Sample records for yutaka uchida takeo

  1. Exploración del modelo coronal MHD de Uchida

    Francile, C.; Castro, J. I.; Flores, M.

    We present an analysis of the MHD model of an isothermal solar corona with radially symmetrical magnetic field and gravity. The solution in the approximation "WKB" was presented by Uchida (1968). The model is ex- plored for different coronal conditions and heights of initial perturbation to study the propagation of coronal waves and reproduce the observed char- acteristics of phenomena such as Moreton waves. Finally we discuss the obtained results. FULL TEXT IN SPANISH

  2. Addressing disability in the health system at CARITAS Takeo Eye Hospital

    David Lewis


    Full Text Available In recent years, CARITAS Takeo Eye Hospital (CTEH in Cambodia has worked hard to be more inclusive of people with disabilities. While there have been some challenges along the way, the overall results of the new practices appear to be very positive.

  3. High prevalence of Opisthorchis viverrini infection in a riparian population in Takeo Province, Cambodia.

    Yong, Tai-Soon; Shin, Eun-Hee; Chai, Jong-Yil; Sohn, Woon-Mok; Eom, Keeseon S; Lee, Dong-Min; Park, Keunhee; Jeoung, Hoo-Gn; Hoang, Eui-Hyug; Lee, Yoon-Hee; Woo, Hyun-Ju; Lee, Ji-Hwa; Kang, Sin-Il; Cha, Jae-Ku; Lee, Keon-Hoon; Yoon, Cheong-Ha; Sinuon, Muth; Socheat, Duong


    Opisthorchis viverrini infection was found to be highly prevalent in 3 riverside villages (Ang Svay Chek A, B, and C) of the Prey Kabas District, Takeo Province. This area is located in the southern part of Cambodia, where the recovery of adult O. viverrini worms was recently reported. From May 2006 until May 2010, fecal examinations were performed on a total of 1,799 villagers using the Kato-Katz thick smear technique. In the 3 villages, the overall positive rate for helminth eggs ranged from 51.7 to 59.0% (av. 57.4%), and the percentage positive for O. viverrini was 46.4-50.6% (47.5%). Other helminths detected included hookworms (13.2%), echinostomes (2.9%), Trichuris trichiura (1.3%), Ascaris lumbricoides (0.6%), and Taenia spp. (0.06%). The prevalence of O. viverrini eggs appeared to reflect a lower infection in younger individuals (20 years). Men (50.4%) revealed a significantly higher (P=0.02) prevalence than women (44.3%). The Ang Svay Chek villages of the Prey Kabas District, Takeo Province, Cambodia have been confirmed to be a highly endemic area for human O. viverrini infection.

  4. Caught between Two Worlds: Themes of Family, Community, and Ethnic Identity in Yoshiko Uchida's Works for Children.

    Harada, Violet H.


    Discusses the work of Japanese-American writer Yoshiko Uchida, who accurately re-creates a sense of the past in her depictions of Japanese-Americans struggling to define their self-images. Examines Uchida's treatment of several sociocultural issues and themes reflected in her children's works dealing with pre-World War II and internment years. (RS)

  5. Prejudice and Pride: Japanese Americans in the Young Adult Novels of Yoshiko Uchida.

    McDiffett, Danton


    Discusses five books for young adults by author Yoshiko Uchida. Notes that these books, accessible to children in grades 5 and above, describe the prejudice against Japanese Americans, internment camps, and upheaval, sorrow, and anger spawned by the American government's racist actions. Shows how the books can prompt discussions about cultural…

  6. Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province.

    Schully, Kevin L; Berjohn, Catherine M; Prouty, Angela M; Fitkariwala, Amitha; Som, Tin; Sieng, Darith; Gregory, Michael J; Vaughn, Andrew; Kheng, Sim; Te, Vantha; Duplessis, Christopher A; Lawler, James V; Clark, Danielle V


    Melioidosis is a severe infectious disease caused by the gram-negative soil bacterium Burkholderia pseudomallei. Melioidosis is well known to be a major cause of morbidity and mortality in Southeast Asia, particularly in Thailand. However, melioidosis remains underreported in surrounding areas such as Cambodia. We report a case series of melioidosis in seven patients from Takeo Province, Cambodia. The patients, aged 24-65 years, were enrolled from May 2014 to May 2015 during a one year prospective study of sepsis at Takeo Provincial Hospital. They presented with fever, rigors, dyspnea, fatigue, diaphoresis, productive cough, and skin abscesses. Six of the seven patients were also hyponatremic. B. pseudomallei was cultured from the blood of six patients and the sputum of one patient. In this manuscript, we provide a detailed description of the clinical presentation, case management and laboratory confirmation of B. pseudomallei, as well as discuss the difficulties of identifying and treating melioidosis in low resource settings.

  7. [Work curve characteristics of preschool children by Uchida-Kraepelin psychodiagnostic test].

    Takimoto, T; Yamada, K; Aoyagi, Y


    The work curve characteristics of preschool children aged five and six, were examined by Uchida-Kraepelin psychodiagnostic test; Scores were the amount of work, the effect of rest, PF profile fluctuation score and the relations among them. Subjects were 476 kindergarteners aged five and six. The results were as follows: The amounts of work increased with age, and girls' amount of work was larger than that of boys. The effect of rest was seen in the children aged six, but not in the children aged five. PF score tended to decrease as the amount of work increased. There was a negative correlation between the effect of rest and PF score.

  8. Use of a rosch-uchida needle for recanalization of refractory dialysis-related central vein occlusion.

    Goo, Dong Erk; Kim, Yong Jae; Choi, Deuk Lin; Park, Sung Il; Yang, Seung Boo; Moon, Cheol; Song, Dan


    The purpose of this study was to evaluate our experience with the use of a Rösch-Uchida needle technique to recanalize central vein occlusion that cannot be traversed with a guidewire. We retrospectively evaluated 33 recanalization procedures performed with a Rösch-Uchida needle on 20 men and 13 women with central vein occlusion during the period January 1999-December 2008. The occlusions were in the subclavian vein (n = 29) and the brachiocephalic vein (n = 4). A 9- or 10-French Rösch-Uchida introducer sheath was advanced centrally to abut the occlusion. The Rösch-Uchida needle was directed and advanced toward a transfemoral angiographic catheter placed on the central side of the occlusion. After passage of a guidewire through the occlusion, balloon angioplasty and stent insertion were performed. The outcome measures evaluated were technical success rate, primary and secondary patency, and complication rate. The mean occlusion length was 1.73 +/- 0.8 cm. The rate of technical success of recanalization was 93.9% (31 of 33 procedures). The 3-, 6-, and 12-month primary patency rates were 43.6%, 24%, and 8%, and the 3-, 6-, and 12-month secondary patency rates were 77.4%, 68.8% and 55.9%. One patient reported shoulder pain lasting 2 weeks, which resolved with conservative treatment. Use of a Rösch-Uchida needle to recanalize central vein occlusion refractory to a traditional procedure is feasible and safe and can preserve the involved extremity for long-term hemodialysis.

  9. A Study of the Similarities and Differences between Arishima Takeo and Tolstoy%试论有岛武郎与托尔斯泰的异同



    Arishima Takeo and Lev Tolstoy, from different countries and different age one from Japan, and the other from Rus sia, shared some similarities but also many differences. Lev Tolstoy wrote many great works in his life including the famous War and Peace, Anna Karenina and Resurrection. People all over the world have been studying his life, his works and his thoughts. Arishima Takeo, an artist and writer, born in Tokyo, firstborn son of a bureaucrat of Okura Sho, dropped out of high school of Gakushuin before he began to study agronomy in Sapporo. In the prime of his life, Arishima Takeo started to write due to the death of his father and his wife and ended up in suicide in his middle age. As an important member of Shirakabaha School in Japan, he had more than twenty im- mortal books such as A Woman, The Descendant of Cain. He is a monument to the novels in the Taisho time. The fact shows that al though Arishima Takeo and Lev Tolstoy live in different countries, they are well - known all over the world which proves that they are both well known writers in literary world.%有岛武郎与托尔斯泰,尽管一个在日本,一个在沙皇俄国,而且时代相差50年,但是他们却有许多相似之处和不同之处。托尔斯泰一生完成了许多杰作,他的名著《战争与和平》、《安娜卡里尼娜》、《复活》风靡全球,历久不衰。研究它的思想,著作,生平的作者遍及全球,人才辈出;有岛武郎身为画家,小说家,生在东京,是大藏省官僚的长子,自学习院高等科辍学后,进札幌农学就学,壮年因生父及妻子之死的震撼,加入笔耕行列,中年自杀,结束了的生命,作为日本白桦派文学兴盛期的重要作家之一,发表《一个女人》、《该隐的末裔》等20篇不朽的杰作,是大正小说的一座丰碑。事实表明:有岛武郎与托尔斯泰尽管生在两个国度,却同样誉满全球,虽一个中年夭折,一位

  10. [Evaluation of the Uchida-Kräpelin psychodiagnostic test based on the Five-Factor Model of personality traits].

    Kashiwagi, S; Yamada, K


    A method was proposed for evaluating the Uchida-Kräpelin psychodiagnostic (UK) test in terms of the Five-Factor Model (FFM) of personality traits. First, the oblique incomplete procrustes factor-rotation method by Jöreskog (1965) was applied to the results of the Adjective Check List (ACL) and the UK test administered to 370 subjects. Six oblique primary pattern values for the UK test were obtained as related to the task of addition work and personality traits. Second, the basic statistics including the values of test-retest reliabilities for work-curve measures in the UK test were presented, and canonical correlation analysis was applied to the data based on both personality traits and work-curve measures. Finally, correlations between the items of the ACL and the work-curve measures in the UK test were presented in order to confirm the validity of the present proposal for the UK test based on the FFM of personality traits.


    Denise Penna Quintanilha


    Full Text Available This research was made for developing an analysis of teaching methods used by the artist in his "Painting Children with creativity” course and their importance for the region. The Art Education issue has been placed in high priority within the education system in Brazil and it can greatly contribute to the analysis of the methods of the most respected Art teachers in the Presidente Prudente region, whose memory will be lost for lack of proper recording. The main objectives were the recovery and identification of methods of teaching Art used by the artist and art educator Takeo Sawada highlighting his work and teaching experience and analysis of its methodology, contextualizing it in the current teaching practice. The research was conducted with 10 former students, family and friends from Presidente Prudente and the methodology employed was the case study, through records and interviews focused. It can be observed that his attitude towards the students was based on a subtle and sometimes unnoticed presence that, given the difficulties, did not point directly to the solution but it made the student discover it. It is hoped that this research shows a pattern of conduct that can serve as educational scholarships for the training of future art teachers.

  12. [A factor analytic study of the items for the personality description based on the principle of the three traits theory for the work curve of addition of the Uchida-Kraepelin psychodiagnostic test].

    Kashiwagi, S; Yanai, H; Aoki, T; Tamai, H; Tanaka, Y; Hokugoh, K


    An inventory form for the personality description based on the principle of the three traits theory for the work curve of the Uchida-Kraepelin psychodiagnostic test was investigated from the factor-analytic point of view. Three kinds of analyses were performed. First of all, the 66 items of the present form were administrated and a tentative orthogonal factor solution was obtained. Secondly, the 20 items for a simplified pattern in the sense of "simple structure" were selected based on the result of the first factor rotation, and the further orthogonal factor rotation was applied to the data based on the selected items so that the assumption for the three traits, primacy (A), variability (B), and, recency (C) were confirmed factor-analytically. Finally, in order to increase the number of items for providing an extended form for academic and practical use, more 10 items were added to the 20 items of the second analysis after applying the third orthogonal factor rotation so that the new form consisting of 30 items was obtained. Some relationships between the present work and the one of Eysenck and Eysenck (1968) were discussed.

  13. Ice-thawing Visit: New Opportunities for Closer China-Japan Trade Ties Exclusive Interview with Takeo Donoue, Economic Counsellor of Embassy of Japan in China

    Guo Yan; Sun Yongjian


    @@ At the invitation of the Japanese government, from April 11 to 13, Chinese Premier Wen Jiabao paid an official visit to Japan, which was described as an "ice-thawing journey", and launched talks with Japanese Prime Minister Shinzo Abe.

  14. Parasphingopyxis algicola sp. nov., isolated from a marine red alga Asparagopsis taxiformis and emended description of the genus Parasphingopyxis Uchida et al. 2012.

    Jeong, Sang Eun; Kim, Kyung Hyun; Baek, Kyunghwa; Jeon, Che Ok


    An aerobic, Gram-stain-negative, yellow-pigmented bacterium, designated strain ATAX6-5T, was isolated from a marine red alga, Asparagopsistaxiformis, in South Korea. Cells were non-motile rods showing catalase- and oxidase-positive reactions. Growth of strain ATAX6-5T was observed at 5-35 °C (optimum, 30 °C), at pH 6.0-9.5 (optimum, pH 7.0) and in the presence of 0-6.0 % (w/v) NaCl (optimum, 2 %). Ubiquinone-10 was detected as the sole isoprenoid quinone and C18 : 1ω7c, C16 : 0 and C17 : 1ω6c were identified as the major cellular fatty acids. Diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, sphingoglycolipid, phosphatidylcholine, an unknown phospholipid and four unknown glycolipids were detected as polar lipids. The G+C content of the genomic DNA was 60.4 mol%. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain ATAX6-5T formed a tight phylogenic lineage with Parasphingopyxis lamellibrachiae JAMH 0132T with a 100 % bootstrap value. Strain ATAX6-5T was most closely related to P. lamellibrachiae JAMH 0132T with a 96.9 % 16S rRNA gene sequence similarity. Based on phenotypic, chemotaxonomic and molecular features, strain ATAX6-5T clearly represents a novel species of the genus Parasphingopyxis, for which the name Parasphingopyxis algicola sp. nov. is proposed. The type strain is ATAX6-5T (=KACC 18993T=JCM 31719T). An emended description of the genus Parasphingopyxis is also proposed.

  15. FY 2001 new energy vision of the Kin Town area. Initial stage survey. Town with plenty of heart, happiness, good living environment and vitality in harmony with nature; 2001 nendo Kin cho chiiki shin energy vision shoki dankai chosa. Shizen to no chowa ni yoru kokoro yutaka de akaruku sumiyoi katsuryoku aru machi



    For working out a new energy vision in Kin Town, Okinawa Prefecture, study as an initial stage survey was conducted of the state of energy supply/demand of the town, existence amount of new energy, possibility of new energy introduction, etc. The energy consumption amount of Kim Town was estimated at 10.71 x 10{sup 10} kcal/y. By sector, it consisted of 5.10 x 10{sup 10} kcal in the transportation sector, 3.51 x 10{sup 10} kcal in the commercial/residential sector and 1.66 x 10{sup 10} kcal in the industrial sector. The rate of energy source was 55.3% of petroleum-base fuel, 40.6% of electric power and 4% of LP gas. The existence amount of new energy was estimated at 39,373 MWh, which is equivalent to 77.8% of the electric power consumption amount of the town. The existence amount of new energy is broken down into 31.4% of wind power generation, 30.3% of solar energy, 12.5% of photovoltaic power generation, 3.0% of waste utilization, etc. As to the program assuming the new energy introduction, a lot of themes were cited such as the introduction of photovoltaic power generation/wind power generation to around the hog raising complex, utilization of wind power/biomass energy in the stockbreeding industry and introduction of hybrid car to official vehicle. (NEDO)

  16. 棉铃虫齿唇姬蜂触角感器的扫描电镜观察%Scanning Electron Microscopy on the Antennal Sensilla of Campoletis chlorideae Uchida ( Hymenoptera: Ichneumonidae)

    刘万学; 万方浩



  17. Proceedings of International Wire and Cable Symposium (41st) Held in Reno, Nevada on November 16, 17, 18, and 19, 1992.


    and P. R. Foy, Fiber Optic Subscriber Loop-Y. Kurosawa , H. Sawano, M. Materials Research Program, Piscataway, NJ .......... 253 Miyamoto, N. Sato...Symposium Proceedings 1992 Development of Ribbon Loose Tube Cable for Optical Subscriber Loop Yutaka KUROSAWA , Hiroyuki SAWANO, Matsuhiro Japanese) Yutaka KUROSAWA Opto-Electronics Laboratory Opto-Electronics Fujikura LTD. Laboratory • " , oFujikura LTD. 񓗀 Mutsuzaki, Sakura-shi

  18. Perception for Outdoor Navigation


    purposes of obst *l avoidanc or path foowing are new writen int a map. Global, perumnt, map are hbodled by the sepam uci of *soowed map*. Annotmd is the product of many people. Takeo Kanade, William Whittaker, and Steve Shafer have all shared in Principal Investigator responsibilities...thaks especially to Takeo Kanade and William Whittaker, co-principal investigators-, to Jull Crisman, Martial Hebert, Dean Pomerleau, Didier Aubert

  19. Requirements for the Development of Bacillus Anthracis Spore Reference Materials Used to Test Detection Systems


    animals by polymerase chain reaction, J. Clinical Microbiol. 31, 547-551 (1993). [41] S.-I. Makino, H. I. Cheun, M. Watari , I. Uchida, and K. Takeshi...65] H .I. Cheun, S.-I. Makino, M. Watari , T. Shirahata, I. Uchida, and K. Takeshi, A simple and sensitive detection system for Bacillus anthracis in

  20. "Disappearance and Appearances"

    van der Meijden, Peter Alexander


    Artiklen beskriver samarbejdet mellem det amsterdamske galleri Art & Project, især kendt for sin tilknytning til konceptkunsten, og den japanske konceptkunstner Matsuzawa Yutaka. I fokus er de nye kuratoriske strategier der opstod i tiden omkring 1970 og deres grænser. Én af dem er den "konceptue...

  1. Dicty_cDB: Contig-U16050-1 [Dicty_cDB

    Full Text Available CF925127 ) Ml_MQ1_03E01_SKplus Mnemiopsis leidyi Gastrula st... 40 0.27 3 ( FF919404 ) CBWU60817.b1 Yutaka S..... 36 0.42 3 ( FC464969 ) CAXH2748.fwd CAXH Mnemiopsis leidyi whole animal ... 40 0.43 3 ( AC190187 ) Pan tr

  2. The Third Indochina Conflict: Cambodia’s Total War


    troop.34 The CGDK units operating in this area consisted of elements of the Khmer Rouge divisions (especially those in Preah Vihear province whose...and Preah Vihear . Front 979 was supported by Vietnam’s Military Region 9 and controlled operations in Takeo, Kompot, Kampong Som, Koh Kong, Kampong

  3. Ph.d. report nº1

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  4. A survey for potentially zoonotic gastrointestinal parasites of dogs and pigs in Cambodia

    Inpankaew, Tawin; Murrell, Kenneth Darwin; Pinyopanuwat, Nongnuch;


    There is little information available on parasites of zoonotic significance in Cambodia. In 2011, in an effort to obtain data on potentially zoonotic gastrointestinal parasites in domestic animals, 50 dogs and 30 pigs residing in 38 households located in Ang Svay Check village, Takeo province, Ca...

  5. Aquaculture Asia, Vol 9, No. 3, pp.1-52, July-September 2004


    CONTENTS: Genetic considerations in fisheries & aquaculture with regard to impacts upon biodiversity, by Thuy T. T. Nguyen. Rice-fish culture for food and environmental security, by by M.C. Nandeesha. [Farmers as Scientists series] Research and development on land-based aquaculture of spotted Babylon, Babylonia areolata in Thailand: Pilot hatcher-based seedling operation, by Nilnaj Chaitanawisuti Sirusa Kritsanapuntu, and Yutaka Natsukari. Native catfish culture - a boon to In...

  6. The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes

    Kurose T; Hyo T; Yabe D; Seino Y


    Takeshi Kurose, Takanori Hyo, Daisuke Yabe, Yutaka Seino Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Fukushima, Osaka, Japan Abstract: Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as d...

  7. Improvement of Image Quality in Transmission Computed Tomography Using Synchrotron Monochromatic X-Ray Sheet Beam


    7] T. Takeda, M. Kazama, T. Zeniya, T. Yuasa, M. Akiba, A. Uchida, K. Hyodo, T. Akatsuka, M. Ando, and Y. Itai , “Development of a Mono- chromatic X...Uyama (Springer-Verlag, Tokyo), pp. 103-110 (1998). [8] Y. Itai , T. Takeda, T. Akatsuka, T. Maeda, K. Hyodo, A. Uchida, T. Yuasa, M. Kazama, J. Wu...T. Yuasa, K. Hyodo, M. Ando, T. Akatsuka, and Y. Itai , “Performance Study of Monochromatic Synchro- tron X-ray Computed Tomography using a Linear

  8. Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.

    Nakata, M; Tang, W


    research in Asian countries. (reported on October 1st, with grateful thanks to all participants) Main program Session I. Research Advances in Drug Discoveries and Therapeutics ● Design, synthesis and preliminary activity assay of influenza virus neuraminidase inhibitors by Wenfang Xu (Shandong University, China) ● Infection disease models with silkworms to evaluate the therapeutic effects of drug candidates by Kazuhisa Sekimizu (The University of Tokyo, Japan) ● Japan's governmental approaches to facilitate drug development process by Makoto Shimoaraiso (Ministry of Foreign Affairs of Japan, Japan) ● Effective detection of the epidermal growth factor receptor mutation by the peptide nucleic acid-locked nucleic acid PCR Clamp by Sakuo Hoshi (The University of Tokyo Hospital, Japan) ● Design and synthesis of p53-MDM2 binding inhibitors by Yongzhou Hu (Zhejiang University, China) Session II. Drug Synthesis/Clinical Therapeutics ● Pharmacogenomics-based clinical studies using a novel fully-automated genotyping system by Setsuo Hasegawa (Sekino Clinical Pharmacology Clinic, Japan) ● Synthesis and biological evaluation of pentacyclic triterpenes as anti-tumor agents by Hongbin Sun (China Pharmaceutical University, China) ● Drug discovery and therapeutics using silkworm as experimental animal by Yasuyuki Ogata (The University of Tokyo, Japan) ● Novel selective estrogen recetpor modulators (SERMs) with unusual structure and biological activities by Haibing Zhou (Wuhan University, China) Session III. Medicinal Chemistry/Natural Products ● Synthesis and properties of isonucleosides incorporated oligonucleotides by Zhenjun Yang (Peking University, China) ● Isolation of antiviral compounds from plant resources using silkworm bioassay by Yutaka Orihara (The University of Tokyo, Japan) ● Synthesis and structural modifcation of tasiamide and the effect of these modifications on in vitro anticancer activity by Yingxia Li (Ocean University of China, China)

  9. Sharp Recanalization for Chronic Left Iliac Vein Occlusion

    Ito, Nobutake, E-mail:; Isfort, Peter; Penzkofer, Tobias [RWTH Aachen University, Department of Diagnostic and Interventional Radiology, University Hospital (Germany); Grommes, Jochen; Greiner, Andreas [RWTH Aachen University, Department of Vascular Surgery, University Hospital (Germany); Mahnken, Andreas [RWTH Aachen University, Department of Diagnostic and Interventional Radiology, University Hospital (Germany)


    Endovascular treatment has emerged as a first-line treatment for venous occlusions, but is sometimes challenging with conventional approaches. This article describes a helpful technique using a Roesch-Uchida needle to cross a chronic occlusion of the iliac vein when conventional techniques have failed.

  10. Theory of magnon-driven spin Seebeck effect

    Xiao, J.; Bauer, G.E.W.; Uchida, K.; Saitoh, E.; Maekawa, S.


    The spin Seebeck effect is a spin-motive force generated by a temperature gradient in a ferromagnet that can be detected via normal metal contacts through the inverse spin Hall effect [K. Uchida et al., Nature (London) 455, 778 (2008)]. We explain this effect by spin pumping at the contact that is p

  11. Eesti graafika edu Hispaanias / Benjamin Vasserman

    Vasserman, Benjamin


    Hispaanias Orenses dets. 1998/jaan. 1999 peetud V rahvusvahelisel graafikabiennaalil "Julio Prieto Nespereira auhind" pälvisid žürii kiituse eesti graafikud R. Saks, V. Tolli, B. Vasserman. I preemia ئ T. Uchida. Näitusel osales S. Liiva. 1998. a. sügisel Jaapanis toimunud II Tokio rahvusvahelisest väikegraafika triennaalist võttis osa N. Neidre.

  12. Two new species of the genus Arrenurus from Pohnpei, Federated States of Micronesia (Acari: Hydrchnidia: Arrenuridae)

    Harry Smit


    Few specimens of water mites have been collected from Pacific Island streams, especially higher elevation, head water streams. Uchida (1935, 1939) and Cook & Bright (1983) published 11 species of water mites from the Palau Islands, while Cook (1957) reported two Arrenurus species from the main island of Yap in the Caroline Island chain. Viets (...

  13. "Celebrate Women's History": Coloring Poster Activity Booklet.

    Ruthsdotter, Mary

    This booklet contains biographical information about Bessie Coleman, Nellie Bly, Gertrude Ederle, Sojourner Truth, Chien-Shiung Wu, Yoshiko Uchida, Madam C. J. Walker, Maria Martinez, Jovita Idar, Margaret Bourke-White, Sally Ride, and Sybil Ludington. These women are noted for their important contributions to United States history. It is hoped…

  14. M13 Bacteriophage-Polymer Nanoassemblies as Drug Delivery Vehicles


    mediated targeting of cowpea mosaic virus particles to tumor cells. Chem. Biol. 2007, 14, 1152–1162. [15] Young, M.; Willits, D.; Uchida, M.; Douglas, T...building blocks: Cysteine-added mutants of cowpea mosaic virus. Chem. Biol. 2002, 9, 813–819. [25] Koudelka, K. J.; Rae, C.; Manchester, M. A plant-virus

  15. Eesti graafika edu Hispaanias / Benjamin Vasserman

    Vasserman, Benjamin


    Hispaanias Orenses dets. 1998/jaan. 1999 peetud V rahvusvahelisel graafikabiennaalil "Julio Prieto Nespereira auhind" pälvisid žürii kiituse eesti graafikud R. Saks, V. Tolli, B. Vasserman. I preemia ئ T. Uchida. Näitusel osales S. Liiva. 1998. a. sügisel Jaapanis toimunud II Tokio rahvusvahelisest väikegraafika triennaalist võttis osa N. Neidre.

  16. Disease: H00967 [KEGG MEDICUS

    Full Text Available mon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki... Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami

  17. The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes

    Kurose T


    Full Text Available Takeshi Kurose, Takanori Hyo, Daisuke Yabe, Yutaka Seino Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Fukushima, Osaka, Japan Abstract: Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as diabetes, obesity, and hyperlipidemia. Here we review recent advances in research on circadian disruption, shift work, altered eating behaviors, and disrupted sleep-wake cycles, with reference to management of type 2 diabetes. Keywords: diabetes, clock gene, shift work, eating behavior, sleep loss

  18. International Semiconductor Laser Conference. Held in Boston, Massachusetts on August 29 - September 1, 1988


    195 0:3 2:30 pm Reduction of Spectral Chirping in Modulation Doped Multiquantum Well (MD-MQW) Lasers K. Uomi, N. Chinone, and T Mishima , Hitachi, Ltd...Wavelength Masayuki Ishikawa, Hajime Okuda, Hideo Shiozawa, Kazuhiko Itaya, Gen-ichi Hatakoshi, Yukio Watanabe, Koichi Nitta and Yutaka Uematsu...1987). 3 P. L. Derry, el al., Appl. Phys. Lett., 50, p. 1773 (1987). 4 K. Uomi, T. Mishima , and N. Chinone, Appi. Phye. Lett., 51, p. 78 (1987). 1.0 1.0

  19. Strategic Studies Quarterly. Volume 5, Number 2, Summer 2011


    Santa Monica, CA: RAND, 1998),; Ted R. Gurr, Peoples versus States: Minorities at Risk in the New...Beer Sheva, Israel: Ben-Gurion University Press, 2007). 37. Matthew Levitt , Hamas: Politics, Charity, and Terrorism in the Service of Jihad (New Haven...Newport, RI: Naval War College, 14 February 2005), 13, 15–16. 65. Lt Col Ted A. Uchida, USAF, Reforming the Interagency Process (Maxwell AFB, AL: Air

  20. A new species of Xorides Latreille (Hymenoptera, Ichneumonidae, Xoridinae parasitizing Pterolophia alternata (Coleoptera, Cerambycidae in Robinia pseudoacacia

    Mao-Ling Sheng


    Full Text Available A new species is described, Xorides benxicus Sheng, sp. n., reared from the cerambycid twig-boring pest of Robinia pseudoacacia Linnaeus, Pterolophia alternata Gressitt 1938, in Benxi County, Liaoning Province, China. A key is given to the species similar to Xorides benxicus Sheng, namely X. asiasius Sheng & Hilszczański 2009, X. cinnabarius Sheng & Hilszczański 2009 and X. sapporensis (Uchida 1928.

  1. Role of Plasma Temperature and Residence Time in Stagnation Plasma Synthesis of c-BN Nanopowders


    critical compressive stress model based off of sub- plantation , which in the energy range of thin film technology, ions loose energy by nuclear...interstitial positions. Lower energy species, however, stick to the outer surface and form sp 2 bonded sites. A thermal spike is seen for a very short ...temperature of 350°C, which produced ~98% c- BN. Uchida et al. 14 used a substrate at room temperature during an IVD process. The substrate was rotated

  2. Characteristics of High-Efficient InGaN-Based White LED Lighting


    UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO 11311 TITLE: Characteristics of High-Efficient InGaN -Based White LED ...thru ADP011332 UNCLASSIFIED Characteristics of high-efficient InGaN -based white LED lighting Yuji Uchida’, Tatsumi Setomoto’, Tsunemasa Taguchi...characteristics of an efficient white LEDs lighting source, which is composed of cannon-ball type 10 cd-class InGaN -based white LEDs , are described. It is

  3. Capsule Depolymerase Overexpression Reduces Bacillus anthracis Virulence


    reported to be secreted (Kimura et al., 2004), while B. anthracis CapD is membrane associated ( Candela & Fouet, 2005). The individual subunits of...the peptidoglycan layer ( Candela & Fouet, 2005; Makino et al., 2002; Uchida et al., 1993), specifically, to the side-chain amino group of mice and guinea pigs ( Candela & Fouet, 2005; Makino et al., 2002; Richter et al., 2009). These observa- tions led us to hypothesize that increased

  4. Your Criminal Fico Score


    1800s, when Dr. John Snow mapped cholera clusters in London that showed how the 1 Craig D. Uchida, A...when_was_the_first_census_in_the_united_states.html. 2 disease spread and opened the door to improved medical techniques.6 What is revolutionary about modern-day... solutions /collateral/service-provider/visual-networking-index-vni/VNI_Hyperconnectivity_WP.html. 8 Jacob Morgan, “A

  5. [An examination of "Minamata disease general investigation and research liaison council"--The process of making uncertain the organic mercury causal theory].

    Nakano, Hiroshi


    Minamata disease occurred because inhabitants consumed the polluted seafood. The official confirmation of Minamata disease was in 1956. However, the material cause of that disease was uncertain at that time. The Minamata Food Poisoning Sub-committee, under authority of the Food Hygiene Investigation Committee of the Ministry of Health and Welfare, determined the material cause of Minamata disease to be a certain kind of organic mercury in 1959. The sub-committee was dissolved after their report. The discussion about the investigation of the cause was performed in a conference initiated by the Economic Planning Agency, which was titled "Minamata Disease General Investigation and Research Liaison Council". The Participants were eight scientists; four fishery scientists, two chemists, and only two medical scientists, which implied that only examination of the organic mercury was to be discussion. The conference was held four times from 1960 to 1961. In the first and second conferences, the organic mercury research from a medical perspective progressed in cooperation with fishery sciences. In the third conference, it was reported that UCHIDA Makio, professor of Kumamoto University, had found organic mercury crystal in the shellfish found in Minamata-bay. Authorities of biochemistry and medicine in the third conference criticized UCHIDA's research. At the fourth conference, reports contradicting his research were presented. Although those anti-UCHIDA reports were not verified, AKAHORI Shiro, the highest authority of biochemistry, not only accepted them, but also expressed doubt in the organic mercury causal theory. Therefore, this theory was recognized as uncertain.

  6. Magnons, Spin Current and Spin Seebeck Effect

    Maekawa, Sadamichi


    When metals and semiconductors are placed in a temperature gradient, the electric voltage is generated. This mechanism to convert heat into electricity, the so-called Seebeck effect, has attracted much attention recently as the mechanism for utilizing wasted heat energy. [1]. Ferromagnetic insulators are good conductors of spin current, i.e., the flow of electron spins [2]. When they are placed in a temperature gradient, generated are magnons, spin current and the spin voltage [3], i.e., spin accumulation. Once the spin voltage is converted into the electric voltage by inverse spin Hall effect in attached metal films such as Pt, the electric voltage is obtained from heat energy [4-5]. This is called the spin Seebeck effect. Here, we present the linear-response theory of spin Seebeck effect based on the fluctuation-dissipation theorem [6-8] and discuss a variety of the devices. [4pt] [1] S. Maekawa et al, Physics of Transition Metal Oxides (Springer, 2004). [0pt] [2] S. Maekawa: Nature Materials 8, 777 (2009). [0pt] [3] Concept in Spin Electronics, eds. S. Maekawa (Oxford University Press, 2006). [0pt] [4] K. Uchida et al., Nature 455, 778 (2008). [0pt] [5] K. Uchida et al., Nature Materials 9, 894 (2010) [0pt] [6] H. Adachi et al., APL 97, 252506 (2010) and Phys. Rev. B 83, 094410 (2011). [0pt] [7] J. Ohe et al., Phys. Rev. B (2011) [0pt] [8] K. Uchida et al., Appl. Phys. Lett. 97, 104419 (2010).

  7. Living in the tide of change: Explaining Japanese subjective health from the socio-demographic

    Hidefumi eHitokoto


    Full Text Available Today, countries around the world are caught in the tide of change towards Gesellshaft, or individualistic socio-demographic condition. Recent investigations in Japan have suggested negative impacts of change on emotional and motivational aspects of the Japanese self (Norasakkunkit, Uchida, and Toivonen, 2012; Ogihara and Uchida, 2014. Building on previous findings, in Study 1, we measured socio-demographic change towards individualistic societal condition during 1990 to 2010—two decades marked by great economic recession—at the levels of prefecture and city using archival data. In Study 2, we tested whether Japanese adults’ general health, satisfaction with life, self-esteem, and perceived social support were negatively predicted by the change using social survey. Results of hierarchical linear modeling showed small but unique negative effects of the change on several health measures, suggesting that this change had an impact on health, above and beyond individual personality traits and demographics. Additionally, interdependent happiness, the type of cultural happiness grounded in interdependence of the self (Hitokoto and Uchida, 2014, showed an independent positive relationship with all aspects of health examined. Implications for health studies in changing socio-demographic condition are discussed in the context of Japanese society after economic crisis.

  8. A case of thyroid storm with cardiac arrest

    Nakashima Y


    Full Text Available Yutaka Nakashima,1 Tsuneaki Kenzaka,2 Masanobu Okayama,3 Eiji Kajii31Department for Support of Rural Medicine, Yamaguchi Grand Medical Center, 2Division of General Medicine, Center for Community Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan; 3Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University School of Medicine, Shimotsuke, JapanAbstract: A 23-year-old man became unconscious while jogging. He immediately received basic life support from a bystander and was transported to our hospital. On arrival, his spontaneous circulation had returned from a state of ventricular fibrillation and pulseless electrical activity. Following admission, hyperthyroidism led to a suspicion of thyroid storm, which was then diagnosed as a possible cause of the cardiac arrest. Although hyperthyroidism-induced cardiac arrest including ventricular fibrillation is rare, it should be considered when diagnosing the cause of treatable cardiac arrest.Keywords: hyperthyroidism, ventricular fibrillation, treatable cardiac arrest, cardiac arrest, cardiopulmonary arrest

  9. Dicty_cDB: Contig-U06860-1 [Dicty_cDB

    Full Text Available 8 0.009 2 ( DN292753 ) PL030011B20C06 cDNA from sexually mature hermapho... 48 0.010 2 ( DN298116 ) PL04011B...MH (pink hibiscus mealybug) Maco... 50 0.088 1 ( EJ019174 ) 1095439025895 Global-Ocean-Sampling_GS-26-01-01-...clone RP23-337F6, com... 46 1.4 1 ( AC120855 ) Mus musculus chromosome 18, clone RP23-270P23, co......60216 ) CAMPEP103A09 CAMPE Biomphalaria glabrata cDNA clo... 46 1.4 1 ( FF853266 ) CBWU4026.b1 Yutaka Satou ...s) Value (Q54VB3) RecName: Full=Ubiquinone biosynthesis protein COQ7 homo... 313 2e-84 AM393051_1( AM393051

  10. Editorial Statement--Action and Policy

    WU Guoxiong; WANG Huijun; Da-Lin ZHANG


    @@ On 16 March 2004, we received an appeal from Dr. Qing WANG of the United States' Naval Postgraduate School questioning the legitimacy of the paper entitled, Modeling Marine Stratocumulus with a Detailed Microphysical Scheme, that was published by ZHAO Chunsheng and Yutaka Ishizaka in the January 2004 issue of the Advances in Atmospheric Sciences (AAS). She pointed out that the model described in the paper was developed by her group in which the first author, Dr. Zhao, worked as a visiting scholar during February 1997-February 1998. The authors should not have claimed in the paper that they developed the model. In particular, they should not have published her group's work as their own. Thus, Dr. Wang requested that the paper be retracted from AAS.

  11. Dicty_cDB: Contig-U12146-1 [Dicty_cDB

    Full Text Available TCC 354... 86 1e-15 CP000614_2346( CP000614 |pid:none) Burkholderia vietnamiensis G4 c... 86 2e-15 CP000058_24( CP000058 |pid...) Methylobacterium extorquens AM1... 42 0.031 CP000615_1842( CP000615 |pid:none) Burkholderia vietnam...:none) Azotobacter vinelandii DJ, comple... 84 5e-15 FM209186_23( FM209186 |pid:none) Pseudomonas aerugin...hromobacterium violaceum ATCC ... 40 0.15 AL939117_280( AL939117 |pid:none) Streptomyces coelicolor A3(2) co...B284897 ) DF1717 Dermatophagoides farinae cDNA library Derm... 46 2.4 1 ( FF990576 ) CBWU108028.b1 Yutaka Satou unpublished cDNA li

  12. Respiratory failure caused by intrathoracic amoebiasis

    Toshinobu Yokoyama


    Full Text Available Toshinobu Yokoyama1, Masashi Hirokawa1, Yutaka Imamura2, Hisamichi Aizawa11Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University, Japan; 2Department of Hematology, St. Mary’s Hospital, Kurume, JapanAbstract: A 41-year-old male was admitted to the hospital with symptoms of diarrhea, fever and rapidly progressive respiratory distress. A chest radiograph and computed tomography (CT of the chest and the abdomen showed a large amount of right pleural effusion and a large liver abscess. The patient was thus diagnosed to have amoebic colitis, amoebic liver abscess and amoebic empyema complicated with an HIV infection. The patient demonstrated agranulocytosis caused by the administration of trimethoprim-sulfamethoxazole. However, the administration of granulocyte colony-stimulating factor made it possible for the patient to successfully recover from agranulocytosis, and he thereafter demonstrated a good clinical course.Keywords: amebiasis, amoebic empyema, HIV, agranulocytosis, trimethoprim-sulfamethoxazole

  13. Analysis by electrochemical impedance spectroscopy of new MCFC cathode materials

    Pérez, F. J.; Duday, D.; Hierro, M. P.; Gómez, C.; Romero, M.; Casais, M. T.; Alonso, J. A.; Martínez, M. J.; Daza, L.

    The corrosion and electrochemical behaviours of Li 1- xNi 1+ xO 2 and Li 1- x(Ni yCo 1- y) 1+ xO 2 oxides were investigated in a molten carbonate electrolyte at 650°C and compared with a NiO reference cathode material. These oxides are future candidate cathode materials for molten carbonate fuel cell (MCFC) and are divided in two families: monophasic oxides and biphasic oxides. The monophasic oxides show an important dissolution or a lower catalytic activity and are not good candidates for future use in MCFC. The biphasic oxides show a low dissolution and a good catalytic efficiency close to the NiO value. In this first study of new cathode materials by electrochemical impedance spectroscopy (EIS), it appears that the biphasic Li-Ni-Co-O oxides are the best candidates for MCFC. The MCFC electrochemical cathodic mechanism, taking into account the peroxide and the superoxide pathways and the O 2-, CO 2 and H 2O diffusion proposed in the bibliography [I. Uchida, T. Nishina, Y. Mugikura, K. Itaya, J. Electroanal. Chem., 206 (1986) 229; C. Yuh, J.R. Selman, AIChE J., 34(12) (1988) 1949; T. Nishina, I. Uchida, Proc. Symp. Molten Carbonate Fuel Cell Technol., The Electrochem. Soc., PV90-16 (1990) 438; T. Nishina, G. Lindbergh, T. Kudo, I. Uchida, The International Fuel Cell Conference Proceedings, NEDO (1992) 189-192], is used to discuss the EIS results. The limiting rate of the peroxide or/and superoxide reactions of the new oxides was compared with the NiO reference oxide.

  14. Percutaneous recanalization of refractory dialysis-related subclavian vein obstruction : a case with needle puncture

    Goo, Dong Erk; Kim, Dae Ho; Choi, Deuk Lin [College of Medicine, Soonchunhyang University, Seoul (Korea, Republic of)


    Chronic central venous occlusion presents a difficult management problem, particularly when the occlusion cannot be traversed with a guide wire, a step which is essential for endovascular treatment such as balloon angioplasty and stent placement. We describe a less invasive technique in which the venous occlusion is traversed with a Rosch-Uchida Transjugular Liver Access Set. This procedure may be useful in cases where the involved extremity must be preserved for hemodialysis and where subclavian vein occlusion is refractory to traditional revascularization methods. (author)

  15. Vasserman ja Keerend rahvusvahelistel näitustel / Benjamin Vasserman

    Vasserman, Benjamin


    17. VI-2. IX Kanada Quebeci provintsis Trois-Riviere'is toimuval II rahvusvahelisel graafikabiennaalil osaleb Benjamin Vasserman 7 graafilise lehega. Peapreemia - Tomoya Uchida graafiline sari "Nest". Valiknäituse "Triennial of One Hundred Cities" esimesel väljapanekul Dzierzoniowis osalesid Avo Keerend ja B. Vasserman, A. Keerendi töö "Vastasseis XII" on avaldatud näituse bukleti esikaanel. Itaalias Pisas 7.-14. VII toimunud III ülemaailmsel väikegraafika ja -maali näitusel "ITART 2001" pälvis B. Vassermani "Finalist" diplomi ja õiguse osaleda finalistide preemianäitusel Livornos.

  16. Vasserman ja Keerend rahvusvahelistel näitustel / Benjamin Vasserman

    Vasserman, Benjamin


    17. VI-2. IX Kanada Quebeci provintsis Trois-Riviere'is toimuval II rahvusvahelisel graafikabiennaalil osaleb Benjamin Vasserman 7 graafilise lehega. Peapreemia - Tomoya Uchida graafiline sari "Nest". Valiknäituse "Triennial of One Hundred Cities" esimesel väljapanekul Dzierzoniowis osalesid Avo Keerend ja B. Vasserman, A. Keerendi töö "Vastasseis XII" on avaldatud näituse bukleti esikaanel. Itaalias Pisas 7.-14. VII toimunud III ülemaailmsel väikegraafika ja -maali näitusel "ITART 2001" pälvis B. Vassermani "Finalist" diplomi ja õiguse osaleda finalistide preemianäitusel Livornos.

  17. The magnetic properties of S={1}/{2} quasi-one-dimensional-quantum spin system DMACuCl3 in magnetic fields

    Wada, Osamu; Yoshida, Yasuo; Inagaki, Yuji; Asano, Takayuki; Kawae, Tatsuya; Takeda, Kazuyoshi; Ajiro, Yoshitami

    Magnetic susceptibility χ(T) of a quasi-one-dimensional S={1}/{2} quantum spin system DMACuCl3 (DMA=(CH 3) 2NH 2) has been measured in a magnetic field. This compound exhibits a unique magnetization curve M(H). M(H) rises with increasing magnetic field up to H=2 T, and shows a {1}/{2} plateau between H and H=3.5 T followed by a gradual increase to the saturation at Hs=14 T. In the previous studies, the specific heat C(T) shows a sharp peak in the low field region for H⩽H and in the high field region for H⩽H [Y. Yoshida, O. Wada, Y. Inagaki, T. Asano, K. Takeo, T. Kawae, K. Takeda, Y. Ajiro, J. Phys. Soc. Japan 74 (2005) 2917. [1

  18. Diagnostic Narrative in the DSM-IV Casebook.

    Wood, Mary Elene


    On admission to the psychiatric hospital, Louise sat with her hands tightly clasped in her lap and avoided looking at the doctor who interviewed her. She answered questions readily and did not appear suspicious or guarded, but her affect was shallow. She denied depressed mood, delusions, or hallucinations. However, her answers became increasingly idiosyncratic and irrelevant as the interview progressed. In response to a question about her strange cooking habits, she replied that she did not wish to discuss recent events in Russia. When discussing her decline in functioning, she said, 'There's more of a take-o mechanism when you're younger.' Asked about ideas of reference, she said, 'I doubt it's true, but if one knows the writers involved, it could be an element that would be directed in a comical way.' Her answers were interspersed with the mantra, 'I'm safe. I'm safe.'

  19. Living in the tide of change: explaining Japanese subjective health from the socio-demographic change

    Hitokoto, Hidefumi; Tanaka-Matsumi, Junko


    Today, countries around the world are caught in the tide of change toward Gesellshaft, or individualistic socio-demographic condition. Recent investigations in Japan have suggested negative impacts of change on emotional and motivational aspects of the Japanese self (Norasakkunkit et al., 2012; Ogihara and Uchida, 2014). Building on previous findings, in Study 1, we measured socio-demographic change toward individualistic societal condition during 1990–2010—two decades marked by great economic recession—at the levels of prefecture and city using archival data. In Study 2, we tested whether Japanese adults' general health, satisfaction with life, self-esteem, and perceived social support were negatively predicted by the change using social survey. Results of hierarchical linear modeling showed small but unique negative effects of the change on several health measures, suggesting that this change had an impact on health, above and beyond individual personality traits, and demographics. Additionally, interdependent happiness, the type of cultural happiness grounded in interdependence of the self (Hitokoto and Uchida, 2014), showed an independent positive relationship with all aspects of health examined. Implications for health studies in changing socio-demographic condition are discussed in the context of Japanese society after economic crisis. PMID:25400604

  20. Analysis study of the condensation heat transfer coefficient in the presence of noncondensable on PCCS vertical condenser tube using MARS-KS

    Choi, Dong jae; Jang, Yeong jun; Lee, Yeon-Gun [Jeju National University, Jeju (Korea, Republic of); Kim, Sin [Chung-Ang University, Seoul (Korea, Republic of)


    The Passive Containment Cooling System (PCCS) to be introduced in advanced LWRs removes released energy to an external heat sink by a naturally driven flow. Containment through the condensation heat transfer phenomenon in the event of the loss of coolant accident (LOCA) or main steam line break (MSLB). As the released steam pressurizes the containment, the PCCS will activate to transport the decay heat In this study, a numerical analysis of the condensation heat transfer coefficients on the PCCS condenser tube is conducted using the MARS-KS code. The condensation heat transfer coefficients are obtained from JNU condensation tests performed on a 1000 long and 40 mm O.D. tube. The analysis condition covers 2 and 4 bar for the air mass fraction ranging from 0.1 to 0.8. The JNU single vertical condensation experimental results, Uchida's and Dehbi's correlation compared with the MARS-KS code's results at 2 and 4 bar. Experimental results and MARS-KS predicted heat transfer coefficient is different from the thermal resistances and Wall subcooling. An average relative error is 18.8% and 15% at 2 and 4 bar, respectively. Uchida's correlation is considered the noncondensable gas mass fraction only. Therefore, that is lower than MARS-KS results at 4 bar. Dehbi's correlation affected by ratio of the height-to-diameter, so its results are higher condensation heat transfer coefficient than MARS-KS predicted results.

  1. Study of condensation heat transfer following a main steam line break inside containment

    Cho, J.H.; Elia, F.A. Jr.; Lischer, D.J. [Stone & Webster Engineering Corporation, Boston, MA (United States)


    An alternative model for calculating condensation heat transfer following a main stream line break (MSLB) accident is proposed. The proposed model predictions and the current regulatory model predictions are compared to the results of the Carolinas Virginia Tube Reactor (CVTR) test. The very conservative results predicted by the current regulatory model result from: (1) low estimate of the condensation heat transfer coefficient by the Uchida correlation and (2) neglecting the convective contribution to the overall heat transfer. Neglecting the convection overestimates the mass of steam being condensed and does not permit the calculation of additional convective heat transfer resulting from superheated conditions. In this study, the Uchida correlation is used, but correction factors for the effects of convection an superheat are derived. The proposed model uses heat and mass transfer analogy methods to estimate to convective fraction of the total heat transfer and bases the steam removal rate on the condensation heat transfer portion only. The results predicted by the proposed model are shown to be conservative and more accurate than those predicted by the current regulatory model when compared with the results of the CVTR test. Results for typical pressurized water reactors indicate that the proposed model provides a basis for lowering the equipment qualification temperature envelope, particularly at later times following the accident.

  2. The Study on the Relationship between Serum Vascular Endothelial Growth Factor and Proteinuria in Adriamycin-induced Nephrotic Rats

    ZHU; Zhonghua(


    [1]Carmeliet P Collen D.Molecular analysis of blood vessel formation and disease.Am J Physiol 1997 273 :H2091[2]Gleade J M Ebert B L Firth J D.Regulation of angiogenic growth factor expression by hypoxia transition metals and chelating agents.Am J Physiol 1995 268:C1362[3]Uchida K Uchida S.Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor.AmJPhysiol 1994 266:F240[4]Simon M Grone H J Johren O.Expression of vascular endotheial growth factor and its receptors in human renal ontogenetis and adult kidney.Am J Physiol 1995 268:F81[5]Bailey E Bottomley M J.Vascular endothelial growth factor mRNA expression in minimal change membranous and diabetic nephrothy demonstrated by non-isotopic in situ hybridization.J Clin Pathol 1999 52:735[6]Nicholas J A Webb N J Waston C J.Circulation vascular endotheial growth factor is not increased during relapses of steroid-sensitive nephrotic syndrome.Kidney Int 1999 55:1063[7]Shulman K Rosen S Tognazzi K.Expression of VPF is altered in many glomerulous disease.J Am Soc Nephrol 1996 7:661

  3. Prediction of ThAI TH-13 Experiment Using CFX User Defined Function

    Ha, Jeong Hee; Hong, Soon Joon [FNC Technology, Yongin (Korea, Republic of); Park, Chun Tae [KAERI, Daejeon (Korea, Republic of)


    Steam with high energy and non-condensable gas induce very complex behaviors of the atmosphere inside the containment which include condensation and evaporation phenomena when an accident happens such as LOCA (Loss-Of-Coolant-Accident). Prediction of these complicated behaviors of the atmosphere inside the containment is highly important when designing a device to prevent rapid pressure increase like a passive heat exchanger in the containment. In this paper, ThAI-TH13 experiment was simulated using the ANSYS-CFX15.0. The wall condensation was modeled using Uchida correlation in a single-phase calculation by User-Defined Functions included in the CFX. A similar study was performed using CFX as described in Ref. 3. The purpose of this study is to obtain detail methods and analytical technology of the previous study throughout reproduction of the simulation. Also this study is a preliminary calculation to simulate behaviors of atmosphere in the containment based on the recreation of the previous study. ThAI-TH13 experiment was simulated using CFX based on the previous study. The wall condensation has been modeled in the single-phase simulation using Uchida correlation by user-fortran routines in CFX code. The results of this simulation predicted TH-13 experiment properly and physically in pressure distribution of the atmosphere in a THAI vessel.

  4. A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis

    Arimoto M


    Full Text Available Miyoko Arimoto1, Yutaka Komiyama2, Fumiko Okamae1, Akemi Ichibe1, Setsuko Teranishi1, Hirohiko Tokunaga1, Keiko Nakaya3, Michie Fujiwara3, Manabu Yamaoka4, Shuji Onishi4, Rie Miyamoto5, Naoto Nakamichi5, Shosaku Nomura51Blood Transfusion Unit, Kansai Medical University Takii Hospital, 2Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, 3Clinical Medical Technology Unit, Kansai Medical University Takii Hospital, 4Blood Transfusion Unit, Kansai Medical University Hirakata Hospital, 5First Department of Internal Medicine, Kansai Medical University, Moriguchi, JapanAbstract: Thrombotic thrombocytopenic purpura (TTP is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made.Keywords: thrombotic thrombocytopenic purpura, ADAMTS13, acute pancreatitis, plasma exchange

  5. Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia

    Balasubramanian S


    Full Text Available Sivakumar Balasubramanian,1 Aswathy Ravindran Girija,1 Yutaka Nagaoka,1 Seiki Iwai,1 Masashi Suzuki,1 Venugopal Kizhikkilot,2 Yasuhiko Yoshida,1 Toru Maekawa,1 Sakthikumar Dasappan Nair1 1Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan; 2Department of Respiratory Medicine, Sooriya Hospital, Chennai, India Abstract: The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU] and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes by initiating early and late apoptosis. Keywords: nanotechnology, curcumin, 5FU, folate, transferrin, PLGA nanoparticle, magnetic hyperthermia

  6. Which Dynamic Rupture Parameters can be Resolved?

    Peyrat, S.; Olsen, K.; Madariaga, R.


    We use finite-difference simulations in models of the 1992 Mw 7.3 Landers earthquake to examine which dynamic rupture parameters may be recovered for large crustal earthquakes. By trial-and-error inversion Peyrat et al. (2001) found two simple models with constant slip-weakening friction which generated a satisfactory fit between synthetic and observed strong motion data: an asperity model, with spatially-varying initial stress and constant yield stress, and a barrier model with constant initial stress and spatially-varying yield stress. However, there is some evidence from inversion of seismic data for large earthquakes (i.e., Ide and Takeo, 1997, for the 1995 Kobe earthquake), that the slip-weakening distance Dc may vary spatially. In particular, Ide and Takeo found a larger Dc in the shallower parts of the crust compared to the deeper parts. Possible causes of such variation include the increase of elastic rigidity with depth and a fundamentally different friction in the near-surface layers. Here, we examine the effects of laterally and vertically varying Dc on the strong motion synthetics computed by our dynamic rupture models. We generate an alternative barrier model with constant initial and yield stress but spatially-varying Dc which, as our two previous rupture models of the Landers event, generate synthetics in agreement with strong motion data. Thus, we have constructed three well-posed mechanical models of the Landers earthquake that satisfy available strong motion data and which are end-members of a large family of dynamically correct models. Our findings confirm an earlier hypothesis that barrier and asperity models of an earthquake generate similar signature in the seismic radiation (Madariaga, 1979). Therefore, it may not be possible to separate stress and Dc using rupture modeling. Instead, we propose to characterize dynamic rupture propagation by the local non-dimensional parameter κ introduced by Madariaga and Olsen (2000), which is expressed in

  7. Rapid assessment of injection practices in Cambodia, 2002

    Goldstein Susan


    Full Text Available Abstract Background Injection overuse and unsafe injection practices facilitate transmission of bloodborne pathogens such as hepatitis B virus (HBV, hepatitis C virus (HCV, and human immunodeficiency virus (HIV. Anecdotal reports of unsafe and unnecessary therapeutic injections and the high prevalence of HBV (8.0%, HCV (6.5%, and HIV (2.6% infection in Cambodia have raised concern over injection safety. To estimate the magnitude and patterns of such practices, a rapid assessment of injection practices was conducted. Methods We surveyed a random sample of the general population in Takeo Province and convenience samples of prescribers and injection providers in Takeo Province and Phnom Penh city regarding injection-related knowledge, attitudes, and practices. Injection providers were observed administering injections. Data were collected using standardized methods adapted from the World Health Organization safe injection assessment guidelines. Results Among the general population sample (n = 500, the overall injection rate was 5.9 injections per person-year, with 40% of participants reporting receipt of ≥ 1 injection during the previous 6 months. Therapeutic injections, intravenous infusions, and immunizations accounted for 74%, 16% and 10% of injections, respectively. The majority (>85% of injections were received in the private sector. All participants who recalled their last injection reported the injection was administered with a newly opened disposable syringe and needle. Prescribers (n = 60 reported that 47% of the total prescriptions they wrote included a therapeutic injection or infusion. Among injection providers (n = 60, 58% recapped the syringe after use and 13% did not dispose of the used needle and syringe appropriately. Over half (53% of the providers reported a needlestick injury during the previous 12 months. Ninety percent of prescribers and injection providers were aware HBV, HCV, and HIV were transmitted through unsafe

  8. Measuring an electron beam's orbital angular momentum spectrum

    Grillo, incenzo; Venturi, Federico; Larocque, Hugo; Balboni, Roberto; Gazzadi, Gian Carlo; Frabboni, Stefano; Lu, Peng-Han; Mafakheri, Erfan; Bouchard, Frédéric; Dunin-Borkowski, Rafal E; Boyd, Robert W; Lavery, Martin P J; Padgett, Miles J; Karimi, Ebrahim


    Quantum complementarity states that particles, e.g. electrons, can exhibit wave-like properties such as diffraction and interference upon propagation. \\textit{Electron waves} defined by a helical wavefront are referred to as twisted electrons~\\cite{uchida:10,verbeeck:10,mcmorran:11}. These electrons are also characterised by a quantized and unbounded magnetic dipole moment parallel to their propagation direction, as they possess a net charge of $-|e|$~\\cite{bliokh:07}. When interacting with magnetic materials, the wavefunctions of twisted electrons are inherently modified~\\cite{lloyd:12b,schattschneider:14a,asenjo:14}. Such variations therefore motivate the need to analyze electron wavefunctions, especially their wavefronts, in order to obtain information regarding the material's structure~\\cite{harris:15}. Here, we propose, design, and demonstrate the performance of a device for measuring an electron's azimuthal wavefunction, i.e. its orbital angular momentum (OAM) content. Our device consists of nanoscale h...

  9. Bioavailability assessment of metals chelated as proteinates using the Ussing Chamber Model

    G. Piva


    Full Text Available Preparation of proteinates by hydrolysis of organic matter produces a blend of different proteins, and may likely result in the chelation of trace elements. Often this process results in an increased bioavailability of minerals, leading to a higher absorption rate than inorganic salts (Cao et al., 2000; Uchida et al., 2001; Bailey et al., 2001; Guo et al., 2001. Usually trace elements uptake takes place along the small intestine, mainly jejunum (Tapia et al., 1996; Arredondo et al., 2000, even if the precise mechanisms underlying transport are not well understood. If these complexes are formed among metals and amino acids, they could be easily transported across the intestinal membrane by amino acids carriers..............

  10. Hydromedusae from the Arctic in 2010 during the 4th Chinese National Arctic Research Expedition (CHINARE 4)

    WANG Chunguang; HUANG Jiaqi; XIANG Peng; WANG Yanguo; XU Zhenzu; GUO Donghui; LIN Mao


    Fifty-seven stations (48 grid stations and nine stratified stations) were sampled across the study region (67.000°-88.394°N, 152.500°-178.643°W ) during the 4th Chinese National Arctic Research Expedition (CHI-NARE 4) from July to August 2010 by the icebreaker R/V Xuelong. A total of 24 species of Hydromedusae were identified from 130 zooplankton samples, of which seven species belonged to Automedusa, eight species to Anthomedusae, four species to Leptomedudae, and three species to Siphonophora. Catablema multicir-ratum Kishinouye, 1910, Bougainvillia bitentaculata Uchida, 1925, and Euphysa japonica (Maas, 1909) were recorded for the first time in the Arctic sea. In the present paper, 18 species of Hydromedusae were described and illustrated, of which three species were described for the first time in the Arctic sea, and 15 species were described for the first time in China.

  11. Carbon nanotube quantum dots as highly sensitive THz spectrometers

    Rinzan, Mohamed; Jenkins, Greg; Drew, Dennis; Shafranjuk, Serhii; Barbara, Paola


    We show that carbon nanotube quantum dots (CNT-Dots) coupled to antennas are extremely sensitive, broad-band, terahertz quantum detectors. Their response is due to photon-assisted single-electron tunneling (PASET)[1], but cannot be fully understood with orthodox PASET models[2]. We consider intra-dot excitations and non-equilibrium cooling to explain the anomalous response. REFERENCES: [1] Y. Kawano, S. Toyokawa, T. Uchida and K. Ishibashi, THz photon assisted tunneling in carbon-nanotube quantum dots, Journal of Applied Physics 103, 034307 (2008). [2] P. K. Tien and J. P. Gordon, Multiphoton Process Observed in the Interaction of Microwave Fields with the Tunneling between Superconductor Films, Phys. Rev. 129, 647 (1963).

  12. Experimental study of condensation heat transfer in the presence of noncondensable gas on the vertical tube

    Jang, Yeong-Jun; Choi, Dong-Jae; Lee, Yeon-Gun [Jeju National University, Jeju (Korea, Republic of); Kim, Sin [Chung-Ang University, Seoul (Korea, Republic of)


    The Passive Containment Cooling System (PCCS) that will be introduced in the next generation nuclear power plant removes released energy to containment through the condensation heat transfer phenomenon in the event of the loss of coolant accident(LOCA) or main steam line break(MSLB). The released steam is mixed with the air inside the containment and condensed on the tube bundle's outer surface of PCCS. In this study, an experimental study is performed to investigate the condensation heat transfer in the presence of noncondensable gas on vertical tube. Experiments were conducted using a tube with 1000 mm in length and 40 mm in outer diameter tube. The experimental data are obtained at pressure of 2, 3, 4 bar and the air mass fraction varied from 0.1 to 0.7. The experimental results are compared to the prediction of existing correlations. In a vertical tube with 40 mm in O.D. and 1000 mm in height, three sets of experiments to measure the condensation heat transfer coefficient are performed at 2, 3, 4 bar. Experimental results show that the condensation heat transfer coefficient reduces with an increase of the noncondensable mass fraction. The results are compared with the prediction of existing correlations by Uchida, Tagami and Dehbi. The compared result shows that these correlations underestimate the experimental results. That's because Uchida's and Tagami's correlations do not reflect all the effects of primary physical parameters and Dehbi's experiment did not maintain the uniform gas mixtures state inside chamber and has significant wall temperature gradient along the tube height. As further works, a new correlation will be proposed based on the experimental results. In addition, the heat transfer enhancement by using a finned tube is to be experimentally investigated.

  13. A survey for potentially zoonotic gastrointestinal parasites of dogs and pigs in Cambodia.

    Inpankaew, Tawin; Murrell, K Darwin; Pinyopanuwat, Nongnuch; Chhoun, Chamnan; Khov, Kuong; Sem, Tharin; Sorn, San; Muth, Sinuon; Dalsgaard, Anders


    There is little information available on parasites of zoonotic significance in Cambodia. In 2011, in an effort to obtain data on potentially zoonotic gastrointestinal parasites in domestic animals, 50 dogs and 30 pigs residing in 38 households located in Ang Svay Check village, Takeo province, Cambodia were examined for parasites from faecal samples. The samples were processed using the formalin-ethyl acetate concentration technique (FECT). Hookworms were the most common zoonotic parasite found in dogs (80.0%) followed by Echinostomes (18.0%). While, in pigs, Fasciolopsis buski was the most common zoonotic parasite (30.0%) followed by Ascaris suum (13.3%). This study provides baseline data on gastrointestinal parasites in dogs and pigs from Cambodia and underscores the importance of domestic animals as reservoir hosts for human parasites for Cambodian veterinary and public health agencies. Follow-up studies are required to further taxonomically characterize these dog and pig parasites and to determine their role in human parasites in this community.

  14. Prevalence of Opisthorchis viverrini infection in humans and fish in Kratie Province, Cambodia.

    Sohn, Woon-Mok; Yong, Tai-Soon; Eom, Keeseon S; Pyo, Kyoung-Ho; Lee, Mi Youn; Lim, Hyemi; Choe, Seongjun; Jeong, Hoo-Gn; Sinuon, Muth; Socheat, Duong; Chai, Jong-Yil


    Opisthorchis viverrini is a medically important foodborne parasite in the Indochina Peninsula. In Cambodia, the prevalence of this trematode has been reported in Takeo Province, but not in other areas. In this study, we investigated the prevalence of O. viverrini infection among people in seven riparian villages along the Mekong River, Kratie Province. We also examined the status of metacercarial infection in fish hosts. Fecal specimens were collected from 2101 residents and schoolchildren, and were examined by the Kato-Katz technique. The average O. viverrini egg positive rate was 4.6%, with the highest prevalence found in Roka Kandal A village (10.4%) followed by Talous village (5.9%). In these villages, adult residents showed higher prevalences (19.4% and 9.0%, respectively) than schoolchildren (6.4% and 1.4%, respectively). O. viverrini adult worms were recovered from 2 egg-positive cases (18 and 4 specimens) after praziquantel treatment and purgation. In addition, three of seven freshwater fish species caught near the villages were positive for O. viverrini metacercariae. A total of 367 metacercariae were harvested from 19 infected fish (metacercarial density; 19 per fish). The species of the metacercariae was confirmed through adult worm recovery by experimental infection to hamsters. The results provide evidence that the surveyed areas of Kratie Province, Cambodia, are endemic for O. viverrini infection.

  15. FY 1999 report on the survey of the history/inheritance of industrial technology. Survey of originality and creativity in machine technology in the Japanese industry; 1999 nendo sangyo gijutsu rekishi keisho chosa hokokusho. Kokunai sangyo no kikai gijutsu no dokusosei to sozosei no chosa hen



    Fifty years after the Second World War, Japan became the first runner in the R and D of industrial technology in the world. For the purpose of clarifying the course of promotion of the original/creative future R and D and contributing to selection of technical themes and working-out of developmental methods, survey was conducted of persons who conducted epoch-making R and D in machine technology, entrepreneurs of Japan's own and persons who contributed to education of engineers. The FY 1999 results were reported. In this fiscal year, the detailed survey of the following eight was conducted in terms of the achievements and the related data: C. D. West, educator of mechanical engineering; Seiichi Tejima, pioneer of industrial education; Yaekichi Sekiguchi, pioneer of machine tool; Saiichiro Uchimaru who devoted himself to writing of engineering books; Chuzaburo Shiba, specialist of ship use engine; Takeo Yamanobe, pioneer engineer in the spinning industry in Japan; Toyota Kiichiro who promoted the automobile industry in Japan; Soichiro Honda who built the world-famous 'Honda.' The paper also surveyed biographies of machine engineers/managers in Japan and made a list of them. (NEDO)

  16. Report on survey in fiscal 2000 on the survey on succession of history of industrial technologies. Survey edition of originality and creativity of industrial machine technologies in Japan; 2000 nendo sangyo gijutsu rekishi keisho chsao hokokusho. Kokunai sangyo kikai gijutsu no dokusosei to sozosei noc hosahen



    In order to clarify the innovation process of industrial technologies in Japan and the originality and creativity seen in the process, the case history has been introduced in relation with the researchers, engineers, and business proprietors having contributed to the innovation, and their work records. With regard to machine tools, detailed introductions were given to 'Toshisuke Takeo' who had the technological concept learned in the United States, and devoted himself in building modern machine tools, an American, 'Willian R. Gorham', who had worked actively in Japan even during the war, 'Hiroshi Hanaoka' who had made a machining center for the first time in Japan, and 'Shinkichi Nagaoka' a developer of the non-circular flat bearing. In the railway area, 'Richard Francis Trevithick' and 'Francis Henry Trevithick' , leaders of the rolling stock manufacturing technologies, 'Yasujiro Shima' who had contributed to building the foundation of the Japan's rolling stock technologies, 'Kiichi Asakura' who had contributed to establishment of the Japan's rolling stock technologies and industry standardization, and 'Hideo Shima' who had borne fruit of systematization of the Japan's railway technologies by building the Shinkansen were introduced in detail. (NEDO)

  17. Voices from the front lines. Four leaders on the cross-border challeng they've faced.

    Minguet, Luc; Caride, Eduardo; Yamaguchi, Takeo; Tedjarati, Shane


    Executives on the front lines of managing across borders share their insights: Luc Minguet, of France's Michelin, talks about the importance of cultural training not just for managers taking on assignments abroad but also for local employees who work with colleagues from around the world. He describes how his own experience learning to communicate across cultures reflects the tire-maker's broader practices. Eduardo Caride, of Madrid-based Telefónica, explains how the relatively young multinational is investing in a diverse talent mix as it strives to become a truly global company. Whereas early on, leaders relied on exporting Spanish managers abroad, he notes, the street now runs both ways. Takeo Yamaguchi, of Japan's Hitachi, details his efforts to create standardized global HR systems and processes across the conglomerate's 948 separate companies. "Three years ago, we had no systematic way of tracking employees, evaluating performance, or identifying future leaders," Yamaguchi says. "Today we do." And Shane Tedjarati, from the United States' Honeywell, talks about how the industrial powerhouse is shifting its strategy toward new regions, such as China, India, vietnam, and Indonesia. "We call these markets 'high-growth regions' instead of emerging markets," says Tedjarati, "because they now account for more than half of Honeywell's total growth."

  18. COBALT: Development of a Platform to Flight Test Lander GN&C Technologies on Suborbital Rockets

    Carson, John M., III; Seubert, Carl R.; Amzajerdian, Farzin; Bergh, Chuck; Kourchians, Ara; Restrepo, Carolina I.; Villapando, Carlos Y.; O'Neal, Travis V.; Robertson, Edward A.; Pierrottet, Diego; hide


    The NASA COBALT Project (CoOperative Blending of Autonomous Landing Technologies) is developing and integrating new precision-landing Guidance, Navigation and Control (GN&C) technologies, along with developing a terrestrial fight-test platform for Technology Readiness Level (TRL) maturation. The current technologies include a third- generation Navigation Doppler Lidar (NDL) sensor for ultra-precise velocity and line- of-site (LOS) range measurements, and the Lander Vision System (LVS) that provides passive-optical Terrain Relative Navigation (TRN) estimates of map-relative position. The COBALT platform is self contained and includes the NDL and LVS sensors, blending filter, a custom compute element, power unit, and communication system. The platform incorporates a structural frame that has been designed to integrate with the payload frame onboard the new Masten Xodiac vertical take-o, vertical landing (VTVL) terrestrial rocket vehicle. Ground integration and testing is underway, and terrestrial fight testing onboard Xodiac is planned for 2017 with two flight campaigns: one open-loop and one closed-loop.

  19. Accelerated killing of cancer cells using a multifunctional single-walled carbon nanotube-based system for targeted drug delivery in combination with photothermal therapy

    Jeyamohan P


    Full Text Available Prashanti Jeyamohan, Takashi Hasumura, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D Sakthi Kumar Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan Abstract: The photothermal effect of single-walled carbon nanotubes (SWCNTs in combination with the anticancer drug doxorubicin (DOX for targeting and accelerated destruction of breast cancer cells is demonstrated in this paper. A targeted drug-delivery system was developed for selective killing of breast cancer cells with polyethylene glycol biofunctionalized and DOX-loaded SWCNTs conjugated with folic acid. In our work, in vitro drug-release studies showed that the drug (DOX binds at physiological pH (pH 7.4 and is released only at a lower pH, ie, lysosomal pH (pH 4.0, which is the characteristic pH of the tumor environment. A sustained release of DOX from the SWCNTs was observed for a period of 3 days. SWCNTs have strong optical absorbance in the near-infrared (NIR region. In this special spectral window, biological systems are highly transparent. Our study reports that under laser irradiation at 800 nm, SWCNTs exhibited strong light–heat transfer characteristics. These optical properties of SWCNTs open the way for selective photothermal ablation in cancer therapy. It was also observed that internalization and uptake of folate-conjugated NTs into cancer cells was achieved by a receptor-mediated endocytosis mechanism. Results of the in vitro experiments show that laser was effective in destroying the cancer cells, while sparing the normal cells. When the above laser effect was combined with DOX-conjugated SWCNTs, we found enhanced and accelerated killing of breast cancer cells. Thus, this nanodrug-delivery system, consisting of laser, drug, and SWCNTs, looks to be a promising selective modality with high treatment efficacy and low side effects for cancer therapy. Keywords: cancer, nanotherapy, SWCNTs, targeted drug delivery

  20. Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval

    Iwase H


    Full Text Available Yutaka Yamamoto1, Ichiro Kawano2, Hirotaka Iwase11Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; 2Department of Surgery, Asahino General Hospital, Kumamoto, JapanAbstract: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel is a novel formulation of paclitaxel that does not require solvents such as polyoxyethylated castor oil and ethanol. Use of these solvents has been associated with toxic response, including hypersensitivity reactions and prolonged sensory neuropathy, as well as a negative impact in relation to the therapeutic index of paclitaxel. nab-paclitaxel displays greater antitumor activity and less toxicity than solvent-base paclitaxel. In a phase I trial of single nab-paclitaxel, the maximum tolerated dose was 300 mg/m2 with the dose limiting toxicities being sensory neuropathy, stomatitis, and superficial keratopathy. In the metastatic setting, a pivotal comparative randomized phase III study demonstrated that nab-paclitaxel (at 260 mg/m2 over 30 minutes infusion without premedication every 3 weeks mediated a superior objective response rate and prolonged time to progression compared with solvent-based paclitaxel (at 175 mg/m2 over a 3-hour injection with standard premedication. The nab-paclitaxel-treated group showed a higher incidence of sensory neuropathy than the solvent-based paclitaxel group. However, these adverse side effects rapidly resolved after interruption of treatment and dose reduction. Weekly administration of nab-paclitaxel was also more active and displayed less toxicity compared with 100 mg/m2 docetaxel given triweekly. Nab-paclitaxel has already been approved in 42 countries for the treatment of metastatic breast cancer previously treated with anthracycline, based on confirmation of the efficacy and manageable toxicity in the metastatic setting. This review summarizes the most relevant knowledge on nab-paclitaxel for treating breast cancer

  1. Survey on lower urinary tract symptoms and sleep disorders in patients treated at urology departments

    Shimizu N


    Full Text Available Nobutaka Shimizu,1 Yasuharu Nagai,1 Yutaka Yamamoto,1 Takafumi Minami,1 Taiji Hayashi,1 Hidenori Tsuji,1 Masahiro Nozawa,1 Kazuhiro Yoshimura,1 Tokumi Ishii,1 Hirotsugu Uemura,1 Takashi Oki,2 Koichi Sugimoto,2 Kazuhiro Nose,2 Tsukasa Nishioka21Department of Urology, Kinki University Faculty of Medicine, Osaka, Japan; 2Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, JapanObjectives: This study examined the association between sleep disorders and lower urinary tract symptoms in patients who had visited urology departments.Methods: This was an independent cross-sectional, observational study. Outpatients who had visited the urology departments at the Kinki University School of Medicine or the Sakai Hospital, Kinki University School of Medicine, between August 2011 and January 2012 were assessed using the Athens Insomnia Scale and the International Prostate Symptom Score.Results: In total, 1174 patients (mean age, 65.7 ± 13.7 years, with 895 men (67.1 ± 13.2 years old and 279 women (61.4 ± 14.6 years old, were included in the study. Approximately half of these patients were suspected of having a sleep disorder. With regard to the International Prostate Symptom Score subscores, a significant increase in the risk for suspected sleep disorders was observed among patients with a post-micturition symptom (the feeling of incomplete emptying subscore of ≥1 (a 2.3-fold increase, a storage symptom (daytime frequency + urgency + nocturia subscore of ≥5 (a 2.7-fold increase, a voiding symptom (intermittency + slow stream + hesitancy subscore of ≥2 (a 2.6-fold increase, and a nocturia subscore of ≥2 (a 1.9-fold increase.Conclusion: The results demonstrated that the risk factors for sleep disorders could also include voiding, post-micturition, and storage symptoms, in addition to nocturia.Keywords: lower urinary tract symptoms, sleep disturbance, urological disease

  2. Composite model to reproduce the mechanical behaviour of methane hydrate bearing soils

    De la Fuente, Maria


    Methane hydrate bearing sediments (MHBS) are naturally-occurring materials containing different components in the pores that may suffer phase changes under relative small temperature and pressure variations for conditions typically prevailing a few hundreds of meters below sea level. Their modelling needs to account for heat and mass balance equations of the different components, and several strategies already exist to combine them (e.g., Rutqvist & Moridis, 2009; Sánchez et al. 2014). These equations have to be completed by restrictions and constitutive laws reproducing the phenomenology of heat and fluid flows, phase change conditions and mechanical response. While the formulation of the non-mechanical laws generally includes explicitly the mass fraction of methane in each phase, which allows for a natural update of parameters during phase changes, mechanical laws are, in most cases, stated for the whole solid skeleton (Uchida et al., 2012; Soga et al. 2006). In this paper, a mechanical model is proposed to cope with the response of MHBS. It is based on a composite approach that allows defining the thermo-hydro-mechanical response of mineral skeleton and solid hydrates independently. The global stress-strain-temperature response of the solid phase (grains + hydrate) is then obtained by combining both responses according to energy principle following the work by Pinyol et al. (2007). In this way, dissociation of MH can be assessed on the basis of the stress state and temperature prevailing locally within the hydrate component. Besides, its structuring effect is naturally accounted for by the model according to patterns of MH inclusions within soil pores. This paper describes the fundamental hypothesis behind the model and its formulation. Its performance is assessed by comparison with laboratory data presented in the literature. An analysis of MHBS response to several stress-temperature paths representing potential field cases is finally presented. References

  3. 我国海域常见有毒水母的分类检索%Taxonomy Key of the Venomous Jellyfishes in China Sea

    刘萍; 张学雷; 宋洪军; 庞敏


    综合现有资料编制了我国海域常见的19种有毒水母种类的分类检索表.我国常见有毒水母分属于3纲8目14科17属,包括水螅水母类3种、管水母类2种、立方水母类2种、钵水母类12种,其中钵水母纲旗口水母目和根口水母目种类较多(各5种),其它目每目含1~2科且每科仅1属1种.对我国现有的水母分类体系中部分与国际通用体系不统一之处进行了厘正,如:火水母拉丁文种名应由Tamoya alata Uchida,1929厘正为Tamoya gargantua Haeckel,1880,建议将灯罩水母[Linuche draco (Haeckel,1880)]命名厘正为爪罩水母[Linuche unguiculata (Schwartz,1788)]等.%A taxonomy key for 19 species of common venomous jellyfishes in China sea was constructed based on the morphologic characteristics of different classes,orders,families,genera and species.There were 3 hydromedusa,2 siphonophore,2 cubomedusae and 12 scyphomedusae.More species belonged to the orders Semaeostomeae (5 species) and Rhizostomeae (5 species) of class Scyphozoa,and fewer (1 or 2 species) per the other orders.Some inconsistency of jellyfish taxonomy being used in China was detected and clarified,e.g.the abandoned name of Tamoya alata (Uchida,1829) should be replaced with Tamoya gargantua (Haeckel,1880),and the name of Linuchedraco (Haeckel,1880) was suggested to be replaced with the currently accepted name Linuche unguiculata (Schwartz,1788) following WoRMS (World Register of Marine Species).

  4. Preliminary analysis of seismic anisotropy in the uppermost mantle beneath NW Pacific reveled by the Normal Oceanic Mantle project

    Takeo, A.; Isse, T.; Nishida, K.; Kawakatsu, H.; Shiobara, H.; Sugioka, H.; Ito, A.; Utada, H.


    Seismic structure including anisotropy in the oceanic uppermost mantle is essential for understanding deformation related to plate tectonics. Recent reports of a sharp discontinuity between the high velocity LID and the low velocity zone (LVZ) especially emphasize the importance of observation in oceanic basins apart from ridges and hotspots for determining the structure including LID and LVZ. In this study, we analyzed records of four broadband ocean bottom seismometers (BBOBSs) deployed in the northwest of Shatsky Rise by the pilot observation of the Normal Oceanic Mantle (NOMan) project in 2010-2011. We first measured average phase velocities of surface waves at periods of 5-30 s by the ambient-noise cross correlation method. Based on the method of Takeo et al. (in prep. GJI), we analyzed fundamental- and first higher- mode Rayleigh waves and fundamental-mode Love wave simultaneously by waveform fitting after the correction of clock delay. At periods of 25-100 s, we measured phase velocities of fundamental-mode surface waves by the array analysis of teleseismic waveforms. We then determined one-dimensional radially anisotropic structure beneath the array by the method of Takeo et al. (2013, JGR). The obtained structure shows transition from LID to LVZ at depths of 50-80km, which is marginally consistent with the depth of ~80 km estimated by a receiver function analysis at WP2 station situated at east of the studies area (Kawakatsu et al., 2009). The velocity gradient in the LID is almost zero and inconsistent with the simple cooling model of homogeneous oceanic plate. The average intensity of S-wave radial anisotropy at depths of ~10-220 km is ~3% (VSH>VSV). We further estimated S-wave azimuthal anisotropy at depths of ~30-100 km by analyzing teleseismic fundamental-mode Rayleigh waves at periods of 25-50 s. The intensity of anisotropy is 2-3%. The fastest direction is about N35W, close to that of Sn-wave velocity around WP2 station obtained by a refraction

  5. Focal Mechanism of Semi-Volcanic Deep Low-Frequency Earthquakes in Eastern Shimane

    Aso, N.; Ohta, K.; Ide, S.


    Many deep low-frequency earthquakes (LFEs) occur near the island arc Mohorovicic discontinuities and far from both active volcanoes and plate boundaries. They are quite similar to volcanic LFEs beneath active volcanoes, which infers some fluid movement in the source region, and we regard them as "semi-volcanic" LFEs [Aso et al., 2011; 2012 (submitted)]. Several previous studies determined the focal mechanisms of volcanic and semi-volcanic LFEs using a small portion of information of the waveforms. Although the estimated focal mechanisms are various, they may not necessary support the variety of the actual physical process, owing to the large determination error [e.g., Nishidomi and Takeo, 1996; Ohmi and Obara, 2002; Nakamichi et al., 2003]. Here we determine the focal mechanisms by waveform inversion for LFEs in eastern Shimane in western Japan, where many LFEs occurred in a quiet region. The locations are also close to the fault plane of the 2000 western Tottori earthquake of Mw6.6, and right beneath Yokota volcano, which is a Quaternary volcanic cluster. We estimated the focal mechanisms of semi-volcanic LFEs in eastern Shimane by moment tensor inversion. The data are velocity seismograms at five stations of Hi-net near the epicenters. For each seismogram, we extracted a 1.5-second time window beginning from 0.2 seconds before the arrivals of either P-wave in a vertical component or S-wave in a horizontal component. The arrival time of each phase is picked manually first, and then corrected to minimize the variance between observed and synthetic waveforms. The local site amplification is estimated using far-field body waves from deep intraslab earthquakes, and collected for each seismogram. The synthetic waveforms were calculated using the discrete wavenumber integration method developed by Takeo [1985] for a horizontally layered structure. For 38 LFEs, which are equal to or larger than M1.2 (JMA magnitude) and recorded at all five stations, the focal mechanisms

  6. On the concepts of amae and the mother-group.

    Scheidlinger, S


    Notwithstanding Freud's (1921) early linkage of psychoanalytic group psychology with patriarchal themes (i.e., father-leader), more recent findings suggest that the regression in group behavior in general, and in group psychotherapy in particular, tends to evoke frequent maternal ideations. In this connection, this article points to a phenomenological relationship between the individual's universal need to be at one with the internalized mother, as exemplified in the Japanese concept of amae and that of the Mother-Group. With amae serving as an explanatory construct for the group members' interpersonal relations (i.e., identifications and transferences), the idea of the Mother-Group ties in with the group entity's simultaneous supportive functions (i.e., "we are all in the same boat") coupled with its role as a collective arena for the reactivation of unconscious wishes for the nurturing mother of early childhood. In linking a Japanese psychological concept with another, which was developed in the West, I am disproving Rudyard Kipling's often quoted assertion that "never the East and the West shall meet." I was encouraged in this task by Takeo Doi's written comment to me that the idea of the Mother-Group "certainly can be linked with that of Amae. For instance, when the group functions as the Mother-Group, you can say that the participants are experiencing Amae in one way or another" (T. Doi, Sept. 17, 1993, personal communication). In an extended sense, one hopes this essay might even serve to revive our interest in the interrupted well-known early collaboration of psychoanalysts and of anthropologists, which had begun to forge a way to connect personality formation with its cultural context (LeVine, 1974). The insufficient attention paid to the influence of cultural factors on attachment behavior was recently decried by Bretherton (1997).

  7. Clinical significance of barriers to blood glucose control in type 2 diabetes patients with insufficient glycemic control

    Suzuki T


    Full Text Available Takeo Suzuki,1 Ryoko Takei,2 Toyoshi Inoguchi,2,3 Noriyuki Sonoda,2,3 Shuji Sasaki,2 Toshihiko Kaise,1 Ryoichi Takayanagi21Development and Medical Affairs Division, GlaxoSmithKline K.K., Tokyo, 2Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, 3Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, JapanBackground: The purpose of this study was to assess actual barriers to blood glucose control in patients with type 2 diabetes mellitus and to investigate barrier-related factors in an exploratory manner.Methods: This cross-sectional study assessed patients with type 2 diabetes mellitus treated as outpatients at medical institutions within Fukuoka Prefecture, Japan. Barriers to blood glucose control were examined in patients with glycated hemoglobin ≥6.9% using a nine-item questionnaire. Answers were also obtained from physicians in charge of the patients for seven of nine questions.Results: Seven hundred and thirteen patients answered the questionnaire. Many physicians and patients described barriers that involved difficulty in complying with diet therapy. For six of the seven barriers, patient awareness was lower than physician awareness. Patient-reported lack of concern for diabetes mellitus was more prevalent among patients with macrovascular complications. Patients who reported difficulty in compliance with exercise therapy and fear of hypoglycemia were more likely to suffer from microvascular complications.Conclusion: For many of the barriers to blood glucose control, patients were less aware than physicians, suggesting that we need to take action to raise patient awareness. Of interest are the observations that the relevant barriers differed for macrovascular and microvascular complications and that the relationship between presence of macrovascular complications and lack of concern about diabetes mellitus.Keywords: epidemiology, patient education, patient behavior, patient

  8. Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis: involvement of NF-kappa B and STAT-1 signaling pathways

    Kuninobu Wakabayashi


    Full Text Available Takeo Isozaki, Tsuyoshi Kasama, Ryo Takahashi, Tsuyoshi Odai, Kuninobu Wakabayashi, Hirohito Kanemitsu, Kyoko Nohtomi, Hiroko T Takeuchi, Satoshi Matsukura, Masakazu TezukaDivision of Rheumatology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan, and the Department of Orthopedics, Denencyofu Central Hospital, Tokyo, JapanAbstract: To explore the regulation of CX3CL1 in inflammatory bone diseases, CX3CL1 expression by osteoblasts (OB was examined. Human OB isolated from rheumatoid arthritis (RA patients, osteoarthritis patients, and normal individuals were incubated in the presence of cytokines. Soluble CX3CL1 levels were determined with an enzyme-linked immunosorbent assay. Expression of CX3CL1 mRNA was examined using quantitative real-time polymerase chain reaction. Although tumor necrosis factor (TNF-α or interferon (IFN-γ alone RA OB induced negligible CX3CL1 secretion, the combination of TNF-α and IFN-γ induced dramatic increases in both soluble CX3CL1 protein and mRNA transcripts. This synergistic effect was more pronounced in OB from RA than in OB from either osteoarthritis or normal individuals. The expression of CX3CL1 was markedly reduced by specific inhibitors of the nuclear factor-κB (NF-κB or STAT-1 transcription factor. These findings suggest that osteoblasts are an important cellular source of CX3CL1 and may play roles in inflammatory bone/joint diseases.Keywords: osteoblast, CX3CL1, chemokine, NF-κB, STAT-1

  9. A community-based education trial to improve backyard poultry biosecurity in rural Cambodia.

    Conan, Anne; Ponsich, Aurélia; Luce Goutard, Flavie; Khiev, Ratana; Tarantola, Arnaud; Sorn, San; Vong, Sirenda


    The emergence and spread of Highly Pathogenic Avian Influenza H5N1 has caused substantial poultry-related economic losses and public health concerns in relation to a potential pandemic. While biosecurity measures for commercial poultry industry are of the highest standards, these measures are difficult to implement and often unaffordable for backyard poultry farming, particularly in tropical and low-income settings. We designed a feasible biosecurity intervention to improve flock hygiene in Cambodia, - based on community hygiene, cleaning of poultry flock areas and human and poultry movement control. We conducted a cluster randomized and controlled intervention trial in 18 villages in Takeo province to evaluate improvements in biosecurity-related knowledge and practices. The intervention relied on community involvement and community education using special information dissemination tools. We trained village teams (VT) to assist villagers in implementing the intervention using a cascade training approach, in which a few individuals were trained, who in turn trained a larger group of people. During the 14 month follow up, we conducted observational and interview-based surveys (baseline vs. final surveys, VT supervision visits, monitoring surveys) to assess VTs' motivation, intervention messages dissemination and the implementation of recommended measures. Most of villagers (95%, confidence interval: 87.8-100.0%) in intervention villages received general information about how to raise poultry. Farmers in intervention villages reported to have made more changes (≥1 biosecurity related practice during the study period) compared with that of control villages (70.0% (260/372) vs. 22.6% (85/377), p valuebiosecurity-related practices in intervention villages, overall scores increased significantly (pbiosecurity practices in the community. However, further follow-ups are needed to assess whether practices-related changes persist over a longer period of time.

  10. A call for action on disarmament and population.

    Fukuda, T


    Takeo Fukuda, former prime minister of Japan, opened the 12th session of the InterAction Council in Dresden, Germany, with a speech on June 7, 1994. The council has three priority concerns: world peace and disarmament; global problems of population increase, environmental degradation, resource and energy questions; and the question of activating the world economy. The cold war structure has crumbled, but stockpiled nuclear weapons still pose a threat to the world. Under such a situation, the role of multilateral organizations, particularly the UN, has become increasingly important. The world's political management henceforth should encompass North-South-East-West, the entire world, and multilateral institutions should be further strengthened. Special attention should be paid to the neglected North-South relations. The emergence of the mass-consumption society has generated the era of finite resources and environment. The rapidly increasing global population further complicates this issue. Unless the global problems of population, environment, resources, and energy are alleviated, the future for posterity is dubious. The population of the world is increasing by 100 million each year. It was 1.6 billion at the beginning of this century, but it is expected to increase to 6.4 billion at the end of the century, to 8 billion by the year 2020, and to 10 billion by 2050. Resources, energy, environment, and global population are mutually linked; the problem of balancing the rapidly increasing population and the food supply must be addressed. The hope is that the Food and Agriculture Organization will come up with measures to cope with this problem by forecasting the food supply and demand and population. The InterAction Council will hold its 13th session in Tokyo in 1995.

  11. What health service support do families need for optimal breastfeeding? An in-depth exploration of young infant feeding practices in Cambodia

    Bazzano AN


    Full Text Available Alessandra N Bazzano,1 Richard A Oberhelman,1 Kaitlin Storck Potts,1 Leah D Taub,1 Chivorn Var2 1Department of Global Community Health and Behavioral Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA; 2National Institute of Public Health, Tuol Kork, Phnom Penh, Cambodia Background: Appropriate and timely breastfeeding practices markedly improve lifelong health outcomes for newborns, children, and mothers. Exclusive breastfeeding is reported to be widely practiced in Cambodia, and important progress has been made toward achieving improved child health outcomes, but newborn mortality has been slow to reduce and breastfeeding practices remain suboptimal. Methods: Formative research was conducted in Takeo province, Cambodia to describe the practical, cultural, and social factors underlying current breastfeeding behaviors to inform the design of a newborn survival intervention that may improve breastfeeding. In-depth interviews, observations, a collection of visual media, and focus groups were employed to gather qualitative data. Results: The results revealed knowledge and practice gaps in behavior that likely contribute to breastfeeding barriers, particularly in the areas of infant latch, milk production, feeding frequency, and the use of breast milk substitutes. The predominant theme identified in the research was a dearth of detailed information, advice, and counseling for mothers beyond the message to exclusively breastfeed for 6 months. Conclusion: Future newborn survival interventions and postnatal care counseling in this area must go beyond the exclusive breastfeeding message. To achieve further impact, it will be necessary to disseminate comprehensive and locally appropriate information on breastfeeding and to improve counseling in order to support successful breastfeeding and to contribute to population-level health gains. Keywords: formative research, health education, lactation, behavior change

  12. Revised CDM baseline study on fuel use and manure management at household level

    Buysman, E.; Bryan, S.; Pino, M.


    This report presents the revised study of the original CDM baseline study conducted in 2006. The original study was conducted under the authority of the National Biogas Program (NBP), to study the potential GHG mitigation resulting from the adoption of domestic biodigesters. In the beginning of June 2006, a survey amongst 300 randomly selected households with the technical potential for a biodigester was conducted in the NBP's 6-targeted provinces (Kampong Cham, Svay Rieng, Prey Veng, Kampong Speu, Takeo and Kandal) in southeast Cambodia. The revised baseline study includes two additional provinces, Kampot and Kampong Chhnang. The survey showed that a significant proportion of the households have no access to basic sanitation and often have health problems. They consume mainly wood as cooking fuel and the majority use inefficient cooking stoves. The main lighting fuel is kerosene. The GHG emissions were calculated for each type of Animal Waste Management System (AWMS) and the baseline fuel consumption. The main methodology used is the GS-VER biodigester methodology and the IPCC 2006 guidelines to ex-ante estimate baseline, project and the emission reductions. The GHG emission from wood burning is only considered when it originates from a non-renewable source. The NRB analysis determined a NRB share of 70.7% for both collected and purchased wood. Total GHG emission is calculated by combining AWMS and wood fuels emissions. The annual baseline and project emission was estimated to be respectively 5.38 tCO2eq and 0.46 tCO2eq per average household, the emission reductions (ER) are therefore 4.92 tCO2eq/household/year.

  13. Insight into the molecular and functional diversity of cnidarian neuropeptides.

    Takahashi, Toshio; Takeda, Noriyo


    Cnidarians are the most primitive animals to possess a nervous system. This phylum is composed of the classes Scyphozoa (jellyfish), Cubozoa (box jellyfish), and Hydrozoa (e.g., Hydra, Hydractinia), which make up the subphylum Medusozoa, as well as the class Anthozoa (sea anemones and corals). Neuropeptides have an early evolutionary origin and are already abundant in cnidarians. For example, from the cnidarian Hydra, a key model system for studying the peptides involved in developmental and physiological processes, we identified a wide variety of novel neuropeptides from Hydra magnipapillata (the Hydra Peptide Project). Most of these peptides act directly on muscle cells and induce contraction and relaxation. Some peptides are involved in cell differentiation and morphogenesis. In this review, we describe FMRFamide-like peptides (FLPs), GLWamide-family peptides, and the neuropeptide Hym-355; FPQSFLPRGamide. Several hundred FLPs have been isolated from invertebrate animals such as cnidarians. GLWamide-family peptides function as signaling molecules in muscle contraction, metamorphosis, and settlement in cnidarians. Hym-355; FPQSFLPRGamide enhances neuronal differentiation in Hydra. Recently, GLWamide-family peptides and Hym-355; FPQSFLPRGamide were shown to trigger oocyte maturation and subsequent spawning in the hydrozoan jellyfish Cytaeis uchidae. These findings suggest the importance of these neuropeptides in both developmental and physiological processes.

  14. Physics Colloquium: Theory of the spin wave Seebeck effect in magnetic insulators

    Université de Genève


    Geneva University Physics Department 24, quai Ernest-Ansermet CH-1211 Geneva 4 Lundi 28 février 2011 17h00 - École de Physique, Auditoire Stückelberg Theory of the spin wave Seebeck effect in magnetic insulators Prof. Gerrit Bauer Delft University of Technology The subfield of spin caloritronics addresses the coupling of heat, charge and spin currents in nanostructures. In the center of interest is here the spin Seebeck effect, which was discovered in an iron-nickel alloy. Uchida et al. recently observed the effect also in an electrically insulating Yttrium Iron Garnett (YIG) thin magnetic film. To our knowledge this is the first observation of a Seebeck effect generated by an insulator, implying that the physics is fundamentally different from the conventional Seebeck effect in metals. We explain the experiments by the pumping of a spin current into the detecting contacts by the thermally excited magnetization dynamics. In this talk I will give a brief overview over the state o...

  15. Containment PT Analysis in case of installation of PCCS using CAP Code

    Choo, Yeon Jun; Hong, Soon Joon [Future and Challenge Technology Co., Yongin (Korea, Republic of); Kim, Gon Han; Cheon, Jong [Korea Electric Power Corporation Research Institute, Daejeon (Korea, Republic of)


    The goal of this project is developing of the conceptual design of containment passive cooling system, including PMCCS (Passive Molten Core Cooling System) and furthermore, applying to APR+ and iPOWER reactor finally. Advanced researches on PCCS were carried out by global nuclear industrial companies and the several types of reactor, such as AP1000, ESBWR and VVER, were introduced. Using the different way, these reactor types, however, are devised to mitigate the consequence of LOCA accident and remove the long-term decay heat. To confirm the reliability of PCCS function during an accident progress, experimental proofs and computational evaluations are vital. To evaluate the PCCS performance, CAP code simulation is preliminarily conducted on the ShinKori 3/4 DEDLSB accident. Two condensation models, Uchida and Dehbi's correlation, are tested for the condensation model applied on PCCS condensation tube outside surface. As compared with the existing spray system, it revealed the good performance in terms of containment pressure reduction. On the other hand, re-pressurization with the start of PCCT coolant temperature increment is observed also.

  16. Martensite transformation. ; Recent progress and perspectives. Martensite hentai. ; Saikin no shinpo to tenbo

    Marukawa, K. (Hokkaido Inst. of Technology, Hokkaido (Japan))


    A seminar was held at Engineering Dept., Hokkaido Univ. in July, 1991 about martensite transformation. The lectures on the seminar are as follows: Bainite transformation in Cu-Zn-Al and Ag-An alloys'' (K. Kitazawa, Hokkaido Univ.) Overviews of the rate of transformation in these alloys, the experimental result of electron microscope observations, and examination on the transformation mechanism. Mechanism model of bainite transformation'' (K. Marukawa, Hokkaido Univ.) Results of experiments on bainite transformation in copper alloys. Dislocation texture and characteristics of iron-system shape memory alloy'' (Y. Inagaki et al, Steel Lab., NKK) The relation between the dislocation texture and storing characteristic of a newly developed shape memory alloy of stainless steel. Bainite texture and transformation mechanism of steel'' (M. Maki, Kyoto Univ.) Experimental data about Fe-M-C alloys. High-strength high-ductile steel plate utilizing retained austenite'' (N. Uchida et al, Nippon Steel Corp.)

  17. Effects of transgenic Cry1A+CpTI cotton and Cry1Ac toxin on the parasitoid, Campoketis chlorideae (Hymenoptera:Ichneumonidae)



    The effect oftransgenic double genes, Cry1A + CpTlcotton and Cry1Ac toxin on the parasitoid, Carnpoketis chlorideae Uchida of cotton bollworm, Helicoverpa armigera (Hübner), was investigated in the laboratory. Helicoverpa armigera larvae when in the first,second and third instar could not survive if fed on transgenic cotton leaves. Consequently,C. chlorideae larvae could not complete their development if parasitizing on such hosts.After H. armigera larvae were reared on transgenic or traditional cotton leaves for 12-48 hours, they were parasitized by C. chlorideae females. Parasitized larvae continued to feed on transgenic or traditional cotton for 12-48 h. The present results showed that the body weight of larvae of the parasitoids were significantly reduced when parasitized hosts fed on transgenic cotton leaves compared to those fed on traditional cotton. Duration of egg and larvae stage were significantly prolonged, pupal and adult weight of C. chloridae was decreased when the host larvae fed on transgenic cotton leaves longer than 48 h. The development duration of C. chlorideae pupae on the hosts fed on transgenic cotton leaves in each treatment was not significantly different from those of controls. The longevity of parasitoid females and males fed with a solution containing Cry1Ac toxin was not significantly different with that of the control.

  18. Review Essay: Governmentality in Late Colonial Korea?

    Henry Em


    Full Text Available Takashi Fujitani, Race for Empire: Koreans as Japanese and Japanese as Americans during World War II. Berkeley: University of California Press, 2011. 520 pp. $65 (cloth.Jun Uchida, Brokers of Empire: Japanese Settler Colonialism in Korea, 1876-1945. Cambridge, MA: Harvard University Press, 2011. 500 pp. $50 (cloth.In South Korea, more so than in most other postcolonial countries, the issue of sovereignty and the colonial past remains a central feature of politics. Most recently, during a televised presidential debate on December 4, 2012, Lee Jung-hee of the Unified Progressive Party said something that likely had never been said on South Korean television: “Takaki Masao signed an oath of loyalty [to the Emperor of Japan], in his own blood, to become an officer in the Japanese [Imperial] Army. You know who he is. His Korean name is Park Chung Hee.” Lee Jung-hee then made the connection between that colonial past and the willingness to sell out the nation’s sovereignty in the present. The conservative candidate Park Geun-hye, the daughter of the late President Park Chung Hee who ruled South Korea from 1961 through 1979, and members of Park’s Saenuri Party, remain true to their “roots”: these “descendants of pro-Japanese collaborators and dictators” (again sold out South Korea’s sovereignty (on November 22, 2011 when they rammed the US-ROK Free Trade Agreement through the National Assembly.

  19. Development of readout system for FE-I4 pixel module using SiTCP

    Teoh, J. J.; Hanagaki, K.; Ikegami, Y.; Takubo, Y.; Terada, S.; Unno, Y.


    The ATLAS pixel detector will be replaced in the future High Luminosity-Large Hadron Collider (HL-LHC) upgrade to preserve or improve the detector performance at high luminosity environment. To meet the tight requirements of the upgrade, a new pixel Front-End (FE) Integrated Circuit (IC) called FE-I4 has been developed. We have then devised a readout system for the new FE IC. Our system incorporates Silicon Transmission Control Protocol (SiTCP) technology (Uchida, 2008 [1]) which utilizes the standard TCP/IP and UDP communication protocols. This technology allows direct data access and transfer between a readout hardware chain and PC via a high speed Ethernet. In addition, the communication protocols are small enough to be implemented in a single Field-Programable Gate Array (FPGA). Relying on this technology, we have been able to construct a very compact, versatile and fast readout system. We have developed a firmware and software together with the readout hardware chain. We also have established basic functionalities for reading out FE-I4.

  20. Potential of trap crops for integrated management of the tropical armyworm, Spodoptera litura in tobacco.

    Zhou, Zhongshi; Chen, Zepeng; Xu, Zaifu


    The tropical armyworm, Spodoptera litura (F.) (Lepidoptera: Noctuidae), is an important pest of tobacco, Nicotiana tabacum L. (Solanales: Solanaceae), in South China that is becoming increasingly resistant to pesticides. Six potential trap crops were evaluated to control S. litura on tobacco. Castor bean, Ricinus communis L. (Malpighiales: Euphorbiaceae), and taro, Colocasia esculenta (L.) Schott (Alismatales: Araceae), hosted significantly more S. litura than peanut, Arachis hypogaea L. (Fabales: Fabaceae), sweet potato, Ipomoea batata Lam. (Solanales: Convolvulaceae) or tobacoo in a greenhouse trial, and tobacco field plots with taro rows hosted significantly fewer S. litura than those with rows of other trap crops or without trap crops, provided the taro was in a fast-growing stage. When these crops were grown along with eggplant, Solanum melongena L. (Solanales: Solanaceae), and soybean, Glycines max L. (Fabales: Fabaceae), in separate plots in a randomized matrix, tobacco plots hosted more S. litura than the other crop plots early in the season, but late in the season, taro plots hosted significantly more S. litura than tobacco, soybean, sweet potato, peanut or eggplant plots. In addition, higher rates of S. litura parasitism by Microplitis prodeniae Rao and Chandry (Hymenoptera: Bracondidae) and Campoletis chlorideae Uchida (Ichnumonidae) were observed in taro plots compared to other crop plots. Although taro was an effective trap crop for managing S. litura on tobacco, it did not attract S. litura in the seedling stage, indicating that taro should either be planted 20-30 days before tobacco, or alternative control methods should be employed during the seedling stage.

  1. Changes in the airway lumen and surrounding parenchyma in chronic obstructive pulmonary disease

    Kurashima K


    Full Text Available Kazuyoshi Kurashima,1 Toshiko Hoshi,2 Yotaro Takaku,1 Tetsu Kanauchi,2 Keitaro Nakamoto,1 Miyuki Ueda,2 Noboru Takayanagi,1 Thomas V Colby,4 Yutaka Sugita,1 Yoshinori Kawabata3 1Department of Respiratory Medicine, 2Department of Radiology, 3Department of Pathology, Saitama Cardiovascular and Respiratory Center, Kumagaya City, Saitama, Japan; 4Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA Background: The purpose of this study was to examine changes in the airway lumen and parenchyma in relation to lung function in patients with chronic obstructive pulmonary disease (COPD compared with controls. Methods: We studied 70 patients with COPD and 15 normal subjects. Using reconstructed computed tomography (CT images, we traced the bronchial trees and reconstructed 3 cm circle images around the airways exactly perpendicular to the airway axis at the peripheral, middle, and central zones of the bronchi. We measured the number of airways and vessels, the airway inner diameter, and the area of emphysema in the circles, and analyzed the relationship of these image parameters to lung function. Results: Reduced airway numbers and increased upper lobe emphysema were observed even in early spirometric stages in patients with COPD compared with controls. Other findings included decreased airway inner diameter in advanced spirometric stages. The numbers of peripheral zone bronchi, the extent of the middle zone emphysematous area, and the mean airway inner diameter of the airways were the best predictors of spirometric parameters. A portion of the airways in patients with COPD showed a loss of airway patency at middle or central zone bronchi predominantly in the late spirometric stages. Lumen-obliterated bronchial trees could be traced into emphysematous areas showing air trapping. Conclusion: Compared with controls, our CT observations in patients with COPD showed that airway lumen and lung parenchyma changes along airways

  2. Burden of menstrual symptoms in Japanese women – an analysis of medical care-seeking behavior from a survey-based study

    Tanaka E


    Full Text Available Erika Tanaka,1 Mikio Momoeda,2 Yutaka Osuga,3 Bruno Rossi,4 Ken Nomoto,5 Masakane Hayakawa,5 Kinya Kokubo,6 Edward CY Wang1 1Health Economics and Outcomes Research, Bayer Yakuhin Ltd, Tokyo, Japan; 2Department of Integrated Women's Health, St Luke's International Hospital, Tokyo, Japan; 3Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan; 4Market Access, Bayer Yakuhin Ltd, Osaka, Japan; 5Medical Affairs Women's Health and Dermatology, Bayer Yakuhin Ltd, Osaka, Japan; 6Consumer Goods/Service and Healthcare Industry Consulting Department, Nomura Research Institute, Tokyo, Japan Background: Menstrual symptoms are associated with various health problems in women of reproductive age, and this may impact their quality of life. Despite this, Japanese women are likely to hesitate seeking a specialist's medical help for their menstrual symptoms. Purpose: To study subject parameters including symptom severity, gynecological disorders, and treatments in medical care-seeking women (outpatient and women opting for self-care (nonvisit, to identify reasons why Japanese women do not see a gynecologist, and to document the benefit of gynecologist visits by assessing the impact on women's daily lives. Methods: Two online surveys were conducted among women aged 15–49 years. Sampling was structured to approximate the age and geographic distribution in Japan. Results of the first survey and part of the second survey on the overall current burden of menstrual symptoms are reported in a separate publication. Further outcomes from the second survey reported in this paper included data from the outpatient (n=274 and nonvisit (n=500 groups on symptom severity, gynecological disorders, medical treatment use, reasons for not seeking medical care, and the improvement of daily life. Results: The outpatient group tended to have greater symptom severity compared to the nonvisit group. Uterine fibroids, dysmenorrhea

  3. Activated protein C modulates the proinflammatory activity of dendritic cells

    Matsumoto T


    Full Text Available Takahiro Matsumoto,1,2* Yuki Matsushima,1* Masaaki Toda,1 Ziaurahman Roeen,1 Corina N D'Alessandro-Gabazza,1,5 Josephine A Hinneh,1 Etsuko Harada,1,3 Taro Yasuma,4 Yutaka Yano,4 Masahito Urawa,1,5 Tetsu Kobayashi,5 Osamu Taguchi,5 Esteban C Gabazza1 1Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie Prefecture, 2BONAC Corporation, BIO Factory 4F, Fukuoka, 3Iwade Research Institute of Mycology, 4Department of Endocrinology, Diabetes and Metabolism, 5Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie Prefecture, Japan *These authors contributed equally to this work Background: Previous studies have demonstrated the beneficial activity of activated protein C in allergic diseases including bronchial asthma and rhinitis. However, the exact mechanism of action of activated protein C in allergies is unclear. In this study, we hypothesized that pharmacological doses of activated protein C can modulate allergic inflammation by inhibiting dendritic cells. Materials and methods: Dendritic cells were prepared using murine bone marrow progenitor cells and human peripheral monocytes. Bronchial asthma was induced in mice that received intratracheal instillation of ovalbumin-pulsed dendritic cells. Results: Activated protein C significantly increased the differentiation of tolerogenic plasmacytoid dendritic cells and the secretion of type I interferons, but it significantly reduced lipopolysaccharide-mediated maturation and the secretion of inflammatory cytokines in myeloid dendritic cells. Activated protein C also inhibited maturation and the secretion of inflammatory cytokines in monocyte-derived dendritic cells. Activated protein C-treated dendritic cells were less effective when differentiating naïve CD4 T-cells from Th1 or Th2 cells, and the cellular effect of activated protein C was mediated by its receptors. Mice that received adoptive transfer of activated protein C

  4. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain – a pilot study of gait analysis

    Kanzaki N


    Full Text Available Noriyuki Kanzaki,1 Yuta Otsuka,1 Takayuki Izumo,1 Hiroshi Shibata,1 Hideyuki Nagao,2 Keita Ogawara,3 Hiroshi Yamada,3 Seiji Miyazaki,3 Yutaka Nakamura3 1Institute for Health Care Science, Suntory Wellness Ltd, Seika-cho, Soraku-gun, Kyoto, Japan; 2Research Institute of Sports Medical Science, Tokai University, Hiratsuka, Kanagawa, Japan; 3School of Physical Education, Tokai University, Hiratsuka, Kanagawa, Japan Background: Previously, we demonstrated that glucosamine-containing supplementation was effective for improving locomotor functions, especially walking speed. However, the biomechanical mechanism of efficacy has not been elucidated. This study aimed to address this challenge in subjects with knee pain, using a motion capture system. Methods: An open label study was conducted in 30 Japanese subjects with knee pain. The subjects were administered a daily supplement containing 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, 1 mg of proteoglycan, and 5 µg of vitamin D (GCQID. The intervention continued for 16 weeks. Efficacy for locomotor functions involving the knee joint was evaluated mainly using the Japanese Knee Osteoarthritis Measure (JKOM and the 5-question Geriatric Locomotive Function Scale (GLFS-5. To examine the biomechanical mechanism of efficacy for locomotor functions, motions of subjects in a normal walking state were captured. Gait analysis was conducted and efficacy for gait parameters such as normal walking speed, stride length, cadence, and angle of soles was evaluated. Results: GCQID significantly improved total scores on the JKOM and GLFS-5. In gait analysis, normal walking speed, stride length, and angle of soles at the end of the stance phase were all significantly increased, but cadence did not change significantly during the intervention period. There were significant intercorrelations of changes in

  5. Experimental Urban Heat Island Research of Four Biggest Polar Cities in Northern Hemisphere

    Konstantinov, Pavel; Baklanov, Alexander; Varentsov, Mikhail; Kukanova, Evgenia; Repina, Irina; Shuvalov, Sergey; Samsonov, Timofey


    Fairbanks, Alaska// Theor. Appl. Climatol. 1999. V. 64, pp 39-47 2. Ohashi, Yukitaka, Yutaka Genchi, Hiroaki Kondo, Yukihiro Kikegawa, Hiroshi Yoshikado, Yujiro Hirano, 2007: Influence of Air-Conditioning Waste Heat on Air Temperature in Tokyo during Summer: Numerical Experiments Using an Urban Canopy Model Coupled with a Building Energy Model.J. Appl. Meteor. Climatol., 46, 66-81. 3. Oke, Timothy R. Boundary layer climates - 2nd ed. Publisher, London: Routledge. 1987

  6. Evaluation of an advanced pressure ulcer management protocol followed by trained wound, ostomy, and continence nurses: a non-randomized controlled trial

    Kaitani T


    Full Text Available Toshiko Kaitani,1 Gojiro Nakagami,2 Junko Sugama,3 Masahiro Tachi,4 Yutaka Matsuyama,5 Yoshiki Miyachi,6 Takashi Nagase,2 Yukie Takemura,7 Hiromi Sanada2 1School of Nursing, Sapporo City University, Hokkaido, Japan; 2Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 3Department of Clinical Nursing, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; 4Department of Plastic Surgery, Tohoku University Graduate School of Medicine, Miyagi, Japan; 5Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 6Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; 7Department of Nursing, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Aims and objectives: We investigated the effectiveness and safety of an advanced pressure ulcer (PU management protocol comprising 1 ultrasonography to assess the deep tissue, 2 use of a non-contact thermometer to detect critical colonization, 3 conservative sharp debridement, 4 dressing selection, 5 negative pressure wound therapy, and 6 vibration therapy in comparison with those of a conventional approach. Each protocol was followed by trained wound, ostomy, and continence nurses (WOCNs. Background: At present, there is no systematic PU management protocol for nurses that includes appropriate assessment and intervention techniques for deep tissue injury and critical colonization. In Japan, there is no such protocol that the nurses can follow without a physician’s orders. Design and methods: This was a prospective non-randomized controlled trial. Over a 3-week period, we evaluated the effectiveness of an advanced protocol by comparing the PU severity and healing on the basis of the DESIGN-R scale and presence of patients' discomfort. We recruited ten WOCNs to follow

  7. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Mori Y


    Full Text Available Yutaka Mori,1,2 Shizuka Aritomi,3 Kazumi Niinuma,3 Tarou Nakamura,3 Kenichi Matsuura,1 Junichi Yokoyama,1 Kazunori Utsunomiya1 1Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Japan; 2Department of Clinical Research, National Hospital Organization, Utsunomiya National Hospital, Utsunomiya, Japan; 3Research Center, Ajinomoto Pharmaceuticals Co, Ltd, Kanagawa, Japan Abstract: Cilnidipine (Cil, which is an L-/N-type calcium channel blocker (CCB, has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS and the renin–angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml, which is an L-type CCB, with an angiotensin (Ang II receptor blocker on diabetic cardiorenal damage in spontaneously type 2 diabetic rats. Seventeen-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to receive Cil, Aml, valsartan (Val, Cil + Val, Aml + Val, or a vehicle (eight rats per group for 22 weeks. Antihypertensive potencies were nearly equal among the CCB monotherapy groups and the combination therapy groups. The lowering of blood pressure by either treatment did not significantly affect the glycemic variables. However, exacerbations of renal and heart failure were significantly suppressed in rats administered Cil or Val, and additional suppression was observed in those administered Cil + Val. Although Val increased the renin–Ang system, Aml + Val treatment resulted in additional increases in these parameters, while Cil + Val did not show such effects. Furthermore, Cil increased the ratio of Ang-(1–7 to Ang-I, despite the fact that Val and Aml + Val decreased the Ang-(1–7 levels. These actions of Cil + Val might be due to their synergistic inhibitory effect on the activity of the SNS, and on aldosterone secretion through N-type calcium channel antagonism and Ang II

  8. Human epidermal growth factor receptor-2 overexpression and amplification in metastatic and recurrent high grade or type 2 endometrial carcinomas

    Kato R


    Full Text Available Rina Kato,1 Kiyoshi Hasegawa,1 Risa Ishii,1 Akiko Owaki,1 Yutaka Torii,1 Shuko Oe,1 Hiroshi Hirasawa,2 Yoichi Kobayashi,3 Yasuhiro Udagawa1 1Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; 2Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan; 3Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Japan Introduction: Human epidermal growth factor receptor (HER-2 overexpression or gene amplification is more common in high-grade or type 2 endometrial carcinomas. We assessed the discordance of HER-2 expression between primary and metastatic or recurrent endometrial carcinomas. Materials and methods: Thirty-six primary, along with 14 metastatic and five recurrent tumors (matched to primaries, pathologically confirmed as high-grade or type 2 endometrial carcinomas, were submitted for immunohistochemistry (IHC for HER-2. Fluorescence in situ hybridization was performed when the tumors showed HER-2 overexpression (≥2+ IHC score. The results of the IHC and fluorescence in situ hybridization assays were compared between the primary and metastatic or recurrent tumors. The relationships between HER-2 expression and clinicopathological factors or prognosis were investigated. Results: HER-2 overexpression and HER-2 amplification (a ratio of HER-2 copies to chromosome 17 [CEP17] copies ≥2.2 were detected in 33.3% (twelve of 36 patients and 5.6% (two of 36 patients of primary tumors, respectively. HER-2 overexpression was not associated with clinicopathological factors or prognosis. In 19 tumor specimens obtained from metastatic or recurrent tumors, HER-2 overexpression and HER-2 amplification were detected in 57.9% (eleven patients and 15.8% (three patients, respectively. HER-2 overexpression tended to predict a worse prognosis. Conclusion: HER-2 expression in metastatic or recurrent tumors was more frequent than in matched primary high

  9. Therapeutic efficacy and anti-inflammatory effect of ramelteon in patients with insomnia associated with lower urinary tract symptoms

    Shimizu N


    Full Text Available Nobutaka Shimizu,1 Masahiro Nozawa,1 Koichi Sugimoto,2 Yutaka Yamamoto,1 Takafumi Minami,1 Taiji Hayashi,1 Kazuhiro Yoshimura,1 Tokumi Ishii,1 Hirotsugu Uemura11Department of Urology, Faculty of Medicine, Kinki University, Osaka, 2Department of Urology, Sakai Hospital, Faculty of Medicine, Kinki University, Osaka, JapanObjectives: This study was conducted to examine the therapeutic efficacy and anti-inflammatory effect of ramelteon in elderly patients with insomnia associated with lower urinary tract symptoms (LUTS, who visited our urology department.Methods: The study included 115 patients (102 men, 13 women who scored ≥4 on the Athens Insomnia Scale and who wished to receive treatment. The assessment scales for therapeutic efficacy included the International Prostate Symptom Score (IPSS for LUTS and the Insomnia Severity Index (ISI for sleep disorders. The high-sensitivity C-reactive protein (hs-CRP test was used to an objective assessment. The patients were treated with ramelteon (8 mg/day for an average of 10 weeks and were then reexamined using the questionnaires and hs-CRP test to evaluate therapeutic efficacy.Results: IPSS total scores declined significantly from 11.39 ± 8.78 to 9.4 ± 7.72. ISI total scores improved significantly from 11.6 ± 5.2 to 9.2 ± 5.3 (P < 0.0001. The levels of hs-CRP decreased significantly from 0.082 (standard deviation [SD] upper limit, 0.222; SD lower limit, −0.059 to 0.06 (SD upper limit, 0.152; SD lower limit, −0.032. The ISI scores ≥ 10 (n = 51 showed a weak correlation with the hs-CRP levels.Conclusion: Ramelteon had a systemic anti-inflammatory effect and improved sleep disorders and LUTS, suggesting that it may be a useful treatment for patients with LUTS-associated insomnia.Keywords: sleep disorders, inflammation, lower urinary tract symptoms, ramelteon

  10. Application of the homology method for quantification of low-attenuation lung region in patients with and without COPD

    Nishio M


    Full Text Available Mizuho Nishio,1 Kazuaki Nakane,2 Yutaka Tanaka3 1Clinical PET Center, Institute of Biomedical Research and Innovation, Hyogo, Japan; 2Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan; 3Department of Radiology, Chibune General Hospital, Osaka, Japan Background: Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema.Methods: This study included 112 patients who had undergone computed tomography and pulmonary function test. Low-attenuation lung regions were evaluated by the homology method, and homology-based emphysema quantification (b0, b1, nb0, nb1, and R was performed. For comparison, the percentage of low-attenuation lung area (LAA% was also obtained. Relationships between emphysema quantification and pulmonary function test results were evaluated by Pearson’s correlation coefficients. In addition to the correlation, the patients were divided into the following three groups based on guidelines of the Global initiative for chronic Obstructive Lung Disease: Group A, nonsmokers; Group B, smokers without COPD, mild COPD, and moderate COPD; Group C, severe COPD and very severe COPD. The homology-based emphysema quantification and LAA% were compared among these groups.Results: For forced expiratory volume in 1 second/forced vital capacity, the correlation coefficients were as follows: LAA%, -0.603; b0, -0.460; b1, -0.500; nb0, -0.449; nb1, -0.524; and R, -0.574. For forced expiratory volume in 1 second, the coefficients were as follows: LAA%, -0.461; b0, -0.173; b1, -0.314; nb0, -0.191; nb1, -0.329; and R, -0.409. Between Groups A and B, difference in nb0 was significant (P-value = 0.00858, and those in the other types of quantification were not significant.Conclusion: Feasibility of the

  11. Assessment of effects of differences in trunk posture during Fowler’s position on hemodynamics and cardiovascular regulation in older and younger subjects

    Kubota S


    Full Text Available Satoshi Kubota,1 Yutaka Endo,1 Mitsue Kubota,1 Tomohiko Shigemasa2 1School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare, Odawara, Kanagawa, Japan; 2Department of Cardiology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan Background: Downward shifts in blood volume with changing position generally cause tachycardic responses. Age-related decreases in vagal nerve activity could contribute to orthostatic hypotension in older individuals. Fowler’s position is a reclined position with the back between 30° and 60°, used to facilitate breathing, eating, and other routine daily activities in frail and elderly patients. Objective: This study examined whether stroke volume (SV was higher and heart rate (HR lower in Fowler’s position with an upright upper trunk than in Fowler’s position with the whole trunk upright in both older and younger subjects, based on the assumption that lower HR would result from reduced sympathetic activation in older individuals. Methods: We assessed hemodynamics and HR variability from electrocardiography, noninvasive arterial pressure and impedance cardiography in 11 younger male subjects (age range, 20–22 years and 11 older male subjects (age range, 64–79 years, using three positions: supine, or Fowler’s positions with either 30° of lower trunk inclination and 60° of upper trunk inclination (UT60 or 60° of whole trunk inclination (WT60. Comparisons were then made between age groups and between positions. Results: Reductions in SV and tachycardic response were smaller with UT60 than with WT60, in both younger and older subjects. In addition, reduced tachycardic response with upright upper trunk appeared attributable to decreased vagal withdrawal in younger subjects and to reduced sympathetic activation in older subjects. Conclusion: Our findings indicate that an upright upper trunk during Fowler’s position allowed

  12. PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

    Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter


    . The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

  13. Geostatistical modelling of soil-transmitted helminth infection in Cambodia: do socioeconomic factors improve predictions?

    Karagiannis-Voules, Dimitrios-Alexios; Odermatt, Peter; Biedermann, Patricia; Khieu, Virak; Schär, Fabian; Muth, Sinuon; Utzinger, Jürg; Vounatsou, Penelope


    Soil-transmitted helminth infections are intimately connected with poverty. Yet, there is a paucity of using socioeconomic proxies in spatially explicit risk profiling. We compiled household-level socioeconomic data pertaining to sanitation, drinking-water, education and nutrition from readily available Demographic and Health Surveys, Multiple Indicator Cluster Surveys and World Health Surveys for Cambodia and aggregated the data at village level. We conducted a systematic review to identify parasitological surveys and made every effort possible to extract, georeference and upload the data in the open source Global Neglected Tropical Diseases database. Bayesian geostatistical models were employed to spatially align the village-aggregated socioeconomic predictors with the soil-transmitted helminth infection data. The risk of soil-transmitted helminth infection was predicted at a grid of 1×1km covering Cambodia. Additionally, two separate individual-level spatial analyses were carried out, for Takeo and Preah Vihear provinces, to assess and quantify the association between soil-transmitted helminth infection and socioeconomic indicators at an individual level. Overall, we obtained socioeconomic proxies from 1624 locations across the country. Surveys focussing on soil-transmitted helminth infections were extracted from 16 sources reporting data from 238 unique locations. We found that the risk of soil-transmitted helminth infection from 2000 onwards was considerably lower than in surveys conducted earlier. Population-adjusted prevalences for school-aged children from 2000 onwards were 28.7% for hookworm, 1.5% for Ascaris lumbricoides and 0.9% for Trichuris trichiura. Surprisingly, at the country-wide analyses, we did not find any significant association between soil-transmitted helminth infection and village-aggregated socioeconomic proxies. Based also on the individual-level analyses we conclude that socioeconomic proxies might not be good predictors at an

  14. Estimation of methane and nitrous oxide emissions from rice field with rice straw management in Cambodia.

    Vibol, S; Towprayoon, S


    To estimate the greenhouse gas emissions from paddy fields of Cambodia, the methodology of the Intergovernmental Panel on Climate Change (IPCC) guidelines, IPCC coefficients, and emission factors from the experiment in Thailand and another country were used. Total area under rice cultivation during the years 2005-2006 was 2,048,360 ha in the first crop season and 298,529 ha in the second crop season. The emission of methane from stubble incorporation with manure plus fertilizer application areas in the first crop season was estimated to be 192,783.74 ton higher than stubble with manure, stubble with fertilizer, and stubble without fertilizer areas. The fields with stubble burning emitted the highest emission of methane (75,771.29 ton) followed by stubble burning with manure (22,251.08 ton), stubble burning with fertilizer (13,213.27 ton), and stubble burning with fertilizer application areas (3,222.22 ton). The total emission of methane from rice field in Cambodia for the years 2005-2006 was approximately 342,649.26 ton (342.65 Gg) in the first crop season and 36,838.88 ton (36.84 Gg) in the second crop season. During the first crop season in the years 2005-2006, Battambang province emitted the highest amount of CH(4) (38,764.48 ton) and, in the second crop season during the years 2005-2006, the highest emission (8,262.34 ton) was found in Takeo province (8,262.34 ton). Nitrous oxide emission was between 2.70 and 1,047.92 ton in the first crop season and it ranged from 0 to 244.90 ton in the second crop season. Total nitrous oxide emission from paddy rice field was estimated to be 9,026.28 ton in the first crop season and 1,091.93 ton in the second crop season. Larger area under cultivation is responsible for higher emission of methane and nitrous oxide. Total emission of nitrous oxide by using IPCC default emission coefficient was approximately 2,328.85 ton. The total global warming potential of Cambodian paddy rice soil is 11,723,217.03 ton (11,723 Gg

  15. Impact and indication of early systemic corticosteroids for very severe community-acquired pneumonia

    Ugajin M


    Full Text Available Motoi Ugajin, Kenichi Yamaki, Natsuko Hirasawa, Takanori Kobayashi, Takeo YagiDepartment of Respiratory Medicine, Ichinomiya-Nishi Hospital, Ichinomiya City, Aichi Prefecture, JapanBackground: The efficacy of systemic corticosteroids in community-acquired pneumonia (CAP has not yet been confirmed. We prospectively investigated the clinical features of patients treated with early adjunctive systemic corticosteroids and its clinical impact in very severe CAP.Methods: One hundred and one consecutive CAP patients having a pneumonia severity index of >130 points were enrolled from August 2010 through February 2013. Early adjunctive systemic corticosteroids were defined as administration of systemic corticosteroids equivalent to prednisone of ≥20 mg/day added to initial antibiotics. The multivariate analysis was performed to evaluate the independent factors associated with mortality.Results: Thirty-two patients (31.7% died within 28 days of admission. Early adjunctive systemic corticosteroids were administered in 30 patients (29.7%, who more frequently had alteration of mental status, serious respiratory failure, or underlying lung diseases and received fluoroquinolones as initial antibiotics. In most patients treated with early adjunctive systemic corticosteroids, the dosage was less than 60 mg/day of an equivalent to prednisone by bolus intravenous infusion for a period shorter than 8 days. The occurrence of adverse events did not differ between the groups. Factors independently associated with mortality were blood urea nitrogen (hazard ratio [HR] 1.02, 95% confidence interval [CI] 1.00–1.04, serum albumin (HR 0.44, 95% CI 0.22–0.86, a requirement for intensive care (HR 4.93, 95% CI 1.75–13.87, and the therapy with early adjunctive systemic corticosteroids (HR 0.29, 95% CI 0.11–0.81.Conclusion: Early adjunctive systemic corticosteroids may have an effect to reduce the mortality in very severe CAP, although a larger-scale study is necessary

  16. Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study

    Saito H


    Full Text Available Hitoshi Saito,1,2 Koichiro Nomura,1,2,† Shinji Abe,1,2 Takashi Motegi,2,3 Takeo Ishii,2,3 Kumiko Hattori,2,3 Yuji Kusunoki,2,3 Akihiko Gemma,2 Kozui Kida2,3 1Department of Respiratory Medicine, Tokyo Metropolitan Hiroo Hospital, 2Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, 3Respiratory Care Clinic, Nippon Medical School †Koichiro Nomura passed away on July 30, 2014 Objective: Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD.Participants: Subjects included 87 patients either with COPD or at risk of COPD (symptomatic who underwent gastrectomy between December 2003 and October 2013 (group A, and 174 patients either with COPD or at risk of COPD, matched by age (±5 years, sex, and forced expiratory volume in 1 second (FEV1 as percentage of predicted (FEV1% predicted (±5% (group B.Methods: All patients underwent routine blood chemistry and pulmonary function tests, arterial blood gas analysis, 6-minute walk test (6MWT, high-resolution chest computed tomography scans, and nutritional assessments.Results: The mean duration postgastrectomy was 18.3±15.4 years. The mean FEV1 and FEV1% predicted were 2.07±0.76 L and 74.6±24.5%, respectively. Univariate analysis indicated that group A patients had significantly lower body mass index, fat-free mass index, and serum hemoglobin and albumin concentration (all P=0.00, and walked a significantly shorter distance in the 6MWT (P<0.05. Multivariate linear regression analysis for the distance in the 6MWT indicated that increased residual volume (RV to total lung capacity (TLC as percentage of predicted (%RV/TLC alone was an independent and significant predictor of reduced distances in the 6MWT.Conclusion: We concluded

  17. Frequency-dependent moment release of very low frequency earthquakes in the Cascadia subduction zone

    Takeo, A.; Houston, H.


    Episodic tremor and slip (ETS) has been observed in Cascadia subduction zone at two different time scales: tremor at a high-frequency range of 2-8 Hz and slow slip events at a geodetic time-scale of days-months. The intermediate time scale is needed to understand the source spectrum of slow earthquakes. Ghosh et al. (2014, IRIS abs) recently reported the presence of very low frequency earthquakes (VLFEs) in Cascadia. In southwest Japan, VLFEs are usually observed at a period range around 20-50 s, and coincide with tremors (e.g., Ito et al. 2007). In this study, we analyzed VLFEs in and around the Olympic Peninsula to confirm their presence and estimate their moment release. We first detected VLFE events by using broadband seismograms with a band-pass filter of 20-50 s. The preliminary result shows that there are at least 16 VLFE events with moment magnitudes of 3.2-3.7 during the M6.8 2010 ETS. The focal mechanisms are consistent with the thrust earthquakes at the subducting plate interface. To detect signals of VLFEs below noise level, we further stacked long-period waveforms at the peak timings of tremor amplitudes for tremors within a 10-15 km radius by using tremor catalogs in 2006-2010, and estimated the focal mechanisms for each tremor source region as done in southwest Japan (Takeo et al. 2010 GRL). As a result, VLFEs could be detected for almost the entire tremor source region at a period range of 20-50 s with average moment magnitudes in each 5-min tremor window of 2.4-2.8. Although the region is limited, we could also detect VLFEs at a period range of 50-100 s with average moment magnitudes of 3.0-3.2. The moment release at 50-100 s is 4-8 times larger than that at 20-50 s, roughly consistent with an omega-squared spectral model. Further study including tremor, slow slip events and characteristic activities, such as rapid tremor reversal and tremor streaks, will reveal the source spectrum of slow earthquakes in a broader time scale from 0.1 s to days.

  18. Effect of TNF antagonists on the productivity of daily work of patients with rheumatoid arthritis

    Furuya H


    Full Text Available Hidekazu Furuya,1 Tsuyoshi Kasama,1 Takeo Isozaki,1,2 Masayu Umemura,1 Kumiko Otsuka,1 Sakiko Isojima,1 Hiroyuki Tsukamoto,1 TakehiroTokunaga,1 Ryo Yanai,1 Ryo Takahashi11Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan; 2Department of Rheumatology,University of Michigan Medical School, Ann Arbor, MI, USAAbstract: Rheumatoid arthritis (RA is a significant cause of work disability and job loss. The resulting economic burden experienced by patients has received considerable research attention. This research assesses the effect of tumor necrosis factor (TNF antagonists (infliximab, etanercept on the ability of RA patients living in Japan to work and participate in society. A total of 42 patients with active RA were enrolled and given biological therapy for 12 months (mo. Of these patients, 14 were employed full-time, 6 were employed part-time, and 22 were not employed. Twenty-six patients were given infliximab, and sixteen were given etanercept. The amount of domestic labor performed before the biologics served as a baseline and was assigned a value of 0%. After treatment with biologics, the productivity was evaluated using the visual analog scale (VAS; −100 to +100 mm. The administration of TNF antagonists to RA patients who exhibited an insufficient response to medical treatment significantly improved the Disease Activity Score 28 (DAS 28 after both 6 mo and 12 mo (P < 0.0001. A significant correlation was found between the improvement in their DAS 28 and improvements in their work situation (Productivity VAS (P < 0.05. Of particular interest is the significant correlation between the values of baseline mHAQ and the percent changes of Productivity VAS that was observed after 6 mo and 12 mo (P < 0.05. Our findings indicate that medical treatment of RA with TNF antagonists improves the patients' ability to perform their jobs and housekeeping. Because loss of productivity is an important

  19. Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease

    Hattori K


    Full Text Available Kumiko Hattori, Takeo Ishii, Takashi Motegi, Yuji Kusunoki, Akihiko Gemma, Kozui Kida Department of Pulmonary Medicine and Oncology; Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan Background: High-sensitivity cardiac troponin T (hs-cTnT in serum is a useful marker of acute myocardial injury, yet information is limited in patients with chronic obstructive pulmonary disease. We aimed to explore the association between hs-cTnT levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease and at-risk individuals. Methods: We examined community-dwelling adults with/without chronic obstructive pulmonary disease, with a life-long smoking history, current symptoms of dyspnea during exertion, prolonged coughing, and/or sputum. Serum hs-cTnT concentrations were measured, and subjects underwent pulmonary function tests, high-resolution computed tomography of the chest, an echocardiogram, and a 6-minute walking test. Results: Eighty-six stable patients were identified (mean age 65.5 years; predicted forced expiratory volume in 1 second [FEV1% predicted] 75.0%. Their overall mean hs-cTnT level was 0.008 ng/mL. Logarithmically transformed hs-cTnT levels significantly and positively correlated with age, smoking index, serum high-sensitivity C-reactive protein levels, right ventricle systolic pressure, low attenuation area percentage, and brain natriuretic peptide levels (range r=0.231–0.534, P=0.000 to P=0.042. Further, logarithmically transformed hs-cTnT values significantly and negatively correlated with forced vital capacity, FEV1% predicted, diffusion capacity, arterial oxygen tension, and 6-minute walking distance (range r= -0.482 to -0.377, P=0.000 to P=0.002. Multivariate analyses showed that hs-cTnT values varied independently according to the following three parameters: high-sensitivity C-reactive protein levels (B=0.157, ß=0.450, t=3.571, P=0.001, age (B=0.008, ß=0.352, t=2.789, P=0

  20. Bone integration capability of nanopolymorphic crystalline hydroxyapatite coated on titanium implants

    Suzuki T


    Full Text Available Masahiro Yamada*, Takeshi Ueno*, Naoki Tsukimura, Takayuki Ikeda, Kaori Nakagawa, Norio Hori, Takeo Suzuki, Takahiro OgawaLaboratory of Bone and Implant Sciences, The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA *These authors contributed equally to this workAbstract: The mechanism by which hydroxyapatite (HA-coated titanium promotes bone–implant integration is largely unknown. Furthermore, refining the fabrication of nanostructured HA to the level applicable to the mass production process for titanium implants is challenging. This study reports successful creation of nanopolymorphic crystalline HA on microroughened titanium surfaces using a combination of flame spray and low-temperature calcination and tests its biological capability to enhance bone–implant integration. Sandblasted microroughened titanium implants and sandblasted + HA-coated titanium implants were subjected to biomechanical and histomorphometric analyses in a rat model. The HA was 55% crystallized and consisted of nanoscale needle-like architectures developed in various diameters, lengths, and orientations, which resulted in a 70% increase in surface area compared to noncoated microroughened surfaces. The HA was free from impurity contaminants, with a calcium/phosphorus ratio of 1.66 being equivalent to that of stoichiometric HA. As compared to microroughened implants, HA-coated implants increased the strength of bone–implant integration consistently at both early and late stages of healing. HA-coated implants showed an increased percentage of bone–implant contact and bone volume within 50 µm proximity of the implant surface, as well as a remarkably reduced percentage of soft tissue intervention between bone and the implant surface. In contrast, bone volume outside the 50 µm border was lower around HA-coated implants. Thus, this study

  1. Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

    Ishizaki K


    Full Text Available Ken Ishizaki*, Yoshihiko Sugita*, Fuminori Iwasa, Hajime Minamikawa, Takeshi Ueno, Masahiro Yamada, Takeo Suzuki, Takahiro OgawaLaboratory for Bone and Implant Sciences, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA*Authors contributed equally to this workBackground: The independent role of the surface chemistry of titanium in determining its biological properties is yet to be determined. Although titanium implants are often in contact with muscle tissue, the interaction of muscle cells with titanium is largely unknown. This study tested the hypotheses that the surface chemistry of clinically established microroughened titanium surfaces could be controllably varied by coating with a minimally thin layer of TiO2 (ideally pico-to-nanometer in thickness without altering the existing topographical and roughness features, and that the change in superficial chemistry of titanium is effective in improving the biological properties of titanium.Methods and results: Acid-etched microroughened titanium surfaces were coated with TiO2 using slow-rate sputter deposition of molten TiO2 nanoparticles. A TiO2 coating of 300 pm to 6.3 nm increased the surface oxygen on the titanium substrates in a controllable manner, but did not alter the existing microscale architecture and roughness of the substrates. Cells derived from rat skeletal muscles showed increased attachment, spread, adhesion strength, proliferation, gene expression, and collagen production at the initial and early stage of culture on 6.3 nm thick TiO2-coated microroughened titanium surfaces compared with uncoated titanium surfaces.Conclusion: Using an exemplary slow-rate sputter deposition technique of molten TiO2 nanoparticles, this study demonstrated that titanium substrates, even with microscale roughness, can be sufficiently chemically modified to

  2. A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

    Yoshida Y


    Full Text Available Yoichiro Yoshida,1 Keiji Hirata,2 Hiroshi Matsuoka,3 Shigeyoshi Iwamoto,4 Masahito Kotaka,5 Hideto Fujita,6 Naoya Aisu,1 Seiichiro Hoshino,1 Takeo Kosaka,6 Kotaro Maeda,3 Fumiaki Kiyomi,7 Yuichi Yamashita1 1Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan; 2Department of Surgery, Fukuoka Sanno Hospital, Fukuoka, Japan; 3Department of Surgery, Fujita Health University School of Medicine, Toyoake, Japan; 4Department of Surgery, Kansai Medical University Hirakata Hospital, Osaka, Japan; 5Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan; 6Department of Surgical Oncology, Kanazawa Medical University, Uchinada, Japan; 7Academia, Industry and Government Collaborative Research Institute of Translational Medicine for Life Innovation, Fukuoka University, Fukuoka, Japan Background: Patients with colorectal cancer treated with oxaliplatin are at risk of hypersensitivity reactions, with the incidence estimated to be 12%–20%. Coinfusion of dexamethasone and oxaliplatin could potentially reduce the incidence of these reactions, but oxaliplatin is reported to be incompatible with alkaline compounds in solution. However, in a previous retrospective study we found that the pH of a solution of dexamethasone and oxaliplatin was less than 7.4, and that hypersensitivity to oxaliplatin could have been prevented by coinfusion of dexamethasone. We aimed to evaluate the effectiveness of coinfusion of dexamethasone and oxaliplatin to prevent oxaliplatin-induced hypersensitivity reactions.Patients and methods: The AVOID trial was a prospective, multicenter, open-label, single-arm Phase II trial conducted from January to September 2013. The study included 73 patients who received capecitabine plus oxaliplatin (XELOX or XELOX plus bevacizumab therapy for colorectal cancer. In all patients, oxaliplatin was administered in combination with dexamethasone. The primary outcome measure was the presence of

  3. Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals.

    Takanari, Jun; Nakahigashi, Jun; Sato, Atsuya; Waki, Hideaki; Miyazaki, Shogo; Uebaba, Kazuo; Hisajima, Tatsuya


    The aim of this study was to examine the effectiveness of Enzyme-Treated Asparagus Extract (ETAS) on improving stress response. A randomized, double-blind, placebo-controlled cross-over trial was undertaken in healthy volunteers. ETAS (150 mg/d) or a placebo was consumed for 28 d, with a washout period. Psychological parameters were examined using a self-report scale questionnaire and psychological stress was applied using the Uchida-Kraepelin (U-K) test. During the stress load, autonomic nervous function was analyzed. After the stress load, a profile of mood states (POMS) psychological rating was performed, and serum cortisol, plasma catecholamine, salivary secretory immunoglobulin A (sIgA), and salivary cortisol were analyzed. ETAS intake improved the self-reported rating for the items "Feel tired," "Hard to get up," and "Feel heavy" in the psychological questionnaire; ameliorated the self-reported rating for the items "Depression-Dejection" and "Fatigue" in the POMS questionnaire; and increased salivary sIgA levels after the U-K test. In contrast, serum and salivary cortisol levels, and plasma catecholamine did not change. During the U-K test, ETAS significantly upregulated the sympathetic nerve activity. Furthermore, ETAS intake significantly increased the number of answers and the number of correct answers in the U-K test, suggesting that it might improve office work performance with swiftness and accuracy under stressful conditions. In conclusion, ETAS supplementation reduced feelings of dysphoria and fatigue, ameliorated quality of sleep, and enhanced stress-load performance as well as promoted stress response by increasing salivary sIgA levels. These data suggest ETAS intake may exert beneficial effects, resulting from well-controlled stress management, in healthy individuals.

  4. Effect of dried-bonito broth on mental fatigue and mental task performance in subjects with a high fatigue score.

    Kuroda, Motonaka; Ishizaki, Taichi; Maruyama, Tomoaki; Takatsuka, Yoji; Kuboki, Tomifusa


    Dried-bonito broth is commonly employed as a soup and sauce base in Japanese cuisine and is considered to be a nutritional supplement that promotes recovery from fatigue. Previous human trials suggest that the ingestion of dried-bonito broth improves several mood states; however, its effect on fatigue has not yet been clarified. The aim of this study was to clarify the effects of daily ingestion of dried-bonito broth on fatigue and cognitive parameters by a placebo-controlled double blind crossover trial. Forty-eight subjects with fatigue symptoms ingested the dried-bonito broth or a placebo solution every day for 4 weeks. Mood states were evaluated by the Profile of Mood States (POMS), and mental task performance was evaluated by the Uchida-Kraepelin psychodiagnostic (UKP) test. Fatigue and total mood disturbance (TMD) scores on the POMS test decreased significantly during the dried-bonito broth ingestion (p<0.05), but did not change significantly during placebo ingestion. The change in vigor score during dried-bonito broth ingestion was significantly higher than that during placebo ingestion at 2 weeks (p<0.05). The results of the UKP test indicate that the numbers of both total answers and correct answers significantly increased during dried-bonito broth ingestion (p<0.05), while no significant changes were observed in the placebo ingestion. These results suggest that the daily ingestion of dried-bonito broth may improve the mood states, may reduce mental fatigue and may increase performance on a simple calculation task.

  5. Near Infrared Spectra of Large Polycyclic Aromatic Hydrocarbons.

    Mattioda, A. L.; Hudgins, D. M.; Bauschlicher, C. W.; Allamandola, L. J.

    The widespread, mid-IR interstellar emission features at 3.3, 6.2, 7.7, 8.6, and 11.2 microns are generally attributed to vibrationally excited polycyclic aromatic hydrocarbons (PAHs). Since these features typcially originate from radiation-rich regions, it has been generally thought that UV photons must dominate the interstellar excitation process since PAHs have very strong UV absorption bands. However, observations have shown that lower energy photons can also pump the emission (Aitken and Roche, Uchida and Sellgren), raising questions about the PAH model. Although it has long been known that larger PAHs should absorb at longer wavelengths (e.g. Schutte et. al., Salama et al., Li and Draine) data was not available for the isolated, neutral and ionized PAHs of sizes comparable to those thought responsible for the interstellar emission features. Here the matrix-isolated near-IR (NIR) spectra (from 0.7 to 2.5 microns) are presented for the anions and cations of PAHs ranging in size from C34H16 to C50H22. These molecules are characterized by strong absorption bands in this region, bands that can account for the emission of the interstellar features from UV poor regions. These NIR PAH transitions could also contribute to the extinction curve associated with the diffuse interstellar medium. For example, band overlap, as expected from a mixture of PAHs, can contribute to the continuum. Overlapping broad bands could lead to slight undulations in the continuum reminiscent of the Very Broad Structure (VBS, e.g. Hayes et al.). Furthermore, as previously pointed out, individual PAH bands may contribute to the diffuse interstellar band (DIB) spectrum (e.g. Romanini)

  6. Experiments and analytical studies related to blowdown and containment thermal hydraulics on CSF

    Dutta, Anu, E-mail:; Thangamani, I.; Shanware, V.M.; Rao, K.S.; Gera, B.; Ravi Kiran, A.; Goyal, P.; Verma, Vishnu; Sharma, P.K.; Agrawal, M.K.; Ganju, S.; Singh, R.K.


    Highlights: • Blowdown and containment thermal hydraulics experiments conducted in CSF. • RELAP5, ASTEC and CONTRAN codes used for analysis. • Containment peak pressure and temp predicted close to experimental values. • CONTRAN and ASTEC codes predict early containment depressurization. • Numerical procedure, benchmarked for loss of coolant accident in nuclear reactors. - Abstract: Containment Studies Facility (CSF) is volumetrically scaled down model of Indian Pressurized Heavy Water Reactor (IPHWR) containment for simulating LOCA/MSLB conditions which consists of concrete containment model (CM) and Primary Heat Transport Model (PHTM) vessel. Blowdown experiments at different initial vessel pressure conditions were recently conducted at CSF and the vessel and containment parameters such as pressure, temperature and level transients have been recorded during the experiments. The experimental results have been used for benchmarking of numerical procedure adopted for evaluating LOCA/MSLB conditions in nuclear containment. The numerical procedure involves simulation of blowdown phenomena using RELAP5 code for evaluating mass and energy discharge rates, which are then used for calculating containment pressure–temperature transients using ASTEC and in-house CONTRAN codes. Predictions of major parameters of vessel and containment model were found to be in good agreement with that of experimental data. In containment thermal hydraulic calculations, condensation heat transfer coefficient affects the containment pressure–temperature transients. Various empirical condensation models like Tagami, Uchida and Diffusion models have been incorporated in CONTRAN code and suitable condensation model has been identified for which predicted pressure values are close to the experimental one. The details of the experimental and analytical studies conducted are presented in this paper.

  7. Energetic Mechanism of Cytochrome c-Cytochrome c Oxidase Electron Transfer Complex Formation under Turnover Conditions Revealed by Mutational Effects and Docking Simulation.

    Sato, Wataru; Hitaoka, Seiji; Inoue, Kaoru; Imai, Mizue; Saio, Tomohide; Uchida, Takeshi; Shinzawa-Itoh, Kyoko; Yoshikawa, Shinya; Yoshizawa, Kazunari; Ishimori, Koichiro


    Based on the mutational effects on the steady-state kinetics of the electron transfer reaction and our NMR analysis of the interaction site (Sakamoto, K., Kamiya, M., Imai, M., Shinzawa-Itoh, K., Uchida, T., Kawano, K., Yoshikawa, S., and Ishimori, K. (2011) Proc. Natl. Acad. Sci. U.S.A. 108, 12271-12276), we determined the structure of the electron transfer complex between cytochrome c (Cyt c) and cytochrome c oxidase (CcO) under turnover conditions and energetically characterized the interactions essential for complex formation. The complex structures predicted by the protein docking simulation were computationally selected and validated by the experimental kinetic data for mutant Cyt c in the electron transfer reaction to CcO. The interaction analysis using the selected Cyt c-CcO complex structure revealed the electrostatic and hydrophobic contributions of each amino acid residue to the free energy required for complex formation. Several charged residues showed large unfavorable (desolvation) electrostatic interactions that were almost cancelled out by large favorable (Columbic) electrostatic interactions but resulted in the destabilization of the complex. The residual destabilizing free energy is compensated by the van der Waals interactions mediated by hydrophobic amino acid residues to give the stabilized complex. Thus, hydrophobic interactions are the primary factors that promote complex formation between Cyt c and CcO under turnover conditions, whereas the change in the electrostatic destabilization free energy provides the variance of the binding free energy in the mutants. The distribution of favorable and unfavorable electrostatic interactions in the interaction site determines the orientation of the binding of Cyt c on CcO.

  8. Portacaval shunt established in six dogs using magnetic compression technique.

    Xiaopeng Yan

    Full Text Available BACKGROUND AND AIMS: Installing the transjugular intrahepatic portosystemic shunt for portal hypertension is relatively safe, but complications are still high. To explore a new method of portacaval shunt, the magnetic compression technique was introduced into the shunting procedure. METHODS: A portal-inferior vena cava shunt was performed on 6 male mongrel dogs by two hemocompatible Nd-Fe-B permanent magnets, parent and daughter. The parent magnet was applied to the inferior vena cava guided by a catheter through the femoral vein. The daughter magnet was moved to the anastomosis position on the portal vein with a balloon catheter through the splenic vein. After the daughter magnet reached the target position, the two magnets acted to compress the vessel wall and hold it in place. Five to 7 days later, under X-ray guidance, the magnets were detached from the vessel wall with a rosch-uchida transjugular liver access set. One month later, histological analysis and portal venography were performed. RESULTS: 5-7 days after the first surgery, a mild intimal hyperplasia in the portal vein and the inferior vena cava, and continuity of the vascular adventitia from the portal vein to the inferior vena cava as observed. During the second surgery, the contrast media could be observed flowing from the portal vein into the inferior vena cava. Portal venography revealed that the portosystemic shunt was still present one month after the second surgery. CONCLUSIONS: Magnamosis via a device of novel design was successfully used to establish a portacaval shunt in dogs.

  9. Elasticity of orthoenstatite at high-pressure

    Zhang, D.; Jackson, J. M.; Chen, B.; Zhao, J.; Yan, J.


    Orthoenstatite is an abundant yet complex mineral in Earth's upper mantle. Despite its abundance, the properties of orthopyroxene at high pressure remain ambiguous (e.g., Zhang et al. 2011; Jahn 2008; Kung et al. 2004). We explored select properties of a synthetic powdered orthoenstatite (Mg0.8757Fe0.13)2Si2O6 sample by X-ray diffraction (XRD) and nuclear resonance inelastic X-ray scattering (NRIXS) as a function of pressure in a neon pressure medium at 300 K. The XRD measurements were carried out at beamline 12.2.2 of the Advanced Light Source (Berkeley, CA), and the sample was studied up to 34 GPa. NRIXS measurements were carried out at sector 3ID-B of the Advanced Photon Source (Chicago, IL) in the pressure range of 3 to 17 GPa. From the raw NRIXS data, the partial phonon density of states (DOS) was derived (e.g., Sturhahn 2004). The volume (or pressure) dependence of several properties, such as the Lamb-Mössbauer factor, mean force constant, specific heat, vibrational entropy, and vibrational kinetic energy were determined from the DOS. We will discuss our results from these combined studies and the implications for Earth's upper mantle. References Zhang, D., J.M. Jackson, W. Sturhahn, and Y. Xiao (2011): Local structure variations observed in orthoenstatite at high-pressures. American Mineralogist, in press. Jahn, S. (2008) High-pressure phase transitions in MgSiO3 orthoenstatite studied by atomistic computer simulation. American Mineralogist, 93(4), 528-532. Kung, J., Li, B., Uchida, T., Wang, Y., Neuville, D., and Liebermann, R. (2004) In situ measurements of sound velocities and densities across the orthopyroxene high-pressure clinopyroxene transition in MgSiO3 at high pressure. Physics of the Earth and Planetary Interiors, 147(1), 27-44. Sturhahn, W. (2004): Nuclear Resonant Spectroscopy. J. Phys. Condens. Matter, 16, S497-S530.

  10. Study design and patient recruitment for the Japan Polyp Study

    Sano Y


    Full Text Available Yasushi Sano,1,2 Takahiro Fujii,3,4 Takahisa Matsuda,3 Yasushi Oda,5,6 Shin'ei Kudo,7 Masahiro Igarashi,8 Hiroyasu Iishi,9 Kazuhiro Kaneko,1,10 Kinichi Hotta,3,11,12 Nozomu Kobayashi,3,13 Yuichiro Yamaguchi,12 Kiyonori Kobayashi,8 Hideki Ishikawa,14 Yoshitaka Murakami,15 Tadakazu Shimoda,16 Takahiro Fujimori,17 Yoichi Ajioka,18 Hirokazu Taniguchi,16 Hiroaki Ikematsu,1,3 Kazuo Konishi,10 Yutaka Saito,3 Shigeaki Yoshida1,19 1Department of Gastroenterology, Endoscopy Division, National Cancer Center Hospital East, Kashiwa, 2Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care (iMEC, Sano Hospital, Kobe, 3Endoscopy Division, National Cancer Center Hospital, Tokyo, 4Takahiro Fujii Clinic, Tokyo, 5Hattori GI Endoscopy and Gastroenterology Clinic, Kumamoto, 6Oda GI Endoscopy and Gastroenterology Clinic, Kumamoto, 7Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, 8Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, 9Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, 10Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo, 11Department of Gastroenterology, Saku Central Hospital, Saku, 12Division of Endoscopy, Shizuoka Cancer Center, Mishima, 13Department of Diagnostic Imaging, Tochigi Cancer Center, Utsunomiya, 14Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 15Department of Medical Statistics, Shiga University of Medical Science, Otsu, 16Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, 17Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Mibu, 18Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 19Aomori Prefectural Hospital, Aomori

  11. High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population

    Takata Y


    Full Text Available Yutaka Takata,1 Toshihiro Ansai,2 Inho Soh,2 Shuji Awano,2 Ikuo Nakamichi,1 Sumio Akifusa,3 Kenichi Goto,1 Akihiro Yoshida,2 Hiroki Fujii,1 Ritsuko Fujisawa,1 Kazuo Sonoki31Division of General Internal Medicine, 2Division of Community Oral Health Science, 3Department of Oral Health and Environment, School of Oral Health Science, Kyushu Dental University, Kitakyushu, JapanBackground: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population.Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan’s Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity.Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899–0.978, P = 0.003 with each one-point increase in participants’ scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one

  12. 2014 Nuclear Fusion Prize Acceptance Speech 2014 Nuclear Fusion Prize Acceptance Speech

    Snyder, P. B.


    and numerical techniques which enable efficient quantitative study of peeling-ballooning modes. More broadly, I would like to thank the full DIII-D, C-Mod and JET teams, the LLNL and General Atomics Theory groups, and the York Plasma Institute. In addition, I would like to thank the US DOE Office of Fusion Energy Sciences, EURATOM, and the UK EPSRC for supporting this research. On a more personal note, I would like to thank my mentors over the years, including Nat Fisch, Greg Hammett, Ron Waltz, Vincent Chan, and Tony Taylor, and numerous colleagues who provided insight related to this work, including Lang Lao, Alan Turnbull, Ming Chu, Bob Miller, Rip Perkins, John Greene, Keith Burrell, John Ferron, Mickey Wade, Wayne Solomon, George McKee, Zheng Yan, Andrea Garofalo, Raffi Nazikian, Jack Connor, Jim Hastie, Chris Hegna, Samuli Saarelma, Guido Huijsmans, Alberto Loarte, Yutaka Kamada, Naoyuki Oyama, Hajime Urano, Nobuyuki Aiba, Andrew Kirk, David Dickinson, Lorne Horton, Costanza Maggi, Wolfgang Suttrop, P.A. Schneider, Rajesh Maingi, Amanda Hubbard, Ahmed Diallo, John Walk, and Matthew Leyland. Recently, the model developed in this paper has been used to discover a new regime of operation, the Super H-Mode, and to shed light on mechanisms for suppressing Edge Localized Modes. I hope that the model will continue to be useful, both as a tool for predicting and optimizing pedestal and fusion performance, and as a platform on which the fusion community continues to build our understanding of the complex physics of the edge barrier region, which plays such an important role in overall confinement and stability.

  13. A numerical study on a lumped-parameter model and a CFD code coupling for the analysis of the loss of coolant accident in a reactor containment; Etude numerique 0D-multiD pour l'analyse de perte de refrigerant dans une enceinte de confinement d'un reacteur nucleaire

    Choi, Y.J.


    In the case of PWR severe accident (Loss of Coolant Accident, LOCA), the inner containment ambient properties such as temperature, pressure and gas species concentrations due to the released steam condensation are the main factors that determine the risk. For this reason, their distributions should be known accurately, but the complexity of the geometry and the computational costs are strong limitations to conduct full three-dimensional numerical simulations. An alternative approach is presented in this thesis, namely, the coupling between a lumped-parameter model and a CFD. The coupling is based on the introduction of a 'heat transfer function' between both models and it is expected that large decreases in the CPU-costs may be achieved. First of all, wall condensation models, such as the Uchida or the Chilton-Colburn models which are implemented in the code CAST3M/TONUS, are investigated. They are examined through steady-state calculations by using the code TONUS-0D, based on lumped parameter models. The temperature and the pressure within the inner containment are compared with those reported in the archival literature. In order to build the 'heat transfer function', natural convection heat transfer is then studied by using the code CAST3M for a partitioned cavity which represents a simplified geometry of the reactor containment. At a first step, two-dimensional natural convection heat transfer without condensation is investigated only. Either the incompressible-Boussinesq fluid flow model or the asymptotic low Mach model are considered for solving the time dependent conservation equations. The SUPG finite element method and the implicit scheme are applied for the numerical discretization. The computed results are qualified by the second-order Richardson extrapolation method which allows obtaining the so-called 'Exact values', i.e. grid size independent values. The computations are also validated through non-partitioned cavity case

  14. The Estimation and Inversion of Magnetotelluric Data with Static Shift

    Wang, X.; Zhou, J.; Zhang, J.; Min, G.; Xia, S.


    (12): 2102-2106.[2] Ogawa Y, Uchida T. A two-dimensional magnetotelluric inversion assuming Gaussian static shift[J]. Geophysical Journal International, 1996, 126(1): 69-76.

  15. Selenium extraction: development on extraction chromatographic resins compatible with Diffusive Gradient in Thin film (DGT)

    Rad, S.; Dirks-Fandrei, C.; Happel, S. A.; Bombard, A.; Cary, L.


    Measurement of Selenium is of importance regarding public health as the ratio between beneficial daily intake and toxicity is rather low [1], [2]. Also from the radiological perspective, Se-79 as a long-lived fission nuclide (T1/2=2.8x105y) with high mobility in environment, is of concern regarding waste management and decommissioning [3], [4]. Due to the existence of different oxidation states Selenium has a complex speciation chemistry which makes extraction and separation schemes not straightforward. The aim of this research is to develop extraction methods for Selenium based on extraction chromatographic resins allowing for the extraction of Se(VI), as well as Se(IV), from water samples for later use on DGT (Diffusive Gradients in Thin films) devices. Extraction chromatographic resins have been tested and characterized for Se and other elements. For Se(VI) a commercially available Aliquat 336 based extraction chromatographic resin (TEVA resin[5]) was found to be most suitable, for Se(IV) a newly developed extraction chromatographic resin based on Piazselenol chemistry was found to be most effective, data on the selectivity of this resin will be presented. The extraction of Se(IV) and Se(VI) by these resins was tested on water sampled in Lille City, where a high Se spatial variability has been observed. Concentrations in groundwater can reach 30µg/L as a consequence; most Se-contaminated wells are no longer exploited by the water operators. One of the applications of this development is to be able to measure Se concentrations insitu in contaminated areas including very complex object such as hyporheic zone. [1] Cary L. et al. Applied Geochemistry 48 (2014) 70-82 [2] Chen C. et al. Biological Trace Element Research Vols. 71-72 (1999) 131-138 [3] last access 03/03/2016 [4] Uchida et al. WM2009 Conference, March 1-5, 2009, Phoenix, AZ [5

  16. Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus: a randomized controlled trial

    Wada K


    Full Text Available Kentaro Wada,1 Yuko Wada,2 Haruhito Adam Uchida,3 Shuichi Tsuruoka4 1Division of Nephrology and Dialysis, Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, Hiroshima, 2Department of Internal Medicine, Central Hospital, Hiroshima, 3Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 4Division of Nephrology, Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC and calcium carbonate (CC on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV, intima-media thickness (IMT, bone mineral density (BMD, and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC and bone alkaline phosphatase (BAP were examined in 43 type 2 diabetes HD patients treated with LC (n=21 or CC (n=22 for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC. The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P<0.05, after 24-month treatment; it remained unchanged in the LC group (median: 1,830.5 to 2,018.3 cm/s. However, the difference between the groups did not reach statistical significance. Changes in IMT and BMD were not different between the two groups. Changes in serum phosphorus, corrected calcium, and intact parathyroid hormone levels were similar between the groups. The incidence of fracture was 0% (0/19 in the LC group, and 13.6% (3/22 in the CC group (P=0.2478. The OC/BAP ratio increased significantly in the LC group (median: 0.83 to 2.47, compared with in the CC group (median: 0.77 to 1.40 (P=0.036. Conclusion: From

  17. Spatiotemporal characteristics and mechanisms of intracellular Ca(2+) increases at fertilization in eggs of jellyfish (Phylum Cnidaria, Class Hydrozoa).

    Deguchi, Ryusaku; Kondoh, Eri; Itoh, Junko


    We have clarified, for the first time, the spatiotemporal patterns of intracellular Ca(2+) increases at fertilization and the Ca(2+)-mobilizing mechanisms in eggs of hydrozoan jellyfish, which belong to the evolutionarily old diploblastic phylum, Cnidaria. An initial Ca(2+) increase just after fertilization took the form of a Ca(2+) wave starting from one cortical region of the egg and propagating to its antipode in all of four hydrozoan species tested: Cytaeis uchidae, Cladonema pacificum, Clytia sp., and Gonionema vertens. The initiation site of the Ca(2+) wave was restricted to the animal pole, which is known to be the only area of sperm-egg fusion in hydrozoan eggs, and the wave propagating velocity was estimated to be 4.2-5.9 mum/s. After a Ca(2+) peak had been attained by the initial Ca(2+) wave, the elevated Ca(2+) gradually declined and returned nearly to the resting value at 7-10 min following fertilization. Injection of inositol 1,4,5-trisphosphate (IP(3)), an agonist of IP(3) receptors (IP(3)R), was highly effective in inducing a Ca(2+) increase in unfertilized eggs; IP(3) at a final intracellular concentration of 12-60 nM produced a fully propagating Ca(2+) wave equivalent to that observed at fertilization. In contrast, a higher concentration of cyclic ADP-ribose (cADPR), an agonist of ryanodine receptors (RyR), only generated a localized Ca(2+) increase that did not propagate in the egg. In addition, caffeine, another stimulator of RyR, was completely without effect. Sperm-induced Ca(2+) increases in Gonionema eggs were severely affected by preinjection of heparin, an inhibitor of Ca(2+) release from IP(3)R. These results strongly suggest that there is a well-developed IP(3)R-, but not RyR-mediated Ca(2+) release mechanism in hydrozoan eggs and that the former system primarily functions at fertilization. Our present data also demonstrate that the spatial characteristics and mechanisms of Ca(2+) increases at fertilization in hydrozoan eggs resemble

  18. Hydrogen solubility in LaNi{sub 5}

    Seta, S. [Tokai Univ., Hiratsuka, Kanagawa (Japan). Dept. of Appl. Phys.; Uchida, H. [Tokai Univ., Hiratsuka, Kanagawa (Japan). Dept. of Appl. Phys.


    In a previous study (H. Uchida, A. Hisano, K. Terao, N. Sato and A. Nagashima, J. Less-Common Met., 172-174 (1991) 1018), we pointed out that LaNi{sub 5} powder samples exhibit higher H solubilities than block samples at H concentrations lower than [H]/[LaNi{sub 5}]=1 x 10{sup -1}. This may be ascribed to the ready stress relaxation of small alloy particles and to the limited expansibility of block samples with larger crystal grains. In this investigation, the pressure-composition-temperature (P-C-T) relations were measured for the LaNi{sub 5}-H system using well annealed stoichiometric LaNi{sub 5.0}. The size of the alloy samples was extensively changed from fine powders with a 20 {mu}m median size to a cubic block sample with 10.5 mm in the side length to examine the dependence of H solubility on the sample volume and stress accumulation. The systematic measurements revealed that the dependence of H solubility on sample size vanishes when the particle size becomes lower than 50-64 {mu}m in diameter or when the cubic block sample size exceeds 9 mm in the side length. The relative partial molar enthalpy {Delta}/4H{sub H} for H solution was found to be dependent on sample size. At H concentrations lower than [H]/[LaNi{sub 5}]=3.5 x 10{sup -2}, the {Delta}/4H{sub H} values for all samples were almost constant independent of H concentration; however, the {Delta}/4H{sub H} became more positive as the sample size was reduced, indicating reduction of attractive metal-H interactions because of ready volume expansions of fine particles. With increasing H concentration at [H]/[LaNi{sub 5}]>3.5 x 10{sup -2}, the {Delta}/4H{sub H} values tended to become more positive and this effect became more marked as the sample size was increased from fine particles to blocks with larger grains, which may be caused by the accumulation of higher compressive stresses in block samples. (orig.)

  19. Characteristics of frictional properties' relationship with afterslip propagation speed

    Ariyoshi, Keisuke; Matsuzawa, Toru; Burgmann, Roland; Hasegawa, Akira; Hino, Ryota; Hori, Takane


    The propagation speed of postseismic slip seems to vary from place to place. For the 2003 Tokachi-Oki earthquake (M8), there was a time lag of about 80 minutes for the largest aftershock (M7.4) at about 40 km distance off Tokachi [Miyazaki and Larson, 2008 GRL] and of one year for the M7 earthquakes off Kushiro about 160 km away [Murakami et al., 2006 GRL]. If these aftershocks were triggered by ΔCFS increase in the passage of afterslip [Uchida et al., 2009 Gondwana Res], these time lags suggest that the propagation speed of the afterslip from the mainshock to the largest aftershock is significantly higher than to the M7 aftershocks off Kushiro. On the Sanriku-Haruka-Oki earthquakes, Matsuzawa et al. [2004 EPS] pointed out that propagation speed of the postseismic slip seems to be on the order of 10 km/day for the shallower part of the subduction plate boundary while it appears to be 10 km/month for the deeper part. These results indicate that the propagation speed of postseismic slip depends on frictional properties and effective normal stress in addition to slip velocity. To better understand the frictional properties controlling the propagation speed of postseismic slip, some numerical simulations of interplate earthquakes based on a rate- and state-dependent friction law (RSF) [Dieterich, 1979 JGR; Ruina, 1983 JGR] have been recently performed. These previous studies suggest the propagation speed of postseismic slip becomes lower in case of higher frictional stability, longer characteristic slip distance [Kato and Hirasawa, 1999 PAGEOPH], and higher effective normal stress [Ariyoshi et al., 2007 EPSL]. Since we do not quantitatively understand why such cases make the postseismic slip propagation slower, it is necessary to find an analytical relation between the frictional properties and the propagation speed of postseismic slip. In this study, we develop an expression for the propagation speed of postseismic slip as a function of frictional properties

  20. The Showa Sanriku earthquake of 1933 March 2: a global seismological reassessment

    Okal, Emile A.; Kirby, Stephen H.; Kalligeris, Nikos


    After 83 yr, the great normal-faulting earthquake of 1933 March 2, which took place off the Japan Trench and produced a devastating tsunami on the Sanriku coast and damaging waves in Hawaii, remains the largest recorded normal-faulting earthquake. This study uses advanced methods to investigate this event using far-field seismological and tsunami data and complements a sister study by Uchida et al. which used exclusively arrival times at Japanese stations. Our relocation of the main shock (39.22°N, 144.45°E, with a poorly constrained depth of less than 40 km) places it in the outer trench slope, below a seafloor depth of ˜6500 m, in a region of horst-and-graben structure, with fault scarps approximately parallel to the axis of the Japan Trench. Relocated aftershocks show a band of genuine shallow aftershocks parallel to the Japan Trench under the outer trench slope and a region of post-mainshock events landward of the trench axis that occur over roughly the same latitude range and are thought to be the result of stress transfer to the interplate thrust boundary following the normal-faulting rupture. Based on a combination of P-wave first motions and inversion of surface wave spectral amplitudes, we propose a normal-faulting focal mechanism (ϕ = 200°, δ = 61° and λ = 271°) and a seismic moment M0 = (7 ± 1) × 1028 dyn cm (Mw = 8.5). A wide variety of data, including the distribution of isoseismals, the large magnitudes (up to 8.9) proposed by early investigators before the standardization of magnitude scales, estimates of energy-to-moment ratios and the tentative identification of a T wave at Pasadena (and possibly Riverside), clearly indicate that this seismic source was exceptionally rich in high-frequency wave energy, suggesting a large apparent stress and a sharp rise time, and consistent with the behaviour of many smaller shallow normal-faulting earthquakes. Hydrodynamic simulations based on a range of possible sources consistent with the above

  1. Magnetotelluric Study on the Donan Geothermal Field, Southern Part of Hokkaido, Japan

    Hayakawa, M.; Mogi, T.


    We performed a MT study in the Donan geothermal field where deep seated hot granitic rocks are distributing as a source of geothermal resources. But no prominent fracture zone were found in this area. Imaging a fracture zone and clarifying geothermal reservoirs are purpose of the study. Quaternary volcanoes, such as Hokkaido Komagatake and Esan in the southern part, and Karibayama in the northern part, are situated in the surroundings of the Donan area, southwestern Hokkaido, Japan. Even though recent volcanic activity is not seen in the central part, geothermal gradient is high. The geological structure of this region is dominated by the movement of basement blocks aligning in the north-south, and folds and fractures have developed. Many hot springs and geothermal manifestations are seen in this region where called "Yakumo-Nigorikawa geothermal zone." The Mori geothermal power plant, located at south area, is operating in the Nigorikawa caldera formed about 12,000 years ago. Like Nigorikawa, the Yakumo area, located at the central part of the Donan area, have been thought as promising geothermal area, and many geothermal study were performed in the 1990th. Six drilling holes were excavated and they showed that hot granitic rock are distributing at around below 1000m depth, and temperature is higher than 200 degrees in this area. We carried out new magnetotelluric (MT) survey at 20 stations in the Yakumo area. We constructed 2-D and 3-D resistivity model with MT data. Because the anomalous phases exceeding 90 degree were seen in some sites at frequency less than 0.1Hz, we only used the data at frequency range of 320Hz and 0.1Hz in this study. We used Ogawa and Uchida (1996) as a 2D inversion and Han et al. (2008) that have applied approximate sensitivity, as 3D inversion respectively. From the resistivity models, the remarkable low resistivity zone extending from deep to shallower is seen at the center of the survey area, that is inclined from south to north. A

  2. Small repeating earthquakes activity and interplate quasi-static slips in the Hyuga-nada, SW Japan

    Yamashita, Y.; Shimizu, H.; Goto, K.


    The Hyuga-nada region, a high-angle subduction zone belong the Kyushu-Ryukyu arc, is one of the most seismically active area in Japan and earthquakes with magnitude from 6.5 to 7.5 usually occur at dozens of years interval. In this region, the Philippine Sea Plate (PHS) subducts northwestward beneath the Eurasian Plate (EU) at a rate of about 5cm/year [Seno et al. (1993)]. We detected small repeating earthquakes in and around the Hyuga-nada using waveform similarity based on Igarashi et al. (2003). We used about 20,000 earthquakes which occurred in and around the Hyuga-nada and magnitude range is more than 2.0 detected by SEVO, Kyushu University from 1994 to 2008. We identified about 1,000 small repeating earthquakes, and they were compiled 390 groups. Most of small repeating earthquakes occur near the plate boundary between the PHS and the EU. They do not distribute in large moment-release areas of large earthquakes, but they distribute in those areas surrounding them; these characteristics are also found in NE Japan [e.g. Igarashi et al. (2003); Uchida et al. (2003)]. We selected 145 groups of small repeating earthquakes occurring in the plate boundary based on focal mechanism analysis. Almost all of them distribute the southern side from 32.5N, which suggests that an interplate coupling is probably changing near 32.5N. This result is consistent with present study of interplate coupling in and around Hyuga-nada using a geodetic data by GPS observation [e.g., Nishimura et al. (1999)]. We also estimated interplate quasi-static slip rate distribution in the Hyuga-nada using small repeating earthquakes. The result shows that the slip rate of shallow side of plate boundary is relatively larger than deep side of that in the area of 31.3~32N. In the deep side, the Hyuga-nada earthquakes (Mw6.7) occurred in Dec. 1996. It suggests that the interplate coupling of deep side is stronger than that of shallow side. Acknowledgments: In this study, we have used the data of

  3. Strong Coupling Gauge Theories in LHC ERA

    Fukaya, H.; Harada, M.; Tanabashi, M.; Yamawaki, K.


    AdS/QCD, light-front holography, and the nonperturbative running coupling / Stanley J. Brodsky, Guy de Teramond and Alexandre Deur -- New results on non-abelian vortices - Further insights into monopole, vortex and confinement / K. Konishi -- Study on exotic hadrons at B-factories / Toru Iijima -- Cold compressed baryonic matter with hidden local symmetry and holography / Mannque Rho -- Aspects of baryons in holographic QCD / T. Sakai -- Nuclear force from string theory / K. Hashimoto -- Integrating out holographic QCD back to hidden local symmetry / Masayasu Harada, Shinya Matsuzaki and Koichi Yamawaki -- Holographic heavy quarks and the giant Polyakov loop / Gianluca Grignani, Joanna Karczmarek and Gordon W. Semenoff -- Effect of vector-axial-vector mixing to dilepton spectrum in hot and/or dense matter / Masayasu Harada and Chihiro Sasaki -- Infrared behavior of ghost and gluon propagators compatible with color confinement in Yang-Mills theory with the Gribov horizon / Kei-Ichi Kondo -- Chiral symmetry breaking on the lattice / Hidenori Fukaya [for JLQCD and TWQCD collaborations] -- Gauge-Higgs unification: Stable Higgs bosons as cold dark matter / Yutaka Hosotani -- The limits of custodial symmetry / R. Sekhar Chivukula ... [et al.] -- Higgs searches at the tevatron / Kazuhiro Yamamoto [for the CDF and D[symbol] collaborations] -- The top triangle moose / R. S. Chivukula ... [et al.] -- Conformal phase transition in QCD like theories and beyond / V. A. Miransky -- Gauge-Higgs unification at LHC / Nobuhito Maru and Nobuchika Okada -- W[symbol]W[symbol] scattering in Higgsless models: Identifying better effective theories / Alexander S. Belyaev ... [et al.] -- Holographic estimate of Muon g - 2 / Deog Ki Hong -- Gauge-Higgs dark matter / T. Yamashita -- Topological and curvature effects in a multi-fermion interaction model / T. Inagaki and M. Hayashi -- A model of soft mass generation / J. Hosek -- TeV physics and conformality / Thomas Appelquist -- Conformal

  4. EDITORIAL: Flexible OLEDs and organic electronics Flexible OLEDs and organic electronics

    Kim, Jang-Joo; Han, Min-Koo; Noh, Yong-Young


    as one of the best candidates for the purpose, and J K Jeong discusses their status and perspectives. Next, several excellent research articles on OFETs follow. In particular, Y-Y Noh et al introduce an interesting method to control charge injection in top-gated OFETs by insertion of various self-assembled monolayers in their paper entitled 'Controlling contact resistance in top-gate polythiophene-based field-effect transistors by molecular engineering'. We would like to thank all the authors for their contributions, which combine new results and profound overviews of the state of the art in flexible OLEDs and organic electronics areas; it is this combination that most often adds to the value of topical issues. Special thanks also go to the staff of IOP Publishing, particularly Ms Alice Malhador, for contributing to the success of this effort. In this special issue, many wonderful reviews and research articles provide a detailed overview of recent progress in OLEDs, OPVs and OFETs as well as a scientific understanding of the device physics with these materials. We sincerely believe this special issue is a timely publication and will give productive information to a broad range of readers. Flexible OLEDs and organic electronics Contents Thin film encapsulation for flexible AM-OLED: a review Jin-Seong Park, Heeyeop Chae, Ho Kyoon Chung and Sang In Lee Large-area OLED lightings and their applications J W Park, D C Shin and S H Park Controlling contact resistance in top-gate polythiophene-based field-effect transistors by molecular engineering Yong-Young Noh, Xiaoyang Cheng, Marta Tello, Mi-Jung Lee and Henning Sirringhaus Branched polythiophene as a new amorphous semiconducting polymer for an organic field-effect transistor Makoto Karakawa, Yutaka Ie and Yoshio Aso Influence of mechanical strain on the electrical properties of flexible organic thin-film transistors Fang-Chung Chen, Tzung-Da Chen, Bing-Ruei Zeng and Ya-Wei Chung Frequency operation of low

  5. Preface: Introductory Remarks: Linear Scaling Methods

    Bowler, D. R.; Fattebert, J.-L.; Gillan, M. J.; Haynes, P. D.; Skylaris, C.-K.


    problems, there was another important theme: extending functionality. The search for greater accuracy has given an implementation of density functional designed to model van der Waals interactions accurately as well as local correlation, TDDFT and QMC and GW methods which, while not explicitly O(N), take advantage of localisation. All speakers at the workshop were invited to contribute to this issue, but not all were able to do this. Hence it is useful to give a complete list of the talks presented, with the names of the sessions; however, many talks fell within more than one area. This is an exciting time for linear scaling methods, which are already starting to contribute significantly to important scientific problems. Applications to nanostructures and biomolecules A DFT study on the structural stability of Ge 3D nanostructures on Si(001) using CONQUEST Tsuyoshi Miyazaki, D R Bowler, M J Gillan, T Otsuka and T Ohno Large scale electronic structure calculation theory and several applications Takeo Fujiwara and Takeo Hoshi ONETEP:Linear-scaling DFT with plane waves Chris-Kriton Skylaris, Peter D Haynes, Arash A Mostofi, Mike C Payne Maximally-localised Wannier functions as building blocks for large-scale electronic structure calculations Arash A Mostofi and Nicola Marzari A linear scaling three dimensional fragment method for ab initio calculations Lin-Wang Wang, Zhengji Zhao, Juan Meza Peta-scalable reactive Molecular dynamics simulation of mechanochemical processes Aiichiro Nakano, Rajiv K. Kalia, Ken-ichi Nomura, Fuyuki Shimojo and Priya Vashishta Recent developments and applications of the real-space multigrid (RMG) method Jerzy Bernholc, M Hodak, W Lu, and F Ribeiro Energy minimisation functionals and algorithms CONQUEST: A linear scaling DFT Code David R Bowler, Tsuyoshi Miyazaki, Antonio Torralba, Veronika Brazdova, Milica Todorovic, Takao Otsuka and Mike Gillan Kernel optimisation and the physical significance of optimised local orbitals in the ONETEP code Peter

  6. Phenotype of the taurine transporter knockout mouse.

    Warskulat, Ulrich; Heller-Stilb, Birgit; Oermann, Evelyn; Zilles, Karl; Haas, Helmut; Lang, Florian; Häussinger, Dieter


    ; Liu et al., 1992; Ramamoorthy et al., 1994; Schloss et al., 1994; Smith et al., 1992; Uchida et al., 1992; Vinnakota et al., 1997; Yancey et al., 1975). Taurine is not incorporated into proteins. It is involved in cell volume regulation, neuromodulation, antioxidant defense, protein stabilization, stress responses, and via formation of taurine-chloramine in immunomodulation (Chapman et al., 1993; Green et al., 1991; Huxtable, 1992; Timbrell et al., 1995). On the basis of its functions, taurine may protect cells against various types of injury (Chapman et al., 1993; Green et al., 1991; Huxtable, 1992; Kurz et al., 1998; Park et al., 1995; Stapleton et al., 1998; Timbrell et al., 1995; Welch and Brown, 1996; Wettstein and Häussinger, 1997). In order to examine the multiple taurine functions, murine models have several intrinsic advantages for in vivo research compared to other animal models, including lower cost, maintenance, and rapid reproduction rate. Further, experimental reagents for cellular and molecular studies are widely available for the mouse. In particular, mice can be easily genetically manipulated by making transgene and knockout mice. This chapter focuses on the phenotype of the TAUT-deficient murine model (taut-/-; Heller-Stilb et al., 2002), which may help researchers elucidate the diverse roles of taurine in development and maintenance of normal organ functions and morphology.

  7. Osmium isotopes and the Upper Devonian "Kellwasser" event

    Brauns, M.


    at least for the studied localities: (I) The Os isotopic composition of all limestone and shale samples as well as separated biogenic/diagenetic rock components is very radiogenic. Even the conodonts reveal no obvious contribution of primitive Os supplied by extraterrestrial material, as would be expected when considering the meteoric impact theory. Thus, such an event at the Frasne/Famenne boundary appears to be highly improbable. (II) A drastic peak reflecting elevated Re, Os concentrations during the upper gigas subzone may point to an enhanced clastic input of upper crustal material to the Kellwasser sea. Brauns, M. (2001): A rapid, low-blank technique for the extraction of Osmium from geological samples. Chem. Geol. In press. Schindler, E. (1990): Die Kellwasser - Krise (hohe Frasne-Stufe, Ober-Devon). Diss. Göttingen. 116 S. Tagami, K. & Uchida, S. (2000): Separation of rhenium by an extraction chromatograpic resin for determination by inductively coupled plasma-mass-spectrometry. Anal. Chim. Acta. 405, 227-229.

  8. New production in the South China Sea

    CAI; Pinghe


    estuary, Acta Oceanologica Sinica (in Chinese), 1993, 15(4): 50-55.[12]Okubo, T., Furuyama, K., Sakanoue, M., Distribution of 228Ra in surface sea water of the east Indian Ocean, Geochimica Journal, 1979, 13: 201-206.[13]Moore, W. S., Oceanic concentrations of 228Ra, Earth and Planetary Science Letters, 1969, 17: 437-446.[14]Sakanoue, M., Okubo, T., Furuyama, K., 228Ra in sea water, in Isotope Marine Chemistry (eds. Goldberg, E. D., Horibe, Y., Saruhashi, K.), Tokyo: Uchida Rokakuho Publishing Co. Ltd, 1980.[15]Dunne, J. P., Murray, J. M., Rodier, M. et al., Export flux in the western and central equatorial Pacific: Zonal and temporal variability, Deep-Sea ResearchⅠ, 2000, 47: 901-936.[16]Diego-McGlone, M. L. S., Jacinto, G. S., Dupra, V. C. et al., A comparison of nutrient characteristic and primary produc-tivity in the Sulu Sea and South China Sea, Acta Oceanographica Taiwanica, 1999, 37(3): 219-229.[17]Emerson, S., Quay, P., Karl, D. et al., Experimental determination of organic carbon flux from open-ocean waters, Nature, 1997, 389: 951-954.

  9. An open-label study of algorithm-based treatment versus treatment-as-usual for patients with schizophrenia

    Hirano J


    Full Text Available Jinichi Hirano,1,2 Koichiro Watanabe,3 Takefumi Suzuki,1,4 Hiroyuki Uchida,1 Ryosuke Den,5 Taishiro Kishimoto,1 Takashi Nagasawa,5 Yusuke Tomita,4 Koichiro Hara,6 Hiromi Ochi,7 Yoshimi Kobayashi,1 Mutsuko Ishii,1 Akane Fujita,1 Yoshihiko Kanai,1 Megumi Goto,1 Hiromi Hayashi,1 Kanako Inamura,1 Fumiko Ooshima,1 Mariko Sumida,1 Tomoko Ozawa,1 Kayoko Sekigawa,1 Maki Nagaoka,1 Kae Yoshimura,1 Mika Konishi,1 Ataru Inagaki,1 Takuya Saito,8 Nobutaka Motohashi,9 Masaru Mimura,1 Yoshiro Okubo,8 Motoichiro Kato,11Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 2Ohizumi Hospital, Tokyo, Japan; 3Department of Psychiatry School of Medicine, Kyorin University, Tokyo, Japan; 4Inokashira Hospital, Tokyo, Japan; 5Komagino Hospital, Tokyo, Japan; 6Asai Hospital, Chiba, Japan; 7Kurumegaoka Hospital, Tokyo, Japan; 8Department of Psychiatry School of Medicine, Nippon Medical School, Tokyo, Japan; 9Department of Psychiatry, School of Medicine, University of Yamanashi, Yamanashi, JapanObjective: The use of an algorithm may facilitate measurement-based treatment and result in more rational therapy. We conducted a 1-year, open-label study to compare various outcomes of algorithm-based treatment (ALGO for schizophrenia versus treatment-as-usual (TAU, for which evidence has been very scarce.Methods: In ALGO, patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, fourth edition were treated with an algorithm consisting of a series of antipsychotic monotherapies that was guided by the total scores in the positive and negative syndrome scale (PANSS. When posttreatment PANSS total scores were above 70% of those at baseline in the first and second stages, or above 80% in the 3rd stage, patients proceeded to the next treatment stage with different antipsychotics. In contrast, TAU represented the best clinical judgment by treating psychiatrists.Results: Forty-two patients (21 females, 39.0 ± 10.9 years

  10. Acute effects of power and resistance exercises on hemodynamic measurements of older women

    Coelho-Júnior HJ


    Full Text Available Hélio José Coelho-Júnior,1,2 Maria-Cláudia Irigoyen,3 Samuel da Silva Aguiar,2,4 Ivan de Oliveira Gonçalves,2,5 Niels Olsen Saraiva Câmara,6 Marco Antonio Cenedeze,7 Ricardo Yukio Asano,2,8 Bruno Rodrigues,1 Marco Carlos Uchida1 1Applied Kinesiology Laboratory–LCA, School of Physical Education, University of Campinas, Barão Geraldo, Campinas, São Paulo, 2Center of Health Sciences, University of Mogi das Cruzes, Mogi das Cruzes, 3Hypertension Unit, Heart Institute (InCor, Medical School of University of São Paulo, 4School of Physical Education, Catholic University of Brasília, Águas Claras, Brasília, 5Community Center for Older People of Poá, Poá, 6Department of Immunobiology, Laboratory of Transplantation Immunology, Institute of Biomedical Sciences, University of São Paulo, 7Nephrology Division, Federal University of São Paulo, 8School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil Purpose: The purpose of this study was to compare the acute effects of resistance training (RT and power training (PT on the hemodynamic parameters and nitric oxide (NO bioavailability of older women. Materials and methods: A randomized experimental design was used in this study. Twenty-one older women (age: 67.1±4.6 years; body mass index: 28.03±4.9 kg/m2; systolic blood pressure: 135.1±21.1 mmHg were recruited to participate in this study. Volunteers were randomly allocated into PT, RT, and control session (CS groups. The PT and RT groups underwent a single session of physical exercise equalized by training volume, characterized by 3 sets of 8–10 repetitions in 8 different exercises. However, RT group performed exercise at a higher intensity (difficult than PT (moderate group. On the other hand, concentric contractions were faster in PT group than in RT group. Hemodynamic parameters and saliva samples (for NO quantification were collected before and during an hour after exercise completion. Results: Results

  11. PREFACE: Tenth International Conference on Topics in Astroparticle and Underground Physics (TAUP2007)

    Inoue, Kunio; Suzuki, Atsuto; Mitsui, Tadao


    The tenth meeting of the TAUP Workshop Series, TAUP 2007, was organized by the Research Center for Neutrino Science, Tohoku University. In TAUP 2007 all the various aspects of Astroparticle Physics have been covered, from Cosmology and Dark Constituents, to Gravitational Waves, to Neutrino Physics and Astrophysics, to High Energy Astrophysics, to Cosmic Rays and Gamma-Rays Astronomy. New and important scientific results were presented and debated in the plenary review talks and in a very large number of contributions in topical parallel sessions. As editors of these proceedings, we hope that this volume, which contains most of the talks and contributions presented at TAUP 2007, will provide a detailed state-of-the-art account of the various facets of Astroparticle Physics. We thank all the invited speakers, conveners, and contributors who made this possible. Full coverage of the transparencies presented at the conference can be found on the website The TAUP 2007 Organizing Committee thanks IUPAP/PaNAGIC, Sendai Tourism and Convention Bureau, COE program: Exploring New Science by Bridging Particle-Matter Hierarchy, SEIKO EG&G, and REPIC corporation for sponsoring the Conference, and Sendai Civic Auditorium, where the meeting was held, for their hospitality. We wish to thank Alessandro Bottino, Junpei Shirai, Fumihiko Suekane, David Sinclair, Takaaki Kajita, Takeo Moroi, Masaki Mori, Masahiro Kawasaki, Yoshihito Gando, Sei Yoshida, Kyoko Tamae, Sanshiro Enomoto, Alexandre Kozlov, Yasuhiro Kishimoto, Itaru Shimizu, Kengo Nakamura, Haruo Ikeda, and Kyo Nakajima for their invaluable contribution in the scientific shaping of the conference and in the preparation of the present volume. The Organizing Committee is grateful to the members of the International Advisory Committee and of the TAUP Steering Committee for assistance and advice on the scientific program. Very special thanks are due to Ms Rika Bizen, Mr Fujio Miura, Ms Akemi

  12. [Preventive measures against tuberculosis in working facilities and companies].

    Suzuki, Kiminori; Satou, Ken


    IMOTO (Taito Health Center, Tokyo) and Toru MORI (Research Institute of Tuberculosis, JATA). We surveyed environmental conditions in working places and domestic conditions of employees who were working for small-sized companies located in Taito ward, based on written questionnaires. The companies were selected as those which had the patients of tuberculosis in the past one-year period, and the number of employees was less than ten. Compared with control people, TB patients had more frequent smoking habit (p periodical or extraperiodical health check-up. We retrospectively analyzed some medical factors contributing to successful treatment of the disease. Hospital admission and enhancement of counseling opportunities were two factors leading to the success of the treatment. The ambulance attendants have a significant possibility to contact patients with TB and are high at risk of acquiring the infection. As there are often limited information on TB in patients in an emergency condition, it is difficult to protect themselves from its contagion properly. Periodical and extraperiodical health check-up is important for these personnel and application of QuantiFERON-TB 2nd generation to the personnel is new and useful for diagnosis of the latent tuberculosis infection. 5. A role of chest X-ray examination for lung cancer detection among company workers: Takeo TESHIMA (Koseikan Clinic, Miyagi Branch, Japan Anti-Tuberculosis Association). Detection rates of lung cancer in company workers and in general population under the age of 60 years were compared. Chest X-ray survey was done using 10 cm x 10 cm indirect chest X-ray films of the chest. The detection rates of lung cancer in patients with definite or suspicious diagnosis in 265,620 company workers were 2.3 and 2.6 per 100,000, respectively. On the other hand the rates were 9.9 and 8.8 per 100,000 in a general population of 811,391. Twenty-four percent of patients with suspicious diagnosis were eventually made a definite

  13. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji


    . Lectures and poster presentations were thus solicited from leading international academic and industrial researchers. The large audience that attended responded to the high quality of the talks with pertinent questions and lively discussions. The third workshop, TMI2009, was held over three days from 11-13 November, 2009, at the Nagoya International Center, Nagoya, Japan. Invited talks were given by 23 speakers from 9 countries from both the academic and industry sectors. The speakers were Ryoji Asahi (Toyota Central R&D Labs, Japan), Tomas Bucko (University of Vienna, Austria), Gábor Csányi (University of Cambridge, UK), Alessandro De Vita (King's College London, UK), Bernard Delley (Paul Scherrer Institute, Switzerland), Christophe Domain (EDF, France), George Fitzgerald (Accelrys, USA), Takeo Fujiwara (University of Tokyo, Japan), Jürgen Hafner (University of Vienna, Austria), Masaya Ishida (Sumitomo Chemicals, Japan), Werner Janse Van Rensburg (Sasol Technology, South Africa), Masanori Kohyama (AIST, Japan), Takao Kotani (Tottori University, Japan), Georg Kresse (University of Vienna, Austria), Katsuyuki Matsunaga (Kyoto University, Japan), Stefan Müller (University of Erlangen-Nuremberg, Germany), Shin-ichiro Nakamura (Mitsubishi Chemicals, Japan), Fumiyasu Oba (Kyoto University, Japan), Tamio Oguchi (Hiroshima University, Japan), Pascal Raybaud (IFP, France), Isao Tanaka (Kyoto University/JFCC, Japan), Göran Wahnström (Chalmers University of Technology, Sweden), and Erich Wimmer (Materials Design Inc., USA). There were 40 poster presentations in total. The workshop was attended by approximately 120 participants with approximately 50 per cent from industry. The invited talks covered advances in ab initio solid-state calculations and their practical use in industry. Presentations outlining the progress made in treating large and complex systems, as well as more accurate and efficient calculation methods, were given from the theory side. Examples of the use of ab

  14. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010)

    Takahashi, M.; Saito, H.


    Yanagihara, Yuta Toyoda and Eiji Kita Monte Carlo simulations of the magnetocaloric effect in magnetic Ni-Mn-X (X = Ga, In) Heusler alloys V D Buchelnikov, V V Sokolovskiy, S V Taskaev, V V Khovaylo, A A Aliev, L N Khanov, A B Batdalov, P Entel, H Miki and T Takagi Changes in electronic states and magnetic free energy in La1-zCez(FexSi1-x)13 magnetic refrigerants A Fujita, S Fujieda and K Fukamichi Garnet composite films with Au particles fabricated by repetitive formation for enhancement of Faraday effect H Uchida, Y Mizutani, Y Nakai, A A Fedyanin and M Inoue Control of magnetic domain wall displacement using spin current in small in-plane magnetic field in Permalloy nanowires Yoshihiko Togawa, Takashi Kimura, Ken Harada, Akira Tonomura and Yoshichika Otani Magnetic-field tunable transmittance in a ferrofluid-filled silicon nitride photonic crystal slab H M Lee, L Horng and J C Wu Evaluation of a miniature magnetostrictive actuator using Galfenol under tensile stress Toshiyuki Ueno, Hidemitsu Miura and Sotoshi Yamada Sub-nm resolution depth profiling of the magnetic structure of thin films by the depth-resolved x-ray magnetic circular dichroism technique K Amemiya and M Sakamaki

  15. A baseline analysis of the distribution, host-range, and severity of the rust Puccinia Psidii in the Hawaiian islands, 2005-2010

    Anderson, Robert C.


    westward. Although possibly present earlier, P. psidii was found in California in November 2005 in a nursery in San Diego County on Myrtus communis and documented by a report in a nursery newsletter (Mellano 2006). Puccinia psidii was first found in Hawai`i on a young plant of `ōhi`a (Metrosideros polymorpha) in April 2005, in a nursery on the island of O`ahu (Killgore and Heu 2005; Uchida et al. 2006). The fungus subsequently spread to most islands of the Hawaiian chain, infecting `ōhi`a and other myrtaceous hosts (Hauff 2006, Anderson et al. 2007). P. psidii was first found in Japan in May 2007 on cultivated `ōhi`a (Kawanishi et al. 2009). Most recently, a rust identified as Uredo rangelii was discovered in April 2010 in New South Wales, Australia (Carnegie et al. 2010). This rust is closely related to Puccinia psidii and is part of the guava rust complex described by Simpson et al. (2006). Although treated as a separate species by Simpson et al. (2006), many authors now consider U. rangelii a synonym for U. psidii, which is the anamorph (asexual stage) of P. psidii, and therefore, the same species (Glen et al. 2007, Carnegie et al. 2010). Because of the large diversity of native Myrtaceae present in Australia, the number of Myrtaceae hosts attacked by species of the guava rust complex will likely grow now that U. rangelii has arrived and is spreading in the country. As of this writing (June 2011), 94 species of Myrtaceae have been identified as hosts of U. rangelii in the states of New South Wales and Queensland. Damage is severe on nearly one-third of the species affected, and 16 of these species are threatened or endangered native species (Secretary of Australia, May 2011). The presence of Puccinia psidii in Hawai`i is particularly alarming for at least two reasons: (1) M. polymorpha is the dominant overstory tree of the native forest, and (2) P. psidii is now established in the Pacific region, where numerous Myrtaceae species are native. Native ecosystems in Hawai

  16. EDITORIAL: Northern Hemisphere high latitude climate and environmental change

    Groisman, Pavel; Soja, Amber


    Chang and Won-Tae Kwon Land cover and land use Responses of the circumpolar boreal forest to 20th century climate variability Andrea H Lloyd and Andrew G Bunn The biogeochemical cycle and its feedbacks Sphagnum peatland development at their southern climatic range inWest Siberia: trends and peat accumulation patterns Anna Peregon, Masao Uchida and Yasuyuki Shibata Methane emissions from western Siberian wetlands: heterogeneity and sensitivity to climate change T J Bohn, D P Lettenmaier, K Sathulur, L C Bowling, E Podest, K C McDonald and T Friborg The cryosphere Potential feedback of thawing permafrost to the global climate system through methane emission O A Anisimov Glacier changes in the Siberian Altai Mountains, Ob river basin, (1952 2006) estimated with high resolution imagery A B Surazakov, V B Aizen, E M Aizen and S A Nikitin Human dimensions Food and water security in a changing arctic climate Daniel M White, S Craig Gerlach, Philip Loring, Amy C Tidwell and Molly C Chambers

  17. EDITORIAL: Ongoing climatic change in Northern Eurasia: justification for expedient research

    Groisman, Pavel; Soja, Amber J.


    Russia A Olchev, E Novenko, O Desherevskaya, K Krasnorutskaya and J Kurbatova The effects of climate, permafrost and fire on vegetation change in Siberia in a changing climate N M Tchebakova, E Parfenova and A J Soja An image-based inventory of the spatial structure of West Siberian wetlands A Peregon, S Maksyutov and Y Yamagata Modeling of the carbon dioxide fluxes in European Russia peat bogs J Kurbatova, C Li, F Tatarinov, A Varlagin, N Shalukhina and A Olchev Feedbacks of windthrow for Norway spruce and Scots pine stands under changing climate O Panferov, C Doering, E Rauch, A Sogachev and B Ahrends Reconstruction and prediction of climate and vegetation change in the Holocene in the Altai-Sayan mountains, Central Asia N M Tchebakova, T A Blyakharchuk and E I Parfenova Simulating the effects of soil organic nitrogen and grazing on arctic tundra vegetation dynamics on the Yamal Peninsula, Russia Qin Yu, Howard Epstein and Donald Walker Possible decline of the carbon sink in the Mongolian Plateau during the 21st century Y Lu, Q Zhuang, G Zhou, A Sirin, J Melillo and D Kicklighter The frequency of forest fires in Scots pine stands of Tuva, Russia G A Ivanova, V A Ivanov, E A Kukavskaya and A J Soja Lateral extension in Sphagnum mires along the southern margin of the boreal region, Western Siberia A Peregon, M Uchida and Y Yamagata Evaluating the sensitivity of Eurasian forest biomass to climate change using a dynamic vegetation model J K Shuman and H H Shugart Studies of socioeconomic processes in Northern Eurasia Comparing patterns of ecosystem service consumption and perceptions of range management between ethnic herders in Inner Mongolia and Mongolia L Zhen, B Ochirbat, Y Lv, Y J Wei, X L Liu, J Q Chen, Z J Yao and F Li Land cover/land use change in semi-arid Inner Mongolia: 1992-2004 Ranjeet John, Jiquan Chen, Nan Lu and Burkhard Wilske Spatial and temporal patterns of greenness on the Yamal Peninsula, Russia: interactions of ecological and social factors affecting