Sample records for yoshihiko ohama makoto

  1. Mucosal cytokine network in inflammatory bowel disease Akira Andoh,Yuhki Yagi,Makoto Shioya,Atsushi Nishida,Tomoyuki Tsujikawa,Yoshihide Fujiyama Akira Andoh,Yuhki Yagi,Makoto Shioya,

    Atsushi Nishida; Tomoyuki Tsujikawa; Yoshihide FUjiyama; Yuhki Yagi; Makoto Shioya; Akira Andoh


    Inflammatory bowel disease(IBD),ulcerative colitis(UC)and Crohn's disease(CD)are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved.The chronic inflammatory process leads to disruption of the epithelial barrier,and the fcIrmation of epithelial ulceration.This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina propria,and stimulates further pathological immune cell responses.Cytokines are essential mediators of the interactions between activated immune cells and nonimmune cells,including epithelial and mesenchymal cells.The clinicaI efficacy of targeting TNF-α clearly indicates that cytokines are the therapeutic targets in IBD patients.In this manuscript,we focus on the biological activities of recently-reported cytokines[Inter-leukin(IL)-17 cytokine family,IL-31 and IL-32],which might play a role through interaction with TNF-α in the pathophysiology of IBD.(C)2008 The WJG Press.All rights reserved.

  2. Effects of Oxidized Low Density Lipoprotein and Native LDL on Low Shear-Induced Platelet Aggregation(Special Issue in Hornor of the Retirement of Professor Makoto Iwata at the Department of Neurology, Tokyo Women's Medical University)

    矢野, 知佐子; 山崎, 昌子; 内山, 真一郎; 岩田, 誠; YANO, Chisako; YAMAZAKI, Masako; UCHIYAMA, Shinichiro; IWATA, Makoto


    Oxidized LDL (ox-LDL) is known to be closely associated with atherosclerosis, and it is one of the sources of oxidized cellular injury. Previous studies show that ox-LDL affects platelet aggregation. We studied the effects of ox-LDL on shear-induced platelet aggregation (SIPA) and compared it with native LDL. Methods: We incubated ox-LDL with LDL and CuSO_4 for 16 hours at 37℃. We incubated platelet-rich plasma (PRP) with ox-LDL or native LDL, and measured SIP A. And we compared the effect of...

  3. Will Noda Shift Japan’s China Policy?


    Better ties with China could help Japan’s economic recovery The Japanese political merrygo -round has spun out yet another new prime minister. On August 30, Yoshihiko Noda replaced Nao to Kan to become Japan’s third prime minister in the last two years and sixth in the last five years. Observers are

  4. The redistributive consequences of monetary policy

    Nakajima, Makoto


    Monetary policy is not intended to benefit one segment of the population at the expense of another by redistributing income and wealth. But as Makoto Nakajima explains, it is probably impossible to avoid such redistributive consequences.

  5. Effects of Azelnidipine plus OlmesaRTAn versus amlodipine plus olmesartan on central blood pressure and left ventricular mass index: the AORTA study

    Takami T; Saito Y.


    Takeshi Takami1, Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, JapanPurpose: The aim of this study was to compare the effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP) and left ventricular mass index (LVMI) in hypertensive patients.Patient and methods: Patients with brachial systolic BP ≥ 140 mmHg and/or diastolic BP &...

  6. Perceived parental affectionless control is associated with high neuroticism

    Takahashi N; Suzuki A; Matsumoto Y; Shirata T; Otani K


    Nana Takahashi, Akihito Suzuki, Yoshihiko Matsumoto, Toshinori Shirata, Koichi Otani Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan Objective: Depressed patients are prone to perceive that they were exposed to affectionless control by parents. Meanwhile, high neuroticism is a well-established risk factor for developing depression. Therefore, this study examined whether perceived parental affectionless control is associated with high neuroticism.Methods: Th...

  7. Effect of Modified Polymer on Crack Resistance of Mortar


    At present, the basic technical principle in China is to adopt polymers to modifying the properties of mortar so as to improve the crack-resistance of construction structures and to strengthen their water-resisting and climate-resisting properties as well. However, how polymer acts on anti-crack mortar is short of systematic research. Theoretical exposition of polymer mortar is basically explained by Ohama Model, which is cement slaking and polymer coating are carried on together and mutually-cross web structure interweaved with liquid and polymer coating. But anti-crack mortar has its own special characteristics because of fewer polymers mixed in it and its high viscosity. So this paper is to showing how different polymers affect its crack-resistance cannot be reflected from this theory. Vinyl-acetate ethylene (VAC/E) has been selected as representation of polymerization, whose property is modified by compounding it from some inorganic components, such as talc, CaCO3 and so on. And then the mechanics property and shrinkage of anti-crack polymer mortar is tested when different amount of polymers is added as admixture of mortar. The result indicates that, the working performance and mechanics property of the polymer mortar are worse mixed VAC/E only. It basically meets the demands for mechanics strength and working performance when mixed both VAC/E and CaCO3. While it achieves much better mechanical property and working performance than the two former when mixed VAC/E,talc and CaCO3; the result of corresponding scanning electron microscopy (SEM) of sample indicates that the internal result of the polymer mortar, compared with classical Ohama Model, has a particularity that its structure is formed by polymer coating instead of filling up the intervals among cement grains.

  8. Stemcell Information: SKIP000145 [SKIP Stemcell Database[Archive

    Full Text Available ... Makoto Otsu --Huan-Ting Lin 大津 真--Huan-Ting Lin University of Tokyo, Institute of Medical Science--Un...iversity of Tokyo, Institute of Medical Science 東京大学医科学研究所--東京大学医科学研究所 University... of Tokyo, Institute of Medical Science 東京大学医科学研究所 Makoto Otsu 大津 真 Not Available Riken BRC 理研BRC ...

  9. Stemcell Information: SKIP000144 [SKIP Stemcell Database[Archive

    Full Text Available ... Makoto Otsu --Huan-Ting Lin 大津 真--Huan-Ting Lin University of Tokyo, Institute of Medical Science--U...niversity of Tokyo, Institute of Medical Science 東京大学医科学研究所--東京大学医科学研究所 Universit...y of Tokyo, Institute of Medical Science 東京大学医科学研究所 Makoto Otsu 大津 真 Not Available Riken BRC 理研BRC ...

  10. Physiological and Psychological Characteristics of Successful Combat Controller Trainees


    heart rate (bpm), maximal respiratory exchange ratio (RER), and run- ning economy ( Relative, absolute, and run- ning economy VO2 max per minute while max RER values ranged from 1.12 to 1.38. Table 3 displays means and standard deviations for the Makoto proactive reaction time

  11. Database Description - Plabrain DB | LSDB Archive [Life Science Database Archive metadata

    Full Text Available ra, Tomomi Kudome, Osamu Nishimura, Hiroshi Tarui and Kiyokazu Agata Journal: Dev Growth Differ., 52, 131-14...ashi Taniguchi and Kiyokazu Agata Journal: Neuroscience, 168, 18-30 (2010) External Links: Article title: Pl...em Author name(s): Hiroyuki Takeda, Kaneyasu Nishimura and Kiyokazu Agata Journal: Zoolog. Sci., 26, 805-813...Takeshi Inoue, Yoshihiko Umesono, Kanji Yoshimoto, Takashi Taniguchi and Kiyokazu Agata Journal: Dev Growth ...Takashi Taniguchi and Kiyokazu Agata Journal: Neurosci. Res., 59, 101-106 (2007)

  12. Japan. Ogata, 4 others to get Order of Culture


    Makoto Ooka, 72, known for his comments on haiku and tanka poetry; Matazo Kayama, 76, for reviving traditional Japanese painting; Kazuhiko Nishijima, 77, professor emeritus at both the University of Tokyo and Kyoto University, in recognition of his contribution in the field of elementary particle physics (his classification of elementary particles became the basis of quark theory); and Wataru Mori, 77, professor emeritus at the University of Tokyo for his contribution to the study of pathology (1/2 page).

  13. ONR (Office of Naval Research) Far East Scientific Information Bulletin. Volume 14, Number 3, July-September 1989


    Masahiro Yoshimura Tokyo Institute of Technology Preparation of Mullite Kenya Hamano Kanagawa University Ceramics from Kaolin Hiroaki Nakajima and... Kaolin Hiromichi Ichinose Sachiko Furuta Shuji Yoshida Makoto Egashita Nagasaki University Microstructure and Mechanical Teruhiko Kinoshita Tokyo...cutting angle error and they tures, are thought to be less sensitive to can be grown from a congruent melt, but sulphur . they grow only at 2.5 mm/h

  14. Hangout With CERN: Antimatter (S01E05)

    Kahle, Kate


    In this hangout we delve into the world of antimatter. How is it different from matter? What antimatter research is going on at CERN? Why? What have we learned so far and what will this research lead to? ATLAS physicist Steven Goldfarb is joined by CERN theorist Alex Arbey, Seth Zenz from the CMS experiment, and Michael Doser, Makoto Fujiwara and Masaki Hori from the antimatter experiments at CERN.Recorded live on 29th November 2012.

  15. 2007 Chinese and Japanese Businessmen’s Friendly Spring-Greeting Party Held in Beijing


    <正>On the evening of March 22, the China-Japan Friendship Association (CJFA) and the Japanese Chamber of Commerce in China (JCCC) held the 2007 Chinese and Japanese Businessmen ’ s Friendly Spring-Greeting Party at the Hotel New Otani Chang Fu Gong in Beijing. Song Jian, president of the CJFA, Makoto Isogai, president of the JCCC, and Yuji Miyamoto, Japanese ambassador to China, other diplomats of the

  16. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

    Miyazaki M; Nakamura H; Takahashi S; Chubachi S; Sasaki M.; Haraguchi M; Terai H; Ishii M; Fukunaga K; Tasaka S; Soejima K; Asano K.; Betsuyaku T


    Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR) group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medici...

  17. Jaapani graafika Tallinnas


    Ku galeriis jaapani kaasaegse graafika näitus "Living Faces in Tallinn". Kouichi Kitamura kujundatud väljapanek tutvustab rühmituse Printsaurus kunstnike töid. Adamson-Ericu muuseumis näitus "300 aastat Jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". 12. ja 13 IX esinevad näitusel Keizo Sato, tema assistent Makoto Nakayama, puulõikemeister Hiroshi Fujizawa ja ukiyo-e uurija kunstnik Tuula Moilanen. 12. IX loengud "Ukiyo-e puulõike maailm", 13. IX esitletakse ukiyo-e puulõiketehnikat

  18. Stemcell Information: SKIP000278 [SKIP Stemcell Database[Archive

    Full Text Available man bFGF ... Negative ... Yes ... Natsumi Shimizu 清水 なつみ RIKEN BioResource Center 理化学研究所バイオリソースセンタ...ー RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Available--Avai...lable--Available RIKEN BioResource Center--Makoto Yazaki(Nagoya City University)--iPS Academia Japan,Inc. 理化学

  19. Jaapani graafika Tallinnas


    Ku galeriis jaapani kaasaegse graafika näitus "Living Faces in Tallinn". Kouichi Kitamura kujundatud väljapanek tutvustab rühmituse Printsaurus kunstnike töid. Adamson-Ericu muuseumis näitus "300 aastat Jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". 12. ja 13 IX esinevad näitusel Keizo Sato, tema assistent Makoto Nakayama, puulõikemeister Hiroshi Fujizawa ja ukiyo-e uurija kunstnik Tuula Moilanen. 12. IX loengud "Ukiyo-e puulõike maailm", 13. IX esitletakse ukiyo-e puulõiketehnikat

  20. Limit Theorems for Functionals of Markov Processes and Renormalizable Stable Fields


    g(xl,Yl) ... g(xk,yk), 92(a,x) = g2 (a1, x).. .g 2 (ak,-k) (13) (see Feldman and Rachev , 1993), we restrict our parameter set to functions from the...authors would like to thank Svetlozar Rachev for helpful discussions of stable distributions and processes. We would like to thank Makoto Maejima for...limit theorems for functionals of the Brownian sheet, Annals of Probability, 17, 538-558. Feldman, R.E. and Rachev , S.T. (1993), U-statistics of random

  1. Examination of a pre-exercise, high energy supplement on exercise performance

    Tranchina Christopher P


    Full Text Available Abstract Background The purpose of this study was to examine the effect of a pre-exercise high energy drink on reaction time and anaerobic power in competitive strength/power athletes. In addition, the effect of the pre-exercise drink on subjective feelings of energy, fatigue, alertness and focus was also explored. Methods Twelve male strength/power athletes (21.1 ± 1.3 y; 179.8 ± 7.1 cm; 88.6 ± 12.1 kg; 17.6 ± 3.3% body fat underwent two testing sessions administered in a randomized and double-blind fashion. During each session, subjects reported to the Human Performance Laboratory and were provided with either 120 ml of a high energy drink (SUP, commercially marketed as Redline Extreme® or 120 ml of a placebo (PL that was similar in taste and appearance but contained no active ingredients. Following consumption of the supplement or placebo subjects rested quietly for 10-minutes prior to completing a survey and commencing exercise. The survey consisted of 4 questions asking each subject to describe their feelings of energy, fatigue, alertness and focus for that moment. Following the completion of the questionnaire subjects performed a 2-minute quickness and reaction test on the Makoto testing device (Makoto USA, Centennial CO and a 20-second Wingate Anaerobic Power test. Following a 10-minute rest subjects repeated the testing sequence and after a similar rest period a third and final testing sequence was performed. The Makoto testing device consisted of subjects reacting to both a visual and auditory stimulus and striking one out of 30 potential targets on three towers. Results Significant difference in reaction performance was seen between SUP and PL in both average number of targets struck (55.8 ± 7.4 versus 51.9 ± 7.4, respectively and percent of targets struck (71.9 ± 10.5% versus 66.8 ± 10.9%, respectively. No significant differences between trials were seen in any anaerobic power measure. Subjective feelings of energy (3.5 ± 0

  2. Perceived parental affectionless control is associated with high neuroticism

    Takahashi N


    Full Text Available Nana Takahashi, Akihito Suzuki, Yoshihiko Matsumoto, Toshinori Shirata, Koichi Otani Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan Objective: Depressed patients are prone to perceive that they were exposed to affectionless control by parents. Meanwhile, high neuroticism is a well-established risk factor for developing depression. Therefore, this study examined whether perceived parental affectionless control is associated with high neuroticism.Methods: The subjects were 664 healthy Japanese volunteers. Perceived parental care and protection were assessed by the Parental Bonding Instrument. Parental rearing was categorized into either optimal parenting (high care/low protection or three dysfunctional parenting styles including affectionless control (low care/high protection. Neuroticism was evaluated by the NEO Personality Inventory-Revised.Results: The subjects with paternal affectionless control had higher neuroticism scores than those with paternal optimal parenting. Similar tendency was observed in maternal rearing. Neuroticism scores increased in a stepwise manner with respect to the increase in the number of parents with affectionless control.Conclusion: The present study shows that perceived parental affectionless control is associated with high neuroticism, suggesting that this parental style increases neuroticism in recipients. Keywords: parenting, attachment, personality, vulnerability, depression, PBI, NEO PI-R

  3. Séminaire de probabilités XLVIII

    Lejay, Antoine; Rouault, Alain


    In addition to its further exploration of the subject of peacocks, introduced in recent Séminaires de Probabilités, this volume continues the series’ focus on current research themes in traditional topics such as stochastic calculus, filtrations and random matrices. Also included are some particularly interesting articles involving harmonic measures, random fields and loop soups. The featured contributors are Mathias Beiglböck, Martin Huesmann and Florian Stebegg, Nicolas Juillet, Gilles Pags, Dai Taguchi, Alexis Devulder, Mátyás Barczy and Peter Kern, I. Bailleul, Jürgen Angst and Camille Tardif, Nicolas Privault, Anita Behme, Alexander Lindner and Makoto Maejima, Cédric Lecouvey and Kilian Raschel, Christophe Profeta and Thomas Simon, O. Khorunzhiy and Songzi Li, Franck Maunoury, Stéphane Laurent, Anna Aksamit and Libo Li, David Applebaum, and Wendelin Werner. .

  4. Some connectedness problems in positively curved Finsler manifolds

    Peter, Ioan Radu


    This paper studies some connectedness problems under the positivity hypothesis of various curvatures ( k-Ricci and flag curvature). Our approach uses Morse Theory for general end conditions (see [Ioan Radu Peter, The Morse index theorem where the ends are submanifolds in Finsler geometry, Houston J. Math. 32 (4) (2006) 995-1009]). Some previous results related to the flag curvature were obtained in [Ioan Radu Peter, A connectedness principle in positively curved Finsler manifolds, in: H. Shimada, S. Sabau (Eds.), Advanced Studies in Pure Mathematics, Finsler Geometry, Sapporo 2005-In Memory of Makoto Matsumoto, Mathematical Society of Japan, 2007]. Some results from Riemannian geometry are extended to the Finsler category also. The Finsler setting is much more complicated and the difference between Finsler and Riemann settings will be emphasized during the paper.

  5. Paraneoplastic retinopathy associated with retroperitoneal liposarcoma

    Mineo Kondo


    Full Text Available Mineo Kondo1, Kumiko Mokuno2, Ai Uemura1, Shu Kachi1, Makoto Nakamura1, Atsuya Kondo3, Hiroko Terasaki11Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2Department of Ophthalmology, 3Department of Urology, Kariya Toyota General Hospital Kariya, JapanAbstract: We report a case of paraneoplastic retinopathy associated with a retroperitoneal liposarcoma. A 42-year-old man was referred to our hospital with complaints of night blindness and blurred vision in the peripheral field. Electroretinograms showed a progressive amplitude reduction in his both eyes. Abdominal magnetic resonance imaging showed a large retroperitoneal mass, and pathologic examination revealed a dedifferentiated liposarcoma. Western blot analysis showed an antiretinal antibody in the serum of our patient, and his serum reacted with the photoreceptors of a bovine retina. To the best of our knowledge, this is the first case of paraneoplastic retinopathy associated with a liposarcoma.Keywords: paraneoplastic retinopathy, retroperitneal liposarcoma, electroretinogram, cancerassociated retinopathy

  6. Hemorrhagic infarction at 33 days after birth in a healthy full-term neonate

    Kubo Y


    Full Text Available Yoshitaka Kubo1, Kuniaki Ogasawara1, Akira Kurose2, Hiroshi Kashimura1, Takahiro Koji1, Yasunari Otawara1, Jun Kamei3, Manami Akasaka3, Makoto Sasaki4, Akira Ogawa1 1Department of Neurosurgery, 2Department of Pathology, 3Department of Pediatrics, 4Department of Radiology, Iwate Medical University, Morioka, Japan Abstract: Intraparenchymal hemorrhage in the full-term neonate rarely occurs more than 2 weeks after birth, and its definitive cause remains unclear. In the present report, a case of a patient with intraparenchymal hemorrhage occurring 33 days after birth is described. Histological examination of the brain tissue obtained during hematoma evacuation through craniotomy showed hemorrhagic infarction. Patent foramen ovale may have been present and this may have led to spontaneous paradoxical cerebral embolism followed by hemorrhagic infarction. Keywords: full-term neonate, hemorrhagic cerebral infarction, patent foramen ovale, surgery

  7. Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography

    Yamauchi Y


    Full Text Available Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activity

  8. A case of sebaceous adenoma of the eyelid showing excessively rapid growth

    Takayama K


    Full Text Available Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 3Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan Background: Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size. Case report: A 65-year-old man presented with a progressively enlarging exophytic lesion in the right eyelid for 3 months. External examination revealed a yellowish-pink growth measuring 18 × 13 × 14 mm. The lesion surface was covered by palpebral conjunctiva with fine papillary projections, vascularity, crusting, and ulceration. Two weeks later, the growth enlarged to 20 × 14 × 14 mm, and ulceration also expanded. An excisional biopsy with clear resection margins was performed. No malignancy was found in the stump. Histopathologically, the lesion was located principally within the cutaneous compartment and composed of multiple circumscribed sebaceous lobules, separated, and exhibiting no cytologic atypia. Cystic change was not evident, and no infiltrative growth pattern, pagetoid lesions, mitotic figures, and lymphovascular space invasion were observed. The Ki-67 nuclear antigen was detected in 10%–15% of cells located in the basal zone of the nodule. Fluorescence in situ hybridization showed low human epidermal growth factor receptor 2 amplification, suggesting no genetic changes. The clinical findings, lack of infiltrative border, low Ki-67 index, and low proliferative ability support a diagnosis of sebaceous adenoma. Conclusion: Sebaceous adenoma that shows excessively rapid growth due to hyperplasia may appear to be malignant. Histopathology, fluorescence in situ hybridization, and Ki-67 were useful to

  9. 民主党下野及日本政坛剧变的深层原因%On Underlying Reason of the Fall of DPJ and Japanese Political Upheaval



    The election result of Japan’s 46th House of Representatives had not only replayed the regime change three years and three months ago, but also put an end of “the major two parties holding office in rotation”. The direct causes of DPJ’s unprecedented defeat were the internal and external policy mistakes of leadership headed by Yoshihiko Noda and the failure of inner-party’s operations, and what should attract people’s more attention is the profound changes of Japan’s political ecology in recent years. If Japanese ruling and opposition parties cannot adapt to these changes to speed up their transformation, Japan’s political unrest will continue to last quite a long time.%  日本第46届众议院选举的结果,不仅重演了三年零三个月前朝野易位的一幕,也给“两大政党轮流执政制”划上了句号。民主党之所以遭到空前惨败,直接原因是以野田佳彦为首的领导层内外政策的失误和党内运作的失败,而更应该引起人们注意的是日本政治生态近年来发生的深刻变化。朝野政党如果不能顺应这些变化加快转型,日本政局的动荡局面还将延续相当长一段时间。

  10. What strategies do ulcerative colitis patients employ to facilitate adherence?

    Kawakami A


    Full Text Available Aki Kawakami,1,2 Makoto Tanaka,3 Makoto Naganuma,4 Shin Maeda,5 Reiko Kunisaki,1 Noriko Yamamoto-Mitani2 1Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Minami-ku, Yokohama, Japan; 2Department of Gerontological Home Care and Long-term Care Nursing, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; 3Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok, Thailand; 4Division of Gastroenterology and Hepatology, Keio University, Shinjuku-ku, Tokyo, Japan; 5Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan Background: Overall, 30%–45% of patients with ulcerative colitis (UC are non-adherent and have difficulties taking their medications; this non-adherence increases the risk of clinical relapse 1.4- to 5.5-fold. This study aimed to clarify the strategies patients employ to facilitate adherence and determine whether the strategies had an impact on good adherence.Methods: This was a cross-sectional survey using a self-administered questionnaire and review of medical records. Patients diagnosed as having UC and attending one of the outpatient clinics of four urban hospitals from June 2009 to December 2012 were enrolled. A questionnaire was developed to identify the strategies patients employ to facilitate adherence and then administered to patients with UC. Adherence to 5-aminosalicylic acid was calculated, and univariate and multiple logistic regression analyses were performed to determine the strategies that were associated with good adherence.Results: The final analyses included 671 participants (mean age 40.2 years; 54.3% males. The valid response rate was 96.9%; 186 (27.7% participants were classified as non-adherent, the mean adherence rate being 86.1% (standard deviation [SD] 17.9. Seven strategies that patients employ to facilitate adherence were identified, the

  11. A retrospective study of nine cases of Acanthamoeba keratitis

    Tetsuya Mutoh


    Full Text Available Tetsuya Mutoh, Isao Ishikawa, Yukihiro Matsumoto, Makoto ChikudaDokkyo Medical University Koshigaya Hospital, Saitama, JapanPurpose: To evaluate the clinical features of Acanthamoeba keratitis in nine patients diagnosed at Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.Methods: In nine eyes of nine patients, Acanthamoeba keratitis was diagnosed by direct light microscopy of corneal scrapings stained by the Parker ink-potassium hydroxide method between September 2006 and September 2009. Their clinical features and course were studied retrospectively. Antifungal eye drops, systemic antifungal therapy, and surgical debridement of the corneal lesions were performed in all patients.Results: At presentation, the clinical stage was initial in six cases, transient in one case, and complete in two cases. The patients were all contact lens wearers who had washed their lens storage cases with tap water. After treatment, final visual acuity was improved in six cases, unchanged in one case, and worse in two cases. The patient with the worst final vision (hand motion had rheumatoid arthritis and was taking oral prednisolone, which led to corneal perforation and prevented adequate debridement from being done.Conclusion: Acanthamoeba keratitis is closely related to wearing contact lenses and washing the lens storage case with tap water. Although final visual acuity improved after treatment in most patients, insufficient surgical debridement resulted in a poor visual prognosis.Keywords: surgical debridement, Acanthamoeba keratitis, contact lens wearers

  12. A case of cholestatic hepatitis associated with histologic features of acute cholangitis

    Takeuchi H


    Full Text Available Hajime Takeuchi1, Toru Kaneko1, Toshikazu Otsuka1, Kumiko Tahara1, Tadashi Motoori2, Makoto Ohbu3, Masaya Oda4, Hiroaki Yokomori11Department of Internal Medicine; 2Division of Pathology, Kitasato Medical Center Hospital, Kitasato University, Saitama; 3Department of Pathology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa; 4Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama; 5Organized Center of Clinical Medicine, International University of Health and Welfare, Sanno Hospital, Tokyo, JapanAbstract: This report describes a case showing histologic features of acute cholangitis with an over-the-counter drug. A 48-year-old woman was diagnosed with general malaise and progressive jaundice. A thorough review of her medical history revealed that the patient had taken an over-the-counter drug, Pabron Gold®, which she had used previously, that may have caused liver injury. Laboratory investigations revealed jaundice and liver dysfunction. Endoscopic retrograde cholangiography detected no extrahepatic biliary duct dilatation or stones. Liver biopsy indicated acute cholangitis involving neutrophils and eosinophils. Electron microscopy revealed fragmented nuclei, indicating that the degenerative bile duct-related epithelial cells were in an apoptotic process.Keywords: liver injury, over-the-counter drug, histologic features, acute cholangitis, electron microscopy, Pabron Gold

  13. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Mutoh T


    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  14. Selective laser trabeculoplasty for elevated intraocular pressure following subtenon injection of triamcinolone acetonide

    Kenya Yuki


    Full Text Available Kenya Yuki1, Makoto Inoue1,2, Daisuke Shiba1, Ryosuke Kawamura1, Susumu Ishida1, Yuichiro Ohtake11Department of Ophthalmology, Keio University School of Medicine, 2Kyorin Eye Center, Kyorin University School of Medicine, Mitaka, Tokyo, JapanPurpose: To report on the efficacy of selective laser trabeculoplasty (SLT for elevated intraocular pressure (IOP following subtenon injection of triamcinolone acetonide.Method: SLT was performed on four of 148 eyes in which IOP was elevated after a subtenon injection of triamcinolone acetonide and could not be maintained within normal limits by conventional medications. Postoperative IOP and relative reduction of IOP were evaluated.Results: IOP was reduced in three eyes to within the normal range without any medications six months after SLT alone, but trabeculotomy was performed on one eye. Percentage reduction in IOP after SLT was 21.6% at one month, 45.0% at three months, and 52.7% at nine months.Conclusion: SLT may be effective in reducing elevated IOP following subtenon injection of triamcinolone acetonide and should be considered before glaucoma surgery.Keywords: selective laser trabeculoplasty, steroid glaucoma, subtenon injection, triamcinolone acetonide

  15. Adherence ability of Staphylococcus epidermidis on prosthetic biomaterials: an in vitro study

    Shida T


    Full Text Available Takayuki Shida,1 Hironobu Koseki,1 Itaru Yoda,1 Hidehiko Horiuchi,1 Hideyuki Sakoda,2 Makoto Osaki11Department of Orthopedic Surgery, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan; 2Division of Medical Devices, National Institute of Health Sciences, Tokyo, JapanAbstract: Bacterial adhesion to the surface of biomaterials is an essential step in the pathogenesis of implant-related infections. In this in vitro research, we evaluated the ability of Staphylococcus epidermidis to adhere to the surface of solid biomaterials, including oxidized zirconium-niobium alloy (Oxinium, cobalt-chromium-molybdenum alloy, titanium alloy, commercially pure titanium, and stainless steel, and performed a biomaterial-to-biomaterial comparison. The test specimens were physically analyzed to quantitatively determine the viable adherent density of the S. epidermidis strain RP62A (American Type Culture Collection [ATCC] 35984. Field emission scanning electron microscope and laser microscope examination revealed a featureless, smooth surface in all specimens (average roughness <10 nm. The amounts of S. epidermidis that adhered to the biomaterial were significantly lower for Oxinium and the cobalt-chromium-molybdenum alloy than for commercially pure titanium. These results suggest that Oxinium and cobalt-chromium-molybdenum alloy are less susceptible to bacterial adherence and are less inclined to infection than other materials of a similar degree of smoothness.Keyword: bacterial adhesion, implant, infection, surface character

  16. Optimization of fuel cells for BWR based in Tabu modified search; Optimizacion de celdas de combustible para BWR basada en busqueda Tabu modificada

    Martin del Campo M, C.; Francois L, J.L. [Facultad de Ingenieria, UNAM, Laboratorio de Analisis en Ingenieria de Reactores Nucleares, Paseo Cuauhnahuac 8532, 62550 Jiutepec, Morelos (Mexico); Palomera P, M.A. [Facultad de Ingenieria, UNAM, Posgrado en Ingenieria en Computacion, Circuito exterior s/n, Ciudad Universitaria, Mexico, D.F. (Mexico)]. e-mail:


    The advances in the development of a computational system for the design and optimization of cells for assemble of fuel of Boiling Water Reactors (BWR) are presented. The method of optimization is based on the technique of Tabu Search (Tabu Search, TS) implemented in progressive stages designed to accelerate the search and to reduce the time used in the process of optimization. It was programed an algorithm to create the first solution. Also for to diversify the generation of random numbers, required by the technical TS, it was used the Makoto Matsumoto function obtaining excellent results. The objective function has been coded in such a way that can adapt to optimize different parameters like they can be the enrichment average or the peak factor of radial power. The neutronic evaluation of the cells is carried out in a fine way by means of the HELIOS simulator. In the work the main characteristics of the system are described and an application example is presented to the design of a cell of 10x10 bars of fuel with 10 different enrichment compositions and gadolinium content. (Author)

  17. Preferences for oral versus intravenous adjuvant chemotherapy among early breast cancer patients

    Ishitobi M


    Full Text Available Makoto Ishitobi,1 Kazuyo Shibuya,2 Yoshifumi Komoike,1 Hiroki Koyama,1 Hideo Inaji1 1Department of Breast and Endocrine Surgery, 2Department of Nursing, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan Purpose: The purpose of this study was to evaluate preferences for oral versus intravenous adjuvant chemotherapy among early breast cancer patients (UMIN-CTR number UMIN000004696. Patients and methods: Eighty-two postmenopausal women with estrogen receptor-positive, human epidermal growth-factor receptor 2-negative breast cancer who had completed adjuvant chemotherapy were asked about their preferred route of administration of chemotherapy and the reason. Women also answered questions about their physical and psychological status and quality of life during chemotherapy. Results: Patients who had received oral chemotherapy preferred it more frequently than those who had received intravenous chemotherapy (100% versus 37%, respectively, chi-square =15.5; P<0.001. Patients who preferred the same route of administration of chemotherapy as they had previously received showed a significantly better psychological status during chemotherapy compared with those who preferred a different route. Conclusion: Our study showed that preferences for oral and intravenous chemotherapy strongly depended on the actual prior administration of chemotherapy and patients' own experiences during chemotherapy. Keywords: breast cancer, adjuvant, chemotherapy, patient preference, oral, intravenous

  18. Report on survey in fiscal 2000 on the survey on succession of history of industrial technologies. Survey edition of originality and creativity of electric and electronic technologies in Japan; 2000 nendo sangyo gijutsu rekishi keisho chosa hokokusho. Kokunai sangyo no denki denshi gijutsu no dokusosei to sozosei no chosahen



    In order to clarify the innovation process of industrial technologies in Japan and the originality and creativity seen in that process to serve for the future development, hearing surveys have been performed. The persons being the hearing objects are Mr. Koichi Oshima who has researched the series capacitors for power transmission cables, Mr. Makoto Osatake who has researched the distortion in frequency modulation, and Mr. Hisao Oka who has researched the destruction phenomena in rectifier elements of power semiconductors. Mr. Hiroshi Inose and Mr. Toichiro Koike who have accepted the hearing survey were represented by the mourning statements due to their sudden death. The items of the questions in the hearing survey included: their home background, why have they studied electricity area specially?, determination criteria when they were forced to make a serious selection and the results thereof, examples of successes and failures and the age background, breakthrough points in the success cases, what they want to convey to future generations from their achievements, what they wished if they have done, methods of conveying the technologies, persons whom they respect as their teachers, existence of persons who have given them protection, sources of passion and motivation that supported the research life, and the principles toward the research. (NEDO)

  19. A case of iridoschisis associated with lens displacement into the vitreous cavity

    Tetsuya Mutoh


    Full Text Available Tetsuya Mutoh1, Yukihiro Matsumoto1, Makoto Chikuda11Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Saitama, JapanAbstract: We report the case of a 67-year-old woman with a lens that was displaced into the vitreous cavity in one eye and ipsilateral iridoschisis. She was free from a history of ocular trauma or of heritable ocular disease. Her best-corrected visual acuity was 1.2 bilaterally and right eye showed signs of iridoschisis. The corneal endothelial cell density decreased to 1,263 cells/mm2 in the right eye preoperatively. We speculated that iris tissue flowing in the anterior chamber might have intermittently touched the corneal endothelium. 25-gauge pars plana vitrectomy and lens removal were performed immediately. Free-floating iris tissue was cut during surgery with care not to injure the corneal endothelial cells. The postoperative progress was satisfactory and scleral fixation of an intraocular lens is planned. Iridoschisis is an uncommon cause of lens displacement into the vitreous cavity.Keywords: lens displacement, vitreous cavity, iridoschisis, corneal endothelial cell density, free-floating iris tissue

  20. BRAIN vol. 4 (2013, issues 1-4, first 4 pages

    Bogdan Patrut


    Full Text Available TABLE OF CONTENTS Sections BRAINStorming and BRAINovations 1. Evolving Spiking Neural Networks for Control of Artificial Creatures 5Arash Ahmadi 2. Artificial Neuron Modelling Based on Wave Shape 20Kieran Greer 3. Brain-Like Artificial Intelligence for Automation – Foundations, Concepts andImplementation Examples 26Rosemarie Velik 4. Performance Analysis of Unsupervised Clustering Methods for Brain Tumor Segmentation 55Tushar H Jaware and Dr. K B Khanchandani 5. High Performance Data mining by Genetic Neural Network 60Dadmehr Rahbari 6. Isomorphism Between Estes’ Stimulus Fluctuation Model and a Physical-Chemical System 71Makoto Yamaguchi 7. Intelligent Continuous Double Auction method For Service Allocation in Cloud Computing 74Nima Farajian, Kamran Zamanifar 8. An Enhancement Over Texture Feature Based Multiclass Image Classification UnderUnknown Noise 84Ajay Kumar Singh, V P Shukla, Shamik Tiwari and S R Biradar 9. Suicide: Neurochemical Approaches 97Ritabrata Banerjee, Anup K. Ghosh, Balaram Ghosh, Somnath Bhattacharya and Amal C. Mondal 10. L1 Transfer in Post-Verbal Preposition: An Inter-level Comparison 125Samira Mollaei, Ali Jahangard and Hemaseh Bagheri Section BRAINotes 11. Looking for Oriental fundamentals Fuzzy Logic 141Ángel Garrido and Piedad Yuste Instructions for authors 146

  1. Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice

    Umeda M


    Full Text Available Makoto Umeda,1 Masaki Hiramoto,1,2 Takeshi Imai1 1Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; 2Department of Biochemistry, Tokyo Medical University, Tokyo, Japan Abstract: Estrogens play central roles in sexual development, reproduction, and hepatocyte proliferation. The ovaries are one of the main organs for estradiol (E2 production. Ovariectomies (OVXs were performed on the female mice, and hepatocyte proliferation was analyzed. The ovariectomized mice exhibited delayed hepatocyte proliferation after partial hepatectomy (PH and also exhibited delayed and reduced E2 induction. Both E2 administration and PH induced the gene expression of estrogen receptor α (ERα. The transcripts of ERα were detected specifically in periportal hepatocytes after E2 administration and PH. Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle. Taken together, these findings indicate that E2 accelerated ERα expression in periportal hepatocytes and hepatocyte proliferation in the female mice.Keywords: estrogen, ER, estrous cycle, hepatocyte proliferation, liver regeneration

  2. Diffractive multifocal intraocular lens interferes with intraoperative view

    Mami Yoshino


    Full Text Available Mami Yoshino1, Makoto Inoue1,2, Nae Kitamura1, Hiroko Bissen-Miyajima11Department of Ophthalmology, Tokyo Dental College Suidobashi Hospital, Tokyo, Japan; 2Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, JapanAbstract: We report an unusual finding during vitreous surgery in an eye implanted with a diffractive multifocal intraocular lens (IOL. A 70-year-old woman reported gradual visual deterioration to 20/40 in the left eye two and a half years after uneventful cataract surgery with implantation of a diffractive multifocal IOL. Funduscopic examination showed an epiretinal membrane (ERM in the left eye. Increased macular traction was believed to cause the visual deterioration. Vitreous surgery with removal of the ERM was performed and triamcinolone acetonide (TA was injected intravitreally to visualize the residual vitreous cortex. Although the ERM was peeled successfully, the ability to focus on the vitreoretinal interface through the IOL required great effort with decreased contrast sensitivity and ghost images of the intravitreal TA crystals. The vision improved to 20/25 4 months postoperatively. Macular surgery can be performed in an eye with a diffractive multifocal IOL; however, decreased contrast sensitivity and ghost images may interfere with the intraoperative view through the diffractive IOL in complicated cases.Keywords: diffractive multifocal intraocular lens, intraoperative view

  3. Lévy matters V functionals of Lévy processes

    Andersen, Lars Nørvang; Aurzada, Frank; Glynn, Peter W; Maejima, Makoto; Pihlsgård, Mats; Simon, Thomas


    This three-chapter volume concerns the distributions of certain functionals of Lévy processes. The first chapter, by Makoto Maejima, surveys representations of the main sub-classes of infinitesimal distributions in terms of mappings of certain Lévy processes via stochastic integration. The second chapter, by Lars Nørvang Andersen, Søren Asmussen, Peter W. Glynn and Mats Pihlsgård, concerns Lévy processes reflected at two barriers, where reflection is formulated à la Skorokhod. These processes can be used to model systems with a finite capacity, which is crucial in many real life situations, a most important quantity being the overflow or the loss occurring at the upper barrier.  If a process is killed when crossing the boundary, a natural question concerns its lifetime. Deep formulas from fluctuation theory are the key to many classical results, which are reviewed in the third chapter by Frank Aurzada and Thomas Simon. The main part, however, discusses recent advances and developments in the setting w...

  4. Injuries and disorders among young ice skaters: relationship with generalized joint laxity and tightness

    Okamura S


    Full Text Available Shinobu Okamura,1 Naoki Wada,1 Masayuki Tazawa,1 Makoto Sohmiya,1 Yoko Ibe,1 Toru Shimizu,1 Shigeru Usuda,2 Kenji Shirakura1 1Department of Rehabilitation Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; 2Department of Physical Therapy, Gunma University School of Health Science, Maebashi, Gunma, Japan Abstract: This study retrospectively investigated 192 teenage speed and figure skaters with prior injuries documented by an athletes’ questionnaire, who underwent a physical examination to assess their muscle tightness and generalized joint laxity. In all athletes, the degree of muscle tightness and joint laxity were measured by a standardized physical examination. A descriptive report of the types of injuries showed a predominance of fractures, ligament injuries, enthesitis, and lower back pain. Approximately 5% of all skaters tested positive for tightness, while 25.8% of figure skaters and 15.2% of speed skaters had generalized ligamentous laxity. Statistical testing showed an association between ankle sprains and muscle tightness, and an association between knee enthesitis and muscle tightness in skating athletes. There was also an association between lower back pain and generalized joint laxity, which held true only for the male skaters. Keywords: sports injury, skating, junior athlete, tightness, joint laxity, medical checkup

  5. Nanometer-thin TiO2 enhances skeletal muscle cell phenotype and behavior

    Ishizaki K


    Full Text Available Ken Ishizaki*, Yoshihiko Sugita*, Fuminori Iwasa, Hajime Minamikawa, Takeshi Ueno, Masahiro Yamada, Takeo Suzuki, Takahiro OgawaLaboratory for Bone and Implant Sciences, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA*Authors contributed equally to this workBackground: The independent role of the surface chemistry of titanium in determining its biological properties is yet to be determined. Although titanium implants are often in contact with muscle tissue, the interaction of muscle cells with titanium is largely unknown. This study tested the hypotheses that the surface chemistry of clinically established microroughened titanium surfaces could be controllably varied by coating with a minimally thin layer of TiO2 (ideally pico-to-nanometer in thickness without altering the existing topographical and roughness features, and that the change in superficial chemistry of titanium is effective in improving the biological properties of titanium.Methods and results: Acid-etched microroughened titanium surfaces were coated with TiO2 using slow-rate sputter deposition of molten TiO2 nanoparticles. A TiO2 coating of 300 pm to 6.3 nm increased the surface oxygen on the titanium substrates in a controllable manner, but did not alter the existing microscale architecture and roughness of the substrates. Cells derived from rat skeletal muscles showed increased attachment, spread, adhesion strength, proliferation, gene expression, and collagen production at the initial and early stage of culture on 6.3 nm thick TiO2-coated microroughened titanium surfaces compared with uncoated titanium surfaces.Conclusion: Using an exemplary slow-rate sputter deposition technique of molten TiO2 nanoparticles, this study demonstrated that titanium substrates, even with microscale roughness, can be sufficiently chemically modified to

  6. A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text

    Miwa, Makoto; Ohta, Tomoko; Rak, Rafal; Rowley, Andrew; Kell, Douglas B.; Pyysalo, Sampo; Ananiadou, Sophia


    Motivation: To create, verify and maintain pathway models, curators must discover and assess knowledge distributed over the vast body of biological literature. Methods supporting these tasks must understand both the pathway model representations and the natural language in the literature. These methods should identify and order documents by relevance to any given pathway reaction. No existing system has addressed all aspects of this challenge. Method: We present novel methods for associating pathway model reactions with relevant publications. Our approach extracts the reactions directly from the models and then turns them into queries for three text mining-based MEDLINE literature search systems. These queries are executed, and the resulting documents are combined and ranked according to their relevance to the reactions of interest. We manually annotate document-reaction pairs with the relevance of the document to the reaction and use this annotation to study several ranking methods, using various heuristic and machine-learning approaches. Results: Our evaluation shows that the annotated document-reaction pairs can be used to create a rule-based document ranking system, and that machine learning can be used to rank documents by their relevance to pathway reactions. We find that a Support Vector Machine-based system outperforms several baselines and matches the performance of the rule-based system. The success of the query extraction and ranking methods are used to update our existing pathway search system, PathText. Availability: An online demonstration of PathText 2 and the annotated corpus are available for research purposes at Contact: Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23813008

  7. Viral vectors for cystic fibrosis gene therapy: What does the future hold?

    Uta Griesenbach


    Full Text Available Uta Griesenbach1, Makoto Inoue2, Mamoru Hasegawa2, Eric WFW Alton11Department of Gene Therapy, Imperial College London, UK; The UK Cystic Fibrosis Gene Therapy Consortium; 2DNAVEC Corporation, Tsukuba, JapanAbstract: Gene transfer to the airway epithelium has been more difficult than originally anticipated, largely because of significant extra- and intracellular barriers in the lung. In general, viral vectors are more adapted to overcoming these barriers than nonviral gene transfer agents and are, therefore, more efficient in transferring genes into recipient cells. Viral vectors derived from adenovirus, adeno-associated virus, and Sendai virus, which all have a natural tropism for the airway epithelium, have been evaluated for cystic fibrosis (CF gene therapy. Although these vectors transduce airway epithelial cells efficiently, gene expression is transient and repeated administration is inefficient. They are, therefore, unlikely to be suitable for CF gene therapy. More recently, lentiviruses (LV have been assessed for lung gene transfer. In contrast to retroviruses, they transduce nondividing cells and randomly integrate into the genome. However, LVs do not have a natural tropism for the lung, and a significant amount of effort has been put into pseudotyping these vectors with proteins suitable for airway gene transfer. Several studies have shown that LV-mediated transduction leads to persistent gene expression (for the lifetime of the animal in the airways and, importantly, repeated administration is feasible. Thus, appropriately pseudotyped LV vectors are promising candidates for CF gene therapy. Here, we will review preclinical and clinical research related to viral CF gene therapy.Keywords: cystic fibrosis, gene therapy, adenovirus, AAV, lentivirus, Sendai virus

  8. Assertions of Japanese Websites for and Against Cancer Screening: a Text Mining Analysis

    Okuhara, Tsuyoshi; Ishikawa, Hirono; Okada, Masahumi; Kato, Mio; Kiuchi, Takahiro


    Background: Cancer screening rates are lower in Japan than in Western countries such as the United States and the United Kingdom. While health professionals publish pro-cancer-screening messages online to encourage proactive seeking for screening, anti-screening activists use the same medium to warn readers against following guidelines. Contents of pro- and anti-cancer-screening sites may contribute to readers’ acceptance of one or the other position. We aimed to use a text-mining method to examine frequently appearing contents on sites for and against cancer screening. Methods: We conducted online searches in December 2016 using two major search engines in Japan (Google Japan and Yahoo! Japan). Targeted websites were classified as “pro”, “anti”, or “neutral” depending on their claims, with the author(s) classified as “health professional”, “mass media”, or “layperson”. Text-mining analyses were conducted, and statistical analysis was performed using the chi-square test. Results: Of the 169 websites analyzed, the top-three most frequently appearing content topics in pro sites were reducing mortality via cancer screening, benefits of early detection, and recommendations for obtaining detailed examination. The top three most frequent in anti-sites were harm from radiation exposure, non-efficacy of cancer screening, and lack of necessity of early detection. Anti-sites also frequently referred to a well-known Japanese radiologist, Makoto Kondo, who rejects the standard forms of cancer care. Conclusion: Our findings should enable authors of pro-cancer-screening sites to write to counter misleading anti-cancer-screening messages and facilitate dissemination of accurate information. Creative Commons Attribution License

  9. Evaluation of actual retinal images produced by misaligned aspheric intraocular lenses in a model eye

    Fujikado T


    Full Text Available Takashi Fujikado,1 Makoto Saika2 1Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Research and Development Department of Topcon Corporation, Tokyo, Japan Purpose: To examine the effect of misalignment (decentration and tilt of intraocular lenses (IOLs on retinal image quality using a water-immersed model eye with corneal spherical aberration adjusted to the values found in normal human eyes (spherical aberration 0.25 µm; pupil diameter 6 mm.Methods: Three types of IOL holders were prepared. The first was without decentration or tilt, the second had a decentration of 0.5 mm, and the third had a tilt of 5.0°. One spherical IOL and three aspherical IOLs, each with a power of +20 D, were set in the holders and their optical properties (wave front aberration, defocused modulation transfer function, defocused point spread function, and Landolt ring simulations were compared.Results: Coma aberrations generated by misaligned IOLs were related to the spherical aberration corrective power of the IOLs. Landolt ring simulations show that the depth of focus increased as spherical aberration increased and that the retinal image quality was degraded by increases in coma aberration.Conclusion: Coma aberration was generated by IOLs with a large degree of spherical aberration correction, leading to reduced retinal image quality when the IOL was misaligned. This suggests that, in a clinical setting, the quality of vision might be improved by reducing the degree of coma aberration using IOLs that retain, or minimally correct, spherical aberration. Keywords: coma aberration, decentration, misalignment, spherical aberration, tilt

  10. Population pharmacokinetics of olprinone in healthy male volunteers

    Kunisawa T


    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  11. Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

    Nami Nishikiori


    Full Text Available Nami Nishikiori1,2, Makoto Osanai2, Hideki Chiba2, Takashi Kojima2, Shuichiro Inatomi1,2, Hiroshi Ohguro1, Norimasa Sawada2Departments of 1Ophthalmology and 2Pathology, Sapporo Medical University School of MedicinePurpose: This study was conducted to investigate whether retinoic acids (RAs had any effect on apoptosis during the development of diabetic retinopathy.Methods: To investigate whether RAs had any effect on apoptosis during the development of diabetic retinopathy, we housed 32 C57BL/6 male mice and induced diabetes in 24 by intra peritoneal injections of streptozotocin (STZ; Sigma, St Louis, MO and treated 16 of the diabetic mice with the RAs, all-trans-retinoic acid (ATRA (seven mice and 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarboxamido] benzoic acid (Am580 (nine mice. The other eight mice were used as diabetic controls. We then measured apoptosis in the retina by TdT-dUTP terminal nick-end labeling assay.Results: RAs inhibited the apoptosis of retinal cells in diabetic retinopathy. Many apoptotic cells were observed in retinas of the eight diabetic control mice (mean value and SD: 37.8 ± 6.9, whereas when diabetic mice were treated with RAs, the number of apoptotic cells significantly decreased (mean value and SD: 9.9 ± 6.4 for the seven ATRA-treated diabetic mice and 9.8 ± 5.9 for the nine Am580-treated diabetic mice (p < 0.05.Conclusion: Treatment with RAs decreases apoptosis during the development of diabetic retinopathy.Keywords: retinoic acids, apoptosis, diabetic retinopathy, glial cell line-derived neurotrophic factor

  12. A case of radial keratoneuritis in non-Acanthamoeba keratitis

    Mutoh T


    Full Text Available Tetsuya Mutoh, Yukihiro Matsumoto, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Saitama, JapanAbstract: A case of non-Acanthamoeba keratitis with radial keratoneuritis, which is thought to be pathognomonic for Acanthamoeba keratitis, is reported. A healthy 32-year-old woman with a history of frequent replacement of her contact lenses due to wear was examined at Dokkyo Medical University Koshigaya Hospital (Saitama, Japan and found to have a slight corneal opacity that was accompanied by radial keratoneuritis. Based on both the patient’s clinical findings and past history, the presence of Acanthamoeba keratitis was highly suspected. However, direct light microscopy of corneal scrapings stained by the Parker ink–potassium hydroxide method only found Acanthamoeba-type material in the specimen collected at her initial visit. In all other specimens collected from the patient, no Acanthamoeba was found either when using the same method or when performing cultures of the surgical debridement of the corneal lesion. In addition, topical antifungal eye drops, systemic antifungal drugs, and surgical debridement were also not effective in this case. Since a precise diagnosis could not be made, the patient was treated with topical 0.1% betamethasone sodium, which ultimately resulted in a dramatic improvement of her corneal inflammation. At 23 days after initiation of topical administration of 0.1% betamethasone sodium, visual acuity was 20/250, with a slight corneal opacity noted at the original site of infection. The outcome of the current case suggests that radial keratoneuritis is not always pathognomonic for Acanthamoeba keratitis.Keywords: radial keratoneuritis, non-Acanthamoeba keratitis, topical corticosteroid


    SAMIOS, N.P.


    The eighth evaluation of the RIKEN BNL Research Center (RBRC) took place on October 10-12, 2005, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Jean-Paul Blaizot, Professor Makoto Kobayashi, Dr. Akira Masaike, Professor Charles Young Prescott (Chair), Professor Stephen Sharpe (absent), and Professor Jack Sandweiss. We are grateful to Professor Akira Ukawa who was appointed to the SRC to cover Professor Sharpe's area of expertise. In addition to reviewing this year's program, the committee, augmented by Professor Kozi Nakai, evaluated the RBRC proposal for a five-year extension of the RIKEN BNL Collaboration MOU beyond 2007. Dr. Koji Kaya, Director of the Discovery Research Institute, RIKEN, Japan, presided over the session on the extension proposal. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on higher research efforts. In addition, a special session was held in connection with the RBRC QCDSP and QCDOC supercomputers. Professor Norman H. Christ, a collaborator from Columbia University, gave a presentation on the progress and status of the project, and Professor Frithjof Karsch of BNL presented the first physics results from QCDOC. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.

  14. Submucosal tunneling techniques: current perspectives

    Kobara H


    Full Text Available Hideki Kobara,1 Hirohito Mori,1 Kazi Rafiq,2 Shintaro Fujihara,1 Noriko Nishiyama,1 Maki Ayaki,1 Tatsuo Yachida,1 Tae Matsunaga,1 Johji Tani,1 Hisaaki Miyoshi,1 Hirohito Yoneyama,1 Asahiro Morishita,1 Makoto Oryu,1 Hisakazu Iwama,3 Tsutomu Masaki1 1Department of Gastroenterology and Neurology, 2Department of Pharmacology, 3Life Science Research Center, Faculty of Medicine, Kagawa University, Miki-cho, Kita-Gun, Kagawa, Japan Abstract: Advances in endoscopic submucosal dissection include a submucosal tunneling technique, involving the introduction of tunnels into the submucosa. These tunnels permit safer offset entry into the peritoneal cavity for natural orifice transluminal endoscopic surgery. Technical advantages include the visual identification of the layers of the gut, blood vessels, and subepithelial tumors. The creation of a mucosal flap that minimizes air and fluid leakage into the extraluminal cavity can enhance the safety and efficacy of surgery. This submucosal tunneling technique was adapted for esophageal myotomy, culminating in its application to patients with achalasia. This method, known as per oral endoscopic myotomy, has opened up the new discipline of submucosal endoscopic surgery. Other clinical applications of the submucosal tunneling technique include its use in the removal of gastrointestinal subepithelial tumors and endomicroscopy for the diagnosis of functional and motility disorders. This review suggests that the submucosal tunneling technique, involving a mucosal safety flap, can have potential values for future endoscopic developments. Keywords: submucosal endoscopy, submucosal tunneling method, natural orifice transluminal endoscopic surgery, peroral endoscopic myotomy, gastrointestinal subepithelial tumor, functional and motility disorders

  15. Photorefractive keratectomy: measuring the matrix metalloproteinase activity and chondroitin sulfate concentration in tear fluid

    Tetsuya Mutoh


    Full Text Available Tetsuya Mutoh, Masaya Nishio, Yukihiro Matsumoto, Kiyomi Arai, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Saitama, JapanAbstract: We herein report the case of a 20-year-old man who underwent a photorefractive keratectomy (PRK. We measured matrix metalloproteinase-9 (MMP-9 activity and chondroitin 4 sulfate and chondroitin 6 sulfate concentrations in tear fluid. Tear fluid was collected preoperatively via microcapillary tube, and was collected postoperatively on the first and fourth days, and after one week, one month, three months, and six months. Samples were formulated by dilution with 200 µL of saline. MMP-9 activity was analyzed by an enzyme immunocapture activity assay, and the concentrations of chondroitin sulfate were analyzed by enzyme-linked immunosorbent assay. No complications were observed after surgery, except for a minimal subepithelial haze. Although MMP-9 activity changed on the fourth postoperative day, the activity changed only minimally at this time. Chondroitin 4 sulfate concentrations in tear fluid increased dramatically from one week to one month, decreased transiently at three months, and increased by six months. The chondroitin 6 sulfate concentration did not normalize within one week, and decreased from one week to three months compared with the preoperative score, and was close to the preoperative score at six months. We conclude that corneal wound healing was still incomplete six months after PRK, and chondroitin 4 sulfate appears to be critical in this process.Keywords: matrix metalloproteinase, chondroitin sulfate, human tear fluid, photorefractive keratectomy, corneal wound healing

  16. Use of pars plana vitrectomy with phacoemulsification in vitreous cavity to treat complete posterior dislocation of lens

    Mutoh T


    Full Text Available Tetsuya Mutoh, Yukihiro Matsumoto, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanBackground: The purpose of this study was to evaluate pars plana vitrectomy (PPV with phacoemulsification in the vitreous cavity for treatment of complete posterior dislocation of the lens without any damage to the lens capsule.Methods: We evaluated factors such as cause of dislocation, scleral fixation of an intraocular lens (IOL, preoperative and postoperative visual acuity, corneal endothelial cell density, and intraoperative and postoperative complications.Results: Displacement in the eleven eyes studied was mostly caused by ocular trauma and was idiopathic (four eyes each. Scleral fixation of the IOL was performed in seven of the eyes during first-time PPV. Visual acuity was improved in two eyes, unchanged in eight eyes, and worse in one eye. Mean corneal endothelial cell density was 2485 cells/mm2 preoperatively and 2301 cells/mm2 postoperatively. No significant differences were seen before and after the surgeries (P = 0.15, paired t-test. Intraoperative complications included retinal detachment and suprachoroidal hemorrhage in one eye each. The most common postoperative complication was transient ocular hypertension, which occurred in three eyes. IOL dislocation and vitreous incarceration of the anterior chamber in one eye required a second operation, while retinal detachment in one eye required a third operation.Conclusion: When treating a completely dislocated lens, prevention of retinal detachment which subsequently can affect the visual prognosis is the most important factor to be addressed after PPV with intravitreal phacoemulsification.Keywords: lens dislocation, pars plana vitrectomy, phacoemulsification in the vitreous cavity, retinal detachment

  17. Association of an overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis with cytomegalovirus infection

    Toyoda-Akui M


    Full Text Available Megumi Toyoda-Akui1,4, Hiroaki Yokomori1, Fumihiko Kaneko1,4, Yuki Shimizu1, Hajime Takeuchi1, Kumiko Tahara1, Hide Yoshida1, Hirobumi Kondo1, Tadashi Motoori2, Makoto Ohbu3, Masaya Oda5, Toshifumi Hibi61Department of Internal Medicine, 2Division of Pathology, Kitasato Medical Center Hospital, Kitasato University, Saitama; 3Department of Pathology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa; 4Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama; 5Organized Center of Clinical Medicine, International University of Health and Welfare, Tokyo; 6Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, JapanAbstract: A 63-year-old woman, who presented with severe jaundice and elevated serum conjugated bilirubin level, denied alcohol and drug use and showed no evidence of viral hepatitis. Based on clinical and laboratory features, she was diagnosed with autoimmune hepatitis with primary biliary cirrhosis. Hematological and immunochemical assays, radiographic imaging, clinical examination, and liver biopsy were conducted. Laboratory results were the following: negative for fluorescence antinuclear antibody, negative for antismooth muscle antibodies but positive for antinuclear antibody (enzyme-linked immunosorbent assay and antimitochondrial M2 antibody, high titers of serum globulin, and positive for cytomegalovirus IgM. Liver biopsy showed submassive lobular necrosis, inflammation with broad areas of parenchymal collapse, and chronic nonsuppurative destructive cholangitis. The patient responded well to corticosteroid therapy. This case might illustrate an association between cytomegalovirus infection and the occurrence of autoimmune hepatitis.Keywords: autoimmune hepatitis, fluorescence antinuclear antibody, enzyme linked immuno sorbent assay, primary biliary cirrhosis, cytomegalovirus infection

  18. Gene expression-based biological test for major depressive disorder: an advanced study

    Watanabe S


    Full Text Available Shin-ya Watanabe,1 Shusuke Numata,1 Jun-ichi Iga,2 Makoto Kinoshita,1 Hidehiro Umehara,1 Kazuo Ishii,3 Tetsuro Ohmori1 1Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 2Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Ehime, 3Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan Purpose: Recently, we could distinguished patients with major depressive disorder (MDD from nonpsychiatric controls with high accuracy using a panel of five gene expression markers (ARHGAP24, HDAC5, PDGFC, PRNP, and SLC6A4 in leukocyte. In the present study, we examined whether this biological test is able to discriminate patients with MDD from those without MDD, including those with schizophrenia and bipolar disorder.Patients and methods: We measured messenger ribonucleic acid expression levels of the aforementioned five genes in peripheral leukocytes in 17 patients with schizophrenia and 36 patients with bipolar disorder using quantitative real-time polymerase chain reaction (PCR, and we combined these expression data with our previous expression data of 25 patients with MDD and 25 controls. Subsequently, a linear discriminant function was developed for use in discriminating between patients with MDD and without MDD.Results: This expression panel was able to segregate patients with MDD from those without MDD with a sensitivity and specificity of 64% and 67.9%, respectively.Conclusion: Further research to identify MDD-specific markers is needed to improve the performance of this biological test. Keywords: depressive disorder, biomarker, gene expression, schizophrenia, bipolar disorder

  19. Warty gastric cancer with polypoid metastases to the gallbladder and urinary bladder

    Matsuyama M


    Full Text Available Mutsushi Matsuyama,1,2 Kazuo Kato,3 Seiichi Goto,4 Suzuko Moritani,5 Kazuhiro Sentani,6 Makoto Kuroda7 1Clinical Laboratory, Hekinan Municipal Hospital, Hekinan, Aichi, 2Department of Cell Biology and Anatomy, Fujita Health University School of Medicine, Toyoake, Aichi, 3Clinical Laboratory, Rousai Hospital, Nagoya, Aichi, 4Department of Internal Medicine, Hekinan Municipal Hospital, Hekinan, Aichi, 5Department of Advanced Diagnosis, Division of Pathology, National Hospital Organization, Nagoya Medical Center, Nagoya, Aichi, 6Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 7Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan Abstract: An 80-year-old man had severe lumbago that was diagnosed as multiple myeloma. He was treated with melphalan, prednisone, and zoledronic acid, with a good response. However, he had severe anemia, and endoscopic examination revealed gastric cancer. He died 3 months later. Autopsy revealed verrucous gastric cancer consisting of numerous polypoid mucosal excrescences that had metastasized to the gallbladder and urinary bladder, showing similar polypoid mucosal lesions. The cancer consisted of poorly differentiated cells (about 85% and signet ring cells (15% in the stomach. The cancerous tissue was not associated with a desmoplastic reaction, and the signet ring cells showed a positive reaction to cytokeratin 7 and regenerating islet-derived family member 4 antibodies. The cancer cells had a propensity to proliferate on the mucosal surface of the stomach, gallbladder, and urinary bladder. Keywords: warty gastric cancer, polypoid metastases, signet ring cells, cytokeratin 7, regenerating islet-derived family member 4

  20. Comparison of transtibial and transportal techniques in drilling femoral tunnels during anterior cruciate ligament reconstruction using 3D-CAD models

    Tashiro Y


    Full Text Available Yasutaka Tashiro,1 Ken Okazaki,1 Munenori Uemura,2 Kazutaka Toyoda,2 Kanji Osaki,1 Hirokazu Matsubara,1 Makoto Hashizume,2 Yukihide Iwamoto1 1Department of Orthopaedic Surgery, 2Department of Advanced Medical Initiatives, Kyushu University Hospital, Fukuoka, Japan Purpose: The purpose of this study was to assess the differences in bone tunnel apertures between the trans-accessory medial portal (trans-AMP technique and the transtibial (TT technique in double-bundle anterior cruciate ligament reconstruction. The extent of ovalization and the frequency of overlap of the two tunnel apertures were compared. Methods: The simulation of femoral tunnel drilling with the TT and the trans-AMP techniques was performed using three-dimensional computer aided design models from two volunteers. The incidence angle of drilling against the intercondylar wall, the femoral tunnel position, the ovalization, and the overlap were analyzed. The aperture and location of the tunnels were also examined in real anterior cruciate ligament reconstruction cases (n=36. Results: The surgical simulation showed that a lower drill incident angle induced by the TT technique made the apertures of two tunnels more ovalized, located anteromedial tunnels in a shallower position to prevent posterior wall blow out, and led to a higher frequency of tunnel overlap. The trans-AMP group had tunnel places within the footprint and had less ovalization and overlap. The results of analysis for tunnels in the clinical cases were consistent with results from the surgical simulation. Conclusion: In the TT technique, the shallow anteromedial tunnel location and more ovalized tunnel aperture can lead to a higher frequency of tunnel overlap. Compared with the TT technique, the trans-AMP technique was more useful in preparing femoral tunnels anatomically and avoiding tunnel ovalization and overlapping in double-bundle anterior cruciate ligament reconstruction. Keywords: anterior cruciate ligament

  1. Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial

    Takami T


    Full Text Available Takeshi Takami,1 Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, JapanPurpose: To compare the long-term effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP, left ventricular (LV mass index (LVMI, LV diastolic function (e´ velocity, E/e´ ratio, E/A ratio and arterial stiffness (brachial-ankle pulse wave velocity [baPWV] and augmentation index normalized for a heart rate of 75 bpm [AIx].Patients and methods: Patients with systolic BP ≥140 mmHg and/or diastolic BP ≥ 90 mmHg received olmesartan monotherapy (20 mg/day for 12 weeks. They were then randomly assigned to fixed-dose add-on therapy with azelnidipine (16 mg/day; n = 26 or amlodipine (5 mg/day; n = 26 for a further 2 years. CBP, LVMI, e´ velocity, E/e´ratio, E/A ratio, baPWV, and AIx were measured at baseline, 6 months, and 2 years.Results: Baseline characteristics of both groups were similar. The decrease in brachial BP over 2 years was similar in both groups. CBP, LVMI, E/e´ ratio, baPWV, and AIx decreased significantly, and the E/A ratio and e´ velocity increased significantly in both groups. The decreases in CBP (P < 0.001, AIx (P < 0.001, baPWV (P < 0.001, LVMI (P < 0.001, and E/e´ (P = 0.002 as well as the increase in E/A ratio (P = 0.03 over 2 years were significantly greater in the olmesartan/azelnidipine group than in the olmesartan/amlodipine group. Multivariate linear regression analyses showed that the changes in baPWV (β = 0.41, P < 0.001 and CBP (β = 0.47, P = 0.01 were independently associated with the change in LVMI, the change in baPWV (β = 0.25, P < 0.001 was independently associated with the change in E/e´ ratio, and the changes in baPWV (β = 0.21, P = 0.001 and AIx (β = 0.25, P = 0.03 were independently associated with the change in E/A ratio.Conclusion: Treatment with olmesartan/azelnidipine for

  2. TiO2 micro-nano-hybrid surface to alleviate biological aging of UV-photofunctionalized titanium

    Iwasa F


    Full Text Available Fuminori Iwasa1, Naoki Tsukimura1, Yoshihiko Sugita1, Rajita Kodali Kanuru1, Katsutoshi Kubo1, Hafiz Hasnain1, Wael Att1,2, Takahiro Ogawa11Laboratory of Bone and Implant Sciences (LBIS, The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA; 2Department of Prosthodontics, Dental School, Albert-Ludwigs University, Freiburg, GermanyAbstract: Bioactivity and osteoconductivity of titanium degrade over time after surface processing. This time-dependent degradation is substantial and defined as the biological aging of titanium. UV treatment has shown to reactivate the aged surfaces, a process known as photofunctionalization. This study determined whether there is a difference in the behavior of biological aging for titanium with micro-nano-hybrid topography and titanium with microtopography alone, following functionalization. Titanium disks were acid etched to create micropits on the surface. Micro-nano-hybrid surfaces were created by depositioning 300-nm diameter TiO2 nodules onto the micropits using a previously established self-assembly protocol. These disks were stored for 8 weeks in the dark to allow sufficient aging, then treated with UV light for 48 hours. Rat bone marrow–derived osteoblasts were cultured on fresh disks (immediately after UV treatment, 3-day-old disks (disks stored for 3 days after UV treatment, and 7-day-old disks. The rates of cell attachment, spread, proliferation, and levels of alkaline phosphatase activity, and calcium deposition were reduced by 30%–50% on micropit surfaces, depending on the age of the titanium. In contrast, 7-day-old hybrid surfaces maintained equivalent levels of bioactivity compared with the fresh surfaces. Both micropit and micro-nano-hybrid surfaces were superhydrophilic immediately after UV treatment. However, after 7 days, the micro-nano-hybrid surfaces became hydrorepellent

  3. On Japan’s Strategic Utilization of the U.S. Asia-Pacific Re-balancing%论日本对美国“亚太再平衡”的战略利用

    张瑞婷; 吴怀中


    Since the United States adopts the new Asia-Pacific Re-balancing Strategy, the White House considers Japan as an important tool to implement its goal. As for the response of Japan, the Japanese administration have made a series of adjustments which include the frustration of“de-link to the U.S.”policy of the Yukio Hatoyama Cabinet;the accepting attitude of the Naoto Cabinet and the Yoshihiko Noda Cabinet who started to follow the demand of the U.S. and tried to make a difference under the circumstance of the U.S.-Japan alliance. After Abe Shinzo came to power for the second time in 2012, Japan revealed its intention to take advantage of the U.S. Re-balancing Strategy as an important tool to achieve Japan’s political and military ambitions and to create its own strategic space, making a series of breakthroughs in the field of military security. The consecutive strategic adjustments of Japan accelerates its pace towards a total military rise, and has come more closer to its goal than any other time after World War II, having a negative impact on the security environment of China and the region.%美国实施“亚太再平衡”战略以来,不断加大对日本的利用力度。日本对此的反应,则经历了从民主党执政时期鸠山由纪夫内阁的“脱美”挫折、到菅直人内阁的顺应和政策回调、再到野田佳彦内阁开始跟进美国需求并试图在同盟框架下有所作为的调适过程。2012年底安倍晋三第二次上台执政后,日本进一步主动谋划、积极“用美”的意图彰显,将美国再平衡的对日需求作为实现军事崛起的战略工具加以运用,借美国重返之机推动了一系列军事安全领域的突破举措。日方如此连续的调适与利用,使其“国防正常化”和“军事大国化”取得了二战后最大的进展,也对中国及地区的安全环境产生着很大的影响。

  4. An open-label study of algorithm-based treatment versus treatment-as-usual for patients with schizophrenia

    Hirano J


    Full Text Available Jinichi Hirano,1,2 Koichiro Watanabe,3 Takefumi Suzuki,1,4 Hiroyuki Uchida,1 Ryosuke Den,5 Taishiro Kishimoto,1 Takashi Nagasawa,5 Yusuke Tomita,4 Koichiro Hara,6 Hiromi Ochi,7 Yoshimi Kobayashi,1 Mutsuko Ishii,1 Akane Fujita,1 Yoshihiko Kanai,1 Megumi Goto,1 Hiromi Hayashi,1 Kanako Inamura,1 Fumiko Ooshima,1 Mariko Sumida,1 Tomoko Ozawa,1 Kayoko Sekigawa,1 Maki Nagaoka,1 Kae Yoshimura,1 Mika Konishi,1 Ataru Inagaki,1 Takuya Saito,8 Nobutaka Motohashi,9 Masaru Mimura,1 Yoshiro Okubo,8 Motoichiro Kato,11Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 2Ohizumi Hospital, Tokyo, Japan; 3Department of Psychiatry School of Medicine, Kyorin University, Tokyo, Japan; 4Inokashira Hospital, Tokyo, Japan; 5Komagino Hospital, Tokyo, Japan; 6Asai Hospital, Chiba, Japan; 7Kurumegaoka Hospital, Tokyo, Japan; 8Department of Psychiatry School of Medicine, Nippon Medical School, Tokyo, Japan; 9Department of Psychiatry, School of Medicine, University of Yamanashi, Yamanashi, JapanObjective: The use of an algorithm may facilitate measurement-based treatment and result in more rational therapy. We conducted a 1-year, open-label study to compare various outcomes of algorithm-based treatment (ALGO for schizophrenia versus treatment-as-usual (TAU, for which evidence has been very scarce.Methods: In ALGO, patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, fourth edition were treated with an algorithm consisting of a series of antipsychotic monotherapies that was guided by the total scores in the positive and negative syndrome scale (PANSS. When posttreatment PANSS total scores were above 70% of those at baseline in the first and second stages, or above 80% in the 3rd stage, patients proceeded to the next treatment stage with different antipsychotics. In contrast, TAU represented the best clinical judgment by treating psychiatrists.Results: Forty-two patients (21 females, 39.0 ± 10.9 years

  5. Refractory cachexia is associated with increased plasma concentrations of fentanyl in cancer patients

    Suno M


    Full Text Available Manabu Suno,1,* Yuriko Endo,1,* Hiroyuki Nishie,2 Makoto Kajizono,3 Toshiaki Sendo,3 Junji Matsuoka4 1Department of Oncology Pharmaceutical Care and Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 3Department of Pharmacy, Okayama University Hospital, 4Faculty of Health Sciences, Okayama University Medical School, Okayama, Japan *These authors contributed equally to this work Background: An appropriate plasma concentration of fentanyl is the key to achieving good pain control in cancer patients. Cachexia, a multifactorial syndrome, is known to affect drug-metabolizing enzymes. However, the fentanyl concentrations in the blood of patients with cachexia have not been analyzed. The aim of this study was to evaluate the influence of cancer cachexia on dose-adjusted plasma fentanyl concentrations in cancer patients.Methods: Blood was collected from 21 Japanese cancer patients treated with a 24-hour transdermal fentanyl patch during the steady state of fentanyl plasma concentration. Plasma fentanyl concentrations were analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS, and the levels were adjusted with the dose of fentanyl. Laboratory data were collected, and the cachexia stage was determined, based on study by Fearon et al. Multiple regression analysis was performed to identify the factors that affected fentanyl plasma concentrations.Results: Eight patients were classified as precachexia, nine as cachexia, and four as refractory cachexia, and the median dose-adjusted fentanyl concentrations (ng/mL per mg/kg/day were 27.5, 34.4, and 44.5, respectively. The dose-adjusted fentanyl concentration in patients with refractory cachexia was higher than that in patients with precachexia (Kruskal–Wallis test and post hoc Mann–Whitney U-test, P<0.01. The factors that

  6. Objective assessment of skin tightening in Asians using a water-filtered near-infrared (1,000–1,800 nm device with contact-cooling and freezer-stored gel

    Tanaka Y


    Full Text Available Yohei Tanaka,1–3 Yuichiro Tsunemi,2 Makoto Kawashima,2 Naoto Tatewaki,3 Hiroshi Nishida31Clinica Tanaka Plastic, Reconstructive Surgery and Anti-aging Center, Nagano, 2Department of Dermatology, Tokyo Women's Medical University, Tokyo, 3Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, JapanBackground: Near-infrared has been shown to penetrate deeper than optical light sources independent of skin color, allowing safer treatment for the Asian skin type. Many studies have indicated the efficacy of various types of devices, but have not included a sufficiently objective evaluation. In this study, we used three-dimensional imaging for objective evaluation of facial skin tightening using a water-filtered near-infrared device.Methods: Twenty Japanese patients were treated with the water-filtered near-infrared (1,000–1,800 nm device using a contact-cooling and nonfreezing gel stored in a freezer. Three-dimensional imaging was performed, and quantitative volume measurements were taken to evaluate the change in post-treatment volume. The patients then provided their subjective assessments.Results: Objective assessments of the treated cheek volume evaluated by a three-dimensional color schematic representation with quantitative volume measurements showed significant improvement 3 months after treatment. The mean volume reduction at the last post-treatment visit was 2.554 ± 0.999 mL. The post-treatment volume was significantly reduced compared with the pretreatment volume in all patients (P < 0.0001. Eighty-five percent of patients reported satisfaction with the improvement of skin laxity, and 80% of patients reported satisfaction with improvement of rhytids, such as the nasolabial folds. Side effects, such as epidermal burns and scar formation, were not observed throughout the study.Conclusion: The advantages of this water-filtered near-infrared treatment are its high efficacy for skin tightening

  7. Accretion Discs Show Their True Colours


    Quasars are the brilliant cores of remote galaxies, at the hearts of which lie supermassive black holes that can generate enough power to outshine the Sun a trillion times. These mighty power sources are fuelled by interstellar gas, thought to be sucked into the hole from a surrounding 'accretion disc'. A paper in this week's issue of the journal Nature, partly based on observations collected with ESO's Very Large Telescope, verifies a long-standing prediction about the intensely luminous radiation emitted by these accretion discs. Uncovering the disc ESO PR Photo 21/08 Uncovering the inner disc "Astronomers were puzzled by the fact that the best models of these discs couldn't quite be reconciled with some of the observations, in particular, with the fact that these discs did not appear as blue as they should be," explains lead-author Makoto Kishimoto. Such a discrepancy could be the signal that there was something very wrong with the models. With his colleagues, he investigated this discrepancy by studying the polarised light from six quasars. This enabled them to demonstrate that the disc spectrum is as blue as predicted. "The crucial observational difficulty here has been that the disc is surrounded by a much larger torus containing hot dust, whose light partly outshines that of the disc," says Kishimoto. "Because the light coming from the disc is scattered in the disc vicinity and thus polarised, by observing only polarised light from the quasars, one can uncover the buried light from the disc." In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disc in infrared light. The observations were done with the FORS and ISAAC instruments on one of the 8.2-m Unit Telescopes of ESO's Very Large Telescope, located in the Atacama

  8. An angle encoder for super-high resolution and super-high accuracy using SelfA

    Watanabe, Tsukasa; Kon, Masahito; Nabeshima, Nobuo; Taniguchi, Kayoko


    Angular measurement technology at high resolution for applications such as in hard disk drive manufacturing machines, precision measurement equipment and aspherical process machines requires a rotary encoder with high accuracy, high resolution and high response speed. However, a rotary encoder has angular deviation factors during operation due to scale error or installation error. It has been assumed to be impossible to achieve accuracy below 0.1″ in angular measurement or control after the installation onto the rotating axis. Self-calibration (Lu and Trumper 2007 CIRP Ann. 56 499; Kim et al 2011 Proc. MacroScale; Probst 2008 Meas. Sci. Technol. 19 015101; Probst et al Meas. Sci. Technol. 9 1059; Tadashi and Makoto 1993 J. Robot. Mechatronics 5 448; Ralf et al 2006 Meas. Sci. Technol. 17 2811) and cross-calibration (Probst et al 1998 Meas. Sci. Technol. 9 1059; Just et al 2009 Precis. Eng. 33 530; Burnashev 2013 Quantum Electron. 43 130) technologies for a rotary encoder have been actively discussed on the basis of the principle of circular closure. This discussion prompted the development of rotary tables which achieve reliable and high accuracy angular verification. We apply these technologies for the development of a rotary encoder not only to meet the requirement of super-high accuracy but also to meet that of super-high resolution. This paper presents the development of an encoder with 221 = 2097 152 resolutions per rotation (360°), that is, corresponding to a 0.62″ signal period, achieved by the combination of a laser rotary encoder supplied by Magnescale Co., Ltd and a self-calibratable encoder (SelfA) supplied by The National Institute of Advanced Industrial Science & Technology (AIST). In addition, this paper introduces the development of a rotary encoder to guarantee ±0.03″ accuracy at any point of the interpolated signal, with respect to the encoder at the minimum resolution of 233, that is, corresponding to a 0.0015″ signal period after

  9. The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people – the relationship with the usage

    Mizuno M


    Full Text Available Makoto Mizuno,1,2 Kayo Kunimoto,1 Eiji Naru,2 Koichi Kameyama,2 Fukumi Furukawa,1 Yuki Yamamoto1,3 1Department of Dermatology, Wakayama Medical University, Wakayama, Japan; 2Fundamental Research Laboratories, KOSÉ Corporation, Tokyo, Japan; 3Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan Abstract: Since photoaging of skin is caused by chronic sun exposure, it is well-recognized that regular sunscreen use can help prevent photoaging of skin in fair-skinned people. Therefore, application of sunscreen is recommended for the prevention of photoaging in many countries. However, the relationship between UV exposure and photoaging has rarely been investigated in clinical studies in Japan. In addition, there have been almost no long-term interventional studies in Japanese people. We have previously conducted a study where Japanese actinic keratosis patients were instructed to continuously apply sunscreen. The results indicated that long-term application of sunscreen is effective in suppressing actinic keratosis progression and generation. In the present study, we investigated the effects of sunscreen on photoaged skin in 14 elderly Japanese people. Skin conditions such as water content, transepidermal water loss, the number of spots, wrinkles, and skin color tone uniformity were measured and compared before and after the study. A statistically significant difference was observed only in skin surface hydration. There were large inter-individual differences in amount of sunscreen used throughout the study. The changes in the number of spots and skin color tone uniformity during the 18 months showed good correlation with amount of sunscreen being used. These results suggest an increase in the number of spots and deterioration in skin color tone uniformity in the 18-month non-sunscreen application period, and that such skin conditions improved with increasing use of sunscreen. In this study, we suggested

  10. Liposomes and nanotechnology in drug development: focus on oncotargets

    Kozako T


    Full Text Available Tomohiro Kozako,1 Naomichi Arima,2 Makoto Yoshimitsu,3 Shin-Ichro Honda,1 Shinji Soeda11Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan; 2Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; 3Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, JapanAbstract: Nanotechnology is the development of an engineered device at the atomic, molecular, and macromolecular level in the nanometer range. Advances in nanotechnology have proven beneficial in therapeutic fields such as drug-delivery and gene/protein delivery. Antigen delivery systems are important for inducing and modifying immune responses. In cellular immunity, cytotoxic T lymphocytes (CTLs are important in the host defense against tumors. Key to the development of CTL-inducible vaccines is the ability to deliver antigens to antigen-presenting cells efficiently and to induce the subsequent activation of T cell-mediated immunity without adjuvants, as they can induce excessive inflammation leading to systemic febrile disease. Since expression and cloning methods for tumor-associated antigens have been reported, cancer vaccines that induce effective cell immunity may be promising therapeutic candidates, but Th2 cells are undesirable for use in cancer immunotherapy. Peptide vaccines have immunological and economic advantages as cancer vaccines because CTL epitope peptides from tumor-associated antigens have high antigen-specificity. However, cancer vaccines have had limited effectiveness in clinical responses due to the ability of cancer cells to “escape” from cancer immunity and a low efficiency of antigen-specific CTL induction due to immunogenic-free synthetic peptides. In contrast, carbohydrate-decorated particles such as carbohydrate-coated liposomes with encapsulated antigens might be more suitable as

  11. Usefulness of visual evaluation of the anterior thalamic radiation by diffusion tensor tractography for differentiating between Alzheimer’s disease and elderly major depressive disorder patients

    Niida A


    Full Text Available Akira Niida,1 Richi Niida,2 Kazumasa Kuniyoshi,3 Makoto Motomura,4 Akihiko Uechi51Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, Japan; 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, Japan; 3Department of Neuropathic Internal Medicine, Nanbu Hospital, Itoman City, Okinawa, Japan; 4Department of Human Sciences, University of the Ryukyus, Nakagami Country, Okinawa, Japan; 5Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, JapanBackground and objective: Many surveys of neural integrity of the cerebral white matter with psychiatric diseases on diffusion tensor imaging have recently been performed, but these mainly utilize fractional anisotropy (FA and the apparent diffusion coefficient (ADC values, and the results were inconsistent and not fully applied clinically. In this study, we investigated the possibility of differentiating between Alzheimer’s disease (AD and elderly major depressive disorder (MDD patients in whom early-stage symptoms are difficult to diagnose, by visually evaluating cerebral nerve fascicles utilizing diffusion tensor tractography. We also measured and evaluated FA and ADC values at the same time.Subjects and methods: The subjects included 13 AD patients (age: 69.5 ± 5.1 years, 19 MDD patients (65.8 ± 5.7 years, and 22 healthy control (HC subjects (67.4 ± 4.8 years. Images were acquired using a 1.5T magnetic resonance imaging device and analyzed by diffusion tensor tractography analysis software.Results: Depiction of the anterior thalamic radiation (ATR tended to be poor in AD patients unlike in MDD patients and HC subjects. The FA values in the left superior longitudinal fasciculus and fornix (FX in AD patients were significantly different from those in MDD patients and HC subjects. The ADC values in the bilateral ATR and left superior and inferior longitudinal fasciculi, left inferior fronto-occipital fasciculus, and FX in AD patients were

  12. Analysis of the presence or absence of atrophy of the subgenual and subcallosal cingulate cortices using voxel-based morphometry on MRI is useful to select prescriptions for patients with depressive symptoms

    Niida A


    Full Text Available Akira Niida,1 Richi Niida,2 Hiroshi Matsuda,3 Makoto Motomura,4 Akihiko Uechi5 1Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, Japan; 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, Japan; 3Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan; 4Department of Human Sciences, University of the Ryukyus, Nakagami County, Okinawa, Japan; 5Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, Japan Objective: We objectively evaluated the presence or absence of atrophy of the subgenual anterior cingulate cortex (sgACC and the subcallosal anterior cingulate cortex (scACC, using new voxel-based morphometry (VBM software employing Statistical Parametric Mapping software v8 and diffeomorphic anatomic registration through an exponentiated lie algebra. We prepared a database covering young-mature adulthood and investigated the clinical usefulness of the evaluation. Subjects and methods: One hundred seven patients with major depressive disorder (MDD, 74 patients with bipolar disorder (BD, and 240 healthy control subjects underwent 1.5T magnetic resonance imaging scanning. Using new VBM software and databases covering young-mature adults and the elderly, target volumes of interest were set in the sgACC and scACC, four indicators (severity, extent, ratio, and whole-brain extent were determined, and the presence or absence of atrophy of the sgACC and scACC was evaluated on the basis of the indicators. In addition, the relationships between the presence or absence of atrophy of the sgACC and scACC and performance of diagnosing MDD and BD and therapeutic drugs were investigated. Results: It was clarified that the disease is likely to be MDD when atrophy is detected in the sgACC, and likely to be BD when no atrophy is detected in the sgACC but is detected in the scACC. Regarding the relationship with therapeutic drugs, it was clarified that, when

  13. Diagnosis of depression by MRI scans with the use of VSRAD – a promising auxiliary means of diagnosis: a report of 10 years research

    Niida R


    Full Text Available Richi Niida1, Akira Niida2, Makoto Motomura3, Akihiko Uechi41Nanto Clinic, Urasoe City, Okinawa, Japan; 2Nanbu Hospital, Itoman City, Okinawa, Japan; 3University of the Ryukyus, Nakagami County, Okinawa, Japan; 4Kansai Gaidai University, Hirakata City, Osaka, JapanObjectives: This study was designed to evaluate the usefulness of assessing subgenual anterior cingulate cortex (sACC volume reduction by magnetic resonance imaging (MRI as an objective auxiliary means of diagnosis of depression. The study was additionally designed to analyze the association of sACC volume reduction with the effectiveness of treatments for depression and other diseases presenting with similar symptoms, and to examine the possibility of using sACC volume reduction in the distinction between depression and bipolar disorder and determining optimum medication for these conditions.Methods: Three-dimensional T1-weighted sagittal images, taken with Achieva 1.5T NOVA (Philips, were analyzed with VSRAD plus® to evaluate a reduction in sACC volume. The finding from this analysis was compared with the clinical data, including the longitudinal course follow-up data based on the treatment algorithm.Subjects: The study involved 88 patients aged over 54 who received MRI during 2010, ie, 71 patients with major depressive disorder (MDD, 11 patients bipolar disorder, and 6 patients in whom the initial diagnosis (MDD was later modified. Thirty-three normal individuals served as controls.Results: sACC volume reduction was noted in 66 of the 71 patients receiving treatment of MDD, with sensitivity of 93%, specificity of 85%, and accuracy of 90%. In the 66 patients diagnosed as having MDD and exhibiting sACC volume reduction, the disease showed remission in response to treatment with antidepressants, but medication needed to be continued after achievement of remission. In cases initially diagnosed as having MDD but not exhibiting sACC volume reduction, the necessity of modifying the

  14. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

    Miyazaki M


    Full Text Available Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan Background: Triple combination therapy involving long-acting muscarinic antagonists long-acting β2 agonists, and inhaled corticosteroids has recently become an option for maintenance treatment of COPD. Some add-on clinical trials have reported the benefits of these combinations. However, the process to step up to triple therapy varies for individual cases.Methods: Keio University and affiliated hospitals conducted an observational COPD cohort study, recruiting patients diagnosed as having COPD by pulmonary physicians and those referred for investigation of possible COPD. Their prescription history and clinical course were retrospectively analyzed based on the physicians’ medical records and patient questionnaires. This study was registered with UMIN (UMIN000003470, April 10, 2010.Results: A total of 95 of the 445 COPD patients (21% were treated with inhaled corticosteroids/long-acting β2 agonists/long-acting muscarinic antagonists as maintenance therapy, including 12 in COPD Grade I, 31 in Grade II, 38 in Grade III, and 14 in Grade IV, based on the Global Initiative for Chronic Obstructive Lung Disease spirometric grading. For more than half of the patients on triple therapy, the treatment had been intensified due to unsatisfactory improvement of symptoms, and 32% were treated with triple therapy due to comorbid asthma. In contrast, there were COPD patients whose therapy was

  15. Endoscopy-guided vitreoretinal surgery following penetrating corneal injury: a case report

    Motoko Kawashima


    Full Text Available Motoko Kawashima1, Shinichi Kawashima2, Murat Dogru1,3, Makoto Inoue4, Jun Shimazaki1,51Department of Ophthalmology, Tokyo Dental College, Chiba, Japan; 2Department of Ophthalmology, International University of Health and Welfare, Tokyo, Japan; 3Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan; 4Kyorin Eye Center, Tokyo, Japan; 5Department of Ophthalmology, Keio University School of Medicine, Tokyo, JapanIntroduction: Severe ocular trauma requires emergency surgery, and a fresh corneal graft may not always be available. We describe a case of perforating eye injury with corneal ­opacity, suspected endophthalmitis, and an intraocular foreign body. The patient was successfully treated with a two-step procedure comprising endoscopy-guided vitrectomy followed by corneal transplantation. This surgical technique offers a good option to vitrectomy with simultaneous keratoplasty in emergency cases where no graft is immediately available and there is the ­possibility of infection due to the presence of a foreign body.Case presentation: A 55-year-old Japanese woman was referred to our hospital with a ­perforating corneal and lens injury sustained with a muddy ferrous rod. Primary corneal sutures and lensectomy were performed immediately. Vitreoretinal surgery was required due to ­suspected endophthalmitis, vitreous hemorrhage, retinal detachment, dialysis and necrosis of the peripheral retina. Instead of conventional vitrectomy, endoscopy-guided vitreous surgery was performed with the Solid Fiber Catheter AS-611 (FiberTech, Tokyo, Japan due to the presence of corneal opacity and the unavailability of a donor cornea. The retina was successfully attached with the aid of a silicon oil tamponade. Following removal of the silicon oil at 3 months after surgery, penetrating keratoplasty and intraocular lens implantation with ciliary sulcus suture fixation were performed. At 6 months after penetrating

  16. Cost-effectiveness analysis of pregabalin for treatment of chronic low back pain in patients with accompanying lower limb pain (neuropathic component in Japan

    Igarashi A


    Full Text Available Ataru Igarashi,1 Manabu Akazawa,2 Tatsunori Murata,3 Toshihiko Taguchi,4 Alesia Sadosky,5 Nozomi Ebata,6 Richard Willke,5 Koichi Fujii,6 Jim Doherty,5 Makoto Kobayashi3 1Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; 2Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan; 3CRECON Medical Assessment Inc., Tokyo, Japan; 4Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; 5Pfizer Inc., New York, NY, USA; 6Pfizer Japan, Inc., Tokyo, Japan Objective: To assess the cost-effectiveness of pregabalin for the treatment of chronic low back pain with accompanying neuropathic pain (CLBP-NeP from the health care payer and societal perspectives. Methods: The cost-effectiveness of pregabalin versus usual care for treatment of CLBP-NeP was evaluated over a 12-month time horizon using the incremental cost-effectiveness ratio (ICER. Quality-adjusted life years (QALYs, derived from the five-dimension, five-level EuroQol (EQ-5D-5L questionnaire, was the measure of effectiveness. Medical costs and productivity losses were both calculated. Expected costs and outcomes were estimated via cohort simulation using a state-transition model, which mimics pain state transitions among mild, moderate, and severe pain. Distributions of pain severity were obtained from an 8-week noninterventional study. Health care resource consumption for estimation of direct medical costs for pain severity levels was derived from a physician survey. The ICER per additional QALY gained was calculated and sensitivity analyses were performed to evaluate the robustness of the assumptions across a range of values. Results: Direct medical costs and hospitalization costs were both lower in the pregabalin arm compared with usual care. The estimated ICERs in the base case scenarios were approximately ¥2,025,000 and ¥1,435,000 per

  17. Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma

    Yoshimitsu M


    Full Text Available Makoto Yoshimitsu, Naomichi Arima Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Abstract: Adult T-cell leukemia/lymphoma (ATLL is a peripheral T-cell lymphoma caused by latent infection of human T-cell lymphotropic virus type 1. The outcome for ATLL is very poor, with a 3-year overall survival of approximately 24% with conventional chemotherapy; thus, there is an unmet need for developing new treatment options. Defucosylated humanized anti-CC chemokine receptor 4 (CCR4 antibody (KW-0761, mogamulizumab has been clinically available for the treatment of relapsed or refractory ATLL in Japan since 2012, and a Phase II study of mogamulizumab for patients with relapsed CCR4+ ATLL demonstrated a 50% objective response, a 30.8% complete response, and an acceptable safety profile. Allogeneic hematopoietic stem cell transplantation has been used to treat patients with ATLL, and mogamulizumab in combination with allogeneic hematopoietic stem cell transplantation has been used successfully in a limited number of patients to treat refractory or relapsed ATLL. The efficacy of combining mogamulizumab with standard chemotherapy (mLSG15 for patients with ATLL has also been examined, and the results have shown higher rates of complete response with the combined therapy (52% compared with for chemotherapy alone (33%. Mogamulizumab also has potential application in the treatment of human T-cell lymphotropic virus type 1-associated myelopathy/tropical paraparesis, Epstein–Barr virus-associated T-cell and natural killer-cell lymphoproliferative diseases, and peripheral and cutaneous T-cell lymphomas. Possible adverse events of mogamulizumab have been reported, such as cutaneous adverse reactions (including Stevens–Johnson syndrome, diffuse panbronchiolitis, reactivation of hepatitis B, and opportunistic infections. The treatment outcome of patients

  18. Efficacy and visual prognostic factors of intravitreal bevacizumab as needed for macular edema secondary to central retinal vein occlusion

    Hirose M


    Full Text Available Miki Hirose, Wataru Matsumiya, Shigeru Honda, Makoto NakamuraDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, JapanPurpose: Our aim was to investigate the efficacy and prognostic factors of intraocular injections of bevacizumab as needed in patients with macular edema secondary to central retinal vein occlusion (CRVO.Methods: This is a retrospective study including 28 eyes of 27 consecutive patients with macular edema due to CRVO and followed for at least 6 months. The mean age of the patients was 66.3 years. The patients underwent an intravitreal injection of bevacizumab (1.25 mg at the initial visit. Retreatments were performed when macular edema was persistent or worsened (as-needed regimen. The primary outcome measure was the mean change in best-corrected visual acuity (BCVA. The change in central retinal thickness (CRT was evaluated as the secondary outcome. Finally, the factors useful for predicting BCVA outcome were determined.Results: The mean number of injections was 1.8 over a period of 6 months. The mean BCVA (logarithm of minimum angle of resolution was significantly improved at 1 (-0.097, 3 (-0.14, and 6 months (-0.25 after the initial injection (P<0.05, <0.01, and <0.001, respectively. The mean CRT was also improved significantly at 1 (-250.4, 3 (-150.0, and 6 months (-187.2 (P<0.001 each. Earlier treatment and better improvement in BCVA at 1 month after the initial treatment were the prognostic factors significantly associated with better visual outcomes at 6 months (P=0.047 and 0.029, respectively.Conclusion: Intravitreal injection of bevacizumab as needed significantly improved visual acuity and macular edema in CRVO patients. Time before the treatment and early response to the treatment were important factors for the visual outcome.Keywords: central retinal vein occlusion, bevacizumab, macular edema, efficacy, prognostic factor, pro re nata regimen

  19. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010)

    Takahashi, M.; Saito, H.


    Yanagihara, Yuta Toyoda and Eiji Kita Monte Carlo simulations of the magnetocaloric effect in magnetic Ni-Mn-X (X = Ga, In) Heusler alloys V D Buchelnikov, V V Sokolovskiy, S V Taskaev, V V Khovaylo, A A Aliev, L N Khanov, A B Batdalov, P Entel, H Miki and T Takagi Changes in electronic states and magnetic free energy in La1-zCez(FexSi1-x)13 magnetic refrigerants A Fujita, S Fujieda and K Fukamichi Garnet composite films with Au particles fabricated by repetitive formation for enhancement of Faraday effect H Uchida, Y Mizutani, Y Nakai, A A Fedyanin and M Inoue Control of magnetic domain wall displacement using spin current in small in-plane magnetic field in Permalloy nanowires Yoshihiko Togawa, Takashi Kimura, Ken Harada, Akira Tonomura and Yoshichika Otani Magnetic-field tunable transmittance in a ferrofluid-filled silicon nitride photonic crystal slab H M Lee, L Horng and J C Wu Evaluation of a miniature magnetostrictive actuator using Galfenol under tensile stress Toshiyuki Ueno, Hidemitsu Miura and Sotoshi Yamada Sub-nm resolution depth profiling of the magnetic structure of thin films by the depth-resolved x-ray magnetic circular dichroism technique K Amemiya and M Sakamaki

  20. PREFACE: Preface

    Audoin, Bertrand; Dehoux, Thomas; Guillet, Yannick


    and the gala dinner took place in a wine chateau in the medieval village. We hope this experience will remain in the attendees' memories as a pleasant and convivial time. We would like to express our thanks to the members of the organizing committee, the scientific committee, and all our generous sponsors, either institutions or companies, for their help in making this event possible. We would also like to thank the scientists involved for their confidence in our organization, and for their contributions. As unanimously decided by the attendees, the next symposium will be held in Japan, most likely in 2012. The papers published in this volume of the Journal of Physics: Conference Series provide a collection of state-of-the-art and recent advances in research and applications of laser ultrasonics as presented at this second Symposium. Bertrand Audoin - Conference ChairThomas Dehoux - Conference proceedings co-editorYannick Guillet - Conference proceedings co-editor Conference photograph Scientific committee Bertrand AudoinUniversité Bordeaux 1, France Alain BlouinNRC, Canada Christ GlorieuxKatholieke Universiteit Leuven, Belgium Vitalyi GusevUniversité du Maine, France Peter HessUniversity of Heidelberg, Germany Alexander A KarabutovMoscow State University, Russia Sridhar KrishnaswamyNorthwestern University, USA Humphrey MarisBrown University, USA Jean-Pierre MonchalinNRC, Canada Todd MurrayBoston University, USA Makoto OchiaiToshiba Corp, Japan Menglu QianTongji University, China Daniel RoyerEcole Supérieure de Physique et de Chimie, France Hervé TrétoutDassault Aviation, France Hubert VoillaumeEADS, France Oliver B WrightHokkaido University, Japan Shu-yi ZhangNanjing University, China Organizing committee Bertrand AudoinChair Sandrine GuitLocal administrator Christophe Aristégui Thomas Dehoux Evelyne Dewayse Yannick Guillet Armelle Guilloux

  1. PREFACE: 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) and 25th Symposium on Plasma Science for Materials (SPSM-25)

    Watanabe, Takayuki; Kaneko, Toshio; Sekine, Makoto; Tanaka, Yasunori


    advances in thermal and non-equilibrium plasmas as well as on more new and innovative developments in the field of life innovation, green innovation and a technical report session. The editors hope that this volume will be useful and helpful for deepening our understanding of science and technology of plasma materials processing and also for stimulating further development of the plasma technology. Finally, we would like to thank the conference chairmen, the members of the organizing committee, the advisory committee, the executive committee, the program committee, the publication committee, organizing secretariat and financial support from The 153rd Committee on Plasma Materials Science, JSPS. Sponsors and Supporting Organization: The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science Organizing Committee Chairperson: Osamu Tsuji, SAMCO Corporation, Japan Advisory Committee Chairperson: Akihisa Matsuda, Osaka University, Japan Executive Committee Chairperson: Masaru Hori, Nagoya University, Japan Program Committee Chairperson: Takamasa Ishigaki, Hosei University, Japan Publication Committee Chairperson: Takayuki Watanabe, Kyushu University Editors of APCPST-11 and SPMS-25 Professor Takayuki Watanabe, Kyushu University, Japan Professor Toshio Kaneko, Tohoku University, Japan Professor Makoto Sekine, Nagoya University, Japan Professor Yasunori Tanaka, Kanazawa University, Japan

  2. New and classical applications of heat flow studies

    Clauser, C.


    This special issue of Journal of Geophysics and Engineering is dedicated to a collection of papers which resulted from an international workshop held in Aachen, Germany, on 4-7 October 2004, called 'New and Classical Applications of Heat Flow Studies'. This was the third in a series of topical geothermal workshops arranged by the Geothermal Working Group of the German Geophysical Society (DGG) and was organized by the Institute of Applied Geophysics at RWTH Aachen University under the auspices of the International Heat Flow Commission of the International Association of Seismology and Physics (IASPEI). The meeting was attended by some 60 scientists from 14 countries and three continents. Financial assistance, granted by DGG and IASPEI, allowed us to provide partial support for a total of eight students, young scientists and eminent researchers from eastern Europe and overseas. The convenors of the meeting were Christoph Clauser (Aachen), Thomas Kohl (Zürich) and Makoto Taniguchi (Kyoto). The main local organizers were Volker Rath (scientific programme) and Ute Kreutz (accommodation and financial affairs). The topics addressed in more than 50 oral and poster presentations indicated that today intriguing new applications of heat flow studies have emerged, complementing the classical topics of heat flow mapping and the tectonic implications of heat flow. In classical applications, for instance, thermal signatures of water flow or downward diffusion of variations in the Earth's mean temperature are considered as noise which needs to be corrected prior to further use of the data. In contrast, in several new applications it is exactly the information contained in these signatures which has been extracted and interpreted. For instance, over the past two decades, work on the most prominent of these new applications has been devoted to inverting the variation of the Earth's past mean ground surface temperature (GST). As of today, GST provided by the geothermal method has

  3. Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder

    Niida A


    Full Text Available Akira Niida,1 Richi Niida,2 Hiroshi Matsuda,3 Takashi Inada,4 Makoto Motomura,5 Akihiko Uechi61Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, 3Department of Nuclear Medicine, Saitama Medical University International Medical Center, Hidaka City, Saitama, 4Department of Psychiatry, Kai Clinic, Naha City, Okinawa, 5Department of Human Sciences, University of the Ryukyu, Nakagami County, Okinawa, 6Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, JapanBackground: Despite being a very common psychiatric disorder, physicians often have difficulty making a diagnosis of major depressive disorder (MDD because, without established diagnostic criteria, they have to depend on interviews with patients and observation to assess psychiatric symptoms. However, previous researchers have reported that magnetic resonance imaging (MRI scans identify morphological changes in the brains of patients with MDD, which inspired us to hypothesize that assessment of local changes in the brain using voxel-based morphometry would serve as an auxiliary diagnostic method for MDD. Therefore, we focused on the VSRAD® plus (voxel-based specific regional analysis system for Alzheimer’s disease, a diagnostic support system for use in early Alzheimer’s disease, which allowed us to identify regional atrophy in the brain easily based on images obtained from MRI scans.Methods: The subjects were 75 patients with MDD, 15 with bipolar disorder, and 30 healthy subjects, aged 54–82 years. First, 1.5 T MRI equipment was used to scan three-dimensional T1-weighted images for the individual subjects, and the imaged data were analyzed by VSRAD advance (voxel-based morphometric software developed for diagnosis of early Alzheimer’s disease. The efficacy of the equipment for diagnosis of MDD was evaluated based on the distribution of atrophy in the subgenual anterior

  4. PREFACE: 26th Symposium on Plasma Science for Materials (SPSM-26)


    papers that are selected via strict peer-review process from full papers submitted for the proceedings of the conference. The topics range from basic physics and chemistry of plasma processing to a broad variety of materials processing and environmental applications. This proceeding offers an overview on the recent advances in thermal and non-equilibrium plasmas as well as the challenges ahead in the field of plasma research and applications among engineers and scientists. It is an honor to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. The editors hope that this proceeding will be useful and helpful for deepening our understanding of science and technology of plasma materials processing and also for stimulating further development of the plasma technology. Finally, I would like to thank the organizing committee and organizing secretariat of SPSM-26, and the participants of the conference for contribution to a successful and exciting meeting. The conference was chaired by Prof. Masaharu Shiratani, Kyushu University. I would also like to thank the financial support from The 153rd Committee on Plasma Materials Science. Editors of SPMS-26 Prof Takayuki Watanabe, Kyushu University, Japan Prof Makoto Sekine, Nagoya University, Japan Prof Takanori Ichiki, The University of Tokyo, Japan Prof Masaharu Shiratani, Kyushu University, Japan Prof Akimitsu Hatta, Kochi University of Technology, Japan Sponsors and Supporting Organization: The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science

  5. PREFACE: Asia-Pacific Interdisciplinary Research Conference 2011 (AP-IRC 2011)

    Sandhu, Adarsh; Okada, Hiroshi; Maekawa, Toru; Okano, Ken


    ; a novel method for the synthesis of graphene using bacteria extracted from a riverside in Toyohashi by Toyohashi Tech scientists; and ambitious plans to harvest energy by laying massive numbers of solar cells in North Africa as part of the 'Sahara Solar Breeder (SSB) Plan' for a global clean-energy superhighway, described by Hideomi Koinuma. In addition to the technical sessions, the conference banquet included a short session during which the invited speakers described notable trends in research and policy in their part of the world. The short speeches led to animated discussions between the delegates, particularly the young scientists and graduate students, who were able to talk directly with veteran researchers for a first-hand view of the issues raised during the day's presentations. In closing the conference, Professor Makoto Ishida, co-chair of the conference and vice-president of Toyohashi Tech announced that this conference will be held annually at the same time each year, with AP-IRC 2012 scheduled for 15-16 November 2012 at the Irago Sea-Park & Spa Hotel in Aichi Prefecture, Japan. AP-IRC group The PDF also contains lists of the Committees involved.

  6. PREFACE: The EPS High Energy Particle Physics Conference

    Barlow, Roger


    HEPP2007, the EPS High Energy Particle Physics Conference, was held in Manchester from July 19-26 2007. It brought together 580 delegates across the whole subject: from string theorists to detector technologists, from young postgraduate students to senior professors. Geographically they came from the UK, from the rest of Europe, from North America, and from the rest of the world. It covered the whole spectrum of the subject, not only accelerator-based experiments but also its astrophysical and cosmological aspects. The parallel and plenary talks can be found in these proceedings. A key feature of the conference, as always, was the award of the prizes: this year the EPS prize was awarded to Makoto Kobayashi and Toshihide Maskawa for their explanation of CP violation with a 6 quark model—Kobayashi came to accept it in person. The Gribov medal went to Niklas Beisert, the outreach prize to Richard Jacobsson and Charles Timmermans and the Young Physicist prizer to I Furic, G Gomez-Ceballos and S Menzemer. Parallel sessions were held in Manchester University, and plenary talks were held in the Bridgewater Hall in Manchester Town centre, a magnificent modern venue whose positive and co-operative staff enabled the conference to make the most of the impressive surroundings. We were able to put the hall to its proper purpose one evening with a concert by the Fairey Band—one of the distinctive brass bands who form part of the rich musical tradition of the North of England, and came as something new and different to many of the delegates. The conference ran smoothly and successfully, thanks largely to hard work by the local organising committee who devoted a lot of time to planning, producing ideas, and anticipating potential problems. Many of them were not from Manchester itself but from other universities and laboratories in the North of England, so their dedication was especially appreciated. The EPS committee also played a major part, by the selection of plenary

  7. Materials challenges and testing for supply of energy and resources

    Boellinghaus, Thomas; Lexow, Juergen (eds.) [Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin (Germany); Kishi, Teruo [National Inst. for Materials Science, Tsukuba, Ibaraki (Japan); Kitagawa, Masaki [Isobe Mihamaku, Chiba (Japan)


    Microscopy Studies on Oxide Dispersion Strengthened Steels (Arup Dasgupta); Fabrication of Probes for in-situ Mapping of Electrocatalytic Activity at the Nanoscale (Andrew J. Wain); Electrochemical Synthesis of Nanostructured Pd-based Catalyst and Its Application to On-Chip Fuel Cells (Satoshi Tominaka); Characterization and Synthesis of PtRu/C Catalysts for Possible Use in Fuel Cells (Eleanor Fourie); Synthesis and investigation of silver-peptide bioconjugates and investigation in their antimicrobial activity (Olga Golubeva); Characterization of Stabilized Zero Valent Iron Nanoparticles (Lauren F. Greenlee); Combustion Synthesis of Nanoparticles CeO{sub 2} and Ce{sub 0.9}Gd{sub 0.1}O{sub 1.95} (Sumittra Charojrochkul); Understandings of Solid Particle Impact and Bonding Behaviors in Warm Spray Deposition (Makoto Watanabe); Mechanical properties of innovative metal/ceramic composites based on freeze-cast ceramic performs (Siddhartha Roy); Mini-Samples Technique in Tensile and Fracture Toughness Tests of Nano-Structured Materials (Tomasz Brynk). The use of Focused Ion Beam to Build Nanodevices with Graphitic Structures (Braulio Archanjo); Brasil Development of compact continuous-wave terahertz (THz) sources by photoconductive mixing (Hendrix Tanoto); Electrical Impedance Characterization of Cement-Based Materials (Supaporn Wansom); On the Use of Indentation Technique as an Effective Method for Characterising starch-based food gels (Chaiwut Gamonpilas); Photothermal Radiometry applied in nanoliter melted tellurium alloys (Andrea Cappella). IV. Extraction and recovery of scarce elements and minerals - Biological Treatment of Solid Waste Materials from Copper and Steel Industry (Elina Merta).

  8. The Deep Carbon Cycle and CO2 Sequestration

    Filipovitch, N. B.; Mao, W. L.; Chou, I.; Mu, K.


    .G., Gormley, Deirdre, Nunez, Ryan, Carpenter, R.W., Squires, Kyle, Wolf, George, 2006, Carbon Sequestration via Aqueous Olivine Mineral Carbonation: Role of Passivating Layer Formation, Environ. Sci. Technol., Vol. 40, pp 4802-4808 3. Wolf, George H., Chizmeshya, Andrew V. G., Diefenbacher, Jason, McKelvy, Michael J., 2004, In Situ Observation of CO2 Sequestration Reactions Using a Novel Microreaction System, Environmental Science & Technology, Vol.38, No.3, pp 932-936 4. O’Connor, W. K., Dahlin, D. C., Nilsen, D.N., Rush, G.E., Walters, R.P., and Turner, P. C., 2000, “CO2 Storage in Solid Form: A Study of Direct Mineral Carbonation,” Proc. of the 5th International Conference on Greenhouse Gas Technologies, Cairns, Australia, August 14-18, pp. 1-7 5. Isshiki, Maiko, Irifune, Tetsuo, Hirose, Kei, Ono, Shigeaki, Ohishi, Yasuo, Watanuki, Tetsu, Nishibori, Eiji, Takata, Masaki, Sakata, Makoto, 2004, Stability of magnesite and its high-pressure form in the lowermost mantle, Nature, Vol. 427, pp. 60-63 6. Kawano, Jun, Miyake, Akira, Shimobayashi, Norimasa, Kitamura, Masao, 2009, Molecular dynamics simulation of the phase transition between calcite and CaCO3-II , Journal of Physics: Condensed Matter, Vol. 21, pp. 1-11

  9. PREFACE: Dynamics of low-dimensional systems Dynamics of low-dimensional systems

    Bernasconi, M.; Miret-Artés, S.; Toennies, J. P.


    Chulkov Surface phonons on Pb(111) I Yu Sklyadneva, R Heid, K-P Bohnen, P M Echenique and E V Chulkov Using evidence from nanocavities to assess the vibrational properties of external surfaces G F Cerofolini, F Corni, S Frabboni, G Ottaviani, E Romano, R Tonini and D Narducci Magnetic properties and relaxation dynamics of a frustrated Ni7 molecular nanomagnet E Garlatti, S Carretta, M Affronte, E C Sañudo, G Amoretti and P Santini A theoretical study of rotational and translational diffusion dynamics of molecules with a six-fold point symmetry adsorbed on a hexagonal lattice by neutron scattering I Calvo-Almazán, S Miret-Artés and P Fouquet Vibrational dynamics and surface structure of Bi(111) from helium atom scattering measurements M Mayrhofer-Reinhartshuber, A Tamtögl, P Kraus, K H Rieder and W E Ernst Double and triple ionization of silver clusters by electron impactAvik Halder, Anthony Liang, Chunrong Yin and Vitaly V Kresin Scattering of O2 from a graphite surface W W Hayes, Junepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura and J R Manson Zero-phonon lines of systems with different dimensions and unconventional vibronic interactions V Hizhnyakov A kinetic Monte Carlo approach to investigate antibiotic translocation through bacterial porins Matteo Ceccarelli, Attilio V Vargiu and Paolo Ruggerone Quantum Zeno and anti-Zeno effects in surface diffusion of interacting adsorbates H C Peñate-Rodrìguez, R Martìnez-Casado, G Rojas-Lorenzo, A S Sanz and S Miret-Artés Weakly bound finite systems: (4He)N-Rb2(3Σu), clustering structures from a quantum Monte Carlo approach D López-Durán, R Rodrìguez-Cantano, T González-Lezana, G Delgado-Barrio, P Villarreal, E Yurtsever and F A Gianturco Multiphonon atom-surface scattering from corrugated surfaces: derivation of the inelastic scattering spectrum for diffraction statesBranko Gumhalter Probing the non-pairwise interactions between CO molecules moving on a Cu(111) surfacePepijn R Kole, Holly

  10. EDITORIAL: From reciprocal space to real space in surface science From reciprocal space to real space in surface science

    Bartels, Ludwig; Ernst, Karl-Heinz


    Triest.let's finish—aus basta Some move atoms around to hear how they sound.Karl-Heinz Rieder, Erice, 6 April 1998 From reciprocal space to real space in surface science contents From reciprocal space to real space in surface scienceLudwig Bartels and Karl-Heinz Ernst Karl-Heinz Reider: the quiet pioneerGiorgio Benedek Scattering of CO and N2 molecules by a graphite surfaceJunepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura, W W Hayes and J R Manson Helium, neon and argon diffraction from Ru(0001)M Minniti, C Díaz, J L Fernández Cuñado, A Politano, D Maccariello, F Martín, D Farías and R Miranda Enhanced charge transfer in a monolayer of the organic charge transfer complex TTF-TNAP on Au(111)T R Umbach, I Fernandez-Torrente, J N Ladenthin, J I Pascual and K J Franke Extended pattern recognition scheme for self-learning kinetic Monte Carlo simulationsSyed Islamuddin Shah, Giridhar Nandipati, Abdelkader Kara and Talat S Rahman Acetylene on Cu(111): imaging a molecular surface arrangement with a constantly rearranging tipYeming Zhu, Jonathan Wyrick, Kamelia D Cohen, Katie Marie Magnone, Connor Holzke, Daniel Salib, Quan Ma, Dezheng Sun and Ludwig Bartels Coulomb attraction during the carpet growth mode of NaClFriederike Matthaei, Sarah Heidorn, Konrad Boom, Cord Bertram, Ali Safiei, Jörg Henzl and Karina Morgenstern Molecular self-assembly on an insulating surface: interplay between substrate templating and intermolecular interactionsMarkus Kittelmann, Philipp Rahe and Angelika Kühnle Vertical manipulation of native adatoms on the InAs(111)A surfaceJ Yang, C Nacci, J Martínez-Blanco, K Kanisawa and S Fölsch Charge transfer between isomer domains on n+-doped Si(111)-2 × 1: energetic stabilizationR M Feenstra, G Bussetti, B Bonanni, A Violante, C Goletti, P Chiaradia, M G Betti and C Mariani Probing the properties of metal-oxide interfaces: silica films on Mo and Ru supportsLeonid Lichtenstein, Markus Heyde, Stefan Ulrich, Niklas Nilius

  11. EDITORIAL: Flexible OLEDs and organic electronics Flexible OLEDs and organic electronics

    Kim, Jang-Joo; Han, Min-Koo; Noh, Yong-Young


    as one of the best candidates for the purpose, and J K Jeong discusses their status and perspectives. Next, several excellent research articles on OFETs follow. In particular, Y-Y Noh et al introduce an interesting method to control charge injection in top-gated OFETs by insertion of various self-assembled monolayers in their paper entitled 'Controlling contact resistance in top-gate polythiophene-based field-effect transistors by molecular engineering'. We would like to thank all the authors for their contributions, which combine new results and profound overviews of the state of the art in flexible OLEDs and organic electronics areas; it is this combination that most often adds to the value of topical issues. Special thanks also go to the staff of IOP Publishing, particularly Ms Alice Malhador, for contributing to the success of this effort. In this special issue, many wonderful reviews and research articles provide a detailed overview of recent progress in OLEDs, OPVs and OFETs as well as a scientific understanding of the device physics with these materials. We sincerely believe this special issue is a timely publication and will give productive information to a broad range of readers. Flexible OLEDs and organic electronics Contents Thin film encapsulation for flexible AM-OLED: a review Jin-Seong Park, Heeyeop Chae, Ho Kyoon Chung and Sang In Lee Large-area OLED lightings and their applications J W Park, D C Shin and S H Park Controlling contact resistance in top-gate polythiophene-based field-effect transistors by molecular engineering Yong-Young Noh, Xiaoyang Cheng, Marta Tello, Mi-Jung Lee and Henning Sirringhaus Branched polythiophene as a new amorphous semiconducting polymer for an organic field-effect transistor Makoto Karakawa, Yutaka Ie and Yoshio Aso Influence of mechanical strain on the electrical properties of flexible organic thin-film transistors Fang-Chung Chen, Tzung-Da Chen, Bing-Ruei Zeng and Ya-Wei Chung Frequency operation of low

  12. NRAO Scientists on Team Receiving International Astronautics Award


    , a radio telescope bigger than the Earth." In addition to Fomalont and Romney, they are: Hisashi Hirabayashi, of the Institute of Space and Astronautical Science and Japan Aerospace Exploration Agency (ISAS/JAXA), Haruto Hirosawa (ISAS/JAXA), Peter Dewdney of Canada's Dominion Radio Astrophysical Observatory, Leonid Gurvits of the Joint Institute for VLBI in Europe (JIVE, The Netherlands), Makoto Inoue of the National Astronomical Observatory of Japan (NAOJ), David Jauncey of the Australia Telescope National Facility, Noriyuki Kawaguchi (NAOJ), Hideyuki Kobayashi (NAOJ), Kazuo Miyoshi (Mitsubishi Electric Corporation, Japan), Yasuhiro Murata (ISAS/JAXA), Takeshi Orii (NEC, Japan) Robert Preston of NASA's Jet Propulsion Laboratory (JPL), and Joel Smith (JPL). The International Academy of Astronautics was founded in August 1960 in Stockholm, Sweden, during the 11th International Astronautical Congress. The Academy aims to foster the development of astronautics for peaceful purposes; recognize individuals who have distinguished themselves in a related branch of science or technology; provide a program through which members may contribute to international endeavours; cooperation in the advancement of aerospace science. Previous recipients of the Laurels for Team Achievement Award are the Russian Mir Space Station Team (2001), the U.S. Space Shuttle Team (2002), the Solar and Heliospheric Observatory (SOHO) Team (2003), and the Hubble Space Telescope Team (2004). The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  13. Extraordinary Cosmic Laboratory Helps Unravel Mysteries of a Galaxy's Powerful Central "Engine"

    National Radio Astronomy Observatory in Socorro, NM; Mikoto Miyoshi of Japan's Misusawa Astrogeodynamics Observatory; and Naomasa Nakai and Makoto Inoue of Japan's Nobeyama Radio Observatory. The work formed the basis of Herrnstein's Ph.D. dissertation at Harvard University. The extraordinary detail of the observations is made possible by the fact that the water molecules in the disk orbiting the black hole are amplifying microwave radio emissions in the same manner that a laser amplifies light. These natural amplifiers are called cosmic masers, and they produce bright targets for radio telescopes. Study of water masers at the center of NGC 4258 is what revealed the orbiting disk in 1994. Further studies of the water masers in NGC 4258 now have allowed the research team to deduce the exact location of the object orbited by the disk. In addition, new observations of the galaxy's center show radio emission the astronomers believe traces the inner parts of the high-speed jets. Combined, these new observations allow measurement of the distance between the black hole and the innermost observable portions of the jets. Such measurement is extremely important, because the standard theoretical model, proposed in 1979 by Roger Blandford of Caltech and Arieh Konigl of the University of Chicago, makes a clear prediction that all detected radio emission will be offset from the central engine generating the jets. The new radio observations of NGC 4258 are the first to show the exact location of the core of an AGN, and thus the first to allow measurement of the offset between the core and the detected emission closest to it. Significantly, the offset measured in NGC 4258 is fully consistent with the quantitative prediction made by the model of Blandford and Konigl. "There has been a lot of speculation about the relationship between radio jets and black holes over the years," said Herrnstein. "But this measurement precisely pins down the geometric relationship between them in this object

  14. Immunotherapy: A breakthrough in cancer research

    Editorial Office


    test the effectiveness of the tuberculosis vaccine Bacille Calmette-Guérin (BCG in treating superficial bladder cancer. The BCG treatment, in which BCG bacilli are inserted directly into a patient’s bladder via a catheter, proved to be an effective form of immunotherapy and the groundbreaking technique is still used today. In general, studies on immunotherapy have presented researchers with two important conclusions: First and foremost, researchers were finally able to prove that the immune system is indeed capable of recognizing cancer cells as a ‘foreign entity’ although they originate from the body’s own tissues. Secondly, by boosting the immune response, researchers are able to enhance other cancer-killing agents at the same time, thus increasing the chances of a successful treatment via immunotherapy. Based on these conclusions, researchers all over the world now face the challenge of figuring out which therapy works best for a specific type of cancer and why some cancer patients respond better than others to the prescribed treatments.At the ESMO Asia 2016 congress, lead author Dr. Makoto Tahara presented his paper ‘Asian head and neck cancer patients live longer with immunotherapy than mixed race group’, in which his team of researchers reported the sub-analysis results on the safety and efficacy of pembrolizumab in 26 patients (of Asian Pacific origin who received a fixed dose of the humanized antibody for 24 months until the detection of disease progression or adverse events. They observed that both the median overall survival and the disease control rate were better in Asians than the overall population, i.e. 11.5 versus 8.4 months and 50.5% versus 37.9%, respectively.According to Dr. Tahara, “The fixed dose of pembrolizumab was well-tolerated in Asian Pacific patients with recurrent/metastatic head and neck cancer. Although the Asian population was small, our findings suggest that they have better median overall survival with pembrolizumab than

  15. Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.

    Nakata, M; Tang, W


    research in Asian countries. (reported on October 1st, with grateful thanks to all participants) Main program Session I. Research Advances in Drug Discoveries and Therapeutics ● Design, synthesis and preliminary activity assay of influenza virus neuraminidase inhibitors by Wenfang Xu (Shandong University, China) ● Infection disease models with silkworms to evaluate the therapeutic effects of drug candidates by Kazuhisa Sekimizu (The University of Tokyo, Japan) ● Japan's governmental approaches to facilitate drug development process by Makoto Shimoaraiso (Ministry of Foreign Affairs of Japan, Japan) ● Effective detection of the epidermal growth factor receptor mutation by the peptide nucleic acid-locked nucleic acid PCR Clamp by Sakuo Hoshi (The University of Tokyo Hospital, Japan) ● Design and synthesis of p53-MDM2 binding inhibitors by Yongzhou Hu (Zhejiang University, China) Session II. Drug Synthesis/Clinical Therapeutics ● Pharmacogenomics-based clinical studies using a novel fully-automated genotyping system by Setsuo Hasegawa (Sekino Clinical Pharmacology Clinic, Japan) ● Synthesis and biological evaluation of pentacyclic triterpenes as anti-tumor agents by Hongbin Sun (China Pharmaceutical University, China) ● Drug discovery and therapeutics using silkworm as experimental animal by Yasuyuki Ogata (The University of Tokyo, Japan) ● Novel selective estrogen recetpor modulators (SERMs) with unusual structure and biological activities by Haibing Zhou (Wuhan University, China) Session III. Medicinal Chemistry/Natural Products ● Synthesis and properties of isonucleosides incorporated oligonucleotides by Zhenjun Yang (Peking University, China) ● Isolation of antiviral compounds from plant resources using silkworm bioassay by Yutaka Orihara (The University of Tokyo, Japan) ● Synthesis and structural modifcation of tasiamide and the effect of these modifications on in vitro anticancer activity by Yingxia Li (Ocean University of China, China)

  16. Quantification and Negation in Event Semantics

    Lucas Champollion


    analogies between tenses and pronouns in English’. The Journal of Philosophy 70: 601–609., Barbara H. 1987. ‘Noun phrase interpretation and type-shifting principles’. In Jeroen Groenendijk, Dick de Jongh & Martin Stokhof (eds. ‘Studies in Discourse Representation Theory and the Theory of Generalized Quanti?ers’, 115–143. Dordrecht, Netherlands: Foris.Rathert, Monika. 2004. Textures of time. Berlin, Germany: Akademie Verlag.Smith, Steven Bradley. 1975. Meaning and negation. The Hague, Netherlands: Mouton.von Stechow, Arnim. 2009. ‘Tenses in compositional semantics’. In Wolfgang Klein & Ping Li (eds. ‘The expression of time’, 129–166. Berlin, Germany: Mouton de Gruyter.Winter, Yoad & Zwarts, Joost. 2011. ‘Event semantics and Abstract Categorial Grammar’. In Makoto Kanazawa, Marcus Kracht & Hiroyuki Seki (eds. ‘Proceedings of Mathematics of Language 12’, Lecture Notes in Computer Science / Lecture Notes in Arti?cial Intelligence, vol. 6878, 174–191. Berlin / Heidelberg: Springer.Zucchi, Sandro & White, Michael. 2001. ‘Twigs, sequences and the temporal constitution of predicates’. Linguistics and Philosophy 24: 187–222.

  17. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.


    , France) Michael Mueller (, Cagliari, Italy) Mario Nadalini (Università di Trento, Italy) José Navarro-Salas (Universidad de Valencia, Spain) Jeanette E. Nelson (Università di Torino, Italy) Alexander Nesterov (Universidad de Guadalajara, Mexico) Hermann Nicolai (Albert-Einstein-Institut, Golm, Germany) Daniele Oriti (DAMTP, University of Cambridge, UK) Marcello Ortaggio (Charles University, Prague, Czech Republic) Silvio Pallua (University of Zagreb, Croatia) Matej Pavsic (Jozef Stefan Institute, Ljubljana, Slovenia) Wlodzimierz Piechocki (Soltan Inst. for Nuclear Studies, Warsaw, Poland) Nicola Pinamonti (Università di Trento, Italy) J. Brian Pitts (University of Notre Dame, Indiana, USA) Vojtech Pravda (Academy of Sciences, Praha, Czech Rep.) Gianpaolo Procopio (DAMTP, University of Cambridge, UK) Alice Rogers (King's College London, UK) Efrain Rojas (Universidad Veracruzana, Mexico) James Ryan (DAMTP, University of Cambridge, UK) Augusto Sagnotti (Università di Roma Tor Vergata, Italy) Wenceslao Santiago-German (University of California at Davis, USA) Stefano Sciuto (Università di Torino, Italy) Domenico Seminara (Università di Firenze, Italy) Lorenzo Sindoni (Università di Udine, Italy) Kellogg S. Stelle (Imperial College, London, UK) Cosimo Stornaiolo (INFN, Sezione di Napoli, Italy) Ward Struyve (Perimeter Institute, Waterloo, Canada) Makoto Tanabe (Waseda University, Tokyo, Japan) Daniel Terno (Perimeter Institute, Waterloo, Canada) Charles Wang (Lancaster University, UK) Silke Weinfurtner (Victoria University, Wellington, New Zealand) Hans Westman (Perimeter Institute, Waterloo, Canada) Ruth Williams (DAMTP, University of Cambridge, UK) Tetsuyuki Yukawa (Graduate U. for Adv. Studies, Kanagawa, Japan) Jorge Zanelli (CECS, Santiago, Chile)