water quantity and aquatic environment in Northern China, especially the so-called Jing-Jin-Ji (Beijing-Tianjin-Hebei) urban agglomeration. Several studies have focused on energy consumption, air pollution, CO2 emissions and regional blue water footprint (WF) following release of the Jing-Jin-Ji Integration Strategy by the China government. However, a comprehensive assessment distinguishing blue, green and grey WF amongst different industrial sectors, ascertaining how WF transfers internally and beyond the region and final demand consumption is not available. In this study, we quantified the WF and virtual water flow on a sectoral basis for the year 2010 through coupling the multi-regional input-output model (MRIO) with WF assessment. The results showed that Beijing and Tianjin are net importers of green, blue and grey water from Hebei and other provinces to support their needs. Conversely, Hebei exports all WF colors to Beijing, Tianjin and other provinces in China, more than 60% of WF is transferred as virtual water. For the overall Jing-Jin-Ji region a small amount of blue water (2,086 million m3) is exported, but huge amounts of green water (15,573 million m3) and grey water (30,620 million m3) are outsourced. A "Virtual Water Strategy" is one measure which could alleviate water stress at the regional scale, with consideration of financial compensation from water receiving regions made to water supplying regions for achieving water management targets. We also found that physical water transfer to Jing-Jin-Ji could not balance virtual blue water exports. Our research suggests that a continuation of an export-based economic development model will worsen Hebei's water stress. Reducing the dependency of Hebei's sectoral economy on export of water intensive and low value added agricultural products may be one strategy to reduce the pressure on regional water

  4. Jagten på afkast, DONG, illikviditet og performanceevaluering

    DEFF Research Database (Denmark)

    Bechmann, Ken L.

    2014-01-01

    I denne leder diskuteres alternative investeringer i lyset af de forskellige artikler, der haves i dette nummer af Finans/Invest. Med udgangspunkt i artiklen om jagten på afkast samt en rapport fra Finanstilsynet om alternative investeringer starter lederen med at beskrive omfanget og den stigende...... fokus, der er på alternative investeringer, og diskuterer endvidere de udfordringer som investorerne har i forhold til specielt risikoen. Lederen nævner her politisk risiko som ét eksempel på en kompliceret risiko og fremhæver her blandt andet hele forløbet omkring DONG som et aktuelt eksempel....... Illikviditet er en anden central risiko, som investorerne må forholde sig til i forbindelse med alternative investeringer. Artiklen om illikviditet i dette nummer viser, at det også er behæftet med udfordringer at behandle illikviditet i forbindelse med værdiansættelse....

  5. A journey through discrete mathematics a tribute to Jiří Matoušek

    CERN Document Server

    Nešetřil, Jaroslav; Thomas, Robin

    2017-01-01

    This collection of high-quality articles in the field of combinatorics, geometry, algebraic topology and theoretical computer science is a tribute to Jiří Matoušek, who passed away prematurely in March 2015. It is a collaborative effort by his colleagues and friends, who have paid particular attention to clarity of exposition – something Jirka would have approved of. The original research articles, surveys and expository articles, written by leading experts in their respective fields, map Jiří Matoušek’s numerous areas of mathematical interest.

  6. A new dimeric anthraquinone from endophytic Talaromyces sp. YE3016.

    Science.gov (United States)

    Xie, Xiao-Song; Fang, Xiao-Wei; Huang, Rong; Zhang, Shou-Peng; Wei, Hong-Xia; Wu, Shao-Hua

    2016-08-01

    A new unsymmetrical dimeric anthraquinone, 3-demethyl-3-(2-hydroxypropyl)-skyrin (1) was isolated from the solid-state fermentation extract of an endophytic fungal strain Talaromyces sp. YE 3016, together with five known compounds, skyrin (2), oxyskyrin (3), emodin (4), 1,3,6-trihydroxy-8-methyl-anthraquinone (5) and ergosterol (6). The structure of the new compound was elucidated on the basis of spectroscopic analysis. Compounds 1-3 exhibited moderate cytotoxic activities against MCF-7 cell line.

  7. [Textual research on circulation of the Ming edition of Li Heng's Xiu zhen fang (Pocket Formulary)].

    Science.gov (United States)

    Yang, Jinping; Liu, Peng; Lu, Mingjing; Lu, Xing; Li, Shaolin; Jin, Xiumei

    2015-03-01

    Xiu zhen fang (Pocket Formulary) is a recipe book of the Ming Dynasty, inspired and managed by Zhu Su, compiled by Li Heng of liangyisuo (good physician house) in Zhou wangfu (Zhou's royal palace). The book was compiled and published twice during the reigns of the Hongwu and Yongle Emperors of the Ming Dynasty. Because of its high practicability, there were some editions in circulation, and the book was published several times only in the Ming Dynasty. At present, the earliest extanteditionwas the little character version of Yongle, and the version in the 4(th) year of Zhengde Emperor of the Ming Dynasty was a reprinting edition based on the Yongle edition, sharingthe same edition system. Most of the editions appeared after the reign of Zhengtong Emperor of the Ming Dynasty, titled by "kui ben (head version)" and "da quan (complete edition)" were the editionspublished in the local bookshops, which had rather distinct differences from the Yongle edition system not only in the its format but also in its contents.

  8. Enhancing the bioactivity of Poly(lactic-co-glycolic acid scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model

    Directory of Open Access Journals (Sweden)

    Wang DX

    2013-05-01

    Full Text Available De-Xin Wang,1,* Yao He,2,* Long Bi1,* Ze-Hua Qu,2 Ji-Wei Zou,1 Zhen Pan,2 Jun-Jun Fan,1 Liang Chen,2 Xin Dong,1 Xiang-Nan Liu,2 Guo-Xian Pei,1 Jian-Dong Ding,21Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China; 2State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, People's Republic of China*These authors contributed equally to this workPurpose: Poly(lactic-co-glycolic acid (PLGA is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keeping the polyester skeleton of the scaffolds.Methods: PLGA porous scaffolds were prepared and surface modification was carried out by incubation in modified simulated body fluids. The nHA coated PLGA scaffolds were compared to the virgin PLGA scaffolds both in vitro and in vivo. Viability and proliferation rate of bone marrow stromal cells of rabbits were examined. The constructs of scaffolds and autogenous bone marrow stromal cells were implanted into the segmental bone defect in the rabbit model, and the bone regeneration effects were observed.Results: In contrast to the relative smooth pore surface of the virgin PLGA scaffold, a biomimetic hierarchical nanostructure was found on the surface of the interior pores of the nHA coated PLGA scaffolds by scanning electron microscopy. Both the viability and proliferation rate of the cells seeded in nHA coated PLGA scaffolds were higher than those in PLGA scaffolds. For bone defect repairing, the radius defects had, after 12 weeks implantation of nHA coated PLGA scaffolds, completely recuperated with significantly better bone formation than in

  9. THE TYPES OF PLANS AND INTERIOR DESIGN AT MEMORIAL CLOISTERS OF DAITOKU-JI AND MYOSHIN-JI TEMPLES IN KYOTO IN THE EDO PERIOD [1596~1868] -The Development and Changes of the Sanctuary-

    Directory of Open Access Journals (Sweden)

    Antariksa Antariksa

    2003-01-01

    Full Text Available In the early Edo period the number of memorial cloisters (tacchu increased, especially, at Daitoku-ji and Myôshin-ji temples. As a consequence, the hondô (kyakuden, hojo were further developed in all aspects of architectural style, interior design and plan. This study will attempt to clarify the types of plans at memorial cloisters of both temples, by analyzing the arrangement and composition of the sanctuary, during the Edo period. In that period, the requirement of the rooms was interlaced with the function, and even dependent upon everyday life and the activities of religious services.

  10. Neuronal nitric oxide synthase inhibition prevents cerebral palsy following hypoxia-ischemia in fetal rabbits: comparison between JI-8 and 7-nitroindazole.

    Science.gov (United States)

    Yu, Lei; Derrick, Matthew; Ji, Haitao; Silverman, Richard B; Whitsett, Jennifer; Vásquez-Vivar, Jeannette; Tan, Sidhartha

    2011-01-01

    Cerebral palsy and death are serious consequences of perinatal hypoxia-ischemia (HI). Important concepts can now be tested using an animal model of cerebral palsy. We have previously shown that reactive oxygen and nitrogen species are produced in antenatal HI. A novel class of neuronal nitric oxide synthase (nNOS) inhibitors have been designed, and they ameliorate postnatal motor deficits when administered prior to the hypoxic-ischemic insult. This study asks how the new class of inhibitors, using JI-8 (K(i) for nNOS: 0.014 μM) as a representative, compare with the frequently used nNOS inhibitor 7-nitroindazole (7-NI; K(i): 0.09 ± 0.024 μM). A theoretical dose equivalent to 75 K(i) of JI-8 or equimolar 7-NI was administered to pregnant rabbit dams 30 min prior to and immediately after 40 min of uterine ischemia at 22 days gestation (70% term). JI-8 treatment resulted in a significant decrease in NOS activity (39%) in fetal brain homogenates acutely after HI, without affecting maternal blood pressure and heart rate. JI-8 treatment resulted in 33 normal kits, 2 moderately and 13 severely affected kits and 5 stillbirths, compared with 8 normal, 3 moderately affected and 5 severely affected kits and 10 stillbirths in the 7-NI group. In terms of neurobehavioral outcome, 7-NI was not different from saline treatment, while JI-8 was superior to saline and 7-NI in its protective effect (p JI-8 significantly improved the locomotion score over both saline and 7-NI scores. JI-8 was also significantly superior to saline in preserving smell, muscle tone and righting reflex function, but 7-NI did not show significant improvement. Furthermore, a 100-fold increase in the dose (15.75 μmol/kg) of 7-NI significantly decreased systolic blood pressure in the dam, while JI-8 did not. The new class of inhibitors such as JI-8 shows promise in the prevention of cerebral palsy and is superior to the previously more commonly used nNOS inhibitor. Copyright © 2011 S. Karger AG, Basel.

  11. Presence of e-EDCs in surface water and effluents of pollution sources in Sai Gon and Dong Nai river basin

    Directory of Open Access Journals (Sweden)

    Tam Le Thi Minh

    2016-01-01

    Full Text Available This study aimed to assess the presence of estrogenic endocrine disrupting compounds (e-EDCs including estriol, bisphenol A (BPA, atrazine (ATZ, octylphenol, octylphenol diethoxylate, octylphenol triethoxylate, nonylphenol, Nonylphenol triethoxylate (NPE3, nonylphenol diethoxylate (NPE2 and 17β-estradiol in: (i Sai Gon and Dong Nai river waters which have been major raw water sources for drinking water supply for Ho Chi Minh City (HCMC and neighbouring provinces, and (ii water pollution sources located in their catchment basin. NPE3 and NPE2 were detected in most of the surface water samples. Concentrations of NPE3 were in a range of less than 5.9–235 ng L−1, whereas BPA was detected at significantly high concentrations in the dry season in canals in HCMC. In the upstream of Sai Gon and Dong Nai Rivers, ATZ concentrations were observed at water intake of water treatment plants served for HCMC water supply system. Similarly, high potential risk of NPE2 and NPE3 contamination at Phu Cuong Bridge near Hoa Phu water intake was identified. The significant correlation between NPE2, dissolved organic carbon and total nitrogen was found. Estrogenic equivalent or estrogenic activity of Sai Gon and Dong Nai Rivers was lower than those of the previous studies. Compared with other studies, e-EDCs of pollution in Sai Gon river basin were relatively low.

  12. Marketingový plán fitness centra Expreska Jiřího z Poděbrad

    OpenAIRE

    Štěchová, Kristýna

    2016-01-01

    Title: The marketing plan of fitness center Expreska Jiřího z Poděbrad. Objectives: The main aim of the dimploma thesis is to construct a marketing plan for fitness center Expreska Jiřího z Poděbrad for the year 2017. The proposed marketing strategy, including the implementation plan will be directed to achieve marketing and business goals of the organization. Methods: For analysis of the microenvironment is used Porter matrix. Analysis of macroenvironment is done with the help of PEST analys...

  13. Economic Evaluation of a Tai Ji Quan Intervention to Reduce Falls in People With Parkinson Disease, Oregon, 2008-2011.

    Science.gov (United States)

    Li, Fuzhong; Harmer, Peter

    2015-07-30

    Exercise is effective in reducing falls in people with Parkinson disease. However, information on the cost effectiveness of this approach is lacking. We conducted a cost-effectiveness analysis of Tai Ji Quan for reducing falls among patients with mild-to-moderate Parkinson disease. We used data from a previous intervention trial to analyze resource use costs related to intervention delivery and number of falls observed during a 9-month study period. Cost effectiveness was estimated via incremental cost-effectiveness ratio (ICER) in which Tai Ji Quan was compared with 2 alternative interventions (Resistance training and Stretching) on the primary outcome of per fall prevented and the secondary outcome of per participant quality-adjusted life years (QALY) gained. We also conducted subgroup and sensitivity analyses. Tai Ji Quan was more effective than either Resistance training or Stretching; it had the lowest cost and was the most effective in improving primary and secondary outcomes. Compared with Stretching, Tai Ji Quan cost an average of $175 less for each additional fall prevented and produced a substantial improvement in QALY gained at a lower cost. Results from subgroup and sensitivity analyses showed no variation in cost-effectiveness estimates. However, sensitivity analyses demonstrated a much lower ICER ($27) when only intervention costs were considered. Tai Ji Quan represents a cost-effective strategy for optimizing spending to prevent falls and maximize health gains in people with Parkinson disease. While these results are promising, they warrant further validation.

  14. Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

    OpenAIRE

    Chen,Wei; Ju,Jing; Yang,Yehong; Wang,Hao; Chen,Wenjie; Zhao,Xuelan; Ye,Hongying; Zhang,Yu

    2018-01-01

    Wei Chen,1 Jing Ju,1 Yehong Yang,2 Hao Wang,3 Wenjie Chen,1 Xuelan Zhao,1 Hongying Ye,2 Yu Zhang1 1Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, China; 2Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, China; 3Core Center of Animal Facility, School of Medicine, Fudan University, Shanghai, China Introduction: Diabetic cardiomyopathy is characterized by an imbalance between myocyte death and regeneration mediated by the progressive loss of c...

  15. Atomically Phase-Matched Second-Harmonic Generation in a 2D Crystal

    Science.gov (United States)

    2016-08-26

    OPEN ORIGINAL ARTICLE Atomically phase-matched second-harmonic generation in a 2D crystal Mervin Zhao1,2,*, Ziliang Ye1,2,*, Ryuji Suzuki3,4,*, Yu...photoluminescence mapping, Raman spectroscopy and atomic -force microscopy. (b) Image produced via scanning and gathering the SH light produced by the 3R-MoS2...arising from a single atomic layer, where the SH light elucidated important information such as the grain boundaries and electronic structure in these ultra

  16. Porous and Phase Change Nanomaterials For Photonic Applications

    Science.gov (United States)

    2014-08-28

    Y. Han , M. S. Zhao, G. Morthier, and R. Baets. Athermal silicon-on-insulator ring resonators by overlaying a polymer cladding on narrowed waveguides...integrated photonics. Advanced Materials, 22(23):2561, 2010. [152] T. Sondergaard, S. M. Novikov, T. Holmgaard, R. L. Eriksen, J. Beermann, Z. H. Han , K...726, 2011. [181] N. N. Feng, D. Z. Feng, S. R. Liao, X. Wang, P. Dong, H. Liang, C. C. Kung , W. Qian, J. Fong, R. Shafiiha, Y. Luo, J. Cunningham, A. V

  17. CMS RPC detectors assembled in Pakistan installed on the backside of the YE+1 endcap yoke

    CERN Multimedia

    Walter Van Doninck, VUB-Brussels and CERN

    2006-01-01

    Resistive Plate Chambers (RPCs) are sensitive to the passage of muons and provide a "trigger" signal for CMS. This image shows RPC detectors, which were assembled in Pakistan, installed on the backside of an endcap yoke disc, known as YE+1.

  18. Etiology and radiologic findings of anoxia occurred at Dan-Mu-Ji(Salted radish in rice bran) manufacture: A case report and results of gas analysis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Choong Ki; Kim, Heung Cheol; Ahn, Bum Gyu; Park, Man Soo; Hwang, Woo Cheol; Choi, Cheol Soon; Kang, Ik Won [College of Medicine, Hallym University, Chunchon (Korea, Republic of); Kim, Man Goo [Kangwon National University, Chunchon (Korea, Republic of)

    1994-07-15

    To identify the main toxic gas released from salted radish in rice bran(Dan-Mu-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analyzed by using the gas chromatography. The radiographic examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consideration in both lung. The headspace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.

  19. Climate Change Policy Measures in Japan: NEDO's Activities to Promote CDM/JI

    International Nuclear Information System (INIS)

    Fukasawa, Kazunori; Seki, Kazuhiko; Sakurai, Takeshi

    2004-01-01

    The Kyoto Protocol, which obliges developed countries to reduce emissions of greenhouse gases (GHG), was adopted at the third session of the conference of the parties to the United Nations Framework Convention on Climate Change (UNFCCC) in Kyoto, Japan, on I I December 1997. Japan subsequently ratified the Kyoto Protocol in 2002 and is required thereunder to reduce GHG emissions by 6% below 1990 levels by 2008-2012. Japan, having already tackled development and promotion of energy conservation technologies after the second oil crisis, emits the lowest level of CO 2 of developed countries approximately 9.4 tons per capita in the year 2000. Consequently, Japan is able to contribute to CO 2 emissions reduction in developing economies as well as in economies in transition by application of Japan's energy conservation technologies. Because the Clean Development Mechanism (CDM) and Joint implementation (JI) of the Kyoto Mechanisms are efficient tools, the Japanese government's policy towards emission reduction makes active use of CDM/JI, thereby supporting domestic efforts in realizing Japan's reduction commitment. The Ministry of Economy, Trade and Industry (METI) of Japan is one of the key ministries to administer Governmental policy making on climate change, and is undertaking establishment of a system to facilitate the Kyoto Mechanisms. The New Energy and Industrial Technology Development Organization (NEDO), under the jurisdiction of METI, supports CDM and JI project activities implemented by Japanese private sector enterprises. In this report, the authors briefly introduce climate change policy measures in Japan and NEDO's activities to promote CDM/Jl. (Author)

  20. Energy diffusion and the butterfly effect in inhomogeneous Sachdev-Ye-Kitaev chains

    Directory of Open Access Journals (Sweden)

    Yingfei Gu, Andrew Lucas, Xiao-Liang Qi

    2017-05-01

    Full Text Available We compute the energy diffusion constant $D$, Lyapunov time $\\tau_{\\text{L}}$ and butterfly velocity $v_{\\text{B}}$ in an inhomogeneous chain of coupled Majorana Sachdev-Ye-Kitaev (SYK models in the large $N$ and strong coupling limit. We find $D\\le v_{\\text{B}}^2 \\tau_{\\text{L}}$ from a combination of analytical and numerical approaches. Our example necessitates the sharpening of postulated transport bounds based on quantum chaos.

  1. LBA-ECO CD-06 Physical, Political, and Hydrologic Maps, Ji-Parana River Basin, Brazil

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: This data set contains physical, hydrologic, political, demographic, and societal maps for the Ji-Parana River Basin, in the state of Rondonia, Brazil....

  2. Effects of Tai Ji Quan training on gait kinematics in older Chinese women with knee osteoarthritis: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Qingguang Zhu

    2016-09-01

    Conclusion: Among older Chinese women with knee OA, a tailored Tai Ji Quan intervention improved gait outcomes. The intervention also improved overall function as indexed by the WOMAC and SPPB. These results support the use of Tai Ji Quan for older Chinese adults with knee OA to both improve their functional mobility and reduce pain symptomatology.

  3. Just-in-time tomography (JiTT): a new concept for image-guided radiation therapy

    International Nuclear Information System (INIS)

    Pang, G; Rowlands, J A

    2005-01-01

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room and guide the radiation therapy treatment. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus it is not adequate for imaging targets with intrafraction motion. In this note, a new approach for image-guided radiation therapy-just-in-time tomography (JiTT)-is proposed. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. (note)

  4. Assessment of waters and sediments impacted by drainage at the Young Dong coal mine site, South Korea.

    Science.gov (United States)

    Woo, Kwangje; Lee, Ju Y; Ji, Won H; Khim, Jeehyeong

    2012-01-01

    This study focused on the assessment of the geochemistry and hydrology of the Imgok Creek-Young Dong tributary for the design of a field coal mine drainage treatment system. Examination of this site showed that the pH was greatly lowered by the addition of the Young Dong water, except in the month of March. The alkalinity was also affected; the concentrations of iron, aluminum, and sulfate were elevated at sites below the confluence; of these, iron was particularly problematic. High iron concentrations were primarily restricted to the acid rock drainage (ARD) (YD-9) water sources, whereas high aluminum concentrations were seen in both the ARD and in some of the upstream water sources. The acidity was primarily due to ferrous and ferric iron with a lesser amount of aluminum acidity. Except for the sampling in March, the flow was dominated by the ARD. This hydrologic condition resulted from the loads of iron, aluminum, sulfate, and acidity, among other constituents, that were dominated by the ARD. Finally, treatment activities should primarily focus on the ARD and specifically seek to remove ferrous and ferric iron from the treatment system.

  5. LBA-ECO CD-06 Physical, Political, and Hydrologic Maps, Ji-Parana River Basin, Brazil

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains physical, hydrologic, political, demographic, and societal maps for the Ji-Parana River Basin, in the state of Rondonia, Brazil. These data...

  6. Severe haze episodes and seriously polluted fog water in Ji'nan, China.

    Science.gov (United States)

    Wang, Xinfeng; Chen, Jianmin; Sun, Jianfeng; Li, Weijun; Yang, Lingxiao; Wen, Liang; Wang, Wenxing; Wang, Xinming; Collett, Jeffrey L; Shi, Yang; Zhang, Qingzhu; Hu, Jingtian; Yao, Lan; Zhu, Yanhong; Sui, Xiao; Sun, Xiaomin; Mellouki, Abdelwahid

    2014-09-15

    Haze episodes often hit urban cities in China recently. Here, we present several continuous haze episodes with extremely high PM2.5 levels that occurred over several weeks in early 2013 and extended across most parts of the northern and eastern China-far exceeding the Beijing-Tianjin-Hebei region. Particularly, the haze episode covered ~1 million km(2) on January 14, 2013 and the daily averaged PM2.5 concentration exceeded 360 μg m(-3) in Ji'nan. The observed maximum hourly PM2.5 concentration in urban Ji'nan reached 701 μg m(-3) at 7:00 am (local time) in January 30. During these haze episodes, several fog events happened and the concurrent fog water was found to be seriously polluted. For the fog water collected in Ji'nan from 10:00 pm in January 14 to 11:00 am in January 15, sulfate, nitrate, and ammonium were the major ions with concentrations of 1.54 × 10(6), 8.98 × 10(5), and 1.75 × 10(6) μeq L(-1), respectively, leading to a low in-situ pH of 3.30. The sulfate content in the fog sample was more than 544 times as high as those observed in other areas. With examination of the simultaneously observed data on PM2.5 and its chemical composition, the fog played a role in scavenging and removing fine particles from the atmosphere during haze episodes and thus was seriously contaminated. However, the effect was not sufficient to obviously cleanse air pollution and block haze episodes. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Nanobiomaterials development and applications

    CERN Document Server

    Papaefthymiou-Davis, Georgia C

    2013-01-01

    Nanomaterials in Nanobiotechnologies: Preparation, Characterization, and ApplicationsBio-Inspired Magnetic NanoparticlesGeorgia C. Papaefthymiou and Eamonn DevlinNanoparticles for BioimagingHye Sun Park and Yong Taik LimBiomedical Applications of Dendrimer Porphyrin or PhthalocyanineWoo-Dong Jang and Won-Gun KohPolymeric Nanoparticles in Cancer TherapyHeebeom Koo, Ji Young Yhee, Ick Chan Kwon, Kwangmeyung Kim, and Ramesh SubbiahCarbon Nanotube BioconjugatesMonica Samal, Dong Kee Yi, and Shashadhar SamalBiocatalytic NanosystemsJaehong Lim and Su Seong LeeMagnetically Induced Hyperthermia for Biomedical ApplicationsMichael Fardis, Ioannis Rabias, Georgios Diamantopoulos, Eleni Karakosta, Danai Tsitrouli, Vassilios Tzitzios, and Georgios PapavassiliouSoft Block Nanobuilding: New Preparation Routes of Soft Nanomaterials Using BiomoleculesEngineered Biomolecules as NanomaterialsYun Jung Lee and Ki Tae NamNanomaterials and Bio-MEMS: Nano- and Microscale Hybridization of Materials and ApplicationsMicrofluidic-Based ...

  8. Analysis of poultry eating and drinking behavior by software eYeNamic

    OpenAIRE

    A. De Montis; A. Pinna; M. Barra; E. Vranken

    2013-01-01

    Constant presence of at least one operator in livestock buildings for broilers would allow a perfect control of animal behaviour and, especially, deviations in feeding and drinking patterns, in the perspective of a high welfare status. However, as nowadays it is impossible for a farmer to be present in the farm all day long, automatic monitoring systems are required. The purpose of this paper is to introduce a system (eYeNamic) for automatic monitoring and analyzing broilers’ behavior in a fa...

  9. Just-in-time tomography (JiTT): a new concept for image-guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Pang, G; Rowlands, J A [Toronto-Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto M4N 3M5 (Canada); Imaging Research, Sunnybrook and Women' s College Health Sciences Centre, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto (Canada)

    2005-11-07

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room and guide the radiation therapy treatment. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus it is not adequate for imaging targets with intrafraction motion. In this note, a new approach for image-guided radiation therapy-just-in-time tomography (JiTT)-is proposed. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. (note)

  10. Tai Ji Quan and global cognitive function in older adults with cognitive impairment: a pilot study.

    Science.gov (United States)

    Li, Fuzhong; Harmer, Peter; Liu, Yu; Chou, Li-Shan

    2014-01-01

    This study evaluated whether Tai Ji Quan: Moving for Better Balance (TJQMBB) could improve global cognitive function in older adults with cognitive impairment. Using a nonrandomized control group pretest-posttest design, participants aged ≥65 years who scored between 20 and 25 on the Mini-Mental State Examination (MMSE) were allocated into either a 14-week TJQMBB program (n=22) or a control group (n=24). The primary outcome was MMSE as a measure of global cognitive function with secondary outcomes of 50-ft speed walk, Timed Up&Go, and Activities-Specific Balance Confidence (ABC) scale. At 14 weeks, Tai Ji Quan participants showed significant improvement on MMSE (mean=2.26, pJi Quan participants performed significantly better compared to the controls in both physical performance and balance efficacy measures (p<0.05). Improvement in cognition as measured by MMSE was related to improved physical performance and balance efficacy. These results provide preliminary evidence of the utility of the TJQMBB program to promote cognitive function in older adults in addition to physical benefits. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  11. Vehicle driving cycle performance of the spark-less di-ji hydrogen engine

    Energy Technology Data Exchange (ETDEWEB)

    Boretti, Alberto A. [School of Science and Engineering, University of Ballarat, PO Box663, Ballarat, VIC 3353 (Australia)

    2010-05-15

    The paper describes coupled CFD combustion simulations and CAE engine performance computations to describe the operation over the full range of load and speed of an always lean burn, Direct Injection Jet Ignition (DI-JI) hydrogen engine. Jet ignition pre-chambers and direct injection are enablers of high efficiencies and load control by quantity of fuel injected. Towards the end of the compression stroke, a small quantity of hydrogen is injected within the spark-less pre-chamber of the DI-JI engine, where it mixes with the air entering from the main chamber and auto-ignites because of the high temperature of the hot glow plug. Then, jets of partially combusted hot gases enter the main chamber igniting there in the bulk, over multiple ignition points, lean stratified mixtures of air and fuel. Engine maps of brake specific fuel consumption vs. speed and brake mean effective pressure are computed first. CAE vehicle simulations are finally performed evaluating the fuel consumption over emission cycles of a vehicle equipped with this engine. (author)

  12. Multifunctional Poly(2,5-benzimidazole)/Carbon Nanotube Composite Films

    Science.gov (United States)

    2010-01-01

    Multifunctional Poly(2,5- benzimidazole )/Carbon Nanotube Composite Films JI-YE KANG,1 SOO-MI EO,1 IN-YUP JEON,1 YEONG SUK CHOI,2 LOON-SENG TAN,3 JONG...molecular-weight poly(2,5- benzimidazole ) (ABPBI). ABPBI/carbon nanotube (CNT) compo- sites were prepared via in situ polymerization of the AB-monomer in the...polymerization; multiwalled carbon nanotube (MWCNT); nano- composites; poly(2,5- benzimidazole ); (ABPBI); polycondensa- tion; poly(phosphoric acid); single-walled

  13. A pilot study of JI-101, an inhibitor of VEGFR-2, PDGFR-β, and EphB4 receptors, in combination with everolimus and as a single agent in an ovarian cancer expansion cohort.

    Science.gov (United States)

    Werner, Theresa L; Wade, Mark L; Agarwal, Neeraj; Boucher, Kenneth; Patel, Jesal; Luebke, Aaron; Sharma, Sunil

    2015-12-01

    JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). None of the currently approved angiogenesis inhibitors have been reported to inhibit EphB4, and therefore, JI-101 has a novel mechanism of action. We conducted a pilot trial to assess the pharmacokinetics (PK), tolerability, and efficacy of JI-101 in combination with everolimus in advanced cancers, and pharmacodynamics (PD), tolerability, and efficacy of JI-101 in ovarian cancer. This was the first clinical study assessing anti-tumor activity of JI-101 in a combinatorial regimen. In the PK cohort, four patients received single agent 10 mg everolimus on day 1, 10 mg everolimus and 200 mg JI-101 combination on day 8, and single agent 200 mg JI-101 on day 15. In the PD cohort, eleven patients received single agent JI-101 at 200 mg twice daily for 28 day treatment cycles. JI-101 was well tolerated as a single agent and in combination with everolimus. No serious adverse events were observed. Common adverse events were hypertension, nausea, and abdominal pain. JI-101 increased exposure of everolimus by approximately 22%, suggestive of drug-drug interaction. The majority of patients had stable disease at their first set of restaging scans (two months), although no patients demonstrated a response to the drug per RECIST criteria. The novel mechanism of action of JI-101 is promising in ovarian cancer treatment and further prospective studies of this agent may be pursued in a less refractory patient population or in combination with cytotoxic chemotherapy.

  14. Study on embodied CO2 transfer between the Jing-Jin-Ji region and other regions in China: a quantification using an interregional input-output model.

    Science.gov (United States)

    Chen, Mengmeng; Wu, Sanmang; Lei, Yalin; Li, Shantong

    2018-03-08

    Jing-Jin-Ji region (i.e., Beijing, Tianjin, and Hebei) is China's key development region, but it is also the leading and most serious air pollution region in China. High fossil fuel consumption is the major source of both carbon dioxide (CO 2 ) emissions and air pollutants. Therefore, it is important to reveal the source of CO 2 emissions to control the air pollution in the Jing-Jin-Ji region. In this study, an interregional input-output model was applied to quantitatively estimate the embodied CO 2 transfer between Jing-Jin-Ji region and other region in China using China's interregional input-output data in 2010. The results indicated that there was a significant difference in the production-based CO 2 emissions in China, and furthermore, the Jing-Jin-Ji region and its surrounding regions were the main regions of the production-based CO 2 emissions in China. Hebei Province exported a large amount of embodied CO 2 to meet the investment, consumption, and export demands of Beijing and Tianjin. The Jing-Jin-Ji regions exported a great deal of embodied CO 2 to the coastal provinces of southeast China and imported it from neighboring provinces.

  15. Düzce Orman Ürünleri Sanayi İşletmelerinin Yeşil Pazarlama Konusunda Tutum ve Davranışlarının İncelenmesi

    Directory of Open Access Journals (Sweden)

    Tarık GEDİK

    2015-06-01

    Full Text Available Gelişen teknoloji ile birlikte çevrenin korunmasına verilen önem giderek artmaktadır. Hem bireysel hem de sivil toplum örgütlerinin çevreye karşı duyarlılığının günden güne artması sonucunda üretici konumunda bulunan işletmeler rakiplerinin önüne geçmek için çevreye daha fazla önem verdiklerini faaliyetlerinde tüketicilere yansıtmak istemektedirler. Bu bağlamda işletmelerin yeşil pazarlama kavramına olan ilgileri de günden güne artış göstermektedir. Yapılan bu çalışma Düzce orman ürünleri sanayi işletmelerinin yeşil pazarlama konusunda tutum ve davranışlarını belirlemeye yönelik bir araştırma niteliğindedir. Bu amaç doğrultusunda Ocak-Nisan 2014 döneminde Düzce ilinde Düzce Ticaret ve Sanayi Odasına Kayıtlı 66 orman endüstri işletmesinin anket yardımıyla incelenmesi hedeflenmiştir. İnceleme sonucunda yapılan istatitiksel analizlerle yeşil pazarlama konusunda Düzce orman ürünleri sanayi işletmelerinin yeşil pazarlama kapsamında yaptıkları faaliyetlerle daha yüksek bir tatmine ve müşteri memnuniyetine ulaştıkları belirlenmiştir. Yeşil pazarlama kapsamında işletmelerin daha fazla sorumluluk almaları gerektiği ve bunun sonucunda da daha yüksek finansmana gereksinim duydukları belirtilirken, işletmelerin yeşil pazarlamaya verecekleri önemle güvenilirliklerini arttıracağı görülmüştür.

  16. A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients

    Science.gov (United States)

    Lo, Hui-Chen; Hsieh, Chienyan; Lin, Fang-Yi; Hsu, Tai-Hao

    2013-01-01

    The caterpillar fungus Ophiocordyceps sinensis (syn.† Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either “yartsa gunbu” or “DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo)” (“winter worm-summer grass”), respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as “soft gold” in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of “DongChongXiaCao” is different for O. sinensis, Cordyceps spp.,‡ and Cordyceps spƒ. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin), melanin, lovastatin, γ-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1st, 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name “H. sinensis” has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis. PMID:24716152

  17. A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo and Related Bioactive Ingredients

    Directory of Open Access Journals (Sweden)

    Hui-Chen Lo

    2013-01-01

    Full Text Available The caterpillar fungus Ophiocordyceps sinensis (syn.† Cordyceps sinensis, which was originally used in traditional Tibetan and Chinese medicine, is called either “yartsa gunbu” or “DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo” (“winter worm-summer grass”, respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as “soft gold” in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of “DongChongXiaCao” is different for O. sinensis, Cordyceps spp.,‡ and Cordyceps spƒ. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin, melanin, lovastatin, γ-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1st, 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name “H. sinensis” has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis.

  18. A reality in the infantile education centre Ding-Dong

    Directory of Open Access Journals (Sweden)

    Isabel García-Baquero Urbiola

    2013-05-01

    Full Text Available The infant education centre Ding-Dong since 1983 –that inaugurated its first infant centre– and now at present –with the Quality and Environmental Certification– continues to be faithful to its pedagogical ideology “the future of the social and environmental economy depends on the quality of the education in the first years of life (0-6 years”. This quality needs to be reinforced and complete don a daily basis and advance towards a sustainable management. To elaborate a report of sustainability is without doubt, an excellent reference of quality and gives a wide credibility of the educative centre. The transparency of the sustainability of the activities of the organisations has a priority of interests for a wide range of interested groups, amongst which are included the educative organisations. One of the most important objectives that sustainable development holds is the demand for innovative alternatives and new ways of thinking, something that should be inherent in any entity which dedicates itself to teaching and training. The present article manifests that the management of the sustainable educational centres have to set up the priority objective of any advanced educational policy.

  19. Interprovincial transfer of embodied energy between the Jing-Jin-Ji area and other provinces in China: A quantification using interprovincial input-output model.

    Science.gov (United States)

    Chen, Weiming; Wu, Sanmang; Lei, Yalin; Li, Shantong

    2017-04-15

    Commodity trade between regions implies a large amount of energy transfer. As an important economic growth pole of China, the Jing-Jin-Ji area (Beijing-Tianjin-Hebei) is also one of the areas with the largest energy consumption in China. Moreover, the primary energy consumer goods in this area are fossil fuels, such as coal. This has led to serious air pollution in the area. Therefore, the reduction of energy consumption under the premise of maintaining sustained economic growth is an important task of the Jing-Jin-Ji area. In this study, an interprovincial input-output model was applied to quantitatively estimate the embodied energy transfer between Jing-Jin-Ji area and other provinces in China. The results indicated that the Metal and nonmetal mineral processing industry and the Electrical, gas and water industry in the Jing-Jin-Ji area exported a large amount of embodied energy to the Yangtze River Delta and the Pearl River Delta. However, the embodied energy export of the Jing-Jin-Ji area mainly exported by Hebei province. Beijing and Tianjin even have some net import of embodied energy. The embodied energy transfer between Tianjin, Hebei and other provinces was mainly driven by investment, while the main media of embodied energy transfer between Beijing and other provinces was consumption. Therefore, we suggest that the Jing-Jin-Ji area should further increase the degree of dependence on other provinces' energy-intensive products and reduce the export of energy-intensive products. In addition, there should be difference in the energy and industrial policies among Beijing, Tianjin and Hebei, and the problems of high energy consumption and high proportion of heavy industry in Hebei should be first resolved. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Effect of Tai Ji Quan training on self-reported sleep quality in elderly Chinese women with knee osteoarthritis: a randomized controlled trail.

    Science.gov (United States)

    Lü, Jiaojiao; Huang, Lingyan; Wu, Xie; Fu, Weijie; Liu, Yu

    2017-05-01

    The purpose of this study was to explore the effects of a 24-week Tai Ji Quan training program on sleep quality, quality of life, and physical performance among elderly Chinese women with knee osteoarthritis (OA). A 24-week randomized, controlled trial of 46 elderly women with knee OA. Participants were randomly assigned to either a Tai Ji Quan group (n = 23) or a control group (n = 23). Participants in the Tai Ji Quan group completed training sessions three times per week, while those in the control group had bi-weekly educational classes. The primary outcome was total score of the Pittsburgh Sleep Quality of Index (PSQI). Secondary outcomes were: seven subscales of the PSQI; sleep latency; total sleep time; sleep efficiency; physical component summary (PCS) and mental component summary (MCS) of the 36-item Short Form Health Survey (SF-36); Berg Balance Scale (BBS); and Timed Up and Go (TUG). Compared with the control group, participants in the Tai Ji Quan group had significantly improved primary outcome (global PSQI score, p = 0.006) and secondary outcomes, including three PSQI sub-scores (sleep latency, p = 0.031; sleep duration, p = 0.043; daytime dysfunction, p = 0.007), total sleep time (p = 0.033), and SF-36 PCS (p = 0.006). The Tai Ji Quan group also had significant improvements compared with baseline in three PSQI sub-scores (sleep latency, p = 0.031; habitual sleep efficiency, p = 0.049; sleep disturbance, p = 0.016), sleep latency (p = 0.003), BBS (p = 0.001), and TUG (p = 0.006). Tai Ji Quan training is an effective treatment approach to improve sleep quality and quality of life in elderly Chinese women with knee OA. Chinese Clinical Trial Registry (June 16, 2013): ChiCTR-TRC-13003264. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. [Regional ecological planning and ecological network construction: a case study of "Ji Triangle" Region].

    Science.gov (United States)

    Li, Bo; Han, Zeng-Lin; Tong, Lian-Jun

    2009-05-01

    By the methods of in situ investigation and regional ecological planning, the present ecological environment, ecosystem vulnerability, and ecological environment sensitivity in "Ji Triangle" Region were analyzed, and the ecological network of the study area was constructed. According to the ecological resources abundance degree, ecological recovery, farmland windbreak system, environmental carrying capacity, forestry foundation, and ecosystem integrity, the study area was classified into three regional ecological function ecosystems, i. e., east low hill ecosystem, middle plain ecosystem, and west plain wetland ecosystem. On the basis of marking regional ecological nodes, the regional ecological corridor (Haerbin-Dalian regional axis, Changchun-Jilin, Changchun-Songyuan, Jilin-Songyuan, Jilin-Siping, and Songyuan-Siping transportation corridor) and regional ecological network (one ring, three links, and three belts) were constructed. Taking the requests of regional ecological security into consideration, the ecological environment security system of "Ji Triangle" Region, including regional ecological conservation district, regional ecological restored district, and regional ecological management district, was built.

  2. K jubileu prof. JUDr. Zdeňka Jičínského, DrSc

    Czech Academy of Sciences Publication Activity Database

    Grospič, Jiří

    2009-01-01

    Roč. 148, č. 5 (2009), s. 526-527 ISSN 0231-6625 Institutional research plan: CEZ:AV0Z70680506 Keywords : tribute to Zdeněk Jičínský * Czech lawyer * Czech politican Subject RIV: AG - Legal Sciences

  3. A hydrogeological investigation of the Yeşilyurt (Isparta-Sütçüler plain

    Directory of Open Access Journals (Sweden)

    Suat Taşdelen

    2002-03-01

    Full Text Available Investigation area is almost 10 km in the north-west of Sütçüler country of Isparta and covers 60 km2 area. Firstly, detailed geological and hydrological investigation of Yeşilyurt Plain surface drainage area has been performed. Long term monitoring and analyses have been done for direction of hydrological investigation. An isohiyetal map was prepared for the investigation area. Water table maps were drawn by means of deep and shallow boreholes in the plain and flow direction was determined (October 2000. Water which was collected at boreholes was chemically analyzed to determine the characteristic of water for domestic use, irrigation and industrial purposes. In order to achieve this, the anion and cation concentrations, ionization abilities ionic activity, calcite dolomite sulphate saturation indexes and the partial pressures of dissolved CO2 were calculated and the results were interpreted. In addition, water has been classified according to chemical contend and use purpose by means of Wilcox, USA Salinity Laboratory, Piper and Schoeller diagrams and similarities in the origins of waters were investigated. During the study, a groundwater budget of Yeşilyurt Plain was prepared in the light of obtained data and optimum output of groundwater has been calculated.

  4. Research on the use of environmental isotopes technique for safety assessment of the Dong-mo reservoir

    International Nuclear Information System (INIS)

    Bui Dac Dung; Trinh Van Giap; Le Tien Quan; Dang Anh Minh; Dinh Bich Lieu; Nguyen Manh Hung; Pham Quoc Ky; Ta Hong Duc; Dang Van Lap; Phung Van Luc

    2007-01-01

    To help end-users generate information on the rate and origin of the seepage - leakage water of the sub dam A (FA) of the Dong-mo reservoir we have conducted a research project in the 2005-2006 period. The experiences gained in this project are needed for recommending further use in other reservoirs. The main works were collecting water samples, analyzing for 18 O/ 16 O, 2 H(D)/ 1 H ratios, analyzing for 3 H(T) and chemical contents, then drawing conclusions about the origin of the seepage water and the seepage rate at the dam FA. Findings of the project showed that: a) Waters at the piezometers on the top and the 1st roof are not originated from lake water; b) Waters at the piezometers on 1st and 2nd levels, as well as seepage - leakage waters at the dam toe are mixed of lake and ground waters, and the old river bed could be the channel for ground water upcoming from beneath the dam body; c) The transit times of water from the lake to the observation points are from 3 to 4 months, and the velocity is of about 1.1x10 -3 cm/s; d) The findings from tritium analyses show that all waters around the Dong-mo area are recent waters recharged regularly by meteoric water. Based on the findings of the project we have recommended that the environmental isotope technique be applied for further investigations of origin of leakage and seepage water at other dams. (author)

  5. Evaluating origins and water seepage rates at the subdam A of the Dong Mo reservoir using environmental isotope technique

    International Nuclear Information System (INIS)

    Bui Dac Dung; Trinh Van Giap; Dang Anh Minh; Nguyen Van Hoan

    2008-01-01

    Environmental isotope techniques have been world-widely used for investigating origins and the rates of the seepage - leakage water at reservoir dams. We have conducted a research on the use of environmental isotope techniques for evaluating the origin of the seepage water and the seepage rate at the sub dam A of the Dong Mo reservoir. The main works were collecting water samples, analyzing for 18 O/ 16 O, 2 H(D)/ 1 H ratios, analyzing for 3 H(T) and chemical contents. Findings of the project showed that: a) Waters at the piezometers on the top and the 1st roof are not originated from lake water; b) Waters at the piezometers on 1st and 2nd levels, as well as seepage waters at the dam toe are mixed of lake and ground waters, and the old river bed could be the channel for ground water upcoming from beneath the dam body; c) The transit times of water from the lake to the observation points are from 3 to 4 months, and the seepage velocity is of about 1.1x10 -3 cm/s; d) The findings from tritium analyses show that all waters around the Dong Mo area are recent waters recharged regularly by meteoric water. (author)

  6. Workshop Arboretum Volčji potok

    Directory of Open Access Journals (Sweden)

    Ana Kučan

    2012-01-01

    Full Text Available From its constitution onwards, the Volčji Potok Arboretum has been caught between various conflicting orientations. It is both a scientific, research and educational institution, and a cultural monument with exquisite garden and landscape design features and areas of great natural value and built cultural heritage, as well as commercial venue. At the same time, it functions as a park and an area for mass events, a garden centre and nursery. This variety of functions has helped Arboretum to survive the pressures of time; however, partial and uncoordinated interventions have threatened its original mission and its image and generated a number of conflicting situations. The workshop, organised on the initiative of the Institute for the Protection of Cultural Heritage of Slovenia, which involved students from the Faculty of Architecture and students from the Department of Landscape Architecture of the Biotechnical Faculty in mixed groups, generated eight proposals to solve some of the most urgent problems by introducing optimised development with clearly defined goals and priorities.

  7. Investigation of JI and DI CMOS FXR response at different spectral energies

    International Nuclear Information System (INIS)

    Honnold, V.R.; Goldberg, M.; Schreiner, W.A.; Witteles, A.A.

    1975-01-01

    The transient response of both junction isolated (JI) and dielectrically isolated (DI) CMOS circuits has been investigated in three FXR environments of differing energy spectrums. The offset recovery times have been measured and analyzed for both structures. It is shown that while the DI circuit (HD4007) did not exhibit a four layer type latchup action, its transient response persisted for a time longer than is expected for this type of device. A possible mechanism for this observed response is developed and discussed. JI circuits (CD4007) exposed under the same conditions exhibited four layer device action and one sample at low spectral energies latched-up. The conditions for the latchup to occur including the four layer device paths are discussed. Finally, the dependence of the x-ray transient response on the spectral energy is considered. For the lower energy FXR source, latchup was observed in a CD4007 sample. This latchup was not observed at more than double the dose rate when a high energy FXR was used. This result is attributed to dose enhancement, and a device enhancement factor may also be involved. The dose enhancement factor is estimated from the work of Long, and points up the importance of accounting for the spectral energy content in simulating a given nuclear threat spectrum

  8. [Editing style of Imwon-Gyeongjeji, Inje-ji and inclusion of the medicinal knowledge of the late period of Joseon - Comparing mainly with Dongui-Bogam -].

    Science.gov (United States)

    Jeon, Jongwook; Jo, Changrock

    2012-12-01

    Imwon-Gyeongjeji which was created by Seo Yu-gu in the first half of the 19th century is a encyclopedia of practical use in rural life. It consists of 113 volumes, 16 fields, and 2.52 million total characters. Of these, the field of medicine comes 11th of the contents covering 28 volumes and 1.1 million characters. Its name is Inje-ji. This paper examines the academic background of Seo Yu-gu and his life work briefly, and investigates the characteristics of medical knowledge of late Joseon period contained in the Imwon-Gyeongjeji, Inje-ji Here, we made key comparisons especially with Dongui-Bogam, Joseon's leading medical book. Of the pioneers of medical history studies of Joseon, a Japanese researcher Miki Sakae has made a negative evaluation to Inje-ji. But after concrete investigation we have come to conclude as follows. First, familial ancestors of Seo Yu-gu were engaged in the introduction of foreign-language books, so Seo Yu-gu as an officer of proof-reading and editing of the various books, also had a lot of knowledge on the medical books ever in history. On this background and experience, for over 36 years from 1,806 retirement from official position to his death, he had compiled and edited Imwon-Gyeongjeji. Second, unlike Dongui-Bogam which included improving health skill, Inje-ji focused on curing medicine readily accessible from the major population of that time. Its main features are as follows: i) prescriptions directly linked to the diseases and symptoms, ii) greatly increased medicinal knowledge especially on infectious diseases and trauma, iii) detailed index easy to look up for prescription and iv) his 'own opinions'[an-seol] which can indicate relevant contents within the book and organically combines the whole knowledge in it. Third, "Inje-ji" utilizing medical books in China and Korea even those of Japan, collected more massively almost all the medical knowledge, new illness, herbs of local area, private prescription. Meanwhile Inje-ji modified

  9. Role of Heterotrophic Bacteria in Marine Ecological Processes

    Digital Repository Service at National Institute of Oceanography (India)

    Ramaiah, N.

    radicals (called reactive oxygen species) and ferric ion concentrations are known to exert significant influence on bacterial growth (Koga and Takumi, 1995; Gauthier, 2000; Ji-Dong Gu, Chapter 7). Most of these agents in aquatic environment can cause death... are then developed into the fossil fuels and extracted as oil and gas to drive the world?s economy. The burning of fossil fuel releases large quantities of CO2 into the atmosphere, which may accumulate over time or can be incorporated into plant material...

  10. [Professor DONG Gui-rong's experience for the treatment of peripheral facial paralysis].

    Science.gov (United States)

    Cao, Lian-Ying; Shen, Te-Li; Zhang, Wei; Chen, Si-Hui

    2012-05-01

    Professor DONG Gui-rong's theoretical principle and manipulation points for peripheral facial paralysis were introduced in details from the angels of syndrome differentiation, timing, acupoint prescription and needling methods. For the syndrome differentiation and timing, the professor emphasized to check the treatment timing and follow the symptoms, which should be treated by stages, besides, it was necessary to find and distinguish the reason and nature of diseases to have a combined treatment of tendons and muscles. For the acupoint prescription and needling methods, he has proposed that the acupoints selection should be compatible of distal and lacal, and made a best of Baihui (GV 20) to regulate the whole yang qi, also he has paid much attention to the needling methods and staging treatment. Under the consideration of late stage of peripheral facial paralysis, based on syndrome differentiation Back-shu points have been selected to regulate zang-fu function, should achieve much better therapeutic effect.

  11. [DONG's extraordinary acupoints for the ovarian function of polycystic ovary syndrome:a randomized controlled pilot trial].

    Science.gov (United States)

    Cao, Yu; Zhang, Li; Zhao, Danyang; Liu, Zhishun

    2017-07-12

    To preliminary assess the efficacy of DONG 's extraordinary acupoints for the ovarian function of polycystic ovary syndrome. Fifty-six patients were randomized into an acupuncture group and a western medication group. In the acupuncture group, the acupoints were Fuke, Huanchao, Tianhuang (Yinlingquan, SP 9), Renhuang (Sanyinjiao, SP 6), Guanyuan (CV 4), Zigong (EX-CA 1). The treatment was used twice a week for continuous 12 weeks. In the western medication group, patients were given diane-35 for 3 menstrual cycles, once a day for 21 days with 7 days between the two sessions. The ratio of luteinizing hormone/flitropin (LH/FSH) was taken as the primary index, while the secondary indices were serum testosterone (T), FSH, LH, body mass index (BMI), the condition of ovary and menstruation. ①After treatment, the ratio of LH/FSH declined in both the two groups ( P 0.05). ②T, LH and BMI dropped in the two groups ( P 0.05). ③The size of ovary did not change significantly after treatment in the two groups (both P >0.05), but the reduction degree of ovary size of the acupuncture group was larger than that of the western medication group ( P ovary number of more than 10 foliiculi in single ovary in the acupuncture group reduced compared with that before treatment ( P ovary number with the above feature was not significantly different between the two groups ( P >0.05). ④The times and days of menstruation within 3 months increased significantly in the two groups (all P 0.05). DONG 's extraordinary acupoints could improve the ovarian function of polycystic ovary syndrome, whose effect is similar as diane-35.

  12. JiTTree: A Just-in-Time Compiled Sparse GPU Volume Data Structure

    KAUST Repository

    Labschutz, Matthias

    2015-08-12

    Sparse volume data structures enable the efficient representation of large but sparse volumes in GPU memory for computation and visualization. However, the choice of a specific data structure for a given data set depends on several factors, such as the memory budget, the sparsity of the data, and data access patterns. In general, there is no single optimal sparse data structure, but a set of several candidates with individual strengths and drawbacks. One solution to this problem are hybrid data structures which locally adapt themselves to the sparsity. However, they typically suffer from increased traversal overhead which limits their utility in many applications. This paper presents JiTTree, a novel sparse hybrid volume data structure that uses just-in-time compilation to overcome these problems. By combining multiple sparse data structures and reducing traversal overhead we leverage their individual advantages. We demonstrate that hybrid data structures adapt well to a large range of data sets. They are especially superior to other sparse data structures for data sets that locally vary in sparsity. Possible optimization criteria are memory, performance and a combination thereof. Through just-in-time (JIT) compilation, JiTTree reduces the traversal overhead of the resulting optimal data structure. As a result, our hybrid volume data structure enables efficient computations on the GPU, while being superior in terms of memory usage when compared to non-hybrid data structures.

  13. JiTTree: A Just-in-Time Compiled Sparse GPU Volume Data Structure

    KAUST Repository

    Labschutz, Matthias; Bruckner, Stefan; Groller, M. Eduard; Hadwiger, Markus; Rautek, Peter

    2015-01-01

    Sparse volume data structures enable the efficient representation of large but sparse volumes in GPU memory for computation and visualization. However, the choice of a specific data structure for a given data set depends on several factors, such as the memory budget, the sparsity of the data, and data access patterns. In general, there is no single optimal sparse data structure, but a set of several candidates with individual strengths and drawbacks. One solution to this problem are hybrid data structures which locally adapt themselves to the sparsity. However, they typically suffer from increased traversal overhead which limits their utility in many applications. This paper presents JiTTree, a novel sparse hybrid volume data structure that uses just-in-time compilation to overcome these problems. By combining multiple sparse data structures and reducing traversal overhead we leverage their individual advantages. We demonstrate that hybrid data structures adapt well to a large range of data sets. They are especially superior to other sparse data structures for data sets that locally vary in sparsity. Possible optimization criteria are memory, performance and a combination thereof. Through just-in-time (JIT) compilation, JiTTree reduces the traversal overhead of the resulting optimal data structure. As a result, our hybrid volume data structure enables efficient computations on the GPU, while being superior in terms of memory usage when compared to non-hybrid data structures.

  14. JiTTree: A Just-in-Time Compiled Sparse GPU Volume Data Structure.

    Science.gov (United States)

    Labschütz, Matthias; Bruckner, Stefan; Gröller, M Eduard; Hadwiger, Markus; Rautek, Peter

    2016-01-01

    Sparse volume data structures enable the efficient representation of large but sparse volumes in GPU memory for computation and visualization. However, the choice of a specific data structure for a given data set depends on several factors, such as the memory budget, the sparsity of the data, and data access patterns. In general, there is no single optimal sparse data structure, but a set of several candidates with individual strengths and drawbacks. One solution to this problem are hybrid data structures which locally adapt themselves to the sparsity. However, they typically suffer from increased traversal overhead which limits their utility in many applications. This paper presents JiTTree, a novel sparse hybrid volume data structure that uses just-in-time compilation to overcome these problems. By combining multiple sparse data structures and reducing traversal overhead we leverage their individual advantages. We demonstrate that hybrid data structures adapt well to a large range of data sets. They are especially superior to other sparse data structures for data sets that locally vary in sparsity. Possible optimization criteria are memory, performance and a combination thereof. Through just-in-time (JIT) compilation, JiTTree reduces the traversal overhead of the resulting optimal data structure. As a result, our hybrid volume data structure enables efficient computations on the GPU, while being superior in terms of memory usage when compared to non-hybrid data structures.

  15. Completion of cathode strip chamber (CSC) installation on the so-called YE+2 wheel of CMS on March 2005.

    CERN Multimedia

    Tejinder S. Virdee

    2005-01-01

    The pictures have been taken in the CMS construction hall in Cessy (neighbouring France), called SX5, in March 2005 and show the status of cathode strip chamber (CSC) assembly on the yoke disk YE+2. The chambers are labelled ME+3 and their installation has been completed on March 16th, 2005.

  16. Paclitaxel-loaded poly(glycolide-co-ε-caprolactone-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles for lung cancer therapy

    Directory of Open Access Journals (Sweden)

    Zhao TJ

    2013-05-01

    Full Text Available Tiejun Zhao,1 Hezhong Chen,1 Yuchao Dong,2 Jiajun Zhang,1 Haidong Huang,2 Ji Zhu,1 Wei Zhang21Institute of Cardiothoracic Surgery, 2Respiratory Department, Changhai Hospital, Shanghai, People's Republic of ChinaAbstract: In order to improve the therapeutic efficacy and minimize the side effects of lung cancer chemotherapy, the formulation of paclitaxel-loaded poly(glycolide-co-ε-caprolactone-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles (PTX-loaded [PGA-co-PCL]-b-TPGS2k NPs was prepared. The novel amphiphilic copolymer (PGA-co-PCL-b-TPGS2k was synthesized by ring-opening polymerization and characterized by proton nuclear magnetic resonance spectroscopy and gel permeation chromatography. The PTX-loaded (PGA-co-PCL-b -TPGS2k NPs were characterized in terms of size, size distribution, zeta potential, drug encapsulation, surface morphology, and drug release. In vitro cellular uptakes of NPs were investigated with confocal laser scanning microscopy, indicating the coumarin 6-loaded (PGA-co-PCL-b -TPGS2k NPs could be internalized by human lung cancer A-549 cells. The antitumor effect of PTX-loaded NPs was evaluated, both in vitro and in vivo, on an A-549 cell tumor-bearing mouse model via intratumoral injection. The commercial PTX formulation Taxol was chosen as the reference. Experimental results showed that the PTX-loaded NPs possessed higher cytotoxicity and could effectively inhibit the growth of tumor. All the results suggested that amphiphilic copolymer (PGA-co-PCL-b -TPGS2k could act as a potential biological material for nanoformulation in the treatment of lung cancer.Keywords: (PGA-co-PCL-b TPGS2k, paclitaxel, nanoparticles, drug delivery, lung cancer

  17. Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

    OpenAIRE

    Zhao,JiHui; Zhang,Qi-Bo; Liu,Bao; Piao,Xiang-Hua; Yan,Yu-Lu; Hu,Xiao-Ge; Zhou,Kuan; Zhang,Yong-Tai; Feng,Nian-Ping

    2017-01-01

    Ji-Hui Zhao,1,* Qi-Bo Zhang,1,* Bao Liu,2 Xiang-Hua Piao,1 Yu-Lu Yan,1 Xiao-Ge Hu,1 Kuan Zhou,1 Yong-Tai Zhang,1 Nian-Ping Feng1 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Anethesiology Department, Augusta University, Augusta, GA, USA *These authors contributed equally to this work Purpose: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a ...

  18. The Measurement of Urbanization Level Based on Entity Space: A Case Study of JingJinJi Region, China

    Directory of Open Access Journals (Sweden)

    Wen Fenghua

    2017-01-01

    Full Text Available On the basis of analyzing the pros and cons of different urbanization level measurement methods, this paper puts forward urbanization level measurement method based on entity space and then uses entity space data to describe the urbanization rate of various districts and counties of JingJinJi Region in 2005 and 2009. According to the analysis of time and space differences on such basis, JingJinJi may be divided from high to low order according to the urbanization rate of the entity space: central urban area, urban development area and suburb, which respectively bear different functions. According to the comparison of entity space urbanization rate and population urbanization rate in the aspects of sequence, primacy ratio, zipf index, etc., we find the non-intensive land use status quo of urban development area of JingJinJi and the feature that the distribution of entity space urbanization scale is much uniform than distribution of population urbanization scale. Accordingly, the paper puts forward the following suggestions : (1 The space construction should depend upon function division; (2 The urban development area should pay attention to the construction of the supporting facilities and meanwhile enhance land use rate; (3 The urban construction should be enhanced in small and middle regions and counties surrounding Beijing and Tianjin.

  19. IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia

    Directory of Open Access Journals (Sweden)

    Zhang JJ

    2017-08-01

    Full Text Available Jingjing Zhang,1,* Qing Ji,2,* Chunhua Jiao,3,* Lihua Ren,4 Ye Zhao,4 Yanfang Chen,4 Ruihua Shi,4 Yadong Feng4 1State Key Laboratory of Reproductive Medicine, Department of Prenatal Diagnosis, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 2Department of Emergency, Jingjiang People’s Hospital, Jingjiang, 3Department of Gastroenterology, First Affiliated Hospital with Nanjing Medical University, 4Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3 in esophageal high-grade intraepithelial neoplasia (HGIN is not clear. This study was designed to characterize the expression of IGF2BP3 in HGIN. Patients and methods: IGF2BP3 expression was evaluated by Western blot analyses in 12 cases and by immunohistochemistry (IHC in 112 cases. The associations between IGF2BP3 expression in HGIN and the clinicopathological parameters were examined. Results: Moderate to strong IGF2BP3 expression was present in HGIN samples. Using IHC, it was found that IGF2BP3 was positive in 68 (60.71% cases. Intense IHC of IGF2BP3 in HGIN was associated with a deeper lesion depth, and the lesion depth was the only predictor of the positive expression of IGF2BP3. Conclusion: Our results suggested that IGF2BP3 may be a supplementary tissue marker for preoperative diagnosis of HGIN. Keywords: esophageal squamous cell carcinoma, precancerous lesion, immunohistochemistry detection, early diagnosis

  20. Ultra high performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry for the rapid analysis of constituents in the traditional Chinese medicine formula Wu Ji Bai Feng Pill.

    Science.gov (United States)

    Duan, Shengnan; Qi, Wen; Zhang, Siwen; Huang, Kunkun; Yuan, Dan

    2017-10-01

    An ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in both positive and negative ion modes was established in order to comprehensively investigate the major constituents in Wu Ji Bai Feng Pill. Briefly, a Waters ACQUITY UPLC HSS C 18 column was used to separate the aqueous extract of Wu Ji Bai Feng Pill. A total of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid v/v were used as the mobile phase. All analytes were determined using quadrupole time-of-flight mass spectrometry with electrospray ionization source in positive and negative ion modes. At length, a total of 173 components including flavones and their glycosides, monoterpene glycosides, triterpene saponins, phenethylalchohol glycosides, iridoid glycosides, phthalides, tanshinones, phenolic acids, sesquiterpenoids and cyclopeptides were identified or tentatively characterized in Wu Ji Bai Feng Pill in an analysis of 16.0 min based on the accurate mass and tandem mass spectrometry behaviors. The developed method is rapid and highly sensitive to characterize the chemical constituents of Wu Ji Bai Feng Pill, which could not only be used for chemical standardization and quality control of Wu Ji Bai Feng Pill, but also be helpful for further study in vivo metabolism of Wu Ji Bai Feng Pill. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Dispersive Sachdev-Ye-Kitaev model: Band structure and quantum chaos

    Science.gov (United States)

    Zhang, Pengfei

    2017-11-01

    The Sachdev-Ye-Kitaev (SYK) model is a concrete model for a non-Fermi liquid with maximally chaotic behavior in (0 +1 ) dimensions. In order to gain some insights into real materials in higher dimensions where fermions could hop between different sites, here we consider coupling a SYK lattice by constant hopping. We call this the dispersive SYK model. Focusing on (1 +1 ) -dimensional homogeneous hopping, by either tuning the temperature or the relative strength of the random interaction (hopping) and constant hopping, we find a crossover between a dispersive metal to an incoherent metal, where the dynamic exponent z changes from 1 to ∞ . We study the crossover by calculating the spectral function, charge density correlator, and the Lyapunov exponent. We further find the Lyapunov exponent becomes larger when the chemical potential is tuned to approach a van Hove singularity because of the large density of states near the Fermi surface. The effect of the topological nontrivial bands is also discussed.

  2. The Influence of Romanticism on Mirzade-ye-eshgi’s Artistic Products

    Directory of Open Access Journals (Sweden)

    Fatemeh Moddaresi

    2012-11-01

    Full Text Available Abstract Romanticism is a literarily movement which in last years of 18 the century , derived from England and changed to literally school in 19 century reaching most of the European countries, western Europe and even Russia. This school has deeply in flounced on different aspects of literature in different parts of the world. Romanticism school pierced into Iranian literature, when Iranian poets and writers got introduced with western literature. “ mirzade-ye-eshgi” is one of those poets who we can cleanly see the effects of romanticism school in his poems, since the value of this literarily products owes to romanticism school elements. Revolutionary, creativity, Retiring idealism flash backs to traditional literarily forms national emotions nostalgia creating atmospheres full of sadness and showing sympathy toward the poor, are ports of romanticism school in fluencies on his poems.

  3. Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhu

    2009-01-01

    @@ Respected leaders, distinguished guests, venerable seniors and comrades, Today, the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

  4. A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor.

    Science.gov (United States)

    Gurav, Sandip Dhondiram; Jeniffer, Sherine; Punde, Ravindra; Gilibili, Ravindranath Reddy; Giri, Sanjeev; Srinivas, Nuggehally R; Mullangi, Ramesh

    2012-04-01

    A general practice in bioanalysis is that, whatever the biological matrix the analyte is being quantified in, the validation is performed in the same matrix as per regulatory guidelines. In this paper, we are presenting the applicability of a validated LC-MS/MS method in rat plasma for JI-101, to estimate the concentrations of JI-101 in various tissues that were harvested in a rat tissue distribution study. A simple protein precipitation technique was used to extract JI-101 and internal standard from the tissue homogenates. The recovery of JI-101 in all the matrices was found to be >70%. Chromatographic separation was achieved using a binary gradient using mobile phase A (acetonitrile) and B (0.2% formic acid in water) at a flow rate of 0.30 mL/min on a Prodigy ODS column with a total run time of 4.0 min. The MS/MS ion transitions monitored were 466.1 → 265 for JI-101 and 180.1 → 110.1 for internal standard. The linearity range was 5.02-4017 ng/mL. The JI-101 levels were quantifiable in the various tissue samples harvested in this study. Therefore, the use of a previously validated JI-101 assay in plasma circumvented the tedious process of method development/validation in various tissue matrices. Copyright © 2011 John Wiley & Sons, Ltd.

  5. Social Functions of Ritual Music of Dong Funeral Ceremony%侗族丧葬仪式音乐的社会功能探析--以黔东南黎平县龙额村为例

    Institute of Scientific and Technical Information of China (English)

    姚仕秀

    2014-01-01

    侗族丧葬仪式是侗族人民的一项重要人生仪礼,它的内容和形式与侗族人民的宗教信仰观念有着密切关系,反映了侗族社会的民间传统习俗文化。仪式音乐作为丧葬仪式的组成部分,在仪式过程中担负着不同类型的角色,有赞颂亡者功德、沟通人神对话等媒介的作用。解读龙额侗族丧葬仪式音乐文化,分析其文化内涵及社会功能,对了解和研究侗族丧葬仪式特征,具有重要的价值和意义。%The funeral ceremony of Dong is an important ritual for Dong people. There is a close relationship between its religious concepts and its form and content, reflecting the traditional customs and culture of Dong. As a part of the funeral ceremony, the ritual music plays a different type of roles in it:praising the dead, and communicating with God, and so on. This paper studies the culture of its funeral music and analyzes its cultural conno-tations and social functions for better understanding characteristics of the Dong funeral ceremony, which has important value and significance.

  6. KEYNESYEN TEORİ’YE BİR TEPKİ: ARZ YANLI İKTİSAT

    OpenAIRE

    DOĞAN, Seyhun

    2006-01-01

    Arz Yanlı İktisat, Keynesyen Teori’ye bir tepki olarak 1970’li yıllarda doğmuştur. Arz Yanlı İktisat uygulamaları, 1980’lerde ABD Başkanı R. Reagan ve İngiltere Başbakanı M. Thatcher tarafından ön plana çıkartılmıştır. Özellikle ABD’de büyük ilgi gören Arz Yanlı İktisat, Başkan Reagan’ın seçim programına temel oluşturmuştur. Bu nedenle arz yanlı politikalara, “Reaganomics” ve “Thatcherism” adı da verilmiştir. Ekonominin verimlilik kapasitesi üzerinde etkili olan unsurları inceleyen ve temel a...

  7. Validation of the YuWell YE690A upper-arm blood pressure monitor, for clinic use and self-measurement, according to the European Society of Hypertension International Protocol revision 2010.

    Science.gov (United States)

    Chen, Qi; Lei, Lei; Li, Yan; Wang, Ji-Guang

    2017-10-01

    The present study aimed to evaluate the accuracy of the automated oscillometric upper-arm blood pressure monitor YuWell YE690A for blood pressure measurement according to the International Protocol of the European Society of Hypertension revision 2010. Systolic and diastolic blood pressures were measured sequentially in 33 adult Chinese (12 women, 44.2 years of mean age) using a mercury sphygmomanometer (two observers) and the YE690A device (one supervisor). A total of 99 pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases. All the blood pressure requirements were fulfilled. The YuWell YE690A device achieved the targets in part 1 of the validation study. The number of absolute differences between device and observers within 5, 10, and 15 mmHg was 79/99, 96/99, and 97/99, respectively, for systolic blood pressure and 72/99, 95/99, and 98/99, respectively, for diastolic blood pressure. The device also fulfilled the criteria in part 2 of the validation study. Thirty-one and 25 participants for systolic and diastolic blood pressure, respectively, had at least two of the three device-observer differences within 5 mmHg (required ≥24). No participant for systolic and two participants for diastolic blood pressure had all the three device-observer comparisons greater than 5 mmHg. The YuWell blood pressure monitor YE690A has passed the requirements of the International Protocol revision 2010 and hence can be recommended for blood pressure measurement in adults.

  8. The Impact of Land Use and Land Cover Change on Water Yield in the Jing- Jin-Ji Region in China

    Science.gov (United States)

    Li, Suxiao; Yang, Hong

    2017-04-01

    Water yield is one of the key ecosystem services sustaining both people's life and economic development. However, the water yield function is sensitive to anthropogenic activity especially the land use and land cover change (LUCC). Assessment of historical LUCC and its impact on water yield could benefit designing and implementing appropriate land use strategy that enhance the water yield capacity. Beijing (Jing) and its surrounding areas of Tianjin (Jin) and Hebei (Ji) is the political, cultural and economic center of China. The region is facing increasingly water crisis. Taking the Jing-Jin-Ji region as a study area, this study analyzed the historical LUCC and its impact on water yield by using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model to spatially map and quantify the changes of water yield from 1995 to 2010. The results showed there was main decline in area of wetland and forest and increase in area of crop land and built up land. An abrupt decline in water yield was found for year 2000. The water yield was influenced to a great extent by precipitation and evapotranspiration, but the land use played an important role in the water yield capacity (water yield per unit area) through plant cover that affected evapotranspiration, soil water permeability and the capacity of holding the moisture content. By general ranking, the water yield capacity of different land use type was as follows: built-up>bare land>cropland> grassland>forest >wetland, which illustrated that the built-up and bare land had higher run off rate while the vegetation area had higher capacity to control surface run off to increase the groundwater. A good understanding of temporal-spatial allocation of historical LUCC and Water yield of the Jing-Jin-Ji region could help guide land use policy decisions that take into consideration of tradeoffs with respect to spatial distribution of ecosystem services amongst the three administrative entities (Jing-Jin-Ji) and

  9. Zhen gan xi feng decoction, a traditional chinese herbal formula, for the treatment of essential hypertension: a systematic review of randomized controlled trials.

    Science.gov (United States)

    Xiong, Xingjiang; Yang, Xiaochen; Feng, Bo; Liu, Wei; Duan, Lian; Gao, Ao; Li, Haixia; Ma, Jizheng; Du, Xinliang; Li, Nan; Wang, Pengqian; Su, Kelei; Chu, Fuyong; Zhang, Guohao; Li, Xiaoke; Wang, Jie

    2013-01-01

    Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of ZGXFD for EH reported in any language, with main outcome measure as blood pressure (BP). Results. Six randomized trials were included. Methodological quality of the trials was evaluated as generally low. Four trials compared prescriptions based on ZGXFD with antihypertensive drugs. Meta-analysis showed that ZGXFD was more effective in BP control and TCM syndrome and symptom differentiation (TCM-SSD) scores than antihypertensive drugs. Two trials compared the combination of modified ZGXFD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed that there is significant beneficial effect on TCM-SSD scores. However, no significant effect on BP was found. The safety of ZGXFD is still uncertain. Conclusions. ZGXFD appears to be effective in improving blood pressure and hypertension-related symptoms for EH. However, the evidence remains weak due to poor methodological quality of the included studies. More rigorous trials are warranted to support their clinical use.

  10. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    Science.gov (United States)

    Zhang, Y. P.; Liu, Yi; Luo, X. B.; Isobe, M.; Yuan, G. L.; Liu, Y. Q.; Hua, Y.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R.

    2014-05-01

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team, Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported.

  11. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y. P., E-mail: zhangyp@swip.ac.cn; Liu, Yi; Yuan, G. L.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R. [Southwestern Institute of Physics, P.O. Box 432, Chengdu 610041 (China); Luo, X. B.; Liu, Y. Q.; Hua, Y. [Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610041 (China); Isobe, M. [National Institute for Fusion Science, 322-6 Oroshi-cho, Toki 509-5259 (Japan)

    2014-05-15

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team , Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported.

  12. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    International Nuclear Information System (INIS)

    Zhang, Y. P.; Liu, Yi; Yuan, G. L.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R.; Luo, X. B.; Liu, Y. Q.; Hua, Y.; Isobe, M.

    2014-01-01

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team , Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported

  13. Occurrence of the Spotted Sea Hare Aplysia dactylomela (Rang 1828, Aplysiidae in the Yeşilovacık Bay, Norteastern Mediterranean Coast of Turkey

    Directory of Open Access Journals (Sweden)

    Deniz Ayas

    2017-10-01

    Full Text Available The first record of the A. dactylomela from the Mediterranean Sea, in the Strait of Sicily waters was reported in 2002 (Trainito, 2003. Some reports of the A. dactylomela are given in the Mediterranean Sea in Table 1. A specimen of spotted sea hare was seen in a rock pool which was covered with algea. It was first recorded from Yeşilovacık Bay in 2017. Previous record of the species was noted in the Hatay coast of Turkey (Çinar et al. 2006. The present rapid communication reported the first record of A. dactylomela from the Yeşilovacık Bay. One specimen of A. dactylomela was photographed at the infralittoral zone of the Bay on 26 March, 2017, at a depth of 1 m in a rock pool togetter with Padina pavonica (Linnaeus and other algea.

  14. β-Catenin promotes cell proliferation, migration, and invasion but induces apoptosis in renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Yang CM

    2017-02-01

    Full Text Available Chun-ming Yang,1 Shan Ji,2 Yan Li,3 Li-ye Fu,3 Tao Jiang,3 Fan-dong Meng31Department of Urology, The First Affiliated Hospital, China Medical University, 2Department of Endocrinology, The Fifth People’s Hospital of Shenyang, 3Department of Biotherapy, Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang, ChinaAbstract: β-Catenin (CTNNB1 gene coding protein is a component of the Wnt signaling pathway that has been shown to play an important role in the formation of certain cancers. Abnormal accumulation of CTNNB1 contributes to most cancers. This research studied the involvement of β-catenin in renal cell carcinoma (RCC cell proliferation, apoptosis, migration, and invasion. Proliferation, cell cycle, and apoptosis were analyzed by using Cell Counting Kit-8 and by flow cytometry. Migration and invasion assays were measured by transwell analysis. Real-time polymerase chain reaction and Western blot analysis were used to detect the expression of CTNNB1, ICAM-1, VCAM-1, CXCR4, and CCL18 in RCC cell lines. It was found that CTNNB1 knockdown inhibited cell proliferation, migration, and invasion and induced apoptosis of A-498 cells. CTNNB1 overexpression promoted cell proliferation, migration, and invasion and inhibited apoptosis of 786-O cells. Moreover, knockdown of CTNNB1 decreased the levels of ICAM-1, VCAM-1, CXCR4, and CCL18 expression, but CTNNB1 overexpression increased the expression of ICAM-1, VCAM-1, CXCR4, and CCL18. Further in vivo tumor formation study in nude mice indicated that inhibition of CTNNB1 delayed the progress of tumor formation through inhibiting PCNA and Ki67 expression. These results indicate that CTNNB1 could act as an oncogene and may serve as a promising therapeutic strategy for RCC.Keywords: kidney cancer, oncogene, β-catenin, survival time, tumor migration-related protein

  15. Návrh marketingové kampaně pro Knihovnu Jiřího Mahena v Brně

    OpenAIRE

    Matějková, Kateřina

    2014-01-01

    Subject of this bachelor thesis is design a marketing campaign to increase competitiveness and attendance in Knihovna Jiřího Mahena in Brno. The thesis describes and explains the issues relating to non-profit organizations, in particular governmental organizations. The theoretical part enlarged on ways to finance non-profit organizations, and customer relationship management. Pursuant to available information are compiled an internal and external analysis, an extensive marketing mix analysis ...

  16. Jiří Procháska (1749-1820): Part 2: "De structura nervorum"-Studies on a Structure of the Nervous System.

    Czech Academy of Sciences Publication Activity Database

    Chvátal, Alexandr

    2015-01-01

    Roč. 24, č. 1 (2015), s. 1-25 ISSN 0964-704X Institutional support: RVO:68378041 Keywords : Jiří Procházka * neuroanatomy * nervous tissue Subject RIV: FH - Neurology Impact factor: 0.529, year: 2015

  17. [Thoughts and methods of study on acupuncture medical history: an example of Mr. MA Ji-Xing].

    Science.gov (United States)

    Yang, Feng; Zhu, Ling

    2014-03-01

    Mr. MA Ji-xing has devoted himself into the study of acupuncture medical history for more than 70 years. As a result, a great work of Zhenjiuxue Tongshi (see text), History of Acupuncture-Moxibustion) has been completed. The author has expensively studied for history of acupuncture medicine in time and space. Base on abundant historical materials, deliberate textual research as well as strategically situated academic view, it is considered as a masterpiece of acupuncture on real significance. It is worthwhile to note that the book has a systematic and profound explanation on Bian-stone therapy, unearthed literature relics of acupuncture, the bronze figure or illustration of acupoint as well as special topics of Japan and Korea acupuncture history. Filled several gaps of the field, and explored some significant new paths of study, it laid the groundwork for the profound study and unscramble of traditional acupuncture theory as well as the investigation of the academic history, which is considered to have a profound and persistent influence. The careful sorting and profound digging of many distinguish thoughts and methods of Mr. MA Ji-xing in the study of acupuncture medical history has significant meaning in references and enlightenment of the future research on acupuncture medical history.

  18. Numerical Modeling of a Jet Ignition Direct Injection (JI DI LPG Engine

    Directory of Open Access Journals (Sweden)

    Albert Boretti

    2017-01-01

    Full Text Available The paper presents indirectly validated simulations of the operation of a LPG engine fitted with Direct Injection (DI and Jet Ignition (JI. It is demonstrated that the engine may have diesel like efficiencies and load control by quantity of fuel injected.  As the liquid propane quickly evaporates after injection in the main chamber, the main chamber mixture may be much closer to stoichiometry than a diesel for a better specific power at low engine speeds. This design also works at the high engine speeds impossible for the diesel, as combustion within the main chamber is controlled by the turbulent mixing rather than the vaporization and diffusion processes of the injected fuel of the diesel. 

  19. The impact of the "Air Pollution Prevention and Control Action Plan" on PM2.5 concentrations in Jing-Jin-Ji region during 2012-2020.

    Science.gov (United States)

    Cai, Siyi; Wang, Yangjun; Zhao, Bin; Wang, Shuxiao; Chang, Xing; Hao, Jiming

    2017-02-15

    In order to cope with heavy haze pollution in China, the Air Pollution Prevention and Control Action Plan including phased goals of the fine particulate matter (PM 2.5 ) was issued in 2013. In this study, China's emission inventories in the baseline 2012 and the future scenarios of 2017 and 2020 have been developed based on this Action Plan. Beijing-Tianjin-Hebei (Jing-Jin-Ji) region, one of the most polluted regions in China, was taken as a case to assess the impact of phased emission control measures on PM 2.5 concentration reduction using WRF-CMAQ model system. With the implementation of the Action Plan, the emissions of sulfur dioxide (SO 2 ), nitrogen oxides (NO X ) , PM 2.5 , non-methane volatile organic compound (NMVOC), and ammonia (NH 3 ) in 2017 will decrease by36%, 31%, 30%,12%, and -10% from the 2012 levels in Jing-Jin-Ji, respectively. In 2020, the emissions of SO 2 , NO X, PM 2.5 , NMVOC, and NH 3 will decrease by 40%, 44%, 40%, 22%, and -3% from the 2012 levels in Jing-Jin-Ji, respectively. Consequently, the ambient annual PM 2.5 concentration under the scenarios of 2017 and 2020 will be 28.3% and 37.8% lower than those in 2012, respectively. The Action Plan provided an effective approach to alleviate PM 2.5 pollution level in Jing-Jin-Ji region. However, emission control of NMVOC and NH 3 should be paid more attention and be strengthened in future. Meanwhile, emission control of NO x , SO 2 , NH 3 and NMVOC synergistically are highly needed in the future because multiple pollutants impact on PM 2.5 and O 3 concentrations nonlinearly. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Genetic analysis in maize foundation parents with mapping population and testcross population: Ye478 carried more favorable alleles and using QTL information could improve foundation parents

    Directory of Open Access Journals (Sweden)

    Yinghong Liu

    2016-09-01

    Full Text Available The development of maize foundation parents is an important part of genetics and breeding research, and applying new genetic information to produce foundation parents has been challenging. In this study, we focused on quantitative trait loci (QTLs and general combining ability (GCA of Ye478, a widely used foundation parent in China. We developed three sets of populations for QTL mapping and to analyze the GCA for some agronomic traits. The assessment of 15 traits resulted in the detection of 251 QTLs in six tested environments, with 119 QTLs identified through a joint analysis across all environments. Further analyses revealed that most favorable alleles for plant type-related traits were from Ye478, and more than half of the favorable alleles for yield-related traits were from R08, another foundation parent used in southwestern China, suggesting that different types of foundation parents carried different favorable alleles. We observed that the GCA for most traits (e.g., plant height and 100-kernel weight was maintained in the inbred lines descended from the foundation parents. Additionally, the continuous improvement in the GCA of the descendants of the foundation parents was consistent with the main trend in maize breeding programs. We identified three significant genomic regions that were highly conserved in three Ye478 descendants, including the stable QTL for plant height. The GCA for the traits in the F7 generation revealed that the QTLs for the given traits per se were affected by additive effects in the same way in different populations.

  1. Quantum state-to-state dynamics for the quenching process of Br(2P1/2) + H2(v(i) = 0, 1, j(i) = 0).

    Science.gov (United States)

    Xie, Changjian; Jiang, Bin; Xie, Daiqian; Sun, Zhigang

    2012-03-21

    Quantum state-to-state dynamics for the quenching process Br((2)P(1/2)) + H(2)(v(i) = 0, 1, j(i) = 0) → Br((2)P(3/2)) + H(2)(v(f), j(f)) has been studied based on two-state model on the recent coupled potential energy surfaces. It was found that the quenching probabilities have some oscillatory structures due to the interference of reflected flux in the Br((2)P(1/2)) + H(2) and Br((2)P(3/2)) + H(2) channels by repulsive potential in the near-resonant electronic-to-vibrational energy transfer process. The final vibrational state resolved integral cross sections were found to be dominated by the quenching process Br((2)P(1/2)) + H(2)(v) → Br((2)P(3/2)) + H(2)(v+1) and the nonadiabatic reaction probabilities for Br((2)P(1/2)) + H(2)(v = 0, 1, j(i) = 0) are quite small, which are consistent with previous theoretical and experimental results. Our calculated total quenching rate constant for Br((2)P(1/2)) + H(2)(v(i) = 0, j(i) = 0) at room temperature is in good agreement with the available experimental data. © 2012 American Institute of Physics

  2. Consumption-based Total Suspended Particulate Matter Emissions in Jing-Jin-Ji Area of China

    Science.gov (United States)

    Yang, S.; Chen, S.; Chen, B.

    2014-12-01

    The highly-industrialized regions in China have been facing a serious problem of haze mainly consisted of total suspended particulate matter (TSPM), which has attracted great attention from the public since it directly impairs human health and clinically increases the risks of various respiratory and pulmonary diseases. In this paper, we set up a multi-regional input-output (MRIO) model to analyze the transferring routes of TSPM emissions between regions through trades. TSPM emission from particulate source regions and sectors are identified by analyzing the embodied TSPM flows through monetary flow and carbon footprint. The track of TSPM from origin to end via consumption activities are also revealed by tracing the product supply chain associated with the TSPM emissions. Beijing-Tianjin-Hebei (Jing-Jin-Ji) as the most industrialized area of China is selected for a case study. The result shows that over 70% of TSPM emissions associated with goods consumed in Beijing and Tianjin occurred outside of their own administrative boundaries, implying that Beijing and Tianjin are net embodied TSPM importers. Meanwhile, 63% of the total TSPM emissions in Hebei Province are resulted from the outside demand, indicating Hebei is a net exporter. In addition, nearly half of TSPM emissions are the by-products related to electricity and heating supply and non-metal mineral products in Jing-Jin-Ji Area. Based on the model results, we provided new insights into establishing systemic strategies and identifying mitigation priorities to stem TSPM emissions in China. Keywords: total suspended particulate matter (TSPM); urban ecosystem modeling; multi-regional input-output (MRIO); China

  3. Research on Park Ji-Won in China%朴趾源研究在中国

    Institute of Scientific and Technical Information of China (English)

    张丽娜

    2012-01-01

    朴趾源研究是韩国古典文学研究的一个热点和重点。总体上看,研究队伍中名家济济,以汉文形式发表的研究成果较多。学界对朴趾源的研究主要集中在其思想、小说创作上,《热河日记》是研究的一个焦点。对于朴趾源诗歌、散文和《燕岩集》的整体研究有所欠缺,全面、系统、客观地研究评价朴趾源在韩国文学史、思想史上的地位的专著尚未出现。%Research on Park Ji-Won is a key and hit of Korean classical literature. On the whole, there are many famous experts in the field and lots of research achievements in Chinese. Academic studies focus on his ideas and novels, of which ReHe Diary is a focus. However, an overall study of his poetries, proses and YanYan Collection is not enough. Comprehensive, systematic and objective works have not yet appeared, which study and assess Park Ji -Won's position in the history of Korean literature and intellectual

  4. Jiří Vacek: Slovanská knihovna – můj osud. Mozaika vzpomínek. Národní knihovna\

    Czech Academy of Sciences Publication Activity Database

    Hašková, Dana

    2017-01-01

    Roč. 86, č. 4 (2017), s. 523-525 ISSN 0037-6736 Institutional support: RVO:68378017 Keywords : Vacek, Jiří * The Slavonic Library * Memories Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  5. EKONOMİK KRİZLER VE TÜRKİYE

    Directory of Open Access Journals (Sweden)

    Mehmet Fatih DARICAN

    2015-01-01

    Full Text Available Dünya ekonomisi yıllardır ekonomik istikrarsızlıklara karşı karşıya gelmiştir. Ekonomik istikrarsızlıklar beraberinde dünya devletlerini etkileyen ekonomik krizler meydana getirmiştir. Bu makalede dünyada yaşanan krizler ve bu krizlerin Türkiye'ye yansıması anlatılmıştır. Türkiye'deki krizlerin bir kısmı kendi içindeki problemlerden kaynaklanmış bir kısmı ise dünyadaki gelişmelerden dolayı ortaya çıkmıştır. Türkiye'deki ortaya çıkan krizler tek nedene bağlamak doğru olmaz. Kimi zaman siyasal nedenlerde kimi zaman arz talep dengesizliğinden bazen de bankaların tutumundan kaynaklanabilir. Bu örnekler ve kriz çeşitleri detaylı bir şekilde makalede yer almaktadır. Türkiye tarihinde bir çok defa darbe görmüş bu darbeler sonunda da kimi zaman krize sürüklenmiştir. Demokratik tutumun olup olmaması da ekonomik krizlerin ortaya çıkmasında etkili bir nedendir. Türkiye ilk ekonomik krizi 1929 Büyük bunalım adı ile anılan dünya çapındaki krizle yaşamış son olarak da 2008 deki küresel krizden etkilenmiştir.

  6. Lider-Üye Etkileşiminin İşgören Performansına Etkisinde Çalışanların Örgütsel Adalet Algılarının Rolü

    Directory of Open Access Journals (Sweden)

    Hakan TURGUT

    2015-09-01

    Full Text Available Bu çalışmanın amacı, lider-üye etkileşiminin çalışanların örgütsel adalet algıları ile performansları üzerindeki etkilerini belirlemek ve örgütsel adaletin, lider-üye etkileşimi ile işgören performansı arasındaki ilişkide aracılık rolünün bulunup bulunmadığını araştırmaktır. Bu amaçla Çorum’da bulunan orta öğretim seviyesindeki 20 farklı okulda görevli 471 öğretmenin katılımı ile bir çalışma yapılmıştır. Araştırma sonucunda; lider üye etkileşiminin, örgütsel adalet boyutlarını (dağıtım, işlemsel, kişilerarası, bilgisel ve işgören performansını, işlemsel, kişilerarası ve bilgisel adaletin de işgören performansını anlamlı ve pozitif yönde etkilediği görülmüş, ayrıca işlemsel, kişilerarası ve bilgisel adaletin lider üye etkileşimi ile işgören performansı ilişkisinde tam aracılık rollerinin bulunduğu belirlenmiştir.

  7. THE EFFECT OF PROBLEM SOLVING LEARNING MODEL BASED JUST IN TIME TEACHING (JiTT ON SCIENCE PROCESS SKILLS (SPS ON STRUCTURE AND FUNCTION OF PLANT TISSUE CONCEPT

    Directory of Open Access Journals (Sweden)

    Resha Maulida

    2017-11-01

    Full Text Available The purpose of this study was to determine the effect of Problem Solving learning model based Just in Time Teaching (JiTT on students' science process skills (SPS on structure and function of plant tissue concept. This research was conducted at State Senior High School in South Tangerang .The research conducted using the quasi-experimental with Nonequivalent pretest-Postest Control Group Design. The samples of this study were 34 students for experimental group and 34 students for the control group. Data was obtained using a process skill test instrument (essai type that has been tested for its validity and reliability. Result of data analysis by ANACOVA, show that there were significant difference of postest between experiment and control group, by controlling the pretest score (F = 4.958; p <0.05. Thus, the problem-solving learning based on JiTT proved to improve students’ SPS. The contribution of this treatment in improving the students’ SPS was 7.2%. This shows that there was effect of problem solving model based JiTT on students’ SPS on the Structure and function of plant tissue concept.

  8. Lowering of the YE+3 endcap disc on 30th November

    CERN Multimedia

    Max Brice, CERN

    2006-01-01

    Gigantic disc of CMS detector travels 100 m under the Earth It's an amazing engineering challenge - the lowering of the first tremendous endcap disc, known as YE+3, of the CMS particle detector slowly and carefully 100 m underground into the experimental cavern. The disc is one of 15 large pieces to make the grand descent. It's a uniquely shaped slice, 16 m high, about 50 cm thick and weighing 400 tonnes. The solid steel structure of the disc forms part of the magnet return yoke and is equipped on both sides with muon chambers. A special gantry crane will lower the element, with just 20 cm of leeway between the edges of the detector and the walls of the shaft. CMS is one of the four main experiments that will take data at the world's highest energy particle accelerator, CERN's Large Hadron Collider (LHC). The LHC is a 27 km circular ring 100 m underground. The CMS detector weighs a total of 12 500 tonnes and is constructed on the surface. Once all of the pieces are fully equipped, lowered underground and re-t...

  9. Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Ren HY

    2016-03-01

    Full Text Available Hai-Yong Ren,1 Yin-Hua Zhang,1,2 Heng-Yuan Li,1 Tao Xie,1 Ling-Ling Sun,1 Ting Zhu,1 Sheng-Dong Wang,1 Zhao-Ming Ye1 1Department of Orthopaedics, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 2The First Department of Orthopaedics, Hospital of Zhejiang General Corps of Armed Police Forces, Jiaxing, People’s Republic of China Background: Hypoxia-inducible factor-1α (HIF-1α plays an important role in tumor progression and metastasis. A number of studies have investigated the association of HIF-1α with prognosis and clinicopathological characteristics of osteosarcoma but yielded inconsistent results.  Method: Systematic computerized searches were performed in PubMed, Embase, and Web of Science databases for relevant original articles. The pooled hazard ratios (HRs and odds ratios (ORs with corresponding confidence intervals (CIs were calculated to assess the prognostic value of HIF-1α expression. The standard mean difference was used to analyze the continuous variable.  Results: Finally, nine studies comprising 486 patients were subjected to final analysis. Protein expression level of HIF-1α was found to be significantly related to overall survival (HR =3.0; 95% CI: 1.46–6.15, disease-free survival (HR =2.23; 95% CI: 1.26–3.92, pathologic grade (OR =21.33; 95% CI: 4.60–98.88, tumor stage (OR =10.29; 95% CI: 3.55–29.82, chemotherapy response (OR =9.68; 95% CI: 1.87–50.18, metastasis (OR =5.06; 95% CI: 2.87–8.92, and microvessel density (standard mean difference =2.83; 95% CI: 2.28–3.39.  Conclusion: This meta-analysis revealed that overexpression of HIF-1α is a predictive factor of poor outcomes for osteosarcoma. HIF-1α appeared to play an important role in prognostic evaluation and may be a potential target in antitumoral therapy. Keywords: HIF-1α, osteosarcoma, prognosis, meta-analysis

  10. Tai Ji Quan for the aging cancer survivor: Mitigating the accelerated development of disability, falls, and cardiovascular disease from cancer treatment

    Directory of Open Access Journals (Sweden)

    Kerri M. Winters-Stone

    2014-03-01

    Full Text Available Currently there are more than 13.7 million cancer survivors living in the U.S., and that figure is projected to increase by 31% in the next decade, adding another 4 million cancer survivors into the healthcare system. Cancer is largely a disease of aging, and the aging of the population will sharply raise the proportion of older cancer survivors, many of whom will be long-term survivors (5+ years post diagnosis. This review will address the potential utility of exercise to address three health problems that are of particular concern for the aging cancer survivor and the healthcare system, i.e., disability, falls, and cardiovascular disease, because the development of these age-related problems may be accelerated by cancer treatment. While there are many different modes of exercise that each produce specific adaptations, Tai Ji Quan may be a particularly suitable strategy to mitigate the development of age- and cancer-treatment-related problems. Based on studies in older adults without cancer, Tai Ji Quan produces musculoskeletal and cardiometabolic adaptations and is more easily performed by older adults due to its low energy cost and slower movement patterns. Since cancer survivors are mostly older, inactive, and often physically limited by the lingering side effects of treatment, they need to engage in safe, practical, and effective modes of exercise. The dearth of published controlled trials examining the efficacy of Tai Ji Quan to mitigate cancer-treatment-related musculoskeletal and cardiovascular side effects points to ample research opportunities to explore the application of this non-Western exercise modality to improve long-term outcomes for aging cancer survivors.

  11. Effect of YangZheng XiaoJi Extract, DME-25, on endothelial cells and their response to Avastin.

    OpenAIRE

    Owen, Sioned; Gao, Y.; Zhi, X.; Wei, C.; Wu, Y.; Jiang, Wen Guo

    2016-01-01

    ackground: Angiogenesis is a cellular process that has been identified as a key target for therapy in solid cancer. However, over the course of anti-angiogenic therapies, cancer cells acquire resistance to these therapies after an initial period of success. DME-25 is an extract from Yang Zheng Xiao Ji, a traditional Chinese medicine that has been reported to benefit patients with cancer by alleviating chemotherapy-associated symptoms and possibly inhibiting key cancer cell traits. This study ...

  12. 75 FR 62173 - In the Matter of the Review of the Designation of Jemaah Islamiya (JI and Other Aliases) as a...

    Science.gov (United States)

    2010-10-07

    ... DEPARTMENT OF STATE [Public Notice: 7196] In the Matter of the Review of the Designation of Jemaah Islamiya (JI and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of the Immigration and Nationality Act, as Amended Based upon a review of the Administrative Record assembled in this...

  13. Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid.

    Science.gov (United States)

    Xu, Gui-li; Li, Hong-liang; He, Jian-chang; Feng, En-fu; Shi, Pan-pan; Liu, Yue-qiong; Liu, Chang-xiao

    2013-08-26

    Qing Ye Dan is a well-known herbal drug that is widely used to treat viral hepatitis in the Yi and Hani minority regions in the Yunnan province of China. An LC-MS/MS method was developed to determine the levels of swertiamarin in rat plasma. Swertiamarin and naringin (internal standard, IS) were extracted from rat plasma using solid-phase extraction (SPE) to purify the samples. The pharmacokinetics of the following different administration methods of swertiamarin in rats were studied: oral administration of swertiamarin alone, a Qing Ye Dan tablet (QYDT) and co-administration of swertiamarin and oleanolic acid, with each method delivering approximately 20mg/kg of swertiamarin. Non-compartmental pharmacokinetic profiles were constructed by using the software DAS (version 2.1.1), and the pharmacokinetic parameters were compared using an unpaired Student's t-test. The results showed that the pharmacokinetic parameters Cmax, AUC0-∞, Vz/F and CLz/F were significantly different (P<0.05) among the three types of swertiamarin administration. The data indicate that oleanolic acid and the other ingredients present in QYDT could affect the pharmacokinetic behaviour of swertiamarin in rats. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  14. Toplumcu gerçekçilik ve Sabahattin Ali'nin hikâye kişileri

    OpenAIRE

    Hasdedeoğlu, Mehmet Onur

    2008-01-01

    Bu çalısmanın konusu, günümüzde devrini tamamlamıs olan toplumcu gerçekçilik akımının ilkeleri dorultusunda, Sabahattin Ali'nin hikâye kisilerini tanımaktır. Ulasılması hedeflenen amaç, edebiyatın çesitli türlerinde eserler vermis olmasına karsın daha çok hikâyeci kimligiyle öne çıkan Sabahattin Ali'nin, hikâyelerinde yarattıgı kahramanları inceleme yoluyla, temsilcisi oldugu toplumcu gerçekçilik akımı içerisindeki yerini belirlemektir. Çalısmanın çekirdegini olusturan ?Sabahattin Ali'nin Hik...

  15. The Influence of Romanticism on Mirzade-ye-eshgi’s Artistic Products

    Directory of Open Access Journals (Sweden)

    Fatemeh Moddaresi

    2012-10-01

    Full Text Available  Abstract Romanticism is a literarily movement which in last years of 18 the century , derived from England and changed to literally school in 19 century reaching most of the European countries, western Europe and even Russia. This school has deeply in flounced on different aspects of literature in different parts of the world. Romanticism school pierced into Iranian literature, when Iranian poets and writers got introduced with western literature. “ mirzade-ye-eshgi” is one of those poets who we can cleanly see the effects of romanticism school in his poems, since the value of this literarily products owes to romanticism school elements. Revolutionary, creativity, Retiring idealism flash backs to traditional literarily forms national emotions nostalgia creating atmospheres full of sadness and showing sympathy toward the poor, are ports of romanticism school in fluencies on his poems.   Â

  16. Competition between Chaotic and Nonchaotic Phases in a Quadratically Coupled Sachdev-Ye-Kitaev Model.

    Science.gov (United States)

    Chen, Xin; Fan, Ruihua; Chen, Yiming; Zhai, Hui; Zhang, Pengfei

    2017-11-17

    The Sachdev-Ye-Kitaev (SYK) model is a concrete solvable model to study non-Fermi liquid properties, holographic duality, and maximally chaotic behavior. In this work, we consider a generalization of the SYK model that contains two SYK models with a different number of Majorana modes coupled by quadratic terms. This model is also solvable, and the solution shows a zero-temperature quantum phase transition between two non-Fermi liquid chaotic phases. This phase transition is driven by tuning the ratio of two mode numbers, and a nonchaotic Fermi liquid sits at the critical point with an equal number of modes. At a finite temperature, the Fermi liquid phase expands to a finite regime. More intriguingly, a different non-Fermi liquid phase emerges at a finite temperature. We characterize the phase diagram in terms of the spectral function, the Lyapunov exponent, and the entropy. Our results illustrate a concrete example of the quantum phase transition and critical behavior between two non-Fermi liquid phases.

  17. Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo Plants

    Directory of Open Access Journals (Sweden)

    Yue-Hu Wang

    2014-01-01

    Full Text Available The ethnomedical uses of Piper (胡椒 Hú Jiāo plants as anticancer agents, in vitro cytotoxic activity of both extracts and compounds from Piper plants, and in vivo antitumor activity and mechanism of action of selected compounds are reviewed in the present paper. The genus Piper (Piperaceae contains approximately 2000 species, of which 10 species have been used in traditional medicines to treat cancer or cancer-like symptoms. Studies have shown that 35 extracts from 24 Piper species and 32 compounds from Piper plants possess cytotoxic activity. Amide alkaloids account for 53% of the major active principles. Among them, piplartine (piperlongumine shows the most promise, being toxic to dozens of cancer cell lines and having excellent in vivo activity. It is worthwhile to conduct further anticancer studies both in vitro and in vivo on Piper plants and their active principles.

  18. 5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16Ink4a expression in lung tissue

    Directory of Open Access Journals (Sweden)

    He ZH

    2017-10-01

    Full Text Available Zhi-Hui He,1 Yan Chen,2 Ping Chen,2 Sheng-Dong He,2 Hui-Hui Zeng,2 Ji-Ru Ye,2 Da Liu,2 Jun Cao3 1Intensive Care Unit, 2Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, 3Department of Respiratory Medicine, Hunan Provincial People’s Hospital, Changsha, China Background: There is a growing realization that COPD, or at least emphysema, involves several processes presenting in aging and cellular senescence. Endothelial progenitor cells (EPCs contribute to neovascularization and play an important role in the development of COPD. The gene for p16Ink4a is a major dominant senescence one. The aim of the present study was to observe changes in lung function, histomorphology of lung tissue, and expression of p16Ink4a in lung tissue and bone marrow-derived EPCs in emphysematous mice induced by cigarette-smoke extract (CSE, and further to search for a potential candidate agent protecting against emphysema induced by CSE. Materials and methods: An animal emphysema model was induced by intraperitoneal injection of CSE. 5-Aza-2'-deoxycytidine (5-Aza-CdR was administered to the emphysematous mice. Lung function and histomorphology of lung tissue were measured. The p16Ink4a protein and mRNA in EPCs and lung tissues were detected using Western blotting and quantitative reverse-transcription polymerase chain reaction, respectively. Results: CSE induced emphysema with increased p16Ink4a expression in lung tissue and bone marrow-derived EPCs. 5-Aza-CdR partly protected against emphysema, especially in the lung-morphology profile, and partly protest against the overexpression of p16Ink4a in EPCs and lung tissue induced by CSE. Conclusion: 5-Aza-CdR partly protected against emphysema in mice via suppressing p16Ink4a expression in EPCs and lung tissue. Keywords: 5-Aza-2'-deoxycytidine, cigarette smoke, emphysema, endothelial progenitor cells, p16Ink4a

  19. The coastline remote sensing survey for Zhao Shu Island in Xisha Islands based on WorldView-2

    Science.gov (United States)

    Li, Li; Zhong, Chang; Kong, Fanping

    2014-11-01

    Due to diastrophism, tide action and human activities, the coastline is always in flux. There are lots of coral islands in the south sea of China. Remote sensing survey for the coastline not only can reassert the necessity and importance of coral protection, but also can provide basic data and scientific basis for island ecologic protection, reasonable utilization of land resources. The study area named Zhao Shu Island lies in Jintong Islands of Xisha. It is a coral island which has people inhabited. Using WorldView-2 satellite remote sensing images as data sources we carry out three phases of coastline investigation and monitoring. The satellite data phases are 2002, 2010 and 2013. Firstly, affirm the bands valuable for color composition on the basis of spectral and correlation analysis. Then extract the coastline by a series of image process, such as image correction, fusion, waterline extraction and coastline revision. Finally determine the coastline types and length by artificial interpretation. The results show that the island length is gradually smaller, which means the island area is reducing. The beach bedrock coast in northern island was eroded seriously especially during the period between 2010 and 2013. In addition, the shoal head shape in the western island changed a lot.

  20. Pražský světící biskup? Jiří Ignác Pospíchal (1635–1699)

    Czech Academy of Sciences Publication Activity Database

    Pučalík, Marek

    2015-01-01

    Roč. 30, č. 1 (2015), s. 159-169 ISSN 0231-7494 R&D Projects: GA ČR(CZ) GA14-05167S Institutional support: RVO:67985963 Keywords : Jiří Ignác Pospíchal * the Knights of the Cross with the Red Star * Prague * Polná * bishop * archbishop Subject RIV: AB - History

  1. JEOTERMAL MERKEZİ ISITMA AÇISINDAN KONUT ÖZELLİKLERİ VE DENİZLİ'NİN JEOTERMAL ENERJİYE BAKIŞI

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    Halil KARAHAN

    1996-01-01

    Full Text Available Hava kirliliği sorununa etkili bir çözüm olarak yaklaşık on yıldır, Kızıldere Jotermal sahasından elde edilen jeotermal akışkanın Denizli'nin merkezi ısıtılmasında kullanımı sürekli gündemde bulunmasına rağmen bu güne kadar konut sayıları, konut alanları, ısınma türü, konut başına kömür tüketimi, ısı yalıtımı, mevcut binaların ne kadarının kaloriferli olduğu gibi projenin maliyetini doğrudan etkileyecek veriler ya keyfi olarak seçilmiş, ya da Denizli' ye göre yerleşim alanı ve nüfusu çok küçük olan yerler esas alınarak değerlendirmeler yapılmıştır. Yapılacak projenin istenilen amaca hizmet edebilmesi için Denizli' ye ait değerlerin elde edilmesi, fizibilite ve projelendirme aşamalarında bu değerlerin kullanılması gerekir. Bu amaçla Denizli şehir merkezinde, değişik gelir gruplarını ve konut özelliklerini temsil eden yaklaşık 15000 bağımsız birime (konut, işyeri ekte verilen anket formu dağıtılmış ve anket formları bilgisayar aracılığıyla değerlendirilmiş ve sonuçlar grafik olarak sunulmuştur.

  2. Efficacy of rehabilitation with Tai Ji Quan in an Italian cohort of patients with Fibromyalgia Syndrome.

    Science.gov (United States)

    Maddali Bongi, Susanna; Paoletti, Gianluca; Calà, Michael; Del Rosso, Angela; El Aoufy, Khadija; Mikhaylova, Svetlana

    2016-08-01

    Fibromyalgia Syndrome (FMS) is characterized by musculoskeletal pain, muscle tenderness leading to disability, impaired quality of life (QoL), fatigue and it is accompanied by sleep disorders and psychological distress. Mind body therapies (MBT), such as Tai Ji Quan (TJQ), use different techniques to facilitate the ability of the mind to influence disease characteristics and symptoms. Some studies showed that TJQ, in patients with rheumatic diseases, particularly FMS, improved QoL, disability and psychological distress. To evaluate the efficacy of TJQ on disability, QoL, fatigue, sleep and psychological distress in an Italian cohort of FMS patients. We enrolled 44 FMS patients: 22 patients (Experimental Group) participated to a course of Tai Ji Quan style of (2/week for 16 weeks); 22 patients (Control Group) participated to an educational course about FMS (2/week for 16 weeks). At baseline (T0) and at the end of treatment (T1), patients were assessed for disability [Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ)], Quality of Life [Short-Form 36 (SF36)], fatigue [Functional Assessment of Chronic Illness-Fatigue (FACIT-F)], pain [Widespread Pain Index (WPI)], tenderness [Tender Points (TP)], Sleep Quality [Pittsburgh Sleep Quality Index (PSQI)] and mood disorders [Hospital Anxiety and Depression Scale (HADS)]. At T1 versus T0, patients of the Experimental Group showed a significant improvement in FIQ, FACIT, SF36 (Summary Physical Index, Physical activity, physical role, bodily pain, general health, vitality, emotional role limitations), in WPI, TP, PSQI (total, sleep duration, and sleep disturbance) and HADS (total score and anxiety subscale), while Patients in the Control Group did not improve in any parameter. In FMS patients TJQ, if performed by an expert physiotherapist, should be regarded as an effective rehabilitation method. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Conversion of acid hydrolysate of oil palm empty fruit bunch to L-lactic acid by newly isolated Bacillus coagulans JI12.

    Science.gov (United States)

    Ye, Lidan; Hudari, Mohammad Sufian Bin; Zhou, Xingding; Zhang, Dongxu; Li, Zhi; Wu, Jin Chuan

    2013-06-01

    Cost-effective conversion of lignocellulose hydrolysate to optically pure lactic acid is commercially attractive but very challenging. Bacillus coagulans JI12 was isolated from natural environment and used to produce L-lactic acid (optical purity > 99.5 %) from lignocellulose sugars and acid hydrolysate of oil palm empty fruit bunch (EFB) at 50 °C and pH 6.0 without sterilization of the medium. In fed-batch fermentation with 85 g/L initial xylose and 55 g/L xylose added after 7.5 h, 137.5 g/L lactic acid was produced with a yield of 98 % and a productivity of 4.4 g/L h. In batch fermentation of a sugar mixture containing 8.5 % xylose, 1 % glucose, and 1 % L-arabinose, the lactic acid yield and productivity reached 98 % and 4.8 g/L h, respectively. When EFB hydrolysate was used, 59.2 g/L of lactic acid was produced within 9.5 h at a yield of 97 % and a productivity of 6.2 g/L h, which are the highest among those ever reported from lignocellulose hydrolysates. These results indicate that B. coagulans JI12 is a promising strain for industrial production of L-lactic acid from lignocellulose hydrolysate.

  4. Uso do res?duo da esta??o de tratamento de ?gua de Ji-Paran?/RO como material ciment?cio

    OpenAIRE

    Rocha, Maria Angelica Froes da

    2016-01-01

    O lodo ? um subproduto inevit?vel no tratamento da ?gua a ser fornecida a uma popula??o, sendo que a sua disposi??o final muitas vezes ? realizada de forma inadequada e n?o sustent?vel. A argamassa ? uma mistura de cimento, areia e ?gua. Este trabalho tem o objetivo de avaliar a substitui??o parcial do agregado mi?do pelo lodo produzido na esta??o de tratamento de ?gua de Ji-Paran? na produ??o de argamassa. A metodologia utilizada no presente estudo consistiu na coleta e secagem do lodo, cara...

  5. Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men).

    Science.gov (United States)

    Tang, Yingzhan; Ling, Junhong; Zhang, Peng; Zhang, Xiangrong; Zhang, Na; Wang, Wenli; Li, Jiayuan; Li, Ning

    2015-08-15

    Because of platelets as critical factor in the formation of pathogenic thrombi, anti-platelet activities have been selected as therapeutic target for various circulatory diseases. In order to find potential therapeutic agents, bioassay-directed separation of Bauhinia glauca Benth.subsp. pernervosa. (called Da Ye Guan Men as a traditional Chinese medicine) was performed to get 29 main components (compounds 1-29) from the bioactive part of this herbal. It was the first time to focus on the composition with anti-platelet aggregation activities for this traditional Chinese medicine. The constituents, characterized from the effective extract, were established on the basis of extensive spectral data analysis. Then their anti-platelet aggregation effects were evaluated systematically. On the basis of the chemical profile and biological assay, it was suggested that the flavonoid composition (5 and 18) should be responsible for the anti-platelet aggregation of the herbal because of their significant activities. The primary structure and activity relationship was also discussed briefly. Copyright © 2015. Published by Elsevier Ltd.

  6. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  7. The conservation treatment of a contemporary collaged sculpture by Jiří Kolář (1914-2002

    Directory of Open Access Journals (Sweden)

    Jessica Crann

    2010-11-01

    Full Text Available Une sculpture représentant une pomme réalisée par collage de l’artiste tchèque Jiří Kolář et datant de 1972, a été soumise à un traitement de conservation-restauration. La sculpture présentait des dommages structurels causés par des facteurs externes ainsi que des surfaces encrassées. Les interrogations déontologiques soulevées lors de la restauration d’une œuvre d’art contemporain ont représenté un aspect important de l’étude. Par conséquent, la majeure partie des recherches a été dévolue à  la compréhension du matériau et de la structure, celle des intentions de l’artiste,tout comme du concept et de la signification de l’œuvre. Ce travail a été étayé par une recherche scientifique ayant pour but d’évaluer l’efficacité du Triammonium citrate comme agent de nettoyage à base aqueuse, ainsi que par une analyse de la construction en trois dimensions de l’œuvre d’art.A collaged sculpture of an apple by the Czech artist Jiří Kolář, dated 1972 was presented for conservation. The sculpture suffered from structural damage caused by external factors and ingrained surface dirt. The ethical implications raised in conserving a contemporary artwork were an important aspect and subsequently an understanding of the materials and structure, the artist’s intentions, concept and meaning of the artwork formed a large part of the research. Combined with this was scientific research into the effectiveness of Tri-ammonium Citrate as an aqueous surface cleaning agent and analysing construction of 3-Dimensional artworks.

  8. Environmental hazard mapping using GIS and AHP - A case study of Dong Trieu District in Quang Ninh Province, Vietnam

    Science.gov (United States)

    Anh, N. K.; Phonekeo, V.; My, V. C.; Duong, N. D.; Dat, P. T.

    2014-02-01

    In recent years, Vietnamese economy has been growing up rapidly and caused serious environmental quality plunging, especially in industrial and mining areas. It brings an enormous threat to a socially sustainable development and the health of human beings. Environmental quality assessment and protection are complex and dynamic processes, since it involves spatial information from multi-sector, multi-region and multi-field sources and needs complicated data processing. Therefore, an effective environmental protection information system is needed, in which considerable factors hidden in the complex relationships will become clear and visible. In this paper, the authors present the methodology which was used to generate environmental hazard maps which are applied to the integration of Analytic Hierarchy Process (AHP) and Geographical Information system (GIS). We demonstrate the results that were obtained from the study area in Dong Trieu district. This research study has contributed an overall perspective of environmental quality and identified the devastated areas where the administration urgently needs to establish an appropriate policy to improve and protect the environment.

  9. Effect of “Jian-Pi-Zhi-Dong Decoction” on Gamma-Aminobutyric Acid in a Mouse Model of Tourette Syndrome

    Directory of Open Access Journals (Sweden)

    Wen Zhang

    2014-01-01

    Full Text Available The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD on Tourette syndrome (TS by investigating the expression of gamma-aminobutyric acid (GABA and its type A receptor (GABAAR in the striatum of a TS mice model. The model was induced by 3,3′-iminodipropionitrile (IDPN treatment; then mice were divided into 4 groups (n=22, each; control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.

  10. Memory and endurance in the migration to the Amazon: the case of Nova Londrina in Ji-Parana, state of Rondonia, Brazil

    OpenAIRE

    Lediane Fani Felzke; Dalva Felipe de Oliveira; Jania Maria de Paula

    2014-01-01

    The occupation of Rondônia, from the 1970s, occurred in a disorganized way, since it attracted an amount of migrants which was much bigger than the settling projects could sustain. The aim of this research was to analyze the circumstances in which the district of Nova Londrina was settled, utilizing for this reason a bibliographic survey, as well as the Oral History method. The arrival in Nova Londrina, Ji-Paraná, was highlighted by conflicts between the settlers and the settling company Cala...

  11. İzmir İlinde Bulunan Termal Sularda Gelişen Bazı Termofilik Mavi-Yeşil Alglerin (Siyanobakterilerin İzolasyonu ve Moleküler Tayini.

    Directory of Open Access Journals (Sweden)

    Kerem Yüksel

    2015-12-01

    Full Text Available İzmir ili ve çevresindeki termal tesislerden elde edilen mavi-yeşil algler (siyanobakteriler laboratuar ortamında izole edilip, moleküler yöntemlerle tür tayini çalışılmıştır. Zeytindalı kaplıcaları, Şifne Termal Otel ve Balçova Termal Otel olmak üzere 3 istasyondan elde edilen 4 mavi-yeşil alg (siyanobakteri türü, laboratuarda kültür ortamında saflaştırılarak izole edilmişlerdir. Daha sonra elde edilen hücrelerden, DNA izolasyonu sonucu elde edilen DNA’lar PCR’da çoğaltılmıştır. Siyanobakterilere özgü primerler kullanılarak 16S rRNA gen bölgeleri tekrar PCR’da çoğaltılarak elde edilen dizi analizi verileri bilgisayar programlarında yorumlanarak filogenetik bakımdan tür tayini yapılmaya çalışılmıştır. Dizi analizlerine göre yapılan tür tayini doğrultusunda, örneklerden üçünün Geitlerinema cinsi olduğu diğer 1 türün ise kültürü belirlenmemiş tür olduğu belirtilmiştir

  12. Tua Ji Peh: The Intricacies of Liminality in the Deification of Chinese non-Buddhist Supernatural Beings in Chinese-Malaysian Communities

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    Whitney Webb

    2012-05-01

    Full Text Available The pragmatic, responsive, and syncretic nature of popular Chinese religion is well known and is thought to result, in part, from the religion’s close connection to the fluxes of the social system in which its adherents live. These characteristics often result in considerable change when the social fabric is greatly disrupted, such as in the immigration of Chinese to new and unfamiliar places. This process of change is commonly seen among Chinese deities. Tua Peh大伯 and Ji Peh 二伯 (in Hokkien dialect “First Uncle” and “Second Uncle”, two ghostly deities of popular Chinese Malaysian religion, are understood to have an ambiguous status in the Chinese pantheon as they possess characteristics of both gods and ghosts. In China, these figures were simply part of the otherworldly bureaucracy of the hell realm with a very limited role and were worshipped infrequently. In the past 20 years, their worship has become extremely ubiquitous, with many shrines and temples proliferating. Now a variety of people come to them for wealth, for healings, and for protection. This coincides during a time in which the economic situation of Chinese Malaysians has become more difficult which parallels a significant rise in political tensions between Malays and non-Malays. This has caused a shift towards favorability in the deities’ reputation, the demographics of their worshippers, and the reasons patrons seek their assistance. Overall, the elevation of Tua Ji Peh seems to work towards lending legitimacy to those desperately seeking efficacious aid in a increasingly discriminatory and poltically unstable environment with harsher realities.

  13. Universality and Thouless energy in the supersymmetric Sachdev-Ye-Kitaev model

    Science.gov (United States)

    García-García, Antonio M.; Jia, Yiyang; Verbaarschot, Jacobus J. M.

    2018-05-01

    We investigate the supersymmetric Sachdev-Ye-Kitaev (SYK) model, N Majorana fermions with infinite range interactions in 0 +1 dimensions. We have found that, close to the ground state E ≈0 , discrete symmetries alter qualitatively the spectral properties with respect to the non-supersymmetric SYK model. The average spectral density at finite N , which we compute analytically and numerically, grows exponentially with N for E ≈0 . However the chiral condensate, which is normalized with respect the total number of eigenvalues, vanishes in the thermodynamic limit. Slightly above E ≈0 , the spectral density grows exponentially with the energy. Deep in the quantum regime, corresponding to the first O (N ) eigenvalues, the average spectral density is universal and well described by random matrix ensembles with chiral and superconducting discrete symmetries. The dynamics for E ≈0 is investigated by level fluctuations. Also in this case we find excellent agreement with the prediction of chiral and superconducting random matrix ensembles for eigenvalue separations smaller than the Thouless energy, which seems to scale linearly with N . Deviations beyond the Thouless energy, which describes how ergodicity is approached, are universally characterized by a quadratic growth of the number variance. In the time domain, we have found analytically that the spectral form factor g (t ), obtained from the connected two-level correlation function of the unfolded spectrum, decays as 1 /t2 for times shorter but comparable to the Thouless time with g (0 ) related to the coefficient of the quadratic growth of the number variance. Our results provide further support that quantum black holes are ergodic and therefore can be classified by random matrix theory.

  14. Environmental hazard mapping using GIS and AHP – A case study of Dong Trieu District in Quang Ninh Province, Vietnam

    International Nuclear Information System (INIS)

    Anh, N K; Duong, N D; Phonekeo, V; My, V C; Dat, P T

    2014-01-01

    In recent years, Vietnamese economy has been growing up rapidly and caused serious environmental quality plunging, especially in industrial and mining areas. It brings an enormous threat to a socially sustainable development and the health of human beings. Environmental quality assessment and protection are complex and dynamic processes, since it involves spatial information from multi-sector, multi-region and multi-field sources and needs complicated data processing. Therefore, an effective environmental protection information system is needed, in which considerable factors hidden in the complex relationships will become clear and visible. In this paper, the authors present the methodology which was used to generate environmental hazard maps which are applied to the integration of Analytic Hierarchy Process (AHP) and Geographical Information system (GIS). We demonstrate the results that were obtained from the study area in Dong Trieu district. This research study has contributed an overall perspective of environmental quality and identified the devastated areas where the administration urgently needs to establish an appropriate policy to improve and protect the environment

  15. Air quality assessment by contingent valuation in Ji'nan, China.

    Science.gov (United States)

    Wang, Yan; Zhang, Yi-Sheng

    2009-02-01

    Along with urbanization and environmental deterioration within China, many residents' desire for improved air quality has increased. To address this topic, this study focuses on the relationship between poor air quality and residents' willingness to pay for improved air quality in the city of Ji'nan. As a means of quantifying an individual's willingness to pay (WTP) for improved air quality, a contingent valuation method (CVM) was employed. A sample of 1500 residents was chosen, based on the stratified sampling method. The respondents' WTP was then elicited through a series of face-to-face interviews, conducted using a range of hypothetical, open-ended scenario questions. The results showed that 59.7% of respondents were able to express a positive WTP, and that the average WTP was 100 Chinese Yuan (CNY) per person, per year. In order to establish the relationship between endogenous variables and WTP, both a Probit model on the probability of a positive WTP, and a stepwise regression model were constructed. Most parameters in the econometric analysis demonstrated the expected results. It was found that annual household income, expenditure on the treatment of respiratory diseases and workers in the family significantly influenced WTP. The rates of positive WTP and the monetary amount were also larger for men than for women. Unlike developed countries, most respondents regard air quality improvement as a government responsibility in that more than 40% of respondents had no incentive to bear the costs of attempting to achieve better air quality, indicating a relatively low environmental consciousness.

  16. Letter regarding Zhao et al. entitled " DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia".

    Science.gov (United States)

    Deenen, Maarten J; Henricks, Linda M; Sonke, Gabe S; Schellens, Jan Hm; Meulendijks, Didier

    2017-06-01

    Zhao et al. investigated the association between germline genetic polymorphisms in DPYD, the gene encoding dihydropyrimidine dehydrogenase, and (1) the risk of developing pediatric acute lymphoblastic leukemia and (2) outcome of acute lymphoblastic leukemia following the treatment with 5-fluorouracil plus oxaliplatin (FOLFOX). The authors found that the common DPYD variant c.85T>C (rs1801265, DPYD*9A) was significantly associated with (1) risk of developing pediatric acute lymphoblastic leukemia, (2) complete response rate, (3) event-free survival, and (4) treatment-related toxicity. The authors conclude that patients carrying the c.85T>C C allele have an increased risk of developing acute lymphoblastic leukemia and have inferior outcome, and that DPYD c.85T>C can be used as a guide for individualized treatment and the decision to utilize 5-fluorouracil in acute lymphoblastic leukemia patients. In our view, the published article gives rise to multiple critical issues regarding the study's rationale and the methodology used, which strongly question the validity of the authors' conclusions.

  17. Der Österreich-Spiegel? – Jiří Grušas Essays Beneš als Österreicher und die Gebrauchsanweisung für Tschechien und Prag als Beispiele transkulturellen essayistischen Schreibens

    Czech Academy of Sciences Publication Activity Database

    Antošíková, Lucie; Budňák, J.; Schörkhuber, E.

    -, č. 8 (2014), s. 13-32. ISBN 978-3-7069-0726-2. ISSN 1802-6419 Institutional support: RVO:68378068 Keywords : Gruša, Jiří * Beneš, Edvard * German-language essays * construction of national narratives * transcultural writing Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Chemical display of pyrimidine bases flipped out by modification-dependent restriction endonucleases of MspJI and PvuRts1I families.

    Directory of Open Access Journals (Sweden)

    Evelina Zagorskaitė

    Full Text Available The epigenetic DNA modifications 5-methylcytosine (5mC and 5-hydroxymethylcytosine (5hmC in eukaryotes are recognized either in the context of double-stranded DNA (e.g., by the methyl-CpG binding domain of MeCP2, or in the flipped-out state (e.g., by the SRA domain of UHRF1. The SRA-like domains and the base-flipping mechanism for 5(hmC recognition are also shared by the recently discovered prokaryotic modification-dependent endonucleases of the MspJI and PvuRts1I families. Since the mechanism of modified cytosine recognition by many potential eukaryotic and prokaryotic 5(hmC "readers" is still unknown, a fast solution based method for the detection of extrahelical 5(hmC would be very useful. In the present study we tested base-flipping by MspJI- and PvuRts1I-like restriction enzymes using several solution-based methods, including fluorescence measurements of the cytosine analog pyrrolocytosine and chemical modification of extrahelical pyrimidines with chloroacetaldehyde and KMnO4. We find that only KMnO4 proved an efficient probe for the positive display of flipped out pyrimidines, albeit the method required either non-physiological pH (4.3 or a substitution of the target cytosine with thymine. Our results imply that DNA recognition mechanism of 5(hmC binding proteins should be tested using a combination of all available methods, as the lack of a positive signal in some assays does not exclude the base flipping mechanism.

  19. Trakyada Yeşilyurt Gazetesine Göre 1944 Yılında II. Dünya Savaşı ve Kırklareli

    Directory of Open Access Journals (Sweden)

    Türkan Vahibe DOĞRUÖZ

    2016-08-01

    Full Text Available Gazeteler günlük ya da haftalık olarak, özel bir konuda veya genel konularla ilgili güncel olayları ve gelişmeleri okuyucularına ileten yazılı belgelerdir. Bu belgeler aynı zamanda yayınladıkları dönemi günümüze taşıyan birincil kaynaklardır. İl özelinde çıkan yerel gazetelerde ilde yaşanan siyasi, ekonomik, sosyal ve kültürel gelişmelere ilişkin okuyuculara ve araştırmacılara bilgi sağlarlar. Ali Rıza Dursunkaya tarafından 31 Ağustos 1925 tarihinde yayın hayatına başlayan Trakya’da Yeşilyurt gazetesi de Kırklareli’nin ilk yerel gazetesi olma özelliğini taşımaktadır. Günümüze kadar yayım hayatına devam eden gazete Kırklareli’nde yaşanan siyasi, ekonomik, sosyal ve kültürel olayları bizlere ulaştırmaya devam etmektedir. Çalışmamızda Trakya’da Yeşilyurt gazetesinin II. Dünya Savaşı’nın son yıllarına rastlayan 1944 yılına ait 07 2. Kanun (Ocak 1944- 29 2. Kanun 1944 tarihleri arasında haftada iki gün Salı ve Cuma günleri yayımlanan 1313-1413 sayıları incelenecektir. Böylece Türkiye’nin II. Dünya Savaşı sırasında yaşadığı zor günler Kırklareli örneği ile anlatılmaya çalışılacaktır. Amacımız II. Dünya Savaşı’nın yaşandığı günlerde siyasi, ekonomik, sosyal ve kültürel açıdan Kırklareli’nde yaşananları o günün gazete haberlerini kronolojik bir sıra takip ederek mevcut durumu incelemektir. Trakya’da Yeşilyurt gazetesi ile ilgili olarak böyle bir çalışmanın daha önce yapılmamış olması göz önüne alındığında dönemle ilgili Kırklareli iline yeni bir bakış açısı getireceği düşünülmektedir. İkinci Dünya Savaşı’nın son yıllarına tekabül eden ve Türkiye’nin zor zamanlarına tanıklık etmiş savaş haberleri dışında eğitim, ekonomi, tarım kooperatif, kültür, sanat, sağlık, spor, haberleriyle halka ışık tutacaktır.

  20. The effect of Ga-mee-gwui-ryong-tang and Yuk-mee ji-hwang-tang Herbal-acupuncture on the growth of mice

    Directory of Open Access Journals (Sweden)

    Min-jung Kim

    2006-12-01

    Full Text Available Objectives : To investigate the effect of Ga-mee-Gwui-ryong-tang herbal acupuncture (GR-HA at GB39 and ST36 and the effect of Yuk-mee ji-hwang-tang herbal acupuncture (YM-HA at GB39 and KI10 on growth in mice. Methods : Mice were divided into 7 groups(n=10 ; saline-ST36, saline-GB39, saline-KI10, GR-HA-ST36 group treated with GR-HA at right ST36, GR-HA-GB39 group treated with GR-HA at right GB39, YM-HA-GB39 group treated with YM-HA at right GB39, YM-HA-KI10 group treated with YM-HA at right KI10. Saline-ST36 group, saline-GB39 group and saline-KI10 group were injected with saline at right ST36, GB39, KI10 respectively. Saline injection and HA were performed 3 times a week for 18 days. The length(total height, body length and tail length, weight and the protein efficiency ratio were measured as well as IGF-1 level in serum. Results : 1. GR-HA at GB39 and GR-HA at ST36 promoted growth in weight, tail length and total height but there was no statistical significance. 2. GR-HA at GB39 significantly promoted protein efficiency on the 14th day and GR-HA at ST36 on the 3rd day. 3. GR-HA at GB39 significantly increased serum IGF-1. GR-HA at ST36 increased IGF-1 slightly but with no statistical significance. 4. YM-HA at GB39 and YM-HA at KI10 promoted growth in weight, height, tail length and total height but there was no statistical relevance. 5. YM-HA at GB39 and YM-HA at KI10 significantly promoted protein efficiency on the 14th day. 6. YM-HA at GB39 and YM-HA at KI10 significantly increased serum IGF-1. Serum IGF-1 level of YM-HA-KI10 group was significantly higher than that of YM-HA-GB39 group. 7. Serum IGF-1 level of GR-HA-GB39 group was significantly higher than that of YM-HA-GB39 group. Conclusions : GR-HA and YM-HA both may promote growth. This study suggests that herbal acupuncture at GB39 is more effective with Gwui-ryong-tang than Yuk-mee ji-hwang-tang to promote growth. It also suggests that Yuk-mee ji-hwang-tang herbal acupuncture is more

  1. Papīra darbi ka domāšanas veicinātāji pirmsskolā

    OpenAIRE

    Jevdokimova, Jūlija

    2017-01-01

    Jūlija J. (2017.) “Papīra darbi kā domāšanas veicinātāji pirmsskolā”. Kvalifikācijas darbs. Rīga: Latvijas Universitātes Pedagoģijas, psiholoģijas un mākslas fakultāte, 90 lpp, 16 att., 4 tab., bibl. 18 nos., latviešu, angļu val. Darbs sastāv no ievada, 5 nodaļām, secinājumiem un 16 pielikumiem. Autors ir vairākus mēnešus izgājis praksi pirmsskolas pedagoga amatā. Darbā ir veikts pētījums par domāšanas attīstību rokdarbu nodarbībās, veicot papīra darbus Darba mērķis ir izzināt un atklāt bēr...

  2. Photoresponsive nanocapsulation of cobra neurotoxin and enhancement of its central analgesic effects under red light

    Directory of Open Access Journals (Sweden)

    Yang Q

    2017-05-01

    Full Text Available Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China Abstract: Cobra neurotoxin (CNT, a peptide isolated from snake venom of Naja naja atra, shows central analgesic effects in our previous research. In order to help CNT pass through blood–brain barrier (BBB and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice. The CNT nanocapsules had an average particle size of 229.55 nm, zeta potential of -53.00 mV, encapsulation efficiency of 84.81% and drug loading of 2.98%, when the pheophorbide content was 1% of lecithin weight. Pheophorbide was mainly distributed in outer layer of the CNT nanocapsules and increased the release of the CNT nanocapsules after 650 nm illumination. The central analgesic effects were improved after intraperitoneal injection of CNT at 25 and 50 µg·kg-1 under 650 nm irradiation for 30 min in the nasal cavity. Activation of pheophorbide by red light generated reactive oxygen species which opened the nanocapsules and BBB and helped the CNT enter the brain. This research provides a new drug delivery for treatment of central pain. Keywords: cobra neurotoxin, nanocapsules, photoresponsive, central analgesic effects, red light, drug delivery, photosensitizer

  3. Albino Farelerde Bisfenol A Tarafından Teşvik Edilen Genotoksisiteye Karşı Yeşil Kahvenin Koruyucu Rolünün Araştırılması

    Directory of Open Access Journals (Sweden)

    Burhan İŞTAR

    2016-09-01

    Full Text Available Özet. Bu çalışmada gıda ve içecek ambalajlama materyallerinde sıkça kullanılan kimyasal maddelerden biri olan Bisfenol A (BFA’nın Swiss albino farelerde muhtemel fizyolojik ve genotoksik etkileri ile bu etkilere karşı yeşil kahvenin koruyucu rolü araştırılmıştır. Fizyolojik etkiler; canlı ağırlık ve karaciğer-böbrek organ ağırlıklarının ölçümü ile genotoksik etkiler ise; eritrosit ve yanak mukoza epitelyum hücrelerindeki mikronukleus (MN sıklığının, kemik iliği hücrelerinde ise kromozomal hasar oluşumunun tespitiyle değerlendirilmiştir. Fareler her grupta altı (6 hayvan olacak şekilde toplam altı (6 gruba ayrılmış, kontrol grubundaki fareler çeşme suyu, uygulama grubundaki fareler ise yeşil kahvenin 100 mg/kg c.a ve 400 mg/kg c.a dozlarıyla ve BFA’nın 50 mg/kg c.a dozuyla beslenmişlerdir. Sonuçta BFA uygulaması canlı ağırlıklarda ve organ ağırlıklarında istatistiksel açıdan önemli bir azalmaya neden olurken, MN ve kromozomal anormallik sıklığında ise önemli bir artışa neden olmuştur. Yeşil kahve uygulaması ise BFA’nın söz konusu olumsuz etkilerini iyileştirerek, tüm parametrelerde doza bağlı bir iyileşme göstermiştir. BFA’nın belli bir doz eşiğinden sonra toksisiteye sebep olduğu, yeşil kahvenin ise bu toksisiteyi azaltmada etkili bir antioksidant ürün olduğu anlaşılmıştır.Anahtar Kelimeler: Bisfenol A, Fizyoloji, Genotoksisite, Kromozomal Anormallikler, Mikronukleus, Yeşil Kahve Abstract. This study researches into the potential physiologic and genotoxic effects of Bisphenol A, which is one of the most frequent chemical substance used in food and beverage packaging materials, on Swiss Albino mice and the protective role of green coffee against these effects. The study analyzes the physiologic effects by measuring the live weight, liver and kidney weight, whilst determining the genotoxic effects by frequency of micronucles (MN on

  4. Sequence stratigraphy and environmental background of the late Pleistocene and Holocene occupation in the Southeast Primor'ye (the Russian Far East)

    Science.gov (United States)

    Chlachula, Jiri; Krupyanko, Alexander A.

    2016-06-01

    The paper presents the results of Quaternary palaeoecology and geoarchaeology studies in the Zerkal'naya Basin, with new insights about sequenced natural shifts during the prehistoric occupation of this marginally explored NE Asian maritime territory. The Basin is part of the continental drainage system and the main physiographic and biotic corridor for peopling of the transitive coastal interior SE Primor'ye Region. The Final Pleistocene and Holocene environmental (biotic and abiotic) proxy records from the Upper/Final Palaeolithic to early historical sites document a dynamic climate change with vegetation cover transformations within riverine and mountain valley ecosystems of the Russian Far East. Most of the archaeological sites located on the low terraces and bedrock promontories along the main river channel and its tributary streams suggest traditional hunter gathered lifestyles based on seasonal salmon-fishing supplemented by pastoral economy. Tundra-forests with larch trees, dwarf birch thickets and polypod ferns from the basal stratigraphic units of the late Last Glacial occupation sites associated with the Upper Palaeolithic micro-blade and bifacial stone tool traditions (14C-dated to 19,000-12,000 cal yrs BP) indicate rather pronounced conditions and much lower MAT comparing today. Following a final Pleistocene cooling event, a major climate warming marked the onset of Holocene accompanied by a regional humidity increase promoting the formation of a mixed broadleaved-coniferous oak-dominant taiga, and culminating in the mid-Holocene Climatic Optimum. The appearance of mosaic parklands ca. 5,000-4,000 cal yrs BP. may be partly attributed to the expansion of the Far Eastern Neolithic cultures practicing forest clearance for pastures and dwellings. A progressing landscape opening indicated by the spread of light-demanding thickets and birch-dominated riverine biotopes with Artemisia suggests a further vegetation cover transformation during the late Neolithic

  5. Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi.

    Science.gov (United States)

    Huang, Rong; Jiang, Bo-Guang; Li, Xiao-Nian; Wang, Ya-Ting; Liu, Si-Si; Zheng, Kai-Xuan; He, Jian; Wu, Shao-Hua

    2018-02-07

    Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising α-glycosidase inhibitory activity with IC 50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC 50 = 1.22 mM).

  6. Reconstruction of eroded monogenic Strombolian cones of Miocene age: A case study on character of volcanic activity of the Jičín Volcanic Field (NE Bohemia) and subsequent erosional rates estimation

    Czech Academy of Sciences Publication Activity Database

    Rapprich, V.; Cajz, Vladimír; Košťák, M.; Pécskay, Z.; Řídkošil, T.; Raška, P.; Radoň, M.

    2007-01-01

    Roč. 52, 3-4 (2007), s. 169-180 ISSN 0449-2560 R&D Projects: GA AV ČR IAA300130612 Institutional research plan: CEZ:AV0Z30130516 Keywords : cinder cone * Strombolian eruption * volcanic facies * erosion rate * Jičín Volcanic Field * Bohemian Paradise GeoPark Subject RIV: DB - Geology ; Mineralogy

  7. Research into the functional components and antioxidant activities of North China rice wine (Ji Mo Lao Jiu).

    Science.gov (United States)

    He, Shuai; Mao, Xiangzhao; Liu, Pei; Lin, Hong; Du, Zuyuan; Lv, Ning; Han, Jichen; Qiu, Cuifang

    2013-07-01

    Over the last decade, considerable experimental evidence has supported the view that grape wine and South China rice wine are rich in diverse nutrients and have powerful antioxidant activity. However, little research has been carried out for North China rice wine, of which Ji Mo Lao Jiu (JMLJ) is the outstanding representative. In this study, the functional components and antioxidant activity of JMLJ were investigated. Twenty-eight free amino acids were found in JMLJ, much more than that previously reported in other Chinese rice wines (16-21). Functional oligosaccharides (5290.222 mg/L), total phenols (722.431 ± 10.970 mg/L), and mineral elements (9) were rich in JMLJ. When compared with synthetic antioxidants, such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), JMLJ showed effective 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging and reducing capacity. The results of this study lay the foundation for promoting the utilization of JMLJ and the development of North China rice wine in the food industry.

  8. Assessment of injection safety in Ha Dong General Hospital, Hanoi, in 2012 [version 4; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Phan Van Tuong

    2017-11-01

    Full Text Available Background: Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH collaborated with the Vietnam Nurses Association to launch the “Safe injection” program throughout the country, including Hanoi. Methods: This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results: The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who were younger age group (OR=3.1; p<0.05 and fewer number of years working as a nurse (OR=2.8; p<0.05. Conclusions: While nurses have high level of knowledge about safe injections but a small proportion actually practiced. Experience may not always guarantee safe practices.  Injection safety training should be regularly imparted upon all categories of nurses.

  9. Assessment of injection safety in Ha Dong General Hospital, Hanoi, in 2012 [version 3; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Phan Van Tuong

    2017-09-01

    Full Text Available Background: Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH collaborated with the Vietnam Nurses Association to launch the “Safe injection” program throughout the country, including Hanoi. Methods: This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results: The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who are younger age group (OR=3.1; p<0.05 and lower amount of working years (OR=2.8; p<0.05. Conclusions: Despite the high level of knowledge about safety injection, a low proportion of nurses performed correct safety injection practice. Moreover, the results demonstrated that experience might not always guarantee better practice. The findings raise the need for further training about this issue, especially among older nurses.

  10. Dynamic Changes Analysis and Hotspots Detection of Land Use in the Central Core Functional Area of Jing-Jin-Ji from 2000 to 2015 Based on Remote Sensing Data

    Directory of Open Access Journals (Sweden)

    Yafei Li

    2017-01-01

    Full Text Available The article uses GIS spatial analysis and grid technologies to study the dynamic changes, hotspot regions, and driving forces in land use of the central core functional area of Jing-Jin-Ji. The research results are as follows: from 2000 to 2015, the main types of land use in the central core functional area of Jing-Jin-Ji are cultivated land, woodland, and built-up land. In the period of 2005–2010, the transfer between built-up land and cultivated land was frequent. The dynamic degree of single land use in unused land was highest. It also finds out that the dynamic degree of the integrated land use from 2005 to 2010 was higher. The center of gravity transfer of the dynamic degree of integrated land use was concentrated in research area. As for the hotspots, their number and scope are increasing, and the positions located in the edge of original main urban area and developed transportation network. The main characteristics of land use dynamic change in the study area are the rapid decrease of cultivated land area and rapid growth of built-up land. The spatial agglomeration of economic factors caused by human activities has an important influence on the spatial and temporal dynamic changes of land use.

  11. Association between grip strength and hand and knee radiographic osteoarthritis in Korean adults: Data from the Dong-gu study.

    Directory of Open Access Journals (Sweden)

    Lihui Wen

    Full Text Available We assessed whether grip strength was related to various types of radiographic damage in Korean adults with osteoarthritis (OA.Data from 2,251 subjects enrolled in the Dong-gu study, who had no hand joint pain, were analyzed to investigate the relationship between grip strength and OA. Hand grip strength was measured using a hand-held dynamometer, and radiographs of the hand and knee were scored according to a semi-quantitative grading system. Multiple linear regressions were used to explore associations between grip strength and radiographic features of OA.Grip strength in men and women was negatively related to hand (both p < 0.001 and knee (men, p < 0.001; women, p = 0.010 OA after adjusting for confounders. Hand (men, p < 0.001; women, p = 0.001 and knee (both p < 0.001 joint space narrowing (JSN showed the strongest associations with low grip strength, regardless of gender. Moreover, the severity of hand osteophytes in women (p = 0.001, and subchondral cysts (men, p < 0.001 was correlated with low grip strength in both genders.Among subjects without hand joint pain, low grip strength was associated significantly with hand and knee radiographic OA, regardless of gender. Among all types of OA radiographic damage, low grip strength showed the strongest association with JSN.

  12. Augsnes ķīmisko īpašību raksturojums bioloģiski vērtīgajos un daļēji dabiskajos zālājos Vaives pagastā

    OpenAIRE

    Elksnītis, Daniels

    2016-01-01

    Bioloģiski vērtīgos un daļēji dabiskos zālājus būtiski ietekmē augsnes īpašības. No augsnes īpašībām ir atkarīga šo zālāju kvalitāte, apsaimniekošanas veids un līdz ar to arī to sniegtie ekosistēmu pakalpojumi. Bioloģiski vērtīgo un daļēji dabisko zālāju nozīme arvien pieaug, turklāt jau pagājušā gadsimta otrajā pusē sākās strauja to platību samazināšanās gan Latvijā, gan Eiropā kopumā. Tāpēc ir ļoti būtiski noskaidrot bioloģiski vērtīgo zālāju augšņu īpašību ietekmējošos faktorus gan lokālā,...

  13. The determinants of long-term care utilization and equity of access to care among older adults in Dong-Ku of Incheon Metropolitan city, South Korea.

    Science.gov (United States)

    Park, J M

    2005-01-01

    Under the current health care system, around three percent of the elderly remain uninsured. Based on the 2003 Dong-Ku Health Status Survey and the Aday and Andersen Access Framework, the present study examined the social and behavioral determinants of long-term care utilization and the extent to which equity in the use of long-term care services for the elderly has been achieved. The results indicate that universal health insurance system has not yielded a fully equitable distribution of services. Type of coverage and resource availability do not remain predictors of long-term care utilization. The data suggest that a universal health insurance system exists in South Korea with significant access problems for the population without insurance. Access differences also arise from obstacles in expanding the scope and level of plan benefits due to financial disparity among insurers. Health policy reforms must continue to concentrate on extending insurance coverage to the uninsured and establishing long-term insurance system for the elderly.

  14. Examination of Story Books Produced Towards Preschool Children Regarding Elements of Violence and Horror Okul Öncesi Çocuklarına Yönelik Yayınlanan Hikâye Kitaplarının Şiddet ve Korku Öğeleri Açısından İncelenmesi

    Directory of Open Access Journals (Sweden)

    H. Elif Dağlıoğlu

    2009-09-01

    Full Text Available Story books are used as an indispensable tool for the education of children. Therefore, the high-quality story books that are prepared taking the age and development characteristics, needs and interests of the children into account gain even more importance. In this study, the violence and horror elements in the text and illustration parts of a total of 174 story books published in Turkey between 1995 and 2005 by 9 publishing houses, 52 of them being translations and 122 written by Turkish authors, are examined through an evaluation form created by researchers. In general, an average of 8 percent of violence and 11 percent of horror elements were found in the texts and illustrations of the story books. These elements were found mostly in translated books and books that are published under the category of world classics. Hikâye kitapları çocukların eğitiminde vazgeçilmez bir araç olarak kullanılmaktadır. Bunun için çocukların yaşları, gelişim özellikleri, ilgi ve ihtiyaçları dikkate alınarak hazırlanmış nitelikli hikâye kitapları büyük önem kazanmaktadır. Bu araştırmada Türkiye’de 1995-2005 yılları arasında 9 yayınevi tarafından basılmış 52’si çeviri, 122’si yerli olmak üzere toplam 174 hikâye kitabının metin ve resim kısımlarında bulunan şiddet ve korku öğeleri araştırmacılar tarafından oluşturulan bir değerlendirme formu ile incelenmiştir. Genel olarak hikâye kitaplarının metin ve resimlerinde ortalama % 8 şiddet, % 11 korku öğesi olduğu bulunmuştur. Söz konusu öğeler daha çok çeviri ve dünya klasikleri grubundaki kitaplarda tespit edilmiştir.

  15. Early age hydration of calcium sulfoaluminate (synthetic ye'elimite, ) in the presence of gypsum and varying amounts of calcium hydroxide

    KAUST Repository

    Hargis, Craig W.; Kirchheim, Ana Paula; Monteiro, Paulo J.M.; Gartner, Ellis M.

    2013-01-01

    Suspensions of synthetic ye'elimite (C4A3S̄) in a saturated gypsum (CS̄H2) and calcium hydroxide (CH) solution were examined in-situ in a wet cell by soft X-ray transmission microscopy and ex-situ by scanning electron microscopy. The most voluminous hydration product observed was ettringite. Ettringite commonly displayed acicular, filiform, reticulated, and stellate crystal habits. Additionally, pastes with C 4A3S̄, 15% CS̄H2, and varying amounts of CH were prepared and examined with X-ray diffraction (XRD) and isothermal calorimetry. The XRD experiments showed that increasing CH content caused more solid solution (SO4 2 -/OH-) AFm phases to form at early ages (< 1 d) and more monosulfate to form at later ages (> 1 d). Calorimetry indicated that the increased production of solid solution AFm was accompanied with an increase in the initial (< 30 min) rate of heat evolution, and increasing CH generally reduced the time till the second maximum rate of heat evolution due to the formation of ettringite and monosulfate. © 2013 Elsevier Ltd.

  16. Early age hydration of calcium sulfoaluminate (synthetic ye'elimite, ) in the presence of gypsum and varying amounts of calcium hydroxide

    KAUST Repository

    Hargis, Craig W.

    2013-06-01

    Suspensions of synthetic ye\\'elimite (C4A3S̄) in a saturated gypsum (CS̄H2) and calcium hydroxide (CH) solution were examined in-situ in a wet cell by soft X-ray transmission microscopy and ex-situ by scanning electron microscopy. The most voluminous hydration product observed was ettringite. Ettringite commonly displayed acicular, filiform, reticulated, and stellate crystal habits. Additionally, pastes with C 4A3S̄, 15% CS̄H2, and varying amounts of CH were prepared and examined with X-ray diffraction (XRD) and isothermal calorimetry. The XRD experiments showed that increasing CH content caused more solid solution (SO4 2 -/OH-) AFm phases to form at early ages (< 1 d) and more monosulfate to form at later ages (> 1 d). Calorimetry indicated that the increased production of solid solution AFm was accompanied with an increase in the initial (< 30 min) rate of heat evolution, and increasing CH generally reduced the time till the second maximum rate of heat evolution due to the formation of ettringite and monosulfate. © 2013 Elsevier Ltd.

  17. Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis

    Directory of Open Access Journals (Sweden)

    Ye CY

    2016-10-01

    Full Text Available Chenyang Ye,1,* Ji Wang,2,* Shu Zheng,1 Ying Chai3 1Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, 2Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: We report a rare case of advanced lung cancer with epidermal growth factor receptor and anaplastic lymphoma kinase co-alterations and brain metastasis, in which icotinib treatment was effective for both the primary lung tumor and the brain metastasis. The patient achieved important clinical remission with a progression-free survival for two years. Our treatment strategy appears to be a promising therapeutic approach for this subgroup of patients. Keywords: lung cancer, brain metastasis, EGFR, ALK, icotinib

  18. Henequén'ın Dönüşü, Bir Yeşil Lif İle Yucatan'da Karmaşık Bir Tarih

    OpenAIRE

    ANAYA, Yosi

    2014-01-01

    Meksika Mayaları ve Orta Amerika'nın önde gelen liflerinden birisi, sisal olarak bilinen Henequéndir. Sömürgecilik döneminin üretim merkezlerinden birisi olan Yucatan'ınadını alan Henequén, yüzyıllarca Yucatan Yarımadasının “Yeşil Altın”ı olarak bilindi. Yucatek ekonomisi, 20. yüzyıl boyunca ihtiyaç duyulan her türlü ip, halı,çuval ve kaba kumaşları sağlayan henequén tarlaları etrafında gelişti, yerleşti ve serpildi. 20. yüzyılda henequén lifi, daha ucuz fiyatlarla Madagaskar ve Ken...

  19. Research into the functional components and antioxidant activities of North China rice wine (Ji Mo Lao Jiu)

    Science.gov (United States)

    He, Shuai; Mao, Xiangzhao; Liu, Pei; Lin, Hong; Du, Zuyuan; Lv, Ning; Han, Jichen; Qiu, Cuifang

    2013-01-01

    Over the last decade, considerable experimental evidence has supported the view that grape wine and South China rice wine are rich in diverse nutrients and have powerful antioxidant activity. However, little research has been carried out for North China rice wine, of which Ji Mo Lao Jiu (JMLJ) is the outstanding representative. In this study, the functional components and antioxidant activity of JMLJ were investigated. Twenty-eight free amino acids were found in JMLJ, much more than that previously reported in other Chinese rice wines (16–21). Functional oligosaccharides (5290.222 mg/L), total phenols (722.431 ± 10.970 mg/L), and mineral elements (9) were rich in JMLJ. When compared with synthetic antioxidants, such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), JMLJ showed effective 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging and reducing capacity. The results of this study lay the foundation for promoting the utilization of JMLJ and the development of North China rice wine in the food industry. PMID:24804035

  20. Memory and endurance in the migration to the Amazon: the case of Nova Londrina in Ji-Parana, state of Rondonia, Brazil

    Directory of Open Access Journals (Sweden)

    Lediane Fani Felzke

    2014-12-01

    Full Text Available The occupation of Rondônia, from the 1970s, occurred in a disorganized way, since it attracted an amount of migrants which was much bigger than the settling projects could sustain. The aim of this research was to analyze the circumstances in which the district of Nova Londrina was settled, utilizing for this reason a bibliographic survey, as well as the Oral History method. The arrival in Nova Londrina, Ji-Paraná, was highlighted by conflicts between the settlers and the settling company Calama S/A. In spite of the company’s violence, the colonists resisted until there was an intervention from INCRA, through a land regularization program. In this context, the Urban Center for Rural Support (NUAR was implanted, intending to support the agricultural workers

  1. [Application of Multiple Genetic Markers in a Case of Determination of Half Sibling].

    Science.gov (United States)

    Yang, Xue; Shi, Mei-sen; Yuan, Li; Lu, Di

    2016-02-01

    A case of half sibling was determined with multiple genetic markers, which could be potentially applied for determination of half sibling relationship from same father. Half sibling relationship was detected by 39 autosomal STR genetic markers, 23 Y-chromosomal STR genetic markers and 12 X -chromosomal STR genetic markers among ZHAO -1, ZHAO -2, ZHAO -3, ZHAO -4, and ZHAO-5. According to autosomal STR, Y-STR and X-STR genotyping results, it was determined that ZHAO-4 (alleged half sibling) was unrelated with ZHAO-1 and ZHAO-2; however, ZHAO-3 (alleged half sibling), ZHAO-5 (alleged half sibling) shared same genetic profile with ZHAO-1, and ZHAO-2 from same father. It is reliable to use multiple genetic markers and family gene reconstruction to determine half sibling relationship from same father, but it is difficult to determination by calculating half sibling index with ITO and discriminant functions.

  2. Qi-Dong-Huo-Xue-Yin Inhibits Inflammation in Acute Lung Injury in Mice via Toll-Like Receptor 4/Caveolin-1 Signaling

    Directory of Open Access Journals (Sweden)

    Li-Ying Xu

    2018-01-01

    Full Text Available Acute lung injury (ALI is a critical illness with no current effective treatment. Caveolin-1 indirectly activates inflammation-associated signaling pathways by inhibiting endothelial nitric oxide synthase (eNOS. This induces an imbalance between pro- and anti-inflammatory cytokine levels, which are involved in the pathogenesis of ALI. The compound Chinese prescription Qi-Dong-Huo-Xue-Yin (QDHXY is efficacious for ALI treatment via an anti-inflammatory effect; however, the exact underlying mechanism is unknown. Therefore, we explored the protective effect of QDHXY against lipopolysaccharide- (LPS- induced ALI in mice. Histopathological changes in mouse lung tissues were studied. Furthermore, alterations in the serum levels of pro- and anti-inflammatory cytokines were investigated. The levels of tumor necrosis factor- (TNF-α, interleukin- (IL- 6, IL-1β, and interferon-γ-induced protein 10 in bronchoalveolar lavage fluid were measured. Additionally, the expression levels of myeloid differentiation factor 88 (MyD88, caveolin-1, and eNOS were assessed. QDHXY significantly reduced lung infiltration with inflammatory cells and the production of serum pro- and anti-inflammatory cytokines and inhibited the expression of TNF-α, IL-1β, caveolin-1, and MyD88 but not eNOS. These indicate that QDHXY significantly improved the balance between pro- and anti-inflammatory cytokine levels, possibly by inhibiting the caveolin-1 signaling pathway. Therefore, QDHXY may be a potential treatment for ALI.

  3. Space-time PM2.5 mapping in the severe haze region of Jing-Jin-Ji (China) using a synthetic approach.

    Science.gov (United States)

    He, Junyu; Christakos, George

    2018-05-07

    Long- and short-term exposure to PM 2.5 is of great concern in China due to its adverse population health effects. Characteristic of the severity of the situation in China is that in the Jing-Jin-Ji region considered in this work a total of 2725 excess deaths have been attributed to short-term PM 2.5 exposure during the period January 10-31, 2013. Technically, the processing of large space-time PM 2.5 datasets and the mapping of the space-time distribution of PM 2.5 concentrations often constitute high-cost projects. To address this situation, we propose a synthetic modeling framework based on the integration of (a) the Bayesian maximum entropy method that assimilates auxiliary information from land-use regression and artificial neural network (ANN) model outputs based on PM 2.5 monitoring, satellite remote sensing data, land use and geographical records, with (b) a space-time projection technique that transforms the PM 2.5 concentration values from the original spatiotemporal domain onto a spatial domain that moves along the direction of the PM 2.5 velocity spread. An interesting methodological feature of the synthetic approach is that its components (methods or models) are complementary, i.e., one component can compensate for the occasional limitations of another component. Insight is gained in terms of a PM 2.5 case study covering the severe haze Jing-Jin-Ji region during October 1-31, 2015. The proposed synthetic approach explicitly accounted for physical space-time dependencies of the PM 2.5 distribution. Moreover, the assimilation of auxiliary information and the dimensionality reduction achieved by the synthetic approach produced rather impressive results: It generated PM 2.5 concentration maps with low estimation uncertainty (even at counties and villages far away from the monitoring stations, whereas during the haze periods the uncertainty reduction was over 50% compared to standard PM 2.5 mapping techniques); and it also proved to be computationally very

  4. Function of AURKA protein kinase in the formation of vasculogenic mimicry in triple-negative breast cancer stem cells

    Directory of Open Access Journals (Sweden)

    Liu Y

    2016-06-01

    Full Text Available Ying Liu,1,2,* Baocun Sun,1–3,* Tieju Liu,1,2,* Xiulan Zhao,1,2 Xudong Wang,3 Yanlei Li,1,2 Jie Meng,2 Qiang Gu,1,2 Fang Liu,1,2 Xueyi Dong,1,2 Peimei Liu,2 Ran Sun,2 Nan Zhao1 1Department of Pathology, General Hospital of Tianjin Medical University, 2Department of Pathology, Tianjin Medical University, 3Department of Pathology, Cancer Hospital of Tianjin Medical University, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: Tumor cell vasculogenic mimicry (VM, a newly defined pattern of tumor blood supply, signifies the functional plasticity of aggressive cancer cells forming vascular networks. VM and cancer stem cells (CSCs have been shown to be associated with tumor growth, local invasion, and distant metastasis. In our previous study, CSCs in triple-negative breast cancer were potential to participate in VM formation. In this study, breast CSCs were isolated from the triple-negative breast cancer cell line MDA-MB-231 by using mammosphere culture. Western blotting and reverse transcription polymerase chain reaction showed that mammosphere cells displayed an increased expression of AURKA protein kinase and stem cell marker c-myc and sox2. The VM formation by mammosphere cells was inhibited by AURKA knockdown or the addition of AURKA inhibitor MLN8237. In the meantime, MLN8237 induced the increased E-cadherin and decreased c-myc, sox2, and β-catenin expressions. The function of AURKA in VM formation was further confirmed using a xenograft-murine model. The results suggested that AURKA protein kinase is involved in VM formation of CSCs and may become a new treatment target in suppressing VM and metastasis of breast cancer. Keywords: AURKA, cancer stem cells, vasculogenic mimicry, breast cancer

  5. Response to "Comment on `Solitonic and chaotic behaviors for the nonlinear dust-acoustic waves in a magnetized dusty plasma'" [Phys. Plasmas 24, 094701 (2017)

    Science.gov (United States)

    Zhen, Hui-Ling; Tian, Bo; Xie, Xi-Yang; Wu, Xiao-Yu; Wen, Xiao-Yong

    2018-02-01

    On our previous construction [H. L. Zhen et al., Phys. Plasmas 23, 052301 (2016)] of the soliton solutions of a model describing the dynamics of the dust particles in a weakly ionized, collisional dusty plasma comprised of the negatively charged cold dust particles, hot ions, hot electrons, and stationary neutrals in the presence of an external static magnetic field, Ali et al. [Phys. Plasmas 24, 094701 (2017)] have commented that there exists a different form of Eq. (4) from that shown in Zhen et al. [Phys. Plasmas 23, 052301 (2016)] and that certain interesting phenomena with the dust neutral collision frequency ν0>0 are ignored in Zhen et al. [Phys. Plasmas 23, 052301 (2016)]. In this Reply, according to the transformation given by the Ali et al. [Phys. Plasmas 24, 094701 (2017)] comment, we present some one-, two-, and N-soliton solutions which have not been obtained in the Ali et al. [Phys. Plasmas 24, 094701 (2017)] comment. We point out that our previous solutions in Zhen et al. [Phys. Plasmas 23, 052301 (2016)] are still valid because of the similarity between the two dispersion relations of previous solutions in Zhen et al. [Phys. Plasmas 23, 052301 (2016)] and the solutions presented in this Reply. Based on our soliton solutions in this Reply, it is found that the soliton amplitude is inversely related to Zd and B0, but positively related to md and α, where α refers to the coefficient of the nonlinear term, Zd and md are the charge number and mass of a dust particle, respectively, B0 represents the strength of the external static magnetic field. We also find that the two solitons are always in parallel during the propagation.

  6. Memória e resistência na migraçao para a Amazônia : O caso de Nova Londrina em Ji-Paraná, estado de Rondônia, Brasil

    OpenAIRE

    Felzke, Lediane Fani; Oliveira, Dalva Felipe de; Paula, Jania Maria de

    2014-01-01

    The occupation of Rondônia, from the 1970s, occurred in a disorganized way, since it attracted an amount of migrants which was much bigger than the settling projects could sustain. The aim of this research was to analyze the circumstances in which the district of Nova Londrina was settled, utilizing for this reason a bibliographic survey, as well as the Oral History method. The arrival in Nova Londrina, Ji-Paraná, was highlighted by conflicts between the settlers and the settling company Cala...

  7. Dong Quai

    Science.gov (United States)

    ... who had a stroke. Allergies. Anemia. Constipation. Early orgasm in men (premature ejaculation). High blood pressure. Joint ... 3 months. APPLIED TO THE SKIN: For early orgasm in men (premature ejaculation): A specific cream containing ...

  8. Efficient delivery of Notch1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposome

    Directory of Open Access Journals (Sweden)

    Zhao Y

    2016-10-01

    Full Text Available Yun-Chun Zhao,1 Li Zhang,2 Shi-Sen Feng,3 Lu Hong,3 Hai-Li Zheng,3 Li-Li Chen,4 Xiao-Ling Zheng,1 Yi-Qing Ye,1 Meng-Dan Zhao,1 Wen-Xi Wang,3 Cai-Hong Zheng1 1Pharmacy Department, Women’s Hospital, 2Pharmacy Department, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 3Department of Pharmaceutic Preparation, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 4Department of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Abstract: A novel cationic cholesterol derivative-based small interfering RNA (siRNA interference strategy was suggested to inhibit Notch1 activation in SKOV3 cells for the gene therapy of ovarian cancer. The cationic cholesterol derivative, N-(cholesterylhemisuccinoyl-amino-3-propyl-N, N-dimethylamine (DMAPA-chems liposome, was incubated with siRNA at different nitrogen-to-phosphate ratios to form stabilized, near-spherical siRNA/DMAPA-chems nanoparticles with sizes of 100–200 nm and zeta potentials of 40–50 mV. The siRNA/DMAPA-chems nanoparticles protected siRNA from nuclease degradation in 25% fetal bovine serum. The nanoparticles exhibited high cell uptake and Notch1 gene knockdown efficiency in SKOV3 cells at an nitrogen-to-phosphate ratio of 100 and an siRNA concentration of 50 nM. They also inhibited the growth and promoted the apoptosis of SKOV3 cells. These results may provide the potential for using cationic cholesterol derivatives as efficient nonviral siRNA carriers for the suppression of Notch1 activation in ovarian cancer cells. Keywords: siRNA, cationic cholesterol derivative, Notch1, ovarian cancer cells

  9. Noninvasive detection of macrophages in atherosclerotic lesions by computed tomography enhanced with PEGylated gold nanoparticles

    Directory of Open Access Journals (Sweden)

    Qin J

    2014-12-01

    Full Text Available Jinbao Qin,1,* Chen Peng,2,* Binghui Zhao,2,* Kaichuang Ye,1 Fukang Yuan,1 Zhiyou Peng,1 Xinrui Yang,1 Lijia Huang,1 Mier Jiang,1 Qinghua Zhao,3 Guangyu Tang,2 Xinwu Lu1,4 1Department of Vascular Surgery, Shanghai Ninth People’s Hospital Affiliated to Shanghai JiaoTong University, School of Medicine; 2Department of Radiology, Shanghai Tenth People’s Hospital Affiliated to Tongji University, School of Medicine; 3Department of Orthopaedics, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University; 4Vascular Center of Shanghai JiaoTong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Macrophages are becoming increasingly significant in the progression of atherosclerosis (AS. Molecular imaging of macrophages may improve the detection and characterization of AS. In this study, dendrimer-entrapped gold nanoparticles (Au DENPs with polyethylene glycol (PEG and fluorescein isothiocyanate (FI coatings were designed, tested, and applied as contrast agents for the enhanced computed tomography (CT imaging of macrophages in atherosclerotic lesions. Cell counting kit-8 assay, fluorescence microscopy, silver staining, and transmission electron microscopy revealed that the FI-functionalized Au DENPs are noncytotoxic at high concentrations (3.0 µM and can be efficiently taken up by murine macrophages in vitro. These nanoparticles were administered to apolipoprotein E knockout mice as AS models, which demonstrated that the macrophage burden in atherosclerotic areas can be tracked noninvasively and dynamically three-dimensionally in live animals using micro-CT. Our findings suggest that the designed PEGylated gold nanoparticles are promising biocompatible nanoprobes for the CT imaging of macrophages in atherosclerotic lesions and will provide new insights into the pathophysiology of AS and other concerned inflammatory diseases. Keywords: atherosclerosis, CT, in vivo

  10. Symptoms and sources of Yersinia enterocolitica-infection: a case-control study

    Directory of Open Access Journals (Sweden)

    Siitonen Anja

    2010-05-01

    Full Text Available Abstract Background Yersinia enterocolitica (YE is the causative agent of yersiniosis. YE encompass strains of diverse pathogenicity: YE biotypes 1B and 2-5 are considered pathogenic, whereas biotype 1A is in general considered nonvirulent. Also YE-like species, which can sometimes be misidentified as YE, are considered nonvirulent. Methods In order to study differences in clinical picture caused by different YE types and their possible sources a case-control study was conducted in 2006. In this case-control study, 295 case-patients with YE or YE-like finding and their 758 controls responded to the questionnaire about symptoms and possible sources of infection. Results Strains of pathogenic YE bio/serotypes 3-4/O:3 or 2/O:9 were found in 18%, YE biotype 1A in 65% and YE -like strains of 17% of the patients. Patients infected with the strains of pathogenic YE bio/serotypes were younger and had fever more often than those with BT 1A who suffered more from vomiting. Symptoms of reactive arthritis were reported by 10% of pathogenic YE infections, 3% of YE BT 1A, and 0.3% of the controls. Eating or tasting raw or medium done pork was a significant risk factor for pathogenic YE bio/serotype infection (OR 6.6; 95% CI 1.7-24.9 as well as eating in a canteen (OR 3.5; 95% CI 1.6-7.9. Imported fruits and berries were associated with increased risk of YE BT 1A finding. Conclusions The symptoms of the patients with YE BT 1A differed from yersiniosis caused by the classic pathogenic YE bio/serotypes. In addition, the patients with YE BT 1A had more protracted gastrointestinal disorders and unspecific complaints. Small children were overrepresented in classic pathogenic bio/serotypes while in BT 1A or YE-like species were not found among children younger than two years. This suggests the lacking virulence of the BT 1A strains. We can not, however, rule out the possibility that some strains of genetically heterogeneous group of BT 1A may cause an illness.

  11. mHealth Series: mHealth project in Zhao County, rural China – Description of objectives, field site and methods

    Science.gov (United States)

    van Velthoven, Michelle Helena; Li, Ye; Wang, Wei; Du, Xiaozhen; Wu, Qiong; Chen, Li; Majeed, Azeem; Rudan, Igor; Zhang, Yanfeng; Car, Josip

    2013-01-01

    Background We set up a collaboration between researchers in China and the UK that aimed to explore the use of mHealth in China. This is the first paper in a series of papers on a large mHealth project part of this collaboration. This paper included the aims and objectives of the mHealth project, our field site, and the detailed methods of two studies. Field site The field site for this mHealth project was Zhao County, which lies 280 km south of Beijing in Hebei Province, China. Methods We described the methodology of two studies: (i) a mixed methods study exploring factors influencing sample size calculations for mHealth–based health surveys and (ii) a cross–over study determining validity of an mHealth text messaging data collection tool. The first study used mixed methods, both quantitative and qualitative, including: (i) two surveys with caregivers of young children, (ii) interviews with caregivers, village doctors and participants of the cross–over study, and (iii) researchers’ views. We combined data from caregivers, village doctors and researchers to provide an in–depth understanding of factors influencing sample size calculations for mHealth–based health surveys. The second study, a cross–over study, used a randomised cross–over study design to compare the traditional face–to–face survey method to the new text messaging survey method. We assessed data equivalence (intrarater agreement), the amount of information in responses, reasons for giving different responses, the response rate, characteristics of non–responders, and the error rate. Conclusions This paper described the objectives, field site and methods of a large mHealth project part of a collaboration between researchers in China and the UK. The mixed methods study evaluating factors that influence sample size calculations could help future studies with estimating reliable sample sizes. The cross–over study comparing face–to–face and text message survey data collection

  12. Livelihoods and Land Uses in Environmental Policy Approaches: The Case of PES and REDD+ in the Lam Dong Province of Vietnam

    Directory of Open Access Journals (Sweden)

    Leif Tore Trædal

    2017-02-01

    Full Text Available This paper explores assumptions about the drivers of forest cover change in a Payments for Environmental Services (PES and Reduced Emissions from Deforestation and Degradation (REDD+ context in the Lam Dong Province in Vietnam. In policy discourses, deforestation is often linked to ‘poor’ and ‘ethnic minority’ households and their unsustainable practices such as the expansion of coffee production (and other agricultural activities into forest areas. This paper applies a livelihood framework to discuss the links between livelihoods and land use amongst small-scale farmers in two communities. The findings of the livelihood survey demonstrate no clear linkages between poverty levels and unsustainable practices. In fact, the poorest segments were found to deforest the least. The ways in which current PES and REDD+ approaches are designed, do not provide appropriate solutions to address the underlying dimensions of issues at stake. The paper criticizes one-dimensional perspectives of the drivers behind deforestation and forest degradation often found in public policies and discourses. We suggest more comprehensive analyses of underlying factors encompassing the entire coffee production and land use system in this region. Addressing issues of land tenure and the scarcity of productive lands, and generating viable off-farm income alternatives seem to be crucial. Sustainable approaches for reducing deforestation and degradation could be possible through engaging with multiple stakeholders, including the business-oriented households in control of the coffee trade and of land transactions.

  13. İtibar Yönetimi Açışından Yeşil Pazarlama: Örnek Olay İncelemesi / Green Marketing in Terms of Reputation Management: A Case Study

    Directory of Open Access Journals (Sweden)

    Samet Kavoğlu

    2012-12-01

    Full Text Available 21.yy modern işletmecilik mantığı çerçevesinde üretimin sorun olmaktan çıktığı, işletmeler için en önemli sıkıntının pazarlama faaliyetleri kapsamında yaşandığı düşünüldüğünde, alana dair çok sayıda yenilikçi fikrin ortaya çıkması oldukça normaldir. Bu fikri akımlar içerisinde yer alan, çalışma kapsamında incelenecek yeşil pazarlama uygulamalarını, diğerlerinden ayıran başlıca özellik pazarlama karması içerisinde yer alan tutundurma faaliyetlerinin her bir faktörüyle ilişkilendirilebilir olmasıdır. Çalışmanın sınırlarını çizebilmek ve derinlemesine araştırma olanağını arttırmak adına araştırma kapsamında yeşil pazarlamanın, tutundurma faaliyetlerinden halkla ilişkilerin, itibar yönetimi fonksiyonuyla olan ilişkisi, ödüllü bir proje olan “Unilever Sürdürülebilir Yaşam Planı” örneği üzerinden incelenmiştir. Çalışmanın sonunda, kuruluşun paydaşları nezdinde itibarını arttırmak gayesiyle hayata geçirilen yeşil pazarlama temalı, küresel ölçekli projenin hedefleri açısından genel değerlendirmesi yapılmıştır. Green Marketing in Terms of Reputation Management: A Case Study When it is taken into account that the production is no longer a problem within the framework of the modern business management logic of the 21st century and the primary difficulty is experienced by the businesses within the scope of the marketing activities, it is natural that a great number of innovative ideas emerge concerning the field. The main characteristic which distinguishes the practices of the green marketing which is in these streams of ideas and which will be examined within the scope of study from others is that they can be associated with each factor of promotional activities in the marketing mix. To be able to draw the lines of the study and to increase the possibility of the in-depth research, within the scope of the research, the relationship of

  14. Střípky dějin – brněnské pracoviště Ústavu pro etnografii a folkloristiku ČSAV v korespondenci Karla Vetterla s Jiřím Horákem

    Czech Academy of Sciences Publication Activity Database

    Bahenská, Marie; Jůnová Macková, Adéla

    2017-01-01

    Roč. 9, č. 2 (2017), s. 63-106 ISSN 1803-9448 R&D Projects: GA ČR GA15-03754S Institutional support: RVO:67985921 Keywords : Karel Vetterl * Jiří Horák * history of ethnology Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  15. Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide fibrous membranes

    Directory of Open Access Journals (Sweden)

    Zhao S

    2014-05-01

    Full Text Available Song Zhao,1,* Jingwen Zhao,3,* Shikui Dong,1 Xiaoqiao Huangfu,1 Bin Li,2,3 Huilin Yang,2,3 Jinzhong Zhao,1 Wenguo Cui2,31Department of Arthroscopic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 2Orthopedic Institute, Soochow University, Suzhou, Jiangsu, 3Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China *These authors contributed equally to this work Abstract: Clinically, rotator cuff tear (RCT is among the most common shoulder pathologies. Despite significant advances in surgical techniques, the re-tear rate after rotator cuff (RC repair remains high. Insufficient healing capacity is likely the main factor for reconstruction failure. This study reports on a basic fibroblast growth factor (bFGF-loaded electrospun poly(lactide-co-glycolide (PLGA fibrous membrane for repairing RCT. Implantable biodegradable bFGF–PLGA fibrous membranes were successfully fabricated using emulsion electrospinning technology and then characterized and evaluated with in vitro and in vivo cell proliferation assays and repairs of rat chronic RCTs. Emulsion electrospinning fabricated ultrafine fibers with a core-sheath structure which secured the bioactivity of bFGF in a sustained manner for 3 weeks. Histological observations showed that electrospun fibrous membranes have excellent biocompatibility and biodegradability. At 2, 4, and 8 weeks after in vivo RCT repair surgery, electrospun fibrous membranes significantly increased the area of glycosaminoglycan staining at the tendon–bone interface compared with the control group, and bFGF–PLGA significantly improved collagen organization, as measured by birefringence under polarized light at the healing enthesis compared with the control and PLGA groups. Biomechanical testing showed that the electrospun fibrous membrane groups had a greater ultimate load-to-failure and stiffness than the control group at 4

  16. The application of click chemistry in the synthesis of agents with anticancer activity

    Directory of Open Access Journals (Sweden)

    Ma N

    2015-03-01

    Full Text Available Nan Ma,1–3 Ying Wang,3 Bing-Xin Zhao,3 Wen-Cai Ye,1,3 Sheng Jiang2 1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 2Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 3Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, People’s Republic of China Abstract: The copper(I-catalyzed 1,3-dipolar cycloaddition between alkynes and azides (click chemistry to form 1,2,3-triazoles is the most popular reaction due to its reliability, specificity, and biocompatibility. This reaction has the potential to shorten procedures, and render more efficient lead identification and optimization procedures in medicinal chemistry, which is a powerful modular synthetic approach toward the assembly of new molecular entities and has been applied in anticancer drugs discovery increasingly. The present review focuses mainly on the applications of this reaction in the field of synthesis of agents with anticancer activity, which are divided into four groups: topoisomerase II inhibitors, histone deacetylase inhibitors, protein tyrosine kinase inhibitors, and antimicrotubule agents. Keywords: topoisomerase II inhibitors, histone deacetylase inhibitors, protein tyrosine kinase inhibitors, antimicrotubule agents

  17. Comprehensive analysis of differential co-expression patterns reveal transcriptional dysregulation mechanism and identify novel prognostic lncRNAs in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Li Z

    2017-06-01

    Full Text Available Zhen Li,1 Qianlan Yao,1 Songjian Zhao,1 Yin Wang,2,3 Yixue Li,1,4 Zhen Wang4 1School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 2Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, 3Collaborative Innovation Center for Genetics and Development, Fudan University, 4Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China Abstract: Esophageal squamous cell carcinoma (ESCC is one of the most common malignancies worldwide and occurs at a relatively high frequency in People’s Republic of China. However, the molecular mechanism underlying ESCC is still unclear. In this study, the mRNA and long non-coding RNA (lncRNA expression profiles of ESCC were downloaded from the Gene Expression Omnibus database, and then differential co-expression analysis was used to reveal the altered co-expression relationship of gene pairs in ESCC tumors. A total of 3,709 mRNAs and 923 lncRNAs were differentially co-expressed between normal and tumor tissues, and we found that most of the gene pairs lost associations in the tumor tissues. The differential regulatory networking approach deciphered that transcriptional dysregulation was ubiquitous in ESCC, and most of the differentially regulated links were modulated by 37 TFs. Our study also found that two novel lncRNAs (ADAMTS9-AS1 and AP000696.2 might be essential in the development of ectoderm and epithelial cells, which could significantly stratify ESCC patients into high-risk and low-risk groups, and were much better than traditional clinical tumor markers. Further inspection of two risk groups showed that the changes in TF-target regulation in the high-risk patients were significantly higher than those in the low-risk patients. In addition, four signal transduction-related DCmRNAs (ERBB3, ENSA, KCNK7, MFSD5

  18. Production of high concentration of l-lactic acid from oil palm empty fruit bunch by thermophilic Bacillus coagulans JI12.

    Science.gov (United States)

    Juturu, Veeresh; Wu, Jin Chuan

    2018-03-01

    Thermophilic Bacillus coagulans JI12 was used to ferment hemicellulose hydrolysate obtained by acid hydrolysis of oil palm empty fruit bunch at 50 °C and pH 6, producing 105.4 g/L of l-lactic acid with a productivity of 9.3 g/L/H by fed-batch fermentation under unsterilized conditions. Simultaneous saccharification and fermentation (SSF) was performed at pH 5.5 and 50 °C to convert both hemicellulose hydrolysate and cellulose-lignin complex in the presence of Cellic Ctec2 cellulases using yeast extract (20 g/L) as the nitrogen source, giving 114.0 g/L of l-lactic acid with a productivity of 5.7 g/L/H. The SSF was also conducted by replacing yeast extract with equal amount of dry Bakers' yeast, achieving 120.0 g/L of l-lactic acid with a productivity of 4.3 g/L/H. To the best of our knowledge, these lactic acid titers and productivities are the highest ever reported from lignocellulose hydrolysates. © 2017 International Union of Biochemistry and Molecular Biology, Inc.

  19. Bibliography of Soviet Laser Developments, Number 55. September-October 1981.

    Science.gov (United States)

    1983-01-01

    Boldeskul , I.Ye., and A.Ye. Boldeskul (0). Fluorescence and resonant R-amanspctra1 probes in studies on the dynamics of biological and micellar...AKAYEV A 45 BOLDESKUL I YE 72 AKHMANOV S A 87 PAPADZHAN YE 1 79 BOLGAROV L N 11 AKHMEDZHANOV I M 24 BABARSKOV YE V 84 BOL’SHOV L A 84 AKHSAKHALYAN A D

  20. Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersinia enterocolitica.

    Science.gov (United States)

    Drechsler-Hake, Doreen; Alamir, Hanin; Hahn, Julia; Günter, Manina; Wagner, Samuel; Schütz, Monika; Bohn, Erwin; Schenke-Layland, Katja; Pisano, Fabio; Dersch, Petra; Autenrieth, Ingo B; Autenrieth, Stella E

    2016-09-01

    Enteropathogenic Yersinia enterocolitica (Ye) enters the host via contaminated food. After colonisation of the small intestine Ye invades the Peyer's patches (PPs) via M cells and disseminates to the mesenteric lymph nodes (MLNs), spleen and liver. Whether Ye uses other invasion routes and which pathogenicity factors are required remains elusive. Oral infection of lymphotoxin-β-receptor deficient mice lacking PPs and MLNs with Ye revealed similar bacterial load in the spleen 1h post infection as wild-type mice, demonstrating a PP-independent dissemination route for Ye. Immunohistological analysis of the small intestine revealed Ye in close contact with mononuclear phagocytes (MPs), specifically CX3CR1(+) monocyte-derived cells (MCs) as well as CD103(+) dendritic cells (DCs). This finding was confirmed by flow cytometry and imaging flow cytometry analysis of lamina propria (LP) leukocytes showing CD103(+) DCs and MCs with intracellular Ye. Uptake of Ye by LP CD103(+) DCs and MCs was dependent on the pathogenicity factor invasin, whereas the adhesin YadA was dispensable as demonstrated by Ye deletion mutants. Furthermore, Ye were found exclusively associated with CD103(+) DCs in the MLNs from wild-type mice, but not from CCR7(-/-) mice, demonstrating a CCR7 dependent transport of Ye by CD103(+) DCs from LP to the MLNs. In contrast, dissemination of Ye to the spleen was dependent on MCs as significantly less Ye could be recovered from the spleen of CX3CR1(GFP/GFP) mice compared to wild-type mice. Altogether, MCs and CD103(+) DCs contribute to immediate invasion and dissemination of Ye. This together with data from other bacteria suggests MPs as general pathogenic entry site in the intestine. Copyright © 2016 Elsevier GmbH. All rights reserved.

  1. Black Hole on a Chip: Proposal for a Physical Realization of the Sachdev-Ye-Kitaev model in a Solid-State System

    Directory of Open Access Journals (Sweden)

    D. I. Pikulin

    2017-07-01

    Full Text Available A system of Majorana zero modes with random infinite-range interactions—the Sachdev-Ye-Kitaev (SYK model—is thought to exhibit an intriguing relation to the horizons of extremal black holes in two-dimensional anti–de Sitter space. This connection provides a rare example of holographic duality between a solvable quantum-mechanical model and dilaton gravity. Here, we propose a physical realization of the SYK model in a solid-state system. The proposed setup employs the Fu-Kane superconductor realized at the interface between a three-dimensional topological insulator and an ordinary superconductor. The requisite N Majorana zero modes are bound to a nanoscale hole fabricated in the superconductor that is threaded by N quanta of magnetic flux. We show that when the system is tuned to the surface neutrality point (i.e., chemical potential coincident with the Dirac point of the topological insulator surface state and the hole has sufficiently irregular shape, the Majorana zero modes are described by the SYK Hamiltonian. We perform extensive numerical simulations to demonstrate that the system indeed exhibits physical properties expected of the SYK model, including thermodynamic quantities and two-point as well as four-point correlators, and discuss ways in which these can be observed experimentally.

  2. Nuclear Structure in China 2010

    Science.gov (United States)

    Bai, Hong-Bo; Meng, Jie; Zhao, En-Guang; Zhou, Shan-Gui

    2011-08-01

    Personal view on nuclear physics research / Jie Meng -- High-spin level structures in [symbol]Zr / X. P. Cao ... [et al.] -- Constraining the symmetry energy from the neutron skin thickness of tin isotopes / Lie-Wen Chen ... [et al.] -- Wobbling rotation in atomic nuclei / Y. S. Chen and Zao-Chun Gao -- The mixing of scalar mesons and the possible nonstrange dibaryons / L. R. Dai ... [et al.] -- Net baryon productions and gluon saturation in the SPS, RHIC and LHC energy regions / Sheng-Qin Feng -- Production of heavy isotopes with collisions between two actinide nuclides / Z. Q. Feng ... [et al.] -- The projected configuration interaction method / Zao-Chun Gao and Yong-Shou Chen -- Applications of Nilsson mean-field plus extended pairing model to rare-earth nuclei / Xin Guan ... [et al.] -- Complex scaling method and the resonant states / Jian-You Guo ... [et al.] -- Probing the equation of state by deep sub-barrier fusion reactions / Hong-Jun Hao and Jun-Long Tian -- Doublet structure study in A[symbol]105 mass region / C. Y. He ... [et al.] -- Rotational bands in transfermium nuclei / X. T. He -- Shape coexistence and shape evolution [symbol]Yb / H. Hua ... [et al.] -- Multistep shell model method in the complex energy plane / R. J. Liotta -- The evolution of protoneutron stars with kaon condensate / Ang Li -- High spin structures in the [symbol]Lu nucleus / Li Cong-Bo ... [et al.] -- Nuclear stopping and equation of state / QingFeng Li and Ying Yuan -- Covariant description of the low-lying states in neutron-deficient Kr isotopes / Z. X. Li ... [et al.] -- Isospin corrections for superallowed [symbol] transitions / HaoZhao Liang ... [et al.] -- The positive-parity band structures in [symbol]Ag / C. Liu ... [et al.] -- New band structures in odd-odd [symbol]I and [symbol]I / Liu GongYe ... [et al.] -- The sd-pair shell model and interacting boson model / Yan-An Luo ... [et al.] -- Cross-section distributions of fragments in the calcium isotopes projectile

  3. Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats

    Directory of Open Access Journals (Sweden)

    Qian-ying Guo

    2015-12-01

    Full Text Available BT799 is a genetically modified (GM maize plant that expresses the Cry1Ac gene from Bacillus thuringiensis (Bt. The Cry1Ac gene was introduced into maize line Zhen58 to encode the Bt crystal protein and thus produce insect-resistant maize BT799. Expression of Bt protein in planta confers resistance to Lepidopteran pests and corn rootworms. The present study was designed to investigate any potential effects of BT799 on the reproductive system of male rats and evaluate the nutritional value of diets containing BT799 maize grain in a 90-day subchronic rodent feeding study. Male Wistar rats were fed with diets containing BT799 maize flours or made from its near isogenic control (Zhen58 at a concentration of 84.7%, nutritionally equal to the standard AIN-93G diet. Another blank control group of male rats were treated with commercial AIN-93G diet. No significant differences in body weight, hematology and serum chemistry results were observed between rats fed with the diets containing transgenic BT799, Zhen58 and the control in this 13-week feeding study. Results of serum hormone levels, sperm parameters and relative organ/body weights indicated no treatment-related side effects on the reproductive system of male rats. In addition, no diet-related changes were found in necropsy and histopathology examinations. Based on results of the current study, we did not find any differences in the parameters tested in our study of the reproductive system of male rats between BT799 and Zhen58 or the control.

  4. Report on a survey in fiscal 1999. Survey and study on the 'measures for promoting discharge right transaction/joint implementation (JI) / clean development mechanism (CDM) project'; 1999 nendo 'haishutsuken torihiki / JI / CDM project suishin hosaku' ni kansuru chosa kenkyu hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The third conference (COP3) of the United Nations Framework Convention on Climate Change held in December 1997 in Kyoto has adopted the Kyoto mechanisms (the 'discharge right transaction', the 'joint implementation (JI)' among advanced countries, and the 'clean development mechanism (CDM)' applied to developing countries). The Kyoto mechanisms are intended to provide flexibility to the methods to achieve the greenhouse effect gas reduction targets established in the Kyoto Protocol. The Kyoto mechanisms are considered to be implemented even during the year 2000, whose details are scheduled to be decided at COP6. Since the advanced countries have established the targets for reduction of greenhouse effect gas emission, governments and research institutes are taking various approaches. In addition, since the targets for reduction of greenhouse effect gas emission have been established, discussions are indispensable on methodology to establish the quantity of discharge and absorption of greenhouse effect gases (the so-called base line) when no project exists, as required to calculate the discharge reduction quantity as a result of implementing the project. The present survey has held study meetings attended by learned people, and compiled the results of the discussions. (NEDO)

  5. from left to right : Mr Michel Della Negra (Last spokeperson of CMS), Prof. Tejinder ("Jim") Virdee (actual spokeperson of CMS), Mr Robert Aymar (CERN Director General) and Mr Sigurd Lettow (Chief Financial Officer of CERN) assist to the Lowering of the final element (YE-1) of the Compact Muon Solenoid (CMS) detector into its underground experimental cavern.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    from left to right : Mr Michel Della Negra (Last spokeperson of CMS), Prof. Tejinder ("Jim") Virdee (actual spokeperson of CMS), Mr Robert Aymar (CERN Director General) and Mr Sigurd Lettow (Chief Financial Officer of CERN) assist to the Lowering of the final element (YE-1) of the Compact Muon Solenoid (CMS) detector into its underground experimental cavern.

  6. Role of β1 integrins and bacterial adhesins for Yop injection into leukocytes in Yersinia enterocolitica systemic mouse infection.

    Science.gov (United States)

    Deuschle, Eva; Keller, Birgit; Siegfried, Alexandra; Manncke, Birgit; Spaeth, Tanja; Köberle, Martin; Drechsler-Hake, Doreen; Reber, Julia; Böttcher, Ralph T; Autenrieth, Stella E; Autenrieth, Ingo B; Bohn, Erwin; Schütz, Monika

    2016-02-01

    Injection of Yersinia outer proteins (Yops) into host cells by a type III secretion system is an important immune evasion mechanism of Yersinia enterocolitica (Ye). In this process Ye invasin (Inv) binds directly while Yersinia adhesin A (YadA) binds indirectly via extracellular matrix (ECM) proteins to β1 integrins on host cells. Although leukocytes turned out to be an important target of Yop injection by Ye, it was unclear which Ye adhesins and which leukocyte receptors are required for Yop injection. To explain this, we investigated the role of YadA, Inv and β1 integrins for Yop injection into leukocytes and their impact on the course of systemic Ye infection in mice. Ex vivo infection experiments revealed that adhesion of Ye via Inv or YadA is sufficient to promote Yop injection into leukocytes as revealed by a β-lactamase reporter assay. Serum factors inhibit YadA- but not Inv-mediated Yop injection into B and T cells, shifting YadA-mediated Yop injection in the direction of neutrophils and other myeloid cells. Systemic Ye mouse infection experiments demonstrated that YadA is essential for Ye virulence and Yop injection into leukocytes, while Inv is dispensable for virulence and plays only a transient and minor role for Yop injection in the early phase of infection. Ye infection of mice with β1 integrin-depleted leukocytes demonstrated that β1 integrins are dispensable for YadA-mediated Yop injection into leukocytes, but contribute to Inv-mediated Yop injection. Despite reduced Yop injection into leukocytes, β1 integrin-deficient mice exhibited an increased susceptibility for Ye infection, suggesting an important role of β1 integrins in immune defense against Ye. This study demonstrates that Yop injection into leukocytes by Ye is largely mediated by YadA exploiting, as yet unknown, leukocyte receptors. Copyright © 2015. Published by Elsevier GmbH.

  7. Occurrence of cavernicolous ground beetles in Anhui Province, eastern China (Coleoptera, Carabidae, Trechinae).

    Science.gov (United States)

    Fang, Jie; Li, Wenbo; Tian, Mingyi

    2016-01-01

    Two new species of anophthalmic ground beetles belonging to the subfamily Trechinae are described: Cimmeritodes (Zhecimmerites) parvus Tian & Li, sp. n. and Wanoblemus wui Tian & Fang, gen. n., sp. n. Both were discovered in the limestone caves of Anhui Province in eastern China. Cimmeritodes (Zhecimmerites) parvus was found in caves Ziwei Dong, Xianren Dong and Qingtai Dong, whereas Wanoblemus wui was discovered in cave Baiyun Dong. This is the first record of cavernicolous ground beetles in Anhui Province, eastern China.

  8. Occurrence of cavernicolous ground beetles in Anhui Province, eastern China (Coleoptera, Carabidae, Trechinae

    Directory of Open Access Journals (Sweden)

    Jie Fang

    2016-10-01

    Full Text Available Two new species of anophthalmic ground beetles belonging to the subfamily Trechinae are described: Cimmeritodes (Zhecimmerites parvus Tian & Li, sp. n. and Wanoblemus wui Tian & Fang, gen. n., sp. n. Both were discovered in the limestone caves of Anhui Province in eastern China. C. (Z. parvus was found in caves Ziwei Dong, Xianren Dong and Qingtai Dong, whereas W. wui was discovered in cave Baiyun Dong. This is the first record of cavernicolous ground beetles in Anhui Province, eastern China.

  9. Tao Dong | NREL

    Science.gov (United States)

    -7986 Orcid ID http://orcid.org/0000-0002-4961-7576 Research Interests Microbial biomass characterization, fractionation, and conversion Affiliated Research Programs Algal Biomass Conversion Biogas to (2015) "Regulation of Starch and Lipid Accumulation in a Microalga Chlorella Sorokiniana,"

  10. Yield efficiency for nine apple cultivars grafted on two rootstocks

    Directory of Open Access Journals (Sweden)

    João Caetano Fioravanço

    Full Text Available ABSTRACT: Currently, using smaller trees is one of the most important trends in apple cultivation. It is expected that reduced size plants produce lower amount of fruit, but with high yield and yield efficiency. The aim of this study was to evaluate the yield efficiency (YE of nine apple tree cultivars, grafted on two rootstocks, from the second to the seventh year after planting. The YE indexes oscillated from one to the other year, regardless of rootstock. Correlations between YE and yield per tree and between YE and trunk cross sectional area (TCSA confirmed that efficiency can be increased by the production increment or by the plant's vigor reduction. The usefulness of cumulative YEYE is highlighted to compare apple tree cultivars after the third year of production. The highest ƩYE indexes were observed for 'Royal Gala' and 'Baigent', on M-9 rootstock, and for 'Gala Real' and 'Maxi-Gala', on Marubakaido/M-9 rootstock.

  11. Multilocular Hepatic Abscess Formation and Sepsis due to Yersinia enterocolitica in a Patient with Hereditary Hemochromatosis and Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Matthias Sauter

    2017-11-01

    Full Text Available Infection with Yersinia enterocolitica (YE typically presents with mild gastroenteritis without systemic infection. However, systemic YE infection has been described in states of iron overload. We present the case of a patient with sepsis with hepatic abscesses due to YE infection. Workup revealed a past diagnosis of diabetes mellitus and hemochromatosis which had been untreated for the previous 5 years due to patient refusal. This case highlights risk factors for systemic infection with YE. A high degree of suspicion for YE infection is warranted in patients with iron overload, diabetes mellitus, or immunosuppression.

  12. Impacts of Land-Use and Land-Cover Changes on Water Yield: A Case Study in Jing-Jin-Ji, China

    Directory of Open Access Journals (Sweden)

    Suxiao Li

    2018-03-01

    Full Text Available Knowing the impact of land-use and land-cover (LULC changes on the distribution of water yield (WY is essential for water resource management. Using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST model, we investigated the spatial-temporal variations of WY from 1990 to 2015 in China’s northern semi-arid region of Beijing–Tianjin–Hebei (Jing-Jin-Ji. We quantified the combined effects of LULC dynamics and climatic variation on WY. Furthermore, we identified the relative contribution of main LULC types to WY. For our study region, the built-up area increased by 35.66% (5380 km2 during the study period. In the meantime, cropland, grassland, and wetland decreased continuously. The expansion of built-up area and decline of vegetated land led to an increase of 1047 million m3 (5.1% in total WY. The impacts of LULC changes on WY were mainly determined by the biophysical characteristics of LULC composition. Vegetated land has relatively lower WY coefficients due to higher rates of evapotranspiration and water infiltration. Built-up areas and bare land have higher WY coefficients as a result of their impermeable surface. The spatial-temporal analysis of WY with specification of WY coefficients by LULC types can facilitate integrated land-use planning and water resource management.

  13. Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang

    Directory of Open Access Journals (Sweden)

    Tung-Yuan Lai

    2016-04-01

    Full Text Available Sha Shen Mai Men Dong Tang (SMD-2; 沙參麥冬湯 shā shēn mài dōng tāng is a Chinese medicinal herb (CMH; 中草藥 zhōng cǎo yào used to treat symptoms associated with cancer therapy. The objective of this study was to assess the effect of SMD-2 on the levels of urinary copper (Cu, zinc (Zn, and selenium (Se in lung cancer patients and head and neck cancer patients receiving chemoradiotherapy. Forty-two head and neck cancer patients and 10 lung cancer patients participated in our clinical trial. Each patient received chemoradiotherapy for 4 weeks. In addition, each patient was treated with SMD-2 for 8 weeks, including 2 weeks prior to and after the chemoradiotherapy treatment. Comparison of urinary Cu, Zn, and Se levels and the ratios of Zn to Cu and Se to Cu at three time points in the two types of cancer were assessed using the generalized estimating equations (GEEs. After the patients received chemoradiotherapy for 4 weeks, SMD-2 treatment was found to be associated with a significant decrease in urinary Cu levels, whereas urinary Zn and Se levels increased significantly. In addition, the ratios of Zn to Cu and Se to Cu in the urine samples of these patients also increased significantly. Both the urinary Zn levels and the ratio of Zn to Cu in head and neck cancer patients were significantly higher than in lung cancer patients. Urinary Zn and Se levels and the ratios of Zn to Cu and Se to Cu, but not urinary Cu levels, increased significantly during and after treatment when assessed using the GEE model. The SMD-2 treatments significantly increased Zn and Se levels in the urine of head and neck cancer patients. Increased Zn and Se levels in urine strengthened immune system.

  14. AHMEDİYE FLOATING ISLAND AHMEDİYE YÜZENADASI

    Directory of Open Access Journals (Sweden)

    Pınar TAŞKIRAN (M.A.H.

    2006-09-01

    Full Text Available Floating islands arouse the attention of the scientists with their various featuers. Primarily, they can be distinguished from their environment with their rich flora and fauna. Since they generally emerge in the lakes as wetlands they always keep the eyes of the people on themselwes. These wetlands are also the most suitable places to observe the corruptions in the ecosystem both by natural and homone factors. Not only the optimum mixture of inorganic and organic minerals under the favorable climatic circumstances are taking places in these marshes, but also dense and rich wetland plants grow in these places due to phosphate that takes place in inorganic minerals and nitrate taken from the atmosphere. In our country, the number of the cities having floating islands is 8. but in various districts of our country there are anumber of marshes and wetlands in various sizes. So, since the researches expand, the number of floating islands wiil grow. An example to the recently discovered floating islands is Ahmediye Floating Island. Having been in the territory of Erzincan City. Ahmediye Floating Island have many different features. At the some time, it is biggest floating island known not only in our country but also in the world. Another interesting point related to this island is; although it is very close to the city centre of Erzincan, it has not been realized or discovered by the people. Even the the residents of the Ahmetli (Ahmediye village in which this floating island exists do not have any information about it. This acpects did not escape notice dwing our researches in the region. On the other hand, the villagers interfere the ecosystem of the lake in which the floating island takes place; by opening a canal on the South side of the lake in order to prevent the expansion of the lake when the water level rises. Oluşumları ve gelişimleri bakımından oldukça ilginç özelliklere sahip olan yüzenadalar, son yıllarda çeşitli bilim dallarının inceleme konusu olmuştur. Söz konusu oluşum, başta coğrafya olmak üzere biyoloji, jeoloji ve çevre bilimlerinin de inceleme alanına girmektedir. Ancak yüzenada terimi Coğrafya ilmi sayesinde literatüre girmişve adaların oluşumu, tanımı ve tanıtımı üzerine ilk çalışmalar yine coğrafyacılar tarafından yapılmıştır. Bu konuda Prof. Dr. İhsan BULUT’ un önemli çalışmalarıbulunmaktadır. Yüzenadalar çok çeşitli özellikleri ile bilim dünyasının dikkatini çekmektedir. Başta zengin flora ve faunasıyla içerisinde bulunduğu ortamdan belirgin bir şekilde ayrılmaktadır. Bu adalar, göl alanı içerisinde gelişmeleri dolayısıyla,insanların hep dikkatini çeken sulak alanlar durumundadır. Doğal ve beşerî faktörlerle ekosistemde meydana gelen bozulmaların en bariz olarak gözlenebildiği kesimler yine bu sulak alanlardır. İnorganik ve organik minerallerin uygun iklim koşulları altında optimum karışımı yine sulak alanlarda gerçekleşirken, inorganik minerallerde bulunan fosfat ve serbest atmosferden sağlanan nitratla gür ve türce zengin sulak alan bitkileri yetişmektedir. Yüzenadalar hemen her iklim kuşağında görülmesine rağmen yine de dünyamızın bu oluşumlar bakımından fakir olduğu söylenebilir. Ancak bu durum, şüphesiz bu alandaki çalışmaların yetersiz olmasının bir sonucudur. Kendine özgü doğal ortamıyla çevresinden ayrılan ve göl alanında yüzer halde her yöne kolayca hareket edebilen yüzenadalar, çevrelerinin adeta bir sembolü rolünü üstlenirken, bölge insanını kendisine çeken görsel doğal bir turistik cazibe merkezi olma özelliğini de taşırlar. Ülkemizde kayıtlara geçen yüzenada bulunan il sayısı 8’dir. Ancak ülkemizin farklı kesimlerinde büyüklü küçüklü çok sayıda sulak alan bulunmaktadır. Dolayısıyla da araştırmalar arttıkça farklı kesimlerde yüzenadalarla karşılaşılacaktır. İşte bilinenlere ilave edebileceğimiz bir örnek de Ahmediye Yüzenadası’dır. Erzincan ili sınırları içerisinde bulunan Ahmediye Yüzenadası çok farklı özelliklere sahiptir. Aynı zamanda ülkemizde ve dünyanın çeşitli kesimlerinde şimdiye kadar bilinen yüzenadalar içerisinde en büyük yüzenada olma özelliğini taşımaktadır. Bir başka dikkat çekici özelliği de Erzincan şehir merkezine çok yakın olmasına rağmen yöre halkı tarafından fark edilememiş oluşudur. Hatta sınırları içerisinde bulunduğu Ahmetli (Ahmediye köyü sakinlerinin dahi göldeki yüzenadadan haberdar olmayışıilgi çekici bir durumdur. Bu husus, yörede yaptığımız arazi çalışmaları esnasında dikkatlerden kaçmamıştır. Ancak köy halkı, göldeki su seviyesinin yüksek olduğu dönemlerde gölün alanının genişlemesini engellemek amacıyla, gölün güney kesimine bir ark açmak suretiyle suni bir gidegenle göl ekosistemine müdahale etmişlerdir. Bu çalışmamızla Ahmediye Yüzenadası çeşitli yönleriyle incelenmiş, adanın Erzincan ilinin tanıtımında yerini alması ve korunması gereken sulak alanlar içerisinde değerlendirilmesi amaçlanmıştır.

  15. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats.

    Science.gov (United States)

    Wu, Xinying; Gu, Ye; Li, Lun

    2017-01-04

    Qing Ye Dan (QYD) is the whole plant of Swertia mileensis and used in Chinese folk medicine for the treatment of prostatitis, benign prostatic hyperplasia (BPH) and so on. This study was to investigate the effects of QYD and its main component swertiamarin on BPH induced by testosterone in rats. The prostatic expressions of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic fibroblast growth factor (βFGF) and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemistry assay. Prostatic levels of oxidative stress and inflammatory-related factors were also analyzed. Additionally, the prostatic expressions of androgen receptor (AR), estrogen receptor (ER)-α, ER-β, hypoxia-inducible factor (HIF)-1α, B-cell CLL/lymphoma (Bcl)-2 and Bcl-2-associated X protein (Bax) were measured by western blot. The epithelial-mesenchymal transition (EMT) associated factors were evaluated by quantitative RT-PCR. It showed that QYD and swertiamarin ameliorated the testosterone-induced prostatic hyperplasia and collagen deposition, attenuated the over-expressions of HIF-1α, VEGF, EGF, βFGF, PCNA, AR and ER-α, reduced the ratio of Bcl-2/Bax, enhanced the expression of ER-β, inhibited the oxidative stress and local inflammation, as well as relieved prostatic EMT. It suggested that QYD and swertiamarin had prostatic protective potential against BPH. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Tarla Tarımı Yapılan Toprakların Meyve Yetiştiriciliğine Uygunluğunun Araştırılması: Yeşilsırt Köyü Örneği

    Directory of Open Access Journals (Sweden)

    Korkmaz BELLİTÜRK

    2014-09-01

    Full Text Available Yeşilsırt, Tekirdağ ilinin Muratlı ilçesine bağlı bir köydür. Ekonomisi tarım ve hayvancılığa dayanan köyde daha çok buğday ve ayçiçeği ekiminde kullanılan tarım arazilerinde meyvecilik, ilçe merkezinde olduğu gibi çok küçük bir paya sahiptir. İklim özellikleri bakımından meyve yetiştiriciliğine uygun olan ve sulama suyu sıkıntısı olmayan bu bölgenin buğday ve ayçiçeği ekimi yapılan tarım alanlarından alınan 26 adet toprak örneğinin fiziksel ve kimyasal özellikleri değerlendirilerek, bu toprakların meyveciliğe uygun olup olmadığı sorgulanmıştır. Analiz sonuçlarına göre, toprakların pH değerleri elma, armut, erik ve kiraz yetiştirilmesi için uygundur. Fosfor, demir ve bakır bakımından iyi durumda olan topraklarda azot eksikliği mevcuttur. Toprakların yarısından fazlasında potasyum, mangan ve çinko eksikliği olduğu tespit edilmiş olup organik içerikli gübrelerle eksiklik giderilebilir. Toprakların tüm fiziksel ve kimyasal özellikleri dikkate alındığında, Yeşilsırt köyü topraklarının elma, armut, erik ve kiraz yetiştiriciliğine uygun olduğu saptanmıştır

  17. [Nomenclature of Feiyang (BL 58) and its connotation exploration based on A-B Classic of Acupuncture and Moxibustion].

    Science.gov (United States)

    Feng, Shuangshuang; Hou, Zhongwei

    2018-04-12

    A - B Classic of Acupuncture and Moxibustion ( Zhen Jiu Jia Yi Jing ) is the earliest and existed well-known work on acupuncture and moxibustion, with irreplaceable literature values and huge impacts on the later generations. Feiyang (BL 58) is the luo -connecting point of the bladder meridian and recorded 11 times in A - B Classic of Acupuncture and Moxibustion . This book is the representative for the exploration on the acupoint nomenclature and clinical connotation. Through the investigation on the textual connotation of the specified terms and the alias of Feiyang (BL 58), it was discovered that the nomenclature of this acupoint was based on the main symptoms, the characters of the running course of meridian and acupuncture effects. It was proved that the unique property of this acupoint was as rising, dispersing and flying of meridian qi . In comparison of Huangdi Three - Version of A - B Classic of Acupuncture and Moxibustion ( Huangdi Sanbu Zhen Jiu Jia Yi Jing ) of the printed edition of the Song Dynasty version and Meridian - Collateral and Acupoints ( Zhen Jiu Shu Xue Xue ), it was found that the indications and connotation of Feiyang (BL 58) were more extensively richer than the records in teaching materials. Those study results contribute to the extension of the clinical application of this acupoint.

  18. Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease

    DEFF Research Database (Denmark)

    Brix, Thomas H; Hansen, Pia S; Hegedüs, Laszlo

    2008-01-01

    BACKGROUND: Yersinia enterocolitica (YE) infection has long been implicated in the pathogenesis of Graves' disease (GD). The association between YE and GD could, however, also be due to common genetic or environmental factors affecting the development of both YE infection and GD. This potential...

  19. Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)

    OpenAIRE

    Vismane, Inese

    2010-01-01

    Maģistra darba tēma ir „Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)”. Darba mērķis ir izpētīt Latvijas interneta sociālo tīklu vidi kā potenciāli augošu un reklāmai piemērotu, kā arī izpētīt pamanāmākos reklāmas gadījumus šajos portālos. Teorijas daļā tiek apskatīta Web 2.0 ēra, interneta reklāmas un sociālo mediju mārketinga īpatnības, sociālo tīklu fenomens un teorijas, Latvijas reklāmas tirgus un auditorija, kā arī sociāl...

  20. Situation of the Kinh poor and minority women and their use of the Maternal Care and Family Planning Service in Nam Dong Mountainous District, Thuathien-Hue Province, Vietnam.

    Science.gov (United States)

    Vo Van, T; Hoat, L N; Jan van Schie, T

    2004-01-01

    This study aimed to determine the barriers to the use of maternal care and family planning (MCFP) services by the disadvantaged Kinh people and Katu ethnic minority people in the remote and mountainous area of Nam Dong District in Central Vietnam. A survey was conducted using a random sample of 420 mothers with at least one child under the age of 5 years. These data were supplemented by interviews with key informants, focus group discussions and observations. Many barriers were identified. The difficulty of the terrain made travel to healthcare centers difficult. The cost of treatment was a barrier for the poorest people. The quality of the services and facilities, as well as the management of these services was perceived to be unsatisfactory. Traditional practices were often described as being contrary to the doctor's advice, and were presented as the reason for unsafe and unassisted home deliveries. Communication was difficult because of the minority languages of the client groups, the prevalence of illiteracy, and the absence of mass communication in this region. Finally, consulting a male healthcare worker was reported to bring the women shame. There is an urgent need for the MCFP services to build both clinical capacity and health promotion activities in a way that is gender sensitive, cognisant of traditional practices and accessible by both illiterate and minority language speaking people.

  1. ORTA VE DOĞU AVRUPA ÜLKELERİ AB’YE GİREREK ÜRETİM VE FİNANS KAPİTALİZMİNDE İLERLEME KAYDETTİLER Mİ? (WERE CENTRAL AND EASTERN EUROPEAN COUNTRIES ABLE TO MAKE PROGRESS BY BEING FULL MEMBERS OF THE EU?

    Directory of Open Access Journals (Sweden)

    Bülent DOĞRU

    2013-10-01

    Full Text Available ÖZ: Orta ve Doğu Avrupa Ülkeleri (CEE Estonya, Slovakya, Slovenya, Letonya, Polonya, Litvanya, Çek Cumhuriyeti ve Macaristan Avrupa Birliği ile sürdürdükleri müzakere sürecini bitirerek, 1 Mayıs 2004 tarihinde toplu halde Birliğe tam üye oldular. Çoğunluğu eski Sosyalist Bloku üyeleri olan bu ülkeler, AB’ye girerek kapitalist piyasa nimetlerinden faydalanmaya çalıştılar. Bu çalışma, geçen yedi yıllık süreçte bu ülkelerin amaçlarına hangi ölçüde ulaştıklarını incelemektedir. Çalışmada kullanılan kapitalizmin temel göstergeleri Mehmet Altan’ın “Kapitalizm Bu Köye Uğramadı” çalışmasında geçen ve Türkiye için kabul ettiği makroekonomik değişkenlerdir. Bu değişkenler, özel sektör istihdam oranı, özel sektör üretiminin toplam üretim içindeki payı, ticaretin toplam hâsıla içindeki payı, yabancı banka sayısındaki artış, özel yatırımların toplam hâsıla içindeki payı, şehirleşme oranı, borsa kapitalizasyonudur. Özel sektör ve yabancı sermaye itişli bu makroekonomik değişkenlerin CEE ülkeler için 2004 sonrası dönemde pozitif yönde anlamlı bir farklılaşma gösterip göstermediği analiz edilmiştir. Elde edilen sonuçlara göre, AB’ye girmek bu ülkelere ticaretlerini arttırma imkânı tanımış ve ticaret kapitalizminde ciddi bir ilerleme kaydetmelerine sebep olmuştur. Ancak üretim kapitalizmi ve finans kapitalizmi alanlarında ilerlemenin olduğuna dair güçlü delil bulunamamıştır. Anahtar Kelimeler: Kapitalizm, Bölgesel Ekonomik Topluluklar, Orta ve Doğu Avrupa Ülkeleri Ekonomileri. ABSTRACT: Central and Eastern European countries, Estonia, Slovakia, Slovenia, Latvia, Poland, Lithuania, the Czech Republic and Hungary, became full members of the European Union on 1 May 2004 after completing the process of accession negotiations. These countries, mostly past member of the Communist Bloc, tried to utilize the benefits of the

  2. Efficiently and easily integrating differential equations with JiTCODE, JiTCDDE, and JiTCSDE

    Science.gov (United States)

    Ansmann, Gerrit

    2018-04-01

    We present a family of Python modules for the numerical integration of ordinary, delay, or stochastic differential equations. The key features are that the user enters the derivative symbolically and it is just-in-time-compiled, allowing the user to efficiently integrate differential equations from a higher-level interpreted language. The presented modules are particularly suited for large systems of differential equations such as those used to describe dynamics on complex networks. Through the selected method of input, the presented modules also allow almost complete automatization of the process of estimating regular as well as transversal Lyapunov exponents for ordinary and delay differential equations. We conceptually discuss the modules' design, analyze their performance, and demonstrate their capabilities by application to timely problems.

  3. The effects of Tai Ji Quan training on limits of stability in older adults

    Directory of Open Access Journals (Sweden)

    Li F

    2014-08-01

    Full Text Available Fuzhong Li1,2 1Oregon Research Institute, Eugene, OR, USA; 2Shanghai University of Sport, Shanghai, People’s Republic of ChinaBackground: Limits of stability, defined as the ability to maintain the center of gravity within the boundary of the base of support, is critically important for older adults in performing their activities of daily living. However, few exercise programs specifically tailored to enhance limits of stability exist. The primary purpose of this study was to determine whether a therapeutically designed intervention, Tai Ji Quan: Moving for Better Balance (TJQMBB, could improve limits of stability in older adults. A secondary purpose was to examine concomitant change in limits of stability and physical performance as a result of the intervention.Methods: A single-group design was used in which 145 community-dwelling older adults (average age: 75 years were enrolled in TJQMBB classes, participating twice weekly for 48 weeks. Primary outcome measures were three indicators of limits of stability (LOS (endpoint excursion, movement velocity, and directional control, with secondary measures of physical performance being Timed Up and Go and 50-foot speed walk (in seconds, which were assessed at baseline, 24 weeks, and 48 weeks. Changes in the repeated measures of outcome variables were analyzed via latent curve analysis.Results: At 48 weeks, a significant rate of change (improvement over time was observed in the three limits of stability indicators (endpoint execution: 8.30% LOS, P<0.001; movement velocity: 0.86 degrees/second, P<0.001; directional control: 6.79% of 100, P<0.001; all reached a threshold of real change as judged by the minimal detectable change values. Improvements in the three limits of stability measures were concomitantly correlated with improved (reduced times performance scores in the Timed Up and Go (-0.30, -0.45, and -0.55, ­respectively and 50-foot walk (-0.33, -0.49, and -0.41, respectively

  4. Publisher Correction

    DEFF Research Database (Denmark)

    Turcot, Valérie; Lu, Yingchang; Highland, Heather M

    2018-01-01

    In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and E...

  5. The sustained-release behavior and in vitro and in vivo transfection of pEGFP-loaded core-shell-structured chitosan-based composite particles

    Directory of Open Access Journals (Sweden)

    Wang Y

    2014-10-01

    Full Text Available Yun Wang,1 Fu-xing Lin,2 Yu Zhao,1 Mo-zhen Wang,2 Xue-wu Ge,2 Zheng-xing Gong,1 Dan-dan Bao,1 Yu-fang Gu1 1Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, 2CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China Abstract: Novel submicron core-shell-structured chitosan-based composite particles ­encapsulated with enhanced green fluorescent protein plasmids (pEGFP were prepared by complex coacervation method. The core was pEGFP-loaded thiolated N-alkylated chitosan (TACS and the shell was pH- and temperature-responsive hydroxybutyl chitosan (HBC. pEGFP-loaded TACS-HBC composite particles were spherical, and had a mean diameter of approximately 120 nm, as measured by transmission electron microscopy and particle size analyzer. pEGFP showed sustained release in vitro for >15 days. Furthermore, in vitro transfection in human embryonic kidney 293T and human cervix epithelial cells, and in vivo transfection in mice skeletal muscle of loaded pEGFP, were investigated. Results showed that the expression of loaded pEGFP, both in vitro and in vivo, was slow but could be sustained over a long period. pEGFP expression in mice skeletal muscle was sustained for >60 days. This work indicates that these submicron core-shell-structured chitosan-based composite particles could potentially be used as a gene vector for in vivo controlled gene transfection. Keywords: gene therapy, gene transfection, hydroxybutyl chitosan, thiolated N-alkylated chitosan, pEGFP, complex coacervation

  6. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line

    Directory of Open Access Journals (Sweden)

    Zhen Zhang

    2010-10-01

    Full Text Available Zhen Zhang, Xiumei Zhang, Wei Xue, Yuna YangYang, Derong Xu, Yunxue Zhao, Haiyan LouSchool of Medicine, Shandong University, Jinan, Republic of ChinaAbstract: This study aims to investigate the inhibitory effects of oridonin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. The PC-3 cells were incubated with increasing concentrations of oridonin solution and nanosuspensions for 12 hours, 24 hours, and 36 hours. MTT [3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide] assay was performed to measure cellular viability and investigate the effect of oridonin on cell growth of PC-3. Annexin V-FITC/PI staining method was used to determine the effect of oridonin by fluorescence microscope and flow cytometry, respectively. Nanosuspension on early apoptosis of PC-3 cells was also evaluated. Oridonin significantly inhibited the growth of PC-3 cells after 12 hours, 24 hours, and 36 hours of treatment in a dose-dependent manner (P < 0.05. Compared with the same concentration of oridonin solution, oridonin nanosuspension enhanced the inhibition ratio of proliferation. The observation of propidium iodide fluorescence staining confirmed the MTT assay results. The cell proportion of PC-3 at the G2/M phase in the nanosuspension treatment group was upregulated compared with that of the control and oridonin solution groups. Both oridonin solution and nanosuspension promoted the early apoptosis of PC-3 cells. Furthermore, while improving the ratio of early apoptosis, oridonin nanosuspensions also enhanced growth suppression, and induced apoptosis of PC-3 cells. This shows great potential in the treatment of androgen-independent carcinoma of prostate by oridonin nanosuspensions.Keywords: oridonin, nanosuspension, carcinoma of prostate, PC-3 cells, cell cycle, apoptosis

  7. Understanding and Controlling Living/Inorganic Interfaces to Enable Reconfigurable Switchable Materials

    Science.gov (United States)

    2018-03-01

    Mater Res. 2015;4:297–310. Invited. Dong H, Sarkes DA, Rice JJ , Hurley MM, Fu A, Stratis-Cullum D. Functionalization of living bacterial cells with...presentation. Dong H, Sarkes DA, Rice JJ , Hurley MM, Fu A, Stratis-Cullum D. Living composites: Viable bacteria-nanoparticle hybrids mediated through...surface- displayed peptides. Langmuir. Forthcoming 2017. Dong H, Sarkes DA, Rice JJ , Hurley MM, Fu A, Stratis-Cullum DN. Living bacteria/nanoparticle

  8. Polarizing Ytterbium-Doped all-Solid Photonic Bandgap Fiber with 1150 micrometers2 Effective Mode Area

    Science.gov (United States)

    2015-02-11

    RESPONSIBLE PERSON 19b. TELEPHONE NUMBER Liang Dong Fanting Kong,, Guancheng Gu,, Thomas W. Hawkins ,, Joshua Parsons, Maxwell Jones,, Christopher...Dunn,, Monica T. Kalichevsky-Dong,, Benjamin Pulford,, Iyad Dajani,, Kunimasa Saitoh,, Stephen P. Palese,, Eric Cheung,, Liang Dong c. THIS PAGE The...ytterbium-doped all-solid photonic bandgap fiber with ~1150µm2 effective mode area Fanting Kong,1,* Guancheng Gu,1 Thomas W. Hawkins ,1 Joshua Parsons

  9. Fractionation of yeast extract by nanofiltration process to assess key compounds involved in CHO cell culture improvement.

    Science.gov (United States)

    Mosser, Mathilde; Kapel, Romain; Chevalot, Isabelle; Olmos, Eric; Marc, Ivan; Marc, Annie; Oriol, Eric

    2015-01-01

    Yeast extract (YE) is known to greatly enhance mammalian cell culture performances, but its undefined composition decreases process reliability. Accordingly, in the present study, the nature of YE compounds involved in the improvement of recombinant CHO cell growth and IgG production was investigated. First, the benefits of YE were verified, revealing that it increased maximal concentrations of viable cells and IgG up to 73 and 60%, respectively compared to a reference culture. Then, the analyses of YE composition highlighted the presence of molecules such as amino acids, vitamins, salts, nucleobase, and glucose that were contained in reference medium, while others including peptides, trehalose, polysaccharides, and nucleic acids were not. Consequently, YE was fractionated by a nanofiltration process to deeper evaluate its effects on CHO cell cultures. The YE molecules already contained in reference medium were mainly isolated in the permeate fraction together with trehalose and short peptides, while other molecules were concentrated in the retentate. Permeate, which was free of macromolecules, exhibited a similar positive effect than raw YE on maximal concentrations. Additional studies on cell energetic metabolism underlined that dipeptides and tripeptides in permeate were used as an efficient source of nitrogenous substrates. © 2015 American Institute of Chemical Engineers.

  10. Leaf curl diseases of two solanaceous species in Southwest Arabia are caused by a monopartite begomovirus evolutionarily most closely related to a species from the Nile Basin and unique suite of betasatellites

    KAUST Repository

    Idris, Ali

    2012-10-01

    The complete genome of 2780 bases was amplified using rolling circle amplification, and cloned, and sequenced for two distinct strains of the monopartite begomovirus Tomato leaf curl Sudan virus (ToLCSDV). The two strains shared 86-91% identity with the previously described ToLCSDV from the Nile Basin, and 90-91% identity with one another. One strain was cloned from symptomatic tomato plants from Tihamah (ToLCSDV-YE[YE:Tih:05]) while the other was cloned from symptomatic tobacco plants collected from Wadi Hadramaut (ToLCSDV-YE[YE:Had:89]). A distinct full-length betasatellite molecule (1352 bases) was cloned from the respective field-infected tomato and tobacco plants. Agro-inoculation of tomato and Nicotiana benthamiana plants with cloned partial tandem repeats of ToLCSDV-YE[YE:Tih11:05]) and the associated betasatellite, Tomato leaf curl Yemen betasatellite (ToLCYEB-[Tih:tom:137:05]), resulted in the reproduction of leaf curl disease symptoms in test plants like those observed in the field-infected plants. The betasatellite contributed to symptom severity in N. benthamiana test plants when it was co-inoculated with ToLCSDV-YE, compared to the milder symptoms that were observed in tobacco plants infected with the helper virus alone. © 2012 Elsevier B.V.

  11. Leaf curl diseases of two solanaceous species in Southwest Arabia are caused by a monopartite begomovirus evolutionarily most closely related to a species from the Nile Basin and unique suite of betasatellites

    KAUST Repository

    Idris, Ali; Abdullah, N.; Brown, Judith K.

    2012-01-01

    The complete genome of 2780 bases was amplified using rolling circle amplification, and cloned, and sequenced for two distinct strains of the monopartite begomovirus Tomato leaf curl Sudan virus (ToLCSDV). The two strains shared 86-91% identity with the previously described ToLCSDV from the Nile Basin, and 90-91% identity with one another. One strain was cloned from symptomatic tomato plants from Tihamah (ToLCSDV-YE[YE:Tih:05]) while the other was cloned from symptomatic tobacco plants collected from Wadi Hadramaut (ToLCSDV-YE[YE:Had:89]). A distinct full-length betasatellite molecule (1352 bases) was cloned from the respective field-infected tomato and tobacco plants. Agro-inoculation of tomato and Nicotiana benthamiana plants with cloned partial tandem repeats of ToLCSDV-YE[YE:Tih11:05]) and the associated betasatellite, Tomato leaf curl Yemen betasatellite (ToLCYEB-[Tih:tom:137:05]), resulted in the reproduction of leaf curl disease symptoms in test plants like those observed in the field-infected plants. The betasatellite contributed to symptom severity in N. benthamiana test plants when it was co-inoculated with ToLCSDV-YE, compared to the milder symptoms that were observed in tobacco plants infected with the helper virus alone. © 2012 Elsevier B.V.

  12. The potential role of B-function gene involved in floral development ...

    African Journals Online (AJOL)

    Camellia changii Ye, a rare and endangered species, has a phenotype that sepals frequently transform into petals. We assumed that this change would cause single C. changii Ye turned double flowers and this was confirmed by the double flowers we found in grafted C. changii Ye. The microstructure of floral organs ...

  13. 11

    African Journals Online (AJOL)

    a routine working week. Special ... day of the working week and retested after finishing work on ... 4. 3. Med. 11,8. 12. -ye. 0. 5. 5. Med. 27,3. 107. -ye. 2. 6. 6. Med. 17,1. 80. -Ye. 0. 7. 3 .... present hours after first exposure (e.g. at night), it is also.

  14. Joint Implementation under the UN Framework Convention on Climate Change. Technical and institutional challenges

    International Nuclear Information System (INIS)

    Swisher, J.N.

    1997-01-01

    The UN Framework Convention of Climate Change (FCCC) allows for the Joint Implementation (JI) of measures to mitigate the emissions of greenhouse gases. The concept of JI refers to the implementation of such measures in one country with partial and/or technical support from another country, potentially fulfilling some of the supporting country's emission-reduction commitment under the FCCC. At present, all JI transactions are voluntary, and no country has claimed JI credit against existing FCCC commitments. Nevertheless, JI could have important implications for both the economic efficiency and the international equity of the implementation of the FCCC. The paper discusses some of the information needs of JI projects and seeks to clarify some of the common assumptions and arguments about JI. Issues regarding JI are distinguished according to those that are specific to JI as well as other types of regimes and transactions. The focus is on the position of developing countries and their potential risks and benefits regarding JI. 2 figs., 3 tabs., 35 refs

  15. Thermophilic biofiltration of benzene and toluene.

    Science.gov (United States)

    Cho, Kyung-Suk; Yoo, Sun-Kyung; Ryu, Hee Wook

    2007-12-01

    In the current studies, we characterized the degradation of a hot mixture of benzene and toluene (BT) gases by a thermophilic biofilter using polyurethane as packing material and high-temperature compost as a microbial source. We also examined the effect of supplementing the biofilter with yeast extract (YE). We found that YE substantially enhanced microbial activity in the thermophilic biofilter. The degrading activity of the biofilter supplied with YE was stable during long-term operation (approximately 100 d) without accumulating excess biomass. The maximum elimination capacity (1,650 g x m(-3) h(-1)) in the biofilter supplemented with YE was 3.5 times higher than that in the biofilter without YE (470 g g x m(-3) h(-1)). At similar retention times, the capacity to eliminate BT for the YE-supplemented biofilter was higher than for previously reported mesophilic biofilters. Thus, thermophilic biofiltration can be used to degrade hydrophobic compounds such as a BT mixture. Finally, 16S rDNA polymerase chain reaction-DGGE (PCR-DGGE) fingerprinting revealed that the thermophilic bacteria in the biofilter included Rubrobacter sp. and Mycobacterium sp.

  16. Enhanced coal-dependent methanogenesis coupled with algal biofuels: Potential water recycle and carbon capture

    Science.gov (United States)

    Barnhart, Elliott P.; Davis, Katherine J.; Varonka, Matthew; Orem, William H.; Cunningham, Alfred B.; Ramsay, Bradley D.; Fields, Matthew W.

    2017-01-01

    Many coal beds contain microbial communities that can convert coal to natural gas (coalbed methane). Native microorganisms were obtained from Powder River Basin (PRB) coal seams with a diffusive microbial sampler placed downhole and used as an inoculum for enrichments with different nutrients to investigate microbially-enhanced coalbed methane production (MECoM). Coal-dependent methanogenesis more than doubled when yeast extract (YE) and several less complex components (proteins and amino acids) were added to the laboratory microcosms. Stimulated coal-dependent methanogenesis with peptone was 86% of that with YE while glutamate-stimulated activity was 65% of that with YE, and a vitamin mix had only 33% of the YE stimulated activity. For field application of MECoM, there is interest in identifying cost-effective alternatives to YE and other expensive nutrients. In laboratory studies, adding algal extract (AE) with lipids removed stimulated coal-dependent methanogenesis and the activity was 60% of that with YE at 27 d and almost 90% of YE activity at 1406 d. Analysis of British Thermal Unit (BTU) content of coal (a measure of potential energy yield) from long-term incubations indicated > 99.5% of BTU content remained after coalbed methane (CBM) stimulation with either AE or YE. Thus, the coal resource remains largely unchanged following stimulated microbial methane production. Algal CBM stimulation could lead to technologies that utilize coupled biological systems (photosynthesis and methane production) that sustainably enhance CBM production and generate algal biofuels while also sequestering carbon dioxide (CO2).

  17. [Stimuli phrases of adductor spasmodic dysphonia phonatory break in mandarin Chinese].

    Science.gov (United States)

    Ge, Pingjiang; Ren, Qingyi; Chen, Zhipeng; Cheng, Qiuhui; Sheng, Xiaoli; Wang, Ling; Chen, Shaohua; Zhang, Siyi

    2015-12-01

    To investigate the characteristics of adductor spasmodic dysphonia phonatory break in mandarin Chinese and select the stimuli phrases. Thirty-eight patients with adductor spasmodic dysphonia were involved in this study. Standard phrase " fù mŭ xīn" and a speech corpus in mandarin Chinese with 229 syllables covering all vowel and constant of mandarin Chinese were selected. Every patient read the phrases above twice in normal speed and comfortable voice. Two auditory perpetual speech pathologists marked phonatory break syllables respectively. The frequency of phonatory break syllables and their located phrases were calculated, rated and described. The phrases including the most phonatory break syllables were selected as stimuli phrases, the phonatory break frequency of which was also higher than that of standard phrase "fù mŭ xīn". Phonatory break happened in the reading of all patients. The average number of phonatory break syllables was 14 (3-33). Phonatroy break occurred when saying 177 (77.3%) syllables in the speech corpus. The syllables "guŏ, rén, zāng, diàn, chē, gè, guăn, a, bā, ne, de" broke in 23.1%-41.0% patients. These syllables belonged to the phrases "pĭng guŏ, huŏ chē, shì de, nĭ shì gè hăo rén, wŏ mén shì yŏu zŏng shì bă qĭn shì nong dé hĕn zāng, wŏ mén nà biān yŏu wăng qiú yùn dong chăng, cān gŭan, jiŭ bā hé yī gè miàn bāo dìan, tā shì duō me kāng kăi a,wŏ yīng gāi zài xìn lĭ xiĕ yī xiē shén mē ne?". Thirty-seven patients (97.3%) had phonatory break in above mentioned words. Ratios of these words phonatory break also were more than "fù mŭ xīn". Adductor spasmodic dysphonic patients exhibited different degrees of phonatory break in mandarine Chinese. The phrases" shì de, pĭng guŏ, huŏ chē, nĭ shì gè hăo rén, wŏ mén nà biān yŏu wăng qiú yùn dong chăng, cān gŭan, jiŭ bā hé yī gè miàn bāo dìan, tā shì duō me kāng kăi a" were recommended as stimuli

  18. Teaching undergraduate biomechanics with Just-in-Time Teaching.

    Science.gov (United States)

    Riskowski, Jody L

    2015-06-01

    Biomechanics education is a vital component of kinesiology, sports medicine, and physical education, as well as for many biomedical engineering and bioengineering undergraduate programmes. Little research exists regarding effective teaching strategies for biomechanics. However, prior work suggests that student learning in undergraduate physics courses has been aided by using the Just-in-Time Teaching (JiTT). As physics understanding plays a role in biomechanics understanding, the purpose of study was to evaluate the use of a JiTT framework in an undergraduate biomechanics course. This two-year action-based research study evaluated three JiTT frameworks: (1) no JiTT; (2) mathematics-based JiTT; and (3) concept-based JiTT. A pre- and post-course assessment of student learning used the biomechanics concept inventory and a biomechanics concept map. A general linear model assessed differences between the course assessments by JiTT framework in order to evaluate learning and teaching effectiveness. The results indicated significantly higher learning gains and better conceptual understanding in a concept-based JiTT course, relative to a mathematics-based JiTT or no JiTT course structure. These results suggest that a course structure involving concept-based questions using a JiTT strategy may be an effective method for engaging undergraduate students and promoting learning in biomechanics courses.

  19. Role of IFN-gamma and IL-6 in a protective immune response to Yersinia enterocolitica in mice

    Directory of Open Access Journals (Sweden)

    Autenrieth Ingo B

    2008-09-01

    Full Text Available Abstract Background Yersinia outer protein (Yop H is a secreted virulence factor of Yersinia enterocolitica (Ye, which inhibits phagocytosis of Ye and contributes to the virulence of Ye in mice. The aim of this study was to address whether and how YopH affects the innate immune response to Ye in mice. Results For this purpose, mice were infected with wild type Ye (pYV+ or a YopH-deficient Ye mutant strain (ΔyopH. CD11b+ cells were isolated from the infected spleen and subjected to gene expression analysis using microarrays. Despite the attenuation of ΔyopH in vivo, by variation of infection doses we were able to achieve conditions that allow comparison of gene expression in pYV+ and ΔyopH infection, using either comparable infection courses or splenic bacterial burden. Gene expression analysis provided evidence that expression levels of several immune response genes, including IFN-γ and IL-6, are high after pYV+ infection but low after sublethal ΔyopH infection. In line with these findings, infection of IFN-γR-/- and IL-6-/- mice with pYV+ or ΔyopH revealed that these cytokines are not necessarily required for control of ΔyopH, but are essential for defense against infection with the more virulent pYV+. Consistently, IFN-γ pretreatment of bone marrow derived macrophages (BMDM strongly enhanced their ability in killing intracellular Ye bacteria. Conclusion In conclusion, this data suggests that IFN-γ-mediated effector mechanisms can partially compensate virulence exerted by YopH. These results shed new light on the protective role of IFN-γ in Ye wild type infections.

  20. Art Theory or Political Philosophy?---Further Discussion on the Nature of Music Theory by Ji Kang%艺术理论抑或政治哲学?*--嵇康乐论的性质再探讨

    Institute of Scientific and Technical Information of China (English)

    杨杰

    2016-01-01

    学者多认为《声无哀乐论》是一篇艺术理论文献或者音乐美学文献,事实上它是一篇哲学文献。嵇康认为声音只有音阶节奏是否平和的体性,而没有哀乐的属性;哀乐是人的情感属性,平和的音乐只是宣导人本有的哀乐之情。他进一步认为音乐本身也没有德行、功用等“象”。他认为音乐是有教化作用的,首先要实行无为之政的良善政治,使得人心平和,产生平和之乐,二者相互涵养天下才会大治。与儒家以礼乐为主的乐教观不同,嵇康的乐教思想是以人心平和,从而实际上是以无为政治为首要目的的。因此嵇康的音乐理论最终指向的是乐教何以可能的政治哲学问题,《声论》是一篇政治哲学文献。%Most scholars regard No Funeral Music Theory as a literature about art theory or music aes‐thetics ,actually ,it is a literature about political philosophy .Ji Kang thinks that music only has the harmonious melody ,and has nothing to do with the human emotion related to political situation and other circumstances .The point is that grief and joy is the attribute of human emotion ,and the peace‐ful music only a tool to express this emotion .Furthermore ,he put forward that the music itself doesn't have the properties about virtue or function .He held the opinion that music had the function of in‐doctrination ,and we must carry out inaction in governance ,which drives everyone's emotion to a calm ,thus peaceful music being generated ,and the two sides promoting each other can eventually produce a well governed society .Different from Confucian view about music education ,Ji Kang regar‐ded inaction in governance is more important than music education .Therefore ,the finally aim of Ji kang's music theory is the possibility of music education ,which is a political problem ,as a conse‐quence ,No Funeral Music Theory is a literature about political philosophy .

  1. Autophagy promotes degradation of polyethyleneimine–alginate nanoparticles in endothelial progenitor cells

    Directory of Open Access Journals (Sweden)

    Wang GD

    2017-09-01

    Full Text Available Guo-dong Wang, Yu-zhen Tan, Hai-jie Wang, Pei Zhou Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai, China Abstract: Polyethyleneimine (PEI–alginate (Alg nanoparticle (NP is a safe and effective vector for delivery of siRNA or DNA. Recent studies suggest that autophagy is related to cytotoxicity of PEI NPs. However, contribution of autophagy to degradation of PEI–Alg NPs remains unknown. CD34+VEGFR-3+ endothelial progenitor cells isolated from rat bone marrow were treated with 25 kDa branched PEI modified by Alg. After treatment with the NPs, morphological changes and distribution of the NPs in the cells were examined with scanning and transmission electron microscopies. Cytotoxicity of the NPs was analyzed by reactive oxygen species (ROS production, lactate dehydrogenase leakage and induction of apoptosis. The level of autophagy was assessed with expression of Beclin-1 and LC3 and formation of autophagic structures and amphisomes. Colocalization of LC3-positive puncta and the NPs was determined by LC3–GFP tracing. Cytotoxicity of PEI NPs was reduced greatly after modification with Alg. PEI–Alg NPs were distributed in mitochondria, rough endoplasmic reticula and nuclei as well as cytoplasm. After phagocytosis of the NPs, expression of Beclin-1 mRNA and LC3 protein was upregulated, and the number of LC3-positive puncta, autophagic structures and amphisomes increased significantly. The number of lysosomes also increased obviously. There were LC3-positive puncta in nuclei, and some puncta were colocalized with the NPs. These results demonstrate that the activated autophagy promotes degradation of PEI–Alg NPs via multiple pathways. Keywords: polyethyleneimine, alginate, nanoparticles, endothelial progenitor cells, autophagy

  2. Role of green tea on nicotine toxicity on liver and lung of mice ...

    African Journals Online (AJOL)

    DR_Mohsen

    2012-01-26

    Jan 26, 2012 ... formation of lipid peroxidative products (Zhen et al.,. 2007). Antioxidant .... mg/kg green tea for three weeks showing normal lung structure with ..... injury in experimental model of carrageenan induced pleurisy in mice. Resp.

  3. Kanegelo ya Nimirode: Re lebelela diphihlelelo t�a gagwe ka lefsa

    Directory of Open Access Journals (Sweden)

    Elelwani B. Farisani

    2011-03-01

    Full Text Available Kanegelo ya Hama/Nimirode e �omi�it�we go gatelela Bathobaso ba Afrika-Borwa le ba Amerika. Taodi�wana ye e lekola Nimirode ka lefsa le go t�ea magato a go bu�et�a seriti sa gagwe le sa Bathobaso sekeng.Seo se tlo dirwa ka dikgato t�e tlhano ka mo tlase. Sa mathomo, re tlo lekola dimelo t�a bana ba Noage, go kwe�i�a Nimirode, yo e lego yena �edi ye kgolo ya taodi�wana ye. Sa bobedi re tlo lebelela ka fao bangwadi ba bangwe ba t�welet�ago seswant�ho sa go befa sa Nimirode. Sa boraro, re tlo sekaseka tiri�o ya kanegelo ya Hama/Nimirode go gatelela le go dira Bathobaso makgoba. Sa bone, re tlo sekaseka diphihlelelo le dikatlego t�a Nimirode. Mo re tlo tsepelela diphihlelelo t�a gagwe t�e tharo t�e kgolo bjalo ka go ba mmu�i wa maemo, motsomi yo maatla le moagi. Nepo ya karolo ye ke go ganet�ana le tshekatsheko ya go se be botse ye e nepilwego Nimirode nakong ya go feta. Re tlo tlalelet�a ka go fa tshekatsheko ye e tebilego ya thogako godimo ga Hama/Ku�e/Nimirode. Sa bohlano, ebile e le sa mafelelo, re tlo t�welet�a nyanyeng bohlokwa bja kanegelo ya Nimirode go bao ba bego ba gatelet�we le go ba makgoba ka baka la temana ye. Re tlo nepi�a Afrika-Borwa.

  4. Yeşilçam Döneminde Van’ın Sinema Kültürü Van’s Cinema Culture in Yeşilçam Period

    Directory of Open Access Journals (Sweden)

    Arzu ERTAYLAN

    2013-09-01

    Full Text Available The increase in the number of theoretical studies concerning cinema due to the increase in the number of communication and fine arts faculties has been a stubborn fact. Many academics and picturegoers have scrutinised the past and present Turkish cinema; many new and old films have been examined in terms of their subject matters, styles, ideologies, genres, directors or the representation of a specific subject; films have been analysed through certain research methods; and eventually, a theoretically significant literature has started to be created. The significance of these kinds of studies cannot be denied. Yet, it is evident that the number of field studies in Turkish cinema falls behind the pleasing increase in the number of theoretical studies. Although there are no requirements to equalise these numbers, it is believed that the significance of field studies should not be ignored.The field studies based on the data collected from a certain pilot region have the potential to provide practical answers for problems specific to this region. In this respect, the study titled “Van’s Cinema Culture in Yeşilçam Period” is considered significant. With this study, it is aimed to obtain data concerning the development of cinema in Van and also to contribute to the advancement of the field. Such a study necessitates research studies that would offer an insight to previous periods or at least official documents that have evidential value. However, the lack of sources materials has been an important problem during the study. This problem has forced the study to be based predicate mainly on interviews and a descriptive analysis. Therefore, the interviews with the owners of old movie theatres as well as the local people of Van who are famous for their interest in cinema and art have become prominent. The data obtained; is associated with the general socio-political and socio-cultural condition of Turkey in the same periods.In the first part, the

  5. Analysis of volatiles from irradiated yeast extract

    International Nuclear Information System (INIS)

    Liao Tao; Li Xin; Zu Xiaoyan; Chen Yuxia; Geng Shengrong

    2013-01-01

    The method for determination volatiles from irradiated yeast extract (YE) using headspace solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) was developed in this paper. The extraction conditions were optimized with reference to the peak area and number of volatiles as aldehyde, ketone, alcohol, acid, ester and sulfur compounds. The optimized conditions of HS-SPME for volatiles in irradiated YE were: divinyl benzene/Carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber, extration time 40 min, extraction temperature 40℃. The volatiles from YE irradiated by 0-19.8 kGy were detected using HS-SPME coupled with GC-MS. The results showed that only 15 volatiles were detected from no irradiated YE and main compounds were acetic acid, 2, 3-butanediol and 1-hexanol, 2-ethyl-. There were 40 volatiles detected from irradiated YE and the main compounds were acetic acid, phenylethyl alcohol, heptanal and nonanal. Compare to no irradiated yeast extract, the aldehyde, ketone, alkene and disulfide, dimethyl were produced by irradiating process. (authors)

  6. A de novo designed 11 kDa polypeptide: model for amyloidogenic intrinsically disordered proteins.

    Science.gov (United States)

    Topilina, Natalya I; Ermolenkov, Vladimir V; Sikirzhytski, Vitali; Higashiya, Seiichiro; Lednev, Igor K; Welch, John T

    2010-07-01

    A de novo polypeptide GH(6)[(GA)(3)GY(GA)(3)GE](8)GAH(6) (YE8) has a significant number of identical weakly interacting beta-strands with the turns and termini functionalized by charged amino acids to control polypeptide folding and aggregation. YE8 exists in a soluble, disordered form at neutral pH but is responsive to changes in pH and ionic strength. The evolution of YE8 secondary structure has been successfully quantified during all stages of polypeptide fibrillation by deep UV resonance Raman (DUVRR) spectroscopy combined with other morphological, structural, spectral, and tinctorial characterization. The YE8 folding kinetics at pH 3.5 are strongly dependent on polypeptide concentration with a lag phase that can be eliminated by seeding with a solution of folded fibrillar YE8. The lag phase of polypeptide folding is concentration dependent leading to the conclusion that beta-sheet folding of the 11-kDa amyloidogenic polypeptide is completely aggregation driven.

  7. Effect of progressive drought stress on growth, leaf gas exchange, and antioxidant production in two maize cultivars.

    Science.gov (United States)

    Anjum, Shakeel Ahmad; Tanveer, Mohsin; Ashraf, Umair; Hussain, Saddam; Shahzad, Babar; Khan, Imran; Wang, Longchang

    2016-09-01

    Drought stress is one of the major environmental factors responsible for reduction in crop productivity. In the present study, responses of two maize cultivars (Rung Nong 35 and Dong Dan 80) were examined to explicate the growth, yield, leaf gas exchange, leaf water contents, osmolyte accumulation, membrane lipid peroxidation, and antioxidant activity under progressive drought stress. Maize cultivars were subjected to varying field capacities (FC) viz., well-watered (80 % FC) and drought-stressed (35 % FC) at 45 days after sowing. The effects of drought stress were analyzed at 5, 10, 15, 20, ad 25 days after drought stress (DAS) imposition. Under prolonged drought stress, Rung Nong 35 exhibited higher reduction in growth and yield as compared to Dong Dan 80. Maize cultivar Dong Dan 80 showed higher leaf relative water content (RWC), free proline, and total carbohydrate accumulation than Run Nong 35. Malondialdehyde (MDA) and superoxide anion were increased with prolongation of drought stress, with higher rates in cultivar Run Nong 35 than cultivar Dong Dan 80. Higher production of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) and glutathione reductase (GR) resulted in improved growth and yield in Dong Dan 80. Overall, the cultivar Dong Dan 80 was better able to resist the detrimental effects of progressive drought stress as indicated by better growth and yield due to higher antioxidant enzymes, reduced lipid peroxidation, better accumulation of osmolytes, and maintenance of tissue water contents.

  8. Business perspectives on 'Joint Implementation': A study of conditions for Swedish company participation in Joint Implementation under the Kyoto Protocol; Foeretagsperspektiv paa 'Joint Implementation'. En studie av foerutsaettningar foer svenska foeretags deltagande i Gemensamt genomfoerande under Kyotoprotokollet

    Energy Technology Data Exchange (ETDEWEB)

    Burstroem von Malmborg, Fredrik [Royal Inst. of Tech., Stockholm (Sweden); Borgstroem, Truls; Dethlefsen, Ulrika; Kling, Aasa [Vattenfall AB, Stockholm (Sweden)

    2002-12-01

    At present, suggestions as for how a JI system would be designed and implemented are being worked out on a national level in Sweden and other countries. An important question in international and national climate policy and thus in work related to JI is how to engage companies. In order to make companies interested in investing and participating in JI, the mechanisms must be compatible with the ways in which companies work. Hence, knowledge and concern of conditions for those who are supposed to implement the politics in practice would be a key issue for the institutions that shape climate policy and JI systems. Given this background and the present situation regarding JI, this report aims at providing a business perspective on the prerequisites for implementing JI in Sweden. The main question addressed in the report is: What would make Swedish companies participate in JI projects? The study underlying this report covered three workshops where representatives of in all 15 Swedish companies from different industry sectors, by working in group, determined and discussed opportunities and obstacles for participation of companies in JI as well as concrete measures as for enabling such participation. From the empirical data collected we have found that Swedish companies, if not directly opposed to JI, play a waiting game at present regarding investments and participation in specific JI projects. According to the data, companies would invest and participate in JI projects if and only if it is found to be the most competitive of different alternatives for the company to meet its carbon dioxide emission restrictions or a profitable project. The former condition applies for companies with considerable CO{sub 2} emissions, the latter for companies with low or no such emissions. However, JI is currently perceived of as risky and associated with large uncertainties. The perceived uncertainties associated with JI participation are mainly related to indistinct and ambiguous

  9. In vitro and in vivo evaluation of SN-38 nanocrystals with different particle sizes

    Directory of Open Access Journals (Sweden)

    Chen M

    2017-08-01

    Full Text Available Min Chen,1,2 Wanqing Li,3 Xun Zhang,1 Ye Dong,1 Yabing Hua,1 Hui Zhang,1 Jing Gao,1 Liang Zhao,2 Ying Li,1 Aiping Zheng1 1State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 2School of Pharmacy, Jinzhou Medical University, Jinzhou, 3School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China Abstract: 7-Ethyl-10-hydroxycamptothecin (SN-38 is a potent broad-spectrum antitumor drug derived from irinotecan hydrochloride (CPT-11. Due to its poor solubility and instability of the active lactone ring, its clinical use is significantly limited. As one of the most promising formulations for poorly water-soluble drugs, nanocrystals have attracted increasing attention. In order to solve these problems and evaluate the antitumor effect of SN-38 in vitro and in vivo, two nanocrystals with markedly different particle sizes were prepared. Dynamic light scattering and transmission electron microscopy were used to investigate the two nanocrystals. The particle sizes of SN-38 nanocrystals A (SN-38/NCs-A and SN-38 nanocrystals B (SN-38/NCs-B were 229.5±1.99 and 799.2±14.44 nm, respectively. X-ray powder diffraction analysis showed that the crystalline state of SN-38 did not change in the size reduction process. An accelerated dissolution velocity of SN-38 was achieved by nanocrystals, and release rate of SN-38/NCs-A was significantly faster than that of SN-38/NCs-B. Cellular uptake, cellular cytotoxicity, pharmacokinetics, animal antitumor efficacy, and tissue distribution were subsequently examined. As a result, enhanced intracellular accumulation in HT1080 cells and cytotoxicity on different tumor cells were observed for SN-38/NCs-A compared to that for SN-38/NCs-B and solution. Besides, compared to the SN-38 solution, SN-38/NCs-A had a higher bioavailability after intravenous injection; while the bioavailability of SN-38/NCs-B was even lower than

  10. In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Gu MJ

    2015-08-01

    Full Text Available Meng-Jie Gu,1,* Kun-Feng Li,1,* Lan-Xin Zhang,1 Huan Wang,1 Li-Si Liu,2 Zhuo-Zhao Zheng,2 Nan-Yin Han,1 Zhen-Jun Yang,1 Tian-Yuan Fan1 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 2Department of Radiology, Peking University Third Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Novel gadolinium-loaded liposomes guided by GBI-10 aptamer were developed and evaluated in vitro to enhance magnetic resonance imaging (MRI diagnosis of tumor. Nontargeted gadolinium-loaded liposomes were achieved by incorporating amphipathic material, Gd (III [N,N-bis-stearylamidomethyl-N'-amidomethyl] diethylenetriamine tetraacetic acid, into the liposome membrane using lipid film hydration method. GBI-10, as the targeting ligand, was then conjugated onto the liposome surface to get GBI-10-targeted gadolinium-loaded liposomes (GTLs. Both nontargeted gadolinium-loaded liposomes and GTLs displayed good dispersion stability, optimal size, and zeta potential for tumor targeting, as well as favorable imaging properties with enhanced relaxivity compared with a commercial MRI contrast agent (CA, gadopentetate dimeglumine. The use of GBI-10 aptamer in this liposomal system was intended to result in increased accumulation of gadolinium at the periphery of C6 glioma cells, where the targeting extracellular matrix protein tenascin-C is overexpressed. Increased cellular binding of GTLs to C6 cells was confirmed by confocal microscopy, flow cytometry, and MRI, demonstrating the promise of this novel delivery system as a carrier of MRI contrast agent for the diagnosis of tumor. These studies provide a new strategy furthering the development of nanomedicine for both diagnosis and therapy of tumor. Keywords: magnetic resonance imaging, gadolinium, liposomes, tenascin-C, GBI-10 aptamer, tumor targeting

  11. Just-in-Time Teaching in undergraduate physics courses: Implementation, learning, and perceptions

    Science.gov (United States)

    Dwyer, Jessica Hewitt

    Regardless of discipline, a decades-long battle has ensued within nearly every classroom in higher education: instructors getting students to come to class prepared to learn. In response to this clash between teacher expectations and frequent student neglect, a group of four physics education researchers developed a reformed instructional strategy called Just-in-Time Teaching (JiTT). This dissertation investigates the following three areas: 1) the fidelity with which undergraduate physics instructors implement JiTT, 2) whether student performance predicts student perception of their instructor's fidelity of JiTT implementation, and 3) whether student perception of their instructor's fidelity of JiTT implementation correlates with student views of their physics course. A blend of quantitative data (e.g., students grades, inventory scores, and questionnaire responses) are integrated with qualitative data (e.g., individual faculty interviews, student focus group discussions, and classroom observations). This study revealed no statistically significant relationship between instructors who spent time on a predefined JiTT critical component and their designation as a JiTT user or non-user. While JiTT users implemented the pedagogy in accordance with the creators' intended ideal vision, many also had trouble reconciling personal concerns about their role as a JiTT adopter and the anticipated demand of the innovation. I recommend that this population of faculty members can serve as a JiTT model for other courses, disciplines, and/or institutions. Student performance was not a predictor of student perception instructor fidelity of JiTT implementation. Additionally, the majority of students in this study reported they read their textbook prior to class and that JiTT assignments helped them prepare for in-class learning. I found evidence that exposure to the JiTT strategy may correlate with a more favorable student view of their physics course. Finally, according to students

  12. Ushli v narod. Vernutsja li? / Irina Ljubarskaja

    Index Scriptorium Estoniae

    Ljubarskaja, Irina

    2000-01-01

    Vene filmifestivalilt "Kinotaurus". Lähemalt mängufilmidest "Kuu isaks" ("Lunnõi papa") : režissöör Bahtijer Hudoinazarov ja "Tema naise päevik" ("Dnevnik ego zhenõ") : režissöör Aleksei Utshitel

  13. Joint implementation in the climate change convention

    International Nuclear Information System (INIS)

    Merkus, H.; Heintz, R.

    1994-01-01

    The United Nations Climate Change Convention offers developed countries the possibility to realize a part of their obligations elsewhere via financing of emission reduction activities. This so-called joint implementation (JI) enlarges the effectiveness of the international climate change policy. It is assumed that the marginal costs of the emission reductions differ between countries. The application of JI has benefits, but also bears risks. With regard to potential nett benefits and costs/risks it is of interest to distinguish between micro-effects (on a project level), macro-effects (on a national level) and global effects, focusing on JI between OECD countries and developing countries. Five comments on this tripartite are made: (1) it is important to gain insight in the JI potential; (2) JI can contribute to projects of a high development priority; (3) there is a chance that parties, involved in JI, claim more reductions (credits) than take place in reality (double counting); (4) there exists the risk of a delay of technological progress; and (5) the danger exists that JI causes a minor stimulus for developing countries to accept emission reduction obligations. A functional JI-system demands criteria that limits the risks and optimize the benefits. The main criteria concern verification of realized emission reductions; an acceptable balance between measures in one's own country and JI, for which three mechanisms are briefly discussed (partial credit entry, funds, and separated targets); and additionality of JI-financing. Side criteria are the monitoring, verification and control of the possession of the credits. Finally attention is paid to the role of the government in JI and further developments and chances for JI. 7 refs

  14. Effect of Zhen Nao Capsules on Consolidated Disturbance of Memory Induced by NaNO2 in Mice%珍脑胶囊对NaNO2所致记忆巩固障碍小鼠学习记忆能力的影响

    Institute of Scientific and Technical Information of China (English)

    陈艳萍

    2009-01-01

    Objective To investigate the effects of Zhen Nao Capsules(ZN) on consolidated disturbance of memory in mice. Methods The memory deficits mice were induced by hypodermic injection of sodium nitrite(120mg·kg-1).Foraging maze and step-down tests were performed to evaluate the learning and memory of the deficits mice.Results ZN(2 000mg·kg-1 and 1 000 mg·kg-1) remarkably reduced the number of trials in labyrinth test and reduced the mistake times of step-down and prolonged step down latency in step-down tests. Conclusion It showed that ZN had a better improvement function on learning and memory in memory deficits mice.%目的 观察珍脑胶囊对亚硝酸钠(NaNO2)所致记忆巩固障碍小鼠学习记忆能力的影响.方法 采用皮下注射NaNO2制造记忆巩固障碍模型,通过迷宫试验和跳台试验,观察药物时模型小鼠学习记忆能力的影响.结果 珍脑胶囊可缩短迷宫试验中记忆巩固障碍小鼠的觅食时间;能够延长跳台试验中记忆巩固障碍小鼠的触电潜伏期,减少小鼠的错误次数.高、中剂量效果较好.结论 珍脑胶囊有改善学习记忆能力作用.

  15. Cost-effective electrostatic-sprayed SrAl2O4: Eu 2 phosphor ...

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Department of Biomedical Engineering, Nambu University, 864-1 Wolgye-dong, Gwangsan-gu, Gwangju 506-824, Korea; Department of Electronic and Photonic Engineering, Honam University, 59-1 Seobong-dong, Gwangsan-gu, Gwangju 506-714, Korea; Department of Photonic Engineering, Chosun ...

  16. African Journal of Biotechnology - Vol 10, No 37 (2011)

    African Journals Online (AJOL)

    7130 ... G Lu, Y Shen, W Qian, L Shen, Q Qiao, M Li, Z Wang, 7136-7142 ... LN Zhen, K Wang, YJ Zhang, H Zhou, 7161-7165 ... Effect of cadmium hyperaccumulation on antioxidative defense and proline accumulation of Solanum nigrumL.

  17. Abielu hiina tundmatuga / Allar Tankler

    Index Scriptorium Estoniae

    Tankler, Allar, 1981-

    2000-01-01

    Vt. ka Moldojozh Estonii : Subbota Mar/18 lk. 13. Messias Koreast, pastor Sun Myung Moon laulatas eesti mehe Peter Ljashevitshi ja hiinlanna Gui Zhen Yuani 1995. aastal Valgevenes, kus noorpaar nägi teineteist esimest korda elus Ühinemise liikumise massilaulatusel

  18. [Professor MA Ji-xing and Acupuncture Scientification at the Primary Stage of Establishment of the People's Republic of China].

    Science.gov (United States)

    Huo, Rui-li; Zhu, Ling; Yang, Feng

    2015-08-01

    In the initial stage (1950s) of the establishment of the People's Republic of China, the Pavlov's theory played an important influence on Chinese biology and medical science fields. At that time, many schools or colleges of traditional Chinese medicine were set up one after another, the first edition of teaching materials or textbook was complete, and a lot of advanced training courses and training classes were developed. In that specific period of "acupuncture scientification", Mr. MA Ji-xing, a professor from China Academy of Traditional Chinese Medicine, is a representative scholar who employed Pavlov's theory to make a scientific explanation about the underlying physiological mechanisms of acupuncture-moxibustion therapy. For example, he employed nerve network or nerve system to explain topical acupuncture stimulation and distal stimulation to induce local effect or distal curative effect, employed the cutaneous-visceral reflex to explain the therapeutic effect of acu-moxibustion for visceral disorders, used the viscera-cutaneous reflex to explain the tender point (sensitized region) or Ashi-point, used the "predominant factor mechanism" or excitation transfer of the stimulated non-sensitized cutaneous region close to the diseased locus to explain the pain-relief of acupuncture stimulation, used the stimulation strength, duration, frequency and distance (to the locus) to explain the needling reinforcing or reducing effect, and so on and so forth. He wrote many articles and books about acupuncturology, one of which was named Jianyao Zhenjiu Xue (Concise Acupuncturology), a well-known demonstration teaching material for advanced training courses, inducing a significant influence on the acu-moxibustion field in both academic field and clinical practice. Looking back this period of history may provide a helpful reference for current research on academic development of acupuncturology.

  19. Efeitos das mudanças do uso da terra na biogeoquímica dos corpos d'água da bacia do rio Ji-Paraná, Rondônia Effects of land use changes in the biogeochemistry of fluvial systems of the Ji-Paraná river basin, Rondônia

    Directory of Open Access Journals (Sweden)

    Alex Vladimir Krusche

    2005-06-01

    Full Text Available Este trabalho discute os efeitos das mudanças do uso do solo na biogequímica dos rios da bacia de drenagem do rio Ji-Paraná (Rondônia. Nesta região, a distribuição espacial do desmatamento e das propriedades do solo resultam em sinais diferentes, possibilitando a divisão dos sistemas fluviais em três grupos: rios com águas pobres em íons e baixo impacto; rios com conteúdo iônico intermediário e impacto médio e rios com elevados conteúdo iônico e impacto antropogênico. As características biogeoquímicas dos rios têm relação significativa com a área de pasto, melhor parâmetro para prever a condutividade elétrica (r² = 0,87 e as concentrações de sódio (r² = 0,75, cloreto (r² = 0,69, potássio (r² = 0,63, fosfato (r² = 0.78, nitrogênio inorgânico (r² = 0.52, carbono inorgânico (r² = 0.81 e carbono orgânico (rain ² = 0.51 dissolvidos. Cálcio e magnésio tiveram sua variância explicada pelas características do solo e pastagem. Nossos resultados indicam que as mudanças observadas na micro-escala constituem "sinais biogeoquímicos" gerados pelo processamento do material nas margens dos rios. A medida em que os rios evoluem para ordens superiores, os sinais persistentes nos canais fluviais estão mais associdados às características da bacia de drenagem (solos e uso da terra. Apesar dos efeitos das mudanças observadas no uso do solo não serem ainda detectáveis na macro-escala (bacia amazônica, a disrupção da estrutura e funcionamento dos ecossistemas é detectável nas micro e meso escalas, com alterações significativas na ciclagem de nutrientes nos ecossistemas fluviais.In this article we present the results of the effects of land use change on the river biogeochemistry of the Ji-Paraná basin (Rondônia. In this region, the spatial distribution of deforestation and soil properties result in different biogeochemical signals, allowing the division of the fluvial systems into three groups: rivers with

  20. Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction.

    Science.gov (United States)

    Mühlenkamp, Melanie C; Hallström, Teresia; Autenrieth, Ingo B; Bohn, Erwin; Linke, Dirk; Rinker, Janina; Riesbeck, Kristian; Singh, Birendra; Leo, Jack C; Hammerschmidt, Sven; Zipfel, Peter F; Schütz, Monika S

    2017-01-01

    Complement resistance is an important virulence trait of Yersinia enterocolitica (Ye). The predominant virulence factor expressed by Ye is Yersinia adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal complement complex by inhibiting the lytic pore formation. Here, we show YadA-mediated direct interaction of Ye with Vn and investigated the role of this Vn binding during mouse infection in vivo. Using different Yersinia strains, we identified a short stretch in the YadA head domain of Ye O:9 E40, similar to the 'uptake region' of Y. pseudotuberculosis YPIII YadA, as crucial for efficient Vn binding. Using recombinant fragments of Vn, we found the C-terminal part of Vn, including heparin-binding domain 3, to be responsible for binding to YadA. Moreover, we found that Vn bound to the bacterial surface is still functionally active and thus inhibits C5b-9 formation. In a mouse infection model, we demonstrate that Vn reduces complement-mediated killing of Ye O:9 E40 and, thus, improved bacterial survival. Taken together, these findings show that YadA-mediated Vn binding influences Ye pathogenesis. © 2016 S. Karger AG, Basel.

  1. A case-control study of Yersinia enterocolitica infections in Auckland.

    Science.gov (United States)

    Satterthwaite, P; Pritchard, K; Floyd, D; Law, B

    1999-10-01

    To identify major risk factors for Yersinia enterocolitica (YE) and identify measures to reduce YE infections. A prospective case control study, group age matched, using 186 cases of YE identified by community pathology laboratories and 379 randomly selected controls. Conducted between April 1995 and June 1996 in Auckland, New Zealand. Face-to-face interviews used a standardised questionnaire examining exposures to factors potentially associated with YE infections including untreated water, unreticulated sewerage, consumption of selected foods, selected food handling practices and socio-demographic factors. Multivariate logistic regression was used to calculate adjusted odds ratios for the potential risk factors. Population attributable risk (PAR) was calculated for significant exposures. Having more than two people living in the home was more common among cases than controls (OR = 2.2). Town supply water (OR = 0.2), reticulated sewerage (OR = 0.34) and looking after a young child (OR = 0.51) were significantly less common. Of the meats, only pork (OR = 1.34) had a higher consumption rate, while bacon (OR = 0.75) and smallgoods (OR = 0.73) were consumed less frequently by cases than controls. Eating food from a sandwich bar was more frequent among cases (OR = 1.18). Fruit and vegetable consumption was marginally less (OR = 0.98). The population attributable risk of these factors was 0.89, implying that 89% of YE would be eliminated if adverse exposures were removed. The risk of YE illness is increased by contact with untreated water, unreticulated sewerage and consumption of pork. Investigation of non-town water supply, informal sewerage systems and methods of preparation and consumption of pork are recommended to determine how YE enters the human food chain.

  2. QTL mapping for combining ability in different population-based ...

    Indian Academy of Sciences (India)

    based NCII designs: a simulation study. Lanzhi Li, Congwei Sun, Yuan Chen, Zhijun Dai, Zhen Qu, Xingfei Zheng, Sibin Yu,. Tongmin Mou, Chenwu Xu and Zhongli Hu. J. Genet. 92, 529–543. Journal of Genetics, Vol. 92, No. 3, December 2013 ...

  3. Using datamining approaches to selectacupoints in acupuncture ...

    African Journals Online (AJOL)

    Using datamining approaches to selectacupoints in acupuncture and Moxibustion for knee osteoarthritis. Changyan Liu, Youxin Su, Jian He, Yanan Li, Shaoqing Chen, Yingjie Zhang, Ziyi Zhang, Meili Lu, Zhen He, Wenting Wang, Yiru Wang, Lu Sheng, Zhengxuan Zhan, Xu Wang, Naixi Zheng ...

  4. Using just-in-time teaching and peer instruction in a residency program's core curriculum: enhancing satisfaction, engagement, and retention.

    Science.gov (United States)

    Schuller, Mary C; DaRosa, Debra A; Crandall, Marie L

    2015-03-01

    To assess use of the combined just-in-time teaching (JiTT) and peer instruction (PI) instructional strategy in a residency program's core curriculum. In 2010-2011, JiTT/PI was piloted in 31 core curriculum sessions taught by 22 faculty in the Northwestern University Feinberg School of Medicine's general surgery residency program. JiTT/PI required preliminary and categorical residents (n=31) to complete Web-based study questions before weekly specialty topic sessions. Responses were examined by faculty members "just in time" to tailor session content to residents' learning needs. In the sessions, residents answered multiple-choice questions (MCQs) using clickers and engaged in PI. Participants completed surveys assessing their perceptions of JiTT/PI. Videos were coded to assess resident engagement time in JiTT/PI sessions versus prior lecture-based sessions. Responses to topic session MCQs repeated in review sessions were evaluated to study retention. More than 70% of resident survey respondents indicated that JiTT/PI aided in the learning of key points. At least 90% of faculty survey respondents reported positive perceptions of aspects of the JiTT/PI strategy. Resident engagement time for JiTT/PI sessions was significantly greater than for prior lecture-based sessions (z=-2.4, P=.016). Significantly more review session MCQ responses were correct for residents who had attended corresponding JiTT/PI sessions than for residents who had not (chi-square=13.7; df=1; P<.001). JiTT/PI increased learner participation, learner retention, and the amount of learner-centered time. JiTT/PI represents an effective approach for meaningful and active learning in core curriculum sessions.

  5. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

    Science.gov (United States)

    Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P; Esko, Tõnu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L; Alfred, Tamuno; Feitosa, Mary F; Masca, Nicholas G D; Manning, Alisa K; Medina-Gomez, Carolina; Mudgal, Poorva; Ng, Maggie C Y; Reiner, Alex P; Vedantam, Sailaja; Willems, Sara M; Winkler, Thomas W; Abecasis, Gonçalo; Aben, Katja K; Alam, Dewan S; Alharthi, Sameer E; Allison, Matthew; Amouyel, Philippe; Asselbergs, Folkert W; Auer, Paul L; Balkau, Beverley; Bang, Lia E; Barroso, Inês; Bastarache, Lisa; Benn, Marianne; Bergmann, Sven; Bielak, Lawrence F; Blüher, Matthias; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; Böger, Carsten A; Bork-Jensen, Jette; Bots, Michiel L; Bottinger, Erwin P; Bowden, Donald W; Brandslund, Ivan; Breen, Gerome; Brilliant, Murray H; Broer, Linda; Brumat, Marco; Burt, Amber A; Butterworth, Adam S; Campbell, Peter T; Cappellani, Stefania; Carey, David J; Catamo, Eulalia; Caulfield, Mark J; Chambers, John C; Chasman, Daniel I; Chen, Yii-Der I; Chowdhury, Rajiv; Christensen, Cramer; Chu, Audrey Y; Cocca, Massimiliano; Collins, Francis S; Cook, James P; Corley, Janie; Corominas Galbany, Jordi; Cox, Amanda J; Crosslin, David S; Cuellar-Partida, Gabriel; D'Eustacchio, Angela; Danesh, John; Davies, Gail; Bakker, Paul I W; Groot, Mark C H; Mutsert, Renée; Deary, Ian J; Dedoussis, George; Demerath, Ellen W; Heijer, Martin; Hollander, Anneke I; Ruijter, Hester M; Dennis, Joe G; Denny, Josh C; Di Angelantonio, Emanuele; Drenos, Fotios; Du, Mengmeng; Dubé, Marie-Pierre; Dunning, Alison M; Easton, Douglas F; Edwards, Todd L; Ellinghaus, David; Ellinor, Patrick T; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-Eleni; Farooqi, I Sadaf; Faul, Jessica D; Fauser, Sascha; Feng, Shuang; Ferrannini, Ele; Ferrieres, Jean; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franco, Oscar H; Franke, Andre; Franks, Paul W; Friedrich, Nele; Frikke-Schmidt, Ruth; Galesloot, Tessel E; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Gibson, Jane; Giedraitis, Vilmantas; Gjesing, Anette P; Gordon-Larsen, Penny; Gorski, Mathias; Grabe, Hans-Jörgen; Grant, Struan F A; Grarup, Niels; Griffiths, Helen L; Grove, Megan L; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeff; Hakonarson, Hakon; Hammerschlag, Anke R; Hansen, Torben; Harris, Kathleen Mullan; Harris, Tamara B; Hattersley, Andrew T; Have, Christian T; Hayward, Caroline; He, Liang; Heard-Costa, Nancy L; Heath, Andrew C; Heid, Iris M; Helgeland, Øyvind; Hernesniemi, Jussi; Hewitt, Alex W; Holmen, Oddgeir L; Hovingh, G Kees; Howson, Joanna M M; Hu, Yao; Huang, Paul L; Huffman, Jennifer E; Ikram, M Arfan; Ingelsson, Erik; Jackson, Anne U; Jansson, Jan-Håkan; Jarvik, Gail P; Jensen, Gorm B; Jia, Yucheng; Johansson, Stefan; Jørgensen, Marit E; Jørgensen, Torben; Jukema, J Wouter; Kahali, Bratati; Kahn, René S; Kähönen, Mika; Kamstrup, Pia R; Kanoni, Stavroula; Kaprio, Jaakko; Karaleftheri, Maria; Kardia, Sharon L R; Karpe, Fredrik; Kathiresan, Sekar; Kee, Frank; Kiemeney, Lambertus A; Kim, Eric; Kitajima, Hidetoshi; Komulainen, Pirjo; Kooner, Jaspal S; Kooperberg, Charles; Korhonen, Tellervo; Kovacs, Peter; Kuivaniemi, Helena; Kutalik, Zoltán; Kuulasmaa, Kari; Kuusisto, Johanna; Laakso, Markku; Lakka, Timo A; Lamparter, David; Lange, Ethan M; Lange, Leslie A; Langenberg, Claudia; Larson, Eric B; Lee, Nanette R; Lehtimäki, Terho; Lewis, Cora E; Li, Huaixing; Li, Jin; Li-Gao, Ruifang; Lin, Honghuang; Lin, Keng-Hung; Lin, Li-An; Lin, Xu; Lind, Lars; Lindström, Jaana; Linneberg, Allan; Liu, Ching-Ti; Liu, Dajiang J; Liu, Yongmei; Lo, Ken S; Lophatananon, Artitaya; Lotery, Andrew J; Loukola, Anu; Luan, Jian'an; Lubitz, Steven A; Lyytikäinen, Leo-Pekka; Männistö, Satu; Marenne, Gaëlle; Mazul, Angela L; McCarthy, Mark I; McKean-Cowdin, Roberta; Medland, Sarah E; Meidtner, Karina; Milani, Lili; Mistry, Vanisha; Mitchell, Paul; Mohlke, Karen L; Moilanen, Leena; Moitry, Marie; Montgomery, Grant W; Mook-Kanamori, Dennis O; Moore, Carmel; Mori, Trevor A; Morris, Andrew D; Morris, Andrew P; Müller-Nurasyid, Martina; Munroe, Patricia B; Nalls, Mike A; Narisu, Narisu; Nelson, Christopher P; Neville, Matt; Nielsen, Sune F; Nikus, Kjell; Njølstad, Pål R; Nordestgaard, Børge G; Nyholt, Dale R; O'Connel, Jeffrey R; O'Donoghue, Michelle L; Olde Loohuis, Loes M; Ophoff, Roel A; Owen, Katharine R; Packard, Chris J; Padmanabhan, Sandosh; Palmer, Colin N A; Palmer, Nicholette D; Pasterkamp, Gerard; Patel, Aniruddh P; Pattie, Alison; Pedersen, Oluf; Peissig, Peggy L; Peloso, Gina M; Pennell, Craig E; Perola, Markus; Perry, James A; Perry, John R B; Pers, Tune H; Person, Thomas N; Peters, Annette; Petersen, Eva R B; Peyser, Patricia A; Pirie, Ailith; Polasek, Ozren; Polderman, Tinca J; Puolijoki, Hannu; Raitakari, Olli T; Rasheed, Asif; Rauramaa, Rainer; Reilly, Dermot F; Renström, Frida; Rheinberger, Myriam; Ridker, Paul M; Rioux, John D; Rivas, Manuel A; Roberts, David J; Robertson, Neil R; Robino, Antonietta; Rolandsson, Olov; Rudan, Igor; Ruth, Katherine S; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Sapkota, Yadav; Sattar, Naveed; Schoen, Robert E; Schreiner, Pamela J; Schulze, Matthias B; Scott, Robert A; Segura-Lepe, Marcelo P; Shah, Svati H; Sheu, Wayne H-H; Sim, Xueling; Slater, Andrew J; Small, Kerrin S; Smith, Albert V; Southam, Lorraine; Spector, Timothy D; Speliotes, Elizabeth K; Starr, John M; Stefansson, Kari; Steinthorsdottir, Valgerdur; Stirrups, Kathleen E; Strauch, Konstantin; Stringham, Heather M; Stumvoll, Michael; Sun, Liang; Surendran, Praveen; Swift, Amy J; Tada, Hayato; Tansey, Katherine E; Tardif, Jean-Claude; Taylor, Kent D; Teumer, Alexander; Thompson, Deborah J; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Thuesen, Betina H; Tönjes, Anke; Tromp, Gerard; Trompet, Stella; Tsafantakis, Emmanouil; Tuomilehto, Jaakko; Tybjaerg-Hansen, Anne; Tyrer, Jonathan P; Uher, Rudolf; Uitterlinden, André G; Uusitupa, Matti; Laan, Sander W; Duijn, Cornelia M; Leeuwen, Nienke; van Setten, Jessica; Vanhala, Mauno; Varbo, Anette; Varga, Tibor V; Varma, Rohit; Velez Edwards, Digna R; Vermeulen, Sita H; Veronesi, Giovanni; Vestergaard, Henrik; Vitart, Veronique; Vogt, Thomas F; Völker, Uwe; Vuckovic, Dragana; Wagenknecht, Lynne E; Walker, Mark; Wallentin, Lars; Wang, Feijie; Wang, Carol A; Wang, Shuai; Wang, Yiqin; Ware, Erin B; Wareham, Nicholas J; Warren, Helen R; Waterworth, Dawn M; Wessel, Jennifer; White, Harvey D; Willer, Cristen J; Wilson, James G; Witte, Daniel R; Wood, Andrew R; Wu, Ying; Yaghootkar, Hanieh; Yao, Jie; Yao, Pang; Yerges-Armstrong, Laura M; Young, Robin; Zeggini, Eleftheria; Zhan, Xiaowei; Zhang, Weihua; Zhao, Jing Hua; Zhao, Wei; Zhao, Wei; Zhou, Wei; Zondervan, Krina T; Rotter, Jerome I; Pospisilik, John A; Rivadeneira, Fernando; Borecki, Ingrid B; Deloukas, Panos; Frayling, Timothy M; Lettre, Guillaume; North, Kari E; Lindgren, Cecilia M; Hirschhorn, Joel N; Loos, Ruth J F

    2018-05-01

    In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

  6. The Role of Novel Substituted Diindolyl Methane Analogues in the Treatment of Triple-Negative and ErbB2-Positive Breast Cancer

    Science.gov (United States)

    2015-05-01

    factor and mediates vascular smooth muscle cell proliferation, J. Biol. Chem. 281 (2006) 33467–33476. [175] T. Nomiyama, Y. Zhao, F. Gizard, H.M. Findeisen ...vascular injury, Circulation 119 (2009) 577–586. [176] F. Gizard, Y. Zhao, H.M. Findeisen , H. Qing, D. Cohn, E.B. Heywood, K.L. Jones, T. Nomiyama, D...cell growth, Atherosclerosis 184 (2006) 276–282. [180] Y. Zhao, D.A. Howatt, F. Gizard, T. Nomiyama, H.M. Findeisen , E.B. Heywood, K. L. Jones, O.M

  7. Corrigendum: Childhood Adversity, Self-Esteem, and Diurnal Cortisol Profiles Across the Life Span.

    Science.gov (United States)

    2018-01-01

    Original article: Zilioli, S., Slatcher, R. B., Chi, P., Li, X., Zhao, J., & Zhao, G. (2016). Childhood adversity, self-esteem, and diurnal cortisol profiles across the life span. Psychological Science, 27, 1249-1265. doi:10.1177/0956797616658287.

  8. Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.

    Science.gov (United States)

    Du, Lifen; Lei, Yongfang; Chen, Jinglou; Song, Hongping; Wu, Xinying

    2017-01-01

    Cadmium (Cd) is an environmental pollutant with reproductive toxicity. Swertia mileensis is used in Chinese medicine for the treatment of prostatic deficits and named as Qing Ye Dan (QYD). This study was undertaken to investigate the potential protective effects of QYD against Cd-induced prostatic deficits. Rat model of prostatic deficits was induced by 0.2 mg/kg/d CdCl2 subcutaneous injection for 15 days. The prostatic oxidative stress was evaluated by detecting the levels of malondialdehyde, nitric oxide, reduced/ oxidized glutathione, total sulfhydryl groups and enzymatic antioxidant status. The prostatic inflammation was estimated by testing the levels of pro-inflammatory cytokines. The levels of epithelial-mesenchymal transition (EMT) markers E-cadherin, fibronectin, vimentin and α-smooth muscle actin were measured by qPCR analysis. Additionally, the prostatic expressions of transforming growth factor-β1 (TGF-β1), type I TGF-β receptor (TGF-βRI), Smad2, phosphorylation-Smad2 (p-Smad2), Smad3, p-Smad3, Smad7, nuclear related factor-2 (Nrf-2), heme oxygenase-1 (HO-1), B-cell CLL/lymphoma (Bcl)-2 and Bcl-2-associated X protein (Bax) were measured by western blot assay. It was found that QYD ameliorated the Cd-induced prostatic oxidative stress and inflammation, attenuated prostatic EMT, inhibited the TGF-β1/Smad pathway, increased Bcl-2/Bax ratio and enhanced the activity of Nrf-2/HO-1 pathway. These results showed that QYD could ameliorate Cd-induced prostatic deficits via modulating Nrf-2/HO-1 and TGF-β1/Smad pathways. © 2017 The Author(s). Published by S. Karger AG, Basel.

  9. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Dong Zhang. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 25-28. Aqueous colloids of graphene oxide nanosheets by exfoliation of graphite oxide without ultrasonication · Tian-You Zhang Dong Zhang · More Details Abstract Fulltext PDF.

  10. A computerized loop based approach for identification of ...

    Indian Academy of Sciences (India)

    A modified loop-joint approach is proposed in this work as compared to the previ- ..... capability of chain string, two 15 link (M = 4) kinematic chains (Marin et al 2007) .... Huafeng D and Zhen H 2007 A new theory for the topological structure ...

  11. A framework for the assessment of the global potential of joint implementation

    International Nuclear Information System (INIS)

    Bollen, J.C.; Van Minnen, J.G.; Toet, A.M.C.; Kuik, O.J.; Bennis, M.

    1995-09-01

    Joint Implementation (JI) is a means for reaching cheaper solutions to CO 2 -emission reductions. The global potential for JI is defined as the portion of the necessary regional CO 2 -emission reductions to meet the goals defined for a target year that can be more cost-effectively implemented in other regions. The goals will come from multilateral negotiations and may be the starting point of any bilateral negotiation process concerning JI-agreements. The more the goals will take cost-effectiveness criteria into account the less scope there will be for additional JI-agreements. In cases where the goals are stricter, the globally required emission reductions will be larger and consequently larger emission reductions could be be achieved in other regions. However, as compared to the other cases presented in the report the potential for JI will be lower, since the potential is defined as a fraction of the necessary global emission reduction. JI could reduce the total costs of CO 2 -emission reduction by more than 75% compared to the situation without JI, depending on the initial distribution of CO 2 -targets, the target year and the scenario-assumptions. For donor countries the cost reductions could be more than 50%, even when it is assumed that the subsidies for emission reduction measures in receptor countries are 50% higher than the actual costs. In donor countries the resulting domestic CO 2 -emission reductions after JI could be more than 50% less than the original goals before JI. In comparison to other OECD regions (Japan, Oceania, and the United States), Western Europe's gains from JI are less. In other words, in a world market for JI projects, Western Europe could face strong competition. 7 figs., 25 tabs., 37 refs., 1 appendix

  12. Study on the Correlation between Gene Expression and Enzyme Activity of Seven Key Enzymes and Ginsenoside Content in Ginseng in Over Time in Ji'an, China.

    Science.gov (United States)

    Yin, Juxin; Zhang, Daihui; Zhuang, Jianjian; Huang, Yi; Mu, Ying; Lv, Shaowu

    2017-12-11

    Panax ginseng is a traditional medicine. Fresh ginseng is one of the most important industries related to ginseng development, and fresh ginseng of varying ages has different medicinal properties. Previous research has not systematically reported the correlation between changes in key enzyme activity with changes in ginsenoside content in fresh ginseng over time. In this study, for the first time, we use ginseng samples of varying ages in Ji'an and systematically reported the changes in the activity of seven key enzymes (HMGR, FPS, SS, SE, DS, CYP450, and GT). We investigated the content of ginsenoside and gene expression of these key enzymes. Ginsenoside content was measured using HPLC. HPLC, GC-MS, and LC-MS were combined to measure the enzyme activity of the key enzymes. Quantitative PCR was used in the investigation of gene expression. By analyzing the correlation between the enzyme activity and the transcription level of the key enzymes with ginsenoside content, we found that DS and GT enzyme activities are significantly correlated with the ginsenoside content in different ages of ginseng. Our findings might provide a new strategy to discriminate between ginseng of different years. Meanwhile, this research provides important information for the in-depth study of ginsenoside biosynthesis.

  13. Sheng-ji Hua-yu formula promotes diabetic wound healing of re-epithelization via Activin/Follistatin regulation.

    Science.gov (United States)

    Kuai, Le; Zhang, Jing-Ting; Deng, Yu; Xu, Shun; Xu, Xun-Zhe; Wu, Min-Feng; Guo, Dong-Jie; Chen, Yu; Wu, Ren-Jie; Zhao, Xing-Qiang; Nian, Hua; Li, Bin; Li, Fu-Lun

    2018-01-29

    Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how the SJHY Formula affects excessive inflammation in the process of re-epithelialization of diabetic wound healing is a task urgently needed to be fulfilled. The objectives of this study is to evaluate the effect of antagonisic expression of pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin) in the process of re-epithelialization of diabetic wound healing in vivo, and to characterize the involvement of the activin/follistatin protein expression regulation, phospho-Smad (pSmad2), and Nuclear factor kappa B p50 (NF-kB) p50 in the diabetic wound healing effects of SJHY formula. SJHY Formula was prepared by pharmaceutical preparation room of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. Diabetic wound healing activity was evaluated by circular excision wound models. Wound healing activity was examined by macroscopic evaluation. Activin/follistatin expression regulation, protein expression of pSmad2 and NF-kB p50 in skin tissue of wounds were analyzed by Real Time PCR, Western blot, immunohistochemistry and hematoxylin and eosin (H&E) staining. Macroscopic evaluation analysis showed that wound healing of diabetic mice was delayed, and SJHY Formula accelerated wound healing time of diabetic mice. Real Time PCR analysis showed higher mRNA expression of activin/follistatin in diabetic delayed wound versus the wound in normal mice. Western Blot immunoassay analysis showed reduction of activin/follistatin proteins levels by SJHY Formula treatment 15 days after injury. Immunohistochemistry investigated the reduction of pSmad2 and NF-kB p50 nuclear staining in the epidermis of diabetic SJHY versus diabetic control mice on day 15 after wounding. H&E staining revealed that SJHY Formula

  14. Quotient functions of dual quermassintegrals | Zhao | Quaestiones ...

    African Journals Online (AJOL)

    Motivated by the notion of volume difference functions, we introduce quotient functions of dual quermassintegrals and establish Brunn-Minkowski type inequalities for them, which have several recent results as special cases. Keywords: Volume difference function, dual quermassintegrals, quotient function, radial Blaschke ...

  15. RELATIONSHIPS BETWEEN GENETIC POLYMORPHISM AND DRUG: FORENSIC PHARMACOGENETIC

    OpenAIRE

    Çevik, Filiz Ekim; Balcıoğlu, Yasin Hasan; Karadayı, Şükriye; Çakan, Hüseyin

    2015-01-01

    Filiz Ekim ÇEVİK1, Yasin Hasan BALCIOĞLU1, Şükriye KARADAYI2, Hüseyin ÇAKAN1 1İstanbul University, Forensic Medicine Institute, TÜRKİYE 2İstanbul University, Public Health Directorate, TÜRKİYE

  16. Marketing channel choice and marketing timing of peri-urban vegetable growers in Vietnam

    NARCIS (Netherlands)

    Wiersinga, R.C.; Wijk, van M.S.; Luyen, C.H.; Hoi, P.V.

    2007-01-01

    Agriculture is an important sector in the peri-urban area of Hanoi. It supplies 62 to 80% of vegetable consumption, of which 28% comes from Dong Anh district, which borders Hanoi City. Growing vegetables is an important income source for the farmers in Dong Anh as it contributes about 30% to their

  17. 論戴震 (1723–1777 之考證哲學及其反思/On Dai Zhen’s (1723–1777 Philosophy of Evidential Research and Its Reflection

    Directory of Open Access Journals (Sweden)

    Jer-shiarn LEE

    2012-09-01

    Dai Zhen was known as a leading proponent of the evidential research (kaozheng school during the Qian Jia Era. However, he regarded kaozheng as primarily a means of revealing the truth. Moreover, he was regarded as a philosopher rather than as merely a kaozheng, or textual, scholar. In this respect, his philosophical writings reflect an attempt to substitute his own philosophy for the Song Philosophy of Principle (lixue. Dai Zhen’s philosophical writings indicate the impact philology had on philosophical issues. The methodology Dai Zhen adopted was essentially linguistic, that is, xungu (etymology, lit., “glossing”. The merit of this methodology was that it would trace back the original meanings of key terms in the Classics, and this in turn, would benefit the understanding of the Confucian tradition. The aim of this paper is to explore Dai Zhen’s attempt to reconstruct the Confucian tradition, and to assess his philosophy of evidential research in order to manifest its value and limitation.

  18. 78 FR 41995 - Actions Taken Pursuant to Executive Order 13382

    Science.gov (United States)

    2013-07-12

    ...-hour fax-on-demand service, Tel.: 202/622-0077. Background On June 28, 2005, the President, invoking... Executive Order 13382. The list of additional designees is as follows: 1. DAEDONG CREDIT BANK (a.k.a. DAE-DONG CREDIT BANK; a.k.a. DCB; a.k.a. TAEDONG CREDIT BANK), Suite 401, Potonggang Hotel, Ansan-Dong...

  19. A Self-Adaptive Energy-Efficient Framework for Large Unattended Wireless Sensor Networks

    Science.gov (United States)

    2014-11-06

    Transactions on Vehicular Technology, (10 2011): 3919. doi: 10.1109/ TVT .2011.2166093 Miao Zhao, Yuanyuan Yang. Optimization-Based DistributedAlgorithms for...Networks, IEEE Transactions on Vehicular Technology, (05 2013): 0. doi: 10.1109/ TVT .2012.2229309 Miao Zhao, Ming Ma, Yuanyuan Yang. Applying

  20. Pitfalls in VAR based return decompositions: A clarification

    DEFF Research Database (Denmark)

    Engsted, Tom; Pedersen, Thomas Quistgaard; Tanggaard, Carsten

    in their analysis is not "cashflow news" but "inter- est rate news" which should not be zero. Consequently, in contrast to what Chen and Zhao claim, their decomposition does not serve as a valid caution against VAR based decompositions. Second, we point out that in order for VAR based decompositions to be valid......Based on Chen and Zhao's (2009) criticism of VAR based return de- compositions, we explain in detail the various limitations and pitfalls involved in such decompositions. First, we show that Chen and Zhao's interpretation of their excess bond return decomposition is wrong: the residual component...

  1. Wadi Ladid Al-JI,Dan Alkali Feldspar Granites and Associated Pegmatites, North Eastern Eser, Egypt:Geology,Mineralogy and Radioactivity

    International Nuclear Information System (INIS)

    Abu Steet, A.A.; Ayoub, R.R.; Bakhit, A.F.

    2013-01-01

    This article deals with the geology, structure, mineralogy and radioactivity of the alkali feldspar granites at wadi Ladid al-Ji,dan, north Eastern Desert of Egypt. Geologically, the area consists mainly of alkali feldspar granites. These granites are medium to coarse grained, pink to red in colour and form numbers of moderate to relatively high elevated outcrops. These rocks are altered in some parts due to secondary processes especially along the fault zones and contacts. The area displays primary and secondary structures. Primary structures comprise layering, volcanic flows, vesicular tops of lavas and volcanic bombs. The secondary structures are represented by exfoliation, joints and faults. The granites are dissected by several sets of joints predominating in the N-S direction, dipping 84°-88° mainly to west; E-W direction, dipping 70°-75° mainly to south and NW-SE direction, dipping 80°-82° to SW direction. The majority of joints are tension ones. These tension joints are commonly filled with quartz, feldspars, epidote, iron oxides, manganese oxides and aplite. The studied area is dissected by major regional faults. Along the fault zones; the granites are marked by fault breccia and alteration features, especially silicification, hematitization, kaolinitization and chloritization. The area is cutting by faults trending mainly in N-S, NE-SW and NNW-SSE directions. The average uranium and thorium contents of the alkali feldspar granites are 12 and 23 ppm and reaches up to 36 and 37 ppm in the normal pegmatites. In the anomalous pegmatites the maximum values recorded are 91 and 72 ppm. Generally, the averages of uranium and thorium contents in the studied pegmatites are higher than that of the world and Egyptian uraniferous pegmatites. The high uranium content in alkali feldspar granites is related to the presence of some accessory minerals such as zircon, fluorite and apatite but the high uranium content in the pegmatites is related to the presence of

  2. JI1II

    African Journals Online (AJOL)

    books, this one is based on a series of articles which origi- nally appeared in the ... Hospital Bone Bank at Harvard Medical School and has made a tremendous ... of Africa; and to the negative impact on the economy, due to direct and indirect ...

  3. Investigation of Possible Tsunami Events on the Eastern Coast of Taiwan: Case Studies of Lu-Ye, Changping, and Tulan.

    Science.gov (United States)

    Laksono, A. T., Jr.; Tsai, L. L. Y., Sr.

    2017-12-01

    Major earthquakes had occurred in eastern Taiwan for many times. According to an Amis folklore originated in Chengkong City, there was a big sea wave struck their settlement in 1850 AD. Several studies had been conducted, however, the evidence which indicates the tsunami was very weak. There is also a possibility that big sea waves had occurred due to typhoons which take place 3-4 times a year in Taiwan. The purpose of this study is to prove the possibility of tsunami events on the eastern coast of Taiwan based on sedimentological features. The methods in this study are facies analysis including observation of the marine terrace along Lu-Ye, Changping, and Tulan, identification of lithology, sedimentary structure, and fossil content. Lithology analysis is conducted by using point counting of 12 sandstone samples from marine terrace outcrops. Based on the field observation, we found a thin sand marine deposit included in the beach gravel at a height of 10 meters at the Changping marine terrace. It contains coral and some Mollusca shells and does not display any particular sedimentary structure. Sediments that have similar characteristics were also found in the Tulan marine terrace with a height of 5 m. In addition, fossil analysis of marine sand in Tulan exhibits the presence of several planktonic foraminifera fossils such as Orbulina bilobata and Globigerinoides ruber. Temporary interpretation indicates that there is a "super" event which transports shallow marine and beach materials subsequently deposit them on top of an alluvial fan. A 10 cm thin layer of sediment serves as an early tsunami indicator. In addition, the absence of deposits with the same characteristics further indicates that the event occurred only once. Since the eastern coast of Taiwan is an uplift zone with an uplift rate between 5-8 mm/year, the estimated wave height of tsunami should take into account both the tsunami age and the uplift rate. Furthermore, based on the distance from the

  4. How Do the Metabolic Effects of Chronic Stress Influence Breast Cancer Biology?

    Science.gov (United States)

    2012-04-01

    Paul A. Volden, Erin L. Wonder, Maxwell N. Skor, Christopher M. Carmean, Honggang Ye, Masha Kocherginsky, Eleanor Smith, Steven Kregel, Martha K...Wonder, Maxwell N. Skor, Christopher M. Carmean, Honggang Ye, Masha Kocherginsky, Steven Kregel, Martha K. McClintock, Matthew J. Brady, and Suzanne

  5. Prevalence, serotype, virulence characteristics, clonality and antibiotic susceptibility of pathogenic Yersinia enterocolitica from swine feces

    Science.gov (United States)

    Introduction: Swine are the only known animal reservoir of Yersinia enterocolitica (YE), a human pathogen. Since YE is a fecal organism of swine, the primary goal of this study was to evaluate the prevalence, serotype, virulence plasmid (pYV)-associated characteristics, clonality, and antibiotic su...

  6. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... You-Dong Hu. Articles written in Journal of Astrophysics and Astronomy. Volume 35 Issue 3 September 2014 pp 423-427 Part V: Black Holes (or Binary Black Holes) in Blazars. Joint Spectral Analysis for Early Bright X-ray Flares of -Ray Bursts with Swift BAT and XRT Data · Fang-Kun Peng You-Dong Hu ...

  7. Joint implementation demo project between Denmark and Estonia - Phase 1. Final report

    International Nuclear Information System (INIS)

    2003-09-01

    This project is meant to contribute to form the basis of co-operation between Denmark and Estonia as regards Joint Implementation (JI) and thus gather experience in preparation for practical use of JI. A number of questions can be raised for discussion within this project: What is the scope for JI? What is the role of the host country government? Will JI survive the emerging Emission Trading? The project report gives a status of the present situation within the area of JI both internationally and in Estonia, including a resume of the Estonian National Climate Programme. Furthermore, a stakeholder analysis is presented, along with an illustration of the effect of Joint Implementation in the various energy sectors. (BA)

  8. Effects of traditional Chinese medicine on rats with Type II diabetes ...

    African Journals Online (AJOL)

    Effects of traditional Chinese medicine on rats with Type II diabetes induced by high-fat diet and streptozotocin: A urine metabonomic study. H Zhao, Z Li, G Tian, K Gao, Li Zhiyong, B Zhao, J Wang, L Luo, Q Pan, W Zhang, Z Wu, J Chen, W Wang ...

  9. Breviscapine suppresses the growth of non-small cell lung cancer ...

    Indian Academy of Sciences (India)

    2017-02-10

    Feb 10, 2017 ... 2016), miR-21 (Zhao et al. 2015b),. miR-34a (Zhao et al. 2015c) and miR-7 (He et al. 2015), act as oncogenes or tumour suppressors that affect cancer ... hai Rong He Bioengineering Company, China), the cells. (96-well ...

  10. Detection of Yersinia enterocolitica serotype O:9 in the faeces of cattle with false positive reactions in serological tests for brucellosis in Ireland.

    Science.gov (United States)

    O'Grady, Don; Kenny, Kevin; Power, Seamus; Egan, John; Ryan, Fergus

    2016-10-01

    Intestinal infection by Yersinia enterocolitica serotype O:9 (YeO9) in cattle has been linked to false positive serological reactivity (FPSR) in diagnostic tests for brucellosis. Although eradicated in Ireland, brucellosis monitoring still identifies seropositive animals, usually one or two (termed singletons) per herd, which are classed as FPSR. To investigate a link between FPSR and YeO9, faeces and blood were collected from singleton FPSR cattle, and from companion animals, in eight selected herds with more than one FPSR animal, for YeO9 culture and Brucella serology. YeO9 was isolated from 76/474 (16%) FPSR singletons in 309 herds, but not from any of 621 animals in 122 control non-FPSR herds. In the FPSR herds 52/187 (27.8%) animals were culture positive, and 17% of the isolates were from seronegative animals. Seropositive animals were more likely to have a rising antibody titre when culture positive. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 122; Issue 6. Synthesis and aggregation study of optically active tetra--[()-2-octanyloxy]-substituted copper and nickel phthalocyanines. Fang-Di Cong Gui Gao Jian-Xin Li Guo-Qing Huang Zhen Wei Feng-Yang Yu Xi-Guang Du Ke-Zhi Xing. Full Papers Volume ...

  12. Author Details

    African Journals Online (AJOL)

    He, Zhen. Vol 13, No 2 (2016) - Articles Using datamining approaches to selectacupoints in acupuncture and Moxibustion for knee osteoarthritis. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

  13. Production of succinic acid from sugarcane molasses supplemented with a mixture of corn steep liquor powder and peanut meal as nitrogen sources by Actinobacillus succinogenes.

    Science.gov (United States)

    Shen, N; Qin, Y; Wang, Q; Liao, S; Zhu, J; Zhu, Q; Mi, H; Adhikari, B; Wei, Y; Huang, R

    2015-06-01

    The potential of using corn steep liquor powder (CSLP), peanut meal (PM), soybean meal (SM), cotton meal (CM) and urea as the substitute of yeast extract (YE) as the nitrogen source was investigated for producing succinic acid (SA). Actinobacillus succinogenes GXAS137 was used as the fermenting bacterium and sugarcane molasses was used as the main substrate. None of these materials were able to produce SA as high as YE did. The CSLP could still be considered as a feasible and inexpensive alternate for YE as the yield of SA produced using CSLP was second only to the yield of SA obtained by YE. The use of CSLP-PM mixed formulation (CSLP to PM ratio = 2·6) as nitrogen source produced SA up to 59·2 g l(-1) with a productivity of 1·2 g l(-1) h(-1). A batch fermentation using a stirred bioreactor produced up to 60·7 g l(-1) of SA at the same formulation. Fed-batch fermentation that minimized the substrate inhibition produced 64·7 g l(-1) SA. These results suggest that sugarcane molasses supplemented with a mixture of CSLP and PM as the nitrogen source could be used to produce SA more economically using A. succinogenes. Significance and impact of the study: Succinic acid (SA) is commonly used as a platform chemical to produce a number of high value derivatives. Yeast extract (YE) is used as a nitrogen source to produce SA. The high cost of YE is currently the limiting factor for industrial production of SA. This study reports the use of a mixture of corn steep liquor powder (CSLP) and peanut meal (PM) as an inexpensive nitrogen source to substitute YE. The results showed that this CSLP-PM mixed formulation can be used as an effective and economic nitrogen source for the production of SA. © 2015 The Society for Applied Microbiology.

  14. [Raamat] / Elisa Loopealne

    Index Scriptorium Estoniae

    Loopealne, Elisa

    2007-01-01

    Tutvustus: Bristol, Piret. Nöörist ja seebist. Pärnu : Jumalikud Ilmutused, 2006. (Ji) ; Kivisildnik. Vägistatud jäämägi. Pärnu : Jumalikud Ilmutused, 2006. (Ji) ; Sild, Ivar. Spermaga ja puha. Pärnu : Jumalikud Ilmutused, 2006. (Ji) ; Meiel, Kaupo. Polügrafisti käsiraamat, 2006

  15. glim ti signifi n e of hGr nd IQgGIPg r tios in srish o k ellulose

    Indian Academy of Sciences (India)

    long hronology were rried outD overing period of IPQ ye rs @IVTIEEIWVQ eFhFA with S ye r resolution so s to ... developedF pirstlyD the ristle one pine @ inus rist t nd inus long ... dust into the str tosphere nd onsequently ools the. tmosphereD ...

  16. Browse Title Index

    African Journals Online (AJOL)

    Items 4451 - 4500 of 11090 ... Lingling Zhao, Jinping Wu, Ying Diao, Zhongli Hu. Vol 10, No 39 (2011), Embryogenesis of Gentiana straminea and assessment of genetic stability of regenerated plants using inter simple sequence repeat (ISSR) marker, Abstract PDF. T He, L Yang, Z Zhao. Vol 10, No 45 (2011), Emergence and ...

  17. A reviewof the pharmacologicalmechanism of traditional Chinese ...

    African Journals Online (AJOL)

    A reviewof the pharmacologicalmechanism of traditional Chinese medicine in the intervention of coronary heart disease and stroke. W Zhang, K Gao, K Gao, J Liu, J Liu, H Zhao, H Zhao, J Wang, J Wang, Y Li, Y Li, G Murtaza, G Murtaza, J Chen, J Chen, W Wang, W Wang ...

  18. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. Chunhua Zhao. Articles written in Journal of Genetics. Volume 90 Issue 3 December 2011 pp 409-425 Research Article. Wheat kernel dimensions: how do they contribute to kernel weight at an individual QTL level? Fa Cui Anming Ding Jun Li Chunhua Zhao Xingfeng Li Deshun Feng ...

  19. Structure analysis and core community detection of embodied resources networks among regional industries

    Science.gov (United States)

    He, Xijun; Dong, Yanbo; Wu, Yuying; Wei, Guodan; Xing, Lizhi; Yan, Jia

    2017-08-01

    To address the double pressure of scarce resources and regional industrial isomorphism, this paper applied the concepts of exergy and embodied resources based on economic input-output (I-O) data. We constructed the embodied resources networks among the regional industries of Beijing-Tianjin-Hebei (also known as Jing-Jin-Ji) in China. We analyzed the rules of embodied resources consumption in the area's industries, identified the core community structures, and studied the characteristics of industrial homogeneity through regional comparisons. The results showed that the dependence on scarce resources of industrial operations in Beijing was less than in Jin-Ji, while the dependence on finance, technology, information, and other service resources in Beijing was higher than in Jin-Ji. The I-O efficiency of embodied resources among industries and the agglomeration of correlation relationships in industries with large embodied resources were higher than in Jin-Ji. The industrial coincidence degree in the ;bridge; industries and in the core community in Jin-Ji was higher than in Jing-Jin and Jing-Ji, which means the industrial homogeneous competition of Jin-Ji was higher, too. This study makes a significant contribution toward promoting the dislocation development of regional industries, accelerating the coordination of resources, and reducing homogeneity competition.

  20. 75 FR 60761 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-10-01

    ... related to drug resistance. Inventors: Genbin Shi, Gary Shaw, Xinhua Ji (NCI). Patent Status: U.S... Publications: 1. Blaszczyk J, Shi G, Li Y, Yan H, Ji X. Reaction trajectory of pyrophosphoryl transfer...: 15016362]. 2. Blaszczyk J, Shi G, Yan H, Ji X. Catalytic center assembly of HPPK as revealed by the crystal...

  1. An n-dimensional pseudo-differential operator involving the Hankel ...

    Indian Academy of Sciences (India)

    ji =0 bji x. 2 ji +μ+1/2 i. (x−1 i ∂/∂xi )ri + ji. (x. −μ−1/2 i φ(x1,..., xn)). ⎞. ⎠ ,. (1.8) where the bji are constants depending only on μ. For i = 1, 2,..., n, let (xi , yi , zi ) ...

  2. Blogs and Wikis as Instructional Tools: A Social Software Adaptation of Just-in-Time Teaching

    Science.gov (United States)

    Higdon, Jude; Topaz, Chad

    2009-01-01

    Just-in-Time Teaching (JiTT) methodology uses Web-based tools to gather student responses to questions on preclass reading assignments. However, the technological requirements of JiTT and the content-specific nature of the questions may prevent some instructors from implementing it. Our own JiTT implementation uses publicly and freely available…

  3. Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.

    Science.gov (United States)

    Walker, Sarah E; Zhou, Fujun; Mitchell, Sarah F; Larson, Victoria S; Valasek, Leos; Hinnebusch, Alan G; Lorsch, Jon R

    2013-02-01

    Eukaryotic translation initiation factor (eIF)4B stimulates recruitment of mRNA to the 43S ribosomal pre-initiation complex (PIC). Yeast eIF4B (yeIF4B), shown previously to bind single-stranded (ss) RNA, consists of an N-terminal domain (NTD), predicted to be unstructured in solution; an RNA-recognition motif (RRM); an unusual domain comprised of seven imperfect repeats of 26 amino acids; and a C-terminal domain. Although the mechanism of yeIF4B action has remained obscure, most models have suggested central roles for its RRM and ssRNA-binding activity. We have dissected the functions of yeIF4B's domains and show that the RRM and its ssRNA-binding activity are dispensable in vitro and in vivo. Instead, our data indicate that the 7-repeats and NTD are the most critical domains, which mediate binding of yeIF4B to the head of the 40S ribosomal subunit via interaction with Rps20. This interaction induces structural changes in the ribosome's mRNA entry channel that could facilitate mRNA loading. We also show that yeIF4B strongly promotes productive interaction of eIF4A with the 43S•mRNA PIC in a manner required for efficient mRNA recruitment.

  4. Joint implementation - project simulation and organisation. Operationalization of a new instrument of climate policy

    International Nuclear Information System (INIS)

    Luhmann, H.J.; Ott, H.E.; Beuermann, C.; Fischedick, M.; Hennicke, P.; Bakker, L.

    1997-01-01

    The study served to analyze the practical aspects of 'Joint Implementation' (JI) under the Framework Convention on Climate Change, in which measures to reduce greenhouse gas emissions are carried out jointly by several countries. As a first step, possible climate protection measures were assessed with respect to their suitability for JI and an overview of suitable JI projects was compiled. In a further step, carried out in cooperation with partners from industry, four specific projects (coal-fired power plant, solar-thermal power plant, cement factory, least-cost planning) were used to simulate JI. In this work, solutions were developed for the calculation of greenhouse gas emissions avoided as well as for project reporting. In addition, proposals were made with respect to the organizational and institutional design on an international JI mechanism. (orig.) [de

  5. Application of a lipid-coated hollow calcium phosphate nanoparticle in synergistic co-delivery of doxorubicin and paclitaxel for the treatment of human lung cancer A549 cells

    Directory of Open Access Journals (Sweden)

    Wu C

    2017-10-01

    Full Text Available Chao Wu, Jie Xu, Yanna Hao, Ying Zhao, Yang Qiu, Jie Jiang, Tong Yu, Peng Ji, Ying Liu Pharmacy School, Jinzhou Medical University, Jinzhou, China Abstract: In this study, we developed a lipid-coated hollow calcium phosphate (LCP nanoparticle for the combined application of two chemotherapeutic drugs to human lung cancer A549 cells. Hydrophilic doxorubicin (DOX was incorporated into the hollow structure of hollow calcium phosphate (HCP, and a lipid bilayer containing hydrophobic paclitaxel (PTX was subsequently coated on the surface of HCP. The study on combinational effects demonstrated that the combination of DOX and PTX at a mass ratio of 12:1 showed a synergistic effect against A549 cells. The particle size, zeta potential, and encapsulation efficiency were measured to obtain optimal values: particle size was 335.0 3.2 nm, zeta potential -41.1 mV, and encapsulation efficiency 80.40%±2.24%. An in vitro release study indicated that LCP produced a sustained drug release. A549 cells had a better uptake of LCP with good biocompatibility. Furthermore, in vitro cytotoxicity experiment, apoptosis analysis, in vivo anti-tumor efficacy and protein expression analysis of Bax, Bcl-2, and Caspase-3 demonstrated that the co-delivery system based on LCP had significant synergistic anti-tumor activity. All conclusions suggested that LCP is a promising platform for co-delivery of multiple anti-tumor drugs. Keywords: doxorubicin, paclitaxel, co-delivery, lipid, hollow calcium phosphate, lung cancer cell

  6. Wall Street som kreationistisk forkynder

    DEFF Research Database (Denmark)

    Ekman, Susanne

    2016-01-01

    Artiklen gennemgår Karen Hos etnografi om Wall Street: "Liquidated: An ethnography of Wall Street" set i lyset af den offentlige debat vedrørende Goldman Sachs opkøb af Dong......Artiklen gennemgår Karen Hos etnografi om Wall Street: "Liquidated: An ethnography of Wall Street" set i lyset af den offentlige debat vedrørende Goldman Sachs opkøb af Dong...

  7. Fièvre bilieuse hémoglobinurique (FBH) de révélation tardive: à ...

    African Journals Online (AJOL)

    Fièvre bilieuse hémoglobinurique (FBH) de révélation tardive: à propos d'un cas au CHU de Dakar. Aliou Thiongane, Aliou Abdoulaye Ndongo, Papa Moctar Faye, Assane Sylla, Younoussa Kéïta, Djibril Boiro, Idrissa Basse, Ndèye Ramatoulaye Diagne Guèye, Ousmane Ndiaye ...

  8. Study on strategies in joint implementation and its improvement to reduce CO2 emissions; CO2 sakugen no tame no kyodo jisshi ni okeru senryaku oyobi sono kaizen hosaku no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Matsuhashi, R.; Ishitani, H. [The University of Tokyo, Tokyo (Japan)

    1998-10-01

    In order to reduce greenhouse gas emissions, we have to introduce measures to suppress economic differences between developed countries (DC) and less developed countries (LDC) as well as accelerate technology improvement. In this sense, Joint Implementation (JI) is a promising measure not only to economically reduce greenhouse gas emissions, but also to facilitate technology transfer from DC to LDC. In this article, we first investigated JI strategies, in which LDC can improve industrial energy efficiency under financial support of DC. Strategies of countries involved in JI was represented with Stackelberg game. Analytical results revealed that JI activities may considerably be diminished in Stackelberg equilibrium, depending on shapes of the marginal cost functions of reducing CO2. Therefore we proposed measures to prevent the suppression of JI and quantitatively evaluated the potential of this improved JI system. As far as actual data on economy and industry are concerned, we used the ones of Japan and China, since China has been rapidly increasing its economic scale and greenhouse gas emissions. However implications from these analyses are useful also for other countries. 8 refs., 7 figs.

  9. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. ZI-JING ZHANG. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ...

  10. Lnc-ing inflammation to disease

    CSIR Research Space (South Africa)

    Magagula, L

    2017-08-01

    Full Text Available by RNAi more than by antisense oligonucleotides. Nucleic Acids Res. 44, 863–877 doi:10.1093/nar/gkv1206 75 Zhen, S., Hua, L., Liu, Y.-H., Sun, X.-M., Jiang, M.-M., Chen, W. et al. (2017) Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated...

  11. Filtering reaction dynamics using nearside-farside theory and local angular momentum theory: application to the angular scattering of the H + D2(v(i) = 0, j(i) = 0) --> HD(v(f) = 3, j(f) = 0) + D reaction in the energy and time domains.

    Science.gov (United States)

    Monks, P D D; Connor, J N L; Bouakline, F

    2009-04-23

    We investigate methods for filtering reaction mechanisms in the angular scattering of the state-to-state reaction, H + D(2)(v(i) = 0, j(i) = 0, m(i) = 0) --> HD(v(f) = 3, j(f) = 0, m(f) = 0) + D, where v(i), j(i), and m(i) and v(f), j(f), and m(f) are initial and final vibrational, rotational, and helicity quantum numbers, respectively. The input to our filtrations is a new set of accurate quantum scattering matrix elements for total energies in the range 1.52-2.50 eV (in steps of 0.01 eV) and for total angular momentum quantum numbers in the range, 0-40, in steps of unity. We filter reaction mechanisms in both the energy domain and the time domain. The time-domain calculations employ the plane wave packet formulation of time-dependent scattering. The theoretical tools used are nearside-farside (NF) analysis of partial wave series for scattering amplitudes, together with NF local angular momentum (LAM) theory. An energy-domain LAM analysis reveals the existence of an important dynamical feature in the N scattering, a "trench" which bisects the (energy, angle) plane. We use the location of this trench to approximately filter two reaction mechanisms. Transformation to the time domain demonstrates that the two reaction mechanisms correspond to direct and delayed (by about 25 fs) scattering. Further analysis, including filtration in the time domain, shows that the pronounced LAM trench arises from the interference of the energy-domain analogues of the time-direct and time-delayed scattering. Our theory and results provide the first successful demonstration of reaction mechanism filtering carried out directly in the (energy, angle) domain. The calculations and results in this paper extend and complement earlier research reported by Monks, Connor, and Althorpe (Monks, P. D. D.; Connor, J. N. L.; Althorpe, S. C. J. Phys. Chem. A 2006, 110, 741; J. Phys. Chem. A 2007, 111, 10302).

  12. Differentiation between serological responses to Brucella suis and Yersinia enterocolitica serotype O : 9 after natural or experimental infection in pigs

    DEFF Research Database (Denmark)

    Jungersen, Gregers; Sørensen, Vibeke; Giese, Steen Bjørck

    2006-01-01

    with responses of B. suis biovar 2-inoculated pigs. FPSR were limited to 2-9 weeks post-YeO:9 inoculation, while B. suis-infected pigs were test-positive throughout the 21-week period of investigation. Although YeO:9-inoculated pigs exhibited FPSR in Brucella tests for a limited period of time, the serological...

  13. Regulering, ikke kriminalisering

    DEFF Research Database (Denmark)

    Ludvigsen, Stian Skår; Sieberg, Katri K.

    2007-01-01

    Kriminalisering av horekunder vil føre til at markedet for seksuelle tjenester skyves inn i det skjulte.  Skjer dette, kan kostnadene bli høye.......Kriminalisering av horekunder vil føre til at markedet for seksuelle tjenester skyves inn i det skjulte.  Skjer dette, kan kostnadene bli høye....

  14. Spectrum-effect relationships between high performance liquid ...

    African Journals Online (AJOL)

    promoting effect on contractility of intestinal smooth was carried out to ... addition, the equation of spectrum-effect relationships {Y = 3.818 - 1.126X1 + ..... Peng W, Liu YJ, Wu N, Sun T, He XY, Gao YX, Wu CJ. ... Zheng QF, Zhao YL, Wang JB, Liu TT, Zhang B, Gong ... Zhao HY, Han X. Research thoughts and application.

  15. Modelled glacier dynamics over the last quarter of a century at Jakobshavn Isbræ

    DEFF Research Database (Denmark)

    Muresan, Ioana Stefania; Khan, Shfaqat Abbas; Aschwanden, Andy

    2016-01-01

    Observations over the past 2 decades show substantial ice loss associated with the speed-up of marineterminating glaciers in Greenland. Here we use a regional three-dimensional outlet glacier model to simulate the behaviour of Jakobshavn Isbræ (JI) located in western Greenland. Our approach...... is to model and understand the recent behaviour of JI with a physical process-based model. Using atmospheric forcing and an ocean parametrization we tune our model to reproduce observed frontal changes of JI during 1990-2014. In our simulations, most of the JI retreat during 1990-2014 is driven by the ocean...

  16. Modelled glacier dynamics over the last quarter of a century at Jakobshavn Isbræ

    DEFF Research Database (Denmark)

    Muresan, Ioana Stefania; Khan, Shfaqat Abbas; Aschwanden, Andy

    2016-01-01

    Observations over the past 2 decades show substantial ice loss associated with the speed-up of marineterminating glaciers in Greenland. Here we use a regional three-dimensional outlet glacier model to simulate the behaviour of Jakobshavn Isbræ (JI) located in western Greenland. Our approach...... is to model and understand the recent behaviour of JI with a physical process-based model. Using atmospheric forcing and an ocean parametrization we tune our model to reproduce observed frontal changes of JI during 1990-2014. In our simulations, most of the JI retreat during 1990-2014 is driven by the ocean...... parametrization used and the glacier's subsequent response, which is largely governed by bed geometry. In general, the study shows significant progress in modelling the temporal variability of the flow at JI. Our results suggest that the overall variability in modelled horizontal velocities is a response...

  17. Didaktisko spēļu izmantošana apkārtnes mācību stundās skolēniem ar vidēji smagiem garīgās attīstības traucējumiem

    OpenAIRE

    Zarecka, Tatjana

    2007-01-01

    Diplomarba tēma ir „Didaktisko spēļu izmantošana apkārtnes mācību stundās skolēniem ar vidēji smagiem un smagiem garīgās attīstības traucējumiem”. Pētījuma mērķis: Diplomdarbā teoretiskajā daļā tiek apskatītās pedagoģiskās atziņas par didaktiskajām spēlēm: pedagogus F.Frēbeļa, M.Montesori, K.Ušinska, J.Tihejevas, A.Sorokinas, A.Bondarenko, O.Svenne, I.Kapostas darbu apskats; tiek analizēts terminu „spēle” un „rotaļa” salidzinājums; tiek apskatīta didaktisko spēļu klasifikācija; tiek a...

  18. Stemcell Information: SKIP000586 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Lei Ye Lei Ye Division of Cardiology, Department of Medicine, University of Mi...nnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Department... of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology...l, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Department of Medicine, Univers

  19. A new compactness type topological property | Zhao | Quaestiones ...

    African Journals Online (AJOL)

    By a gauge on a topological space we shall mean a mapping that assigns each element in the space an open neighbourhood. We investigate some topological properties which can be characterized using gauges. The main property we will consider is the gauge compactness. Some problems and possible future work are ...

  20. C. Huang , G. Zhao , HW Zhang & YQ Chen

    Indian Academy of Sciences (India)

    the host stars' birth cloud with higher abundance of Si will make the cloud ... with the metallicity distribution of nearby field F, G, or K stars which are known to .... In the early stage of planetesimal accumulation, the rate of growth of planetesimal.

  1. Lanostane triterpenoids from Ganoderma hainanense J. D. Zhao.

    Science.gov (United States)

    Peng, XingRong; Liu, JieQing; Xia, JianJun; Wang, CuiFang; Li, XuYang; Deng, YuanYuan; Bao, NiMan; Zhang, ZhiRun; Qiu, MingHua

    2015-06-01

    Chemical investigation of the fruiting bodies of Ganoderma hainanense resulted in isolation of fourteen lanostane triterpenoids, including nine ganoderma acids and five ganoderma alcohols, together with five known compounds. Structural elucidation was determined using extensive spectroscopic technologies, Mosher's method and X-ray single crystal diffraction. Three of the compounds showed inhibitory activities against HL-60, SMMC-7721, A-549 and MCF-7 cells with IC50 values of 15.0-40.0 μM. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Author Details

    African Journals Online (AJOL)

    Bai, Peter J. Vol 15, No 2 (2016) - Articles Neuroprotective effect of Zhen Tian Wan on pial strip-induced cognitive impairments and anti-oxidant status in rats. Abstract PDF. ISSN: 1118-1028. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  3. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  4. Otvlekajas na zhizn / Tatjana Poznjak

    Index Scriptorium Estoniae

    Poznjak, Tatjana

    2000-01-01

    Vene kirjaniku Ivan Bunini (1870-1953) elulõpu armastusloost tehtud filmis "Tema naise päevik" ("Dnevnik jego zhenõ") on Bunini rollis Andrei Smirnov. Näitleja räägib oma suhtest rolliga ning artikli autor avaldab mõtteid kirjaniku elu ja iseloomu üle. Ka ajalehes Vesti : Nedelja pljuss, 15. detsember, lk. 32-33

  5. Laureatõ kinopremii "Nika"

    Index Scriptorium Estoniae

    2001-01-01

    Venemaa Kinoakadeemia auhinna "Nike" laureaadid vene filmitegijate seast 2000.a. tööde eest. Auhind "Au ja väärikuse" eest anti Vjatsheslav Tihhonovile. Parima filmi tiitli sai Aleksei Utshiteli "Tema naise päevik" ("Dnevnik jego zhenõ"), parim režissöör oli Bahtijer Hudoinazarov filmi "Kuu isaks" ("Lunnõi papa") eest

  6. The potential application of a transcriptionally regulated oncolytic herpes simplex virus for human cancer therapy

    Science.gov (United States)

    Miao, L; Fraefel, C; Sia, K C; Newman, J P; Mohamed-Bashir, S A; Ng, W H; Lam, P Y P

    2014-01-01

    Background: Emerging studies have shown the potential benefit of arming oncolytic viruses with therapeutic genes. However, most of these therapeutic genes are placed under the regulation of ubiquitous viral promoters. Our goal is to generate a safer yet potent oncolytic herpes simplex virus type-1 (HSV-1) for cancer therapy. Methods: Using bacterial artificial chromosome (BAC) recombineering, a cell cycle-regulatable luciferase transgene cassette was replaced with the infected cell protein 6 (ICP6) coding region (encoded for UL39 or large subunit of ribonucleotide reductase) of the HSV-1 genome. These recombinant viruses, YE-PC8, were further tested for its proliferation-dependent luciferase gene expression. Results: The ability of YE-PC8 to confer proliferation-dependent transgene expression was demonstrated by injecting similar amount of viruses into the tumour-bearing region of the brain and the contralateral normal brain parenchyma of the same mouse. The results showed enhanced levels of luciferase activities in the tumour region but not in the normal brain parenchyma. Similar findings were observed in YE-PC8-infected short-term human brain patient-derived glioma cells compared with normal human astrocytes. intratumoural injection of YE-PC8 viruses resulted in 77% and 80% of tumour regression in human glioma and human hepatocellular carcinoma xenografts, respectively. Conclusion: YE-PC8 viruses confer tumour selectivity in proliferating cells and may be developed further as a feasible approach to treat human cancers. PMID:24196790

  7. Neuroprotective Effect of Zhen Tian Wan on Pial strip-Induced ...

    African Journals Online (AJOL)

    toshiba

    effects on ischemia-induced neuronal injury. ... continuous access to food and water and were ... surgeries head position was adjusted to place ... (2.0m in diameter, 0.35m high) constructed of ... of the protein sample was combined with the.

  8. DONG JIE Zhang, LIANG Wang, ZHON

    Indian Academy of Sciences (India)

    User

    development, hairless nude skin, and short life (Abitbol et al., 2015; Bryson et al., 2013). On the ... Foxn1 maintains TECs to support T-cell development via mcm2 ... were ligated upstream of the firefly luciferase gene in the plasmid pGL3-Basic.

  9. Russian energy efficiency projects: lessons learnt from Activities Implemented Jointly pilot phase

    International Nuclear Information System (INIS)

    Korppoo, Anna

    2005-01-01

    Russia needs to improve the efficiency of energy. Failure to do so will retard the economic recovery of the country, but the energy sector is lacking both domestic and foreign investments. JI projects could provide the underfinanced Russian energy sector with additional investments. AIJ pilot project experiences provide an overview of the potential difficulties for future JI projects. Institutional problems were the most important category. Most of these problems remain, and the lack of ratification of the Kyoto Protocol by Russia has formed a new very significant barrier. Implementation level problems caused some problems to AIJ projects, but they are likely to have less impact on the better prepared JI projects. The character of funding-related problems has changed: for AIJ projects the main problem was that emission reductions could not be credited, whereas future JI projects will experience more competition in the Kyoto market where the overall investment climate and the availability of local cofunding are more relevant. Therefore, the unfinished economic and energy sector reforms currently discourage JI investments. The project experiences so far have been dismal, and if Russian policy-makers cannot improve this performance, only few JI projects can be expected in the future

  10. Deep Tunnel for Regulating Combined Sewer Overflow Pollution and Flood Disaster: A Case Study in Guangzhou City, China

    Directory of Open Access Journals (Sweden)

    Haichun Wu

    2016-08-01

    Full Text Available The DongHaoChong (DHC basin is located in the central city zone of Guangzhou City, China. Owing to the high density of buildings and low quality of the drainage pipe network in the city, diversion of rain and sewage is difficult. Waterlogging occurs frequently and combined sewer overflow (CSO pollution is a serious problem during the rainy season. Therefore, a deep tunnel for the DongHaoChong basin has been planned and its construction is currently underway. An urban rainstorm model for the DongHaoChong basin was developed on the basis of the Storm Water Management Model (SWMM, and both the interception effect of CSO pollution and the degree of mitigation of flood were analyzed. Reasonable scenarios for the deep tunnel in terms of rainstorms with different design recurrence periods were evaluated. From the viewpoints of preventing rainstorm waterlogging disasters and protecting water quality in the region downstream of DongHaoChong River, the river flood control and drainage capacities of the region were improved to a 2-year rainstorm design recurrence period by the construction of the deep tunnel. Furthermore, the main pollutant load of the CSO is expected to be reduced by about 30%–40%.

  11. DNA characterization and polymorphism of KISS1 gene in Egyptian ...

    African Journals Online (AJOL)

    Aghomotsegin

    2015-07-29

    Jul 29, 2015 ... effect on litter size performance and many studies were carried out to identify ... gene (Wang et al., 2011), kit ligand (KITLG) gene (An et al., 2012) and bone ..... An XP, Han P, HouJX, Zhao HB, Yan Y, Ma T, Fang F, MengFX, Song. YX, Wang JG ... Chu MX, Zhao XH, Zhang YJ, Jin M (2010). Polymorphisms ...

  12. AcEST: BP912503 [AcEST

    Lifescience Database Archive (English)

    Full Text Available n sp|Q96JI7|SPTCS_HUMAN Spatacsin OS=Homo sapiens Align length 47 Score (bit) 32.....................done Score E Sequences producing significant alignments: (bits) Value sp|Q96JI7|SPTCS_HUMAN Spatacsi...e transporter-like protein 3 OS=Bos t... 30 6.4 >sp|Q96JI7|SPTCS_HUMAN Spatacsin OS=Homo sapiens GN=SPG11 PE

  13. Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

    Directory of Open Access Journals (Sweden)

    Zhang W

    2016-05-01

    Full Text Available Wen Zhang,1,* Li Wei,2,* Wenjing Yu,1 Xia Cui,1 Xiaofang Liu,2 Qian Wang,1 Sumei Wang2 1Department of Pediatrics, The Third Affiliated Hospital, 2Department of Pediatrics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Jian-Pi-Zhi-Dong Decoction (JPZDD is a dedicated treatment of Tourette syndrome (TS. The balance of neurotransmitters in the cortico-striato-pallido-thalamo-cortical network is crucial to the occurrence of TS and related to its severity. This study evaluated the effect of JPZDD on glutamate (Glu and γ-aminobutyric acid (GABA and their receptors in a TS rat model.Materials and methods: Rats were divided into four groups (n=12 each. TS was induced in three of the groups by injecting them with 3,3'-iminodipropionitrile for 7 consecutive days. Two model groups were treated with tiapride (Tia or JPZDD, while the control and the remaining model group were gavaged with saline. Behavior was assessed by stereotypic score and autonomic activity. Striatal Glu and GABA contents were detected using microdialysis. Expressions of N-methyl-D-aspartate receptor 1 and GABAA receptor (GABAAR were observed using Western blot and real-time polymerase chain reaction.Results: Tia and JPZDD groups had decreased stereotypy compared with model rats; however, the JPZDD group showed a larger decrease in stereotypy than the Tia group at a 4-week time point. In a spontaneous activity test, the total distance of the JPZDD and Tia groups was significantly decreased compared with the model group. The Glu levels of the model group were higher than the control group and decreased with Tia or JPZDD treatment. The GABA level was higher in the model group than the control group. Expressions of GABAAR protein in the model group were higher than in the control group. Treatment with Tia or JPZDD reduced the expression of GABAAR protein. In the case of the m

  14. miR-30a suppresses osteosarcoma proliferation and metastasis by downregulating MEF2D expression

    Directory of Open Access Journals (Sweden)

    Du L

    2018-04-01

    Full Text Available Liuxue Du,* Tianpei Chen,* Kai Zhao,* Dong Yang Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China *These authors contributed equally to this work Abstract: Many studies have revealed that microRNAs (miRNAs play crucial roles in cancer development and progression. miRNA-30a (miR-30a, as a member of the miR-30 family, has been implicated in various cancers. However, the role of miR-30a in osteosarcoma remains unclear. In the current study, we found that miR-30a was significantly downregulated in osteosarcoma tissues and cell lines by using quantitative real-time polymerase chain reaction (qRT-PCR. In addition, miR-30a could inhibit cancer cell growth, migration, and invasion in vitro. Furthermore, bioinformatics of miRNA target prediction and luciferase reporter assay indicated that MEF2D is a direct target of miR-30a. miR-30a was able to reduce the mRNA and protein expression of MEF2D as assessed using RT-PCR and Western blotting assay. Interestingly, overexpression of MEF2D partially reversed the miR-30a-reduced cell proliferation, migration, and invasion of osteosarcoma cell, indicating that miR-30a suppresses osteosarcoma cell proliferation and metastasis partially mediated by inhibition of MEF2D. Overall, our study demonstrated that miR-30a functions as a tumor suppressor by targeting MEF2D in osteosarcoma, providing a promising prognostic biomarker and a therapeutic strategy for osteosarcoma. Keywords: miR-30a, MEF2D, osteosarcoma, proliferation, invasion, migration

  15. PC-3 Prostat Kanser Hücreleri Üzerinde İndosyanin Yeşili Kullanarak Yapılan Fotodinamik Terapinin AO/PI Boyama Testi Sonuçları

    Directory of Open Access Journals (Sweden)

    Mustafa Kemal RUHİ

    2017-06-01

    Full Text Available Fotodinamik terapi (FDT prostat kanseri tedavisinde henüz araştırma aşamasında olan sağaltıcı bir alternatiftir. FDT, ışığa duyarlı bir kimyasal maddenin (fotosensitizan ışık ile aktive edilmesi ve aktive olan kimyasalın kanserli bölgedeki hücre canlılığını baskılayıcı etkiye neden olması prensibine dayanmaktadır. Bu yeni tedavi yöntemi hem seçiciliği hem de yan etkilerinin azlığı nedeniyle alternatifler arasında ön plana çıkmaktadır. FDT’de kullanılan fotosensitizanın ışıksız ortamda sitotoksik olmaması ve vücuttan kolay atılabilmesi istenmektedir. Ayrıca herhangi bir fotosensitizanın yakın kızılaltı ışık ile aktive olması, bu dalgaboyunun deriye ve diğer dokulara daha fazla nüfuz etmesinden dolayı tercih sebebidir. Bu özelliklere sahip olan İndosiyanin Yeşili (ISY daha çok floresans özelliği ile ön plana çıkmış ve görüntüleme amaçlı olarak kullanılmıştır. Bu in vitro çalışmada ISY-FDT’nin farklı inkübasyon süreleri sonundaki etkisi AO/PI boyama yöntemi kullanarak ortaya konmuştur. Elde edilen sonuçlar ISY-FDT’nin hücre canlılığını baskıladığını göstermektedir.

  16. Allah’ın Varlığını Aklen Bilmeye İlişkin Mâtürîdî'nin Gâye ve Nizam Delili / The Argument of “Hikmah and Tadbir” to Prove The Existence of God According to al-Maturidi

    Directory of Open Access Journals (Sweden)

    Fatma Aygün

    2015-05-01

    Full Text Available Öz Mâtürîdî İslâm düşünce tarihinde önemli bir yere sahip bulunan düşünürlerden biridir. Öyle ki Mâtürîdî (333/944 Ebû Hanîfe geleneğinin en güçlü simasıdır ve Ehl-i Sünnet kelâmının kuruluşunda en büyük paya sahiptir. Mâtürîdî'nin düşüncesinde "hikmet" ve "tedbîr" kavramları çok önemli bir yere sahiptir, o Allah'ın varlığını bilmek için hikmet ve tedbîr terimleriyle ilşkilendirdiği gâye ve nizam delilini kullanmıştır. Ayrıca o kötülük (şer olarak gördüğümüz şeyler dahil var olan tüm şeylerin "hikmet"in bir tezahürü olarak ortaya çıktığından bahsetmiştir. Mâtürîdî'nin düşünce sisteminde Allah'ın varlığı bilmek için kullanılan teleolojik delil ki doğadaki düzenlilik, güzellik ve tedbirin gözlemlerinden, analojik veya endüktif muhakemenin bazı türleri aracılığıyla ilerler, sonuç olarak bunlar bir tasarımcının (Allah işi olmalıdır. Bu Makalede gâye ve nizam delili ile ilgili Mâtürîdî'nin evrendeki düzeni ispat etmeye yönelik ortaya koymuş olduğu argümanlar ayrı başlıklar halinde ele alınmış ve tartışılmıştır. Anahtar Kelimeler: Kelâm, Mâtürîdî, Allah'ın Varlığının Delilleri, Hikmet, Tedbîr, Gâye ve Nizâm Delili (Teleolojik Delil. The Argument of “Hikmah and Tadbir” to Prove The Existence of God According to al-Maturidi Abstract Al-Maturidi is one of the foremost and most important thinkers in the history of Islamic thought. So that al-Maturidi (333/944 is the most powerful figure in Ebû Hanîfe School and has the biggest share in the establishment of Followers of Sunnah kalam. The "hikmah" (wisdom and "tadbir" (order concepts are very important terms in the thought of al-Maturidi. He used the argument of “aim and order" (teleological argument -that he links with the term hikmah and tadbir- to prove the existence of God. He also stated that all things, including even the bad things (malignity, come

  17. Stemcell Information: SKIP000588 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Lei Ye Lei Ye Division of Cardiology, Department of Medicine, University of M...innesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Departmen...t of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology...ol, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Department of Medicine, Univer

  18. Stemcell Information: SKIP000584 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Lei Ye Lei Ye Division of Cardiology, Department of Medicine, University o...f Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Depart...ment of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology...chool, Minneapolis, Minnesota, United States of America ... Division of Cardiology, Department of Medicine, Uni

  19. Next-generation sequence detects ARAP3 as a novel oncogene in papillary thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Wang QX

    2016-11-01

    Full Text Available Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Yi-Li Zhou, Zhou-Ci Zheng, Ying-Hao Wang, Yi-Xiang Jin, Wen-Xu Jin, Xiao-Hua Zhang, Ou-Chen Wang Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China Purpose: Thyroid cancer is the most frequent malignancies of the endocrine system, and it has became the fastest growing type of cancer worldwide. Much still remains unknown about the molecular mechanisms of thyroid cancer. Studies have found that some certain relationship between ARAP3 and human cancer. However, the role of ARAP3 in thyroid cancer has not been well explained. This study aimed to investigate the role of ARAP3 gene in papillary thyroid carcinoma. Methods: Whole exon sequence and whole genome sequence of primary papillary thyroid carcinoma (PTC samples and matched adjacent normal thyroid tissue samples were performed and then bioinformatics analysis was carried out. PTC cell lines (TPC1, BCPAP, and KTC-1 with transfection of small interfering RNA were used to investigate the functions of ARAP3 gene, including cell proliferation assay, colony formation assay, migration assay, and invasion assay. Results: Using next-generation sequence and bioinformatics analysis, we found ARAP3 genes may play an important role in thyroid cancer. Downregulation of ARAP3 significantly suppressed PTC cell lines (TPC1, BCPAP, and KTC-1, cell proliferation, colony formation, migration, and invasion. Conclusion: This study indicated that ARAP3 genes have important biological implications and may act as a potentially drugable target in PTC. Keywords: papillary thyroid carcinoma, next-generation sequence, ARAP3, oncogene

  20. Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

    Directory of Open Access Journals (Sweden)

    Jiao J

    2013-06-01

    Full Text Available Jie Jiao,1,4 Lu Huang,1 Feng Ye,1 MinFeng Shi,2 XiaoDong Cheng,3 XinYu Wang,3 DongXiao Hu,3 Xing Xie,3 WeiGuo Lu31Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 2Department of Gynaecology and Obstetrics, Changhai Hospital, the Second Military Medical University, Shanghai, 3Women's Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 4Department of Gynaecology and Obstetrics, Hangzhou First People's Hospital, Hangzhou, People's Republic of ChinaBackground: The association of cancer stem cells with epithelial–mesenchymal transition (EMT is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activation, but its effect on the EMT mechanism in ovarian cancer stem cells is unclear.Methods: The anchorage-independent spheroids from ovarian adenocarcinoma cell line 3AO were formed in a serum-free medium. CD24- and CD24+ cells were isolated by fluorescence-activated cell sorting. Cell morphology, viability, apoptosis, and migratory ability were observed. Stem-related molecule Bmi-1, Oct-4 and EMT-related marker E-cadherin, and vimentin expressions were analyzed. Cyclin D1 expression in CD24- phenotype enriched spheroids was knocked down with small interfering RNA, and its effects on cell proliferation, apoptosis, migration ability, and EMT-related phenotype after transfection were observed. Results: In our study, CD24- cells presented stronger proliferative, anti-apoptosis capacity, and migratory ability, than CD24+ cells or parental cells. CD24- cells grew with a scattered spindle-shape within 3 days of culture and transformed into a cobblestone-like shape, identical to CD24+ cells or parental cells at 7

  1. The Climate for Joint Implementation. Case Studies from Russia, Ukraine, and Poland

    Energy Technology Data Exchange (ETDEWEB)

    Evans, M.; Legro, S.; Popov, I. [Pacific Northwest National Laboratory, Washington, DC (United States)

    2000-07-01

    Joint implementation (JI) can provide flexibility in meeting Kyoto Protocol commitments, and 44 nations have already participated in the UN. Framework Convention on Climate Change - Activities Implemented Jointly (AIJ) pilot. This paper surveys JI policy and projects in three countries - Russia, Ukraine, and Poland - over the past five years and examines the effects of domestic institutions, foreign policy, and investment trends on JI in each country. The institutional and economic situation in the three nations differs greatly, and these distinctions have resulted in very different circumstances for AIJ projects, affecting both their number and scope. Poland has a well-defined set of rules and procedures for JI and its economy is quite strong. Ukraine has not yet established criteria or clear procedures for AIJ project reviews although it does have an Interagency Commission on Climate Change. Ukraine's economy declined by over 40% in the 1990s. Russia's economy has also declined, to a lesser extent. Russia does have a procedure for reviewing AIJ projects, though it has temporarily halted these reviews. Countries seeking JI investment can take several steps to improve the number and quality of AIJ projects that they receive. In the long term, governments can create macroeconornic stability and a solid legal investment basis to attract investment for JI and other areas. In the short term, however, governments can undertake several simple and inexpensive steps to promote JI. Establishing clear rules and procedures for AIJ projects is an important step. So too are clearly delegating responsibility for AIJ project review and providing a single JI point of contact in the government to which investors and project developers can turn. Gaining more experience in implementing AIJ projects now is important preparation for fully implementing the Kyoto Protocol beginning in 2008. 28 refs.

  2. A Comparative Study of the Story Events in Literary and Cinematic Narrative: A Comparison between the Story of Ashghalduni (Dustbin and the Adapted Movie, Dayere-ye Mina (The Cycle

    Directory of Open Access Journals (Sweden)

    Z. Hayati

    2016-07-01

    Full Text Available The present article tries to study the story Ašghālduni (Dustbin by Gholāmhossein Sā’edi and the adapted movie Dāyere-ye Minā (The Cycle by Dāryuš Mehrjuyi with a view to new adaptation theories. Of course, these theories have not yet been consistent and well-established; but its literature is going to evolve, especially its essentials are discussed in the study method of narratology. As an example, this proposition is discussed in theoretical subjects of adaptation that even in the loyal adapted movies, in which the structure of the literary story and the sequence of events in the movie are preserved, some of the semantic functions change because of story entry into the cinematic discourse along with the needs of medium of cinema. For example, the figurative aspect of Sā’edi's story in its adapted movie has been influenced by the scheme and sometimes realism dominates symbolism. Mehrjuyi has organized the events in the discourse of classic cinema in order to encourage the reader to persist the events during a certain time period. The way of timing a movie in terms of a three-screen structure encourages the spectator to follow the events and causes the "scheme" to dominate the "idea". Since the dominance of either scheme or idea creates different themes, it can be said that the very structural change leads somewhat to semantic change. Similarly, the change of Sā’edi's open ending narrative to a close one prevents the audience to participate in re-making the fictional fate of Ali; the sort that exists in a literary text.

  3. Changing patient safety culture in China: a case study of an experimental Chinese hospital from a comparative perspective

    OpenAIRE

    Xu XP; Deng DN; Gu YH; Ng CS; Cai X; Xu J; Zhang XS; Ke DG; Yu QH; Chan CK

    2018-01-01

    Xiao Ping Xu,* Dong Ning Deng,* Yong Hong Gu, Chui Shan Ng, Xiao Cai, Jun Xu, Xin Shi Zhang, Dong Ge Ke, Qian Hui Yu, Chi Kuen Chan Clinical Service Department, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China *These authors contributed equally to this work Background: The World Health Organization highlights that patient safety interventions are not lacking but that the local context affects their successful implementation. Increasing att...

  4. Seismic imaging of North China: insight into intraplate volcanism and seismotectonics

    Science.gov (United States)

    Zhao, D.

    2004-12-01

    We used seismic tomography to study the detailed three-dimensional (3-D) seismic velocity structure of the crust and mantle beneath North China for understanding the intraplate volcanism and seismotectonics of the Asian continent. Two active volcanoes, Changbai and Wudalianchi, exist in Northeast China and they have erupted several times in the last 1000 years. The origin of the active intraplate volcanoes is still unclear. Global tomography shows that the subducting Pacific slab becomes stagnant under NE Asia and strong low-velocity (low-V) anomalies exist in the upper mantle under the two volcanoes (Zhao, 2004). Recently we determined a 3-D P-wave velocity structure under the Changbai volcano using teleseismic data recorded by 19 portable seismic stations in NE China (Zhao et al., 2004). Our result shows a columnar low-V anomaly extending to 400 km depth and high-velocity anomalies in the mantle transition zone with deep-focus earthquakes of about 600 km depth. These results indicatie that the Changbai and Wudalianchi volcanoes are not hotspot like Hawaii but a kind of back-arc volcano related to the deep subduction and stagnancy of the Pacific slab under NE Asia. A detailed 3-D P-wave tomography of the crust and uppermost mantle under the Beijing region is determined by using local earthquake arrival times recorded by the newly installed Chinese Capital Seismic Network with 101 short-period seismic stations coving the region densely and uniformly (Huang and Zhao, 2004). The results show that large crustal earthquakes, such as the 1679 Sanhe earthquake (M 8.0) and the 1976 Tangshan earthquake (M 7.8), generally occurred in high-velocity areas in the upper to middle crust. In the lower crust to the uppermost mantle under the source zones of the large earthquakes, however, low-velocity and high-conductivity anomalies exist, which are considered to be associated with fluids. The fluids in the lower crust may cause the weakening of the seismogenic layer in the upper

  5. The Challenge of Limiting Greenhouse Gas Emissions Through Activities implemented Jointly in Developing Countries: A Brazilian Perspective

    Energy Technology Data Exchange (ETDEWEB)

    La Rovere, E.L.

    1998-11-01

    This paper addresses, from the Brazilian perspective, the main problems with Joint Implementation/Activities Implemented Jointly (JI/AIJ) between industrialized (Annex I) and developing (non-Annex I) countries, as defined by the United Nations Framework Convention on Climate Change (UNFCCC). Four possible GHG emissions abatement measures are presented for Brazil: forest protection, reforestation projects for carbon sequestration or charcoal manufacturing, use of ethanol produced from sugar cane as a car fuel, and electrical energy conservation through an increase in end-use efficiencies. These four case studies form the basis of a discussion regarding the validity of developing countries' concerns about JI/AIJ. Recommendations are offered for overcoming the present shortcomings of JI/AIJ in developing countries. The primary conclusion is that Annex I countries' funding of JI/AIJ projects in developing countries in return for GHG emissions credits is not the best means to implement the UNFCCC. However, JI/AIJ projects can be a productive means of preventing global climate change if combined with other measures, including GHG emissions reduction targets for all countries involved in JI/AIJ projects and limits on the percentage of industrialized countries' emissions reductions that can be met through projects in developing countries.

  6. Multi-level natural resources governance based on local community: A case study on semi-natural grassland in Tarōji, Nara, Japan

    Directory of Open Access Journals (Sweden)

    Daisaku Shimada

    2015-09-01

    beneficiaries. This paper examines the multi-level management of a semi-natural grassland at Tarōji, in Soni village, in Nara prefecture. In Soni village, members of the local community provide key management input, while local government at the village and prefecture levels share management costs.

  7. Gemlik Çeşidi Salamura Zeytin Üretiminde Diffüzyon Katsayısının Belirlenmesi ve Farklı Tuz Derişiminin Laktik Asit ve İndirgen Şeker Üzerine Etkisi

    Directory of Open Access Journals (Sweden)

    Ömer Faruk Gamlı

    2016-11-01

    Full Text Available Bu çalışmada, farklı tuz derişimlerindeki (%8-14 salamuralar kullanılarak Osmaniye’de yetiştirilen Gemlik çeşidi yeşil ve siyah zeytinlerden sofralık, salamura zeytin üretimi gerçekleştirilmiştir. Salamuralardaki tuz konsantrasyonlarının artması ile birlikte yeşil zeytinlerde nem değerlerinin %45,23-54,90, siyah zeytinlerde %46,04-56,53 arasında değiştiği; yeşil zeytinlerde tuz miktarlarının %1,21-5,22 arasında, siyah zeytinlerde ise %2,32-5,57 arasında değiştiği belirlenmiştir. Artan tuz konsantrasyonlarına bağlı olarak yayılım katsayılarının da arttığı belirlenmiştir. Yeşil zeytinlerde yayılım katsayıları 4.38 × 10-8- 6,59 × 10-7 (m2s-1 arasında, siyah zeytinlerde ise 3,79 × 10-8 – 3,56 × 10-7 (m2s-1 arasında değişim göstermiştir. Yeşil siyah zeytinlerde laktik asit konsantrasyonlarının %0,43-0,45, siyah zeytinlerde ise %0,41-0.44 arasında değiştiği tespit edilmiştir. %10-12’ lik salamuralarda laktik asit oluşumunun diğerlerine oranla daha fazla olduğu belirlenmiştir. İndirgen şeker miktarlarının yeşil zeytinlerde olgunlaşmanın ilerlemesiyle birlikte %4,76-1,88, siyah zeytinlerde ise %4,89-2,01 arasında değişim gösterdiği görülmüştür.

  8. Development of perceived job insecurity across two years: Associations with antecedents and employee outcomes

    OpenAIRE

    Kinnunen U; Mäkikangas A; Mauno S; De Cuyper N; De Witte H

    2014-01-01

    This 2-year longitudinal study among 848 university employees investigated the individual development of perceived job insecurity (JI) in the context of changes occurring in the Finnish universities during the follow-up time. Adopting a person-oriented approach through latent profile analysis, 8 classes of employees with similar mean levels and mean-level changes in JI were identified. Two of these classes (75% of the participants) indicated stable (low, moderately high) JI, and the remaining...

  9. The Impacts of Different PBL Schemes on the Simulation of PM2.5 during Severe Haze Episodes in the Jing-Jin-Ji Region and Its Surroundings in China

    Directory of Open Access Journals (Sweden)

    Tian Li

    2016-01-01

    Full Text Available In this study, three schemes [Yonsei University (YSU, Mellor-Yamada-Janjic (MYJ, and Bougeault-Lacarrère (Boulac] were employed in the Weather Research and Forecasting/Chemistry (WRF-Chem model to simulate the severe haze that occurred in February 2014 in the Jing-Jin-Ji region and its surroundings. The PM2.5 concentration simulated using the three schemes, together with the meteorological factors closely related to PM2.5 (wind speed, local vertical diffusivity, and PBL height, was evaluated through comparison with observations. The results indicated that the eastern plain cities produced better simulation results than the western cities, and the cities under the eastern root of Taihang Mountain produced the worst results in simulating high PM2.5 concentration in haze. All three schemes simulated very similar variation trends of the surface PM2.5 concentration compared with observations. The diurnal variations of simulated surface PM2.5 were not as reasonable as their reflection of daily averaged variation. The simulated concentrations of surface PM2.5 using the YSU, MYJ, and Boulac schemes all showed large negative errors during daytime in polluted days due to their inefficient descriptions of local atmospheric stability or diffusion processes in haze. The lower ability of PBL schemes in distinguishing the diffusion between haze and clean days in the complex topography areas in China is an important problem for PM2.5 forecasting, which is worthy of being studied in detail.

  10. Cryogenic Peltier Cooling

    Science.gov (United States)

    2017-04-06

    modulation doping and anti-resonance scattering in core-shell nanoparticles to improve the electron performance. Initial simulation shows that this...shows the experimental data on thermoelectric (TE) properties of K doped Bi1-xSbx samples compared to the undoped sample. It is obvious that K ...techniques of chemical doping , the integration of Cu and Ag nanoparticles [H. Zhao, et al., Nanotechnology 23, 505402 (2012).], nanostructuring [H. Zhao

  11. Raudbetoonist vaade / Sveta Grigorjeva

    Index Scriptorium Estoniae

    Grigorjeva, Sveta, 1988-

    2016-01-01

    Arvustus: Billeneeve. Sügis nagu lõppev suhe : [luuletused]. Saarde ; Pärnu : [Jumalikud Ilmutused], 2015. (Ji ; 75) ; Ühe aknaga maailm : [luuletused]. Saarde ; Pärnu : [Jumalikud Ilmutused], 2016. (Ji ; 80)

  12. Parameter optimization using GA in SVM to predict damage level of non-reshaped berm breakwater.

    Digital Repository Service at National Institute of Oceanography (India)

    Harish, N.; Lokesha.; Mandal, S.; Rao, S.; Patil, S.G.

    tools, such as Artificial Neural Network (ANN), Support Vector Machine (SVM), Adaptive Neuro Fuzzy Inference System (ANFIS), etc., are successfully used in different fields (Kazperkiewiecz et al 1995, Voga and Belchior 2006, Dong et al 2005). Also... Balas C.E., Koc M.L. and Tur R.(2010) ‘’Artificial neural networks based on principal component analysis, fuzzy systems and fuzzy neural networks for preliminary design of rubble mound breakwaters’’, Applied Ocean Research, 32, 425 – 433. Dong B., Cao C...

  13. Portugal and Spain entering the Common Market: Their industrial competitiveness revisited

    OpenAIRE

    Donges, Jürgen B.; Schatz, Klaus-Werner

    1985-01-01

    The purpose of this paper is to assess the overall position as well as the relative strength and weakness of the Iberian manufacturing industries within an enlarged Community. Earlier studies of the authors (Donges, Schatzf 1980; Donges et al., 1982) are up-dated and extended to cover the bilateral trade relations between Portugal and Spain. Following a recapitulation of the major trade patterns of the Iberian countries, we examine the nature of their specialization, both with regard to the E...

  14. Joint implementation in energy between the EU and Russia Out look and potential

    International Nuclear Information System (INIS)

    Laroui, F.; Tellegen, E.; Tourilova, K.

    2004-01-01

    At the seventh Conference of Parties in Marrakech (COP 7) a consensus was reached on the rules, the modalities and the guidelines of the flexibility mechanisms of the Kyoto Protocol. In this paper we assess the outlook and potential of one of the flexibility mechanisms, viz. joint implementation (JI) between the European Union and Russia. We show that both parties have all the incentives to start working on JI and we assess the biggest obstacle for implementing JI

  15. Human needs as predictors for organizational commitment and job involvement: An exploratory empirical study

    OpenAIRE

    Park, Yang-Kyu; Lee, Chul-in; Kabst, Rüdiger

    2008-01-01

    While the literature on the determinants of organizational commitment (OC) and job involvement (JI) is vast, little has been studied about the impact of human needs. In search for the institutional stars, this study examines whether human needs can serve a predictor for both high OC and high JI. Exploratory empirical results based on quantile regressions suggest that the needs for achievement, belonging, and power are more important than others in predicting OC and JI. In addition, the basic ...

  16. Making Judges Independent – Some Proposals Regarding the Judiciary

    OpenAIRE

    Lars P. Feld; Stefan Voigt

    2004-01-01

    It is argued that an independent judiciary is a necessary condition for both individual liberty and economic prosperity. After having surveyed the literature dealing with how to arrange for an independent judiciary, the authors derive some additional policy implications by drawing on two indicators of judicial independence (JI) recently introduced by them. De facto JI has a robust and highly significant impact on economic growth. Individual components of both de jure and de facto JI on econom...

  17. Recent progress in experiment and theory of giant magnetoresistance in magnetic nanocontacts

    International Nuclear Information System (INIS)

    Tagirov, L. R.

    2005-01-01

    Full text: The experiment and theory of magnetoresistance (MR) in nanosize point contacts made of ferromagnetic metals is reviewed. The story begins from the series of experiments on Ni-Ni and Co-Co nanocontacts [1,2] in which an extraordinary high MR, 200-300%, has been observed at room temperature (see also the review [3] and references therein). Two basic mechanisms of nanosize contact MR have been proposed: enhancement of impurity scattering in the domain wall [2] and scattering of electrons by the geometrically constrained domain wall [4]. The theories were able to explain the values of magnetoresistance observed in the experiments. Very shortly afterwards further experiments raised the size of the effect till few thousand percents [5,6]. There was a discussion in the literature and scientific meetings that the observed giant MR was an artefact caused by the magneto-mechanical effect, but not true electronic MR. Indeed, some geometries of experiments could be doubted. However, a constructive development has been proposed by theory and carefully designed experiments. The theory predicted even higher magnetoresistance in the regime of conductance quantization through the magnetic nanocontact [7-10]. It seems that MR in conduction quantization regime has been observed in an experiment [11,12]. The work was supported by the RFBR grant No 03-02-17656. [1] N. Garcia, M. Munoz, and Y.-W. Zhao, Phys. Rev. Lett. 82, 2923 (1999). [2] G. Tatara, Y.-W. Zhao, M. Munoz, and N. Garcia, Phys. Rev. Lett. 83, 2030 (1999). [3] N. Garcia, M. Munoz, V.V. Osipov, et al., Journ. Magn. Magn. Mater. 240, 92-99 (2002). [4] L.R. Tagirov, B.P. Vodopyanov, K.B. Efetov, Phys. Rev. B 63, 104428 (2001). [5] H.D. Chopra, S.Z. Hua, Phys. Rev. B 66, 020403 (2002). [6] Hai Wang, H. Cheng, N. Garcia, cond-mat/0207516 (22 Jul 2002). [7] L.R. Tagirov, B.P. Vodopyanov, K.B. Efetov, Phys. Rev. B 65, 214419 (2002). [8] M.Ye. Zhuravlev, E.Y. Tsymbal, S.S. Jaswal et al., Appl. Phys. Lett. 83, 3534 (2003

  18. Stemcell Information: SKIP000587 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Yes Quantitative RT-PCR ... Yes ... Lei Ye Lei Ye Division of Cardiology,...Minnesota, United States of America ... Division of Cardiology, Department of Medici...ne, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardiology... Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Cardio...logy, Department of Medicine, University of Minnesota Medical School, Minneapolis,

  19. Stemcell Information: SKIP000585 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available istry Study Yes Cardiac Myocyte Differentiation ... No ... No ... Lei Ye Lei Ye Division of Cardiology...sota, United States of America Division of Cardiology, Department of Medicine, University of Minnesota Medic...al School, Minneapolis, Minnesota, United States of America Division of Cardiology...iology, Department of Medicine, University of Minnesota Medical School, Minneapolis..., Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ... Division of Card

  20. Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

    Directory of Open Access Journals (Sweden)

    Shi F

    2012-04-01

    Full Text Available Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaAbstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs for the oral delivery of frankincense and myrrh essential oils (FMO. Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP, and drug encapsulation efficiency (EE were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM. The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC and X-ray diffraction (XRD. In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of -16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.Keywords: solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicine

  1. In-situ Strontium Isotopes Analysis on Single Conodont Apatite by LA-MC-ICP-MS

    Science.gov (United States)

    Zhao, L.; Zhang, L.; Chen, Z. Q.; Ma, D.; Qiu, H.; Lv, Z.; Hu, Z.; Wang, F.

    2014-12-01

    Strontium isotope played an important role in stratigraphic chronology and sedimentary geochemistry research (McArthur et al., 2001). Conodonts is a kind of extinct species of marine animals and widely distributed in marine sediments all over the world. Rich in radiogenic Sr contents and difficulty to be affected during diagenesis alteration makes conodonts a good choice in seawater Sr isotope composition studies (John et al., 2008). Conodont samples were collected from 24th to 39th layer across Permian-Triassic boundary at Meishan D section (GSSP), Zhejiang Province, South China (Yin et al., 2001). Conodonts was originated from fresh limestone and only conodont elements with CAIextinction events during the Permian-Triassic transition. Our study also makes is possible for high resolution 87Sr/ 86Sr ratio testing on the single conodont apatite and riched the in-situ studies on the conodont apatite, which of great significance for the future conodont Sr isotope research (Zhao et al., 2009; Zhao et al., 2013). Keywords: Conodonts, Strontium isotope, LA-MC-ICP-MS, Permian-Triassic transition, Meishan D section [1] John et al., 2008 3P[2] McArthur et al., 2001 J. of Geology [3] Yin et al., 2001 Episodes [4] Zhao et al., 2009 Earth Science J. of CUG [5] Zhao et al., 2013 GPC.

  2. Research report of fiscal 1997. Basic research on joint implementation for preventing global climate changes; 1998 nendo chosa hokokusho. Kyodo jisshi kiso chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    Research was made to promote Activities Implemented Jointly Japan Program. Joint Implementation (JI) is the methodology for preventing global climate changes by collaboration of countries. The countries take cooperative actions for reduction, absorption and fixation of greenhouse gases, and effectively distribute the reduction credits among relevant parties. This was decided in the first session of the Conference of Parties (COP) held in March, 1995. In COP3, Japan`s assigned reduction amount in 2008-2012 was determined as 6% of the emission level in 1990. The protocol defines JI between parties as dealings of emission reduction units, and JI between developing countries as clean development mechanism. The rules for a base line and credit distribution are necessary before full-scale implementation. Although JI is regarded as an important cost-effective project, it is important to decide where and how the JI projects should been promoted. The present state and issues of the primary approved project of Japan Program are arranged. In particular, various terms related to developing countries remain to be solved. 21 figs., 32 tabs.

  3. Impact of Neutrino Flavor Oscillations on the Neutrino-driven Wind Nucleosynthesis of an Electron-capture Supernova

    Science.gov (United States)

    Pllumbi, Else; Tamborra, Irene; Wanajo, Shinya; Janka, Hans-Thomas; Hüdepohl, Lorenz

    2015-08-01

    Neutrino oscillations, especially to light sterile states, can affect nucleosynthesis yields because of their possible feedback effect on the electron fraction (Ye). For the first time, we perform nucleosynthesis calculations for neutrino-driven wind trajectories from the neutrino-cooling phase of an 8.8 {M}⊙ electron-capture supernova (SN), whose hydrodynamic evolution was computed in spherical symmetry with sophisticated neutrino transport and whose Ye evolution was post-processed by including neutrino oscillations between both active and active-sterile flavors. We also take into account the α-effect as well as weak magnetism and recoil corrections in the neutrino absorption and emission processes. We observe effects on the Ye evolution that depend in a subtle way on the relative radial positions of the sterile Mikheyev-Smirnov-Wolfenstein resonances, on collective flavor transformations, and on the formation of α particles. For the adopted SN progenitor, we find that neutrino oscillations, also to a sterile state with eV mass, do not significantly affect the element formation and in particular cannot make the post-explosion wind outflow neutron-rich enough to activate a strong r-process. Our conclusions become even more robust when, in order to mimic equation-of-state-dependent corrections due to nucleon potential effects in the dense-medium neutrino opacities, six cases with reduced Ye in the wind are considered. In these cases, despite the conversion of active neutrinos to sterile neutrinos, Ye increases or is not significantly lowered compared to the values obtained without oscillations and active flavor transformations. This is a consequence of a complicated interplay between sterile-neutrino production, neutrino-neutrino interactions, and α-effect.

  4. Yersinia enterocolitica and Photorhabdus asymbiotica β-lactamases BlaA are exported by the twin-arginine translocation pathway.

    Science.gov (United States)

    Schriefer, Eva-Maria; Hoffmann-Thoms, Stephanie; Schmid, Franz X; Schmid, Annika; Heesemann, Jürgen

    2013-01-01

    In general, β-lactamases of medically important Gram-negative bacteria are Sec-dependently translocated into the periplasm. In contrast, β-lactamases of Mycobacteria spp. (BlaC, BlaS) and the Gram-negative environmental bacteria Stenotrophomonas maltophilia (L2) and Xanthomonas campestris (Bla(XCC-1)) have been reported to be secreted by the twin-arginine translocation (Tat) system. Yersinia enterocolitica carries 2 distinct β-lactamase genes (blaA and blaB) encoding BlaA(Ye) and the AmpC-like β-lactamase BlaB, respectively. By using the software PRED-TAT for prediction and discrimination of Sec from Tat signal peptides, we identified a functional Tat signal sequence for Yersinia BlaA(Ye). The Tat-dependent translocation of BlaA(Ye) could be clearly demonstrated by using a Y. enterocolitica tatC-mutant and cell fractionation. Moreover, we could demonstrate a unique unusual temperature-dependent activity profile of BlaA(Ye) ranging from 15 to 60 °C and a high 'melting temperature' (T(M)=44.3°) in comparison to the related Sec-dependent β-lactamase TEM-1 (20-50°C, T(M)=34.9 °C). Strikingly, the blaA gene of Y. enterocolitica is present in diverse environmental Yersinia spp. and a blaA homolog gene could be identified in the closely related Photorhabdus asymbiotica (BlaA(Pa); 69% identity to BlaA(Ye)). For BlaA(Pa) of P. asymbiotica, we could also demonstrate Tat-dependent secretion. These results suggest that Yersinia BlaA-related β-lactamases may be the prototype of a large Tat-dependent β-lactamase family, which originated from environmental bacteria. Copyright © 2012 Elsevier GmbH. All rights reserved.

  5. International Assessment of Research and Development in Catalysis by Nanostructured Materials

    Science.gov (United States)

    2009-01-01

    can severely and irreversibly poison downstream catalysts, including those used in ammonia synthesis and proton exchange membrane fuel cells ( PEMFC ...membrane fuel cells ( PEMFC ), solid oxide fuel cells (SOFC), as well as molten carbonate, direct methanol, and direct carbon fuel cells. Much of the work...see site report, Appendix C) are developing methods to disperse Pt on Au cores for use in PEMFCs (Zhao, Wu, and Xu 2005; Zhao and Xu 2006). This

  6. Automatic Design of a Maglev Controller in State Space

    Science.gov (United States)

    1991-12-01

    Design of a Maglev Controller in State Space Feng Zhao Richard Thornton Abstract We describe the automatic synthesis of a global nonlinear controller for...the global switching points of the controller is presented. The synthesized control system can stabilize the maglev vehicle with large initial displace...NUMBERS Automation Desing of a Maglev Controller in State Space N00014-89-J-3202 MIP-9001651 6. AUTHOR(S) Feng Zhao and Richard Thornton 7. PERFORMING

  7. Enhancement of methyl tert-butyl ether degradation by the addition of readily metabolizable organic substrates

    International Nuclear Information System (INIS)

    Chen Dongzhi; Chen Jianmeng; Zhong Weihong

    2009-01-01

    Supplements with readily metabolizable organic substrates were investigated to increase the biomass and enhance degradation of methyl tert-butyl ether (MTBE) due to the low biomass yield of MTBE which has been one of the factors for low-rate MTBE degradation. The influence of various organic substrates on the rate of aerobic degradation of methyl tert-butyl ether (MTBE) by Methylibium petroleiphilum PM1 was investigated, and only yeast extract (YE), beef extract and tryptone exhibited stimulatory effect. With the concentration of each substrate being 100 mg/L, the average MTBE removal rate could increase to 1.29, 1.20 and 1.04 mg/(L h), respectively, in comparison with 0.71 mg/(L h) when carried out in medium without addition. The stimulatory effects of YE addition, as well as induction period required by MTBE degradation, varied dramatically with the storage conditions, pre-culture medium and concentrations of the inoculums. The extent of stimulatory effects of YE might be closely related to the proportion of induction period in the total time of MTBE-degradation. The removal efficiency increased from about 50% to 90.5% with the addition of YE in a packed-bed reactor loaded with calcium alginate immobilized cells.

  8. Effects on grape amino acid concentration through foliar application of three different elicitors.

    Science.gov (United States)

    Gutiérrez-Gamboa, G; Portu, J; Santamaría, P; López, R; Garde-Cerdán, T

    2017-09-01

    Elicitors play an important role in the defense against pathogens as an alternative to chemical pesticides by increasing secondary metabolites. Their effect on grape amino acid has been little investigated. Thus, the aim of this research was to study the influence of methyl jasmonate (MeJ), chitosan (CHT), and a yeast extract (YE) on grape amino acid composition, through foliar applications to grapevines. The must amino acid concentration was analyzed by HPLC. The results showed that CHT and YE treatments decreased the must concentration of several amino acids, affecting total amino acid content (from 2364 to 1961, and 1818mg/L, respectively). However, MeJ treatment had a slight effect on grape amino acid content, increasing the concentration of Met (from 8.95 to 12.13mg/L) and Phe (from 7.96 to 9.29mg/L). It seems to be that, the resistance induction through CHT and YE treatments results in physiological costs to grapevines associated with a decrease on grape amino acid concentration. Consequently, MeJ applications, as a viticultural practice, could be a better tool than CHT and YE treatments, because did not affect grape amino acid concentration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Studi Pemanfaatan Jantung Pisang dan Ikan Gabus dalam Pembuatan Nugget

    OpenAIRE

    Pratiwi, Lisma; ', Yusmarini; Harun, Noviar

    2016-01-01

    The purpose of research is to identify the ratio influence of the banana's heart and the gabus fish concerning the result of nugget quality and the best formulation in making process of the banana's heart and the gabus fish nugget. This research was carried out experimentally by using Completely Randomized Design consisting of 5 treatments with 3 replications. The treatments consist of JI1 = (banana's heart 10 : gabus fish 90), JI2 = (banana's heart 15 : gabus fish 85), JI3 = (banana's heart ...

  10. Factor X assay

    Science.gov (United States)

    ... Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice . ... Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice . ...

  11. Thrombocytopenia

    Science.gov (United States)

    ... Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice . ... Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice . ...

  12. Bibliography of Soviet Laser Developments Number 54, July-August 1981.

    Science.gov (United States)

    1982-12-01

    as a continuing effort to document current Soviet-bloc developments in the quantum electronics field. The period covered is July-August 1981, and...Theory 20. Gershenzon, Ye.M., V.M. Kalygina, B.I. Levit , and B.N. Tumanov (464). Relaxation ogcillation resonance in autodyne oscillators. IVUZ...7Ye446) 189. Stapor, A., 3. Langer, T. Langer, and B. Krukowska-Fulde(NS). Efficient two- and three- quantum conversion of IR radiation to the visible in

  13. Tlhalošontši ya mongwalo: Go ngwala seo se sa tšweletšego ...

    African Journals Online (AJOL)

    Bontši bja baithuti ba maleme a Bathobaso ga bo tšee mongwalo go ba ye nngwe ya dithutwana tše bohlokwa tša maleme. Ka fao barutwana le batho ba bangwe ba go kgona go bala le go ngwala ga ba sa na le taba le thutwana ye ya mongwalo. Seo se dira gore go be le mabošaedi a mmalwa go akaretšwa a mopeleto, ...

  14. PREFACE International Symposium on Spintronic Devices and Commercialization 2010

    Science.gov (United States)

    Du, You-wei; Judy, Jack; Qian, Zhenghong; Wang, Jianping

    2011-01-01

    very successful indeed. We are also grateful to the Advisory Committee, the Conference Chairs, the Excutive Chairs, the Academic Committee, the Organization Committee and the Secretariat for their fruitful work. We would especially like to thank all the organizers listed below for their support in all aspects of the conference. We would like to express our thanks to all the authors for their time and genuine efforts, and to the reviewers for their fruitful comments during the preparation of this volume. ISSDC'2010 ORGANIZATION Advisory Committee Chialing Chien, USAJunhao Chu, ChinaBernard Dieny, FranceKoichiro Inomata, Japan Liangmo Mei, ChinaJohn Sivertsen, USAMingjing Tu, ChinaDingsheng Wang, China Zhanguo Wang, ChinaQikun Xue, ChinaWenshan Zhan, China Conference Chairs Jack Judy, USAYouwei Du, China Executive Chairs Zhenghong Qian, USAJianping Wang, USA Organization Committee ChairJiyan Luo, China Vice ChairsGuilin Duan, ChinaLingling Sun, ChinaBaogen Shen, China MembersTiecheng Lu, ChinaDa Ma, ChinaYe Tian, China Jinsong Xu, ChinaQiuling XuChangmao Yang, China Guanghua Yu, ChinaYi Yan, China Academic Committee ChairsZhenghong Qian, USAYongbing Xu, UK Vice ChairsSeongtae Bae, SingaporeYong Jiang, ChinaDexin Wang, USA Huaiwu Zhang, ChinaJianhua Zhao, China MembersJianwang Cai, ChinaXiangdong Chen, ChinaHaifeng Ding, China Chunhong Hou, USAGunther Baubock, USABin Hu, USA Jungchun Huang, TaiwanDexuan Huo, ChinaYoon H Jeong, Korea Chihuang Lai, TaiwanRunwei Li, ChinaWei Liu, China Jing Shi, USAYasushi Takemura, JapanMark Tondra, USA Shan X Wang, USADi Wu, ChinaDesheng Xue, China Minglang Yan, USAShishen Yan, ChinaXiaofei Yang, China Chun Yeol You, KoreaWei Zhao, ChinaShiming Zhou, China Jianguo Zhu, China Secretariat Secretary-generalChangmao Yang, China Vice Secretary-generalJunli Wang, ChinaJinsong Xu, ChinaYe Tian, China MembersRu Bai, ChinaHongliang Zhan, China ISSDC' 2010 Organizers Department of Science and Technology, CSIC, China SpinIC Inc., China Hangzhou

  15. Genetics Home Reference: IRAK-4 deficiency

    Science.gov (United States)

    ... Blanco JC, Salkowski C, Zhang S, Arditi M, Gallin JI, Vogel SN. Distinct mutations in IRAK-4 confer ... Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino ...

  16. Fungi detoxification study from pistachio by non-ionizing irradiation; Barrasi-ye estefadeh az parto'ha-ye gheyr-e yonsaz dar gharchzoda-i-ye pesteh

    Energy Technology Data Exchange (ETDEWEB)

    Ghafourian, H; Sadighzadeh, A; Dabbagh, R

    1998-07-01

    4,6 and 10 minutes of microwaves exposure provides and effective and relatively rapid sterilization for different purposes in medicine and food industries for example sterilization of materials which have been contaminated with Aspergillus flavus (Pcc-5004) and Aspergillus parasiticus (Pcc-5018) which are producer of Aflatoxin especially on pistachios and other dried fruits. Microwaves exposure induces a morphological modification of the cells and germicidal effects of ultrasonic waves has been attributed to gaseous cavitation. There was a significant reduction in fungal growth compared with those under the control which decreased growth with increased microwave and ultrasound exposure time.

  17. Japan's healthcare policy for the elderly through the concepts of self-help (Ji-jo), mutual aid (Go-jo), social solidarity care (Kyo-jo), and governmental care (Ko-jo).

    Science.gov (United States)

    Sudo, Kyoko; Kobayashi, Jun; Noda, Shinichiro; Fukuda, Yoshiharu; Takahashi, Kenzo

    2018-03-18

    Elderly care is an emerging global issue threatening both developed and developing countries. The elderly in Japan increased to 26.7% of the population in 2015, and Japan is classified as a super-aged society. In this article, we introduce the financial aspects of the medical care and welfare services policy for the elderly in Japan. Japan's universal health insurance coverage system has been in place since 1961. Long-term care includes welfare services, which were separated from the medical care insurance scheme in 2000 when Japan was already recognized as an aging society. Since then, the percentage of the population over 65 has increased dramatically, with the productive-age population on the decrease. The Japanese government, therefore, is seeking to implement "The Community-based Integrated Care System" with the aim of building comprehensive up-to-the-end-of-life support services in each community. The system has four proposed elements: self-help (Ji-jo), mutual aid (Go-jo), social solidarity care (Kyo-jo), and government care (Ko-jo). From the financial perspective, as the government struggles against the financial burdens of an aging population, they are considering self-help and mutual aid. Based on Japan's present situation, both elements could lead to positive results. The Japanese government must also entrust the responsibility for implementing preventive support to municipalities through strongly required regional autonomy. As Japan has resolved this new challenge through several discussions over a long period of time, other aging countries could learn from the Japanese experience of solving barriers to healthcare policy for the elderly.

  18. Effect of Zhen-wu decoction on chronic heart failure in rats

    African Journals Online (AJOL)

    ... has been an increased hospitalization burden, and makes HF a global public health problem. The most effective and commonly used drugs for treatment of HF are angiotensin-converting enzyme (ACE) inhibitors, β-adrenoceptor blockers, and digitalis [5-7]. The American Heart. Association (AHA) and European Society of ...

  19. Joint implementation: methodology and policy considerations

    International Nuclear Information System (INIS)

    Illum, Klaus; Meyer, N.I.

    2004-01-01

    The focus of the present paper is on joint implementation (JI) projects between countries in Western and Eastern Europe and especially on the problems of constructing credible references (baselines). A number of the present EU countries are anticipated to have severe problems in meeting their greenhouse gas reduction commitments and they have already announced that they shall take advantage of JI in this connection. As stated in the Kyoto Protocol, JI emission reductions must be real and measurable. However, in most cases the reductions obtained by a JI project do not occur at the project site but elsewhere in the energy system. Therefore, when a number of JI projects are implemented concurrently and other changes in the energy system take place over time, there is no way to measure the reductions obtained by individual projects. Because the emission reduction obtained is a property of the entire energy system, it cannot be estimated a priori on the basis of a project baseline alone. A baseline must refer to the national energy system of which the project is a part. It is argued in this paper that baselines should be derived from national energy systems databases and models, which serve to ensure that JI projects effectively contribute to the fulfillment of the Kyoto Protocol objectives. In addition, they should provide governments with comprehensive energy information systems needed to address long-term climate mitigation and energy demand and supply issues in a rational, least-cost manner. Compared to other climate mitigation costs and the costs of failure to meet the Kyoto commitments the costs involved in the preparation of the databases needed and the implementation of systems analysis and documentation programs will be small. If these costs are carried by national governments, the investors in JI projects will benefit from lower transaction costs

  20. Adding to Yersinia enterocolitica Gene Pool Diversity: Two Cryptic Plasmids from a Biotype 1A Isolate

    Directory of Open Access Journals (Sweden)

    Daniela Lepka

    2009-01-01

    Full Text Available We report the nucleotide sequence of two novel cryptic plasmids (4357 and 14 662 base pairs carried by a Yersinia enterocolitica biotype 1A strain isolated from pork. As distinguished from most biotype 1A strains, this isolate, designated 07-04449, exhibited adherence to eukaryotic cells. The smaller plasmid pYe4449-1 carries five attributable open reading frames (ORFs encoding the first CcdA/CcdB-like antitoxin/toxin system described for a Yersinia plasmid, a RepA-like replication initiation protein, and mobilizing factors MobA and MobC. The deduced amino acid sequences showed highest similarity to proteins described in Salmonella (CcdA/B, Klebsiella (RepA, and Plesiomonas (MobA/C indicating genomic fluidity among members of the Enterobacteriaceae. One additional ORF with unknown function, termed ORF5, was identified with an ancestry distinct from the rest of the plasmid. While the C+G content of ORF5 is 38.3%, the rest of pYe4449-1 shows a C+G content of 55.7%. The C+G content of the larger plasmid pYe4449-2 (54.9% was similar to that of pYe4449-1 (53.7% and differed from that of the Y. enterocolitica genome (47.3%. Of the 14 ORFs identified on pYe4449-2, only six ORFs showed significant similarity to database entries. For three of these ORFs likely functions could be ascribed: a TnpR-like resolvase and a phage replication protein, localized each on a low C+G island, and DNA primase TraC. Two ORFs of pYe4449-2, ORF3 and ORF7, seem to encode secretable proteins. Epitope-tagging of ORF3 revealed protein expression at 4°C but not at or above 27°C suggesting adaptation to a habitat outside swine. The hypothetical protein encoded by ORF7 is the member of a novel repeat protein family sharing the DxxGN(xnDxxGN motif. Our findings illustrate the exceptional gene pool diversity within the species Y. enterocolitica driven by horizontal gene transfer events.

  1. The rich get richer and the poor get poorer: Country- and state-level income inequality moderates the job insecurity-burnout relationship.

    Science.gov (United States)

    Jiang, Lixin; Probst, Tahira M

    2017-04-01

    Despite the prevalence of income inequality in today's society, research on the implications of income inequality for organizational research is scant. This study takes the first step to explore the contextual role of national- and state- level income inequality as a moderator in the relationship between individual-level job insecurity (JI) and burnout. Drawing from conservation of resource (COR) theory, we argue that income inequality at the country-level and state-level threatens one's obtainment of object (i.e., material coping) and condition (i.e., nonmaterial coping) resources, thus serving as an environmental stressor exacerbating one's burnout reactions to JI. The predicted cross-level interaction effect of income inequality was tested in 2 studies. Study 1 consisting of 23,778 individuals nested in 30 countries explored the moderating effect of country-level income inequality on the relationship between individual JI and exhaustion. Study 2 collected data from 402 employees residing in 48 states in the United States, and tested the moderating effect of state-level income inequality on the relationship between JI and burnout (i.e., emotional exhaustion and cynicism). Results of both studies converge to support the exacerbating role of higher-level income inequality on the JI -burnout relationship. Our findings contribute to the literature on psychological health disparities by exploring the contextual role of income inequality as a predictor of differential reactions to JI. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  2. Synthesis and characterization of superparamagnetic polymeric nanocapsules

    Energy Technology Data Exchange (ETDEWEB)

    Grillo, Renato; Fraceto, Leonardo Fernandes, E-mail: renato.grillo@ymail.com [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Sorocaba, SP (Brazil); Gallo, Juan; Grando Stroppa, Daniel; Carbo-Argibay, Enrique; Banõbre-Lopez, Manuel [International Iberian Nanotechnology Laboratory, Braga (Portugal); Lima, Renata de [Universidade de Sorocaba (UNISO), SP (Brazil)

    2016-07-01

    Full text: A wide variety of applications have been considered for superparamagnetic iron oxide nanoparticles (SPIONs), such as magnetic resonance imaging, cancer therapy and remediation of contaminants [1].Polymeric nanostructures (PNS) have also received great interest as suitable encapsulating agents and carriers due to their ability to influence the delivery profile. Hybrid nanosystems have been explored as a synergic approach that combines the modified active release induced by the polymer encapsulation and the intrinsic properties from the inorganic nanoparticles [2]. In this context, poly-ε-caprolactone nanocapsules containing different concentration of ∼8 nm superparamagnetic oleic acid coated magnetite (Fe{sub 3}O{sub 4}@OA) nanoparticles were developed. Successful incorporation of the magnetic nanoparticles was confirmed by transmission electron microscopy coupled with energy dispersive X-ray (TEM-EDX). Results showed that they accumulate preferentially in the outer organic membrane of the PNS. On the other hand, scanning electron microscopy and dynamic light scattering measurements showed a significant increase in particle size from ca. 400 to 800 nm. Magnetic measurements as a function of the applied magnetic field and temperature were performed in both vibrant sample (VSM) and superconducting quantum interference device magnetometers (SQUID). Hysteresis loops showed a superparamagnetic behavior with increasing saturation magnetization as magnetite concentration was progressively incorporated into the PNS. Zero-field cooled and field-cooled (ZFC-FC) magnetic curves showed a shift of the blocking temperature to higher temperatures as the content of magnetite increases in the capsules. These results are promising and contribute to a better understanding of the interaction between magnetic nanoparticles and PNS. References: [1] L. Zhang, W. Dong, H. Sun. Nanoscale 5, 7664-7684 (2013) [2] K.T. Nguyen and Y.L. Zhao. Acc. Chem. Res. 48, 3016-3025 (2015

  3. Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

    Directory of Open Access Journals (Sweden)

    Xie L

    2016-11-01

    Full Text Available Lisha Xie,1,* Tiancen Zhao,1,2,* Jing Cai,1 You Su,1 Zehua Wang,1 Weihong Dong1 1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2Department of Obstetrics and Gynecology, Central Hospital of Wuhan, Wuhan, China *These authors contributed equally to this work Objective: The objective of this study was to investigate the mechanism of sensitivity to methotrexate (MTX in human choriocarcinoma cells regarding DNA damage response. Methods: Two choriocarcinoma cancer cell lines, JAR and JEG-3, were utilized in this study. An MTX-sensitive osteosarcoma cell line MG63, an MTX-resistant epithelial ovarian cancer cell line A2780 and an MTX-resistant cervical adenocarcinoma cell line Hela served as controls. Cell viability assay was carried out to assess MTX sensitivity of cell lines. MTX-induced DNA damage was evaluated by comet assay. Quantitative reverse transcription polymerase chain reaction was used to detect the mRNA levels of BRCA1, BRCA2, RAD51 and RAD52. The protein levels of γH2AX, RAD 51 and p53 were analyzed by Western blot. Results: Remarkable DNA strand breaks were observed in MTX-sensitive cell lines (JAR, JEG-3 and MG63 but not in MTX-resistant cancer cells (A2780 and Hela after 48 h of MTX treatment. Only in the choriocarcinoma cells, the expression of homologous recombination (HR repair gene RAD51 was dramatically suppressed by MTX in a dose- and time-dependent manner, accompanied with the increase in p53. Conclusion: The MTX-induced DNA strand breaks accompanied by deficiencies in HR repair may contribute to the hypersensitivity to chemotherapy in choriocarcinoma. Keywords: choriocarcinoma, chemotherapy hypersensitivity, DNA double-strand break, RAD51, p53

  4. Gold nanorod–based poly(lactic-co-glycolic acid with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

    Directory of Open Access Journals (Sweden)

    Wang L

    2017-04-01

    Full Text Available Lei Wang,1–3 Dong Li,1,2 Yongwei Hao,1,2 Mengya Niu,1,2 Yujie Hu,1,2 Hongjuan Zhao,1,2 Junbiao Chang,2,3 Zhenzhong Zhang,1,2 Yun Zhang1,2 1School of Pharmaceutical Sciences, Zhengzhou University, 2Key Laboratory of Targeting Therapy and Diagnosis for Critical Disease, Henan Province, 3School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, People’s Republic of China Abstract: Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid (PLGA nanoparticles (NPs loaded with AuNRs and docetaxel (DTX (PLGA/AuNR/DTX NPs were constructed. Finally, manganese dioxide (MnO2 ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO4 to construct the PLGA/AuNR/DTX@MnO2 drug delivery system. This drug delivery system can not only be used for the combined therapy of chemotherapy and RF hyperthermia but can also produce Mn2+ to enable magnetic resonance imaging. Furthermore, the RF hyperthermia and the degradation of MnO2 can significantly promote the controlled drug release in a tumor region. The in vitro and in vivo results suggested that the PLGA/AuNR/DTX@MnO2 multifunctional drug delivery system is a promising nanoplatform for effective cancer theranostic applications. Keywords: poly(lactic-co-glycolic acid, gold nanorod, manganese dioxide, radiofrequency, hyperthermia, dual-mode imaging, controlled release

  5. Increased fibroblast functionality on CNN2-loaded titania nanotubes

    Directory of Open Access Journals (Sweden)

    Wei HB

    2012-02-01

    Full Text Available Hongbo Wei*, Shuyi Wu*, Zhihong Feng, Wei Zhou, Yan Dong, Guofeng Wu, Shizhu Bai, Yimin Zhao Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, People's Republic of China *These authors contributed equally to this workAbstract: Infection and epithelial downgrowth are major problems associated with maxillofacial percutaneous implants. These complications are mainly due to the improper closure of the implant–skin interface. Therefore, designing a percutaneous implant that better promotes the formation of a stable soft tissue biologic seal around percutaneous sites is highly desirable. Additionally, the fibroblast has been proven to play an important role in the formation of biologic seals. In this study, titania nanotubes were filled with 11.2 kDa C-terminal CCN2 (connective tissue growth factor fragment, which could exert full CCN2 activity to increase the biological functionality of fibroblasts. This drug delivery system was fabricated on a titanium implant surface. CCN2 was loaded into anodized titania nanotubes using a simplified lyophilization method and the loading efficiency was approximately 80%. Then, the release kinetics of CCN2 from these nanotubes was investigated. Furthermore, the influence of CCN2-loaded titania nanotubes on fibroblast functionality was examined. The results revealed increased fibroblast adhesion at 0.25, 0.5, 1, 2, 4, and 24 hours, increased fibroblast viability over the course of 5 days, as well as enhanced actin cytoskeleton organization on CCN2-loaded titania nanotubes surfaces compared to uncoated, unmodified counterparts. Therefore, the results from this in vitro study demonstrate that CCN2-loaded titania nanotubes have the ability to increase fibroblast functionality and should be further studied as a method of promoting the formation of a stable soft tissue biologic seal around percutaneous sites.Keywords: anodization, titania nanotubes, adhesion, connective

  6. Lack of association between the XPD Lys751Gln polymorphism and colorectal cancer risk: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Zhang T

    2014-07-01

    Full Text Available Tao Zhang,1,* Dong-ming Zhang,2,* Da Zhao,1 Xiao-ming Hou,1 Shou-cheng Ma,1 Xiao-jun Liu1 1Department of Oncology, The First Hospital of Lanzhou University, The Branch Hospital of Donggang, Lanzhou, 2Department of Oncology, The Second People's Hospital of Pingliang, Pingliang, People's Republic of China  *These authors contributed equally to this work Background: The xeroderma pigmentosum complementary group D (XPD gene has been linked to the development of colorectal cancer (CRC through disruption of DNA repair. Several studies have suggested that the XPD polymorphism Lys751Gln is associated with an increased risk of developing CRC. However, previous results remain inconclusive. Herein, we performed a meta-analysis to evaluate the potential for this relationship. Methods: Relevant studies were retrieved from the PubMed database. Strict selection and exclusion criteria were determined, and the odds ratio with a 95% confidence interval was used to assess the strength of associations. The fixed or random effects model was selected on the basis of heterogeneity tests among studies. Publication bias was estimated using funnel plots and Egger's regression test. Results: The meta-analysis included 2,961 cases and 4,539 controls from eleven studies. The results indicated that the XPD Lys751Gln polymorphism had no association with CRC risk for all genetic models (Gln-Gln versus Lys-Lys, P=0.477; Lys-Gln versus Lys-Lys, P=0.283; Lys-Gln + Gln-Gln versus Lys-Lys, P=0.562, even when compared within subgroups based on ethnicity and source of controls. Conclusion: Based on the results of our meta-analysis, there is no evidence of a link between the XPD Lys751Gln polymorphism and risk of CRC. Keywords: XPD Lys751Gln polymorphism, colorectal cancer risk, meta-analysis

  7. Genetics Home Reference: 3-beta-hydroxysteroid dehydrogenase deficiency

    Science.gov (United States)

    ... for This Page Lutfallah C, Wang W, Mason JI, Chang YT, Haider A, Rich B, Castro-Magana ... A, Copeland KC, Chang YT, Lutfallah C, Mason JI. Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) ...

  8. 2790-IJBCS-Article-Lambienou YE

    African Journals Online (AJOL)

    hp

    Cette étude a porté sur les sols et la végétation herbacée d'une savane pâturée au Burkina Faso. Elle ... does not impact soil chemical and biological parameters, except for soil basal respiration that increases .... Hyparrhenia subplumosa,.

  9. JPRS Report, Science & Technology, USSR: Science & Technology Policy

    Science.gov (United States)

    1990-05-31

    information science, and found money for a children’s rehabilitation center and a children’s outpa- tient clinic; it purchased medicines for the victims...Yu.V. Muravyev, S.K. Sokolov, A.P. Alyabyev. "The Development of New Methods and Systems of the Therapy of Rheumatic Diseases." Recommended by...Institute of Irrigated Horticulture . 24. Ye.A. Osipova, M.P. Mingova, G.A. Loginova, Ye.S. Sharova, V.V. Prilepov. "The Development of the Nevskiy

  10. Quantitative trait locus (QTL) mapping for 100-kernel weight of ...

    African Journals Online (AJOL)

    hope&shola

    2010-12-06

    Dec 6, 2010 ... regimes. Xiao-Hong Liu1, Zu-Ping Zheng2*, Zhen-Bo Tan3, Zhong Li2 and Chuan He2 ... al., 2005; Liu et al., 2007; Wang et al., 2007a; Guo et al.,. 2008; Tang .... They could individually account for 12.63, 7.22, 4.47 and 14.47% of .... Liu ZH, Tang JH, Wei XY, Wang EL, Tian GW, Hu YM, Chen WC. (2007).

  11. Mutation and screening of high-alcoholic-yield yeast by HEPE and optimization of the fermentation condition

    International Nuclear Information System (INIS)

    Han Jingjing; Lu Jiangtao; Zhang Qin; Wang Yan; Fu Yujie; Wang Shilong; Fu Haiying

    2011-01-01

    The Saccharomyces Cerevisiae YE0 was mutated using high-energy-pulse-electron (HEPE) beam. After ethanol stress and determination of the alcohol yield by gas chromatograph, the mutant YF1 with high alcoholic yield was obtained. The results showed that under the optimized fermentation conditions (34 degree C as the fermentation temperature, 72 h as the fermentation time and 30% as the glucose concentration), the alcoholic yield of YF1 was 15.57% which was 58.23% higher than that of the original strain YE0 (9.84%) under the same conditions. The growth rate and lethal temperature of the mutant YF1 were obviously enhanced to the original strain YE0. The mutant YF1 has a great potential application in industrial production of alcohol. And it can also be used as the original strain for further mutagenesis to get the strain of higher alcoholic yield. (authors)

  12. Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil: formulation and pharmacokinetics

    Directory of Open Access Journals (Sweden)

    Ma S

    2013-10-01

    Full Text Available Shilin Ma,1 Fen Chen,1 Xiaohui Ye,2 Yingjie Dong,2 Yingna Xue,1 Heming Xu,1 Wenji Zhang,1 Shuangshuang Song,1 Li Ai,2 Naixian Zhang,2 Weisan Pan1 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2Liaoning Institute of Pharmaceutical Industry, Liaoning, The People's Republic of China Abstract: The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain triglyceride, soybean lecithin, Solutol®HS 15, PEG 400, and water was developed for docetaxel intravenous administration. A formulation with higher drug content, lower viscosity, and smaller particle size was developed. The droplet size distribution of the dispersed phase of the optimized microemulsion was 13.5 nm, determined using a dynamic light scattering technique. The small droplet size enabled the microemulsion droplets to escape from uptake and phagocytosis by the reticuloendothelial system and increased the circulation time of the drug. The zeta potential was -41.3 mV. The optimized microemulsion was pale yellow, transparent, and non-opalescent in appearance. The value of the combination index was 0.58, showing that there was a synergistic effect when docetaxel was combined with Brucea javanica oil. After a single intravenous infusion dose (10 mg/kg in male Sprague Dawley rats, the area under the curve of the microemulsion was higher and the half-time was longer compared with that of docetaxel solution alone, and showed superior pharmacokinetic characteristics. These results indicate that this preparation of docetaxel in emulsion is likely to provide an excellent prospect for clinical tumor treatment. Keywords: microemulsion, docetaxel

  13. Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1

    Directory of Open Access Journals (Sweden)

    Dong L

    2015-12-01

    Full Text Available Liwei Dong,1 Hongge Wang,1 Jiajing Niu,1 Mingwei Zou,2 Nuoting Wu,1 Debin Yu,1 Ye Wang,1 Zhihua Zou11Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China; 2Department of Psychology, College of Liberal Arts and Social Sciences, University of Houston, Houston, TX, USA Abstract: Inhibition of the nucleotide pool sanitizing enzyme MTH1 causes extensive oxidative DNA damages and apoptosis in cancer cells and hence may be used as an anticancer strategy. As natural products have been a rich source of medicinal chemicals, in the present study, we used the MTH1-catalyzed enzymatic reaction as a high-throughput in vitro screening assay to search for natural compounds capable of inhibiting MTH1. Echinacoside, a compound derived from the medicinal plants Cistanche and Echinacea, effectively inhibited the catalytic activity of MTH1 in an in vitro assay. Treatment of various human cancer cell lines with Echinacoside resulted in a significant increase in the cellular level of oxidized guanine (8-oxoguanine, while cellular reactive oxygen species level remained unchanged, indicating that Echinacoside also inhibited the activity of cellular MTH1. Consequently, Echinacoside treatment induced an immediate and dramatic increase in DNA damage markers and upregulation of the G1/S-CDK inhibitor p21, which were followed by marked apoptotic cell death and cell cycle arrest in cancer but not in noncancer cells. Taken together, these studies identified a natural compound as an MTH1 inhibitor and suggest that natural products can be an important source of anticancer agents. Keywords: Echinacoside, MTH1, 8-oxoG, DNA damage, apoptosis, cell cycle arrest

  14. Joint implementation along two ways

    International Nuclear Information System (INIS)

    De Vos, R.

    1997-01-01

    In the test phase to the year 2000 joint implementation (JI) must prove to be a valuable tool for the climate change policy. The Dutch Ministries of Housing, Planning and Environmental Protection (VROM) and Economic Affairs (EZ) would like to form a basis for a JI-protocol during the Climate Conference in Kyoto, Japan, which will be held at the end of 1997. However, the Ministry of Development Cooperation wants to follow a more careful approach towards the cooperation with developing countries. Special attention is paid to a JI-project in Romania

  15. Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis.

    Directory of Open Access Journals (Sweden)

    Stella E Autenrieth

    2012-02-01

    Full Text Available Dendritic cells (DCs as professional antigen-presenting cells play an important role in the initiation and modulation of the adaptive immune response. However, their role in the innate immune response against bacterial infections is not completely defined. Here we have analyzed the role of DCs and their impact on the innate anti-bacterial host defense in an experimental infection model of Yersinia enterocolitica (Ye. We used CD11c-diphtheria toxin (DT mice to deplete DCs prior to severe infection with Ye. DC depletion significantly increased animal survival after Ye infection. The bacterial load in the spleen of DC-depleted mice was significantly lower than that of control mice throughout the infection. DC depletion was accompanied by an increase in the serum levels of CXCL1, G-CSF, IL-1α, and CCL2 and an increase in the numbers of splenic phagocytes. Functionally, splenocytes from DC-depleted mice exhibited an increased bacterial killing capacity compared to splenocytes from control mice. Cellular studies further showed that this was due to an increased production of reactive oxygen species (ROS by neutrophils. Adoptive transfer of neutrophils from DC-depleted mice into control mice prior to Ye infection reduced the bacterial load to the level of Ye-infected DC-depleted mice, suggesting that the increased number of phagocytes with additional ROS production account for the decreased bacterial load. Furthermore, after incubation with serum from DC-depleted mice splenocytes from control mice increased their bacterial killing capacity, most likely due to enhanced ROS production by neutrophils, indicating that serum factors from DC-depleted mice account for this effect. In summary, we could show that DC depletion triggers phagocyte accumulation in the spleen and enhances their anti-bacterial killing capacity upon bacterial infection.

  16. Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y.

    Science.gov (United States)

    Nishida, Yuichiro; Adati, Naoki; Ozawa, Ritsuko; Maeda, Aasami; Sakaki, Yoshiyuki; Takeda, Tadayuki

    2008-10-28

    SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signalling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is unclear. To investigate this mechanism, we compared the gene expression profiles in SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E), each of which show a different phenotype during RA-mediated differentiation. SH-SY5Y-A cells differentiated in the presence of RA, whereas RA-treated SH-SY5Y-E cells required additional treatment with brain-derived neurotrophic factor (BDNF) for full differentiation. After exposing cells to a PI3K inhibitor, LY294002, we identified 386 genes and categorised these genes into two clusters dependent on the PI3K signalling pathway during RA-mediated differentiation in SH-SY5Y-A cells. Transcriptional regulation of the gene cluster, including 158 neural genes, was greatly reduced in SK-N-SH cells and partially impaired in SH-SY5Y-E cells, which is consistent with a defect in the neuronal phenotype of these cells. Additional stimulation with BDNF induced a set of neural genes that were down-regulated in RA-treated SH-SY5Y-E cells but were abundant in differentiated SH-SY5Y-A cells. We identified gene clusters controlled by PI3K- and TRKB-mediated signalling pathways during the differentiation of two subtypes of SH-SY5Y cells. The TRKB-mediated bypass pathway compensates for impaired neural function generated by defects in several signalling pathways, including PI3K in SH-SY5Y-E cells. Our expression profiling data will be useful for further elucidation of the signal transduction-transcriptional network involving PI3K or TRKB.

  17. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model.

    Directory of Open Access Journals (Sweden)

    Martin Köberle

    2009-08-01

    Full Text Available Yersinia enterocolitica (Ye evades the immune system of the host by injection of Yersinia outer proteins (Yops via a type three secretion system into host cells. In this study, a reporter system comprising a YopE-beta-lactamase hybrid protein and a fluorescent staining sensitive to beta-lactamase cleavage was used to track Yop injection in cell culture and in an experimental Ye mouse infection model. Experiments with GD25, GD25-beta1A, and HeLa cells demonstrated that beta1-integrins and RhoGTPases play a role for Yop injection. As demonstrated by infection of splenocyte suspensions in vitro, injection of Yops appears to occur randomly into all types of leukocytes. In contrast, upon infection of mice, Yop injection was detected in 13% of F4/80(+, 11% of CD11c(+, 7% of CD49b(+, 5% of Gr1(+ cells, 2.3% of CD19(+, and 2.6% of CD3(+ cells. Taking the different abundance of these cell types in the spleen into account, the highest total number of Yop-injected cells represents B cells, particularly CD19(+CD21(+CD23(+ follicular B cells, followed by neutrophils, dendritic cells, and macrophages, suggesting a distinct cellular tropism of Ye. Yop-injected B cells displayed a significantly increased expression of CD69 compared to non-Yop-injected B cells, indicating activation of these cells by Ye. Infection of IFN-gammaR (receptor- and TNFRp55-deficient mice resulted in increased numbers of Yop-injected spleen cells for yet unknown reasons. The YopE-beta-lactamase hybrid protein reporter system provides new insights into the modulation of host cell and immune responses by Ye Yops.

  18. The Lao Dong Party of North Vietnam

    Science.gov (United States)

    1960-06-17

    and consol- idation of the cooperative movement and with the achievement of the task of reforming democracy in the mountain regions. .. . During the...that, on the overall picture of the enlarged cooperative movement , we must continue to improve the degree of enlightenment about socialism of the

  19. USO DA ANÁLISE ESPACIAL PARA AVALIAÇÃO DE INDICADORES DE QUALIDADE DO LEITE NA MICRO-REGIÃO DE JI-PARANÁ, RONDÔNIA, 2011 Use of spatial analys for milk quality indicators evaluation from micro-region of Ji-Paraná, Rondônia, 2011

    Directory of Open Access Journals (Sweden)

    Gilvânia Lúcia de Oliveira Carvalho

    2014-06-01

    Full Text Available Os atributos geográficos relacionados à localização dos rebanhos e seus indicadores de qualidade do leite podem ser explorados em termos geoestatísticos para análise e identificação de áreas (territórios com características geográficas semelhantes e providas de correlação espacial para variáveis de interesse. O objetivo do presente estudo foi analisar a viabilidade da análise espacial para avaliação de indicadores de qualidade do leite. O trabalho foi desenvolvido com informações sobre as coordenadas geográficas, teores de gordura, proteína, lactose, contagem de células somáticas (CCS e contagem total de bactérias (CTB de 217 rebanhos localizados no Estado de Rondônia. A área de estudo foi de 25.088,40 km2, localizada na microrregião de Ji-Paraná. A dependência espacial para os indicadores de qualidade do leite foi avaliada por meio de semivariogramas. Havendo dependência espacial, estimaram-se valores do indicador em estudo para os locais não amostrados dentro do espaço, sem tendenciosidade e com variância mínima, pelo método denominado Krigagem, para interpolação de dados. Os resultados mostraram que houve dependência espacial para a gordura, lactose, estrato seco desengordurado (ESD, contagem de células somáticas (CCS e contagem total de bactérias (CTB. Foi observada uma dependência espacial fraca para gordura e ESD. Entretanto, foi identificada uma dependência espacial moderada para lactose, CCS e CTB. Sugere-se que a dependência espacial fraca e moderada encontrada no estudo foi devido ao número de fazendas incluídas no estudo até o momento. Os mapas gerados no estudo mostraram as áreas com valores diferenciados para os indicadores de qualidade do leite. A análise espacial dos indicadores de qualidade do leite mostrou ser uma ferramenta viável para avaliar a variação dos componentes do leite, CCS e CTB entre áreas de uma mesma região. As informações geradas por meio de mapas de

  20. Simultaneous estimation of QTL parameters for mapping multiple traits

    Indian Academy of Sciences (India)

    LIANG TONG

    2018-03-13

    XM ji ) denotes the conditional probability of the QTL genotype. X. ∗ ji (QiQi, Qiqi or ... random error of the ith trait value of the jth subject, with mean zero and ..... to adjust the conditional probabilities in table 1 when conducting ...

  1. Untitled

    Indian Academy of Sciences (India)

    Zeiger and Pratt 1973). Ji-X, X. A.E. (11). 3.1 Transfer integrals and covalency parameter. Using equation (8) Srivastava et al w (1979) have obtained the values of the transfer. Integrals from the experimental valu of Ji given in table 1.

  2. Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls

    Directory of Open Access Journals (Sweden)

    Hua XP

    2015-09-01

    Full Text Available Xian-Ping Hua,1,* Xiao-Dong Zhang,2,* Joey SW Kwong,3,* Xian-Tao Zeng,4 Zhen-Jian Zhang,1 Wan-Lin Wei21Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, 2Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, Beijing, 3Chinese Evidence-Based Medicine Center and Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, 4Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workBackground: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α gene G-238A polymorphism and risk of coronary artery disease (CAD using a meta-analytical approach.Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs and their 95% confidence intervals (CIs.Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89–1.30; AA vs GG: OR =1.15, 95% CI =0.59–2.25; GA vs GG: OR =1.14, 95% CI =0.88–1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56–2.14; (GA + AA vs GG: OR =1.11, 95% CI =0.90–1.38. In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism

  3. Top five medical innovations in China mainland since Xinhai revolution [1911]: results of AME survey-002.

    Science.gov (United States)

    Wáng, Yì-Xiáng J; Xiao, Fan

    2015-06-01

    This survey aims to scrutinize important medical innovations in Chinese mainland since Xinhai (Hsin-hai) revolution in 1911, which marked the end of Manchurian imperial rule and the beginning of China's republican era. An online cross-sectional survey was carried out during the period of Dec 29, 2014 to Feb 5, 2015, totaling 37 days. The survey was conducted on the platform provided by DXY (www.dxy.cn), which is the largest medical and paramedical related website in China. An email was sent to all DXY registered users to invite them to participate in a 5-minute survey. The participants were asked to nominate up to four important medical innovations in China mainland since Xinhai revolution. The participant could select 'zero' which means he/she felt there was no important medical innovations, or he/she did not know important medical innovations. It was noted that important medical innovations refer to (I) those with practical and almost immediate significance to improve healthcare; (II) should not only be introducing western technique to China, but those involve major improvement of existing western techniques count; (III) should not be those with important theoretical discovery but did not have almost immediate significance to improve healthcare. In total 1,513 DXY users participated in the voting. Totally 489 (32.3%), 441 (29.1%), 342 (22.6%), 150 (9.9%), 91 (6.0%) participants provided 0, 1, 2, 3, 4 nominations respectively. (I) Artemisine (Qinghaosu) for malaria treatment (Project 523 team, 1972); (II) arsenic Trioxide (As2O3) for acute promyelocytic leukemia (APL) treatment (ZHANG Ting-Dong and colleagues, 1970s); (III) limb re-plantation (CHEN Zhong-Wei and colleagues, 1963); (IV) all-trans retinoic acid (ATRA) for APL treatment (WANG Zhen-Yi and colleagues, 1988); and (V) Wu's mask for plague prevention (WU Lien-The, 1910), were voted as the top five innovations in China mainland since Xinhai revolution, with 375, 96, 91, 53, and 8 votes respectively. In

  4. Observation des influences du changement du couvert forestier sur le comportement hydrologique de grands bassins versants tropicaux a l'aide de la teledetection numerique: Cas du bassin versant de Dong Nai, Viet Nam

    Science.gov (United States)

    Pham, Trinh Hung

    Monitoring hydrological behavior of a large tropical watershed following a forest cover variation has an important role in water resource management planning as well as for forest sustainable management. Traditional methods in forest hydrology studies are Experimental watersheds, Upstream-downstream, Experimental plots, Statistical regional analysis and Watershed simulation. Those methodes have limitations for large watersheds concerning the monitoring time, the lack of input data especially about forest cover and the capacity of extrapolating results accurately in terms of large watersheds. Moreover, there is still currently a scientific debate in forest ecology on relation between water and forest. The reason of this problem comes from geographical differences in publication concerning study zones, experimental watershed size and applied methods. It gives differences in the conclusions on the influence of tropical forest cover change on the changes of outlet water and yet on the yearly runoff in terms of large watershed. In order to exceed the limitations of actual methods, to solve the difficulty of acquiring forest cover data and to have a better understanding of the relation between tropical forest cover change and hydrological behavior evolution of a large watershed, it is necessary to develop a new approach by using numeric remote sensing. We used the watershed of Dong Nai as a case study. Results show that a fusion between TM and ETM+ Landsat image series and hydro-meteorologic data allow us to observe and detect flooding trends and flooding peaks after an intensive forest cover change from 16% to 20%. Flooding frequency and flooding peaks have clearly decreased when there is an increase of the forest cover from 1983 to 1990. The influence of tropical forest cover on the hydrological behavior is varying with geographical locations of watershed. There is a significant relation between forest cover evolution and environmental facteurs as the runoff

  5. On multi-level thinking and scientific understanding

    Science.gov (United States)

    McIntyre, Michael Edgeworth

    2017-10-01

    Professor Duzheng YE's name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960s. I had the enormous pleasure of meeting Professor YE personally in 1992 in Beijing. His concern to promote the very best science and to use it well, and his thinking on multi-level orderly human activities, reminds me not only of the communication skills we need as scientists but also of the multi-level nature of science itself. Here I want to say something (a) about what science is; (b) about why multi-level thinking—and taking more than one viewpoint—is so important for scientific as well as for other forms of understanding; and (c) about what is meant, at a deep level, by "scientific understanding" and trying to communicate it, not only with lay persons but also across professional disciplines. I hope that Professor YE would approve.

  6. Fibrillation mechanism of a model intrinsically disordered protein revealed by 2D correlation deep UV resonance Raman spectroscopy.

    Science.gov (United States)

    Sikirzhytski, Vitali; Topilina, Natalya I; Takor, Gaius A; Higashiya, Seiichiro; Welch, John T; Uversky, Vladimir N; Lednev, Igor K

    2012-05-14

    Understanding of numerous biological functions of intrinsically disordered proteins (IDPs) is of significant interest to modern life science research. A large variety of serious debilitating diseases are associated with the malfunction of IDPs including neurodegenerative disorders and systemic amyloidosis. Here we report on the molecular mechanism of amyloid fibrillation of a model IDP (YE8) using 2D correlation deep UV resonance Raman spectroscopy. YE8 is a genetically engineered polypeptide, which is completely unordered at neutral pH yet exhibits all properties of a fibrillogenic protein at low pH. The very first step of the fibrillation process involves structural rearrangements of YE8 at the global structure level without the detectable appearance of secondary structural elements. The formation of β-sheet species follows the global structural changes and proceeds via the simultaneous formation of turns and β-strands. The kinetic mechanism revealed is an important new contribution to understanding of the general fibrillation mechanism proposed for IDP.

  7. The effect of waaL genes deletion from Yersinia enterocolitica O:3 genome on bacteria LPS’ phenotype

    Directory of Open Access Journals (Sweden)

    Shevchenko J. I.

    2014-11-01

    Full Text Available Aim. To estimate WaaL ligase contribution in the lipopolysaccharide (LPS phenotype profile formation of Y. enterocolitica O:3 (YeO3 bacteria. Methods. The waaL-knock-out mutants were created by an allelic exchange strategy. The LPS phenotypes of created mutants were visualized by silver-stained DOC-PAGE and immunoblotting with specific outer core (core oligosaccharide, hexasaccharide, OC and O-polysaccharide (OPS or O-Ag monoclonal antibodies. Results. Deletion of waaLOS gene from YeO3 genome has a marked effect on OC ligation in either single or double mutants. The waaLPS deletion has an opposite effect on the OPS ligation – barely detected increasing of OPS bands. Conclusions. The LPS ligases of YeO3 exhibit relaxed donor substrate specificity. Under given conditions the effect of WaaLOS ligase is more significant for OC and OPS ligation onto lipid A than that of WaaLPS.

  8. A Framework for the Assessment of the Global Potential of Joint Implementation

    NARCIS (Netherlands)

    Bollen JC; Minnen JG van; Toet AMC; Bennis M; Kuik OJ; MTV; VUA/IVM

    1995-01-01

    Joint Implementation (JI) is een instrument om op goedkopere wijze de mondiale CO2 uitstoot te verminderen. Het mondiale potentieel voor JI is gedefinieerd als de fractie van de noodzakelijke vermindering van regionale CO2 uitstoot om de uitstootdoelstelling in een bepaald zichtjaar te bereiken,

  9. DsRed gene expression by doxycycline in porcine fibroblasts and ...

    African Journals Online (AJOL)

    DsRed gene expression by doxycycline in porcine fibroblasts and cloned embryos using transposon. SuJin Kim, JoonHo Moon, BegoRoibas da Torre, Islam M Saadeldin, JungTaek Kang, JiYei Choi, SolJi Park, Byeong-Chun Lee, Goo Jang Goo Jang ...

  10. Projects of Earth Sciences Supported by National Natural Science Foundation of China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    -jie 40071002\tResearch into the Spatial Variation of the Effective temperature and Its Functions to Vegetation Landscape in Mountainous Areas\tJIANG Yuan 40071003\tCompilation of Coching Chu's Collected Works and Research on His Scientific Innovation Prints FAN Hong-ye 40071004\tThe Study of the Theory and Experiment on the Water Resource Demanded by the Eco-environment in Arid Region\tJIA Bao-quan 40071005\tQuantitative Analysis on the Difference of Environmental Fragile Degree under Global Change in the Two Sides of Qinling Mountains\tYAN Jun-ping 40071006\tHigh Resolution Studies of the Holocene Climatic and Hydrological Events in the Weihe River Basin\tHUANG Chun-chang 40071007\tA Land Surface Processes Coupling Model and Observation in Alpine Meadow\tYAO De-liang 40071008\tEffects of Groundwater on Land Surface Processes and Agricultural Ecology\tYU Qiang 40071009\tStudy on the Relationship Between Vegetation Change and Main Hydraulic Process in the Oasis-Desert Ecotone\tZHAO Cheng-yi 40071010\tExperimental Research on Stress Constitutive Relation of Debris Flow in the Field\tWANG Yu-yi 40071011\tFrom a Longitudinal Section to Research the Environmental Change during the Late Quaternary in the Inland of South China Tropical Zone\tHUANG Zhen-guo 40071012\tRelations Between Dune Lee-side Cross-bedding, Morphology, and Different Scale of Air-flow\tHA Si 40071013\tFormation Mechanism and Evolution Processes of Flood Channels in the Changjiang Estuary\tSHEN Huan-ting 40071014\tThe Beach Changes under Wave Action on Tidal Coastal Area\tBAO Si-lin 40071015\tEvolution of Glaciers and Monsoon during the Last Glaciation in the Gongwang Mountain of Yunnan and Yu Mountain of Taiwan\tCUI Zhi-jiu 40071016\tGeomorphic Variation Model of the Yellow River Between the Hukou Fall and the Xiaolangdi Reservoir\tLI You-li 40071017\tStudy on Coupling of Karst Surface and Subsurface (Cave) Ecologic and Environment Systems and Speleothem Scenic Stability\tSONG Lin-hua 40071018\tWind Tunnel

  11. Role of Stat3 and ErbB2 in Breast Cancer

    Science.gov (United States)

    2013-12-01

    Nemoto, K.E. Pestell , K. Cooley, E.C. Southwick, D.A. Mitchell, W. Furey, R. Gussio, D.W. Zaharevitz, B. Joo, P. Wipf, Identification of a potent...7). Inorg Chem 2008, 47:2798–2804. 26. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, et al: Stat3 as an oncogene. Cell...Biochem Biophys Res Commun 382: 440-444, 2009. 7 Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE Jr.: Stat3 as an

  12. Vatuximab(Trademark): Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

    Science.gov (United States)

    2010-01-01

    159: 621-631, 2003. 37. Bourke , V. A., Zhao, D., Gilio, J., Chang, C.-H., Jiang, L., Hahn, E. W., and Mason, R. P. Correlation of Radiation...probe: comparison with a paired survival assay. Radiat Res, 158, 167-73 (2002) 27. Gu, Y. Q., V. A. Bourke , J. G. Kim, A. Constantinescu, R. P. Mason...Res. 1998; 150: 549–556. 10. Bourke VA, Zhao D, Gilio J, Chang C-H, Jiang L, Hahn EW, Mason RP. Correlation of radiation response with tumor oxygen

  13. Domestic climate regimes and incentives for private sector involvement in joint implementation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This report analyses how effective incentive structures can be put in place for private sector involvement in pilot projects (AIJ, Activities Implemented Jointly) and, in due time, joint implementation (JI). Due to the short time record of AIJ/JI experience, lessons are drawn from other related policy areas: studies of public/private interface in environmental- and climate policy in the Netherlands, USA, Norway and Costa Rica. The report concludes with status and prospects for private sector incentives in the pilot phase and then provides lessons and proposals for such incentives in a more mature and ambitious JI regime with crediting. 22 refs.

  14. FY 1999 report on the study of the future course, etc. of 'the basic survey for promotion of Joint Implementation, etc.'; 1999 nendo 'kyodo jisshi nado suishin kiso chosa' no kongo no hokosei nado ni kansuru kento chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The paper conducted the demonstration of the multiplier effect of 'the model project for heightening of the international energy consumption efficiency, etc.' carried out by NEDO and its subsidiary project, 'the project on the basic survey for promotion of Joint Implementation (JI),' and the comparative study between these projects and the JI/CDM projects proposed in the world. In the quantitative evaluation of the multiplier effect, in the case of making the demonstration of the same technology in the same area both in the model project and the basic survey for promotion of JI, it becomes possible to grasp the CO2 reduction effect with high accuracy, but the CO2 reducible amount is small. Inversely, as to the technology for which the basic survey for promotion of JI is studied, but the model project is not carried out, it becomes possible to grasp the CO2 reduction effect with low accuracy, the CO2 reducible amount is large. In the comparison with the JI/CDM projects proposed in the world, the CO2 reduction amount was approximately $2.7 billion, 250 million tons, in the UNFCCC project, and approximately $5.0 billion, 500 million tons, in the IJ project. There was no very big difference in the cost effect. (NEDO)

  15. FY 1999 report on the study of the future course, etc. of 'the basic survey for promotion of Joint Implementation, etc.'; 1999 nendo 'kyodo jisshi nado suishin kiso chosa' no kongo no hokosei nado ni kansuru kento chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The paper conducted the demonstration of the multiplier effect of 'the model project for heightening of the international energy consumption efficiency, etc.' carried out by NEDO and its subsidiary project, 'the project on the basic survey for promotion of Joint Implementation (JI),' and the comparative study between these projects and the JI/CDM projects proposed in the world. In the quantitative evaluation of the multiplier effect, in the case of making the demonstration of the same technology in the same area both in the model project and the basic survey for promotion of JI, it becomes possible to grasp the CO2 reduction effect with high accuracy, but the CO2 reducible amount is small. Inversely, as to the technology for which the basic survey for promotion of JI is studied, but the model project is not carried out, it becomes possible to grasp the CO2 reduction effect with low accuracy, the CO2 reducible amount is large. In the comparison with the JI/CDM projects proposed in the world, the CO2 reduction amount was approximately $2.7 billion, 250 million tons, in the UNFCCC project, and approximately $5.0 billion, 500 million tons, in the IJ project. There was no very big difference in the cost effect. (NEDO)

  16. Design and Flood Control Assessment of 5MWp Fishing and Photovoltaic Power Project in Xinghua City

    Science.gov (United States)

    Guo, Liuchao; Hu, Xiaodong; Su, Yuyan; Wu, Peipei; Weng, Songgan

    2017-12-01

    In order to reduce coal consumption in Jiangsu Province and develop new energy sources, considering on the distribution of geology, solar energy resources, traffic and grid connection in Xinghua City, the aim is to determine the configuration of photovoltaic modules and photovoltaic array tracking mode, design photovoltaic array and layout scheme. But the project is a wading project, it is built in Dong Tan Lake polder I115, it needs scientific and reasonable evaluation to the effect of Dong Tan Lake’s flood storage and discharge. The results can provide guidance for similar engineering’s design.

  17. The Militia of Jin-Cha-Ji Border Area in the Anti-Japanese War Period%抗战时期晋察冀边区的民兵

    Institute of Scientific and Technical Information of China (English)

    栾盈菊

    2013-01-01

    晋察冀民兵是在共产党的动员和领导下建立和壮大起来的不脱离生产的群众武装。民兵的任务是进行游击战、配合部队作战和担任抗战勤务。民兵的军事战术有麻雀战、地雷战、地道战、扭击战和伏击战等。在民兵队伍中,由于有党的政治动员、党员的带头作用、有组织的军事政治教育和组织的民主性等原因,民兵成为打败日寇的重要力量,同时民兵也是主力军与游击队的助手,是主力军的重要兵源。%The militia of Jin-Cha-Ji border area was the armed masses without departing from the pro-duction,which was established and grew under the leadership of the Party.Its mission was to carry outguerrilla warfare,cooperate with the troops and act as war service.It had many tactics,such as sparrowwarfare,mine warfare,tunnel warfare,torsional warfare and ambush operation.Due to the Party’s politi-cal mobilization and the Party members’leading role,with organized military and political education anddemocratic nature of the organization,the militia was not only an important force to beat the Japanese,butalso assistant of the main force and the guerrillas,and the important sources for the recruits of the mainforce troops.

  18. Strategy iteration is strongly polynomial for 2-player turn-based stochastic games with a constant discount factor

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Miltersen, Peter Bro; Zwick, Uri

    2011-01-01

    Ye showed recently that the simplex method with Dantzig pivoting rule, as well as Howard's policy iteration algorithm, solve discounted Markov decision processes (MDPs), with a constant discount factor, in strongly polynomial time. More precisely, Ye showed that both algorithms terminate after...... iterations. Second, and more importantly, we show that the same bound applies to the number of iterations performed by the strategy iteration (or strategy improvement) algorithm, a generalization of Howard's policy iteration algorithm used for solving 2-player turn-based stochastic games with discounted zero...

  19. Games to get Hegemony in Iranian Politics : Participation of Islamic Jurists after the Revolution

    OpenAIRE

    Kuroda, Kenji

    2009-01-01

    After the Iranian Islamic Revolution in 1979, Islamic jurists have played an important role in the political arena of the new establishment. This paper aimed to describe changes in the Shī'ite jurisprudence academia in contemporary Iran, especially after the revolution. Thus I focused on owze-ye 'Elmīye (Shī'ite learning institution) in Qom before and after the revolution. Then I figured out the changes in the educational aspect and the administrative aspect. In addition, I tried to reveal a ...

  20. The 2nd International Conference on Agricultural and Biological Sciences (ABS 2016

    Directory of Open Access Journals (Sweden)

    Lei Pei

    2016-10-01

    Full Text Available Table of contents 01 The influence of soil salt content on the photosynthetic characteristics of spring wheat with trickle irrigation Lei Pei, Zhenhua Wang, Jinzhu Zhang, Wenhao Li 02 Comparing growth of fast-growing and slow-growing endophytes in plants via ergosterol quantification Adeline SY Ting, Yiing Y Chow, Sadequr Rahman 03 Transcriptome and digital gene expression analysis identifies putative triterpene saponin-biosynthetic genes of Panax notoginseng Rongchang Wei 04 Chitosan-assisted isolation and antioxidant evaluation of flavonoids from Sophora japonica L. Zhang Hu, Sidong Li, Chuyan Li, Zijuan Li 05 Two kinds of new characteristics of the ektexine ornamentation of ginkgo pollen Guoxia Wang, Yuzhen Yang, Gang Chen, Qing Luo 06 Analysis of nutrient and medicinal ingredients of Ginkgo pollen in different regions Guoxia Wang, Ruixia Liu, Yuzhen Yang, Lipei Chen 07 Photosynthetic performance of greening seedlings of seven species to drought stress Zhiyang Lie, Tongtong Zhou, Weilong Huang, Li Xue 08 Changes of fluorescence parameters of greening seedlings of seven species under drought stress Jie Li, Zhuomin Wang, Li Xue 09 Mammalian sex hormone affects regeneration capacity and enzymes activity of Triticale L in vitro culture Ismail Bezirganoglu, Pınar Uysal 10 Fractional Fourier entropy increases the recognition rate of fruit type detection Shuihua Wang, Zhihai Lu, Jiquan Yang, Yudong Zhang, John Liu, Ling Wei, Shufang Chen, Preetha Phillips, Zhengchao Dong 11 Banana-peanut intercropping reduces Fusarium wilt disease in banana from enhancing soil bacterial microorganisms and leaf nutrition Hong Li, Xutong Wang, Fengliang Zhao, Guisheng Yang 12 Manganese stress impairs stem ureide nitrogen fixation in yardlong-bean plants in the acidic environment Hong Li 13 A new pest control method for Rhytidodera bowringii Larvae Haijie Huang, Li Zhao, Weijian Huang, Jinhui Wang, Zhongrun Zhang 14 Research on the seed-like Fruits of Subg. Sclarea of

  1. Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

    Directory of Open Access Journals (Sweden)

    Yu D

    2016-01-01

    Full Text Available Debin Yu,1 Mingzhi Zhao,2 Liwei Dong,1 Lu Zhao,1 Mingwei Zou,3 Hetong Sun,4 Mengying Zhang,4 Hongyu Liu,4 Zhihua Zou1 1National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 2State Key Laboratory of Proteomics, National Engineering Research Center for Protein Drugs, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3Department of Psychology, College of Liberal Arts and Social Sciences, University of Houston, Houston, TX, USA; 4Prosit Sole Biotechnology, Co., Ltd., Beijing, People’s Republic of China Abstract: Type III interferons (IFNs (also called IFN-λ: IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4 are critical players in the defense against viral infection of mucosal epithelial cells, where the activity of type I IFNs is weak, and unlike type I IFNs that are associated with severe and diverse side effects, type III IFNs cause minimal side effects due to the highly restricted expression of their receptors, and thus appear to be promising agents for the treatment and prevention of respiratory and gastrointestinal viral infection. However, the antiviral potency of natural type III IFNs is weak compared to type I and, although IFN-λ3 possesses the highest bioactivity among the type III IFNs, IFN-λ1, instead of IFN-λ3, is being developed as a therapeutic drug due to the difficulty to express IFN-λ3 in the prokaryotic expression system. Here, to develop optimal IFN-λ molecules with improved drug attributes, we designed a series of IFN-λ analogs by replacing critical amino acids of IFN-λ1 with the IFN-λ3 counterparts, and vice versa. Four of the designed analogs were successfully expressed in Escherichia coli with high yield and were easily purified from inclusion bodies. Interestingly, all four analogs showed potent activity in inducing the

  2. Bērnu mārketinga attīstība Latvijas lielāko pārtikas produktu ražotāju tirgus darbībās

    OpenAIRE

    Lūse, Ieva

    2010-01-01

    Uzņēmumi visā pasaulē arvien vairāk sāka apzināties bērnu potenciālu tirgū un aktivizē savu komunikāciju ar bērnu auditoriju. Bērni vienlaicīgi tirgū pilda vairākas lomas kā patērētāji, iniciatori, ietekmētāji un lēmēji par pirkumu un pircēji šodien un nākotnē, kļūstot par daudzu uzņēmumu produkcijas pamata patērētājiem. Ņemot vērā tēmas aktualitāti autore par maģistra darba mērķi izvirza apzināt un analizēt lielāko Latvijas pārtikas produktu ražotāju aktivitāti bērnu mārketing...

  3. Prognostic and clinicopathological significance of serum interleukin-6 expression in colorectal cancer: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Wang Z

    2015-12-01

    Full Text Available Zhen Wang,1 Pin Wu,1,2 Dang Wu,1 Zhigang Zhang,3 Guoming Hu,1 Shuai Zhao,1 Yucheng Lai,1 Jian Huang1,41Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Key Laboratory of Molecular Biology in Medical Sciences, China National Ministry of Education, 2Department of Thoracic Surgery, 3Department of Gynecology, 4Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of ChinaPurpose: Interleukin-6 (IL-6 plays an important role in human colorectal cancer (CRC development. However, the exact clinical and prognostic significance of IL-6 in CRC is still unclear. Here, we conducted this meta-analysis to explore this issue in detail.Methods: A meta-analysis was performed to clarify the association between serum IL-6 expression and clinical outcomes in articles published up to June 2015. Weighted mean difference (WMD and its corresponding 95% confidence interval (CI were used to assess the association between serum IL-6 expression and the clinicopathological characteristics of CRC. Hazard ratio (HR with 95% CI was used to quantify the predictive value of IL-6 on CRC prognosis.Results: Fourteen studies comprising 1,245 patients were included. Analysis of these data showed that serum IL-6 expression was highly correlated with poor 5-year overall survival (OS rate (HR =0.43, 95% CI: 0.31–0.59, P=0.755. Simultaneously, we also found that serum IL-6 expression was associated with certain clinical parameters of CRC, such as tumor invasion (T category: T0–T2, T3–T4 (WMD =3.15, 95% CI: 1.92–4.39, P=0.816, distant metastasis (M category: M0, M1 (WMD =4.69, 95% CI: 3.33–6.06, P=0.377, and tumor stage (I–II, III–IV (WMD =2.65, 95% CI: 1.09–4.21, P=0.066.Conclusion: A high serum IL-6 expression is associated with adverse OS in CRC. The IL-6 expression can be an important supplement in establishing prognostic score

  4. Novel guanidinylated bioresponsive poly(amidoamines designed for short hairpin RNA delivery

    Directory of Open Access Journals (Sweden)

    Yu J

    2016-12-01

    Full Text Available Jiankun Yu,1 Jinmin Zhang,1 Haonan Xing,1 Yanping Sun,1 Zhen Yang,1 Tianzhi Yang,2 Cuifang Cai,1 Xiaoyun Zhao,3 Li Yang,1 Pingtian Ding1 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; 2Department of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME, USA; 3Department of Microbiology and Cell Biology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China Abstract: Two different disulfide (SS-containing poly(amidoamine (PAA polymers were constructed using guanidino (Gua-containing monomers (ie, arginine [Arg] and agmatine [Agm] and N,N'-cystamine bisacrylamide (CBA by Michael-addition polymerization. In order to characterize these two Gua-SS-PAA polymers and investigate their potentials as short hairpin RNA (shRNA-delivery carriers, pSilencer 4.1-CMV FANCF shRNA was chosen as a model plasmid DNA to form complexes with these two polymers. The Gua-SS-PAAs and plasmid DNA complexes were determined with particle sizes less than 90 nm and positive ζ-potentials under 20 mV at nucleic acid:polymer weight ratios lower than 1:24. Bioresponsive release of plasmid DNA was observed from both newly constructed complexes. Significantly lower cytotoxicity was observed for both polymer complexes compared with polyethylenimine and Lipofectamine 2000, two widely used transfection reagents as reference carriers. Arg-CBA showed higher transfection efficiency and gene-silencing efficiency in MCF7 cells than Agm-CBA and the reference carriers. In addition, the cellular uptake of Arg-CBA in MCF7 cells was found to be higher and faster than Agm-CBA and the reference carriers. Similarly, plasmid DNA transport into the nucleus mediated by Arg-CBA was more than that by Agm-CBA and the reference carriers. The study suggested that guanidine and carboxyl introduced into Gua-SS-PAAs polymers resulted in a better nuclear localization effect, which played a key role in the

  5. Heat flow from Io /JI/

    Science.gov (United States)

    Matson, D. L.; Ransford, G. A.; Johnson, T. V.

    1981-01-01

    The existing ground-based measurements of Io's thermal emission at infrared wavelengths of 8.4, 10.6, and 21 microns have been reexamined. Present in these data is the signature of hot spots, presumably similar to the hot spots seen by the IRIS experiment on Voyager. It is possible to extract from these data the total amount of power radiated. Since the hot spots are believed to be a result of deep-seated activity in Io and since the remainder of Io's surface is an extraordinarily poor thermal conductor, the power radiated by the hot spots is essentially the total heat flow. The analysis yields a heat flow of 2 + or - 1 W/sq m. This value is tremendously large in comparison to the average heat flow of the earth (0.06 W/sq m) and the moon (0.02 W/sq m), but is characteristic of active geothermal areas on the earth. A heat flow this large requires that the interior of Io be at least partially molten on a global scale.

  6. Efficacy of a biomechanically-based yoga exercise program in knee osteoarthritis: A randomized controlled trial.

    Science.gov (United States)

    Kuntz, Alexander B; Chopp-Hurley, Jaclyn N; Brenneman, Elora C; Karampatos, Sarah; Wiebenga, Emily G; Adachi, Jonathan D; Noseworthy, Michael D; Maly, Monica R

    2018-01-01

    Certain exercises could overload the osteoarthritic knee. We developed an exercise program from yoga postures with a minimal knee adduction moment for knee osteoarthritis. The purpose was to compare the effectiveness of this biomechanically-based yoga exercise (YE), with traditional exercise (TE), and a no-exercise attention-equivalent control (NE) for improving pain, self-reported physical function and mobility performance in women with knee osteoarthritis. Single-blind, three-arm randomized controlled trial. Community in Southwestern Ontario, Canada. A convenience sample of 31 women with symptomatic knee osteoarthritis was recruited through rheumatology, orthopaedic and physiotherapy clinics, newspapers and word-of-mouth. Participants were stratified by disease severity and randomly allocated to one of three 12-week, supervised interventions. YE included biomechanically-based yoga exercises; TE included traditional leg strengthening on machines; and NE included meditation with no exercise. Participants were asked to attend three 1-hour group classes/sessions each week. Primary outcomes were pain, self-reported physical function and mobility performance. Secondary outcomes were knee strength, depression, and health-related quality of life. All were assessed by a blinded assessor at baseline and immediately following the intervention. The YE group demonstrated greater improvements in KOOS pain (mean difference of 22.9 [95% CI, 6.9 to 38.8; p = 0.003]), intermittent pain (mean difference of -19.6 [95% CI, -34.8 to -4.4; p = 0.009]) and self-reported physical function (mean difference of 17.2 [95% CI, 5.2 to 29.2; p = 0.003]) compared to NE. Improvements in these outcomes were similar between YE and TE. However, TE demonstrated a greater improvement in knee flexor strength compared to YE (mean difference of 0.1 [95% CI, 0.1 to 0.2]. Improvements from baseline to follow-up were present in quality of life score for YE and knee flexor strength for TE, while both also

  7. Ultrafast Optics: Vector Cavity Laser - Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  8. Ultrafast Optics - Vector Cavity Lasers: Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  9. Ultrafast Optics: Vector Cavity Fiber Lasers - Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  10. Oxidative Lung Injury in Virus-Induced Wheezing

    Science.gov (United States)

    2015-07-01

    respiratory syncytial virus Yashoda M. Hosakote,1 Narayana Komaravelli,1 Nicolas Mautemps,1 Tianshuang Liu,1 Roberto P. Garofalo,1,2,3 and Antonella Casola1,2,3...1097/MNH.0b013e3283430651. 5. Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, Zhao Y, Baskar R, Tan CH, Moore PK. 2008. Characterization of a novel...L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, Zhao Y, Baskar R, Tan CH, Moore PK. Characterization of a novel, water-soluble hydrogen sulfide

  11. Laser-induced damage study of polymer PMMA; Motale-e-ye padid-e-ye khesarat-e mavvad-e polimeri PMMA dar moghabel-e barik-e-ye laizer

    Energy Technology Data Exchange (ETDEWEB)

    Mansour, N

    2001-07-01

    This article presents the results of bulk laser-induced damage measurements in polymer PMMA at 532 nm and 1064 nm for nanosecond laser pulses. The damage thresholds were measured for focused spot sizes ranging over two orders of magnitude. In this work, self-focusing effects were verified to be absent by measurements of breakdown thresholds using both linearly and circularly polarized light. At both 1064 nm and 532 nm, the dependence of the breakdown field, E{sub B}, on the spot size, {omega}, was empirically determined to be E{sub B} = C/{radical}{omega}, where C depends on the wavelength. The extracted value for C({lambda}) at 1064 nm is larger by a factor of 5 than at 532 nm. Possible reasons for this strong dispersion and mechanism for laser-induced damage in polymer materials will be discussed.

  12. Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots

    International Nuclear Information System (INIS)

    Qu, Fei; Sun, Zhe; Liu, Dongya; Zhao, Xianen; You, Jinmao

    2016-01-01

    The authors describe dual-emission carbon nanodots containing blue emitters (BE; peak emission at 385 nm under 315 nm excitation) and yellow emitters (YE; peak emission at 530 nm under 365 nm excitation), and how they can be applied to direct and indirect determination of tetracyclines (TCs). The direct detection scheme is based on the finding that tetracycline (TET), oxytetracycline, chlortetracycline and doxycycline quench the two emissions of the carbon dots. While direct determination is rapid and convenient, it cannot differentiate between TCs. The indirect detection scheme, in contrast, is based on the finding that Al (III) ions enhance the fluorescence of the YE in the carbon dots, and that they cause a blue shift in emission. It is, however, known that TET forms a strong complex with Al (III), and this can inhibit the interaction between Al (III) and the YE, so that the fluorescence of YE is not enhanced and blue-shifted by Al (III) in the presence of TET. This finding is exploited in a fluorescence turn-on/off assay for TET that can distinguish TET from other TCs. The linear range of indirect determination for TET extends from 1 nM to 30 μM, and the limit of detection is 0.52 nM. The indirect method was successfully applied to the determination of TET in spiked milk, fish and pork, and recoveries ranged from 91.7 to 102 %. (author)

  13. Mexico joins the venture: Joint Implementation and Greenhouse Gas Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Imaz, M.; Gay, C.; Friedmann, R.; Goldberg, B.

    1998-11-01

    Joint Implementation (JI) and its pilot phase of Activities Implemented Jointly (AIJ) are envisioned as an economic way of reducing global emissions of greenhouse gases. This paper draws upon the Mexican experience with AIJ to identify Mexican concerns with AIJ/JI and proposed solutions to these. Three approved Mexican AIJ projects (Ilumex, Scolel Te, and Salicornia) are described in detail. The Ilurnex project promotes the use of compact fluorescent lamps in Mexican homes of the States of Jalisco and Nuevo Leon, to reduce electric demand. Scolel Te is a sustainable forest management project in Chiapas. Salicornia examines the potential for carbon sequestration with a Halophyte-based crop irrigated with saline waters in Sonora. These three projects are reviewed to clarify the issues and concerns that Mexico has with AIJ and JI and propose measures to deal with them. These initial Mexican AIJ projects show that there is a need for creation of standard project evaluation procedures, and criteria and institutions to oversee project design, selection, and implementation. Further JI development will be facilitated by national and international clarification of key issues such as additionality criteria, carbon-credit sharing, and valuation of non-GHG environmental and/or social benefits and impacts for AIJ projects. Mexico is concerned that JI funding could negatively impact official development assistance or that OECD countries will use JI to avoid taking significant GHG mitigation actions in their own countries. The lack of carbon credit trading in the AIJ stage must be removed to provide useful experience on how to share carbon credits. National or international guidelines are needed to ensure that a portion of the carbon credits is allocated to Mexico.

  14. Bilimsel iletişimde yeşil ve altın yollarda yakınsama ve Türkiye'deki yansımaları = Convergence of the gold and green roads at scholarly communication and reflections on Turkey

    Directory of Open Access Journals (Sweden)

    Şengül, Gökhan

    2011-01-01

    Full Text Available Son yıllarda özellikle sosyal ağlarda bilgi dolaşımının artması, gelişmiş mobil iletişim cihazlarının yoğun kullanımı kısıtsız ve farklı ortamlarda bilgi erişim ve paylaşımını gerektirmektedir. Bu bağlamda bilimsel bulguların yer aldığı makalelerin geniş kitlelere ve diğer bilim insanlarının erişimine açılması; hem bilimsel eserin doğruluk ve güvenirliğini artırmaya yardımcı olmakta, hem de bilimsel verinin paylaşılmasını ve dolayısı ile de bilimsel gelişimi olumlu yönde etkilemektedir. Yaklaşık on yıldır bu amaca açık erişim insiyatifi katkı sağlamaktadır. Bu amaçla kendi kendine arşivleme (yeşil yol ve açık erişim dergisi (altın yol bilimsel çalışmaların bilim topluluğuna sunulmasında yeni yöntemler olarak takdim edilmiştir Bu çalışmada; uluslararası alanda yeşil ve altın yollar üzerinde ortaya konan kurallar irdelenmiş, yazar ve yayıncılarının oluşan iklime uyumluluğu sorgulanmış ve Türkiye adresli kurumsal arşiv ve dergilerin ortaya çıkan durum karşısında konumları üzerine bir değerlendirme yapılmıştır. Çalışma esnasında Ulrich Süreli Yayın Rehberi, Thomson Reuters (ISI Bilimsel Web (Web of Science - WoS ve Elsevier Scopus uluslararası ticari atıf veri tabanları, RoMEO, Juliet, ve ROARMAP telif politikası rehberleri, OpenDOAR, ROAR kurumsal arşiv rehberleri ve DOAJ açık erişim dergisi rehberi ile ULAKBİM ulusal veri tabanları incelenmiştir. / In parallel with the increase of information exchange rate in social networks and the usage of mobile communication devices in recent years, it is also required that the information needs to be shared and freely accessable in different enviroments. In this context freely access to the papers including scientific findings by other scientists and broad population will help to increase both the accuracy and reability of the papers. Besides it will also affect positively the

  15. Etude Climat no. 33 'Joint Implementation: a frontier mechanism within the borders of an emissions cap'

    International Nuclear Information System (INIS)

    Shishlov, Igor; Bellassen, Valentin; Leguet, Benoit

    2012-01-01

    Among the publications of CDC Climat Research, 'Climate Reports' offer in-depth analyses on a given subject. This issue addresses the following points: Based on specific projects rather than economy-wide emissions reductions, and driven by the demand from the installations covered by the European Union Emissions Trading Scheme (EU ETS), Joint Implementation (JI) turned out to be a largely private sector mechanism. Besides attracting private investors in GHG abatement projects, JI creates an opportunity for countries to exploit the arbitrage price spread between different carbon offsets: Emission Reduction Units (ERU), the credits issued from JI projects, trade with a premium of up to 50% over Assigned Amount Units (AAU), the country-level carbon allowances. Some countries, like for instance Ukraine, quickly realized the added value of JI and boosted its development, while in others, like Russia, JI lacked political support and efficient frameworks took time to be established. According to the ERU supply forecasting model developed by CDC Climat Research, Annex I countries are expected to generate up to 356 million ERUs for the first Kyoto commitment period. Around 80% of these credits shall originate from Russia and Ukraine, and up to 70 million shall be generated from countries participating in the EU ETS. Within the EU, JI has been used as a 'frontier mechanism': JI projects mostly explored abatement opportunities not covered by the scheme and, as highlighted by the case of nitrous oxide emissions from the production of nitric acid, played an important role in identifying abatement technologies and providing information to extend the scope of the EU ETS. One of the most complex issues related to JI is the practice of additionality. The cases of France and Ukraine demonstrate that the stakes associated with additionality may differ depending on a country's compliance position. In Ukraine, additionality was not perceived as a significant economic risk due to a

  16. Radio-sensitizing effect of ethyl caffeate on nasopharyngeal ...

    African Journals Online (AJOL)

    3Department of Clinical Laboratory, The 5th People's Hospital of Ji'nan, Ji'nan ... Purpose: To investigate the radio-sensitizing effect of ethyl caffeate (ETF) on naso-pharyngeal ... malignant solid tumors of head and neck which ... Excess irradiation could result in severe side .... protein bands were probed with corresponding.

  17. CO{sub 2} capture and utilization for enhanced oil recovery

    Energy Technology Data Exchange (ETDEWEB)

    Vilhelmsen, P.J.; Well, W. van; Nielsen, Charles [DONG Energy Generation, Fredericia (Denmark); Harrar, W.; Reffstrup, J. [DONG Energy Exploration and Production, Hoersholm (Denmark)

    2007-05-15

    CO{sub 2} is an international theme and the cap-and-trade systems under implementation will lead to significant alterations in the energy market and in the energy system altogether. A possible technical step to reduce atmospheric emissions is CO{sub 2} capture and the utilisation of the CO{sub 2} for Enhanced Oil Recovery (EOR). CO{sub 2} capture is to some extent a know technology but has not yet been optimised and commercialised for power plant utilisation. Correspondingly CO{sub 2} utilisation for EOR is a known method in other areas of the world where the reservoir conditions are different from those of the North Sea. For several years Elsam and Energi E2, part of DONG Energy, have worked on reducing CO{sub 2} emissions through increased efficiency at the coal-fired power plants, and this work has now been extended to also include capture and utilisation of CO{sub 2}. DONG E and P within DONG Energy has started work on the utilisation of CO{sub 2} for EOR at the company's fields in the North Sea. Based on DONG Energy's interest in working through the whole value chain from power plants to EOR utilisation in the North Sea, this paper describes our experience with CO{sub 2} capture at the trial plant CASTOR at Esbjerg power plant and the actual work of investigating and preparing the pilot test of CO{sub 2} for EOR in the North Sea. The paper also illustrates the perspectives of retrofitting the existing fleet of super critical coal-fired power plants close to the North Sea with CO{sub 2} capture and the utilisation of the CO{sub 2} for EOR in the North Sea. DONG Energy's perspective is that CO{sub 2} for EOR can contribute to materialising the vision that the central power plant can be developed into an energy refinery. The development work presented will be carried out in cooperation with leading international players and Danish universities and knowledge centres Technical University of Denmark (DTU), The Danish Geotechnical Institute (GEO) and Geological

  18. Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications

    OpenAIRE

    Wang, Yongzhong; Fan,Zhen; Shao,Lei; Kong,Xiaowei; Hou,Xianjuan; Tian,Dongrui; Sun,Ying; Xiao,Yazhong; Yu,Li

    2016-01-01

    Yongzhong Wang,1 Zhen Fan,2 Lei Shao,3 Xiaowei Kong,1 Xianjuan Hou,1 Dongrui Tian,1 Ying Sun,1 Yazhong Xiao,1 Li Yu4 1School of Life Sciences, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei, People’s Republic of China; 2Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA; 3State Key Laboratory of New Drugs and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, 4Department of Microbiolog...

  19. Wind turbine technology principles and design

    CERN Document Server

    Adaramola, Muyiwa

    2014-01-01

    IntroductionPart I: AerodynamicsWind Turbine Blade Design; Peter J. Schubel and Richard J. CrossleyA Shrouded Wind Turbine Generating High Output Power with Wind-Lens Technology; Yuji Ohya and Takashi KarasudaniEcomoulding of Composite Wind Turbine Blades Using Green Manufacturing RTM Process; Brahim AttafAerodynamic Shape Optimization of a Vertical-Axis Wind Turbine Using Differential Evolution; Travis J. Carrigan, Brian H. Dennis, Zhen X. Han, and Bo P. WangPart II: Generators and Gear Systems

  20. Long-term results of a randomized controlled trial evaluating preoperative chemotherapy in resectable non-small cell lung cancer

    OpenAIRE

    Chen, Zhiwei; Luo, Qingquan; Jian, Hong; Zhou, Zhen; Cheng, Baijun; Lu, Shun; Liao, Meilin

    2013-01-01

    Zhiwei Chen,* Qingquan Luo,* Hong Jian, Zhen Zhou, Baijun Cheng, Shun Lu, Meilin LiaoShanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China *These authors contributed equallyObjective: We aimed to evaluate whether preoperative chemotherapy provides benefits in the survival and prognosis of patients with non-small cell lung cancer (NSCLC) in resectable stages I to IIIA, except T1N0. Methods: In this ra...

  1. 'Poker' association of weekly alternating 5-fluorouracil, irinotecan, bevacizumab and oxaliplatin (FIr-B/FOx) in first line treatment of metastatic colorectal cancer: a phase II study

    International Nuclear Information System (INIS)

    Bruera, Gemma; Ficorella, Corrado; Ricevuto, Enrico; Santomaggio, Alessandra; Cannita, Katia; Baldi, Paola Lanfiuti; Tudini, Marianna; De Galitiis, Federica; Mancini, Maria; Marchetti, Paolo; Antonucci, Adelmo

    2010-01-01

    This phase II study investigated efficacy and safety of weekly alternating Bevacizumab (BEV)/Irinotecan (CPT-11) or Oxaliplatin (OHP) associated to weekly 5-Fluorouracil (5-FU) in first line treatment of metastatic colorectal carcinoma (MCRC). Simon two-step design: delta 20% (p 0 50%, p 1 70%), power 80%, α 5%, β 20%. Projected objective responses (ORR): I step, 8/15 patients (pts); II step 26/43 pts. Schedule: weekly 12 h-timed-flat-infusion/5-FU 900 mg/m 2 , days 1-2, 8-9, 15-16, 22-23; CPT-11 160 mg/m 2 plus BEV 5 mg/kg, days 1,15; OHP at three dose-levels, 60-70-80 mg/m 2 , days 8, 22; every 4 weeks. Fifty consecutive, unselected pts < 75 years were enrolled: median age 63; young-elderly (yE) 24 (48%); liver metastases (LM) 33 pts, 66% Achieved OHP recommended dose, 80 mg/m 2 . ORR 82% intent-to-treat and 84% as-treated analysis. Median progression-free survival 12 months. Equivalent efficacy was obtained in yE pts. Liver metastasectomies were performed in 26% of all pts and in 39% of pts with LM. After a median follow-up of 21 months, median overall survival was 28 months. Cumulative G3-4 toxicities per patient: diarrhea 28%, mucositis 6%, neutropenia 10%, hypertension 2%. They were equivalent in yE pts. Limiting toxicity syndromes (LTS), consisting of the dose-limiting toxicity, associated or not to G2 or limiting toxicities: 44% overall, 46% in yE. Multiple versus single site LTS, respectively: overall, 24% versus 20%; yE pts, 37.5% versus 8%. Poker combination shows high activity and efficacy in first line treatment of MCRC. It increases liver metastasectomies rate and can be safely administered. Osservatorio Nazionale sulla Sperimentazione Clinica dei Medicinali (OsSC) Agenzia Italiana del Farmaco (AIFA) Numero EudraCT 2007-004946-34

  2. Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y

    Directory of Open Access Journals (Sweden)

    Sakaki Yoshiyuki

    2008-10-01

    Full Text Available Abstract Background SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA, but the molecular mechanism of activation in the signalling pathway mediated by phosphatidylinositol 3-kinase (PI3K is unclear. To investigate this mechanism, we compared the gene expression profiles in SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E, each of which show a different phenotype during RA-mediated differentiation. Findings SH-SY5Y-A cells differentiated in the presence of RA, whereas RA-treated SH-SY5Y-E cells required additional treatment with brain-derived neurotrophic factor (BDNF for full differentiation. After exposing cells to a PI3K inhibitor, LY294002, we identified 386 genes and categorised these genes into two clusters dependent on the PI3K signalling pathway during RA-mediated differentiation in SH-SY5Y-A cells. Transcriptional regulation of the gene cluster, including 158 neural genes, was greatly reduced in SK-N-SH cells and partially impaired in SH-SY5Y-E cells, which is consistent with a defect in the neuronal phenotype of these cells. Additional stimulation with BDNF induced a set of neural genes that were down-regulated in RA-treated SH-SY5Y-E cells but were abundant in differentiated SH-SY5Y-A cells. Conclusion We identified gene clusters controlled by PI3K- and TRKB-mediated signalling pathways during the differentiation of two subtypes of SH-SY5Y cells. The TRKB-mediated bypass pathway compensates for impaired neural function generated by defects in several signalling pathways, including PI3K in SH-SY5Y-E cells. Our expression profiling data will be useful for further elucidation of the signal transduction-transcriptional network involving PI3K or TRKB.

  3. Eerder anders as elders: Gerrie Snyman se bydrae in die konteks van die Gereformeerde teologie

    Directory of Open Access Journals (Sweden)

    Hans J.M. van Deventer

    2010-03-01

    Full Text Available Rather different than elsewhere: Gerrie Snyman�s contribution in the context of Reformed theology Prof Gerrie Snyman�s book Om die Bybel anders te lees: �n etiek van Bybellees (2007 attracted considerable attention in Afrikaans-speaking reformed circles in South Africa. In this article, some of the responses to and reviews of the book are studied in order to assess the publication�s impact. Moreover, the article aims to determine whether the book will contribute to future reflections and discussions on the use of the Bible in this context. It is concluded that the preferred method of interpretation in the Reformed Church in South Africa calls for a thorough revision. The so-called �grammatical-historical method� of interpretation can no longer be regarded as the most appropriate and sole �Reformed method� of interpretation.�--- Abstract translated into Sipedi ---Go fapana le t�e dingwe: seabe sa Gerrie Snyman go teologie ya RefomoPuku ya Profesa Gerrie Snyman, Om die Bybel anders te lees: �n Etiek van Bybellees (2007, e gogile �edi ye kgolo ya maloko a kereke ya Refomo mo Afrika-Borwa(RCSA/GKSA. Mo pampiring ye re ithuta t�e dingwe t�a dikarabo le ditshekatsheko t�a puku ye go ela khuet�o ya yona. Go feta fao, pampiri ye e nepile go bona ge e ba puku ye e tlo ba le seabe go dikakanyo le dipoledi�ano mabapi le t�homi�o ya Beibele ditabeng t�a mohuta wo. Re ruma ka go re, mokgwa wa tshekatsheko ya Bibele wa Kereke ya Refomo mo Afrika-Borwa o hloka go lekodi�i�wa le go boelet�wa. Mokgwa wa go hlatholla Bibele ka go sekaseka popopolelo(gramatika le histori ya tlholego ya yona, o ka se sa t�ewa e le wona wa maleba o nno�i wa tshekatsheko goba go ba wona �Mokgwa wa Refomo� wa go fetleka Bibele.--- End of translation ---

  4. Interaction effect of job insecurity and role ambiguity on psychological distress in Japanese employees: a cross-sectional study.

    Science.gov (United States)

    Inoue, Akiomi; Kawakami, Norito; Eguchi, Hisashi; Tsutsumi, Akizumi

    2018-05-01

    We examined the interaction effect of job insecurity (JI) and role ambiguity (RA) on psychological distress in Japanese employees. Overall, 2184 male and 805 female employees from two factories of a manufacturing company in Japan completed a self-administered questionnaire comprising the scales measuring JI (Job Content Questionnaire), RA (National Institute for Occupational Safety and Health Generic Job Stress Questionnaire), psychological distress (K6 scale), and potential confounders (i.e., age, education, family size, occupational class, and work shift). Taking psychological distress as a dependent variable, hierarchical multiple regression analyses were conducted by gender and employment status (i.e., permanent and non-permanent employees). An interaction term of JI × RA was included in the model. After adjusting for potential confounders, the main effects of JI and RA on psychological distress were significant regardless of gender or employment status. Furthermore, the significant interaction effect of JI × RA on psychological distress was observed among permanent male employees (β = 0.053, p = 0.010). Post hoc simple slope analyses showed that the simple slope of JI was greater at higher levels of RA (i.e., one standard deviation [SD] above the mean) (β = 0.300, p female employees. The present study suggests that higher levels of RA strengthen the association of JI with psychological distress, at least among Japanese permanent male employees.

  5. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. HARI JI SINGH. Articles written in Journal of Chemical Sciences. Volume 123 Issue 5 September 2011 pp 733-741. Computational study on decomposition kinetics of CH3CFClO radical · Hari Ji Singh Bhupesh Kumar Mishra · More Details Abstract Fulltext PDF. The present ...

  6. Effect of Zhen-wu decoction on chronic heart failure in rats | Liu ...

    African Journals Online (AJOL)

    Results: Compared with normal control group, ZWD group showed decreased arterial systolic pressure (SBP, 89.16 ± 17.27 mmHg), diastolic pressure (DBP, 72.54 ± 22.36 mmHg), mean arterial pressure (MAP, 72.64 ± 11.87 mmHg), heart rate (HR, 368.25 ± 39.12 beats/min), left ventricular systolic peak (LVSP, 105.27 ...

  7. Retraction RETRACTION of "Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population" by H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu - Genet. Mol. Res. 15 (2): gmr.15025866 DOI: http://dx.doi.org/10.4238/gmr.15025866.

    Science.gov (United States)

    Zhao, H; Zhang, H W; Zhang, T; Gu, X M

    2016-10-07

    The retracted article is: Zhao H, Zhang HW, Zhang T and Gu XM (2016). Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population. Genet. Mol. Res. 15: gmr.15025866. Two major concerns were found in this article. Firstly, it was found to be substantially equal to the article "Tumor necrosis factor-alpha gene -308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese population" published in the Diagnostic Pathology Diagnostic Pathology (2014) 9: 199, by Feng et al.; licensee BioMed Central. 2014 - DOI: 10.1186/s13000-014-0199-3. Secondly, the authors do not discuss limitations of their approaches in the discussion. The discussion is largely an elaboration of the literature in the introduction part. However, even in that context, the discussion does not appropriately review the literature and there are frequent references to conclusions that are not supported by the cited literature. The GMR editorial staff was alerted and after a thorough investigation, there is strong reason to believe that the peer review process was failure. Also, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). The authors and their institutions were advised of this serious breach of ethics.

  8. Zhao et al. (2017) Chem. Geol. v. 474 p.1

    Data.gov (United States)

    U.S. Environmental Protection Agency — The dataset provides information on chromium concentrations extracted from rock samples collected at the Garfield SF site in New Jersey (USA). The data are discussed...

  9. The vaccines for Bovine Herpesvirus Type 1: A review | Zhao ...

    African Journals Online (AJOL)

    Bovine herpesvirus type 1 (BoHV-1) is the pathogen of Infectious Bovine Rhinothracheitis (IBR) disease, causing great economic losses in the livestock industry. Vaccine is a powerful means to control the virus. Here, the review described the currently available knowledge regarding to the advance in the field of BoHV-1 ...

  10. MUON DETECTORS: CSC

    CERN Document Server

    R. Breedon

    2010-01-01

    Toward the end of last year, a few water leaks, one of them severe, were discovered in the endcap cooling system on the YE1 disks that not only services the cathode strip chambers, but also the endcap resistive plate chambers, electromagnetic calorimeter, and disks. The problem was traced to a bushing adaptor present on each return line that in some cases had been over-tightened. There were close to 400 such bushings on all the endcap disks that could potentially cause a leak. Most of these are inaccessible to fix or valve off when CMS is closed, so a future leak could require shutting down an entire disk. It was therefore decided to open CMS during the December shutdown and replace all the bushing assemblies on the YE1 disks with swivel fittings that do  not have this potential problem. From 8 to 22 January, 6 technicians from the Polish ZEC company and 2 engineers from the Physical Sciences Laboratory in Wisconsin not only made the replacements on YE1, but on all the other endcap disks as well. ...

  11. Open fermentative production of L-lactic acid with high optical purity by thermophilic Bacillus coagulans using excess sludge as nutrient.

    Science.gov (United States)

    Ma, Kedong; Maeda, Toshinari; You, Huiyan; Shirai, Yoshihito

    2014-01-01

    The development of a low-cost polymer-grade L-lactic acid production process was achieved in this study. Excess sludge hydrolyzate (ESH) was chosen as nutrient source for the objective of reducing nutrient cost in lactic acid production. 1% of ESH had high performance in lactic acid production relative to 2g/l yeast extract (YE) while the production cost of ESH was much lower than that of YE, indicating ESH was a promising substitute of YE. By employing a thermophilic strain of Bacillus coagulans (NBRC 12583), non-sterilized batch and repeated batch L-lactic acid fermentation was successfully performed, and the optical purity of L-lactic acid accumulated was more than 99%. Moreover, the factors associated with cell growth and lactic acid fermentation was investigated through a two-stage lactic acid production strategy. Oxygen played an important role in cell growth, and the optimal condition for cell growth and fermentation was pH 7.0 and 50°C. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. An Experimental Validated Control Strategy of Maglev Vehicle-Bridge Self-Excited Vibration

    Directory of Open Access Journals (Sweden)

    Lianchun Wang

    2017-01-01

    Full Text Available This study discusses an experimentally validated control strategy of maglev vehicle-bridge vibration, which degrades the stability of the suspension control, deteriorates the ride comfort, and limits the cost of the magnetic levitation system. First, a comparison between the current-loop and magnetic flux feedback is carried out and a minimum model including flexible bridge and electromagnetic levitation system is proposed. Then, advantages and disadvantages of the traditional feedback architecture with the displacement feedback of electromagnet yE and bridge yB in pairs are explored. The results indicate that removing the feedback of the bridge’s displacement yB from the pairs (yE − yB measured by the eddy-current sensor is beneficial for the passivity of the levitation system and the control of the self-excited vibration. In this situation, the signal acquisition of the electromagnet’s displacement yE is discussed for the engineering application. Finally, to validate the effectiveness of the aforementioned control strategy, numerical validations are carried out and the experimental data are provided and analyzed.

  13. The Impact of Job Involvement on Emotional Labor to Customer-Oriented Behavior: An Empirical Study of Hospital Nurses.

    Science.gov (United States)

    Wang, Mei-Ling; Chang, Shu-Chen

    2016-06-01

    Healthcare is a profession that requires a high level of emotional labor (EL). Nurses provide frontline services in hospitals and thus typically experience high levels of EL. The quality of services that nurses provide impacts on how patients evaluate the service quality of hospitals. The aim of this study is to explore the relationships among EL, job involvement (JI), and customer-oriented behavior (COB) in the context of the nursing profession. The participants in this study were nurses at eight hospitals, all located in Taiwan. This study used a self-reporting questionnaire. Research data were gathered at two discrete periods (A and B). Questionnaire A collected data on EL and JI, and Questionnaire B collected data on COB. Five hundred questionnaires were sent out to qualified participants, and 472 valid questionnaires were returned. Hierarchical regression analysis was used to test the hypotheses. The expression of positive emotion (EPE) and the suppression of negative emotion (SNE) were found to positively affect the patient-oriented COB. Furthermore, the EPE was found to positively affect the task-oriented COB. In terms of the moderating effect of JI, JI was found to relate positively to the EPE, patient-oriented COB, and task-oriented COB. In addition, higher values of JI were found to weaken the relationship between the SNE and the task-oriented COB. It has become an increasingly popular practice for hospital organizations to work to promote the COB of their nursing staffs. The results of this study prove empirically that a relationship exists among EL, COB, and JI in nurses. This study contributes to the related literature, enhances the knowledge of hospital and nursing administrators with regard to EL and COB, and offers a reference for hospital managers who are responsible for designing and executing multidisciplinary programs and for managing hospital-based human resources.

  14. Carbon Taxes and Joint Implementation. An Applied General Equilibrium Analysis for Germany and India

    Energy Technology Data Exchange (ETDEWEB)

    Boehringer, C.; Loeschel, A. [Centre for European Economic Research ZEW, Mannheim (Germany); Conrad, K. [Department of Economics, Mannheim University, Mannheim (Germany)

    2003-01-01

    Germany has committed itself to reducing its carbon emissions by 25% in 2005 as compared to 1990 emission levels. To achieve this goal, the government has recently launched an environmental tax reform which entails a continuous increase in energy taxes in conjunction with a revenue-neutral cut in non-wage labor costs. This policy is supposed to yield a double dividend, reducing both, the problem of global warming and high unemployment rates. In addition to domestic actions, international treaties on climate protection allow for the supplementary use of flexible instruments to exploit cheaper emission reduction possibilities elsewhere. One concrete option for Germany would be to enter joint implementation (JI) with developing countries such as India where Germany pays emission reduction abroad rather than meeting its reduction target solely by domestic action. In this paper, we investigate whether an environmental tax reform cum JI provides employment and overall efficiency gains as compared to an environmental tax reform stand-alone. We address this question in the framework of a large-scale general equilibrium model for Germany and India where Germany may undertake JI with the Indian electricity sector. Our main finding is that JI offsets largely the adverse effects of carbon emission constraints on the German economy. JI significantly lowers the level of carbon taxes and thus reduces the total costs of abatement as well as negative effects on labor demand. In addition, JI triggers direct investment demand for energy efficient power plants produced in Germany. This provides positive employment effects and additional income for Germany. For India, joint implementation equips its electricity industry with scarce capital goods leading to a more efficient power production with lower electricity prices for the economy and substantial welfare gains.

  15. Case Study Evaluating Just-In-Time Teaching and Peer Instruction Using Clickers in a Quantum Mechanics Course

    Science.gov (United States)

    Sayer, Ryan; Marshman, Emily; Singh, Chandralekha

    2016-01-01

    Just-in-Time Teaching (JiTT) is an instructional strategy involving feedback from students on prelecture activities in order to design in-class activities to build on the continuing feedback from students. We investigate the effectiveness of a JiTT approach, which included in-class concept tests using clickers in an upper-division quantum…

  16. Adopting Just-in-Time Teaching in the Context of an Elementary Science Education Methodology Course

    Science.gov (United States)

    Osmond, Pamela; Goodnough, Karen

    2011-01-01

    In this self-study, Pamela, a new science teacher educator, adopted Just-in-Time Teaching (JiTT) in the context of an elementary science education methodology course. JiTT is a teaching and learning strategy involving interaction between web-based study assignments and face-to-face class sessions. Students respond electronically to web-based…

  17. Dependent of electrical resistivity of thin wire on magnetic field and temperature; Vabastegi-ye moghavemat-e elekteriki-ye simha-ye barik be meidan-e meghnatisi va dama

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghi, E [Yasouj University, Physics Department, Yasouj(Iran, Islamic Republic of); Zare, M [Shiraz Payam Noor University, shiraz(Iran, Islamic Republic of)

    2006-04-01

    Variation of electrical resistivity of Bismuth nano wire versus magnetic field the and temperature are considered. We study the size effect and surface scattering of the carrier in thin wire for systems with ellipsoidal Fermi surfaces. Results are in good agreement with experimental points.

  18. The interactive learning toolkit: technology and the classroom

    Science.gov (United States)

    Lukoff, Brian; Tucker, Laura

    2011-04-01

    Peer Instruction (PI) and Just-in-Time-Teaching (JiTT) have been shown to increase both students' conceptual understanding and problem-solving skills. However, the time investment for the instructor to prepare appropriate conceptual questions and manage student JiTT responses is one of the main implementation hurdles. To overcome this we have developed the Interactive Learning Toolkit (ILT), a course management system specifically designed to support PI and JiTT. We are working to integrate the ILT with a fully interactive classroom system where students can use their laptops and smartphones to respond to ConcepTests in class. The goal is to use technology to engage students in conceptual thinking both in and out of the classroom.

  19. Mechanical and magnetic properties of semi-Heusler/light-metal composites consolidated by spark plasma sintering

    Czech Academy of Sciences Publication Activity Database

    Koller, M.; Chráska, Tomáš; Cinert, Jakub; Heczko, Oleg; Kopeček, Jaromír; Landa, Michal; Mušálek, Radek; Rameš, Michal; Seiner, Hanuš; Stráský, J.; Janeček, M.

    2017-01-01

    Roč. 126, July (2017), s. 351-357 ISSN 0264-1275 R&D Projects: GA ČR GB14-36566G Institutional support: RVO:61389021 ; RVO:68378271 ; RVO:61388998 Keywords : Metal–metal composites * Spark plasma sintering * Light metals * Ferromagnetic alloys * Mechanical properties Subject RIV: JI - Composite Materials; JI - Composite Materials (FZU-D); JI - Composite Materials (UT-L) OBOR OECD: Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics (FZU-D); Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics (UT-L) Impact factor: 4.364, year: 2016 https://www.sciencedirect.com/science/ article /pii/S0264127517303842?via%3Dih

  20. Just-in-Time Teaching

    Science.gov (United States)

    Novak, Gregor M.

    2011-01-01

    This chapter provides an overview and implementation guidelines of Just-in-Time Teaching (JiTT), an interactive engagement pedagogy used across disciplines and across the academy, now in its fourteenth year. The heart of JiTT pedagogy is Web-based pre-instruction assignments called warm-ups, with some colorful local variations, such as GeoBytes in…

  1. QTL analysis of kernel soluble sugar content in supersweet corn | Qi ...

    African Journals Online (AJOL)

    sweet corn population consisting of 208 F2 individuals from the cross Ji557 (sh2) × Ji165 (sh2). Density of the linkage groups varied from 2.2 cM to 65.3 cM, with an average of 13.0 2 cM between two adjacent markers. The map covered 1470.9 cM ...

  2. High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis

    OpenAIRE

    Yuan, Zhong-Yu; Luo, Rong-Zhen; Peng, Rou-Jun; Wang, Shu-Sen; Xue, Cong

    2014-01-01

    Zhong-Yu Yuan,1–3* Rong-Zhen Luo,1,2,4,* Rou-Jun Peng,1–3 Shu-Sen Wang,1–3 Cong Xue1–3 1State Key Laboratory of Oncology in South China, 2Collaborative Innovation Center for Cancer Medicine, 3Departments of Medical Oncology, Sun Yat-Sen University Cancer Center, 4Departments of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China  *These authors contributed equally to this work Background: Triple-ne...

  3. Apple Role Through Fair Labour Association (FLA) in Order to Fixing Foxconn's Sweatshop in China

    OpenAIRE

    Sari, Sarah Puspa

    2014-01-01

    In 2010, there is several news about suicides at Foxconn's factory in ShenZhen, China, a plant that assembles iPhones, iPods, and iPads for Apple. In order to fix this sweatshop practice in its chain, Apple make affliliateswith independent labor monitoring organizations engaged by the Fair Labour Association (FLA) as participating company. In FLA charter stated that the member should adopted a "Workplace Code of Conduct". The FLA Workplace Code of Conduct defines labor standards that aim to a...

  4. AcEST: DK944801 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 1. 5' end sequence. DK944801 - Show DK944801 Clone id YMU02A01NGRL0007_D21 Library YMU02 Length 485 Definiti...on Adiantum capillus-veneris mRNA. clone: YMU02A01NGRL0007_D21. 5' end sequence. Accession DK944801 Tissue t... 25:3389-3402. Query= DK944801|Adiantum capillus-veneris mRNA, clone: YMU02A01NGRL0007_D21, 5' (472 letters)...lfolobus solfata... 32 1.8 sp|O13801|YE04_SCHPO Uncharacterized RNA-binding prote...DDPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGALAIAYALKY 129 >sp|O13801|YE04_SCHPO Uncharacterized RNA-binding pro

  5. A generalization of Sachdev-Ye-Kitaev

    Energy Technology Data Exchange (ETDEWEB)

    Gross, David J.; Rosenhaus, Vladimir [Kavli Institute for Theoretical Physics, University of California,Santa Barbara, CA 93106 (United States)

    2017-02-17

    The SYK model: fermions with a q-body, Gaussian-random, all-to-all interaction, is the first of a fascinating new class of solvable large N models. We generalize SYK to include f flavors of fermions, each occupying N{sub a} sites and appearing with a q{sub a} order in the interaction. Like SYK, this entire class of models generically has an infrared fixed point. We compute the infrared dimensions of the fermions, and the spectrum of singlet bilinear operators. We show that there is always a dimension-two operator in the spectrum, which implies that, like in SYK, there is breaking of conformal invariance and maximal chaos in the infrared four-point function of the generalized model. After a disorder average, the generalized model has a global O(N{sub 1})×O(N{sub 2})×…×O(N{sub f}) symmetry: a subgroup of the O(N) symmetry of SYK; thereby giving a richer spectrum. We also elucidate aspects of the large q limit and the OPE, and solve q=2 SYK at finite N.

  6. Joint implementation as an instrument for the market introduction of solar thermal power plants; Joint Implementation als Instrument zur Markteinfuehrung Solarthermischer Kraftwerke

    Energy Technology Data Exchange (ETDEWEB)

    Trieb, F.; Nitsch, J.; Fischedick, M.; Luhmann, H.J.

    1997-12-31

    The term ``Joint implementation`` (JI) describes an international manageable tool to reduce the global emission of greenhouse gases, especially carbondioxide (CO{sub 2}). The principle idea of JI is based on the insight that it is of no importance where on earth CO{sub 2} is emitted or conserved. Hence it is only recommendable from the economic point of view to make investments at those locations where the highest conservation can be achieved by an equal use of capital. JI would help industrial countries to fulfil cost-effectively part of their obligation to reduce CO{sub 2} by higher investments in other countries (e.g. for the improvement of energy efficiency). Solar power plants meet all criteria of a successful JI-project approach and show several positive ecological and socio-economic side effects, which can lead in the medium term to environmentally friendly and economic electricity supply. One precondition is that the phase of market introduction will be soon followed by a phase of mass production which fully uses the present potential of this technology to reduce costs by approx. 50 %. The project THESUS on Crete is an important step towards market introduction and shows the importance of solar thermal power plants for climate protection. Above all it is an important European step towards a long-term energy supply. (orig./AKF) [Deutsch] Der Begriff `Joint Implementation` (JI) beinhaltet ein international handhabbares Instrumentarium zur Minderung des globalen Ausstosses von Treibhausgasen, insbesondere des Kohlendioxids (CO{sub 2}). Die Grundidee von JI beruht auf der Erkenntnis, dass es ohne Belang ist, an welcher Stelle der Erdoberflaeche CO{sub 2} emitiert oder eingespart wird. Aus oekonomischer Sichtweise liegt es daher nahe, Investitionen dort vorzunehmen, wo bei gleichem Kapitaleinsatz die groessten Einsparungen erzielt werden koennen. Mit JI koennten die Industrielaender einen Teil ihrer Verpflichtungen zur CO{sub 2}-Minderung durch verstaerkte

  7. Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

    Directory of Open Access Journals (Sweden)

    Lee HJ

    2015-12-01

    Full Text Available Hyeong Jin Lee,1,* Bongjin Lee,2,* June Dong Park,2 Hyung Joo Jeong,2 Yu Hyeon Choi,2 Hee Young Ju,1 Che Ry Hong,1 Ji Won Lee,1 Hyery Kim,1 Dong In Suh,3 Kyung Duk Park,1 Hyoung Jin Kang,1 Hee Young Shin,1 Hyo Seop Ahn1 1Department of Pediatrics, Cancer Research Institute, 2Division of Pediatric Intensive Care, Department of Pediatrics, 3Division of Pulmonology, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea *These authors contributed equally to this work Purpose: Although few adverse effects have been reported for itraconazole, a widely used antifungal therapy for febrile neutropenia, we found intravenous (IV itraconazole to be associated with serious cases of blood pressure (BP drop. We therefore evaluated the incidence and risk factors for BP drop during IV administration of the drug.Materials and methods: We reviewed the medical records of children with hemato-oncologic disease who were treated with IV itraconazole from January 2012 to December 2013. By analyzing systolic BP (SBP measurements made from 4 hours before through to 4 hours after itraconazole administration, we evaluated the changes in SBP and the risk factors for an SBP drop, especially clinically meaningful (≥20% drops.Results: Itraconazole was administered 2,627 times to 180 patients. The SBP during the 4 hours following itraconazole administration was lower than during the 4 hours before administration (104 [53.0–160.33 mmHg] versus 105 [59.8–148.3 mmHg]; P<0.001. The decrease in SBP was associated with the application of continuous renal replacement therapy (CRRT (P=0.012 and the use of inotropic (P=0.005 and hypotensive drugs (P=0.021. A clinically meaningful SBP drop was seen in 5.37% (141 out of 2,627 of the administrations, and the use of inotropics (odds ratio [OR] 6.70, 95% confidence interval [CI] 3.22–13.92; P<0.001, reducing the dose of inotropics (OR 8.08; 95% CI 1.39–46.94; P=0

  8. Retraction RETRACTION of "Methylation of the RASSFIA promoter in breast cancer" by Y. Ji, H.H. Jin, M.D. Wang, W.X. Cao, J.L. Bao - Genet. Mol. Res. 15 (2): gmr.15028261 (2016) - DOI: 10.4238/gmr.15028261.

    Science.gov (United States)

    Ji, Y; Jin, H H; Wang, M D; Cao, W X; Bao, J L

    2016-10-07

    The retracted article is: Ji Y, Jin HH, Wang MD, Cao WX, et al. (2016). Methylation of the RASSFIA promoter in breast cancer. Genet. Mol. Res. 15: gmr.15028261. There are significant parts of this article (particularly, in the discussion section) that are copied from "Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome", by Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu, published in BMC Cancer 2012; 12: 243. DOI: 10.1186/1471-2407-12-243. The first paragraphs of both discussions are identical. This is concerning. The abstract and introduction sections have much of their text plagiarized. Overall, there is high plagiarism detected. The GMR editorial staff was alerted and after a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract the article in accordance with the recommendations of the Committee on Publication Ethics (COPE). The authors and their institutions were advised of this serious breach of ethics.

  9. Simulation of HEAO 3 Background

    Science.gov (United States)

    2007-01-01

    i i o iipp i i o iinn VdE A NaEEf VdE A NaEEfprod ji ji j R where i is a stable isotope in volume V, ai is its fractional abundance, i the...National Nuclear Data Center (NNDC), Brookhaven National Laboratory, Brookhaven, NY. [10] W. Nelson et al., ”The EGS4 code system ”, SLAC-Report-265

  10. [A Study on the quotations in the Wu xing da yi (The Gist of Five Phases) cited from Nei jing (Inner Canon)].

    Science.gov (United States)

    Wang, Zheng-Shan; Zhang, Qi-Cheng

    2013-07-01

    In the Wu xing da yi (The Gist of Five Phases), written by Xiao Ji of the Sui Dynasty, there were 9 quotations cited from Huang di nei jing (Inner Canon of Huangdi). By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages.

  11. Featured Image: Simulating Planetary Gaps

    Science.gov (United States)

    Kohler, Susanna

    2017-03-01

    The authors model of howthe above disk would look as we observe it in a scattered-light image. The morphology of the gap can be used to estimate the mass of the planet that caused it. [Dong Fung 2017]The above image from a computer simulation reveals the dust structure of a protoplanetary disk (with the star obscured in the center) as a newly formed planet orbits within it. A recent study by Ruobing Dong (Steward Observatory, University of Arizona) and Jeffrey Fung (University of California, Berkeley) examines how we can determine mass of such a planet based on our observations of the gap that the planet opens in the disk as it orbits. The authors models help us to better understand how our observations of gaps might change if the disk is inclined relative to our line of sight, and how we can still constrain the mass of the gap-opening planet and the viscosity of the disk from the scattered-light images we have recently begun to obtain of distant protoplanetary disks. For more information, check out the paper below!CitationRuobing Dong () and Jeffrey Fung () 2017 ApJ 835 146. doi:10.3847/1538-4357/835/2/146

  12. Assessment of Forest Degradation in Vietnam Using Landsat Time Series Data

    Directory of Open Access Journals (Sweden)

    James E. Vogelmann

    2017-07-01

    Full Text Available Landsat time series data were used to characterize forest degradation in Lam Dong Province, Vietnam. We conducted three types of image change analyses using Landsat time series data to characterize the land cover changes. Our analyses concentrated on the timeframe of 1973–2014, with much emphasis on the latter part of that range. We conducted a field trip through Lam Dong Province to develop a better understanding of the ground conditions of the region, during which we obtained many photographs of representative forest sites with Global Positioning System locations to assist us in our image interpretations. High-resolution Google Earth imagery and Landsat data of the region were used to validate results. In general, our analyses indicated that many land-use changes have occurred throughout Lam Dong Province, including gradual forest to non-forest transitions. Recent changes are most marked along the relatively narrow interfaces between agricultural and forest areas that occur towards the boundaries of the province. One important observation is that the most highly protected national reserves in the region have not changed much over the entire Landsat timeframe (1972–present. Spectral changes within these regions have not occurred at the same levels as those areas adjacent to the reserves.

  13. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

    Directory of Open Access Journals (Sweden)

    Chen ZQ

    2012-02-01

    Full Text Available Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaBackground: Indirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS was developed to improve the oral bioavailability of indirubin.Methods: A prototype S-SMEDDS was designed using solubility studies and phase diagram construction. Precipitation inhibitors were selected from hydrophilic polymers according to their crystallization-inhibiting capacity through in vitro precipitation tests. In vitro release of indirubin from S-SMEDDS was examined to investigate its likely release behavior in vivo. The in vivo bioavailability of indirubin from S-SMEDDS and from SMEDDS was compared in rats.Results: The prototype formulation of S-SMEDDS comprised Maisine™ 35-1:Cremophor® EL:Transcutol® P (15:40:45, w/w/w. Polyvinylpyrrolidone K17, a hydrophilic polymer, was used as a precipitation inhibitor based on its better crystallization-inhibiting capacity compared with polyethylene glycol 4000 and hydroxypropyl methylcellulose. In vitro release analysis showed more rapid drug release from S-SMEDDS than from SMEDDS. In vivo bioavailability analysis in rats indicated that improved oral absorption was achieved and that the relative bioavailability of S-SMEDDS was 129.5% compared with SMEDDS.Conclusion: The novel S-SMEDDS developed in this study increased the dissolution rate and improved the oral bioavailability of indirubin in rats. The results suggest that S-SMEDDS is a superior means of oral delivery of indirubin.Keywords: supersaturatable self-microemulsifying drug delivery system, indirubin, bioavailability, oral drug delivery, hydrophilic polymer

  14. Emission projections 2008-2012 versus national allocation plans II

    International Nuclear Information System (INIS)

    Neuhoff, Karsten; Ferrario, Federico; Grubb, Michael; Gabel, Etienne; Keats, Kim

    2006-01-01

    We compare the national allocation plans (NAPs), proposed and submitted by EU Member States as of October 2006, with our estimations for CO 2 emissions by the installations covered by these NAPs. The collective allocations proposed under phase II NAPs exceed the historic trend of emissions extrapolated forward. Using our projections we find, depending on uncertainty in fuel prices, economic growth rates, performance of the non-power sector and CDM/JI availability, a 15% chance of a 'dead market' with emissions below cap even at zero prices. With an expected inflow of committed CDM/JI credits of 100 MtCO 2 /year, allowance supply will exceed demand in 50% of cases without any carbon price, and in 80% of our euros20/tCO 2 scenarios. Banking of allowances towards post-2012 conditions could create additional demand, but this is difficult to anticipate and conditional on policy evolution. The proposed phase II NAPs would result in low prices and only small volumes of CDM/JI would enter the EU ETS. CDM/JI would almost exclusively be public-sector funded, placing the cost of Kyoto compliance entirely upon governments. (Author)

  15. An explanation for the universal 3.5 power-law observed in currency markets

    Directory of Open Access Journals (Sweden)

    Nicholas A. Johnson

    Full Text Available We present a mathematical theory to explain a recent empirical finding in the Physics literature (Zhao et al., 2013 in which the distributions of waiting-times between discrete events were found to exhibit power-law tails with an apparent universal exponent: α∼3.5. This new theory provides the first ever qualitative and quantitative explanation of Zhao et al.’s surprising finding. It also provides a mechanistic description of the origin of the observed universality, assigning its cause to the emergence of dynamical feedback processes between evolving clusters of like-minded agents. Keywords: Complex systems, Econophysics, Collective, Power law

  16. Hepatitis E Virus Genotype 4 Sequences Detected in Sewage from Treatment Plants of China

    OpenAIRE

    Li, Heng; Li, Wei; She, Ruiping; Yu, Liang; Wu, Qiaoxing; Yang, Jingling; Hu, Fengjiao; Soomro, Majid Hussain; Shi, Ruihan; Hao, Wenzhuo; Zhao, Yue; Mao, Jingjing

    2017-01-01

    The aim of this study was to investigate the occurrence of hepatitis E virus (HEV) in sewage samples in Shen Zhen, China. Sewage samples were collected from 152 sewage plants including livestock sewage, domestic sewage and treated sewage from May to July of 2015. Two of 152 samples were HEV positive (1.32%) from the livestock sewage plants. Partial ORF2 fragments of HEV were sequenced and a phylogenetic tree was constructed using MEGA5.1. Blast and phylogenetic analyses showed that both of th...

  17. Chemistries for Protection and Decontamination

    Science.gov (United States)

    2008-03-01

    t i o n Measurement of Oxygen Uptake, Supported Catalyst and CEES in Solvent-Free System TDA R e s e a r c h Tests with HD • At CUBRC (Buffalo...dual gas burettes for HD tests at CUBRC . The dual burette on the left was connected to a flask with the catalyst and HD (and to an empty flask as a...Hill, Zhen Luo, Daniel Hillesheim • ECBC: Larry Procell • CUBRC : Meg Stapleton, Rich Fitzpatrick • Battelle: John Ontiveros, Walter Miller • ARO

  18. TECHNICAL COORDINATION,SCHEDULE AND INTEGRATION

    CERN Document Server

    A. Ball

    A pivotal milestone in CMS underground installation will be reached during this CMS week when the 1920 ton central wheel (YB0) of the iron yoke is lowered into the experimental cavern on Wednesday 28 February. This milestone will be reached on the on the date planned due to the hard work and dedication of many people, on the surface, underground and at supporting sites. Details of the programme for 28 February, visit opportunities and progress updates, can be found on the TC web pages on iCMS. http://cms.cern.ch/iCMS/jsp/page.jsp?mode=cms&ac-tion=url&urlkey=CMS_TC Heavy lowering The build-up to the above event started shortly after the December CMS week, when the YE+2 endcap disk was safely lowered into the cavern, followed by the YE+1 on January 9. The lowering of YE+1 was the most complicated so far because, due to the calorimetry nose, the centre of gravity lies outside the plane of the disk. However, after 10 hours it touched-down safely without any problems. On Jan. 19 the first barrel wheel ...

  19. Wrestling: An Integral Part of Iranian Fighting Arts

    Directory of Open Access Journals (Sweden)

    Manouchehr Moshtagh Khorasani

    2012-07-01

    Full Text Available Wrestling played and has been playing a very important role in Iranian cultural heritage. First, the present article discusses the terms and different uses of wrestling techniques be it in unarmed duels or in combination with weapons. Then, three relevant manuscripts will be analyzed such as an untitled wrestling manuscript by an anonymous author from the period of Šāh Esmāil Safavid (1502-1524 C.E., the manuscript Tumār-e Puryā-ye Vali also written by an anonymous author during the Safavid period (1502-1722 C.E. and the work by a famous poet named Mirnejāt with the title Masnavi-ye Golkošti-ye Mirnejāt that was written towards the end of the period of Šāh Soleymān Safavid (1666-1694 C.E. or the beginning of the period of Šāh Soltān Hosseyn Safavid (1694-1722 C.E.. Based on some terms and descriptions of the techniques found in these manuscripts, it is possible to appreciate how traditional forms of wrestling in Iran have preserved some of these techniques.

  20. Progress on CMS detector lowering

    CERN Multimedia

    2006-01-01

    It was an amazing engineering challenge - the lowering of the first hugeendcap disc (YE+3) of the CMS detector slowly and carefully 100 metres underground. The spectacular descent took place on 30 November and was documented by a film crew from Reuters news group. The uniquely shaped slice is 16 m high, about 50 cm thick, and weighs 400 tonnes. It is one of 15 sections that make up the complete CMS detector. The solid steel structure of the disc forms part of the magnet return yoke and is equipped on both sides with muon chambers. A special gantry crane lowered the element, with just 20 cm of leeway between the edges of the detector and the walls of the shaft! On 12 December, a further section of the detector (YE+2) containing the cathode strip chamber made the 10-hour journey underground. This piece is 16 m high and weighs 880 tonnes. There are now four sections of the detector in the experimental cavern, with a further 11 to follow. The endcap disc YE+3 (seen in the foreground) begins its journey down the ...