Sample records for zakareviius arminas stanionis

  1. Investigating the Regulation and Potential Role of Nonhypoxic Hypoxia-Inducible Factor 1 (HIF-1) in Aromatase Inhibitor Resistant Breast Cancer


    obese and overweight patients with ER+ breast cancer to neoadjuvant aromatase inhibitor therapy. My role in this clinical trial is to analyze HIF-1 and...with drug resistance in different cancer cell types, including chronic myeloid leukemia cells (Zhao et al. Oncogene. 2010), gastric cancer cells (Liu...Hypoxia- Inducible Factor 1 (HIF-1) in Aromatase Inhibitor Resistant Breast Cancer PRINCIPAL INVESTIGATOR: Armina Kazi CONTRACTING

  2. Geological setting of the Paleoproterozoic Rosebel gold district, Guiana Shield, Suriname

    Daoust, Caroline; Voicu, Gabriel; Brisson, Harold; Gauthier, Michel


    The Rosebel gold district is hosted in a Paleoproterozoic greenstone belt of the Guiana Shield and has many characteristics that enable classification of the ores as an orogenic gold deposit. Host rocks have undergone several phases of deformation. However, gold deposition occurred late in the structural history of the belt, and is considered part of a late regional metallogenic event with respect to the geotectonic evolution of the Guiana Shield. Economic gold mineralization is hosted in felsic to mafic volcanic rocks and two sedimentary successions that are differentiated into turbiditic and arenitic depositional packages. The detailed lithostratigraphic characterization and the geochemistry enable the correlation of the local rock types with the Paramaka, the Armina, and the Rosebel formations respectively. The Rosebel district comprises eight discrete gold deposits distributed along two major structures. The northernmost structure is a sub-vertical WNW-ESE shear zone that preserves evidence of dextral strike-slip followed by normal faulting. The southern structure is an east-west reverse fault along which gold deposits are mainly hosted in the footwall. Gold mineralization is associated with quartz vein arrays developed along pre-existing structural heterogeneities, such as stratigraphic contacts and fold hinges. Four main sets of veins are recognized in the district: shear veins, north-south tension veins, stacks of north-dipping tension veins, and anticline-hosted tension veins. Mineralized quartz veins are typically associated with a wallrock alteration assemblage comprising sericite, chlorite, carbonate, tourmaline, pyrite, pyrrhotite, and plagioclase. The presence of a WNW-ESE dextral strike-slip structure, an east-west reverse fault, and north-south tension veins are consistent with the formation of a Riedel system during a simple shear event. All vein sets cut deformed sedimentary rocks that were deposited in a pull-apart basin, which together with their

  3. Neuropsychological and neuroimaging markers in prediction of cognitive impairment after ischemic stroke: a prospective follow-up study

    Mehrabian S


    Full Text Available Shima Mehrabian,1 Margarita Raycheva,1 Neli Petrova,2 Armina Janyan,3,4 Mariya Petrova,1 Latchezar Traykov1 1Clinic of Neurology, University Hospital Alexandrovska, Sofia, 2Clinic of Neurology, MHAT “Ruse”, Ruse, 3Research Center for Cognitive Science, Department of Cognitive Science and Psychology, New Bulgarian University, Sofia, Bulgaria; 4Laboratory for Cognitive Studies in Language, National Research Tomsk State University, Tomsk, Russia Background: There are few longitudinal studies with controversial results examining delayed changes in cognition after ischemic stroke and predictive values of neuropsychological and neuroimaging markers. Objective: The objectives of this study were to evaluate the delayed changes in cognition in poststroke patients and their relationship to the neuropsychological and neuroimaging markers measured during the acute poststroke phase. Methods: Eighty-five first-ever stroke inpatients (mean age 65.6±5.6 years without previous cognitive complaints were prospectively evaluated with a comprehensive neuropsychological battery at the 5th day and the 1st, 6th, and 12th months. A wide range of clinical, radiological, and neuropsychological variables were examined. Results: Our results showed significantly poorer performance on mini–mental state examination, memory, attention/executive functions, and processing speed in patients with stroke in comparison with stroke-free cognitively intact controls. Multiple regression analysis revealed that hippocampal atrophy is the strongest predictor of delayed cognitive impairment. Secondary divided subgroups according to Isaacs Set Test (IST score showed that patients with IST score ≤28 had different patterns of cognitive and neurological impairment after 1 year. Baseline impairments in attention/executive functions and memory were associated with development of dementia in poststroke patients. Conclusion: Executive functioning deficit appears to have a predictive power