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Sample records for zeta potential analysis

  1. Wettability Studies Using Zeta Potential Measurements

    Directory of Open Access Journals (Sweden)

    Ghada Bassioni

    2015-01-01

    Full Text Available Wettability studies have been carried out on reservoir rocks using different techniques such as the Amott-Harvey method, the USBM method, and the contact angle method, all with limitations. In this study, the wettability is studied by discussing the surface charge using zeta potential measurements. The study relies on the finding that carbonated reservoir rocks, consisting of CaCO3 mainly, are positively charged and their surface has the potential to adsorb significant quantities of anions. Moreover, heavy fractions such as asphaltenes are reported to remain afloat depending on dispersive forces present in the oil and its various fractions. Experiments are carried out on aqueous limestone suspension with the addition of crude oil. The experiment is repeated with the use of polymeric inhibitors, A and B. The zeta potential is found to alter depending on the sequence of polymeric inhibitor in oil/water addition. The inhibitor is found to adsorb on the limestone surface, with a net negative charge, causing repulsion between crude oil and the inhibitor and, hence, preventing the deposition of heavy fractions and particularly asphaltenes. This study gives a comprehensive insight on the mechanism of polymeric inhibitor interaction with the surface and the effect of wettability on its performance.

  2. Zeta potential in colloid science principles and applications

    CERN Document Server

    Hunter, Robert J; Rowell, R L

    2013-01-01

    Zeta Potential in Colloid Science: Principles and Applications covers the concept of the zeta potential in colloid chemical theory. The book discusses the charge and potential distribution at interfaces; the calculation of the zeta potential; and the experimental techniques used in the measurement of electrokinetic parameters. The text also describes the electroviscous and viscoelectric effects; applications of the zeta potential to areas of colloid science; and the influence of simple inorganic ions or more complex adsorbates on zeta potential. Physical chemists and people involved in the stu

  3. Zeta-potential of fouled thin film composite membrane

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, K.; Hachisuka, H.; Nakamura, T. [Nitto denko Corp., Ibaraki, (Japan); Kimura, S. [Kogakuin University, Tokyo (Japan). Dept. of Environ. Chemical Engineering; Ueyama, K. [Osaka University, Osaka (Japan). Dept. of Chemical Engineering

    1999-10-01

    The surface zeta-potential of a cross-linked polyamide thin film composite reverse osmosis membrane was measured using an electrophoresis method. It was confirmed that this method could be effectively applied to analyze the fouling of such membranes. It is known that the water flux of membranes drastically decreases as a result of fouling by surfactants. Although the surfactants adsorbed on reverse osmosis membranes could not be detected by conventional methods such as SEM, EDX and FT-IR, their presence could be clarified by the profile measurements of the surface zeta-potential. The profiles of the membrane surface zeta-potentials changed to more positive values in the measured pH range as a result of fouling by cationic or amphoteric surfactants. This measuring method of surface zeta-potentials allowed us to analyze a very small amount of fouling of a thin film composite reverse osmosis membrane. This method could be used to analyze the fouled surface of the thin film composite reverse osmosis membrane which is used for production of ultrapure water and shows a remarkable decrease in flux. It also became clear that this method is easy and effective for the reverse osmosis membrane surface analysis of adsorbed materials such as surfactants. (author)

  4. The Isolation of DNA by Polycharged Magnetic Particles: An Analysis of the Interaction by Zeta Potential and Particle Size.

    Science.gov (United States)

    Haddad, Yazan; Xhaxhiu, Kledi; Kopel, Pavel; Hynek, David; Zitka, Ondrej; Adam, Vojtech

    2016-04-20

    Magnetic isolation of biological targets is in major demand in the biotechnology industry today. This study considers the interaction of four surface-modified magnetic micro- and nanoparticles with selected DNA fragments. Different surface modifications of nanomaghemite precursors were investigated: MAN37 (silica-coated), MAN127 (polyvinylpyrrolidone-coated), MAN158 (phosphate-coated), and MAN164 (tripolyphosphate-coated). All particles were positive polycharged agglomerated monodispersed systems. Mean particle sizes were 0.48, 2.97, 2.93, and 3.67 μm for MAN37, MAN127, MAN164, and MAN158, respectively. DNA fragments exhibited negative zeta potential of -0.22 mV under binding conditions (high ionic strength, low pH, and dehydration). A decrease in zeta potential of particles upon exposure to DNA was observed with exception of MAN158 particles. The measured particle size of MAN164 particles increased by nearly twofold upon exposure to DNA. Quantitative PCR isolation of DNA with a high retrieval rate was observed by magnetic particles MAN127 and MAN164. Interaction between polycharged magnetic particles and DNA is mediated by various binding mechanisms such as hydrophobic and electrostatic interactions. Future development of DNA isolation technology requires an understanding of the physical and biochemical conditions of this process.

  5. Oscillatory electroosmotic flow in a parallel-plate microchannel under asymmetric zeta potentials

    Science.gov (United States)

    Peralta, M.; Arcos, J.; Méndez, F.; Bautista, O.

    2017-06-01

    In this work, we conduct a theoretical analysis of the start-up of an oscillatory electroosmotic flow (EOF) in a parallel-plate microchannel under asymmetric zeta potentials. It is found that the transient evolution of the flow field is controlled by the parameters {R}ω , {R}\\zeta , and \\bar{κ }, which represent the dimensionless frequency, the ratio of the zeta potentials of the microchannel walls, and the electrokinetic parameter, which is defined as the ratio of the microchannel height to the Debye length. The analysis is performed for both low and high zeta potentials; in the former case, an analytical solution is derived, whereas in the latter, a numerical solution is obtained. These solutions provide the fundamental characteristics of the oscillatory EOFs for which, with suitable adjustment of the zeta potential and the dimensionless frequency, the velocity profiles of the fluid flow exhibit symmetric or asymmetric shapes.

  6. Zeta-potential and flotability of the scheelite mineral in different type of waters, Part 1: Zeta-potential

    Directory of Open Access Journals (Sweden)

    Milanović Dragan B.

    2009-01-01

    Full Text Available The aim of this work is the investigation of zeta-potential of the mineral scheelite from mine 'Rudnik', located in central Serbia. Electrophoresis measurements using zeta-meter were carried out on four different types of water, namely: tap water, distilled water, rain water and spring water. All types of water had different hardness and conductivity as well as natural pH values. It was found that the zeta-potential of mineral scheelite depends on the hardness and electro-conductivity of the chosen type of water as well as on Ca2+ content. The results obtained reveal the importance of proper choice of water as well as the type of reagents for flotation processes.

  7. Zeta-function approach to Casimir energy with singular potentials

    International Nuclear Information System (INIS)

    Khusnutdinov, Nail R.

    2006-01-01

    In the framework of zeta-function approach the Casimir energy for three simple model system: single delta potential, step function potential and three delta potentials are analyzed. It is shown that the energy contains contributions which are peculiar to the potentials. It is suggested to renormalize the energy using the condition that the energy of infinitely separated potentials is zero which corresponds to subtraction all terms of asymptotic expansion of zeta-function. The energy obtained in this way obeys all physically reasonable conditions. It is finite in the Dirichlet limit, and it may be attractive or repulsive depending on the strength of potential. The effective action is calculated, and it is shown that the surface contribution appears. The renormalization of the effective action is discussed

  8. Measuring the zeta potential. The relationships with sandstone fineness

    Directory of Open Access Journals (Sweden)

    de Luxán, M. P.

    1989-09-01

    Full Text Available The application of the zeta potential technique in the area of construction materials and Portland cement is quite recent. The initial research work involved the study of cement suspensions or suspensions of one of the components of cement, such as alite, tricalcium alumínate, in the presence of additives and, more specifically, superplasticizers. The studies of this sort were extended with the mixing of active additions into cement (fly ashes, etc.. The present study discusses the application of siliceous materials (sandstone as a basis of the research into the behaviour of sandstone mortars containing repair products.

    La aplicación de la técnica del potencial zeta en el campo de los materiales de construcción y del cemento portland es muy reciente. Las primeras investigaciones se refieren al estudio de suspensiones de cemento o de alguno de sus compuestos que lo forman como alita, aluminato tricálcico, en presencia de aditivos y, más concretamente, de superfluidificantes. Con la incorporación de adiciones activas al cemento (cenizas volantes,... se amplían los estudios de este tipo de cementos. En este trabajo se considera la aplicación a los materiales silíceos (arenisca como base para la investigación del comportamiento de los morteros de arenisca conteniendo productos de reparación.

  9. Synthesis, bioactivity and zeta potential investigations of chlorine and fluorine substituted hydroxyapatite.

    Science.gov (United States)

    Fahami, Abbas; Beall, Gary W; Betancourt, Tania

    2016-02-01

    Chlorine and fluorine substituted hydroxyapatites (HA-Cl-F) with different degrees of ion replacement were successfully prepared by the one step mechanochemical activation method. X-ray diffraction (XRD) and FT-IR spectra indicated that substitution of these anions in milled powders resulted in the formation of pure hydroxyapatite phase except for the small observed change in the lattice parameters and unit cell volumes of the resultant hydroxyapatite. Microscopic observations showed that the milled product had a cluster-like structure made up of polygonal and spherical particles with an average particle size of approximately ranged from 20±5 to 70±5nm. The zeta potential of milled samples was performed at three different pH (5, 7.4, and 9). The obtained zeta potential values were negative for all three pH values. Negative zeta potential was described to favor osseointegration, apatite nucleation, and bone regeneration. The bioactivity of samples was investigated on sintered pellets soaked in simulated body fluid (SBF) solution and apatite crystals formed on the surface of the pellets after being incubated for 14days. Zeta potential analysis and bioactivity experiment suggested that HA-Cl-F will lead to the formation of new apatite particles and therefore be a potential implant material. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Zeta potentials in the flotation of oxide and silicate minerals.

    Science.gov (United States)

    Fuerstenau, D W; Pradip

    2005-06-30

    Adsorption of collectors and modifying reagents in the flotation of oxide and silicate minerals is controlled by the electrical double layer at the mineral-water interface. In systems where the collector is physically adsorbed, flotation with anionic or cationic collectors depends on the mineral surface being charged oppositely. Adjusting the pH of the system can enhance or prevent the flotation of a mineral. Thus, the point of zero charge (PZC) of the mineral is the most important property of a mineral in such systems. The length of the hydrocarbon chain of the collector is important because of chain-chain association enhances the adsorption once the surfactant ions aggregate to form hemimicelles at the surface. Strongly chemisorbing collectors are able to induce flotation even when collector and the mineral surface are charged similarly, but raising the pH sufficiently above the PZC can repel chemisorbing collectors from the mineral surface. Zeta potentials can be used to delineate interfacial phenomena in these various systems.

  11. Electroosmotic flow of Phan-Thien-Tanner fluids at high zeta potentials: An exact analytical solution

    Science.gov (United States)

    Sarma, Rajkumar; Deka, Nabajit; Sarma, Kuldeep; Mondal, Pranab Kumar

    2018-06-01

    We present a mathematical model to study the electroosmotic flow of a viscoelastic fluid in a parallel plate microchannel with a high zeta potential, taking hydrodynamic slippage at the walls into account in the underlying analysis. We use the simplified Phan-Thien-Tanner (s-PTT) constitutive relationships to describe the rheological behavior of the viscoelastic fluid, while Navier's slip law is employed to model the interfacial hydrodynamic slip. Here, we derive analytical solutions for the potential distribution, flow velocity, and volumetric flow rate based on the complete Poisson-Boltzmann equation (without considering the frequently used Debye-Hückel linear approximation). For the underlying electrokinetic transport, this investigation primarily reveals the influence of fluid rheology, wall zeta potential as modulated by the interfacial electrochemistry and interfacial slip on the velocity distribution, volumetric flow rate, and fluid stress, as well as the apparent viscosity. We show that combined with the viscoelasticity of the fluid, a higher wall zeta potential and slip coefficient lead to a phenomenal enhancement in the volumetric flow rate. We believe that this analysis, besides providing a deep theoretical insight to interpret the transport process, will also serve as a fundamental design tool for microfluidic devices/systems under electrokinetic influence.

  12. Synthesis, bioactivity and zeta potential investigations of chlorine and fluorine substituted hydroxyapatite

    International Nuclear Information System (INIS)

    Fahami, Abbas; Beall, Gary W.; Betancourt, Tania

    2016-01-01

    Chlorine and fluorine substituted hydroxyapatites (HA-Cl–F) with different degrees of ion replacement were successfully prepared by the one step mechanochemical activation method. X-ray diffraction (XRD) and FT-IR spectra indicated that substitution of these anions in milled powders resulted in the formation of pure hydroxyapatite phase except for the small observed change in the lattice parameters and unit cell volumes of the resultant hydroxyapatite. Microscopic observations showed that the milled product had a cluster-like structure made up of polygonal and spherical particles with an average particle size of approximately ranged from 20 ± 5 to 70 ± 5 nm. The zeta potential of milled samples was performed at three different pH (5, 7.4, and 9). The obtained zeta potential values were negative for all three pH values. Negative zeta potential was described to favor osseointegration, apatite nucleation, and bone regeneration. The bioactivity of samples was investigated on sintered pellets soaked in simulated body fluid (SBF) solution and apatite crystals formed on the surface of the pellets after being incubated for 14 days. Zeta potential analysis and bioactivity experiment suggested that HA-Cl–F will lead to the formation of new apatite particles and therefore be a potential implant material. - Highlights: • Cl"− and F"− substituted hydroxyapatite was synthesized by mechanochemical process. • Structural features were influenced strongly by incorporation of different ions. • Microscopic observations showed a mean particle size of around 20 ± 5 to 70 ± 5 nm. • The bioactivity properties indicated that apatite was successfully formed.

  13. Synthesis, bioactivity and zeta potential investigations of chlorine and fluorine substituted hydroxyapatite

    Energy Technology Data Exchange (ETDEWEB)

    Fahami, Abbas, E-mail: fahami@txstate.edu [Materials Science, Engineering and Commercialization Program, Texas State University, San Marcos, TX 78666 (United States); Beall, Gary W. [Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX 78666 (United States); Physics Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Betancourt, Tania [Materials Science, Engineering and Commercialization Program, Texas State University, San Marcos, TX 78666 (United States); Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX 78666 (United States)

    2016-02-01

    Chlorine and fluorine substituted hydroxyapatites (HA-Cl–F) with different degrees of ion replacement were successfully prepared by the one step mechanochemical activation method. X-ray diffraction (XRD) and FT-IR spectra indicated that substitution of these anions in milled powders resulted in the formation of pure hydroxyapatite phase except for the small observed change in the lattice parameters and unit cell volumes of the resultant hydroxyapatite. Microscopic observations showed that the milled product had a cluster-like structure made up of polygonal and spherical particles with an average particle size of approximately ranged from 20 ± 5 to 70 ± 5 nm. The zeta potential of milled samples was performed at three different pH (5, 7.4, and 9). The obtained zeta potential values were negative for all three pH values. Negative zeta potential was described to favor osseointegration, apatite nucleation, and bone regeneration. The bioactivity of samples was investigated on sintered pellets soaked in simulated body fluid (SBF) solution and apatite crystals formed on the surface of the pellets after being incubated for 14 days. Zeta potential analysis and bioactivity experiment suggested that HA-Cl–F will lead to the formation of new apatite particles and therefore be a potential implant material. - Highlights: • Cl{sup −} and F{sup −} substituted hydroxyapatite was synthesized by mechanochemical process. • Structural features were influenced strongly by incorporation of different ions. • Microscopic observations showed a mean particle size of around 20 ± 5 to 70 ± 5 nm. • The bioactivity properties indicated that apatite was successfully formed.

  14. Influence of surface conductivity on the apparent zeta potential of calcite.

    Science.gov (United States)

    Li, Shuai; Leroy, Philippe; Heberling, Frank; Devau, Nicolas; Jougnot, Damien; Chiaberge, Christophe

    2016-04-15

    Zeta potential is a physicochemical parameter of particular importance in describing the surface electrical properties of charged porous media. However, the zeta potential of calcite is still poorly known because of the difficulty to interpret streaming potential experiments. The Helmholtz-Smoluchowski (HS) equation is widely used to estimate the apparent zeta potential from these experiments. However, this equation neglects the influence of surface conductivity on streaming potential. We present streaming potential and electrical conductivity measurements on a calcite powder in contact with an aqueous NaCl electrolyte. Our streaming potential model corrects the apparent zeta potential of calcite by accounting for the influence of surface conductivity and flow regime. We show that the HS equation seriously underestimates the zeta potential of calcite, particularly when the electrolyte is diluted (ionic strength ⩽ 0.01 M) because of calcite surface conductivity. The basic Stern model successfully predicted the corrected zeta potential by assuming that the zeta potential is located at the outer Helmholtz plane, i.e. without considering a stagnant diffuse layer at the calcite-water interface. The surface conductivity of calcite crystals was inferred from electrical conductivity measurements and computed using our basic Stern model. Surface conductivity was also successfully predicted by our surface complexation model. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Zeta potential of microfluidic substrates: 1. Theory, experimental techniques, and effects on separations.

    Science.gov (United States)

    Kirby, Brian J; Hasselbrink, Ernest F

    2004-01-01

    This paper summarizes theory, experimental techniques, and the reported data pertaining to the zeta potential of silica and silicon with attention to use as microfluidic substrate materials, particularly for microchip chemical separations. Dependence on cation concentration, buffer and cation type, pH, cation valency, and temperature are discussed. The Debye-Hückel limit, which is often correctly treated as a good approximation for describing the ion concentration in the double layer, can lead to serious errors if it is extended to predict the dependence of zeta potential on the counterion concentration. For indifferent univalent electrolytes (e.g., sodium and potassium), two simple scalings for the dependence of zeta potential on counterion concentration can be derived in high- and low-zeta limits of the nonlinear Poisson-Boltzman equation solution in the double layer. It is shown that for most situations relevant to microchip separations, the high-zeta limit is most applicable, leading to the conclusion that the zeta potential on silica substrates is approximately proportional to the logarithm of the molar counterion concentration. The zeta vs. pH dependence measurements from several experiments are compared by normalizing the zeta based on concentration.

  16. Surface Complexation Modeling of Calcite Zeta Potential Measurement in Mixed Brines for Carbonate Wettability Characterization

    Science.gov (United States)

    Song, J.; Zeng, Y.; Biswal, S. L.; Hirasaki, G. J.

    2017-12-01

    We presents zeta potential measurements and surface complexation modeling (SCM) of synthetic calcite in various conditions. The systematic zeta potential measurement and the proposed SCM provide insight into the role of four potential determining cations (Mg2+, SO42- , Ca2+ and CO32-) and CO2 partial pressure in calcite surface charge formation and facilitate the revealing of calcite wettability alteration induced by brines with designed ionic composition ("smart water"). Brines with varying potential determining ions (PDI) concentration in two different CO2 partial pressure (PCO2) are investigated in experiments. Then, a double layer SCM is developed to model the zeta potential measurements. Moreover, we propose a definition for contribution of charged surface species and quantitatively analyze the variation of charged species contribution when changing brine composition. After showing our model can accurately predict calcite zeta potential in brines containing mixed PDIs, we apply it to predict zeta potential in ultra-low and pressurized CO2 environments for potential applications in carbonate enhanced oil recovery including miscible CO2 flooding and CO2 sequestration in carbonate reservoirs. Model prediction reveals that pure calcite surface will be positively charged in all investigated brines in pressurized CO2 environment (>1atm). Moreover, the sensitivity of calcite zeta potential to CO2 partial pressure in the various brine is found to be in the sequence of Na2CO3 > Na2SO4 > NaCl > MgCl2 > CaCl2 (Ionic strength=0.1M).

  17. An induced current method for measuring zeta potential of electrolyte solution-air interface.

    Science.gov (United States)

    Song, Yongxin; Zhao, Kai; Wang, Junsheng; Wu, Xudong; Pan, Xinxiang; Sun, Yeqing; Li, Dongqing

    2014-02-15

    This paper reports a novel and very simple method for measuring the zeta potential of electrolyte solution-air interface. When a measuring electrode contacts the electrolyte solution-air interface, an electrical current will be generated due to the potential difference between the electrode-air surface and the electrolyte solution-air interface. The amplitude of the measured electric signal is linearly proportional to this potential difference; and depends only on the zeta potential at the electrolyte solution-air interface, regardless of the types and concentrations of the electrolyte. A correlation between the zeta potential and the measured voltage signal is obtained based on the experimental data. Using this equation, the zeta potential of any electrolyte solution-air interface can be evaluated quickly and easily by inserting an electrode through the electrolyte solution-air interface and measuring the electrical signal amplitude. This method was verified by comparing the obtained results of NaCl, MgCl2 and CaCl2 solutions of different pH values and concentrations with the zeta potential data reported in the published journal papers. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Effect of Zeta Potential on the Properties of Nano-Drug Delivery ...

    African Journals Online (AJOL)

    Zeta potential is a scientific term for electrokinetic potential in colloidal systems which has a major effect on the various properties of nano-drug delivery systems. Presently, colloidal nano-carriers are growing at a remarkable rate owing to their strong potential for overcoming old challenges such as poor drug solubility and ...

  19. Application of the zeta potential for stationary phase characterization in ion chromatography.

    Science.gov (United States)

    Buszewski, Bogusław; Jaćkowska, Magdalena; Bocian, Szymon; Dziubakiewicz, Ewelina

    2013-01-01

    Two series of homemade stationary bonded phases for ion chromatography were investigated according to their zeta potential. One set of dendrimer anion exchanger was synthesized on the polymer support whereas the second material was prepared on the silica gel. The zeta potential data in water environment as well as buffered water solution were obtained. The influence of the length of anion-exchanger chains, the type of the support of the modified surface, and charge distribution on these data was investigated. Additionally, the zeta potential was correlated with retention factor of inorganic ions to describe their influence on the retention mechanism in ion chromatography. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Analyte preconcentration in nanofluidic channels with nonuniform zeta potential

    Science.gov (United States)

    Eden, A.; McCallum, C.; Storey, B. D.; Pennathur, S.; Meinhart, C. D.

    2017-12-01

    It is well known that charged analytes in the presence of nonuniform electric fields concentrate at locations where the relevant driving forces balance, and a wide range of ionic stacking and focusing methods are commonly employed to leverage these physical mechanisms in order to improve signal levels in biosensing applications. In particular, nanofluidic channels with spatially varying conductivity distributions have been shown to provide increased preconcentration of charged analytes due to the existence of a finite electric double layer (EDL), in which electrostatic attraction and repulsion from charged surfaces produce nonuniform transverse ion distributions. In this work, we use numerical simulations to show that one can achieve greater levels of sample accumulation by using field-effect control via wall-embedded electrodes to tailor the surface potential heterogeneity in a nanochannel with overlapped EDLs. In addition to previously demonstrated stacking and focusing mechanisms, we find that the coupling between two-dimensional ion distributions and the axial electric field under overlapped EDL conditions can generate an ion concentration polarization interface in the middle of the channel. Under an applied electric field, this interface can be used to concentrate sample ions between two stationary regions of different surface potential and charge density. Our numerical model uses the Poisson-Nernst-Planck system of equations coupled with the Stokes equation to demonstrate the phenomenon, and we discuss in detail the driving forces behind the predicted sample enhancement. The numerical velocity and salt concentration profiles exhibit good agreement with analytical results from a simplified one-dimensional area-averaged model for several limiting cases, and we show predicted amplification ratios of up to 105.

  1. Effect of Zeta Potential on the Properties of Nano-Drug Delivery ...

    African Journals Online (AJOL)

    The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes ...

  2. Zeta potential of Polish copper-bearing shale in the absence and presence of flotation frothers

    Directory of Open Access Journals (Sweden)

    Mengsu Peng

    2014-09-01

    Full Text Available In this paper, zeta potential as a function of pH of copper-bearing shale, which is mined in Poland by KGHM, was investigated. The measurements were conducted in water and aqueous solutions of selected flotation frothers. It was established that for investigated copper-bearing shale, after dispersion in water, the isoelectric point (IEP occurs at pH=3.5. Addition of frothers decreased the IEP on the pH scale and the IEP for butanol was 1.93, for MIBC 2.90 and for eicosaethylene glycol hexadecyl ether (C16E20 2.76. In the case of introducing frothers changed, the zeta potential becomes less negative. An empirical equation, having two adjustable parameters, was used in the paper to approximate the course of the zeta potential-pH curve. The equation showed a very good approximation of the zeta potential of the investigated shale either in water or frother aqueous solutions.

  3. Chitosan-magnesium aluminum silicate composite dispersions: characterization of rheology, flocculate size and zeta potential.

    Science.gov (United States)

    Khunawattanakul, Wanwisa; Puttipipatkhachorn, Satit; Rades, Thomas; Pongjanyakul, Thaned

    2008-03-03

    Composite dispersions of chitosan (CS), a positively charged polymer, and magnesium aluminum silicate (MAS), a negatively charged clay, were prepared and rheology, flocculate size and zeta potential of the CS-MAS dispersions were investigated. High and low molecular weights of CS (HCS and LCS, respectively) were used in this study. Moreover, the effects of heat treatment at 60 degrees C on the characteristics of the CS-MAS dispersions and the zeta potential of MAS upon addition of CS at different pHs were examined. Incorporation of MAS into CS dispersions caused an increase in viscosity and a shift of CS flow type from Newtonian to pseudoplastic flow with thixotropic properties. Heat treatment brought about a significant decrease in viscosity and hysteresis area of the composite dispersions. Microscopic studies showed that flocculation of MAS occurred after mixing with CS. The size and polydispersity index of the HCS-MAS flocculate were greater than those of the LCS-MAS flocculate. However, a narrower size distribution and the smaller size of the HCS-MAS flocculate were found after heating at 60 degrees C. Zeta potentials of the CS-MAS flocculates were positive and slightly increased with increasing MAS content. In the zeta potential studies, the negative charge of the MAS could be neutralized by the addition of CS. Increasing the pH and molecular weight of CS resulted in higher CS concentrations required to neutralize the charge of MAS. These findings suggest that the electrostatic interaction between CS and MAS caused a change in flow behavior and flocculation of the composite dispersions, depending on the molecular weight of CS. Heat treatment affected the rheological properties and the flocculate size of the composite dispersions. Moreover, pH of medium and molecular weight of CS influence the zeta potential of MAS.

  4. Influence of synthesis parameters on iron nanoparticle size and zeta potential

    Science.gov (United States)

    Goldstein, Nikki; Greenlee, Lauren F.

    2012-03-01

    Zero valent iron nanoparticles are of increasing interest in clean water treatment applications due to their reactivity toward organic contaminants and their potential to degrade a variety of compounds. This study focuses on the effect of organophosphate stabilizers on nanoparticle characteristics, including particle size distribution and zeta potential, when the stabilizer is present during nanoparticle synthesis. Particle size distributions from DLS were obtained as a function of stabilizer type and iron precursor (FeSO4·7H2O or FeCl3), and nanoparticles from 2 to 200 nm were produced. Three different organophosphate stabilizer compounds were compared in their ability to control nanoparticle size, and the size distributions obtained for particle volume demonstrated differences caused by the three stabilizers. A range of stabilizer-to-iron (0.05-0.9) and borohydride-to-iron (0.5-8) molar ratios were tested to determine the effect of concentration on nanoparticle size distribution and zeta potential. The combination of ferrous sulfate and ATMP or DTPMP phosphonate stabilizer produced stabilized nanoparticle suspensions, and the stabilizers tested resulted in varying particle size distributions. In general, higher stabilizer concentrations resulted in smaller nanoparticles, and excess borohydride did not decrease nanoparticle size. Zeta potential measurements were largely consistent with particle size distribution data and indicated the stability of the suspensions. Probe sonication, as a nanoparticle resuspension method, was minimally successful in several different organic solvents.

  5. Influence of synthesis parameters on iron nanoparticle size and zeta potential

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Nikki; Greenlee, Lauren F., E-mail: lauren.greenlee@nist.gov [National Institute of Standards and Technology, Materials Reliability Division (United States)

    2012-03-15

    Zero valent iron nanoparticles are of increasing interest in clean water treatment applications due to their reactivity toward organic contaminants and their potential to degrade a variety of compounds. This study focuses on the effect of organophosphate stabilizers on nanoparticle characteristics, including particle size distribution and zeta potential, when the stabilizer is present during nanoparticle synthesis. Particle size distributions from DLS were obtained as a function of stabilizer type and iron precursor (FeSO{sub 4}{center_dot}7H{sub 2}O or FeCl{sub 3}), and nanoparticles from 2 to 200 nm were produced. Three different organophosphate stabilizer compounds were compared in their ability to control nanoparticle size, and the size distributions obtained for particle volume demonstrated differences caused by the three stabilizers. A range of stabilizer-to-iron (0.05-0.9) and borohydride-to-iron (0.5-8) molar ratios were tested to determine the effect of concentration on nanoparticle size distribution and zeta potential. The combination of ferrous sulfate and ATMP or DTPMP phosphonate stabilizer produced stabilized nanoparticle suspensions, and the stabilizers tested resulted in varying particle size distributions. In general, higher stabilizer concentrations resulted in smaller nanoparticles, and excess borohydride did not decrease nanoparticle size. Zeta potential measurements were largely consistent with particle size distribution data and indicated the stability of the suspensions. Probe sonication, as a nanoparticle resuspension method, was minimally successful in several different organic solvents.

  6. Influence of synthesis parameters on iron nanoparticle size and zeta potential

    International Nuclear Information System (INIS)

    Goldstein, Nikki; Greenlee, Lauren F.

    2012-01-01

    Zero valent iron nanoparticles are of increasing interest in clean water treatment applications due to their reactivity toward organic contaminants and their potential to degrade a variety of compounds. This study focuses on the effect of organophosphate stabilizers on nanoparticle characteristics, including particle size distribution and zeta potential, when the stabilizer is present during nanoparticle synthesis. Particle size distributions from DLS were obtained as a function of stabilizer type and iron precursor (FeSO 4 ·7H 2 O or FeCl 3 ), and nanoparticles from 2 to 200 nm were produced. Three different organophosphate stabilizer compounds were compared in their ability to control nanoparticle size, and the size distributions obtained for particle volume demonstrated differences caused by the three stabilizers. A range of stabilizer-to-iron (0.05–0.9) and borohydride-to-iron (0.5–8) molar ratios were tested to determine the effect of concentration on nanoparticle size distribution and zeta potential. The combination of ferrous sulfate and ATMP or DTPMP phosphonate stabilizer produced stabilized nanoparticle suspensions, and the stabilizers tested resulted in varying particle size distributions. In general, higher stabilizer concentrations resulted in smaller nanoparticles, and excess borohydride did not decrease nanoparticle size. Zeta potential measurements were largely consistent with particle size distribution data and indicated the stability of the suspensions. Probe sonication, as a nanoparticle resuspension method, was minimally successful in several different organic solvents.

  7. Effects on functional groups and zeta potential of SAP1pulsed electric field technology.

    Science.gov (United States)

    Liang, Rong; Li, Xuenan; Lin, Songyi; Wang, Jia

    2017-01-01

    SAP 1 pulsed electric field (PEF) technology. The effects of electric field intensity and pulse frequency on SAP 1 electric field intensity 15 kV cm -1 , pulse frequency 1600 Hz and flow velocity 2.93 mL min -1 ). Furthermore, the PEF-treated SAP 1 < MW < 3kDa under optimal conditions lacked the characteristic absorbance of N-H, C = C and the amide band and the zeta potential was reduced to -18.0 mV. Overall, the results of the present study suggest that the improvement of antioxidant activity of SAP 1 < MW < 3kDa is a result of the contribution of the functional groups and the change in zeta potential when treated with PEF. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  8. Entrapment of ovalbumin into liposomes--factors affecting entrapment efficiency, liposome size, and zeta potential.

    Science.gov (United States)

    Brgles, Marija; Jurasin, Darija; Sikirić, Maja Dutour; Frkanec, Ruza; Tomasić, Jelka

    2008-01-01

    Various amounts of Ovalbumin (OVA) were encapsulated into positively and negatively charged multilamellar liposomes, with the aim to investigate the entrapment efficiency in different buffers and to study their effects on the liposome size and zeta potential. Results showed that the entrapment efficiency of OVA in anionic liposomes was the same in 10 mM Phosphate Buffer (PB) as in Phosphate-Buffered Saline (PBS; PB + 0.15 M NaCl). Also, liposome size was approximately 1200 nm for all anionic liposomes incorporating OVA. The entrapment efficiency of OVA in cationic liposomes was highly dependent on ionic strength. The size of cationic liposomes was approximately 1200 nm in PBS, regardless of protein content, but increased with the amount of the incorporated protein in PB. Aggregation of cationic liposomes in PB was observed when the mass of the protein was 2.5 mg or greater. The zeta potential of anionic liposomes was negative and of cationic liposomes positive in the whole range of protein mass tested. These results show how different compositions of lipid and aqueous phases can be used to vary the entrapment efficiency, liposome size, and zeta potential--the factors that are of great importance for the use of liposomes as drug carriers.

  9. A Comparison of Streaming and Microelectrophoresis Methods for Obtaining the zeta Potential of Granular Porous Media Surfaces.

    Science.gov (United States)

    Johnson

    1999-01-01

    The electrokinetic behavior of granular quartz sand in aqueous solution is investigated by both microelectrophoresis and streaming potential methods. zeta potentials of surfaces composed of granular quartz obtained via streaming potential methods are compared to electrophoretic mobility zeta potential values of colloid-sized quartz fragments. The zeta values generated by these alternate methods are in close agreement over a wide pH range and electrolyte concentrations spanning several orders of magnitude. Streaming measurements performed on chemically heterogeneous mixtures of physically homogeneous sand are shown to obey a simple mixing model based on the surface area-weighted average of the streaming potentials associated with the individual end members. These experimental results support the applicability of the streaming potential method as a means of determining the zeta potential of granular porous media surfaces. Copyright 1999 Academic Press.

  10. Improving the Efficiency of a Coagulation-Flocculation Wastewater Treatment of the Semiconductor Industry through Zeta Potential Measurements

    OpenAIRE

    López-Maldonado, Eduardo Alberto; Oropeza-Guzmán, Mercedes Teresita; Ochoa-Terán, Adrián

    2014-01-01

    Efficiency of coagulation-flocculation process used for semiconductor wastewater treatment was improved by selecting suitable conditions (pH, polyelectrolyte type, and concentration) through zeta potential measurements. Under this scenario the zeta potential, ζ, is the right parameter that allows studying and predicting the interactions at the molecular level between the contaminants in the wastewater and polyelectrolytes used for coagulation-flocculation. Additionally, this parameter is a k...

  11. Effective flocculation of Chlorella vulgaris using chitosan with zeta potential measurement

    Science.gov (United States)

    Low, Y. J.; Lau, S. W.

    2017-06-01

    Microalgae are considered as one promising source of third-generation biofuels due to their fast growth rates, potentially higher yield rates and wide ranges of growth conditions. However, the extremely low biomass concentration in microalgae cultures presents a great challenge to the harvesting of microalgae because a large volume of water needs to be removed to obtain dry microalgal cells for the subsequent oil extraction process. In this study, the fresh water microalgae Chlorella vulgaris (C. vulgaris) was effectively harvested using both low molecular weight (MW) and high MW chitosan flocculants. The flocculation efficiency was evaluated by physical appearance, supernatant absorbance, zeta potential and solids content after centrifugal dewatering. High flocculation efficiency of 98.0-99.0% was achieved at the optimal dosage of 30-40 mg/g with formation of large microalgae flocs. This study suggests that the polymer bridging mechanism was governing the flocculation behaviour of C. vulgaris using high MW chitosan. Besides, charge patch neutralisation mechanism prevailed at low MW chitosan where lower dosage was sufficient to reach near-zero zeta potential compared with the high MW chitosan. The amount of chitosan polymer present in the culture may also affect the mechanism of flocculation.

  12. Zeta potential control in decontamination with inorganic membranes and inorganic adsorbents

    Energy Technology Data Exchange (ETDEWEB)

    Andalaft, E; Vega, R; Correa, M; Araya, R; Loyola, P [Comision Chilena de Energia Nuclear, Santiago (Chile)

    1997-02-01

    The application of some advanced separation processes such as microfiltration and ultrafiltration, electroosmosis and electrodialysis for treating nuclear waste from different aqueous streams is under examination at the Chilean Commission for Nuclear Energy. The application of these techniques can be extended to regular industrial wastes when economically advisable. This report deals mainly with electrodialysis, electroosmosis and adsorption with inorganic materials. Special attention is paid to zeta potential control as a driving factor to electroosmosis. For radioactive contaminants that are present in the form of cations, anions, non-ionic solutions, colloids and suspended matter, appropriate combination of the processes may considerably increase the efficiency of processes used. As an example, colloids and suspended particles may be retained in porous ceramic membranes by nanofiltration, ultrafiltration or microfiltration depending on the particle size of the particles. The control of zeta potential by acting in the solid phase or else on the liquid phase has been studied; a mathematical model to predict electrodialysis data has been developed, and finally, the use of a home-made inorganic adsorbent illustrated. The effect of gamma irradiation on the membranes has also been studied. Properties such as salt retention, water flux and pore size diameter determined on both organic and inorganic membranes before and after irradiation indicate deterioration of the organic membrane. (author). 13 refs, 15 figs, 2 tabs.

  13. Zeta potential control in decontamination with inorganic membranes and inorganic adsorbents

    International Nuclear Information System (INIS)

    Andalaft, E.; Vega, R.; Correa, M.; Araya, R.; Loyola, P.

    1997-01-01

    The application of some advanced separation processes such as microfiltration and ultrafiltration, electroosmosis and electrodialysis for treating nuclear waste from different aqueous streams is under examination at the Chilean Commission for Nuclear Energy. The application of these techniques can be extended to regular industrial wastes when economically advisable. This report deals mainly with electrodialysis, electroosmosis and adsorption with inorganic materials. Special attention is paid to zeta potential control as a driving factor to electroosmosis. For radioactive contaminants that are present in the form of cations, anions, non-ionic solutions, colloids and suspended matter, appropriate combination of the processes may considerably increase the efficiency of processes used. As an example, colloids and suspended particles may be retained in porous ceramic membranes by nanofiltration, ultrafiltration or microfiltration depending on the particle size of the particles. The control of zeta potential by acting in the solid phase or else on the liquid phase has been studied; a mathematical model to predict electrodialysis data has been developed, and finally, the use of a home-made inorganic adsorbent illustrated. The effect of gamma irradiation on the membranes has also been studied. Properties such as salt retention, water flux and pore size diameter determined on both organic and inorganic membranes before and after irradiation indicate deterioration of the organic membrane. (author). 13 refs, 15 figs, 2 tabs

  14. Stability of fenbendazole suspensions for veterinary use. Correlation between zeta potential and sedimentation.

    Science.gov (United States)

    Arias, José L; López-Viota, Margarita; Clares, Beatriz; Ruiz, Ma Adolfina

    2008-08-07

    In this paper we have carried out a detailed investigation of the stability and redispersibility characteristics of fenbendazole aqueous suspensions, through a thermodynamic and electrokinetic characterization, considering the effect of both pH and ionic strength. The hydrophobic character of the drug, and the surface charge and electrical double-layer thickness play an essential role in the stability of the system, hence the need for a full characterization of fenbendazole. It was found that the drug suspensions displays "delayed" or "hindered" sedimentation, determined by their hydrophobic character and their low zeta potential (indicating a small electrokinetic charge on the particles). The electrostatic repulsion between the particles is responsible for the low sedimentation volume and poor redispersibility of the drug. However, only low concentrations of AlCl(3) induced a significant effect on both the zeta potential and stability of the drug, leading to a "free-layered" sedimentation and a very easy redispersion which could be of great interest in the design of an oral pharmaceutical dosage form for veterinary.

  15. Asymptotic analysis on a pseudo-Hermitian Riemann-zeta Hamiltonian

    Science.gov (United States)

    Bender, Carl M.; Brody, Dorje C.

    2018-04-01

    The differential-equation eigenvalue problem associated with a recently-introduced Hamiltonian, whose eigenvalues correspond to the zeros of the Riemann zeta function, is analyzed using Fourier and WKB analysis. The Fourier analysis leads to a challenging open problem concerning the formulation of the eigenvalue problem in the momentum space. The WKB analysis gives the exact asymptotic behavior of the eigenfunction.

  16. Zeta potential and Raman studies of PVP capped Bi2S3 nanoparticles synthesized by polyol method

    Science.gov (United States)

    Tarachand, Sathe, Vasant G.; Okram, Gunadhor S.

    2018-05-01

    Here we report the synthesis and characterisation of polyvinylpyrrolidone (PVP) capped Bi2S3 nanoparticles via one step catalyst-free polyol method. Raman spectroscopy, dynamic light scattering and zeta potential analysis were performed on it. Rietveld refinement of powder XRD of PVP capped samples confirmed the formation of single phase orthorhombic Bi2S3 for all PVP capped samples. The presence of eight obvious Raman modes further confirmed the formation of stoichiometric Bi2S3. Dynamic light scattering (DLS) studies show a clear increase in hydrodynamic diameter for samples made with increasing PVP concentration. Particle size obtained from DLS and XRD (using Scherrer's formula) combine with change in full width half maxima of Raman modes collectively suggest overall improvement in crystallinity and quality of product on introducing PVP. In zeta potential (ζ) measurement, steric hindrance of carbon chains plays very crucial role and a systematic reduction of ζ value is observed for samples made with decreasing PVP concentration. An isoelectric point is obtained for sample made with low PVP (1g). Present results are likely to open a window for its medical and catalytic applications.

  17. ZETA POTENTIAL AND COLOR INVESTIGATIONS OF VEGETABLE OIL BASED EMULSIONS AS ECO-FRIENDLY LUBRICANTS

    Directory of Open Access Journals (Sweden)

    ROMICĂ CREŢU

    2017-06-01

    Full Text Available In the past 10 years, the need for biodegradable lubricants has been more and more emphasized. The use of vegetable oils as lubricants offers several advantages. The vegetable oils are biodegradable; thus, the environmental pollution is minimal either during or after their use. The aim of this paper is to presents a preliminary study concerning the influence of some preparation conditions on the stability of vegetable oil-in-water (O/W emulsions as eco-friendly lubricants stabilized by nonionic surfactant. In this context, vegetable oil-in-water emulsions characteristics where assessed using microscopically observation and zeta potential. In addition, the color of these emulsions can be evaluated. It can be observed that the emulsions tend to stabilize in time.

  18. Cellular internalization of polycation-coated microparticles and its dependence on their zeta potential

    Science.gov (United States)

    Kato, Noritaka; Kondo, Ryosuke

    2018-03-01

    By applying microparticles to HeLa cells, the number of particles adhered on the cell and that of the ones internalized in the cells were evaluated. Three-dimensional tomographic images of the cells with the particles were obtained by multiphoton excitation laser scanning microscopy, and the adhered and internalized particles were counted separately. When the surface charge of the particles was reversed from negative to positive by coating the particles with polycations, both numbers significantly increased owing to the electrostatic attraction between the cells and the polycation-coated particles. Four different positively charged particles were prepared using four different polycations, and the numbers of adhered and internalized particles were compared. Our results suggest that these numbers depended on the zeta potential rather than the molecular structure of the polycation.

  19. Molecular cloning and expression analysis of a zeta-class ...

    African Journals Online (AJOL)

    Jane

    2011-07-27

    Jul 27, 2011 ... sugar-signalling pathway (Chi et al., 2010). All the earlier mentioned ... real-time qPCR analysis was the ABI PRISM7500 real-time PCR system. ... Construction of prokaryotic expression vector of Sc-GST gene. pET29a (+) ...

  20. Hydrodynamic dispersion in a combined magnetohydrodynamic- electroosmotic-driven flow through a microchannel with slowly varying wall zeta potentials

    Science.gov (United States)

    Vargas, C.; Arcos, J.; Bautista, O.; Méndez, F.

    2017-09-01

    The effective dispersion coefficient of a neutral solute in the combined electroosmotic (EO) and magnetohydrodynamic (MHD)-driven flow of a Newtonian fluid through a parallel flat plate microchannel is studied. The walls of the microchannel are assumed to have modulated and low zeta potentials that vary slowly in the axial direction in a sinusoidal manner. The flow field required to obtain the dispersion coefficient is solved using the lubrication approximation theory. The solution of the electrical potential is based on the Debye-Hückel approximation for a symmetric (Z :Z ) electrolyte solution. The EO and MHD effects, together with the variations in the zeta potentials of the walls, are observed to notably modify the axial distribution of the effective dispersion coefficient. The problem is formulated for two cases of the zeta potential function. Note that the dispersion coefficient primarily depends on the Hartmann number, on the ratio of the half height of the microchannel to the Debye length, and on the assumed variation in the zeta potentials of the walls.

  1. Effects of image charges, interfacial charge discreteness, and surface roughness on the zeta potential of spherical electric double layers.

    Science.gov (United States)

    Gan, Zecheng; Xing, Xiangjun; Xu, Zhenli

    2012-07-21

    We investigate the effects of image charges, interfacial charge discreteness, and surface roughness on spherical electric double layer structures in electrolyte solutions with divalent counterions in the setting of the primitive model. By using Monte Carlo simulations and the image charge method, the zeta potential profile and the integrated charge distribution function are computed for varying surface charge strengths and salt concentrations. Systematic comparisons were carried out between three distinct models for interfacial charges: (1) SURF1 with uniform surface charges, (2) SURF2 with discrete point charges on the interface, and (3) SURF3 with discrete interfacial charges and finite excluded volume. By comparing the integrated charge distribution function and the zeta potential profile, we argue that the potential at the distance of one ion diameter from the macroion surface is a suitable location to define the zeta potential. In SURF2 model, we find that image charge effects strongly enhance charge inversion for monovalent interfacial charges, and strongly suppress charge inversion for multivalent interfacial charges. For SURF3, the image charge effect becomes much smaller. Finally, with image charges in action, we find that excluded volumes (in SURF3) suppress charge inversion for monovalent interfacial charges and enhance charge inversion for multivalent interfacial charges. Overall, our results demonstrate that all these aspects, i.e., image charges, interfacial charge discreteness, their excluding volumes, have significant impacts on zeta potentials of electric double layers.

  2. Surface and zeta-potentials of silver halide single crystals: pH-dependence in comparison to particle systems

    International Nuclear Information System (INIS)

    Selmani, Atiða; Kallay, Nikola; Preočanin, Tajana; Lützenkirchen, Johannes

    2014-01-01

    We have carried out surface and zeta-potential measurements on AgCl and AgBr single crystals. As for particle systems we find that, surprisingly and previously unnoted, the zeta-potential exhibits pH-dependence, while the surface potential does not. A possible interpretation of these observations is the involvement of water ions in the interfacial equilibria and in particular, stronger affinity of the hydroxide ion compared to the proton. The pH-dependence of the zeta-potential can be suppressed at sufficiently high silver concentrations, which agrees with previous measurements in particle systems where no pH-dependence was found at high halide ion concentrations. The results suggest a subtle interplay between the surface potential determining the halide and silver ion concentrations, and the water ions. Whenever the charge due to the halide and silver ions is sufficiently high, the influence of the proton/hydroxide ion on the zeta-potential vanishes. This might be related to the water structuring at the relevant interfaces which should be strongly affected by the surface potential. Another interesting observation is accentuation of the assumed water ion effect on the zeta-potential at the flat single crystal surfaces compared to the corresponding silver halide colloids. Previous generic MD simulations have indeed predicted that hydroxide ion adsorption is accentuated on flat/rigid surfaces. A thermodynamic model for AgI single crystals was developed to describe the combined effects of iodide, silver and water ions, based on two independently previously published models for AgI (that only consider constituent and background electrolyte ions) and inert surfaces (that only consider water and background electrolyte ions). The combined model correctly predicts all the experimentally observed trends. (paper)

  3. Estimation of Nanodiamond Surface Charge Density from Zeta Potential and Molecular Dynamics Simulations.

    Science.gov (United States)

    Ge, Zhenpeng; Wang, Yi

    2017-04-20

    Molecular dynamics simulations of nanoparticles (NPs) are increasingly used to study their interactions with various biological macromolecules. Such simulations generally require detailed knowledge of the surface composition of the NP under investigation. Even for some well-characterized nanoparticles, however, this knowledge is not always available. An example is nanodiamond, a nanoscale diamond particle with surface dominated by oxygen-containing functional groups. In this work, we explore using the harmonic restraint method developed by Venable et al., to estimate the surface charge density (σ) of nanodiamonds. Based on the Gouy-Chapman theory, we convert the experimentally determined zeta potential of a nanodiamond to an effective charge density (σ eff ), and then use the latter to estimate σ via molecular dynamics simulations. Through scanning a series of nanodiamond models, we show that the above method provides a straightforward protocol to determine the surface charge density of relatively large (> ∼100 nm) NPs. Overall, our results suggest that despite certain limitation, the above protocol can be readily employed to guide the model construction for MD simulations, which is particularly useful when only limited experimental information on the NP surface composition is available to a modeler.

  4. Design and assembly of ternary Pt/Re/SnO2 NPs by controlling the zeta potential of individual Pt, Re, and SnO2 NPs

    Science.gov (United States)

    Drzymała, Elżbieta; Gruzeł, Grzegorz; Pajor-Świerzy, Anna; Depciuch, Joanna; Socha, Robert; Kowal, Andrzej; Warszyński, Piotr; Parlinska-Wojtan, Magdalena

    2018-05-01

    In this study Pt, Re, and SnO2 nanoparticles (NPs) were combined in a controlled manner into binary and ternary combinations for a possible application for ethanol oxidation. For this purpose, zeta potentials as a function of the pH of the individual NPs solutions were measured. In order to successfully combine the NPs into Pt/SnO2 and Re/SnO2 NPs, the solutions were mixed together at a pH guaranteeing opposite zeta potentials of the metal and oxide NPs. The individually synthesized NPs and their binary/ternary combinations were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning transmission electron microscopy (STEM) combined with energy dispersive X-ray spectroscopy (EDS) analysis. FTIR and XPS spectroscopy showed that the individually synthesized Pt and Re NPs are metallic and the Sn component was oxidized to SnO2. STEM showed that all NPs are well crystallized and the sizes of the Pt, Re, and SnO2 NPs were 2.2, 1.0, and 3.4 nm, respectively. Moreover, EDS analysis confirmed the successful formation of binary Pt/SnO2 and Re/SnO2 NP, as well as ternary Pt/Re/SnO2 NP combinations. This study shows that by controlling the zeta potential of individual metal and oxide NPs, it is possible to assemble them into binary and ternary combinations. [Figure not available: see fulltext.

  5. Biosynthesis and characterization of cadmium sulfide nanoparticles – An emphasis of zeta potential behavior due to capping

    International Nuclear Information System (INIS)

    Sankhla, Aryan; Sharma, Rajeshwar; Yadav, Raghvendra Singh; Kashyap, Diwakar; Kothari, S.L.; Kachhwaha, S.

    2016-01-01

    Biological approaches have been amongst the most promising protocols for synthesis of nanomaterials. In this study, Cadmium sulfide nanoparticles (CdS NPs) were synthesized by incubating their precursor salts with Escherichia coli and zeta potential (ζ-potential) measurement with varying pH was carried out to evaluate stability of the colloidal dispersion. Formation of CdS NPs was studied in synchrony with microbial growth. TEM analysis confirmed the uniform distribution of NPs. Average size (5 ± 0.4 nm) and electron diffraction pattern revealed polycrystalline cubic crystal phase of these nanoparticles. X-ray diffractogram ascertained the formation of CdS nanoparticles with phase formation and particle size distribution in accordance with the particle size obtained from TEM. Absorption edge of biosynthesized CdS NPs showed a blue shift at ∼400 nm in comparison to their bulk counterpart. A hump at 279 nm indicated presence of biomolecules in the solution in addition to the particles. FT-IR spectrum of capped CdS NPs showed peaks of protein. This confirms adsorption of protein molecules on nanoparticle surface. They act as a capping agent hence responsible for the stability of NPs. The enhanced stability of the particles was confirmed by Zeta potential analysis. The presence of charge on the surface of capped CdS NPs gave a detail understanding of dispersion mechanism and colloidal stability at the NP interface. This stability study of biosynthesized semiconductor nanoparticles utilizing microbial cells had not been done in the past by any research group providing an impetus for the same. Surface area of capped CdS NPs and bare CdS NPs were found to be 298 ± 2.65 m 2 /g and 117 ± 2.41 m 2 /g respectively. A possible mechanism is also proposed for the biosynthesis of CdS NPs. - Highlights: • Synthesis of CdS NPs utilizing reproducible molecular machinery viz. Escherichia coli biomass. • Uniform and Polydispersed NPs with high surface area and

  6. Biosynthesis and characterization of cadmium sulfide nanoparticles – An emphasis of zeta potential behavior due to capping

    Energy Technology Data Exchange (ETDEWEB)

    Sankhla, Aryan, E-mail: aaryansankhla@gmail.com [Centre for Converging Technologies, University of Rajasthan, Jaipur, 302015 (India); Sharma, Rajeshwar; Yadav, Raghvendra Singh [Centre for Converging Technologies, University of Rajasthan, Jaipur, 302015 (India); Kashyap, Diwakar [Department of Biological Chemistry, Ariel University, Ariel, 40700 (Israel); Kothari, S.L. [Institute of Biotechnology, Amity University, Jaipur, 303002 (India); Kachhwaha, S. [Department of Botany, University of Rajasthan, Jaipur, 302004 (India)

    2016-02-15

    Biological approaches have been amongst the most promising protocols for synthesis of nanomaterials. In this study, Cadmium sulfide nanoparticles (CdS NPs) were synthesized by incubating their precursor salts with Escherichia coli and zeta potential (ζ-potential) measurement with varying pH was carried out to evaluate stability of the colloidal dispersion. Formation of CdS NPs was studied in synchrony with microbial growth. TEM analysis confirmed the uniform distribution of NPs. Average size (5 ± 0.4 nm) and electron diffraction pattern revealed polycrystalline cubic crystal phase of these nanoparticles. X-ray diffractogram ascertained the formation of CdS nanoparticles with phase formation and particle size distribution in accordance with the particle size obtained from TEM. Absorption edge of biosynthesized CdS NPs showed a blue shift at ∼400 nm in comparison to their bulk counterpart. A hump at 279 nm indicated presence of biomolecules in the solution in addition to the particles. FT-IR spectrum of capped CdS NPs showed peaks of protein. This confirms adsorption of protein molecules on nanoparticle surface. They act as a capping agent hence responsible for the stability of NPs. The enhanced stability of the particles was confirmed by Zeta potential analysis. The presence of charge on the surface of capped CdS NPs gave a detail understanding of dispersion mechanism and colloidal stability at the NP interface. This stability study of biosynthesized semiconductor nanoparticles utilizing microbial cells had not been done in the past by any research group providing an impetus for the same. Surface area of capped CdS NPs and bare CdS NPs were found to be 298 ± 2.65 m{sup 2}/g and 117 ± 2.41 m{sup 2}/g respectively. A possible mechanism is also proposed for the biosynthesis of CdS NPs. - Highlights: • Synthesis of CdS NPs utilizing reproducible molecular machinery viz. Escherichia coli biomass. • Uniform and Polydispersed NPs with high surface area

  7. Zeta potentials of the rare earth element fluorcarbonate minerals focusing on bastnäsite and parisite.

    Science.gov (United States)

    Owens, C L; Nash, G R; Hadler, K; Fitzpatrick, R S; Anderson, C G; Wall, F

    2018-06-01

    Rare earth elements (REE) are critical to a wide range of technologies ranging from mobile phones to wind turbines. Processing and extraction of REE minerals from ore bodies is, however, both challenging and relatively poorly understood, as the majority of deposits contain only limited enrichment of REEs. An improved understanding of the surface properties of the minerals is important in informing and optimising their processing, in particular for separation by froth flotation. The measurement of zeta potential can be used to extract information regarding the electrical double layer, and hence surface properties of these minerals. There are over 34 REE fluorcarbonate minerals currently identified, however bastnäsite, synchysite and parisite are of most economic importance. Bastnäsite-(Ce), the most common REE fluorcarbonate, supplies over 50% of the world's REE. Previous studies of bastnäsite have showed a wide range of surface behaviour, with the iso-electric point (IEP), being measured between pH values of 4.6 and 9.3. In contrast, no values of IEP have been reported for parisite or synchysite. In this work, we review previous studies of the zeta potentials of bastnäsite to investigate the effects of different methodologies and sample preparation. In addition, measurements of zeta potentials of parisite under water, collector and supernatant conditions were conducted, the first to be reported. These results showed an iso-electric point for parisite of 5.6 under water, with a shift to a more negative zeta potential with both collector (hydroxamic and fatty acids) and supernatant conditions. The IEP with collectors and supernatant was <3.5. As zeta potential measurements in the presence of reagents and supernatants are the most rigorous way of determining the efficiency of a flotation reagent, the agreement between parisite zeta potentials obtained here and previous work on bastnäsite suggests that parisite may be processed using similar reagent schemes to

  8. Interaction between ropinirole hydrochloride and aspirin with human serum albumin as binary and ternary systems by multi-spectroscopic, molecular modeling and zeta potential

    International Nuclear Information System (INIS)

    Mahaki, Hanie; Memarpoor-Yazdi, Mina; Chamani, Jamshidkhan; Reza Saberi, Mohammad

    2013-01-01

    The aim of the present study was to describe the competition of ropinirole hydrochloride (RP) and aspirin (ASA) in binding to human serum albumin (HSA) in physiological buffer (pH=7.4) using multi-spectroscopic, molecular modeling and zeta-potential measurements. Fluorescence analysis was used to define the binding and quenching properties of drug-HSA complexes in binary and ternary systems. Fluorescence spectroscopy showed that in the presence of RP, the binding constant of HSA–ASA was increased. Static quenching was confirmed to result in the fluorescence quenching and FRET. The effect of drugs on the conformation of HSA was analyzed using synchronous fluorescence spectroscopy, three-dimensional fluorescence spectra and circular dichroism (CD). The RLS method determined the critical aggregation concentration of drugs on HSA in binary and ternary systems that confirmed the zeta potential results. Structural modeling showed that the affinity of each of the drugs to HSA in binary and ternary systems confirms the spectroscopic results. - Highlights: ► We studied the interaction of ropinirole hydrochloride and aspirin with HSA. ► Molecular modeling and zeta-potential used to describe competitive interaction. ► We determined the critical induced aggregation concentration of both drugs on HSA. ► The binding mechanism of drugs as separate and simultaneous to HSA has been compared. ► The binding site of both drugs as simultaneous effects on HSA has been determined.

  9. Interaction between ropinirole hydrochloride and aspirin with human serum albumin as binary and ternary systems by multi-spectroscopic, molecular modeling and zeta potential

    Energy Technology Data Exchange (ETDEWEB)

    Mahaki, Hanie, E-mail: hanieh.mahaki@gmail.com [Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of); Memarpoor-Yazdi, Mina; Chamani, Jamshidkhan [Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of); Reza Saberi, Mohammad [Medical Chemistry Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of)

    2013-02-15

    The aim of the present study was to describe the competition of ropinirole hydrochloride (RP) and aspirin (ASA) in binding to human serum albumin (HSA) in physiological buffer (pH=7.4) using multi-spectroscopic, molecular modeling and zeta-potential measurements. Fluorescence analysis was used to define the binding and quenching properties of drug-HSA complexes in binary and ternary systems. Fluorescence spectroscopy showed that in the presence of RP, the binding constant of HSA-ASA was increased. Static quenching was confirmed to result in the fluorescence quenching and FRET. The effect of drugs on the conformation of HSA was analyzed using synchronous fluorescence spectroscopy, three-dimensional fluorescence spectra and circular dichroism (CD). The RLS method determined the critical aggregation concentration of drugs on HSA in binary and ternary systems that confirmed the zeta potential results. Structural modeling showed that the affinity of each of the drugs to HSA in binary and ternary systems confirms the spectroscopic results. - Highlights: Black-Right-Pointing-Pointer We studied the interaction of ropinirole hydrochloride and aspirin with HSA. Black-Right-Pointing-Pointer Molecular modeling and zeta-potential used to describe competitive interaction. Black-Right-Pointing-Pointer We determined the critical induced aggregation concentration of both drugs on HSA. Black-Right-Pointing-Pointer The binding mechanism of drugs as separate and simultaneous to HSA has been compared. Black-Right-Pointing-Pointer The binding site of both drugs as simultaneous effects on HSA has been determined.

  10. Reduced Zeta potential through use of cationic adhesion promoter for improved resist process performance and minimizing material consumption

    Science.gov (United States)

    Hodgson, Lorna; Thompson, Andrew

    2012-03-01

    This paper presents the results of a non-HMDS (non-silane) adhesion promoter that was used to reduce the zeta potential for very thin (proprietary) polymer on silicon. By reducing the zeta potential, as measured by the minimum sample required to fully coat a wafer, the amount of polymer required to coat silicon substrates was significantly reduced in the manufacture of X-ray windows used for high transmission of low-energy X-rays. Moreover, this approach used aqueous based adhesion promoter described as a cationic surface active agent that has been shown to improve adhesion of photoresists (positive, negative, epoxy [SU8], e-beam and dry film). As well as reducing the amount of polymer required to coat substrates, this aqueous adhesion promoter is nonhazardous, and contains non-volatile solvents.

  11. Flotation of algae for water reuse and biomass production: role of zeta potential and surfactant to separate algal particles.

    Science.gov (United States)

    Kwak, Dong-Heui; Kim, Mi-Sug

    2015-01-01

    The effect of chemical coagulation and biological auto-flocculation relative to zeta potential was examined to compare flotation and sedimentation separation processes for algae harvesting. Experiments revealed that microalgae separation is related to auto-flocculation of Anabaena spp. and requires chemical coagulation for the whole period of microalgae cultivation. In addition, microalgae separation characteristics which are associated with surfactants demonstrated optimal microalgae cultivation time and separation efficiency of dissolved CO2 flotation (DCF) as an alternative to dissolved air flotation (DAF). Microalgae were significantly separated in response to anionic surfactant rather than cationic surfactant as a function of bubble size and zeta potential. DAF and DCF both showed slightly efficient flotation; however, application of anionic surfactant was required when using DCF.

  12. Visualizing the transient electroosmotic flow and measuring the zeta potential of microchannels with a micro-PIV technique.

    Science.gov (United States)

    Yan, Deguang; Nguyen, Nam-Trung; Yang, Chun; Huang, Xiaoyang

    2006-01-14

    We have demonstrated a transient micro particle image velocimetry (micro-PIV) technique to measure the temporal development of electroosmotic flow in microchannels. Synchronization of different trigger signals for the laser, the CCD camera, and the high-voltage switch makes this measurement possible with a conventional micro-PIV setup. Using the transient micro-PIV technique, we have further proposed a method on the basis of inertial decoupling between the particle electrophoretic motion and the fluid electroosmotic flow to determine the electrophoretic component in the particle velocity and the zeta potential of the channel wall. It is shown that using the measured zeta potentials, the theoretical predictions agree well with the transient response of the electroosmotic velocities measured in this work.

  13. The effect of the electrical double layer on hydrodynamic lubrication: a non-monotonic trend with increasing zeta potential

    Directory of Open Access Journals (Sweden)

    Dalei Jing

    2017-07-01

    Full Text Available In the present study, a modified Reynolds equation including the electrical double layer (EDL-induced electroviscous effect of lubricant is established to investigate the effect of the EDL on the hydrodynamic lubrication of a 1D slider bearing. The theoretical model is based on the nonlinear Poisson–Boltzmann equation without the use of the Debye–Hückel approximation. Furthermore, the variation in the bulk electrical conductivity of the lubricant under the influence of the EDL is also considered during the theoretical analysis of hydrodynamic lubrication. The results show that the EDL can increase the hydrodynamic load capacity of the lubricant in a 1D slider bearing. More importantly, the hydrodynamic load capacity of the lubricant under the influence of the EDL shows a non-monotonic trend, changing from enhancement to attenuation with a gradual increase in the absolute value of the zeta potential. This non-monotonic hydrodynamic lubrication is dependent on the non-monotonic electroviscous effect of the lubricant generated by the EDL, which is dominated by the non-monotonic electrical field strength and non-monotonic electrical body force on the lubricant. The subject of the paper is the theoretical modeling and the corresponding analysis.

  14. Zeta potential study of Sb2S3 nanoparticles synthesized by a facile polyol method in various surfactants

    Science.gov (United States)

    Saxena, Monika; Okram, Gunadhor Singh

    2018-05-01

    In the present work, we report the successful synthesis of stibnite Sb2S3 nanoparticles (NPs) by a facile polyol method using various surfactant. The structural and optical properties were investigated by X-ray diffraction (XRD), Raman spectroscopy and Zeta potential. Rietveld refinement of XRD data confirms the single phase orthorhombic crystal structure of stibnite Sb2S3. Presence of six obvious Raman modes further confirmed their stoichiometric formation. Effect of different surfactants on the surface charge of Sb2S3 NPs was studied using Zeta potential measurement in deionized water at different pH values. They reveal that these NPs are more stable when it was synthesized in presence of EDTA than that of CTAB or without surfactant samples with high zeta potential. The isoelectronic point was found at pH = 6.4 for pure sample, 3.5 and 7.2 for CTAB and not found for EDTA Sb2S3 samples. This information can be useful for many industrial applications like pharmaceuticals, ceramics, waste water treatment and medicines.

  15. Towards the Development of Global Nano-Quantitative Structure–Property Relationship Models: Zeta Potentials of Metal Oxide Nanoparticles

    Directory of Open Access Journals (Sweden)

    Andrey A. Toropov

    2018-04-01

    Full Text Available Zeta potential indirectly reflects a charge of the surface of nanoparticles in solutions and could be used to represent the stability of the colloidal solution. As processes of synthesis, testing and evaluation of new nanomaterials are expensive and time-consuming, so it would be helpful to estimate an approximate range of properties for untested nanomaterials using computational modeling. We collected the largest dataset of zeta potential measurements of bare metal oxide nanoparticles in water (87 data points. The dataset was used to develop quantitative structure–property relationship (QSPR models. Essential features of nanoparticles were represented using a modified simplified molecular input line entry system (SMILES. SMILES strings reflected the size-dependent behavior of zeta potentials, as the considered quasi-SMILES modification included information about both chemical composition and the size of the nanoparticles. Three mathematical models were generated using the Monte Carlo method, and their statistical quality was evaluated (R2 for the training set varied from 0.71 to 0.87; for the validation set, from 0.67 to 0.82; root mean square errors for both training and validation sets ranged from 11.3 to 17.2 mV. The developed models were analyzed and linked to aggregation effects in aqueous solutions.

  16. Interlaboratory comparison for the measurement of particle size and zeta potential of silica nanoparticles in an aqueous suspension

    Science.gov (United States)

    Lamberty, Andrée; Franks, Katrin; Braun, Adelina; Kestens, Vikram; Roebben, Gert; Linsinger, Thomas P. J.

    2011-12-01

    The Institute for Reference Materials and Measurements has organised an interlaboratory comparison (ILC) to allow the participating laboratories to demonstrate their proficiency in particle size and zeta potential measurements on monomodal aqueous suspensions of silica nanoparticles in the 10-100 nm size range. The main goal of this ILC was to identify competent collaborators for the production of certified nanoparticle reference materials. 38 laboratories from four different continents participated in the ILC with different methods for particle sizing and determination of zeta potential. Most of the laboratories submitted particle size results obtained with centrifugal liquid sedimentation (CLS), dynamic light scattering (DLS) or electron microscopy (EM), or zeta potential values obtained via electrophoretic light scattering (ELS). The results of the laboratories were evaluated using method-specific z scores, calculated on the basis of consensus values from the ILC. For CLS (13 results) and EM (13 results), all reported values were within the ±2 | z| interval. For DLS, 25 of the 27 results reported were within the ±2 | z| interval, the two other results were within the ±3 | z| interval. The standard deviations of the corresponding laboratory mean values varied between 3.7 and 6.5%, which demonstrates satisfactory interlaboratory comparability of CLS, DLS and EM particle size values. From the received test reports, a large discrepancy was observed in terms of the laboratory's quality assurance systems, which are equally important for the selection of collaborators in reference material certification projects. Only a minority of the participating laboratories is aware of all the items that are mandatory in test reports compliant to ISO/IEC 17025 (ISO General requirements for the competence of testing and calibration laboratories. International Organisation for Standardization, Geneva, 2005b). The absence of measurement uncertainty values in the reports, for

  17. Interaction of cement model systems with superplasticizers investigated by atomic force microscopy, zeta potential, and adsorption measurements.

    Science.gov (United States)

    Ferrari, Lucia; Kaufmann, Josef; Winnefeld, Frank; Plank, Johann

    2010-07-01

    Polyelectrolyte-based dispersants are commonly used in a wide range of industrial applications to provide specific workability to colloidal suspensions. Their working mechanism is based on adsorption onto the surfaces of the suspended particles. The adsorbed polymer layer can exercise an electrostatic and/or a steric effect which is responsible for achieving dispersion. This study is focused on the dispersion forces induced by polycarboxylate ether-based superplasticizers (PCEs) commonly used in concrete. They are investigated by atomic force microscopy (AFM) applying standard silicon nitride tips exposed to solutions with different ionic compositions in a wet cell. Adsorption isotherms and zeta potential analysis were performed to characterize polymer displacement in the AFM system on nonreactive model substrates (quartz, mica, calcite, and magnesium oxide) in order to avoid the complexity of cement hydration products. The results show that PCE is strongly adsorbed by positively charged materials. This fact reveals that, being silicon nitride naturally positively charged, in most cases the superplasticizer adsorbs preferably on the silicon nitride tip than on the AFM substrate. However, the force-distance curves displayed repulsive interactions between tip and substrates even when polymer was poorly adsorbed on both. These observations allow us to conclude that the dispersion due to PCE strongly depends on the particle charge. It differs between colloids adsorbing and not adsorbing PCE, and leads to different forces acting between the particles. Copyright 2010 Elsevier Inc. All rights reserved.

  18. The influence of zeta potential and yield stress on the filtration characteristics of a magnesium hydroxide simulant

    International Nuclear Information System (INIS)

    Biggs, Simon; Nabi, Rafiq; Poole, Colin; Patel, Ashok

    2007-01-01

    In the UK, irradiated fuels from Magnox reactors are often stored in water-filled ponds under alkaline conditions, so as to minimise corrosion of fuel cladding. This is important to prevent or reduce leakage of soluble fission products and actinides to the pond water. A variety of intermediate level wastes derived from Magnox materials are stored at power stations. Under these alkaline conditions, various species of magnesium are formed, of which magnesium hydroxide is the dominant material. The particle-fluid interactions are significant for the design and operation of facilities for hydraulic retrieval, filtration, dewatering and ion exchange treatment of fuel storage pond water and stored wet Magnox wastes. Here we describe a study of particulate properties and filtration characteristics of oxide particle simulants under laboratory conditions. Cake and medium resistance data were correlated across a range of pH conditions with electro-acoustic zeta potential and shear yield stress measurements, as a function of particle volume fractions. The influence of zeta potential on filtration properties arises directly from the interaction of particles within the sediment cake. (authors)

  19. Improving the Efficiency of a Coagulation-Flocculation Wastewater Treatment of the Semiconductor Industry through Zeta Potential Measurements

    Directory of Open Access Journals (Sweden)

    Eduardo Alberto López-Maldonado

    2014-01-01

    Full Text Available Efficiency of coagulation-flocculation process used for semiconductor wastewater treatment was improved by selecting suitable conditions (pH, polyelectrolyte type, and concentration through zeta potential measurements. Under this scenario the zeta potential, ζ, is the right parameter that allows studying and predicting the interactions at the molecular level between the contaminants in the wastewater and polyelectrolytes used for coagulation-flocculation. Additionally, this parameter is a key factor for assessing the efficiency of coagulation-flocculation processes based on the optimum dosages and windows for polyelectrolytes coagulation-flocculation effectiveness. In this paper, strategic pH variations allowed the prediction of the dosage of polyelectrolyte on wastewater from real electroplating baths, including the isoelectric point (IEP of the dispersions of water and commercial polyelectrolytes used in typical semiconductor industries. The results showed that there is a difference between polyelectrolyte demand required for the removal of suspended solids, turbidity, and organic matter from wastewater (23.4 mg/L and 67 mg/L, resp.. It was also concluded that the dose of polyelectrolytes and coagulation-flocculation window to achieve compliance with national and international regulations as EPA in USA and SEMARNAT in Mexico is influenced by the physicochemical characteristics of the dispersions and treatment conditions (pH and polyelectrolyte dosing strategy.

  20. Joule heating effects on electromagnetohydrodynamic flow through a peristaltically induced micro-channel with different zeta potential and wall slip

    Science.gov (United States)

    Ranjit, N. K.; Shit, G. C.

    2017-09-01

    This paper aims to develop a mathematical model for magnetohydrodynamic flow of biofluids through a hydrophobic micro-channel with periodically contracting and expanding walls under the influence of an axially applied electric field. The velocity slip effects have been taken into account at the channel walls by employing different slip lengths due to hydrophobic gating. Different temperature jump factors have also been used to investigate the thermomechanical interactions at the fluid-solid interface. The electromagnetohydrodynamic flow in a microchannel is simplified under the framework of Debye-Hückel linearization approximation. We have derived the closed-form solutions for the linearized dimensionless boundary value problem under the assumptions of long wave length and low Reynolds number. The axial velocity, temperature, pressure distribution, stream function, wall shear stress and the Nusselt number have been appraised for diverse values of the parameters approaching into the problem. Our main focus is to determine the effects of different zeta potential on the axial velocity and temperature distribution under electromagnetic environment. This study puts forward an important observation that the different zeta potential plays an important role in controlling fluid velocity. The study further reveals that the temperature increases significantly with the Joule heating parameter and the Brinkman number (arises due to the dissipation of energy).

  1. Adsorbed polymers in aqueous media. The relation between zeta-potential, layer thickness and ionic strength

    NARCIS (Netherlands)

    Cohen Stuart, M.A.; Mulder, J.W.

    1985-01-01

    Streaming potentials for glass capillaries with and without adsorbed poly(vinyl pyrrolidone) were used to determine the thickness of the adsorbed polymer layer. It was found that the thickness determined in this way is a strong function of the ionic strength of the solution. The results are compared

  2. Effect of hydrodynamic slippage on electro-osmotic flow in zeta potential patterned nanochannels

    Energy Technology Data Exchange (ETDEWEB)

    Datta, S; Choudhary, J N, E-mail: subhra-datta@iitd.ac.in [Department of Mechanical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016 (India)

    2013-10-01

    The effect of hydrodynamic slippage on the electro-osmotic flow in a nanochannel with thick electrical double layers whose wall surface potential has a periodic axial variation is studied. The equations of Stokes flow are solved exactly with the help of the Navier slip boundary condition and the Debye-Huckel linearization of the equation governing the potential of the electrical double layer. Each periodic cell of the flow field consists of four counter-rotating vortices. The cross-channel profile of the axial velocity at the center of the cell exhibits three extrema and a reversed velocity zone near the channel axis of symmetry. The size of the extrema and that of the reversed velocity zone increases with increase in the degree of slippage. In the limit when the wavelength of axial variation in surface potential is much larger than the channel width, the flow characteristics are interpreted in terms of the lubrication approximation. In the limit when the electrical double layer is much thinner than the channel height, the effect of slip is modeled by a Helmholtz-Smoluchowski apparent slip boundary condition that depends on the pattern wavelength. (paper)

  3. Positive zeta potential of a negatively charged semi-permeable plasma membrane

    Science.gov (United States)

    Sinha, Shayandev; Jing, Haoyuan; Das, Siddhartha

    2017-08-01

    The negative charge of the plasma membrane (PM) severely affects the nature of moieties that may enter or leave the cells and controls a large number of ion-interaction-mediated intracellular and extracellular events. In this letter, we report our discovery of a most fascinating scenario, where one interface (e.g., membrane-cytosol interface) of the negatively charged PM shows a positive surface (or ζ) potential, while the other interface (e.g., membrane-electrolyte interface) still shows a negative ζ potential. Therefore, we encounter a completely unexpected situation where an interface (e.g., membrane-cytosol interface) that has a negative surface charge density demonstrates a positive ζ potential. We establish that the attainment of such a property by the membrane can be ascribed to an interplay of the nature of the membrane semi-permeability and the electrostatics of the electric double layer established on either side of the charged membrane. We anticipate that such a membrane property can lead to such capabilities of the cell (in terms of accepting or releasing certain kinds of moieties as well regulating cellular signaling) that was hitherto inconceivable.

  4. Use of Spectroscopic, Zeta Potential and Molecular Dynamic Techniques to Study the Interaction between Human Holo-Transferrin and Two Antagonist Drugs: Comparison of Binary and Ternary Systems

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Saberi

    2012-03-01

    Full Text Available For the first time, the binding of ropinirole hydrochloride (ROP and aspirin (ASA to human holo-transferrin (hTf has been investigated by spectroscopic approaches (fluorescence quenching, synchronous fluorescence, time-resolved fluorescence, three-dimensional fluorescence, UV-vis absorption, circular dichroism, resonance light scattering, as well as zeta potential and molecular modeling techniques, under simulated physiological conditions. Fluorescence analysis was used to estimate the effect of the ROP and ASA drugs on the fluorescence of hTf as well as to define the binding and quenching properties of binary and ternary complexes. The synchronized fluorescence and three-dimensional fluorescence spectra demonstrated some micro-environmental and conformational changes around the Trp and Tyr residues with a faint red shift. Thermodynamic analysis displayed the van der Waals forces and hydrogen bonds interactions are the major acting forces in stabilizing the complexes. Steady-state and time-resolved fluorescence data revealed that the fluorescence quenching of complexes are static mechanism. The effect of the drugs aggregating on the hTf resulted in an enhancement of the resonance light scattering (RLS intensity. The average binding distance between were computed according to the forster non-radiation energy transfer theory. The circular dichroism (CD spectral examinations indicated that the binding of the drugs induced a conformational change of hTf. Measurements of the zeta potential indicated that the combination of electrostatic and hydrophobic interactions between ROP, ASA and hTf formed micelle-like clusters. The molecular modeling confirmed the experimental results. This study is expected to provide important insight into the interaction of hTf with ROP and ASA to use in various toxicological and therapeutic processes.

  5. Effect of Tannic Acid on the zeta Potential, Sorption, and Surface Free Energy in the Process of Dyeing of Leacril with a Cationic Dye.

    Science.gov (United States)

    Espinosa-Jiménez; Giménez-Martín; Ontiveros-Ortega

    1998-11-01

    The behavior of the surface free energy in the process of dyeing Leacril pretreated with tannic acid and subsequently dyeing with the cationic dye Rhodamine B has been studied. Also the electrokinetic behavior of these systems has been analyzed by studying the zeta potential, which has been obtained by means of the streaming potential technique. Values more significative of the zeta potential of these systems have been obtained using the three models of capillaries existing in the literature. The qualitative behavior of the zeta potential is the same for the three models of capillaries tested in this paper. These models are those of Goring and Mason, Biefer and Mason, and Chang and Robertson. The zeta potential of the systems analyzed is negative in the range of concentration of the dye in the liquid phase from 10(-6) to ca. 10(-4) M of dye. In the range of low concentrations (from 10(-6) to ca. 10(-5) M of dye) the zeta potential of the system untreated Leacril/Rhodamine B increases in absolute value due to increasing hydrophobic attractions between both the hydrophobic chains of the dye and the Leacril fibers in aqueous media. In the system Leacril treated with tannic acid/Rhodamine B, this increase is also due to the presence of hydrogen bonding between the phenolic hydroxyl groups of the tannic acid and the sulfonate and sulfate end groups of Leacril fibers. For concentrations of dye between 10(-5) and 10(-4) M of dye in solution, the zeta potential decreases in absolute value due to the electrostatic attractions between the groups negatively charged in the fiber and the cation of the dye. The zeta potential changes its sign at the highest concentrations of dye used in this work. The adsorption of Rhodamine B onto both untreated Leacril and Leacril treated with tannic acid is favored by the increasing temperature of adsorption. The behavior of the components of the surface free energy obtained by the thin-layer wicking technique led us to consider that the

  6. Determination of zeta-potential, charge, and number of organic ligands on the surface of water soluble quantum dots by capillary electrophoresis

    Czech Academy of Sciences Publication Activity Database

    Voráčová, Ivona; Klepárník, Karel; Lišková, Marcela; Foret, František

    2015-01-01

    Roč. 36, č. 6 (2015), s. 867-874 ISSN 0173-0835 R&D Projects: GA ČR(CZ) GA14-28254S Institutional support: RVO:68081715 Keywords : CE * LIF * zeta-potential * quantum dots Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 2.482, year: 2015

  7. Rheology and zeta potential of cement pastes containing calcined silt and ground granulated blast-furnace slag

    Directory of Open Access Journals (Sweden)

    Safi, B.

    2011-09-01

    Full Text Available This study aimed to analyse the re-use of dam silt as a supplementary binder for self-compacting concrete (SCC. When burnt, silt becomes more reactive because the kaolin it contains is converted into metakaolin. Portland cement, calcined or burnt silt and ground granulated blast furnace slag were used in this research. Cement pastes were prepared with blends containing two or three of these materials. The replacement ratio for burnt silt in both cases was 10 % and 20 % by cement weight and the ratio for the slag was a constant 30 % by weight of the blend. Rheological and zeta potential tests were conducted to evaluate paste electrokinetics and rheological behaviour. The findings showed that burnt silt is apt for use as an addition to cement for SCC manufacture.

    En el presente trabajo se ha analizado la posibilidad de utilizar los lodos procedentes de embalses como adición en la fabricación del hormigón autocompactante (HAC. Con la calcinación, estos materiales se vuelven más reactivos debido a la transformación en metacaolín, del caolín que forma parte de su composición. Las materias primas empleadas en esta investigación son: cemento Pórtland, lodos de embalse calcinados y escorias granuladas de horno alto. Se prepararon pastas de cemento con mezclas que contenían dos o tres de estos materiales. El porcentaje de reemplazo de los lodos calcinados osciló entre el 10 y el 20 % en peso del cemento, mientras que el de la escoria fue del 30 % en peso de la mezcla. Se llevaron a cabo ensayos reológicos y de potencial zeta para evaluar el comportamiento electrocinético y reológico de las distintas pastas. De acuerdo con los resultados obtenidos, una vez calcinados, los lodos de embalse son aprovechables como adición al cemento con destino a la preparación de HAC.

  8. A zeta potential value determines the aggregate's size of penta-substituted [60]fullerene derivatives in aqueous suspension whereas positive charge is required for toxicity against bacterial cells.

    Science.gov (United States)

    Deryabin, Dmitry G; Efremova, Ludmila V; Vasilchenko, Alexey S; Saidakova, Evgeniya V; Sizova, Elena A; Troshin, Pavel A; Zhilenkov, Alexander V; Khakina, Ekaterina A; Khakina, Ekaterina E

    2015-08-08

    The cause-effect relationships between physicochemical properties of amphiphilic [60]fullerene derivatives and their toxicity against bacterial cells have not yet been clarified. In this study, we report how the differences in the chemical structure of organic addends in 10 originally synthesized penta-substituted [60]fullerene derivatives modulate their zeta potential and aggregate's size in salt-free and salt-added aqueous suspensions as well as how these physicochemical characteristics affect the bioenergetics of freshwater Escherichia coli and marine Photobacterium phosphoreum bacteria. Dynamic light scattering, laser Doppler micro-electrophoresis, agarose gel electrophoresis, atomic force microscopy, and bioluminescence inhibition assay were used to characterize the fullerene aggregation behavior in aqueous solution and their interaction with the bacterial cell surface, following zeta potential changes and toxic effects. Dynamic light scattering results indicated the formation of self-assembled [60]fullerene aggregates in aqueous suspensions. The measurement of the zeta potential of the particles revealed that they have different surface charges. The relationship between these physicochemical characteristics was presented as an exponential regression that correctly described the dependence of the aggregate's size of penta-substituted [60]fullerene derivatives in salt-free aqueous suspension from zeta potential value. The prevalence of DLVO-related effects was shown in salt-added aqueous suspension that decreased zeta potential values and affected the aggregation of [60]fullerene derivatives expressed differently for individual compounds. A bioluminescence inhibition assay demonstrated that the toxic effect of [60]fullerene derivatives against E. coli cells was strictly determined by their positive zeta potential charge value being weakened against P. phosphoreum cells in an aquatic system of high salinity. Atomic force microscopy data suggested that the

  9. Electroosmotic flow in a rectangular channel with variable wall zeta-potential: comparison of numerical simulation with asymptotic theory.

    Science.gov (United States)

    Datta, Subhra; Ghosal, Sandip; Patankar, Neelesh A

    2006-02-01

    Electroosmotic flow in a straight micro-channel of rectangular cross-section is computed numerically for several situations where the wall zeta-potential is not constant but has a specified spatial variation. The results of the computation are compared with an earlier published asymptotic theory based on the lubrication approximation: the assumption that any axial variations take place on a long length scale compared to a characteristic channel width. The computational results are found to be in excellent agreement with the theory even when the scale of axial variations is comparable to the channel width. In the opposite limit when the wavelength of fluctuations is much shorter than the channel width, the lubrication theory fails to describe the solution either qualitatively or quantitatively. In this short wave limit the solution is well described by Ajdari's theory for electroosmotic flow between infinite parallel plates (Ajdari, A., Phys. Rev. E 1996, 53, 4996-5005.) The infinitely thin electric double layer limit is assumed in the theory as well as in the simulation.

  10. An application of zeta potential method for the selection of nano-fluids to enhance IVR capability

    International Nuclear Information System (INIS)

    Pham Quynh Trang; Kim, Tae Il; Chang, Soon Heung

    2009-01-01

    In-vessel Retention (IVR) is one of the key severe accident management strategies that have been applied currently for advanced light water reactors such as APR1000 or APR1400. The concept of IVR consists of external cooling of the reactor vessel by flooding the reactor cavity to remove the decay heat from the molten core through the lower head of the vessel. However, the heat removal process is limited by the occurrence of critical heat flux (CHF) at the reactor vessel outer surface that may lead to a sharp increase of local temperature, damaging the integrity of the reactor vessel. In order to obtain higher power of nuclear reactors and to assure the achievement of the IVR capability during accident conditions, an enhancement of CHF at the outer surface of the vessel is required. The potential use of nano-fluids to increase the CHF is among the main IVR enhancing approaches. In this study, Al 2 O 3 and CNT nano-fluids with different concentrations have been used as the potential coolant to enhance IVR capabilities. The dispersion stability of the nano-fluids was verified by zeta potential measurements. The results showed effects of time, concentration and pH on the stability of nanofluids. Three types of nano-fluids were selected as the candidates to apply for the IVR. A series of experiments have been performed in this study to understand the pool-boiling critical heat flux behavior on downward facing surfaces submerged in a pool of nano-fluids at very low concentration. The inclination angle was changed from horizontal to vertical to investigate the effect of orientation on CHF enhancement which is needed for the application in IVR

  11. Unfolding of hemoglobin variants--insights from urea gradient gel electrophoresis photon correlation spectroscopy and zeta potential measurements

    International Nuclear Information System (INIS)

    Bhattacharya, Jaydeep; GhoshMoulick, Ranjita; Choudhuri, Utpal; Chakrabarty, Prantar; Bhattacharya, Pranab K.; Lahiri, Prabir; Chakraborti, Bikas; Dasgupta, Anjan Kr.

    2004-01-01

    The unfolding pattern of crystal human hemoglobin and variants of hemoglobin obtained from hemolysate were studied using transverse urea gradient gel electrophoresis (TUGGE). A smooth sigmoid like increase of electrophoretic mobility was observed with increasing urea concentrations. A decrease in electrophoretic mobility resulted, if the protein was unfolded with guanidium hydrochloride (GdnHCl). The anomaly was resolved after the Stoke's radii (obtained using the photon correlation spectroscopy) and zeta potential (measured using laser Doppler velocimetry) measurements were made at different denaturant concentrations. Addition of denaturant led to formation of extended structure, irrespective of the nature of the denaturant, as indicated by increase in Stoke's radii in both cases (urea and GdnHCl). The unexpected increase in electrophoretic mobility in case of urea could be explained in terms of a critical redistribution of negative charge at intermediate stages of the unfolding process. In case of GdnHCl, the higher ionic strength masked the charge effect. The mobility, being solely dependent on size, decreased at higher denaturant concentration. Incidentally, folding loci of other hemoglobin variants (e.g. HbE) or that of post-translationally modified hemoglobin (e.g. HbA1c) could be determined by studying the charge distribution and hydrodynamic radius at varying denaturing stress and in each case the gel migration profile could be approximately scaled by the ratio of charge and hydrodynamic diameter of the protein. While unfolding induced charge effect was most pronounced in HbA0 (and crystal ferrous hemoglobin), the unfolding induced aggregation (manifested by the increase in Stoke's radii) was predominantly observed in the variant forms HbE and HbA1c. Representing the proteins by a plot, in which charge and hydrodynamic diameter are on independent axes, may be a useful way of characterizing protein variants having similar migration profiles on native gels

  12. Unfolding of hemoglobin variants--insights from urea gradient gel electrophoresis photon correlation spectroscopy and zeta potential measurements

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Jaydeep; GhoshMoulick, Ranjita; Choudhuri, Utpal; Chakrabarty, Prantar; Bhattacharya, Pranab K.; Lahiri, Prabir; Chakraborti, Bikas; Dasgupta, Anjan Kr

    2004-09-27

    The unfolding pattern of crystal human hemoglobin and variants of hemoglobin obtained from hemolysate were studied using transverse urea gradient gel electrophoresis (TUGGE). A smooth sigmoid like increase of electrophoretic mobility was observed with increasing urea concentrations. A decrease in electrophoretic mobility resulted, if the protein was unfolded with guanidium hydrochloride (GdnHCl). The anomaly was resolved after the Stoke's radii (obtained using the photon correlation spectroscopy) and zeta potential (measured using laser Doppler velocimetry) measurements were made at different denaturant concentrations. Addition of denaturant led to formation of extended structure, irrespective of the nature of the denaturant, as indicated by increase in Stoke's radii in both cases (urea and GdnHCl). The unexpected increase in electrophoretic mobility in case of urea could be explained in terms of a critical redistribution of negative charge at intermediate stages of the unfolding process. In case of GdnHCl, the higher ionic strength masked the charge effect. The mobility, being solely dependent on size, decreased at higher denaturant concentration. Incidentally, folding loci of other hemoglobin variants (e.g. HbE) or that of post-translationally modified hemoglobin (e.g. HbA1c) could be determined by studying the charge distribution and hydrodynamic radius at varying denaturing stress and in each case the gel migration profile could be approximately scaled by the ratio of charge and hydrodynamic diameter of the protein. While unfolding induced charge effect was most pronounced in HbA0 (and crystal ferrous hemoglobin), the unfolding induced aggregation (manifested by the increase in Stoke's radii) was predominantly observed in the variant forms HbE and HbA1c. Representing the proteins by a plot, in which charge and hydrodynamic diameter are on independent axes, may be a useful way of characterizing protein variants having similar migration profiles on

  13. Zeta-potential data reliability of gold nanoparticle biomolecular conjugates and its application in sensitive quantification of surface absorbed protein.

    Science.gov (United States)

    Wang, Wenjie; Ding, Xiaofan; Xu, Qing; Wang, Jing; Wang, Lei; Lou, Xinhui

    2016-12-01

    Zeta potentials (ZP) of gold nanoparticle bioconjugates (AuNP-bios) provide important information on surface charge that is critical for many applications including drug delivery, biosensing, and cell imaging. The ZP measurements (ZPMs) are conducted under an alternative electrical field at a high frequency under laser irradiation, which may strongly affect the status of surface coating of AuNP-bios and generate unreliable data. In this study, we systemically evaluated the ZP data reliability (ZPDR) of citrate-, thiolated single stranded DNA-, and protein-coated AuNPs mainly according to the consistence of ZPs in the repeated ZPMs and the changes of the hydrodynamic size before and after the ZPMs. We found that the ZPDR was highly dependent on both buffer conditions and surface modifications. Overall, the higher ionic strength of the buffer and the lower affinity of surface bounders were related with the worse ZPDR. The ZPDR of citrate-coated AuNP was good in water, but bad in 10mM phosphate buffer (PB), showing substantially decrease of the absolute ZP values after each measurement, probably due to the electrical field facilitated adsorption of negatively charged phosphate ions on AuNPs. The significant desorption of DNAs from AuNP was observed in the PB containing medium concentration of NaCl, but not in PB. The excellent ZPDR of bovine serum albumin (BSA)-coated AuNP was observed at high salt concentrations and low surface coverage, enabling ZPM as an ultra-sensitive tool for protein quantification on the surface of AuNPs with a single molecule resolution. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Cell surface groups of two picocyanobacteria strains studied by zeta potential investigations, potentiometric titration, and infrared spectroscopy.

    Science.gov (United States)

    Dittrich, Maria; Sibler, Sabine

    2005-06-15

    In order to clarify the role of picocyanobacteria in aquatic biogeochemical processes (e.g., calcite precipitation), cell surface properties need to be investigated. An experimental study of the cell surface characteristics of two Synechococcus-type unicellular autotrophic picocyanobacterial strains was carried out. One strain was isolated from Lake Plon and contained phycocyanin, the other strain came from Lago Maggiore and was rich in phycoerythrin. Potentiometric titrations were conducted to determine the different types of sites present on the bacteria cell walls. Infrared spectroscopy allowed characterization of the various functional groups (RNH(2), RCOOH, ROH, RPO(2)) and investigations of zeta potential provided insight into the isoelectrical points of the strains. Titrations reveal three distinct sites on the bacterial surfaces of phycocyanin- and phycoerythrin-rich strains with pK values of 4.8+/-0.3/5.0+/-0.2, 6.6+/-0.2/6.7+/-0.4, and 8.8+/-0.1/8.7+/-0.2, corresponding to carboxyl, phosphate, and amine groups with surface densities of 2.6+/-0.4/7.4+/-1.6 x 10(-4), 1.9+/-0.5/4.4+/-0.8 x 10(-4), and 2.5+/-0.4/4.8+/-0.7 x 10(-4) mol/g of dry bacteria. The deprotonation constants are similar to those of bacterial strains and site densities are also within an order of magnitude of other strains. The phycoerythrin-rich strain had a higher number of binding sites than the phycocyanin-rich strain. The results showed that picocyanobacteria may adsorb either calcium cations or carbonate anions and therefore strongly influence the biogeochemical cycling of calcite in pelagic systems.

  15. Evaluating Zeta Potential and the Calcite/Aragonite Ratio as Potential Success Indicators for Magnetic Water Treatment

    National Research Council Canada - National Science Library

    Lambert, Kevin

    1999-01-01

    The potential benefits of anti-scale magnetic treatment (AMT) are not realized or reliably predicted because the factors measuring performance of magnetic treatment have either not been identified or are poorly defined...

  16. Multireference configuration interaction treatment of potential energy surfaces: symmetric dissociation of H/sub 2/O in a double-zeta basis

    Energy Technology Data Exchange (ETDEWEB)

    Brown, F B; Shavitt, I; Shepard, R

    1984-03-23

    Multiconfiguration self-consistent fields (SCF) and multireference configurational interaction (CI) calculations have been performed for the H/sub 2/O molecule in a double-zeta basis for four symmetric geometries, for comparison with full CI results. Unlike single-reference results, the energy errors are almost independent of geometry, allowing unbiased treatments of potential energy surfaces. 35 references, 1 figure, 2 tables.

  17. Comparison of methods of zeta potential and residual turbidity of pectin solutions using calcium sulphate/aluminium sulphate as a precipitant

    Directory of Open Access Journals (Sweden)

    Kuljanin Tatjana A.

    2017-01-01

    Full Text Available The affinity of calcium ion binding from CaO used in the most common process of purification of sugar beet juice is relatively low. Therefore, large amounts of this compound are required. This paper presents the theoretical basis of a novel sugar beet juice purification method based on the application of the binary system CaSO4/Al2(SO4 . In order to monitor the process of coagulation and precipitation of pectin in the presence of CaSO4/Al2(SO43, two methods were compared: measurement of the zeta potential and of residual solution turbidity. The zeta potential of pectin solution was determined by electrophoretic method, while the residual turbidity was determined by spectrophotometry. Two model solutions of pectin (0.1 % w/w were investigated. Studies were performed with 10 different concentrations of the binary solution CaSO4/Al2(SO43 (50 - 500 g dm-3. The amount of the precipitant CaSO4/Al2(SO43 (1:1 w/w needed to achieve the minimum solution turbidity and charge neutralization of pectin particles (zero zeta potential were measured and compared. Colloidal destabilization occurred before a complete neutralization of the surface charge of pectin particles (zeta potential ~ 0 mV. Optimal quantities (490 - 705 mg g-1 pectin of the applied binary mixture, were obtained using both methods. This is much lower than the amount of CaO that is commonly used in the conventional process of sugar beet juice purification (about 9 g• g-1 pectin. The use of these precipitants could be important from both economic and environmental point of view. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR 31055

  18. Generation of nanobubbles by ceramic membrane filters: The dependence of bubble size and zeta potential on surface coating, pore size and injected gas pressure.

    Science.gov (United States)

    Ahmed, Ahmed Khaled Abdella; Sun, Cuizhen; Hua, Likun; Zhang, Zhibin; Zhang, Yanhao; Zhang, Wen; Marhaba, Taha

    2018-07-01

    Generation of gaseous nanobubbles (NBs) by simple, efficient, and scalable methods is critical for industrialization and applications of nanobubbles. Traditional generation methods mainly rely on hydrodynamic, acoustic, particle, and optical cavitation. These generation processes render issues such as high energy consumption, non-flexibility, and complexity. This research investigated the use of tubular ceramic nanofiltration membranes to generate NBs in water with air, nitrogen and oxygen gases. This system injects pressurized gases through a tubular ceramic membrane with nanopores to create NBs. The effects of membrane pores size, surface energy, and the injected gas pressures on the bubble size and zeta potential were examined. The results show that the gas injection pressure had considerable effects on the bubble size, zeta potential, pH, and dissolved oxygen of the produced NBs. For example, increasing the injection air pressure from 69 kPa to 414 kPa, the air bubble size was reduced from 600 to 340 nm respectively. Membrane pores size and surface energy also had significant effects on sizes and zeta potentials of NBs. The results presented here aim to fill out the gaps of fundamental knowledge about NBs and development of efficient generation methods. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Interpretation of colloidal dyeing of polyester fabrics pretreated with ethyl xanthogenate in terms of zeta potential and surface free energy balance.

    Science.gov (United States)

    Espinosa-Jiménez, M; Padilla-Weigand, R; Ontiveros-Ortega, A; Ramos-Tejada, M M; Perea-Carpio, R

    2003-09-15

    Data are presented on the adsorption of the colloidal dye Disperse Blue 3 onto polyester fabric (Dacron 54, Stile 777), the fabric being pretreated with different amounts of the surfactant potassium ethyl xanthogenate (PEX). This study has been made by means of both the evolution of the zeta potential of the fiber/dye interface and the behaviour of the surface free energy components of the above systems. The kinetics of adsorption of the process of dyeing, using 10(-4) M of PEX in the pretreatment of the fabric, shows that increasing temperature of adsorption decrease the amount of colloidal dye adsorbed onto the fabric. This fact shows that the principal mechanism involved in this adsorption process is physical in nature. The adsorption isotherms of the colloidal dye onto polyester pretreated with different amounts of PEX, shows that the adsorption of the dye is favored with the increase in the concentration of the surfactant used in the pretreatment. This fact shows that the pretreatment with PEX is a very interesting aspect of interest in textile industry. The zeta potential of the system fabric/surfactant shows that this parameter is negative (about -25 mV) for the untreated fiber and decreases in absolute value for increasing concentration of the surfactant on the fiber, the value of the zeta potential of the system being -5 mV for 10(-2) M of PEX. This behavior can be explained for the chemical reaction nucleophilic attack between the carboxyl groups of polyester, ionized at pH 8, and the thiocarbonyl group of the xanthogenate ion. On the other hand, the zeta potential of the system polyester pretreated with PEX/Disperse Blue 3 at increasing concentrations of the surfactant and the dye shows that this parameter increases its negative value strongly with increasing concentration of the surfactant used in the treatment. This can be explained for the hydrogen bonds between the hydroxy groups of the dye and the S- ions of the thiocarbonyl group of the surfactant

  20. Characterization of the startup transient electrokinetic flow in rectangular channels of arbitrary dimensions, zeta potential distribution, and time-varying pressure gradient.

    Science.gov (United States)

    Miller, Andrew; Villegas, Arturo; Diez, F Javier

    2015-03-01

    The solution to the startup transient EOF in an arbitrary rectangular microchannel is derived analytically and validated experimentally. This full 2D transient solution describes the evolution of the flow through five distinct periods until reaching a final steady state. The derived analytical velocity solution is validated experimentally for different channel sizes and aspect ratios under time-varying pressure gradients. The experiments used a time resolved micro particle image velocimetry technique to calculate the startup transient velocity profiles. The measurements captured the effect of time-varying pressure gradient fields derived in the analytical solutions. This is tested by using small reservoirs at both ends of the channel which allowed a time-varying pressure gradient to develop with a time scale on the order of the transient EOF. Results showed that under these common conditions, the effect of the pressure build up in the reservoirs on the temporal development of the transient startup EOF in the channels cannot be neglected. The measurements also captured the analytical predictions for channel walls made of different materials (i.e., zeta potentials). This was tested in channels that had three PDMS and one quartz wall, resulting in a flow with an asymmetric velocity profile due to variations in the zeta potential between the walls. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Mixtures of latex particles and the surfactant of opposite charge used as interface stabilizers--influence of particle contact angle, zeta potential, flocculation and shear energy.

    Science.gov (United States)

    Deleurence, Rémi; Parneix, Caroline; Monteux, Cécile

    2014-09-28

    We investigate the stabilization of air-water interfaces by mixtures of negatively charged latex particles (sulfate polystyrene) and cationic surfactants (alkyl trimethylammonium bromides). First we report results concerning the binding of surfactant molecules to the latex particles. As the surfactant concentration increases, the charge of the particles reverses, from negative to positive, because CnTAB first binds electrostatically to the latex particles and then through hydrophobic interaction with the monolayer already adsorbed on the particles as well as directly with the hydrophobic surface of the latex. Over a large range of surfactant concentrations around the charge inversion, a strong flocculation is observed and 100 μm large aggregates form in the suspension. Unlike previous studies published on mixtures of inorganic particles with oppositely charged surfactants, we show that we can vary the sign of the zeta potential of the particles without changing the contact angle of the particles over a large range of surfactant concentrations. Indeed, the latex particles that we study are more hydrophobic than inorganic particles, hence adding moderate concentrations of the surfactant results in a weak variation of the contact angle while the charge of the particles can be reversed. This enables decoupling of the effect of zeta potential and contact angle on the interfacial properties of the mixtures. Our study shows that the contact angle and the charge of the particles are not sufficient parameters to control the foam properties, and the key-parameters are the flocculation state and the shear energy applied to produce the foam. Indeed, flocculated samples, whatever the sign of the zeta potential, enable production of a stable armour at the interface. The large aggregates do not adsorb spontaneously at the interface because of their large size, however when a large shear energy is used to produce the foam very stable foam is obtained, where particles are trapped

  2. Wind models for zeta Orionis

    International Nuclear Information System (INIS)

    Olson, G.L.

    1979-01-01

    Several models for the winds of O stars have been proposed to explain the unexpected presence of high ionization potential ions such as N +4 and O +5 . Lamers and Snow (1978) proposed that the winds of stars showing N V and O VI lines have elevated temperatures near 4 +- 2 x 10 5 K while cooler stars with anomalous Si IV lines have Tsub(e) approximately 7+-3 x 10 4 K. Alternately, Cassinelli and Olson (1978, CO) and Olson (1978) have explained the presence of these ions by showing that a thin corona at the base of a cool wind (Tsub(e) < approximately Tsub(eff)) can produce these ions by the Auger photoionization process where a single X-ray photon causes the ejection of two electrons. A third possibility is that the winds are at only slightly elevated temperatures (40 000 to 60 000K) and photoionization in an optically thick wind produces the unexpected ions. The present analysis tests the ability of these three wind models to fit the observations of zeta Orionis A 09.7 Ib. (Auth.)

  3. Riemann zeta function from wave-packet dynamics

    DEFF Research Database (Denmark)

    Mack, R.; Dahl, Jens Peder; Moya-Cessa, H.

    2010-01-01

    We show that the time evolution of a thermal phase state of an anharmonic oscillator with logarithmic energy spectrum is intimately connected to the generalized Riemann zeta function zeta(s, a). Indeed, the autocorrelation function at a time t is determined by zeta (sigma + i tau, a), where sigma...... index of JWKB. We compare and contrast exact and approximate eigenvalues of purely logarithmic potentials. Moreover, we use a numerical method to find a potential which leads to exact logarithmic eigenvalues. We discuss possible realizations of Riemann zeta wave-packet dynamics using cold atoms...

  4. Stability Investigation of Ligand-Exchanged CdSe/ZnS-Y (Y = 3-Mercaptopropionic Acid or Mercaptosuccinic Acid through Zeta Potential Measurements

    Directory of Open Access Journals (Sweden)

    Ngoc Thuy Vo

    2016-01-01

    Full Text Available Quantum dots have been considered to be promising candidates for bioapplications because of their high sensitivity, rapid response, and reliability. The synthesis of high-quality quantum dots that can be dissolved in water and other biological media is a crucial step toward their further application in biology. Starting with a one-pot reaction and the successive ionic layer adsorption and reaction (SILAR method, we produced the CdSe/ZnS core/shell structure. Through a ligand-exchange mechanism, we coated the as-made CdSe/ZnS structure with 3-mercaptopropionic acid (MPA or mercaptosuccinic acid (MSA. Various techniques, including photoluminescence (PL, ultraviolet-visible (UV-Vis spectroscopy, transmission electron microscopy (TEM, X-ray diffraction (XRD, and Fourier transform infrared (FTIR spectroscopy, were utilized to characterize the ligand-coated CdSe/ZnS structure. The results show enhanced luminescence intensity, CdSe surface passivation by ZnS, and successful coating with MPA and MSA. The stability of quantum dots in solutions with different pH values was investigated by performing zeta potential measurements. The results revealed that the quantum dots shifted from displaying hydrophobic to hydrophilic behavior and could be connected with bioagents.

  5. The preparation, surface structure, zeta potential, surface charge density and photocatalytic activity of TiO2 nanostructures of different shapes

    International Nuclear Information System (INIS)

    Grover, Inderpreet Singh; Singh, Satnam; Pal, Bonamali

    2013-01-01

    Titania based nanocatalysts such as sodium titanates of different morphology having superior surface properties are getting wide importance in photocatalysis research. Despite having sodium (Na) contents and its high temperature synthesis (that generally deteriorate the photoreactivity), these Na-titanates often exhibit better photoactivity than P25-TiO 2 catalyst. Hence, this work demonstrated the influence of crystal structure, BET surface area, surface charge, zeta potential (ζ) and metal loading on the photocatalytic activity of as-prepared sodium titanate nanotube (TNT) and titania nanorod (TNR). Straw like hollow orthorhombic-TNT (Na 2 Ti 2 O 5 ·H 2 O) particles (W = 9–12 nm and L = 82–115 nm) and rice like pure anatase-TNR particles (W = 8–13 nm and L = 81–134 nm) are obtained by the hydrothermal treatment of P25-TiO 2 with NaOH, which in fact, altered the net surface charge of TNT and TNR particles. The observed ζ = −2.82 (P25-TiO 2 ), −13.5 (TNT) and −22.5 mV (TNR) are significantly altered by the Ag and Cu deposition. It has been found here that TNT displayed best photocatalytic activity for the imidacloprid insecticide (C 9 H 10 ClN 5 O 2 ) degradation to CO 2 formation under UV irradiation because of its largest surface area 176 m 2 g −1 among the catalysts studied.

  6. The preparation, surface structure, zeta potential, surface charge density and photocatalytic activity of TiO2 nanostructures of different shapes

    Science.gov (United States)

    Grover, Inderpreet Singh; Singh, Satnam; Pal, Bonamali

    2013-09-01

    Titania based nanocatalysts such as sodium titanates of different morphology having superior surface properties are getting wide importance in photocatalysis research. Despite having sodium (Na) contents and its high temperature synthesis (that generally deteriorate the photoreactivity), these Na-titanates often exhibit better photoactivity than P25-TiO2 catalyst. Hence, this work demonstrated the influence of crystal structure, BET surface area, surface charge, zeta potential (ζ) and metal loading on the photocatalytic activity of as-prepared sodium titanate nanotube (TNT) and titania nanorod (TNR). Straw like hollow orthorhombic-TNT (Na2Ti2O5·H2O) particles (W = 9-12 nm and L = 82-115 nm) and rice like pure anatase-TNR particles (W = 8-13 nm and L = 81-134 nm) are obtained by the hydrothermal treatment of P25-TiO2 with NaOH, which in fact, altered the net surface charge of TNT and TNR particles. The observed ζ = -2.82 (P25-TiO2), -13.5 (TNT) and -22.5 mV (TNR) are significantly altered by the Ag and Cu deposition. It has been found here that TNT displayed best photocatalytic activity for the imidacloprid insecticide (C9H10ClN5O2) degradation to CO2 formation under UV irradiation because of its largest surface area 176 m2 g-1 among the catalysts studied.

  7. The preparation, surface structure, zeta potential, surface charge density and photocatalytic activity of TiO{sub 2} nanostructures of different shapes

    Energy Technology Data Exchange (ETDEWEB)

    Grover, Inderpreet Singh; Singh, Satnam; Pal, Bonamali, E-mail: bpal@thapar.edu

    2013-09-01

    Titania based nanocatalysts such as sodium titanates of different morphology having superior surface properties are getting wide importance in photocatalysis research. Despite having sodium (Na) contents and its high temperature synthesis (that generally deteriorate the photoreactivity), these Na-titanates often exhibit better photoactivity than P25-TiO{sub 2} catalyst. Hence, this work demonstrated the influence of crystal structure, BET surface area, surface charge, zeta potential (ζ) and metal loading on the photocatalytic activity of as-prepared sodium titanate nanotube (TNT) and titania nanorod (TNR). Straw like hollow orthorhombic-TNT (Na{sub 2}Ti{sub 2}O{sub 5}·H{sub 2}O) particles (W = 9–12 nm and L = 82–115 nm) and rice like pure anatase-TNR particles (W = 8–13 nm and L = 81–134 nm) are obtained by the hydrothermal treatment of P25-TiO{sub 2} with NaOH, which in fact, altered the net surface charge of TNT and TNR particles. The observed ζ = −2.82 (P25-TiO{sub 2}), −13.5 (TNT) and −22.5 mV (TNR) are significantly altered by the Ag and Cu deposition. It has been found here that TNT displayed best photocatalytic activity for the imidacloprid insecticide (C{sub 9}H{sub 10}ClN{sub 5}O{sub 2}) degradation to CO{sub 2} formation under UV irradiation because of its largest surface area 176 m{sup 2} g{sup −1} among the catalysts studied.

  8. 77 FR 72975 - Zeta Cypermethrin; Pesticide Tolerances

    Science.gov (United States)

    2012-12-07

    ... for quantifying risks, there is no increase in hazard with increasing dosing duration. Therefore, the... exposure models in the dietary exposure analysis and risk assessment for zeta-cypermethrin in drinking... the dietary exposure model. For acute dietary risk assessment, the water concentration value of 3.77...

  9. Probing the interaction of human serum albumin with vitamin B2 (riboflavin) and L-Arginine (L-Arg) using multi-spectroscopic, molecular modeling and zeta potential techniques

    Energy Technology Data Exchange (ETDEWEB)

    Memarpoor-Yazdi, Mina [Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of); Mahaki, Hanie, E-mail: hanieh.mahaki@gmail.com [Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of)

    2013-04-15

    This study was designed to examine the interaction of Riboflavin (RB) and L-Arginine (L-Arg) with human serum albumin (HSA) using different spectroscopic, zeta potential and molecular modeling techniques under imitated physiological conditions. The resonance light scattering (RLS) method determined the critical aggregation concentration of RB on HSA in the presence and absence of L-Arg which confirmed the zeta potential results. The binding constants (K{sub a}) of HSA–RB were 2.5×10{sup 4} and 9.7×10{sup 3} M{sup −1}, respectively in binary and ternary system at the excitation wavelength of 280 nm, also were 7.5×10{sup 3} and 7.3×10{sup 3}, respectively in binary and ternary system at the excitation wavelength of 295 nm. Fluorescence spectroscopy demonstrated that in the presence of L-Arg, the binding constant of HSA–RB was increased. Static quenching was confirmed to results in the fluorescence quenching and FRET. The binding distances between HSA and RB in two- and three-component systems were estimated by the Forster theory which revealed that nonradiative energy transfer from HSA to RB occurred with a high probability. The effect of RB on the conformation of HSA was analyzed using synchronous fluorescence spectroscopy and circular dichroism (CD) in both systems. Docking studies demonstrated a reduction in the binding affinity between RB and HSA in the presence of L-Arg. -- Highlights: ► We studied the interaction of riboflavin with HSA in presence and absence of L-Arg. ► Molecular modeling and zeta-potential used to describe competitive interaction. ► We compared the binding mechanism of riboflavin (RB) to HSA in both systems. ► We determined critical aggregation concentration of RB on HSA in both systems. ► The binding site of RB on HSA in both systems has been determined.

  10. Probing the interaction of human serum albumin with vitamin B2 (riboflavin) and L-Arginine (L-Arg) using multi-spectroscopic, molecular modeling and zeta potential techniques

    International Nuclear Information System (INIS)

    Memarpoor-Yazdi, Mina; Mahaki, Hanie

    2013-01-01

    This study was designed to examine the interaction of Riboflavin (RB) and L-Arginine (L-Arg) with human serum albumin (HSA) using different spectroscopic, zeta potential and molecular modeling techniques under imitated physiological conditions. The resonance light scattering (RLS) method determined the critical aggregation concentration of RB on HSA in the presence and absence of L-Arg which confirmed the zeta potential results. The binding constants (K a ) of HSA–RB were 2.5×10 4 and 9.7×10 3 M −1 , respectively in binary and ternary system at the excitation wavelength of 280 nm, also were 7.5×10 3 and 7.3×10 3 , respectively in binary and ternary system at the excitation wavelength of 295 nm. Fluorescence spectroscopy demonstrated that in the presence of L-Arg, the binding constant of HSA–RB was increased. Static quenching was confirmed to results in the fluorescence quenching and FRET. The binding distances between HSA and RB in two- and three-component systems were estimated by the Forster theory which revealed that nonradiative energy transfer from HSA to RB occurred with a high probability. The effect of RB on the conformation of HSA was analyzed using synchronous fluorescence spectroscopy and circular dichroism (CD) in both systems. Docking studies demonstrated a reduction in the binding affinity between RB and HSA in the presence of L-Arg. -- Highlights: ► We studied the interaction of riboflavin with HSA in presence and absence of L-Arg. ► Molecular modeling and zeta-potential used to describe competitive interaction. ► We compared the binding mechanism of riboflavin (RB) to HSA in both systems. ► We determined critical aggregation concentration of RB on HSA in both systems. ► The binding site of RB on HSA in both systems has been determined

  11. In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites.

    Science.gov (United States)

    Sommerfeld, Mark R; Metzger, Sabine; Stosik, Magdalene; Tennagels, Norbert; Eckel, Jürgen

    2004-05-18

    Protein kinase C-zeta (PKC-zeta) participates both in downstream insulin signaling and in the negative feedback control of insulin action. Here we used an in vitro approach to identify PKC-zeta phosphorylation sites within insulin receptor substrate 1 (IRS-1) and to characterize the functional implications. A recombinant IRS-1 fragment (rIRS-1(449)(-)(664)) containing major tyrosine motifs for interaction with phosphatidylinositol (PI) 3-kinase strongly associated to the p85alpha subunit of PI 3-kinase after Tyr phosphorylation by the insulin receptor. Phosphorylation of rIRS-1(449)(-)(664) by PKC-zeta induced a prominent inhibition of this process with a mixture of classical PKC isoforms being less effective. Both PKC-zeta and the classical isoforms phosphorylated rIRS-1(449)(-)(664) on Ser(612). However, modification of this residue did not reduce the affinity of p85alpha binding to pTyr-containing peptides (amino acids 605-615 of rat IRS-1), as determined by surface plasmon resonance. rIRS-1(449)(-)(664) was then phosphorylated by PKC-zeta using [(32)P]ATP and subjected to tryptic phosphopeptide mapping based on two-dimensional HPLC coupled to mass spectrometry. Ser(498) and Ser(570) were identified as novel phosphoserine sites targeted by PKC-zeta. Both sites were additionally confirmed by phosphopeptide mapping of the corresponding Ser --> Ala mutants of rIRS-1(449)(-)(664). Ser(570) was specifically targeted by PKC-zeta, as shown by immunoblotting with a phosphospecific antiserum against Ser(570) of IRS-1. Binding of p85alpha to the S570A mutant was less susceptible to inhibition by PKC-zeta, when compared to the S612A mutant. In conclusion, our in vitro data demonstrate a strong inhibitory action of PKC-zeta at the level of IRS-1/PI 3-kinase interaction involving multiple serine phosphorylation sites. Whereas Ser(612) appears not to participate in the negative control of insulin signaling, Ser(570) may at least partly contribute to this process.

  12. Relativistic double-zeta, triple-zeta, and quadruple-zeta basis sets for the lanthanides La–Lu

    NARCIS (Netherlands)

    Dyall, K.G.; Gomes, A.S.P.; Visscher, L.

    2010-01-01

    Relativistic basis sets of double-zeta, triple-zeta, and quadruple-zeta quality have been optimized for the lanthanide elements La-Lu. The basis sets include SCF exponents for the occupied spinors and for the 6p shell, exponents of correlating functions for the valence shells (4f, 5d and 6s) and the

  13. Bernoulli numbers and zeta functions

    CERN Document Server

    Arakawa, Tsuneo; Kaneko, Masanobu

    2014-01-01

    Two major subjects are treated in this book. The main one is the theory of Bernoulli numbers and the other is the theory of zeta functions. Historically, Bernoulli numbers were introduced to give formulas for the sums of powers of consecutive integers. The real reason that they are indispensable for number theory, however, lies in the fact that special values of the Riemann zeta function can be written by using Bernoulli numbers. This leads to more advanced topics, a number of which are treated in this book: Historical remarks on Bernoulli numbers and the formula for the sum of powers of consecutive integers; a formula for Bernoulli numbers by Stirling numbers; the Clausen–von Staudt theorem on the denominators of Bernoulli numbers; Kummer's congruence between Bernoulli numbers and a related theory of p-adic measures; the Euler–Maclaurin summation formula; the functional equation of the Riemann zeta function and the Dirichlet L functions, and their special values at suitable integers; various formulas of ...

  14. Lectures on zeta functions over finite fields

    OpenAIRE

    Wan, Daqing

    2007-01-01

    These are the notes from the summer school in G\\"ottingen sponsored by NATO Advanced Study Institute on Higher-Dimensional Geometry over Finite Fields that took place in 2007. The aim was to give a short introduction on zeta functions over finite fields, focusing on moment zeta functions and zeta functions of affine toric hypersurfaces.

  15. Activation-induced proteolysis of cytoplasmic domain of zeta in T cell receptors and Fc receptors.

    Science.gov (United States)

    Taupin, J L; Anderson, P

    1994-12-01

    The CD3-T cell receptor (TCR) complex on T cells and the Fc gamma receptor type III (Fc gamma RIII)-zeta-gamma complex on natural killer cells are functionally analogous activation receptors that associate with a family of disulfide-linked dimers composed of the related subunits zeta and gamma. Immunochemical analysis of receptor complexes separated on two-dimensional diagonal gels allowed the identification of a previously uncharacterized zeta-p14 heterodimer. zeta-p14 is a component of both CD3-TCR and Fc gamma RIII-zeta-gamma. Peptide mapping analysis shows that p14 is structurally related to zeta, suggesting that it is either: (i) derived from zeta proteolytically or (ii) the product of an alternatively spliced mRNA. The observation that COS cells transformed with a cDNA encoding zeta express zeta-p14 supports the former possibility. The expression of CD3-TCR complexes including zeta-p14 increases following activation with phorbol 12-myristate 13-acetate or concanavalin A, suggesting that proteolysis of zeta may contribute to receptor modulation or desensitization.

  16. Multifractal and higher-dimensional zeta functions

    International Nuclear Information System (INIS)

    Véhel, Jacques Lévy; Mendivil, Franklin

    2011-01-01

    In this paper, we generalize the zeta function for a fractal string (as in Lapidus and Frankenhuijsen 2006 Fractal Geometry, Complex Dimensions and Zeta Functions: Geometry and Spectra of Fractal Strings (New York: Springer)) in several directions. We first modify the zeta function to be associated with a sequence of covers instead of the usual definition involving gap lengths. This modified zeta function allows us to define both a multifractal zeta function and a zeta function for higher-dimensional fractal sets. In the multifractal case, the critical exponents of the zeta function ζ(q, s) yield the usual multifractal spectrum of the measure. The presence of complex poles for ζ(q, s) indicates oscillations in the continuous partition function of the measure, and thus gives more refined information about the multifractal spectrum of a measure. In the case of a self-similar set in R n , the modified zeta function yields asymptotic information about both the 'box' counting function of the set and the n-dimensional volume of the ε-dilation of the set

  17. Microencapsulation of β-Carotene Based on Casein/Guar Gum Blend Using Zeta Potential-Yield Stress Phenomenon: an Approach to Enhance Photo-stability and Retention of Functionality.

    Science.gov (United States)

    Thakur, Deepika; Jain, Ashay; Ghoshal, Gargi; Shivhare, U S; Katare, O P

    2017-07-01

    β-Carotene, abundant majorly in carrot, pink guava yams, spinach, kale, sweet potato, and palm oil, is an important nutrient for human health due to its scavenging action upon reactive free radicals wherever produced in the body. Inclusion of liposoluble β-carotene in foods and food ingredients is a challenging aspect due to its labile nature and low absorption from natural sources. This fact has led to the application of encapsulation of β-carotene to improve stability and bioavailability. The present work was aimed to fabricate microcapsules (MCs) of β-carotene oily dispersion using the complex coacervation technique with casein (CA) and guar gum (GG) blend. The ratio of CA:GG was found to be 1:0.5 (w/v) when optimized on the basis of zeta potential-yield stress phenomenon. These possessed a higher percentage yield (71.34 ± 0.55%), lower particle size (176.47 ± 4.65 μm), higher encapsulation efficiency (65.95 ± 5.33%), and in general, a uniform surface morphology was observed with particles showing optimized release behavior. Prepared MCs manifested effective and controlled release (up to 98%) following zero-order kinetics which was adequately explained by the Korseymer-Peppas model. The stability of the freeze-dried MCs was established in simulated gastrointestinal fluids (SGF, SIF) for 8 h. Antioxidant activity of the MCs was studied and revealed the retention of the functional architecture of β-carotene in freeze-dried MCs. Minimal photolytic degradation upon encapsulation of β-carotene addressed the challenge regarding photo-stability of β-carotene as confirmed via mass spectroscopy.

  18. Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO.

    Directory of Open Access Journals (Sweden)

    Marcos Rodrigo Alborghetti

    Full Text Available Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The human protein FEZ1 (fasciculation and elongation protein zeta 1 / UNC-76, in C. elegans, SCOCO (short coiled-coil protein / UNC-69 and kinesins (e.g. kinesin heavy chain / UNC116 are involved in these processes. Exploiting the feature of FEZ1 protein as a bivalent adapter of transport mediated by kinesins and FEZ1 protein interaction with SCOCO (proteins involved in the same path of axonal growth, we investigated the structural aspects of intermolecular interactions involved in this complex formation by NMR (Nuclear Magnetic Resonance, cross-linking coupled with mass spectrometry (MS, SAXS (Small Angle X-ray Scattering and molecular modelling. The topology of homodimerization was accessed through NMR (Nuclear Magnetic Resonance studies of the region involved in this process, corresponding to FEZ1 (92-194. Through studies involving the protein in its monomeric configuration (reduced and dimeric state, we propose that homodimerization occurs with FEZ1 chains oriented in an anti-parallel topology. We demonstrate that the interaction interface of FEZ1 and SCOCO defined by MS and computational modelling is in accordance with that previously demonstrated for UNC-76 and UNC-69. SAXS and literature data support a heterotetrameric complex model. These data provide details about the interaction interfaces probably involved in the transport machinery assembly and open perspectives to understand and interfere in this assembly and its involvement in neuronal differentiation and axon outgrowth.

  19. Status of the zeta(8.3)

    International Nuclear Information System (INIS)

    Lowe, S.T.

    1985-05-01

    Results are presented from 22.1 pb -1 of UPSILON(1S) data, taken with the Crystal Ball detector at DORIS. These data were taken to further explore the zeta(8.3) signal originally seen in 10.4 pb -1 of UPSILON(1S) data. No evidence for the zeta is observed in this new sample. Data quality checks and possible explanations are discussed

  20. Heat kernels and zeta functions on fractals

    International Nuclear Information System (INIS)

    Dunne, Gerald V

    2012-01-01

    On fractals, spectral functions such as heat kernels and zeta functions exhibit novel features, very different from their behaviour on regular smooth manifolds, and these can have important physical consequences for both classical and quantum physics in systems having fractal properties. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical in honour of Stuart Dowker's 75th birthday devoted to ‘Applications of zeta functions and other spectral functions in mathematics and physics’. (paper)

  1. Corrosion potential analysis system

    Science.gov (United States)

    Kiefer, Karl F.

    1998-03-01

    Many cities in the northeastern U.S. transport electrical power from place to place via underground cables, which utilize voltages from 68 kv to 348 kv. These cables are placed in seamless steel pipe to protect the conductors. These buried pipe-type-cables (PTCs) are carefully designed and constantly pressurized with transformer oil to prevent any possible contamination. A protective coating placed on the outside diameter of the pipe during manufacture protects the steel pipe from the soil environment. Notwithstanding the protection mechanisms available, the pipes remain vulnerable to electrochemical corrosion processes. If undetected, corrosion can cause the pipes to leak transformer oil into the environment. These leaks can assume serious proportions due to the constant pressure on the inside of the pipe. A need exists for a detection system that can dynamically monitor the corrosive potential on the length of the pipe and dynamically adjust cathodic protection to counter local and global changes in the cathodic environment surrounding the pipes. The northeastern United States contains approximately 1000 miles of this pipe. This milage is critical to the transportation and distribution of power. So critical, that each of the pipe runs has a redundant double running parallel to it. Invocon, Inc. proposed and tested a technically unique and cost effective solution to detect critical corrosion potential and to communicate that information to a central data collection and analysis location. Invocon's solution utilizes the steel of the casing pipe as a communication medium. Each data gathering station on the pipe can act as a relay for information gathered elsewhere on the pipe. These stations must have 'smart' network configuration algorithms that constantly test various communication paths and determine the best and most power efficient route through which information should flow. Each network station also performs data acquisition and analysis tasks that ultimately

  2. Lectures on the Riemann zeta function

    CERN Document Server

    Iwaniec, H

    2014-01-01

    The Riemann zeta function was introduced by L. Euler (1737) in connection with questions about the distribution of prime numbers. Later, B. Riemann (1859) derived deeper results about the prime numbers by considering the zeta function in the complex variable. The famous Riemann Hypothesis, asserting that all of the non-trivial zeros of zeta are on a critical line in the complex plane, is one of the most important unsolved problems in modern mathematics. The present book consists of two parts. The first part covers classical material about the zeros of the Riemann zeta function with applications to the distribution of prime numbers, including those made by Riemann himself, F. Carlson, and Hardy-Littlewood. The second part gives a complete presentation of Levinson's method for zeros on the critical line, which allows one to prove, in particular, that more than one-third of non-trivial zeros of zeta are on the critical line. This approach and some results concerning integrals of Dirichlet polynomials are new. Th...

  3. Zeta function of self-adjoint operators on surfaces of revolution

    International Nuclear Information System (INIS)

    Lu, Tianshi; Jeffres, Thalia; Kirsten, Klaus

    2015-01-01

    In this article we analyze the zeta function for the Laplace operator on a surface of revolution. A variety of boundary conditions, separated and unseparated, are considered. Formulas for several residues and values of the zeta function as well as for the determinant of the Laplacian are obtained. The analysis is based upon contour integration techniques in combination with a WKB analysis of solutions of related initial value problems. (paper)

  4. Zeta function methods and quantum fluctuations

    International Nuclear Information System (INIS)

    Elizalde, Emilio

    2008-01-01

    A review of some recent advances in zeta function techniques is given, in problems of pure mathematical nature but also as applied to the computation of quantum vacuum fluctuations in different field theories, and specially with a view to cosmological applications

  5. New inequalities for the Hurwitz zeta function

    Indian Academy of Sciences (India)

    We establish various new inequalities for the Hurwitz zeta function. Our results generalize some known results ... mention here two of them: The first is the evaluation by Kolbig [10] of integrals of the form. Rm(μ, υ) = ∫ ∞. 0 e. −μttυ−1 log m t dt,.

  6. Bernoulli Polynomials, Fourier Series and Zeta Numbers

    DEFF Research Database (Denmark)

    Scheufens, Ernst E

    2013-01-01

    Fourier series for Bernoulli polynomials are used to obtain information about values of the Riemann zeta function for integer arguments greater than one. If the argument is even we recover the well-known exact values, if the argument is odd we find integral representations and rapidly convergent...

  7. Euler Polynomials, Fourier Series and Zeta Numbers

    DEFF Research Database (Denmark)

    Scheufens, Ernst E

    2012-01-01

    Fourier series for Euler polynomials is used to obtain information about values of the Riemann zeta function for integer arguments greater than one. If the argument is even we recover the well-known exact values, if the argument is odd we find integral representations and rapidly convergent series....

  8. Exploring the Riemann zeta function 190 years from Riemann's birth

    CERN Document Server

    Nikeghbali, Ashkan; Rassias, Michael

    2017-01-01

    This book is concerned with the Riemann Zeta Function, its generalizations, and various applications to several scientific disciplines, including Analytic Number Theory, Harmonic Analysis, Complex Analysis and Probability Theory. Eminent experts in the field illustrate both old and new results towards the solution of long-standing problems and include key historical remarks. Offering a unified, self-contained treatment of broad and deep areas of research, this book will be an excellent tool for researchers and graduate students working in Mathematics, Mathematical Physics, Engineering and Cryptography.

  9. Fractal diffusion coefficient from dynamical zeta functions

    Energy Technology Data Exchange (ETDEWEB)

    Cristadoro, Giampaolo [Max Planck Institute for the Physics of Complex Systems, Noethnitzer Str. 38, D 01187 Dresden (Germany)

    2006-03-10

    Dynamical zeta functions provide a powerful method to analyse low-dimensional dynamical systems when the underlying symbolic dynamics is under control. On the other hand, even simple one-dimensional maps can show an intricate structure of the grammar rules that may lead to a non-smooth dependence of global observables on parameters changes. A paradigmatic example is the fractal diffusion coefficient arising in a simple piecewise linear one-dimensional map of the real line. Using the Baladi-Ruelle generalization of the Milnor-Thurnston kneading determinant, we provide the exact dynamical zeta function for such a map and compute the diffusion coefficient from its smallest zero. (letter to the editor)

  10. Fractal diffusion coefficient from dynamical zeta functions

    International Nuclear Information System (INIS)

    Cristadoro, Giampaolo

    2006-01-01

    Dynamical zeta functions provide a powerful method to analyse low-dimensional dynamical systems when the underlying symbolic dynamics is under control. On the other hand, even simple one-dimensional maps can show an intricate structure of the grammar rules that may lead to a non-smooth dependence of global observables on parameters changes. A paradigmatic example is the fractal diffusion coefficient arising in a simple piecewise linear one-dimensional map of the real line. Using the Baladi-Ruelle generalization of the Milnor-Thurnston kneading determinant, we provide the exact dynamical zeta function for such a map and compute the diffusion coefficient from its smallest zero. (letter to the editor)

  11. The design and performance of ZETA

    Energy Technology Data Exchange (ETDEWEB)

    Butt, E P; Carruthers, R; Mitchell, J T.D.; Pease, R S; Thonemann, P C [U.K. Atomic Energy Authority, AERE Harwell (United Kingdom); Bird, M A; Blears, J; Hartill, E R [Metropolitan Vickers Electrical Co. Ltd., Trafiord Park, Manchester 17 (United Kingdom)

    1958-07-01

    ZETA is an experimental apparatus for studying the pinched ring discharge as a possible method of producing controlled thermonuclear power. The principle of this method is that the self-magnetic field of the discharge current isolates the plasma from the walls of the discharge tube. The present paper reports the principal mechanical and electrical parameters, the performance as an electrical circuit, and our present knowledge of the physical characteristics of the plasma.

  12. Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability.

    Science.gov (United States)

    Kashir, Junaid; Jones, Celine; Mounce, Ginny; Ramadan, Walaa M; Lemmon, Bernadette; Heindryckx, Bjorn; de Sutter, Petra; Parrington, John; Turner, Karen; Child, Tim; McVeigh, Enda; Coward, Kevin

    2013-01-01

    To examine whether similar levels of phospholipase C zeta (PLC-ζ) protein are present in sperm from men whose ejaculates resulted in normal oocyte activation, and to examine whether a predominant pattern of PLC-ζ localization is linked to normal oocyte activation ability. Laboratory study. University laboratory. Control subjects (men with proven oocyte activation capacity; n = 16) and men whose sperm resulted in recurrent intracytoplasmic sperm injection failure (oocyte activation deficient [OAD]; n = 5). Quantitative immunofluorescent analysis of PLC-ζ protein in human sperm. Total levels of PLC-ζ fluorescence, proportions of sperm exhibiting PLC-ζ immunoreactivity, and proportions of PLC-ζ localization patterns in sperm from control and OAD men. Sperm from control subjects presented a significantly higher proportion of sperm exhibiting PLC-ζ immunofluorescence compared with infertile men diagnosed with OAD (82.6% and 27.4%, respectively). Total levels of PLC-ζ in sperm from individual control and OAD patients exhibited significant variance, with sperm from 10 out of 16 (62.5%) exhibiting levels similar to OAD samples. Predominant PLC-ζ localization patterns varied between control and OAD samples with no predictable or consistent pattern. The results indicate that sperm from control men exhibited significant variance in total levels of PLC-ζ protein, as well as significant variance in the predominant localization pattern. Such variance may hinder the diagnostic application of quantitative PLC-ζ immunofluorescent analysis. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  13. Integrated module inverter using a zeta DC-DC converter with feedforward MPPT (Maximum Power Point Tracking) control; Inversor modulo integrado utilizando um conversor CC-CC zeta com controle MPPT feedforward

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, Henrique Fioravanti Miguel

    2009-08-15

    This work presents the study and development of a processing power system that could be used in the connection of renewable energy sources to commercial power grid. The system consists of a ZETA converter associated with a bridge inverter operating at low frequency. The Zeta converter, operating in discontinuous conduction mode (DCM), plays the main role in this arrangement, producing a rectified sinusoidal current waveform synchronized with the electric grid. The function of the full-bridge inverter, connected in cascade with the Zeta converter, is to reverse every 180 deg the current generated by the Zeta converter. Initially it presents the analysis of the Zeta converter operating in DCM, as well as a design criterion. Following by the control strategy and the experimental results for the proposed system are presented and discussed. (author)

  14. Ten physical applications of spectral zeta functions

    CERN Document Server

    Elizalde, Emilio

    1995-01-01

    Zeta-function regularization is a powerful method in perturbation theory. This book is meant as a guide for the student of this subject. Everything is explained in detail, in particular the mathematical difficulties and tricky points, and several applications are given to show how the procedure works in practice (e.g. Casimir effect, gravity and string theory, high-temperature phase transition, topological symmetry breaking). The formulas some of which are new can be used for accurate numerical calculations. The book is to be considered as a basic introduction and a collection of exercises for those who want to apply this regularization procedure in practice.

  15. Ten physical applications of spectral zeta functions

    CERN Document Server

    Elizalde, Emilio

    2012-01-01

    Zeta-function regularization is a powerful method in perturbation theory, and this book is a comprehensive guide for the student of this subject. Everything is explained in detail, in particular the mathematical difficulties and tricky points, and several applications are given to show how the procedure works in practice, for example in the Casimir effect, gravity and string theory, high-temperature phase transition, topological symmetry breaking, and non-commutative spacetime. The formulae, some of which are new, can be directly applied in creating physically meaningful, accurate numerical calculations. The book acts both as a basic introduction and a collection of exercises for those who want to apply this regularization procedure in practice. Thoroughly revised, updated and expanded, this new edition includes novel, explicit formulas on the general quadratic, the Chowla-Selberg series case, an interplay with the Hadamard calculus, and also features a fresh chapter on recent cosmological applications, inclu...

  16. Selberg zeta functions and transfer operators an experimental approach to singular perturbations

    CERN Document Server

    Fraczek, Markus Szymon

    2017-01-01

    This book presents a method for evaluating Selberg zeta functions via transfer operators for the full modular group and its congruence subgroups with characters. Studying zeros of Selberg zeta functions for character deformations allows us to access the discrete spectra and resonances of hyperbolic Laplacians under both singular and non-singular perturbations. Areas in which the theory has not yet been sufficiently developed, such as the spectral theory of transfer operators or the singular perturbation theory of hyperbolic Laplacians, will profit from the numerical experiments discussed in this book. Detailed descriptions of numerical approaches to the spectra and eigenfunctions of transfer operators and to computations of Selberg zeta functions will be of value to researchers active in analysis, while those researchers focusing more on numerical aspects will benefit from discussions of the analytic theory, in particular those concerning the transfer operator method and the spectral theory of hyperbolic spac...

  17. The multiple zeta value data mine

    Energy Technology Data Exchange (ETDEWEB)

    Buemlein, J. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Broadhurst, D.J. [Open Univ., Milton Keynes (United Kingdom). Physics and Astronomy Dept.; Vermaseren, J.A.M. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); NIKHEF, Amsterdam (Netherlands)

    2009-07-15

    We provide a data mine of proven results for multiple zeta values (MZVs) of the form {zeta}(s{sub 1},s{sub 2},..,s{sub k}) = sum {sup {infinity}}{sub n{sub 1}}{sub >n{sub 2}}{sub >...>n{sub k}}{sub >0} {l_brace}1/(n{sub 1}{sup s{sub 1}}..n{sub k}{sup s{sub k}}){r_brace} with weight w = sum {sup K}{sub i=1}s{sub i} and depth k and for Euler sums of the form sum {sup {infinity}}{sub n{sub 1}}{sub >n{sub 2}}{sub >...>n{sub k}}{sub >0} {l_brace}({epsilon}{sub 1}{sup n{sub 1}}..{epsilon}{sub 1}{sup n{sub k}})/(n{sub 1}{sup s{sub 1}}..n{sub k}{sup s{sub k}}){r_brace} with signs {epsilon}{sub i} = {+-} 1. Notably, we achieve explicit proven reductions of all MZVs with weights w{<=}22, and all Euler sums with weights w{<=}12, to bases whose dimensions, bigraded by weight and depth, have sizes in precise agreement with the Broadhurst. Kreimer and Broadhurst conjectures. Moreover, we lend further support to these conjectures by studying even greater weights (w{<=}30), using modular arithmetic. To obtain these results we derive a new type of relation for Euler sums, the Generalized Doubling Relations. We elucidate the ''pushdown'' mechanism, whereby the ornate enumeration of primitive MZVs, by weight and depth, is reconciled with the far simpler enumeration of primitive Euler sums. There is some evidence that this pushdown mechanism finds its origin in doubling relations. We hope that our data mine, obtained by exploiting the unique power of the computer algebra language FORM, will enable the study of many more such consequences of the double-shuffle algebra of MZVs, and their Euler cousins, which are already the subject of keen interest, to practitioners of quantum field theory, and to mathematicians alike. (orig.)

  18. The multiple zeta value data mine

    International Nuclear Information System (INIS)

    Buemlein, J.; Broadhurst, D.J.

    2009-07-01

    We provide a data mine of proven results for multiple zeta values (MZVs) of the form ζ(s 1 ,s 2 ,..,s k ) = sum ∞ n 1 >n 2 >...>n k >0 {1/(n 1 s 1 ..n k s k )} with weight w = sum K i=1 s i and depth k and for Euler sums of the form sum ∞ n 1 >n 2 >...>n k >0 {(ε 1 n 1 ..ε 1 n k )/(n 1 s 1 ..n k s k )} with signs ε i = ± 1. Notably, we achieve explicit proven reductions of all MZVs with weights w≤22, and all Euler sums with weights w≤12, to bases whose dimensions, bigraded by weight and depth, have sizes in precise agreement with the Broadhurst. Kreimer and Broadhurst conjectures. Moreover, we lend further support to these conjectures by studying even greater weights (w≤30), using modular arithmetic. To obtain these results we derive a new type of relation for Euler sums, the Generalized Doubling Relations. We elucidate the ''pushdown'' mechanism, whereby the ornate enumeration of primitive MZVs, by weight and depth, is reconciled with the far simpler enumeration of primitive Euler sums. There is some evidence that this pushdown mechanism finds its origin in doubling relations. We hope that our data mine, obtained by exploiting the unique power of the computer algebra language FORM, will enable the study of many more such consequences of the double-shuffle algebra of MZVs, and their Euler cousins, which are already the subject of keen interest, to practitioners of quantum field theory, and to mathematicians alike. (orig.)

  19. Mayer Transfer Operator Approach to Selberg Zeta Function

    DEFF Research Database (Denmark)

    Momeni, Arash; Venkov, Alexei

    . In a special situation the dynamical zeta function is defined for a geodesic flow on a hyperbolic plane quotient by an arithmetic cofinite discrete group. More precisely, the flow is defined for the corresponding unit tangent bundle. It turns out that the Selberg zeta function for this group can be expressed...... in terms of a Fredholm determinant of a classical transfer operator of the flow. The transfer operator is defined in a certain space of holomorphic functions and its matrix representation in a natural basis is given in terms of the Riemann zeta function and the Euler gamma function....

  20. Involvement of proteasomal subunits zeta and iota in RNA degradation.

    Science.gov (United States)

    Petit, F; Jarrousse, A S; Dahlmann, B; Sobek, A; Hendil, K B; Buri, J; Briand, Y; Schmid, H P

    1997-01-01

    We have identified two distinct subunits of 20 S proteasomes that are associated with RNase activity. Proteasome subunits zeta and iota, eluted from two-dimensional Western blots, hydrolysed tobacco mosaic virus RNA, whereas none of the other subunits degraded this substrate under the same conditions. Additionally, proteasomes were dissociated by 6 M urea, and subunit zeta, containing the highest RNase activity, was isolated by anion-exchange chromatography and gel filtration. Purified subunit zeta migrated as a single spot on two-dimensional PAGE with a molecular mass of approx. 28 kDa. Addition of anti-(subunit zeta) antibodies led to the co-precipitation of this proteasome subunit and nuclease activity. This is the first evidence that proteasomal alpha-type subunits are associated with an enzymic activity, and our results provide further evidence that proteasomes may be involved in cellular RNA metabolism. PMID:9337855

  1. From Fourier Series to Rapidly Convergent Series for Zeta(3)

    DEFF Research Database (Denmark)

    Scheufens, Ernst E

    2011-01-01

    The article presents a mathematical study which investigates the exact values of the Riemann zeta (ζ) function. It states that exact values can be determined from Fourier series for periodic versions of even power functions. It notes that using power series for logarithmic functions on this such ......The article presents a mathematical study which investigates the exact values of the Riemann zeta (ζ) function. It states that exact values can be determined from Fourier series for periodic versions of even power functions. It notes that using power series for logarithmic functions...

  2. Crossing the entropy barrier of dynamical zeta functions

    International Nuclear Information System (INIS)

    Aurich, R.; Bolte, J.; Matthies, C.; Sieber, M.; Steiner, F.

    1992-01-01

    Dynamical zeta functions are an important tool to quantize chaotic dynamical systems. The basic quantization rules require the computation of the zeta functions on the real energy axis, where the Euler product representations running over the classical periodic orbits usually do not converge due to the existence of the so-called entropy barrier determined by the topological entropy of the classical system. We shown that the convergence properties of the dynamical zeta functions rewritten as Dirichlet series are governed not only by the well-known topological and metric entropy, but depend crucially on subtle statistical properties of the Maslow indices and of the multiplicities of the periodic orbits that are measured by a new parameter for which we introduce the notion of a third entropy. If and only if the third entropy is nonvanishing, one can cross the entropy barrier; if it exceeds a certain value, one can even compute the zeta function in the physical region by means of a convergent Dirichlet series. A simple statistical model is presented which allows to compute the third entropy. Four examples of chaotic systems are studied in detail to test the model numerically. (orig.)

  3. Dynamical zeta functions for piecewise monotone maps of the interval

    CERN Document Server

    Ruelle, David

    2004-01-01

    Consider a space M, a map f:M\\to M, and a function g:M \\to {\\mathbb C}. The formal power series \\zeta (z) = \\exp \\sum ^\\infty _{m=1} \\frac {z^m}{m} \\sum _{x \\in \\mathrm {Fix}\\,f^m} \\prod ^{m-1}_{k=0} g (f^kx) yields an example of a dynamical zeta function. Such functions have unexpected analytic properties and interesting relations to the theory of dynamical systems, statistical mechanics, and the spectral theory of certain operators (transfer operators). The first part of this monograph presents a general introduction to this subject. The second part is a detailed study of the zeta functions associated with piecewise monotone maps of the interval [0,1]. In particular, Ruelle gives a proof of a generalized form of the Baladi-Keller theorem relating the poles of \\zeta (z) and the eigenvalues of the transfer operator. He also proves a theorem expressing the largest eigenvalue of the transfer operator in terms of the ergodic properties of (M,f,g).

  4. On calculation of zeta function of integral matrix

    Czech Academy of Sciences Publication Activity Database

    Janáček, Jiří

    2009-01-01

    Roč. 134, č. 1 (2009), s. 49-58 ISSN 0862-7959 R&D Projects: GA AV ČR(CZ) IAA100110502 Institutional research plan: CEZ:AV0Z50110509 Keywords : Epstein zeta function * integral lattice * Riemann theta function Subject RIV: BA - General Mathematics

  5. Crossing the entropy barrier of dynamical zeta functions

    Energy Technology Data Exchange (ETDEWEB)

    Aurich, R.; Bolte, J.; Matthies, C.; Sieber, M.; Steiner, F. (Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik)

    1992-01-01

    Dynamical zeta functions are an important tool to quantize chaotic dynamical systems. The basic quantization rules require the computation of the zeta functions on the real energy axis, where the Euler product representations running over the classical periodic orbits usually do not converge due to the existence of the so-called entropy barrier determined by the topological entropy of the classical system. We shown that the convergence properties of the dynamical zeta functions rewritten as Dirichlet series are governed not only by the well-known topological and metric entropy, but depend crucially on subtle statistical properties of the Maslow indices and of the multiplicities of the periodic orbits that are measured by a new parameter for which we introduce the notion of a third entropy. If and only if the third entropy is nonvanishing, one can cross the entropy barrier; if it exceeds a certain value, one can even compute the zeta function in the physical region by means of a convergent Dirichlet series. A simple statistical model is presented which allows to compute the third entropy. Four examples of chaotic systems are studied in detail to test the model numerically. (orig.).

  6. Spectral zeta function and non-perturbative effects in ABJM Fermi-gas

    International Nuclear Information System (INIS)

    Hatsuda, Yasuyuki

    2015-03-01

    The exact partition function in ABJM theory on three-sphere can be regarded as a canonical partition function of a non-interacting Fermi-gas with an unconventional Hamiltonian. All the information on the partition function is encoded in the discrete spectrum of this Hamiltonian. We explain how (quantum mechanical) non-perturbative corrections in the Fermi-gas system appear from a spectral consideration. Basic tools in our analysis are a Mellin-Barnes type integral representation and a spectral zeta function. From a consistency with known results, we conjecture that the spectral zeta function in the ABJM Fermi-gas has an infinite number of ''non-perturbative'' poles, which are invisible in the semi-classical expansion of the Planck constant. We observe that these poles indeed appear after summing up perturbative corrections. As a consequence, the perturbative resummation of the spectral zeta function causes non-perturbative corrections to the grand canonical partition function. We also present another example associated with a spectral problem in topological string theory. A conjectured non-perturbative free energy on the resolved conifold is successfully reproduced in this framework.

  7. Lecture notes: string theory and zeta-function

    Energy Technology Data Exchange (ETDEWEB)

    Toppan, Francesco [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil). E-mail: toppan@cbpf.br

    2001-11-01

    These lecture notes are based on a revised and LaTexed version of the Master thesis defended at ISAS. The research part being omitted, they included a review of the bosonic closed string a la Polyakov and of the one-loop background field method of quantisation defined through the zeta-function. In an appendix some basic features of the Riemann zeta-function are also reviewed. The pedagogical aspects of the material here presented are particularly emphasized. These notes are used, together with the Scherk's article in Rev. Mod. Phys. and the first volume of the Polchinski book, for the mini-course on String Theory (16-hours of lectures) held at CBPF. In this course the Green-Schwarz-Witten two-volumes book is also used for consultative purposes. (author)

  8. Relating zeta functions of discrete and quantum graphs

    Science.gov (United States)

    Harrison, Jonathan; Weyand, Tracy

    2018-02-01

    We write the spectral zeta function of the Laplace operator on an equilateral metric graph in terms of the spectral zeta function of the normalized Laplace operator on the corresponding discrete graph. To do this, we apply a relation between the spectrum of the Laplacian on a discrete graph and that of the Laplacian on an equilateral metric graph. As a by-product, we determine how the multiplicity of eigenvalues of the quantum graph, that are also in the spectrum of the graph with Dirichlet conditions at the vertices, depends on the graph geometry. Finally we apply the result to calculate the vacuum energy and spectral determinant of a complete bipartite graph and compare our results with those for a star graph, a graph in which all vertices are connected to a central vertex by a single edge.

  9. Zeta functional equation on Jordan algebras of type II

    International Nuclear Information System (INIS)

    Kayoya, J.B.

    2003-10-01

    Using the Jordan algebras method, specially the properties of Peirce decomposition and the Frobenius transformation, we compute the coefficients of the zeta functional equation, in the case of Jordan algebras of Type II. As particular cases of our result, we can cite the case of V M (n, R) studied by Gelbart and Godement-Jacquet, and the case of V Herm(3, O s ) studied by Muro. Let us also mention, that recently, Bopp and Rubenthaler have obtained a more general result on the zeta functional equation by using methods based on the algebraic properties of regular graded algebras which are in one to one correspondence with simple Jordan algebras. The method used in this paper is a direct application of specific properties of Jordan algebras of Type H. (author)

  10. Potencial zeta de sulfatos de de bario y de estroncio

    OpenAIRE

    Delgado M., Edgar

    2010-01-01

    Por medio de la electroforesis se determinó las movilidades electroforéticas y los potenciales zeta del sulfato de bario a 25,0 °C como función de la fuerza iónica de NaCI, así como del Sulfato de estroncio en función de la fuerza iónica del cloruro de sodio y del pH. Se encontró que el amento de la fuerza iónica de NaCI causa un cambio del Potencial Zeta negativo del sulfato de estroncio a positivo con valor cero a aprox. 0,06 de fuerza iónica. El P.Z. del sulfato de estroncio es positivo...

  11. Multiple zeta values and application to the Lacunary recurrence formulas of Bernoulli numbers

    International Nuclear Information System (INIS)

    Chen, Y-H

    2008-01-01

    This paper obtains a recurrence related to multiple zeta function, which generalizes the Newton recurrence for multiple zeta values for period 1. Moreover, we obtain some new Lacunary recurrence formulas of Bernoulli numbers

  12. Evaluation of spectral zeta-functions with the renormalization group

    International Nuclear Information System (INIS)

    Boettcher, Stefan; Li, Shanshan

    2017-01-01

    We evaluate spectral zeta-functions of certain network Laplacians that can be treated exactly with the renormalization group. As specific examples we consider a class of Hanoi networks and those hierarchical networks obtained by the Migdal–Kadanoff bond moving scheme from regular lattices. As possible applications of these results we mention quantum search algorithms as well as synchronization, which we discuss in more detail. (paper)

  13. A zeta function approach to the semiclassical quantization of maps

    International Nuclear Information System (INIS)

    Smilansky, Uzi.

    1993-11-01

    The quantum analogue of an area preserving map on a compact phase space is a unitary (evolution) operator which can be represented by a matrix of dimension L∝ℎ -1 . The semiclassical theory for spectrum of the evolution operator will be reviewed with special emphasize on developing a dynamical zeta function approach, similar to the one introduced recently for a semiclassical quantization of hamiltonian systems. (author)

  14. Relationship between phospholipase C-zeta, semen parameters, and chromatin status.

    Science.gov (United States)

    Tavalaee, Marziyeh; Kiani-Esfahani, Abbas; Nasr-Esfahani, Mohammad H

    2017-08-01

    The need for additional tests to complement basic sperm analysis in clinics is well appreciated. In this regard, a number of tests such as sperm DNA integrity test as a tool in diagnosis and treatment of infertility are suggested. But recent studies have focused on main sperm factors involved in oocyte activation such as phospholipase C-zeta (PLCζ) that initiate intracellular Ca 2+ signaling and embryogenesis. Therefore, this study aimed to investigate the relationship between PLCζ, basic semen parameters, sperm DNA fragmentation (SDF), and protamine deficiency in men with normal (n=32) and abnormal (n=23) semen parameters. Unlike SDF and protamine deficiency, as negative factors related to fertility, the mean value of PLCζ as positive factor related to infertility was significantly lower in men with abnormal semen parameters compared to men with normal semen parameters. Significant correlations were also observed between sperm concentration, motility, and abnormal morphology with the percentage of PLCζ positive spermatozoa. In addition, logistic regression analysis revealed that sperm morphology is more predictive than sperm motility and concentration for PLCζ presence. In addition, a statistically significant negative relationship was observed between the percentage of PLCζ positive spermatozoa and SDF. These findings suggested during ICSI, selection of sperm based on morphology has a profound effect on its ability to induce oocyte activation based on the likelihood of PLCζ expression. Therefore, assessment of PLCζ as an index for fertilization potential of a semen sample in men with severe teratozoospermia may define individuals who are candidates for artificial oocyte activation (AOA) and may avoid failed fertilization post ICSI.

  15. Justification of the zeta-function renormalization in rigid string model

    International Nuclear Information System (INIS)

    Nesterenko, V.V.; Pirozhenko, I.G.

    1997-01-01

    A consistent procedure for regularization of divergences and for the subsequent renormalization of the string tension is proposed in the framework of the one-loop calculation of the interquark potential generated by the Polyakov-Kleinert string. In this way, a justification of the formal treatment of divergences by analytic continuation of the Riemann and Epstein-Hurwitz zeta-functions is given. A spectral representation for the renormalized string energy at zero temperature is derived, which enables one to find the Casimir energy in this string model at nonzero temperature very easy

  16. Functional equation for the Mordell-Tornheim multiple zeta-function

    OpenAIRE

    Okamoto, Takuya; Onozuka, Tomokazu

    2016-01-01

    We show a relation between the Mordell-Tornheim multiple zeta-function and the confluent hypergeometric function, and using it, we give the functional equation for the Mordell-Tornheim multiple zeta-function. In the double case, the functional equation includes the known functional equation for the Euler-Zagier double zeta-function.

  17. EMPLOYER BRAND AND ANALYSIS OF INDIVIDUAL POTENTIAL

    Directory of Open Access Journals (Sweden)

    Ljiljana Stošić Mihajlović

    2013-01-01

    Full Text Available As companies and individuals to live their best release? What should companies and individuals were the most successful? What job would bring the most satisfaction and opportunities for further development? What would be the fastest way led to the realization of corporate goals and their own? Answers to these questions can be obtained through analysis of employer brand and Analysis of individual potential (AIP. Employer brand analysis and analysis of individual potential is the process of identifying the strengths and potential of the company as well as a person. In this way, determining what it is that a company or person works best, how to motivate people and to the field of application of discovered talent. The main objective of this procedure is the development of an overall as well as personal and professional development of individuals in the direction of those activities and areas that will bring long-term satisfaction

  18. The semi-simple zeta function of quaternionic Shimura varieties

    CERN Document Server

    Reimann, Harry

    1997-01-01

    This monograph is concerned with the Shimura variety attached to a quaternion algebra over a totally real number field. For any place of good (or moderately bad) reduction, the corresponding (semi-simple) local zeta function is expressed in terms of (semi-simple) local L-functions attached to automorphic representations. In an appendix a conjecture of Langlands and Rapoport on the reduction of a Shimura variety in a very general case is restated in a slightly stronger form. The reader is expected to be familiar with the basic concepts of algebraic geometry, algebraic number theory and the theory of automorphic representation.

  19. The Riemann zeta-function theory and applications

    CERN Document Server

    Ivic, Aleksandar

    2003-01-01

    ""A thorough and easily accessible account.""-MathSciNet, Mathematical Reviews on the Web, American Mathematical Society. This extensive survey presents a comprehensive and coherent account of Riemann zeta-function theory and applications. Starting with elementary theory, it examines exponential integrals and exponential sums, the Voronoi summation formula, the approximate functional equation, the fourth power moment, the zero-free region, mean value estimates over short intervals, higher power moments, and omega results. Additional topics include zeros on the critical line, zero-density estim

  20. The Stokes phenomenon and the Lerch zeta function

    Directory of Open Access Journals (Sweden)

    R. B. Paris

    2016-05-01

    Full Text Available We examine the exponentially improved asymptotic expansion of the Lerch zeta function $L(\\lambda,a,s=\\sum_{n=0}^\\infty \\exp (2\\pi ni\\lambda/(n+a^s$ for large complex values of $a$, with $\\lambda$ and $s$ regarded as parameters. It is shown that an infinite number of subdominant exponential terms switch on across the Stokes lines $\\arg\\,a=\\pm\\fs\\pi$. In addition, it is found that the transition across the upper and lower imaginary $a$-axes is associated, in general, with unequal scales. Numerical calculations are presented to confirm the theoretical predictions.

  1. Fluctuations of quantum fields via zeta function regularization

    International Nuclear Information System (INIS)

    Cognola, Guido; Zerbini, Sergio; Elizalde, Emilio

    2002-01-01

    Explicit expressions for the expectation values and the variances of some observables, which are bilinear quantities in the quantum fields on a D-dimensional manifold, are derived making use of zeta function regularization. It is found that the variance, related to the second functional variation of the effective action, requires a further regularization and that the relative regularized variance turns out to be 2/N, where N is the number of the fields, thus being independent of the dimension D. Some illustrating examples are worked through. The issue of the stress tensor is also briefly addressed

  2. Introduction of an Elementary Method to Express $\\zeta(2n+1)$ in Terms of $\\zeta(2k)$ with $k\\geq 1$

    OpenAIRE

    Fujii, Kazuyuki; Suzuki, Tatsuo

    2008-01-01

    In this note we give the most elementary method (as far as we know) to express $\\zeta(2n+1)$ in terms of $\\{\\zeta(2k)|k\\geq 1\\}$. The method is based on only some elementary works by Leonhard Euler, so it is very instructive to non-experts or students.

  3. [Discourse analysis: research potentialities to gender violence].

    Science.gov (United States)

    de Azambuja, Mariana Porto Ruwer; Nogueira, Conceição

    2009-01-01

    In the last few years we see the growing use of the terms 'discourse' and 'discourses analysis' in academic and research contexts, frequently without a precise definition. This fact opens space for critics and mistakes. The aim of this paper is to show a brief contextualization of discursive studies, as well as tasks/steps to Discourse Analysis process by the Social Construcionism perspective. As examples we used fragments of an interview with a Family Doctor about gender violence. In the results we detach the potential of Discourse Analysis to deconstruct the existing discourses to subsequently (re)construction in the way to a more holistic view about gender violence problem.

  4. Potencial zeta de sulfatos de de bario y de estroncio

    Directory of Open Access Journals (Sweden)

    Edgar Delgado M.

    2010-06-01

    Full Text Available Por medio de la electroforesis se determinó las movilidades electroforéticas y los potenciales zeta del sulfato de bario a 25,0 °C como función de la fuerza iónica de NaCI, así como del Sulfato de estroncio en función de la fuerza iónica del cloruro de sodio y del pH. Se encontró que el amento de la fuerza iónica de NaCI causa un cambio del Potencial Zeta negativo del sulfato de estroncio a positivo con valor cero a aprox. 0,06 de fuerza iónica. El P.Z. del sulfato de estroncio es positivo a pH inferiores a aprox. 2,5 y negativo a pH superiores. El sulfato de bario presenta P.Z. negativas a fuerza iónicas de NaCI inferiores a aprox. 0.06 y PZ positivos a fuerzas iónicas mayores

  5. Can Eccentric Debris Disks Be Long-lived? A First Numerical Investigation and Application to Zeta(exp 2) Reticuli

    Science.gov (United States)

    Faramaz, V.; Beust, H.; Thebault, P.; Augereau, J.-C.; Bonsor, A.; delBurgo, C.; Ertel, S.; Marshall, J. P.; Milli, J.; Montesinos, B.; hide

    2014-01-01

    Context. Imaging of debris disks has found evidence for both eccentric and offset disks. One hypothesis is that they provide evidence for massive perturbers, for example, planets or binary companions, which sculpt the observed structures. One such disk was recently observed in the far-IR by the Herschel Space Observatory around Zeta2 Reticuli. In contrast with previously reported systems, the disk is significantly eccentric, and the system is several Gyr old. Aims. We aim to investigate the long-term evolution of eccentric structures in debris disks caused by a perturber on an eccentric orbit around the star. We hypothesise that the observed eccentric disk around Zeta2 Reticuli might be evidence of such a scenario. If so, we are able to constrain the mass and orbit of a potential perturber, either a giant planet or a binary companion. Methods. Analytical techniques were used to predict the effects of a perturber on a debris disk. Numerical N-body simulations were used to verify these results and further investigate the observable structures that may be produced by eccentric perturbers. The long-term evolution of the disk geometry was examined, with particular application to the Zeta2 Reticuli system. In addition, synthetic images of the disk were produced for direct comparison with Herschel observations. Results. We show that an eccentric companion can produce both the observed offsets and eccentric disks. These effects are not immediate, and we characterise the timescale required for the disk to develop to an eccentric state (and any spirals to vanish). For Zeta2 Reticuli, we derive limits on the mass and orbit of the companion required to produce the observations. Synthetic images show that the pattern observed around Zeta2 Reticuli can be produced by an eccentric disk seen close to edge-on, and allow us to bring additional constraints on the disk parameters of our model (disk flux and extent). Conclusions. We conclude that eccentric planets or stellar companions

  6. Consistent microscopic and phenomenological analysis of composite particle opticle potential

    International Nuclear Information System (INIS)

    Mukhopadhyay, Sheela; Srivastava, D.K.; Ganguly, N.K.

    1976-01-01

    A microscopic calculation of composits particle optical potential has been done using a realistic nucleon-helion interaction and folding it with the density distribution of the targets. The second order effects were simulated by introducing a scaling factor which was searched on to reproduce the experimental scattering results. Composite particle optical potential was also derived from the nucleon-nucleus optical potential. The second order term was explicitly treated as a parameter. Elastic scattering of 20 MeV 3 H on targets ranging from 40 Ca to 208 Pb to 208 Pb have also been analysed using phenomenological optical model. Agreement of these results with the above calculations verified the consistency of the microscopic theory. But the equivalent sharp radius calculated with n-helion interaction was observed to be smaller than phenomenological value. This was attributed to the absence of saturation effects in the density-independent interaction used. Saturation has been introduced by a density dependent term of the form (1-c zetasup(2/3)), where zeta is the compound density of the target helion system. (author)

  7. Zeta-function regularization approach to finite temperature effects in Kaluza-Klein space-times

    International Nuclear Information System (INIS)

    Bytsenko, A.A.; Vanzo, L.; Zerbini, S.

    1992-01-01

    In the framework of heat-kernel approach to zeta-function regularization, in this paper the one-loop effective potential at finite temperature for scalar and spinor fields on Kaluza-Klein space-time of the form M p x M c n , where M p is p-dimensional Minkowski space-time is evaluated. In particular, when the compact manifold is M c n = H n /Γ, the Selberg tracer formula associated with discrete torsion-free group Γ of the n-dimensional Lobachevsky space H n is used. An explicit representation for the thermodynamic potential valid for arbitrary temperature is found. As a result a complete high temperature expansion is presented and the roles of zero modes and topological contributions is discussed

  8. On Montgomery's pair correlation conjecture to the zeros of Riedmann zeta function

    OpenAIRE

    Li, Pei

    2005-01-01

    In this thesis, we are interested in Montgomery's pair correlation conjecture which is about the distribution of.the spacings between consecutive zeros of the Riemann Zeta function. Our goal is to explain and study Montgomery's pair correlation conjecture and discuss its connection with the random matrix theory. In Chapter One, we will explain how to define the Ftiemann Zeta function by using the analytic continuation. After this, several classical properties of the Ftiemann Zeta function wil...

  9. A Possible Massive Asteroid Belt Around $\\zeta$ Lep

    CERN Document Server

    Chen Chuan Hung

    2001-01-01

    We have used the Keck I telescope to image at 11.7 microns and 17.9 microns the dust emission around zeta Lep, a main sequence A-type star at 21.5 pc from the Sun with an infrared excess. The excess is at most marginally resolved at 17.9 microns. The dust distance from the star is probably less than or equal to 6 AU, although some dust may extend to 9 AU. The mass of observed dust is \\~10^22 g. Since the lifetime of dust particles is about 10,000 years because of the Poytning-Robertson effect, we robustly estimate at least 4 10^26 g must reside in parent bodies which may be asteroids if the system is in a steady state and has an age of ~300 Myr. This mass is approximately 200 times that contained within the main asteroid belt in our solar system.

  10. Fuzzy-PI-based centralised control of semi-isolated FP-SEPIC/ZETA BDC in a PV/battery hybrid system

    Science.gov (United States)

    Mahendran, Venmathi; Ramabadran, Ramaprabha

    2016-11-01

    Multiport converters with centralised controller have been most commonly used in stand-alone photovoltaic (PV)/battery hybrid system to supply the load smoothly without any disturbances. This study presents the performance analysis of four-port SEPIC/ZETA bidirectional converter (FP-SEPIC/ZETA BDC) using various types of centralised control schemes like Fuzzy tuned proportional integral controller (Fuzzy-PI), fuzzy logic controller (FLC) and conventional proportional integral (PI) controller. The proposed FP-SEPIC/ZETA BDC with various control strategy is derived for simultaneous power management of a PV source using distributed maximum power point tracking (DMPPT) algorithm, a rechargeable battery, and a load by means of centralised controller. The steady state and the dynamic response of the FP-SEPIC/ZETA BDC are analysed using three different types of controllers under line and load regulation. The Fuzzy-PI-based control scheme improves the dynamic response of the system when compared with the FLC and the conventional PI controller. The power balance between the ports is achieved by pseudorandom carrier modulation scheme. The response of the FP-SEPIC/ZETA BDC is also validated experimentally using hardware prototype model of 500 W system. The effectiveness of the control strategy is validated using simulation and experimental results.

  11. Energy development potential: An analysis of Brazil

    International Nuclear Information System (INIS)

    Perobelli, Fernando Salgueiro; Oliveira, Caio Cézar Calheiros de

    2013-01-01

    This paper develops an indicator for the energy development potential (EDP) of 27 Brazilian states. This indicator uses data on a state's infrastructure and its supply of and demand for energy. The indicator measures the data for three periods: the first part of the 1990s, which is a period of low economic growth; the first part of the 2000s, which is a period of high economic growth but with a historical crisis in the Brazilian energy sector; and 2009–2011, which is a period of economic growth after the energy crisis. Using a factor analysis, we are able to identify three factors for EDP. They are the demand for energy, the supply of renewable energy, and the supply of nonrenewable energy. We use these factors to classify the Brazilian states according to their EDP and to perform an exploratory spatial data analysis (ESDA) by using the Moran indicators and the local indicators of spatial association (LISA). - Highlights: • This paper deals with the spatial dimension of the Brazilian energy sector. • We construct an index of the energy development potential for Brazilian states. • Energy issues are defined over time and space, thus have spatial dimensions. • The spatial results show that there are two well-defined spatial patterns

  12. RNA secondary structures in a polymer-zeta model how foldings should be shaped for sparsification to establish a linear speedup

    DEFF Research Database (Denmark)

    Jin, Emma Yu; Nebel, M. E.

    2016-01-01

    that the corresponding conditional probabilities behave according to a polymer-zeta probability model. We show that even if some of the structural parameters exhibit an almost realistic behavior on average, the expected shape of a folding in that model must be assumed to highly differ from those observed in nature. More...... sparsification) may reduce the runtime to n2 on average, assuming that nucleotides of distance d form a hydrogen bond (i.e. are paired) with probability (Formula Presented.) for some constants b > 0, c > 1. The latter is called the polymer-zeta model and plays a crucial role in speeding up the above mentioned...... algorithm. In this paper we discuss the application of the polymer-zeta property for the analysis of sparsification, showing that it must be applied conditionally on first and last positions to pair. Afterwards, we will investigate the combinatorics of RNA secondary structures assuming...

  13. Zeta Function Expression of Spin Partition Functions on Thermal AdS3

    Directory of Open Access Journals (Sweden)

    Floyd L.Williams

    2015-07-01

    Full Text Available We find a Selberg zeta function expression of certain one-loop spin partition functions on three-dimensional thermal anti-de Sitter space. Of particular interest is the partition function of higher spin fermionic particles. We also set up, in the presence of spin, a Patterson-type formula involving the logarithmic derivative of zeta.

  14. Note on asymptotic series expansions for the derivative of the Hurwitz zeta function and related functions

    International Nuclear Information System (INIS)

    Rudaz, S.

    1990-01-01

    Asymptotic series for the Hurwitz zeta function, its derivative, and related functions (including the Riemann zeta function of odd integer argument) are derived as an illustration of a simple, direct method of broad applicability, inspired by the calculus of finite differences

  15. Generalized Riemann zeta-function regularization and Casimir energy for a piecewise uniform string

    International Nuclear Information System (INIS)

    Li Xinzhou; Shi Xin; Zhang Jianzu.

    1990-12-01

    The generalized zeta-function techniques will be utilized to investigate the Casimir energy for the transverse oscillations of a piecewise uniform closed string. We find that zeta-function regularization method can lead straightforwardly to a correct result. (author). 6 refs

  16. Multivariate meta-analysis: Potential and promise

    Science.gov (United States)

    Jackson, Dan; Riley, Richard; White, Ian R

    2011-01-01

    The multivariate random effects model is a generalization of the standard univariate model. Multivariate meta-analysis is becoming more commonly used and the techniques and related computer software, although continually under development, are now in place. In order to raise awareness of the multivariate methods, and discuss their advantages and disadvantages, we organized a one day ‘Multivariate meta-analysis’ event at the Royal Statistical Society. In addition to disseminating the most recent developments, we also received an abundance of comments, concerns, insights, critiques and encouragement. This article provides a balanced account of the day's discourse. By giving others the opportunity to respond to our assessment, we hope to ensure that the various view points and opinions are aired before multivariate meta-analysis simply becomes another widely used de facto method without any proper consideration of it by the medical statistics community. We describe the areas of application that multivariate meta-analysis has found, the methods available, the difficulties typically encountered and the arguments for and against the multivariate methods, using four representative but contrasting examples. We conclude that the multivariate methods can be useful, and in particular can provide estimates with better statistical properties, but also that these benefits come at the price of making more assumptions which do not result in better inference in every case. Although there is evidence that multivariate meta-analysis has considerable potential, it must be even more carefully applied than its univariate counterpart in practice. Copyright © 2011 John Wiley & Sons, Ltd. PMID:21268052

  17. Analysis of CDM projects’ potential benefits

    Directory of Open Access Journals (Sweden)

    José Affonso dos Reis Junior

    2015-11-01

    Full Text Available Objective – The main goal of this study is to identify and assess, within sustainability reports, information concerning potential carbon credits obtained through projects carried out under Clean Development Mechanism (CDM assumptions, as well as to assess CDM project experts’ perceptions of obstacles to entering carbon credit markets. Design/methodology/approach – exploratory, descriptive, bibliographical and documental research, and interviews. Theoretical basis - Research was based on the concepts of sustainability, especially as to environmental responsibility (CSR; cost-benefit analysis was also considered, since selling carbon credits can be a way of mitigating the trade off between immediate shareholder satisfaction and investment in CSR. Findings – The perceptions of representatives from carbon credit projects’ certifying companies was examined by means of a series of interviews – concluding that savings in costs, business marketing and certifications are even greater motivators than carbon credits themselves. We estimated that, through energy efficiency, the projects discussed in 2011 sustainability reports would be capable of saving approximately 538 million reais in costs. In addition, 40 million reais, considering the rate of the euro and of securities on December 31, 2014, would be gained through the sale of carbon credits. Practical implications – Thus, this research helps to demonstrate the significant potential for further financial gains that companies may obtain through energy efficiency and habitat restructuring, whether by taking advantage of CO2 reduction brought about by such projects, or by developing new projects that continue to benefit economy, society and the environment.

  18. Detection of interstellar (C-13)N toward Zeta Ophiuchi

    International Nuclear Information System (INIS)

    Crane, P.; Hegyi, D.J.

    1988-01-01

    Observations of a diffuse interstellar cloud toward Zeta Oph, obtained with resolution 100,000-150,000 near the 3874.608-A R(0) line of (C-12)N using a coude echelle spectrograph on the 1.4-m telescope at ESO during 1984 and 1985, are reported. Data from 54 20-min runs were fitted to Gaussian line shapes using the line center, depth, and width of the R(0) and R(1) lines of (C-12)N and the line center and depth of the R(0) line of (C-13)N as fitting parameters. The (C-13)N R(0) line, with equivalent width 0.190 + or - 0.020 mA, was detected 173.7 + or - 0.8 mA to the red of (C-12)N R(0); the corresponding isotope abundance ratio, (C-12)N/(C-13)N = 47.3 + 5.5 or -4.4, is shown to be in good agreement with previous measurements for CH(+) (Hawkins et al., 1985). 13 references

  19. On the $a$-points of the derivatives of the Riemann zeta function

    OpenAIRE

    Onozuka, Tomokazu

    2016-01-01

    We prove three results on the $a$-points of the derivatives of the Riemann zeta function. The first result is a formula of the Riemann-von Mangoldt type; we estimate the number of the $a$-points of the derivatives of the Riemann zeta function. The second result is on certain exponential sum involving $a$-points. The third result is an analogue of the zero density theorem. We count the $a$-points of the derivatives of the Riemann zeta function in $1/2-(\\log\\log T)^2/\\log T

  20. ANALYSIS OF CHP POTENTIAL AT FEDERAL SITES

    Energy Technology Data Exchange (ETDEWEB)

    HADLEY, S.W.

    2002-03-11

    of these criteria. Executive Order 13123 directs federal facilities to use CHP when life-cycle costs indicate energy reduction goals will be met. FEMP can assist facilities to conduct this analysis. The model developed for this report estimates the magnitude of CHP that could be implemented under various performance and economic assumptions associated with different applications. This model may be useful for other energy technologies. It can be adapted to estimate the market potential in federal buildings for any energy system based on the cost and performance parameters that a user desires to assess. The model already incorporates a standard set of parameters based on available data for federal buildings including total building space, building type, energy use intensity, fuel costs, and the performance of many prime movers commonly used in CHP applications. These and other variables can be adjusted to meet user needs or updated in the future as new data become available.

  1. Zeta-function regularization of the quantum fluctuations around the Yang-Mills pseudoparticle

    International Nuclear Information System (INIS)

    Chadha, S.; Di Vecchia, P.; D'Adda, A.; Nicodemi, F.

    1977-01-01

    The hypersphere stereographic projection and the zeta-function regularization procedure are used to compute the one loop correction around the Yang-Mills pseudoparticle with scalars and fermions in an arbitrary representation of the SU(2) gauge group. (Auth.)

  2. Instabilities of the zeta-function regularization in the presence of symmetries

    International Nuclear Information System (INIS)

    Rasetti, M.

    1980-01-01

    The zeta-function regularization method requires the calculation of the spectrum-generating function zeta sub(M) of a generic real, elliptic, self-adjoint differential operator on a manifold M. An asymptotic expansion for zeta sub(M) is given for the class of all symmetric spaces of rank 1, sufficient to compute its Mellin transform and deduce the regularization of the corresponding quadratic path integrals. The summability properties of the generalized zeta-function introduce physical instabilities in the system as negative specific heat. The technique (and the instability as well) is shown to hold - under the assumed symmetry properties - in any dimension (preserving both the global and local properties of the manifold, as opposed to the dimensional regularization, where one adds extra flat dimensions only). (author)

  3. Probability laws related to the Jacobi theta and Riemann zeta function and Brownian excursions

    OpenAIRE

    Biane, P.; Pitman, J.; Yor, M.

    1999-01-01

    This paper reviews known results which connect Riemann's integral representations of his zeta function, involving Jacobi's theta function and its derivatives, to some particular probability laws governing sums of independent exponential variables. These laws are related to one-dimensional Brownian motion and to higher dimensional Bessel processes. We present some characterizations of these probability laws, and some approximations of Riemann's zeta function which are related to these laws.

  4. Habitat Analysis - Trinity River Restoration Potential

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of the Trinity River project is to identify the potential positive effects of large-scale restoration actions in a 63 kilometer reach of the Trinity River...

  5. Geomorphic Analysis - Trinity River Restoration Potential

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of the Trinity River project is to identify the potential positive effects of large-scale restoration actions in a 63 kilometer reach of the Trinity River...

  6. Stability analysis in tachyonic potential chameleon cosmology

    International Nuclear Information System (INIS)

    Farajollahi, H.; Salehi, A.; Tayebi, F.; Ravanpak, A.

    2011-01-01

    We study general properties of attractors for tachyonic potential chameleon scalar-field model which possess cosmological scaling solutions. An analytic formulation is given to obtain fixed points with a discussion on their stability. The model predicts a dynamical equation of state parameter with phantom crossing behavior for an accelerating universe. We constrain the parameters of the model by best fitting with the recent data-sets from supernovae and simulated data points for redshift drift experiment generated by Monte Carlo simulations

  7. Stability analysis in tachyonic potential chameleon cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Farajollahi, H.; Salehi, A.; Tayebi, F.; Ravanpak, A., E-mail: hosseinf@guilan.ac.ir, E-mail: a.salehi@guilan.ac.ir, E-mail: ftayebi@guilan.ac.ir, E-mail: aravanpak@guilan.ac.ir [Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of)

    2011-05-01

    We study general properties of attractors for tachyonic potential chameleon scalar-field model which possess cosmological scaling solutions. An analytic formulation is given to obtain fixed points with a discussion on their stability. The model predicts a dynamical equation of state parameter with phantom crossing behavior for an accelerating universe. We constrain the parameters of the model by best fitting with the recent data-sets from supernovae and simulated data points for redshift drift experiment generated by Monte Carlo simulations.

  8. Composition dependence of the thermodynamic activity and lattice parameter of zeta nickel-indium

    International Nuclear Information System (INIS)

    Bhattacharya, B.; Masson, D.B.

    1976-01-01

    The vapor pressure of indium over six alloys in the zeta phase of the nickel-indium system was measured by the method of atomic absorption. Values of thermodynamic activity were calculated from the vapor pressure, and partial heat and entropy of indium were calculated from the temperature coefficients. The lattice parameters of the hexagonal B8 2 unit cell of all alloys were calculated from X-ray diffraction powder patterns. It was found that the a lattice parameter passed through a minimum at the same composition that the excess chemical potential showed a sharp change of slope, when graphed as a function of composition. These effects were similar to those observed previously which have been attributed to overlap by the Fermi surface of a Brillouin zone face. In the present case they were attributed to overlap of the Fermi surface across faces tentatively identified as the [110] faces of the Brillouin zone of the B8 2 structure. The influence of substitutional disorder was also considered as a cause of the thermodynamic effects, but this was rejected because it does not explain the minimum in lattice parameter. (Auth.)

  9. Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats

    Directory of Open Access Journals (Sweden)

    Jena B. Hales

    2015-01-01

    Full Text Available Spatial memory in rodents can be erased following the infusion of zeta inhibitory peptide (ZIP into the dorsal hippocampus via indwelling guide cannulas. It is believed that ZIP impairs spatial memory by reversing established late-phase long-term potentiation (LTP. However, it is unclear whether other forms of hippocampus-dependent memory, such as recognition memory, are also supported by hippocampal LTP. In the current study, we tested recognition memory in rats following hippocampal ZIP infusion. In order to combat the limited targeting of infusions via cannula, we implemented a stereotaxic approach for infusing ZIP throughout the dorsal, intermediate, and ventral hippocampus. Rats infused with ZIP 3–7 days after training on the novel object recognition task exhibited impaired object recognition memory compared to control rats (those infused with aCSF. In contrast, rats infused with ZIP 1 month after training performed similar to control rats. The ability to form new memories after ZIP infusions remained intact. We suggest that enhanced recognition memory for recent events is supported by hippocampal LTP, which can be reversed by hippocampal ZIP infusion.

  10. Zeta functions for the spectrum of the non-commutative harmonic oscillators

    CERN Document Server

    Ichinose, T

    2004-01-01

    This paper investigates the spectral zeta function of the non-commutative harmonic oscillator studied in \\cite{PW1, 2}. It is shown, as one of the basic analytic properties, that the spectral zeta function is extended to a meromorphic function in the whole complex plane with a simple pole at $s=1$, and further that it has a zero at all non-positive even integers, i.e. at $s=0$ and at those negative even integers where the Riemann zeta function has the so-called trivial zeros. As a by-product of the study, both the upper and the lower bounds are also given for the first eigenvalue of the non-commutative harmonic oscillator.

  11. Zeta functions and regularized determinants related to the Selberg trace formula

    DEFF Research Database (Denmark)

    Momeni, Arash; Venkov, Alexei

    determinants of one dimensional Schroedinger operator for harmonic oscillator. We decompose the determinant of the automorphic Laplacian into a product of the determinants where each factor is a determinant representation of a zeta function related to Selberg's trace formula. Then we derive an identity...... connecting the determinants of the automorphic Laplacians on different Riemannian surfaces related to the arithmetical groups. Finally, by using the Jacquet-Langlands correspondence we connect the determinant of the automorphic Laplacian for the unit group of quaternions to the product of the determinants......For a general Fuchsian group of the first kind with an arbitrary unitary representation we define the zeta functions related to the contributions of the identity, hyperbolic, elliptic and parabolic conjugacy classes in Selberg's trace formula. We present Selberg's zeta function in terms...

  12. LETTER TO THE EDITOR: Fractal diffusion coefficient from dynamical zeta functions

    Science.gov (United States)

    Cristadoro, Giampaolo

    2006-03-01

    Dynamical zeta functions provide a powerful method to analyse low-dimensional dynamical systems when the underlying symbolic dynamics is under control. On the other hand, even simple one-dimensional maps can show an intricate structure of the grammar rules that may lead to a non-smooth dependence of global observables on parameters changes. A paradigmatic example is the fractal diffusion coefficient arising in a simple piecewise linear one-dimensional map of the real line. Using the Baladi-Ruelle generalization of the Milnor-Thurnston kneading determinant, we provide the exact dynamical zeta function for such a map and compute the diffusion coefficient from its smallest zero.

  13. Zeta Function Regularization in Casimir Effect Calculations and J. S. Dowker's Contribution

    Science.gov (United States)

    Elizalde, Emilio

    2012-07-01

    A summary of relevant contributions, ordered in time, to the subject of operator zeta functions and their application to physical issues is provided. The description ends with the seminal contributions of Stephen Hawking and Stuart Dowker and collaborators, considered by many authors as the actual starting point of the introduction of zeta function regularization methods in theoretical physics, in particular, for quantum vacuum fluctuation and Casimir effect calculations. After recalling a number of the strengths of this powerful and elegant method, some of its limitations are discussed. Finally, recent results of the so called operator regularization procedure are presented.

  14. Effective action for scalar fields and generalized zeta-function regularization

    International Nuclear Information System (INIS)

    Cognola, Guido; Zerbini, Sergio

    2004-01-01

    Motivated by the study of quantum fields in a Friedmann-Robertson-Walker space-time, the one-loop effective action for a scalar field defined in the ultrastatic manifold RxH 3 /Γ, H 3 /Γ being the finite volume, noncompact, hyperbolic spatial section, is investigated by a generalization of zeta-function regularization. It is shown that additional divergences may appear at the one-loop level. The one-loop renormalizability of the model is discussed and, making use of a generalization of zeta-function regularization, the one-loop renormalization group equations are derived

  15. Interaction of nucleosome assembly proteins abolishes nuclear localization of DGK{zeta} by attenuating its association with importins

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Masashi; Hozumi, Yasukazu [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Ichimura, Tohru [Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji 192-0397 (Japan); Tanaka, Toshiaki; Hasegawa, Hiroshi; Yamamoto, Masakazu; Takahashi, Nobuya [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Iseki, Ken [Department of Emergency and Critical Care Medicine, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Yagisawa, Hitoshi [Laboratory of Biological Signaling, Graduate School of Life Science, University of Hyogo, Hyogo 678-1297 (Japan); Shinkawa, Takashi; Isobe, Toshiaki [Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji 192-0397 (Japan); Goto, Kaoru, E-mail: kgoto@med.id.yamagata-u.ac.jp [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan)

    2011-12-10

    Diacylglycerol kinase (DGK) is involved in the regulation of lipid-mediated signal transduction through the metabolism of a second messenger diacylglycerol. Of the DGK family, DGK{zeta}, which contains a nuclear localization signal, localizes mainly to the nucleus but translocates to the cytoplasm under pathological conditions. However, the detailed mechanism of translocation and its functional significance remain unclear. To elucidate these issues, we used a proteomic approach to search for protein targets that interact with DGK{zeta}. Results show that nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGK{zeta} binding partners. NAP1Ls constitutively shuttle between the nucleus and the cytoplasm in transfected HEK293 cells. The molecular interaction of DGK{zeta} and NAP1Ls prohibits nuclear import of DGK{zeta} because binding of NAP1Ls to DGK{zeta} blocks import carrier proteins, Qip1 and NPI1, to interact with DGK{zeta}, leading to cytoplasmic tethering of DGK{zeta}. In addition, overexpression of NAP1Ls exerts a protective effect against doxorubicin-induced cytotoxicity. These findings suggest that NAP1Ls are involved in a novel molecular basis for the regulation of nucleocytoplasmic shuttling of DGK{zeta} and provide a clue to examine functional significance of its translocation under pathological conditions.

  16. Zeros da função zeta de Riemann e o teorema dos números primos

    OpenAIRE

    Oliveira, Willian Diego [UNESP

    2013-01-01

    We studied various properties of the Riemann’s zeta function. Three proofs of the Prime Number Theorem were provides. Classical results on zero-free region of the zeta function, as well as their relation to the error term in the Prime Number Theorem, were studied in details Estudamos várias propriedades da função zeta de Riemann. Três provas do Teorema dos Números Primos foram fornecidas. Resultados clássicos sobre regiões livres de zeros da função zeta, bem como sua relação com o termo do...

  17. Broadway teatrites näeb Denzel Washingtoni ja Catherine Zeta-Jonesi / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    New Yorgis välja antud Tony teatriauhinna pälvisid filminäitlejad Denzel Washington, Catherine Zeta-Jones ja Scarlett Johansson. Parim lavale naasnud näidend - "Piirdeaed", parim uus näidend - draama "Punane", mis räägib läti päritolu maalikunstnikust Mark Rothkost. Parim muusikal - "Memphis"

  18. Certain Subclasses of Analytic and Bi-Univalent Functions Involving Double Zeta Functions

    OpenAIRE

    Siregar, Saibah; Raman, Sintuja

    2012-01-01

    In the present paper, we introduce two new subclasses of the functions class Σ of bi-univalent functions involving double zeta functions in the open unit disc U={z:zEC, |z|<1}. The estimates on the coefficients |a2| and |a3| for functions in these new subclasses of the function class Σ are obtained in our investigation.

  19. "Armastuse retsepti" tippkokk Zeta Jones ei oska muna keeta / Triin Tael

    Index Scriptorium Estoniae

    Tael, Triin

    2007-01-01

    Scott Hicksi romantiline komöödiafilm "Armastuse retsept" ("No Reservations"), mille peaosas Walesist pärit näitlejanna Catherine Zeta Jones. Näitlejanna muljeid oma rolliks ettevalmistustest, mille hulka käis ka praktika pärisrestoranis

  20. Boundary Conditions for the Maintenance of Memory by PKM[zeta] in Neocortex

    Science.gov (United States)

    Shema, Reul; Hazvi, Shoshi; Sacktor, Todd C.; Dudai, Yadin

    2009-01-01

    We report here that ZIP, a selective inhibitor of the atypical protein kinase C isoform PKM[zeta], abolishes very long-term conditioned taste aversion (CTA) associations in the insular cortex of the behaving rat, at least 3 mo after encoding. The effect of ZIP is not replicated by a general serine/threonine protein kinase inhibitor that is…

  1. Critical dimension of bosonic string theory and zeta-function regularization

    International Nuclear Information System (INIS)

    Vanzo, L.; Zerbini, S.; Istituto Nazionale di Fisica Nucleare, Povo

    1988-01-01

    A derivation of the critical dimension of the Polyakov bosonic string is presented. It is based on the use of the anholonomic formalism, a ghost-anti-ghost symmetric action, zeta-function regularization and the Seeley method of pseudo-differential operators. (orig.)

  2. MOLECULAR ANALYSIS OF HUMAN SPERMATOZOA: POTENTIAL FOR INFERTILITY RESEARCH

    Science.gov (United States)

    Gordon Research Conference: Mammalian Gametogenesis and Embryogenesis New London, CT, July 1-6, 2000Molecular Analysis of Human Spermatozoa: Potential for Infertility ResearchDavid Miller 1, David Dix2, Robert Reid 3, Stephen A Krawetz 3 1Reproductive ...

  3. Analysis of the normal optical, Michel and molecular potentials on ...

    Indian Academy of Sciences (India)

    6. — journal of. June 2016 physics pp. 1275–1286. Analysis of the normal ... the levels are obtained for the three optical potentials to estimate the quality ... The experimental angular distribution data for the 40Ca(6Li, d)44Ti reaction .... analysed using the normal optical, Michel and molecular potentials within the framework.

  4. The interaction between saliva and Actinobacillus actinomycetemcomitans influenced by the Zeta potential

    NARCIS (Netherlands)

    Groenink, J; Veerman, ECI; Zandvoort, MS; van der Mei, HC; Busscher, HJ; Amerongen, AVN

    The adhesion of Actinobacillus actinomycetemcomitans is a virulence factor in the aetiology of periodontitis and is determined by physico-chemical properties, e.g. surface charge and hydrophobicity, of the bacterial cell surface. Although oral surfaces are constantly coated with saliva, few studies

  5. Commentary: Using Potential Outcomes to Understand Causal Mediation Analysis

    Science.gov (United States)

    Imai, Kosuke; Jo, Booil; Stuart, Elizabeth A.

    2011-01-01

    In this commentary, we demonstrate how the potential outcomes framework can help understand the key identification assumptions underlying causal mediation analysis. We show that this framework can lead to the development of alternative research design and statistical analysis strategies applicable to the longitudinal data settings considered by…

  6. Special values of the spectral zeta function of the non-commutative harmonic oscillator and confluent Heun equations

    CERN Document Server

    Ichinose, T

    2004-01-01

    We study the special values at $s=2$ and $3$ of the spectral zeta function $\\zeta_Q(s)$ of the non-commutative harmonic oscillator $Q(x,D_x)$ introduced in \\cite{PW1, 2}. It is shown that the series defining $\\zeta_Q(s)$ converges absolutely for Re $s>1$ and further the respective values $\\zeta_Q(2)$ and $\\zeta_Q(3)$ are represented essentially by contour integrals of the solutions, respectively, of a singly confluent Heun's ordinary differential equation and of exactly the same but an inhomogeneous equation. As a by-product of these results, we obtain integral representations of the solutions of these equations by rational functions. \\par\

  7. Non-Commutative Integration, Zeta Functions and the Haar State for SU{sub q}(2)

    Energy Technology Data Exchange (ETDEWEB)

    Matassa, Marco, E-mail: marco.matassa@gmail.com [SISSA (Italy)

    2015-12-15

    We study a notion of non-commutative integration, in the spirit of modular spectral triples, for the quantum group SU{sub q}(2). In particular we define the non-commutative integral as the residue at the spectral dimension of a zeta function, which is constructed using a Dirac operator and a weight. We consider the Dirac operator introduced by Kaad and Senior and a family of weights depending on two parameters, which are related to the diagonal automorphisms of SU{sub q}(2). We show that, after fixing one of the parameters, the non-commutative integral coincides with the Haar state of SU{sub q}(2). Moreover we can impose an additional condition on the zeta function, which also fixes the second parameter. For this unique choice the spectral dimension coincides with the classical dimension.

  8. Averages of ratios of the Riemann zeta-function and correlations of divisor sums

    Science.gov (United States)

    Conrey, Brian; Keating, Jonathan P.

    2017-10-01

    Nonlinearity has published articles containing a significant number-theoretic component since the journal was first established. We examine one thread, concerning the statistics of the zeros of the Riemann zeta function. We extend this by establishing a connection between the ratios conjecture for the Riemann zeta-function and a conjecture concerning correlations of convolutions of Möbius and divisor functions. Specifically, we prove that the ratios conjecture and an arithmetic correlations conjecture imply the same result. This provides new support for the ratios conjecture, which previously had been motivated by analogy with formulae in random matrix theory and by a heuristic recipe. Our main theorem generalises a recent calculation pertaining to the special case of two-over-two ratios.

  9. Resonance chains in open systems, generalized zeta functions and clustering of the length spectrum

    International Nuclear Information System (INIS)

    Barkhofen, S; Faure, F; Weich, T

    2014-01-01

    In many non-integrable open systems in physics and mathematics, resonances have been found to be surprisingly ordered along curved lines in the complex plane. In this article we provide a unifying approach to these resonance chains by generalizing dynamical zeta functions. By means of a detailed numerical study we show that these generalized zeta functions explain the mechanism that creates the chains of quantum resonance and classical Ruelle resonances for three-disk systems as well as geometric resonances on Schottky surfaces. We also present a direct system-intrinsic definition of the continuous lines on which the resonances are strung together as a projection of an analytic variety. Additionally, this approach shows that the existence of resonance chains is directly related to a clustering of the classical length spectrum on multiples of a base length. Finally, this link is used to construct new examples where several different structures of resonance chains coexist. (paper)

  10. Non-Commutative Integration, Zeta Functions and the Haar State for SUq(2)

    International Nuclear Information System (INIS)

    Matassa, Marco

    2015-01-01

    We study a notion of non-commutative integration, in the spirit of modular spectral triples, for the quantum group SU q (2). In particular we define the non-commutative integral as the residue at the spectral dimension of a zeta function, which is constructed using a Dirac operator and a weight. We consider the Dirac operator introduced by Kaad and Senior and a family of weights depending on two parameters, which are related to the diagonal automorphisms of SU q (2). We show that, after fixing one of the parameters, the non-commutative integral coincides with the Haar state of SU q (2). Moreover we can impose an additional condition on the zeta function, which also fixes the second parameter. For this unique choice the spectral dimension coincides with the classical dimension

  11. Unusual poles of the {zeta}-functions for some regular singular differential operators

    Energy Technology Data Exchange (ETDEWEB)

    Falomir, H [IFLP, Departamento de Fisica-Facultad de Ciencias Exactas, UNLP, CC 67 (1900) La Plata (Argentina); Muschietti, M A [Departamento de Matematica-Facultad de Ciencias Exactas, UNLP, CC 172 (1900) La Plata (Argentina); Pisani, P A G [IFLP, Departamento de Fisica-Facultad de Ciencias Exactas, UNLP, CC 67 (1900) La Plata (Argentina); Seeley, R [University of Massachusetts at Boston, Boston, MA 02125 (United States)

    2003-10-03

    We consider the resolvent of a system of first-order differential operators with a regular singularity, admitting a family of self-adjoint extensions. We find that the asymptotic expansion for the resolvent in the general case presents powers of {lambda} which depend on the singularity, and can take even irrational values. The consequences for the pole structure of the corresponding {zeta}- and {eta}-functions are also discussed.

  12. Fractal zeta functions and fractal drums higher-dimensional theory of complex dimensions

    CERN Document Server

    Lapidus, Michel L; Žubrinić, Darko

    2017-01-01

    This monograph gives a state-of-the-art and accessible treatment of a new general higher-dimensional theory of complex dimensions, valid for arbitrary bounded subsets of Euclidean spaces, as well as for their natural generalization, relative fractal drums. It provides a significant extension of the existing theory of zeta functions for fractal strings to fractal sets and arbitrary bounded sets in Euclidean spaces of any dimension. Two new classes of fractal zeta functions are introduced, namely, the distance and tube zeta functions of bounded sets, and their key properties are investigated. The theory is developed step-by-step at a slow pace, and every step is well motivated by numerous examples, historical remarks and comments, relating the objects under investigation to other concepts. Special emphasis is placed on the study of complex dimensions of bounded sets and their connections with the notions of Minkowski content and Minkowski measurability, as well as on fractal tube formulas. It is shown for the f...

  13. Acoustic analysis of warp potential of green ponderosa pine lumber

    Science.gov (United States)

    Xiping Wang; William T. Simpson

    2005-01-01

    This study evaluated the potential of acoustic analysis as presorting criteria to identify warp-prone boards before kiln drying. Dimension lumber, 38 by 89 mm (nominal 2 by 4 in.) and 2.44 m (8 ft) long, sawn from open-grown small-diameter ponderosa pine trees, was acoustically tested lengthwise at green condition. Three acoustic properties (acoustic speed, rate of...

  14. Wind and area potential analysis of the Lower Saxony coast

    International Nuclear Information System (INIS)

    Pahlke, T.; Gerdes, G.; Keuper, A.

    1993-01-01

    An analysis of the wind and area potential is carried out for 10 areas at the Lower Saxony coast, on behalf of the Lower Saxony Ministry of the Environment. The processes for determining suitable areas, the wind speeds and the possible amounts of energy are introduced. (orig.) [de

  15. Resolution of potential ambiguities through farside angular structure: Semiclassical analysis

    International Nuclear Information System (INIS)

    Fricke, S.H.; Brandan, M.E.; McVoy, K.W.

    1988-01-01

    The optical potential fits summarized in the preceding paper are subjected to a semiclassical analysis of the Ford-Wheeler--Knoll-Schaeffer type. The important broad dips in their farside cross sections, which are essential in greatly reducing potential ambiguities, are found (in partial agreement with a suggestion of Goldberg's) to be mainly weak ''Airy'' or rainbow minima, that serve to identify deeply penetrating trajectories. The semiclassical analysis also permits the identification and understanding of a new category of discrete and continuous potential ambiguities, and suggests the manner in which specific features of the angular distributions (such as spacings and depths of various angular minima) determine the Woods-Saxon parameters found by a chi-squared search

  16. Analysis of the Industry Potential in Republic of Moldova

    Directory of Open Access Journals (Sweden)

    Larisa BUGAIAN

    2010-12-01

    Full Text Available This article identifies several competitive sectors of the economy that have potential to lead to sustainable economic growth for Republic of Moldova. Sectors were chosen for analysis combining quantitative and qualitative methods. A pool of sectors was selected based on export and sales performance over the last eight years. The final decision of the top sectors was based on the qualitative factors such as prevalence of the SMEs in the sector, gender makeup of the workforce and the regional presence, as well as employment levels and sales growth. The results of analysis showed that following industrial sectors: wine; textiles and apparel; information and communication technology; footwear; construction materials and furniture have the most potential for contributing to transformational growth in the Republic of Moldova economy.

  17. Statistical properties of the zeros of zeta functions - beyond the Riemann case

    International Nuclear Information System (INIS)

    Bogomolny, E.; Leboeuf, P.

    1993-09-01

    The statistical distribution of the zeros of Dirichlet L-functions is investigated both analytically and numerically. Using the Hardy-Littlewood conjecture about the distribution of primes it is shown that the two-point correlation function of these zeros coincides with that for eigenvalues of the Gaussian unitary ensemble of random matrices, and that the distributions of zeros of different L-functions are statistically independent. Applications of these results to Epstein's zeta functions are shortly discussed. (authors) 30 refs., 3 figs., 1 tab

  18. Fractional parts and their relations to the values of the Riemann zeta function

    KAUST Repository

    Alabdulmohsin, Ibrahim

    2017-09-06

    A well-known result, due to Dirichlet and later generalized by de la Vallée–Poussin, expresses a relationship between the sum of fractional parts and the Euler–Mascheroni constant. In this paper, we prove an asymptotic relationship between the summation of the products of fractional parts with powers of integers on the one hand, and the values of the Riemann zeta function, on the other hand. Dirichlet’s classical result falls as a particular case of this more general theorem.

  19. On the irrationality measure for a q-analogue of \\zeta(2)

    Science.gov (United States)

    Zudilin, W. V.

    2002-08-01

    A Liouville-type estimate is proved for the irrationality measure of the quantities \\displaystyle \\zeta_q(2)=\\sum_{n=1}^\\infty\\frac{q^n}{(1-q^n)^2}with q^{-1}\\in\\mathbb Z\\setminus\\{0,\\pm1\\}. The proof is based on the application of a q-analogue of the arithmetic method developed by Chudnovsky, Rukhadze, and Hata and of the transformation group for hypergeometric series-the group-structure approach introduced by Rhin and Viola.

  20. Fractional parts and their relations to the values of the Riemann zeta function

    KAUST Repository

    Alabdulmohsin, Ibrahim

    2017-01-01

    A well-known result, due to Dirichlet and later generalized by de la Vallée–Poussin, expresses a relationship between the sum of fractional parts and the Euler–Mascheroni constant. In this paper, we prove an asymptotic relationship between the summation of the products of fractional parts with powers of integers on the one hand, and the values of the Riemann zeta function, on the other hand. Dirichlet’s classical result falls as a particular case of this more general theorem.

  1. Applications of Wirtinger Inequalities on the Distribution of Zeros of the Riemann Zeta-Function

    Directory of Open Access Journals (Sweden)

    Saker SamirH

    2010-01-01

    Full Text Available On the hypothesis that the th moments of the Hardy -function are correctly predicted by random matrix theory and the moments of the derivative of are correctly predicted by the derivative of the characteristic polynomials of unitary matrices, we establish new large spaces between the zeros of the Riemann zeta-function by employing some Wirtinger-type inequalities. In particular, it is obtained that which means that consecutive nontrivial zeros often differ by at least 6.1392 times the average spacing.

  2. Hearing the music of the primes: auditory complementarity and the siren song of zeta

    International Nuclear Information System (INIS)

    Berry, M V

    2012-01-01

    A counting function for the primes can be rendered as a sound signal whose harmonies, spanning the gamut of musical notes, are the Riemann zeros. But the individual primes cannot be discriminated as singularities in this ‘music’, because the intervals between them are too short. Conversely, if the prime singularities are detected as a series of clicks, the Riemann zeros correspond to frequencies too low to be heard. The sound generated by the Riemann zeta function itself is very different: a rising siren howl, which can be understood in detail from the Riemann–Siegel formula. (fast track communication)

  3. Streaming Potential and Electroosmosis Measurements to Characterize Porous Materials

    NARCIS (Netherlands)

    Luong, D.T.; Sprik, R.

    2013-01-01

    Characterizing the streaming potential and electroosmosis properties of porous media is essential in applying seismoelectric and electroseismic phenomena for oil exploration. Some parameters such as porosity, permeability, formation factor, pore size, the number of pores, and the zeta potential of

  4. Higher order statistical moment application for solar PV potential analysis

    Science.gov (United States)

    Basri, Mohd Juhari Mat; Abdullah, Samizee; Azrulhisham, Engku Ahmad; Harun, Khairulezuan

    2016-10-01

    Solar photovoltaic energy could be as alternative energy to fossil fuel, which is depleting and posing a global warming problem. However, this renewable energy is so variable and intermittent to be relied on. Therefore the knowledge of energy potential is very important for any site to build this solar photovoltaic power generation system. Here, the application of higher order statistical moment model is being analyzed using data collected from 5MW grid-connected photovoltaic system. Due to the dynamic changes of skewness and kurtosis of AC power and solar irradiance distributions of the solar farm, Pearson system where the probability distribution is calculated by matching their theoretical moments with that of the empirical moments of a distribution could be suitable for this purpose. On the advantage of the Pearson system in MATLAB, a software programming has been developed to help in data processing for distribution fitting and potential analysis for future projection of amount of AC power and solar irradiance availability.

  5. Algorithms for Some Euler-Type Identities for Multiple Zeta Values

    Directory of Open Access Journals (Sweden)

    Shifeng Ding

    2013-01-01

    Full Text Available Multiple zeta values are the numbers defined by the convergent series ζ(s1,s2,…,sk=∑n1>n2>⋯>nk>0(1/n1s1 n2s2⋯nksk, where s1, s2, …, sk are positive integers with s1>1. For k≤n, let E(2n,k be the sum of all multiple zeta values with even arguments whose weight is 2n and whose depth is k. The well-known result E(2n,2=3ζ(2n/4 was extended to E(2n,3 and E(2n,4 by Z. Shen and T. Cai. Applying the theory of symmetric functions, Hoffman gave an explicit generating function for the numbers E(2n,k and then gave a direct formula for E(2n,k for arbitrary k≤n. In this paper we apply a technique introduced by Granville to present an algorithm to calculate E(2n,k and prove that the direct formula can also be deduced from Eisenstein's double product.

  6. Mutations in the maize zeta-carotene desaturase gene lead to viviparous kernel.

    Directory of Open Access Journals (Sweden)

    Yan Chen

    Full Text Available Preharvest sprouting reduces the maize quality and causes a significant yield loss in maize production. vp-wl2 is a Mutator (Mu-induced viviparous mutant in maize, causing white or pale yellow kernels, dramatically reduced carotenoid and ABA content, and a high level of zeta-carotene accumulation. Here, we reported the cloning of the vp-wl2 gene using a modified digestion-ligation-amplification method (DLA. The results showed that an insertion of Mu9 in the first intron of the zeta-carotene desaturase (ZDS gene results in the vp-wl2 mutation. Previous studies have suggested that ZDS is likely the structural gene of the viviparous9 (vp9 locus. Therefore, we performed an allelic test using vp-wl2 and three vp9 mutants. The results showed that vp-wl2 is a novel allele of the vp9 locus. In addition, the sequences of ZDS gene were identified in these three vp9 alleles. The vp-wl2 mutant gene was subsequently introgressed into four maize inbred lines, and a viviparous phenotype was observed with yield losses from 7.69% to 13.33%.

  7. Protecting Privacy of Shared Epidemiologic Data without Compromising Analysis Potential

    Directory of Open Access Journals (Sweden)

    John Cologne

    2012-01-01

    Full Text Available Objective. Ensuring privacy of research subjects when epidemiologic data are shared with outside collaborators involves masking (modifying the data, but overmasking can compromise utility (analysis potential. Methods of statistical disclosure control for protecting privacy may be impractical for individual researchers involved in small-scale collaborations. Methods. We investigated a simple approach based on measures of disclosure risk and analytical utility that are straightforward for epidemiologic researchers to derive. The method is illustrated using data from the Japanese Atomic-bomb Survivor population. Results. Masking by modest rounding did not adequately enhance security but rounding to remove several digits of relative accuracy effectively reduced the risk of identification without substantially reducing utility. Grouping or adding random noise led to noticeable bias. Conclusions. When sharing epidemiologic data, it is recommended that masking be performed using rounding. Specific treatment should be determined separately in individual situations after consideration of the disclosure risks and analysis needs.

  8. Protecting Privacy of Shared Epidemiologic Data without Compromising Analysis Potential

    International Nuclear Information System (INIS)

    Cologne, J.; Nakashima, E.; Funamoto, S.; Grant, E.J.; Chen, Y.; Hiroaki Katayama, H.

    2012-01-01

    Objective. Ensuring privacy of research subjects when epidemiologic data are shared with outside collaborators involves masking (modifying) the data, but over masking can compromise utility (analysis potential). Methods of statistical disclosure control for protecting privacy may be impractical for individual researchers involved in small-scale collaborations. Methods. We investigated a simple approach based on measures of disclosure risk and analytical utility that are straightforward for epidemiologic researchers to derive. The method is illustrated using data from the Japanese Atomic-bomb Survivor population. Results. Masking by modest rounding did not adequately enhance security but rounding to remove several digits of relative accuracy effectively reduced the risk of identification without substantially reducing utility. Grouping or adding random noise led to noticeable bias. Conclusions. When sharing epidemiologic data, it is recommended that masking be performed using rounding. Specific treatment should be determined separately in individual situations after consideration of the disclosure risks and analysis needs

  9. Analysis of Petroleum Downstream Industry Potential in Riau Province

    Directory of Open Access Journals (Sweden)

    Tomi Erfando

    2017-06-01

    Full Text Available Petroleum downstream industry in Riau Province is still not optimal. The data shows that from 98,892,755 barrels lifting oil each year only 62,050,000 barrels could be processed in refinery unit II Dumai operated by PT Pertamina. There is a potential of 35-40% of downstream industry. Indonesian Government through The Ministry of Energy and Mineral Resources declared the construction of a mini refinery to boost oil processing output in the downstream sector. A feasibility study of development plan mini refinery is needed. The study includes production capacity analysis, product analysis, development & operational refinery  analysis and economic analysis. The results obtained by the mini refinery capacity is planned to process crude oil 6000 BOPD with the products produced are gasoline, kerosene, diesel and oil. Investment cost consist of is capital cost US $ 104419784 and operating cost US $ 13766734 each year with net profit earned US $ 12330063/year and rate of return from investment 11.63%

  10. Analysis of registered CDM projects: potential removal of evidenced bottlenecks

    Energy Technology Data Exchange (ETDEWEB)

    Agosto, D.; Bombard, P.; Gostinelli, F.

    2007-07-01

    The Clean Development Mechanism (CDM) has developed during its first period of implementation, a distinctive set of patterns. The authors thought of concentrating on the CDM analysis in order to highlight potential remedies or reasons for given bottlenecks. In order to establish a sort of extensive SWOT analysis for CDMs, all the 356 projects actually (November 2006) registered at UNFCCC were examined, together with all the about 1000 PDDs presented to the UNFCCC but not registered yet. The CDM projects have been studied trying to cluster projects according to relevant characteristics, both from a technical and an economic point of view. Chosen indicators are meant to identify: more convenient/more diffused energy system for a CDM; reasons for a geographical distribution of different types of projects; potentials for a future exploitation of lower used technologies in CDM. Conclusions are drawn and appropriate tables and graphs presented. (1) the Baseline Emission Factor, combined to economic patterns, is the pivotal factor that characterizes both choices of host country and technology; (2) some technologies can exploit appropriately CDM scheme, whilst other technologies, are constrained by it. (3) there are still some important weak points: grouping of non Annex I countries; crediting period; criteria for the evaluation of sustainable development. (auth)

  11. Wind energy potential analysis in Al-Fattaih-Darnah

    Energy Technology Data Exchange (ETDEWEB)

    Tjahjana, Dominicus Danardono Dwi Prija, E-mail: danar1405@gmail.com; Salem, Abdelkarim Ali, E-mail: keemsalem@gmail.com; Himawanto, Dwi Aries, E-mail: dwiarieshimawanto@gmail.com [University of Sebelas Maret, Jl. Ir. Sutami No. 36 A, Surakarta, Indonesia 57126 (Indonesia)

    2016-03-29

    In this paper the wind energy potential in Al-Fattaih-Darnah, Libya, had been studied. Wind energy is very attractive because it can provide a clean and renewable energy. Due mostly to the uncertainty caused by the chaotic characteristics of wind near the earth’s surface, wind energy characteristic need to be investigated carefully in order to get consistent power generation. This investigation was based on one year wind data measured in 2003. As a result of the analysis, wind speed profile and wind energy potential have been developed. The wind energy potential of the location is looked very promising to generate electricity. The annual wind speed of the site is 8.21 m/s and the wind speed carrying maximum energy is 7.97 m/s. The annual power density of the site is classified into class 3. The Polaris P50-500 wind turbine can produce 768.39 M Wh/year and has capacity factor of 17.54%.

  12. Analysis of some potential social effects of four coal technologies

    Energy Technology Data Exchange (ETDEWEB)

    Walker, C.A.; Gould, L.C.

    1980-09-01

    This is an analysis of the potential social impacts of four coal technologies: conventional combustion, fluidized-bed combustion, liquifaction, and gasification. Because of their flexibility, and the abundance and relatively low costs of coal, the potential benefits of these technologies would seem to outweigh their potential social costs, both in the intermediate and long term. Nevertheless, the social costs of a coal industry are far more obscure and hard to quantify than the benefits. In general, however, it maybe expected that those technologies that can be deployed most quickly, that provide fuels that can substitute most easily for oil and natural gas, that are the cheapest, and that are the most thermally efficient will minimize social costs most in the intermediate term, while technologies that can guide energy infrastructure changes to become the most compatable with the fuels that will be most easily derived from inexhaustible sources (electricity and hydrogen) will minimize social costs most in the long run. An industry structured to favor eastern over western coal and plant sites in moderate sized communities, which could easily adapt to inexhaustible energy technologies (nuclear or solar) in the future, would be favored in either time period.

  13. The Potential for Meta-Analysis to Support Decision Analysis in Ecology

    Science.gov (United States)

    Mengersen, Kerrie; MacNeil, M. Aaron; Caley, M. Julian

    2015-01-01

    Meta-analysis and decision analysis are underpinned by well-developed methods that are commonly applied to a variety of problems and disciplines. While these two fields have been closely linked in some disciplines such as medicine, comparatively little attention has been paid to the potential benefits of linking them in ecology, despite reasonable…

  14. Image seedling analysis to evaluate tomato seed physiological potential

    Directory of Open Access Journals (Sweden)

    Vanessa Neumann Silva

    Full Text Available Computerized seedling image analysis are one of the most recently techniques to detect differences of vigor between seed lots. The aim of this study was verify the hability of computerized seedling image analysis by SVIS® to detect differences of vigor between tomato seed lots as information provided by traditionally vigor tests. Ten lots of tomato seeds, cultivar Santa Clara, were stored for 12 months in controlled environment at 20 ± 1 ºC and 45-50% of relative humidity of the air. The moisture content of the seeds was monitored and the physiological potential tested at 0, 6 and 12 months after storage, with germination test, first count of germination, traditional accelerated ageing and with saturated salt solution, electrical conductivity, seedling emergence and with seed vigor imaging system (SVIS®. A completely randomized experimental design was used with four replications. The parameters obtained by the computerized seedling analysis (seedling length and indexes of vigor and seedling growth with software SVIS® are efficient to detect differences between tomato seed lots of high and low vigor.

  15. The multielement potential of fast neutron cyclic activation analysis

    International Nuclear Information System (INIS)

    Nonie, S.E.; Randle, K.

    1994-01-01

    Cyclic neutron activation analysis (CNAA) has, in recent years been developed as a useful analytical tool for the assay of short-lived isotopes in single element situations. The work described in this paper investigates the potential of the technique for composite samples having a wide range of elements that produce short-lived and long-lived isotopes on neutron irradiation. Accelerator-derived neutrons with average energies of 3 MeV, 6 MeV and 14 MeV were employed in what has been dubbed 'Fast Neutron Cyclic Neutron Activation Analysis' (FNCAA). The approach to multi-element analysis entailed: determination of cycle parameters in single element samples via the reactions 27 Al(n,p) 27 Mg(9.6 min,E γ =840keV), and 137 Ba(n,n 'γ137m Ba(2.3 min,E γ 137m Ba(2.3 min,E γ =662 keV), a test of the method on a composite rock sample, determination of analytical sensitivities using both powdered kale and rock standards and a comparison of analytical results with other techniques. The results obtained in all these measurements are presented and discussed. (author) 10 refs.; 3 figs.; 5 tabs

  16. ANALYSIS OF THE PERSONNEL POTENTIAL EFFICIENCY OF THE PHARMACEUTICAL INSTITUTION

    Directory of Open Access Journals (Sweden)

    Марина Юрьевна Клищенко

    2017-03-01

    The study revealed common patterns of the personnel potential efficiency of the pharmaceutical institution. It was found that pharmaceutical institutions need qualified professionals with a high level of practical training, ready to immediately join the working process. It was noted that only 47 % of graduates are prepared to work in the specialty chosen. We studied the length of employment with one employer. The analysis of the main problems making pharmaceutical professionals to change their work is performed. During the questioning of pharmaceutical students it was noted that a large number of students (32,89 % feel uncertainty about their further employment and 47 % of respondents are going to work in the profession.

  17. Preliminary analysis of biomass potentially useful for producing biodiesel

    International Nuclear Information System (INIS)

    Cabrera Cifuentes, Gerardo; Burbano Jaramillo, Juan Carlos; Garcia Melo, Jose Isidro

    2011-01-01

    Given that biodiesel is emerging as a viable solution for some energy and environmental problems, research on raw materials appropriate for its production is a matter of growing interest. In this study we present the results of research devoted to preliminary analysis on several vegetable (biomass) species potentially useful for producing biodiesel. The bioprospection zone is a region on the Colombian Pacific coast. The candidate species collected underwent different standardized ASTM tests in order for us to define properties that facilitate their evaluation. Some of the species underwent a transesterification process. Comparisons between the thermo-physical properties of the biofuels obtained and the properties of commercial diesel were carried out. Also, performance tests for these biofuels were conducted in compression ignition engines, particularly evaluating efficiency, fuel consumption, and potency at different RPMs.

  18. High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hanna; Park, Minhee; Shin, Nara; Kim, Gamin [Department of Pathology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul (Korea, Republic of); Kim, Yun Gi [Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744 (Korea, Republic of); Shin, Jeon-Soo [Department of Microbiology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul (Korea, Republic of); Kim, Hoguen, E-mail: hkyonsei@yuhs.ac [Department of Pathology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul (Korea, Republic of)

    2012-07-27

    Highlights: Black-Right-Pointing-Pointer Specific enzyme for HMGB1 phosphorylation and its secretion is proposed. Black-Right-Pointing-Pointer Inhibition of PKC-{zeta} leads to significant reduction of the secreted HMGB1. Black-Right-Pointing-Pointer Phosphorylation of specific site of HMGB1 redirects its secretion in cancer cells. Black-Right-Pointing-Pointer Activation of PKC-{zeta} in cancers explains the enhanced HMGB1 secretion. -- Abstract: High mobility group box-1 (HMGB1), a nuclear protein, is overexpressed and secreted in cancer cells. Phosphorylation on two different nuclear localization signal regions are known to be important for the nuclear-to-cytoplasmic transport and secretion of HMGB1. However, little is known about the biochemical mechanism of HMGB1 modifications and its subsequent secretion from cancer cells. To identify the specific enzyme and important sites for HMGB1 phosphorylation, we screened the protein kinase C (PKC) family in a colon cancer cell line (HCT116) for HMGB1 binding by pull-down experiments using a 3XFLAG-HMGB1 construct. Strong interactions between atypical PKCs (PKC-{zeta}, {lambda}, and {iota}) and cytoplasmic HMGB1 were observed in HCT116 cells. We further identified the most critical PKC isotype that regulates HMGB1 secretion is PKC-{zeta} by using PKC inhibitors and siRNA experiments. The serine residues at S39, S53 and S181 of HMGB1 were related to enhancing HMGB1 secretion. We also demonstrated overexpression and activation of PKC-{zeta} in colon cancer tissues. Our findings suggest that PKC-{zeta} is involved in the phosphorylation of HMGB1, and the phosphorylation of specific serine residues in the nuclear localization signal regions is related to enhanced HMGB1 secretion in colon cancer cells.

  19. Potential of isotope analysis (C, Cl) to identify dechlorination mechanisms

    Science.gov (United States)

    Cretnik, Stefan; Thoreson, Kristen; Bernstein, Anat; Ebert, Karin; Buchner, Daniel; Laskov, Christine; Haderlein, Stefan; Shouakar-Stash, Orfan; Kliegman, Sarah; McNeill, Kristopher; Elsner, Martin

    2013-04-01

    Chloroethenes are commonly used in industrial applications, and detected as carcinogenic contaminants in the environment. Their dehalogenation is of environmental importance in remediation processes. However, a detailed understanding frequently accounted problem is the accumulation of toxic degradation products such as cis-dichloroethylene (cis-DCE) at contaminated sites. Several studies have addressed the reductive dehalogenation reactions using biotic and abiotic model systems, but a crucial question in this context has remained open: Do environmental transformations occur by the same mechanism as in their corresponding in vitro model systems? The presented study shows the potential to close this research gap using the latest developments in compound specific chlorine isotope analysis, which make it possible to routinely measure chlorine isotope fractionation of chloroethenes in environmental samples and complex reaction mixtures.1,2 In particular, such chlorine isotope analysis enables the measurement of isotope fractionation for two elements (i.e., C and Cl) in chloroethenes. When isotope values of both elements are plotted against each other, different slopes reflect different underlying mechanisms and are remarkably insensitive towards masking. Our results suggest that different microbial strains (G. lovleyi strain SZ, D. hafniense Y51) and the isolated cofactor cobalamin employ similar mechanisms of reductive dechlorination of TCE. In contrast, evidence for a different mechanism was obtained with cobaloxime cautioning its use as a model for biodegradation. The study shows the potential of the dual isotope approach as a tool to directly compare transformation mechanisms of environmental scenarios, biotic transformations, and their putative chemical lab scale systems. Furthermore, it serves as an essential reference when using the dual isotope approach to assess the fate of chlorinated compounds in the environment.

  20. Dynamical zeta functions and dynamical determinants for hyperbolic maps a functional approach

    CERN Document Server

    Baladi, Viviane

    2018-01-01

    The spectra of transfer operators associated to dynamical systems, when acting on suitable Banach spaces, contain key information about the ergodic properties of the systems. Focusing on expanding and hyperbolic maps, this book gives a self-contained account on the relation between zeroes of dynamical determinants, poles of dynamical zeta functions, and the discrete spectra of the transfer operators. In the hyperbolic case, the first key step consists in constructing a suitable Banach space of anisotropic distributions. The first part of the book is devoted to the easier case of expanding endomorphisms, showing how the (isotropic) function spaces relevant there can be studied via Paley–Littlewood decompositions, and allowing easier access to the construction of the anisotropic spaces which is performed in the second part. This is the first book describing the use of anisotropic spaces in dynamics. Aimed at researchers and graduate students, it presents results and techniques developed since the beginning of...

  1. Relations between elliptic multiple zeta values and a special derivation algebra

    International Nuclear Information System (INIS)

    Broedel, Johannes; Matthes, Nils; Schlotterer, Oliver

    2016-01-01

    We investigate relations between elliptic multiple zeta values (eMZVs) and describe a method to derive the number of indecomposable elements of given weight and length. Our method is based on representing eMZVs as iterated integrals over Eisenstein series and exploiting the connection with a special derivation algebra. Its commutator relations give rise to constraints on the iterated integrals over Eisenstein series relevant for eMZVs and thereby allow to count the indecomposable representatives. Conversely, the above connection suggests apparently new relations in the derivation algebra. Under https://tools.aei.mpg.de/emzv we provide relations for eMZVs over a wide range of weights and lengths. (paper)

  2. Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A

    Directory of Open Access Journals (Sweden)

    William D. Cornwell

    2010-06-01

    Full Text Available Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy. We characterized the components of the T cell receptor (TCR during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.

  3. Space-frequency analysis and reduction of potential field ambiguity

    Directory of Open Access Journals (Sweden)

    A. Rapolla

    1997-06-01

    Full Text Available Ambiguity of depth estimation of magnetic sources via spectral analysis can be reduced representing its field via a set of space-frequency atoms. This is obtained throughout a continuous wavelet transform using a Morlet analyzing wavelet. In the phase-plane representation even a weak contribution related to deep-seated sources is clearly distinguished with respect a more intense effect of a shallow source, also in the presence of a strong noise. Furthermore, a new concept of local power spectrum allows the depth to both the sources to be correctly interpreted. Neither result can be provided by standard Fourier analysis. Another method is proposed to reduce ambiguity by inversion of potential field data lying along the vertical axis. This method allows a depth resolution to gravity or the magnetic methods and below some conditions helps to reduce their inherent ambiguity. Unlike the case of monopoles, inversion of a vertical profile of gravity data above a cubic source gives correct results for the cube side and density.

  4. Streaming potential near a rotating porous disk.

    Science.gov (United States)

    Prieve, Dennis C; Sides, Paul J

    2014-09-23

    Theory and experimental results for the streaming potential measured in the vicinity of a rotating porous disk-shaped sample are described. Rotation of the sample on its axis draws liquid into its face and casts it from the periphery. Advection within the sample engenders streaming current and streaming potential that are proportional to the zeta potential and the disk's major dimensions. When Darcy's law applies, the streaming potential is proportional to the square of the rotation at low rate but becomes invariant with rotation at high rate. The streaming potential is invariant with the sample's permeability at low rate and is proportional to the inverse square of the permeability at high rate. These predictions were tested by determining the zeta potential and permeability of the loop side of Velcro, a sample otherwise difficult to characterize; reasonable values of -56 mV for zeta and 8.7 × 10(-9) m(2) for the permeability were obtained. This approach offers the ability to determine both the zeta potential and the permeability of materials having open structures. Compressing them into a porous plug is unnecessary. As part of the development of the theory, a convenient formula for a flow-weighted volume-averaged space-charge density of the porous medium, -εζ/k, was obtained, where ε is the permittivity, ζ is the zeta potential, and k is the Darcy permeability. The formula is correct when Smoluchowski's equation and Darcy's law are both valid.

  5. Analysis of Hydropower Potential Utilization of Watercourses in Slovakia

    Science.gov (United States)

    Gejguš, Mirko; Aschbacher, Christine; Sablik, Jozef

    2017-09-01

    This article analyzes the hydropower potential of watercourses in Slovakia, defining water as the most promising and most used renewable energy source. The hydro-energetic potential as a source of energy is determined by the calculation of the technically feasible potential of the watercourses, which is divided into exploited and unused. It also identifies the potential of utilizing the unused technical hydro-energetic potential.

  6. Chemical analysis and potential health risks of hookah charcoal

    Energy Technology Data Exchange (ETDEWEB)

    Elsayed, Yehya, E-mail: yelsayed@aus.edu; Dalibalta, Sarah, E-mail: sdalibalta@aus.edu; Abu-Farha, Nedal

    2016-11-01

    Hookah (waterpipe) smoking is a very common practice that has spread globally. There is growing evidence on the hazardous consequences of smoking hookah, with studies indicating that its harmful effects are comparable to cigarette smoking if not worse. Charcoal is commonly used as a heating source for hookah smoke. Although charcoal briquettes are thought to be one of the major contributors to toxicity, their composition and impact on the smoke generated remains largely unidentified. This study aims to analyze the elemental composition of five different raw synthetic and natural charcoals by using Carbon-Hydrogen-Nitrogen (CHN) analysis, inductively coupled plasma (ICP), and scanning electron microscopy coupled with energy dispersive X-Ray spectrometry (SEM-EDS). Elemental analysis showed that the raw charcoals contain heavy metals such as zinc, iron, cadmium, vanadium, aluminum, lead, chromium, manganese and cobalt at concentrations similar, if not higher than, cigarettes. In addition, thermal desorption-gas chromatography–mass spectrometry (TD-GC–MS) was used to analyze the chemical composition of the smoke produced from burning the charcoal samples. The smoke emitted from charcoal was found to be the source of numerous compounds which could be hazardous to health. A total of seven carcinogens, 39 central nervous system depressants and 31 respiratory irritants were identified. - Highlights: • Hookah charcoals, mainly synthetic brands, contains trace/heavy metals in concentrations exceeding those in cigarettes. • The concentration of lead in synthetic charcoal briquettes may impose adverse effects on human health. • The amount of nitrogen in synthetic charcoal is comparable to that reported in cigarettes. • Chemical profiling of smoke emitted from hookah charcoal reveals many compounds associated with potential health risks.

  7. Chemical analysis and potential health risks of hookah charcoal

    International Nuclear Information System (INIS)

    Elsayed, Yehya; Dalibalta, Sarah; Abu-Farha, Nedal

    2016-01-01

    Hookah (waterpipe) smoking is a very common practice that has spread globally. There is growing evidence on the hazardous consequences of smoking hookah, with studies indicating that its harmful effects are comparable to cigarette smoking if not worse. Charcoal is commonly used as a heating source for hookah smoke. Although charcoal briquettes are thought to be one of the major contributors to toxicity, their composition and impact on the smoke generated remains largely unidentified. This study aims to analyze the elemental composition of five different raw synthetic and natural charcoals by using Carbon-Hydrogen-Nitrogen (CHN) analysis, inductively coupled plasma (ICP), and scanning electron microscopy coupled with energy dispersive X-Ray spectrometry (SEM-EDS). Elemental analysis showed that the raw charcoals contain heavy metals such as zinc, iron, cadmium, vanadium, aluminum, lead, chromium, manganese and cobalt at concentrations similar, if not higher than, cigarettes. In addition, thermal desorption-gas chromatography–mass spectrometry (TD-GC–MS) was used to analyze the chemical composition of the smoke produced from burning the charcoal samples. The smoke emitted from charcoal was found to be the source of numerous compounds which could be hazardous to health. A total of seven carcinogens, 39 central nervous system depressants and 31 respiratory irritants were identified. - Highlights: • Hookah charcoals, mainly synthetic brands, contains trace/heavy metals in concentrations exceeding those in cigarettes. • The concentration of lead in synthetic charcoal briquettes may impose adverse effects on human health. • The amount of nitrogen in synthetic charcoal is comparable to that reported in cigarettes. • Chemical profiling of smoke emitted from hookah charcoal reveals many compounds associated with potential health risks.

  8. Redirecting Therapeutic T Cells against Myelin-Specific T Lymphocytes Using a Humanized Myelin Basic Protein-HLA-DR2-{zeta} Chimeric Receptor

    DEFF Research Database (Denmark)

    Moisini, Ioana; Nguyen, Phuong; Fugger, Lars

    2008-01-01

    Therapies that Ag-specifically target pathologic T lymphocytes responsible for multiple sclerosis (MS) and other autoimmune diseases would be expected to have improved therapeutic indices compared with Ag-nonspecific therapies. We have developed a cellular immunotherapy that uses chimeric receptors...... mouse model system. Finally, the chimeric receptor-modified CTL ameliorated or blocked experimental allergic encephalomyelitis (EAE) disease mediated by MBP(84-102)/DR2-specific T lymphocytes. These results provide support for the further development of redirected therapeutic T cells able to counteract...... pathologic, self-specific T lymphocytes, and specifically validate humanized MBP-DR2-zeta chimeric receptors as a potential therapeutic in MS. Udgivelsesdato: 2008-Mar-1...

  9. High resolution melting (HRM) analysis of DNA--its role and potential in food analysis.

    Science.gov (United States)

    Druml, Barbara; Cichna-Markl, Margit

    2014-09-01

    DNA based methods play an increasing role in food safety control and food adulteration detection. Recent papers show that high resolution melting (HRM) analysis is an interesting approach. It involves amplification of the target of interest in the presence of a saturation dye by the polymerase chain reaction (PCR) and subsequent melting of the amplicons by gradually increasing the temperature. Since the melting profile depends on the GC content, length, sequence and strand complementarity of the product, HRM analysis is highly suitable for the detection of single-base variants and small insertions or deletions. The review gives an introduction into HRM analysis, covers important aspects in the development of an HRM analysis method and describes how HRM data are analysed and interpreted. Then we discuss the potential of HRM analysis based methods in food analysis, i.e. for the identification of closely related species and cultivars and the identification of pathogenic microorganisms. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Pressure potential and stability analysis in an acoustical noncontact transportation

    Science.gov (United States)

    Li, J.; Liu, C. J.; Zhang, W. J.

    2017-01-01

    Near field acoustic traveling wave is one of the most popular principles in noncontact manipulations and transportations. The stability behavior is a key factor in the industrial applications of acoustical noncontact transportation. We present here an in-depth analysis of the transportation stability of a planar object levitated in near field acoustic traveling waves. To more accurately describe the pressure distributions on the radiation surface, a 3D nonlinear traveling wave model is presented. A closed form solution is derived based on the pressure potential to quantitatively calculate the restoring forces and moments under small disturbances. The physical explanations of the effects of fluid inertia and the effects of non-uniform pressure distributions are provided in detail. It is found that a vibration rail with tapered cross section provides more stable transportation than a rail with rectangular cross section. The present study sheds light on the issue of quantitative evaluation of stability in acoustic traveling waves and proposes three main factors that influence the stability: (a) vibration shape, (b) pressure distribution and (c) restoring force/moment. It helps to provide a better understanding of the physics behind the near field acoustic transportation and provide useful design and optimization tools for industrial applications.

  11. Igusa's $p$-Adic local zeta function and the monodromy conjecture for non-degenerate surface singularities

    CERN Document Server

    Bories, Bart

    2016-01-01

    In 2011 Lemahieu and Van Proeyen proved the Monodromy Conjecture for the local topological zeta function of a non-degenerate surface singularity. The authors start from their work and obtain the same result for Igusa's p-adic and the motivic zeta function. In the p-adic case, this is, for a polynomial f\\in\\mathbf{Z}[x,y,z] satisfying f(0,0,0)=0 and non-degenerate with respect to its Newton polyhedron, we show that every pole of the local p-adic zeta function of f induces an eigenvalue of the local monodromy of f at some point of f^{-1}(0)\\subset\\mathbf{C}^3 close to the origin. Essentially the entire paper is dedicated to proving that, for f as above, certain candidate poles of Igusa's p-adic zeta function of f, arising from so-called B_1-facets of the Newton polyhedron of f, are actually not poles. This turns out to be much harder than in the topological setting. The combinatorial proof is preceded by a study of the integral points in three-dimensional fundamental parallelepipeds. Together with the work of L...

  12. Analysis of the Components of Economic Potential of Agricultural Enterprises

    OpenAIRE

    Vyacheslav Skobara; Volodymyr Podkopaev

    2014-01-01

    Problems of efficiency of enterprises are increasingly associated with the use of the economic potential of the company. This article addresses the structural components of the economic potential of agricultural enterprise, development and substantiation of the model of economic potential with due account of the peculiarities of agricultural production. Based on the study of various approaches to the potential structure established is the definition of of production, labour, financial and man...

  13. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors.

    Science.gov (United States)

    Braren, Stephen H; Drapala, Damian; Tulloch, Ingrid K; Serrano, Peter A

    2014-01-01

    Methamphetamine (MA) is a toxic, addictive drug shown to modulate learning and memory, yet the neural mechanisms are not fully understood. We investigated the effects of 2 weekly injections of MA (30 mg/kg) on working memory using the radial 8-arm maze (RAM) across 5 weeks in adolescent-age mice. MA-treated mice show a significant improvement in working memory performance 1 week following the first MA injection compared to saline-injected controls. Following 5 weeks of MA abstinence mice were re-trained on a reference and working memory version of the RAM to assess cognitive flexibility. MA-treated mice show significantly more working memory errors without effects on reference memory performance. The hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, GluA2 and GluN2B; dopamine markers, dopamine 1 receptor (D1), dopamine transporter (DAT) and tyrosine hydroxylase (TH); and memory markers, protein kinase M zeta (PKMζ) and protein kinase C zeta (PKCζ). Within the hippocampus, PKMζ and GluA2 are both significantly reduced after MA supporting the poor memory performance. Additionally, a significant increase in GluN2B and decrease in D1 identifies dysregulated synaptic function. In the striatum, MA treatment increased cytosolic DAT and TH levels associated with dopamine hyperfunction. MA treatment significantly reduced GluN2B while increasing both PKMζ and PKCζ within the striatum. We discuss the potential role of PKMζ/PKCζ in modulating dopamine and glutamate receptors after MA treatment. These results identify potential underlying mechanisms for working memory deficits induced by MA.

  14. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects Protein Kinase M zeta (PKMζ, dopamine, and glutamate receptors

    Directory of Open Access Journals (Sweden)

    Stephen H Braren

    2014-12-01

    Full Text Available Methamphetamine (MA is a toxic, addictive drug shown to modulate learning and memory, yet the neural mechanisms are not fully understood. We investigated the effects of 2 weekly injections of MA (30 mg/kg on working memory using the radial 8-arm maze (RAM across 5 weeks in adolescent-age mice. MA-treated mice show a significant improvement in working memory performance 1 week following the first MA injection compared to saline-injected controls. Following 5 weeks of MA abstinence mice were re-trained on a reference and working memory version of the RAM to assess cognitive flexibility. MA-treated mice show significantly more working memory errors without effects on reference memory performance. The hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, GluA2 and GluN2B; dopamine markers, dopamine 1 receptor (D1, dopamine transporter (DAT and tyrosine hydroxylase (TH; and memory markers, protein kinase M zeta (PKMζ and protein kinase C zeta (PKCζ. Within the hippocampus, PKMζ and GluA2 are both significantly reduced after MA supporting the poor memory performance. Additionally, a significant increase in GluN2B and decrease in D1 identifies dysregulated synaptic function. In the striatum, MA treatment increased cytosolic DAT and TH levels associated with dopamine hyperfunction. MA treatment significantly reduced GluN2B while increasing both PKMζ and PKCζ within the striatum. We discuss the potential role of PKMζ/PKCζ in modulating dopamine and glutamate receptors after MA treatment. These results identify potential underlying mechanisms for working memory deficits induced by MA.

  15. Revenue potential, tax space, and tax gap : a comparative analysis

    OpenAIRE

    Khwaja, Munawer Sultan; Iyer, Indira

    2014-01-01

    This paper contributes to the empirical literature on the key determinants of the revenue generating potential in 61 countries. The paper uses a broad set of data and econometric methods to conduct analyses that are of relevance to revenue potential. Earlier studies have not distinguished between the revenue potential based on economic fundamentals of countries and that based on what the l...

  16. The potential for meta-analysis to support decision analysis in ecology.

    Science.gov (United States)

    Mengersen, Kerrie; MacNeil, M Aaron; Caley, M Julian

    2015-06-01

    Meta-analysis and decision analysis are underpinned by well-developed methods that are commonly applied to a variety of problems and disciplines. While these two fields have been closely linked in some disciplines such as medicine, comparatively little attention has been paid to the potential benefits of linking them in ecology, despite reasonable expectations that benefits would be derived from doing so. Meta-analysis combines information from multiple studies to provide more accurate parameter estimates and to reduce the uncertainty surrounding them. Decision analysis involves selecting among alternative choices using statistical information that helps to shed light on the uncertainties involved. By linking meta-analysis to decision analysis, improved decisions can be made, with quantification of the costs and benefits of alternate decisions supported by a greater density of information. Here, we briefly review concepts of both meta-analysis and decision analysis, illustrating the natural linkage between them and the benefits from explicitly linking one to the other. We discuss some examples in which this linkage has been exploited in the medical arena and how improvements in precision and reduction of structural uncertainty inherent in a meta-analysis can provide substantive improvements to decision analysis outcomes by reducing uncertainty in expected loss and maximising information from across studies. We then argue that these significant benefits could be translated to ecology, in particular to the problem of making optimal ecological decisions in the face of uncertainty. Copyright © 2013 John Wiley & Sons, Ltd.

  17. On the issue of the {zeta} series convergence and loop corrections in the generation of observable primordial non-Gaussianity in slow-roll inflation: I. The bispectrum

    Energy Technology Data Exchange (ETDEWEB)

    Cogollo, Heiner R S; Rodriguez, Yeinzon; Valenzuela-Toledo, Cesar A, E-mail: heiner.sarmiento@ciencias.uis.edu.co, E-mail: yeinzon.rodriguez@uan.edu.co, E-mail: cavalto@ciencias.uis.edu.co [Escuela de Fisica, Universidad Industrial de Santander, Ciudad Universitaria, Bucaramanga (Colombia)

    2008-08-15

    We show in this paper that it is possible to attain very high, including observable, values for the level of non-Gaussianity f{sub NL} associated with the bispectrum B{sub {zeta}} of the primordial curvature perturbation {zeta}, in a subclass of small-field slow-roll models of inflation with canonical kinetic terms. Such a result is obtained by taking care of loop corrections both in the spectrum P{sub {zeta}} and in the bispectrum B{sub {zeta}}. Sizable values for f{sub NL} arise even if {zeta} is generated during inflation. Five issues are considered when constraining the available parameter space: (1) We must ensure that we are in a perturbative regime so that the {zeta} series expansion, and its truncation, are valid. (2) We must apply the correct condition for the (possible) loop dominance in B{sub {zeta}} and/or P{sub {zeta}}. (3) We must satisfy the spectrum normalization condition. (4) We must satisfy the spectral tilt constraint. (5) We must have enough inflation to solve the horizon problem.

  18. Quantification of elemental segregation to lath and grain boundaries in low-alloy steel by STEM X-ray mapping combined with the zeta-factor method

    CERN Document Server

    Watanabe, M

    2003-01-01

    Elemental segregation to two types of boundaries in a low-alloy steel were studied by X-ray mapping using scanning transmission electron microscopy (STEM). To quantify the acquired X-ray maps, the zeta-factor method was applied, and then the compositional maps and the thickness map were obtained. Based on these quantified maps, further information about the analytical sensitivity of solute-element detection and the spatial resolution of segregation analysis were extracted. Furthermore, maps of the number of excess atoms on the boundary were also calculated from the compositional and thickness maps. It was concluded that Cr, Ni and Mo are co-segregated on the prior-austenite grain boundary and only Ni was segregated on the lath boundary. (orig.)

  19. Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development

    International Nuclear Information System (INIS)

    Sone, Yoshie; Ito, Masahiko; Shirakawa, Hideki; Shikano, Tomohide; Takeuchi, Hiroyuki; Kinoshita, Katsuyuki; Miyazaki, Shunichi

    2005-01-01

    Phospholipase C-zeta (PLCζ), a strong candidate of the egg-activating sperm factor, causes intracellular Ca 2+ oscillations and egg activation, and is subsequently accumulated into the pronucleus (PN), when expressed in mouse eggs by injection of RNA encoding PLCζ. Changes in the localization of expressed PLCζ were investigated by tagging with a fluorescent protein. PLCζ began to translocate into the PN formed at 5-6 h after RNA injection and increased there. Observation in the same embryo revealed that PLCζ in the PN dispersed to the cytoplasm upon nuclear envelope breakdown and translocated again into the nucleus after cleavage. The dynamics was found in the second mitosis as well. When RNA was injected into fertilization-originated 1-cell embryos or blastomere(s) of 2-8-cell embryos, the nuclear localization of expressed PLCζ was recognized in every embryo up to blastocyst. Thus, PLCζ exhibited alternative cytoplasm/nucleus localization during development. This supports the view that the sperm factor could control cell cycle-dependent generation of Ca 2+ oscillations in early embryogenesis

  20. Multiple zeta functions and double wrapping in planar N=4 SYM

    Science.gov (United States)

    Leurent, Sébastien; Volin, Dmytro

    2013-10-01

    Using the FiNLIE solution of the AdS/CFT Y-system, we compute the anomalous dimension of the Konishi operator in planar N=4 SYM up to eight loops, i.e. up to the leading double wrapping order. At this order a non-reducible Euler-Zagier sum, ζ1,2,8, appears for the first time. We find that at all orders in perturbation, every spectral-dependent quantity of the Y-system is expressed through multiple Hurwitz zeta functions, hence we provide a Mathematica package to manipulate these functions, including the particular case of Euler-Zagier sums. Furthermore, we conjecture that only Euler-Zagier sums can appear in the answer for the anomalous dimension at any order in perturbation theory. We also resum the leading transcendentality terms of the anomalous dimension at all orders, obtaining a simple result in terms of Bessel functions. Finally, we demonstrate that exact Bethe equations should be related to an absence of poles condition that becomes especially non-trivial at double wrapping.

  1. Perancangan Zeta Converter yang dilengkapi Power Factor Correction pada Aplikasi Pengaturan Kecepatan Motor Brushless DC

    Directory of Open Access Journals (Sweden)

    Adhika Prajna Nandiwardhana

    2017-01-01

    Full Text Available Penggunaan motor brushless DC telah banyak digunakan dalam berbagai bidang seperti peralatan rumah tangga maupun industri dikarenakan motor ini memiliki struktur yang sederhana, efisiensi dan torsi yang tinggi, serta menggunakan konsep komutasi elektris yang berbeda dari motor DC lainnya. Namun pengoperasian pada umumnya yang menggunakan sumber AC, penyearah serta inverter membuat tingginya nilai harmonisa arus (THD sebesar 73,33% dan power factor sebesar 0,803 dimana nilai ini kurang baik dalam pengaplikasiannya. Pada penelitian ini akan dikaji mengenai proses power factor correction yang mereduksi harmonisa arus (THD sumber AC dengan menggunakan zeta converter dalam pengaplikasian motor brushless DC, serta pengoperasian motor dengan mengamati respon motor terhadap kecepatan referensi yang berubah-ubah dan mengamati kestabilan motor terhadap pembebanan yang bervariasi. Dalam menerapkan metode yang dilakukan pada penelitian ini, pengoperasian motor brushless DC yang telah dirancang dapat bekerja dengan baik meliputi respon motor yang dapat mengikuti kecepatan referensi yang berubah-ubah, serta kestabilan motor dalam mempertahankan kecepatannya pada pembebanan yang bervariasi. Proses power factor correction dapat meningkatkan kualitas daya pada berbagai kecepatan dan mode penerapan yang berbeda-beda, dimana peningkatan tersebut membuktikan kinerja yang baik dalam sistem ini dan memiliki nilai kualitas daya yang baik.

  2. Tc Trends and Terrestrial Planet Formation: The Case of Zeta Reticuli

    Science.gov (United States)

    Adibekyan, Vardan; Delgado-Mena, Elisa; Figueira, Pedro; Sousa, Sergio; Santos, Nuno; Faria, Joao; González Hernández, Jonay; Israelian, Garik; Harutyunyan, Gohar; Suárez-Andrés, Lucia; Hakobyan, Artur

    2016-11-01

    During the last decade astronomers have been trying to search for chemical signatures of terrestrial planet formation in the atmospheres of the hosting stars. Several studies suggested that the chemical abundance trend with the condensation temperature, Tc, is a signature of rocky planet formation. In particular, it was suggested that the Sun shows 'peculiar' chemical abundances due to the presence of the terrestrial planets in our solar-system. However, the rocky material accretion or the trap of rocky materials in terrestrial planets is not the only explanation for the chemical 'peculiarity' of the Sun, or other Sun-like stars with planets. In this talk I madea very brief review of this topic, and presented our last results for the particular case of Zeta Reticuli binary system: A very interesting and well-known system (known in science fiction and ufology as the world of Grey Aliens, or Reticulans) where one of the components hosts an exo-Kuiper belt, and the other component is a 'single', 'lonely' star.

  3. Giants of eclipse the ζ [Zeta] Aurigae stars and other binary systems

    CERN Document Server

    Griffin, Elizabeth

    2015-01-01

    The zeta Aurigae stars are the rare but illustrious sub-group of binary stars that undergo the dramatic phenomenon of "chromospheric eclipse". This book provides detailed descriptions of the ten known systems, illustrates them richly with examples of new spectra, and places them in the context of stellar structure and evolution. Comprised of a large cool giant plus a small hot dwarf, these key eclipsing binaries reveal fascinating changes in their spectra very close to total eclipse, when the hot star shines through differing heights of the "chromosphere", or outer atmosphere, of the giant star. The phenomenon provides astrophysics with the means of analyzing the outer atmosphere of a giant star and how that material is shed into space. The physics of these critical events can be explained qualitatively, but it is more challenging to extract hard facts from the observations, and tough to model the chromosphere in any detail. The book offers current thinking on mechanisms for heating a star's chromosphere an...

  4. Analysis of phenomenological potentials for a quarkonium-like system

    International Nuclear Information System (INIS)

    Carvalho, H.F. de; Chanda, R.

    1979-01-01

    The comparison is made of the numerical results of quark-antiquark bound state spectra in a non-relativistic approximation for interaction effective potentials. The discussion of several aspects attached to the scalar and vetor nature of the confinant potential is made. The results obtained are compared with recent data on the PSI family. (L.C.) [pt

  5. An analysis of pipe degradation shape using potential drop method

    International Nuclear Information System (INIS)

    Jegal, S.; Lee, S. H.

    1999-01-01

    The Potential Drop (PD) method, one of NDE (Non-Destructive Evaluation) method is used to analyze the thickness distribution of pipes degraded by FAC (Flow Accelerated Corrosion). A DCPD (Direct Current Potential Drop) system which can measure PD for direct current was made, and the specimens with line defects and cylinder type defects have been used for experiments to prove the theory of Potential Drop method and to find out the effects of each factors. The experiment to find out defect distributions has been performed and it is found that PD method can analyze almost correct position of defects

  6. Accuracy of Protein Embedding Potentials: An Analysis in Terms of Electrostatic Potentials

    DEFF Research Database (Denmark)

    Olsen, Jogvan Magnus Haugaard; List, Nanna Holmgaard; Kristensen, Kasper

    2015-01-01

    strategies combined with single-fragment ab initio calculations. In fact, due to the self-interaction error in Kohn–Sham density functional theory (KS-DFT), use of large full-structure quantum-mechanical calculations based on conventional (hybrid) functionals leads to less accurate embedding potentials than...

  7. Analysis of relationship among visual evoked potential, oscillatory potential and visual acuity under stimulated weightlessness

    Directory of Open Access Journals (Sweden)

    Jun Zhao

    2013-05-01

    Full Text Available AIM: To observe the influence of head-down tilt simulated weightlessness on visual evoked potential(VEP, oscillatory potentials(OPsand visual acuity, and analyse the relationship among them. METHODS: Head-down tilt for -6° was adopted in 14 healthy volunteers. Distant visual acuity, near visual acuity, VEP and OPs were recorded before, two days and five days after trial. The record procedure of OPs followed the ISCEV standard for full-field clinical electroretinography(2008 update. RESULTS: Significant differences were detected in the amplitude of P100 waves and ∑OPs among various time points(P<0.05. But no relationship was observed among VEP, OPs and visual acuity. CONCLUSION: Head-down tilt simulated weightlessness induce the rearrange of blood of the whole body including eyes, which can make the change of visual electrophysiology but not visual acuity.

  8. Building-integrated PV -- Analysis and US market potential

    International Nuclear Information System (INIS)

    Frantzis, L.; Hill, S.; Teagan, P.; Friedman, D.

    1994-01-01

    Arthur D Little, Inc., in conjunction with Solar Design Associates, conducted a study for the US Department of Energy (DOE), Office of Building Technologies (OBT) to determine the market potential for building-integrated photovoltaics (BIPV). This study defines BIPV as two types of applications: (1) where the PV modules are an integral part of the building, often serving as the exterior weathering skin, and (2) the PV modules are mounted on the existing building exterior. Both of these systems are fully integrated with the energy usage of the building and have potential for significant market penetration in the US

  9. First Generation College Student Leadership Potential: A Mixed Methods Analysis

    Science.gov (United States)

    Hojan-Clark, Jane M.

    2010-01-01

    This mixed methods research compared the leadership potential of traditionally aged first generation college students to that of college students whose parents are college educated. A college education provides advantages to those who can obtain it (Baum & Payea, 2004; Black Issues in Higher Education, 2005; Education and the Value of…

  10. Brief analysis on uranium metallogenic potential in Wunikeng area

    International Nuclear Information System (INIS)

    Wang Binghua

    2010-01-01

    Through the geological mapping, gamma total equivalent weight survey in Wunikeng area, the tectonics and gamma anomalies discovered in this area are analyzed, uranium metallogenic potential is analyzed by combining the regional metallogenic condition, contrasting the metallogenic geological background, massif condition, tectonic framework from these aspects of the regional geological background, massif condition on the work area, tectonic framework, etc.. (authors)

  11. Geospatial Analysis of Renewable Energy Technical Potential on Tribal Lands

    Energy Technology Data Exchange (ETDEWEB)

    Doris, E.; Lopez, A.; Beckley, D.

    2013-02-01

    This technical report uses an established geospatial methodology to estimate the technical potential for renewable energy on tribal lands for the purpose of allowing Tribes to prioritize the development of renewable energy resources either for community scale on-tribal land use or for revenue generating electricity sales.

  12. Quantum chemical analysis of potential anti-Parkinson agents

    Indian Academy of Sciences (India)

    Intermolecular binding energy components could not be analyzed by docking and due to this .... Cluster analysis was performed on the docked results with regard to RMS ... gard, docking simulation is a key tool in structural mo- lecular biology ...

  13. Epoetin zeta in the management of anemia associated with chronic kidney disease, differential pharmacology and clinical utility

    Directory of Open Access Journals (Sweden)

    Davis-Ajami ML

    2014-04-01

    Full Text Available Mary Lynn Davis-Ajami,1 Jun Wu,2 Katherine Downton,3 Emilie Ludeman,3 Virginia Noxon4 1Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, MD, USA; 2South Carolina College of Pharmacy, University of South Carolina, Greenville, SC, USA; 3Health Sciences and Human Services Library, University of Maryland, Baltimore, MD, USA; 4Department of Clinical Pharmacy and Outcomes Science, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA Abstract: Epoetin zeta was granted marketing authorization in October 2007 by the European Medicines Agency as a recombinant human erythropoietin erythropoiesis-stimulating agent to treat symptomatic anemia of renal origin in adult and pediatric patients on hemodialysis and adults on peritoneal dialysis, as well as for symptomatic renal anemia in adult patients with renal insufficiency not yet on dialysis. Currently, epoetin zeta can be administered either subcutaneously or intravenously to correct for hemoglobin concentrations ≤10 g/dL (6.2 mmol/L or with dose adjustment to maintain hemoglobin levels at desired levels not in excess of 12 g/dL (7.5 mmol/L. This review article focuses on epoetin zeta indications in chronic kidney disease, its use in managing anemia of renal origin, and discusses its pharmacology and clinical utility. Keywords: biosimilar, chronic kidney disease, epoetin alfa, erythropoiesis, renal anemia, Retacrit®

  14. Investigation on Fuzzy Logic Based Centralized Control in Four-Port SEPIC/ZETA Bidirectional Converter for Photovoltaic Applications

    Directory of Open Access Journals (Sweden)

    VENMATHI, M.

    2016-02-01

    Full Text Available In this paper, a new four-port DC-DC converter topology is proposed to interface renewable energy sources and the load along with the energy storage device. The proposed four-port SEPIC/ZETA bidirectional converter (FP-SEPIC/ZETA BDC converter comprises an isolated output port with two unidirectional and one bidirectional input ports. This converter topology is obtained by the fusion of SEPIC/ZETA BDC and full-bridge converter. This converter topology ensures the non-reversal of output voltage hence it is preferred mostly for battery charging applications. In this work, photovoltaic (PV source is considered and the power balance in the system is achieved by means of distributed maximum power point tracking (DMPPT in the PV ports. The centralized controller is implemented using fuzzy logic controller (FLC and the performance is compared with conventional proportional integral (PI controller. The results offer useful information to obtain the desired output under line and load regulations. Experimental results are also provided to validate the simulation results.

  15. Market Potential Indicators- a Comparative Analysis of Brazil and India

    Directory of Open Access Journals (Sweden)

    E. H. Abbasi

    2014-06-01

    Full Text Available This article analyzes the relations between the market potential indicators and their subsequent impact on the investment decision factors. After discussing the various elements in the form of index and their various dimensions that distinguish countries capabilities and their potentials, we will analyze how Brazil and India are coping with the requirement of the investment opportunities and how they fared when compared to each other. The last section systematizes a few perspectives regarding the two countries and what policies should be adopted by them to compete with the other developing and developed nations. The various economic reforms can help these two countries to be in the league of front runner among the emerging markets.

  16. Market Potential Indicators- a Comparative Analysis of Brazil and India

    Directory of Open Access Journals (Sweden)

    Ehtesham Husain Abbasi

    2014-01-01

    Full Text Available This article analyzes the relations between the market potential indicators and their subsequent impact on the investment decision factors. After discussing the various elements in the form of index and their various dimensions that distinguish countries capabilities and their potentials, we will analyze how Brazil and India are coping with the requirement of the investment opportunities and how they fared when compared to each other. The last section systematizes a few perspectives regarding the two countries and what policies should be adopted by them to compete with the other developing and developed nations. The various economic reforms can help these two countries to be in the league of front runner among the emerging markets.

  17. AN ANALYSIS OF THE ENTREPRENEURIAL POTENTIAL IN OLTENIA TOURIST REGION

    Directory of Open Access Journals (Sweden)

    Ionuţ Cosmin BĂLOI

    2014-06-01

    Full Text Available Tourism can bring an attractive horizon for Romania: the projects can generate jobs, cooperation between the touristic destinations, the increase of living standards and local people revenues. This paper treats an issue of tourist business administration and seeks to assess the actual potential of tourist resources and determining the differences between the Oltenia's actual touristic exploitation and their growth potential. We develop a model of evaluate the tourist resources, the industry efficiency and also their attractiveness for entrepreneurial initiatives. Their quantification can be statistically correlated leading to a rethinking of models that shape the parameters of regional competitiveness. The synthetic and the graphic tools highlights the most important features of the competitiveness of tourism for the region of Oltenia.

  18. ANALYSIS OF THE DEMOGRAPHIC POTENTIAL IN FUNCTION OF TOURISM

    Directory of Open Access Journals (Sweden)

    Mijalce Gjorgievski

    2011-06-01

    Full Text Available Man is the prime mover of the overall social economic and political life of the entire globe and therefore he is studied from various aspects depending on the needs of what we want to obtain information on the demographic potential and its features.In this paper, the subject of study will be processing potential through its demographic characteristics (number condition, age structure, natural increase, economic activity, religious composition, etc. for the tourism economy. We know that the basic elements of tourism are the natural and cultural wealth that detect, evaluate and put into operation in tourism. However, it has its function, the basic factor are the people who need to visit those places, so it is very important to understand the demographic characteristics of people in every region of the globe in order to come to some understanding of the habits, needs and affinities of people depending on age, nationality and religious affiliation, etc. when choosing their travel destination.

  19. Dynamical analysis of Schrodinger operators with growing sparse potentials

    CERN Document Server

    Tcheremchantsev, S

    2003-01-01

    We consider Scr\\"odinger operators in l^2(Z^+) with potentials of the form V(n)=S(n)+Q(n). Here S is a sparse potential: S(n)=n^{1-\\eta \\over 2 \\eta}, 0<\\eta <1, for n=L_N and S(n)=0 else, where L_N is a very fast growing sequence. The real function Q(n) is compactly supported. We give a rather complete description of the (time-averaged) dynamics exp(-itH) \\psi for different initial states \\psi. In particular, for some \\psi we calculate explicitely the "intermittency function" \\beta_\\psi^- (p) which turns out to be nonconstant. As a particular corollary of obtained results, we show that the spectral measure restricted to (-2,2) has exact Hausdorff dimension \\eta for all boundary conditions, improving the result of Jitomirskaya and Last.

  20. Single-sweep spectral analysis of contact heat evoked potentials

    DEFF Research Database (Denmark)

    Hansen, Tine M; Graversen, Carina; Frøkjaer, Jens B

    2015-01-01

    AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single-sweep ch......AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single...... by 13% (P = 0.04) and 9% (P = 0.007), while the beta and gamma bands were increased by 10% (P = 0.006) and 24% (P = 0.04). CONCLUSION: The decreases in the delta and theta band are suggested to represent a decrease in the pain specific morphology of the CHEPs, which indicates a diminished pain response...

  1. Masking of the CD3 gamma di-leucine-based motif by zeta is required for efficient T-cell receptor expression

    DEFF Research Database (Denmark)

    Lauritsen, Jens Peter H; Bonefeld, Charlotte Menné; von Essen, Marina

    2004-01-01

    containing the di-leucine-based endocytosis motif of the TCR subunit CD3 gamma have indicated that the zeta chain can mask this motif. In this study, we show that successive truncations of the cytoplasmic tail of zeta led to reduced surface expression levels of completely assembled TCR complexes. The reduced...... TCR expression levels were caused by an increase in the TCR endocytic rate constant in combination with an unaffected exocytic rate constant. Furthermore, the TCR degradation rate constant was increased in cells with truncated zeta. Introduction of a CD3 gamma chain with a disrupted di-leucine...

  2. A new approach to triggering mechanism of volcano landslides based on zeta potential and surface free energy balance

    Science.gov (United States)

    Plaza, I.; Ontiveros-Ortega, A.; Calero, J.; Romero, C.

    2018-01-01

    The layers of Almagre (iron-rich deposits) from Tenerife Island are the result of thermal metamorphism of soils in contact with lava flow (1073-1273 K). These layers of small thickness relative to the basaltic wash, are interesting for geotechnical study, because the stability of the deposits is determined by the weakest element, in this case Almagre, which acts as a sliding plane. The flow of maritime air over the hillsides of the volcanic islands increases the content of cations in ashes deposits. This modifies the superficial properties of material that composes the substratum. This modification affects the retention of water and the cohesion of material making up the deposit. The results show that the presence of sodium and magnesium increased the hydrophobicity of the material, which had a weak water retention capacity and strong cohesion at basic pH. When there is iron in solution, repulsion between the particles is greater than one obtained with other studied electrolytes. Hence, the deposit is less stable, and Almagre under saturated water conditions constitutes an ideal layer for landslides.

  3. IMPLICATIONS OF MICROBIAL ADHESION TO HYDROCARBONS FOR EVALUATING CELL-SURFACE HYDROPHOBICITY .1. ZETA-POTENTIALS OF HYDROCARBON DROPLETS

    NARCIS (Netherlands)

    BUSSCHER, HJ; VANDEBELTGRITTER, B; VANDERMEI, HC

    1995-01-01

    Microbial adhesion to hydrocarbons (MATH) is generally considered to be a measure of the organisms cell surface hydrophobicity. As microbial adhesion is a complicated interplay of long-range van der Waals and electrostatic forces and various short-range interactions, the above statement only holds

  4. Zeta-potential and flotability of the scheelite mineral in different type of waters, Part 2: Flotability

    Directory of Open Access Journals (Sweden)

    Milanović Dragan B.

    2009-01-01

    Full Text Available The aim of this work was to study floatability of the mineral sheelite from mine 'Rudnik', central Serbia. Flotation tests of the mineral in a Hallimond tube cell were carried out in four different types of water, namely: tap water, distilled water, rain water and spring water. All types of water had different hardness and conductivity as well as natural pH values. It was found that the flotability of mineral scheelite depends on the hardness and electro-conductivity of the chosen type of water as well as on Ca2+ content. Also, it was found the floatability of mineral depends on the scheelite particle size fraction used in microflotation experiments. Presented results may be useful for proper selection of type of water, as well of the type of reagents used in flotation processes.

  5. Ion Adsorption Parameters Determined from Zeta Potential and Titration Data for a y-Alumina Nanofiltration Membrane

    NARCIS (Netherlands)

    de Lint, W.B.S.; Benes, Nieck Edwin; Lyklema, Johannes; Bouwmeester, Henricus J.M.; van der Linde, Ab J.; Wessling, Matthias

    2003-01-01

    Theoretical models for the prediction of nanofiltration separation performance as a function of, e.g., pH and electrolyte composition require knowledge on the ion-surface adsorption chemistry. Adsorption parameters have been extracted from electrophoretic mobility measurements on a ceramic y-alumina

  6. Ion adsorption parameters determined from zeta potential and titration data for a gamma-alumina nanofiltration membrane

    NARCIS (Netherlands)

    Samuel de Lint, W.B.; Benes, N.E.; Lyklema, J.; Bouwmeester, H.J.M.; Linde, van der A.J.; Wessling, M.

    2003-01-01

    Theoretical models for the prediction of nanofiltration separation performance as a function of, e.g., pH and electrolyte composition require knowledge on the ion-surface adsorption chemistry. Adsorption parameters have been extracted from electrophoretic mobility measurements on a ceramic -alumina

  7. The Potential Unity of Critical Thinking and Values Analysis.

    Science.gov (United States)

    Browne, M. Neil

    Metaphorically, the head and the heart represent different decision-making strategies. The disjunction between these two cultures is both sharp and unnecessary. The conflict between rationality and emotion is much broader than the tension between critical thinking and values analysis, but the assumptions responsible for the mutual awkwardness of…

  8. Potential and limitations of wave intensity analysis in coronary arteries

    NARCIS (Netherlands)

    Siebes, M.; Kolyva, C.; Verhoeff, B.J.; Piek, J.J.; Spaan, J.A.

    2009-01-01

    Wave intensity analysis (WIA) is beginning to be applied to the coronary circulation both to better understand coronary physiology and as a diagnostic tool. Separation of wave intensity (WI) into forward and backward traveling components requires knowledge of pulse wave velocity at the point of

  9. GIS Based Analysis of future district heating potential in Denmark

    DEFF Research Database (Denmark)

    Nielsen, Steffen; Möller, Bernd

    2012-01-01

    and their heat demand has in recent years been assessed in a heat atlas including all buildings in Denmark. The focus in this article is to further develop a method for assessing the costs associated with supplying these buildings with DH. The analysis takes departure in the existing DH areas in Denmark...

  10. GIS based analysis of future district heating potential in Denmark

    DEFF Research Database (Denmark)

    Nielsen, Steffen; Möller, Bernd

    2013-01-01

    in Denmark have been mapped in a heat atlas which includes all buildings and their heat demands. This article focuses on developing a method for assessing the costs associated with supplying these buildings with DH. The analysis is based on the existing DH areas in Denmark. By finding the heat production...

  11. Time series analysis in astronomy: Limits and potentialities

    DEFF Research Database (Denmark)

    Vio, R.; Kristensen, N.R.; Madsen, Henrik

    2005-01-01

    In this paper we consider the problem of the limits concerning the physical information that can be extracted from the analysis of one or more time series ( light curves) typical of astrophysical objects. On the basis of theoretical considerations and numerical simulations, we show that with no a...

  12. 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells

    International Nuclear Information System (INIS)

    Macha, Muzafar A; Matta, Ajay; Chauhan, SS; Siu, KW Michael; Ralhan, Ranju

    2010-01-01

    The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-targeted therapies. 14-3-3 zeta, a multifunctional phospho-serine/phospho-threonine binding protein, is emerging as an effector of pro-survival signaling by binding to several proteins involved in apoptosis (Bad, FKHRL1 and ASK1) and may serve as an appropriate target for head and neck cancer therapy. Herein, we determined effect of guggulsterone (GS), a farnesoid X receptor antagonist, on 14-3-3 zeta associated molecular pathways for abrogation of apoptosis in head and neck cancer cells. Head and neck cancer cells were treated with guggulsterone (GS). Effect of GS-treatment was evaluated using cell viability (MTT) assay and apoptosis was verified by annexin V, DNA fragmentation and M30 CytoDeath antibody assay. Mechanism of GS-induced apoptosis was determined by western blotting and co-IP assays using specific antibodies. Using in vitro models of head and neck cancer, we showed 14-3-3 zeta as a key player regulating apoptosis in GS treated SCC4 cells. Treatment with GS releases BAD from the inhibitory action of 14-3-3 zeta in proliferating HNSCC cells by activating protein phosphatase 2A (PP2A). These events initiate the intrinsic mitochondrial pathway of apoptosis, as revealed by increased levels of cytochrome c in cytoplasmic extracts of GS-treated SCC4 cells. In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis. These events were followed by activation of caspase 9, caspase 8 and caspase 3 leading to cleavage of its downstream target, poly-ADP-ribose phosphate (PARP). GS targets 14-3-3 zeta associated cellular pathways for reducing

  13. Energy storage: potential analysis is still on the way

    International Nuclear Information System (INIS)

    Signoret, Stephane; Dejeu, Mathieu; Deschaseaux, Christelle; De Santis, Audrey; Cygler, Clement; Petitot, Pauline

    2014-01-01

    A set of articles gives an overview of the status and current evolutions of the energy storage sector. The different technologies (flywheel, lithium-ion batteries, NaS or Zebra batteries, compressed air energy storage or CAES, 2. generation CAES, pump storage power plants or PSP) have different applications areas, and also different technological maturity levels. PSPs have probably the best potential nowadays, but investors must be supported. In an interview, a member of the CNRS evokes the main researches, the obstacles in the development of solar thermodynamic plants, technology transfers, and the potential of hydrogen for massive energy storage. An article outlines the need to develop the battery market. Several technological examples and experiments are then presented: Nice Grid (storage at the source level), FlyProd (energy storage by flywheel). An article then addresses the issue of heat storage, notably in a situation of energy co-generation. Researches and prototype development are then presented, the objective of which is to obtain an adiabatic CAES. The last articles address the development of hydrogen to store energy (technologies) and a first technological demonstrator

  14. Colorimetric Analysis of Hibiscus Beverages and their Potential Antioxidant Properties.

    Science.gov (United States)

    Camelo-Méndez, G A; Vanegas-Espinoza, P E; Escudero-Gilete, M L; Heredia, F J; Paredes-López, O; Del Villar-Martínez, A A

    2018-05-25

    In food industry, roselle beverages and their subproducts could be functional ingredients since they are an excellent source of bioactive compounds with improved performance due to their important anthocyanins content. The aim of this study was to analyze anthocyanin content and antioxidant properties of aqueous infusions elaborated with color contrasting Hibiscus materials and design a mathematical model in order to predict color-composition relationship. Color measurements of beverages from roselle (Negra, Sudan and Rosa) were made by transmission spectrophotometry, anthocyanins quantification was determined by HPLC, and antioxidant potential was evaluated by in vitro methods (ABTS and FRAP assays). Beverages prepared with particle size minor of 250 μm presented until 4- and 2- times more anthocyanins content and antioxidant capacity respectively, in comparison to beverages prepared with powders with particle size major of 750 μm. Positive correlations among pigments composition and color parameters were found (p Hibiscus beverages with high anthocyanin content. The obtained models could be an important tool to be used in food industry for pigment characterization or functional compounds with potential health benefits.

  15. Analysis of investment potential for enterprises of economic agrarian sector

    Directory of Open Access Journals (Sweden)

    A.E. Dankevych

    2017-12-01

    Full Text Available The article deals with and determines the peculiarities of the investment potential of lands of Ukrainian economic agrarian sector. The author studies the main positives contributing the development of investment for enterprises of agricultural purpose. The reasons that restrain the investment in agriculture are determined. It is emphasized that when using land resources, one should take into account the current specificity of environment in the economic agrarian sector. The article singles out the factors, which form the specificity of development of lease land relations. It is stressed that the important characteristic of lease land relations is their social and economic direction. It is proved that the obligatory condition of a lease agreement has to become the characteristic of a quality state for a land plot. More than a third part of all national income of the country was formed in economic agrarian sector. In particular, 70 % of total amount of retail goods turnover, a third part of main production facilities, a fourth part of population, employed in the Ukrainian economy, was busy working. According to the data of UNO, the potential of Ukrainian lands allows to provide about 100 mln. individuals with foods. To reach this and to renew the present level under current economic conditions one can due to the implementation of essentially new approaches to the organization of agricultural production.

  16. The potential of shared value creation: a theoretical analysis

    Directory of Open Access Journals (Sweden)

    Victor Danciu

    2016-06-01

    Full Text Available The urgent issues economy, environment and society are facing need new approaches which allow a well-balanced sharing of value created by the economy. A step forward is the concept of shared value creation. This paper aims to analyze the main features, the content of strategy of shared value creation and to propose the social innovation as main strategic way of shared value creation. At the beginning, the drivers and challenges of shared value creation are investigated in a systematized manner, in order to better understand why this new way of doing business is needed. Then, the concept and the three levels of shared value creation are investigated as sources of economic, environmental and social benefits that a business creates. These benefits depend on how efficient and diligent the company works. We are advancing the social innovation as main strategy having the greatest potential to create value with economic, environmental and social benefits. Finally, a framework for measurement of shared value creation is included. This framework is aiming at giving a tool for checking up the potential the shared value creation has for solving environmental and social issues.

  17. Probability theory versus simulation of petroleum potential in play analysis

    Science.gov (United States)

    Crovelli, R.A.

    1987-01-01

    An analytic probabilistic methodology for resource appraisal of undiscovered oil and gas resources in play analysis is presented. This play-analysis methodology is a geostochastic system for petroleum resource appraisal in explored as well as frontier areas. An objective was to replace an existing Monte Carlo simulation method in order to increase the efficiency of the appraisal process. Underlying the two methods is a single geologic model which considers both the uncertainty of the presence of the assessed hydrocarbon and its amount if present. The results of the model are resource estimates of crude oil, nonassociated gas, dissolved gas, and gas for a geologic play in terms of probability distributions. The analytic method is based upon conditional probability theory and a closed form solution of all means and standard deviations, along with the probabilities of occurrence. ?? 1987 J.C. Baltzer A.G., Scientific Publishing Company.

  18. Predicting the Market Potential Using Time Series Analysis

    Directory of Open Access Journals (Sweden)

    Halmet Bradosti

    2015-12-01

    Full Text Available The aim of this analysis is to forecast a mini-market sales volume for the period of twelve months starting August 2015 to August 2016. The study is based on the monthly sales in Iraqi Dinar for a private local mini-market for the month of April 2014 to July 2015. As revealed on the graph and of course if the stagnant economic condition continues, the trend of future sales is down-warding. Based on time series analysis, the business may continue to operate and generate small revenues until August 2016. However, due to low sales volume, low profit margin and operating expenses, the revenues may not be adequate enough to produce positive net income and the business may not be able to operate afterward. The principal question rose from this is the forecasting sales in the region will be difficult where the business cycle so dynamic and revolutionary due to systematic risks and unforeseeable future.

  19. Clinical Trials Using Anti-CD19/CD28/CD3zeta CAR Gammaretroviral Vector-transduced Autologous T Lymphocytes KTE-C19

    Science.gov (United States)

    NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying anti-cd19/cd28/cd3zeta car gammaretroviral vector-transduced autologous t lymphocytes kte-c19.

  20. Analysis reveals potential rangeland impacts if Williamson Act eliminated

    Directory of Open Access Journals (Sweden)

    William C. Wetzel

    2012-10-01

    Full Text Available California budget cuts have resulted in dramatic reductions in state funding for the Williamson Act, a land protection program that reduces property taxes for the owners of 15 million acres of California farms and rangeland. With state reimbursements to counties eliminated, the decision to continue Williamson Act contracts lies with individual counties. We investigated the consequences of eliminating the Williamson Act, using a geospatial analysis and a mail questionnaire asking ranchers for plans under a hypothetical elimination scenario. The geospatial analysis revealed that 72% of rangeland parcels enrolled in Williamson Act contracts contained habitat important for statewide conservation goals. Presented with the elimination scenario, survey respondents reported an intention to sell 20% of their total 496,889 acres. The tendency of survey participants to respond that they would sell land was highest among full-time ranchers with low household incomes and without off-ranch employment. A majority (76% of the ranchers who reported that they would sell land predicted that the buyers would develop it for nonagricultural uses, suggesting substantial changes to California's landscape in a future without the Williamson Act.

  1. DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering.

    Science.gov (United States)

    Haddad, Yazan; Dostalova, Simona; Kudr, Jiri; Zitka, Ondrej; Heger, Zbynek; Adam, Vojtech

    2017-11-09

    Isolation of DNA using magnetic particles is a field of high importance in biotechnology and molecular biology research. This protocol describes the evaluation of DNA-magnetic particles binding via dynamic light scattering (DLS) and electrophoretic light scattering (ELS). Analysis by DLS provides valuable information on the physicochemical properties of particles including particle size, polydispersity, and zeta potential. The latter describes the surface charge of the particle which plays major role in electrostatic binding of materials such as DNA. Here, a comparative analysis exploits three chemical modifications of nanoparticles and microparticles and their effects on DNA binding and elution. Chemical modifications by branched polyethylenimine, tetraethyl orthosilicate and (3-aminopropyl)triethoxysilane are investigated. Since DNA exhibits a negative charge, it is expected that zeta potential of particle surface will decrease upon binding of DNA. Forming of clusters should also affect particle size. In order to investigate the efficiency of these particles in isolation and elution of DNA, the particles are mixed with DNA in low pH (~6), high ionic strength and dehydration environment. Particles are washed on magnet and then DNA is eluted by Tris-HCl buffer (pH = 8). DNA copy number is estimated using quantitative polymerase chain reaction (PCR). Zeta potential, particle size, polydispersity and quantitative PCR data are evaluated and compared. DLS is an insightful and supporting method of analysis that adds a new perspective to the process of screening of particles for DNA isolation.

  2. Analysis of ethanol production potential from cellulosic feedstocks

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J E

    1982-03-01

    This report provides a comprehensive and scientific overview of results emerging from research on ethanol producton from cellulosic materials and indicates those areas which appear to warrant additional support. Many published economic analyses of production costs are examined, but the emphasis of the report is on research and on its potential for reducing the cost of ethanol production. The author concludes that the uncertainty surrounding the cost of producing ethanol from cellulosic feedstocks via enzymatic hydrolysis will not be resolved until a pilot plant has been built of sufficient size to produce realistic engineering data. He gives five reasons why Canada should build such a pilot plant: Canada's apparent leadership in developing a steam pre-treatment process, the desirability of encouraging developments and building a cadre of experts in biotechnology, the absence of a pilot plant in Canada where the various organisms and biochemical processes involved in ethanol production and by-product utilization can be developed on a reasonably large scale, Canadian expertise in lignin chemistry which might be used to capitalize upon the reactive lignin residue, and research in progress at National Research Council and elsewhere on the conversion of C/sub 5/ sugars to ethanol. 37 refs., 2 figs., 4 tabs.

  3. Sanitary landfill energetic potential analysis: a real case study

    International Nuclear Information System (INIS)

    Desideri, Umberto; Di Maria, Francesco; Leonardi, Daniela; Proietti, Stefania

    2003-01-01

    Waste disposal represents an important problem in developed countries. Many different techniques are available to reduce the amount of waste production and its environmental impact. In most cases, sanitary landfills have been and continue to be one of the most common ways to dispose of urban and industrial wastes. It is well known how landfilling produces an important environmental drawback due to gaseous, liquid and solid emissions that are dangerous for the environment. Landfill biogas emissions contain mainly carbon dioxide and methane. In particular, the methane concentration can be higher than 50% by volume. This means that the calorific value of sanitary landfill biogas can be higher than 18,000 kJ/N m 3 . The utilization of such gas as fuel for electrical and thermal energy production can be an important way to reduce the landfill impact on the environment and represent an easy way to use a renewable energy source. In the following, the amount and composition of the biogas produced in a sanitary landfill situated in central Italy have been analysed. Experimental results have been discussed, and an energetic potential evaluation has been performed

  4. Sanitary landfill energetic potential analysis: a real case study

    Energy Technology Data Exchange (ETDEWEB)

    Desideri, Umberto E-mail: umberto.desideri@unipg.it; Di Maria, Francesco E-mail: fdm@unipg.it; Leonardi, Daniela; Proietti, Stefania

    2003-07-01

    Waste disposal represents an important problem in developed countries. Many different techniques are available to reduce the amount of waste production and its environmental impact. In most cases, sanitary landfills have been and continue to be one of the most common ways to dispose of urban and industrial wastes. It is well known how landfilling produces an important environmental drawback due to gaseous, liquid and solid emissions that are dangerous for the environment. Landfill biogas emissions contain mainly carbon dioxide and methane. In particular, the methane concentration can be higher than 50% by volume. This means that the calorific value of sanitary landfill biogas can be higher than 18,000 kJ/N m{sup 3}. The utilization of such gas as fuel for electrical and thermal energy production can be an important way to reduce the landfill impact on the environment and represent an easy way to use a renewable energy source. In the following, the amount and composition of the biogas produced in a sanitary landfill situated in central Italy have been analysed. Experimental results have been discussed, and an energetic potential evaluation has been performed.

  5. Analysis of cracking potential and micro-elongation of linerboard

    Directory of Open Access Journals (Sweden)

    Supattra Panthai

    2016-11-01

    Full Text Available Folding cracks of linerboards in relation to their micro-elongation and the forming conditions were studied using an industrial linerboard machine with a top former. The experiments consisted of the study of various forming conditions by manipulating the jet/wire speed ratio to produce linerboard with differences in fiber structures that were related to the cracked and uncracked products. The results showed that changes to the jet/wire speed ratio of about 0.01–0.02 to improve the tested folding endurance in the machine direction potentially produced folding cracks in the linerboard, which indicated an ambiguous interpretation of the foldability tests. The delaminated cracked layers were found to have a high folding endurance and tensile strength, while the decrease in the micro-elongation formulated in this study was found to be related to cracking. A lower micro-elongation of about 350–500 μm/N·g was found in a range of products with folding cracks.

  6. Economic analysis of potential uses of geothermal energy in agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Cone, B.W.

    1978-02-01

    The economic feasibility and water quality considerations of the cultural practice of soil warming was evaluated using existing technical, agronomic, and economic data. It was hypothesized that it is technically and economically feasible to use geothermal energy in the cultural practice of soil warming for specific crops. The analysis attempted to reject the hypothesis. Since the hypothesis could not be rejected, the results are presented as a profit equation suitable for inclusion in the GEOCOST computer program. This determination of economic feasibility utilized heterogeneous crop yield data by comparing the elasticity of response with a normalized product-factor price ratio. Soil warming was determined to be feasible when the elasticity of production was equal to or greater than the normalized product-factor price ratio. A farm enterprise was determined profitable if net returns were positive. An empirical model in which the energy dissipation rate is a function of the difference between heat source temperature and mean monthly air temperature was transformed to utilize data describing the total heat applied during the growing season. Heat input was then measured as the total number of calories per square centimeter applied during the growing season.

  7. Thermal Management and Analysis for a Potential Yucca Mountain Repository

    International Nuclear Information System (INIS)

    Dr. A. Van Luik

    2004-01-01

    In the current Yucca Mountain repository design concept, heat from the emplaced waste (mostly from spent nuclear fuel) would keep the temperature of the rock around the waste packages higher than the boiling point of water for hundreds to thousands of years after the repository is closed. The design concept allows below-boiling portions of the pillars between drifts to serve as pathways for the drainage of thermally mobilized water and percolating groundwater by limiting the distance that boiling temperatures extend into the surrounding rock. This design concept takes advantage of host rock dry out, which would create a dry environment within the emplacement drifts and reduce the amount of water that might otherwise be available to enter the drifts and contact the waste packages during this thermal pulse. Table 1 provides an overview of design constraints related to thermal management after repository closure. The Yucca Mountain repository design concept also provides flexibility to allow for operation over a range of lower thermal operating conditions. The thermal conditions within the emplacement drifts can be varied, along with the relative humidity, by modifying operational parameters such as the thermal output of the waste packages, the spacing of the waste packages in the emplacement drifts, and the duration and rate of active and passive ventilation. A lower range has been examined to quantify lower-temperature thermal conditions (temperatures and associated humidity conditions) in the emplacement drifts and to quantify impacts to the required emplacement area and excavated drift length. This information has been used to evaluate the potential long-term performance of a lower-temperature repository and to estimate the increase in costs associated with operating a lower-temperature repository. This presentation provides an overview of the thermal management evaluations that have been conducted to investigate a range of repository thermal conditions and

  8. Thermal management and analysis for a potential yucca mountain repository

    International Nuclear Information System (INIS)

    Van Luik, A.

    2005-01-01

    In the current Yucca Mountain repository design concept, heat from the emplaced. waste (mostly from spent nuclear fuel.) would keep the temperature of the rock around the waste packages higher than the boiling point of water for hundreds to thousands of years after the repository is closed. The design concept allows below-boiling portions of the pillars between drifts to serve as pathways for the drainage of thermally mobilized water and percolating groundwater by limiting the distance that boiling temperatures extend into the surrounding rock. This design concept takes advantage of host rock dry out, which would create a dry environment within the emplacement drifts and reduce the amount of water that might otherwise be available to enter the drifts and contact the waste packages during this thermal pulse. The Yucca Mountain repository design concept also provides flexibility to allow for operation over a range of lower thermal operating conditions. The thermal conditions within the emplacement drifts can be varied, along with the relative humidity, by modifying operational parameters such as the thermal output of the waste packages, the spacing of the waste packages in the emplacement drifts, and. the duration and rate of active and passive ventilation. A lower range has been examined to quantify lower-temperature thermal conditions (temperatures and associated humidity conditions) in the emplacement drifts and to quantify impacts to the required emplacement area and excavated drift length. This information has been used to evaluate the potential long-term performance of a lower-temperature repository and to estimate the increase in costs associated with operating a lower-temperature repository. This presentation provides an overview of the thermal management evaluations that have been conducted to investigate a range of repository thermal conditions and includes a summary of the technical basis that supports these evaluations. The majority of the material

  9. Computer-assisted sperm analysis (CASA): capabilities and potential developments.

    Science.gov (United States)

    Amann, Rupert P; Waberski, Dagmar

    2014-01-01

    Computer-assisted sperm analysis (CASA) systems have evolved over approximately 40 years, through advances in devices to capture the image from a microscope, huge increases in computational power concurrent with amazing reduction in size of computers, new computer languages, and updated/expanded software algorithms. Remarkably, basic concepts for identifying sperm and their motion patterns are little changed. Older and slower systems remain in use. Most major spermatology laboratories and semen processing facilities have a CASA system, but the extent of reliance thereon ranges widely. This review describes capabilities and limitations of present CASA technology used with boar, bull, and stallion sperm, followed by possible future developments. Each marketed system is different. Modern CASA systems can automatically view multiple fields in a shallow specimen chamber to capture strobe-like images of 500 to >2000 sperm, at 50 or 60 frames per second, in clear or complex extenders, and in information for ≥ 30 frames and provide summary data for each spermatozoon and the population. A few systems evaluate sperm morphology concurrent with motion. CASA cannot accurately predict 'fertility' that will be obtained with a semen sample or subject. However, when carefully validated, current CASA systems provide information important for quality assurance of semen planned for marketing, and for the understanding of the diversity of sperm responses to changes in the microenvironment in research. The four take-home messages from this review are: (1) animal species, extender or medium, specimen chamber, intensity of illumination, imaging hardware and software, instrument settings, technician, etc., all affect accuracy and precision of output values; (2) semen production facilities probably do not need a substantially different CASA system whereas biology laboratories would benefit from systems capable of imaging and tracking sperm in deep chambers for a flexible period of time

  10. Consistent gaussian basis sets of double- and triple-zeta valence with polarization quality of the fifth period for solid-state calculations.

    Science.gov (United States)

    Laun, Joachim; Vilela Oliveira, Daniel; Bredow, Thomas

    2018-02-22

    Consistent basis sets of double- and triple-zeta valence with polarization quality for the fifth period have been derived for periodic quantum-chemical solid-state calculations with the crystalline-orbital program CRYSTAL. They are an extension of the pob-TZVP basis sets, and are based on the full-relativistic effective core potentials (ECPs) of the Stuttgart/Cologne group and on the def2-SVP and def2-TZVP valence basis of the Ahlrichs group. We optimized orbital exponents and contraction coefficients to supply robust and stable self-consistent field (SCF) convergence for a wide range of different compounds. The computed crystal structures are compared to those obtained with standard basis sets available from the CRYSTAL basis set database. For the applied hybrid density functional PW1PW, the average deviations of calculated lattice constants from experimental references are smaller with pob-DZVP and pob-TZVP than with standard basis sets. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

  11. Casimir energies in M4≥/sup N/ for even N. Green's-function and zeta-function techniques

    International Nuclear Information System (INIS)

    Kantowski, R.; Milton, K.A.

    1987-01-01

    The Green's-function technique developed in the first paper in this series is generalized to apply to massive scalar, vector, second-order tensor, and Dirac spinor fields, as a preliminary to a full graviton calculation. The Casimir energies are of the form u/sub Casimir/ = (1/a 4 )[α/sub N/lna/b)+β/sub N/], where N (even) is the dimension of the internal sphere, a is its radius, and b/sup -1/ is an ultraviolet cutoff (presumably at the Planck scale). The coefficient of the divergent logarithm, α/sub N/, is unambiguously obtained for each field considered. The Green's-function technique gives rise to no difficulties in the evaluation of imaginary-mass-mode contributions to the Casimir energy. In addition, a new, simplified zeta-function technique is presented which is very easily implemented by symbolic programs, and which, of course, gives the same results. An error in a previous zeta-function calculation of the Casimir energy for even N is pointed out

  12. Analysis of the Water Resources Potential and Useful Life of the ...

    African Journals Online (AJOL)

    Full Length R ... Keywords: Shiroro dam reservoir, water resources potential, useful life, hydropower, ... Water balance analysis is a highly effective tool that .... from operation each time the reservoir capacity ..... validity of this research work. iii.

  13. Future-oriented technology analysis: Its potential to address disruptive transformations

    OpenAIRE

    Gagnin, Cristiano; Havas, Attila; Saritas, Ozcan

    2011-01-01

    This paper reflects on the potential of future-oriented analysis (FTA) to address major change and to support decision-makers and other stakeholders in anticipating and dealing with transformations. It does so by critically reflecting on the selected papers for this special issue as well as on the discussions that took place at the fourth Seville International Conference on Future-oriented Technology Analysis. Considering the potential roles of FTA in enabling a better understanding of co...

  14. Permeability dependence of streaming potential coefficient in porous media

    NARCIS (Netherlands)

    Thanh, L.D.; Sprik, R.

    2015-01-01

    In theory, the streaming potential coefficient depends not only on the zeta potential but also on the permeability of the rocks that partially determines the surface conductivity of the rocks. However, in practice, it is hard to show the permeability dependence of streaming potential coefficients

  15. Effect of adsorption of charged macromolecules on streaming and membrane potential values measured with a microporous polysulfone membrane

    DEFF Research Database (Denmark)

    Benavente, J.; Jonsson, Gunnar Eigil

    1997-01-01

    with a polyanion (dextran sulfate or DS) and a polycation (diethylaminoethyl or DEAE-dextran). From electrokinetic and electrochemical measurements, information about characteristic membrane parameters (transport number and ionic permselectivity) and membrane/solution interactions (zeta potential) can be obtained...

  16. Mapping the brain pathways of traumatic memory: inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats.

    Science.gov (United States)

    Cohen, Hagit; Kozlovsky, Nitsan; Matar, Michael A; Kaplan, Zeev; Zohar, Joseph

    2010-04-01

    Protein kinase M zeta (PKMzeta), a constitutively active isoform of protein kinase C, has been implicated in protein synthesis-dependent maintenance of long-term potentiation and memory storage in the brain. Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations. This study assessed the long-term effects of local applications of ZIP microinjected immediately (1 h) or 10 days after predator scent stress exposure, in a controlled prospectively designed animal model for PTSD. Four brain structures known to be involved in memory processes and in anxiety were investigated: lateral ventricle (LV), dorsal hippocampus (DH), basolateral amygdala and IC. The outcome measures included behavior in an elevated plus maze and acoustic startle response 7 days after microinjection, and freezing behavior upon exposure to trauma-related cue 8 days after microinjection. Previously acquired/encoded memories associated with the IC were also assessed. Inactivation of PKMzeta in the LV or DH within 1h of exposure effectively reduced PTSD-like behavioral disruption and trauma cue response 8 days later. Inactivation of PKMzeta 10 days after exposure had equivalent effects only when administered in the IC. The effect was demonstrated to be specific for trauma memories, whereas previously acquired data were unaffected by the procedure. Predator scent related memories are located in different brain areas at different times beginning with an initial hippocampus-dependent consolidation process, and are eventually stored in the IC. These bring the IC to the forefront as a potential region of significance in processes related to traumatic stress-induced disorders. 2010 Elsevier B.V. and ECNP. All rights reserved.

  17. A novel conductivity mechanism of highly disordered carbon systems based on an investigation of graph zeta function

    Science.gov (United States)

    Matsutani, Shigeki; Sato, Iwao

    2017-09-01

    In the previous report (Matsutani and Suzuki, 2000 [21]), by proposing the mechanism under which electric conductivity is caused by the activational hopping conduction with the Wigner surmise of the level statistics, the temperature-dependent of electronic conductivity of a highly disordered carbon system was evaluated including apparent metal-insulator transition. Since the system consists of small pieces of graphite, it was assumed that the reason why the level statistics appears is due to the behavior of the quantum chaos in each granular graphite. In this article, we revise the assumption and show another origin of the Wigner surmise, which is more natural for the carbon system based on a recent investigation of graph zeta function in graph theory. Our method can be applied to the statistical treatment of the electronic properties of the randomized molecular system in general.

  18. Generalized zeta function representation of groups and 2-dimensional topological Yang-Mills theory: The example of GL(2, _q) and PGL(2, _q)

    International Nuclear Information System (INIS)

    Roche, Ph.

    2016-01-01

    We recall the relation between zeta function representation of groups and two-dimensional topological Yang-Mills theory through Mednikh formula. We prove various generalisations of Mednikh formulas and define generalization of zeta function representations of groups. We compute some of these functions in the case of the finite group GL(2, _q) and PGL(2, _q). We recall the table characters of these groups for any q, compute the Frobenius-Schur indicator of their irreducible representations, and give the explicit structure of their fusion rings.

  19. Failure to synthesize the human T-cell CD3-zeta chain and its consequence for the T-cell receptor-CD3 complex expression

    DEFF Research Database (Denmark)

    Geisler, C; Kuhlmann, J; Plesner, T

    1989-01-01

    components, the human T-cell tumour line Jurkat was chemically mutagenized followed by negative selection with F101.01 (a monoclonal antibody against the TcR-CD3 complex), and cloning. Growing clones were analysed for TcR-CD3 expression by immunofluorescence. One clone, J79, was found to express greatly...... diminished levels of TcR-CD3. This clone produced all the TcR-CD3 components except the CD3-zeta, as demonstrated by metabolic labelling and immunoprecipitation followed by one- and two-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis. These data indicate that the CD3-zeta determines...

  20. Hydrogen exchange rate of tyrosine hydroxyl groups in proteins as studied by the deuterium isotope effect on C(zeta) chemical shifts.

    Science.gov (United States)

    Takeda, Mitsuhiro; Jee, Jungoo; Ono, Akira Mei; Terauchi, Tsutomu; Kainosho, Masatsune

    2009-12-30

    We describe a new NMR method for monitoring the individual hydrogen exchange rates of the hydroxyl groups of tyrosine (Tyr) residues in proteins. The method utilizes (2S,3R)-[beta(2),epsilon(1,2)-(2)H(3);0,alpha,beta,zeta-(13)C(4);(15)N]-Tyr, zeta-SAIL Tyr, to detect and assign the (13)C(zeta) signals of Tyr rings efficiently, either by indirect (1)H-detection through 7-8 Hz (1)H(delta)-(13)C(zeta) spin couplings or by direct (13)C(zeta) observation. A comparison of the (13)C(zeta) chemical shifts of three Tyr residues of an 18.2 kDa protein, EPPIb, dissolved in H(2)O and D(2)O, revealed that all three (13)C(zeta) signals in D(2)O appeared at approximately 0.13 ppm ( approximately 20 Hz at 150.9 MHz) higher than those in H(2)O. In a H(2)O/D(2)O (1:1) mixture, however, one of the three signals for (13)C(zeta) appeared as a single peak at the averaged chemical shifts, and the other two appeared as double peaks at exactly the same chemical shifts in H(2)O and D(2)O, in 50 mM phosphate buffer (pH 6.6) at 40 degrees C. These three peaks were assigned to Tyr-36, Tyr-120, and Tyr-30, from the lower to higher chemical shifts, respectively. The results indicate that the hydroxyl proton of Tyr-120 exchanges faster than a few milliseconds, whereas those of Tyr-30 and Tyr-36 exchange more slowly. The exchange rate of the Tyr-30 hydroxyl proton, k(ex), under these conditions was determined by (13)C NMR exchange spectroscopy (EXSY) to be 9.2 +/- 1.1 s(-1). The Tyr-36 hydroxyl proton, however, exchanges too slowly to be determined by EXSY. These profound differences among the hydroxyl proton exchange rates are closely related to their relative solvent accessibility and the hydrogen bonds associated with the Tyr hydroxyl groups in proteins.

  1. Generalised analysis of the potential of an enterprise as a function of environmental parameters (theoretical approach

    Directory of Open Access Journals (Sweden)

    Karapeychik Igor M.

    2013-03-01

    Full Text Available Within the frameworks of the author’s concept of the potential of an enterprise as the ability to conduct its immanently appropriate activity and also the idea of presentation of the size of the potential in the form of potential function from parameters of the state of an enterprise and foreign economic environment the article develops a scientific and methodical approach to construction and analysis of the potential function of an enterprise. The offered approach envisages building an economic and mathematical model of an enterprise of the optimisation type with consideration of environmental factors, determination of the size of economic potential as a maximum possible (optimal with the set condition of an enterprise and external environment of net income, statistical test of the model with possible values of external parameters (formation of statistical sampling of the graph of the potential function of an enterprise and application of statistical methods including methods of correlation, factor and regression analysis, for the study of its properties. Operability of this approach is shown on the example of the study of properties of the potential function of a model enterprise. In the course of approbation the article demonstrates its ability to reveal specific features of impact of external factors on economic potential of an enterprise; establishes, as a common regularity, differential influence of various environmental factors, caused not only by the nature of these factors, but also production and economic specific features and specific state of an enterprise. The article shows that the quantitative values of the force of influence of the said factors upon the value of economic potential, obtained during statistical analysis of the potential function of an enterprise, could serve as an instrument of ranking these factors by the priority level in the goal setting tasks at the stage of formation of the strategy of enterprise development

  2. More on zeta-function regularization of high-temperature expansions

    International Nuclear Information System (INIS)

    Actor, A.

    1987-01-01

    A recent paper using the Riemann ζ-function to regularize the (divergent) coefficients occurring in the high-temperature expansions of one-loop thermodynamic potentials is extended. This method proves to be a powerful tool for converting Dirichlet-type series Σ m a m (x i )/m s into power series in the dimensionless parameters x i . The coefficients occurring in the power series are (proportional to) ζ-functions evaluated away from their poles - this is where the regularization occurs. High-temperature expansions are just one example of this highly-nontrivial rearrangement of Dirichlet series into power series form. We discuss in considerable detail series in which a m (x i ) is a product of trigonometric, algebraic and Bessel function factors. The ζ-function method is carefully explained, and a large number of new formulae are provided. The means to generalize these formulae are also provided. Previous results on thermodynamic potentials are generalized to include a nonzero constant term in the gauge potential (time component) which can be used to probe the electric sector of temperature gauge theories. (author)

  3. Comparison of Artificial Neural Networks and GIS Based Solar Analysis for Solar Potential Estimation

    Science.gov (United States)

    Konakoǧlu, Berkant; Usta, Ziya; Cömert, Çetin; Gökalp, Ertan

    2016-04-01

    Nowadays, estimation of solar potential plays an important role in planning process for sustainable cities. The use of solar panels, which produces electricity directly from the sun, has become popular in accordance with developing technologies. Since the use of solar panels enables the users to decrease costs and increase yields, the use of solar panels will be more popular in the future. Production of electricity is not convenient for all circumstances. Shading effects, massive clouds and rainy weather are some factors that directly affect the production of electricity from solar energy. Hence, before the installation of solar panels, it is crucial to conduct spatial analysis and estimate the solar potential of the place that the solar panel will be installed. There are several approaches to determine the solar potential. Examination of the applications in the literature reveals that the applications conducted for determining the solar potential are divided into two main categories. Solar potential is estimated either by using artificial neural network approach in which statistical parameters such as the duration of sun shine, number of clear days, solar radiation etc. are used, or by spatial analysis conducted in GIS approaches in which spatial parameters such as, latitude, longitude, slope, aspect etc. are used. In the literature, there are several studies that use both approaches but the literature lacks of a study related to the comparison of these approaches. In this study, Karadeniz Technical University campus has been selected as study area. Monthly average values of the number of clear sky days, air temperature, atmospheric pressure, relative humidity, sunshine duration and solar radiation parameters obtained for the years between 2005 and 2015 will be used to perform artificial neural network analysis to estimate the solar potential of the study area. The solar potential will also be estimated by using GIS-based solar analysis modules. The results of

  4. An Excel‐based implementation of the spectral method of action potential alternans analysis

    Science.gov (United States)

    Pearman, Charles M.

    2014-01-01

    Abstract Action potential (AP) alternans has been well established as a mechanism of arrhythmogenesis and sudden cardiac death. Proper interpretation of AP alternans requires a robust method of alternans quantification. Traditional methods of alternans analysis neglect higher order periodicities that may have greater pro‐arrhythmic potential than classical 2:1 alternans. The spectral method of alternans analysis, already widely used in the related study of microvolt T‐wave alternans, has also been used to study AP alternans. Software to meet the specific needs of AP alternans analysis is not currently available in the public domain. An AP analysis tool is implemented here, written in Visual Basic for Applications and using Microsoft Excel as a shell. This performs a sophisticated analysis of alternans behavior allowing reliable distinction of alternans from random fluctuations, quantification of alternans magnitude, and identification of which phases of the AP are most affected. In addition, the spectral method has been adapted to allow detection and quantification of higher order regular oscillations. Analysis of action potential morphology is also performed. A simple user interface enables easy import, analysis, and export of collated results. PMID:25501439

  5. An Excel-based implementation of the spectral method of action potential alternans analysis.

    Science.gov (United States)

    Pearman, Charles M

    2014-12-01

    Action potential (AP) alternans has been well established as a mechanism of arrhythmogenesis and sudden cardiac death. Proper interpretation of AP alternans requires a robust method of alternans quantification. Traditional methods of alternans analysis neglect higher order periodicities that may have greater pro-arrhythmic potential than classical 2:1 alternans. The spectral method of alternans analysis, already widely used in the related study of microvolt T-wave alternans, has also been used to study AP alternans. Software to meet the specific needs of AP alternans analysis is not currently available in the public domain. An AP analysis tool is implemented here, written in Visual Basic for Applications and using Microsoft Excel as a shell. This performs a sophisticated analysis of alternans behavior allowing reliable distinction of alternans from random fluctuations, quantification of alternans magnitude, and identification of which phases of the AP are most affected. In addition, the spectral method has been adapted to allow detection and quantification of higher order regular oscillations. Analysis of action potential morphology is also performed. A simple user interface enables easy import, analysis, and export of collated results. © 2014 The Author. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  6. Spatial data analysis and integration for regional-scale geothermal potential mapping, West Java, Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Carranza, Emmanuel John M.; Barritt, Sally D. [Department of Earth Systems Analysis, International Institute for Geo-information Science and Earth Observation (ITC), Enschede (Netherlands); Wibowo, Hendro; Sumintadireja, Prihadi [Laboratory of Volcanology and Geothermal, Geology Department, Institute of Technology Bandung (ITB), Bandung (Indonesia)

    2008-06-15

    Conceptual modeling and predictive mapping of potential for geothermal resources at the regional-scale in West Java are supported by analysis of the spatial distribution of geothermal prospects and thermal springs, and their spatial associations with geologic features derived from publicly available regional-scale spatial data sets. Fry analysis shows that geothermal occurrences have regional-scale spatial distributions that are related to Quaternary volcanic centers and shallow earthquake epicenters. Spatial frequency distribution analysis shows that geothermal occurrences have strong positive spatial associations with Quaternary volcanic centers, Quaternary volcanic rocks, quasi-gravity lows, and NE-, NNW-, WNW-trending faults. These geological features, with their strong positive spatial associations with geothermal occurrences, constitute spatial recognition criteria of regional-scale geothermal potential in a study area. Application of data-driven evidential belief functions in GIS-based predictive mapping of regional-scale geothermal potential resulted in delineation of high potential zones occupying 25% of West Java, which is a substantial reduction of the search area for further exploration of geothermal resources. The predicted high potential zones delineate about 53-58% of the training geothermal areas and 94% of the validated geothermal occurrences. The results of this study demonstrate the value of regional-scale geothermal potential mapping in: (a) data-poor situations, such as West Java, and (b) regions with geotectonic environments similar to the study area. (author)

  7. Image analysis in the evaluation of the physiological potential of maize seeds1

    Directory of Open Access Journals (Sweden)

    Crislaine Aparecida Gomes Pinto

    Full Text Available The Seed Analysis System (SAS is used in the image analysis of seeds and seedlings, and has the potential for use in the control of seed quality. The aim of this research was to adapt the methodology of image analysis of maize seedlings by SAS, and to verify the potential use of this equipment in the evaluation of the physiological potential of maize seeds. Nine batches of two maize hybrids were characterised by means of the following tests and determinations: germination, first count, accelerated ageing, cold test, seedling emergence at 25 and 30ºC, and speed of emergence index. The image analysis experiment was carried out in a factorial scheme of 9 batches x 4 methods of analysis of the seedling images (with and without the use of NWF as substrate, and with and without manual correction of the images. Images of the seedlings were evaluated using the average lengths of the coleoptile, roots and seedlings; and by the automatic and manual indices of vigour, uniformity and growth produced by the SAS. Use of blue NWF afffects the initial development of maize seedlings. The physiological potential of maize seeds can be evaluated in seedlings which are seeded on white paper towels at a temperature of 25 °C and evaluated on the third day. Image analysis should be carried out with the SAS software using automatic calibration and with no correction of the seedling images. Use of SAS equipment for the analysis of seedling images is a potential tool in evaluating the physiological quality of maize seeds.

  8. Spectral neighbor analysis method for automated generation of quantum-accurate interatomic potentials

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Aidan P. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States). Multiscale Science Dept.; Swiler, Laura P. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States). Optimization and Uncertainty Quantification Dept.; Trott, Christian R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Scalable Algorithms Dept.; Foiles, Stephen M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Computational Materials and Data Science Dept.; Tucker, Garritt J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Computational Materials and Data Science Dept.; Drexel Univ., Philadelphia, PA (United States). Dept. of Materials Science and Engineering

    2015-03-15

    Here, we present a new interatomic potential for solids and liquids called Spectral Neighbor Analysis Potential (SNAP). The SNAP potential has a very general form and uses machine-learning techniques to reproduce the energies, forces, and stress tensors of a large set of small configurations of atoms, which are obtained using high-accuracy quantum electronic structure (QM) calculations. The local environment of each atom is characterized by a set of bispectrum components of the local neighbor density projected onto a basis of hyperspherical harmonics in four dimensions. The bispectrum components are the same bond-orientational order parameters employed by the GAP potential [1]. The SNAP potential, unlike GAP, assumes a linear relationship between atom energy and bispectrum components. The linear SNAP coefficients are determined using weighted least-squares linear regression against the full QM training set. This allows the SNAP potential to be fit in a robust, automated manner to large QM data sets using many bispectrum components. The calculation of the bispectrum components and the SNAP potential are implemented in the LAMMPS parallel molecular dynamics code. We demonstrate that a previously unnoticed symmetry property can be exploited to reduce the computational cost of the force calculations by more than one order of magnitude. We present results for a SNAP potential for tantalum, showing that it accurately reproduces a range of commonly calculated properties of both the crystalline solid and the liquid phases. In addition, unlike simpler existing potentials, SNAP correctly predicts the energy barrier for screw dislocation migration in BCC tantalum.

  9. Spectral neighbor analysis method for automated generation of quantum-accurate interatomic potentials

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, A.P., E-mail: athomps@sandia.gov [Multiscale Science Department, Sandia National Laboratories, PO Box 5800, MS 1322, Albuquerque, NM 87185 (United States); Swiler, L.P., E-mail: lpswile@sandia.gov [Optimization and Uncertainty Quantification Department, Sandia National Laboratories, PO Box 5800, MS 1318, Albuquerque, NM 87185 (United States); Trott, C.R., E-mail: crtrott@sandia.gov [Scalable Algorithms Department, Sandia National Laboratories, PO Box 5800, MS 1322, Albuquerque, NM 87185 (United States); Foiles, S.M., E-mail: foiles@sandia.gov [Computational Materials and Data Science Department, Sandia National Laboratories, PO Box 5800, MS 1411, Albuquerque, NM 87185 (United States); Tucker, G.J., E-mail: gtucker@coe.drexel.edu [Computational Materials and Data Science Department, Sandia National Laboratories, PO Box 5800, MS 1411, Albuquerque, NM 87185 (United States); Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104 (United States)

    2015-03-15

    We present a new interatomic potential for solids and liquids called Spectral Neighbor Analysis Potential (SNAP). The SNAP potential has a very general form and uses machine-learning techniques to reproduce the energies, forces, and stress tensors of a large set of small configurations of atoms, which are obtained using high-accuracy quantum electronic structure (QM) calculations. The local environment of each atom is characterized by a set of bispectrum components of the local neighbor density projected onto a basis of hyperspherical harmonics in four dimensions. The bispectrum components are the same bond-orientational order parameters employed by the GAP potential [1]. The SNAP potential, unlike GAP, assumes a linear relationship between atom energy and bispectrum components. The linear SNAP coefficients are determined using weighted least-squares linear regression against the full QM training set. This allows the SNAP potential to be fit in a robust, automated manner to large QM data sets using many bispectrum components. The calculation of the bispectrum components and the SNAP potential are implemented in the LAMMPS parallel molecular dynamics code. We demonstrate that a previously unnoticed symmetry property can be exploited to reduce the computational cost of the force calculations by more than one order of magnitude. We present results for a SNAP potential for tantalum, showing that it accurately reproduces a range of commonly calculated properties of both the crystalline solid and the liquid phases. In addition, unlike simpler existing potentials, SNAP correctly predicts the energy barrier for screw dislocation migration in BCC tantalum.

  10. Spectral neighbor analysis method for automated generation of quantum-accurate interatomic potentials

    International Nuclear Information System (INIS)

    Thompson, A.P.; Swiler, L.P.; Trott, C.R.; Foiles, S.M.; Tucker, G.J.

    2015-01-01

    We present a new interatomic potential for solids and liquids called Spectral Neighbor Analysis Potential (SNAP). The SNAP potential has a very general form and uses machine-learning techniques to reproduce the energies, forces, and stress tensors of a large set of small configurations of atoms, which are obtained using high-accuracy quantum electronic structure (QM) calculations. The local environment of each atom is characterized by a set of bispectrum components of the local neighbor density projected onto a basis of hyperspherical harmonics in four dimensions. The bispectrum components are the same bond-orientational order parameters employed by the GAP potential [1]. The SNAP potential, unlike GAP, assumes a linear relationship between atom energy and bispectrum components. The linear SNAP coefficients are determined using weighted least-squares linear regression against the full QM training set. This allows the SNAP potential to be fit in a robust, automated manner to large QM data sets using many bispectrum components. The calculation of the bispectrum components and the SNAP potential are implemented in the LAMMPS parallel molecular dynamics code. We demonstrate that a previously unnoticed symmetry property can be exploited to reduce the computational cost of the force calculations by more than one order of magnitude. We present results for a SNAP potential for tantalum, showing that it accurately reproduces a range of commonly calculated properties of both the crystalline solid and the liquid phases. In addition, unlike simpler existing potentials, SNAP correctly predicts the energy barrier for screw dislocation migration in BCC tantalum

  11. Construction of integrable model Kohn-Sham potentials by analysis of the structure of functional derivatives

    International Nuclear Information System (INIS)

    Gaiduk, Alex P.; Staroverov, Viktor N.

    2011-01-01

    A directly approximated exchange-correlation potential should, by construction, be a functional derivative of some density functional in order to avoid unphysical results. Using generalized gradient approximations (GGAs) as an example, we show that functional derivatives of explicit density functionals have a very rigid inner structure, the knowledge of which allows one to build the entire functional derivative from a small part. Based on this analysis, we develop a method for direct construction of integrable Kohn-Sham potentials. As an illustration, we transform the model potential of van Leeuwen and Baerends (which is not a functional derivative) into a semilocal exchange potential that has a parent GGA, yields accurate energies, and is free from the artifacts inherent in existing semilocal potential approximations.

  12. Approaches to defining «financial potential» concept as of economic analysis object

    Directory of Open Access Journals (Sweden)

    O.M. Dzyubenkо

    2017-12-01

    Full Text Available The research analyzes the works of scientists who studied the issues of financial potential as an economic category. Due to analyzing the approaches of the scientists to the concept of "financial potential" the author identifies six approaches to the interpretation of its essence, they are: the totality of the enterprise financial resources, the sources of the enterprise economic activity financing, the enterprise economic activity development, the enterprise financial indicators, the system of enterprise financial management, the enterprise efficiency characteristics. It is established that the financial potential is the multifaceted category that characterizes the financial and economic activity of enterprises. The author's definition of the financial potential in the context of its place in the objects of economic analysis is proposed. It is established that the financial potential is the object of the enterprise economic activity management and is the subject to analytical assessments for establishing its state and directions of development.

  13. Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 zeta Chimeric Antigen Receptor-Modified Effector CD8(+) T Cells

    NARCIS (Netherlands)

    Watanabe, Keisuke; Terakura, Seitaro; Martens, Anton C.; van Meerten, Tom; Uchiyama, Susumu; Imai, Misa; Sakemura, Reona; Goto, Tatsunori; Hanajiri, Ryo; Imahashi, Nobuhiko; Shimada, Kazuyuki; Tomita, Akihiro; Kiyoi, Hitoshi; Nishida, Tetsuya; Naoe, Tomoki; Murata, Makoto

    2015-01-01

    The effectiveness of chimeric Ag receptor (CAR)-transduced T (CAR-T) cells has been attributed to supraphysiological signaling through CARs. Second-and later-generation CARs simultaneously transmit costimulatory signals with CD3 zeta signals upon ligation, but may lead to severe adverse effects

  14. Priority of VHS Development Based in Potential Area using Principal Component Analysis

    Science.gov (United States)

    Meirawan, D.; Ana, A.; Saripudin, S.

    2018-02-01

    The current condition of VHS is still inadequate in quality, quantity and relevance. The purpose of this research is to analyse the development of VHS based on the development of regional potential by using principal component analysis (PCA) in Bandung, Indonesia. This study used descriptive qualitative data analysis using the principle of secondary data reduction component. The method used is Principal Component Analysis (PCA) analysis with Minitab Statistics Software tool. The results of this study indicate the value of the lowest requirement is a priority of the construction of development VHS with a program of majors in accordance with the development of regional potential. Based on the PCA score found that the main priority in the development of VHS in Bandung is in Saguling, which has the lowest PCA value of 416.92 in area 1, Cihampelas with the lowest PCA value in region 2 and Padalarang with the lowest PCA value.

  15. Potential impacts of ENDF/B-V on critical experiment analysis based on ZEBRA-8 criticals

    Energy Technology Data Exchange (ETDEWEB)

    Choong, T S

    1982-06-01

    The ZEBRA-8 series of null-zone measurements featured a different neutron spectrum for each assembly. The experiments were designed for the purpose of basic data testing. The series cover a range of spectra both harder and softer than that for the LMFBR. The potential impacts of the newly released ENDF/BV cross section library on LMFBR critical exeriment analysis are discussed based on analysis of ZEBRA-8 series.

  16. Analysis of Potential Benefits and Costs of Updating the Commercial Building Energy Code in North Dakota

    Energy Technology Data Exchange (ETDEWEB)

    Cort, Katherine A.; Belzer, David B.; Winiarski, David W.; Richman, Eric E.

    2004-04-30

    The state of North Dakota is considering updating its commercial building energy code. This report evaluates the potential costs and benefits to North Dakota residents from updating and requiring compliance with ASHRAE Standard 90.1-2001. Both qualitative and quantitative benefits and costs are assessed in the analysis. Energy and economic impacts are estimated using the Building Loads Analysis and System Thermodynamics (BLAST simulation combined with a Life-cycle Cost (LCC) approach to assess correspodning economic costs and benefits.

  17. Multipoint linkage analysis in X-linked ocular albinism of the Nettleship-Falls type

    NARCIS (Netherlands)

    Bergen, A. A.; Samanns, C.; Schuurman, E. J.; van Osch, L.; van Dorp, D. B.; Pinckers, A. J.; Bakker, E.; Gal, A.; van Ommen, G. J.; Bleeker-Wagemakers, E. M.

    1991-01-01

    An extensive linkage analysis was performed by studying ten Xp22 loci in ten families segregating for X-linked ocular albinism of the Nettleship-Falls type (XOA). Linkage was confirmed between the XOA locus (OA1) and both DXS16 (theta max = 0.10, zeta max = 4.09) and DXS237 (theta max = 0.12, zeta

  18. H{sub 2} EXCITATION STRUCTURE ON THE SIGHTLINES TO {delta} SCORPII AND {zeta} OPHIUCI: FIRST RESULTS FROM THE SUB-ORBITAL LOCAL INTERSTELLAR CLOUD EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    France, Kevin; Nell, Nicholas; Kane, Robert; Green, James C. [Center for Astrophysics and Space Astronomy, University of Colorado, 389 UCB, Boulder, CO 80309 (United States); Burgh, Eric B. [SOFIA/USRA, NASA Ames Research Center, M/S N232-12, Moffett Field, CA 94035 (United States); Beasley, Matthew, E-mail: kevin.france@colorado.edu [Planetary Resources, Inc., 93 S Jackson St 50680, Seattle, WA 98104-2818 (United States)

    2013-07-20

    We present the first science results from the Sub-orbital Local Interstellar Cloud Experiment (SLICE): moderate resolution 1020-1070 A spectroscopy of four sightlines through the local interstellar medium. High signal-to-noise (S/N) spectra of {eta} Uma, {alpha} Vir, {delta} Sco, and {zeta} Oph were obtained during a 2013 April 21 rocket flight. The SLICE observations constrain the density, molecular photoexcitation rates, and physical conditions present in the interstellar material toward {delta} Sco and {zeta} Oph. Our spectra indicate a factor of two lower total N(H{sub 2}) than previously reported for {delta} Sco, which we attribute to higher S/N and better scattered light control in the new SLICE observations. We find N(H{sub 2}) = 1.5 Multiplication-Sign 10{sup 19} cm{sup -2} on the {delta} Sco sightline, with kinetic and excitation temperatures of 67 and 529 K, respectively, and a cloud density of n{sub H} = 56 cm{sup -3}. Our observations of the bulk of the molecular sightline toward {zeta} Oph are consistent with previous measurements (N(H{sub 2}) Almost-Equal-To 3 Multiplication-Sign 10{sup 20} cm{sup -2} at T{sub 01}(H{sub 2}) = 66 K and T{sub exc} = 350 K). However, we detect significantly more rotationally excited H{sub 2} toward {zeta} Oph than previously observed. We infer a cloud density in the rotationally excited component of n{sub H} Almost-Equal-To 7600 cm{sup -3} and suggest that the increased column densities of excited H{sub 2} are a result of the ongoing interaction between {zeta} Oph and its environment; also manifest as the prominent mid-IR bowshock observed by WISE and the presence of vibrationally excited H{sub 2} molecules observed by the Hubble Space Telescope.

  19. ANALYSIS OR THE POTENTIAL SPERM BIOMARKER, SP22, IN HUMAN SEMEN

    Science.gov (United States)

    ANALYSIS OF THE POTENTIAL SPERM BIOMARKER SP22 IN HUMAN SEMEN Rebecca A. Morris Ph.D.1, Gary R. Klinefelter Ph.D.1, Naomi L. Roberts 1, Juan D. Suarez 1, Lillian F. Strader 1, Susan C. Jeffay 1 and Sally D. Perreault Ph.D.1 1 U.S. EPA / ORD / National Health a...

  20. An Analysis of the Educational Potential of Augmented Reality Games for Learning

    NARCIS (Netherlands)

    Schmitz, Birgit; Specht, Marcus; Klemke, Roland

    2013-01-01

    Schmitz, B., Specht, M., & Klemke, R. (2012). An Analysis of the Educational Potential of Augmented Reality Games for Learning. In M. Specht, J. Multisilta, & M. Sharples (Eds.), Proceedings of the 11th World Conference on Mobile and Contextual Learning 2012 (pp. 140-147). October, 16-18, 2012,

  1. Shadow effect on photovoltaic potentiality analysis using 3D city models

    NARCIS (Netherlands)

    Alam, N.; Coors, V.; Zlatanova, S.; Van Oosterom, P.J.M.

    2012-01-01

    Due to global warming, green-house effect and various other drawbacks of existing energy sources, renewable energy like Photovoltaic system is being popular for energy production. The result of photovoltaic potentiality analysis depends on data quality and parameters. Shadow rapidly decreases

  2. Potential analysis reveals changing number of climate states during the last 60 kyr

    Directory of Open Access Journals (Sweden)

    V. N. Livina

    2010-02-01

    Full Text Available We develop and apply a new statistical method of potential analysis for detecting the number of states of a geophysical system, from its recorded time series. Estimation of the degree of a polynomial potential allows us to derive the number of potential wells in a system. The method correctly detects changes in the number of wells in artificial data. In ice-core proxy records of Greenland paleotemperature, a reduction in the number of climate states from two to one is detected sometime prior to the last glacial maximum (LGM, 23–19 kyr BP. This result is also found in analysis of Greenland Ca data. The bifurcation can be interpreted as loss of stability of the warm interstadial state of the Dansgaard-Oeschger (DO events. The proposed method can be applied to a wide range of geophysical time series exhibiting bifurcations.

  3. Parametric sensitivity analysis for the helium dimers on a model potential

    Directory of Open Access Journals (Sweden)

    Nelson Henrique Teixeira Lemes

    2012-01-01

    Full Text Available Potential parameters sensitivity analysis for helium unlike molecules, HeNe, HeAr, HeKr and HeXe is the subject of this work. Number of bound states these rare gas dimers can support, for different angular momentum, will be presented and discussed. The variable phase method, together with the Levinson's theorem, is used to explore the quantum scattering process at very low collision energy using the Tang and Toennies potential. These diatomic dimers can support a bound state even for relative angular momentum equal to five, as in HeXe. Vibrational excited states, with zero angular momentum, are also possible for HeKr and HeXe. Results from sensitive analysis will give acceptable order of magnitude on potentials parameters.

  4. Parametric distribution approach for flow availability in small hydro potential analysis

    Science.gov (United States)

    Abdullah, Samizee; Basri, Mohd Juhari Mat; Jamaluddin, Zahrul Zamri; Azrulhisham, Engku Ahmad; Othman, Jamel

    2016-10-01

    Small hydro system is one of the important sources of renewable energy and it has been recognized worldwide as clean energy sources. Small hydropower generation system uses the potential energy in flowing water to produce electricity is often questionable due to inconsistent and intermittent of power generated. Potential analysis of small hydro system which is mainly dependent on the availability of water requires the knowledge of water flow or stream flow distribution. This paper presented the possibility of applying Pearson system for stream flow availability distribution approximation in the small hydro system. By considering the stochastic nature of stream flow, the Pearson parametric distribution approximation was computed based on the significant characteristic of Pearson system applying direct correlation between the first four statistical moments of the distribution. The advantage of applying various statistical moments in small hydro potential analysis will have the ability to analyze the variation shapes of stream flow distribution.

  5. Preliminary phytochemical screening, Antibacterial potential and GC-MS analysis of two medicinal plant extracts.

    Science.gov (United States)

    Vijayaram, Seerangaraj; Kannan, Suruli; Saravanan, Konda Mani; Vasantharaj, Seerangaraj; Sathiyavimal, Selvam; P, Palanisamy Senthilkumar

    2016-05-01

    The presence study was aimed to catalyze the primary metabolites and their confirmation by using GC-MS analysis and antibacterial potential of leaf extract of two important medicinal plant viz., Eucalyptus and Azadirachta indica. The antibacterial potential of the methanol leaf extract of the studied species was tested against Escherichia coli, Pseudomonas aeruginosa, Klebsiellap neumoniae, Streptococcus pyogens, Staphylococcus aureus using by agar well diffusion method. The higher zone of inhibition (16mm) was observed against the bacterium Pseudomonas aeruginosa at 100μl concentration of methanol leaf extract. Preliminary phytochemical analysis of studied species shows that presence of phytochemical compounds like steroids, phenolic compounds and flavonoids. GC-MS analysis confirms the occurrence of 20 different compounds in the methanol leaf extract of the both studied species.

  6. Analysis of Wind Data, Calculation of Energy Yield Potential, and Micrositing Application with WAsP

    Directory of Open Access Journals (Sweden)

    Fatih Topaloğlu

    2018-01-01

    Full Text Available The parameters required for building a wind power plant have been calculated using the fuzzy logic method by means of Wind Atlas Analysis and Application Program (WAsP in this study. Overall objectives of the program include analysis of raw data, evaluation of wind and climate, construction of a wind atlas, and estimation of wind power potential. With the analysis performed in the application, the average wind velocity, average power density, energy potential from micrositing, capacity factor, unit cost price, and period of redemption have been calculated, which are needed by the project developer during the decision-making stage and intended to be used as the input unit in the fuzzy logic-based system designed. It is aimed at processing the parameters calculated by the designed fuzzy logic-based decision-making system at the rule base and generating a compatibility factor that will allow for making the final decision in building wind power plants.

  7. Neural network approach in multichannel auditory event-related potential analysis.

    Science.gov (United States)

    Wu, F Y; Slater, J D; Ramsay, R E

    1994-04-01

    Even though there are presently no clearly defined criteria for the assessment of P300 event-related potential (ERP) abnormality, it is strongly indicated through statistical analysis that such criteria exist for classifying control subjects and patients with diseases resulting in neuropsychological impairment such as multiple sclerosis (MS). We have demonstrated the feasibility of artificial neural network (ANN) methods in classifying ERP waveforms measured at a single channel (Cz) from control subjects and MS patients. In this paper, we report the results of multichannel ERP analysis and a modified network analysis methodology to enhance automation of the classification rule extraction process. The proposed methodology significantly reduces the work of statistical analysis. It also helps to standardize the criteria of P300 ERP assessment and facilitate the computer-aided analysis on neuropsychological functions.

  8. An evaluation of domestic solar energy potential in Taiwan incorporating land use analysis

    International Nuclear Information System (INIS)

    Yue, Cheng-Dar; Huang, Guo-Rong

    2011-01-01

    Solar energy is widely regarded as a major renewable energy source, which in future energy systems will be able to contribute to the security of energy supply and the reduction of CO 2 emissions. This study combined an evaluation of solar energy resources in Taiwan with land use analysis, which allows the potentials and restrictions of solar energy exploitation resulting from local land use conditions to be considered. The findings unveiled in this study indicate that photovoltaic electricity generation and solar water heating have the potential of producing 36.1 and 10.2 TWh of electricity and thermal energy annually in Taiwan, accounting for 16.3% and 127.5% of the total domestic consumption of electricity and energy for household water heating in 2009, respectively. However, the exploited solar photovoltaic power generation in 2009 accounted for only 0.02% of total potential in Taiwan, while the exploited solar water heating accounted for 11.6% of total potential. Market price and investment incentive are the dominant factors that affect market acceptance of solar energy installation in Taiwan. The administrative barriers to the purchase and transmission of electricity generated from renewable energy sources have to be removed before the potential contribution of solar energy can be realized. - Highlights: ► Solar PV and solar water heating have a vital energy potential. ► Solar PV has an essential potential in CO 2 reduction. ► Investment incentives dominate market acceptance of solar energy. ► Appropriate urban building bulk facilitates energy autonomy using solar energy. ► Land use analysis is a viable tool to evaluate solar energy potential.

  9. Geospatial Analysis of Near-Term Technical Potential of BECCS in the U.S.

    Science.gov (United States)

    Baik, E.; Sanchez, D.; Turner, P. A.; Mach, K. J.; Field, C. B.; Benson, S. M.

    2017-12-01

    Atmospheric carbon dioxide (CO2) removal using bioenergy with carbon capture and storage (BECCS) is crucial for achieving stringent climate change mitigation targets. To date, previous work discussing the feasibility of BECCS has largely focused on land availability and bioenergy potential, while CCS components - including capacity, injectivity, and location of potential storage sites - have not been thoroughly considered in the context of BECCS. A high-resolution geospatial analysis of both biomass production and potential geologic storage sites is conducted to consider the near-term deployment potential of BECCS in the U.S. The analysis quantifies the overlap between the biomass resource and CO2 storage locations within the context of storage capacity and injectivity. This analysis leverages county-level biomass production data from the U.S. Department of Energy's Billion Ton Report alongside potential CO2 geologic storage sites as provided by the USGS Assessment of Geologic Carbon Dioxide Storage Resources. Various types of lignocellulosic biomass (agricultural residues, dedicated energy crops, and woody biomass) result in a potential 370-400 Mt CO2 /yr of negative emissions in 2020. Of that CO2, only 30-31% of the produced biomass (110-120 Mt CO2 /yr) is co-located with a potential storage site. While large potential exists, there would need to be more than 250 50-MW biomass power plants fitted with CCS to capture all the co-located CO2 capacity in 2020. Neither absolute injectivity nor absolute storage capacity is likely to limit BECCS, but the results show regional capacity and injectivity constraints in the U.S. that had not been identified in previous BECCS analysis studies. The state of Illinois, the Gulf region, and western North Dakota emerge as the best locations for near-term deployment of BECCS with abundant biomass, sufficient storage capacity and injectivity, and the co-location of the two resources. Future studies assessing BECCS potential should

  10. Finite temperature Casimir energy in closed rectangular cavities: a rigorous derivation based on a zeta function technique

    International Nuclear Information System (INIS)

    Lim, S C; Teo, L P

    2007-01-01

    We derive rigorously explicit formulae of the Casimir free energy at finite temperature for massless scalar field and electromagnetic field confined in a closed rectangular cavity with different boundary conditions by a zeta regularization method. We study both the low and high temperature expansions of the free energy. In each case, we write the free energy as a sum of a polynomial in temperature plus exponentially decay terms. We show that the free energy is always a decreasing function of temperature. In the cases of massless scalar field with the Dirichlet boundary condition and electromagnetic field, the zero temperature Casimir free energy might be positive. In each of these cases, there is a unique transition temperature (as a function of the side lengths of the cavity) where the Casimir energy changes from positive to negative. When the space dimension is equal to two and three, we show graphically the dependence of this transition temperature on the side lengths of the cavity. Finally we also show that we can obtain the results for a non-closed rectangular cavity by letting the size of some directions of a closed cavity go to infinity, and we find that these results agree with the usual integration prescription adopted by other authors

  11. The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells.

    Directory of Open Access Journals (Sweden)

    Gunter Rappl

    Full Text Available Adoptive therapy of malignant diseases with tumor-specific cytotoxic T cells showed remarkable efficacy in recent trials. Repetitive T cell receptor (TCR engagement of target antigen, however, inevitably ends up in hypo-responsive cells with terminally differentiated KLRG-1(+ CD57(+ CD7(- phenotype limiting their therapeutic efficacy. We here revealed that hypo-responsiveness of CMV-specific late-stage CD8(+ T cells is due to reduced TCR synapse formation compared to younger cells. Membrane anchoring of TCR components contributes to T cell hypo-responsiveness since dislocation of galectin-3 from the synapse by swainsonine restored both TCR synapse formation and T cell response. Transgenic expression of a CD3-zeta signaling chimeric antigen receptor (CAR recovered hypo-responsive T cells to full effector functions indicating that the defect is restricted to TCR membrane components while synapse formation of the transgenic CAR was not blocked. CAR engineered late-stage T cells released cytokines and mediated redirected cytotoxicity as efficiently as younger effector T cells. Our data provide a rationale for TCR independent, CAR mediated activation in the adoptive cell therapy to avoid hypo-responsiveness of late-stage T cells upon repetitive antigen encounter.

  12. Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.

    Directory of Open Access Journals (Sweden)

    Gary P Brennan

    Full Text Available 14-3-3 proteins are ubiquitous molecular chaperones that are abundantly expressed in the brain where they regulate cell functions including metabolism, the cell cycle and apoptosis. Brain levels of several 14-3-3 isoforms are altered in diseases of the nervous system, including epilepsy. The 14-3-3 zeta (ζ isoform has been linked to endoplasmic reticulum (ER function in neurons, with reduced levels provoking ER stress and increasing vulnerability to excitotoxic injury. Here we report that transgenic overexpression of 14-3-3ζ in mice results in selective changes to the unfolded protein response pathway in the hippocampus, including down-regulation of glucose-regulated proteins 78 and 94, activating transcription factors 4 and 6, and Xbp1 splicing. No differences were found between wild-type mice and transgenic mice for levels of other 14-3-3 isoforms or various other 14-3-3 binding proteins. 14-3-3ζ overexpressing mice were potently protected against cell death caused by intracerebroventricular injection of the ER stressor tunicamycin. 14-3-3ζ overexpressing mice were also potently protected against neuronal death caused by prolonged seizures. These studies demonstrate that increased 14-3-3ζ levels protect against ER stress and seizure-damage despite down-regulation of the unfolded protein response. Delivery of 14-3-3ζ may protect against pathologic changes resulting from prolonged or repeated seizures or where injuries provoke ER stress.

  13. The Potential for Renewable Energy Development to Benefit Restoration of the Salton Sea. Analysis of Technical and Market Potential

    Energy Technology Data Exchange (ETDEWEB)

    Gagne, Douglas [National Renewable Energy Lab. (NREL), Golden, CO (United States); Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Oakleaf, Brett [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hurlbut, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Akar, Sertac [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wall, Anna [National Renewable Energy Lab. (NREL), Golden, CO (United States); Turchi, Craig [National Renewable Energy Lab. (NREL), Golden, CO (United States); Pienkos, Philip [National Renewable Energy Lab. (NREL), Golden, CO (United States); Melius, Jennifer [National Renewable Energy Lab. (NREL), Golden, CO (United States); Melaina, Marc [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-11-01

    This report summarizes the potential for renewable energy development in the Salton Sea region, as well as the potential for revenues from this development to contribute financially to Salton Sea restoration costs. It considers solar, geothermal, biofuels or nutraceutical production from algae pond cultivation, desalination using renewable energy, and mineral recovery from geothermal fluids.


  14. Lessons learnt from a sectoral analysis of greenhouse gas mitigation potential in the Balkans

    International Nuclear Information System (INIS)

    Georgopoulou, E.; Mirasgedis, S.; Sarafidis, Y.; Gakis, N.; Hontou, V.; Lalas, D.P.; Steiner, D.; Tuerk, A.; Fruhmann, C.; Pucker, J.

    2015-01-01

    Balkan countries in the process of joining the European Union shall adopt greenhouse gas emissions reduction targets and implement appropriate mitigation policies and measures. This paper presents a simplified methodological framework based on marginal abatement cost curves for estimating the technical and economic mitigation potential at sectoral level (buildings and road transport) in selected Balkan countries. The results of the analysis provide to decision makers useful information regarding the availability of background data, the potential for setting ambitious mitigation targets, and detailed tools for assisting the selection of policies and measures to meet these targets. The analysis performed shows that a significant part of the greenhouse gas emissions abatement potential can be achieved through win–win measures. The incorporation of environmental externalities associated with these interventions, estimated through benefits transfer, further improves the economic performance of these measures, especially in the buildings sector. Moreover, the implementation of these measures is shown to result in positive macroeconomic effects through increases in GDP (gross domestic product) and creation of new jobs. Finally, the rebound effect may restrict the estimated greenhouse gas emission reductions in the buildings of the countries examined due to the low energy performance of the existing building stock. - Highlights: • Analysis of the technical and economic GHG mitigation potential in western Balkans. • Marginal abatement cost curves highlight several win–win interventions. • Incorporation of environmental benefits improves the performance of measures. • Mitigation measures result in significant positive macroeconomic effects. • The investment costs and the rebound effect may influence measures' effectiveness.

  15. Chemical phase analysis of seed mediated synthesized anisotropic silver nanoparticles

    International Nuclear Information System (INIS)

    Bharti, Amardeep; Goyal, Navdeep; Singh, Suman; Singla, M. L.

    2015-01-01

    Noble-metal nanoparticles are of great interest because of its broad applications almost in every stream (i.e. biology, chemistry and engineering) due to their unique size/shape dependant properties. In this paper, chemical phase of seed mediated synthesized anisotropic silver nanoparticle (AgNPs) has been investigated via fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). These nanaoparticles were synthesized by seed-growth method controlled by urea and dextrose results to highly stable 12-20 nm particle size revealed by zeta potential and transmission electron microscopy (TEM)

  16. Improvement potential of a real geothermal power plant using advanced exergy analysis

    International Nuclear Information System (INIS)

    Gökgedik, Harun; Yürüsoy, Muhammet; Keçebaş, Ali

    2016-01-01

    The main purpose of this paper is to quantitatively evaluate thermodynamic performance of a geothermal power plant (GPP) from potential for improvement point of view. Thus, sources of inefficiency and irreversibilities can be determined through exergy analysis. The advanced exergy analysis is more appropriate to determine real potential for thermodynamic improvements of the system by splitting exergy destruction into unavoidable and avoidable portions. The performance critical components and the potential for exergy efficiency improvement of a GPP were determined by means of the advanced exergy analysis. This plant is the Bereket GPP in Denizli/Turkey as a current operating system. The results show that the avoidable portion of exergy destruction in all components except for the turbines is higher than the unavoidable value. Therefore, much can be made to lessen the irreversibilities for components of the Bereket GPP. The total exergy efficiency of the system is found to be 9.60%. Its efficiency can be increased up to 15.40% by making improvements in the overall components. Although the heat exchangers had lower exergy and modified exergy efficiencies, their exergy improvement potentials were high. Finally, in the plant, the old technology is believed to be one of the main reasons for low efficiencies. - Highlights: • Evaluation of potential for improvement of a GPP using advanced exergy analysis. • Efficiency can be increased up to 15.40% by making improvements in the components. • Heat exchangers are the highest avoidable values, making them the least efficient components in plant. • The main reasons for low efficiencies are believed to be the old technology.

  17. Export Potential of the Enterprise: Essence and Methodological Bases of the Analysis

    Directory of Open Access Journals (Sweden)

    Melnyk Olga G.

    2017-03-01

    Full Text Available The article considers theoretical and methodological aspects of the analysis of the enterprise’s export potential and the methodological basis for its measurement. Analyzing and summarizing scientific works on the problem, the views of researchers on the definition of the concept of “export potential of the enterprise” are systematized. The article considers the economic content of the enterprise’s export potential from the standpoint of the system-structural approach defining it as a complex systemic formation of interrelated and interacting elements of economic and non-economic origin, internal and external action. It is found out that in the international economic space the export potential of the enterprise acquires new qualitative features reflecting not just the resource potential of the national economic entity but also the needs and interests of foreign countries and their economic agents. It is identified that the functional role of the export potential is to implement the targets of the foreign economic activity of the enterprise. The nature of these targets can be different and is formed on the principle of ensuring the needs of external markets. The level of satisfaction of these needs by an individual enterprise can be evaluated through such indicators as the volume of exports, the quality of exported products, the level of export diversification, which determine the result of the export activity and in relation to its purpose serve as a criterion of the efficiency of the enterprise’s export potential. As a result of the study, the components of the export potential of the enterprise are singled out, and a model of their interrelationships is presented. The prospects of the research are connected with branch aspects of the formation of the enterprise’s export potential allowing to highlight its structural elements and directions of development.

  18. A preliminary analysis of the risk of transporting nuclear waste to potential candidate commercial repository sites

    International Nuclear Information System (INIS)

    Madsen, M.M.

    1984-01-01

    In accordance with the provisions of the Nuclear Waste Policy Act of 1982, environmental assessments for potential candidate sites are required to provide a basis for selection of the first site for disposal of commercial radioactive waste in deep geologic repositories. A preliminary analysis of the impacts of transportation for each of the five potential sites will be described. Transportation was assumed to be entirely by truck or entirely by rail in order to obtain bounding impacts. This paper presents both radiological and nonradiological risks for the once-through fuel cycle

  19. Hypophosphatemia. From retrospective analysis to the analysis of the potential role of phosphatemia in panic disorders

    Directory of Open Access Journals (Sweden)

    Alessandro Riccardi

    2010-09-01

    Full Text Available The detection of a low serum phosphate level is not unusual in an Emergency Department, especially in clinical conditions linked to hyperventilation and subsequent respiratory alkalosis, asthma, sepsis, severe pain, anxiety. Symptoms of hypophosphatemia are typically not specific when the imbalance is not particularly severe, but if hyphophosphatemia does not resolve rhabdomyolisis, hemolysis, decreased tissue oxygenation and respiratory failure can be observed. Only recently some authors have pointed out that the level of serum phosphate in patient with anxiety and panic disorders can give information on the severity of the attacks as well on the clinical course of the disease. In a retrospective analysis on 599 case of hypophosphatemia observed in our ED, the percentage of case of panic disorders was particularly high among patients with lower phosphatemia. Therefore, we decided to examine this aspect closely, assessing if the determination of serum phosphate could be useful in the management of panic attacks at first approach in emergency room. Our observation are consistent with the statement that hypophosphatemia is one of the main clinical aspect of panic attack, and strongly support the hypothesis that hypophosphatemia correlates with the most severe symptoms of panic attack and should be itself considered as one of the most important aspect of this syndrome. Serum phosphate levels appear to mirror its clinical course, and can be used in the clinical setting of an Emergency Department, for the confirmation of a diagnosis of anxiety-panic disorder and as marker of the response to therapy

  20. A Principal Component Analysis/Fuzzy Comprehensive Evaluation for Rockburst Potential in Kimberlite

    Science.gov (United States)

    Pu, Yuanyuan; Apel, Derek; Xu, Huawei

    2018-02-01

    Kimberlite is an igneous rock which sometimes bears diamonds. Most of the diamonds mined in the world today are found in kimberlite ores. Burst potential in kimberlite has not been investigated, because kimberlite is mostly mined using open-pit mining, which poses very little threat of rock bursting. However, as the mining depth keeps increasing, the mines convert to underground mining methods, which can pose a threat of rock bursting in kimberlite. This paper focuses on the burst potential of kimberlite at a diamond mine in northern Canada. A combined model with the methods of principal component analysis (PCA) and fuzzy comprehensive evaluation (FCE) is developed to process data from 12 different locations in kimberlite pipes. Based on calculated 12 fuzzy evaluation vectors, 8 locations show a moderate burst potential, 2 locations show no burst potential, and 2 locations show strong and violent burst potential, respectively. Using statistical principles, a Mahalanobis distance is adopted to build a comprehensive fuzzy evaluation vector for the whole mine and the final evaluation for burst potential is moderate, which is verified by a practical rockbursting situation at mine site.

  1. GIS-based bivariate statistical techniques for groundwater potential analysis (an example of Iran)

    Science.gov (United States)

    Haghizadeh, Ali; Moghaddam, Davoud Davoudi; Pourghasemi, Hamid Reza

    2017-12-01

    Groundwater potential analysis prepares better comprehension of hydrological settings of different regions. This study shows the potency of two GIS-based data driven bivariate techniques namely statistical index (SI) and Dempster-Shafer theory (DST) to analyze groundwater potential in Broujerd region of Iran. The research was done using 11 groundwater conditioning factors and 496 spring positions. Based on the ground water potential maps (GPMs) of SI and DST methods, 24.22% and 23.74% of the study area is covered by poor zone of groundwater potential, and 43.93% and 36.3% of Broujerd region is covered by good and very good potential zones, respectively. The validation of outcomes displayed that area under the curve (AUC) of SI and DST techniques are 81.23% and 79.41%, respectively, which shows SI method has slightly a better performance than the DST technique. Therefore, SI and DST methods are advantageous to analyze groundwater capacity and scrutinize the complicated relation between groundwater occurrence and groundwater conditioning factors, which permits investigation of both systemic and stochastic uncertainty. Finally, it can be realized that these techniques are very beneficial for groundwater potential analyzing and can be practical for water-resource management experts.

  2. Identification and analysis of potential targets in Streptococcus sanguinis using computer aided protein data analysis.

    Science.gov (United States)

    Chowdhury, Md Rabiul Hossain; Bhuiyan, Md IqbalKaiser; Saha, Ayan; Mosleh, Ivan Mhai; Mondol, Sobuj; Ahmed, C M Sabbir

    2014-01-01

    Streptococcus sanguinis is a Gram-positive, facultative aerobic bacterium that is a member of the viridans streptococcus group. It is found in human mouths in dental plaque, which accounts for both dental cavities and bacterial endocarditis, and which entails a mortality rate of 25%. Although a range of remedial mediators have been found to control this organism, the effectiveness of agents such as penicillin, amoxicillin, trimethoprim-sulfamethoxazole, and erythromycin, was observed. The emphasis of this investigation was on finding substitute and efficient remedial approaches for the total destruction of this bacterium. In this computational study, various databases and online software were used to ascertain some specific targets of S. sanguinis. Particularly, the Kyoto Encyclopedia of Genes and Genomes databases were applied to determine human nonhomologous proteins, as well as the metabolic pathways involved with those proteins. Different software such as Phyre2, CastP, DoGSiteScorer, the Protein Function Predictor server, and STRING were utilized to evaluate the probable active drug binding site with its known function and protein-protein interaction. In this study, among 218 essential proteins of this pathogenic bacterium, 81 nonhomologous proteins were accrued, and 15 proteins that are unique in several metabolic pathways of S. sanguinis were isolated through metabolic pathway analysis. Furthermore, four essentially membrane-bound unique proteins that are involved in distinct metabolic pathways were revealed by this research. Active sites and druggable pockets of these selected proteins were investigated with bioinformatic techniques. In addition, this study also mentions the activity of those proteins, as well as their interactions with the other proteins. Our findings helped to identify the type of protein to be considered as an efficient drug target. This study will pave the way for researchers to develop and discover more effective and specific

  3. Identification and analysis of potential targets in Streptococcus sanguinis using computer aided protein data analysis

    Science.gov (United States)

    Chowdhury, Md Rabiul Hossain; Bhuiyan, Md IqbalKaiser; Saha, Ayan; Mosleh, Ivan MHAI; Mondol, Sobuj; Ahmed, C M Sabbir

    2014-01-01

    Purpose Streptococcus sanguinis is a Gram-positive, facultative aerobic bacterium that is a member of the viridans streptococcus group. It is found in human mouths in dental plaque, which accounts for both dental cavities and bacterial endocarditis, and which entails a mortality rate of 25%. Although a range of remedial mediators have been found to control this organism, the effectiveness of agents such as penicillin, amoxicillin, trimethoprim–sulfamethoxazole, and erythromycin, was observed. The emphasis of this investigation was on finding substitute and efficient remedial approaches for the total destruction of this bacterium. Materials and methods In this computational study, various databases and online software were used to ascertain some specific targets of S. sanguinis. Particularly, the Kyoto Encyclopedia of Genes and Genomes databases were applied to determine human nonhomologous proteins, as well as the metabolic pathways involved with those proteins. Different software such as Phyre2, CastP, DoGSiteScorer, the Protein Function Predictor server, and STRING were utilized to evaluate the probable active drug binding site with its known function and protein–protein interaction. Results In this study, among 218 essential proteins of this pathogenic bacterium, 81 nonhomologous proteins were accrued, and 15 proteins that are unique in several metabolic pathways of S. sanguinis were isolated through metabolic pathway analysis. Furthermore, four essentially membrane-bound unique proteins that are involved in distinct metabolic pathways were revealed by this research. Active sites and druggable pockets of these selected proteins were investigated with bioinformatic techniques. In addition, this study also mentions the activity of those proteins, as well as their interactions with the other proteins. Conclusion Our findings helped to identify the type of protein to be considered as an efficient drug target. This study will pave the way for researchers to

  4. The analysis of the wind potential in selected locations in the southeastern Poland

    Directory of Open Access Journals (Sweden)

    Sornek Krzysztof

    2017-01-01

    Full Text Available This paper shows the results of analysis of the wind potential in selected locations in the southern Poland (placed in the Małopolskie, Świętokrzyskie and Podkarpackie Voivodships. The measurements and analysis of the wind resources in potential locations of the wind turbines are important part of the investment process. The statistical analysis involves the creation of histograms (e.g. histogram of the wind speed and direction and fitting those histograms to theoretical distributions (e.g. Weilbull distributions of wind speed. Such analysis has been described and conducted using measurement data for four selected locations. Basis on the conducted analysis, the economy efficiency and environmental impact of wind turbine operation has been estimated. Three market available wind turbines have been included to calculate NPV, IRR and SPBT indicators. Then, the avoided emissions of CO2, NOx, SO2 and dust have been calculated. There were also conducted some calculation using TRNSYS simulation software. The results of simulations have been compared with measurement data and the level of convergence have been found.

  5. Analysis of Renewable Energy Potential on U. S. National Forest Lands

    Energy Technology Data Exchange (ETDEWEB)

    Zvolanek, E. [Environmental Science Division; Kuiper, J. [Environmental Science Division; Carr, A. [Environmental Science Division; Hlava, K.

    2013-12-13

    In 2005, the National Renewable Energy Laboratory (NREL) completed an assessment of the potential for solar and wind energy development on National Forest System (NFS) public lands managed by the US Department of Agriculture, U.S. Forest Service (USFS). This report provides an update of the analysis in the NREL report, and extends the analysis with additional siting factors for solar and wind energy. It also expands the scope to biomass and geothermal energy resources. Hydropower is acknowledged as another major renewable energy source on NFS lands; however, it was not analyzed in this project primarily because of the substantially different analysis that would be needed to identify suitable locations. Details about each renewable energy production technology included in the study are provided following the report introduction, including how each resource is converted to electrical power, and examples of existing power plants. The analysis approach was to use current and available Geographic Information System (GIS) data to map the distribution of the subject renewable energy resources, major siting factors, and NFS lands. For each major category of renewable energy power production, a set of siting factors were determined, including minimum levels for the renewable energy resources, and details for each of the other siting factors. Phase 1 of the analysis focused on replicating and updating the 2005 NREL analysis, and Phase 2 introduced additional siting factors and energy resources. Source data were converted to a cell-based format that helped create composite maps of locations meeting all the siting criteria. Acreages and potential power production levels for NFS units were tabulated and are presented throughout this report and the accompanying files. NFS units in the southwest United States were found to have the most potentially suitable land for concentrating solar power (CSP), especially in Arizona and New Mexico. In total, about 136,032 acres of NFS lands

  6. GENOMIC ANALYSIS OF PLANT-ASSOCIATED BACTERIA AND THEIR POTENTIAL IN ENHANCING PHYTOREMEDIATION EFFICIENCY

    Directory of Open Access Journals (Sweden)

    Artur Piński

    2017-07-01

    Full Text Available Phytoremediation is an emerging technology that uses plants in order to cleanup pollutants including xenobiotics and heavy metals from soil, water and air. Inoculation of plants with plant growth promoting endophytic and rhizospheric bacteria can enhance efficiency of phytoremediation. Genomic analysis of four plant-associated strains belonging to the Stenotrophomonas maltophilia species revealed the presence of genes encoding proteins involved in plant growth promotion, biocontrol of phytopathogens, biodegradation of xenobiotics, heavy metals resistance and plant-bacteria-environment interaction. The results of this analysis suggest great potential of bacteria belonging to Stenotrophomonas maltophilia species in enhancing phytoremediation efficiency.

  7. Phytoremediation potential of Arabidopsis with reference to acrylamide and microarray analysis of acrylamide-response genes.

    Science.gov (United States)

    Gao, Jian-Jie; Peng, Ri-He; Zhu, Bo; Wang, Bo; Wang, Li-Juan; Xu, Jing; Sun, Miao; Yao, Quan-Hong

    2015-10-01

    Acrylamide (ACR) is a widely used industrial chemical. However, it is a dangerous compound because it showed neurotoxic effects in humans and act as reproductive toxicant and carcinogen in many animal species. In the environment, acrylamide has high soil mobility and may travel via groundwater. Phytoremediation is an effective method to remove the environmental pollutants, but the mechanism of plant response to acrylamide remains unknown. With the purpose of assessing remediation potentials of plants for acrylamide, we have examined acrylamide uptake by the model plant Arabidopsis grown on contaminated substrates with high performance liquid chromatography (HPLC) analysis. The result revealed that acrylamide could be absorbed and degraded by Arabidopsis. Further microarray analysis showed that 527 transcripts were up-regulated within 2-days under acrylamide exposure condition. We have found many potential acrylamide-induced genes playing a major role in plant metabolism and phytoremediation. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Analysis of the potential for hydrogen production in the province of Cordoba, Argentina, from wind resources

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, C.R.; Santa Cruz, R.; Aisa, S. [Universidad Empresarial Siglo 21, Monsenor Pablo Cabrera s/n calle, 5000 Cordoba (Argentina); Riso, M.; Jimenez Yob, G.; Ottogalli, R. [Subsecretaria de Infraestructuras y Programas, Ministerio de Obras y Servicios Publicos del Gobierno de la Provincia de Cordoba, Av. Poeta Lugones 12, 2do. Piso, 5000 Cordoba (Argentina); Jeandrevin, G. [Instituto Universitario Aeronautico, Avenida Fuerza Aerea km 6 1/2, 5022 Cordoba (Argentina); Leiva, E.P.M. [INFIQC, Unidad de Matematica y Fisica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre s/n, 5010 Cordoba (Argentina)

    2010-06-15

    The potential for hydrogen production from wind resources in the province of Cordoba, second consumer of fossil fuels for transportation in Argentina, is analyzed. Three aspects of the problem are considered: the evaluation of the hydrogen resource from wind power, the analysis of the production costs via electrolysis and the annual requirements of wind energy to generate hydrogen to fuel the vehicular transport of the province. Different scenarios were considered, including pure hydrogen as well as the so-called CNG plus, where hydrogen is mixed with compressed natural gas in a 20% V/V dilution of the former. The potential for hydrogen production from wind resources is analyzed for each department of the province, excluding those regions not suited for wind farms. The analysis takes into account the efficiency of the electrolyzer and the capacity factor of the wind power system. It is concluded that the automotive transportation could be supplied by hydrogen stemming from wind resources via electrolysis. (author)

  9. Preclosure radiological safety analysis for accident conditions of the potential Yucca Mountain Repository: Underground facilities

    International Nuclear Information System (INIS)

    Ma, C.W.; Sit, R.C.; Zavoshy, S.J.; Jardine, L.J.; Laub, T.W.

    1992-06-01

    This preliminary preclosure radiological safety analysis assesses the scenarios, probabilities, and potential radiological consequences associated with postulated accidents in the underground facility of the potential Yucca Mountain repository. The analysis follows a probabilistic-risk-assessment approach. Twenty-one event trees resulting in 129 accident scenarios are developed. Most of the scenarios have estimated annual probabilities ranging from 10 -11 /yr to 10 -5 /yr. The study identifies 33 scenarios that could result in offsite doses over 50 mrem and that have annual probabilities greater than 10 -9 /yr. The largest offsite dose is calculated to be 220 mrem, which is less than the 500 mrem value used to define items important to safety in 10 CFR 60. The study does not address an estimate of uncertainties, therefore conclusions or decisions made as a result of this report should be made with caution

  10. A perspective on electric vehicles: cost-benefit analysis and potential demand

    International Nuclear Information System (INIS)

    2011-01-01

    This report proposes some quantitative elements to assess the large scale diffusion of electric vehicles and analyse the potential demand for such vehicles. The first part proposes a cost-benefit analysis of the development of electric vehicles based on estimated costs and expected benefits by 2020. It addresses the following issues: framework and hypothesis, total cost of ownership, costs related to the deployment of a network of recharging infrastructures, assessment of external costs, and comparative cost-benefit analysis of electric vehicles. In the second part, the authors aim at identifying a potential demand for electric vehicles from the 2008 French national transport displacement survey (ENTD 2008) which provides recent data on the mobility of the French population

  11. Identification and analysis of potential targets in Streptococcus sanguinis using computer aided protein data analysis

    Directory of Open Access Journals (Sweden)

    Chowdhury MRH

    2014-11-01

    Full Text Available Md Rabiul Hossain Chowdhury,1 Md IqbalKaiser Bhuiyan,2 Ayan Saha,2 Ivan MHAI Mosleh,2 Sobuj Mondol,2 C M Sabbir Ahmed3 1Department of Pharmacy, University of Science and Technology Chittagong, Chittagong, Bangladesh; 2Department of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong, Bangladesh; 3Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh Purpose: Streptococcus sanguinis is a Gram-positive, facultative aerobic bacterium that is a member of the viridans streptococcus group. It is found in human mouths in dental plaque, which accounts for both dental cavities and bacterial endocarditis, and which entails a mortality rate of 25%. Although a range of remedial mediators have been found to control this organism, the effectiveness of agents such as penicillin, amoxicillin, trimethoprim–sulfamethoxazole, and erythromycin, was observed. The emphasis of this investigation was on finding substitute and efficient remedial approaches for the total destruction of this bacterium. Materials and methods: In this computational study, various databases and online software were used to ascertain some specific targets of S. sanguinis. Particularly, the Kyoto Encyclopedia of Genes and Genomes databases were applied to determine human nonhomologous proteins, as well as the metabolic pathways involved with those proteins. Different software such as Phyre2, CastP, DoGSiteScorer, the Protein Function Predictor server, and STRING were utilized to evaluate the probable active drug binding site with its known function and protein–protein interaction. Results: In this study, among 218 essential proteins of this pathogenic bacterium, 81 nonhomologous proteins were accrued, and 15 proteins that are unique in several metabolic pathways of S. sanguinis were isolated through metabolic pathway analysis. Furthermore, four essentially membrane-bound unique proteins that are involved in distinct metabolic

  12. Analysis of wind energy potential for agriculture pump in mountain area Aceh Besar

    Science.gov (United States)

    Syuhada, Ahmad; Maulana, Muhammad Ilham; Fuadi, Zahrul

    2017-06-01

    In this study, the potential of wind power for agricultural pump driver in Saree mountainous area of Aceh Besar is analyzed. It is found that the average usable wind speed is 6.41 m/s, which is potential to produce 893.96 Watt of electricity with the wind turbine rotor diameter of 3 m. This energy can be used to drive up to 614 Watt of water pump with static head of 20 m to irrigate 19 hectare of land, 7 hours a day. HOMER analysis indicated the lowest simulated NPC value of USD 10.028 with CoE of USD 0.717 kWh. It is also indicated that the wind has potential to produce 3452 kWh/year with lifetime of 15 years.

  13. Wavelet analysis as a tool to characteriseand remove environmental noisefrom self-potential time series

    OpenAIRE

    Chianese, D.; Colangelo, G.; D'Emilio, M.; Lanfredi, M.; Lapenna, V.; Ragosta, M.; Macchiato, M. F.

    2004-01-01

    Multiresolution wavelet analysis of self-potential signals and rainfall levels is performed for extracting fluctuations in electrical signals, which might be addressed to meteorological variability. In the time-scale domain of the wavelet transform, rain data are used as markers to single out those wavelet coefficients of the electric signal which can be considered relevant to the environmental disturbance. Then these coefficients are filtered out and the signal is recovered by anti...

  14. Strategic Analysis of How to Maximize the Earning Potential of Widgets

    OpenAIRE

    Carrigan, Jonathan; Zandstra, André

    2008-01-01

    This paper presents an analysis and recommendations for maximizing the earning potential of CBC widgets. Theoretical concepts, such as the Customer Value Model, Roger's Model of Adoption and viral marketing are used to identify ways to grow widget adoption and encourage viral distribution as a means to increase impressions available for sale to advertisers. The paper explores trends in Internet usage and advertising, with a focus on defining best practices that can be applied broadly to all w...

  15. Integral Hellmann--Feynman analysis of nonisoelectronic processes and the determination of local ionization potentials

    International Nuclear Information System (INIS)

    Simons, G.

    1975-01-01

    The integral Hellmann--Feynmann theorem is extended to apply to nonisoelectronic processes. A local ionization potential formula is proposed, and test calculations on three different approximate helium wavefunctions are reported which suggest that it may be numerically superior to the standard difference of expectation values. Arguments for the physical utility of the new concept are presented, and an integral Hellmann--Feynman analysis of transition energies is begun

  16. SECTIONAL ANALYSIS OF POTENTIAL CONSUMERS OF RETAIL TRADING SERVICES OF POPULATION OF IZHEVSK

    Directory of Open Access Journals (Sweden)

    N.G. Sokolova

    2009-06-01

    Full Text Available Social trends and preferences of potential consumer of retail services when selling food products in Izhevsk, based on the data of marketing research are being studied. Sectional analysis for the given market is held. The trend of selected market section is described. The article contains the calculation of total market demand for retail trading services in Izhevsk for a moment in 2008.

  17. Cations analysis by controlled potential coulometry. Pt. 2. Zirconium and thorium determination

    International Nuclear Information System (INIS)

    Harto Castano, A.; Sanchez Batanero, P.

    1982-01-01

    A controlled-potential coulometry method for determination of zirconium and thorium has been carried out. This method is based on the reduction of potassium ferricyanide in presence of zirconium and thorium ions in acidic media. Stoechiometric coefficients of the solid products have been determined by intensity-controlled coulometry and chemical analysis. Application range and accuracy of the coulometric method has been established and applied to determination of Zr(IV) and Th(IV) in ores [fr

  18. Potential biomarkers of tardive dyskinesia: A multiplex analysis of blood serum

    OpenAIRE

    Boiko, Anastasia S; Kornetova, Elena G; Ivanova, Svetlana A.; Loonen, Antonius

    2017-01-01

    Potential biomarkers of tardive dyskinesia: a multiplex analysis of blood serum A.S. Boiko(1), E.G. Kornetova(2), S.A. Ivanova(1), A.J.M. Loonen(3) (1)Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Laboratory of Molecular Genetics and Biochemistry, Tomsk, Russia (2)Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Department of Endogenous Disorders, Tomsk, Russia (3)Univers...

  19. A critical analysis of energy efficiency improvement potentials in Taiwan's cement industry

    International Nuclear Information System (INIS)

    Huang, Yun-Hsun; Chang, Yi-Lin; Fleiter, Tobias

    2016-01-01

    The cement industry is the second most energy-intensive sector in Taiwan, which underlines the need to understand its potential for energy efficiency improvement. A bottom-up model-based assessment is utilized to conduct a scenario analysis of energy saving opportunities up to the year 2035. The analysis is supported by detailed expert interviews in all cement plants of Taiwan. The simulation results reveal that by 2035, eighteen energy efficient technologies could result in 25% savings for electricity and 9% savings for fuels under the technical diffusion scenario. This potential totally amounts to about 5000 TJ/year, of which 91% can be implemented cost-effectively assuming a discount rate of 10%. Policy makers should support a fast diffusion of these technologies. Additionally, policy makers can tap further saving potentials. First, by decreasing the clinker share, which is currently regulated to a minimum of 95%. Second, by extending the prohibition to build new cement plants by allowing for replacement of existing capacity with new innovative plants in the coming years. Third, by supporting the use of alternative fuels, which is currently still a niche in Taiwan. - Highlights: •We analyze energy efficiency improvement potentials in Taiwan's cement industry. •Eighteen process-specific technologies are analyzed using a bottom-up model. •Our model systematically reflects the diffusion of technologies over time. •We find energy-saving potentials of 25% for electricity and 9% for fuels in 2035. •91% of the energy-saving potentials can be realized cost-effectively.

  20. NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis.

    Science.gov (United States)

    Cui, Jiajia; Liu, Yuetao; Hu, Yinghuan; Tong, Jiayu; Li, Aiping; Qu, Tingli; Qin, Xuemei; Du, Guanhua

    2017-01-05

    Chronic atrophic gastritis (CAG) is one of the most important pre-cancerous states with a high prevalence. Exploring of the underlying mechanism and potential biomarkers is of significant importance for CAG. In the present work, 1 H NMR-based metabonomics with correlative analysis was performed to analyze the metabolic features of CAG. 19 plasma metabolites and 18 urine metabolites were enrolled to construct the circulatory and excretory metabolome of CAG, which was in response to alterations of energy metabolism, inflammation, immune dysfunction, as well as oxidative stress. 7 plasma biomarkers and 7 urine biomarkers were screened to elucidate the pathogenesis of CAG based on the further correlation analysis with biochemical indexes. Finally, 3 plasma biomarkers (arginine, succinate and 3-hydroxybutyrate) and 2 urine biomarkers (α-ketoglutarate and valine) highlighted the potential to indicate risks of CAG in virtue of correlation with pepsin activity and ROC analysis. Here, our results paved a way for elucidating the underlying mechanisms in the development of CAG, and provided new avenues for the diagnosis of CAG and presented potential drug targets for treatment of CAG. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Stability Analysis and Variational Integrator for Real-Time Formation Based on Potential Field

    Directory of Open Access Journals (Sweden)

    Shengqing Yang

    2014-01-01

    Full Text Available This paper investigates a framework of real-time formation of autonomous vehicles by using potential field and variational integrator. Real-time formation requires vehicles to have coordinated motion and efficient computation. Interactions described by potential field can meet the former requirement which results in a nonlinear system. Stability analysis of such nonlinear system is difficult. Our methodology of stability analysis is discussed in error dynamic system. Transformation of coordinates from inertial frame to body frame can help the stability analysis focus on the structure instead of particular coordinates. Then, the Jacobian of reduced system can be calculated. It can be proved that the formation is stable at the equilibrium point of error dynamic system with the effect of damping force. For consideration of calculation, variational integrator is introduced. It is equivalent to solving algebraic equations. Forced Euler-Lagrange equation in discrete expression is used to construct a forced variational integrator for vehicles in potential field and obstacle environment. By applying forced variational integrator on computation of vehicles' motion, real-time formation of vehicles in obstacle environment can be implemented. Algorithm based on forced variational integrator is designed for a leader-follower formation.

  2. Effect of caffeine on vestibular evoked myogenic potential: a systematic review with meta-analysis.

    Science.gov (United States)

    Souza, Maria Eduarda Di Cavalcanti Alves de; Costa, Klinger Vagner Teixeira da; Menezes, Pedro de Lemos

    2017-12-24

    Caffeine can be considered the most consumed drug by adults worldwide, and can be found in several foods, such as chocolate, coffee, tea, soda and others. Overall, caffeine in moderate doses, results in increased physical and intellectual productivity, increases the capacity of concentration and reduces the time of reaction to sensory stimuli. On the other hand, high doses can cause noticeable signs of mental confusion and error induction in intellectual tasks, anxiety, restlessness, muscle tremors, tachycardia, labyrinthine changes, and tinnitus. Considering that the vestibular evoked myogenic potential is a clinical test that evaluates the muscular response of high intensity auditory stimulation, the present systematic review aimed to analyze the effects of caffeine on vestibular evoked myogenic potential. This study consisted of the search of the following databases: MEDLINE, CENTRAL, ScienceDirect, Scopus, Web of Science, LILACS, SciELO and ClinicalTrials.gov. Additionally, the gray literature was also searched. The search strategy included terms related to intervention (caffeine or coffee consumption) and the primary outcome (vestibular evoked myogenic potential). Based on the 253 potentially relevant articles identified through the database search, only two full-text publications were retrieved for further evaluation, which were maintained for qualitative analysis. Analyzing the articles found, caffeine has no effect on vestibular evoked myogenic potential in normal individuals. Copyright © 2017 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  3. Geothermal direct heat use: Market potential/penetration analysis for Federal Region 9

    Science.gov (United States)

    Powell, W. (Editor); Tang, K. (Editor)

    1980-01-01

    A preliminary study was made of the potential for geothermal direct heat use in Arizona, California, Hawaii, and Nevada (Federal Region 9). An analysis was made of each state to: (1) define the resource, based on the latest available data; (2) assess the potential market growth for geothermal energy; and (3) estimate the market penetration, projected to 2020. Findings of the study include the following: (1) Potentially economical hydrothermal resources exist in all four states of the Region: however, the resource data base is largely incomplete, particularly for low to moderate temperature resources. (2) In terms of beneficial heat, the total hydrothermal resource identified so far for the four states is on the order of 43 Quads, including an estimated 34 Quads of high temperature resources which are suitable for direct as well as electrical applications. (3) In California, Hawaii, and Nevada, the industrial market sector has somewhat greater potential for penetration than the residential/commercial sector. In Arizona, however, the situation is reversed, due to the collocation of two major metropolitan areas (Phoenix and Tucson) with potential geothermal resources.

  4. Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.

    Science.gov (United States)

    Deevi, Ravi Kiran; Javadi, Arman; McClements, Jane; Vohhodina, Jekaterina; Savage, Kienan; Loughrey, Maurice Bernard; Evergren, Emma; Campbell, Frederick Charles

    2018-04-01

    Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but its role in CRC phenotype evolution remains unclear. Here, we show that PKCz couples genome segregation to multicellular morphology through control of interphase centrosome anchoring. PKCz regulates interdependent processes that control centrosome positioning. Among these, interaction between the cytoskeletal linker protein ezrin and its binding partner NHERF1 promotes the formation of a localized cue for anchoring interphase centrosomes to the cell cortex. Perturbation of these phenomena induced different outcomes in cells with single or extra centrosomes. Defective anchoring of a single centrosome promoted bipolar spindle misorientation, multi-lumen formation, and aberrant epithelial stratification. Collectively, these disturbances induce cribriform multicellular morphology that is typical of some categories of low-grade CRC. By contrast, defective anchoring of extra centrosomes promoted multipolar spindle formation, chromosomal instability (CIN), disruption of glandular morphology, and cell outgrowth across the extracellular matrix interface characteristic of aggressive, high-grade CRC. Because PKCz enhances apical NHERF1 intensity in 3D epithelial cultures, we used an immunohistochemical (IHC) assay of apical NHERF1 intensity as an indirect readout of PKCz activity in translational studies. We show that apical NHERF1 IHC intensity is inversely associated with multipolar spindle frequency and high-grade morphology in formalin-fixed human CRC samples. To conclude, defective PKCz control of interphase centrosome anchoring may underlie distinct categories of

  5. Phosphorylated Protein Kinase C (Zeta/Lambda) Expression in Colorectal Adenocarcinoma and Its Correlation with Clinicopathologic Characteristics and Prognosis.

    Science.gov (United States)

    Yeo, Min-Kyung; Kim, Ji Yeon; Seong, In-Ock; Kim, Jin-Man; Kim, Kyung-Hee

    2017-01-01

    Background: Protein kinase C zeta/lambda (PKCζ/λ) is a family of protein kinase enzymes that contributes to cell proliferation and regulation, which are important for cancer development. PKCζ/λ has been shown to be an important regulator of tumorigenesis in intestinal cancer. The phosphorylated form of PKCζ/λ, p-PKCζ/λ, is suggested as an active form of PKCζ/λ. However, p-PKCζ/λ expression and its clinicopathologic implication in colorectal adenocarcinoma (CRAC) are unclear. Methods: Seven whole-tissue sections of malignant polyps containing both non-neoplastic and neoplastic mucosa, 11 adenomas with low-grade dysplasia, and 173 CRACs were examined by immunohistochemistry and western blot assay for p-PKCζ/λ protein expression. The association of p-PKCζ/λ expression with clinicopathologic factors including patient survival was studied. Results: In non-neoplastic epithelia, p-PKCζ/λ showed a weak cytoplasmic immunostaining. Adenomas and CRACs demonstrated up-regulated p-PKCζ/λ detection. Cytoplasmic p-PKCζ/λ expression was higher in CRAC than in adenoma. In CRACs, p-PKCζ/λ expression was inversely correlated with pathologic TNM stage (I-II versus III-IV) and poor differentiation. Statistical correlations between low expression of p-PKCζ/λ with shortened overall survival and disease-free survival were seen (p=0.004 and p=0.034, respectively). Conclusions: P-PKCζ/λ overexpression is implicated in tumorigenesis but down-regulation was a poor prognostic factor in CRAC.

  6. Acoustic and temporal analysis of speech: A potential biomarker for schizophrenia.

    LENUS (Irish Health Repository)

    Rapcan, Viliam

    2010-11-01

    Currently, there are no established objective biomarkers for the diagnosis or monitoring of schizophrenia. It has been previously reported that there are notable qualitative differences in the speech of schizophrenics. The objective of this study was to determine whether a quantitative acoustic and temporal analysis of speech may be a potential biomarker for schizophrenia. In this study, 39 schizophrenic patients and 18 controls were digitally recorded reading aloud an emotionally neutral text passage from a children\\'s story. Temporal, energy and vocal pitch features were automatically extracted from the recordings. A classifier based on linear discriminant analysis was employed to differentiate between controls and schizophrenic subjects. Processing the recordings with the algorithm developed demonstrated that it is possible to differentiate schizophrenic patients and controls with a classification accuracy of 79.4% (specificity=83.6%, sensitivity=75.2%) based on speech pause related parameters extracted from recordings carried out in standard office (non-studio) environments. Acoustic and temporal analysis of speech may represent a potential tool for the objective analysis in schizophrenia.

  7. HST-WFC3 Near-Infrared Spectroscopy of Quenched Galaxies at zeta approx 1.5 from the WISP Survey: Stellar Populations Properties

    Science.gov (United States)

    Bedregal, A. G.; Scarlata, C.; Henry, A. L.; Atek, H.; Rafelski, M.; Teplitz, H. I.; Dominguez, A.; Siana, B.; Colbert, J. W.; Malkan, M.; hide

    2013-01-01

    We combine Hubble Space Telescope (HST) G102 and G141 near-IR (NIR) grism spectroscopy with HST/WFC3- UVIS, HST/WFC3-IR, and Spitzer/IRAC [3.6 microns] photometry to assemble a sample of massive (log(Mstar/M solar mass) at approx 11.0) and quenched (specific star formation rate spectroscopy for quenched sources at these redshifts. In contrast to the local universe, zeta approx 1.5 quenched galaxies in the high-mass range have a wide range of stellar population properties. We find that their spectral energy distributions (SEDs) are well fitted with exponentially decreasing star formation histories and short star formation timescales (tau less than or equal to 100 M/yr). Quenched galaxies also show a wide distribution in ages, between 1 and 4 G/yr. In the (u - r)0-versus-mass space quenched galaxies have a large spread in rest-frame color at a given mass. Most quenched galaxies populate the zeta appro. 1.5 red sequence (RS), but an important fraction of them (32%) have substantially bluer colors. Although with a large spread, we find that the quenched galaxies on the RS have older median ages (3.1 G/yr) than the quenched galaxies off the RS (1.5 G/yr). We also show that a rejuvenated SED cannot reproduce the observed stacked spectra of (the bluer) quenched galaxies off the RS. We derive the upper limit on the fraction of massive galaxies on the RS at zeta approx 1.5 to be 2 and the zeta approx 1.5 RS. According to their estimated ages, the time required for quenched galaxies off the RS to join their counterparts on the z approx. 1.5 RS is of the order of approx. 1G/yr.

  8. Wind energy potential of coastal Eritrea: an analysis of sparse wind data

    International Nuclear Information System (INIS)

    Rosen, K.; Buskirk, R. van; Garbesi, K.

    1999-01-01

    This paper describes an analysis of historical surface wind data for the small country of Eritrea, in northeastern Africa. Winds in this region are directed by summer and winter monsoons in addition to diurnal land-sea effects. An analysis of national Eritrean and historical Italian wind records indicated marginal wind resources in the central highlands near the Eritrean capital of Asmera. An analysis of wind speed records recorded at two sites in the southern port city of Aseb indicate mean annual 10-m wind speeds of 9.5 m s -1 at the windier site. Surface wind speed records for the Red Sea suggest that similar potential may be found along the lower 200 km of the Eritrean coastline. Based on these findings, wind-generated electricity in this region should be substantially cheaper than the current supply generated from imported diesel. (author)

  9. Analysis of transactivation potential of rice (Oryza sativa L.) heat shock factors.

    Science.gov (United States)

    Lavania, Dhruv; Dhingra, Anuradha; Grover, Anil

    2018-06-01

    Based on yeast one-hybrid assays, we show that the presence of C-terminal AHA motifs is not a prerequisite for transactivation potential in rice heat shock factors. Transcriptional activation or transactivation (TA) of heat stress responsive genes takes place by binding of heat shock factors (Hsfs) to heat shock elements. Analysis of TA potential of thirteen rice (Oryza sativa L.) Hsfs (OsHsfs) carried out in this study by yeast one-hybrid assay showed that OsHsfsA3 possesses strong TA potential while OsHsfs A1a, A2a, A2b, A4a, A4d, A5, A7b, B1, B2a, B2b, B2c and B4d lack TA potential. From a near complete picture of TA potential of the OsHsf family (comprising of 25 members) emerging from this study and an earlier report from our group (Mittal et al. in FEBS J 278(17):3076-3085, 2011), it is concluded that (1) overall, six OsHsfs, namely A3, A6a, A6b, A8, C1a and C1b possess TA potential; (2) four class A OsHsfs, namely A3, A6a, A6b and A8 have TA potential out of which A6a and A6b contain AHA motifs while A3 and A8 lack AHA motifs; (3) nine class A OsHsfs, namely A1a, A2a, A2b, A2e, A4a, A4d, A5, A7a and A7b containing AHA motif(s) lack TA function in the yeast assay system; (4) all class B OsHsfs lack AHA motifs and TA potential (B4a not analyzed) and (5) though all class C OsHsf members lack AHA motifs, two members C1a and C1b possess TA function, while one member C2a lacks TA potential (C2b not analyzed). Thus, the presence or absence of AHA motif is possibly not the only factor determining TA potential of OsHsfs. Our findings will help to identify the transcriptional activators of rice heat shock response.

  10. Variance of a potential of mean force obtained using the weighted histogram analysis method.

    Science.gov (United States)

    Cukier, Robert I

    2013-11-27

    A potential of mean force (PMF) that provides the free energy of a thermally driven system along some chosen reaction coordinate (RC) is a useful descriptor of systems characterized by complex, high dimensional potential energy surfaces. Umbrella sampling window simulations use potential energy restraints to provide more uniform sampling along a RC so that potential energy barriers that would otherwise make equilibrium sampling computationally difficult can be overcome. Combining the results from the different biased window trajectories can be accomplished using the Weighted Histogram Analysis Method (WHAM). Here, we provide an analysis of the variance of a PMF along the reaction coordinate. We assume that the potential restraints used for each window lead to Gaussian distributions for the window reaction coordinate densities and that the data sampling in each window is from an equilibrium ensemble sampled so that successive points are statistically independent. Also, we assume that neighbor window densities overlap, as required in WHAM, and that further-than-neighbor window density overlap is negligible. Then, an analytic expression for the variance of the PMF along the reaction coordinate at a desired level of spatial resolution can be generated. The variance separates into a sum over all windows with two kinds of contributions: One from the variance of the biased window density normalized by the total biased window density and the other from the variance of the local (for each window's coordinate range) PMF. Based on the desired spatial resolution of the PMF, the former variance can be minimized relative to that from the latter. The method is applied to a model system that has features of a complex energy landscape evocative of a protein with two conformational states separated by a free energy barrier along a collective reaction coordinate. The variance can be constructed from data that is already available from the WHAM PMF construction.

  11. 'Syncing' Up with the Quinn-Rand-Strogatz Constant: Hurwitz-ZetaFunctions in Non-Linear physics

    Energy Technology Data Exchange (ETDEWEB)

    Durgin, Natalie J.; Garcia, Sofia M.; Flournoy, Tamara; Bailey,David H.

    2007-12-01

    This work extends the analytical and computationalinvestigation of the Quinn-Rand-Strogatz (QRS) constants from non-linearphysics. The QRS constants (c1, c2, ..., cN) are found in a Winfreeoscillator mean-field system used to examine the transition of coupledoscillators as they lose synchronization. The constants are part of anasymptotic expansion of a function related to the oscillatorsynchronization. Previous work used high-precision software packages toevaluate c1 to 42 decimal-digits, which made it possible to recognize andprove that c1 was the root of a certain Hurwitz-zeta function. Thisallowed a value of c2 to beconjectured in terms of c1. Therefore thereis interest in determining the exact values of these constants to highprecision in the hope that general relationships can be establishedbetween the constants and the zeta functions. Here, we compute the valuesof the higher order constants (c3, c4) to more than 42-digit precision byextending an algorithm developed by D.H. Bailey, J.M. Borwein and R.E.Crandall. Several methods for speeding up the computation are exploredand an alternate proof that c1 is the root of a Hurwitz-zeta function isattempted.

  12. Analysis of Light-Induced Transmembrane Ion Gradients and Membrane Potential in Photosystem I Proteoliposomes

    International Nuclear Information System (INIS)

    Pennisi, Cristian P.; Greenbaum, Elias; Yoshida, Ken

    2010-01-01

    Photosystem I (PSI) complexes can support a light-driven electrochemical gradient for protons, which is the driving force for energy-conserving reactions across biological membranes. In this work, a computational model that enables a quantitative description of the light-induced proton gradients across the membrane of PSI proteoliposomes is presented. Using a set of electrodiffusion equations, a compartmental model of a vesicle suspended in aqueous medium was studied. The light-mediated proton movement was modeled as a single proton pumping step with backpressure of the electric potential. The model fits determinations of pH obtained from PSI proteoliposomes illuminated in the presence of mediators of cyclic electron transport. The model also allows analysis of the proton gradients in relation to the transmembrane ion fluxes and electric potential. Sensitivity analysis enabled a determination of the parameters that have greater influence on steady-state levels and onset/decay rates of transmembrane pH and electric potential. This model could be used as a tool for optimizing PSI proteoliposomes for photo-electrochemical applications.

  13. Potential evapotranspiration trend analysis for different climatic zones in Khyber Pakhtunkhwa, Pakistan

    International Nuclear Information System (INIS)

    Nazeer, M.

    2012-01-01

    Estimation of potential evapotranspiration (ETo) plays a significant role in the study of water resources management. The study was conducted to investigate the change in potential evapotranspiration value during the past three decade in three diverse climatic zones of Khyber Pakhtunkhwa, Pakistan. Three Districts of Khyber Pakhtunkhwa, Pakistan (Chitral, Peshawar and D. I. Khan) were selected based on their climatic diversity. Thirty years climatic data (1981-2010) obtained from Pakistan Metrological Department, Islamabad and Agriculture Research Institute, Peshawar was used. Potential evapotranspiration was determined for three decades separately, as well as on mean monthly basis. World Meteorological Organization (WMO) technique was used for trend analysis. Results revealed highest ETo in D. I. Khan followed by Peshawar and Chitral. However, in the summer months ETo value was found highest in Chitral as compared to other selected Districts. Trend analysis results showed that decrease in ETo trend was observed in all the selected Districts with the passage of time. It can be concluded that ETo values decreased as compared to past in all the selected Districts without any discrimination of physical geography and location. (author)

  14. Detection of localised corrosion by means of statistic and harmonic analysis of spontaneous potential noise

    International Nuclear Information System (INIS)

    Carassiti, F.; Cigna, R.; Goolamallee, R.; Gusmano, G.

    1989-01-01

    The analysis of the electrochemical noise, i.e. of the spontaneous fluctuations of potential of a freely corroding electrode, probably represent one of the most interesting novelty of the last years in the field of corrosion monitoring. Although this technique is still at an early stage, it could lead to interesting developments, especially for identifying localized forms of corrosion. The experiments which have been reported in the literature generally agree that in absence of active corrosion a slight variation of the potential is observed accompanied by non gaussian fluctuations; in presence of the onset of pitting a series of sharp variation is observed followed by relatively slow exponential recovery. In the domain of frequency the slope of the noise frequency curve is less than that noticed in the absence of active corrosion. In the domain of time generally the standard deviation of noise is proportional to the corrosion rate. Moreover it has been noticed that small variation in the experimental condition could cause modification in the shape of the spontaneous potential fluctuation and introduce some confusion in the analysis of data. Digital filtering of disturbs could allow a better reproducibility to be achieved. (author) 4 refs., 9 figs

  15. Analysis of the Potential of Low-Temperature Heat Pump Energy Sources

    Directory of Open Access Journals (Sweden)

    Pavel Neuberger

    2017-11-01

    Full Text Available The paper deals with an analysis of temperatures of ground masses in the proximities of linear and slinky-type HGHE (horizontal ground heat exchanger. It evaluates and compares the potentials of HGHEs and ambient air. The reason and aim of the verification was to gain knowledge of the temperature course of the monitored low-temperature heat pump energy sources during heating periods and periods of stagnation and to analyse the knowledge in terms of the potential to use those sources for heat pumps. The study was conducted in the years 2012–2015 during three heating periods and three periods of HGHEs stagnation. The results revealed that linear HGHE had the highest temperature potential of the observed low-temperature heat pump energy sources. The average daily temperatures of the ground mass surrounding the linear HGHE were the highest ranging from 7.08 °C to 9.20 °C during the heating periods, and having the lowest temperature variation range of 12.62–15.14 K, the relative frequency of the average daily temperatures of the ground mass being the highest at 22.64% in the temperature range containing the mode of all monitored temperatures in a recorded interval of [4.10, 6.00] °C. Ambient air had lower temperature potential than the monitored HGHEs.

  16. Biofuel developments in Mozambique. Update and analysis of policy, potential and reality

    International Nuclear Information System (INIS)

    Schut, Marc; Slingerland, Maja; Locke, Anna

    2010-01-01

    Climate change, rising oil prices and concerns about future energy supplies have contributed to a growing interest in using biomass for energy purposes. Several studies have highlighted the biophysical potential of biofuel production on the African continent, and analysts see Mozambique as one of the most promising African countries. Favorable growing conditions and the availability of land, water and labor are mentioned as major drivers behind this potential. Moreover, the potential of biofuel production to generate socio-economic benefits is reflected in the government's policy objectives for the development of the sector, such as reducing fuel import dependency and creating rural employment. This article provides an overview of biofuel developments in Mozambique and explores to what extent reality matches the suggested potential in the country. We conclude that biofuel developments mainly take place in areas near good infrastructure, processing and storage facilities, where there is (skilled) labor available, and access to services and goods. Moreover, our analysis shows the need to timely harmonize current trends in biofuel developments with the government's policy objectives as the majority of existing and planned projects are not focusing on remote rural areas, and - in absence of domestic markets - principally target external markets.

  17. HPLC analysis of potentially harmful substances released from dental filing aterials available on the EU market

    Directory of Open Access Journals (Sweden)

    Konrad Małkiewicz

    2014-03-01

    Full Text Available Introduction. Incomplete cross-linking of composite dental materials leads to their susceptibility to degradation in the environment of non-organic and organic solvents, contributing to the release of chemical compounds which are potentially harmful to living organisms. Objective. The aim of the study was an evaluation in in vitro conditions of releasing of potentially toxic substances from six dental composite materials available in EU countries. Materials and methods. The following compounds released from the samples stored in water were analyzed: bisphenol A (BPA, triethylene glycol-dimethacrylate (TEGDMA, urethane dimethacrylate (UDMA and ethylene glycol dimethacrylate (EDGMA. Analysis of the substances was performed with the use of high performance liquid chromatography, after the following incubation periods: 1 hour, 24 hours, 7 days and 30 days. Results. Among the analyzed substances, after 1 hour of incubation, the highest average concentration was found for TEGDMA – 2045 μg cm-3 (in Herculite XRV material, after 24 hours – for UDMA 4.402 μg cm-3 (in Gradia Direct Anterior material and after 7 and 30 days for TEGDMA: 8.112 and 6.458 μg•cm-3 respectively (in Charisma material. Conclusions. The examined composites used for reconstruction of hard tissues of teeth remain chemically unstable after polymerization, and release potentially harmful substances in conditions of the present study. The dynamics of the releasing of potentially harmful substances is correlated with the period of sample storage in water.

  18. PC based controlled potential coulometric titrator for quantitative analysis of nuclear materials

    International Nuclear Information System (INIS)

    Manna, A.; Moorthy, A.D.; Bhogale, R.G.

    2001-01-01

    With increased requirements for process control and accountability of nuclear materials in plutonium reprocessing plants, the PC based controlled potential coulometric titrator was developed which has the capability of automatic quantitative analysis of the samples. The instruments based on electromechanical methods, incorporates an electronic potentiostat, a digital coulometer with wide dynamic range and a PC with a control interface card. The potentiostat is required to control the potential at the working electrode surface as per predetermined controlled voltage with respect to a reference electrode under wide variations in the conductivity and double layer capacitance of the electrochemical cell. The digital coulometer precisely measures the amount of electronic charge taking part in the electrochemical reactions of interest. The software has the facility to carry out three different types of analysis, i.e., primary coulometry, secondary coulometry and coulogram curve tracing. Due to complete analysis of the samples under program control, the human related errors are minimized and a better precision in the results are obtained. It has been possible to obtain an overall precession of better than +/- 0.3% in the determination of plutonium using the instrument. (author)

  19. Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials.

    Science.gov (United States)

    Huart, C; Rombaux, Ph; Hummel, T; Mouraux, A

    2013-09-01

    The clinical usefulness of olfactory event-related brain potentials (OERPs) to assess olfactory function is limited by the relatively low signal-to-noise ratio of the responses identified using conventional time-domain averaging. Recently, it was shown that time-frequency analysis of the obtained EEG signals can markedly improve the signal-to-noise ratio of OERPs in healthy controls, because it enhances both phase-locked and non phase-locked EEG responses. The aim of the present study was to investigate the clinical usefulness of this approach and evaluate its feasibility in a clinical setting. We retrospectively analysed EEG recordings obtained from 45 patients (15 anosmic, 15 hyposmic and 15 normos- mic). The responses to olfactory stimulation were analysed using conventional time-domain analysis and joint time-frequency analysis. The ability of the two methods to discriminate between anosmic, hyposmic and normosmic patients was assessed using a Receiver Operating Characteristic analysis. The discrimination performance of OERPs identified using conventional time-domain averaging was poor. In contrast, the discrimination performance of the EEG response identified in the time-frequency domain was relatively high. Furthermore, we found a significant correlation between the magnitude of this response and the psychophysical olfactory score. Time-frequency analysis of the EEG responses to olfactory stimulation could be used as an effective and reliable diagnostic tool for the objective clinical evaluation of olfactory function in patients.

  20. Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview

    Directory of Open Access Journals (Sweden)

    Jorge Pereira

    2015-01-01

    Full Text Available Currently, a small number of diseases, particularly cardiovascular (CVDs, oncologic (ODs, neurodegenerative (NDDs, chronic respiratory diseases, as well as diabetes, form a severe burden to most of the countries worldwide. Hence, there is an urgent need for development of efficient diagnostic tools, particularly those enabling reliable detection of diseases, at their early stages, preferably using non-invasive approaches. Breath analysis is a non-invasive approach relying only on the characterisation of volatile composition of the exhaled breath (EB that in turn reflects the volatile composition of the bloodstream and airways and therefore the status and condition of the whole organism metabolism. Advanced sampling procedures (solid-phase and needle traps microextraction coupled with modern analytical technologies (proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry, ion mobility spectrometry, e-noses, etc. allow the characterisation of EB composition to an unprecedented level. However, a key challenge in EB analysis is the proper statistical analysis and interpretation of the large and heterogeneous datasets obtained from EB research. There is no standard statistical framework/protocol yet available in literature that can be used for EB data analysis towards discovery of biomarkers for use in a typical clinical setup. Nevertheless, EB analysis has immense potential towards development of biomarkers for the early disease diagnosis of diseases.

  1. Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.

    Science.gov (United States)

    Pereira, Jorge; Porto-Figueira, Priscilla; Cavaco, Carina; Taunk, Khushman; Rapole, Srikanth; Dhakne, Rahul; Nagarajaram, Hampapathalu; Câmara, José S

    2015-01-09

    Currently, a small number of diseases, particularly cardiovascular (CVDs), oncologic (ODs), neurodegenerative (NDDs), chronic respiratory diseases, as well as diabetes, form a severe burden to most of the countries worldwide. Hence, there is an urgent need for development of efficient diagnostic tools, particularly those enabling reliable detection of diseases, at their early stages, preferably using non-invasive approaches. Breath analysis is a non-invasive approach relying only on the characterisation of volatile composition of the exhaled breath (EB) that in turn reflects the volatile composition of the bloodstream and airways and therefore the status and condition of the whole organism metabolism. Advanced sampling procedures (solid-phase and needle traps microextraction) coupled with modern analytical technologies (proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry, ion mobility spectrometry, e-noses, etc.) allow the characterisation of EB composition to an unprecedented level. However, a key challenge in EB analysis is the proper statistical analysis and interpretation of the large and heterogeneous datasets obtained from EB research. There is no standard statistical framework/protocol yet available in literature that can be used for EB data analysis towards discovery of biomarkers for use in a typical clinical setup. Nevertheless, EB analysis has immense potential towards development of biomarkers for the early disease diagnosis of diseases.

  2. Phytochemical analysis of Andrographis paniculata and Orthosiphon stamineus leaf extracts for their antibacterial and antioxidant potential.

    Science.gov (United States)

    Malahubban, M; Alimon, A R; Sazili, A Q; Fakurazi, S; Zakry, F A

    2013-09-01

    Leaves of Andrographis paniculata and Orthosiphon stamineus were extracted with water, ethanol, methanol and chloroform to assess their potential as antibacterial and antioxidant agents. High performance liquid chromatography analysis showed that the methanolic extracts of A. paniculata and O. stamineus leaves gave the highest amounts of andrographolide and rosmarinic acid, respectively. These leaf extracts exhibited antimicrobial and antioxidant activities and, at the highest concentration tested (200 mg/mL), showed greater inhibitory effects against the Gram positive bacteria Bacillus cereus and Staphylococcus aureus than 10% acetic acid. Andrographis paniculata and O. stamineus methanolic and ethanolic leaf extracts also showed the strongest antioxidant activity as compared with the other extracts tested. The bioactive compounds present in these leaf extracts have the potential to be developed into natural antibacterial and antioxidant agents that may have applications in animal and human health.

  3. THE COMPARATIVE ANALYSIS OF TWO DIFFERENT STATISTICAL DISTRIBUTIONS USED TO ESTIMATE THE WIND ENERGY POTENTIAL

    Directory of Open Access Journals (Sweden)

    Mehmet KURBAN

    2007-01-01

    Full Text Available In this paper, the wind energy potential of the region is analyzed with Weibull and Reyleigh statistical distribution functions by using the wind speed data measured per 15 seconds in July, August, September, and October of 2005 at 10 m height of 30-m observation pole in the wind observation station constructed in the coverage of the scientific research project titled "The Construction of Hybrid (Wind-Solar Power Plant Model by Determining the Wind and Solar Potential in the Iki Eylul Campus of A.U." supported by Anadolu University. The Maximum likelihood method is used for finding the parameters of these distributions. The conclusion of the analysis for the months taken represents that the Weibull distribution models the wind speeds better than the Rayleigh distribution. Furthermore, the error rate in the monthly values of power density computed by using the Weibull distribution is smaller than the values by Rayleigh distribution.

  4. Analysis of Solar Potential of Roofs Based on Digital Terrain Model

    Science.gov (United States)

    Gorički, M.; Poslončec-Petrić, V.; Frangeš, S.; Bačić, Ž.

    2017-09-01

    One of the basic goals of the smart city concept is to create a high-quality environment that is long sustainable and economically justifiable. The priority and concrete goal today is to promote and provide sustainable sources of energy (SSE). Croatia is rich with sun energy and as one of the sunniest European countries, it has a huge insufficiently used solar potential at its disposal. The paper describes the procedure of analysing the solar potential of a pilot area Sveti Križ Začretje by means of digital surface model (DSM) and based on the data available in the Meteorological and Hydrological Service of the Republic of Croatia. Although a more detailed analysis would require some additional factors, it is clear that the installation of 19,6m2 of solar panels in each household could cover annual requirements of the household in the analysed area, the locality Sveti Križ Začretje.

  5. The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer.

    Science.gov (United States)

    Ross, Kirsty; Pailler, Emma; Faugeroux, Vincent; Taylor, Melissa; Oulhen, Marianne; Auger, Nathalie; Planchard, David; Soria, Jean-Charles; Lindsay, Colin R; Besse, Benjamin; Vielh, Philippe; Farace, Françoise

    2015-01-01

    In non-small-cell lung cancer (NSCLC), genotyping tumor biopsies for targetable somatic alterations has become routine practice. However, serial biopsies have limitations: they may be technically difficult or impossible and could incur serious risks to patients. Circulating tumor cells (CTCs) offer an alternative source for tumor analysis that is easily accessible and presents the potential to identify predictive biomarkers to tailor therapies on a personalized basis. Examined here is our current knowledge of CTC detection and characterization in NSCLC and their potential role in EGFR-mutant, ALK-rearranged and ROS1-rearranged patients. This is followed by discussion of the ongoing issues such as the question of CTC partnership as diagnostic tools in NSCLC.

  6. The Recording and Quantification of Event-Related Potentials: II. Signal Processing and Analysis

    Directory of Open Access Journals (Sweden)

    Paniz Tavakoli

    2015-06-01

    Full Text Available Event-related potentials are an informative method for measuring the extent of information processing in the brain. The voltage deflections in an ERP waveform reflect the processing of sensory information as well as higher-level processing that involves selective attention, memory, semantic comprehension, and other types of cognitive activity. ERPs provide a non-invasive method of studying, with exceptional temporal resolution, cognitive processes in the human brain. ERPs are extracted from scalp-recorded electroencephalography by a series of signal processing steps. The present tutorial will highlight several of the analysis techniques required to obtain event-related potentials. Some methodological issues that may be encountered will also be discussed.

  7. Mapping the geogenic radon potential: methodology and spatial analysis for central Hungary

    International Nuclear Information System (INIS)

    Szabó, Katalin Zsuzsanna; Jordan, Gyozo; Horváth, Ákos; Szabó, Csaba

    2014-01-01

    A detailed geogenic radon potential (GRP) mapping based on field soil gas radon and soil gas permeability measurements was carried out in this study. A conventional continuous variable approach was used in this study for GRP determination and to test its applicability to the selected area of Hungary. Spatial pattern of soil gas radon concentration, soil permeability and GRP and the relationship between geological formations and these parameters were studied by performing detailed spatial analysis. Exploratory data analysis revealed that higher soil gas radon activity concentration and GRP characterizes the mountains and hills than the plains. The highest values were found in the proluvial–deluvial sediments, rock debris on the downhill slopes eroded from hills. Among the Quaternary sediments, which characterize the study area, the fluvial sediment has the highest values, which are also located in the hilly areas. The lowest values were found in the plain areas covered by drift sand, fluvioeolic sand, fluvial sand and loess. As a conclusion, radon is related to the sediment cycle in the study area. A geogenic radon risk map was created, which assists human health risk assessment and risk reduction since it indicates the potential of the source of indoor radon. The map shows that low and medium geogenic radon potential characterizes the study area in central Hungary. High risk occurs only locally. The results reveal that Quaternary sediments are inhomogeneous from a radon point of view, fluvial sediment has medium GRP, whereas the other rock formations such as drift sand, fluioeolic sand, fluvial sand and loess, found in the study area, have low GRP. - Highlights: • First geogenic radon potential map in Hungary. • Low and medium GRP characterizes the study area (Middle Hungary). • Mainly quaternary sediments characterizes the study area. • Radon is related to the erosion and deposition of the sediment cycle

  8. Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis.

    Science.gov (United States)

    Granovsky, Yelena; Matre, Dagfinn; Sokolik, Alexander; Lorenz, Jürgen; Casey, Kenneth L

    2005-06-01

    The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP) stimulator to excite selectively heat receptors with C fibers or Adelta-innervated AMH type 2 receptors in humans. On the dorsal hand, 51 degrees C stimulation produced painful pinprick sensations and 41 degrees C stimuli evoked warmth. On the glabrous thenar, 41 degrees C stimulation produced mild warmth and 51 degrees C evoked strong but painless heat sensations. We used CHEP responses to estimate the conduction velocities (CV) of peripheral fibers mediating these sensations. On hairy skin, 41 degrees C stimuli evoked an ultra-late potential (mean, SD; N wave latency: 455 (118) ms) mediated by C fibers (CV by regression analysis: 1.28 m/s, N=15) whereas 51 degrees C stimuli evoked a late potential (N latency: 267 (33) ms) mediated by Adelta afferents (CV by within-subject analysis: 12.9 m/s, N=6). In contrast, thenar responses to 41 and 51 degrees C were mediated by C fibers (average N wave latencies 485 (100) and 433 (73) ms, respectively; CVs 0.95-1.35 m/s by regression analysis, N=15; average CV=1.7 (0.41) m/s calculated from distal glabrous and proximal hairy skin stimulation, N=6). The exploratory range of the human and monkey palm is enhanced by the abundance of low threshold, C-innervated heat receptors and the paucity of low threshold AMH type 2 heat nociceptors.

  9. Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes

    DEFF Research Database (Denmark)

    Møller, Peter; Jacobsen, Nicklas Raun

    2017-01-01

    Carbon nanotube (CNT) is a nanomaterial that has received interest because of its high-tensile strength and low weight. Although CNTs differ substantially in physico-chemical properties, they share high aspect ratio which resembles that of asbestos and other fibers causing lung cancer...... and insufficient mechanistic evidence. Damage to DNA is considered to be a key mechanistic step in the development of fiber-induced cancer. Thus, the genotoxic potential can be a cornerstone in the evaluation of hazards of CNTs. The present study used a weight of evidence (WoE) analysis to evaluate...

  10. Viscous Potential Flow Analysis of Electroaerodynamic Instability of a Liquid Sheet Sprayed with an Air Stream

    Directory of Open Access Journals (Sweden)

    Mukesh Kumar Awasthi

    2013-01-01

    Full Text Available The instability of a thin sheet of viscous and dielectric liquid moving in the same direction as an air stream in the presence of a uniform horizontal electric field has been carried out using viscous potential flow theory. It is observed that aerodynamic-enhanced instability occurs if the Weber number is much less than a critical value related to the ratio of the air and liquid stream velocities, viscosity ratio of two fluids, the electric field, and the dielectric constant values. Liquid viscosity has stabilizing effect in the stability analysis, while air viscosity has destabilizing effect.

  11. Mathematical analysis of the dimensional scaling technique for the Schroedinger equation with power-law potentials

    International Nuclear Information System (INIS)

    Ding Zhonghai; Chen, Goong; Lin, Chang-Shou

    2010-01-01

    The dimensional scaling (D-scaling) technique is an innovative asymptotic expansion approach to study the multiparticle systems in molecular quantum mechanics. It enables the calculation of ground and excited state energies of quantum systems without having to solve the Schroedinger equation. In this paper, we present a mathematical analysis of the D-scaling technique for the Schroedinger equation with power-law potentials. By casting the D-scaling technique in an appropriate variational setting and studying the corresponding minimization problem, the D-scaling technique is justified rigorously. A new asymptotic dimensional expansion scheme is introduced to compute asymptotic expansions for ground state energies.

  12. The Analysis of the Potential Environmental Benefits by Investigating the Hedonistic Price

    Directory of Open Access Journals (Sweden)

    Giani Gradinaru

    2008-07-01

    Full Text Available Consumers get some usefulness from the attributes of heterogeneous products and they adjust their acquisitions as a response to the existing differences. Producers or vendors confront with varying prices depending on the scale of attributes provided. A plan for balancing the prices is developed as a consequence of the market interaction between the consumers and suppliers (by analogy it happens in the case of the interaction between employees and employers on the labour market. Taking into consideration the late concepts regarding hedonistic price, the article presents a way of analysis of potential benefits that environment may offer to human communities by hedonistic price investigation, using regression as instrument.

  13. Multi-criteria analysis of potential recovery facilities in a reverse supply chain

    Science.gov (United States)

    Nukala, Satish; Gupta, Surendra M.

    2005-11-01

    Analytic Hierarchy Process (AHP) has been employed by researchers for solving multi-criteria analysis problems. However, AHP is often criticized for its unbalanced scale of judgments and failure to precisely handle the inherent uncertainty and vagueness in carrying out the pair-wise comparisons. With an objective to address these drawbacks, in this paper, we employ a fuzzy approach in selecting potential recovery facilities in the strategic planning of a reverse supply chain network that addresses the decision maker's level of confidence in the fuzzy assessments and his/her attitude towards risk. A numerical example is considered to illustrate the methodology.

  14. Data analysis of solar potential in northern Bulgaria obtained by measurements with tall meteorological masts

    International Nuclear Information System (INIS)

    Terziev, A.; Genovski, I.; Petrov, P.; Valchev, V.

    2010-01-01

    Energy from the sun as a renewable energy source could be used for producing not only heat energy but also electricity. The maximum utilization of this type energy requires very good knowledge of the solar radiation for an exact geographical location. Determination of the solar intensity is carried out with special devices called pyranometers. This work considers solar potential data analysis based on data collected from meteorological masts installed in Northern Bulgaria. Comparison between the data from on-site measurements and some long-term data sources well known in literature is also considered. The possibility of studying the interpolation between the points where measurements are carried out in order to obtain solar radiation intensity Filed for the area limited by the points of measurement is also reviewed. Based on correlation analysis results the estimated energy production within the studied area has been calculated. (authors)

  15. Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis

    Science.gov (United States)

    Singer, M. S.; Oliveira, L.; Vriend, G.; Shepherd, G. M.

    1995-01-01

    A family of G-protein-coupled receptors is believed to mediate the recognition of odor molecules. In order to identify potential ligand-binding residues, we have applied correlated mutation analysis to receptor sequences from the rat. This method identifies pairs of sequence positions where residues remain conserved or mutate in tandem, thereby suggesting structural or functional importance. The analysis supported molecular modeling studies in suggesting several residues in positions that were consistent with ligand-binding function. Two of these positions, dominated by histidine residues, may play important roles in ligand binding and could confer broad specificity to mammalian odor receptors. The presence of positive (overdominant) selection at some of the identified positions provides additional evidence for roles in ligand binding. Higher-order groups of correlated residues were also observed. Each group may interact with an individual ligand determinant, and combinations of these groups may provide a multi-dimensional mechanism for receptor diversity.

  16. Analysis of Potential Benefits and Costs of Adopting a Commercial Building Energy Standard in South Dakota

    Energy Technology Data Exchange (ETDEWEB)

    Belzer, David B.; Cort, Katherine A.; Winiarski, David W.; Richman, Eric E.

    2005-03-04

    The state of South Dakota is considering adopting a commercial building energy standard. This report evaluates the potential costs and benefits to South Dakota residents from requiring compliance with the most recent edition of the ANSI/ASHRAE/IESNA 90.1-2001 Energy Standard for Buildings except Low-Rise Residential Buildings. These standards were developed in an effort to set minimum requirements for the energy efficient design and construction of new commercial buildings. The quantitative benefits and costs of adopting a commercial building energy code are modeled by comparing the characteristics of assumed current building practices with the most recent edition of the ASHRAE Standard, 90.1-2001. Both qualitative and quantitative benefits and costs are assessed in this analysis. Energy and economic impacts are estimated using results from a detailed building simulation tool (Building Loads Analysis and System Thermodynamics [BLAST] model) combined with a Life-Cycle Cost (LCC) approach to assess corresponding economic costs and benefits.

  17. Crossing the Barriers: An Analysis of Land Access Barriers to Geothermal Development and Potential Improvement Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Young, Katherine R [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-04

    Developers have identified many non-technical barriers to geothermal power development, including access to land. Activities required for accessing land, such as environmental review and private and public leasing can take a considerable amount of time and can delay or prevent project development. This paper discusses the impacts to available geothermal resources and deployment caused by land access challenges, including tribal and cultural resources, environmentally sensitive areas, biological resources, land ownership, federal and state lease queues, and proximity to military installations. In this analysis, we identified challenges that have the potential to prevent development of identified and undiscovered hydrothermal geothermal resources. We found that an estimated 400 MW of identified geothermal resource potential and 4,000 MW of undiscovered geothermal resource potential were either unallowed for development or contained one or more significant barriers that could prevent development at the site. Potential improvement scenarios that could be employed to overcome these barriers include (1) providing continuous funding to the U.S. Forest Service (USFS) for processing geothermal leases and permit applications and (2) the creation of advanced environmental mitigation measures. The model results forecast that continuous funding to the USFS could result in deployment of an additional 80 MW of geothermal capacity by 2030 and 124 MW of geothermal capacity by 2050 when compared to the business-as-usual scenario. The creation of advanced environmental mitigation measures coupled with continuous funding to the USFS could result in deployment of an additional 97 MW of geothermal capacity by 2030 and 152 MW of geothermal capacity by 2050 when compared to the business-as-usual scenario. The small impact on potential deployment in these improvement scenarios suggests that these 4,400 MW have other barriers to development in addition to land access. In other words, simply

  18. An economic analysis of the electricity generation potential from biogas resources in the state of Indiana

    Science.gov (United States)

    Giraldo, Juan S.

    Anaerobic digestion is a process that is a common part of organic waste management systems and is used in concentrated animal feeding operations (CAFOs), wastewater treatment plants (WWTPs), and municipal solid waste (MSW) landfills. The process produces biogas, which contains methane, and it can be burned to generate electricity. Previous reports have indicated that based on the availability of feedstocks there is a large potential for biogas production and use for electricity generation in the state of Indiana. However, these reports varied in their consideration of important factors that affect the technical and economic feasibility of being able to develop the resources available. The goal of this thesis is to make a more targeted assessment of the electricity generation potential from biogas resources at CAFOs, WWTPs, and MSW landfills in Indiana. A capital budgeting model is used to estimate the net present value (NPV) of biogas electricity projects at facilities that are identified as technically suitable. A statewide estimate of the potential generation capacity is made by estimating the number of facilities that could profitably undertake a biogas electricity project. In addition this thesis explored the impact that different incentive policies would have on the economic viability of these projects. The results indicated that the electricity generation potential is much smaller when technical and economic factors are taken into account in addition to feedstock availability. In particular it was found that projects at hog farms are unlikely to be economically feasible in the present even when financial incentives are considered. In total, 47.94 MW of potential generating capacity is estimated from biogas production at CAFOs, WWTPs, and MSW landfills. Though results indicated that 37.10 MW of capacity are economically feasible under current operating conditions, sensitivity analysis reveals that these projects are very sensitive to capital cost assumptions

  19. Detecting potential adverse reactions of sulpiride in schizophrenic patients by prescription sequence symmetry analysis.

    Directory of Open Access Journals (Sweden)

    Edward Chia-Cheng Lai

    Full Text Available PURPOSE: Previous studies have demonstrated sulpiride to be significantly more effective than haloperidol, risperidone and olanzapine in schizophrenic treatment; however, only limited information is available on the potential risks associated with sulpiride treatment. This study attempts to provide information on the potential risks of sulpiride treatment of schizophrenia, especially with regard to unexpected adverse effects. MATERIALS AND METHODS: Patients with schizophrenia aged 18 and older, newly prescribed with a single antipsychotic medication from the National Health Insurance Research Database of Taiwan in the period from 2003 to 2010 were included. A within-subject comparison method, prescription sequence symmetry analysis (PSSA was employed to efficiently identify potential causal relationships while controlling for potential selection bias. RESULTS: A total of 5,750 patients, with a mean age of 39, approximately half of whom were male, constituted the study cohort. The PSSA found that sulpiride was associated with EPS (adjusted SR, 1.73; 95% CI, 1.46-2.06 and hyperprolactinemia (12.04; 1.59-91.2. In comparison, EPS caused by haloperidol has a magnitude of 1.99 when analyzed with PSSA, and hyperprolactinemia caused by amisulpride has a magnitude of 8.05, respectively. Another finding was the unexpected increase in the use of stomatological corticosteroids, emollient laxatives, dermatological preparations of corticosteroids, quinolone antibacterials, and topical products for joint and muscular pain, after initiation of sulpiride treatment. CONCLUSIONS: We found sulpiride to be associated with an increased risk of EPS and hyperprolactinemia, and the potential risk could be as high as that induced by haloperidol and amisulpride, respectively. Additionally, our study provides grounds for future investigations into the associations between sulpiride and the increased use of additional drugs for managing adverse effects, including

  20. Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis.

    Science.gov (United States)

    Meng, Rongqin; Wang, Yang; He, Liang; He, Yuanqing; Du, Zedong

    2018-04-01

    Numerous studies have assessed the diagnostic value of serum p53 (s-p53) antibody in patients with colorectal cancer (CRC); however, results remain controversial. The present study aimed to comprehensively and quantitatively summarize the potential diagnostic value of s-p53 antibody in CRC. The present study utilized databases, including PubMed and EmBase, systematically regarding s-p53 antibody diagnosis in CRC, accessed on and prior to 31 July 2016. The quality of all the included studies was assessed using quality assessment of studies of diagnostic accuracy (QUADAS). The result of pooled sensitivity, pooled specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were analyzed and compared with overall accuracy measures using diagnostic odds ratios (DORs) and area under the curve (AUC) analysis. Publication bias and heterogeneity were also assessed. A total of 11 trials that enrolled a combined 3,392 participants were included in the meta-analysis. Approximately 72.73% (8/11) of the included studies were of high quality (QUADAS score >7), and all were retrospective case-control studies. The pooled sensitivity was 0.19 [95% confidence interval (CI), 0.18-0.21] and pooled specificity was 0.93 (95% CI, 0.92-0.94). Results also demonstrated a PLR of 4.56 (95% CI, 3.27-6.34), NLR of 0.78 (95% CI, 0.71-0.85) and DOR of 6.70 (95% CI, 4.59-9.76). The symmetrical summary receiver operating characteristic curve was 0.73. Furthermore, no evidence of publication bias or heterogeneity was observed in the meta-analysis. Meta-analysis data indicated that s-p53 antibody possesses potential diagnostic value for CRC. However, discrimination power was somewhat limited due to the low sensitivity.

  1. Attenuated total reflectance-FT-IR spectroscopy for gunshot residue analysis: potential for ammunition determination.

    Science.gov (United States)

    Bueno, Justin; Sikirzhytski, Vitali; Lednev, Igor K

    2013-08-06

    The ability to link a suspect to a particular shooting incident is a principal task for many forensic investigators. Here, we attempt to achieve this goal by analysis of gunshot residue (GSR) through the use of attenuated total reflectance (ATR) Fourier transform infrared spectroscopy (FT-IR) combined with statistical analysis. The firearm discharge process is analogous to a complex chemical process. Therefore, the products of this process (GSR) will vary based upon numerous factors, including the specific combination of the firearm and ammunition which was discharged. Differentiation of FT-IR data, collected from GSR particles originating from three different firearm-ammunition combinations (0.38 in., 0.40 in., and 9 mm calibers), was achieved using projection to latent structures discriminant analysis (PLS-DA). The technique was cross (leave-one-out), both internally and externally, validated. External validation was achieved via assignment (caliber identification) of unknown FT-IR spectra from unknown GSR particles. The results demonstrate great potential for ATR-FT-IR spectroscopic analysis of GSR for forensic purposes.

  2. Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Biomarkers of Kidney Cancer.

    Science.gov (United States)

    Song, Yimeng; Zhong, Lijun; Zhou, Juntuo; Lu, Min; Xing, Tianying; Ma, Lulin; Shen, Jing

    2017-12-01

    Renal cell carcinoma (RCC) is a malignant and metastatic cancer with 95% mortality, and clear cell RCC (ccRCC) is the most observed among the five major subtypes of RCC. Specific biomarkers that can distinguish cancer tissues from adjacent normal tissues should be developed to diagnose this disease in early stages and conduct a reliable prognostic evaluation. Data-independent acquisition (DIA) strategy has been widely employed in proteomic analysis because of various advantages, including enhanced protein coverage and reliable data acquisition. In this study, a DIA workflow is constructed on a quadrupole-Orbitrap LC-MS platform to reveal dysregulated proteins between ccRCC and adjacent normal tissues. More than 4000 proteins are identified, 436 of these proteins are dysregulated in ccRCC tissues. Bioinformatic analysis reveals that multiple pathways and Gene Ontology items are strongly associated with ccRCC. The expression levels of L-lactate dehydrogenase A chain, annexin A4, nicotinamide N-methyltransferase, and perilipin-2 examined through RT-qPCR, Western blot, and immunohistochemistry confirm the validity of the proteomic analysis results. The proposed DIA workflow yields optimum time efficiency and data reliability and provides a good choice for proteomic analysis in biological and clinical studies, and these dysregulated proteins might be potential biomarkers for ccRCC diagnosis. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Do's and don'ts in Fourier analysis of steady-state potentials.

    Science.gov (United States)

    Bach, M; Meigen, T

    1999-01-01

    Fourier analysis is a powerful tool in signal analysis that can be very fruitfully applied to steady-state evoked potentials (flicker ERG, pattern ERG, VEP, etc.). However, there are some inherent assumptions in the underlying discrete Fourier transform (DFT) that are not necessarily fulfilled in typical electrophysiological recording and analysis conditions. Furthermore, engineering software-packages may be ill-suited and/or may not fully exploit the information of steady-state recordings. Specifically: * In the case of steady-state stimulation we know more about the stimulus than in standard textbook situations (exact frequency, phase stability), so 'windowing' and calculation of the 'periodogram' are not necessary. * It is mandatory to choose an integer relationship between sampling rate and frame rate when employing a raster-based CRT stimulator. * The analysis interval must comprise an exact integer number (e.g., 10) of stimulus periods. * The choice of the number of stimulus periods per analysis interval needs a wise compromise: A high number increases the frequency resolution, but makes artifact removal difficult; a low number 'spills' noise into the response frequency. * There is no need to feel tied to a power-of-two number of data points as required by standard FFT, 'resampling' is an easy and efficient alternative. * Proper estimates of noise-corrected Fourier magnitude and statistical significance can be calculated that take into account the non-linear superposition of signal and noise. These aspects are developed in an intuitive approach with examples using both simulations and recordings. Proper use of Fourier analysis of our electrophysiological records will reduce recording time and/or increase the reliability of physiologic or pathologic interpretations.

  4. Runoff Potentiality of a Watershed through SCS and Functional Data Analysis Technique

    Science.gov (United States)

    Adham, M. I.; Shirazi, S. M.; Othman, F.; Rahman, S.; Yusop, Z.; Ismail, Z.

    2014-01-01

    Runoff potentiality of a watershed was assessed based on identifying curve number (CN), soil conservation service (SCS), and functional data analysis (FDA) techniques. Daily discrete rainfall data were collected from weather stations in the study area and analyzed through lowess method for smoothing curve. As runoff data represents a periodic pattern in each watershed, Fourier series was introduced to fit the smooth curve of eight watersheds. Seven terms of Fourier series were introduced for the watersheds 5 and 8, while 8 terms of Fourier series were used for the rest of the watersheds for the best fit of data. Bootstrapping smooth curve analysis reveals that watersheds 1, 2, 3, 6, 7, and 8 are with monthly mean runoffs of 29, 24, 22, 23, 26, and 27 mm, respectively, and these watersheds would likely contribute to surface runoff in the study area. The purpose of this study was to transform runoff data into a smooth curve for representing the surface runoff pattern and mean runoff of each watershed through statistical method. This study provides information of runoff potentiality of each watershed and also provides input data for hydrological modeling. PMID:25152911

  5. Analysis of the functional gene structure and metabolic potential of microbial community in high arsenic groundwater.

    Science.gov (United States)

    Li, Ping; Jiang, Zhou; Wang, Yanhong; Deng, Ye; Van Nostrand, Joy D; Yuan, Tong; Liu, Han; Wei, Dazhun; Zhou, Jizhong

    2017-10-15

    Microbial functional potential in high arsenic (As) groundwater ecosystems remains largely unknown. In this study, the microbial community functional composition of nineteen groundwater samples was investigated using a functional gene array (GeoChip 5.0). Samples were divided into low and high As groups based on the clustering analysis of geochemical parameters and microbial functional structures. The results showed that As related genes (arsC, arrA), sulfate related genes (dsrA and dsrB), nitrogen cycling related genes (ureC, amoA, and hzo) and methanogen genes (mcrA, hdrB) in groundwater samples were correlated with As, SO 4 2- , NH 4 + or CH 4 concentrations, respectively. Canonical correspondence analysis (CCA) results indicated that some geochemical parameters including As, total organic content, SO 4 2- , NH 4 + , oxidation-reduction potential (ORP) and pH were important factors shaping the functional microbial community structures. Alkaline and reducing conditions with relatively low SO 4 2- , ORP, and high NH 4 + , as well as SO 4 2- and Fe reduction and ammonification involved in microbially-mediated geochemical processes could be associated with As enrichment in groundwater. This study provides an overall picture of functional microbial communities in high As groundwater aquifers, and also provides insights into the critical role of microorganisms in As biogeochemical cycling. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Runoff Potentiality of a Watershed through SCS and Functional Data Analysis Technique

    Directory of Open Access Journals (Sweden)

    M. I. Adham

    2014-01-01

    Full Text Available Runoff potentiality of a watershed was assessed based on identifying curve number (CN, soil conservation service (SCS, and functional data analysis (FDA techniques. Daily discrete rainfall data were collected from weather stations in the study area and analyzed through lowess method for smoothing curve. As runoff data represents a periodic pattern in each watershed, Fourier series was introduced to fit the smooth curve of eight watersheds. Seven terms of Fourier series were introduced for the watersheds 5 and 8, while 8 terms of Fourier series were used for the rest of the watersheds for the best fit of data. Bootstrapping smooth curve analysis reveals that watersheds 1, 2, 3, 6, 7, and 8 are with monthly mean runoffs of 29, 24, 22, 23, 26, and 27 mm, respectively, and these watersheds would likely contribute to surface runoff in the study area. The purpose of this study was to transform runoff data into a smooth curve for representing the surface runoff pattern and mean runoff of each watershed through statistical method. This study provides information of runoff potentiality of each watershed and also provides input data for hydrological modeling.

  7. Determining Balıkesir’s Energy Potential Using a Regression Analysis Computer Program

    Directory of Open Access Journals (Sweden)

    Bedri Yüksel

    2014-01-01

    Full Text Available Solar power and wind energy are used concurrently during specific periods, while at other times only the more efficient is used, and hybrid systems make this possible. When establishing a hybrid system, the extent to which these two energy sources support each other needs to be taken into account. This paper is a study of the effects of wind speed, insolation levels, and the meteorological parameters of temperature and humidity on the energy potential in Balıkesir, in the Marmara region of Turkey. The relationship between the parameters was studied using a multiple linear regression method. Using a designed-for-purpose computer program, two different regression equations were derived, with wind speed being the dependent variable in the first and insolation levels in the second. The regression equations yielded accurate results. The computer program allowed for the rapid calculation of different acceptance rates. The results of the statistical analysis proved the reliability of the equations. An estimate of identified meteorological parameters and unknown parameters could be produced with a specified precision by using the regression analysis method. The regression equations also worked for the evaluation of energy potential.

  8. SHADOW EFFECT ON PHOTOVOLTAIC POTENTIALITY ANALYSIS USING 3D CITY MODELS

    Directory of Open Access Journals (Sweden)

    N. Alam

    2012-07-01

    Full Text Available Due to global warming, green-house effect and various other drawbacks of existing energy sources, renewable energy like Photovoltaic system is being popular for energy production. The result of photovoltaic potentiality analysis depends on data quality and parameters. Shadow rapidly decreases performance of the Photovoltaic system and it always changes due to the movement of the sun. Solar radiation incident on earth's atmosphere is relatively constant but the radiation at earth's surface varies due to absorption, scattering, reflection, change in spectral content, diffuse component, water vapor, clouds and pollution etc. In this research, it is being investigated that how efficiently real-time shadow can be detected for both direct and diffuse radiation considering reflection and other factors in contrast with the existing shadow detection methods using latest technologies and what is the minimum quality of data required for this purpose. Of course, geometric details of the building geometry and surroundings directly affect the calculation of shadows. In principle, 3D city models or point clouds, which contain roof structure, vegetation, thematically differentiated surface and texture, are suitable to simulate exact real-time shadow. This research would develop an automated procedure to measure exact shadow effect from the 3D city models and a long-term simulation model to determine the produced energy from the photovoltaic system. In this paper, a developed method for detecting shadow for direct radiation has been discussed with its result using a 3D city model to perform a solar energy potentiality analysis.

  9. Quantitative Tissue Proteomics Analysis Reveals Versican as Potential Biomarker for Early-Stage Hepatocellular Carcinoma.

    Science.gov (United States)

    Naboulsi, Wael; Megger, Dominik A; Bracht, Thilo; Kohl, Michael; Turewicz, Michael; Eisenacher, Martin; Voss, Don Marvin; Schlaak, Jörg F; Hoffmann, Andreas-Claudius; Weber, Frank; Baba, Hideo A; Meyer, Helmut E; Sitek, Barbara

    2016-01-04

    Hepatocellular carcinoma (HCC) is one of the most aggressive tumors, and the treatment outcome of this disease is improved when the cancer is diagnosed at an early stage. This requires biomarkers allowing an accurate and early tumor diagnosis. To identify potential markers for such applications, we analyzed a patient cohort consisting of 50 patients (50 HCC and 50 adjacent nontumorous tissue samples as controls) using two independent proteomics approaches. We performed label-free discovery analysis on 19 HCC and corresponding tissue samples. The data were analyzed considering events known to take place in early events of HCC development, such as abnormal regulation of Wnt/b-catenin and activation of receptor tyrosine kinases (RTKs). 31 proteins were selected for verification experiments. For this analysis, the second set of the patient cohort (31 HCC and corresponding tissue samples) was analyzed using selected (multiple) reaction monitoring (SRM/MRM). We present the overexpression of ATP-dependent RNA helicase (DDX39), Fibulin-5 (FBLN5), myristoylated alanine-rich C-kinase substrate (MARCKS), and Serpin H1 (SERPINH1) in HCC for the first time. We demonstrate Versican core protein (VCAN) to be significantly associated with well differentiated and low-stage HCC. We revealed for the first time the evidence of VCAN as a potential biomarker for early-HCC diagnosis.

  10. Analysis of the potential geochemical reactions in the Enceladus' hydrothermal environment

    Science.gov (United States)

    Ramirez-Cabañas, A. K.; Flandes, A.

    2017-12-01

    Enceladus is the sixth largest moon of Saturn and differs from its other moons, because of its cryovolcanic geysers that emanate from its south pole. The instruments of the Cassini spacecraft reveal different compounds in the gases and the dust of the geysers, such as salts (sodium chloride, sodium bicarbonate and/or sodium carbonate), as well as silica traces (Postberg et al., 2008, 2009) that could be the result of a hydrothermal environment (Hsu et al., 2014, Sekine et al., 2014). By means of a thermodynamic analysis, we propose and evaluate potential geochemical reactions that could happen from the interaction between the nucleus surface and the inner ocean of Enceladus. These reactions may well lead to the origin of the compounds found in the geysers. From this analysis, we propose that, at least, two minerals must be present in the condritic nucleus of Enceladus: olivines (fayalite and fosterite) and feldspar (orthoclase and albite). Subsequently, taking as reference the hydrothermal processes that take place on Earth, we propose the different stages of a potential hydrothermal scenario for Enceladus.

  11. Analysis of Self-Potential Response beyond the Fixed Geometry Technique

    Science.gov (United States)

    Mahardika, Harry

    2018-03-01

    The self-potential (SP) method is one of the oldest geophysical methods that are still available for today’s application. Since its early days SP data interpretation has been done qualitatively until the emerging of the fixed geometry analysis that was used to characterize the orientation and the electric-dipole properties of a mineral ore structure. Through the expansion of fundamental theories, computational methods, field-and-lab experiments in the last fifteen years, SP method has emerge from its low-class reputation to become more respectable. It became a complementary package alongside electric-resistivity tomography (ERT) for detecting groundwater flow in the subsurface, and extends to the hydrothermal flow in geothermal areas. As the analysis of SP data becomes more quantitative, its potential applications become more diverse. In this paper, we will show examples of our current SP studies such as the groundwater flow characterization inside a fault area. Lastly we will introduce the application of the "active" SP method - that is the seismoelectric method - which can be used for 4D real-time monitoring systems.

  12. Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Mingbao Lin

    2013-01-01

    Full Text Available Chlorogenic acid (CGA widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive. Therefore, the aim of this study was to evaluate its potential sensitization systematically using meta-analysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria. In ASA test, odds ratio of behavior changes was 4.33 (1.62, 11.60, showing significant changes after CGA treatment (P=0.004. Serum IgG, serum histamine, PLN cellularity, and IgG1 AFCs were significantly enhanced after CGA treatment (P<0.05. Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices.

  13. Discovery of Acupoints and Combinations with Potential to Treat Vascular Dementia: A Data Mining Analysis

    Directory of Open Access Journals (Sweden)

    Shuwei Feng

    2015-01-01

    Full Text Available The prevalence of vascular dementia (VaD is high among the elderly. Acupuncture, a popular therapeutic method in China, can improve memory, orientation, calculation, and self-managing ability in VaD patients. However, in clinical acupuncture and acupuncture research, the selection of acupoints to treat VaD remains challenging. This study aimed to discover acupoints and acupoint combinations with potential for VaD based on data mining. After database searching and screening for articles on clinical trials evaluating the effects of acupuncture on VaD, 238 acupuncture prescriptions were included for further analysis. Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shuigou (GV 26, and Shenting (GV 24 appeared most frequently in the modern literature and are potential acupoints for VaD. Combinations between Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shenting (GV 24, Shuigou (GV 26, and Zusanli (ST 36 were most frequent and represent potential combinations for VaD treatment. These results provide a reference for the selection and combination of acupoints to treat VaD in clinical acupuncture and acupuncture research.

  14. Potential Analysis of Promoting the Dengue Hemorrhagic Fever Prevention Through Youtube

    Directory of Open Access Journals (Sweden)

    Mara Ipa

    2014-11-01

    Full Text Available Background: Deal with health promotion efforts in terms of disease control using media or social networking is an innovative breakthrough in a region having a broad range of territory, such as Indonesia and others countries alike. The use of social media /video platforms such as youtube, vimeo, veoh in health promotion has been significantly increased. This study aims to determine the potential availability of information about dengue hemorrhagic fever (DHF on YouTube social media and social media potential of as a medium for dissemination of knowledge of health promotion. Methods: This study used a social media site or website which is the most popular video hosting sites in the world, ‘YouTube’, with the keyword of ‘dengue hemorrhagic fever’. The selected video directly associated with DHF, videos in English that were included in this study using Latin letters in the description of the video; with duration less than or equal to 5 minutes. 76 videos analyzed with content analysis methods. Results:Showed that 76 videos divided into categories of prevention, control, transmission, treatment, dengue fever treatment, and other categories. Other information classification categories explain the severity of dengue virus infection, dengue vector (morphology, bionomics, intrinsic phase dengue virus and some research conducted as dengue vaccine discovery efforts. Conclusion: The availability of information about dengue on YouTube social media is still very deficient. Recommendation: YouTube has the potential of social media as a medium for disseminating health promotion information about dengue.

  15. Potential of FTIR spectroscopy for analysis of tears for diagnosis purposes.

    Science.gov (United States)

    Travo, Adrian; Paya, Clément; Déléris, Gérard; Colin, Joseph; Mortemousque, Bruno; Forfar, Isabelle

    2014-04-01

    It has been widely reported that the tear film, which is crucially important as a protective barrier of the eye, undergoes biochemical changes as a result of a wide range of ocular pathology. This tends to suggest the possibility of early detection of ocular diseases on the basis of biochemical analysis of tears. However, studies of tears by conventional methods of biomolecular and biochemical analysis are often limited by methodological difficulties. Moreover, such analysis could not be applied in the clinic, where structural and morphological analyses by, mainly, slit-lamp biomicroscopy remains the recommended method. In this study, we assessed, for the first time, the potential of FTIR spectroscopy combined with advanced chemometric processing of spectral data for analysis of raw tears for diagnosis purposes. We first optimized sampling and spectral acquisition (tears collection method, tear sample volume, and preservation of the samples) for accurate spectral measurement. On the basis of the results, we focused our study on the possibility of discriminating tears from normal individuals from those of patients with different ocular pathologies, and showed that the most discriminating spectral range is that corresponding to variations of CH2 and CH3 of lipid aliphatic chains. We also report more subtle discrimination of tears from patients with keratoconus and those from patients with non-specific inflammatory ocular diseases, on the basis of variations in spectral ranges attributed notably to lipid and carbohydrate vibrations. Finally, we also succeeded in distinguishing tears from patients with early-stage and late-stage keratoconus on the basis of spectral features attributed to protein structure. Therefore, this study strongly suggests that FTIR spectral analysis of tears could be developed as a valuable and cost-saving tool for biochemical-based detection of ocular diseases, potentially before the appearance of the first morphological signs of diseases

  16. A simple analysis of potential radiological exposure from geological disposal of Canada's nuclear fuel waste

    International Nuclear Information System (INIS)

    Amiro, B.D.; Dormuth, K.W.

    1996-02-01

    AECL has submitted an environmental impact statement (EIS) describing its proposal for geological disposal of Canada's nuclear fuel waste. The EIS presents a detailed analysis of potential radiation exposure of an individual of a critical group of people in a hypothetical case. In this report, we provide a simpler analysis of potential exposure in the hope that the inherent safety of the disposal will be more readily evident from the analysis. A key to the simplification is the elimination from the analysis of the complex transport processes through disposal vault sealing materials and the geosphere. We also eliminate the relatively complex function describing the failure of the thin-walled titanium containers in the case study presented in the EIS. We therefore conceptually replace the thin-walled titanium containers with thicker-walled copper containers, are expected to remain intact much longer than 10,000 a, the period for which a quantitative estimate of individual exposure is made. However, about 1 in 5000 containers could have small defects that were undetected during manufacture. Our analysis applies only to the case of an undisrupted vault. We assume that the vault and geosphere barriers remain intact and prevent immobile radionuclides from reaching the biosphere. However, we also assume that the three most important mobile radionuclides can escape through an undected manufacturing defect in the container wall, and that the flux of these radionuclides is diluted by well water being used by people. We have focused on 129 I, 36 Cl and 14 C, because these nuclides are found to be the dominant source of exposure in more complex analyses. If a single container released radionuclides to well water, we estimate dose rates of about 1 μSv.a -1 from drinking water and 29 μSv.a -1 , which the Atomic Eenrgy Control Board has adopted as a de minimis dose rate, i.e., a dose rate so small as to not warrant institutional control. We believe that the dose rates are

  17. Macroalgae Analysis A National GIS-based Analysis of Macroalgae Production Potential Summary Report and Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    Roesijadi, Guritno; Coleman, Andre M.; Judd, Chaeli; Van Cleve, Frances B.; Thom, Ronald M.; Buenau, Kate E.; Tagestad, Jerry D.; Wigmosta, Mark S.; Ward, Jeffrey A.

    2011-12-01

    The overall project objective is to conduct a strategic analysis to assess the state of macroalgae as a feedstock for biofuels production. The objective in FY11 is to develop a multi-year systematic national assessment to evaluate the U.S. potential for macroalgae production using a GIS-based assessment tool and biophysical growth model developed as part of these activities. The initial model development for both resource assessment and constraints was completed and applied to the demonstration areas. The model for macroalgal growth was extended to the EEZ off the East and West Coasts of the United States, and a plan to merge the findings for an initial composite assessment was developed. In parallel, an assessment of land-based, port, and offshore infrastructure needs based on published and grey literature was conducted. Major information gaps and challenges encountered during this analysis were identified. Also conducted was an analysis of the type of local, state, and federal requirements that pertain to permitting land-based facilities and nearshore/offshore culture operations

  18. Potential Indoor Worker Exposure From Handling Area Leakage: Dose Calculation Methodology and Example Consequence Analysis

    International Nuclear Information System (INIS)

    Nes, Razvan; Benke, Roland R.

    2008-01-01

    The U.S. Department of Energy (DOE) is currently considering design options for preclosure facilities in a license application for a geologic repository for spent nuclear fuel and high-level radioactive waste at Yucca Mountain, Nevada. The Center for Nuclear Waste Regulatory Analyses (CNWRA) developed the PCSA Tool Version 3.0.0 software for the U.S. Nuclear Regulatory Commission (NRC) to aid in the regulatory review of a potential DOE license application. The objective of this paper is to demonstrate PCSA Tool modeling capabilities (i.e., a generic two-compartment, mass-balance model) for estimating radionuclide concentrations in air and radiological dose consequences to indoor workers in a control room from potential leakage of radioactively contaminated air from an adjacent handling area. The presented model computes internal and external worker doses from inhalation and submersion in a finite cloud of contaminated air in the control room and augments previous capabilities for assessing indoor worker dose. As a complement to the example event sequence frequency analysis in the companion paper, example consequence calculations are presented in this paper for the postulated event sequence. In conclusion: this paper presents a model for estimating radiological doses to indoor workers for the leakage of airborne radioactive material from handling areas. Sensitivity of model results to changes in various input parameters was investigated via illustrative example calculations. Indoor worker dose estimates were strongly dependent on the duration of worker exposure and the handling-area leakage flow rate. In contrast, doses were not very sensitive to handling-area exhaust ventilation flow rates. For the presented example, inhalation was the dominant radiological dose pathway. The two companion papers demonstrate independent analysis capabilities of the regulator for performing confirmatory calculations of frequency and consequence, which assist the assessment of worker

  19. Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors

    DEFF Research Database (Denmark)

    Ebbesen, M F; Whitehead, Bradley Joseph; Gonzalez, Borja Ballarin

    2013-01-01

    and cellular interactions. Methods: Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared with a hydrophilic PEGylated "nano-shield" inserted at different levels by hydrophobic anchoring using either a phospholipid-PEG conjugate or the copolymer PLGA-block-PEG by an emulsification/diffusion method....... Surface and bulk analysis was performed including X-ray photoelectron spectroscopy (XPS), nuclear magnetic resonance spectroscopy (NMR) and zeta potential. Cellular uptake was investigated in RAW 264.7 macrophages by flow cytometry. Results: Sub-micron nanoparticles were formed and the combination of (NMR...

  20. Potential Indoor Worker Exposure From Handling Area Leakage: Example Event Sequence Frequency Analysis

    International Nuclear Information System (INIS)

    Benke, Roland R.; Adams, George R.

    2008-01-01

    The U.S. Department of Energy (DOE) is currently considering design options for the facilities that will handle spent nuclear fuel and high-level radioactive waste at the potential nuclear waste repository at Yucca Mountain, Nevada. The license application must demonstrate compliance with the performance objectives of 10 CFR Part 63, which include occupational dose limits from 10 CFR Part 20. If DOE submits a license application under 10 CFR Part 63, the U.S. Nuclear Regulatory Commission (NRC) will conduct a risk-informed, performance-based review of the DOE license application and its preclosure safety analysis, in which in-depth technical evaluations are focused on technical areas that are significant to preclosure safety and risk. As part of pre-licensing activities, the Center for Nuclear Waste Regulatory Analyses (CNWRA) developed the Preclosure Safety Analysis Tool software to aid in the regulatory review of a DOE license application and support any independent confirmatory assessments that may be needed. Recent DOE information indicates a primarily canister-based handling approach that includes the wet transfer of individual assemblies where Heating, Ventilation, and Air Conditioning (HVAC) systems may be relied on to provide confinement and limit the spread of any airborne radioactive material from handling operations. Workers may be involved in manual and remote operations in handling transportation casks, canisters, waste packages, or bare spent nuclear fuel assemblies inside facility buildings. As part of routine operations within these facilities, radioactive material may potentially become airborne if canisters are opened or bare fuel assemblies are handled. Leakage of contaminated air from the handling area into adjacent occupied areas, therefore, represents a potential radiological exposure pathway for indoor workers. The objective of this paper is to demonstrate modeling capabilities that can be used by the regulator to estimate frequencies of

  1. Tracing the Potential Flow of Consumer Data: A Network Analysis of Prominent Health and Fitness Apps.

    Science.gov (United States)

    Grundy, Quinn; Held, Fabian P; Bero, Lisa A

    2017-06-28

    A great deal of consumer data, collected actively through consumer reporting or passively through sensors, is shared among apps. Developers increasingly allow their programs to communicate with other apps, sensors, and Web-based services, which are promoted as features to potential users. However, health apps also routinely pose risks related to information leaks, information manipulation, and loss of information. There has been less investigation into the kinds of user data that developers are likely to collect, and who might have access to it. We sought to describe how consumer data generated from mobile health apps might be distributed and reused. We also aimed to outline risks to individual privacy and security presented by this potential for aggregating and combining user data across apps. We purposively sampled prominent health and fitness apps available in the United States, Canada, and Australia Google Play and iTunes app stores in November 2015. Two independent coders extracted data from app promotional materials on app and developer characteristics, and the developer-reported collection and sharing of user data. We conducted a descriptive analysis of app, developer, and user data collection characteristics. Using structural equivalence analysis, we conducted a network analysis of sampled apps' self-reported sharing of user-generated data. We included 297 unique apps published by 231 individual developers, which requested 58 different permissions (mean 7.95, SD 6.57). We grouped apps into 222 app families on the basis of shared ownership. Analysis of self-reported data sharing revealed a network of 359 app family nodes, with one connected central component of 210 app families (58.5%). Most (143/222, 64.4%) of the sampled app families did not report sharing any data and were therefore isolated from each other and from the core network. Fifteen app families assumed more central network positions as gatekeepers on the shortest paths that data would have to

  2. Metagenomic analysis indicates Epsilonproteobacteria as a potential cause of microbial corrosion in pipelines injected with bisulfite

    Directory of Open Access Journals (Sweden)

    Dongshan eAn

    2016-01-01

    Full Text Available Sodium bisulfite (SBS is used as an oxygen scavenger to decrease corrosion in pipelines transporting brackish subsurface water used in the production of bitumen by steam-assisted gravity drainage. Sequencing 16S rRNA gene amplicons has indicated that SBS addition increased the fraction of the sulfate-reducing bacteria (SRB Desulfomicrobium, as well as of Desulfocapsa, which can also grow by disproportionating sulfite into sulfide, sulfur and sulfate. SRB use cathodic H2, formed by reduction of aqueous protons at the iron surface, or use low potential electrons from iron and aqueous protons directly for sulfate reduction. In order to reveal the effects of SBS treatment in more detail, metagenomic analysis was performed with pipe-associated solids (PAS scraped from a pipe section upstream (PAS-616P and downstream (PAS-821TP of the SBS injection point. A major SBS-induced change in microbial community composition and in affiliated hynL genes for the large subunit of [NiFe] hydrogenase was the appearance of sulfur-metabolizing Epsilonproteobacteria of the genera Sulfuricurvum and Sulfurovum. These are chemolithotrophs, which oxidize sulfide or sulfur with O2 or reduce sulfur with H2. Because O2 was absent, this class likely catalyzed reduction of sulfur (S0 originating from the metabolism of bisulfite with cathodic H2 (or low potential electrons and aqueous protons originating from the corrosion of steel (Fe0. Overall this accelerates reaction of of S0 and Fe0 to form FeS, making this class a potentially powerful contributor to microbial corrosion. The PAS-821TP metagenome also had increased fractions of Deltaproteobacteria including the SRB Desulfomicrobium and Desulfocapsa. Altogether, SBS increased the fraction of hydrogen-utilizing Delta- and Epsilonproteobacteria in brackish-water-transporting pipelines, potentially stimulating anaerobic pipeline corrosion if dosed in excess of the intended oxygen scavenger function.

  3. Potential Coastal Pumped Hydroelectric Energy Storage Locations Identified using GIS-based Topographic Analysis

    Science.gov (United States)

    Parsons, R.; Barnhart, C. J.; Benson, S. M.

    2013-12-01

    Large-scale electrical energy storage could accommodate variable, weather dependent energy resources such as wind and solar. Pumped hydroelectric energy storage (PHS) and compressed energy storage area (CAES) have life cycle energy and financial costs that are an order of magnitude lower than conventional electrochemical storage technologies. However PHS and CAES storage technologies require specific geologic conditions. Conventional PHS requires an upper and lower reservoir separated by at least 100 m of head, but no more than 10 km in horizontal distance. Conventional PHS also impacts fresh water supplies, riparian ecosystems, and hydrologic environments. A PHS facility that uses the ocean as the lower reservoir benefits from a smaller footprint, minimal freshwater impact, and the potential to be located near off shore wind resources and population centers. Although technologically nascent, today one coastal PHS facility exists. The storage potential for coastal PHS is unknown. Can coastal PHS play a significant role in augmenting future power grids with a high faction of renewable energy supply? In this study we employ GIS-based topographic analysis to quantify the coastal PHS potential of several geographic locations, including California, Chile and Peru. We developed automated techniques that seek local topographic minima in 90 m spatial resolution shuttle radar topography mission (SRTM) digital elevation models (DEM) that satisfy the following criteria conducive to PHS: within 10 km from the sea; minimum elevation 150 m; maximum elevation 1000 m. Preliminary results suggest the global potential for coastal PHS could be very significant. For example, in northern Chile we have identified over 60 locations that satisfy the above criteria. Two of these locations could store over 10 million cubic meters of water or several GWh of energy. We plan to report a global database of candidate coastal PHS locations and to estimate their energy storage capacity.

  4. The potential estimation and factor analysis of China′s energy conservation on thermal power industry

    International Nuclear Information System (INIS)

    Lin, Boqiang; Yang, Lisha

    2013-01-01

    At present, researches about energy conservation are focused on prediction. But there are few researches focused on the estimation of effective input and energy conservation potential, and there has been even no research on energy conservation of thermal power industry of China. This paper will try to fill in such a blank. Panel data on Chinese thermal power industry over 2005–2010 are established, and we adopt the stochastic frontier analysis approach to estimate the energy saving potential of thermal power industry. The results are as follows: (1) the average efficiency of energy inputs in China′s thermal power industry over 2005–2010 was about 0.85, and cumulative energy saving potential equals to 551.04 (Mtce); (2) by improving the non-efficiency factors, the relatively backward inland cities could achieve higher energy saving in thermal power industry; (3) the energy input efficiency of Eastern China Grid is shown to be the highest; (4) in order to realize the energy-saving goal of thermal power industry, one important policy method the government should adopt is to conduct a market-oriented reform in power industry and break the state-owned monopoly to provide incentives for private and foreign direct investment in thermal power sector. -- Highlights: •We adopt SFA model to estimate the coal input efficiency of power sector in China. •We calculate the cumulative energy saving potential equals to 551.04 Mtce. •East China power grid has the highest energy input efficiency. •Some backward inland cities may be the main force for future energy conservation. •Encourage private and foreign direct investment in power sector might be effective

  5. Estimating global mortality from potentially foodborne diseases: an analysis using vital registration data

    Directory of Open Access Journals (Sweden)

    Hanson Laura A

    2012-03-01

    Full Text Available Abstract Background Foodborne diseases (FBD comprise a large part of the global mortality burden, yet the true extent of their impact remains unknown. The present study utilizes multiple regression with the first attempt to use nonhealth variables to predict potentially FBD mortality at the country level. Methods Vital registration (VR data were used to build a multiple regression model incorporating nonhealth variables in addition to traditionally used health indicators. This model was subsequently used to predict FBD mortality rates for all countries of the World Health Organization classifications AmrA, AmrB, EurA, and EurB. Results Statistical modeling strongly supported the inclusion of nonhealth variables in a multiple regression model as predictors of potentially FBD mortality. Six variables were included in the final model: percent irrigated land, average calorie supply from animal products, meat production in metric tons, adult literacy rate, adult HIV/AIDS prevalence, and percent of deaths under age 5 caused by diarrheal disease. Interestingly, nonhealth variables were not only more robust predictors of mortality than health variables but also remained significant when adding additional health variables into the analysis. Mortality rate predictions from our model ranged from 0.26 deaths per 100,000 (Netherlands to 15.65 deaths per 100,000 (Honduras. Reported mortality rates of potentially FBD from VR data lie within the 95% prediction interval for the majority of countries (37/39 where comparison was possible. Conclusions Nonhealth variables appear to be strong predictors of potentially FBD mortality at the country level and may be a powerful tool in the effort to estimate the global mortality burden of FBD. Disclaimer The views expressed in this document are solely those of the authors and do not represent the views of the World Health Organization.

  6. Scenario analysis on CO2 emissions reduction potential in China's iron and steel industry

    International Nuclear Information System (INIS)

    Wang Ke; Wang Can; Lu Xuedu; Chen Jining

    2007-01-01

    The international climate community has begun to assess a range of possible options for strengthening the international climate change effort after 2012. Analysis of the potential for sector-based emissions reduction and relevant mitigation options will provide the necessary background information for the debate. In order to assess the CO 2 abatement potential of China's steel industry, a model was developed using LEAP software to generate 3 different CO 2 emission scenarios for the industry from 2000 to 2030. The abatement potentials of different scenarios were compared, and their respective feasibilities were assessed according to the cost information. High priority abatement measures were then identified. The results show that the average CO 2 abatement per year in the Recent Policy scenario and in the New Policy scenario, compared with the reference scenario, are 51 and 107 million tons, respectively. The corresponding total incremental costs are 9.34 and 80.95 billion dollars. It is concluded that there is great potential for CO 2 abatement in China's steel industry. Adjusting the structure of the industry and technological advancement will play an important role in emissions reduction. Successful implementation of current sustainable development policies and measures will result in CO 2 abatement at a low cost. However, to achieve higher levels of abatement, the cost will increase dramatically. In the near future, specific energy conservation technologies such as dry coke quenching, exhaust gas and heat recovery equipment will be of great significance. However, taking a long term perspective, emissions reduction will rely more on the adjustment of production processes and the application of more modern large scale plants. Advanced blast furnace technology will inevitably play an important role

  7. Sedimentary basin analysis and petroleum potential of the Cretaceous and Tertiary strata in Korea.

    Energy Technology Data Exchange (ETDEWEB)

    Son, Jin-Dam; Kwak, Young-Hoon; Bong, Pil-Yoon [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

    1999-12-01

    Since 1992 sedimentary basin analysis to assess petroleum potential of the Cretaceous and Tertiary strata in the Korean onshore and continental shelf have been carried out. The Cretaceous non-marine strata mainly occupy the Gyeongsang Basin in southeastern part of the Korean Peninsula and small basins such as Haenam and Gyeokpo depressions in western coastal areas. The Tertiary strata are mostly distributed in Domi, Cheju, Socotra subbasins, and Okinawa Trough in the South Continental Shelf, and Kunsan and Heuksan basins in the West. The basin evolution and petroleum potential for each basins are characterized as follow. The Cretaceous Gyeongsang sediments were deposited in three subbasins including Milyang, Euisung and Yongyang subbasins. The black shales in Nakdong and Jinju formations are interpreted to contain abundant organic matter during the deposition, thermal maturity reaching up to the zone of dry gas formation. Because porosity and permeability are too low, the sandstones can act as a tight gas reservoir rather than conventional oil and gas reservoir. The latest Cretaceous strata of Haenam and Kyeokpo depressions in western coastal area are correlated into the Yuchon Volcanic Group of the Gyeongsang Basin. Petroleum potential of the Early Cretaceous basin in the West Continental Shelf could be relatively high in terms of sedimentary basin filled with thick lacustrine sediments. The Kunsan basin in the West Continental Shelf originated in the Early Cretaceous time expanded during the Paleocene time followed by regional erosion at the end of Paleocene on which Neogene sediment have been accumulated. The Paleocene-Eocene sublacustrine shales may play an major role as a source and cap rocks. South Continental Shelf Basin is subdivided by Cheju subbasin in the center, Socotra Subbasin to the west, Domi Subbasin to the northeast and Okinawa Trough to the East. The potential hydrocarbon traps associated with anticline, titled fault blocks, fault, unconformity

  8. ARCHITECTURE AND FUNCTIONALITY OF INTEGRATED INFORMATION SYSTEM FOR ANALYSIS OF POTENTIAL OF RENEWABLE ENERGY SOURCES

    Directory of Open Access Journals (Sweden)

    B. A. Tonkonogov

    2017-01-01

    Full Text Available The aim of the work was the development of the original architecture of an integrated information system for analysis of the potential of renewable energy sources. The required functionality of system has led to the solution of a number of problems in the development of appropriate software modules that implement methods, models and algorithms for assessing the energy potential and economic efficiency of the use of renewable energy sources (RES. This required the solution of the following problems: adaptation of existing and development of new methods for analyzing the potential of RES at various territorial levels using modern technologies of geographic information systems and computer technologies were accomplished; models for the assessment and calculation of the potential of renewable energy resources were developed; techniques for assessing of the economic effectiveness of decisions made for using of RES were adapted; architecture of the information system was developed and the choice of technologies and means for its implementation was made; algorithms of software modules and their interaction as a parts of the information system were developed. A distinctive feature of the architecture were flexibility and openness for the expansion and implementation of additional functionality, in particular the development of special algorithms and software modules for interacting with the database and a graphical Web-based user interface that provides the ability to work with cartographic information. The development and implementation of this system is a modern up-to-date scientific and practical task, the solution of which will create conditions for increased use of RES in RB and improving the country’s energy security. The results of conducted researches and completed developments can be used in the system of the Ministry of Natural Resources and Environmental Protection of RB, in particular for maintaining of the state cadastre of RES and making

  9. Identification of potential opinion leaders in child health promotion in Sweden using network analysis.

    Science.gov (United States)

    Guldbrandsson, Karin; Nordvik, Monica K; Bremberg, Sven

    2012-08-08

    Opinion leaders are often local individuals with high credibility who can influence other people. Robust effects using opinion leaders in diffusing innovations have been shown in several randomized controlled trials, for example regarding sexually transmitted infections (STI), human immunodeficiency virus (HIV) prevention, mammography rates and caesarean birth delivery rates. In a Cochrane review 2010 it was concluded that the use of opinion leaders can successfully promote evidence-based practice. Thus, using opinion leaders within the public health sector might be one means to speed up the dissemination of health promoting and disease preventing innovations. Social network analysis has been used to trace and map networks, with focus on relationships and positions, in widely spread arenas and topics. The purpose of this study was to use social network analysis in order to identify potential opinion leaders at the arena of child health promotion in Sweden. By using snowball technique a short e-mail question was spread in up to five links, starting from seven initially invited persons. This inquiry resulted in a network consisting of 153 individuals. The most often mentioned actors were researchers, public health officials and paediatricians, or a combination of these professions. Four single individuals were mentioned by five to seven other persons in the network. These individuals obviously possess qualities that make other professionals within the public health sector listen to and trust them. Social network analysis seemed to be a useful method to identify influential persons with high credibility, i.e. potential opinion leaders, at the arena of child health promotion in Sweden. If genuine opinion leaders could be identified directed measures can be carried out in order to spread new and relevant knowledge. This may facilitate for public health actors at the local, regional and national level to more rapidly progress innovations into everyday practice. However

  10. Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

    Directory of Open Access Journals (Sweden)

    Fikret Emre eKapucu

    2012-06-01

    Full Text Available In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESC, exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing statistics based on interspike interval (ISI histograms. Moreover, the algorithm calculates interspike interval thresholds for burst spikes as well as for pre-burst spikes and burst tails by evaluating the cumulative moving average and skewness of the ISI histogram. Because of the adaptive nature of the proposed algorithm, its analysis power is not limited by the type of neuronal cell network at hand. We demonstrate the functionality of our algorithm with two different types of microelectrode array (MEA data recorded from spontaneously active hESC-derived neuronal cell networks. The same data was also analyzed by two commonly employed burst detection algorithms and the differences in burst detection results are illustrated. The results demonstrate that our method is both adaptive to the firing statistics of the network and yields successful burst detection from the data. In conclusion, the proposed method is a potential tool for analyzing of hESC-derived neuronal cell networks and thus can be utilized in studies aiming to understand the development and functioning of human neuronal networks and as an analysis tool for in vitro drug screening and neurotoxicity assays.

  11. Urine proteome analysis in Dent's disease shows high selective changes potentially involved in chronic renal damage.

    Science.gov (United States)

    Santucci, Laura; Candiano, Giovanni; Anglani, Franca; Bruschi, Maurizio; Tosetto, Enrica; Cremasco, Daniela; Murer, Luisa; D'Ambrosio, Chiara; Scaloni, Andrea; Petretto, Andrea; Caridi, Gianluca; Rossi, Roberta; Bonanni, Alice; Ghiggeri, Gian Marco

    2016-01-01

    Definition of the urinary protein composition would represent a potential tool for diagnosis in many clinical conditions. The use of new proteomic technologies allows detection of genetic and post-trasductional variants that increase sensitivity of the approach but complicates comparison within a heterogeneous patient population. Overall, this limits research of urinary biomarkers. Studying monogenic diseases are useful models to address this issue since genetic variability is reduced among first- and second-degree relatives of the same family. We applied this concept to Dent's disease, a monogenic condition characterised by low-molecular-weight proteinuria that is inherited following an X-linked trait. Results are presented here on a combined proteomic approach (LC-mass spectrometry, Western blot and zymograms for proteases and inhibitors) to characterise urine proteins in a large family (18 members, 6 hemizygous patients, 6 carrier females, and 6 normals) with Dent's diseases due to the 1070G>T mutation of the CLCN5. Gene ontology analysis on more than 1000 proteins showed that several clusters of proteins characterised urine of affected patients compared to carrier females and normal subjects: proteins involved in extracellular matrix remodelling were the major group. Specific analysis on metalloproteases and their inhibitors underscored unexpected mechanisms potentially involved in renal fibrosis. Studying with new-generation techniques for proteomic analysis of the members of a large family with Dent's disease sharing the same molecular defect allowed highly repetitive results that justify conclusions. Identification in urine of proteins actively involved in interstitial matrix remodelling poses the question of active anti-fibrotic drugs in Dent's patients. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Global analysis of the techno-economic potential of renewable energy hybrid systems on small islands

    International Nuclear Information System (INIS)

    Blechinger, P.; Cader, C.; Bertheau, P.; Huyskens, H.; Seguin, R.; Breyer, C.

    2016-01-01

    Globally, small islands below 100,000 inhabitants represent a large number of diesel based mini-grids. With volatile fossil fuel costs which are most likely to increase in the long-run and competitive renewable energy technologies the introduction of such sustainable power generation system seems a viable and environmental friendly option. Nevertheless the implementation of renewable energies on small islands is quite low based on high transaction costs and missing knowledge according to the market potential. Our work provides a global overview on the small island landscape showing the respective population, economic activity, energy demand, and fuel costs for almost 1800 islands with approximately 20 million inhabitants currently supplied by 15 GW of diesel plants. Based on these parameters a detailed techno-economic assessment of the potential integration of solar PV, wind power, and battery storage into the power supply system was performed for each island. The focus on solar and wind was set due to the lack of data on hydro and geothermal potential for a global island study. It revealed that almost 7.5 GW of photovoltaic and 14 GW of wind power could be economically installed and operated on these islands reducing the GHG-emissions and fuel consumption by approximately 50%. In total numbers more than 20 million tons of GHG emissions can be reduced by avoiding the burning of 7.8 billion liters of diesel per year. Cost savings of around 9 USDct/kWh occur on average by implementing these capacities combined with 5.8 GWh of battery storage. This detailed techno-economic evaluation of renewable energies enables policy makers and investors to facilitate the implementation of clean energy supply systems on small islands. To accelerate the implementation of this enormous potential we give specific policy recommendations such as the introduction of proper regulations. - Highlights: • GIS analysis has identified approximately 1800 small island energy systems with

  13. Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

    Directory of Open Access Journals (Sweden)

    Ubadah Sabbagh

    2016-01-01

    Full Text Available The purpose of this study was to find genes linked with eating disorders and associated with both metabolic and neural systems. Our operating hypothesis was that there are genetic factors underlying some eating disorders resting in both those pathways. Specifically, we are interested in disorders that may rest in both sleep and metabolic function, generally called Night Eating Syndrome (NES. A meta-analysis of the Gene Expression Omnibus targeting the mammalian nervous system, sleep, and obesity studies was performed, yielding numerous genes of interest. Through a text-based analysis of the results, a number of potential candidate genes were identified. VGF, in particular, appeared to be relevant both to obesity and, broadly, to brain or neural development. VGF is a highly connected protein that interacts with numerous targets via proteolytically digested peptides. We examined VGF from an evolutionary perspective to determine whether other available evidence supported a role for the gene in human disease. We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity. Our data suggest that there is enough evidence to warrant eGWAS and GWAS analysis of these genes in NES patients in a case-control study.

  14. Practical In-Depth Analysis of IDS Alerts for Tracing and Identifying Potential Attackers on Darknet

    Directory of Open Access Journals (Sweden)

    Jungsuk Song

    2017-02-01

    Full Text Available The darknet (i.e., a set of unused IP addresses is a very useful solution for observing the global trends of cyber threats and analyzing attack activities on the Internet. Since the darknet is not connected with real systems, in most cases, the incoming packets on the darknet (‘the darknet traffic’ do not contain a payload. This means that we are unable to get real malware from the darknet traffic. This situation makes it difficult for security experts (e.g., academic researchers, engineers, operators, etc. to identify whether the source hosts of the darknet traffic are infected by real malware or not. In this paper, we present the overall procedure of the in-depth analysis between the darknet traffic and IDS alerts using real data collected at the Science and Technology Cyber Security Center (S&T CSC in Korea and provide the detailed in-depth analysis results. The ultimate goal of this paper is to provide practical experience, insight and know-how to security experts so that they are able to identify and trace the root cause of the darknet traffic. The experimental results show that correlation analysis between the darknet traffic and IDS alerts is very useful to discover potential attack hosts, especially internal hosts, and to find out what kinds of malware infected them.

  15. Regional analysis of potential energy production from agricultural wastes: technical and economic study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Have, H

    1981-01-01

    The possibilities for utilization of agricultural wastes for energy production are analyzed in two Danish counties, Ringkoebing and Vestsjaelland, which have different agricultural production patterns. The quantitative analysis shows that the major waste products, surplus straw, waste wood and animal waste, in total with present technique can cover about 28% of the demand for heat energy (mostly space heating) in both counties. The potential coverage from straw, wood and animal waste is about 3, 3 and 22% in Ringkoebing and 18, 2 and 8% in Vestsjaelland respectively. A technical analysis indicates that direct combustion is the most favorable conversion method for straw and wood while biological conversion at present is best suited for animal waste. An economic analysis based on costs of collection, storage, transport and conversion of wastes and costs of corresponding oil and oil conversion were made. From a community point of view only straw and wood are found to be competitive to the expensive gas fuel oil when burned in automatically stoked furnaces. From a heating station point of view waste utilization is more attractive because of the sales tax on oil products. Here straw and wood are competitive fuels to both gas and heavy fuel oil in all the analyzed systems except from the small manually stoked furnaces. Animal waste seems to be competitive only when replacing gas fuel oil in medium size (500 kW) well utilized aerobic fermenters.

  16. Hydrodynamic analysis of potential groundwater extraction capacity increase: case study of 'Nelt' groundwater source at Dobanovci

    Directory of Open Access Journals (Sweden)

    Bajić Dragoljub I.

    2017-01-01

    Full Text Available A comprehensive hydrodynamic analysis of the groundwater regime undertaken to assess the potential for expanding the 'Nelt' groundwater source at Dobanovci, or developing a new groundwater source for a future baby food factory, including the quantification of the impact on the production wells of the nearby 'Pepsi' groundwater source, is presented in the paper. The existing Nelt source is comprised of three active production wells that tap a subartesian aquifer formed in sands and gravelly sands; however, the analysis considers only the two nearest wells. A long-term group pumping test was con-ducted of production wells N-1 and N2 (Nelt source and production wells B-1 and B-2 (Pepsi source, while the piezometric head in the vicinity of these wells was monitored at observation well P-1, which is located in the area considered for Nelt source expansion. Data were collected at maximum pumping capacity of all the production wells. A hydrodynamic model of groundwater flow in the extended area of the Nelt source was generated for the purposes of the comprehensive hydrodynamic analysis. Hydrodynamic prognostic calculations addressed two solution alternatives for the capacity increase over a period of ten years. Licensed Visual MODFLOW Pro software, deemed to be at the very top in this field, was used for the calculations.

  17. Computer-assisted sperm morphometry fluorescence-based analysis has potential to determine progeny sex

    Directory of Open Access Journals (Sweden)

    Pilar Santolaria

    2016-01-01

    Full Text Available This study was designed to determine the ability of computer-assisted sperm morphometry analysis (CASA-Morph with fluorescence to discriminate between spermatozoa carrying different sex chromosomes from the nuclear morphometrics generated and different statistical procedures in the bovine species. The study was divided into two experiments. The first was to study the morphometric differences between X- and Y-chromosome-bearing spermatozoa (SX and SY, respectively. Spermatozoa from eight bulls were processed to assess simultaneously the sex chromosome by FISH and sperm morphometry by fluorescence-based CASA-Morph. SX cells were larger than SY cells on average (P < 0.001 although with important differences between bulls. A simultaneous evaluation of all the measured features by discriminant analysis revealed that nuclear area and average fluorescence intensity were the variables selected by stepwise discriminant function analysis as the best discriminators between SX and SY. In the second experiment, the sperm nuclear morphometric results from CASA-Morph in nonsexed (mixed SX and SY and sexed (SX semen samples from four bulls were compared. FISH allowed a successful classification of spermatozoa according to their sex chromosome content. X-sexed spermatozoa displayed a larger size and fluorescence intensity than nonsexed spermatozoa (P < 0.05. We conclude that the CASA-Morph fluorescence-based method has the potential to find differences between X- and Y-chromosome-bearing spermatozoa in bovine species although more studies are needed to increase the precision of sex determination by this technique.

  18. Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder.

    Science.gov (United States)

    Sabbagh, Ubadah; Mullegama, Saman; Wyckoff, Gerald J

    2016-01-01

    The purpose of this study was to find genes linked with eating disorders and associated with both metabolic and neural systems. Our operating hypothesis was that there are genetic factors underlying some eating disorders resting in both those pathways. Specifically, we are interested in disorders that may rest in both sleep and metabolic function, generally called Night Eating Syndrome (NES). A meta-analysis of the Gene Expression Omnibus targeting the mammalian nervous system, sleep, and obesity studies was performed, yielding numerous genes of interest. Through a text-based analysis of the results, a number of potential candidate genes were identified. VGF, in particular, appeared to be relevant both to obesity and, broadly, to brain or neural development. VGF is a highly connected protein that interacts with numerous targets via proteolytically digested peptides. We examined VGF from an evolutionary perspective to determine whether other available evidence supported a role for the gene in human disease. We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity. Our data suggest that there is enough evidence to warrant eGWAS and GWAS analysis of these genes in NES patients in a case-control study.

  19. Root-Cause Analysis of a Potentially Sentinel Transfusion Event: Lessons for Improvement of Patient Safety

    Directory of Open Access Journals (Sweden)

    Ali Reza Jeddian

    2012-09-01

    Full Text Available Errors prevention and patient safety in transfusion medicine are a serious concern. Errors can occur at any step in transfusion and evaluation of their root causes can be helpful for preventive measures. Root cause analysis as a structured and systematic approach can be used for identification of underlying causes of adverse events. To specify system vulnerabilities and illustrate the potential of such an approach, we describe the root cause analysis of a case of transfusion error in emergency ward that could have been fatal. After reporting of the mentioned event, through reviewing records and interviews with the responsible personnel, the details of the incident were elaborated. Then, an expert panel meeting was held to define event timeline and the care and service delivery problems and discuss their underlying causes, safeguards and preventive measures. Root cause analysis of the mentioned event demonstrated that certain defects of the system and the ensuing errors were main causes of the event. It also points out systematic corrective actions. It can be concluded that health care organizations should endeavor to provide opportunities to discuss errors and adverse events and introduce preventive measures to find areas where resources need to be allocated to improve patient safety.

  20. Quantitative analysis of potential currency crisis in the Republic of Serbia

    Directory of Open Access Journals (Sweden)

    Rađenović Žarko

    2015-01-01

    Full Text Available The subject of this paper is theoretical and empirical analysis of potential currency crisis in the Republic of Serbia. The main aim of the paper is quantitative analysis of a set of key indicators (index of exchange market pressure, signal-to-noise ratio, misery index, a measure of openness and the monetary measure of openness of the country that indicate the possibility of a currency crisis. The cyclic character of currency and financial crisis is forcing policymakers to conduct thoughtful exchange rate policy. The aim of this is to prevent the scenario with which the countries of Latin America faced in the late 20th century. Although there is no a significant correlation in terms of international trade transactions between Serbia and the countries of Latin America, we should certainly learn from the experience of these countries. It is necessary to continuously monitor the value of indicators which point to possible distortion. In the paper we use some econometric and statistical tools, such as correlation and regression analysis, to point to the values of indicators which can contribute to early detection of a currency crisis.

  1. Institutional Analysis of Knowledge Generation Resource Potential at the Enterprises of Regional Military-Industrial Complex

    Directory of Open Access Journals (Sweden)

    Evgeny Vasilyevich Popov

    2016-09-01

    Full Text Available The article is devoted to the processes of knowledge generation at the enterprises of military-industrial complex, which are the leaders of the regional innovative activity. The target of the research is to develop the methodology based on the use of resource application potential for increasing the efficiency of knowledge generation at the instrument-making enterprises of military-industrial complex. The system analysis of the knowledge generation processes is conducted at one of them. It allows to draw a conclusion that such enterprises have a lack of the institutes of knowledge generation processes. The authors are offered a technique of the development of the knowledge generation system at the military-industrial enterprises based on the accounting of assets and opportunities of the enterprise in the realization of intellectual activity. The developed technique is based on the determination of the horizontal resource potential of knowledge generation and allows to determine the potential of resource application at each stage of product life cycle. The comparison of the actual and theoretical values of horizontal resource potential allows to correct the distribution of a share of each of resources within a stage, and therefore, to optimize the realization of tasks at a specific stage. The offered tools were implemented in 2015 at one of the regional military-Industrial enterprises. The methodological tools of the research include the methods of expert assessment, mathematical statistics and the institutional analysis. On the basis of the offered technique and received empirical results, the institutional spiral of knowledge generation during the filling of state order at the military-industrial enterprise is developed. Its implementation will promote the decrease in the level of uncertainty during the whole life cycle of innovative activity product. The developed institutional spiral of knowledge generation at instrument-making military

  2. Estimating the potential intensification of global grazing systems based on climate adjusted yield gap analysis

    Science.gov (United States)

    Sheehan, J. J.

    2016-12-01

    We report here a first-of-its-kind analysis of the potential for intensification of global grazing systems. Intensification is calculated using the statistical yield gap methodology developed previously by others (Mueller et al 2012 and Licker et al 2010) for global crop systems. Yield gaps are estimated by binning global pasture land area into 100 equal area sized bins of similar climate (defined by ranges of rainfall and growing degree days). Within each bin, grid cells of pastureland are ranked from lowest to highest productivity. The global intensification potential is defined as the sum of global production across all bins at a given percentile ranking (e.g. performance at the 90th percentile) divided by the total current global production. The previous yield gap studies focused on crop systems because productivity data on these systems is readily available. Nevertheless, global crop land represents only one-third of total global agricultural land, while pasture systems account for the remaining two-thirds. Thus, it is critical to conduct the same kind of analysis on what is the largest human use of land on the planet—pasture systems. In 2013, Herrero et al announced the completion of a geospatial data set that augmented the animal census data with data and modeling about production systems and overall food productivity (Herrero et al, PNAS 2013). With this data set, it is now possible to apply yield gap analysis to global pasture systems. We used the Herrero et al data set to evaluate yield gaps for meat and milk production from pasture based systems for cattle, sheep and goats. The figure included with this abstract shows the intensification potential for kcal per hectare per year of meat and milk from global cattle, sheep and goats as a function of increasing levels of performance. Performance is measured as the productivity achieved at a given ranked percentile within each bin.We find that if all pasture land were raised to their 90th percentile of

  3. Analysis of vehicle exhaust waste heat recovery potential using a Rankine cycle

    International Nuclear Information System (INIS)

    Domingues, António; Santos, Helder; Costa, Mário

    2013-01-01

    This study evaluates the vehicle exhaust WHR (waste heat recovery) potential using a RC (Rankine cycle ). To this end, both a RC thermodynamic model and a heat exchanger model have been developed. Both models use as input, experimental data obtained from a vehicle tested on a chassis dynamometer. The thermodynamic analysis was performed for water, R123 and R245fa and revealed the advantage of using water as the working fluid in applications of thermal recovery from exhaust gases of vehicles equipped with a spark-ignition engine. Moreover, the heat exchanger effectiveness for the organic working fluids R123 and R245fa is higher than that for the water and, consequently, they can also be considered appropriate for use in vehicle WHR applications through RCs when the exhaust gas temperatures are relatively low. For an ideal heat exchanger, the simulations revealed increases in the internal combustion engine thermal and vehicle mechanical efficiencies of 1.4%–3.52% and 10.16%–15.95%, respectively, while for a shell and tube heat exchanger, the simulations showed an increase of 0.85%–1.2% in the thermal efficiency and an increase of 2.64%–6.96% in the mechanical efficiency for an evaporating pressure of 2 MPa. The results confirm the advantages of using the thermal energy contained in the vehicle exhaust gases through RCs. Furthermore, the present analysis demonstrates that improved evaporator designs and appropriate expander devices allowing for higher evaporating pressures are required to obtain the maximum WHR potential from vehicle RC systems. -- Highlights: ► This study evaluates the vehicle exhaust waste heat recovery potential using Rankine cycle systems. ► A thermodynamic model and a heat exchanger model were developed. ► Experimental data obtained in a vehicle tested on a chassis dynamometer was used as models input. ► Thermodynamic analysis was performed for water, R123 and R245fa. ► Results confirm advantages of using the thermal energy

  4. Case Series Analysis of New Zealand Reports of Rapid Intense Potentiation of Warfarin by Roxithromycin.

    Science.gov (United States)

    Savage, Ruth L; Tatley, Michael V

    2018-05-01

    We undertook an analysis of all the reports to the New Zealand Centre for Adverse Reactions Monitoring of a roxithromycin/warfarin interaction after two recent reports described intense rapid warfarin potentiation. The interaction was first published in 1995. Cytochrome P450 3A4 inhibition has been the proposed mechanism but has limited biologic plausibility. There are suggestions that the clinical significance of the interaction may be increased by severe illness, polypharmacy, renal dysfunction, older age and increased warfarin sensitivity. To investigate the potentiating effect of warfarin on roxithromycin in this New Zealand case series, the reports were reviewed to identify patients at risk, compare the reporting pattern with published Australian data and evaluate the appropriateness of current prescribing advice. Thirty patient reports were identified. The age range was 23-88 years, mean 66.8, median 73.0 (standard deviation 17.7) and the international normalised ratios after roxithromycin commencement ranged from 3.6 to 16.7 (mean 7.6, median 7.6, standard deviation 3.6). For eight patients with measurements on day 3, international normalised ratios were 4.3-16.7 (mean 10.4, median 8.8, standard deviation 4.4). Four patients had serious haemorrhage. Indications for roxithromycin were a range of respiratory tract infections. Anticoagulation was stable for most patients prior to acute infection. Serious infection occurred in 54.5% (12 of 22 patients with information). Polypharmacy (five or more medicines daily) was used by 36.7% of patients long term, increasing acutely to 83.3%, including additional potentially interacting medicines. Warfarin daily dose (1.5-13.0 mg, mean 4.4, median 4.0, standard deviation 2.2) was moderate to low. Pre-roxithromycin international normalised ratio values ranged from 1.4 to 3.7, mean and median 2.5, standard deviation 0.5. A high proportion of interactions were observed between warfarin and roxithromycin compared with other

  5. An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas.

    Directory of Open Access Journals (Sweden)

    Priscila Daniele Ramos Cirilo

    Full Text Available Uterine Leiomyomas (ULs are the most common benign tumours affecting women of reproductive age. ULs represent a major problem in public health, as they are the main indication for hysterectomy. Approximately 40-50% of ULs have non-random cytogenetic abnormalities, and half of ULs may have copy number alterations (CNAs. Gene expression microarrays studies have demonstrated that cell proliferation genes act in response to growth factors and steroids. However, only a few genes mapping to CNAs regions were found to be associated with ULs.We applied an integrative analysis using genomic and transcriptomic data to identify the pathways and molecular markers associated with ULs. Fifty-one fresh frozen specimens were evaluated by array CGH (JISTIC and gene expression microarrays (SAM. The CONEXIC algorithm was applied to integrate the data.The integrated analysis identified the top 30 significant genes (P<0.01, which comprised genes associated with cancer, whereas the protein-protein interaction analysis indicated a strong association between FANCA and BRCA1. Functional in silico analysis revealed target molecules for drugs involved in cell proliferation, including FGFR1 and IGFBP5. Transcriptional and protein analyses showed that FGFR1 (P = 0.006 and P<0.01, respectively and IGFBP5 (P = 0.0002 and P = 0.006, respectively were up-regulated in the tumours when compared with the adjacent normal myometrium.The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs.

  6. Sensitivity analysis and parameter estimation for distributed hydrological modeling: potential of variational methods

    Directory of Open Access Journals (Sweden)

    W. Castaings

    2009-04-01

    Full Text Available Variational methods are widely used for the analysis and control of computationally intensive spatially distributed systems. In particular, the adjoint state method enables a very efficient calculation of the derivatives of an objective function (response function to be analysed or cost function to be optimised with respect to model inputs.

    In this contribution, it is shown that the potential of variational methods for distributed catchment scale hydrology should be considered. A distributed flash flood model, coupling kinematic wave overland flow and Green Ampt infiltration, is applied to a small catchment of the Thoré basin and used as a relatively simple (synthetic observations but didactic application case.

    It is shown that forward and adjoint sensitivity analysis provide a local but extensive insight on the relation between the assigned model parameters and the simulated hydrological response. Spatially distributed parameter sensitivities can be obtained for a very modest calculation effort (~6 times the computing time of a single model run and the singular value decomposition (SVD of the Jacobian matrix provides an interesting perspective for the analysis of the rainfall-runoff relation.

    For the estimation of model parameters, adjoint-based derivatives were found exceedingly efficient in driving a bound-constrained quasi-Newton algorithm. The reference parameter set is retrieved independently from the optimization initial condition when the very common dimension reduction strategy (i.e. scalar multipliers is adopted.

    Furthermore, the sensitivity analysis results suggest that most of the variability in this high-dimensional parameter space can be captured with a few orthogonal directions. A parametrization based on the SVD leading singular vectors was found very promising but should be combined with another regularization strategy in order to prevent overfitting.

  7. Potential application of microfocus X-ray techniques for quantitative analysis of bone structure

    International Nuclear Information System (INIS)

    Takahashi, Kenta

    2006-01-01

    With the progress of micro-focused X-ray computed tomography (micro-CT), it has become possible to evaluate the bone structure quantitatively and three-dimensionally. The advantages of micro-CT are that sample preparations are not required and that it provides not only two-dimensional parameters but also three-dimensional stereological indices. This study was carried out to evaluate the potential application of the micro-focus X-ray techniques for quantitative analysis of the new bone produced inside of a hollow chamber of the experimental titanium miniature implant. Twenty-five male wistar rats (9-weeks of age) received experimental titanium miniature implant that had a hollow chamber inside in the left side of the femur. The rats were sacrificed, then the femurs were excised at 4 weeks or 8 weeks after implantation. Micro-CT analysis was performed on the femur samples and the volume of the new bone induced in the hollow chamber of implant was calculated. Percentages of new bone area on the undecalcified histological slides were also measured, linear regression analysis was carried out. In order to evaluate the correlation between pixel numbers of undecalcified slide specimen and pixel numbers of micro-CT image. New bone formation occurred in experimental titanium miniature implant with a hollow chamber. The volume of new bone was measured by micro CT and the area percentage of new bone area against hollow chamber was calculated on the undecalcified slide. Linear regression analysis showed a high correlation between the pixel numbers of undecalcified slide specimen and pixel numbers of micro-CT image. Consequently, the new bone produced inside of the hollow chamber of the experimental titanium miniature implant could be quantified as three-dimensional stereological by micro-CT and its precision was supported by the high correlation between the measurement by micro-CT and conservative two-dimensional measurement of histological slide. (author)

  8. Potential Risk Analysis of Tailings Dam under Preloading Condition and Its Countermeasures

    Directory of Open Access Journals (Sweden)

    Shuren Wang

    2015-01-01

    Full Text Available It is very important for mine production safety to ensure the stability of the tailings dam. Taking a flatland tailings pond as the background, a threedimensional computational model was built based on a tailings dam under mullock heap preloading condition. Considering the current operating water level conditions, a liquid-solid coupling analysis of the model was conducted.The deformation characteristics of the tailings dam were revealed during successive preloading at the front of the dam. The safety factor and the potential slide face of the tailings dam were calculated under different conditions using the strength reduction method. The results show that the tailings dam in its current condition is basically stable, but if the mullock heap continues to be heightened, the tailings dam will become unstable. Therefore, in order to limit the height of the mullock heap, establishing a monitor and early warning mechanism are put forward to ensure mine production safety.

  9. Wavelet analysis as a tool to characteriseand remove environmental noisefrom self-potential time series

    Directory of Open Access Journals (Sweden)

    M. Ragosta

    2004-06-01

    Full Text Available Multiresolution wavelet analysis of self-potential signals and rainfall levels is performed for extracting fluctuations in electrical signals, which might be addressed to meteorological variability. In the time-scale domain of the wavelet transform, rain data are used as markers to single out those wavelet coefficients of the electric signal which can be considered relevant to the environmental disturbance. Then these coefficients are filtered out and the signal is recovered by anti-transforming the retained coefficients. Such methodological approach might be applied to characterise unwanted environmental noise. It also can be considered as a practical technique to remove noise that can hamper the correct assessment and use of electrical techniques for the monitoring of geophysical phenomena.

  10. Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers

    Directory of Open Access Journals (Sweden)

    Jun Ding

    2015-04-01

    Full Text Available Many studies of protein expression after traumatic brain injury (TBI have identified biomarkers for diagnosing or determining the prognosis of TBI. In this study, we searched for additional protein markers of TBI using a fluid perfusion impact device to model TBI in S-D rats. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins. After proteomic analysis, we detected 405 and 371 protein spots within a pH range of 3-10 from sham-treated and contused brain cortex, respectively. Eighty protein spots were differentially expressed in the two groups and 20 of these proteins were identified. This study validated the established biomarkers of TBI and identified potential biomarkers that could be examined in future work.

  11. Computer-assisted sperm morphometry fluorescence-based analysis has potential to determine progeny sex.

    Science.gov (United States)

    Santolaria, Pilar; Pauciullo, Alfredo; Silvestre, Miguel A; Vicente-Fiel, Sandra; Villanova, Leyre; Pinton, Alain; Viruel, Juan; Sales, Ester; Yániz, Jesús L

    2016-01-01

    This study was designed to determine the ability of computer-assisted sperm morphometry analysis (CASA-Morph) with fluorescence to discriminate between spermatozoa carrying different sex chromosomes from the nuclear morphometrics generated and different statistical procedures in the bovine species. The study was divided into two experiments. The first was to study the morphometric differences between X- and Y-chromosome-bearing spermatozoa (SX and SY, respectively). Spermatozoa from eight bulls were processed to assess simultaneously the sex chromosome by FISH and sperm morphometry by fluorescence-based CASA-Morph. SX cells were larger than SY cells on average (P potential to find differences between X- and Y-chromosome-bearing spermatozoa in bovine species although more studies are needed to increase the precision of sex determination by this technique.

  12. World potential of renewable energies actually accessible in the nineties and environmental impacts analysis

    International Nuclear Information System (INIS)

    Dessus, B.; Devin, B.; Pharabod, F.

    1992-01-01

    The role that renewable energies could play in the world's regional and global energy balances gives rise to varied and often quite different evaluations including almost unbounded ones. Reliable information is still available on the different technologies and their economic costs. But, as the commercial development of these renewables is generally very weak, the arguments for postponing their real possible world and regional impact are frequently confused with short term market type considerations. To overcome that difficulty it is proposed to achieve a comprehensive analysis, region by region, of the actually accessible renewable energies at a given horizon. Then we adopt a methodology as the one employed to derive proven renewable energy reserves from energy renewable resources in which resources are defined by quantitative information on physical potential, when reserves take into account technical and economical accessibility

  13. Plutonium analysis from controlled-potential coulometry for the certification of the MP3 standard material

    International Nuclear Information System (INIS)

    Ruas, A.; Dalier, V.; Pivato, J.

    2008-01-01

    Coulometry is an assay method in which the quantity of the element analyzed is determined by measuring a quantity of electricity. For contributing to the certification of the new metal plutonium reference material (MP3), controlled-potential coulometry (CPC) has many advantages: it is a high accuracy absolute chemical analysis technique. Many studies are now conducted on plutonium solutions, to improve the operating conditions and the current apparatus, for mass determination with a precision of 0.1%. The different experimental preliminary results are discussed and the apparatus described. The coulometry cell assembly comprises a motor connected to a stirrer designed to prevent splashing, an inlet tube for inert gas, three electrodes, and a thermocouple for measuring the temperature. The measuring system includes a potentiostat, a CPU, a calibrated current generator, a temperature indicator and a voltmeter, all maintained at a constant temperature. Current integration is made by electronic components, introduced in the potentiostat and the CPU. (authors)

  14. Analysis of potential component cleaning techniques. Final report, July 6, 1992 - July 5, 1995

    International Nuclear Information System (INIS)

    Hess, D.W.

    1997-01-01

    Elevated temperature, elevated pressure water, supercritical carbon dioxide and helical resonator plasmas were investigated for potential use in surface cleaning. A surface analysis system consisting of X-ray Photoelectron Spectroscopy and Auger Electron Spectroscopy was used to evaluate surfaces exposed to water and supercritical carbon dioxide. Langmuir probe and silicon oxidation studies were used to evaluate the effect of oxygen plasmas on silicon surfaces. Silicon oxides were removed from silicon surfaces by water at temperatures above 260 degrees C and pressures above 2000 psi; silicon oxidation and simultaneous dissolution of the oxide grown occurred under these conditions. A new approach for in-situ monitoring of subcritical and supercritical fluid density was devised

  15. Investigation of therapeutic potentials of some selected medicinal plants using neutron activation analysis

    International Nuclear Information System (INIS)

    Abubakar, Sani; Isa, Nasiru Fage; Usman, Ahmed Rufa’i; Khandaker, Mayeen Uddin; Abubakar, Nuraddeen

    2015-01-01

    Series of attempts were made to investigate concentrations of trace elements and their therapeutic properties in various medicinal plants. In this study, samples of some commonly used plants were collected from Bauchi State, Nigeria. They includes leaves of azadirachta indica (neem), Moringa Oleifera (moringa), jatropha curcas (purgin Nut), guiera senegalensis (custard apple) and anogeissus leiocarpus (African birch). These samples were analyzed for their trace elements contents with both short and long irradiation protocols of Instrumental Neutron Activation Analysis (INAA) at Nigerian Research Reactor-1 (NIRR-1) of Ahmadu Bello University, Zaria, Nigeria. The level of trace elements found varies from one sample to another, with some reported at hundreds of mg/Kg dry weight. The results have been compared with the available literature data. The presence of these trace elements indicates promising potentials of these plants for relief of certain ailments

  16. Investigation of therapeutic potentials of some selected medicinal plants using neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Abubakar, Sani; Isa, Nasiru Fage [Bayero University, Kano Nigeria (Nigeria); Usman, Ahmed Rufa’i [University of Malaya, Kuala Lumpur (Malaysia); Umaru Musa Yar’adua University, Katsina Nigeria (Nigeria); Khandaker, Mayeen Uddin [University of Malaya, Kuala Lumpur (Malaysia); Abubakar, Nuraddeen [Center for Energy Research and Training, Ahmadu Bello University, Zaria Nigeria (Nigeria)

    2015-04-24

    Series of attempts were made to investigate concentrations of trace elements and their therapeutic properties in various medicinal plants. In this study, samples of some commonly used plants were collected from Bauchi State, Nigeria. They includes leaves of azadirachta indica (neem), Moringa Oleifera (moringa), jatropha curcas (purgin Nut), guiera senegalensis (custard apple) and anogeissus leiocarpus (African birch). These samples were analyzed for their trace elements contents with both short and long irradiation protocols of Instrumental Neutron Activation Analysis (INAA) at Nigerian Research Reactor-1 (NIRR-1) of Ahmadu Bello University, Zaria, Nigeria. The level of trace elements found varies from one sample to another, with some reported at hundreds of mg/Kg dry weight. The results have been compared with the available literature data. The presence of these trace elements indicates promising potentials of these plants for relief of certain ailments.

  17. Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Grijseels, Sietske; Prigent, Sylvain

    2017-01-01

    Filamentous fungi produce a wide range of bioactive compounds with important pharmaceutical applications, such as antibiotic penicillins and cholesterol-lowering statins. However, less attention has been paid to fungal secondary metabolites compared to those from bacteria. In this study, we...... sequenced the genomes of 9 Penicillium species and, together with 15 published genomes, we investigated the secondary metabolism of Penicillium and identified an immense, unexploited potential for producing secondary metabolites by this genus. A total of 1,317 putative biosynthetic gene clusters (BGCs) were......-referenced the predicted pathways with published data on the production of secondary metabolites and experimentally validated the production of antibiotic yanuthones in Penicillia and identified a previously undescribed compound from the yanuthone pathway. This study is the first genus-wide analysis of the genomic...

  18. Windfall profit in portfolio diversification? An empirical analysis of the potential benefits of renewable energy investments

    Energy Technology Data Exchange (ETDEWEB)

    Bruns, Frederik

    2013-05-01

    Modern Portfolio Theory is a theory which was introduced by Markowitz, and which suggests the building of a portfolio with assets that have low or, in the best case, negative correlation. In times of financial crises, however, the positive diversification effect of a portfolio can fail when Traditional Assets are highly correlated. Therefore, many investors search for Alternative Asset classes, such as Renewable Energies, that tend to perform independently from capital market performance. 'Windfall Profit in Portfolio Diversification?' discusses the potential role of Renewable Energy investments in an institutional investor's portfolio by applying the main concepts from Modern Portfolio Theory. Thereby, the empirical analysis uses a unique data set from one of the largest institutional investors in the field of Renewable Energies, including several wind and solar parks. The study received the Science Award 2012 of the German Alternative Investments Association ('Bundesverband Alternative Investments e.V.').

  19. Analysis of the potential for sustainable, cassava-based bioethanol production in Mali

    DEFF Research Database (Denmark)

    Rasmussen, Kjeld; Bruun, Thilde Bech; Birch-Thomsen, Torben

    and solar resources in Mali 5) Screening of feasible applications of wind and solar energy in Mali: Assessment using the wind and solar maps for Mali The project is being carried out by a group of university departments, research institutions and consultants led by the UNEP Risø Centre (URC......The present project is covered in five main reports: 1) Analyses of the potential for sustainable, cassava-based bio-ethanol production in Mali 2) Agricultural residues for energy production in Mali 3) Pre-feasibility study for an electric power plant based on rice straw 4) Estimation of wind......) at the Technical University of Denmark (DTU) and conducted in cooperation with Direction Nationale de l’Energie (DNE) and Centre National de l’Energie Solaire et des Energies Renouvelables (CNESOLER) in Mali. The subcontracted institutions comprise Geographic Resource Analysis & Science A/S (GRAS), Department...

  20. Investigation of therapeutic potentials of some selected medicinal plants using neutron activation analysis

    Science.gov (United States)

    Abubakar, Sani; Usman, Ahmed Rufa'i.; Isa, Nasiru Fage; Khandaker, Mayeen Uddin; Abubakar, Nuraddeen

    2015-04-01

    Series of attempts were made to investigate concentrations of trace elements and their therapeutic properties in various medicinal plants. In this study, samples of some commonly used plants were collected from Bauchi State, Nigeria. They includes leaves of azadirachta indica (neem), Moringa Oleifera (moringa), jatropha curcas (purgin Nut), guiera senegalensis (custard apple) and anogeissus leiocarpus (African birch). These samples were analyzed for their trace elements contents with both short and long irradiation protocols of Instrumental Neutron Activation Analysis (INAA) at Nigerian Research Reactor-1 (NIRR-1) of Ahmadu Bello University, Zaria, Nigeria. The level of trace elements found varies from one sample to another, with some reported at hundreds of mg/Kg dry weight. The results have been compared with the available literature data. The presence of these trace elements indicates promising potentials of these plants for relief of certain ailments.

  1. Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid

    Directory of Open Access Journals (Sweden)

    Lee Jae-Mok

    2011-07-01

    Full Text Available Abstract Background The inflammatory disease periodontitis results in tooth loss and can even lead to diseases of the whole body if not treated. Gingival crevicular fluid (GCF reflects the condition of the gingiva and contains proteins transuded from serum or cells at inflamed sites. In this study, we aimed to discover potential protein biomarkers for periodontitis in GCF proteome using LC-MS/MS. Results We identified 305 proteins from GCF of healthy individuals and periodontitis patients collected using a sterile gel loading tip by ESI-MS/MS coupled to nano-LC. Among these proteins, about 45 proteins were differentially expressed in the GCF proteome of moderate periodontitis patients when compared to the healthy individuals. We first identified azurocidin in the GCF, but not the saliva, as an upregulated protein in the periodontitis patients and verified its increased expression during periodontitis by ELISA using the GCF of the classified periodontitis patients compared to the healthy individuals. In addition, we found that azurocidin inhibited the differentiation of bone marrow-derived macrophages to osteoclasts. Conclusions Our results show that GCF collection using a gel loading tip and subsequent LC-MS/MS analysis following 1D-PAGE proteomic separation are effective for the analysis of the GCF proteome. Our current results also suggest that azurocidin could be a potential biomarker candidate for the early detection of inflammatory periodontal destruction by gingivitis and some chronic periodontitis. Our data also suggest that azurocidin may have an inhibitory role in osteoclast differentiation and, thus, a protective role in alveolar bone loss during the early stages of periodontitis.

  2. MONITORING POTENTIAL DRUG INTERACTIONS AND REACTIONS VIA NETWORK ANALYSIS OF INSTAGRAM USER TIMELINES.

    Science.gov (United States)

    Correia, Rion Brattig; Li, Lang; Rocha, Luis M

    2016-01-01

    Much recent research aims to identify evidence for Drug-Drug Interactions (DDI) and Adverse Drug reactions (ADR) from the biomedical scientific literature. In addition to this "Bibliome", the universe of social media provides a very promising source of large-scale data that can help identify DDI and ADR in ways that have not been hitherto possible. Given the large number of users, analysis of social media data may be useful to identify under-reported, population-level pathology associated with DDI, thus further contributing to improvements in population health. Moreover, tapping into this data allows us to infer drug interactions with natural products-including cannabis-which constitute an array of DDI very poorly explored by biomedical research thus far. Our goal is to determine the potential of Instagram for public health monitoring and surveillance for DDI, ADR, and behavioral pathology at large. Most social media analysis focuses on Twitter and Facebook, but Instagram is an increasingly important platform, especially among teens, with unrestricted access of public posts, high availability of posts with geolocation coordinates, and images to supplement textual analysis. Using drug, symptom, and natural product dictionaries for identification of the various types of DDI and ADR evidence, we have collected close to 7000 user timelines spanning from October 2010 to June 2015.We report on 1) the development of a monitoring tool to easily observe user-level timelines associated with drug and symptom terms of interest, and 2) population-level behavior via the analysis of co-occurrence networks computed from user timelines at three different scales: monthly, weekly, and daily occurrences. Analysis of these networks further reveals 3) drug and symptom direct and indirect associations with greater support in user timelines, as well as 4) clusters of symptoms and drugs revealed by the collective behavior of the observed population. This demonstrates that Instagram

  3. MONITORING POTENTIAL DRUG INTERACTIONS AND REACTIONS VIA NETWORK ANALYSIS OF INSTAGRAM USER TIMELINES

    Science.gov (United States)

    CORREIA, RION BRATTIG; LI, LANG; ROCHA, LUIS M.

    2015-01-01

    Much recent research aims to identify evidence for Drug-Drug Interactions (DDI) and Adverse Drug reactions (ADR) from the biomedical scientific literature. In addition to this “Bibliome”, the universe of social media provides a very promising source of large-scale data that can help identify DDI and ADR in ways that have not been hitherto possible. Given the large number of users, analysis of social media data may be useful to identify under-reported, population-level pathology associated with DDI, thus further contributing to improvements in population health. Moreover, tapping into this data allows us to infer drug interactions with natural products—including cannabis—which constitute an array of DDI very poorly explored by biomedical research thus far. Our goal is to determine the potential of Instagram for public health monitoring and surveillance for DDI, ADR, and behavioral pathology at large. Most social media analysis focuses on Twitter and Facebook, but Instagram is an increasingly important platform, especially among teens, with unrestricted access of public posts, high availability of posts with geolocation coordinates, and images to supplement textual analysis. Using drug, symptom, and natural product dictionaries for identification of the various types of DDI and ADR evidence, we have collected close to 7000 user timelines spanning from October 2010 to June 2015. We report on 1) the development of a monitoring tool to easily observe user-level timelines associated with drug and symptom terms of interest, and 2) population-level behavior via the analysis of co-occurrence networks computed from user timelines at three different scales: monthly, weekly, and daily occurrences. Analysis of these networks further reveals 3) drug and symptom direct and indirect associations with greater support in user timelines, as well as 4) clusters of symptoms and drugs revealed by the collective behavior of the observed population. This demonstrates that

  4. Design and development of a phantom for tomosynthesis with potential for automated analysis via the cloud.

    Science.gov (United States)

    Goodenough, David; Levy, Josh; Olafsdottir, Hildur; Olafsson, Ingvi

    2018-03-06

    This paper describes Development of a Phantom for Tomosynthesis with Potential for Automated Analysis via the Cloud. Several studies are underway to investigate the effectiveness of Tomosynthesis Mammographic Image Screening, including the large TMIST project as funded by the National Cancer Institute https://www.cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/tmist. The development of the phantom described in this paper follows initiatives from the FDA, the AAPM TG245 task group, and European Reference Organization (EUREF) for Quality Assured Breast Screening and Diagnostic Services Committee report noting, that no formal endorsement nor recommendation for use has been sought, or granted by any of these groups. This paper reports on the possibility of using this newly developed Tomosynthesis Phantom for Quality Assurance, field testing of image performance, including remote monitoring of DBT system performance, e.g., via transmission over the cloud. The phantom includes tests for: phantom positioning and alignment (important for remote analysis), scan geometry (x and y), chest wall offset, scan slice width and Slice Sensitivity Profile (SSP(z)) slice geometry (slice width), scan slice incrementation (z), z axis geometry bead, low contrast detectability using low contrast spheres, spatial resolution via Point Spread Function (PSF), Image uniformity, Signal to Noise Ratio (SNR), and Contrast to Noise Ratio (CNR) via readings over an Aluminum square. The phantom is designed for use with automated analysis via transmission of images over the cloud and the analysis package includes test of positioning accuracy (roll, pitch, and yaw). Data are shown from several commercial Tomosynthesis Scanners including Fuji, GE, Hologic, IMS-Giotti, and Siemens; however, the focus of this paper is on phantom design, and not in general aimed at direct commercial comparisons, and wherever possible the identity of the data is anonymized. Results of automated analysis of

  5. Alternative future analysis for assessing the potential impact of climate change on urban landscape dynamics.

    Science.gov (United States)

    He, Chunyang; Zhao, Yuanyuan; Huang, Qingxu; Zhang, Qiaofeng; Zhang, Da

    2015-11-01

    Assessing the impact of climate change on urban landscape dynamics (ULD) is the foundation for adapting to climate change and maintaining urban landscape sustainability. This paper demonstrates an alternative future analysis by coupling a system dynamics (SD) and a cellular automata (CA) model. The potential impact of different climate change scenarios on ULD from 2009 to 2030 was simulated and evaluated in the Beijing-Tianjin-Tangshan megalopolis cluster area (BTT-MCA). The results suggested that the integrated model, which combines the advantages of the SD and CA model, has the strengths of spatial quantification and flexibility. Meanwhile, the results showed that the influence of climate change would become more severe over time. In 2030, the potential urban area affected by climate change will be 343.60-1260.66 km(2) (5.55 -20.37 % of the total urban area, projected by the no-climate-change-effect scenario). Therefore, the effects of climate change should not be neglected when designing and managing urban landscape. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Testing and injury potential analysis of rollovers with narrow object impacts.

    Science.gov (United States)

    Meyer, Steven E; Forrest, Stephen; Herbst, Brian; Hayden, Joshua; Orton, Tia; Sances, Anthony; Kumaresan, Srirangam

    2004-01-01

    Recent statistics highlight the significant risk of serious and fatal injuries to occupants involved in rollover collisions due to excessive roof crush. The government has reported that in 2002. Sports Utility Vehicle rollover related fatalities increased by 14% to more than 2400 annually. 61% of all SUV fatalities included rollovers [1]. Rollover crashes rely primarily upon the roof structures to maintain occupant survival space. Frequently these crashes occur off the travel lanes of the roadway and, therefore, can include impacts with various types of narrow objects such as light poles, utility poles and/or trees. A test device and methodology is presented which facilitates dynamic, repeatable rollover impact evaluation of complete vehicle roof structures with such narrow objects. These tests allow for the incorporation of Anthropomorphic Test Dummies (ATDs) which can be instrumented to measure accelerations, forces and moments to evaluate injury potential. High-speed video permits for detailed analysis of occupant kinematics and evaluation of injury causation. Criteria such as restraint performance, injury potential, survival space and the effect of roof crush associated with various types of design alternatives, countermeasures and impact circumstances can also be evaluated. In addition to presentation of the methodology, two representative vehicle crash tests are also reported. Results indicated that the reinforced roof structure significantly reduced the roof deformation compared to the production roof structure.

  7. Comparative genomic analysis of Lactobacillus plantarum ZJ316 reveals its genetic adaptation and potential probiotic profiles.

    Science.gov (United States)

    Li, Ping; Li, Xuan; Gu, Qing; Lou, Xiu-Yu; Zhang, Xiao-Mei; Song, Da-Feng; Zhang, Chen

    2016-08-01

    In previous studies, Lactobacillus plantarum ZJ316 showed probiotic properties, such as antimicrobial activity against various pathogens and the capacity to significantly improve pig growth and pork quality. The purpose of this study was to reveal the genes potentially related to its genetic adaptation and probiotic profiles based on comparative genomic analysis. The genome sequence of L. plantarum ZJ316 was compared with those of eight L. plantarum strains deposited in GenBank. BLASTN, Mauve, and MUMmer programs were used for genome alignment and comparison. CRISPRFinder was applied for searching the clustered regularly interspaced short palindromic repeats (CRISPRs). We identified genes that encode proteins related to genetic adaptation and probiotic profiles, including carbohydrate transport and metabolism, proteolytic enzyme systems and amino acid biosynthesis, CRISPR adaptive immunity, stress responses, bile salt resistance, ability to adhere to the host intestinal wall, exopolysaccharide (EPS) biosynthesis, and bacteriocin biosynthesis. Comparative characterization of the L. plantarum ZJ316 genome provided the genetic basis for further elucidating the functional mechanisms of its probiotic properties. ZJ316 could be considered a potential probiotic candidate.

  8. Comparative genomic analysis of Lactobacillus plantarum ZJ316 reveals its genetic adaptation and potential probiotic profiles* #

    Science.gov (United States)

    Li, Ping; Li, Xuan; Gu, Qing; Lou, Xiu-yu; Zhang, Xiao-mei; Song, Da-feng; Zhang, Chen

    2016-01-01

    Objective: In previous studies, Lactobacillus plantarum ZJ316 showed probiotic properties, such as antimicrobial activity against various pathogens and the capacity to significantly improve pig growth and pork quality. The purpose of this study was to reveal the genes potentially related to its genetic adaptation and probiotic profiles based on comparative genomic analysis. Methods: The genome sequence of L. plantarum ZJ316 was compared with those of eight L. plantarum strains deposited in GenBank. BLASTN, Mauve, and MUMmer programs were used for genome alignment and comparison. CRISPRFinder was applied for searching the clustered regularly interspaced short palindromic repeats (CRISPRs). Results: We identified genes that encode proteins related to genetic adaptation and probiotic profiles, including carbohydrate transport and metabolism, proteolytic enzyme systems and amino acid biosynthesis, CRISPR adaptive immunity, stress responses, bile salt resistance, ability to adhere to the host intestinal wall, exopolysaccharide (EPS) biosynthesis, and bacteriocin biosynthesis. Conclusions: Comparative characterization of the L. plantarum ZJ316 genome provided the genetic basis for further elucidating the functional mechanisms of its probiotic properties. ZJ316 could be considered a potential probiotic candidate. PMID:27487802

  9. Free radical scavenging potential and HPTLC analysis of Indigofera tinctoria linn (Fabaceae

    Directory of Open Access Journals (Sweden)

    Sakthivel Srinivasan

    2016-04-01

    Full Text Available The objective of this study was to evaluate the free radical scavenging potential and high performance thin layer chromatography (HPTLC fingerprinting of Indigofera tinctoria (I. tinctoria. Phytochemical analysis was carried out using standard methods, and free radical scavenging activity of the plant was determined using 2,2-diphenyl-1-picrylhydrazy (DPPH, nitric oxide (NO and superoxide anion (O2− radical scavenging capacities. HPTLC plate was kept in CAMAG TLC Scanner 3 and the Rf values at fingerprint data were recorded by WINCATS software. Aqueous extract of I. tinctoria reliably showed the total phenolics (267.2±2.42 mg/g, flavonoids (75.43±3.36 mg/g and antioxidants (349.11±8.04 mg/g. The extract was found to have DPPH (52.08%, NO (23.12% and O2− (26.79% scavenging activities at the concentration of 250 μg/mL and the results were statistically significant compared with ascorbic acid standard (p<0.05. HPTLC results confirmed that the extract contained several potential active components such as phenols, flavonoids, saponins and terpenoids as the slides revealed multi-colored bands of varying intensities. This study confirmed that the plant had multipotential antioxidant and free radicals scavenging activities.

  10. An analysis of potential costs of adverse events based on Drug Programs in Poland. Pulmonology focus

    Directory of Open Access Journals (Sweden)

    Szkultecka-Debek Monika

    2014-06-01

    Full Text Available The project was performed within the Polish Society for Pharmacoeconomics (PTFE. The objective was to estimate the potential costs of treatment of side effects, which theoretically may occur as a result of treatment of selected diseases. We analyzed the Drug Programs financed by National Health Fund in Poland in 2012 and for the first analysis we selected those Programs where the same medicinal products were used. We based the adverse events selection on the Summary of Product Characteristics of the chosen products. We extracted all the potential adverse events defined as frequent and very frequent, grouping them according to therapeutic areas. This paper is related to the results in the pulmonology area. The events described as very common had an incidence of ≥ 1/10, and the common ones ≥ 1/100, <1/10. In order to identify the resources used, we performed a survey with the engagement of clinical experts. On the basis of the collected data we allocated direct costs incurred by the public payer. We used the costs valid in December 2013. The paper presents the estimated costs of treatment of side effects related to the pulmonology disease area. Taking into account the costs incurred by the NHF and the patient separately e calculated the total spending and the percentage of each component cost in detail. The treatment of adverse drug reactions generates a significant cost incurred by both the public payer and the patient.

  11. Analysis on uranium mineralization-formation condition and prospecting potential in Xidamingshan metallogenic belt

    International Nuclear Information System (INIS)

    Li Zhixing; Qi Fucheng; He Zhongbo; Zhang Zilong

    2012-01-01

    There are many different opinions about the source of uranium and metallogenic mechanism in Xidamingshan metallogenic belt. therefore it blocked uranium resources potential evaluation and ore exploration. Through absorb in- formation and investigate Daxin deposit and systematic analysis on samples. It is believed that uranium source mainly came from Cambrian System, a little came from the deep. The Devonian System is favorable room for saving ores in addition to be pre-concentrated room for uranium. Also, there are new cognition about uranium metallogenic mechanism, establish ore-forming series of Xidamingshan metallogenic belt, It is proposed that uranium mineralization have experienced 4 stages; It is cleared that hydrothermal fluid superposition transform type uranium deposit is main genetic type, ancient karst accumulate type is secondary genetic type, the later is formed by leaching the former and then precipitate, enrichment in ancient karst congeries, which is formed nearby faults and with the movement of Xishan structural movement. It is proven that metallogenic potential of Xidamingshan metallogenic belt is good. Tectonic rock controlled by subsidiary fracture nearby regional main fault, which connected with the Cambrian System and the Devonian System, and the deep of the deposit is guideline of mineral prospecting next stage. (authors)

  12. Analysis on energy saving potential of integrated supermarket HVAC and refrigeration systems using multiple subcoolers

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Liang [Institute of Refrigeration and Cryogenics, Shanghai Jiaotong University, Shanghai 200240 (China); China R and D Center, Carrier Corporation, No. 3239 Shen Jiang Road, Shanghai 201206 (China); Zhang, Chun-Lu [China R and D Center, Carrier Corporation, No. 3239 Shen Jiang Road, Shanghai 201206 (China)

    2010-02-15

    The paper presents a model-based analysis on the energy saving potential of supermarket HVAC (heating, ventilating, and air-conditioning) and refrigeration systems using multiple subcoolers among the high-temperature HVAC system, the medium-temperature refrigeration system, and the low-temperature refrigeration system. The principle of energy reduction is to have the higher COP (coefficient of performance) system generate more cooling capacity to increase the cooling capacity or reduce the power consumption of the lower COP system. The subcooler could be placed between the medium-temperature and low-temperature systems, between the high-temperature and medium-temperature systems, and between the high-temperature and low-temperature systems. All integration scenarios of adding one, two and three subcoolers have been investigated. The energy saving potential varies with the load ratio between high-, medium- and low-temperature systems, COP of three systems, and the ''on-off'' duty time of HVAC system. The optimal sequence of adding subcoolers is also proposed. (author)

  13. A computational perspective of vibrational and electronic analysis of potential photosensitizer 2-chlorothioxanthone

    Science.gov (United States)

    Ali, Narmeen; Mansha, Asim; Asim, Sadia; Zahoor, Ameer Fawad; Ghafoor, Sidra; Akbar, Muhammad Usman

    2018-03-01

    This paper deals with combined theoretical and experimental study of geometric, electronic and vibrational properties of 2-chlorothioxanthone (CTX) molecule which is potential photosensitizer. The FT-IR spectrum of CTX in solid phase was recorded in 4000-400 cm-1 region. The UV-Vis. absorption spectrum was also recorded in the laboratory as well as computed at DFT/B3LYP level in five different phases viz. gas, water, DMSO, acetone and ethanol. The quantum mechanics based theoretical IR and Raman spectra were also calculated for the title compound employing HF and DFT functional with 3-21G+, 6-31G+ and 6-311G+, 6-311G++ basis sets, respectively, and assignment of each vibrational frequency has been done on the basis of potential energy distribution (PED). A comparison has been made between theoretical and experimental vibrational spectra as well as for the UV-Vis. absorption spectra. The computed infra red & Raman spectra by DFT compared with experimental spectra along with reliable vibrational assignment based on PED. The calculated electronic properties, results of natural bonding orbital (NBO) analysis, charge distribution, dipole moment and energies have been reported in the paper. Bimolecular quenching of triplet state of CTX in the presence of triethylamine, 2-propanol triethylamine and diazobicyclooctane (DABCO) reflect the interactions between them. The bimolecular quenching rate constant is fastest for interaction of 3CTX in the presence of DABCO reflecting their stronger interactions.

  14. Analysis of the proliferative potential of odontogenic epithelial cells of pericoronal follicles.

    Science.gov (United States)

    Cimadon, Natalia; Lauxen, Isabel Silva; Carrard, Vinicius Coelho; Sant'Ana Filho, Manoel; Rados, Pantelis Varvaki; Oliveira, Márcia Gaiger

    2014-11-01

    To evaluate the proliferative potential and the cell proliferation rate of odontogenic epithelial cells. Forty-two cases of pericoronal follicles of impacted third molars were submitted to silver impregnation technique for quantification of argyrophilic nucleolar organizer regions (AgNOR) and immunohistochemical staining for EGFR and Ki-67. For AgNOR quantification, the mean number of active nucleolar organizer regions per nucleus (mAgNOR) and the percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were quantified. Ki-67 immunolabeling was quantified, whereas for EGFR, a descriptive analysis of staining patterns (membrane, cytoplasm or membrane + cytoplasm positivity) was performed. We evaluated the reduced epithelium of the enamel organ and/or islands of odontogenic epithelium present in the entire connective tissue. mAgNOR were 1.43 (1.0-2.42) and were significantly different among pericoronary follicles from upper and lower teeth (p = 0.041). Immunostaining of Ki-67 was negative in all cases. EGFR immunolabeling was found mainly in the cytoplasm and was more intense in islands and cords when compared to reduced epithelium of the enamel organ. Odontogenic epithelial cells of some pericoronal follicles have proliferative potential, suggesting their association with the development of odontogenic lesions. The authors suggest that nonerupted, especially of the lower teeth, should be monitored and if necessary removed.

  15. Perturbation analysis of spontaneous action potential initiation by stochastic ion channels

    KAUST Repository

    Keener, James P.; Newby, Jay M.

    2011-01-01

    A stochastic interpretation of spontaneous action potential initiation is developed for the Morris-Lecar equations. Initiation of a spontaneous action potential can be interpreted as the escape from one of the wells of a double well potential

  16. Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis.

    Science.gov (United States)

    Conraths, Franz J; Probst, Carolina; Possenti, Alessia; Boufana, Belgees; Saulle, Rosella; La Torre, Giuseppe; Busani, Luca; Casulli, Adriano

    2017-07-01

    Human alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of Echinococcus multilocularis. AE is commonly associated with a long incubation period that may last for more than ten years. The objective of this systematic literature review was to identify and summarize the current knowledge on statistically relevant potential risk factors (PRFs) associated with AE in humans. Six bibliographic databases were searched, generating a total of 1,009 publications. Following the removal of duplicate records and the exclusion of papers that failed to meet the criteria of a previously agreed a priori protocol, 23 publications were retained; however, 6 of these did not contain data in a format that allowed their inclusion in the meta-analysis. The remaining 17 publications (6 case-control and 11 cross-sectional studies) were meta-analysed to investigate associations between AE and PRFs. Pooled odds ratios (OR) were used as a measure of effect and separately analysed for case-control and cross-sectional studies. In the case-control studies, the following PRFs for human AE showed higher odds of outcome: "dog ownership", "cat ownership", "have a kitchen garden", "occupation: farmer", "haymaking in meadows not adjacent to water", "went to forests for vocational reasons", "chewed grass" and "hunting / handling foxes". In the cross-sectional studies, the following PRFs showed higher odds of outcome: "dog ownership", "play with dogs", "gender: female", "age over 20 years", "ethnic group: Tibetan", "low income", "source of drinking water other than well or tap", "occupation: herding" and "low education". Our meta-analysis confirmed that the chance of AE transmission through ingestion of food and water contaminated with E. multilocularis eggs exists, but showed also that food- and water-borne PRFs do not significantly increase the risk of infection. This systematic review analysed international peer-reviewed articles that have over the years

  17. Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Franz J Conraths

    2017-07-01

    Full Text Available Human alveolar echinococcosis (AE is a severe zoonotic disease caused by the metacestode stage of Echinococcus multilocularis. AE is commonly associated with a long incubation period that may last for more than ten years. The objective of this systematic literature review was to identify and summarize the current knowledge on statistically relevant potential risk factors (PRFs associated with AE in humans.Six bibliographic databases were searched, generating a total of 1,009 publications. Following the removal of duplicate records and the exclusion of papers that failed to meet the criteria of a previously agreed a priori protocol, 23 publications were retained; however, 6 of these did not contain data in a format that allowed their inclusion in the meta-analysis. The remaining 17 publications (6 case-control and 11 cross-sectional studies were meta-analysed to investigate associations between AE and PRFs. Pooled odds ratios (OR were used as a measure of effect and separately analysed for case-control and cross-sectional studies. In the case-control studies, the following PRFs for human AE showed higher odds of outcome: "dog ownership", "cat ownership", "have a kitchen garden", "occupation: farmer", "haymaking in meadows not adjacent to water", "went to forests for vocational reasons", "chewed grass" and "hunting / handling foxes". In the cross-sectional studies, the following PRFs showed higher odds of outcome: "dog ownership", "play with dogs", "gender: female", "age over 20 years", "ethnic group: Tibetan", "low income", "source of drinking water other than well or tap", "occupation: herding" and "low education". Our meta-analysis confirmed that the chance of AE transmission through ingestion of food and water contaminated with E. multilocularis eggs exists, but showed also that food- and water-borne PRFs do not significantly increase the risk of infection.This systematic review analysed international peer-reviewed articles that have over the

  18. Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies.

    Directory of Open Access Journals (Sweden)

    Hongwei Chu

    Full Text Available Epilepsy is a complex neurological disorder and a significant health problem. The pathogenesis of epilepsy remains obscure in a significant number of patients and the current treatment options are not adequate in about a third of individuals which were known as refractory epilepsies (RE. Network medicine provides an effective approach for studying the molecular mechanisms underlying complex diseases. Here we integrated 1876 disease-gene associations of RE and located those genes to human protein-protein interaction (PPI network to obtain 42 significant RE-associated disease modules. The functional analysis of these disease modules showed novel molecular pathological mechanisms of RE, such as the novel enriched pathways (e.g., "presynaptic nicotinic acetylcholine receptors", "signaling by insulin receptor". Further analysis on the relationships between current drug targets and the RE-related disease genes showed the rational mechanisms of most antiepileptic drugs. In addition, we detected ten potential novel drug targets (e.g., KCNA1, KCNA4-6, KCNC3, KCND2, KCNMA1, CAMK2G, CACNB4 and GRM1 located in three RE related disease modules, which might provide novel insights into the new drug discovery for RE therapy.

  19. Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue

    Directory of Open Access Journals (Sweden)

    Sudheer Gupta

    2018-04-01

    Full Text Available The pathogenesis of dengue hemorrhagic fever (DHF, following dengue virus (DENV infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF. Our analysis considered the development of DHF in three different perspectives: (a as a consequence of primary DENV infection, (b following secondary DENV infection with a heterologous serotype, (c as a result of DENV infection following infection with related flaviviruses like Zika virus, Japanese Encephalitis virus, West Nile virus, etc. Subject to experimental validation, these viral and host markers would be valuable in triaging DENV-infected patients for closer supervision owing to the relatively higher risk of poor prognostic outcome and also for the judicious allocation of scarce institutional resources during large outbreaks.

  20. Sedation for pediatric radiological procedures: analysis of potential causes of sedation failure and paradoxical reactions

    Energy Technology Data Exchange (ETDEWEB)

    Karian, V.E.; Burrows, P.E.; Connor, L. [Dept. of Radiology, Children' s Hospital, Boston, MA (United States); Zurakowski, D. [Dept. of Biostatistics, Children' s Hospital, Boston, MA (United States); Mason, K.P. [Dept. of Anesthesiology, Children' s Hospital, Boston, MA (United States)

    1999-11-01

    Background. Sedation for diagnostic imaging and interventional radiologic procedures in pediatrics has greatly increased over the past decade. With appropriate patient selection and monitoring, serious adverse effects are infrequent, but failure to sedate and paradoxical reactions do occur. Objective. The purpose of this study was to determine, among patients undergoing sedation for radiologic procedures, the incidence of sedation failure and paradoxical reaction to pentobarbital and to identify potentially correctable causes. Materials and methods. Records of 1665 patients who were sedated in the radiology department from 1 November 1997 to 1 July 1998 were reviewed. Patients failing sedation or experiencing paradoxical reaction were compared with respect to sex, age group, diagnosis, scan type, time of day, NPO status, use of IV contrast and type of sedation agent using the Fisher exact test, Pearson chi-square, analysis of variance (ANOVA), the Student t-test, and logistic regression. Results. Data analysis revealed a sedation failure rate of 1 % and paradoxical reaction rate of 1.2 %. Stepwise multiple logistic regression revealed that the only significant independent multivariate predictor of failure was the need for the administration of a combination of pentobarbital, fentanyl, and midazolam IV. Conclusion. The low rate of sedation failure and paradoxical reactions to pentobarbital was near optimal and probably cannot be improved with the currently available sedatives. (orig.)

  1. Sedation for pediatric radiological procedures: analysis of potential causes of sedation failure and paradoxical reactions

    International Nuclear Information System (INIS)

    Karian, V.E.; Burrows, P.E.; Connor, L.; Zurakowski, D.; Mason, K.P.

    1999-01-01

    Background. Sedation for diagnostic imaging and interventional radiologic procedures in pediatrics has greatly increased over the past decade. With appropriate patient selection and monitoring, serious adverse effects are infrequent, but failure to sedate and paradoxical reactions do occur. Objective. The purpose of this study was to determine, among patients undergoing sedation for radiologic procedures, the incidence of sedation failure and paradoxical reaction to pentobarbital and to identify potentially correctable causes. Materials and methods. Records of 1665 patients who were sedated in the radiology department from 1 November 1997 to 1 July 1998 were reviewed. Patients failing sedation or experiencing paradoxical reaction were compared with respect to sex, age group, diagnosis, scan type, time of day, NPO status, use of IV contrast and type of sedation agent using the Fisher exact test, Pearson chi-square, analysis of variance (ANOVA), the Student t-test, and logistic regression. Results. Data analysis revealed a sedation failure rate of 1 % and paradoxical reaction rate of 1.2 %. Stepwise multiple logistic regression revealed that the only significant independent multivariate predictor of failure was the need for the administration of a combination of pentobarbital, fentanyl, and midazolam IV. Conclusion. The low rate of sedation failure and paradoxical reactions to pentobarbital was near optimal and probably cannot be improved with the currently available sedatives. (orig.)

  2. Analysis of potential radiation-induced genetic and somatic effects to man from milling of uranium

    International Nuclear Information System (INIS)

    Momeni, M.H.

    1984-01-01

    Potential mortality from natural causes and from radiation exposure conditions typical of those in the vicinity of uranium mills in the western USA was calculated. The exposure conditions were those assumed to exist in the vicinity of a hypothetical model mill. Dose rates to organs at risk were calculated as a function of time using the Uranium Dispersion and Dosimetry Code (Momeni et al. 1979). The changes in population size, birth rates, and radiation-induced and natural mortalities were calculated using the PRIM code (Momeni 1983). The population of the region within a radius of 80 km from the model mill is projected to increase from 57 428 to 75 638.6 during the 85 years of this analysis. Within the same period, the average birth rates for five-year periods increase from 5067.8 to 7436.1. The cumulative deaths within the five-year periods increase from 724 and 3501.8 from spontaneously induced neoplasms and all causes, respectively, to 1538.2 and 6718.2. In comparison to natural causes, radiation-induced mortality is negligible. The highest rate of death from radiation in any five-year period is only 0.2, compared with 1538.2 deaths attributable to spontaneous incidence. The total radiation-induced genetic disorders were much less than unity for the 85-year period of analysis, in contrast with the 10.7% natural incidence of these disorders

  3. Potential of PIXE for the elemental analysis of calcium hydroxide used in dentistry

    International Nuclear Information System (INIS)

    Suciu, Ioana; Ionescu, Ecaterina; Bodnar, Dan; Preoteasa, Eugen A.; Gurban, Dan

    2006-01-01

    Calcium hydroxide is used in dentistry and generally shows a clinically acceptable biocompatibility. However various commercial assortments show differences in their clinical performances, suggesting that certain aspects of their action are not completely understood and pointing to the necessity of new investigation methods. We report a preliminary study on two types of calcium hydroxide products carried out by thick target PIXE with 3.0 MeV protons, aiming to assess the potential of this method for the analysis of such biomaterials used in endodontic dentistry. (Semi)quantitative analysis was performed by use of reference materials, and relative concentrations of elements with respect to Ca were determined with an accuracy of about 30%; tentative absolute concentrations were also estimated by using Ca as a reference element. In both formulations, a number of trace elements (Mn, Fe, Zn and Sr, and possibly Cu and Pb - probably impurities from the raw materials) were evidenced. These trace elements together with the Ba/Ca ratio are reliable fingerprints for the identification of the materials, and evidenced a different origin for the Ca(OH) 2 used in the two specimens. Possible applications of PIXE in dental research may bring relevant compositional insight, and further studies of such materials are suggested. (authors)

  4. Proteomic analysis of PBMCs: characterization of potential HIV-associated proteins

    Directory of Open Access Journals (Sweden)

    Yin Lin

    2010-03-01

    Full Text Available Abstract Background The human immunodeficiency virus type 1 (HIV-1 pandemic has continued unabated for nearly 30 years. To better understand the influence of virus on host cells, we performed the differential proteome research of peripheral blood mononuclear cells (PBMCs from HIV-positive patients and healthy controls. Results 26 protein spots with more than 1.5-fold difference were detected in two dimensional electrophoresis (2DE gels. 12 unique up-regulated and one down-regulated proteins were identified in HIV-positive patients compared with healthy donors. The mRNA expression of 10 genes was analyzed by real time RT-PCR. It shows that the mRNA expression of talin-1, vinculin and coronin-1C were up-regulated in HIV positive patients and consistent with protein expression. Western blotting analysis confirmed the induction of fragments of vinculin, talin-1 and filamin-A in pooled and most part of individual HIV-positive clinical samples. Bioinformatic analysis showed that a wide host protein network was disrupted in HIV-positive patients. Conclusions Together, this work provided useful information to facilitate further investigation of the underlying mechanism of HIV and host cell protein interactions, and discovered novel potential biomarkers such as fragment of vinculin, filamin-A and talin-1 for anti-HIV research.

  5. Bivariable analysis of ventricular late potentials in high resolution ECG records

    International Nuclear Information System (INIS)

    Orosco, L; Laciar, E

    2007-01-01

    In this study the bivariable analysis for ventricular late potentials detection in high-resolution electrocardiographic records is proposed. The standard time-domain analysis and the application of the time-frequency technique to high-resolution ECG records are briefly described as well as their corresponding results. In the proposed technique the time-domain parameter, QRSD and the most significant time-frequency index, EN QRS are used like variables. A bivariable index is defined, that combines the previous parameters. The propose technique allows evaluating the risk of ventricular tachycardia in post-myocardial infarct patients. The results show that the used bivariable index allows discriminating between the patient's population with ventricular tachycardia and the subjects of the control group. Also, it was found that the bivariable technique obtains a good valuation as diagnostic test. It is concluded that comparatively, the valuation of the bivariable technique as diagnostic test is superior to that of the time-domain method and the time-frequency technique evaluated individually

  6. Advantages and limitations of potential methods for the analysis of bacteria in milk: a review.

    Science.gov (United States)

    Tabit, Frederick Tawi

    2016-01-01

    Contamination concerns in the dairy industry are motivated by outbreaks of disease in humans and the inability of thermal processes to eliminate bacteria completely in processed products. HACCP principles are an important tool used in the food industry to identify and control potential food safety hazards in order to meet customer demands and regulatory requirements. Milk testing is of importance to the milk industry regarding quality assurance and monitoring of processed products by researchers, manufacturers and regulatory agencies. Due to the availability of numerous methods used for analysing the microbial quality of milk in literature and differences in priorities of stakeholders, it is sometimes confusing to choose an appropriate method for a particular analysis. The objective of this paper is to review the advantages and disadvantages of selected techniques that can be used in the analysis of bacteria in milk. SSC, HRMA, REP, and RAPD are the top four techniques which are quick and cost-effective and possess adequate discriminatory power for the detection and profiling of bacteria. The following conclusions were arrived at during this review: HRMA, REP and RFLP are the techniques with the most reproducible results, and the techniques with the most discriminatory power are AFLP, PFGE and Raman Spectroscopy.

  7. Evaluation of an automated analysis for pain-related evoked potentials

    Directory of Open Access Journals (Sweden)

    Wulf Michael

    2017-09-01

    Full Text Available This paper presents initial steps towards an auto-mated analysis for pain-related evoked potentials (PREP to achieve a higher objectivity and non-biased examination as well as a reduction in the time expended during clinical daily routines. While manually examining, each epoch of an en-semble of stimulus-locked EEG signals, elicited by electrical stimulation of predominantly intra-epidermal small nerve fibers and recorded over the central electrode (Cz, is in-spected for artifacts before calculating the PREP by averag-ing the artifact-free epochs. Afterwards, specific peak-latencies (like the P0-, N1 and P1-latency are identified as certain extrema in the PREP’s waveform. The proposed automated analysis uses Pearson’s correlation and low-pass differentiation to perform these tasks. To evaluate the auto-mated analysis’ accuracy its results of 232 datasets were compared to the results of the manually performed examina-tion. Results of the automated artifact rejection were compa-rable to the manual examination. Detection of peak-latencies was more heterogeneous, indicating some sensitivity of the detected events upon the criteria used during data examina-tion.

  8. Potential effects of ocean acidification on Alaskan corals based on calcium carbonate mineralogy composition analysis (NCEI Accession 0157223)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains potential effects of ocean acidification on Alaskan corals based on calcium carbonate mineralogy composition analysis. Effects of...

  9. Analysis of winter weather conditions and their potential impact on wind farm operations

    Science.gov (United States)

    Novakovskaia, E.; Treinish, L. A.; Praino, A.

    2009-12-01

    Severe weather conditions have two primary impacts on wind farm operations. The first relates to understanding potential damage to the turbines themselves and what actions are required to mitigate the effects. The second is recognizing what conditions may lead to a full or partial shutdown of the wind farm with sufficient lead time to determine the likely inability to meet energy generation committments. Ideally, wind forecasting suitable for wind farm operations should be of sufficient fidelity to resolve features within the boundary layer that lead to either damaging conditions or useful power generation. Given the complexity of the site-specific factors that effect the boundary layer at the scale of typical land-based wind farm locations such as topography, vegetation, land use, soil conditions, etc., which may vary with turbine design and layout within the farm, enabling reliable forecasts of too little or too much wind is challenging. A potential solution should involve continuous updates of alert triggering criteria through analysis of local wind patterns and probabilistic risk assessment for each location. To evaluate this idea, we utilize our operational mesoscale prediction system, dubbed “Deep Thunder”, developed at the IBM Thomas J. Watson Research Center. In particular, we analyze winter-time near-surface winds in upstate New York, where four similar winds farms are located. Each of these farms were built at roughly the same time and utilize similar turbines. Given the relative uncertainty associated with numerical weather prediction at this scale, and the difference in risk assessment due to the two primary impacts of severe weather, probabilistic forecasts are a prerequisite. Hence, we have employed ensembles of weather scenarios, which are based on the NCAR WRF-ARW modelling system. The set of ensemble members was composed with variations in the choices of physics and parameterization schemes, and source of background fields for initial

  10. Bioinformatic Analysis of Potential Biomarkers for Spinal Cord Injured Patients With Intractable Neuropathic Pain.

    Science.gov (United States)

    Wang, Yimin; Ye, Fang; Huang, Chanyan; Xue, Faling; Li, Yingyuan; Gao, Shaowei; Qiu, Zeting; Li, Si; Chen, Qinchang; Zhou, Huaqiang; Song, Yiyan; Huang, Wenqi; Tan, Wulin; Wang, Zhongxing

    2018-03-15

    Neuropathic pain is one of the common complications after spinal cord injury (SCI), affecting patients' life quality. The molecular mechanism for neuropathic pain after SCI is still unclear. We aimed to discover potential genes and MicroRNAs(miRNAs) related to neuropathic pain by bioinformatics method. Microarray data of GSE69901 were obtained from Gene Expression Omnibus (GEO) database. Peripheral blood samples from patients with or without neuropathic pain after spinal cord injury (SCI) were collected. 12 samples with neuropathic pain and 13 samples without pain as control were included in the downloaded microarray. Differentially expressed genes (DEGs) between neuropathic pain group and control group were detected using GEO2R online tool. Functional enrichment analysis of DEGs was performed using DAVID database. Protein-protein interaction (PPI) network was constructed from STRING database. MiRNAs targeting these DEGs were obtained from miRNet database. A merged miRNA-DEG network was constructed and analyzed with Cytoscape software. Total 1134 DEGs were identified between patients with or without neuropathic pain(case and control) and 454 biological processes were enriched. We identified 4 targeted miRNAs, including mir-204-5p, mir-519d-3p, mir-20b-5p, mir-6838-5p, which may be the potential biomarker for SCI patients. Protein modification and regulation biological process of central nervous system may be a risk factor of in SCI patients. Certain genes and miRNAs may be potential biomarkers for the prediction of and potential targets for prevention and treatment of neuropathic pain after SCI.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http

  11. Hair analysis for the detection of drug use-is there potential for evasion?

    Science.gov (United States)

    Marrinan, Shanna; Roman-Urrestarazu, Andres; Naughton, Declan; Levari, Emerlinda; Collins, John; Chilcott, Robert; Bersani, Giuseppe; Corazza, Ornella

    2017-05-01

    Hair analysis for illicit substances is widely used to detect chronic drug consumption or abstention from drugs. Testees are increasingly seeking ways to avoid detection by using a variety of untested adulterant products (e.g., shampoos, cleansers) widely sold online. This study aims to investigate adulteration of hair samples and to assess effectiveness of such methods. The literature on hair test evasion was searched for on PubMed or MEDLINE, Psycinfo, and Google Scholar. Given the sparse nature of peer-reviewed data on this subject, results were integrated with a qualitative assessment of online sources, including user-orientated information or commercial websites, drug fora and "chat rooms". Over four million web sources were identified in a Google search by using "beat hair drug test" and the first 86 were monitored on regular basis and considered for further analysis. Attempts to influence hair test results are widespread. Various "shampoos," and "cleansers" among other products, were found for sale, which claim to remove analytes. Often advertised with aggressive marketing strategies, which include discounts, testimonials, and unsupported claims of efficacy. However, these products may pose serious health hazards and are also potentially toxic. In addition, many anecdotal reports suggest that Novel Psychoactive Substances are also consumed as an evasion technique, as these are not easily detectable via standard drug test. Recent changes on Novel Psychoactive Substances legislations such as New Psychoactive Bill in the UK might further challenge the testing process. Further research is needed by way of chemical analysis and trial of the adulterant products sold online and their effects as well as the development of more sophisticated hair testing techniques. Copyright © 2017 John Wiley & Sons, Ltd.

  12. Analysis of Pedagogic Potential of Electronic Educational Resources with Elements of Autodidactics

    Directory of Open Access Journals (Sweden)

    Igor A.

    2018-03-01

    Full Text Available Introduction: in recent years didactic properties of electronic educational resources undergo considerable changes, nevertheless, the question of studying of such complete phenomenon as “an electronic educational resource with autodidactics elements” remains open, despite sufficient scientific base of researches of the terms making this concept. Article purpose – determination of essence of electronic educational resources with autodidactics elements. Materials and Methods: the main method of research was the theoretical analysis of the pedagogical and psychological literature on the problem under study. We used the theoretical (analysis, synthesis, comparison and generalization methods, the method of interpretation, pedagogical modeling, and empirical methods (observation, testing, conversation, interview, analysis of students’ performance, pedagogical experiment, peer review. Results: we detected the advantages of electronic educational resources in comparison with traditional ones. The concept of autodidactics as applied to the subject of research is considered. Properties of electronic educational resources with a linear and nonlinear principle of construction are studied.The influence of the principle of construction on the development of the learners’ qualities is shown. We formulated an integral definition of electronic educational resources with elements of autodidactics, namely, the variability, adaptivity and cyclicity of training. A model of the teaching-learning process with electronic educational resources is developed. Discussion and Conclusions: further development of a problem will allow to define whether electronic educational resources with autodidactics elements pedagogical potential for realization of educational and self-educational activity of teachers have, to modify technological procedures taking into account age features of students, their specialties and features of the organization of process of training of

  13. Clarification of sugar beet juice using Cu2+ and Al3+ ions: Method of measurement residual solution turbidity and zeta potential

    OpenAIRE

    Kuljanin, Tatjana; Jevtić-Mučibabić, Rada; Ćurčić, Biljana; Nićetin, Milica; Filipović, Vladimir; Knežević, Violeta

    2013-01-01

    Processing of raw sugar beet juice and molasses are important operations which are used to remove pectin and protein substances in order to obtain the final product - white sugar. Separation of these compounds in our country is mostly done by compounds with calcium ion. Quantities of used limestone are very high (1 – 3 % w/w, calculated on the beet). The aim of study is application of coagulants with divalent and trivalent cations which cause the process of charge neutralization of pectin and...

  14. Potential physiological effects of pharmaceutical compounds in Atlantic salmon (Salmo salar) implied by transcriptomic analysis.

    Science.gov (United States)

    Hampel, Miriam; Alonso, Esteban; Aparicio, Irene; Bron, James E; Santos, Juan Luis; Taggart, John B; Leaver, Michael J

    2010-05-01

    Pharmaceuticals are emerging pollutants widely used in everyday urban activities which can be detected in surface, ground, and drinking waters. Their presence is derived from consumption of medicines, disposal of expired medications, release of treated and untreated urban effluents, and from the pharmaceutical industry. Their growing use has become an alarming environmental problem which potentially will become dangerous in the future. However, there is still a lack of knowledge about long-term effects in non-target organisms as well as for human health. Toxicity testing has indicated a relatively low acute toxicity to fish species, but no information is available on possible sublethal effects. This study provides data on the physiological pathways involved in the exposure of Atlantic salmon as representative test species to three pharmaceutical compounds found in ground, surface, and drinking waters based on the evaluation of the xenobiotic-induced impairment resulting in the activation and silencing of specific genes. Individuals of Atlantic salmon (Salmo salar) parr were exposed during 5 days to environmentally relevant concentrations of three representative pharmaceutical compounds with high consumption rates: the analgesic acetaminophen (54.77+/-34.67 microg L(-1)), the anticonvulsant carbamazepine (7.85+/-0.13 microg L(-1)), and the beta-blocker atenolol (11.08+/-7.98 microg L(-1)). Five immature males were selected for transcriptome analysis in brain tissues by means of a 17k salmon cDNA microarray. For this purpose, mRNA was isolated and reverse-transcribed into cDNA which was labeled with fluorescent dyes and hybridized against a common pool to the arrays. Lists of significantly up- and down-regulated candidate genes were submitted to KEGG (Kyoto Encyclopedia of Genes and Genomes) in order to analyze for induced pathways and to evaluate the usefulness of this method in cases of not completely annotated test organisms. Exposure during 5 days to

  15. THEORY OF GENERATIONS AS A TOOL FOR ANALYSIS, FORMATION AND DEVELOPMENT OF LABOUR POTENTIAL

    Directory of Open Access Journals (Sweden)

    I. M. Gurova

    2016-01-01

    Full Text Available The modern Strauss–Howe generational theory created at the intersection of economic, sociological, historical and psychological Sciences. She focuses primarily on difference of attitudes of generations, due to the specific social environment, corresponding to a certain period of time. Such a perspective on issues related to the human factor in the economy, has recently attracted interest not only from researchers, but also finds application for solving practical problems in some fields of business.Subject / theme. The article is devoted to one of the urgent contemporary socio-economic problems – the issue of the formation and development of labor potential. In this context, the theory of generations is offered by the authors as a tool for the study of qualitative parameters of human resources and the planning of future work opportunities in our country. In particular, the article considers the main aspects of the classical version of the Strauss–Howe generational theory and its Russian adaptation. Statistics describing the General demographics and working population of Russia from the point of view of generational groups. On this basis, a forecast is made of the labor potential of the country in the long term structure, review and compare the basic values and business characteristics of its constituent generations. Problem areas for which use of generational approach is rational are revealed and the corresponding recommendations are made.Objectives. The purpose of this article is justification of the possible application of provisions of modern theories of generations to identify and predict the dynamics of qualitative characteristics of the domestic workforce, as well as the prospects of its use in order to control the formation and development of labor potential.Methods. Methodological basis of the presented work make comparative and economic-statistical and socio-cultural methods of analysis.Results. In the framework of this article

  16. A transfer matrix method for the analysis of fractal quantum potentials

    International Nuclear Information System (INIS)

    Monsoriu, Juan A; Villatoro, Francisco R; Marin, Maria J; UrchueguIa, Javier F; Cordoba, Pedro Fernandez de

    2005-01-01

    The scattering properties of quantum particles on a sequence of potentials converging towards a fractal one are obtained by means of the transfer matrix method. The reflection coefficients for both the fractal potential and finite periodic potential are calculated and compared. It is shown that the reflection coefficient for the fractal potential has a self-similar structure associated with the fractal distribution of the potential whose degree of self-similarity has been quantified by means of the correlation function

  17. A transfer matrix method for the analysis of fractal quantum potentials

    Energy Technology Data Exchange (ETDEWEB)

    Monsoriu, Juan A [Departamento de Fisica Aplicada, Universidad Politecnica de Valencia, E-46022 Valencia (Spain); Villatoro, Francisco R [Departamento de Lenguajes y Ciencias de la Computacion, Universidad de Malaga, E-29071 Malaga (Spain); Marin, Maria J [Departamento de Termodinamica, Universitat de Valencia, E-46100 Burjassot (Spain); UrchueguIa, Javier F [Departamento de Fisica Aplicada, Universidad Politecnica de Valencia, E-46022 Valencia (Spain); Cordoba, Pedro Fernandez de [Departamento de Matematica Aplicada, Universidad Politecnica de Valencia, E-46022 Valencia (Spain)

    2005-07-01

    The scattering properties of quantum particles on a sequence of potentials converging towards a fractal one are obtained by means of the transfer matrix method. The reflection coefficients for both the fractal potential and finite periodic potential are calculated and compared. It is shown that the reflection coefficient for the fractal potential has a self-similar structure associated with the fractal distribution of the potential whose degree of self-similarity has been quantified by means of the correlation function.

  18. DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.

    Science.gov (United States)

    Ziv, Omer; Geacintov, Nicholas; Nakajima, Satoshi; Yasui, Akira; Livneh, Zvi

    2009-07-14

    Human cells tolerate UV-induced cyclobutane pyrimidine dimers (CPD) by translesion DNA synthesis (TLS), carried out by DNA polymerase eta, the POLH gene product. A deficiency in DNA polymerase eta due to germ-line mutations in POLH causes the hereditary disease xeroderma pigmentosum variant (XPV), which is characterized by sunlight sensitivity and extreme predisposition to sunlight-induced skin cancer. XPV cells are UV hypermutable due to the activity of mutagenic TLS across CPD, which explains the cancer predisposition of the patients. However, the identity of the backup polymerase that carries out this mutagenic TLS was unclear. Here, we show that DNA polymerase zeta cooperates with DNA polymerases kappa and iota to carry out error-prone TLS across a TT CPD. Moreover, DNA polymerases zeta and kappa, but not iota, protect XPV cells against UV cytotoxicity, independently of nucleotide excision repair. This presents an extreme example of benefit-risk balance in the activity of TLS polymerases, which provide protection against UV cytotoxicity at the cost of increased mutagenic load.

  19. Prince of zeta by Petar Konjović: Opera in five/four acts on the 125th anniversary of the composer's birth

    Directory of Open Access Journals (Sweden)

    Mosusova Nadežda

    2008-01-01

    Full Text Available Petar Konjović (Čurug, May 5, 1883 - Belgrade, October 1, 1970 stands out among Serbian composers as an author of instrumental and vocal compositions. Studies at the Prague Conservatory (1904-1906 acquainted Konjović with Czech music, Wagner's opus, and the Russian national-romantic school, which contributed to the evolution of his talent for both music and stage, enabling him to express his ideas more explicitly in operatic works. It was in the Prague that the second opera - Prince of Zeta - was conceived, with new musical vividness and dramatic appeal (first version composed 1906-1926, the second and final 1929-1939, followed by Koštana (1928, Peasants (1951 and Fatherland (1960. Konjović's mature operas are characterized by his masterful handling of form, both in close-ups and in detail, as well as his deeply individual assimilation of musical folklore into his work. The Prince of Zeta is not to be understood as a folk opera, but some main themes are directly derived from folk music, precisely from the Montenegrin folk songs quoted in the Mokranjac's Ninth Garland and treated in Konjović's post-romantic, almost expressionistic way, interwoven with some Italianate leitmotifs, so as to present the opera's two worlds, Montenegrin and Venetian. In the process of forming Konjović's operatic style, with vocal parts based mainly on the principle of declamation, the opera Prince of Zeta (first performed in Belgrade, 1929, conducted by Lovro von Matačić proved to be a work of great impact. Hardly anyone grasped then the wide sweep of inspiration which allowed the composer to set and to solve several important problems connected with music drama, essential also in his subsequent stage works. First of all, Konjović had to handle in his own way the verbal drama the prototype of his opera, Maxim Crnojević by the Serbian poet Laza Kostić (1841-1910. Permission came from the playwright in the first decade of the 1900, Prince of Zeta being partly

  20. Site-specific seismic probabilistic tsunami hazard analysis: performances and potential applications

    Science.gov (United States)

    Tonini, Roberto; Volpe, Manuela; Lorito, Stefano; Selva, Jacopo; Orefice, Simone; Graziani, Laura; Brizuela, Beatriz; Smedile, Alessandra; Romano, Fabrizio; De Martini, Paolo Marco; Maramai, Alessandra; Piatanesi, Alessio; Pantosti, Daniela

    2017-04-01

    Seismic Probabilistic Tsunami Hazard Analysis (SPTHA) provides probabilities to exceed different thresholds of tsunami hazard intensity, at a specific site or region and in a given time span, for tsunamis caused by seismic sources. Results obtained by SPTHA (i.e., probabilistic hazard curves and inundation maps) represent a very important input to risk analyses and land use planning. However, the large variability of source parameters implies the definition of a huge number of potential tsunami scenarios, whose omission could lead to a biased analysis. Moreover, tsunami propagation from source to target requires the use of very expensive numerical simulations. At regional scale, the computational cost can be reduced using assumptions on the tsunami modeling (i.e., neglecting non-linear effects, using coarse topo-bathymetric meshes, empirically extrapolating maximum wave heights on the coast). On the other hand, moving to local scale, a much higher resolution is required and such assumptions drop out, since detailed inundation maps require significantly greater computational resources. In this work we apply a multi-step method to perform a site-specific SPTHA which can be summarized in the following steps: i) to perform a regional hazard assessment to account for both the aleatory and epistemic uncertainties of the seismic source, by combining the use of an event tree and an ensemble modeling technique; ii) to apply a filtering procedure which use a cluster analysis to define a significantly reduced number of representative scenarios contributing to the hazard of a specific target site; iii) to perform high resolution numerical simulations only for these representative scenarios and for a subset of near field sources placed in very shallow waters and/or whose coseismic displacements induce ground uplift or subsidence at the target. The method is applied to three target areas in the Mediterranean located around the cities of Milazzo (Italy), Thessaloniki (Greece) and