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Sample records for yong zhi wu

  1. Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

    Directory of Open Access Journals (Sweden)

    Shiuan-Pey Lin

    2011-01-01

    Full Text Available Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomically related to grapefruit and pomelo, are in wide use in clinical Chinese medicine. To investigate the possible interaction of these two Citrus herbs with tacrolimus, male Sprague-Dawley rats were orally given tacrolimus (1.5 mg/kg with and without Zhi Ke and Zhi Shi decoctions in a cross-over design. Blood samples were withdrawn via cardiopuncture at specific time and quantitated by a microparticle enzyme immunoassay. In addition, to explore the mechanism of interaction, LS 180 cell line was used for the transport study of rhodamine 123, a typical substrate of P-glycoprotein (P-gp. The results showed that Zhi Shi significantly decreased the Cmax⁡ and AUC0-t of tacrolimus by 72.4% and 72.0%, respectively, whereas Zhi Ke did not affect tacrolimus pharmacokinetics. LS 180 cell line study indicated that Zhi Shi increased the efflux activity of P-gp, enabling us to explain the decreased oral bioavailability of tacrolimus caused by Zhi Shi. Hence, we suggest that Zhi Shi be contraindicated for transplant patients treated with tacrolimus to reduce the risk of allograft rejection.

  2. Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

    Science.gov (United States)

    Lin, Shiuan-Pey; Wu, Ping-Ping; Hou, Yu-Chi; Tsai, Shang-Yuan; Wang, Meng-Ju; Fang, Shih-Hua; Chao, Pei-Dawn Lee

    2011-01-01

    Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomically related to grapefruit and pomelo, are in wide use in clinical Chinese medicine. To investigate the possible interaction of these two Citrus herbs with tacrolimus, male Sprague-Dawley rats were orally given tacrolimus (1.5 mg/kg) with and without Zhi Ke and Zhi Shi decoctions in a cross-over design. Blood samples were withdrawn via cardiopuncture at specific time and quantitated by a microparticle enzyme immunoassay. In addition, to explore the mechanism of interaction, LS 180 cell line was used for the transport study of rhodamine 123, a typical substrate of P-glycoprotein (P-gp). The results showed that Zhi Shi significantly decreased the C max and AUC0−t of tacrolimus by 72.4% and 72.0%, respectively, whereas Zhi Ke did not affect tacrolimus pharmacokinetics. LS 180 cell line study indicated that Zhi Shi increased the efflux activity of P-gp, enabling us to explain the decreased oral bioavailability of tacrolimus caused by Zhi Shi. Hence, we suggest that Zhi Shi be contraindicated for transplant patients treated with tacrolimus to reduce the risk of allograft rejection. PMID:21318106

  3. Individual Differences in Zhong-Yong tendency and Processing Capacity

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    Ting-Yun eChang

    2014-11-01

    Full Text Available The present study investigated how an individual’s Zhong-Yong tendency is related to his/her perceptual processing capacity. In two experiments, participants completed a Zhong-Yong Thinking Style Scale and performed a redundant-target detection task. Processing capacity was assessed with a nonparametric approach (systems factorial technology, SFT and a parametric (linear ballistic accumulator model, LBA approach. Results converged to suggest a positive correlation between Zhong-Yong tendency and processing capacity. High middle-way thinkers had larger processing capacity in multiple-signal processing compared with low middle-way thinkers, indicating that they processed information more efficiently and in an integrated fashion. Zhong-Yong tendency positively correlates with the processing capacity. These findings suggest that the individual differences in processing capacity can account for the reasons why high middle-way thinkers tend to adopt a global and flexible processing strategy to deal with the external world. Furthermore, the influence of culturally dictated thinking style on cognition can be revealed in a perception task.

  4. Zhong-Yong as Dynamic Balancing Between Yin-Yang Opposites

    DEFF Research Database (Denmark)

    Li, Xin

    2018-01-01

    of Zhong-Yong balancing being incorrect and incomplete, the author proposes an alternative perspective on Zhong-Yong as dynamic balancing between Yin-Yang opposites. Design/methodology/approach: The author first explain why Peter P. Li’s “asymmetry” and “superiority” arguments are flawed by referring...... to the original text of the classical book of Zhong-Yong (中庸) and a comparison between Zhong-Yong and Aristotle’s doctrine of the mean. The author then propose an alternative approach to Zhong-Yong balancing that is embedded in the original text Zhong-Yong but somehow has been neglected by many Chinese scholars...

  5. On Li Zhi's Theory of Growing up in Spirit

    Institute of Scientific and Technical Information of China (English)

    Wang Junjiang

    2006-01-01

    The theory of growing up in spirit is the core of Li Zhi's thought.The theory attempts to get rid of the limit of the rigid ethical doctrine of Confucianismand to encourage growth in a helpful person for the benefit of the country,which demands both a free environment of society and enough courage and insight of the individual.At the same time,the criterion of growing up in spirit indicates the limitation of Li Zhi's thought.His free exploration,however,provides various revelations for us.

  6. Wu Chien-Shiung: A brief biography

    Science.gov (United States)

    Chiang, Tsai-Chien

    2015-12-01

    My first encounter with professor Wu Chien-Shiung, a leading experimental physicist, 31 years ago inspired me to write her biography. I received much encouragement when planning this biography, especially from Dr. Yang Chen Ning, whose biography I wrote later. The real challenges in writing Wu's biography were finding the balance between both sides of her life and overcoming the obstacle that, unlike theoretical physicists (such as Yang), experimental physicists are inclined more to deeds than to words.

  7. [Professor WU Zhongchao's experience of penetration needling].

    Science.gov (United States)

    Zhang, Ning; Wang, Bing; Zhou, Yu

    2016-08-12

    Professor WU Zhongchao has unique application of penetration needling in clinical treatment. Professor WU applies penetration needling along meridians, and the methods of penetration needling include self-meridian penetration, exterior-interior meridian penetration, identical-name meridian penetration, different meridian penetration. The meridian differentiation is performed according to different TCM syndromes, locations and natures of diseases and acupoint nature, so as to make a comprehensive assessment. The qi movement during acupuncture is focused. In addition, attention is paid on anatomy and long-needle penetration; the sequence and direction of acupuncture is essential, and the reinforcing and reducing methods have great originality, presented with holding, waiting, pressing and vibrating. Based on classical acupoint, the acupoint of penetration needling is flexible, forming unique combination of acupoints.

  8. Non-minimal Wu-Yang monopole

    International Nuclear Information System (INIS)

    Balakin, A.B.; Zayats, A.E.

    2007-01-01

    We discuss new exact spherically symmetric static solutions to non-minimally extended Einstein-Yang-Mills equations. The obtained solution to the Yang-Mills subsystem is interpreted as a non-minimal Wu-Yang monopole solution. We focus on the analysis of two classes of the exact solutions to the gravitational field equations. Solutions of the first class belong to the Reissner-Nordstroem type, i.e., they are characterized by horizons and by the singularity at the point of origin. The solutions of the second class are regular ones. The horizons and singularities of a new type, the non-minimal ones, are indicated

  9. On soliton solutions of the Wu-Zhang system

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    Inc Mustafa

    2016-01-01

    Full Text Available In this paper, the extended tanh and hirota methods are used to construct soliton solutions for the WuZhang (WZ system. Singular solitary wave, periodic and multi soliton solutions of the WZ system are obtained.

  10. [Data mining analysis of professor Li Fa-zhi AIDS itchy skin medical record].

    Science.gov (United States)

    Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

    2013-08-01

    Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of itchy skin, provide the corresponding drug reference basis for Chinese medicine treatment of AIDS, skin itching. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS patients with skin pruritus, etiology and pathogenesis analysis, skin itching AIDS syndrome differentiation of old Chinese medicine treatment and medication rule. The use of multi-dimensional query analysis, core drug skin itching AIDS treatment in this study as a windbreak, cicada slough, bupleurum, Qufeng solution table drug, licorice detoxification efficacy of drugs, Radix Scutellariae, Kochia scoparia, clearing away heat and promoting diuresis medicine; core prescription for Jingfang San streak virus. Professor Li Fa-zhi treatment of AIDS in the skin itching Qufeng solution table dehumidification antipruritic treatment.

  11. Lightcurve and Rotation Period Determinations for 1599 Giomus and 1888 Zu Chong-Zhi

    Science.gov (United States)

    Foylan, Mike; Rowe, Basil; Smith, Kevin Stephen

    2018-04-01

    Collaborative CCD photometric observations of mainbelt asteroids 1599 Giomus (1950 WA) and 1888 Zu Chong-Zhi (1964 VO1) were acquired during 2017 November and December. A rotation period of 9.53 ± 0.03 h and amplitude of A = 0.06 ± 0.05 mag were determined for 1599 Giomus and 11.053 ± 0.003 h and amplitude of A = 0.56 ± 0.05 mag were determined for 1888 Zu Chong-Zhi.

  12. Yin Zhi Huang and other plant-derived preparations: where herbal and molecular medicine meet

    NARCIS (Netherlands)

    Elferink, Ronald Oude

    2004-01-01

    Yin Zhi Huang, a decoction of Yin Chin (Artemisia capillaris) and three other herbs, is widely used in Asia to prevent and treat neonatal jaundice. We recently identified the constitutive androstane receptor (CAR, NR113) as a key regulator of bilirubin clearance in the liver. Here we show that

  13. Zhong-Yong as Dynamic Balancing Between Yin-Yang Opposites

    DEFF Research Database (Denmark)

    Li, Xin

    2017-01-01

    Purpose The purpose of this paper is to comment on Peter Ping Li’s understanding of Zhong-Yong balancing, presented in his article titled “Global implications of the indigenous epistemological system from the East: How to apply Yin-Yang balancing to paradox management.” Seeing his understanding....... Originality/value This commentary contributes to the “West meets East” discourse by debunking Peter P. Li’s assertion that Yin-Yang balancing is superior as a solution to paradox management and his prescription that balancing between Yin-Yang opposites must be asymmetric. It also contributes to the Chinese...

  14. [The essence of Professor Wu Lian-Zhong's acupuncture manipulation].

    Science.gov (United States)

    Liu, Jing; Guo, Yi; Wu, Lian-Zhong

    2014-05-01

    The painless needle insertion technique, summarized by Professor WU Lian-zhong during his decades of acupuncture clinical practice is introduced in this article, which is characterized as soft, flexible, fast, plucking and activating antipathogenic qi. The Sancai (three layers) lifting and thrusting manipulation technique is adopted by Professor WU for getting the qi sensation. And features of 10 kinds of needling sensation such as soreness, numbness, heaviness, distension, pain, cold, hot, radiation, jumping and contracture are summarized. Finger force, amplitude, speed and time length are also taken as the basis of reinforcing and reducing manipulations. Moreover, examples are also given to explain the needling technique on some specific points which further embodies Professor WU's unique experiences and understandings on acupuncture.

  15. Wu-Ling-San formula prophylaxis against recurrent calcium oxalate ...

    African Journals Online (AJOL)

    Wu-Ling-San (WLS) formula has been proved to prevent calcium oxalate nephrolithiasis both in vitro and in vivo. This is the first prospective, randomized and placebo-controlled clinical trial of WLS in calcium oxalate nephrolithiasis prevention. All patients who enrolled were asked to drink enough fluid to urinate at least 2 L ...

  16. Valores, Creencias Y Objectivos: Base del programa de la Escuela Experimental P.K. Yonge. (Values, Beliefs and Objectives: The Basis of Experimental Schools P.K. Yonge's Program.)

    Science.gov (United States)

    Florida Univ., Gainesville. Coll. of Education.

    The values, beliefs, and objectives that form the core of the program at the Experimental School P.K. Yonge in the University of Florida are presented in this paper which is written in Spanish. This experimental school serves approximately 900 students from grades one through twelve. The function of the school is to conduct research to solve…

  17. Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS

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    Saifei Li

    2016-04-01

    Full Text Available Ling-zhi is a medicinal herb that generally refers to a fungus in the genus Ganoderma. It has been used as a medicinal mushroom in traditional Chinese medicine for more than 2000 years. Mycologists at the Institute of Microbiology, Chinese Academy of Sciences (IMCAS first artificially cultivated the Ling-zhi fruiting body in the late 1960s (X.J. Liu’s team. In IMCAS, different research teams have extensively studied Ling-zhi in the aspects of national resource surveys, systematic taxonomy, chemical analysis, and processing for medicinal and health applications. The research results from IMCAS have provided essential support and prompted the development of the Ling-zhi industry in China to some extent. This review aims to summarize the history of research on Ling-zhi in IMCAS and its role in the development of the Ling-zhi economy.

  18. [Data mining analysis of professor Li Fa-zhi AIDS herpes zoster medical record].

    Science.gov (United States)

    Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

    2013-08-01

    Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of herpes zoster and postherpetic neuralgia, provide reference for the use of Chinese medicine treatment of AIDS, herpes zoster and postherpetic neuralgia. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS of herpes zoster and postherpetic neuralgia patients, patients are input structured clinical information collection system, into the analysis of the data, carries on the research analysis theory of traditional Chinese medicine compatibility system algorithm and complex network analysis the use of complex networks. The use of multi-dimensional query analysis of AIDS drugs, the core of herpes zoster and postherpetic neuralgia treated in this study are Scutellariae Radix, Glucyrrhizae Radix, Carthame Flos, Plantaginis Semen, Trichosamthis Fructus, Angelicae Sinensis Radix, Gentianae Radix; core prescription for Longdan Xiegan decoction and Trichosanthes red liquorice decoction. Professor Li Fa-zhi treatment of AIDS, herpes zoster and postherpetic neuralgia by clearing heat and removing dampness and activating blood circulation to.

  19. Towards a Collective Intelligence: Transmediality and the Wu Ming Project

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    Melina Anne Masterson

    2014-11-01

    Full Text Available Dagli albori della Seconda Repubblica in Italia,  le strategie di dominio sui mass media dell’ex premier Silvio Berlusconi hanno avuto un effetto considerevole sull’immaginario culturale italiano. In un approccio multisensoriale e multimediale alla scrittura, il collettivo Wu Ming mette in questione i paradigmi culturali che negli ultimi venti anni sono diventati egemonici. L’esperienza di un romanzo dei Wu Ming va ben oltre la parola stampata poiché cerca di stimolare tutti i cinque sensi per arricchire il modo in cui il lettore vive quello che c’è sulla pagina, dimostrando esempi chiari della «convergence culture» coniata da Henry Jenkins. Questo saggio esamina l’interazione tra parola e immagine messa in atto dal collettivo tramite il sito Pinterest e illustra come questo aspetto del loro progetto rappresenti un microcosmo di un approccio complessivo alla creazione estetica e alla pratica culturale. Inoltre, questo saggio descrive in che modo il processo collettivo di consumo portato avanti dai Wu Ming contribuisca alla formazione delle «communities of sentiment» di Arjun Appadurai e alla «intelligenza collettiva» di Jenkins. Queste sono formazioni che rivitalizzano il concetto di cultura popolare per la nostra epoca digitale e offrono un’alternativa ad un immaginario culturale italiano sovra-determinato dalle pratiche del Berlusconismo.

  20. Combinatorial interpretation of Haldane-Wu fractional exclusion statistics.

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    Aringazin, A K; Mazhitov, M I

    2002-08-01

    Assuming that the maximal allowed number of identical particles in a state is an integer parameter, q, we derive the statistical weight and analyze the associated equation that defines the statistical distribution. The derived distribution covers Fermi-Dirac and Bose-Einstein ones in the particular cases q=1 and q--> infinity (n(i)/q-->1), respectively. We show that the derived statistical weight provides a natural combinatorial interpretation of Haldane-Wu fractional exclusion statistics, and present exact solutions of the distribution equation.

  1. Kandelia obovata (S., L.) Yong tolerance mechanisms to Cadmium: Subcellular distribution, chemical forms and thiol pools

    International Nuclear Information System (INIS)

    Weng Bosen; Xie Xiangyu; Weiss, Dominik J.; Liu Jingchun; Lu Haoliang; Yan Chongling

    2012-01-01

    Highlights: ► Cadmium tolerance mechanisms of Kandelia obovata was investigated systematacially. ► Thiol pool can play roles in cadmium detoxification mechanisms. ► Increasing cadmium treatment strength caused proportional increase of cadmium uptake. ► More than half of cadmium was localized in cell walls, and lowest in membranes. ► Sodium chloride and acetic acid extractable fractions were dominant. - Abstract: In order to explore the detoxification mechanisms adopted by mangrove under cadmium (Cd) stress, we investigated the subcellular distribution and chemical forms of Cd, in addition to the change of the thiol pools in Kandelia obovata (S., L.) Yong, which were cultivated in sandy culture medium treated with sequential Cd solution. We found that Cd addition caused a proportional increase of Cd in the organs of K. obovata. The investigation of subcellular distribution verified that most of the Cd was localized in the cell wall, and the lowest was in the membrane. Results showed sodium chloride and acetic acid extractable Cd fractions were dominant. The contents of non-protein thiol compounds, Glutathione and phytochelatins in K. obovata were enhanced by the increasing strength of Cd treatment. Therefore, K. obovata can be defined as Cd tolerant plant, which base on cell wall compartmentalization, as well as protein and organic acids combination.

  2. County town -- jian-zhi town differentials and migration to towns in China.

    Science.gov (United States)

    Ma, R

    1993-07-01

    China's urbanization process is unique in having been due to economic systems and migration policies. Towns and townships in rural areas are different from cities in their social and economic characteristics and their structure and function. The urban system in China is initially described with the distinction drawn between cities, "jian-zhi towns", (organic town) which are officially recognized, and rural areas. Analysis is provided f the economic and residential registration status of town residents and migration in northern China. Data were obtained from a 1987 survey of 1314 households in Wongnioute Banner in Inner Mongolia, and a 1985 migration survey of 2089 rural households in 41 villages. The study area was selected because jian-zhi town status was easily obtained and the are needed more towns for local administration and trade; the area was similar in geographic, social, economic, and cultural characteristics to other northern and northwestern regions. The Wongnioute Banner comprises 5 towns (Qiaotou, Wufendi, Hairesu, Wuduentaohai, and Wutonghua) and 1 country town (Wudan). All citizens from birth have an agricultural or nonagricultural status, which can be changed by passing national exams or completing a university education, joining the military and becoming an officer, marrying someone with a nonagricultural status, reunifying the family, or holding a special program. Quotas are set annually for status changes, e.g. in Tibet Autonomous Region the annual quota was 3%. Town residents may have either status. In the sample, 56.6% lived in town and had a nonagricultural status; 17.7% of heads of household town residents had an agricultural status and had stronger ties to villages because of family connections. Commuters are a third group and comprise 8.9%. County towns and jian-zhi towns are grouped the same, but are quite different in population size. Wudan had a population of 27,600 spread over an area of 480 hectares. The jian-zhi towns each had an

  3. Kim Wŏn-haeng’s Intellectual Influences on Hong Tae-yong: The Case of Relations between

    Directory of Open Access Journals (Sweden)

    Login Lok-yin Law

    2015-08-01

    Full Text Available In the 18th century Chosŏn (1392-1910, some scholars, such as Hong Tae-yong (1731-1783 advocated that Chosŏn should learn the advantages of the Qing (1644-1912 society to reform the social structure and government of Chosŏn. The school of these advocates has been known as Pukhak by historians. The intellectual factors of the school of Pukhak’s formation and development have been overlooked by the academia of Chosŏn intellectual history. In fact, Pukhak was closely related to the idea of the school of Nakhak which believed that nature of things was equivalent to humans. Kim Wŏn-haeng, was one of the supporters of Nakhak and Hong Tae-yong was one of the students of Kim. Hong’s thought and writing exposed that his thought was profoundly influenced by Kim Wŏn-haeng. Hong was deemed to be the first prominent scholar of the Pukhak School during the 18th century Chosŏn. Hong and other scholars of Pukhak advocated learning the new knowledge from Qing China even though it was a barbarian society. Therefore, this paper will investigate the intellectual relationships between Hong Tae-yong and Kim Wŏn-haeng to reveal how intellectuals of Nakhak shaped the formation of Pukhak School and exposed the idea of learning from Qing China.

  4. Professor Ta-You Wu and his ideas of science

    International Nuclear Information System (INIS)

    Ye Minghan; Dai Nianzu

    2005-01-01

    The career of Professor Ta-You Wu and his contributions in the latter half of his life in Taiwan, China are briefly reviewed. The authors focus our discussion on some of his ideas in pushing forward the advancement of science and technology in Taiwan and in promoting scientific standards. These ideas include: emphasis on the importance of basic science and qualified personnel as the foundation for the development of science and technology, and while advocating applied science he pointed out that 'future profits depend on high technology'. Thus, he contributed greatly to the rise of the economy in Taiwan. His view of the dispute between Bohr and Einstein is also briefly reviewed, as well as his principles of leadership as the president of Academia Sinica, Taiwan. (author)

  5. Effects of Capsule Yi -Zhi on learning and memory disorder and beta-amyloid peptide induced neurotoxicity in rats

    Institute of Scientific and Technical Information of China (English)

    XUJiang-Ping; WUHang-Yu; LILin

    2004-01-01

    AIM To investigate the effects of Capsule Yi-Zhi (CYZ) on learning and memory disorder and beta-amyloid protein induced neurotoxieity in rats. Methods Various doses of CYZ were administered to Sprague-Dawley (SD) rats for 8 days, twice a day. Then scopolamine hydrobromide (Sco) intraperitoneal injection was performed on each rat and the

  6. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007).

    OpenAIRE

    Alzo David-West

    2013-01-01

    This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses...

  7. Effect of healthy Qigong “WuQinXi” exercise on peripheral blood T ...

    African Journals Online (AJOL)

    USER

    2010-07-19

    Jul 19, 2010 ... cell subgroups in elderly “WuQinXi” practitioners. Fifty healthy Chinese ... on health condition, diet, medical history, lifestyle and menstrual status, .... Mechanism of health-promotion of “WuQinXi” exercise created in East Hai ...

  8. We Can't Get No (Life) Satisfaction? Comment on Oswald and Wu (2010)

    Science.gov (United States)

    Pesta, Bryan J.; McDaniel, Michael A.; Bertsch, Sharon

    2010-01-01

    Oswald and Wu (2010; "Science") recently reported life satisfaction ranks for residents of the 50 U.S. states. Their rankings were framed as measures of "well-being," but were derived from responses to only a single survey item ("In general, how satisfied are you with your life?"). Here we contrast Oswald and Wu's subjective rankings with our…

  9. Governing Civil Service Pay in China, by Alfred M. Wu. Copenhagen: NIAS Press, 2014. xvi+236 pp

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2016-01-01

    Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014.......Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014....

  10. Chien-Shiung Wu: An Icon of Physicist and Woman Scientist in China

    Science.gov (United States)

    Zhu, Yuelin

    2014-03-01

    Chien-Shiung Wu, the first female president of APS, is a well-known figure in China, a figure who serves as an inspiration for youths, especially young women, to study science and particularly physics. In this presentation, a historical perspective will be used to show how such an icon was formed. Born in 1912, the year of the Republic Revolution, Wu was in the first generation of physicists in China and her college mentor was a student of Marie Curie. When Wu came to the U.S. for graduate studies in the 1930s, it was a ``golden age'' for nuclear physics, and the invention of the cyclotron by E. O. Lawrence put UC Berkeley at the frontier. Wu was trained there, with Lawrence as her advisor, and later became an expert in Beta-decay. In 1956, Wu conceived and initiated the experiment of Cobalt-60, which, together with other two experiments, eventually proved the asymmetry of parity in weak-interactions, a hypothesis proposed by T. D. Lee and C. N. Yang. The importance of the experiment gained Wu an enormous reputation which spread even to China, when this was a period of hostility in Sino-American relations, and near total isolation due to the Cold-War. Wu was the daughter of a revolutionary, and an activist in college in patriotic student movements, and she combined this background with her scientific career as the way of ``Saving China with Science,'' a common belief reflecting the Zeitgeist of her time. Although she spent most of her life in the U.S., Wu never wavered in her love for or loyalty to her motherland. Her patriotism, as well as her scientific achievement, made Wu a legend in China, being called ``the Chinese Madam Curie.'' Even during the Cultural Revolution, a novel supposedly taking Wu as the original model was very popular in underground circles, widely spread by hand-written-copies. From 1979-1988, the CUSPEA program enrolled hundreds of China's best graduate students into physics departments in American universities. Although Wu herself was not

  11. Effects of Compound Yi-Zhi on D-galactose-induced learning and memory deficits in mice

    Institute of Scientific and Technical Information of China (English)

    XUJiang-Ping; WUHang-Yu; LILin

    2004-01-01

    AIM: To explore the effects of Compound Yi-Zhi (YZC) on learning and memory capacity and free radical metabolism in D-galactose induced mice dementia model. METHODS: The mice dementia model was induced by a daily D-galactose 0.15g/kg sc for 45 days and after 5 days'D-galactose injection, the mice were treated with three doses of YZC

  12. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007.

    Directory of Open Access Journals (Sweden)

    Alzo David-West

    2013-11-01

    Full Text Available This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses the structural relations of the narrative, its discourse on desire, its apparent intentions, and its contravening elements, revealing an incidental unstable narrative that is symbolically protesting of the moral of the story to affectionately embrace the political authority of the North Korean party-army regime in the military-first (songun era.

  13. Interlopers, Rogues, or Cosmopolitans? Wu Jianzhang and Early Modern Commercial Networks on the China Coast

    Directory of Open Access Journals (Sweden)

    Peter C. Perdue

    2017-12-01

    Full Text Available After the First Opium War (1839–1842, British and American merchants negotiated with Chinese officials in Shanghai to work out the framework of the new treaty port regime. One key player in these negotiations was Wu Jianzhang, a Cantonese merchant who became circuit intendant of the Shanghai region. Wu, however, also had links to Cantonese sailors and anti-Qing secret societies. When the Small Swords Society took Shanghai in 1853, he found himself entangled in conflicting responsibilities and networks. Foreign traders and Chinese officials regarded Wu, like other middlemen on the Chinese coast, with a mixture of respect and distrust. Wu’s situation, however, was not unique to the mid-nineteenth century. This article compares Wu to other intermediaries who played similar roles in the sixteenth and late nineteenth centuries, in order to show the ways in which Wu, his predecessors, and those who followed in his footsteps connected China to the wider world by navigating the treacherous waters of diplomacy, war, and commerce. The work of John K. Fairbank, who in the 1950s pioneered the study of such people as Wu Jianzhang, can find new meaning in the twenty-first century, enabling us to understand the transnational implications of China’s local social history.

  14. Art as a Political Act: Expression of Cultural Identity, Self-Identity, and Gender by Suk Nam Yun and Yong Soon Min

    Science.gov (United States)

    Caruso, Hwa Young Choi

    2005-01-01

    This cross-cultural study explored the lives of two contemporary Korean/Korean American women artists--Suk Nam Yun and Yong Soon Min--who live in Seoul, South Korea, and Los Angeles, California. The author's research focused on the artists' identity formation, artistic expression, professional achievements, and the role of art as a political act.…

  15. Lattice models and integrability: a special issue in honour of F Y Wu

    Science.gov (United States)

    Guttmann, A. J.; Jacobsen, J. L.

    2012-12-01

    Fa Yueh (Fred) Wu was born on 5 January 1932 in Nanking (now known as Nanjing), China, the capital of the Nationalist government. Wu began kindergarten in 1937 in a comfortable setting, as his father held a relatively high government position. But the Sino-Japanese war broke out in July 1937, and Nanking fell to Japanese hands in November. Fleeing the Japanese, his parents brought Wu to their hometown in Hunan, and then to the war capital Chungking (now Chongqing) in 1938, where they lived for eight years until the end of the war. Around that time the Japanese began bombing Chungking, and Wu's childhood memories were dominated by air raids, bombings and burning not dissimilar to those experienced by Londoners during the war. At times the air raids lasted for days disrupting everyday lives in Chungking, including Wu's schooling. One day during a fierce bombing raid, a bomb fell in their garden reducing a pavilion and the surrounding pond to a huge crater; another bomb fell just a few metres from the tunnel where his family took shelter, almost sealing the only entrance. The family moved the very next day to the countryside. As a result of the war, Wu attended seven schools before finishing his primary education. Fortunately, by the time he entered junior high school in 1943, the Japanese forces were on the wane and Wu entered the elite middle school, Nankai. His early academic performance in Nankai seemed to him mediocre, but he nevertheless impressed his geometry teacher by showing bursts of talent. With hindsight, this early interest in geometry may have led to his later insights in graphical analyses of statistical systems. The family returned to Nanking in 1946 after the Victory over Japan Day. By this time his father had become elected to the Legislative Yuan, the equivalent of the US Senate. Wu entered high school in Nanking in 1946. Since he came from an elite school in Chungking, he excelled in most of his classes, especially mathematics. Notwithstanding his

  16. Ray Wu as Fifth Business: Deconstructing collective memory in the history of DNA sequencing.

    Science.gov (United States)

    Onaga, Lisa A

    2014-06-01

    The concept of 'Fifth Business' is used to analyze a minority standpoint and bring serious attention to the role of scientists who play a galvanizing role in a science but for multiple reasons appear less prominently in more common recounts of any particular development. Biochemist Ray Wu (1928-2008) published a DNA sequencing experiment in March 1970 using DNA polymerase catalysis and specific nucleotide labeling, both of which are foundational to general sequencing methods today. The scant mention of Wu's work from textbooks, research articles, and other accounts of DNA sequencing calls into question how scientific collective memory forms. This alternative history seeks to understand why a key figure in nucleic acid sequence analysis has remained less visibly connected or peripheral to solidifying narratives about the history of DNA sequencing. The study resists predictable dismissals of Wu's work in order to seriously examine the formation of his nucleic acid sequence analysis research program and how he shared his knowledge of sequencing during a period of rapid advancement in the field. An analysis of Wu's work on sequencing the cohesive ends of lambda bacteriophage in the 1960s and 1970s exemplifies how a variety of individuals and groups attempted to develop protocol for sequencing the order of nucleotide base pairs comprising DNA. This historical examination of the sociality of scientific research suggests a way to understand how Wu and others contributed to the very collective memory of DNA sequencing that Wu eventually tried to repair. The study of Wu, who was a Chinese immigrant to the United States, provides a foundation for further critical scholarship on the heterogeneous histories of Asian American bioscientists, the sociality of their scientific works, and how the resulting knowledge produced is preserved, if not evenly, in a scientific field's collective memory. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. The Species Identity of the Widely Cultivated Ganoderma, ‘G. lucidum’ (Ling-zhi), in China

    Science.gov (United States)

    Wang, Xin-Cun; Xi, Rui-Jiao; Li, Yi; Wang, Dong-Mei; Yao, Yi-Jian

    2012-01-01

    Ling-zhi, a widely cultivated fungus in China, has a long history in traditional Chinese medicine. Although the name ‘Ganoderma lucidum’, a species originally described from England, has been applied to the fungus, their identities are not the same. This study aims to clarify the identity of this medicinally and economically important fungus. Specimens of Ling-zhi from China (field collections and cultivated basidiomata of the Chinese ‘G. lucidum’), G. lucidum from UK and other related Ganoderma species, were examined both morphologically and molecularly. High variability of basidioma morphology was found in the cultivated specimens of the Chinese ‘G. lucidum’, while some microscopic characters were more or less consistent, i.e. short clavate cutis elements, Bovista-type ligative hyphae and strongly echinulate basidiospores. These characters were also found in the holotype of G. sichuanense, a species originally described from Sichuan, China, and in recent collections made in the type locality of the species, which matched the diagnostic characters in the prologue. For comparison, specimens of closely related species, G. lucidum, G. multipileum, G. resinaceum, G. tropicum and G. weberianum, were also examined. DNA sequences were obtained from field collections, cultivated basidiomata and living strains of the Chinese ‘G. lucidum’, specimens from the type locality of G. sichuanense, and specimens of the closely related species studied. Three-gene combined analyses (ITS+IGS+rpb2) were performed and the results indicated that the Chinese ‘G. lucidum’ shared almost identical sequences with G. sichuanense. Based on both morphological and molecular data, the identity of the Chinese ‘G. lucidum’ (Ling-zhi) is considered conspecific with G. sichuanense. Detailed morphological descriptions and illustrations are provided in addition to discussion of nomenclature implications. PMID:22911713

  18. The Hintermann-Merlini-Baxter-Wu and the infinite-coupling-limit Ashkin-Teller models

    Energy Technology Data Exchange (ETDEWEB)

    Huang Yuan, E-mail: huangy22@mail.ustc.edu.cn [Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Deng Youjin, E-mail: yjdeng@ustc.edu.cn [Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Jacobsen, Jesper Lykke, E-mail: jacobsen@lpt.ens.fr [Laboratoire de Physique Theorique, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Universite Pierre et Marie Curie, 4 place Jussieu, 75252 Paris (France); Salas, Jesus, E-mail: jsalas@math.uc3m.es [Grupo de Modelizacion, Simulacion Numerica y Matematica Industrial, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911 Leganes (Spain); Grupo de Teorias de Campos y Fisica Estadistica, Instituto Gregorio Millan, Universidad Carlos III de Madrid, Unidad asociada al IEM-CSIC, Madrid (Spain)

    2013-03-11

    We show how the Hintermann-Merlini-Baxter-Wu model (which is a generalization of the well-known Baxter-Wu model to a general Eulerian triangulation) can be mapped onto a particular infinite-coupling-limit of the Ashkin-Teller model. We work out some mappings among these models, also including the standard and mixed Ashkin-Teller models. Finally, we compute the phase diagram of the infinite-coupling-limit Ashkin-Teller model on the square, triangular, hexagonal, and kagome lattices.

  19. On the de Rham–Wu decomposition for Riemannian and Lorentzian manifolds

    International Nuclear Information System (INIS)

    Galaev, Anton S

    2014-01-01

    It is explained how to find the de Rham decomposition of a Riemannian manifold and the Wu decomposition of a Lorentzian manifold. For that it is enough to find parallel symmetric bilinear forms on the manifold, and do some linear algebra. This result will allow to compute the connected holonomy group of an arbitrary Riemannian or Lorentzian manifold. (paper)

  20. Rap and Resistance: A Social Movement of the Wu-Tang Clan.

    Science.gov (United States)

    Chasteen, Amy L.; Shriver, Thomas

    1998-01-01

    Examines specific collective identity and political expression of the rap group the Wu-Tang Clan. Reveals a multi-layered political strategy that has been conscientiously designed and implemented to instigate a social movement. Prioritizes the voices of marginalized Black peoples and provides raw narratives about oppression. (MMU)

  1. Analysing the Wu metric on a class of eggs in Cn–II

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 127; Issue 3. Analysing the Wu metric on a class of eggs in C C n – I I .... G P BALAKUMAR1 PRACHI MAHAJAN2. Indian Statistical Institute, Chennai 600 113, India; Department of Mathematics, Indian Institute of Technology – Bombay, Mumbai 400 076, India ...

  2. Analysing the Wu metric on a class of eggs in ℂn – I

    Indian Academy of Sciences (India)

    G P BALAKUMAR

    An explicit description of the Wu metric on the Thullen domains (these are also ..... K(p,v), when p varies across Z. It suffices to focus attention on the case when p varies ... Substituting this into (6.3) and dividing throughout by ˜t2| ˆw|2p2. 1.

  3. Strength-based Supervision: Frameworks, Current Practice, and Future Directions A Wu-wei Method.

    Science.gov (United States)

    Edwards, Jeffrey K.; Chen, Mei-Whei

    1999-01-01

    Discusses a method of counseling supervision similar to the wu-wei practice in Zen and Taoism. Suggests that this strength-based method and an understanding of isomorphy in supervisory relationships are the preferred practice for the supervision of family counselors. States that this model of supervision potentiates the person-of-the-counselor.…

  4. Investigation of the Livengood–Wu integral for modelling autoignition in a high-pressure bomb

    NARCIS (Netherlands)

    Hu, Zhixin; Somers, Bart L.M.T.; Cracknell, Roger F.; Bradley, Derek

    2016-01-01

    The reaction progress variable, which is widely used in premixed and diffusion combustion studies, comprises a set of pre-selected intermediate species to denote reaction progress. Progress towards autoignition can also be traced by the Livengood–Wu (LW) integral. Autoignition occurs when the LW

  5. Anti-RhoC siRNAs inhibit the proliferation and invasiveness of breast cancer cells via modulating the KAI1, MMP9, and CXCR4 expression

    OpenAIRE

    Xu, Xu-Dong; Shen, Han-Bin; Zhu, Li; Lu, Jian-Qin; Zhang, Lin; Luo, Zhi-Yong; Wu, Ya-Qun

    2017-01-01

    Xu-Dong Xu,1 Han-Bin Shen,1 Li Zhu,2 Jian-Qin Lu,2 Lin Zhang,3 Zhi-Yong Luo,3 Ya-Qun Wu3 1Department of Thyroid and Breast Surgery, The Fifth Hospital of Wuhan, Hanyang District, 2Department of Oncology, 3Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China Abstract: Overexpression of RhoC in breast cancer cells indicates poor prognosis. In the present study, we ai...

  6. Mellin-Barnes regularization, Borel summation and the Bender-Wu asymptotics for the anharmonic oscillator

    International Nuclear Information System (INIS)

    Kowalenko, V.; Rawlinson, A.A.

    1998-01-01

    We introduce the numerical technique of Mellin-Barnes regularization, which can be used to evaluate both convergent and divergent series. The technique is shown to be numerically equivalent to the corresponding results obtained by Borel summation. Both techniques are then applied to the Bender-Wu formula, which represents an asymptotic expansion for the energy levels of the anharmonic oscillator. We find that this formula is unable to give accurate values for the ground state energy, particularly when the coupling is greater than 0.1. As a consequence, the inability of the Bender-Wu formula to yield exact values for the energy level of the anharmonic oscillator cannot be attributed to its asymptotic nature. (authors)

  7. The complete mitochondrial genome of a stonefly species, Kamimuria chungnanshana Wu, 1948 (Plecoptera: Perlidae).

    Science.gov (United States)

    Wang, Kai; Ding, Shuangmei; Yang, Ding

    2016-09-01

    This study determined the complete mitochondrial (mt) genome of the stonefly, Kamimuria chungnanshana Wu, 1948. The mt genome is 15, 943 bp in size and contains 37 canonical genes which include 22 transfer RNA genes, 13 protein-coding genes, and two ribosomal RNA genes, the control region is 1062 bp in length. The phylogenetic tree shows that Kamimuria chungnanshana is sister group of Kamimuria wangi.

  8. Madame Wu Chien-Shiung the first lady of physics research

    CERN Document Server

    Chiang, Tsai-Chien

    2014-01-01

    Narrating the well-lived life of the "Chinese Madame Curie" - a recipient of the first Wolf Prize in Physics (1978), the first woman to receive an honorary doctorate from Princeton University, as well as the first female president of the American Physics Society - this book provides a comprehensive and honest account of the life of Dr. Chien-Shiung Wu, an outstanding and leading experimental physicist of the 20th century.

  9. Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine.

    Science.gov (United States)

    Chen, Jianxin; Zhao, Huihui; Yang, Ying; Liu, Bing; Ni, Jian; Wang, Wei

    2011-04-12

    Jiang-Zhi-Ning (JZN) is composed of four Chinese herbs, i.e., Fleeceflower Root, Fructus Crataegi, Folium Nelumbinis and Semen Cassiae. It was used to strengthen blood circulation of coronary artery, arrhythmia and hyperlipidemia. The main objective of this paper is to evaluate lipid-lowering and antioxidant activities of extract and effective fraction of JZN by using in vitro experiments on hyperlipidemic rats. Moreover, in vivo experiments on cells were performed to investigate lipid-lowering and antioxidant activities of effective fraction and active constituents of JZN. Wistar rats with high fat diet-induced hyperlipidemia were used as in vitro models to study biological effects of lipid-lowering and antioxidant activities of extract and effective fraction of JZN. Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Coronary Index and Atherogenic Index were investigated to evaluate lipid-lowering effects of extract and effective fraction of JZN. Serum total nitric oxide synthase (NOS), nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were detected to measure antioxidant effects of extract and effective fraction of JZN. Furthermore, oxidized low-density lipoprotein (Ox-LDL) injured human umbilical vein endothelial cell (HUVEC) model was employed as in vivo experiment to study lipid-lowering and antioxidant effects of effective fraction and active constituents of JZN. NO, ET-1, MDA SOD and T-AOC in HUVECs or culture media were investigated to evaluate antioxidant activity of effective fraction and active constituents of JZN. Using human hepatoma cell line Bel-7402, reverse transcription polymerase chain reaction (RT-PCR) technology was performed to investigate cholesterol metabolism effects of effective fraction and active constituents of JZN. Expressions of low density lipoprotein receptor (LDL

  10. Protection of nucleated bone marrow cells of mice against effect of radiation-induced micronucleus formation by using polysaccharides extracted from 'Zi Zhi' (a ganoderma)

    International Nuclear Information System (INIS)

    Chu Fang; Luo Houliang; Luo Gui; Chen Shunle; Liu Zhifang

    1988-01-01

    This paper describes the influence of polysaccharides extracted from 'Zi Zhi' (Ganoderma Sinese Zhao, Xu et Zhang) on the frequency of micronucleated cells induced by 60 Co gamma irradiation at different doses in bone marrow of mice. These polysaccharides of 'Zi Zhi' were shown to be of ability to protect nucleated bone marrow cells from micronucleus formation in irradiated mice. For Swiss mice, a dose reduction factor (DRF) was found to be 1.72 in the range of 0 to 4.728 Gy and for LACA mice, to be 1.73 in the range of 0 to 3.152 Gy. Such findings indicate that these polysaccharides are comparable to L-cysteine in their effeciency of protection

  11. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    OpenAIRE

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial...

  12. The Anti-Inflammatory Effects of a Yin Zhi Huang Soup in an Experimental Autoimmune Prostatitis Rat Model

    Directory of Open Access Journals (Sweden)

    Longsheng Deng

    2017-01-01

    Full Text Available The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS in an experimental autoimmune prostatitis (EAP rat model. In total, 48 rats were randomly divided into the following four groups (n=12/group: saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor-alpha (TNF-α levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS in the rats’ prostate tissues, and the pathological changes in the prostate tissue using light microscopy. YZS reduced the rats’ prostate wet weight, the ratio of the prostate wet weight to body weight, and TNF-α levels in the blood serum and inhibited the expression of iNOS in the rats’ prostate tissues (P<0.05. Following YZS treatment, the pathological changes in the rats’ prostates were improved compared with those in the model group (P<0.05. Furthermore, YZS treatment reduced inflammatory changes in the prostate tissue. It also significantly suppressed proinflammatory cytokines, such as TNF-α, and chemokines, such as iNOS, in the rat model of EAP.

  13. Identification of the Chemical Constituents in Aqueous Extract of Zhi-Qiao and Evaluation of Its Antidepressant Effect

    Directory of Open Access Journals (Sweden)

    Ming Wu

    2015-04-01

    Full Text Available The immature fruit of Citrus aurantium L. (Zhi-Qiao, ZQ has been used as a traditional medicine in China. Our previous study has shown that ZQ decoction may contribute to the antidepressant-like action of Chaihu-Shu-Gan-San. However, there are no reports on the chemical constituents of ZQ aqueous extract or its anti-depression effects. Firstly, this research reported the on-line identification of the chemical constituents in the aqueous extract of ZQ by coupling ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC-Q-TOF/MS. A total of 31 chemical constituents were identified in ZQ aqueous extract, including one tannic acid, five flavones, 13 flavanones, one limonoid, three coumarins, three cyclic peptides, and five polymethoxylated flavonoids. The antidepressant effect of ZQ aqueous extract was evaluated in vivo and the results indicated that the mice immobility time during the forced swimming test and the tail suspension test were significantly reduced with ZQ treatment. MTT assays showed both ZQ aqueous extract and its major constituents (naringin, hesperidin, neohesperidin, and nobiletin had neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells. The in vivo and in vitro results suggest that ZQ has an antidepressant effect.

  14. Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials

    Directory of Open Access Journals (Sweden)

    Ningchang Cheng

    2017-01-01

    Full Text Available Introduction. Zhi Sou San (ZSS, a traditional Chinese prescription, has been widely applied in treating cough. The purpose of this meta-analysis was to evaluate the effectiveness and safety of ZSS for cough. Methods. We searched relevant articles up to 5 March 2017 in seven electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL, MEDLINE, PubMed, Chinese National Knowledge Infrastructure (CNKI, Cqvip Database (VIP, China Biology Medicine disc (CBM, and Wanfang Data. Randomized controlled trials (RCTs were eligible, regardless of blinding. The primary outcome was the total effective rate. Results. Forty-six RCTs with a total of 4007 participants were identified. Compared with western medicine, ZSS significantly improved the total effective rate (OR: 4.45; 95% CI: 3.62–5.47 and the pulmonary function in terms of FEV1 (OR: 0.35; 95% CI: 0.24–0.46 and decreased the adverse reactions (OR: 0.05; 95% CI: 0.02–0.01 and the recurrence rate (OR: 0.30; 95% CI: 0.16–0.57. However, there was no significant improvement in the cough symptom score comparing ZSS with western medicine. Conclusions. This meta-analysis shows that ZSS has significant additional benefits and relative safety in treating cough. However, more rigorously designed investigations and studies, with large sample sizes, are needed because of the methodological flaws and low quality of the included trials in this meta-analysis.

  15. Phylogeography of Sophora moorcroftiana Supports Wu's Hypothesis on the Origin of Tibetan Alpine Flora.

    Science.gov (United States)

    Cheng, Shanmei; Qiong, La; Lu, Fan; Yonezawa, Takahiro; Yin, Ganqiang; Song, Zhiping; Wang, Yuguo; Yang, Ji; Zhang, Wenju

    2017-06-01

    Wu hypothesized that the Tibetan flora originated mostly from the paleotropical Tertiary flora in the Hengduan Mountains by adapting to the cold and arid environments associated with the strong uplift of the Qinghai-Tibet Plateau (QTP). Here, we combine the phylogeographic history of Sophora moorcroftiana with that of Sophora davidii to explore the speciation of S. moorcroftiana to test this hypothesis. We collected 151 individuals from 17 populations and sequenced 2 chloroplast fragments and the internal transcribed spacer of rDNA. Five chlorotypes and 9 ribotypes were detected but no significant phylogeographic structure was revealed. The integrated results of phylogeographic studies of these 2 species clearly support the progenitor-derivative relationship between them. We infer that the western peripheral population of S. davidii migrated westwards from the Hengduan Mountains to the middle reaches of the Yarlung Zangbo River and differentiated from its ancestor in the process of adaptation to increasingly cold and arid environments with the uplift of the QTP and finally evolved into S. moorcroftiana during the Late Pliocene. In addition, our findings shed light on the idea that natural selection, as imposed by climate differentiation (especially mean diurnal range and precipitation seasonality), directly drove this peripatric speciation event after geographic isolation. The speciation of S. moorcroftiana is a strong case supporting Wu's hypothesis about the origin of Tibet's flora. © The American Genetic Association 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Effects of electroacupuncture and electroacupuncture plus Tao Hong Si Wu Wan in treating primary dysmenorrhea.

    Science.gov (United States)

    Miao, Edwin Yong; Miao, Miranda Yi-mo; Kildea, Daniel George; Lao, Yi-Wen

    2014-02-01

    This study investigated the efficacies of electroacupuncture and electroacupuncture combined with Tao Hong Si Wu Wan in treating primary dysmenorrhea and compared the results with those obtained using conventional medical treatment. One treatment group, group 1, was administered Tao Hong Si Wu Wan (2625 mg) while the other, group 2, was administered a placebo (2625 mg) twice daily for 3 months. Electroacupuncture was used in both treatment groups: two sessions per menstrual cycle for three menstrual cycles. The reference group, group 3, was administered ibuprofen, 600 mg, twice daily, for five menstrual cycles. Uses of the herb, placebo and ibuprofen were blinded. A ridit analysis was used for testing and interpreting the effects of treatment. Pain intensity was determined using a qualitative grading method in a blinded manner. The ridit scores in groups 1 and 2 were significantly higher than those in reference group immediately after treatment and three months later. Twelve months after the treatment, group 1 had a higher ridit score than group 2. In comparison to the reference group, groups 1 and 2 achieved better menstrual pain relief both immediately and 3 months after treatment. In addition, group 1 had better long-term pain relief than group 2. Copyright © 2014. Published by Elsevier B.V.

  17. Ignition delay time correlation of fuel blends based on Livengood-Wu description

    KAUST Repository

    Khaled, Fathi

    2017-08-17

    In this work, a universal methodology for ignition delay time (IDT) correlation of multicomponent fuel mixtures is reported. The method is applicable over wide ranges of temperatures, pressures, and equivalence ratios. n-Heptane, iso-octane, toluene, ethanol and their blends are investigated in this study because of their relevance to gasoline surrogate formulation. The proposed methodology combines benefits from the Livengood-Wu integral, the cool flame characteristics and the Arrhenius behavior of the high-temperature ignition delay time to suggest a simple and comprehensive formulation for correlating the ignition delay times of pure components and blends. The IDTs of fuel blends usually have complex dependences on temperature, pressure, equivalence ratio and composition of the blend. The Livengood-Wu integral is applied here to relate the NTC region and the cool flame phenomenon. The integral is further extended to obtain a relation between the IDTs of fuel blends and pure components. Ignition delay times calculated using the proposed methodology are in excellent agreement with those simulated using a detailed chemical kinetic model for n-heptane, iso-octane, toluene, ethanol and blends of these components. Finally, very good agreement is also observed for combustion phasing in homogeneous charge compression ignition (HCCI) predictions between simulations performed with detailed chemistry and calculations using the developed ignition delay correlation.

  18. [Research on Japanese monograph of comprehensive dietetic materia medica, the Pao chu bei yong wo ming ben cao (Japanese Materia Medica Prepared for Kitchen)].

    Science.gov (United States)

    Zhou, M; Ye, J

    2017-11-28

    Japanese physicians of Edo Period (1603-1867) wrote many dietetic books, by combining the knowledge system (content and compiling style) and thoughts of diet therapy from China with local condition in Japan. Among them, the Pao chu bei yong wo ming ben cao ( Japanese Materia Medica Prepared for Kitchen ), written by Mukai Genshou, a physician in the early Edo, is the earliest comprehensive work of dietetic materia medica. In this book, the choice and usage of Japanese dietetic materia medica reveals obvious Japanese local color, including the name, morphology, cultivation, collection, identification, nature and flavor, and indication etc., reflecting the sprouting idea of edible herbal plant at the beginning of Edo period and the characteristic of absorbing Chinese diet thoughts by Japanese physician. This is the important first-hand historical material to understand the development of Japanese dietetic herbalism in early Edo and its dietotherapy culture.

  19. Therapeutic effects of FuZhiSan on Alzheimer's disease rat model:evaluation with PET imaging

    International Nuclear Information System (INIS)

    Guo Zhe; Zhang Jinming; Yao Shulin; Feng Huiru; Li Xuling; Yin Dayi; Tian Jiahe

    2010-01-01

    Objective: To assess the feasibility of using PET molecular imaging to evaluate the therapeutic effects of traditional Chinese medicine FuZhiSan (FZS) on the model of aging Alzheimer's disease (AD) rats. Methods: Twenty aged AD rats (Sparague-Dawley rats,male) were randomly divided into FZS treated group (n = 10) and control group (n = 10). Another 10 healthy adult rats were as blank controls. Morris water maze record system was used for cognitive function assessment. Before and after FZS treatment 18 F-fluorodeoxyglucose (FDG) and 11 C-2- [4'-(methylamino) phenyl] benzothiazol-6-ol (PIB) PET imaging was undertaken. After post-treatment imaging procedures the brain tissues of all animals were taken for histochemical study, such as staining with HE, congo red, amyloid β (Aβ) immunofluorescence, 5-bromo-2-deoxyuridine (BrdU) immunofluorescence and NeuN immunofluorescence. Paired t-test was performed with SPSS 13.0 software for the data analysis. Results: The cognitive dysfunction of aging AD rats was improved after FZS treatment. The escape latency in FZS treated group was significantly shorter than that of control group ((32.5 ±10.8) s vs (102.6±8.8) s, t =15.7987, P=0. 0001). Diffuse neuronal loss and Aβ deposition were detected in the hippocampus and cortex in the aged AD rats. The imaging data showed that brain glucose metabolism was amended in FZS treated group while the abatement of amyloid deposition was not significant. Immunofluorescence results indicated that the neuronal proliferation was more remarkable in FZS treated group. Conclusions: It may be feasible to use PET imaging as a method to evaluate the therapeutic effect in AD rats. FZS may ameliorate memory dysfunction of aged AD rats. Its mechanism may be partly contributed to the enhancement of the neuronal proliferation and survival. (authors)

  20. Orbinia wui, a new species from China, with redescription of O. dicrochaeta Wu, 1962 (Annelida, Orbiniidae).

    Science.gov (United States)

    Sun, Yue; Li, Xinzheng

    2018-04-04

    Two species of the genus Orbinia Quatrefages, 1865 are described including Orbinia dicrochaeta Wu, 1962 and Orbinia wui sp. n. The new species can easily be identified from other species in the genus by a combination of characters: branchiae first present from chaetiger 5, thoracic region with 14-16 chaetigers; first six thoracic neuropodia with 4-5 rows of uncini, with the last row short and curving ventral to anterior rows; subsequent thoracic neuropodia with four rows of subuluncini and one short row of uncini, arranged more densely than anterior chaetigers; both uncini and subuluncini surrounded by long sheath all of its length on concave side, sheath with developed transverse rows of barbs. This study suggests that the species of Orbinia may be divided into two groups. A taxonomic key and comparative table to all species of Orbinia is provided.

  1. Prof. Wu Xiaoqiu:China Is Striving for the World's Most Developed Capital Market

    Institute of Scientific and Technical Information of China (English)

    Sun Yongjian; Zhang Yue

    2007-01-01

    @@ China's capital market is a hot issue in the new year. The best strategy to develop the Chinese capital market in the coming 15 to 20 years was discussed in the China Capital Market Forum, which was held in China at Renmin University on January 13. Government officials, scholars, and entrepreneurs commented that by 2020, the Chinese capital market will develop into one of the best capital markets in the world,not only in terms of size, but also asset quality, liquidity and dynamic trade. Is this a realistic goal? What steps should we take to pursue this target? With these questions in mind, after the forum, China's Foreign Trade interviewed Prof. Wu Xiaoqiu, Vice President of Renmin University of China,and the Director of the Finance & Securities Institute of Renmin University.

  2. Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment.

    Science.gov (United States)

    Qin, Hong-Qiong; Shi, Shan-Shan; Fu, Ying-Jie; Yan, Yu-Qi; Wu, Sha; Tang, Xiao-Long; Chen, Xiao-Yin; Hou, Guang-Hui; Jiang, Zhen-You

    2018-01-01

    We wished to investigate the effects of the traditional Chinese medicine Gui Zhi Ma Huang Ge Ban Tang on controlling influenza A virus (IAV) infection and improving inflammation in mouse lungs. Mice were maintained in normal and cold environments and infected with IAV by intranasal application, respectively. Real-time quantitative polymerase chain reaction was used to measure mRNA expression of TLR7, myeloid differentiation primary response 88 (MyD88), and nuclear factor-kappa B (NF- κ B)p65 in the TLR7 signaling pathway and virus replication in lungs. Western blotting was used to measure expression levels of TLR7, MyD88, and NF- κ B p65 proteins. Flow cytometry was used to detect the proportion of T-helper (Th)1/Th2 and Th17/T-regulatory (Treg) cells. Application of Gui Zhi Ma Huang Ge Ban Tang in influenza-infected mice in a cold environment showed (i) downregulation of TLR7, MyD88, and NF- κ Bp65; (ii) inhibition of transcriptional activities of promoters coding for TLR7, MyD88, and NF- κ Bp65; (iii) reduction in the proportion of Th1/Th2 and Th17/Treg cells. Gui Zhi Ma Huang Ge Ban Tang had a good therapeutic effect on mice infected with IAV, especially in the cold environment. It could reduce lung inflammation in mice significantly and elicit an anti-influenza effect by downregulating expression of the key factors in TLR7 signaling pathway.

  3. A Response to Professor Wu Zongjie's "Interpretation, Autonomy, and Transformation: Chinese Pedagogic Discourse in a Cross-Cultural Perspective"

    Science.gov (United States)

    Curran, Thomas D.

    2014-01-01

    In response to an essay by Prof Wu Zongjie that was published in the "Journal of Curriculum Studies" [43(5), (2011), 569-590], I argue that, despite dramatic changes that have taken place in the language of Chinese academic discourse and pedagogy, evidence derived from the fields of psychology and the history of Chinese educational…

  4. 31 july 2014 - H. WU Ambassador Permanent Representative of the People's Republic of China to the United Nations

    CERN Multimedia

    Egli, Laurent

    2014-01-01

    His Excellency Mr Hailong WU Ambassador Permanent Representative of the People's Republic of China to the United Nations Office at Geneva and other international organizations in Switzerland visiting the ATLAS cavern with ATLAS Spokesperson D. Charlton and the LHC tunnel at Point 1 with Technology Department, Vacuum, Surfaces and Coatings Group P. Cruikshank.

  5. Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"

    Science.gov (United States)

    Tan, Sor-Hoon

    2011-01-01

    This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it…

  6. From State-controlled to Polycentric Governance in Forest Landscape Restoration: The Case of the Ecological Forest Purchase Program in Yong'an Municipality of China.

    Science.gov (United States)

    Long, Hexing; Liu, Jinlong; Tu, Chengyue; Fu, Yimin

    2018-07-01

    Forest landscape restoration is emerging as an effective approach to restore degraded forests for the provision of ecosystem services and to minimize trade-offs between conservation and rural livelihoods. Policy and institutional innovations in China illustrate the governance transformation of forest landscape restoration from state-controlled to polycentric governance. Based on a case study of the Ecological Forest Purchase Program in Yong'an municipality, China's Fujian Province, this paper explores how such forest governance transformation has evolved and how it has shaped the outcomes of forest landscape restoration in terms of multi-dimensionality and actor configurations. Our analysis indicates that accommodating the participation of multiple actors and market-based instruments facilitate a smoother transition from state-centered to polycentric governance in forest landscape restoration. Governance transitions for forest landscape restoration must overcome a number of challenges including ensurance of a formal participation forum, fair participation, and a sustainable legislative and financial system to enhance long-term effectiveness.

  7. Dark energy fingerprints in the nonminimal Wu-Yang wormhole structure

    Science.gov (United States)

    Balakin, Alexander B.; Zayats, Alexei E.

    2014-08-01

    We discuss new exact solutions to nonminimally extended Einstein-Yang-Mills equations describing spherically symmetric static wormholes supported by the gauge field of the Wu-Yang type in a dark energy environment. We focus on the analysis of three types of exact solutions to the gravitational field equations. Solutions of the first type relate to the model, in which the dark energy is anisotropic; i.e., the radial and tangential pressures do not coincide. Solutions of the second type correspond to the isotropic pressure tensor; in particular, we discuss the exact solution, for which the dark energy is characterized by the equation of state for a string gas. Solutions of the third type describe the dark energy model with constant pressure and energy density. For the solutions of the third type, we consider in detail the problem of horizons and find constraints for the parameters of nonminimal coupling and for the constitutive parameters of the dark energy equation of state, which guarantee that the nonminimal wormholes are traversable.

  8. Monte Carlo study of the pure and dilute Baxter-Wu model

    International Nuclear Information System (INIS)

    Schreiber, Nir; Adler, Joan

    2005-01-01

    We studied the pure and dilute Baxter-Wu (BW) models using the Wang-Landau (WL) sampling method to calculate the density-of-states (DOS). We first used the exact result for the DOS of the Ising model to test our code. Then we calculated the DOS of the dilute Ising model to obtain a phase diagram, in good agreement with previous studies. We calculated the energy distribution, together with its first, second and fourth moments, to give the specific heat and the energy fourth order cumulant, better known as the Binder parameter, for the pure BW model. For small samples, the energy distribution displayed a doubly peaked shape, and finite size scaling analysis showed the expected reciprocal scaling of the positions of the peaks with L. The energy distribution yielded the expected BW α = 2/3 critical exponent for the specific heat. The Binder parameter minimum appeared to scale with lattice size L with an exponent θ B equal to the specific heat exponent. Its location (temperature) showed a large correction-to-scaling term θ 1 = 0.248 ± 0.025. For the dilute BW model we found a clear crossover to a single peak in the energy distribution even for small sizes and the expected α = 0 was recovered

  9. A new species of Nemoura (Plecoptera: Nemouridae) from Jiangsu Province, China, with new illustrations for Nemoura nankinensis Wu.

    Science.gov (United States)

    Chen, Zhi-Teng; DU, Yu-Zhou

    2017-04-12

    A new species of Nemoura (Plecoptera: Nemouridae), N. fusiformis sp. nov. from Jiangsu Province, China, is described and illustrated. The new species is characterized by a strongly sclerotized large hook formed by outer margin of the outer lobe of the paraproct and by the outer sclerite of cercus with a sub-triangular medial process. The new species is compared with similar taxa. Additionally, supplementary illustrations for N. nankinensis Wu, 1926 are also provided.

  10. PLE-wu, a new member of piggyBac transposon family from insect, is active in mammalian cells.

    Science.gov (United States)

    Wu, Chunxiao; Wang, Shu

    2014-10-01

    piggyBac, a highly active transposon in insect and mammalian cells, is a very useful tool in genome manipulation. A new piggyBac-like element (PLE), named PLE-wu, was identified from a mutant baculovirus cultured in sf9 insect cells. This new transposon is 2931 bp in length and encodes two active forms of transposase, a 708-amino acid-long transposase and a short 576-residue-long transposase translated from a downstream in-frame initiation codon. PLE-wu has asymmetric terminal structures, containing 6-bp inverted terminal repeats, 32-bp imperfect inverted and direct sub-terminal repeats. Similar to piggyBac, PLE-wu exhibits traceless excision activity in both insect and mammalian cells, restoring the original TTAA target sequence upon excision. It also retains the insertion activity in mammalian cells with a plasmid to chromosome transposition rate about 10-fold higher than random integration. Plasmid rescue assays revealed that the TTAA target sequence was duplicated at the junctions of the insertion site. Deletion of the terminal sequences including the sub-terminal repeats decreased the transposition activity of the 708-residue-long transposase, while the transposition activity of the short form of transposase was not affected. With its low sequence similarity to piggyBac, PLE-wu will contribute to the understanding the mechanism of PLE transposition, as well as design of new transposon systems with higher activity. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  11. The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

    Science.gov (United States)

    Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

    2010-09-01

    We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

  12. FORTRAN Code for Glandular Dose Calculation in Mammography Using Sobol-Wu Parameters

    Directory of Open Access Journals (Sweden)

    Mowlavi A A

    2007-07-01

    Full Text Available Background: Accurate computation of the radiation dose to the breast is essential to mammography. Various the thicknesses of breast, the composition of the breast tissue and other variables affect the optimal breast dose. Furthermore, the glandular fraction, which refers to the composition of the breasts, as partitioned between radiation-sensitive glandular tissue and the adipose tissue, also has an effect on this calculation. Fatty or fibrous breasts would have a lower value for the glandular fraction than dense breasts. Breast tissue composed of half glandular and half adipose tissue would have a glandular fraction in between that of fatty and dense breasts. Therefore, the use of a computational code for average glandular dose calculation in mammography is a more effective means of estimating the dose of radiation, and is accurate and fast. Methods: In the present work, the Sobol-Wu beam quality parameters are used to write a FORTRAN code for glandular dose calculation in molybdenum anode-molybdenum filter (Mo-Mo, molybdenum anode-rhodium filter (Mo-Rh and rhodium anode-rhodium filter (Rh-Rh target-filter combinations in mammograms. The input parameters of code are: tube voltage in kV, half-value layer (HVL of the incident x-ray spectrum in mm, breast thickness in cm (d, and glandular tissue fraction (g. Results: The average glandular dose (AGD variation against the voltage of the mammogram X-ray tube for d = 4 cm, HVL = 0.34 mm Al and g=0.5 for the three filter-target combinations, as well as its variation against the glandular fraction of breast tissue for kV=25, HVL=0.34, and d=4 cm has been calculated. The results related to the average glandular absorbed dose variation against HVL for kV = 28, d=4 cm and g= 0.6 are also presented. The results of this code are in good agreement with those previously reported in the literature. Conclusion: The code developed in this study calculates the glandular dose quickly, and it is complete and

  13. Information Philosophy in China: Professor Wu Kun’s 30 Years of Academic Thinking in Information Philosophy

    Directory of Open Access Journals (Sweden)

    Guowu Li

    2011-10-01

    Full Text Available Professor Wu Kun, from Xi'an Jiaotong University of China, has been studying information philosophy for 30 years. He thinks information conception is one of the most fundamental areas in philosophy and has founded information philosophy. He has done original and pioneering research in information ontology, epistemology, social information theory, information production theory, information evolution theory, information value, and information thinking directions. He is the first scholar to develop a completely new view of theories, systems, and methods about information philosophy.

  14. His Excellency Mr Ken WU Ambassador Extraordinary and Plenipotentiary of the People’s Republic of China to Switzerland

    CERN Multimedia

    Jean Claude Gadmer

    2011-01-01

    Photo 1-5:The delegation visiting the ATLAS visitor Center with P.Jenni, ATLAS Collaboration former Spokesperson Photo 6-14,15-20:visiting the ATLAS experimental area Photo 15:Y. YANG,Attaché-Q. WAN,First Secretary-Z. Ren,ATLAS Collaboration,High Energy Group,Shandong University-H.E. Mr K. Wu-P. Jenni-R. Voss,Adviser for the People’s Republic of China-H. FENG,Counsellor Photo 21-38:Signature of the Guest Book with CERN Director-General R. Heuer

  15. [Professor WU Zhongchao's experience in the treatment of bi syndrome with fire needling therapy at lower he-sea points].

    Science.gov (United States)

    Zhou, Yu; Chen, Zhongjie; Liu, Chun; Wang, Bing; Zhang, Ning; Li, Caifen; Xie, Qian

    2016-07-12

    Bi syndrome is classified into five categories. Based on the syndrome differentiation of meridians and collaterals and zangfu theories, Professor WU Zhongchao proposed the fire needling therapy at the lower he -sea points for five types of bi syndromes. Professor WU stresses on the flexible application of fire needling therapy for bi syndrome at the lower he -sea points and innovated the unique five techniques of fire needling therapy, named lifting and threating needle of small amplitude at the lower he -sea points, the stimulation along the relevant meri-dians before fire needling, detecting the sensitive sites by gentle pressing the relevant lower he -sea points, combining the movement of affected upper limb or joint during fire needling, or combining with contralateral needling technique, and controlling the depth of fire needling based on the duration of sickness and depth of affected site. He pointed out that Shangjuxu (ST 37) is for skin bi syndrome, Zusanli (ST 36) for muscle bi syndrome, Yanglingquan (GB 34) for tendon bi syndrome, Weizhong (BL 40) for bone bi syndrome and Xiajuxu (ST 39) for vessel bi syndrome.

  16. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Science.gov (United States)

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety. PMID:25793006

  17. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Lin-lin Hu

    2015-01-01

    Full Text Available Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT and Zhi Zi Chi Tang (ZZCT; SZR-ZZC for improving sleep quality and anxiety states with four indices of Polysomnography (PSG, the Insomnia Severity Index (ISI, the Pittsburgh Sleep Quality Index (PSQI, and the Self Rating Anxiety Scale (SAS. Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n=60 and the lorazepam tablet treatment group (n=59. Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P=0.029, the PSQI (P=0.017, and wake after sleep onset (WASO; P=0.008 scores and improved sleep architecture (P=0.000–0.003 after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

  18. Effect of “Jian-Pi-Zhi-Dong Decoction” on Gamma-Aminobutyric Acid in a Mouse Model of Tourette Syndrome

    Directory of Open Access Journals (Sweden)

    Wen Zhang

    2014-01-01

    Full Text Available The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD on Tourette syndrome (TS by investigating the expression of gamma-aminobutyric acid (GABA and its type A receptor (GABAAR in the striatum of a TS mice model. The model was induced by 3,3′-iminodipropionitrile (IDPN treatment; then mice were divided into 4 groups (n=22, each; control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.

  19. Bian Zheng Lun Zhi as a Complementary and Alternative Treatment for Menstrual Cramps in Women with Dysmenorrhea: A Prospective Clinical Observation

    Directory of Open Access Journals (Sweden)

    Pin-Yi Lin

    2014-01-01

    Full Text Available Background. Limited scientific evidence supports the positive effects of traditional Chinese medicine (TCM for treating dysmenorrhea. Thus, an observation period of 3 months could verify the ancient indication that TCM treatments effectively alleviate menstrual cramps in women with primary dysmenorrhea or endometriosis. Methods. A prospective, nonrandomized study (primary dysmenorrhea and endometriosis groups was conducted in women with dysmenorrhea for more than three consecutive menstrual cycles. All patients received TCM prescriptions based on bian zheng lun zhi theory 14 days before menstruation for a period of 12 weeks. Pain intensity was evaluated using a 10-cm visual analogue scale and two validated questionnaires (the Menstrual Distress Questionnaire and the World Health Organization Quality of Life questionnaire. Results. Of the initial 70 intent-to-treat participants, the women with dysmenorrhea reported significant alleviation of cramps during menstruation after the 12-week TCM treatment. Mixed model analysis revealed that TCM prescriptions were more effective in alleviating fatigue, hot flashes, dizziness, painful breasts, excitement, and irritability in the primary dysmenorrhea group (N=36 than in the endometriosis group (N=34. Conclusion. TCM prescriptions based on syndrome differentiation theory might be a potentially viable choice for treating painful menstruation and premenstrual symptoms after ruling out endometriosis.

  20. Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

    Directory of Open Access Journals (Sweden)

    Jinqiu Yin

    2017-11-01

    Full Text Available As a leading cause of respiratory disease, influenza A virus (IAV presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH is a famous traditional Chinese medicine (TCM used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2 (Nrf2 and nuclear factor kappa B (NF-κB, which subsequently upregulated heme oxygenase-1 (HO-1 expression. Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions, CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway.

  1. Biodesulfurization of Naphthothiophene and Benzothiophene through Selective Cleavage of Carbon-Sulfur Bonds by Rhodococcus sp. Strain WU-K2R

    Science.gov (United States)

    Kirimura, Kohtaro; Furuya, Toshiki; Sato, Rika; Ishii, Yoshitaka; Kino, Kuniki; Usami, Shoji

    2002-01-01

    Naphtho[2,1-b]thiophene (NTH) is an asymmetric structural isomer of dibenzothiophene (DBT), and in addition to DBT derivatives, NTH derivatives can also be detected in diesel oil following hydrodesulfurization treatment. Rhodococcus sp. strain WU-K2R was newly isolated from soil for its ability to grow in a medium with NTH as the sole source of sulfur, and growing cells of WU-K2R degraded 0.27 mM NTH within 7 days. WU-K2R could also grow in the medium with NTH sulfone, benzothiophene (BTH), 3-methyl-BTH, or 5-methyl-BTH as the sole source of sulfur but could not utilize DBT, DBT sulfone, or 4,6-dimethyl-DBT. On the other hand, WU-K2R did not utilize NTH or BTH as the sole source of carbon. By gas chromatography-mass spectrometry analysis, desulfurized NTH metabolites were identified as NTH sulfone, 2′-hydroxynaphthylethene, and naphtho[2,1-b]furan. Moreover, since desulfurized BTH metabolites were identified as BTH sulfone, benzo[c][1,2]oxathiin S-oxide, benzo[c][1,2]oxathiin S,S-dioxide, o-hydroxystyrene, 2-(2′-hydroxyphenyl)ethan-1-al, and benzofuran, it was concluded that WU-K2R desulfurized NTH and BTH through the sulfur-specific degradation pathways with the selective cleavage of carbon-sulfur bonds. Therefore, Rhodococcus sp. strain WU-K2R, which could preferentially desulfurize asymmetric heterocyclic sulfur compounds such as NTH and BTH through the sulfur-specific degradation pathways, is a unique desulfurizing biocatalyst showing properties different from those of DBT-desulfurizing bacteria. PMID:12147483

  2. Accumulation of Arsenic Speciation and In Vivo Toxicity Following Oral Administration of a Chinese Patent Medicine Xiao-Er-Zhi-Bao-Wan in Rats

    Directory of Open Access Journals (Sweden)

    Jiaoyang Luo

    2017-07-01

    Full Text Available Realgar-containing traditional Chinese medicines such as Xiao-Er-Zhi-Bao-Wan (XEZBW, have been widely used for thousands of years. However, events associated with arsenic-induced ailments have increasingly become a public concern. To address the toxicity of XEZBW, we studied the histopathology and blood biochemistry of rats exposed to XEZBW using technology like high-performance liquid chromatography-inductively coupled mass spectrometry to determine arsenic speciation. Our results demonstrated that dimethylarsinic acid (DMA increased from 18.57 ± 7.45 to 22.74 ± 7.45 ng/g in rat kidney after oral administration for 7 and 14 days, which was 10-fold higher than the levels observed in controls. Trivalent arsenite As(III showed a large increase on day 7 (26.99 ± 1.98 ng/g, followed by a slight decrease on day 14 (13.67 ± 6.48 ng/g. Total arsenic levels on day 7 (185.52 ± 24.56 ng/g and day 14 (198.57 ± 26.26 ng/g were nearly twofold higher than that in the control group (92.77 ± 14.98 ng/g. Histopathological analysis showed mild injury in the liver and kidney of rats subjected to oral administration of realgar for 14 days. As in the XEZBW groups, a mild injury in these organs was observed after administration for 14 days. This study inferred that the toxicity of arsenic was concentration- and time-dependent. The accumulation of DMA, a byproduct of choline metabolism, was responsible for inducing higher toxicity. Therefore, we concluded that measuring the levels of DMA, instead of total arsenic, might be more suitable for evaluating the toxicity of realgar-containing traditional Chinese medicines.

  3. Analysis of the Constituents in “Zhu She Yong Xue Shuan Tong” by Ultra High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Preparative High Performance Liquid Chromatography

    Directory of Open Access Journals (Sweden)

    Lin-Lin Wang

    2015-11-01

    Full Text Available “Zhu She Yong Xue Shuan Tong” lyophilized powder (ZSYXST, consists of a series of saponins extracted from Panax notoginseng, which has been widely used in China for the treatment of strokes. In this study, an ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS combined with preparative high performance liquid chromatography (PHPLC method was developed to rapidly identify both major and minor saponins in ZSYXST. Some high content components were removed through PHPLC in order to increase the sensitivity of the trace saponins. Then, specific characteristic fragment ions in both positive and negative mode were utilized to determine the types of aglycone, saccharide, as well as the saccharide chain linkages. As a result, 94 saponins, including 20 pairs of isomers and ten new compounds, which could represent higher than 98% components in ZSYXST, were identified or tentatively identified in commercial ZSYXST samples.

  4. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

    Science.gov (United States)

    Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

    2010-01-15

    Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae.

  5. I Know You Are, But What Am I? : Anti-Individualism in the Development of Intellectual Humility and Wu-Wei

    NARCIS (Netherlands)

    Robinson, Brian; Alfano, M.R.

    2016-01-01

    Virtues are acquirable, so if intellectual humility is a virtue, it’s acquirable. But there is something deeply problematic—perhaps even paradoxical—about aiming to be intellectually humble. Drawing on Edward Slingerland’s analysis of the paradoxical virtue of wu-wei in Trying Not To Try, we argue

  6. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2015-01-01

    Full Text Available Wu-tou decoction (WTD is a classic traditional Chinese medicine formula and has been used effectively to treat joint diseases clinically. Previous reports indicated that WTD possesses anti-inflammatory activity; however, its actions on pain have not been clarified. Here, we investigated the antinociceptive activity of WTD in CFA-induced mice, and its possible mechanism of the action associated with transient receptor potential (TRP ion channels was also explored. Our results showed that 1.58, 3.15, and 6.30 g/kg WTD significantly attenuated mechanical, cold, and heat hypersensitivities. Moreover, WTD effectively inhibited spontaneous nociceptive responses to intraplantar injections of capsaicin and cinnamaldehyde, respectively. WTD also effectively suppressed jumping and wet-dog-shake behaviors to intraperitoneal injection of icilin. Additionally, WTD significantly reduced protein expression of TRPV1 and TRPA1 in dorsal root ganglia and skins of injured paw. Collectively, our data demonstrate firstly that WTD exerts antinociceptive activity in inflammatory conditions by attenuating mechanical, cold, and heat hypersensitivities. This antinociceptive effect may result in part from inhibiting the activities of TRPV1, TRPA1, and TRPM8, and the suppression of TRPV1 and TRPA1 protein by WTD was also highly effective. These findings suggest that WTD might be an attractive and suitable therapeutic agent for the management of chronic inflammatory pain.

  7. The complete mitochondrial genome and its remarkable secondary structure for a stonefly Acroneuria hainana Wu (Insecta: Plecoptera, Perlidae).

    Science.gov (United States)

    Huang, Mingchao; Wang, Yuyu; Liu, Xingyue; Li, Weihai; Kang, Zehui; Wang, Kai; Li, Xuankun; Yang, Ding

    2015-02-15

    The Plecoptera (stoneflies) is a hemimetabolous order of insects, whose larvae are usually used as indicators for fresh water biomonitoring. Herein, we describe the complete mitochondrial (mt) genome of a stonefly species, namely Acroneuria hainana Wu belonging to the family Perlidae. This mt genome contains 13 PCGs, 22 tRNA-coding genes and 2 rRNA-coding genes that are conserved in most insect mt genomes, and it also has the identical gene order with the insect ancestral gene order. However, there are three special initiation codons of ND1, ND5 and COI in PCGs: TTG, GTG and CGA, coding for L, V and R, respectively. Additionally, the 899-bp control region, with 73.30% A+T content, has two long repeated sequences which are found at the 3'-end closing to the tRNA(Ile) gene. Both of them can be folded into a stem-loop structure, whose adjacent upstream and downstream sequences can be also folded into stem-loop structures. It is presumed that the four special structures in series could be associated with the D-loop replication. It might be able to adjust the replication speed of two replicate directions. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Preconditioning with Gua Lou Gui Zhi decoction enhances H2O2-induced Nrf2/HO-1 activation in PC12 cells

    Science.gov (United States)

    MAO, JINGJIE; LI, ZUANFANG; LIN, RUHUI; ZHU, XIAOQIN; LIN, JIUMAO; PENG, JUN; CHEN, LIDIAN

    2015-01-01

    Spasticity is common in various central neurological conditions, including after a stroke. Such spasticity may cause additional problems, and often becomes a primary concern for afflicted individuals. A number of studies have identified nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a key regulator in the adaptive survival response to oxidative stress. Elevated expression of Nrf2, combined with heme oxygenase 1 (HO-1) resistance, in the central nervous system is known to elicit key internal and external oxidation protection. Gua Lou Gui Zhi decoction (GLGZD) is a popular traditional Chinese formula with a long history of clinical use in China for the treatment of muscular spasticity following a stroke, epilepsy or a spinal cord injury. However, the mechanism underlying the efficacy of the medicine remains unclear. In the present study, the antioxidative effects of GLGZD were evaluated and the underlying molecular mechanisms were investigated, using hydrogen peroxide (H2O2)-induced rat pheochromocytoma cells (PC12 cells) as an in vitro oxidative stress model of neural cells. Upon application of different concentrations of GLGZD, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay and ATP measurement were conducted to assess the impact on PC12 cell proliferation. In addition, inverted microscopy observations, and the MTT and ATP assessments, revealed that GLGZD attenuated H2O2-induced oxidative damage and signaling repression in PC12 cells. Furthermore, the mRNA and protein expression levels of Nrf2 and HO-1, which are associated with oxidative stress, were analyzed using reverse transcription quantitative polymerase chain reaction (PCR) and confocal microscopy. Confocal microscopy observations, as well as the quantitative PCR assay, revealed that GLGZD exerted a neuroprotective function against H2O2-induced oxidative damage in PC12 cells. Therefore, the results demonstrated that GLGZD protected PC12 cells injured by H2O2, which may be

  9. Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

    Directory of Open Access Journals (Sweden)

    Zhang W

    2016-05-01

    Full Text Available Wen Zhang,1,* Li Wei,2,* Wenjing Yu,1 Xia Cui,1 Xiaofang Liu,2 Qian Wang,1 Sumei Wang2 1Department of Pediatrics, The Third Affiliated Hospital, 2Department of Pediatrics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Jian-Pi-Zhi-Dong Decoction (JPZDD is a dedicated treatment of Tourette syndrome (TS. The balance of neurotransmitters in the cortico-striato-pallido-thalamo-cortical network is crucial to the occurrence of TS and related to its severity. This study evaluated the effect of JPZDD on glutamate (Glu and γ-aminobutyric acid (GABA and their receptors in a TS rat model.Materials and methods: Rats were divided into four groups (n=12 each. TS was induced in three of the groups by injecting them with 3,3'-iminodipropionitrile for 7 consecutive days. Two model groups were treated with tiapride (Tia or JPZDD, while the control and the remaining model group were gavaged with saline. Behavior was assessed by stereotypic score and autonomic activity. Striatal Glu and GABA contents were detected using microdialysis. Expressions of N-methyl-D-aspartate receptor 1 and GABAA receptor (GABAAR were observed using Western blot and real-time polymerase chain reaction.Results: Tia and JPZDD groups had decreased stereotypy compared with model rats; however, the JPZDD group showed a larger decrease in stereotypy than the Tia group at a 4-week time point. In a spontaneous activity test, the total distance of the JPZDD and Tia groups was significantly decreased compared with the model group. The Glu levels of the model group were higher than the control group and decreased with Tia or JPZDD treatment. The GABA level was higher in the model group than the control group. Expressions of GABAAR protein in the model group were higher than in the control group. Treatment with Tia or JPZDD reduced the expression of GABAAR protein. In the case of the m

  10. [A Study on the quotations in the Wu xing da yi (The Gist of Five Phases) cited from Nei jing (Inner Canon)].

    Science.gov (United States)

    Wang, Zheng-Shan; Zhang, Qi-Cheng

    2013-07-01

    In the Wu xing da yi (The Gist of Five Phases), written by Xiao Ji of the Sui Dynasty, there were 9 quotations cited from Huang di nei jing (Inner Canon of Huangdi). By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages.

  11. [A molecular epidemiological study of KI polyomavirus and WU polyomavirus in children with acute respiratory infection in Tianjin, China].

    Science.gov (United States)

    Lin, Shu-Xiang; Wang, Wei; Guo, Wei; Yang, Hong-Jiang; Ma, Bai-Cheng; Fang, Yu-Lian; Xu, Yong-Sheng

    2017-07-01

    To investigate the relationship of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) with acute respiratory infection in children in Tianjin, China. A total of 3 730 nasopharyngeal secretions were collected from hospitalized children with acute respiratory infection in Tianjin Children's Hospital from January 2011 to December 2013. Viral nucleic acid was extracted, and virus infection (KIPyV and WUPyV) was determined by PCR. Some KIPyV-positive and WUPyV-positive PCR products were subjected to sequencing. Sequencing results were aligned with the known gene sequences of KIPyV and WUPyV to construct a phylogenetic tree. Amplified VP1 fragments of KIPyV were inserted into the cloning vector (PUCm-T) transformed into E. coli competent cells. Positive clones were identified by PCR and sequencing. The nucleotide sequences were submitted to GenBank. In addition, another seven common respiratory viruses in all samples were detected by direct immunofluorescence assay. In the 3 730 specimens, the KIPyV-positive rate was 12.14% (453/3 730) and the WUPyV-positive rate was 1.69% (63/3 730). The mean infection rate of KIPyV was significantly higher in June and July, while the mean infection rate of WUPyV peaked in February and March. Most of the KIPyV-positive or WUPyV-positive children were infections with KIPyV, WUPyV, and other respiratory viruses were observed in the children. The co-infection rate was 2.31% (86/3 730) and there were nine cases of co-infections with WUPyV and KIPyV. Thirty-five KIPyV-positive and twelve WUPyV-positive PCR products were sequenced and the alignment analysis showed that they had high homology with the known sequences (94%-100% vs 95%-100%). The VP1 gene sequences obtained from two KIPyV strains in this study were recorded in GenBank with the accession numbers of KY465925 and KY465926. For some children with acute respiratory infection in Tianjin, China, the acute respiratory infection may be associated with KIPyV and WUPy

  12. Ultra high performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry for the rapid analysis of constituents in the traditional Chinese medicine formula Wu Ji Bai Feng Pill.

    Science.gov (United States)

    Duan, Shengnan; Qi, Wen; Zhang, Siwen; Huang, Kunkun; Yuan, Dan

    2017-10-01

    An ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in both positive and negative ion modes was established in order to comprehensively investigate the major constituents in Wu Ji Bai Feng Pill. Briefly, a Waters ACQUITY UPLC HSS C 18 column was used to separate the aqueous extract of Wu Ji Bai Feng Pill. A total of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid v/v were used as the mobile phase. All analytes were determined using quadrupole time-of-flight mass spectrometry with electrospray ionization source in positive and negative ion modes. At length, a total of 173 components including flavones and their glycosides, monoterpene glycosides, triterpene saponins, phenethylalchohol glycosides, iridoid glycosides, phthalides, tanshinones, phenolic acids, sesquiterpenoids and cyclopeptides were identified or tentatively characterized in Wu Ji Bai Feng Pill in an analysis of 16.0 min based on the accurate mass and tandem mass spectrometry behaviors. The developed method is rapid and highly sensitive to characterize the chemical constituents of Wu Ji Bai Feng Pill, which could not only be used for chemical standardization and quality control of Wu Ji Bai Feng Pill, but also be helpful for further study in vivo metabolism of Wu Ji Bai Feng Pill. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Temporal Courses in EEG Theta and Alpha Activity in the Dynamic Health Qigong Techniques Wu Qin Xi and Liu Zi Jue

    Directory of Open Access Journals (Sweden)

    Diana Henz

    2018-01-01

    Full Text Available Health Qigong is a common technique of Traditional Chinese Medicine applied to strengthen mental and physical health. Several studies report increases in EEG theta and alpha activity after meditative Qigong techniques indicating a relaxed state of mind. To date, little is known on the effects of dynamic Health Qigong techniques that comprise bodily movements on brain activity. In the current study, we compared effects of two dynamic Health Qigong techniques on EEG brain activity. Subjects performed the techniques Wu Qin Xi (five animals play and Liu Zi Jue (six healing sounds in a within-subjects design. Eyes-open and eyes-closed resting EEG was recorded before and immediately after each 15-min practice block. Additionally, the Profile of Mood States (POMS questionnaire was administered at pretest, and after each 15-min practice block. Results show a decrease in alpha activity after 15 min, followed by an increase after 30 min in the Health Qigong technique Liu Zi Jue. Theta activity was decreased after 15 min, followed by an increase after 30 min in the technique Wu Qin Xi. Results of the POMS indicated an increased vigor-activity level with decreased fatigue and tension-anxiety levels in both techniques after 30 min of practice. Our results demonstrate different temporal dynamics in EEG theta and alpha activity for the Health Qigong techniques Wu Qin Xi and Liu Zi Jue. We hypothesize that the found brain activation patterns result from different attentional focusing styles and breathing techniques performed during the investigated Health Qigong techniques.

  14. Enzymatic characterization and gene identification of aconitate isomerase, an enzyme involved in assimilation of trans-aconitic acid, from Pseudomonas sp. WU-0701.

    Science.gov (United States)

    Yuhara, Kahori; Yonehara, Hiromi; Hattori, Takasumi; Kobayashi, Keiichi; Kirimura, Kohtaro

    2015-11-01

    trans-Aconitic acid is an unsaturated organic acid that is present in some plants such as soybean and wheat; however, it remains unclear how trans-aconitic acid is degraded and/or assimilated by living cells in nature. From soil, we isolated Pseudomonas sp. WU-0701 assimilating trans-aconitic acid as a sole carbon source. In the cell-free extract of Pseudomonas sp. WU-0701, aconitate isomerase (AI; EC 5.3.3.7) activity was detected. Therefore, it seems likely that strain Pseudomonas sp. WU-0701 converts trans-aconitic acid to cis-aconitic acid with AI, and assimilates this via the tricarboxylic acid cycle. For the characterization of AI from Pseudomonas sp. WU-0701, we performed purification, determination of enzymatic properties and gene identification of AI. The molecular mass of AI purified from cell-free extract was estimated to be ~ 25 kDa by both SDS/PAGE and gel filtration analyses, indicating that AI is a monomeric enzyme. The optimal pH and temperature of purified AI for the reaction were 6.0 °C and 37 °C, respectively. The gene ais encoding AI was cloned on the basis of the N-terminal amino acid sequence of the protein, and Southern blot analysis revealed that only one copy of ais is located on the bacterial genome. The gene ais contains an ORF of 786 bp, encoding a polypeptide of 262 amino acids, including the N-terminal 22 amino acids as a putative periplasm-targeting signal peptide. It is noteworthy that the amino acid sequence of AI shows 90% and 74% identity with molybdenum ABC transporter substrate-binding proteins of Pseudomonas psychrotolerans and Xanthomonas albilineans, respectively. This is the first report on purification to homogeneity, characterization and gene identification of AI. The nucleotide sequence of ais described in this article is available in the DDBJ/EMBL/GenBank nucleotide sequence databases under the Accession No. LC010980. © 2015 FEBS.

  15. Overexpression of the NADP+-specific isocitrate dehydrogenase gene (icdA) in citric acid-producing Aspergillus niger WU-2223L.

    Science.gov (United States)

    Kobayashi, Keiichi; Hattori, Takasumi; Hayashi, Rie; Kirimura, Kohtaro

    2014-01-01

    In the tricarboxylic acid (TCA) cycle, NADP(+)-specific isocitrate dehydrogenase (NADP(+)-ICDH) catalyzes oxidative decarboxylation of isocitric acid to form α-ketoglutaric acid with NADP(+) as a cofactor. We constructed an NADP(+)-ICDH gene (icdA)-overexpressing strain (OPI-1) using Aspergillus niger WU-2223L as a host and examined the effects of increase in NADP(+)-ICDH activity on citric acid production. Under citric acid-producing conditions with glucose as the carbon source, the amounts of citric acid produced and glucose consumed by OPI-1 for the 12-d cultivation period decreased by 18.7 and 10.5%, respectively, compared with those by WU-2223L. These results indicate that the amount of citric acid produced by A. niger can be altered with the NADP(+)-ICDH activity. Therefore, NADP(+)-ICDH is an important regulator of citric acid production in the TCA cycle of A. niger. Thus, we propose that the icdA gene is a potentially valuable tool for modulating citric acid production by metabolic engineering.

  16. Wu-Chia-Pi Solution Attenuates Carbon Tetrachloride-Induced Hepatic Injury through the Antioxidative Abilities of Its Components Acteoside and Quercetin

    Directory of Open Access Journals (Sweden)

    Ching-Chiung Wang

    2012-12-01

    Full Text Available Wu-Chia-Pi medicated wine, composed nine Chinese medicines soaked in 35% alcohol, is widely used in Asia for its health-promoting functions. However, long-term consumption of alcohol could result in liver dysfunction. In this study, Wu-Chia-Pi solution (WCPS and extract (WCPE were prepared by modification of the principals given by the Committee on Chinese Medicine and Pharmacy in Taiwan. The aim of this study was to explore the protective effect of WCPS against carbon tetrachloride (CCl4-induced liver injury and to clarify its active component(s. Antioxidative effects of the test samples were evaluated via MDA inhibition, catalase activity and DPPH-scavenging assays. HPLC was used to analysis the active components. Results showed that WCPS (1 and 5 mL/kg significantly prevented CCl4-induced liver injury without chronic liver toxicity. Referring to the antioxidative activities, WCPE displayed significant MDA inhibitory and DPPH-scavenging activities with IC50 values of 0.91 ± 0.03 and 0.60 ± 0.04 mg/mL, respectively. Catalase activity was also enhanced by treatment of WCPE, acteoside and quercetin. Therefore, we suggest that acteoside and quercetin are the major contributors to the antioxidative and hepatoprotective activities of WCPS, and a possible mechanism could be mediated through reduction of oxidative stress.

  17. Tentative characterization of precursor compounds and co-factors of pigment formation in production of 'wu mi' from Vaccinium bracteatum Thunb. Leaves.

    Science.gov (United States)

    Fan, Mingcong; Fan, Yihui; Huang, Weiping; Wang, Li; Li, Yan; Qian, Haifeng; Zhang, Hui; Qi, Xiguang

    2018-10-01

    Vaccinium bracteatum leaves (VBTL) are traditionally used in China to dye rice grains, which assume a deep blue color, named 'Wu mi'. Information on the mechanism of pigment formation is limited. In this study, CIELAB color space parameters were used to represent the color of 'Wu mi'. Precursor compounds of pigments formed during the dyeing process were identified by UPLC Q-TOF MS analysis. The changes in co-factors for pigment formation in VBTL were measured at different growth stages. The L ∗ and b ∗ values of dyed rice increased as the leaves aged, whereas a ∗ values showed irregular changes. Six compounds were tentatively identified as pigment precursors by UPLC Q-TOF MS analysis. The pH and β-glucosidase activity at different growth stages of VBTL were indicated to be crucial co-factors for pigment formation. A tentative hypothesis is presented that iridoid glycosides are hydrolyzed by acids and β-glucosidases to form a dialdehyde structure that binds covalently with amino residues of lysine side chains in rice protein molecules. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Ssang Yong 2014 Remote Sensing Experiment

    Science.gov (United States)

    2016-05-25

    stems from multiple sources: the ocean waves reaching the sands, rivers...I ~ I I I I I 350 550 750 950 1150 1350 1550 1750 1950 2150 2350 Wavelength, nm G-8           Cll ... <: ’" 1:: Cll ...0.6 0.5 0.4 Cll a: 0.3 0 .2 0.1 0.6 0.5 0.4 Cll ... <: ’" 1:: Cll ;;::: Cll a: 0.3 0.2 0.1 DG-2-4 1 1 I I I I ’ I I 1 11 1 Il l I 1

  19. Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.

    Science.gov (United States)

    Liu, Li; Ma, Hongyue; Tang, Yuping; Chen, Wenxing; Lu, Yin; Guo, Jianming; Duan, Jin-Ao

    2012-01-01

    The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions, the estrogen-like activity of 22 compounds was above 60% in 20 μg mL(-1). Furthermore, theoretical affinity of these compounds was certificated using the functional virtual screen of ER-α modulators by FlexX-Pharm. The accuracy of functional virtual screening of ER-α modulators could reach to 77.27%. The results showed that some compounds, such as organic acids and flavones in SWT series decoctions could be used as selective estrogen receptor modulators (SERMs) and could be selected for further development as potential agents for estrogen related diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats.

    Science.gov (United States)

    Dong, Xian-Zhe; Li, Zhao-Liang; Zheng, Xiao-Li; Mu, Li-Hua; Zhang, Gang-qiang; Liu, Ping

    2013-12-12

    Ding-Zhi-Xiao-Wan (DZ, also known as Kai-Xin-San) is a famous traditional Chinese medicine used for the treatment of emotional disease. Previously, we have found that in a variety of animal models of depression (such as tail suspension model, model of chronic fatigue and forced swimming model) DZ demonstrated significant antidepressant behavior and promoted the production of 5-hydroxytryptamine (5-HT). However, the mechanisms of 5-HT regulation are still unclear. Therefore, the current study is designed to further investigate the antidepressant effect of DZ by observing its influence on 5-HT synthesis, metabolism, transport and other key links, so as to clarify the molecular mechanism of its 5-HT regulation. Solitary rising combined with the chronic unpredictable mild stress (CMS) was used to establish the rat model of depression. The rats were given DZ for 3 weeks, the behavior change and the following items in hippocampus and prefrontal cortex were detected simultaneously: 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), tryptophan hydroxylase (TPH), aromatic amino acid decarboxylase (AADC), monoamine oxidase (MAO) and 5-HT transporter (5-HTT) were observed. Our results showed that treatment with the DZ significantly improved the behavior and simultaneously increased the 5-HT level in the hippocampus, prefrontal cortex tissues and hippocampus extracellular of depressive rats. In future studies revealed that DZ could significantly increase the protein and mRNA expression of the key enzymes TPH during the 5-HT synthesis process in the hippocampus and prefrontal cortex of the depressed rats, and suppress the expression of 5-HTT protein and mRNA at the same time. But it had no effects on MAO-A and MAO-B activities. We believe that antidepressant effect of DZ is caused by the increase of 5-HT synthesis and reduction of 5-HT re-uptake, and eventually increase the content of 5-HT in the brain and the synaptic gaps. © 2013 Published by Elsevier Ireland Ltd.

  1. Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

    Science.gov (United States)

    Sun, Lili; Yang, Jianwen; Wang, Meng; Zhang, Huijie; Liu, Yanan; Ren, Xiaoliang; Qi, Aidi

    2015-11-10

    Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stability. The objective of this study was to determine the associated-extraction efficiency of various CDs in XZN. Three various type CDs were evaluated, including native CDs (α-CD, β-CD), hydrophilic CD derivatives (HP-β-CD and Me-β-CD), and ionic CD derivatives (SBE-β-CD and CM-β-CD). An ultra high-performance liquid chromatography (UHPLC) fingerprint was applied to determine the components in CD extracts and original aqueous extract (OAE). A counterpropagation artificial neural network (CP-ANN) was used to analyze the components in different extracts and compare the selective extraction of various CDs. Extraction efficiencies of the various CDs in terms of extracted components follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native CDs>OAE. Besides, different types of CDs have their own selective extraction and ionic CD derivatives present the strongest associated-extraction efficiency. Antioxidant potentials of various extracts were evaluated by determining the inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for DPPH and hydroxyl radicals. The order of extraction efficiencies of the various CDs relative to antioxidant activities is as follows: SBE-β-CD>CM-β-CD>HP-β-CD>Me-β-CD>β-CD>α-CD. It can be demonstrated that all of the CDs studied increase the extraction efficiency and that ionic CD derivatives (SBE-β-CD and CM-β-CD) present the highest extraction capability in terms of amount extracted and antioxidant activities of extracts. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Structural and Biochemical Characterization of BdsA from Bacillus subtilis WU-S2B, a Key Enzyme in the “4S” Desulfurization Pathway

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    Tiantian Su

    2018-02-01

    Full Text Available Dibenzothiophene (DBT and their derivatives, accounting for the major part of the sulfur components in crude oil, make one of the most significant pollution sources. The DBT sulfone monooxygenase BdsA, one of the key enzymes in the “4S” desulfurization pathway, catalyzes the oxidation of DBT sulfone to 2′-hydroxybiphenyl 2-sulfonic acid (HBPSi. Here, we determined the crystal structure of BdsA from Bacillus subtilis WU-S2B, at the resolution of 2.2 Å, and the structure of the BdsA-FMN complex at 2.4 Å. BdsA and the BdsA-FMN complex exist as tetramers. DBT sulfone was placed into the active site by molecular docking. Seven residues (Phe12, His20, Phe56, Phe246, Val248, His316, and Val372 are found to be involved in the binding of DBT sulfone. The importance of these residues is supported by the study of the catalytic activity of the active site variants. Structural analysis and enzyme activity assay confirmed the importance of the right position and orientation of FMN and DBT sulfone, as well as the involvement of Ser139 as a nucleophile in catalysis. This work combined with our previous structure of DszC provides a systematic structural basis for the development of engineered desulfurization enzymes with higher efficiency and stability.

  3. The complete mitochondrial genome of the styloperlid stonefly species Styloperla spinicercia Wu (Insecta: Plecoptera) with family-level phylogenetic analyses of the Pteronarcyoidea.

    Science.gov (United States)

    Wang, Ying; Cao, Jinjun; Li, Weihai

    2017-03-13

    We present the complete mitochondrial (mt) genome sequence of the stonefly, Styloperla spinicercia Wu, 1935 (Plecoptera: Styloperlidae), the type species of the genus Styloperla and the first complete mt genome for the family Styloperlidae. The genome is circular, 16,129 base pairs long, has an A+T content of 70.7%, and contains 37 genes including the large and small ribosomal RNA (rRNA) subunits, 13 protein coding genes (PCGs), 22 tRNA genes and a large non-coding region (CR). All of the PCGs use the standard initiation codon ATN except ND1 and ND5, which start with TTG and GTG. Twelve of the PCGs stop with conventional terminal codons TAA and TAG, except ND5 which shows an incomplete terminator signal T. All tRNAs have the classic clover-leaf structures with the dihydrouridine (DHU) arm of tRNASer(AGN) forming a simple loop. Secondary structures of the two ribosomal RNAs are presented with reference to previous models. The structural elements and the variable numbers of tandem repeats are described within the control region. Phylogenetic analyses using both Bayesian (BI) and Maximum Likelihood (ML) methods support the previous hypotheses regarding family level relationships within the Pteronarcyoidea. The genetic distance calculated based on 13 PCGs and two rRNAs between Styloperla sp. and S. spinicercia is provided and interspecific divergence is discussed.

  4. Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts.

    Science.gov (United States)

    Wu, Chi-Ming; Chen, Po-Chun; Li, Te-Mao; Fong, Yi-Chin; Tang, Chih-Hsin

    2013-10-24

    Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is widely used for the treatment of gynopathies diseases such as menstrual discomfort, climacteric syndrome, dysmenorrhea, and other estrogen-related diseases. Recent studies have shown that SWT can treat primary dysmenorrhea, have anti-pruritic anti-inflammatory effects, and protect against radiation-induced bone marrow damage in an animal model. It has been reported that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption. However, the effect of SWT on bone cell function has not yet been reported. Alkaline phosphatase (ALP), bone morphogenetic proteins (BMP)-2, and osteopontin (OPN) mRNA expression was analyzed by qPCR. The mechanism of action of SWT extract was investigated using western blotting. The in vivo anti-osteoporotic effect of SWT extract was assessed in ovariectomized mice. Here, we report that SWT increases ALP, BMP-2, and OPN expression as well as bone mineralization. In addition, we show that the PI3K, Akt, and NF-κB signaling pathways may be involved in the SWT-mediated increase in gene expression and bone mineralization. Notably, treatment of mice with SWT extract prevented bone loss induced by ovariectomy in vivo. SWT may be used to stimulate bone formation for the treatment of osteoporosis.

  5. Identification of Multiple Ingredients for a Traditional Chinese Medicine Preparation (Bu-yang-huan-wu-tang by Liquid Chromatography Coupled with Tandem Mass Spectrometry

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    Tung-Hu Tsai

    2013-09-01

    Full Text Available Bu-yang-huan-wu-tang (BYHWT is a popular Traditional Chinese Medicine formula consisting of seven herbal medicines (Astragalus membranaceus, Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Carthamus tinctorius, Amygdalus persica and Pheretima aspergillum, that has been used in China for centuries to overcome stroke-induced disability. To ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass spectrometry (LC-MS/MS method for quantitative analysis of the major constituents in BYHWT. The herbal ingredients consisting of the cycloartane-type triterpene glycosides of astragaloside I, astragaloside II and astragaloside IV; isoflavones of formononetin, ononin calycosin, calycosin-7-O-β-d-glucoside; ligustilide and paeoniflorin were separated on a C18 column with gradient elution of methanol/10 mM ammonium acetate buffer–formic acid (100:0.1, v/v. This study was performed by a mass spectrometer using electrospray ionization (ESI with positive ionization ions monitored in the multiple reaction-monitoring (MRM mode. The linearity, accuracy, precision, limit of detection (LOD and lower limit of quantification (LLOQ were validated for this quantification method, and the sensitivity, reliability and reproducibility were all confirmed. The experiments provided a good method for analyzing BYHWT extracts. This study also quantitated the active components in various brands of commercially available products. The results indicated that the pharmaceutical industrial products of BYHWT exhibited considerable variation in their contents of the herbal compounds.

  6. Peng et al., Afr J Tradit Complement Altern Med. (2015) 12(5):35-45 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    as a kind of specific application of syndrome differentiation, You Gu Wu Yun, documented .... Zhi-Zhu-Wan (ZZW), a famous Chinese medical preparation used to treat functional dyspepsia, contains Aurantii fructus ..... Abdominal pain, vomiting,.

  7. Contamination and Human Health Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Oysters After the Wu Yi San Oil Spill in Korea.

    Science.gov (United States)

    Loh, Andrew; Yim, Un Hyuk; Ha, Sung Yong; An, Joon Geon; Kim, Moonkoo

    2017-07-01

    After the collision of the Singapore-registered oil tanker M/V Wu Yi San into the oil terminal of Yeosu, Korea on January 31, 2014, approximately 900 m 3 of oil and oil mixture were released from the ruptured pipelines. The oil affected more than 10 km of coastline along Gwangyang Bay. Emergency oil spill responses recovered bulk oil at sea and cleaned up the stranded oil on shore. As part of an emergency environmental impact assessment, region-wide monitoring of oil contamination in oyster had been conducted for 2 months. Highly elevated concentrations of polycyclic aromatic hydrocarbons (PAHs) were detected at most of the spill affected sites. Four days after the spill, the levels of PAHs in oysters increased dramatically to 627-81,000 ng/g, the average of which was 20 times higher than those found before the spill (321-4040 ng/g). The level of PAHs in these oysters increased until 10 days after the spill and then decreased. Due to the strong tidal current and easterly winter winds, the eastern part of the Bay-the Namhae region-was heavily contaminated compared with other regions. The accumulation and depuration of spilled oil in oyster corresponded with the duration and intensity of the cleanup activities, which is the first field observation in oil spill cases. Human health risk assessments showed that benzo[a]pyrene equivalent concentrations exceeded levels of concern in the highly contaminated sites, even 60 days after the spill.

  8. Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Zheng, Zhijie; Yan, Tongmeng; Chen, Weiying; Ye, Ling; Tang, Lan; Liu, Zhongqiu

    2012-08-01

    A rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry method was developed and validated for the determination and quantification of ephedrine in rat plasma samples. An Acquity UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) was used for chromatographic separation. Electrospray ionization in the positive mode was used, and the precursor-fragment ion pairs of m/z 166/148 and m/z 289/97 were adopted to characterize ephedrine and testosterone (internal standard), respectively. The method was validated using 10, 100 and 500 ng/mL of ephedrine. It demonstrated adequate levels of precision and accuracy, matrix effect, extraction recovery and stability. Linearity over the concentration range of 0.5-2000 ng/mL was acceptable with a correlation coefficient (r²) better than 0.990. To determine the pharmacokinetic behaviour of this sympathomimetic compound in the Sprague-Dawley rats, ephedrine hydrochloride, Herba Ephedrae single-herb and Wu Tou Tang decoctions were administered orally, and ephedrine hydrochloride was also administered by intravenous injection, and blood samples were collected over 24 h. Ephedrine was measured in plasma and pharmacokinetic parameters were determined by using the standard non-compartmental method and calculated by using Practical Pharmacokinetic Program-Version 87/97. The AUC(0-t) and T(max) values were significantly different (p Tang decoction compared to the other oral treatments, suggesting that some components in the decoction may reduce the bioavailability of ephedrine.

  9. Inhibition of Neoplastic Transformation and Chemically-Induced Skin Hyperplasia in Mice by Traditional Chinese Medicinal Formula Si-Wu-Tang

    Directory of Open Access Journals (Sweden)

    Mandy M. Liu

    2017-03-01

    Full Text Available Exploring traditional medicines may lead to the development of low-cost and non-toxic cancer preventive agents. Si-Wu-Tang (SWT, comprising the combination of four herbs, Rehmanniae, Angelica, Chuanxiong, and Paeoniae, is one of the most popular traditional Chinese medicines for women’s diseases. In our previous studies, the antioxidant Nrf2 pathways were strongly induced by SWT in vitro and in vivo. Since Nrf2 activation has been associated with anticarcinogenic effects, the purpose of this study is to evaluate SWT’s activity of cancer prevention. In the Ames test, SWT demonstrated an antimutagenic activity against mutagenicity induced by the chemical carcinogen 7,12-dimethylbenz(aanthracene (DMBA. In JB6 P+ cells, a non-cancerous murine epidermal model for studying tumor promotion, SWT inhibited epidermal growth factor (EGF-induced neoplastic transformation. The luciferase reporter gene assays demonstrated that SWT suppressed EGF-induced AP-1 and TNF-α-induced NF-κB activation, which are essential factors involved in skin carcinogenesis. In a DMBA-induced skin hyperplasia assay in ‘Sensitivity to Carcinogenesis’ (SENCAR mice, both topical and oral SWT inhibited DMBA-induced epidermal hyperplasia, expression of the proliferation marker Proliferating cell nuclear antigen (PCNA, and H-ras mutations. These findings demonstrate, for the first time, that SWT prevents tumor promoter and chemical-induced carcinogenesis in vitro and in vivo, partly by inhibiting DNA damage and blocking the activation of AP-1 and NF-κB.

  10. Wu Shangshi: One of the outstanding founders of Chinese modern geography%吴尚时对中国近代地理学的贡献与学术思想探讨

    Institute of Scientific and Technical Information of China (English)

    陈吉余; 吴超羽; 司徒尚纪

    2017-01-01

    Wu Shangshi (1904-1947) is considered one of the outstanding modem geographers emerging in the early 20th century in China.It is partly a result of the introduction of modem sciences from the West.Wu graduated as a gold medalist in Sun Yat-sen University (SYU) in 1928.He was then granted scholarship to study geography in France.He studied at the University of Lyon and the University of Grenoble under the supervision of A.Allix,M.Pardé and R.Blanchard,who was one of the best known students of V.de la Blanche.In 1934,Wu finished his study in France and returned to SYU to serve as a professor of geography.He was head of the department in 1939-1945,the most difficult and perilous period during the Japanese invasion.The university moved constantly to flee the flames of war.The thousands of miles across south and south-west China became Wu's research field.To continue one's work under such circumstances required an extraordinary determination and dedication to science.Excessive hard work in tough environments ruined his health.Wu died in 1947 at the age of 43.Among the second generation of Chinese modem geographers,Wu was a rare example of an integrated geographer.He combined comprehensive and complex geographic thought with a balanced approach between holistic perspective and detailed research.In addition,he possessed an outstanding ability to conduct field work.As such,many of his research findings have withstood the test of time and remain relevant to this day.For instance,Wu proposed "one belt and three arcs" to summarize the distribution of the mountain ranges in China.On the long debates of the stratigraphic sequence of the red bed formations "Danxia" and "Nanxiong",Wu suggested an alternative viewpoint that the two formations could be deposited at approximately the same time but in different faces and it has been confirmed by modem geologic investigation some 50 years later.Both contributions were listed on the "Great Geographical Discoveries of China in 100

  11. Molecular diversity analysis of Tetradium ruticarpum (WuZhuYu) in China based on inter-primer binding site (iPBS) markers and inter-simple sequence repeat (ISSR) markers.

    Science.gov (United States)

    Xu, Jing-Yuan; Zhu, Yan; Yi, Ze; Wu, Gang; Xie, Guo-Yong; Qin, Min-Jian

    2018-01-01

    "Wu zhu yu", which is obtained from the dried unripe fruits of Tetradium ruticarpum (A. Jussieu) T. G. Hartley, has been used as a traditional Chinese medicine for treatment of headaches, abdominal colic, and hypertension for thousands of years. The present study was designed to assess the molecular genetic diversity among 25 collected accessions of T. ruticarpum (Wu zhu yu in Chinese) from different areas of China, based on inter-primer binding site (iPBS) markers and inter-simple sequence repeat (ISSR) markers. Thirteen ISSR primers generated 151 amplification bands, of which 130 were polymorphic. Out of 165 bands that were amplified using 10 iPBS primers, 152 were polymorphic. The iPBS markers displayed a higher proportion of polymorphic loci (PPL = 92.5%) than the ISSR markers (PPL = 84.9%). The results showed that T. ruticarpum possessed high loci polymorphism and genetic differentiation occurred in this plant. The combined data of iPBS and ISSR markers scored on 25 accessions produced five clusters that approximately matched the geographic distribution of the species. The results indicated that both iPBS and ISSR markers were reliable and effective tools for analyzing the genetic diversity in T. ruticarpum. Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  12. Stereotactic body radiation therapy for patients with recurrent pancreatic adenocarcinoma at the abdominal lymph nodes or postoperative stump including pancreatic stump and other stump

    Directory of Open Access Journals (Sweden)

    Zeng XL

    2016-06-01

    Full Text Available Xian-Liang Zeng,* Huan-Huan Wang,* Mao-Bin Meng, Zhi-Qiang Wu, Yong-Chun Song, Hong-Qing Zhuang, Dong Qian, Feng-Tong Li, Lu-Jun Zhao, Zhi-Yong Yuan, Ping Wang Department of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China *These authors contributed equally to this work Background and aim: The aim of this study is to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT using CyberKnife in the treatment of patients with recurrent pancreatic adenocarcinoma at the abdominal lymph node or stump after surgery. Patients and methods: Between October 1, 2006 and May 1, 2015, patients with recurrent pancreatic adenocarcinoma at the abdominal lymph node or stump after surgery were enrolled and treated with SBRT at our hospital. The primary end point was local control rate after SBRT. Secondary end points were overall survival, time to symptom alleviation, and toxicity, assessed using the Common Terminology Criteria for Adverse Events version 4.0. Results: Twenty-four patients with 24 lesions (17 abdominal lymph nodes and seven stumps were treated with SBRT, of which five patients presented with abdominal lymph nodes and synchronous metastases in the liver and lung. The 6-, 12-, and 24-month actuarial local control rates were 95.2%, 83.8%, and 62.1%, respectively. For the entire cohort, the median overall survival from diagnosis and SBRT was 28.9 and 12.2 months, respectively. Symptom alleviation was observed in eleven of 14 patients (78.6% within a median of 8 days (range, 1–14 days after SBRT. Nine patients (37.5% experienced Common Terminology Criteria for Adverse Events version 4.0 grade 1–2 acute toxicities; one patient experienced grade 3 acute toxicity due to thrombocytopenia. Conclusion: SBRT is a safe and

  13. Un imaginaire dévoilé/déphasé. Stratégies narratives et mémoire culturelle dans le roman 54 des Wu Ming

    Directory of Open Access Journals (Sweden)

    Matteo Martelli

    2015-02-01

    Full Text Available This essay analyses the narrative strategies through which cultural memory is portrayed in 54, a novel in which Wu Ming (a collective of four Italian fiction writers suggests a literary mapping of the Fifties. This is obtained by a recovery of a shared imaginary tradition which is close to the reader, mixing fictional and historical characters, films, books, different genres of popular literature. Nevertheless, the rewriting of these imaginary traditions involves their displacement, a presentation which is constantly created from an unusual point of view. Thus, shifting the image of what is already known, the text inquires into several modalities of a questioning about cultural memory and its redefinition in relation to contemporary culture. By focusing on these elements, this study proposes an analysis which starts from the construction of the characters, the role of suspense and the adoption of multiple traditions of novel writing.

  14. Values,Thought Patterns and Personality Interpretation Method of Chinese Philosophy:A Case Study of Philosophical Interpretation of Li Zhi%价值观念、思维模式与中国哲学的人格诠释法--以李贽哲学与人生的诠释为例

    Institute of Scientific and Technical Information of China (English)

    李煌明

    2014-01-01

    As the personality problems of being a man with virtue is the core of Chinese philosophy ,the corre-sponding interpretation method of Chinese philosophy should be around the"personality",namely"personality in-terpretation method ."This interpretation method ,with traditional values and thinking mode for the kernel ,expands the two dimensions of ideal personality and real personality ,that is ,the transcendental life and natural reality ,and reveals the characteristics of Chinese philosophy ,the spirit of the nation and the presence of civilization .Take Li Zhi's philosophy as an example ,the Theory of Preserving Childlike Innocence embodies his true personality ;the inte-gration of"Empty (true)-Death (real)-know (new )"is its intrinsic thinking modes;"On Heroes"embodies his un-inhibited but promising personality with the ideas of contradictions and diversities .Its corresponding ideal personali-ty ,a real-life Li Zhi ,is a true maverick with courage and justice ,and a person who seems to be beyond the material world but actually concerns about the people .%“成人”“成德”的人格问题是中国哲学的核心内容,与此相应,中国哲学的诠释方法亦应围绕“人格”这一核心展开,此即“人格诠释法”。此诠释方法,以传统价值观念和思维模式为内核,从理想人格与现实人格即超越的生命与现实的生活二个层面展开,从而彰显中国哲学之特质、民族之精神与文明之面貌。以李贽哲学观之,“童心说”体现的是其真实日新的人格,“空(真)-寂(实)-知(新)”三者圆融是其内在思维模式;而“豪杰论”体现的是狂狷有为人格,“有两有对”“各异其性”是其内在思维模式。与其理想人格相应,现实生活中的李贽是一个标新立异而既方又直,“身游物外”而“心切救民”之人。

  15. Antihepatoma and Liver Protective Potentials of Ganoderma Lucidum (靈芝 Ling Zhi Fermented in a Medium Containing Black Soybean (黑豆 Hēi Dòu and Astragalus Membranaceus (生黃耆 Shēng Huáng Qí

    Directory of Open Access Journals (Sweden)

    Zheng-Yuan Su

    2013-04-01

    Full Text Available The antihepatoma activity and liver protective function of the fermentation products (5 L fermenator of Ganoderma lucidum (GL; 靈芝 Ling Zhi cultivated in a medium containing black soybean (BS; 黑豆 Hēi Dòu and Astragalus membranaceus (AM; 生黃耆 Shēng Huáng Qí at different fermentation temperatures were investigated in this study. Hep 3B cells pretreated with lovastatin were used to study the antihepatoma activity, and possible active components were analyzed by reverse-phase high-performance liquid chromatography. Carbon tetrachloride (CCl4-induced primary rat hepatocyte injury was further used to evaluate the liver protective activity of the fermentation products. While all the GL broth filtrates do not inhibit the growth of Hep 3B cells, the ethanolic extract from GL-2 mycelia (GL-2-mE, cultivated in the medium containing BS (50 g/L and AM (20 g/L at 24 °C for 11 days showed the best antihepatoma activity (IC50 26.6 μg/mL than the other ethanolic extracts from GL mycelia, GL fruiting body, BS, and AM did. The antihepatoma activities were correlated with some unknown active components in these samples. Furthermore, GL-2-mE (100 μg/mL without harmful effect on the growth of normal primary rat hepatocytes significantly maintained cell viability, reduced lactate dehydrogenase leakage, lowered lipid peroxidation, and increased glutathione peroxidase and glutathione S-transferase activities in the CCl4-induced damaged primary rat hepatocytes.

  16. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics.

    Science.gov (United States)

    Liu, Pei; Li, Zhenhao; Qian, Dawei; Li, Wei; Shang, Er-Xin; Duan, Jin-Ao

    2013-06-15

    A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of the three main bioactive compounds, i.e., ligustilide, dehydrocostuslactone and α-cyperone in dog plasma after oral administration of the essential oil of Xiang-Fu-Si-Wu Formula (XEO). Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mLmin(-1), using 0.1% formic acid-acetonitrile as mobile phase. The MS/MS ion transit ions monitored were 190.5→90.9 for ligustilide, 231.1→185.1 for dehydrocostuslactone, 219.2→123.0 for α-cyperone and 748.5→158.1 for IS. Method validation was performed as per Food and Drug Administration guidelines and the results met the acceptance criteria. The lower limit of quantification (LLOQ) achieved was 5.12ng/mL for ligustilide, 1.06ng/mL for dehydrocostuslactone and 1.89ng/mL for α-cyperone, respectively, and the calibration curves obtained were linear (r>0.99) over the concentration range approximately 1-1000ng/mL. The intra- and inter-day precision was less than 15% and the accuracy was within ±9.2%. After validation, this method was successfully applied to a pharmacokinetic study where dogs were orally given 0.3g/kg XEO, equivalent to 183.6mg/kg of ligustilide, 5.0mg/kg of dehydrocostuslactone and 26.2mg/kg of α-cyperone, respectively. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. Polyethylene glycol–polylactic acid nanoparticles modified with cysteine–arginine–glutamic acid–lysine–alanine fibrin-homing peptide for glioblastoma therapy by enhanced retention effect

    Directory of Open Access Journals (Sweden)

    Wu J

    2014-11-01

    Full Text Available Junzhu Wu,1,2,* Jingjing Zhao,1,3,* Bo Zhang,1 Yong Qian,1 Huile Gao,1 Yuan Yu,1 Yan Wei,1 Zhi Yang,1 Xinguo Jiang,1 Zhiqing Pang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 2School of Pharmacy, Dali University, Xiaguan, 3School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Abstract: For a nanoparticulate drug-delivery system, crucial challenges in brain-glioblastoma therapy are its poor penetration and retention in the glioblastoma parenchyma. As a prevailing component in the extracellular matrix of many solid tumors, fibrin plays a critical role in the maintenance of glioblastoma morphology and glioblastoma cell differentiation and proliferation. We developed a new drug-delivery system by conjugating polyethylene glycol–polylactic acid nanoparticles (NPs with cysteine–arginine–glutamic acid–lysine–alanine (CREKA; TNPs, a peptide with special affinity for fibrin, to mediate glioblastoma-homing and prolong NP retention at the tumor site. In vitro binding tests indicated that CREKA significantly enhanced specific binding of NPs with fibrin. In vivo fluorescence imaging of glioblastoma-bearing nude mice, ex vivo brain imaging, and glioblastoma distribution demonstrated that TNPs had higher accumulation and longer retention in the glioblastoma site over unmodified NPs. Furthermore, pharmacodynamic results showed that paclitaxel-loaded TNPs significantly prolonged the median survival time of intracranial U87 glioblastoma-bearing nude mice compared with controls, Taxol, and NPs. These findings suggested that TNPs were able to target the glioblastoma and enhance retention, which is a valuable strategy for tumor therapy. Keywords: CREKA peptide, nanoparticles, retention effect, paclitaxel, glioblastoma

  18. Anti-RhoC siRNAs inhibit the proliferation and invasiveness of breast cancer cells via modulating the KAI1, MMP9, and CXCR4 expression

    Directory of Open Access Journals (Sweden)

    Xu X

    2017-03-01

    Full Text Available Xu-Dong Xu,1 Han-Bin Shen,1 Li Zhu,2 Jian-Qin Lu,2 Lin Zhang,3 Zhi-Yong Luo,3 Ya-Qun Wu3 1Department of Thyroid and Breast Surgery, The Fifth Hospital of Wuhan, Hanyang District, 2Department of Oncology, 3Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China Abstract: Overexpression of RhoC in breast cancer cells indicates poor prognosis. In the present study, we aim to investigate the possible antitumor effects of anti-RhoC small-interfering RNA (siRNA in inflammatory breast cancer cells. In this study, a specific anti-RhoC siRNA was used to inhibit RhoC synthesis. Transfection of anti-RhoC siRNA into two IBC cells SUM149 and SUM190 induced extensive degradation of target mRNA and led to significant decrease in the synthesis of protein. Anti-RhoC siRNA inhibited cell proliferation and invasion, increased cell apoptosis, and induced cell cycle arrest in vitro. Moreover, the transfection of siRNA increased the expression of KAI1 and decreased the expression of MMP9 and CXCR4 in both mRNA and protein levels. Furthermore, transplantation tumor experiments in BALB/c-nu mice showed that intratumoral injection of anti-RhoC siRNA inhibited tumor growth and increased survival rate. Our results suggested that RhoC gene silencing with specific anti-RhoC siRNA would be a potential therapeutic method for metastatic breast cancer. Keywords: gene silencing, proliferation, apoptosis, cell cycle arrest

  19. Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang-Fu-Si-Wu Decoction effective fraction in normal and dysmenorrheal symptom rats.

    Science.gov (United States)

    Liu, Pei; Li, Wei; Li, Zhen-hao; Qian, Da-wei; Guo, Jian-ming; Shang, Er-xin; Su, Shu-lan; Tang, Yu-ping; Duan, Jin-ao

    2014-07-03

    Xiang-Fu-Si-Wu Decoction (XFSWD) has been widely used to treat primary dysmenorrhea in clinical practice for hundreds of years and shown great efficacy. One fraction of XFSWD, which was an elution product by macroporous adsorption resin from aqueous extract solution with 60% ethanol (XFSWE), showed great analgesic effect. The present study was conducted to investigate the possible pharmacokinetic and tissue distribution profiles of four major bioactive constituents (berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine) after oral administration of XFSWE in dysmenorrheal symptom rats, and to compare the difference between normal and dysmenorrheal symptom rats. Estradiol benzoate and oxytocin were used to produce dysmenorrheal symptom rat model. The experimental period was seven days. At the final day of experimental period, both normal and dysmenorrheal symptom rats were orally administrated with XFSWE, and then the blood and tissues samples were collected at different time points. Berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine in blood and tissue samples were determined by LC-MS/MS. Pharmacokinetic parameters were calculated from the plasma concentration-time data using non-compartmental methods. The differences of pharmacokinetic parameters among groups were tested by one-way analysis of variance (ANOVA). There were statistically significant differences (Pnormal and dysmenorrheal symptom rats that orally administered with same dosage of XFSWE. In tissue distribution study, the results showed that the overall trend was C(Spleen)>C(Liver)>C(Kidney)>C(Uterus)>C(Heart)>C(Lung)>C(Ovary)>C(Brain)>C(Thymus), C(M-60 min)>C(M-120 min)>C(M-30 min)>C(C-60 min)>C(C-120 min)>C(C-30 min). The contents of protopine in liver, spleen and uterus were more than that in other tissues of dysmenorrheal symptom rats. Compared to normal rats, partial contents of the compounds in dysmenorrheal symptom rats׳ tissues at different time points had significant

  20. Browse Title Index

    African Journals Online (AJOL)

    Items 501 - 550 of 1309 ... HH Tamboura, B Bayala, M Lompo, IP Guissou, L Sawadogo ... X Wang, Y-G Chen, L Ma, Z-H Li, J-Y Li, X-G Liu, J-L Zou, J-H Wu. Vol 11, No 2 ... Zhi-Jiang Wang, Wei Xu, Jian-Wen Liang, Cai-Sheng Wang, Yani Kang.

  1. http://dx.doi.org/10.4314/ajtcam.v10i4.6

    African Journals Online (AJOL)

    AJTCAM

    http://dx.doi.org/10.4314/ajtcam.v10i4.6. 36. CHEMOTHERAPEUTIC ACTIVITIES OF CARTHAMI FLOS AND ITS REVERSAL EFFECT ON. MULTIDRUG RESISTANCE IN CANCER CELLS. Jimmy Yiu-Cheong Wu*a, Zhi-Ling Yub, Wang-Fun Fongb, Yi-Qian Shia. aZhejiang Chinese Medical University, Hangzhou 310053, ...

  2. Hawking Temperature of Acoustic Black Hole Zhi Kun Xie

    Indian Academy of Sciences (India)

    Abstract. Using a new tortoise coordinate transformation, the Hawking radiation of the acoustic black hole was discussed by studying the Klein–. Gordon equation of scalar particles in the curve space-time. It was found that the Hawking temperature is connected with time and position on the event horizon. Key words.

  3. Retraction Note to: Ultra-High Strength and Ductile Lamellar-Structured Powder Metallurgy Binary Ti-Ta Alloys

    Science.gov (United States)

    Liu, Yong; Xu, Shenghang; Wang, Xin; Li, Kaiyang; Liu, Bin; Wu, Hong; Tang, Huiping

    2018-05-01

    The editors and authors have retracted the article, "Ultra-High Strength and Ductile Lamellar-Structured Powder Metallurgy Binary Ti-Ta Alloys" by Yong Liu, Shenghang Xu, Xin Wang, Kaiyang Li, Bin Liu, Hong Wu, and Huiping Tang (https://doi.org/10.1007/s11837-015-1801-1).

  4. The Frontier National Society Viewed by WU Luzhen:Case of East Simeng Survey in Inner Mongolia%吴禄贞视野中的边疆民族社会①--以内蒙古东四盟调查为例

    Institute of Scientific and Technical Information of China (English)

    王鹏辉

    2015-01-01

    Inner Mongolia Dongsimeng region formed Mongolian and Han mixed pattern of survival in Qing Dynasty, and formed an in-terdependent community of destiny. WU lu-zhen survey showing the internal crisis of Inner Mongolia Dongsimeng borderland ethnic society, involving many aspects,such as politics, livelihoods and economies, religion and customs, which showed its domestic policy and internation-al aggression interaction mechanism of social contradictions and resulted in the frontier ethnic society in Modern China.%有清一代,内蒙古东四盟地域已经形成蒙汉杂居的生存格局,并且结成相互依存的命运共同体。吴禄贞的调查呈现出内蒙古东四盟边疆民族社会的内在危机,涉及政治、生计与经济、宗教与风俗诸多方面,显现其国内新政与国际侵略互动的社会矛盾机制。内蒙古东四盟身处清末国内国际两种交冲的力量与历史传统的碰撞,逐渐生成中国近代的边疆民族社会。

  5. Lin-Na and Yong-Xiu Afr J Tradit Complement Altern Med. (2014) 11 ...

    African Journals Online (AJOL)

    cadewumi

    Evaluation of anti-athletic fatigue activity of Schizandra chinensis aqueous extracts in mice. Afr J Pharm Pharmacol 3: 593-597. 4. Cao, Y., Hu, Y., Liu, P., Zhao, H.X., Zhou, X.J., and Wei, Y.M. (2012). Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running ...

  6. SYNTHESES, STRUCTURES AND PROPERTIES Jian Wu1*, Fu

    African Journals Online (AJOL)

    Preferred Customer

    Printed in Ethiopia. © 2014 Chemical Society of Ethiopia ... 1Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi University ... The O–H···O and C–H···Cl hydrogen-bonding interactions play a significant role in.

  7. Supply chain management in selected clothing retail businesses / Jianling Wu

    OpenAIRE

    Wu, Jianling

    2004-01-01

    In today's highly competitive, global market place the pressure on organizations to find new ways to create and deliver value to customers grows ever strong. At the same time, market maturity combined with new sources of global competition has led to over-capacity in many industries leading to an inevitable pressure on price. Managers are increasingly interested in actively managing their supply chains because of environmental changes. The study is aimed to identify the importa...

  8. 对格里埃尔《声乐协奏曲》的两种演唱诠释---吴碧霞与德赛演唱的《声乐协奏曲》之比较%Interpretation of Two Types of Singing Performance of Gliere's"Vocal Concerto":A Comparison of"Vocal Con-certo"Sung by Wu Bixia and Natalie Dessay

    Institute of Scientific and Technical Information of China (English)

    张艳

    2015-01-01

    吴碧霞被誉为“中西合璧”的夜莺,无论在美声唱法还是民族唱法领域都有一定的造诣,演唱的歌曲都有丰富的表现力与感染力。纳塔利·德赛同样也被誉为20世纪末的“声音奇迹”,两个来自不同国度的歌唱家在演绎这首《声乐协奏曲》时,也有着不同的演唱风格与音响效果。通过对吴碧霞与德赛演唱的这首《声乐协奏曲》的比较分析,让我们更加清楚地认识到我国声乐发展的前景,并对两种风格的演唱进行文化的理解与思考。%Wu Bixia is hailed as a "nightingale" integrating the East and the West, as she has certain attainments in both bel canto and nazionale cantanti, and the songs sung by her are all highly expressive and attractive. Natalie Dessay is honored as a"vocal marvel" at the end of the 20th century. The two singers from two different countries have different singing styles and vo-cal effects when they sing"Vocal Concerto". Through a compara-tive analysis on"Vocal Concerto"sung by Wu Bixia and Natalie Dessay, we can more clearly learn about the prospect of the de-velopment of vocal music in China, thus understanding and re-flecting more about the cultures of the two styles.

  9. Kant's Categorical Imperative and Mou Zongsan's De Xing Zhi Zhi%牟宗三的德性之知与康德的绝对命令

    Institute of Scientific and Technical Information of China (English)

    刘晓民

    2013-01-01

    康德认为人不能有智的直觉,而牟宗三借用康德的智的直觉的观念,印证了在中国哲学中人是有智的直觉的.牟宗三在其著作中对康德的哲学进行了批判,认为康德哲学的缺陷在于隔离了本体和存在.然而,康德哲学和牟宗三笔下的中国哲学互有长处,没有孰优孰劣.

  10. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    Science.gov (United States)

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  11. On the Superluminal Motion of Radio-Loud AGNs Zhi-Bin Zhang1,2 ...

    Indian Academy of Sciences (India)

    xies—radiation mechanisms: non-thermal—quasars: general. 1. Introduction. Rees (1966) predicted that the transverse velocity of an object moving relativistically in some special directions may appear to exceed the speed of light. The apparent superluminal motion (SM) is essentially a geometric effect or a light travel-time.

  12. San luo xuan mo xing ji qi liang hua fen zhi fang fa yan tao

    NARCIS (Netherlands)

    Ye, Y.; Leydesdorff, L.; Wu, Y.

    2014-01-01

    A discussed study on the Triple Helix with its quantitative analysis method. With brief introduction to background and progress of Triple-Helix(TH) researches, it is clarified that TH quantitative methodology focuses on the indicator of synergy (T) as reduction of uncertainty that can be shaped

  13. Shifts in the pelagic ammonia-oxidizing microbial communities along the eutrophic estuary of Yong River in Ningbo City, China

    NARCIS (Netherlands)

    Zhang, Qiufang; Tang, Fang-Yuan; Zhou, Yang-Jing; Xu, Jirong; Chen, Heping; Wang, Ming-Juang; Laanbroek, H.J.

    2015-01-01

    BACKGROUND: Aerobic ammonia oxidation plays a key role in the nitrogen cycle, and the diversity of the responsible microorganisms is regulated by environmental factors. Abundance and composition of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) were investigated in the surface

  14. RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.

    Science.gov (United States)

    Zhong, Weiqiang; Jiang, Zongpei; Zhou, Tian-Biao

    2015-12-01

    .1177/1470320314566019 Tian-Biao Zhou, Xue-Feng Guo, Zongpei Jiang, and Hong-Yan Li Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population Journal of Renin-Angiotensin-Aldosterone System 1470320314563425, first published on February 1, 2015 doi: 10.1177/1470320314563425 Chun-Hua Yang and Tian-Biao Zhou Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314566221, first published on February 1, 2015 doi: 10.1177/1470320314566221 Chun-Hua Yang and Tian-Biao Zhou Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression Journal of Renin-Angiotensin-Aldosterone System 1470320314568521, first published on February 3, 2015 doi: 10.1177/1470320314568521 Articles published in an issue Guohui Liu, Tian-Biao Zhou, Zongpei Jiang, and Dongwen Zheng Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population Journal of Renin-Angiotensin-Aldosterone System March 2015 16: 165-171, first published on November 14, 2014 doi: 10.1177/1470320314557849 Weiqiang Zhong, Zhongliang Huang, Yong Wu, Zongpei Jiang, and Tian-Biao Zhou Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy Journal of Renin-Angiotensin-Aldosterone System September 2015 16: 660-665, first published on August 20, 2014 doi: 10.1177/1470320314524011.

  15. RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.

    Science.gov (United States)

    Yang, Chun-Hua; Zhou, Tian-Biao

    2015-12-01

    Jiang, and Hong-Yan Li Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population Journal of Renin-Angiotensin-Aldosterone System 1470320314563425, first published on February 1, 2015 doi: 10.1177/1470320314563425 Chun-Hua Yang and Tian-Biao Zhou Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314566221, first published on February 1, 2015 doi: 10.1177/1470320314566221 Chun-Hua Yang and Tian-Biao Zhou Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression Journal of Renin-Angiotensin-Aldosterone System 1470320314568521, first published on February 3, 2015 doi: 10.1177/1470320314568521 Articles published in an issue Guohui Liu, Tian-Biao Zhou, Zongpei Jiang, and Dongwen Zheng Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population Journal of Renin-Angiotensin-Aldosterone System March 2015 16: 165-171, first published on November 14, 2014 doi: 10.1177/1470320314557849 Weiqiang Zhong, Zhongliang Huang, Yong Wu, Zongpei Jiang, and Tian-Biao Zhou Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy Journal of Renin-Angiotensin-Aldosterone System September 2015 16: 660-665, first published on August 20, 2014 doi: 10.1177/1470320314524011.

  16. RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.

    Science.gov (United States)

    Zhou, Tian-Biao; Guo, Xue-Feng; Jiang, Zongpei; Li, Hong-Yan

    2015-12-01

    26, 2015 doi: 10.1177/1470320314566019 Tian-Biao Zhou, Xue-Feng Guo, Zongpei Jiang, and Hong-Yan Li Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population Journal of Renin-Angiotensin-Aldosterone System 1470320314563425, first published on February 1, 2015 doi: 10.1177/1470320314563425 Chun-Hua Yang and Tian-Biao Zhou Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314566221, first published on February 1, 2015 doi: 10.1177/1470320314566221 Chun-Hua Yang and Tian-Biao Zhou Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression Journal of Renin-Angiotensin-Aldosterone System 1470320314568521, first published on February 3, 2015 doi: 10.1177/1470320314568521 Articles published in an issue Guohui Liu, Tian-Biao Zhou, Zongpei Jiang, and Dongwen Zheng Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population Journal of Renin-Angiotensin-Aldosterone System March 2015 16: 165-171, first published on November 14, 2014 doi: 10.1177/1470320314557849 Weiqiang Zhong, Zhongliang Huang, Yong Wu, Zongpei Jiang, and Tian-Biao Zhou Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy Journal of Renin-Angiotensin-Aldosterone System September 2015 16: 660-665, first published on August 20, 2014 doi: 10.1177/1470320314524011.

  17. Joint Services Electronics Program. Electronics Research at the University of Texas at Austin.

    Science.gov (United States)

    1986-09-30

    White, Physics Kyoung II Kim , ECE John White, Aerospace Tae Sung Kim , ECE Murray Wolinsky, Physics Taiho Koh, ECE * L.A. Wu, Physics Tom Koonce...on Acutc.SpehadSignal Processing, Vol. 1, March 1984, San Diego, California, pp. - ’ -’.,"" 27. Kyoung 11 Kim and Edward J. Powers, "Digital Estimation...Craig Farley, ECE, M.S., May 1985, "The Migration and Activation of Impurities in Ion- Implanted Semiconductors." Dae Yong Kim , ECE, M.S., May 1985

  18. Wu et al., Afr J Tradit Complement Altern Med., (2018) 15 (1): 151 ...

    African Journals Online (AJOL)

    asdasd

    2017-12-29

    Dec 29, 2017 ... 1Department of Science and Technology and 2School of Biological Science and .... collected from Lu-mountain (Zibo, China) , and identified by the expert of plant taxonomy, Professor Shoujin FAN .... Biological Chemistry, 391, ... 21st century natural product research and drug development and traditional.

  19. Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China.

    Science.gov (United States)

    Zhu, Teng; Lu, Qing-Bin; Zhang, Shu-Yan; Wo, Ying; Zhuang, Lu; Zhang, Pan-He; Zhang, Xiao-Ai; Wei, Wei; Liu, Wei

    2017-05-01

    To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate. Altogether 122 (7.5%) of 1617 children found to be infected with WUPyV and 88 (72.1%) were coinfected with other viruses during 2012-2015. The phylogenetic analysis showed that 14 strains from our study formed two new clusters (Id and IIIc) within the Branch I and Branch III, respectively. WUPyV is persistently circulating in China. Surveillance on WUPyV infection in wider areas and long persistence is warranted.

  20. Reworked crustal of early Paleozoic WuYi Orogen revealed by receiver function data

    Science.gov (United States)

    Wei, Y.; Duan, Y.; Tian, X.; Zhao, Y.

    2017-12-01

    Intraplate orogenic belt, which occurs at the rigid and undeformable plate interiors, is a distinct new type of orogen rather than an interplate or plate marginal orogenic belt, whose deformation occurs exclusively at plate margins. Therefore, intraplate orogenic belts are the most obvious exception to the plate-tectonic paradigm, they are uncommon in Earth's history. The early Paleozoic Wuyi orogen in South China is one of the few examples of intraplate orogen, and is a key to understanding the process of intraplate orogenesis and global early Paleozoic geodynamics. In this study, we select teleseismic records from 45 mobile linear seismic stations deployed in Wuyi Mountain and 58 permanent stations setting in Jiangxi and Fujian provinces, from January 2011 to December 2012, and calculate the crustal thickness and average crustal Vp/Vs ratio using the H-κ stacking method. The main results include the following: 1) the crustal average Poission's ratio shows an increase tendency from land to sea, the interior of Wuyi orogen belt with an low ration less than 0.23, and the coastline with high ration which is up to 0.28, which indicate a very heterogeneous crustal structure and composition in Wuyi orogen and coast belt. 2) the crustal thickness ranges 28-34 km and shows a tendency of thinning from inland to coast in the region of SE China margin, which maight mean the eastern Eurasia lithospheric is extension and thinning induced by the subducted paleo-Pacific slab. To conclusion, we assume that Wuyi orogen experienced upper crustal thickening, lower crust and lithosphere delamination during the early Paleozoic orogeny, and lithosphere extension in Mesozoic. This research is founded by the Natural Science Foundation of China (41174052 and 41604048).

  1. Effect of Zhen-wu decoction on chronic heart failure in rats

    African Journals Online (AJOL)

    ... has been an increased hospitalization burden, and makes HF a global public health problem. The most effective and commonly used drugs for treatment of HF are angiotensin-converting enzyme (ACE) inhibitors, β-adrenoceptor blockers, and digitalis [5-7]. The American Heart. Association (AHA) and European Society of ...

  2. Selected Articles From Wu-Li T’Ung-Pao (Physics Bulletin) (Number 5, 1960)

    Science.gov (United States)

    1960-12-07

    seisstific research. W© had m©t eonstdsrabl© eueeeas.-’ Our ohe»ieal ®agi&®£>riag department had extracted’ rayos fsom the oomjs stock* Our...won. pi our ’diffusion process our *ch*in~^h.|tt~ X ^i"was.&böVO 85 percent and the saa responsible» for this iaehi&ic&l woxic vms only a high school

  3. and Jet Power/Emission in AGNs Zhongzu Wu1,∗ , Minfeng Gu2 ...

    Indian Academy of Sciences (India)

    Abstract. Neutral hydrogen (HI) 21-cm absorption has been detected against very powerful radio jets. In this paper, based on Gupta's sample. (Gupta et al. 2006), we present our preliminary study of the correlations between the HI column density N(HI) and the jet power, N(HI) versus the low frequency luminosity at 408 MHz, ...

  4. Effect of Zhen-wu decoction on chronic heart failure in rats | Liu ...

    African Journals Online (AJOL)

    Results: Compared with normal control group, ZWD group showed decreased arterial systolic pressure (SBP, 89.16 ± 17.27 mmHg), diastolic pressure (DBP, 72.54 ± 22.36 mmHg), mean arterial pressure (MAP, 72.64 ± 11.87 mmHg), heart rate (HR, 368.25 ± 39.12 beats/min), left ventricular systolic peak (LVSP, 105.27 ...

  5. Ignition delay time correlation of fuel blends based on Livengood-Wu description

    KAUST Repository

    Khaled, Fathi; Badra, Jihad; Farooq, Aamir

    2017-01-01

    observed for combustion phasing in homogeneous charge compression ignition (HCCI) predictions between simulations performed with detailed chemistry and calculations using the developed ignition delay correlation.

  6. Reviving ancient Chinese mathematics mathematics, history and politics in the work of Wu Wen-Tsun

    CERN Document Server

    Hudecek, Jiri

    2014-01-01

    Twentieth-century China has been caught between a desire to increase its wealth and power in line with other advanced nations, which, by implication, means copying their institutions, practices and values, whilst simultaneously seeking to preserve China's independence and historically formed identity. Over time, Chinese philosophers, writers, artists and politicians have all sought to reconcile these goals and this book shows how this search for a Chinese way penetrated even the most central, least contested area of modernity: science.Reviving Ancient Chinese Mathematics is a study of the life

  7. Can Medical Herbs Stimulate Regeneration or Neuroprotection and Treat Neuropathic Pain in Chemotherapy-Induced Peripheral Neuropathy?

    Directory of Open Access Journals (Sweden)

    Sven Schröder

    2013-01-01

    Full Text Available Chemotherapy-induced neuropathy (CIPN has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan, Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto, Huang Qi Wu Wu Tang (Ogikeishigomotsuto, and Shao Yao Gan Cao Tang (Shakuyakukanzoto. The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN.

  8. The satisfaction level of indigenous people towards planned housing development. Case study: Orang Asli Kg. Sejagong, Sri Medan, Yong Peng Johor

    Science.gov (United States)

    Kamaruddin, S. M.; Zaini, N. S.; Misni, A.; Ahmad, P.

    2018-02-01

    Orang Asli possesses a unique relationship with their traditional land. Indigenous people have their thoughts on development, life values, visions, needs, and priorities. The government through Department of Orang Asli Development or Jabatan Kebajikan Orang Asli (JAKOA) implemented various development programs such as structured settlement program, physical improvements such as Regrouping Plan (RPS), Village Restructuring project (PSK), New Village Plan (RKB) and Orang Asli settlement customary Land Survey (village) / Land Acquisition. Orang Asli Community. However, their sense of satisfaction towards the development implemented is rarely evaluated. This paper aims to highlight Orang Asli’s thoughts and level of satisfaction towards the planned housing development of their settlement. A mixed methodology was employed using survey and interview to record their thoughts. The findings suggest that the Orang Asli Community’s sense of satisfaction towards housing development has improved. However, their needs to adhere to their social traditions and norms such as living adjacent to relatives, surrounded by nature within a low-density environment must be respected.

  9. Lanthanide metal-organic frameworks

    International Nuclear Information System (INIS)

    Cheng, Peng

    2015-01-01

    This book contains the following nine chapters: lanthanide metal-organic frameworks: syntheses, properties, and potential applications (Stephen Fordham, Xuan Wang, Mathieu Bosch, Hong-Cai Zhou); 2. chiral lanthanide metal-organic frameworks (Weisheng Liu, Xiaoliang Tang); 3. Porous lanthanide metal-organic frameworks for gas storage and separation (Bin Li, Banglin Chen); 4. Luminescent lanthanide metal-organic frameworks (Xue-Zhi Song, Shu-Yan Song, Hong-Jie Zhang); 5. Metal-organic frameworks based on lanthanide clusters (Lian Chen, Feilong Jiang, Kang Zhou, Mingyan Wu, Maochun Hong); 6. metal-organic frameworks with d-f cyanide bridges: structural diversity, bonding regime, and magnetism (Marilena Ferbinteanu, Fanica Cimpoesu, Stefania Tanase); 7. transition-lanthanide heterometal-organic frameworks: synthesis, structures, and properties (Wei Shi, Ke Liu, Peng Cheng); 8: MOFs of uranium and the actinides (Juan Su, Jiesheng Chen); 9. Nanostructured and/or nanoscale lanthanide metal-organic frameworks (Zhonghao Zhang, Zhiping Zheng).

  10. Lanthanide metal-organic frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Peng (ed.) [Nankai Univ., Tianjin (China). Dept. of Chemistry

    2015-03-01

    This book contains the following nine chapters: lanthanide metal-organic frameworks: syntheses, properties, and potential applications (Stephen Fordham, Xuan Wang, Mathieu Bosch, Hong-Cai Zhou); 2. chiral lanthanide metal-organic frameworks (Weisheng Liu, Xiaoliang Tang); 3. Porous lanthanide metal-organic frameworks for gas storage and separation (Bin Li, Banglin Chen); 4. Luminescent lanthanide metal-organic frameworks (Xue-Zhi Song, Shu-Yan Song, Hong-Jie Zhang); 5. Metal-organic frameworks based on lanthanide clusters (Lian Chen, Feilong Jiang, Kang Zhou, Mingyan Wu, Maochun Hong); 6. metal-organic frameworks with d-f cyanide bridges: structural diversity, bonding regime, and magnetism (Marilena Ferbinteanu, Fanica Cimpoesu, Stefania Tanase); 7. transition-lanthanide heterometal-organic frameworks: synthesis, structures, and properties (Wei Shi, Ke Liu, Peng Cheng); 8: MOFs of uranium and the actinides (Juan Su, Jiesheng Chen); 9. Nanostructured and/or nanoscale lanthanide metal-organic frameworks (Zhonghao Zhang, Zhiping Zheng).

  11. Retracted: Long-term copper toxicity in apple trees (Malus pumila Mill) and bioaccumulation in fruits.

    Science.gov (United States)

    Sun, Bai-Ye; Kan, Shi-Hong; Zhang, Yan-Zong; Wu, Jun; Deng, Shi-Huai; Liu, Chun-Sheng; Yang, Gang

    2010-01-15

    The following article from Environmental Toxicology, 'Long-term Copper Toxicity in Apple Trees (Malus pumila Mill) and Bioaccumulation in Fruits' by Bai-Ye Sun, Shi- Hong Kan, Yan-Zong Zhang, Jun Wu, Shi-Huai Deng, Chun-Sheng Liu and Gang Yang, published online on January 15, 2010 in Wiley InterScience (www.interscience.wiley.com; DOI: 10.1002/tox.20565), has been retracted by agreement between the authors, the journal Editor in Chief, Dr. Paul Tchounwou, and Wiley Periodicals, Inc. The retraction has been agreed at the request of the authors due to overlap with 'Copper Toxicity and Bioaccumulation in Chinese Cabbage (Brassica pekinensis Rupr.)' by Zhi-Ting Xiong and Hai Wang, published in Environmental Toxicology, Volume 20, pages 188-194, 2005.

  12. On-call x-rays made easy AN Au-Yong On-call x-rays made easy , Amy Au-Yong and Nigel Broderick Churchill Livingstone Elsevier £21.99 304pp 9780702034459 0702034452 [Formula: see text].

    Science.gov (United States)

    2011-02-10

    DesigneD for clinicians involved in the management of acutely ill patients, this book enables them to recognise quickly the appearance of life-threatening conditions. It also concentrates on the interpretation of plain chest and abdominal images.

  13. 實徵研究/Information Literacy in the Workplace: A Cross-cultural Perspective/Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Yuhfen Diana Wu Yuhfen Diana Wu

    2012-04-01

    Full Text Available This cross-cultural study has two main purposes: to investigate how information literacy is perceived in the workplace and to discover how employees obtain information to carry out their jobs in an effective and timely fashion. This project applies a mix of research methods, including site visits, interviews, and a survey. More than 120 participants from forty companies were involved in this study. They were from a wide variety of industries in Taiwan and Silicon Valley, in Northern California, where many companies base offices or operations from around the world. Major obstacles in conducting cross-continent research are cost, time demands, scheduling, and adaptation to local culture. In this global economy, cross-cultural and cross-border research will help educators, such as librarians, understand the complexity of skills expected in the workplace. Much has been written on information literacy, yet very few can relate how information literacy is applied in the workplace. This primary study sheds some light to help academic librarians reposition themselves as researchers-educators integral to student success. 本論文為一跨文化性的研究,具有兩個主要目的:一是探討在職場中對於資訊素養的認知;二是探討員工如何及時有效的獲取和應用資訊來執行自己的任務。本研究採用混合式研究方法,包括實地考察、訪談和問卷調查。研究對象來自北加州矽谷和臺灣40家企業的120多名員工,他們分別從事不同行業。其中許多世界級的跨國企業選擇矽谷或臺灣作為公司總部或世界營運樞紐。進行跨洲研究的主要阻礙包括經費、時間、行程安排與適應當地的文化。跨文化和跨國界的研究將有助於教育工作者,如圖書館員,了解職場上所需技能的複雜性。目前已出版許多關於資訊素養的文獻,僅少涉及職場上資訊素養的應用。由於學術圖書館員在學生的學習過程中扮演不可或缺的角色,此初步研究,可幫助學術圖書館員重新為自己定位。 頁次:84-104

  14. A computational exploration of the McCoy-Tracy-Wu solutions of the third Painlevé equation

    Science.gov (United States)

    Fasondini, Marco; Fornberg, Bengt; Weideman, J. A. C.

    2018-01-01

    The method recently developed by the authors for the computation of the multivalued Painlevé transcendents on their Riemann surfaces (Fasondini et al., 2017) is used to explore families of solutions to the third Painlevé equation that were identified by McCoy et al. (1977) and which contain a pole-free sector. Limiting cases, in which the solutions are singular functions of the parameters, are also investigated and it is shown that a particular set of limiting solutions is expressible in terms of special functions. Solutions that are single-valued, logarithmically (infinitely) branched and algebraically branched, with any number of distinct sheets, are encountered. The algebraically branched solutions have multiple pole-free sectors on their Riemann surfaces that are accounted for by using asymptotic formulae and Bäcklund transformations.

  15. Determination and pharmacokinetic properties of arsenic speciation in Xiao-Er-Zhi-Bao-Wan by high-performance liquid chromatography with inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Han, Xu; Luo, Jiaoyang; Zhou, Wenju; Yang, Shihai; Yang, Meihua

    2016-10-01

    A method of high performance liquid chromatography with a Hamilton PRP-X100 ion-exchange column (250 × 4.1 mm id, 10 μm) coupled to inductively coupled plasma mass spectrometry was employed to generate a full concentration-time profile of arsenic speciation after oral administration. The results exhibited good linearity and revealed that, in the pills, the average arsenic concentration was 10105.4 ± 380.7 mg/kg, and in the water extraction solution, the inorganic As(III) and As(V) concentrations were 220.1 ± 12.6 and 45.5 ± 2.3 mg/kg, respectively. No trace of monomethyl arsenic acid was detected in any of the plasma samples. We then successfully applied the established methodology to examine the pharmacokinetics of arsenic speciation. The resulting data revealed that, after oral administration in rats, the plasma concentration of each arsenic species reached C max shortly after initial dosing, and that the distribution and elimination of As(V) was faster than that of As(III) and dimethyl arsenic acid. Additionally, the t 1/2 values of As(V), As(III), and dimethyl arsenic acid were 3.4 ± 1.6, 14.3 ± 4.0, and 19.9 ± 1.6 h, respectively. This study provides references for the determination of arsenic speciation in mineral-containing medicines and could serve as a useful tool in measuring the true toxicity in traditional medicines that contain them. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. A Chinese medicine warm compress (Wen Jing Zhi Tong Fang), combined with WHO 3-step analgesic ladder treatment for cancer pain relief: A comparative randomized trial.

    Science.gov (United States)

    Cai, Peiling; Li, Liuning; Hong, Hongxi; Zhang, Liwen; He, Chunxia; Chai, Xiaoshu; Liu, Bai; Chen, Zhijian

    2018-03-01

    This study aimed to assess the effectiveness of Chinese medicine warm compress (CMWC) on back meridians in relieving cancer pain, reducing adjuvant analgesic doses and adverse reactions, and improving the quality of life (QOL). A total of 62 patients (age range 39-82 years) diagnosed with a malignant tumor and suffering from cancer-related pain were randomly divided into a treatment group (group A) and a control group (group B) (n = 31 for each). The patients in both groups were administered appropriate drugs for 2 cycles of 7-day treatments according to the World Health Organization (WHO) 3-step ladder for cancer pain relief in adults. In addition, a CMWC was given to patients in group A. Pain relief was assessed using the visual analogue scale (VAS) at various time points before and after interventions in each group. Alteration of analgesic doses, adverse reactions, performance status (PS), and QOL were evaluated and any differences between groups A and B evaluated. VAS scores at various time points after treatment were significantly decreased compared with the baseline level in group A. Overall response rate was significantly improved in group A compared with group B (70.97% vs 29.03%, P pain relief efficacy in various locations were found in group A after treatment vs before treatment (P pain with reduced doses, less adverse reactions, and improved QOL.

  17. Feng xian tai du yu jiao yu he zhi ye xuan ze xing wei: yi ge shi yan fang fa de yan jiu an li

    NARCIS (Netherlands)

    Ding, X.; Sun, Y.; Hartog, J.

    2009-01-01

    An experimental study on risk attitude and choice behavior of education and career This paper introduces a research on risk attitude and choice behavior of education and career. Using the experimental methods, this study focuses on testing the reliability and validity of risk attitude measurement.

  18. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi)

    International Nuclear Information System (INIS)

    Wang, Xin-Xin; Lv, Xia; Li, Shi-Yang; Hou, Jie; Ning, Jing; Wang, Jia-Yue; Cao, Yun-Feng; Ge, Guang-Bo; Guo, Bin; Yang, Ling

    2015-01-01

    As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the mechanism in FP-associated toxicity has not been well investigated yet. This study aimed to investigate the inhibitory effects of FP extract and its major constituents against human UDP-glucuronosyltransferase 1A1 (UGT1A1), the key enzyme responsible for metabolic elimination of bilirubin. To this end, N-(3-carboxy propyl)-4-hydroxy-1,8-naphthalimide (NCHN), a newly developed specific fluorescent probe for UGT1A1, was used to evaluate the inhibitory effects of FP extract or its fractions in human liver microsomes (HLM), while LC-UV fingerprint and UGT1A1 inhibition profile were combined to identity and characterize the naturally occurring inhibitors of UGT1A1 in FP. Our results demonstrated that both the extract of FP and five major components of FP displayed evident inhibitory effects on UGT1A1 in HLM. Among these five identified naturally occurring inhibitors, bavachin and corylifol A were found to be strong inhibitors of UGT1A1 with the inhibition kinetic parameters (K i ) values lower than 1 μM, while neobavaisoflavone, isobavachalcone, and bavachinin displayed moderate inhibitory effects against UGT1A1 in HLM, with the K i values ranging from 1.61 to 9.86 μM. These findings suggested that FP contains natural compounds with potent inhibitory effects against human UGT1A1, which may be one of the important reasons for triggering FP-associated toxicity, including elevated bilirubin levels and liver injury. - Graphical abstract: LC-UV fingerprint and UGT1A1 inhibition profiles were combined to identity and characterize the natural inhibitors of UGT1A1 in F. psoraleae for the first time. Five major components in F. psoraleae were identified as strong inhibitors against UGT1A1 in human liver microsomes, with the K i values ranging from 1.18–9.86 μM. - Highlights: • A method for rapid identification of UGT1A1 inhibitors from herbals was developed. • Fructus psoraleae (FP) extract displayed strong inhibitory effects on UGT1A1. • Five UGT1A1 inhibitory constituents in FP were identified for the first time. • The inhibition mechanism and the inhibition constant were well-characterized.

  19. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xin-Xin [Liaoning Medical University, Jinzhou, Liaoning (China); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Lv, Xia; Li, Shi-Yang [Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Hou, Jie [Dalian Medical University, Dalian 116044 (China); Ning, Jing [Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Dalian Medical University, Dalian 116044 (China); Wang, Jia-Yue [Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Cao, Yun-Feng [Liaoning Medical University, Jinzhou, Liaoning (China); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Ge, Guang-Bo, E-mail: geguangbo@dicp.ac.cn [Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Guo, Bin, E-mail: jyguobin@126.com [Liaoning Medical University, Jinzhou, Liaoning (China); Yang, Ling [Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Jiangxi University of Traditional Chinese Medicine, Nanchang 330006 (China)

    2015-11-15

    As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the mechanism in FP-associated toxicity has not been well investigated yet. This study aimed to investigate the inhibitory effects of FP extract and its major constituents against human UDP-glucuronosyltransferase 1A1 (UGT1A1), the key enzyme responsible for metabolic elimination of bilirubin. To this end, N-(3-carboxy propyl)-4-hydroxy-1,8-naphthalimide (NCHN), a newly developed specific fluorescent probe for UGT1A1, was used to evaluate the inhibitory effects of FP extract or its fractions in human liver microsomes (HLM), while LC-UV fingerprint and UGT1A1 inhibition profile were combined to identity and characterize the naturally occurring inhibitors of UGT1A1 in FP. Our results demonstrated that both the extract of FP and five major components of FP displayed evident inhibitory effects on UGT1A1 in HLM. Among these five identified naturally occurring inhibitors, bavachin and corylifol A were found to be strong inhibitors of UGT1A1 with the inhibition kinetic parameters (K{sub i}) values lower than 1 μM, while neobavaisoflavone, isobavachalcone, and bavachinin displayed moderate inhibitory effects against UGT1A1 in HLM, with the K{sub i} values ranging from 1.61 to 9.86 μM. These findings suggested that FP contains natural compounds with potent inhibitory effects against human UGT1A1, which may be one of the important reasons for triggering FP-associated toxicity, including elevated bilirubin levels and liver injury. - Graphical abstract: LC-UV fingerprint and UGT1A1 inhibition profiles were combined to identity and characterize the natural inhibitors of UGT1A1 in F. psoraleae for the first time. Five major components in F. psoraleae were identified as strong inhibitors against UGT1A1 in human liver microsomes, with the K{sub i} values ranging from 1.18–9.86 μM. - Highlights: • A method for rapid identification of UGT1A1 inhibitors from herbals was developed. • Fructus psoraleae (FP) extract displayed strong inhibitory effects on UGT1A1. • Five UGT1A1 inhibitory constituents in FP were identified for the first time. • The inhibition mechanism and the inhibition constant were well-characterized.

  20. Research progress on criteria for discontinuation of EGFR inhibitor therapy

    Directory of Open Access Journals (Sweden)

    Zhuang HQ

    2012-10-01

    Full Text Available Hong-qing Zhuang, Zhi-yong Yuan, Jun Wang, Ping Wang, Lu-jun Zhao, Bai-lin ZhangDepartment of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, People's Republic of ChinaAbstract: The clinical success of the epidermal growth factor receptor (EGFR tyrosine kinase inhibitors (TKI as therapeutic agents has prompted great interest in their further development and clinical testing for a wide variety of malignancies. However, most studies have focused on the efficacy of TKI, and few studies have been done on the criteria for their discontinuation. The current standard for drug discontinuation is “until progression”, based on change in tumor size. However, tumor size is not related to the gene expression which determines the efficacy of TKI in the final analysis, and it is also difficult to make a thorough and correct prediction based on tumor size when the TKI is discontinued. Nevertheless, clinical evaluation of the criteria for TKI discontinuation is still in its early days. Some promising findings have started to emerge. With the improving knowledge of EGFR and its inhibitors, it is expected that the criteria for discontinuation of EGFR inhibitor therapy will become clearer.Keywords: epidermal growth factor receptor, drug discontinuation, acquired drug-resistance

  1. Projects of Earth Sciences Supported by National Natural Science Foundation of China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    and Chaotic Dynamics of Urban Systems\tCHEN Yan-guang 40071036\tDriving Force for Formation of Spatial Pattern of Natural Pinus Sylvestris var. Mongolica Forest in Eastern Inner Mongolia\tWANG Xiao-ke 40071037\tStudy on the Model of Two-core Structure in the Regional Development\tLU Yu-qi 40071038\tThe Agricultural Development and Its Effect on the Environment of the Xiliao River Valley during the Liao-Jin Period\tHAN Mao-li 40071039\tStudy on the Mechanism of Agricultural Sustainable Development and the Optimization of Industrial Structure in Bashang Plateau\tMA Li 40071040\tStudy of Forest Changes and Soil Erosion on the Upper Reaches of Yangtze River in Last 2000 Years\tLAN Yong 40071041\tThe Spatial Approach of Ecological Optimizing of City Landscape and Its Practice\tLI Gui-cai 40071042\tA Study on the Formation, Change and Sustainable Development of the Old Industrial Areas - A Case Study of Northeastern Region in China\tLI Guo-ping 40071043\tIntegration and Systematization of Mathematic Models for Soil and Water Resources Study in a Basin and Its Application\tZENG Zhi-yuan 40071044\tMonitoring and Modeling of the Eco-hydrological Processes in a Small Watershed in Yingtan, Jiangxi\tZHANG Bin 40071045\tSpatio-temporal Variation of Reconstructed Soil and Its Amelioration in Coal Mines\tHU Zhen-qi 40071046\tIn-situ Electrochemical Monitoring of Nutrients Leaching Loss in Red Soils after Input of Acid Deposition\tJIANG Xin 40071047\tThe Mechanisms of Nitrogen Loss Reduction by the Ammonia Inhibition Films in Paddy Soil\tYIN Bin 40071048\tComposition and Properties of Cutans in Several Soils and Forms and Transformation of Some Elements\tLIU Fan 40071049\tTwo-phase Reactions: A New Study on the Mechanisms of the Interactions of Humic Acids with Metal Ions\tWEI Shi-qiang 40071050\tStudies on Mechanisms of Bioremediation of Heavy Metal Contaminated Soil by Arbuacular Mycorrhiza\tLI Xiao-lin 40071051\tThe Reactions Between Multi-Nutrient Fertilizers and Soils and Their

  2. Manicômio em circuito: os percursos dos jovens e a internação psiquiátrica The psychiatric hospital circuit: the trajectories of yong people prior to psychiatric hospitalization

    Directory of Open Access Journals (Sweden)

    Andrea Cristina Coelho Scisleski

    2008-02-01

    Full Text Available Este artigo analisa a internação psiquiátrica de jovens, tomando-a não a partir de uma perspectiva psicopatológica individual, mas de uma dimensão subjetivo-social com base nos percursos desses jovens até a internação. O estudo foi realizado no Centro Integrado de Atenção Psicossocial para crianças e adolescentes do Hospital Psiquiátrico São Pedro, na cidade de Porto Alegre, Rio Grande do Sul, Brasil, por meio de oficinas com os jovens que estavam em atendimento na internação deste serviço. Percebeu-se uma recorrência que marca o percurso desses jovens e expressa um determinado modo de funcionamento da rede de atenção até a internação, acarretando na produção de um certo perfil desses jovens: pobreza sócio-econômica, baixa escolaridade e uso de drogas. Outro aspecto importante é o papel da ordem judicial nos encaminhamentos à internação, que obedece tanto a uma lógica de punição aos jovens e aos serviços, como também, paradoxalmente, constitui-se numa estratégia de acesso aos serviços de saúde.This article analyzes psychiatric hospitalization of young patients from a contemporary social-subjective (rather than a psychopathological perspective, following the trajectory of these youth prior to their admission. The study was conducted at the Center for Comprehensive Psychosocial Care for Children and Adolescents, São Pedro Psychiatric Hospital, in the city of Porto Alegre, Rio Grande do Sul State, Brazil. Recurrent traits in the trajectory of these youth expressed how the health care network functioned with them prior to their hospitalization, with a consistent pattern of socioeconomic deprivation, low schooling, and drug use. Another key aspect was the role of the court system in referring them for hospitalization, adhering to a kind of logic that punished both the youth and the services and paradoxically formed a strategy for access to health services.

  3. JiaZhang Dui ErTong FaZhan TongBan GuanXi De ZuoYong (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    Science.gov (United States)

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  4. 圖書館事業與交流/The Relationship of Leadership Development and Learning Organization Dimensions/Connie K. Haley, Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Connie K. Haley, Yuhfen Diana Wu Connie K. Haley, Yuhfen Diana Wu

    2011-10-01

    Full Text Available This research examined the relationship among learning organization dimensions, leadership development, employee development, and their interactions with two demographic variables (gender and ethnicity in the context of libraries. The researchers conducted a multivariate analysis of the variance to assess the differences by leadership training groups (low training hours vs. high training hours, or by gender; and by workplace training groups (low vs. high, or by ethnicity (white vs. all others on a linear combination of the seven dimensions of the learning organization. A conclusive summary is provided along with contributive discussion. Implications and contributions to librarians are discussed in addition to future research recommendations. Also included are conclusive final thoughts accompanied by the limitations of this research. 本研究旨在探討美國圖書館界學習型組織,領導智能與員工發展之間的關系,以及它們與兩項人口變量(性別、種族)的相互作用。作者採用線性組合研究了學習型組織的七個範疇,並且使用多變量變異數分析方法來評估領導智能培訓組的差異(培訓時數多寡對比),在職培訓組的差異(培訓時數多寡對比),及種族的差異(白人或其他族裔對比)。除了討論未來研究方向的建議,作者並提供人力資源發展工作者和圖書館員一些啟示。研究最後提出作者的想法及本研究的侷限性。 頁次:146-165

  5. Impacts of land use change scenarios on hydrology and land use patterns in the Wu-Tu watershed in Northern Taiwan

    NARCIS (Netherlands)

    Lin Yu-Pin,; Hong Nien-Ming,; Wu Pei-Jung,; Wu Chen-Fa,; Verburg, P.H.

    2007-01-01

    Developing an approach for simulating and assessing land use changes and their effects on land use patterns and hydrological processes at the watershed level is essential in land use and water resource planning and management. This study provided a novel approach that combines a land use change

  6. The Review on Leveraging Success of Young Scholars in Business Discipline edited by Maciej Mitręga, CeDeWu, Warszawa 2014

    Directory of Open Access Journals (Sweden)

    Peter Kovacs

    2017-04-01

    Full Text Available The study aims to give a comprehensive review of young business scholars in the Visegrad countries (Poland, the Czech Republic, Slovakia and Hungary, describing their scientific performance, prospects and possibilities. The study provides a detailed analysis of the specific situation of the Visegrad countries through examining young scholars facing the challenge of 'publish or perish' in a changing academic world.(fragment of text

  7. A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation

    Directory of Open Access Journals (Sweden)

    Shi HS

    2012-05-01

    Full Text Available Hua-shan Shi1,* Xiang Gao,1,3,* Dan Li,1,* Qiong-wen Zhang,1 Yong-sheng Wang,2 Yu Zheng,1 Lu-Lu Cai,1 Ren-ming Zhong,2 Ao Rui,1 Zhi-yong Li,1 Hao Zheng,1 Xian-cheng Chen,1 Li-juan Chen,11State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China; 2State Key Laboratory of Biotherapy and Department of Thoracic Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of China; 3Deparment of Pathophysiology, College of Preclinical and Forensic Medical Sciences, Sichuan University, Chengdu, People's Republic of China*These authors contributed equally to this workAbstract: Radiation pneumonitis (RP is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2 model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively

  8. Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer

    Directory of Open Access Journals (Sweden)

    Wang BL

    2013-09-01

    Full Text Available Bi-Lan Wang,1,* Yong-mei Shen,1,3,* Qiong-wen Zhang,1,* Yu-li Li,1 Min Luo,1 Ze Liu,1,2 Yan Li,1 Zhi-yong Qian,1 Xiang Gao,1 Hua-shan Shi1,2 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, 2State Key Laboratory of Biotherapy and Department of Head and Neck Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, 3Sichuang Haoyisheng Pharmacy, Chengdu, People’s Republic of China *These authors contributed equally to this work Abstract: Systemic administration of chemotherapy for cancer often has toxic side effects, limiting the doses that can be used in its treatment. In this study, we developed methoxy poly(ethylene glycol-poly(caprolactone (MPEG-PCL micelles loaded with curcumin and doxorubicin (Cur-Dox/MPEG-PCL that were tolerated by recipient mice and had enhanced antitumor effects and fewer side effects. It was shown that these Cur-Dox/MPEG-PCL micelles could release curcumin and doxorubicin slowly in vitro. The long circulation time of MPEG-PCL micelles and the slow rate of release of curcumin and doxorubicin in vivo may help to maintain plasma concentrations of active drug. We also demonstrated that Cur-Dox/MPEG-PCL had improved antitumor effects both in vivo and in vitro. The mechanism by which Cur-Dox/MPEG-PCL micelles inhibit lung cancer might involve increased apoptosis of tumor cells and inhibition of tumor angiogenesis. We found advantages using Cur-Dox/MPEG-PCL micelles in the treatment of cancer, with Cur-Dox/MPEG-PCL achieving better inhibition of LL/2 lung cancer growth in vivo and in vitro. Our study indicates that Cur-Dox/MPEG-PCL micelles may be an effective treatment strategy for cancer in the future. Keywords: methoxy poly(ethylene glycol, poly(caprolactone, curcumin, doxorubicin, micelles, cancer, treatment

  9. Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

    Directory of Open Access Journals (Sweden)

    Shi F

    2012-04-01

    Full Text Available Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaAbstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs for the oral delivery of frankincense and myrrh essential oils (FMO. Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP, and drug encapsulation efficiency (EE were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM. The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC and X-ray diffraction (XRD. In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of -16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.Keywords: solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicine

  10. Gene therapy for C-26 colon cancer using heparin-polyethyleneimine nanoparticle-mediated survivin T34A

    Directory of Open Access Journals (Sweden)

    Zhang L

    2011-10-01

    Full Text Available Ling Zhang1,*, Xiang Gao1,2,*, Ke Men1, BiLan Wang1, Shuang Zhang1, Jinfeng Qiu1, Meijuan Huang1, MaLing Gou1, Ning Huang2, ZhiYong Qian1, Xia Zhao1, YuQuan Wei11State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, 2Department of Pathophysiology, College of Preclinical and Forensic Medical Sciences, Sichuan University, Chengdu, People’s Republic of China*These authors contributed equally to this workBackground: Gene therapy provides a novel method for the prevention and treatment of cancer, but the clinical application of gene therapy is restricted, mainly because of the absence of an efficient and safe gene delivery system. Recently, we developed a novel nonviral gene carrier, ie, heparin-polyethyleneimine (HPEI nanoparticles for this purpose.Methods and results: HPEI nanoparticles were used to deliver plasmid-expressing mouse survivin-T34A (ms-T34A to treat C-26 carcinoma in vitro and in vivo. According to the in vitro studies, HPEI nanoparticles could efficiently transfect the pGFP report gene into C-26 cells, with a transfection efficiency of 30.5% ± 2%. Moreover, HPEI nanoparticle-mediated ms-T34A could efficiently inhibit the proliferation of C-26 cells by induction of apoptosis in vitro. Based on the in vivo studies, HPEI nanoparticles could transfect the Lac-Z report gene into C-26 cells in vivo. Intratumoral injection of HPEI nanoparticle-mediated ms-T34A significantly inhibited growth of subcutaneous C-26 carcinoma in vivo by induction of apoptosis and inhibition of angiogenesis.Conclusion: This research suggests that HPEI nanoparticle-mediated ms-T34A may have a promising role in C-26 colon carcinoma therapy.Keywords: gene therapy, mouse survivin-T34A, colon cancer, polyethyleneimine, nanoparticles, cancer therapy

  11. The role and significance of Luo Zhiyuan's Shu yi hui bian in the history of plague in Lingnan (south of the five ridges).

    Science.gov (United States)

    Li, H; Lai, W

    1999-04-01

    Being the earliest monograph on plague in China, Luo Zhiyuan's Shu yi hui bian, not included in the National Catalogue of TCM Books, include the following contents: personal idea on the etiology of plague; Luo's friend Wu Xuanchang' unpublished Shu yu zhi fa on the treatment and manifestations of plague; Luo's specific recipe for plague based on medified Wang Qingren's Jie du huo xue decoction based on Wang Qingrens yi lin gai cuo; therapy for critical cases; many therapies applied on Lingnan, including experimental recipes, external therapy, preventive methods, and preventing recurrence methods; Luo's special administrating methods, including persisting day-and-night method, immediate persisting method, single-dose persisting method, and double-dose persisting method. He also gave several cured case records. His book, featuring unique idea with good effect, was repeatedly printed and extensively distributed, exerting influence, more or less, on the plague monographs of later ages, and occupying important position in the history of plague on Lingnan and the whole country as well. His idea of "that poisons and static blood" in pathogenesis and therapeutic principle of antitoxicity and activating blood is coincided with the results of present day clinical and laboratory studies. His administration of medicines is heuristic to the therapy of critical cases with Chinese medicaments and to the recognition of pathogenesis, etiology, and treatment of modern plague as well as other diseases of similar etiology and pathognesis and is worth of further study.

  12. A case of 18p deletion syndrome after blepharoplasty

    Directory of Open Access Journals (Sweden)

    Xu LJ

    2017-01-01

    Full Text Available Li-juan Xu,1 Lv-xian Wu,2 Qing Yuan,3 Zhi-gang Lv,1 Xue-yan Jiang2 1Department of Opthalmology, 2Department of Pediatrics, 3Department of Clinical Laboratory, Jinhua Central Hospital, Jinhua, Zhejiang, People’s Republic of China Objective: The deletion of the short arm of chromosome 18 is thought to be one of the rare chromosomal aberrations. Here, we report a case to review this disease.Case report: The proband is a five-and-a-half-year-old girl who has had phenotypes manifested mainly by ptosis, broad face, broad neck with low posterior hairline, mental retardation, short stature, and other malformations. Chromosomal analysis for her mother showed a normal karyotype. Her father and younger brother were phenotypically normal.Result: Phenotypical features were quite similar throughout other cases and in accordance with the usual phenotype of del(18p suggested within the same cases and among the del(18p cases described. She underwent blepharoplasty, which improved her appearance.Conclusion: 18p deletion syndrome is diagnosed by gene analysis. Plastic surgeries for improving the appearance might be an option for these patients. Keywords: chromosome, deletion, blepharoplasty

  13. Several Common Grounds of Liu Zhi-ji and Zhang Xue-cheng in Their Historical Criticism%刘知幾与章学诚史学批评理论中的几个共通面向

    Institute of Scientific and Technical Information of China (English)

    张泓林; 毕兵

    2014-01-01

    Liu Zhiji’ s General History and Zhang Xuecheng ’ s General Principles of Literature and History born several common grounds in historical philosophy such as the relationship between history and literature , the principles and the methods of historical criticism and the self-cultivation of historians .They were particularly complementary and rever-berant in terms of recording the truth without fear or favor , viewing history dialectically and having an insight into the society and human being , thus pioneering a wide range of topics on the research of history and historical philosophy . Meanwhile , by putting forward concepts from the “three accomplishments of historians” to“historians ’ morality” and the “duty” of historians themselves , they not only provided the standard for the historians themselves , but also provid-ed a reference standard for later historians to continue to reflect and improve their self -cultivation .%章学诚的《文史通义》与刘知幾的《史通》在史文关系、史学批评原则与方法、史家自身修养上的总结达到了史学理论的共通面向,尤其是双方在秉笔直书、辨证史义、论世知人等方面的史学批评理论的互补与融合,为后世史学、史学理论的发展开辟了广阔的研究领域。同时,二人关于“史学三长”到“史德”概念的发展衍变及对史家自身“天职”问题的探讨,不仅为史家自身批评素养理论提供了准绳,更是为后世史家不断反思和提高自身修养提供了参考标准。

  14. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  15. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Science.gov (United States)

    Ahn, Sang-Hyeon

    2009-12-01

    We investigated the formation of Pochonka (Song of the Sky Pacers) and Chonmun yucho (Selected and classified writings on astrology) of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contents of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson's Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson's Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson's Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern) published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts that Choson

  16. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Directory of Open Access Journals (Sweden)

    Sang-Hyeon Ahn

    2009-12-01

    Full Text Available We investigated the formation of Pochonka (Song of the Sky Pacers and Chonmun yucho (Selected and classified writings on astrology of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contnts of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson`s Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson`s Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson`s Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts

  17. Cone-beam computed tomography study of the root and canal morphology of mandibular permanent anterior teeth in a Chongqing population [Corrigendum

    Directory of Open Access Journals (Sweden)

    Yang ZY

    2016-03-01

    Full Text Available Zhengyan Yang, Keke Lu, Fei Wang, Yueheng Li, Zhi ZhouDepartment of Preventive Dentistry, The College of Stomatology, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, People’s Republic of ChinaOn page 19, the author’s names were listed incorrectly as Yang Zhengyan, Lu Keke, Wang Fei, Li Yueheng, Zhou Zhi.The correct names are Zhengyan Yang, Keke Lu, Fei Wang, Yueheng Li, Zhi Zhou.View the original paper here.

  18. Discussion of "Carbon benefits of wolfberry plantation on secondary saline land in Jingtai oasis, Gansu - A case study on application of the CBP model" by Yaolin Wang, Chuanyan Zhao, Quanlin Ma, Yingke Li, Hujia Jing, Tao Sun, Eleanor Milne, Mark Easter, Keith Paustian, Hoi Wen Au Yong, John McDonagh (2015) [Journal of Environmental Management 157, 303-310].

    Science.gov (United States)

    Azarnivand, Ali

    2015-12-01

    Wang et al. (2015) employed driving force-pressure-state-impact-response (DPSIR) framework to provide a robust decision-making structure for carbon emission reduction by use of wolfberry plantation in the Jingtai oasis, China. DPSIR appropriately identified the causes of problem along with adopting the responses to the barriers associated with wolfberry plantation. However, the discusser argues that, the paper could have prepared more viable outcomes, if the authors had used causal network rather than causal chains through the DPSIR framework. Furthermore, they could have quantified the mutual relationship among the relevant factors to provide a detailed economic assessment. With this knowledge in hand, the current discussion letter suggests eDPSIR and meDPSIR to address drawbacks regarding conventional DPSIR framework. Due to proper performance of eDPSIR and meDPSIR, they are recommended as practical tools in the future environmental studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Parental Choice of School, Class Strategies, and Educational Inequality: An Essay Review of "School Choice in China--A Different Tale?" (X. Wu, New York, NY: Routledge, 2014, 168 pp. ISBN 978-0-415-81769-1)

    Science.gov (United States)

    Liu, Shuning; Apple, Michael W.

    2016-01-01

    Given the increasingly global nature of marketized school choice policies, this makes it even more crucial to investigate how the multiple scales, forms, and emphases of school choice in different countries are influenced by particular political, economic, and cultural conditions. While much of the critical research on school choice policies has…

  20. 石头的记忆--吴少雄《惠安女人》舞剧音乐印象%Memory of Stones:Impressions of the Music of Wu Shaoxiong's Dance Drama Women of Huian

    Institute of Scientific and Technical Information of China (English)

    宋瑾

    2004-01-01

    @@ 2003年12月,由文化部主办的第三届全国舞剧观摩演出(比赛)在福州举行.由吴少雄作曲的荣获最佳作曲奖.这是作曲家继1992年(沈阳)第一届全国舞剧观摩演出(比赛)其作品(合作)获得作曲第一名之后,时隔11年再度捧冠.

  1. Russian olive - a suitable target for classical biological control in North America? In: Wu, Yun; Johnson, Tracy; Sing, Sharlene; Raghu, S.; Wheeler, Greg; Pratt, Paul; Warner, Keith; Center, Ted; Goolsby, John; Reardon, Richard, eds

    Science.gov (United States)

    K. Delaney; E. Espeland; A. Norton; S. Sing; K. Keever; J. L. Baker; M. Cristofaro; R. Jashenko; J. Gaskin; U. Schaffner

    2013-01-01

    Projects to develop biological control solutions against invasive plants are midto long-term endeavors that require considerable financial support over several years. Discussions of concerns and potential conflicts of interests often occur when biological control agents are first being proposed for release into the environment. Such late discussion, which in some cases...

  2. Correction: Wentao Wu, et al. Evolution Analysis of the Aux/IAA Gene Family in Plants Shows Dual Origins and Variable Nuclear Localization Signals. Int. J. Mol. Sci. 2017, 18, 2107

    Directory of Open Access Journals (Sweden)

    Wentao Wu

    2018-01-01

    Full Text Available The authors would like to insert some websites and citations in the following sentence, “First, the complete proteomes of these species were downloaded from the Phytozome website (Version 11; Available online: www.phytozome.org” in the “Materials and Methods” section on page 13, paragraph 3.1 of their paper published in the International Journal of Molecular Sciences [1].[...

  3. The Conjugate Addition- Elimination Reaction of Morita-Baylis-Hillman C- Adducts: A Density Functional Theory Study

    KAUST Repository

    Tan, Davin

    2011-12-01

    The Morita-Baylis-Hillman (MBH) reaction is a very versatile synthetic protocol to synthesize various useful compounds containing several functional groups. MBH acetates and carbonates are highly valued compounds as they have good potential to be precursors for organic synthesis reactions due to their ease of modification and synthesis. This thesis utilizes Density Functional Theory (DFT) calculations to understand the mechanism and selectivity of an unexpected tandem conjugate addition-elimination (CA-E) reaction of allylic alkylated Morita-Baylis-Hillman C- adducts. This synthetic protocol was developed by Prof. Zhi-Yong Jiang and co-workers from Henan University, China. The reaction required the use of sub-stoichiometric amounts of an organic or inorganic Brøndst base as a catalyst and was achieved with excellent yields (96%) in neat conditions. TBD gave the highest yield amongst the organocatalysts and Cs2CO3 gave the highest yield amongst all screened bases. A possible mechanistic pathway was proposed and three different energy profiles were modeled using 1,5,7-triaza-bicyclo-[4.4.0]-dec-5-ene (TBD), Cs2CO3 and CO32- as catalysts. All three models were able to explain the experimental observations, revealing both kinetic and thermodynamic factors influencing the selectivity of the CA-E reaction. CO32- model gave the most promising result, revealing a significant energy difference of 17.9 kcal/mol between the transition states of the two differing pathways and an energy difference of 20.9 kcal/mol between the two possible products. Although TBD modeling did not show significant difference in the transition states of the differing pathways, it revealed an unexpected secondary non-covalent electrostatic interaction, involving the electron deficient C atom of the triaza CN3 moiety of the TBD catalyst and the O atom of a neighboring NO2- group in the intermediate. Subsequent modeling using a similar substrate proved the possibility of this non

  4. Clinical applications of somatostatin analogs for growth hormone-secreting pituitary adenomas

    Directory of Open Access Journals (Sweden)

    Wang JW

    2014-01-01

    Full Text Available Ji-wen Wang,1,2 Ying Li,3 Zhi-gang Mao,1,2 Bin Hu,1,2 Xiao-bing Jiang,1,2 Bing-bing Song,4 Xin Wang,4 Yong-hong Zhu,4 Hai-jun Wang1,21Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, 2Key Laboratory of Pituitary Adenoma in Guangdong Province, 3State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 4Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of ChinaAbstract: Excessive growth hormone (GH is usually secreted by GH-secreting pituitary adenomas and causes gigantism in juveniles or acromegaly in adults. The clinical complications involving cardiovascular, respiratory, and metabolic systems lead to elevated morbidity in acromegaly. Control of serum GH and insulin-like growth factor (IGF 1 hypersecretion by surgery or pharmacotherapy can decrease morbidity. Current pharmacotherapy includes somatostatin analogs (SAs and GH receptor antagonist; the former consists of lanreotide Autogel (ATG and octreotide long-acting release (LAR, and the latter refers to pegvisomant. As primary medical therapy, lanreotide ATG and octreotide LAR can be supplied in a long-lasting formulation to achieve biochemical control of GH and IGF-1 by subcutaneous injection every 4–6 weeks. Lanreotide ATG and octreotide LAR provide an effective medical treatment, whether as a primary or secondary therapy, for the treatment of GH-secreting pituitary adenoma; however, to maximize benefits with the least cost, several points should be emphasized before the application of SAs. A comprehensive assessment, especially of the observation of clinical predictors and preselection of SA treatment, should be completed in advance. A treatment process lasting at least 3 months should be implemented to achieve a long-term stable blood concentration. More satisfactory surgical outcomes for noninvasive macroadenomas treated

  5. Preparation and characterization of monomethoxy poly(ethylene glycol-poly(ε-caprolactone micelles for the solubilization and in vivo delivery of luteolin

    Directory of Open Access Journals (Sweden)

    Qiu JF

    2013-08-01

    Full Text Available Jin-Feng Qiu,1 Xiang Gao,1,2 Bi-Lan Wang,1 Xia-Wei Wei,1 Ma-Ling Gou,1 Ke Men,1 Xing-Yu Liu,1 Gang Guo,1 Zhi-Yong Qian,1 Mei-Juan Huang1 1Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Medical School, Sichuan University, Chengdu, People’s Republic of China; 2Medical School and Department of Pathophysiology, College of Preclinical and Forensic Medical Sciences, Sichuan University, Chengdu, People’s Republic of China Abstract: Luteolin (Lu is one of the flavonoids with anticancer activity, but its poor water solubility limits its use clinically. In this work, we used monomethoxy poly(ethylene glycol-poly(ε-caprolactone (MPEG-PCL micelles to encapsulate Lu by a self-assembly method, creating a water-soluble Lu/MPEG-PCL micelle. These micelles had a mean particle size of 38.6 ± 0.6 nm (polydispersity index = 0.16 ± 0.02, encapsulation efficiency of 98.32% ± 1.12%, and drug loading of 3.93% ± 0.25%. Lu/MPEG-PCL micelles could slowly release Lu in vitro. Encapsulation of Lu in MPEG-PCL micelles improved the half-life (t½; 152.25 ± 49.92 versus [vs] 7.16 ± 1.23 minutes, P = 0.007, area under the curve (0–t (2914.05 ± 445.17 vs 502.65 ± 140.12 mg/L/minute, P = 0.001, area under the curve (0–∞ (2989.03 ± 433.22 vs 503.81 ± 141.41 mg/L/minute, P = 0.001, and peak concentration (92.70 ± 11.61 vs 38.98 ± 7.73 mg/L, P = 0.003 of Lu when the drug was intravenously administered at a dose of 30 mg/kg in rats. Also, Lu/MPEG-PCL micelles maintained the cytotoxicity of Lu on 4T1 breast cancer cells (IC50 = 6.4 ± 2.30 µg/mL and C-26 colon carcinoma cells (IC50 = 12.62 ± 2.17 µg/mL in vitro. These data suggested that encapsulation of Lu into MPEG-PCL micelles created an aqueous formulation of Lu with potential anticancer effect. Keywords: luteolin, micelle, MPEG-PCL, cancer therapy

  6. 2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research

    Science.gov (United States)

    2010-01-01

    Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational Biology and Drug Design (IJCBDD) and International Journal of Functional Informatics and Personalized Medicine, the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (ISIBM IJCBS 2009) attracted more than 300 papers and 400 researchers and medical doctors world-wide. It was the only inter/multidisciplinary conference aimed to promote synergistic research and education in bioinformatics, systems biology and intelligent computing. The conference committee was very grateful for the valuable advice and suggestions from honorary chairs, steering committee members and scientific leaders including Dr. Michael S. Waterman (USC, Member of United States National Academy of Sciences), Dr. Chih-Ming Ho (UCLA, Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Wing H. Wong (Stanford, Member of United States National Academy of Sciences), Dr. Ruzena Bajcsy (UC Berkeley, Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Qu Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Andrzej Niemierko (Harvard), Dr. A. Keith Dunker (Indiana), Dr. Brian D. Athey (Michigan), Dr. Weida Tong (FDA, United States Department of Health and Human Services), Dr. Cathy H. Wu (Georgetown), Dr. Dong Xu (Missouri), Drs. Arif Ghafoor and Okan K Ersoy (Purdue), Dr. Mark Borodovsky (Georgia Tech, President of ISIBM), Dr. Hamid R. Arabnia (UGA, Vice-President of ISIBM), and other scientific leaders. The committee presented the 2009 ISIBM Outstanding Achievement Awards to Dr. Joydeep Ghosh (UT

  7. [Safety grade of application of traditional Chinese medicines during pregnancy].

    Science.gov (United States)

    Wang, Yu-Guang; Jin, Rui; Kong, Xiang-Wen; Zhang, Bing

    2016-01-01

    The efficacy and safety of application of traditional Chinese medicines (TCMs) during the pregnancy is a hotspot among scholars. However, the traditional pregnancy contraindication content has certain historical limitations, and cannot meet the needs of the current pregnant women for rational drug use. We need to refine and interpret it with modern medical science. In this paper, we summarized the ancient and modern knowledge about pregnancy contradiction and tried to establish a grading safety system, based on the actual clinical practices and thte medication grading concept of western medicines. Specifically speaking, in this paper, we compared the connotations of forbidden/contradiction and cautious use, and focused on the safe herbs that included in the prescriptions for dietary therapy. Meanwhile, in this paper, we summarized the core content of the famous theories of ″You Gu Wu Yun (pregnancy disease)″ and ″Shuai Qi Da Ban Er Zhi (therapy during pregnancy)″, and studied the dangerous and unknown risk of TCMs during pregnancy. At last, a five-grade safety system of TCMs applied on the pregnant women was established, including forbidden, contraindicated, cautious, uncertain and available medicines. We classified medicines with the embryotoxicity (e.g. teratogenic, mutagenic, ageneisa), the traditional toxicity (e.g. abortion), the fierce herbal property (e.g. removing blood stasis, promoting Qi circulation) and reliable edible medicinal herbs. We also place an ″uncertain″ category based on objective reality. Meanwhile, 33 sample TCMs were preliminarily determined. This paper proposed the preference and ideas for the rational herbal use in pregnancy. Copyright© by the Chinese Pharmaceutical Association.

  8. Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

    Directory of Open Access Journals (Sweden)

    Zhang L

    2017-09-01

    Full Text Available Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang, Chang Yang School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of China Abstract: Nose-to-brain transport can provide an excellent pathway for drugs of the central nervous system. Consequently, how to make full use of this pathway in practical applications has become a focus of drug design. However, many aspects affecting drug delivery from the nose to the brain remain unclear. This study aimed to more deeply investigate the transport of puerarin and to explore the mechanism underlying the influence of compatible drugs on puerarin permeability in a primary cell model simulating the nasal mucosa. In this research, based on rat nasal epithelial cells (RNECs cultured in vitro and cytotoxicity assays, the bidirectional transport of puerarin across RNEC monolayers and the effect of its compatibility with peoniflorin and menthol were analyzed. The apparent permeability coefficient was <1.5×10–6 cm/s, and the efflux ratio of puerarin was <2, indicating that puerarin had poor absorption and that menthol but not peoniflorin significantly improved puerarin transport. Simultaneously, through experiments, such as immunofluorescence staining, transepithelial electrical resistance measurement, rhodamine 123 efflux evaluation, the cell membrane fluorescence recovery after photobleaching test, and ATPase activity determination, the permeability promoting mechanism of menthol was confirmed to be closely related to disruption of the tight junction protein structure, to the P-glycoprotein inhibitory effect, to increased membrane fluidity, and to the promotion of enzyme activity. These results provide reliable data on nasal administration of the studied drugs and lay the foundation for a deeper investigation of the nose–brain pathway and nasal administration. Keywords: Chinese herbal compound

  9. Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography

    Directory of Open Access Journals (Sweden)

    Qiu ZX

    2016-09-01

    Full Text Available Zhi-Xin Qiu,1 Yue Cheng,1 Dan Liu,1 Wei-Ya Wang,2 Xia Wu,2 Wei-Lu Wu,2 Wei-Min Li1,2 1Department of Respiratory Medicine, 2Department of Pathology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Lung nodules are being detected at an increasing rate year by year with high-resolution computed tomography (HRCT being widely used. Ground-glass opacity nodule is one of the special types of pulmonary nodules that is confirmed to be closely associated with early stage of lung cancer. Very little is known about solitary ground-glass opacity nodules (SGGNs. In this study, we analyzed the clinical, pathological, and radiological characteristics of SGGNs on HRCT.Methods: A total of 95 resected SGGNs were evaluated with HRCT scan. The clinical, pathological, and radiological characteristics of these cases were analyzed.Results: Eighty-one adenocarcinoma and 14 benign nodules were observed. The nodules included 12 (15% adenocarcinoma in situ (AIS, 14 (17% minimally invasive adenocarcinoma (MIA, and 55 (68% invasive adenocarcinoma (IA. No patients with recurrence till date have been identified. The positive expression rates of anaplastic lymphoma kinase and ROS-1 (proto-oncogene tyrosine-protein kinase ROS were only 2.5% and 8.6%, respectively. The specificity and accuracy of HRCT of invasive lung adenocarcinoma were 85.2% and 87.4%. The standard uptake values of only two patients determined by 18F-FDG positron emission tomography/computed tomography (PET/CT were above 2.5. The size, density, shape, and pleural tag of nodules were significant factors that differentiated IA from AIS and MIA. Moreover, the size, shape, margin, pleural tag, vascular cluster, bubble-like sign, and air bronchogram of nodules were significant determinants for mixed ground-glass opacity nodules (all P<0.05.Conclusion: We analyzed the clinical, pathological, and radiological characteristics of SGGNs on HRCT and found that the size, density

  10. Study of Cu-doping effects on magnetic properties of Fe-doped ZnO ...

    Indian Academy of Sciences (India)

    Administrator

    To take into account the random distribution of ... and spin–orbit interaction were taken into account. .... Lee H J, Jeong S-Y, Ryong Cho C and Hong Park C 2002 Appl. Phys. Lett. ... Zhang Hua-Wei, Wei Zhi-Ren, Li Zhi-Qiang and Dong Guo-Yi.

  11. Magnetic immunoassay using CdSe/ZnS quantum dots as fluorescent probes to detect the level of DNA methyltransferase 1 in human serum sample

    Directory of Open Access Journals (Sweden)

    Yu F

    2018-01-01

    Full Text Available Fei Yu,1,* Ya-min Xiong,1,* Song-cheng Yu,1 Lei-liang He,1 Shan-shan Niu,1 Yu-ming Wu,1 Jie Liu,1 Ling-bo Qu,2 Li-e Liu,1 Yong-jun Wu1 1College of Public Health, 2College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China *These authors contributed equally to this work Background: DNA methyltransferase 1 (DNMT1, a dominant enzyme responsible for the transfer of a methyl group from the universal methyl donor to the 5-position of cytosine residues in DNA, is essential for mammalian development and closely related to cancer and a variety of age-related chronic diseases. DNMT1 has become a useful biomarker in early disease diagnosis and a potential therapeutic target in cancer therapy and drug development. However, till now, most of the studies on DNA methyltransferase (MTase detection have focused on the prokaryote MTase and its activity.Methods: A magnetic fluorescence-linked immunosorbent assay (FLISA using CdSe/ZnS quantum dots as fluorescent probes was proposed for the rapid and sensitive detection of the DNMT1 level in this study. Key factors that affect the precision and accuracy of the determination of DNMT1 were optimized.Results: Under the optimal conditions, the limit of detection was 0.1 ng/mL, the linear range was 0.1–1,500 ng/mL, the recovery was 91.67%–106.50%, and the relative standard deviations of intra- and inter-assays were respectively 5.45%–11.29% and 7.03%–11.25%. The cross-reactivity rates with DNA methyltransferases 3a and 3b were only 4.0% and 9.4%, respectively. Furthermore, FLISA was successfully used to detect the levels of DNMT1 in human serum samples, and compared with commercial enzyme-linked immunosorbent assay (ELISA kits. The results revealed that there was a good correlation between FLISA and commercial ELISA kits (correlation coefficient r=0.866, p=0.001. The linear scope of FLISA was broader than ELISA, and the measurement time was much shorter

  12. [The Seongho () School's Study of the Ancient Learning () and Its Influence on the Debate about Materia Medica in the Late Joseon Dynasty].

    Science.gov (United States)

    Cho, Sung-San

    2015-08-01

    This study will determine the ways in which the ancient learning (gu xue, ) scholarship of the Seongho School, and its interest in the materia medica (ben cao xue, ) were related during the late Joseon period. The Seongho School centered its studies mainly on classical Chinese texts of the Han (206 BC-AD 220) and pre-Han (?-221 BC) (xian-qin lianghan, ) periods rather than those of the Tang and Song dynasties (618-1279). gu xue scholarship emerged during the Ming dynasty era (1368 -1644) as an alternative to the scholarly trends of the Song dynasty, which were dependent on Zhu Xi's (, 1130-1200) Neo-Confucianism and its interpretation of Han and pre-Han classical Chinese texts. This scholarly trend influenced Korean and Japanese literature, philosophy, and even medicine from the seventeenth through the nineteenth centuries. Focusing on Korean scholarship, we find a great deal of research regarding the influence of gu xue on Korean classical Chinese literature and Confucian philosophy in the late Joseon period; however, no study has examined how this style of scholarship influenced the field of medicine during the same period. This study will investigate how the intellectuals of the Seongho School, who did the most to develop gu xue among Joseon intellectuals, were influenced by this style of scholarship in their study of the materia medica. Jeong Yak-yong (1762-1836), the representative intellectual of the Seongho School, did not focus on complicated metaphysical medical theories, such as the Yin-Yang and Five Elements theory (yin yang wu xing shui, ) or the Five Movements and Six Atmospheres theory (wu yun liu qi shui, ). Instead, his interests lay in the exact diagnoses of diseases and meticulous herbal prescriptions which formed an essential part of the Treatise on Exogenous Febrile Disease (Shang han lun, ) written by Zhang Zhungjing (, 150-219) in the Han dynasty. The Treatise was compatible with the scholarly purpose of gu xue in that they both

  13. Prognostic value of Notch-1 expression in hepatocellular carcinoma: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Wu T

    2015-10-01

    Full Text Available Tao Wu,1 Min Jiao,1 Li Jing,1 Min-Cong Wang,1 Hai-Feng Sun,2 Qing Li,1 Yi-Yang Bai,1 Yong-Chang Wei,1 Ke-Jun Nan,1 Hui Guo1 1Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Oncology, Shaanxi Cancer Hospital, Xi’an, People’s Republic of China Abstract: Association of Notch-1 expression with prognosis of patients with hepatocellular carcinoma (HCC remains controversial. We conducted a meta-analysis to reevaluate the association of Notch-1 expression with clinicopathological characteristics and prognosis of HCC. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure were searched to look for relevant studies. The association between Notch-1 expression and clinicopathological parameters and overall survival (OS was then reassessed using the meta-analysis for odds ratio (OR or hazard ratio (HR and 95% confidence interval (CI. A total of seven studies, including 810 HCC patients, were eligible for the meta-analysis. Our data showed that high Notch-1 expression was able to predict poor OS (HR 1.50, 95% CI 1.17–1.83, P=0.0001. The pooled OR showed that high Notch-1 expression was significantly associated with tumor metastasis (OR 0.37, 95% CI 0.16–0.86, P=0.02 and tumor size >5 cm (OR 0.48, 95% CI 0.26–0.88, P=0.02. In contrast, there was no association between high Notch-1 expression and tumor differentiation, late TNM stage, tumor number, and portal vein invasion of HCC. In conclusion, Notch-1 overexpression might predict poorer survival and more aggressive behavior in patients with HCC. Keywords: hepatocellular carcinoma, Notch-1, prognosis, clinicopathological features, meta-analysis

  14. Proceedings of the 2016 China Cancer Immunotherapy Workshop

    Directory of Open Access Journals (Sweden)

    Bin Xue

    2016-10-01

    Full Text Available Table of contents A1 Proceedings of 2016 China Cancer Immunotherapy Workshop, Beijing, China Bin Xue, Jiaqi Xu, Wenru Song, Zhimin Yang, Ke Liu, Zihai Li A2 Set the stage: fundamental immunology in forty minutes Zihai Li A3 What have we learnt from the anti-PD-1/PD-L1 therapy of advanced human cancer? Lieping Chen A4 Immune checkpoint inhibitors in lung cancer Edward B. Garon A5 Mechanisms of response and resistance to checkpoint inhibitors in melanoma Siwen Hu-Lieskovan A6 Checkpoint inhibitor immunotherapy in lymphoid malignancies Wei Ding A7 Translational research to improve the efficacy of immunotherapy in genitourinary malignancies Chong-Xian Pan A8 Immune checkpoint inhibitors in gastrointestinal malignancies Weijing Sun A9 What’s next beyond PD-1/PDL1? Yong-Jun Liu A10 Cancer vaccines: new insights into the oldest immunotherapy strategy Lei Zheng A11 Bispecific antibodies for cancer immunotherapy Delong Liu A12 Updates on CAR-T immunotherapy Michel Sadelain A13 Adoptive T cell therapy: personalizing cancer treatment Cassian Yee A14 Immune targets and neoantigens for cancer immunotherapy Rongfu Wang A15 Phase I/IIa trial of chimeric antigen receptor modified T cells against CD133 in patients with advanced and metastatic solid tumors Meixia Chen, Yao Wang, Zhiqiang Wu, Hanren Dai, Can Luo, Yang Liu, Chuan Tong, Yelei Guo, Qingming Yang, Weidong Han A16 Cancer immunotherapy biomarkers: progress and issues Lisa H. Butterfield A17 Shaping of immunotherapy response by cancer genomes Timothy A. Chan A18 Unique development consideration for cancer immunotherapy Wenru Song A19 Immunotherapy combination Ruirong Yuan A20 Immunotherapy combination with radiotherapy Bo Lu A21 Cancer immunotherapy: past, present and future Ke Liu A22 Breakthrough therapy designation drug development and approval Max Ning A23 Current European regulation of innovative oncology medicines: opportunities for immunotherapy Harald Enzmann, Heinz Zwierzina

  15. The 2nd International Conference on Water Resource and Environment (WRE 2016

    Directory of Open Access Journals (Sweden)

    Zhouli Liu

    2016-11-01

    Full Text Available Table of contents 01 The eco-toxicological effects of cadmium stress on five ornamental plants Zhouli Liu, Wei Chen, Xingyuan He, Shuai Yu, Weihang Ding 02 Study on the formation and release mechanisms of hydrogen sulfide in Longtan coal mine Jianjun Liu, Yuliang Wu, Kaixiang Fan 03 Coral bleaching in the North Reef of China’s Xisha Islands in 2014 Yuanchao Li, Xinqing Zheng, Shiquan Chen, Haiqun Xie 04 Soil chemical characteristics in a Cunninghamia lanceolata stand suffering from ice-snow damage Jie Li, Zhuomin Wang, Li Xue 05 Diversity of understory vegetation was under a Cunninghamia lanceolata stand suffering from ice-snow damage Zhiyang Lie, Weilong Huang, Tongtong Zhou, Li Xue 06 The effect of water, nitrogen and harvesting time on yield and biomass allocation of Helianthus tuberosus L. Kai Gao, Tiexia Zhu 07 The vertical variation of microbial communities in the sediment of sea cucumber pond Weiteng Mao, Pei Yu, Xinfang Lv, Yunchun Li 08 Indicating significances of alpine plant functional groups to environmental change Peixi Su, Rui Shi 09 Research on the daily CH4 fluxes of soil in summer mangrove community at Yingluogang of Guangxi, China Yong Jiang, Xingbin Chen, Shichu liang 10 Beach protection structures in middle and lower reaches of Yangtze River Junfeng Xu 11 Social responsibility management of large dam project with owner as core: an empirical case in China Jiwei Zhu, Zhao Zhai, Linan Zhou, Yun Le, Li Cao 12 The ecological function value assessment analysis of urban waterfront Jiwei Zhu, Ping Lu, Zhiqian Huang, Bei Zhou 13 Mechanism of diurnal osmotic potential changes and adjustment of three Caragana species in different habitats of the Inner Mongolia Plateau Zhirong Zheng, Shihai Lv, Chaoyang Feng 14 Biodiversity of phytoplankton and environmental influences analysis of Longfeng Wetland, China Nan Song, Yan Liu, Xinxin Lu, Yawen Fan 15 The effect of human activities on culturable soil microbes from Yaoquan Mountain in

  16. Evaluating impact level of different factors in environmental impact assessment for incinerator plants using GM (1, N) model.

    Science.gov (United States)

    Pai, T Y; Chiou, R J; Wen, H H

    2008-01-01

    In this study, the impact levels in environmental impact assessment (EIA) reports of 10 incinerator plants were quantified and discussed. The relationship between the quantified impact levels and the plant scale factors of BeiTou, LiZe, BaLi, LuTsao, RenWu, PingTung, SiJhou and HsinChu were constructed, and the impact levels of the GangShan (GS) and YongKong (YK) plants were predicted using grey model GM (1, N). Finally, the effects of plant scale factors on impact levels were evaluated using grey model GM (1, N) too. According to the predicted results of GM, the relative errors of topography/geology/soil, air quality, hydrology/water quality, solid waste, noise, terrestrial fauna/flora, aquatic fauna/flora and traffic in the GS plant were 17%, 14%, 15%, 17%, 75%, 16%, 13%, and 37%, respectively. The relative errors of the same environmental items in the YK plant were 1%, 18%, 10%, 40%, 37%, 3%, 25% and 33%, respectively. According to GM (1, N), design capacity (DC) and heat value (HV) were the plant scale factors that affected the impact levels significantly in each environmental item, and thus were the most significant plant scale factors. GM (1, N) was effective in predicting the environmental impact and analyzing the reasonableness of the impact. If there is an EIA for a new incinerator plant to be reviewed in the future, the official committee of the Taiwan EPA could review the reasonableness of impact levels in EIA reports quickly.

  17. Deformation analysis and prediction of bank protection structure with river level fluctuations

    Science.gov (United States)

    Hu, Rui; Xing, Yixuan

    2017-04-01

    Bank structure is an important barrier to maintain the safety of the embankment. The deformation of bank protection structure is not only affected by soil pressure caused by the excavation of the riverway, but also by the water pressure caused river water level fluctuations. Thus, it is necessary to establish a coupled soil-water model to analyze the deformation of bank structure. Based on Druck-Prager failure criteria and groundwater seepage theory, a numerical model of bank protection structure with consideration of the pore water pressure of soil mass is established. According to the measured river level data with seasonal fluctuating, numerical analysis of the deformation of bank protection structure is implemented. The simulation results show that the river water level fluctuation has clear influence on the maximum lateral displacement of the pile. Meanwhile, the distribution of plastic zone is related to the depth of groundwater level. Finally, according to the river water level data of the recent ten years, we analyze the deformation of the bank structure under extreme river level. The result shows that, compared with the scenario of extreme high river level, the horizontal displacement of bank protection structure is larger (up to 65mm) under extreme low river level, which is a potential risk to the embankment. Reference Schweiger H F. On the use of drucker-prager failure criteria for earth pressure problems[J]. Computers and Geotechnics, 1994, 16(3): 223-246. DING Yong-chun,CHENG Ze-kun. Numerical study on performance of waterfront excavation[J]. Chinese Journal of Geotechnical Engineering,2013,35(2):515-521. Wu L M, Wang Z Q. Three gorges reservoir water level fluctuation influents on the stability of the slope[J]. Advanced Materials Research. Trans Tech Publications, 2013, 739: 283-286.

  18. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 73; Issue 6. Magnons interaction of spinor Bose–Einstein condensates in an optical lattice. Yong-Qing Liu. Volume 73 Issue 6 ... Author Affiliations. Yong-Qing Liu1. Department of Physics and Electronics, XinZhou Teachers University, XinZhou, 034000, China ...

  19. North Korean Civil-Military Trends: Military-First Politics to a Point

    Science.gov (United States)

    2006-09-01

    to the Great Leader. Yi Yong Mu. The NDC’s impact on the formal leadership lineup was made clear by 2001, when Yi Yong Mu, vice chairman of the NDC...to be restricted, as are career bonds that could come about between officers through sequential appointments to same commands. • First time

  20. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. ZI-JING ZHANG. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ...

  1. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. YONG J IANG. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1255-1261. Molecular dynamics study on the relaxation properties of bilayered graphene with defects · WEI ZHANG JIU-REN YIN PING ZHANG YAN-HUAI DING YONG J IANG.

  2. 面对文字的历史:仪式之"乐"与身体记忆%Another Kind of Memory: In Search of Alternative History Through the Meaning of Yue (Music) in Ritual ( miandui wenzi de iishi: yishi zhi "yue" yu shenti jiyi)

    Institute of Scientific and Technical Information of China (English)

    萧梅

    2006-01-01

    本文立足于民族音乐学实地考察之经验,以及相关领域的理论梳理,着重于任何仪式活动都不可或缺之"乐",探索其中存在的以人的身体的直接感受为媒介的记忆方式和"时间性"体现的可能,及其对于音乐学学科发展的意义.

  3. A Summary of Proceedings and Participant Recommendations from a National Workshop on Institutionalizing Progress in Agricultural Extension and Education in Taiwan (Taichung, Taiwan, April 22-24, 1991) = Cejin Wo Guo Nongye Tuiguang Jiaoyu Xin Tizhi Yantaohui Zhuanji. Zhonghua Minguao Bashi Nian Siyue 22 zhi 24.

    Science.gov (United States)

    Ministry of Education, Taipei (Taiwan).

    These proceedings contain four presentations from a workshop at which leaders in agriculture and education contributed suggestions for developing policies and plans for the new Agricultural Extension Education Graduate Institute (AEEGI) in Taiwan. Introductory materials include a list of members of the planning committee, workshop rationale,…

  4. Wake-up radio systems : design, development, performance evaluation and comparison to conventional medium access control protocols for wireless sensor networks

    OpenAIRE

    Oller i Bosch, Joaquim

    2015-01-01

    During the recent years, the research related to Wake-up Radio (WuR) systems has gained noticeable interest. In WuR systems, a node initiating a communication first sends a Wake-up Call (WuC) by means of its Wake-up Transmitter (WuTx), to the Wake-up Receiver (WuRx) of a remote node to activate it in an on-demand manner. Until the reception of the WuC, the node's MCU and main data transceiver are in sleep mode. Hence, WuR drastically reduce the power required by wireless nodes. This thesis...

  5. Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Jiang Y

    2014-01-01

    Full Text Available Yan Jiang,1,* Zhen-Lin Zhang,2,* Zhong-Lan Zhang,3 Han-Min Zhu,4 Yi-Yong Wu,5 Qun Cheng,4 Feng-Li Wu,5 Xiao-Ping Xing,1 Jian-Li Liu,3 Wei Yu,6 Xun-Wu Meng11Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 2Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 3Department of Gynecology and Obstetrics, General Hospital of the People's Liberation Army, Beijing, 4Department of Geriatrics, Shanghai Huadong Hospital, Shanghai, 5Department of Gynecology and Obstetrics, Beijing Hospital, Ministry of Public Health, Beijing, 6Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China*These authors contributed equally to this workObjective: To evaluate whether the efficacy and safety of menatetrenone for the treatment of osteoporosis is noninferior to alfacalcidol in Chinese postmenopausal women.Method: This multicenter, randomized, double-blinded, double-dummy, noninferiority, positive drug-controlled clinical trial was conducted in five Chinese sites. Eligible Chinese women with postmenopausal osteoporosis (N=236 were randomized to Group M or Group A and received menatetrenone 45 mg/day or alfacalcidol 0.5 µg/day, respectively, for 1 year. Additionally, all patients received calcium 500 mg/day. Posttreatment bone mineral density (BMD, new fracture onsets, and serum osteocalcin (OC and undercarboxylated OC (ucOC levels were compared with the baseline value in patients of both groups.Results: A total of 213 patients (90.3% completed the study. After 1 year of treatment, BMD among patients in Group M significantly increased from baseline by 1.2% and 2.7% at the lumbar spine and trochanter, respectively (P<0.001; and the percentage increase of BMD in Group A was 2

  6. Taxonomic notes on Neoperla (Plecoptera: Perlidae) from Sichuan Province of China with the description of two new species.

    Science.gov (United States)

    Li, Weihai; Wang, Ying; Wang, Rongfeng

    2017-01-17

    Species of the perlid genus Neoperla from Sichuan Province, China are reviewed. Two new species are described, Neoperla caii Li & Wang, sp. nov. and N. emeishana Li & Wang, sp. nov. The new species are compared with related congeners. Available types of several known Neoperla species from Sichuan Province were studied and complementary descriptions or brief taxonomic comments are presented for N. bilineata Wu & Claassen, N. chui Wu & Claassen, N. microtumida Wu & Claassen, N. quadrata Wu & Claassen and N. truncata Wu.

  7. 78 FR 9015 - Osage Negotiated Rulemaking Committee

    Science.gov (United States)

    2013-02-07

    ... 14, 2013, from 8 a.m. to 6 p.m. ADDRESSES: February Meeting: Wah Zha Zhi Cultural Center, 1449 W. Main, Pawhuska, Oklahoma 74056; March Meeting: Osage Casino Event Center, 951 W. 36 Street North, Tulsa...

  8. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Dong Jun Jee1 Tuo Yeong Lee1 Nathaniel Zhi-Wei Leon1. Department of Mathematics, Statistics and Computing, NUS High School of Mathematics and Science, 20 Clementi Avenue 1, Singapore 129957, Republic of Singapore ...

  9. Effects of polysaccharide from Lycium barbarum in alloxan-induced ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-01

    8613170662021. (Zhi et al., 2004; Gan et al., 2004; Zhang et al., 2004). LBP have been recently studied for their physiological and pharmaceutical activities. The purpose of this study was to investigate the effect of LBP in alloxan-induced.

  10. Epigenetic Machinery Regulates Alternative Splicing of Androgen Receptor (AR) Gene in Castration Resistant Prostate Cancer

    Science.gov (United States)

    2017-09-01

    resistant prostate cancer PRINCIPAL INVESTIGATOR: Zhi-Ping Liu CONTRACTING ORGANIZATION: UT Southwestern Medical Center Dallas, TX 75390 REPORT DATE...NUMBER gene in castration-resistant prostate cancer 5b. GRANT NUMBER W81XWH-16-1-0531 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Zhi-Ping Liu 5d...NOTES 14. ABSTRACT Androgen deprivation therapy (ADT) is the primary treatment for metastatic prostate cancer (PCa) since PCa depends on androgen for

  11. PREFACE: The 15th International Conference on X-ray Absorption Fine Structure (XAFS15)

    Science.gov (United States)

    Wu, Z. Y.

    2013-04-01

    Committees and Staff Chair of the Conference Ziyu Wu International Advisory Committee Adam Hitchcock, Canada Adriano Filipponi, Italy Alain Manceau, France Alexander Soldatov, Russia Andrea Di Cicco, Italy Britt Hedman, USA Bruce Bunker, USA Calogero R. Natoli, Italy Christopher T. Chantler, Australia Frank M. F. De Groot, Netherlands Hiroyuki Oyanagi, Japan Ingolf Lindau, USA J. Mustre de Leon, México James E Penner-Hahn, USA Joaquin Garcia Ruiz, Spain John Evans, UK John J. Rehr, USA Kiyotaka Asakura, Japan Majed Chergui, Switzerland Mark Newton, UK Shiqiang Wei, P. R. China Tsun-Kong Sham, Canada Ziyu Wu, P. R. China International Program Committee Antonio Bianconi, Italy Augusto Marcelli, Italy Emad Flear Aziz, Germany Jinghua Guo, USA Joly Yves, France Masaharu Nomura, Japan Maurizio Benfatto, Italy Pieter Glatzel, France Shiqiang Wei, China Tiandou Hu, China Toshihiko Yokoyama, Japan Way-Faung Pong, Taiwan Xinyi Zhang, China Yi Xie, China Yuying Huang, China Zhonghua Wu, China Ziyu Wu, China Local Organizing Committee Bo He Fengchun Hu Haifeng Zhao Jing Zhang Meijuan Yu Qin Yu Shuo Zhang Wangsheng Chu Wei He Wei Xu Wensheng Yan Xiaomei Gong Xing Chen Yang Zou Yi Xia Zheng Jiang Zhi Xie Zhihu Sun Zhiyun Pan Additional Staff Chengxun Liu

  12. Prognostic factors for survival among patients with primary bone sarcomas of small bones

    Directory of Open Access Journals (Sweden)

    Wang Z

    2018-05-01

    Full Text Available Zhan Wang,1,* Shu Li,2,* Yong Li,1 Nong Lin,1 Xin Huang,1 Meng Liu,1 Weibo Pan,1 Xiaobo Yan,1 Lingling Sun,1 Hengyuan, Li,1 Binghao Li,1 Hao Qu,1 Yan Wu,1 Peng Lin,1 Zhaoming Ye1 1Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, Hangzhou, China; 2Key Laboratory of Cancer Prevention and Intervention, Key Laboratory of Molecular Biology in Medical Sciences, National Ministry of Education, Department of Hematology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Institute, Hangzhou, China *These authors contributed equally to this work Background: Primary bone sarcomas of the hands or feet are rare lesions and poorly documented. Moreover, the prognostic determinants of bone sarcomas of the hands or feet have not been reported. Materials and methods: The Surveillance, Epidemiology, and End Results (SEER program database was used to screen patients with bone sarcomas of the hands or feet from 1973 to 2013, with attention paid to chondrosarcoma, Ewing sarcoma, and osteosarcoma. The prognostic values of overall survival (OS and cancer-specific survival (CSS were assessed using Cox proportional hazards regression model with univariate and multivariate analyses. The Kaplan–Meier method was used to obtain OS and CSS curves. Results: A total of 457 cases were selected from the SEER database. Chondrosarcoma was the most common form of lesion in hands or feet or both, followed by Ewing sarcoma and osteosarcoma. The 5- and 10-year OS rates of the entire group were 75.7% and 66.1%, respectively. The 5- and 10-year CSS rates were 78.7% and 73.7%, respectively. Multivariate analysis revealed that age under 40 years, localized stage, low grade, surgical treatment, and first primary tumor were associated with improved OS, and decade of diagnosis, stage, grade, and surgery were independent

  13. Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide nanoparticles for intestinal delivery of exendin-4

    Directory of Open Access Journals (Sweden)

    Wang M

    2013-03-01

    Full Text Available Mengshu Wang,1* Yong Zhang,1* Jiao Feng,1 Tiejun Gu,1 Qingguang Dong,1 Xu Yang,2 Yanan Sun,1 Yongge Wu,1 Yan Chen,1 Wei Kong1 1National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, People’s Republic of China; 2BCHT Biopharm Co, Ltd, Changchun, People’s Republic of China*These authors contributed equally to this workBackground: Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide (CS-PLGA nanoparticles was investigated for intestinal delivery of exendin-4.Methods and results: Nanoparticles were prepared using a modified water–oil–water (w/o/w emulsion solvent-evaporation method, followed by coating with chitosan. The physical properties, particle size, and cell toxicity of the nanoparticles were examined. The cellular uptake mechanism and transmembrane permeability were performed in Madin-Darby canine kidney-cell monolayers. Furthermore, in vivo intraduodenal administration of exendin-4-loaded nanoparticles was carried out in rats. The PLGA nanoparticle coating with chitosan led to a significant change in zeta potential, from negative to positive, accompanied by an increase in particle size of ~30 nm. Increases in both the molecular weight and degree of deacetylation of chitosan resulted in an observable increase in zeta potential but no apparent change in the particle size of ~300 nm. Both unmodified PLGA and chitosan-coated nanoparticles showed only slight cytotoxicity. Use of different temperatures and energy depletion suggested that the cellular uptake of both types of nanoparticles was energy-dependent. Further investigation revealed that the uptake of PLGA nanoparticles occurred via caveolin-mediated endocytosis and that of CS-PLGA nanoparticles involved both macropinocytosis and clathrin-mediated endocytosis

  14. Fludarabine-based versus CHOP-like regimens with or without rituximab in patients with previously untreated indolent lymphoma: a retrospective analysis of safety and efficacy

    Directory of Open Access Journals (Sweden)

    Xu XX

    2013-10-01

    Full Text Available Xiao-xiao Xu,1 Bei Yan,2 Zhen-xing Wang,3 Yong Yu,1 Xiao-xiong Wu,2 Yi-zhuo Zhang11Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, 2Department of Hematology, First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, 3Department of Stomach Oncology, TianJin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of ChinaAbstract: Fludarabine-based regimens and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone-like regimens with or without rituximab are the most common treatment modalities for indolent lymphoma. However, there is no clear evidence to date about which chemotherapy regimen should be the proper initial treatment of indolent lymphoma. More recently, the use of fludarabine has raised concerns due to its high number of toxicities, especially hematological toxicity and infectious complications. The present study aimed to retrospectively evaluate both the efficacy and the potential toxicities of the two main regimens (fludarabine-based and CHOP-like regimens in patients with previously untreated indolent lymphoma. Among a total of 107 patients assessed, 54 patients received fludarabine-based regimens (FLU arm and 53 received CHOP or CHOPE (doxorubicin, cyclophosphamide, vincristine, prednisone, or plus etoposide regimens (CHOP arm. The results demonstrated that fludarabine-based regimens could induce significantly improved progression-free survival (PFS compared with CHOP-like regimens. However, the FLU arm showed overall survival, complete response, and overall response rates similar to those of the CHOP arm. Grade 3–4 neutropenia occurred in 42.6% of the FLU arm and 7.5% of the CHOP arm (P 60 years and presentation of grade 3–4 myelosuppression were the independent factors to infection, and the FLU arm had significantly

  15. Effects of HGF gene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer

    Directory of Open Access Journals (Sweden)

    Chen HY

    2017-02-01

    Full Text Available Hai-Yong Chen,1,2 Yao-Min Chen,3 Jian Wu,1,2 Fu-Chun Yang,1,2 Zhen Lv,1,2 Yi-Gang Qian,1,2 Shu-Sen Zheng1,2 1Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 3Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China Objective: To investigate the correlations of two hepatocyte growth factor (HGF gene polymorphisms (rs5745652 and rs2074725 and their protein expression levels with the efficacy of transhepatic arterial chemotherapeutic embolism (TACE and prognosis in patients with primary liver cancer (PLC. Methods: From March 2011 to June 2012, 109 PLC patients (the case group who chose TACE as primary treatment and 80 healthy people (the control group who had undergone physical examination in The First Affiliated Hospital, Zhejiang University were selected during the same period. Gene polymorphisms of HGF rs5745652 and HGF rs2074725 were detected. Serum HGF level, treating efficacy, survival quality, and 3-year survival rate for PLC patients who received TACE were observed. Results: There were significant differences in genotype and allele frequencies of HGF rs5745652 and HGF rs2074725, between the case and control groups (all P<0.05. Compared with CT+TT genotype of HGF rs5745652, patients carrying CC genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate (all P<0.05. In rs2074725, patients carrying CA+AA genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate compared with patients carrying rs2074725 CC genotype (all P<0.05. Gene polymorphisms of HGF rs5745652 and HGF rs2074725, tumor size, and Barcelona Clinic Liver Cancer stage were independent prognostic factors for PLC (P<0.05. Conclusion: Our

  16. Postoperative radiotherapy for invasive micropapillary carcinoma of the breast: an analysis of Surveillance, Epidemiology, and End Results database

    Directory of Open Access Journals (Sweden)

    Wu SG

    2017-10-01

    Full Text Available San-Gang Wu,1,* Wen-Wen Zhang,2,* Jia-Yuan Sun,2 Feng-Yan Li,2 Yong-Xiong Chen,3 Zhen-Yu He2 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 3Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen, People’s Republic of China *These authors contributed equally to this work Introduction: Invasive micropapillary carcinoma (IMPC of the breast poses a high risk of locoregional recurrence, and postoperative radiotherapy (PORT may be beneficial in IMPC. Hence, we determined the clinical value of PORT in IMPC patients. Patients and methods: We assessed clinicopathological factors extracted from the Surveillance, Epidemiology, and End Results database (2004–2013. Univariate and multivariate Cox proportional hazards regressions were performed to assess the independent prognostic factors on breast cancer-specific survival (BCSS and overall survival (OS. Results: Of the 881 study patients, 444 (50.4% and 437 (49.6% underwent breast-conserving surgery (BCS and mastectomy (MAST, respectively, of whom 357 (80.4% and 153 (35.0% underwent PORT, respectively. Patients with young age, large tumor size, or advanced nodal stage were more likely to undergo MAST and PORT compared with MAST alone. Patients with progesterone receptor-positive disease were more likely to receive BCS and PORT compared with BCS alone. The 5-year BCSS and OS were 95.7% and 90.9%, respectively. On multivariate analyses, tumor size, histological grade, and estrogen receptor status were independent predictors of BCSS and OS. The types of surgical procedures (MAST vs. BCS were not an independent predictor of survival outcomes. Patients who

  17. Using the geometric mean fluorescence intensity index method to measure ZAP-70 expression in patients with chronic lymphocytic leukemia

    Directory of Open Access Journals (Sweden)

    Wu YJ

    2016-02-01

    Full Text Available Yu-Jie Wu, Hui Wang, Jian-Hua Liang, Yi Miao, Lu Liu, Hai-Rong Qiu, Chun Qiao, Rong Wang, Jian-Yong Li Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, People’s Republic of China Abstract: Expression of ζ-chain-associated protein kinase 70 kDa (ZAP-70 in chronic lymphocytic leukemia (CLL is associated with more aggressive disease and can help differentiate CLL from cases expressing mutated or unmutated immunoglobulin heavy chain variable region (IgHV genes. However, standardizing ZAP-70 expression by flow cytometric analysis has proved unsatisfactory. The key point is that ZAP-70 is weakly expressed with a continuous expression pattern rather than a clear discrimination between positive and negative CLL cells, which means that the resulting judgment is subjective. Thus, in this study, we aimed at assessing the reliability and repeatability of ZAP-70 expression using the geometric mean fluorescence intensity (geo MFI index method based on flow cytometry with 256-channel resolution in a series of 402 CLL patients and to compare ZAP-70 with other biological and clinical prognosticators. According to IgHV mutational status, we were able to confirm that the optimal cut-off point for the geo MFI index was 3.5 in the test set. In multivariate analyses that included the major clinical and biological prognostic markers for CLL, the prognostic impact of ZAP-70 expression appeared to have stronger discriminatory power when the geo MFI index method was applied. In addition, we found that ZAP-70-positive patients according to the geo MFI index method had shorter time to first treatment or overall survival (P=0.0002, P=0.0491. This is the first report showing that ZAP-70 expression can be evaluated by a new approach, the geo MFI index, which could be a useful prognostic method as it is more reliable, less subjective, and therefore better associated with improvement of CLL prognostication

  18. Efficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia

    Directory of Open Access Journals (Sweden)

    Chen HF

    2014-09-01

    Full Text Available Hai-Fei Chen,* Bin-Xian Xu, Hong-Shi Shen,* Zheng-Yang Li, Ling-Juan Jin, Jie-Qing Tang, Jing Wang, Jing-Jing Zhu, Long-Mei Qin, Qing-Ya Cui, Yong-Ya Ren, Tian-Qin Wu Department of hematology, 100th hospital of People’s Liberation Army, Suzhou, Jiangsu province, The People’s Republic of China *These authors have contributed equally to this paper Objective: To investigate the clinical characteristics of seronegative hepatitis-associated aplastic anemia (AA (SNHAA and hepatitis B virus (HBV infection complicating AA (HBVAA, and thereby compare the efficacy of immunosuppressive therapy (IST.Methods: An analysis was conducted on the clinical data of ten patients with SNHAA out of 332 cases of AA from our center at AA diagnosis, and on the efficacy of IST. This was compared to 22 cases of HBVAA at AA onset as well as the associated IST outcomes.Results: Nine patients with SNHAA developed severe aplastic anemia, with a median age of 18 years. After IST, six (60% of the SNHAA patients achieved complete remission and two achieved partial remission. The patients with HBVAA had a total response rate of 82.3%. The disease recurred in two HBVAA patients. No statistically significant differences were observed in response rate, mortality, and recurrence rate between both groups. As compared with HBVAA, patients with SNHAA had a shorter interval from the acute episode of hepatitis to AA onset (4 months versus 92 months, P=0.00, a quicker response to IST (2.5 months versus 4.5 months, P=0.018, a lower proportion of bone marrow hematopoietic tissues (20.6% versus 23.6%, P=0.03, and lower white blood cell and absolute neutrophil count (0.8×109/L versus 1.23×109/L and 0.26×109/L versus 0.58×109/L, P=0.026 and P=0.0009, respectively. No significant liver damage or hepatitis B fulminant infection was observed in either group during the follow-up. Conclusion: The prevalence of SNHAA is 3.01%. SNHAA often presents as severe AA and responds to IST quickly

  19. 20(S-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

    Directory of Open Access Journals (Sweden)

    Zhang F

    2015-08-01

    Full Text Available Fei Zhang,* Maolan Li,* Xiangsong Wu,* Yunping Hu, Yang Cao, Xu’an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong,# Jun Gu,# Yingbin Liu#Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work #These authors jointly directed this work Abstract: Gallbladder cancer (GBC, the most frequent malignancy of the biliary tract, is associated with high mortality and extremely poor prognosis. 20(S-ginsenoside Rg3 (20(S-Rg3 is a steroidal saponin with high pharmacological activity. However, the anticancer effect of 20(S-Rg3 in human GBC has not yet been determined. In this study, we primarily found that 20(S-Rg3 exposure suppressed the survival of both NOZ and GBC-SD cell lines in a concentration-dependent manner. Moreover, induction of cellular senescence and G0/G1 arrest by 20(S-Rg3 were accompanied by a large accumulation of p53 and p21 as a result of murine double minute 2 (MDM2 inhibition. 20(S-Rg3 also caused a remarkable increase in apoptosis via the activation of the mitochondrial-mediated intrinsic caspase pathway. Furthermore, intraperitoneal injection of 20(S-Rg3 (20 or 40 mg/kg for 3 weeks markedly inhibited the growth of xenografts in nude mice. Our results demonstrated that 20(S-Rg3 potently inhibited growth and survival of GBC cells both in vitro and in vivo. 20(S-Rg3 attenuated GBC growth probably via activation of the p53 pathway, and subsequent induction of cellular senescence and mitochondrial-dependent apoptosis. Therefore, 20(S-Rg3 may be a potential chemotherapeutic agent for GBC therapy.Keywords: gallbladder cancer, 20(S-ginsenoside Rg3, senescence, apoptosis, p53 pathway

  20. Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Zang JL

    2017-01-01

    Full Text Available Jialan Zang,1–3,* Yong Hu,1,2,* Xiaoyue Xu,1,2 Jie Ni,1,2 Dali Yan,1,2 Siwen Liu,4 Jieyu He,5 Jing Xue,4 Jianzhong Wu,4 Jifeng Feng2 1The Fourth Clinical School of Nanjing Medical University, 2Department of Chemotherapy, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 3Department of Oncology, The First Hospital of Harbin City, Harbin, 4Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital, 5Department of Public Health, Southeast University, Nanjing, People’s Republic of China *These authors contributed equally to this work Aim: This study was designed to investigate the predictive and prognostic values of serum vascular endothelial growth factor (VEGF level in non-small cell lung cancer (NSCLC patients treated with platinum-based chemotherapy. Methods: Patients’ peripheral blood samples were collected prior to chemotherapy and after 1 week of the third cycle of combination chemotherapy. Serum VEGF levels were evaluated through Luminex multiplex technique. Between September 2011 and August 2015, a total of 135 consecutive advanced or recurrent histologically verified NSCLC patients were enrolled in the study. Moreover, all the patients received platinum-based combination chemotherapy as a first-line treatment. Results: No significant associations were found between pretreatment serum VEGF levels and clinical characteristics, such as sex (P=0.0975, age (P=0.2522, stage (P=0.1407, lymph node metastasis (P=0.6409, tumor location (P=0.3520, differentiated degree (P=0.5608, pathological (histological type (P=0.4885, and response to treatment (P=0.9859. The VEGF load per platelet (VEGFPLT levels were not correlated with sex, age, primary tumor site, and pathological type in NSCLC patients (all P>0.05. The median survival time of progression-free survival (PFS was 6.407 and 5.29 months in the low and high groups, respectively, when using 280 pg/mL VEGF level as the cutoff point (P=0.024. Conclusion

  1. Koreade juhid lõid rahu eelduseks käed / Triin Oppi

    Index Scriptorium Estoniae

    Oppi, Triin

    2007-01-01

    Lõuna-Korea president Roh Moo-Hyan ja Põhja-Korea rahvavabariigi juht Kim Yong Il tõotavad ühisavalduses muuta Korea poolsaare tuumavabaks ja edendada kaubavahetust, turismi ja poliitilist läbikäimist

  2. Chemical engineering in the pharmaceutical industry: R&D to manufacturing

    National Research Council Canada - National Science Library

    Ende, David J. am

    2011-01-01

    ... Process R&D Edward L. Paul 73 7 Reaction Kinetics and Characterization Utpal K. Singh and Charles J. Orella 79 vvi CONTENTS 8 Understanding Rate Processes in Catalytic Hydrogenation Reactions Yong...

  3. Categorizing renal oncocytic neoplasms on core needle biopsy: a morphologic and immunophenotypic study of 144 cases with clinical follow-up. Alderman MA, Daignault S, Wolf JS Jr, Palapattu GS, Weizer AZ, Hafez KS, Kunju LP, Wu AJ. Hum Pathol.September 2016;55:1-10.

    Science.gov (United States)

    Kryvenko, Oleksandr N

    2017-06-01

    There is limited literature on renal oncocytic neoplasms diagnosed on core biopsy. All renal oncocytic neoplasm core biopsies from 2006 to 2013 were, retrospectively, reviewed. Morphologic features and an immunohistochemical panel of CK7, c-KIT, and S100A1 were assessed. Concordance with resection diagnosis, statistical analysis including a random forest classification, and follow-up were recorded. The postimmunohistochemical diagnoses of 144 renal oncocytic core biopsies were favor oncocytoma (67%), favor renal cell carcinoma (RCC) (12%), and cannot exclude RCC (21%). Diagnosis was revised following immunohistochemistry in 7% of cases. The most common features for oncocytoma (excluding dense granular cytoplasm) were nested architecture, edematous stroma, binucleation and tubular architecture; the most common features for favor RCC were sheet-like architecture, nuclear pleomorphism, papillary architecture, and prominent cell borders. High nuclear grade, necrosis, extensive papillary architecture, raisinoid nuclei, and frequent mitoses were not seen in oncocytomas. Comparing the pathologist and random forest classification, the overall out-of-bag estimate of classification error dropped from 23% to 13% when favor RCC and cannot exclude RCC was combined into 1 category. Resection was performed in 19% (28 cases) with a 94% concordance (100% of favor RCC biopsies and 90% of cannot exclude RCC biopsies confirmed as RCC; 83% of favor oncocytomas confirmed); ablation in 23%; and surveillance in 46%. Follow-up was available in 92% (median follow-up, 33 months) with no adverse outcomes. Renal oncocytic neoplasms comprise a significant subset (16%) of all core biopsies, and the majority (78%) can be classified as favor oncocytoma or favor RCC. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Commentary on "tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl) nitrosamine as the basis for urothelial cell carcinogenesis." He Z, Kosinska W, Zhao ZL, Wu XR, Guttenplan JB, Department of Basic Science, New York University Dental College, NY, USA.: Mutat Res 2012;742(1-2):92-5 [Epub 2011 Dec 4].

    Science.gov (United States)

    Scherr, Douglas S

    2014-02-01

    Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke. Of the carcinogens tested in mouse chemical carcinogenesis models, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is one that reproducibly causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. However, the basis for such a high-level tissue-specificity has not been explored. Using mutagenesis in lacI (Big Blue™) mice, we show here that BBN is a potent mutagen and it causes high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. After a 2-6-week treatment of 0.05% BBN in the drinking water, mutagenesis in urothelial cells of male and female mice was about two orders of magnitude greater than the spontaneous mutation background. In contrast, mutagenesis in smooth muscle cells of the urinary bladder was about five times lower than in urothelial tissue. No appreciable increase in mutagenesis was observed in kidney, ureter, liver or forestomach. In lacI (Big Blue™) rats, BBN mutagenesis was also elevated in urothelial cells, albeit not nearly as profoundly as in mice. This provides a potential explanation as to why rats are less prone than mice to the formation of aggressive form of bladder cancer induced by BBN. Our results suggest that the propensity to BBN-triggered mutagenesis of urothelial cells underlies its heightened susceptibility to this carcinogen and that mutagenesis induced by BBN represents a novel model for initiation of bladder carcinogenesis. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. The Role of MicroRNAs in Pancreatitis

    Science.gov (United States)

    2015-10-01

    AD______________ AWARD NUMBER: W81XWH-14-1-0469 TITLE: The Role of microRNAs in Pancreatitis PRINCIPAL INVESTIGATOR: Li, Yong RECIPIENT...The Role of MicroRNAs in Pancreatitis 5b. GRANT NUMBER W81XWH-14-1-0469 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Li, Yong 5e...AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Pancreatitis (inflammation of the

  6. Anti-tumor activity of polysaccharides extracted from Senecio ...

    African Journals Online (AJOL)

    *, Bao Zhang, Mingming Han, Xin Jin, Liyuan Sun and Tao Li. Department of ..... Yang J, Li X, Xue Y, Wang N, Liu W. Anti-hepatoma activity and mechanism of corn ... Peng W, Wu JG, Jiang YB, Liu YJ, Sun T, Wu N, Wu CJ. Antitumor activity of ...

  7. Two new genera and three new species of Epipaschiinae Meyrick from China (Lepidoptera, Pyralidae

    Directory of Open Access Journals (Sweden)

    Mingqiang Wang

    2017-12-01

    Full Text Available Two new genera of Epipaschiinae are described. The genus Arcanusa Wang, Chen & Wu, gen. n. is established for Ar. apexiarcanusa Wang, Chen & Wu, sp. n. and Ar. sinuosa (Moore, 1888, comb. n., described in Scopocera Moore, 1888 (junior synonym of Stericta Lederer, 1863. The female genitalia of Ar. sinuosa (Moore, 1888, comb. n. are described for the first time. Androconia Wang, Chen & Wu, gen. n. is erected, including two new species, An. rallusa Wang, Chen & Wu, sp. n. and An. morulusa Wang, Chen & Wu, sp. n. Illustrations of all adults and their genitalia, and a key to the two new genera are provided.

  8. 專論/台灣圖書館史數位圖書館建構之研究/王梅玲;蔡明月;陳志銘;柯雲娥;蔡佳縈;陳勇汀;林怡甄 | A Digital Library Pilot Study on Taiwan Libraries' History / Mei-Ling Wang; Ming-Yueh Tsay; Chih-Ming Chen; Yun-Er Ke; Chia-Ying Tsai; Yong-Ting Chen; Yi-Jen Lin

    Directory of Open Access Journals (Sweden)

    王梅玲、蔡明月、陳志銘、柯雲娥、蔡佳縈、陳勇汀、林怡甄

    2008-04-01

    Full Text Available

    圖書館是保存與詮釋人類文化重要的機構,1990 年代開始,網際網路的進步,促成數位圖書館蓬勃發展,有人預測它就是未來的圖書館,因此,圖書館界與教育界積極參與相關研究。台灣地區歷經日據時期、重建 時期、成長時期及茁壯時期四階段,建設許多圖書館,有其豐富的主題與素材值得發展成為數位圖書館。政治大學圖書資訊與檔案學研究所有鑑於此,提出「『台灣 百無圖書館史』數位圖書館」的構想,並獲得政大「發展國際一流大學及頂尖研究中心計畫」經費支持。本研究計畫目的包括:(1探索以台彎圖書館事業史為主 題的數位圖書館建構模式;(2建構數位圖書館以支援圖書資訊學教育與研究;(3研訂圖書館事業史料文獻的Metadata與數位資料格式;(4將圖 書文獻與文物數位化以建構數位館藏;(5發展數位圖書館系統與技術;(6研發數位圖書館網站的瀏覽與檢索功能;(7探討數位圖書館支援數位學習的模 式。計畫成果共研訂六種 Metadata標準:建置746筆數位化資料;以Dspace系統平台,依據需求設計台灣百年圖書館史系統架構與網站,最後提出結論與建議。

    Libraries are important social institutions that preserve and communicate human culture and knowledge. From the beginning of 1990s, the digital library has grown up rapidly based on the progress of the Internet. Libraries and educational institutions should be actively involved in digital library research and development. The Taiwan libraries’ history can be divided into four stages: Japanese occupation period, reconstruction period, growth period and strong period. In these processes, many events and libraries with rich materials that can be developed into a digital library. Graduate Institute of Library, Information and Archival Studies, National Chengchi University, planned the Digital Library Pilot Study on Taiwan Libraries’ History and got the university support. The pilot study objectives include: (1 exploring the digital library model on Taiwan libraries' history; (2 constructing digital library to support education and research in information and library science; (3 developing Metadata standards of library documents and heritage; (4 digitalizing documents and heritage to build digital collections (5 developing digital library systems and technology; (6 researching browsing and search functions of the digital library; (7 exploring the model of the digital library supports e-learning. In this pilot study, we developed six Metadata standards, built 746 digital resources, constructed a digital library system and web site, and proposed the conclusions and suggestions finally.

    頁次:15-38

  9. Abstracts from the 15th International Myopia Conference

    Directory of Open Access Journals (Sweden)

    Alexandra Benavente-Perez

    2016-11-01

    against form deprivation myopia in chickens, by local signaling within the retina Ladan Ghodsi, William K. Stell O14 Contributions of ON and OFF pathways to emmetropization and form deprivation myopia in mice Machelle T. Pardue, Ranjay Chakraborty, Han na Park, Curran S. Sidhu, P. Michael Iuvone O15 Response of the human choroid to defocus Michael J Collins O16 What can RNA sequencing tell us about myopic sclera? Nethrajeith Srinvasalu, Sally A McFadden, Paul N Baird O17 Overview of dopamine, retinal function, and myopia P. Michael Iuvone O18 The eye as a "robust" optical system and myopia Pablo Artal O19 Effect of discontinuation of orthokeratology lens wear on axial elongation in children Pauline Cho, SW Cheung O20 Myopia prevention in Taiwan Pei-Chang Wu O21 Alternatives to ultraviolet light and riboflavin for in vivo crosslinking of scleral collagen Quan V. Hoang, Sally A. McFadden O22 Absence of intrinsically photosensitive retinal ganglion cells (ipRGC alters normal refractive development in mice Ranjay Chakraborty, Duk C. Lee, Erica G. Landis, Michael A. Bergen, Curran Sidhu, Samer Hattar, P. Michael Iuvone, Richard A. Stone, Machelle T. Pardue O23 Scleral micro-RNAs in myopia development and their potential as therapeutic targets Ravi Metlapally O24 Effects of the long-wavelength filtered continuous spectrum on emmetropization in juvenile guinea pigs Ruiqin Li, Qinglin Xu, Hong Zhon, Chenglin Pan, Weizhon Lan, Xiaoning Li, Ling Chen, Zhikuan Yang O25 Ocular and environmental factors associated with eye growth in childhood Scott A. Read O26 Overview- prevention and prediction of myopia and pathologic myopia Seang-Mei Saw O27 New insights into the roles of retinal dopamine in form-deprivation myopia and refractive development in C57BL/6 mice Shi-Jun Weng, Xiao-Hua Wu, Kang-Wei Qian, Yun-Yun Li, Guo-Zhong Xu, Furong Huang, Xiangtian Zhou, Jia Qu, Xiong-Li Yang, Yong-Mei Zhong O28 The effects of the adenosine antagonist, 7-methylxanthine, on refractive development in

  10. Mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after intracranial hemorrhage

    Directory of Open Access Journals (Sweden)

    Yin XP

    2015-11-01

    Full Text Available Xiao-ping Yin,1,2 Zhi-ying Chen,2 Jun Zhou,1 Dan Wu,1,3 Bing Bao2 1Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Department of Neurology, Affiliated Hospital of Jiujiang University, Jiujiang, People’s Republic of China; 3Department of Neurology, The Sixth Hospital of Wuhan, Wuhan, People’s Republic of China Background: It has been found that nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2–ARE signaling pathway plays a role in antioxidative response, anti-inflammatory response, and neuron-protection in intracerebral hemorrhage (ICH. The aim of this study is to explore mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after ICH.Methods: There were a total of 90 rats with basal ganglia hemorrhage, which were randomly divided into the following four groups: ICH (Sprague–Dawley rats with autologous femoral arterial blood injection into the basal ganglia, sulforaphane (SFN (SFN was intraperitoneally administered into rats, retinoic acid (RA (RA was intraperitoneally administered into rats, and dimethyl sulfoxide (the rats were treated with dimethyl sulfoxide. We observed the neurological score of the rats in the different groups, and collected brain tissues for immunofluorescence, Western blot, and reverse transcription polymerase chain reaction to detect expression of Nrf2, heme oxygenase (HO-1, nuclear factor-κB (NF-κB, and tumor necrosis factor-α (TNF-α.Results: The results indicated that neurological dysfunction of rats was significantly improved in the SFN group, and the expressions of Nrf2 and HO-1 in tissues surrounding the hemorrhage were increased. Also, the level of NF-κB and TNF-α were reduced compared to the ICH group. The RA group exhibited more severe neurological dysfunction and lower levels of Nrf2 and HO-1 than the SFN and ICH groups. Compared to the ICH group, the NF

  11. Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/D-α-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment

    Directory of Open Access Journals (Sweden)

    Wu H

    2016-11-01

    Full Text Available Hao Wu,1–3 Qingxiang Zhong,1,2 Rongling Zhong,4 Houcai Huang,4 Zhi Xia,4 Zhongcheng Ke,1,5 Zhenhai Zhang,1 Jie Song,1,2 Xiaobin Jia1–3 1Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 2Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Province Academy of Chinese Medicine, Nanjing, Jiangsu, 3College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 4Laboratory Animal Center, Jiangsu Province Academy of Chinese Medicine, Nanjing, Jiangsu, 5College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, People’s Republic of China Abstract: Oleanolic acid (OA is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-D-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration. The physicochemical properties of the micelles, including zeta potential, morphology, particle size, solubility, drug loading, and drug entrapment efficiency were characterized. OA release from micelles was slower than that from the free drug system. OA uptake by A549 non-small-cell lung cancer (NSCLC cells was enhanced by the micelles. A tumor model was established by injecting A549 cells into nude mice. In vivo imaging showed that OA-micelles could accumulate in the tumors of nude mice. Additionally, smaller tumor size and increased expression of pro-apoptotic proteins were observed in OA-micelle-treated mice, indicating that OA-micelles are more effective than free OA in treating cancer. In vitro experiments were performed using two NSCLC cell

  12. Soil aggregates, organic matter turnover and carbon balance in a Mediterranean eroded vineyard

    Science.gov (United States)

    Novara, Agata; Lo Papa, Giuseppe; Dazzi, Carmelo; Gristina, Luciano; Cerdà, Artemi

    2014-05-01

    dispersion, were isolated by mechanical shaking of 100 g, air-dried fine earth on a column with sieves of 250 and 63 μm using a Shaker AS 200 Sieve (RETSCH analytical, Haan, Germany) (200-mm sieves, amplitude of 2 cm, frequency of 1.6 Hz and a water flux of 2 litres minute-1). After the physical fractionation, we discriminate three main aggregate-size fractions: >250, 63-250 and Schillaci, C., Laudicina, V.A., La Mantia, T., 2013. Turnover and availability of soil organic carbon under different Mediterranean land use as estimated by 13C natural abundance. European Journal ofSoil science, 64, 466-475. DOI: 10.1111/ejss.12038 Novara, A., Gristina, L., Saladino, S., Santoro, A., Cerda, A. 2011. Soil erosion assessment on tillage and alternative soil managements in a Sicilian vineyard. Soil & Tillage Research 117:140-147. Novara, A., La Mantia, T., Barbera V., Gristina, L. 2012. Paired-site approach for studying soil organic carbon dynamics in a Mediterranean semiarid environment. Catena, 89 (1): 1-7, doi.org/10.1016/j.catena.2011.09.008 Yan-Gui, S., Xin-Rong, L., Ying-Wu, C., Zhi-Shan, Z., and Yan, L. 2013. Carbon fixaton of cyanobacterial-algal crusts after desert fixation and its implication to soil organic matter accumulation in Desert. Land Degradation & Development, 24: 342- 349. DOI 10.1002/ldr.1131

  13. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

    Directory of Open Access Journals (Sweden)

    Li JP

    2015-02-01

    Full Text Available Jin-Ping Li,1,2 Yin-Xue Yang,3 Qi-Lun Liu,1 Zhi-Wei Zhou,2,4 Shu-Ting Pan,2,5 Zhi-Xu He,4 Xueji Zhang,6 Tianxin Yang,7 Si-Yuan Pan,8 Wei Duan,9 Shu-Ming He,10 Xiao-Wu Chen,11 Jia-Xuan Qiu,5 Shu-Feng Zhou2,41Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 4Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China; 5Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 6Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 9School of Medicine, Deakin University, Waurn Ponds, VIC, Australia; 10Department of Obstetrics and Gynecology, Xiaolan People’s Hospital affiliated to Southern Medical University, Zhongshan, Guangdong, People’s Republic of China; 11Department of General Surgery, The First People’s Hospital of Shunde affiliated to Southern Medical University, Shunde, Foshan, Guangdong, People’s Republic of China Abstract: Danusertib (Danu is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl tyrosine kinase inhibitor

  14. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells

    Directory of Open Access Journals (Sweden)

    Yuan CX

    2015-03-01

    Full Text Available Chun-Xiu Yuan,1,2 Zhi-Wei Zhou,2,3 Yin-Xue Yang,4 Zhi-Xu He,3 Xueji Zhang,5 Dong Wang,6 Tianxing Yang,7 Si-Yuan Pan,8 Xiao-Wu Chen,9 Shu-Feng Zhou2 1Department of Oncology, General Hospital, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 4Department of Colorectal Surgery, General Hospital, Ningxia Medical University, Yinchuan, 5Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, 6Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 9Department of General Surgery, The First People’s Hospital of Shunde, Southern Medical University, Shunde, People’s Republic of China Abstract: Gastric cancer is the second leading cause of cancer-related death worldwide, with a poor response to current chemotherapy. Danusertib is a pan-inhibitor of the Aurora kinases and a third-generation Bcr-Abl tyrosine kinase inhibitor with potent anticancer effects, but its antitumor effect and underlying mechanisms in the treatment of human gastric cancer are unknown. This study aimed to investigate the effects of danusertib on cell growth, apoptosis, autophagy, and epithelial to mesenchymal transition and the molecular mechanisms involved in human gastric cancer AGS and NCI-N78 cells. The results showed that danusertib had potent growth-inhibitory, apoptosis-inducing, and

  15. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237 on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway

    Directory of Open Access Journals (Sweden)

    Niu NK

    2015-03-01

    Full Text Available Ning-Kui Niu,1–3 Zi-Li Wang,1 Shu-Ting Pan,2,4 Hui-Qiang Ding,1 Giang HT Au,2 Zhi-Xu He,5 Zhi-Wei Zhou,2,5 Guozhi Xiao,6 Yin-Xue Yang,7 Xueji Zhang,8 Tianxin Yang,9 Xiao-Wu Chen,10 Jia-Xuan Qiu,4 Shu-Feng Zhou2 1Department of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin, 4Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 5Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 6Department of Biochemistry, Medical Center, Rush University, Chicago, IL, USA; 7Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, 8Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 9Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 10Department of General Surgery, The First People’s Hospital of Shunde affiliated to Southern Medical University, Foshan, Guangdong, People’s Republic of China Abstract: Osteosarcoma (OS is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237 is a selective Aurora kinase A inhibitor that displays anticancer effects on several types of cancer. However, the role of ALS in the treatment of OS remains unknown. This study aimed to investigate the effects of ALS on the cell growth, apoptosis, autophagy, and epithelial to

  16. Commentary on "Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer." Gray PJ, Paly JJ, Yeap BY, Sanda MG, Sandler HM, Michalski JM, Talcott JA, Coen JJ, Hamstra DA, Shipley WU, Hahn SM, Zietman AL, Bekelman JE, Efstathiou JA. Harvard Radiation Oncology Program, Boston, MA.: Cancer 2013;119(9):1729-35. doi: 10.1002/cncr.27956. [Epub 2013 Feb 22].

    Science.gov (United States)

    Gottschalk, Alexander

    2014-04-01

    Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam therapy (PBT). The authors reviewed patient-reported outcomes data collected prospectively using validated instruments that assessed bowel and urinary quality of life (QOL) for patients with localized prostate cancer who received 3DCRT (n = 123), IMRT (n = 153) or PBT (n = 95). Clinically meaningful differences in mean QOL scores were defined as those exceeding half the standard deviation of the baseline mean value. Changes from baseline were compared within groups at the first post-treatment follow-up (2-3 months from the start of treatment) and at 12 months and 24 months. At the first post-treatment follow-up, patients who received 3DCRT and IMRT, but not those who received PBT, reported a clinically meaningful decrement in bowel QOL. At 12 months and 24 months, all 3 cohorts reported clinically meaningful decrements in bowel QOL. Patients who received IMRT reported clinically meaningful decrements in the domains of urinary irritation/obstruction and incontinence at the first post-treatment follow-up. At 12 months, patients who received PBT, but not those who received IMRT or 3DCRT, reported a clinically meaningful decrement in the urinary irritation/obstruction domain. At 24 months, none of the 3 cohorts reported clinically meaningful changes in urinary QOL. Patients who received 3DCRT, IMRT, or PBT reported distinct patterns of treatment-related QOL. Although the timing of toxicity varied between the cohorts, patients reported similar modest QOL decrements in the bowel domain and minimal QOL decrements in the urinary domains at 24 months. Prospective randomized trials are needed to further examine these differences. © 2013 Published by Elsevier Inc.

  17. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 122; Issue 6. Synthesis and aggregation study of optically active tetra--[()-2-octanyloxy]-substituted copper and nickel phthalocyanines. Fang-Di Cong Gui Gao Jian-Xin Li Guo-Qing Huang Zhen Wei Feng-Yang Yu Xi-Guang Du Ke-Zhi Xing. Full Papers Volume ...

  18. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Astrophysics and Astronomy; Volume 37; Issue 2. Issue front cover thumbnail. Volume 37, Issue 2. June 2016. Article ID 8. Stochastic Oscillations of General Relativistic Disks Described by a Fractional Langevin Equation with Fractional Gaussian Noise · Wang Zhi-Yun Chen Pei-Jie · More Details ...

  19. The effects of three different grinding methods in DNA extraction of ...

    African Journals Online (AJOL)

    uwerhiavwe

    2013-04-17

    Apr 17, 2013 ... The effects of three different grinding methods in DNA extraction of cowpea .... 100 mg of the leaf tissues were weighed in an electronic balance. CTAB method .... The primers were synthesized by Life Technologies (AB & Invitrogen). .... This work was supported by 'Shuang-Zhi Plan' of Sichuan. Agricultural ...

  20. Download this PDF file

    African Journals Online (AJOL)

    cadewumi

    1,3, Wen-Chi Chen*4. 1Department of Urology, Chang Bing Show Chwan Memorial Hospital, 2Department of Life ..... with WLS was first recorded in the book written by Ken-Tang Wang entitled “Zheng Zhi Zhun Sheng” (standards of patterns and treatment) during the Ming Dynasty (late sixteenth century). Since that time, the ...

  1. Building for the Future: China’s Progress in Space Technology During the Tenth 5-Year Plan and the U.S. Response

    Science.gov (United States)

    2008-03-01

    Navigation System,” Science and Global Security, December 2004, pp. 219-250. 68. Kang Guohua, Liu Jianye, Zhu Yanhua, and Xiong Zhi, “GPS/SST/SINS zuhe...73. Xie Tao, “‘Shen liu’ shenkong fangda ‘hangtian jingji ’” (“‘Shenzhou’ VI Amplifies the ‘Space Economy’”), Zhongguo Hangtian (Aerospace China

  2. Relationships among Constitution, Stress, and Discomfort in the First Trimester

    Directory of Open Access Journals (Sweden)

    Hsiao-Ling Wang

    2012-01-01

    trimester of pregnancy. We adopted a descriptive and correlational research design and collected data from 261 pregnant women during their first trimester in southern Taiwan using structured questionnaires. Results showed that (1 stress was significantly and positively correlated with Yang-Xu, Yin-Xu, and Tan-Shi-Yu-Zhi constitutions, respectively; (2 Yin-Xu and Tan-Shi-Yu-Zhi constitutions had significant correlations with all symptoms of discomfort, while Yang-Xu had significant correlations with all symptoms of discomfort except for “running nose”; (3 Tan-Shi-Yu-Zhi constitution and stress were two indicators for “fatigue”; Tan-Shi-Yu-Zhi was the indicator for “nausea”; Yang-Xu and Yin-Xu were indicators for “frequent urination.” Our findings also indicate that stress level affects constitutional changes and that stress and constitutional change affect the incidence of discomfort. This research can help healthcare professionals observe these discomforts and provide individualized care for pregnant women, to nurture pregnant women into neutral-type constitution, minimize their levels of discomfort, and promote the health of the fetus and the mother.

  3. Upregulation of miR-222 in both Helicobacter pylori-infected and ...

    Indian Academy of Sciences (India)

    MINA NOORMOHAMMAD

    of this study was to analyse the expression level of miR-222 in gastric cancer tissues, evaluating the relationship between. miR-222 ... using RT-qPCR and compared with 88 healthy samples. ... observed in some diseases; for instance, hepatocellular carci- noma .... cellular matrix proteins in stomach cells (Chun-Zhi et al.

  4. Fulltext PDF

    Indian Academy of Sciences (India)

    YIMING LU1,3, PING HE2,∗, SHU-HUA MA3, GUO-ZHI LI4 and. SALEH MOBAYBEN1. 1Laboratory of Train Network, Department of Train Control Tech., Research Center of Product. & Tech., CRRC TANGSHAN CO., LTD, No. 3, Changqian Rd, Fengrun DIST, Tangshan,. Hebei, 063035, People's Republic of China. 2School ...

  5. African Journal of Biotechnology - Vol 5, No 11 (2006)

    African Journals Online (AJOL)

    Seperation, identification and analysis of pigment (melanin) production in Streptomyces · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. SG Dastager, WJ Li, A Dayanand, S-K Tang, X-P Tian, X-Y Zhi, L-H Xu, C-L Jiang ...

  6. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Xing Hui Zhang1 Fu Long Zhang1 Zhi Yuan Geng2. College of Chemical Engineering, Gansu Lianhe University, Lanzhou 730010, P.R. China; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P.R. China ...

  7. Photodetachment cross-section of in a three-dimensional cubical ...

    Indian Academy of Sciences (India)

    DE-HUA WANG

    2017-10-19

    Oct 19, 2017 ... DE-HUA WANG. ∗. , PANG-ZHI .... on the surfaces along x, y, z directions, respectively. Then the ..... [20] Y Han, L F Wang, S Y Ran and G C Yang, Physica B. 405, 3082 ... [36] D H Wang, Y J Yu and S L Lin, Chin. Opt. Lett.

  8. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Journal of Astrophysics and Astronomy. JOAA-D-15-00122. Power spectrum density of stochastic oscillating accretion disk. G. B. Long, J. W. Ou and Y. G. Zheng. JOAA-D-15-00124. Stochastic oscillations of general relativistic disks described by a fractional Langevin equation with fractional Gaussian noise. Wang Zhi-Yun ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Co-expression of the C-terminal domain of Yersinia enterocolitica invasin enhances the efficacy of classical swine-fever-vectored vaccine based on human adenovirus · Helin Li Pengbo Ning Zhi Lin Wulong Liang Kai Kang Lei He Yanming Zhang · More Details Abstract Fulltext PDF. The use of adenovirus vector-based ...

  10. Connections between the Radio, Optical and Soft X-ray Luminosities ...

    Indian Academy of Sciences (India)

    for Flat-Spectrum Radio Quasars. Zhi-Fu Chen1, Cai-Juan Pan1,∗, You-Bing Li2 & Yu-Tao Zhou3. 1Department of Physics and Telecommunication Engineering of Baise University,. Baise 533000, China. 2Guangzhou City Construction College, Guangdong 510925, China. 3Center for Astrophysics, Guangzhou University, ...

  11. Li et al., Afr J Tradit Complement Altern Med. (2013) 10(5):375-379 ...

    African Journals Online (AJOL)

    cadewumi

    -gang, Zhao Jin-ning, Wang Zhi, Li Jin. (2004). Effects of Total Flavone from Drynaria Fortunei on Bone. Density and IL-6, IL-4 and TNFα Levels in Ovariectomized Rats. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 01:.

  12. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  13. Formation Energies of Native Point Defects in Strained-Layer Superlattices (Postprint)

    Science.gov (United States)

    2017-06-05

    potential; bulk materials; total energy calculations; entropy; strained- layer superlattice (SLS) 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...AFRL-RX-WP-JA-2017-0217 FORMATION ENERGIES OF NATIVE POINT DEFECTS IN STRAINED- LAYER SUPERLATTICES (POSTPRINT) Zhi-Gang Yu...2016 Interim 11 September 2013 – 5 November 2016 4. TITLE AND SUBTITLE FORMATION ENERGIES OF NATIVE POINT DEFECTS IN STRAINED- LAYER SUPERLATTICES

  14. Molecular characters and expression analysis of a new isoform of ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-10-20

    Oct 20, 2008 ... isoform of the myocyte enhancer factor 2 gene from the silkworm, Bombyx mori. Qing-zhi Ling1, 2, ... BMEF2B mRNA content in the brain was measured using the combined method of quantitative RT-PCR and Southern ... specific cofactors to control gene expression in pheno- typically different muscles.

  15. Jiang et al., Afr J Tradit Complement Altern Med. (2015) 12(S):45-51 ...

    African Journals Online (AJOL)

    Background: To explore the effects of Zhi-Bai-Di-Huang-Wan (ZBDHW), a classic formula of Chinese medicinal herbs in relieving menopausal symptoms in British and Chinese women. Methods and Materials: Between May 2011 and May 2013, 224 Chinese and British women were divided into a ZBDHW group with 115.

  16. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Schinzel–Giedion syndrome: a novel case, review and revised diagnostic criteria · WEI-LIANG LIU ZHI-XU HE FANG LI RONG AI HONG-WEI MA · More Details Abstract Fulltext PDF. Schinzel–Giedion syndrome (SGS) is a rare autosomal dominant inheritance disorder. Heterozygous de novo mutations in the SETBP1 gene ...

  17. Co-expression of the C-terminal domain of Yersinia enterocolitica ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 1. Co-expression of the C-terminal domain of Yersinia enterocolitica invasin enhances the efficacy of classical swine-fever-vectored vaccine based on human adenovirus. Helin Li Pengbo Ning Zhi Lin Wulong Liang Kai Kang Lei He Yanming Zhang. Articles Volume ...

  18. People’s Republic of China Scientific Abstracts No. 178

    Science.gov (United States)

    1977-10-27

    of hepatic colls were observed by eleotron microscopy after carbon tetrachloride intoxication in mice . The hepatic cellular injuries were protected...administration in [continuation of SHENG-WU HUA-HSUEH YU SHENG-WU WU-LI-HSUEH-PAO Vol 8, No A, Dec 76 pp 333-340] mice . It is transformed from lipid...preparations for monopolizing the technique by capi- talist and revisionist countries. In a socialist country, the author claims, the purpose of developing

  19. Effects of three warm-up regimens of equal distance on VO2 kinetics during supramaximal exercise in Thoroughbred horses.

    Science.gov (United States)

    Mukai, K; Hiraga, A; Takahashi, T; Ohmura, H; Jones, J H

    2010-11-01

    Several studies have indicated that even low-intensity warm-up increases O(2) transport kinetics and that high-intensity warm-up may not be needed in horses. However, conventional warm-up exercise for Thoroughbred races is more intense than those utilised in previous studies of equine warm-up responses. To test the hypothesis that warm-up exercise at different intensities alters the kinetics and total contribution of aerobic power to total metabolic power in subsequent supramaximal (sprint) exercise in Thoroughbred horses. Nine well-trained Thoroughbreds ran until fatigue at 115% of maximal oxygen consumption (VO2max) 10 min after warming-up under each of 3 protocols of equal running distance: 400 s at 30% VO2max (LoWU), 200 s at 60% VO2max (MoWU) and 120 s at 100% VO2max (HiWU). Variables measured during exercise were rates of O(2) and CO(2) consumption/production (VO2,VO2), respiratory exchange ratio (RER), heart rate, blood lactate concentration and accumulation rate and blood gas variables. VO2 was significantly higher in HiWU than in LoWU at the onset of the sprint exercise and HR was significantly higher in HiWU than in LoWU throughout the sprint. Accumulation of blood lactate, RER, P(a)CO(2) and PvCO2 in the first 60 s were significantly lower in HiWU than in LoWU and MoWU. There were no significant differences in stroke volume, run time or arterial-mixed venous O(2) concentration. These results suggest HiWU accelerates kinetics and reduces reliance on net anaerobic power compared with LoWU at the onset of the subsequent sprint. © 2010 EVJ Ltd.

  20. The prevalence of lacunar infarct decreases with aging in the elderly: a case-controlled analysis

    Directory of Open Access Journals (Sweden)

    Cai Z

    2016-05-01

    Full Text Available Zhiyou Cai,1 Wenbo He,1 Chuan-yong Peng,2 Jin Zhou,2 Qi-lan Xu,2 Zong-shan Wu2 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, 2The Examination Center of Magnetic Resonance Imaging, the Lu’an Affiliated Hospital of Anhui Medical University, Lu’an People’s Hospital, Lu’an, Anhui Province, People’s Republic of China Background and purpose: Lacunar infarct (LI is well known as a heterogeneous primary disorder of cerebral small vessel. Compelling results have demonstrated that age is a risk factor to the prevalence of LI. However, the relationship between age and the prevalence of LI remains obscure. It is essential to note the relationship between age and the prevalence of LI through more clinical data. Methods: A total of 3,500 patients were included in the case-controlled study. All data were collected from the Examination Center of Magnetic Resonance Imaging, Lu’an People’s Hospital from January 2014 to December 2015. A primary discharge diagnosis of LI was done, and all subjects were evaluated as retrospective data. The relationship between the risk factors and the prevalence of diabetes and the relationship between age and the prevalence of diabetes was analyzed. A chi-square test was used to analyze the associations between different variables. A one-way analysis of variance was used to test the equality of three or more means at one time by using variances. Statistical significance was defined as a P-value of <0.05. Results: The one-way analysis of variance demonstrated that the prevalence of LI increased with age before 60 years and decreased with age after 69 years. The same results were found in both the male and the female subjects. These results showed that the age-related risk factors (hypertension, diabetes, cerebral infarct, cardiovascular diseases, smoking, and drinking have no relationship with the prevalence of LI on the basis of age. There is

  1. Aitken extrapolation and epsilon algorithm for an accelerated solution of weakly singular nonlinear Volterra integral equations

    International Nuclear Information System (INIS)

    Mesgarani, H; Parmour, P; Aghazadeh, N

    2010-01-01

    In this paper, we apply Aitken extrapolation and epsilon algorithm as acceleration technique for the solution of a weakly singular nonlinear Volterra integral equation of the second kind. In this paper, based on Tao and Yong (2006 J. Math. Anal. Appl. 324 225-37.) the integral equation is solved by Navot's quadrature formula. Also, Tao and Yong (2006) for the first time applied Richardson extrapolation to accelerating convergence for the weakly singular nonlinear Volterra integral equations of the second kind. To our knowledge, this paper may be the first attempt to apply Aitken extrapolation and epsilon algorithm for the weakly singular nonlinear Volterra integral equations of the second kind.

  2. Advanced Materials and Processing 2010

    Science.gov (United States)

    Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

    2011-06-01

    Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

  3. PREFACE: Ultrathin layers of graphene, h-BN and other honeycomb structures Ultrathin layers of graphene, h-BN and other honeycomb structures

    Science.gov (United States)

    Geber, Thomas; Oshima, Chuhei

    2012-08-01

    nanometer scale. This special section contains interesting papers on graphene, h-BN and related 'honeycomb' compounds on solid surfaces, which are currently in development. Interfacial interaction strongly modifies the electronic and atomic structures of these overlayer systems and substrate surfaces. In addition, one can recognize a variety of growth phenomena by changing the surface and growth conditions, which are promising as regards fabricating those noble nanosystems. We have great pleasure in acknowledging the enthusiastic response and participation of our invited authors and their diligent preparation of the manuscripts. Ultrathin layers of graphene, h-BN and other honeycomb structures contents Ultrathin layers of graphene, h-BN and other honeycomb structuresThomas Geber and Chuhei Oshima Templating of arrays of Ru nanoclusters by monolayer graphene/Ru Moirés with different periodicitiesEli Sutter, Bin Wang, Peter Albrecht, Jayeeta Lahiri, Marie-Laure Bocquet and Peter Sutter Controllable p-doping of graphene on Ir(111) by chlorination with FeCl3N A Vinogradov, K A Simonov, A V Generalov, A S Vinogradov, D V Vyalikh, C Laubschat, N Mårtensson and A B Preobrajenski Optimizing long-range order, band gap, and group velocities for graphene on close-packed metal surfacesF D Natterer, S Rusponi, M Papagno, C Carbone and H Brune Epitaxial growth of graphene on transition metal surfaces: chemical vapor deposition versus liquid phase depositionSamuel Grandthyll, Stefan Gsell, Michael Weinl, Matthias Schreck, Stefan Hüfner and Frank Müller High-yield boron nitride nanosheets from 'chemical blowing': towards practical applications in polymer compositesXuebin Wang, Amir Pakdel, Chunyi Zhi, Kentaro Watanabe, Takashi Sekiguchi, Dmitri Golberg and Yoshio Bando BCx layers with honeycomb lattices on an NbB2(0001) surfaceChuhei Oshima Epitaxial growth of boron-doped graphene by thermal decomposition of B4CWataru Norimatsu, Koichiro Hirata, Yuta Yamamoto, Shigeo Arai and Michiko

  4. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    Science.gov (United States)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    Tegel, Inga Schellenberg, Falko M Schappacher, Rainer Pöttgen, Joachim Deisenhofer, Axel Günther, Florian Schrettle, Alois Loidl and Dirk Johrendt The superconductor KxSr1-xFe2As2: normal state and superconducting properties B Lv, M Gooch, B Lorenz, F Chen, A M Guloy and C W Chu Effect of 3d transition metal doping on the superconductivity in quaternary fluoroarsenide CaFeAsF Satoru Matsuishi, Yasunori Inoue, Takatoshi Nomura, Youichi Kamihara, Masahiro Hirano and Hideo Hosono Influence of the rare-earth element on the effects of the structural and magnetic phase transitions in CeFeAsO, PrFeAsO and NdFeAsO Michael A McGuire, Raphaël P Hermann, Athena S Sefat, Brian C Sales, Rongying Jin, David Mandrus, Fernande Grandjean and Gary J Long Heat capacity measurements on FeAs-based compounds: a thermodynamic probe of electronic and magnetic states P J Baker, S R Giblin, F L Pratt, R H Liu, G Wu, X H Chen, M J Pitcher, D R Parker, S J Clarke and S J Blundell Spin fluctuations, interband coupling and unconventional pairing in iron-based superconductors Zi-Jian Yao, Jian-Xin Li and Z D Wang Superconductivity induced by Ni doping in BaFe2As2 single crystals L J Li, Y K Luo, Q B Wang, H Chen, Z Ren, Q Tao, Y K Li, X Lin, M He, Z W Zhu, G H Cao and Z A Xu Metamagnetic transition in EuFe2As2 single crystals Shuai Jiang, Yongkang Luo, Zhi Ren, Zengwei Zhu, Cao Wang, Xiangfan Xu, Qian Tao, Guanghan Cao and Zhu'an Xu Pressure dependence of the thermoelectric power of the iron-based high-Tc superconductor SmFeAsO0.85 N Kang, P Auban-Senzier, C R Pasquier, Z A Ren, J Yang, G C Che and Z X Zhao Superconductivity in some heavy rare-earth iron arsenide REFeAsO1-δ (RE = Ho, Y, Dy and Tb) compounds Jie Yang, Xiao-Li Shen, Wei Lu, Wei Yi, Zheng-Cai Li, Zhi-An Ren, Guang-Can Che, Xiao-Li Dong, Li-Ling Sun, Fang Zhou and Zhong-Xian Zhao The delicate electronic and magnetic structure of the LaFePnO system (Pn = pnicogen) S Lebègue, Z P Yin and W E Pickett

  5. Mechanisms Involved in the Removal of Heavy Metals from Stormwater via Lignocellulosic Filtration Media

    Science.gov (United States)

    2018-01-01

    This report aims to supplement our previous report (Yonge et al. 2016; WA-RD 816.3) that assessed copper and zinc adsorption to lignocellulosic filtration media using laboratory tests and field-scale column tests for urban stormwater remediation. The...

  6. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 990 ... I: Synthesis, characterization and thermal properties of a novel polyhedral cubic silsesquioxane, Abstract PDF. Enock O. Dare, Gabriel A. Olatunji, David S. .... Vol 25, No 2 (2011), Saturated properties prediction in critical region by a quartic equation of state, Abstract PDF. Yong Wang, Guo-bo Huang, ...

  7. Annotated Bibliography for Lake Erie. Volume III. Engineering,

    Science.gov (United States)

    1974-10-01

    the ecology is examined. 83. Bar- Kochba , Y. and A. J. Simon. 1971. Rainfall and floods in Northeastern Ohio. Dept. of Eng. Univ. Akron. 87 p. This...Bar- Kochba , Y. Bergs, A. Dept. of Civil Eng. 1 Yonge Street University of Akron Toronto, Ontario Akron, Ohio 44304 Canada Barnhouse Associates Bethlehem

  8. A comparative study of the effects of cone-plate and parallel-plate geometries on rheological properties under oscillatory shear flow

    CSIR Research Space (South Africa)

    Yong Song, H

    2017-11-01

    Full Text Available -1 Korea-Australia Rheology Journal A comparative study of the effects of cone-plate and parallel- plate geometries on rheological properties under oscillatory shear flow Hyeong Yong Song1, Reza Salehiyan2, Xiaolei Li1, Seung Hak Lee1 and Kyu Hyun1...

  9. Anti-hepatitis B viral activity of Phyllanthus niruri L (Phyllanthaceae ...

    African Journals Online (AJOL)

    Yong Li, Xin Li, Jia-Kun Wang, Yan Kuang and Ming-Xiu Qi*. Centers for Disease .... sarkosyl, 7 % 2-mercaptoethanol, 4 M guanidine ..... AK, Gane E, Hou JL, Jafri W, Jia J, Kim JH, Lai CL, Lee. HC, Lim SG, Liu CJ ... Shin MS, Kang EH, Lee YI.

  10. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Hai-Liang Zhu. Articles written in Journal of Chemical Sciences. Volume 121 Issue 4 July 2009 pp 463-470. Synthesis, antimicrobial activity of lamotrigine and its ammonium derivatives · Yong Qian Peng-Cheng Lv Lei Shi Rui-Qin Fang Zhong-Cheng Song Hai-Liang Zhu.

  11. Research Article Special Issue

    African Journals Online (AJOL)

    2017-08-08

    Aug 8, 2017 ... power levels compared to the other types of land-mobile antennas [3]. Usually .... It is because the transmission of radio waves in that path is affected by ..... [21] Yong C Y, Rahman T A, Chew K M. Wireless industry emission: ...

  12. Põhja-Korea valmistub sõjaks / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2006-01-01

    Põhja-Korea juhi Kim Yong Nami sõnul on riik nõus naasma läbirääkimistele USA-ga, kui tühistataks senised sanktsioonid Põhja-Korea vastu. ÜRO Julgeolekunõukogus alustati resolutsiooniprojekti arutamist, mis näeb ette Põhja-Koreale tuumakatsetuste eest karistusi. Lisa: Kahtlane katsetus

  13. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Identification of twelve novel polymorphic microsatellite loci in the severe weed, Stellera chamaejasme L. (Thymelaeaceae) · Yong Hong Zhang Ji Pei Yue Hang Sun · More Details Fulltext PDF. pp e27-e30. Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep · Qiuyue Liu Caixia ...

  14. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Li Ruiqin. Articles written in Sadhana. Volume 31 Issue 6 December 2006 pp 661-669. Research on conceptual design of mechatronic systems · Xu Yong Zou Huijun Li Ruiqin · More Details Abstract Fulltext PDF. Based on the fact that function-structure generating and function solving are ...

  15. FORUM ISSUES IN THE ENFORCEMENT OF REGULATORY ...

    African Journals Online (AJOL)

    in his role as father of the country. In modern times, the ... of self-regulatory organisations in most financial markets who thus far have ..... companies and their officers under the Act? There are as yet no clear an- swers to ..... 578 (High Court of Singapore) where Chief Justice Yong Pung How held that to establish a breach of ...

  16. Berlinale terad / Kadri Kõusaar

    Index Scriptorium Estoniae

    Kõusaar, Kadri

    2006-01-01

    56. Berliini festivali filme - Jasmila Zhbanici "Grbavica", Michael Winterbottomi, Mat Whitecrossi "Teekond Guantanamosse", tailase Pen-ek Ratanaruangi "Nähtamatud lained", John Hillcoati "Ettepanek" (stsenarist ja muusika autor Nick Cave), Bennett Milleri "Capote" (nimiosas P.S. Hoffman), Yang Yong-hi dokfilm "Kallis Pyongyang", Tomer Heymanni dokfilm "Pabernukud"

  17. What Is the Transformational Learning Experience of Secondary Teachers Who Have Dealt with Burnout?

    Science.gov (United States)

    Sims, Julius R., I

    2013-01-01

    Burnout is a syndrome consisting of emotional exhaustion (EE) and depersonalization (DPZ) (Yong & Yue, 2007). Teachers who fall victim to burnout are likely to be less sympathetic toward students, have a lower tolerance for classroom disruption, be less apt to prepare adequately for class, and feel less committed and dedicated to their work…

  18. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. S Ramesh. Articles written in Sadhana. Volume 35 Issue 1 February 2010 pp 87-95. Preparation and characterization of plasticized high molecular weight PVC-based polymer electrolytes · S Ramesh Geok Bee Teh Rong-Fuh Louh Yong Kong Hou Pung Yen Sin Lim Jing Yi · More Details ...

  19. Geok Bee Teh

    Indian Academy of Sciences (India)

    Geok Bee Teh. Articles written in Sadhana. Volume 35 Issue 1 February 2010 pp 87-95. Preparation and characterization of plasticized high molecular weight PVC-based polymer electrolytes · S Ramesh Geok Bee Teh Rong-Fuh Louh Yong Kong Hou Pung Yen Sin Lim Jing Yi · More Details Abstract Fulltext PDF.

  20. Linkage disequilibrium and association mapping of drought ...

    African Journals Online (AJOL)

    sunny t

    2016-11-16

    Nov 16, 2016 ... related to drought tolerance (YongSheng et al., 2009). Among the variety of ... (Li et al., 2013), yield (LiFang et al., 2010) and fibre traits. (Islam et al., 2014). ..... such molecular markers as SSRs (Bertini et al., 2006;. Zhang et al.

  1. Methanotrophic abundance and community fingerprint in pine and ...

    African Journals Online (AJOL)

    Zheng Y

    2012-07-10

    Jul 10, 2012 ... in pine and tea plantation soils as revealed by molecular methods. Yong Zheng. 1 .... Soil pH was determined with a soil to water ratio of 2:5 (W/V). Soil organic matter (OM) ..... Stable isotope probing analysis of the diversity ...

  2. Reference: 759 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 759 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18434608i Guan Yue-Feng...s. 2 852-63 18434608 2008 Jun Plant physiology Gao Ju-Fang|Guan Yue-Feng|Huang Xue-Yong|Yang Zhong-Nan|Zhang Hong-Xia|Zhu Jun

  3. From the role of context to the measurement problem: The Dutch connection pays tribute to Guy Van Orden

    NARCIS (Netherlands)

    Bosman, A.M.T.; Cox, R.F.A.; Hasselman, F.W.; Wijnants, M.L.

    2013-01-01

    The call for a daisy chain of replications by Daniel Kahneman (as cited in Yong, 2012) to combat the recent credibility problems of psychological science touches upon the issue that Guy dealt with ever since he started his academic career and that we acknowledge as one of his major contributions.

  4. From the role of context to the measurement problem : The Dutch connection pays tribute to Guy Van Orden

    NARCIS (Netherlands)

    Bosman, Anna M. T.; Cox, Ralf C. A.; Hasselman, Fred; Wijnants, Maarten L.

    2013-01-01

    The call for a daisy chain of replications by Daniel Kahneman (as cited in Yong, 2012) to combat the recent credibility problems of psychological science touches upon the issue that Guy dealt with ever since he started his academic career and that we acknowledge as one of his major contributions.

  5. Is "Yin-Yang Balancing" Superior to Ambidexterity as an Approach to Paradox Management?

    DEFF Research Database (Denmark)

    Li, Xin

    2018-01-01

    ) of the Confucian principle of Zhong-Yong that is largely compatible with Aristotle’s doctrine of the mean. Second, at the practical level, his BYin-Yang balancing^ solution, while being different from the structural ambidexterity approach, is compatible with the contextual ambidexterity approach. These first two...

  6. SYNTHESIS, PHYSICO-CHEMICAL AND ANTIMICROBIAL ...

    African Journals Online (AJOL)

    userpc

    -125. Byeong G. Chae D., Hae N., Hyung K. C. and. Yong K. C. (1996); Synthesis and characterization of schiff base derived 2- hydroxy napthaldehyde and aliphatic diammines. Bulletin Korean Chemical. Society 17(8): 687-693. Hassan S. W. ...

  7. Evaluation of watermelon varieties for tolerance to powdery mildew and Phytophthora fruit rot, 2014

    Science.gov (United States)

    This experiment was conducted at the U.S. Vegetable Laboratory farm in Charleston, SC. The soil was Yonges loamy fine sand. This study was undertaken to determine the performance of seeded and seedless commercial watermelon varieties for tolerance to powdery mildew (PM) and Phytophthora fruit rot as...

  8. Author Details

    African Journals Online (AJOL)

    Huang, Yong. Vol 13, No 6 (2016) - Articles Imaging of brain function based on the analysis of functional connectivity - imaging analysis of brain function by fMRI after acupuncture at LR3 in healthy individuals. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for ...

  9. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Physics: WHEPP-XI working group report. Amol Dighe Anjan Giri Rupak Dutta Naveen Gaur Tim Gershon Diptimoy Ghosh Xiao-Gang He George W-S Hou Yong-Yeon Keum Bhavik Kodrani Namit Mahajan Joaquim Matias Barilang Mawlong Basudha Misra Rukmani Mohanta Gagan Mohanty Sudhir Vempati. Volume 76 ...

  10. Reference: 163 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 163 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15660207i Kanter Ulr...saccharides. 2 243-54 15660207 2005 May Planta Guerineau Fran巽ois|Kanter Ulrike|Li Yong|Pauly Markus|Tenhaken Raimund|Usadel Bj旦rn

  11. An Approach toward an Asia-Pacific Strategy 2012 to 2020

    Science.gov (United States)

    2014-06-01

    the Philippines, causing a significant loss to the Filipino farming industry.49 Even though no shots were fired, at the height of the conflict, the...Kim Yong-sam and Mun Il-bong, were executed in 2010; it appears that both were used as scape- goats for failed economic and security policies. In 2011

  12. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Jianchang Du1 Xingna Wang1 2 Mingsheng Zhang1 Dacheng Tian1 Yong-Hua Yang1. State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China; Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia ...

  13. The evolutionary strata of DARPP-32 tail implicates hierarchical ...

    Indian Academy of Sciences (India)

    The evolutionary strata of DARPP-32 tail implicates hierarchical functional expansion in higher vertebrates. CHOONG YONG UNG and TEOW CHONG TEOH. Supplementary data 1. Protein sequences of PPP1R1 family from 39 vertebrate species in FASTA format. Supplementary data 2. Multiple sequence alignment results ...

  14. Proton-proton elastic scattering at ultrahigh energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem (University of the Punjab, Lahore (Pakistan). Dept. of Physics)

    1981-05-30

    The authors use a geometrical model of high-energy pp elastic scattering as proposed by Chou and Yong to analyse experimental data available at present and consider the predictions of the dipole pomeron model for pp elastic scattering at ultrahigh energies. Theoretical results for differential cross sections are compared with experimental data.

  15. Yunnan Smelting Group Examines an Aluminum Project for Possible Investment

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Tian Yong,General Manager of Yunnan Smelt- ing Group,has gone to Zha gai NuoEr in Heilongjiang Province with a study group to conduct a full careful examination on the feasi- bility of the investment in the aluminum pro- ject.Yunnan Smelting Group is a large-scale

  16. African Journal of Traditional, Complementary and Alternative ...

    African Journals Online (AJOL)

    Diuretic and anti-diuretic bioactivity differences of the seed and shell extracts of Alpinia oxyphylla fruit · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Yong-hui Li, Yin-feng Tan, Na Wei, Jun-qing Zhang, 25-32 ...

  17. JIU-REN YIN

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. JIU-REN YIN. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1255-1261. Molecular dynamics study on the relaxation properties of bilayered graphene with defects · WEI ZHANG JIU-REN YIN PING ZHANG YAN-HUAI DING YONG J IANG.

  18. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    S Ramesh1 Geok Bee Teh1 Rong-Fuh Louh2 Yong Kong Hou1 Pung Yen Sin1 Lim Jing Yi1. Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Setapak, 53300 Kuala Lumpur, Malaysia; Department of Materials Science and Engineering, Feng Chia University, 100, Wenhwa Road, Seatwen, Taichung, ...

  19. Growth characteristics and productivity of cold-tolerant “Kowinearly ...

    African Journals Online (AJOL)

    Growth characteristics and productivity of cold-tolerant “Kowinearly” Italian ryegrass in the northern part of South Korea. Gi Jun Choi, Hee Chung Ji, Ki-Yong Kim, Hyung Soo Park, Sung Seo, Ki-Won Lee, Sang-Hoon Lee ...

  20. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  1. Infinite dimensional differential games with hybrid controls

    Indian Academy of Sciences (India)

    The study of differential games with Elliott–Kalton strategies in the viscosity solution ... studied by Yong [6, 7]. ... Section 3 is devoted to the proof of the main uniqueness result for SQVI and the existence ...... Moreover, we have given explicit formulation of dynamic programming ... Financial support from NBHM is gratefully.

  2. Costing Household Surveys for Monitoring Progress Toward Ending Extreme Poverty and Boosting Shared Prosperity

    OpenAIRE

    Kilic, Talip; Serajuddin, Umar; Uematsu, Hiroki; Yoshida, Nobuo

    2017-01-01

    On October 15, 2015, World Bank Group President Jim Yong Kim announced the World Bank Group’s commitment to support the 78 poorest countries to implement a multi-topic household survey every three years between 2016 and 2030, for monitoring progress toward ending extreme poverty and boosting shared prosperity. This paper estimates the resource requirements to achieve the objectives of impl...

  3. Developing rearing methods for Tetrastichus planipennisi (Hymenoptera: Eulophidae), a larval endoparasitoid of the emerald ash borer (Coleoptera: Buprestidae)

    Science.gov (United States)

    Jian J. Duan; Mike Ulyshen; Leah Bauer; Ivich. Fraser

    2011-01-01

    Tetrastichus planipennisi Yong, a gregarious koinobiont endoparasitoid, is one of three hymenopteran parasitoids being released in the U.S. for biological control of the emerald ash borer (Agrilus planipennis Fairmair, EAB), an invasive beetle from Asia causing mortality of the ash trees (Fraxinus spp.) in North...

  4. Studies on middle silkgland proteins of cocoon colour sex-limited ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 29; Issue 1. Studies on middle silkgland proteins of cocoon colour sex-limited silkworm (Bombyx mori L.) using two-dimensional polyacrylamide gel electrophoresis. Yuan-Xiang Jin Yu-Yin Chen Meng-Kui Xu Yong-Huang Jiang. Articles Volume 29 Issue 1 March 2004 pp 45- ...

  5. Evaluation of fungicide rotations for management of Phytophthora fruit rot of watermelon, 2015

    Science.gov (United States)

    The experiment was conducted at the U.S. Vegetable Laboratory farm in Charleston, SC. The soil was Yonges loamy fine sand. For the past 6 years, the field has been infested with Phytophthora capsici. The experimental design was a randomized complete block with four replications. Five-week-old seedli...

  6. High frequency plant regeneration from mature seed- derived callus ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-15

    Dec 15, 2009 ... Ki-Won Lee, Gi Jun Choi, Ki-Yong Kim, Hee Chung Ji, Hyung Soo Park, Sei Hyung Yoon and ... Gramineae family plants (Ha et al., 2001; Dong and Qu, ..... Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, ...

  7. Chapter 7: Migration and winter ecology

    Science.gov (United States)

    Deborah M. Finch; Jeffrey F. Kelly; Jean-Luc E. Cartron

    2000-01-01

    The willow flycatcher (Empidonax traillii) is a Neotropical migrant that breeds in North America, but winters in Central and northern South America. Little specific information is known about migration and wintering ecology of the southwestern willow flycatcher (E. t. extimus) (Yong and Finch 1997). Our report applies principally...

  8. Neural Resilience to Traumatic Brain Injury: Identification of Bioactive Metabolites of Docosahexaenoic Acids Involved in Neuroprotection and Recovery

    Science.gov (United States)

    2015-05-01

    Involved in Neuroprotection and Recovery PRINCIPAL INVESTIGATOR: Hee-Yong Kim CONTRACTING ORGANIZATION: Henry M. Jackson Foundation for the...O’Dell DM, Lyeth BG, Jenkins LW (1994) The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury

  9. Genetic dissection of seed vigour traits in maize (Zea mays L.) under ...

    Indian Academy of Sciences (India)

    subjected to cold stress and frequently exhibit poor early- season vigour that ... Yong Shi, Guohui Li and Zhiqiang Tian contributed equally to this work. Yu82 × Shen137 is .... Other vigour-related traits within the three parental lines exhibited no ...

  10. Biological and Clinical Characterization of Novel lncRNAs Associated with Metastatic Prostate Cancer

    Science.gov (United States)

    2014-10-01

    Matthew K. Iyer, Yang Shi, Xia Jiang, June Escara-Wilke, Rachell Brendenis, Dmitry Borkin, Anastasia K. Yocum, Dattatreya Mellacheruvu, Yuanyuan... Anastasia Yocum, Anton Poliakov, Vishal Kothari, Xiaojun Jing, Harika Gundlapalli, Xuhong Cao, Xiaoju Wang, Rohit Malik, PhD...Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry

  11. "Tallinna moodul" pakub linnale ühtset vormi / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2004-01-01

    Rahvusvahelise ideekonkursi võitis "Fold", autorid Clayton Welham ja Martin Yong Londonist. II koht tööle "Drunken Style", autorid Samson Adjei, Harry Dobbs Ja Greg Epps Londonist. III koht itaalia disaineritele, ergutuspreemiad Argentiinasse ja New Yorki. Kommenteerinud linnadisainer Aavo Ermel

  12. Multi-Mode Analysis of Dual Ridged Waveguide Systems for Material Characterization

    Science.gov (United States)

    2015-09-17

    analysis”. Instrumenta- tion and Measurement, IEEE Transactions on, 44(1):19–27, 1995. [26] Maode, Niu, Su Yong, Yan Jinkui, Fu Chenpeng, and Xu Deming ...waveguide method”. Instrumentation and Measurement, IEEE Transactions on, 46(2):519–522, 1997. [35] Wang, Shoujun, Maode Niu, and Deming Xu. “A frequency

  13. Committees

    Science.gov (United States)

    2012-11-01

    Quebec IREQ, Varennes Canada Etienne PARKINSON Andritz Hydro Ltd. Switzerland B V S S S PRASAD Indian Institute of Technology Madras India Stefan RIEDELBAUCH Stuttgart University Germany Michel SABOURIN Alstom Hydro Canada Inc Canada Bruno SCHIAVELLO Flowserve Corporation USA Katsumasa SHIMMEI Hitachi Ltd Japan Christoph SINGRTüN VDMA Germany Ale? SKOTAK CKD Blansko Engineering, a s Czech Republic Toshiaki SUZUKI Toshiba Corporation Japan Andy C C TAN Queensland University of Technology Australia Geraldo TIAGO FILHO Universidade Federal de Itajuba Brazi Thi C VU Andritz Hydro Ltd Canada Satoshi WATANABE Kyushu University Japan S H WINOTO National University of Singapore Singapore Woo-Seong WOO STX Institute of Technology Korea International Technical Committee François AVELLAN (principal) EPFL-LMH Switzerland Xingqi LUO (principal) Xi'an University of Technology China Martin BÖHLE Kaiserslautern University Germany Gerard BOIS ENSAM France Young-Seok CHOI KITECH Korea Luca d'AGOSTINO University of Pisa Italy Eduard EGUSQUIZA Polytechnical University Catalonia Spain Arpad FAY University of Miskolcz Hungary Richard FISHER Voith Hydro Inc USA Regiane FORTES-PATELLA Institute Polytechnique de Grenoble France Aleksandar GAJIC University of Belgrade Serbia José GONZÁLEZ Universidad de Oviedo Spain François GUIBAULT Ecole Polytechnique de Montreal Canada Toshiaki IKOHAGI Tohoku University Japan Chisachi KATO University of Tokyo Japan Kwang-Yong KIM Inha University Korea Youn-Jea KIM Sungkyunkwan University Korea Smaine KOUIDRI Université Pierre et Marie Curie (Paris 6) France Shengcai LI Warwick University UK Adrian LUNGU Dunarea de Jos University of Galati Romania Torbjøm K NIELSEN NTNU Norway Michihiro NISHI Tsinghua University China Peter PELZ Darmstadt University Germany Frantisek POCHYLY Brno University Czech Republic Albert RUPRECHT University of Stuttgart Germany Rudolf SCHILLING Technische University München Germany Wei SHYY HKUST Hong Kong,China Romeo SUSAN

  14. Zhu Qing Wang

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Zhu Qing Wang. Articles written in Journal of Chemical Sciences. Volume 121 Issue 4 July 2009 pp 543-548. Highly sensitive optical chemosensor for the detection of Cu using a rhodamine B spirolatam · Gen Hua Wu Dong Xiang Wang Da Yu Wu Yuan Gao Zhu Qing Wang.

  15. Biisofraxidin on Apoptosis of Human Gastric Cancer BGC-823 Cells

    African Journals Online (AJOL)

    Wu et al. Trop J Pharm Res, October 2015; 14(10): 1803. Tropical Journal of Pharmaceutical Research ... Jian-Tao Wu1,2*, She-Min Lv1, Chun-Hui Lu1, Jun Gong1 and Jian-Bo An3 ..... Zhu AK, Zhou H, Xia JZ, Jin HC, Wang K, Yan J, Zuo JB,.

  16. Developing institutional collaboration between Wageningen university and the Chinese academy of agricultural sciences

    NARCIS (Netherlands)

    Bonnema, A.B.; Lin, Z.; Qu, L.; Jacobsen, E.

    2006-01-01

    Scientific co-operation between the Chinese Academy of Agricultural Sciences (CAAS) and Wageningen University (WU) has been underway since 1990, especially in the field of plant sciences. In 2001, CAAS and WU initiated a formal joint PhD training programme to further structure their co-operation.

  17. African Journal of Biotechnology - Vol 9, No 15 (2010)

    African Journals Online (AJOL)

    cDNA, genomic sequence cloning and overexpression of ribosomal protein S16 gene (RPS16) from the Giant Panda · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. W Hou, Y Hou, Y Hao, T Zhang, Z Peng, Y Wu, G Wu, 2185-2191 ...

  18. Synthesis of agarose–metal/semiconductor nanoparticles having ...

    Indian Academy of Sciences (India)

    Wintec

    Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur PO, Bangalore 560 064 b. Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific ..... Li P, Li J, Wu C, Wu Q and Li J 2005 Nanotechno- logy. 16 1912. 18. Gadi B and Jeffrey G 2005 Curr. Med. Chem. 12 2163. 19. Gadi B and ...

  19. ACUTE EFFECTS OF STATIC STRETCHING, DYNAMIC EXERCISES, AND HIGH VOLUME UPPER EXTREMITY PLYOMETRIC ACTIVITY ON TENNIS SERVE PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Ertugrul Gelen

    2012-12-01

    Full Text Available The purpose of this study was to compare the acute effects of static stretching; dynamic exercises and high volume upper extremity plyometric activity on tennis serve performance. Twenty-six elite young tennis players (15.1 ± 4.2 years, 167.9 ± 5.8 cm and 61.6 ± 8.1 kg performed 4 different warm-up (WU routines in a random order on non-consecutive days. The WU methods consisted of traditional WU (jogging, rally and serve practice (TRAD; traditional WU and static stretching (TRSS; traditional WU and dynamic exercise (TRDE; and traditional WU and high volume upper extremity plyometric activity (TRPLYP. Following each WU session, subjects were tested on a tennis serve ball speed test. TRAD, TRSS, TRDE and TRPLYO were compared by repeated measurement analyses of variance and post-hoc comparisons. In this study a 1 to 3 percent increase in tennis serve ball speed was recorded in TRDE and TRPLYO when compared to TRAD (p 0.05. ICCs for ball speed showed strong reliability (0.82 to 0.93 for the ball speed measurements.The results of this study indicate that dynamic and high volume upper extremity plyometric WU activities are likely beneficial to serve speed of elite junior tennis players.

  20. Women in physics

    CERN Document Server

    Indovino, Shaina

    2013-01-01

    What does it take to be a physicist? Lise Meitner, Katharine Blodgett, Maria Goeppert-Mayer, Chien-Shiung Wu, Ursula Franklin, Argelia Velez-Rodriguez, Sau Lan Wu, Shirley Ann Jackson, Lisa Randall and opportunities for women in physics today.

  1. DMPD: Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15331118 Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. Wu...e-associated up-regulation in macrophage PGE2 synthesis. PubmedID 15331118 Title Mechanism of age-associated... up-regulation in macrophage PGE2 synthesis. Authors Wu D, Meydani SN. Publicatio

  2. Spectrum-effect relationships between high performance liquid ...

    African Journals Online (AJOL)

    promoting effect on contractility of intestinal smooth was carried out to ... addition, the equation of spectrum-effect relationships {Y = 3.818 - 1.126X1 + ..... Peng W, Liu YJ, Wu N, Sun T, He XY, Gao YX, Wu CJ. ... Zheng QF, Zhao YL, Wang JB, Liu TT, Zhang B, Gong ... Zhao HY, Han X. Research thoughts and application.

  3. Download this PDF file

    African Journals Online (AJOL)

    pc

    2017-11-10

    Nov 10, 2017 ... ts of alkyl chain length on particles morphology were primarily studied ..... [3] Li Z, Yu L, Zheng L, Li N, Han S, Li G. Characterization studies on the ionic ... [4] Chiang YD, Lian HY, Leo SY, Wang SG, Yamauchi Y, Wu KC. ... [20] Yu YJ, Xing JL, Pang JL, Jiang SH, Lam KF, Yang TQ, Xue QS, Zhang K, Wu P.

  4. Fundamental Investigations into the Infrared Properties of Carbon Nanotubes

    Science.gov (United States)

    2013-01-23

    Vallejo , Rongtao Lu, Judy Wu. Development of Textured Magnesium Oxide Templates on Amorphous Polymer SurfacesUsing Ion-Beam-Assisted Deposition, Applied...Applied Physics Letters 99, 023111 (2011) 18. A. Elliot, Vallejo , R.T. Lu, and J.Z. Wu, “Development of Textured Magnesium Oxides Templates on

  5. Vegetation Impact on Soil Strength: A State of the Knowledge Review

    Science.gov (United States)

    2017-06-20

    CRREL SR-17-2 3 soil layers. However, their more thorough look at the Wu (1976) and Wal- dron (1977) root–soil model for soil cohesion indicated a...trafficability and mobility simulations (Wu 1976; Waldron 1977; Wal- dron and Dakessian 1981 as cited in Pirnazarov and Sellgren 2015). Figure 6. Maximum

  6. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Anhua Wu. Articles written in Bulletin of Materials Science. Volume 27 Issue 4 August 2004 pp 333-336 Crystal Growth. Bridgman growth and defects of Nd : Sr3Ga2Ge4O14 laser crystals · Jiaxuan Ding Anhua Wu Jiayue Xu · More Details Abstract Fulltext PDF.

  7. Structural basis for corepressor assembly by the orphan nuclear receptor TLX

    OpenAIRE

    Zhi, Xiaoyong; Zhou, X. Edward; He, Yuanzheng; Searose-Xu, Kelvin; Zhang, Chun-Li; Tsai, Chih-Cheng; Melcher, Karsten; Xu, H. Eric

    2015-01-01

    The orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions primarily as a transcription repressor through recruitment of Atrophin corepressors, which bind to TLX via a conserved peptide motif termed the Atro box. Zhi et al. report crystal structures of the human and insect TLX ligand-binding domain in complex with Atro box peptides. Mutations that weaken the TLX–Atrophin interaction compromise the repressive activity of TLX. In addition, mutations...

  8. Rein and Zheng Elected to American Academy of Microbiology | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer Earlier this year, Alan Rein, Ph.D., and Zhi-Ming (Thomas) Zheng, M.D., Ph.D., were elected to fellowship in the American Academy of Microbiology, the honorific leadership group within the American Society for Microbiology (ASM). They were among 88 microbiologists who were elected to the academy “through a highly selective, peer-review process,

  9. Computer Graphics Research Laboratory Quarterly Progress Report Number 49, July-September 1993

    Science.gov (United States)

    1993-11-22

    20 Texture Sampling and Strength Guided Motion: Jeffry S. Nimeroff 23 21 Radiosity : Min-Zhi Shao 24 22 Blended Shape Primitives: Douglas DeCarlo 25 23...placement. "* Extensions of radiosity rendering. "* A discussion of blended shape primitives and the applications in computer vision and computer...user. Radiosity : An improved version of the radiosity renderer is included. This version uses a fast over- relaxation progressive refinement algorithm

  10. USSR Report, Life Sciences, Biomedical and Behavioral Sciences, No. 38.

    Science.gov (United States)

    1983-07-22

    However, in the last few years a few of these factories have begun to have problems. After getting all sorts of good food, the chickens are begin...ning to fail and get sick. This is an extremely pressing problem today, being studied by different specialists. I think the major problem here is...34Ispol’zovaniye Proteina Kormov Zhi- votnymi" _/Utilization of Feed Protein by Animals/, Moscow, 1979, pp 123- 141. 43. Kale, K. ,_in the book

  11. BIOTECHNOLOGICAL APPLICATIONS AND POTENTIAL USES OF THE MUSHROOM TRAMESTES VERSICOLOR

    OpenAIRE

    CÓRDOBA M., Ketty A.; RÍOS H., Alicia

    2012-01-01

    The use of products obtained from fungi (particularly mushrooms) has increased lately due to their broad applicability in different scientific and industrial fields. The genus Trametes comprises a group of white rot producing ligninolytic fungi, with medicinal properties, biotechnological importance and environmental applications. One of the most potentially useful species is T. versicolor, formerly known as Coriolus versicolor or Polyporus versicolor. Also known as Yun Zhi in China, is a fun...

  12. Myometrial invasion and overall staging of endometrial carcinoma: assessment using fusion of T2-weighted magnetic resonance imaging and diffusion-weighted magnetic resonance imaging

    OpenAIRE

    Guo, Yu; Wang, Ping; Wang, Penghui; Gao, Wei; Li, Fenge; Yang, Xueling; Ni, Hongyan; Shen, Wen; Guo, Zhi

    2017-01-01

    Yu Guo,1,2 Ping Wang,2 Penghui Wang,2 Wei Gao,1 Fenge Li,3 Xueling Yang,1 Hongyan Ni,2 Wen Shen,2 Zhi Guo1 1Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, 2Department of Radiology, Tianjin First Center Hospital, The First Central Clinical College of Tianjin Medical University,...

  13. Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

    Directory of Open Access Journals (Sweden)

    Hongmei Jia

    2013-01-01

    Full Text Available This study proposed a new strategy for uncovering the active chemical constituents of a traditional Chinese medicines (TCMs formula, Chaihu-Shu-Gan-San (CSGS. Metabonomics and chemical profile were integrated in combination with the multivariate statistical analysis (MVA to discover the chemical constituents which contribute to the antidepressant effect of CSGS. Based upon the difference between CSGS and QZ (CSGS without Zhi-Qiao extracts in the chemical profiles and the regulations of metabolic disturbances induced by CUMS, synephrine, naringin, hesperidin, and neohesperidin were recognized as the active constituents of CSGS from Zhi-qiao responsible for those missing regulations of CSGS when Zhi-Qiao was subtracted from the whole formula. They participated in the regulations of the deviated metabolites 2–4, 10–14, and 22–25, involved in metabolic pathways of ketone bodies synthesis, phenylalanine, tyrosine and tryptophan biosynthesis, valine, aspartate, glutamate metabolism, and glycolysis/gluconeogenesis. Furthermore, the assay of MAO-A activity confirmed the potential antidepressant effect of naringin and its active sites on the MAO-A was inferred by molecular docking study. The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula.

  14. Precooling and Warm-Up Effects on Time Trial Cycling During Heat Stress.

    Science.gov (United States)

    Al-Horani, Ramzi A; Wingo, Jonathan E; Ng, Jason; Bishop, Phillip; Richardson, Mark

    2018-02-01

    Heat stress limits endurance exercise performance. Combining precooling and warm-up prior to endurance exercise in the heat may exploit the benefits of both strategies while avoiding the potential negative consequences of each. This study tested the hypothesis that precooling combined with warm-up improves time trial cycling performance in the heat relative to either treatment alone. Nine healthy men completed three 16.1-km time trials in 33°C after: 1) precooling (ice slurry and ice vest) alone (PREC); 2) warm-up alone (WU); or 3) PREC plus WU (COMBO). Tre was lower after PREC compared to WU throughout exercise and lower than COMBO for the first 12 km; COMBO was lower than WU for the first 4 km. Tsk during PREC was lower than COMBO and WU for the first 8 km, and lower in COMBO than WU for the first 4 km. PREC lowered pre-exercise heart rate relative to COMBO and WU (68 ± 10, 106 ± 12, 101 ± 13 bpm, respectively), but it increased similarly during exercise. Local sweat rate (SR) was lower in PREC (0.1 ± 0.1 mg · cm-2 · min-1) than COMBO (0.5 ± 0.2 mg · cm-2 · min-1) and WU (0.6 ± 0.2 mg · cm-2 · min-1) for the first 4 km. Treatments did not differentially affect performance (PREC = 31.9 ± 1.9 min, COMBO = 32.6 ± 2.7 min, WU = 33.1 ± 2.9 min). We conclude precooling alone or with warm-up mitigated thermal strain during exercise, but did not significantly improve 16.1-km cycling time trial performance.Al-horani RA, Wingo JE, Ng J, Bishop P, Richardson M. Precooling and warm-up effects on time trial cycling during heat stress. Aerosp Med Hum Perform. 2018; 89(2):87-93.

  15. People’s Republic of China Scientific Abstracts, Number 177

    Science.gov (United States)

    1977-10-06

    PAO [ARCHITECTURAL JOURNAL] No 2, June 1977 1 CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] No 4, December 1976 13 CHIH-WU TSA-CHIH [JOURNAL OF BOTANY...10424 CSO: 4009 12 ACTA BOTANICA SINICA AUTHOR: None ORG: Three-in-one Combination Experimental Group of Peking Ch’ung-wen Vegetable Station...Physiological Processes of Stored Tomatoes" SOURCE: Peking CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] in Chinese Vol 18, No 4, Dec 76 pp 278-283 TEXT OF

  16. The Role of Retinal Determination Gene Network (RDGN) in Hormone Signaling Transduction and Prostate Tumorigenesis

    Science.gov (United States)

    2013-10-01

    Wu K, Wang L, Jiao X, Ju X, Li Z, Ertel A, Addya S, McCue P, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG. Androgen therapy resistant...Li Z, Hu J, Chen K, Wu J, Pestell RG. DACH1 inhibited prostate cancer cellular proliferation and Interleukon-6 signaling. AACR 103rd Annual Meeting...March 31 – April 4, 2012, Chicago, IL.  Wang J, Cai S, Chen K, Sun Y, Li S, Pestell RG, Wu K. Regulation of AR transcriptional activity and

  17. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Mehmet Tok

    2001-08-01

    -bans arasındaki ilişkiyi araştırmak için yapılmıştır. Ölüm sonrası 48 tavşanın göz sıvısı Model 754 spektrofotomet-re ile apt dalgaboyunda (420 nm incelendi. BULGU-LAR.Tavşanlarda ölümden sonraki 0-72 saatler arasında postmortem interval (Y ile göz sıvısının absorbansı (X arasında pozitif lineer regresyon (r = 0.98327, P < 0.05 saptandı. Lineer regresyon formülü Y = 453.30 X + 0.75 olarak bulundu (Y = postmortem interval = PMI, X = göz sıvısı absorbansı. SONUÇ: Göz sıvısı absorbansı PMİ hesaplamada ilk 72 saatte referans gösterge olabilir. FARELERDE KAPALI BEYİN TRAVMASINA BAĞLI PATOLOJİK DEĞİŞİMLERİN H.E., ESTARİFİKASYON GÜMÜŞ BOYASI VE İMMÜNOHİSTOKİMYASAL BOYA İLE ÇALIŞILMASI A study on pathological changes of closed diffuse brain injury in rats with H.E., esterification-silver stain and albumin immunohistochemical stain Yu X], Xiao F, Wu JW, Wu MY. Fa Yi Xue Za Zhi 2001 May;17(2:69-73, 76 AMAÇ: Beyin hasarının hemen ardından ve 15 dakika ile 5 gün içerisinde ölen farelerde kapalı diffüz beyin hasarına bağlı patolojik değişimlerin incelenmesi. YÖNTEM: Kapalı diffüz beyin hasarını incelemek için H.E ve esterifikasyon-gümüş boyaları uygulandı. BULGULAR: Künt travmanın hemen ardından ölen farelerde beyin dokusunda, özellikle beyin sapında çok sayıda büzüşmüş nöron ( tip 1 değişim , şişmiş nöron (tip 2 değişim, ve dalga görünümlü sinir lifleri ayırt edildi.Travmayı izleyen 2-8. saatlerde beyin ödemi ve korteks ve beyaz cevherde, özellikle beyin sapında aksonal şişme belirgin şekilde gözlendi.Travmayı izleyen 8-24. saatlerde aksonal retraksiyon topları izlenmeye başlandı. Yaşam süresi uzadıkça tip 1 ve tip 2 değişim gösteren nöronların ve kont-raksiyon toplarının miktarının arttığı izlendi. 4. ve 5. günlerden sonra beyin ödeminin gerilediği, ancak retraksiyon topları ve aksonal şişliğin hala sürmekte olduğu g

  18. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Lihua Jiang1 Aiyi Zhu1 Jianse Zhang1 Changwen Wu1. National Engineering Research Center of Marine Facilities Aquaculture, College of Marine Science, Zhejiang Ocean University, Zhoushan 316022, China ...

  19. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Use of artificial neural network for spatial rainfall analysis .... GIS and SBF for estimating groundwater recharge of a mountainous basin in the Wu River ... Hydrogeological and geophysical study for deeper groundwater resource in quartzitic ...

  20. Arsenic bioleaching in medical realgar ore and arsenic- bearing ...

    African Journals Online (AJOL)

    Oxidation of these two ores by sulfuric acid was insignificant, as maximum arsenic leaching ratios ... Poor water solubility and weak gastrointestinal absorption of coarse ..... Wu XH, Sun DH, Zhuang ZX, Wang XR, Gong HF, Hong. JX, Lee FSC.

  1. Combined usage of testosterone and nandrolone may cause heart ...

    African Journals Online (AJOL)

    User

    2011-05-09

    May 9, 2011 ... blood urea nitrogen were measured with an auto-analyzer. Combined use of ... lation of protein synthesis in an anabolic manner (Wu,. 1997; Basaria et .... Ayotte C (2006). Significance Of 19-norandrosterone in athletes' urine.

  2. 76 FR 6769 - Office of Postsecondary Education, Overview Information, Undergraduate International Studies and...

    Science.gov (United States)

    2011-02-08

    ... propose the development of area or international studies programs to include language instruction in any..., Burmese, Cebuano (Visayan), Chechen, Chinese (Cantonese), Chinese (Gan), Chinese (Mandarin), Chinese (Min), Chinese (Wu), Croatian, Dari, Dinka, Georgian, Gujarati, Hausa, Hebrew (Modern), Hindi, Igbo, Indonesian...

  3. Vaimse tervise ümarlaud - ühisüritus vaimse tervise heaks / Lauraliisa Heidmets, Merike Sisask

    Index Scriptorium Estoniae

    Heidmets, Lauraliisa

    2009-01-01

    Ülevaade Eesti-Rootsi Vaimse Tervise ja Suitsidoloogia Instituudi (ERSI), sotsiaalministeeriumi ja Tervise Arengu Instituudi (TAI) korraldatud ümarlauast. Ettekannetega esinesid ka TLÜ sotsioloogia doktorandid Merike Sisask, Jing Wu, Piret Visnapuu ning prof. Airi Värnik

  4. Stochastic quantization of the Kink solution of phi4 field theory

    International Nuclear Information System (INIS)

    Kates, R.; Rosenblum, A.

    1989-01-01

    The method of Parisi-Wu Stochastic quantization in quantum field theory is compared to earlier work in classical field equations. The method is applied to solve for the propagator for Phi 4 field theory by perturbing the Kink solution

  5. Marginal scorch caused by Alternaria alternata on Purple-Caitai ...

    African Journals Online (AJOL)

    Marginal scorch caused by Alternaria alternata on Purple-Caitai (Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee) in China. Qijun Nie, Zhongjiu Jiao, Fengjuan Zhu, Zhenbiao Jiao, Xiaohui Deng, Zhengming Qiu, Jinping Wu ...

  6. African Journal of Biotechnology - Vol 11, No 70 (2012)

    African Journals Online (AJOL)

    Embryogenesis and plant regeneration from unpollinated ovaries of Amorphophallus konjac · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Lingling Zhao, Jinping Wu, Ying Diao, Zhongli Hu, 13472-13476 ...

  7. Wyrtki Jets: Role of Intraseasonal forcing

    Indian Academy of Sciences (India)

    44

    2018-04-16

    Apr 16, 2018 ... and global climate system (Vinayachandran et al., 1999; Murtugudde and .... wind forcing influence the WJs? and how does this relate to its observed ...... Lau, K., and H. Wu, 2010: Characteristics of precipitation, cloud, and la-.

  8. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2018-03-07

    Mar 7, 2018 ... Faculty of Business, Multimedia University, 75450 Melaka, Malaysia ..... call-taxi App. In 25th Australasian Conference on Information Systems, 2014, pp. .... [31] Wu M. L. SPSS statistical application practice: Questionnaire ...

  9. Transfusion reaction - hemolytic

    Science.gov (United States)

    ... Names Blood transfusion reaction Images Surface proteins causing rejection References Choate JD, Maitta RW, Tormey CA, Wu ... PA: Elsevier Saunders; 2016:chap 177. Hall JE. Blood types; transfusion; tissue and organ transplantation. In: Hall JE, ...

  10. Total phenolic, condensed tannin and antioxidant activity of four ...

    African Journals Online (AJOL)

    Administrator

    2011-09-07

    Sep 7, 2011 ... the common fruits and vegetables across the US (Wu et al., 2004). ... or pellicle were separated from the shell by cracking with a small hammer ..... shell (Carya Illinoensis), pomegranate husk (Punica granatum) and creosote ...

  11. Protective effect of rhamnopyranosyl vanilloyl isolated from ...

    African Journals Online (AJOL)

    Cai Tian Di Wang in 2013 and authenticated by. Chang-Wu Wang, a ... purchased from Abcam (Cambridge, UK) and ..... Hosaka T, Suzuki F, Kobayashi M, Seko Y, Kawamura Y, ... Han JJ, Ning N. Research progress on pharmacological.

  12. Lyme Disease Tests

    Science.gov (United States)

    ... Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 1538. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, 12th Edition: Mosby Elsevier Press, St. Louis, MO. ...

  13. Fungal Tests

    Science.gov (United States)

    ... Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 1569, 1570, 1532, 1616. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, Twelfth Edition: Mosby Elsevier Press, St. Louis, Missouri. ...

  14. Chickenpox and Shingles Tests

    Science.gov (United States)

    ... Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests , Fourth Edition: Saunders Elsevier, St. Louis, MO. Pp 1623. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology , Twelfth Edition: Mosby Elsevier Press, St. Louis, MO. ...

  15. An MOT-TDIE solver for analyzing transient fields on graphene-based devices

    KAUST Repository

    Shi, Yifei; Li, Ping; Uysal, Ismail Enes; Ulku, Huseyin Arda; Bagci, Hakan

    2016-01-01

    -RBC) and Poggio-Miller-Chang-Harrington-Wu-Tsai (TD-PMCHWT) integral equation, which are enforced on the surfaces of the graphene and dielectric substrate, respectively. The expressions of the time domain resistivity and conductivity of the graphene sheet

  16. Pop / Andri Riid

    Index Scriptorium Estoniae

    Riid, Andri, 1972-

    2008-01-01

    Heliplaatidest: Nice Try "Nice Try", Wu Tang Clan "8 Diagrams", Niki "Äike päike", Röövel Ööbik "Popsubterranea", Tijuana Mon Amour Broadcasting Inc. "Cold Jubilee (of the Snowqueen), "Holy Fuck "LP"

  17. Synthesis and characterization of electrochemically-reduced graphene

    Indian Academy of Sciences (India)

    Keywords. Graphene; electrochemical deposition; heat treatment; conductivity. 1. Introduction ... solar cells (Wu et al 2008; Sima et al 2011), molecular gas sensors ... solved in deionized (DI) water to obtain 0·01 M of electrolyte solution (Su et ...

  18. Media and Security Team

    Data.gov (United States)

    Federal Laboratory Consortium — The Media And Security Team led by Prof. Min Wu was established in Fall 2001 at University of Maryland, College Park. A number of research and education activities...

  19. Genomewide analysis of MATE-type gene family in maize reveals ...

    Indian Academy of Sciences (India)

    Huasheng Zhu and Jiandong Wu contributed equally to this work. As a group of secondary active transporters, the MATE gene family consists of multiple genes that widely exist in ..... Roots of the stress-treated plants were collected at 0,.

  20. T'ai Chi

    Science.gov (United States)

    ... are different styles of t'ai chi, including: Chen style Hao (or Wu Shi) style Hu Lei ... medical advice, diagnoses, and treatment, consult your doctor. © 1995- The Nemours Foundation. All rights reserved. Images provided ...

  1. Autism and green space_clean

    Data.gov (United States)

    U.S. Environmental Protection Agency — Autism and green space metrics in California elementary school districts. This dataset is associated with the following publication: Wu, J., and L. Jackson. Inverse...

  2. African Journal of Biotechnology - Vol 5, No 6 (2006)

    African Journals Online (AJOL)

    -related protein kinase2 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Huawen Zou, Xiuhai Zhang, JiuRan Zhao, Qing Yang, Zhongyi Wu, Fengge Wang, Conglin Huang, 490-496 ...

  3. Transient analysis of plasmonic nanostructures using an MOT-PMCHWT solver

    KAUST Repository

    Uysal, Ismail Enes; Ulku, Huseyin Arda; Bagci, Hakan

    2015-01-01

    A marching on in time (MOT) scheme for solving the Poggio-Miller-Chan-Harrington-Wu-Tsai (PMCHWT) surface integral equation on plasmonic nanostructures is described. The proposed scheme calls for temporal convolutions of the permittivity and Green

  4. Biological and technological effects of some mulberry varieties and ...

    African Journals Online (AJOL)

    egyptian hak

    synthesize different types of antioxidant compounds and activate key ... the nutrient uptake of rice plants, especially phosphorous and potassium (Wu et al ... agricultural products and cause detrimental effects to environment and human health.

  5. Electromagnetic properties of low-spin states in 102,104Pd

    International Nuclear Information System (INIS)

    Luontama, M.; Julin, R.; Kantele, J.; Passoja, A.; Trzaska, W.; Baecklin, A.; Jonsson, N.G.; Westerberg, L.

    1985-12-01

    Electromagnetic transitions from low-lying 0 + , 2 + , 4 + and 3 - states in 102 , 104 Pd have been studied with (p,2n) and (p,p) reactions and with Coulomb excitation. The E2 transition probabilities from the 0 3 + state in 102 Pd (13 W.u.) and from the 0 2 + state in 104 Pd (14 W.u.) are somewhat low for two-phonon states. Generally, the E2 transition rates are reasonably well reproduced by the IBA-2 and by the boson-expansion description. The intruding 0 2 + state (tsub(1/2) = 14.3 ns) in 102 Pd is connected to the 2 2 + and 2 3 + states via strong E2 transitions: B(E2;0 2 + →2 2 + )=96+-40 W.u.; B(E2;2 3 + →0 2 + )=17+-8 W.u

  6. Distribution of organochlorine pesticides and polychlorinated ...

    African Journals Online (AJOL)

    SARAH

    2015-04-30

    Apr 30, 2015 ... compartments of the environment (soil, water, air.) (Wu et al., 1999, Jiang ... toxicity and bioaccumulation through the food chain and their long-range ... they are used for fisheries, aquaculture, touristic and transport activities.

  7. The 71F Advantage: Applying Army Research Psychology for Health and Performance Gains

    Science.gov (United States)

    2010-08-01

    absolutely stellar editing and review assistance was provided by CTNSP Research Assistants Yong- Bee Lim, Simone Erchov, and Anna Nelson (whom we borrowed...global characteristics of personality structure: The NEO five-factor model and skimming the surface of the wetlands of personality. Psybernetika...because the IPIP–NEO includes Liberalism as one of its facets and its Imagination facet includes such items as “enjoy[s] wild flights of fan- tasy

  8. Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

    OpenAIRE

    Zulkawi N; Ng KH; Zamberi NR; Yeap SK; Satharasinghe DA; Tan SW; Ho WY; Abd Rashid NY; Md Lazim MI; Jamaluddin A; Alitheen NB; Long K

    2018-01-01

    Noraisyah Zulkawi,1 Kam Heng Ng,1 Nur Rizi Zamberi,2,3 Swee Keong Yeap,4 Dilan A Satharasinghe,5 Sheau Wei Tan,2 Wan Yong Ho,6 Nur Yuhasliza Abd Rashid,3 Mohd Izwan Md Lazim,3 Anisah Jamaluddin,3 Noorjahan Banu Alitheen,2,7 Kamariah Long3 1Technical Research – Product Development Department, Elken Global Sdn. Bhd, Kuala Lumpur, Malaysia; 2Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Malaysian Agricultural Research and Development Institute (MARDI), ...

  9. Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

    OpenAIRE

    Zulkawi,Noraisyah; Ng,Kam Heng; Zamberi,Nur Rizi; Yeap,Swee Keong; Satharasinghe,Dilan; Tan,Sheau Wei; Ho,Wan Yong; Abd Rashid,Nur Yuhasliza; Md Lazim,Mohd Izwan; Jamaluddin,Anisah; Alitheen,Noorjahan; Long,Kamariah

    2018-01-01

    Noraisyah Zulkawi,1 Kam Heng Ng,1 Nur Rizi Zamberi,2,3 Swee Keong Yeap,4 Dilan A Satharasinghe,5 Sheau Wei Tan,2 Wan Yong Ho,6 Nur Yuhasliza Abd Rashid,3 Mohd Izwan Md Lazim,3 Anisah Jamaluddin,3 Noorjahan Banu Alitheen,2,7 Kamariah Long3 1Technical Research – Product Development Department, Elken Global Sdn. Bhd, Kuala Lumpur, Malaysia; 2Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Malaysian Agricultural Research and Development Institute (MARD...

  10. The Role of SIRT1 In Breast Cancer Stem Cells

    Science.gov (United States)

    2016-09-01

    2009;9:123-8. 56. Ma W, Xiao GG, Mao J, Lu Y, Song B, Wang L, Fan S, Fan P, Hou Z, Li J, Yu X, 20 Wang B, Wang H, Wang H, Xu F, Li Y, Liu Q, Li L...Int J Biol Sci. 2010;6:599-612. 63. Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X

  11. Vanishing of Littlewood-Richardson polynomials is in P

    OpenAIRE

    Adve, Anshul; Robichaux, Colleen; Yong, Alexander

    2017-01-01

    J. DeLoera-T. McAllister and K. D. Mulmuley-H. Narayanan-M. Sohoni independently proved that determining the vanishing of Littlewood-Richardson coefficients has strongly polynomial time computational complexity. Viewing these as Schubert calculus numbers, we prove the generalization to the Littlewood-Richardson polynomials that control equivariant cohomology of Grassmannians. We construct a polytope using the edge-labeled tableau rule of H. Thomas-A. Yong. Our proof then combines a saturation...

  12. Phenotype-gene: 471 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available itivity toward in organ named guard cell under influence of abscisic acid for AT1G30270 Cheong Yong Hwa et a...eased sensitivity toward in organ named guard cell under influence of abscisic acid http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u878i AT1G30270

  13. International Conference on Organometallic Chemistry (13th) Held in Torino, Europe on 4-9 September 1988. Abstracts

    Science.gov (United States)

    1988-09-09

    190, 8057 ZUrich, Switzerland Joseph Edwin and William E.Geiger, Department of Chemistry, University of Vermont, Burlington, Vermont, 05405 Arnold L...On Synthesis Of Dialkyl d-Trimethylsilyloxyalkylphosphonates Zhao Yong-Zhen and Li Zhong- Rua Dpartment o chemistry, Hua Zhong Normal University, Wuhan...Jose Vicente. Jose-AntelC hAd. Na-Yeij~xa Qhicote. Ju~an-Francisco Gutliez-Jugo. Carmen Ramirez do Arel lano. Departamento do Oulmica InordanIca

  14. Tallinna Moodul = Tallinn Module / Siiri Vallner

    Index Scriptorium Estoniae

    Vallner, Siiri, 1972-

    2004-01-01

    Rahvusvahelisest disainivõistlusest Tallinna Moodul, mille eesmärk oli leida tänavamööbli süsteem, kus erinevad elemendid (kioskid, telefoniputkad, istepingid, bussiootepaviljonid, reklaamialused jne.) on seotud kontseptuaalselt ühtseks tervikuks. Osalejatest, võidutöödest. Preemiad: I - Clayton Welham, Martin Yong, London, II - Samson Adjei, Harry Dobbs, Greg Epps, London, III - Carmelo Baglivo, Luca Galofaro, Rooma. Eripreemiad (2)

  15. Do parents of children with attention-deficit/hyperactivity disorder (ADHD) receive adequate information about the disorder and its treatments? A qualitative investigation

    OpenAIRE

    Ahmed, Rana; Borst,Jacqueline; Wei,Yong; Aslani,Parisa

    2014-01-01

    Rana Ahmed,1 Jacqueline M Borst,2 Cheng Wei Yong,3 Parisa Aslani1 1Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia; 2Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; 3School of Pharmacy, The University of Nottingham, Nottingham, UK Background: Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent pediatric neurodevelopmental condition, commonly treated using pharmacological agents such as stimulant medicines. The use o...

  16. The quantum cosmology of Einstein-Yang-Mills theory in Eight-dimensions

    International Nuclear Information System (INIS)

    Su Bing; Li Xinzhou

    1991-01-01

    The quantum cosmology of Einstein-Yang-Mills has been studied. The Hartle-Hawking's proposal for the boundary conditions of the universe is extended to Eight-dimensional Einstein-Yong-Mills theory. A miniuperspace wave function is calculated in the classical limit corresponding to a superposition of classical solutions in which four of the dimensions remain small while the other four behave like an inflationary universe

  17. Neuro Inspired Adaptive Perception and Control for Agile Mobility of Autonomous Vehicles in Uncertain and Hostile Environments

    Science.gov (United States)

    2017-02-08

    Strategy for Ambush Avoidance, AAAI Conference on Artificial Intelligence . 28-JAN-15, Austin, TX. : , S.-Z. Yong, B. Paden, and E. Frazzoli...Object-based Bayesian Framework for Top-down Visual Attention, Twenty-Sixth AAAI Conference on Artificial Intelligence . , . : , Kyel Ok, Duy-Nguyen...Conference on Intelligent Robots and Systems. 28-SEP-15, . : , Jiaping Zhao, Christian Siagian, Laurent Itti. Fixation Bank : Learning to Reweight Fixation

  18. Simulative calculation of bromo-polystyrene mechanical properties

    CERN Document Server

    Wang Chao; Tang Yong Jian

    2002-01-01

    The non-crystal model of polystyrene and bromo-polystyrene was established with the help of simulative software in the computer. DREIDING was chosen as force field and its parameters is modified according to the published data. Based on the calculation results and other published data the mechanism properties of polystyrene and bromo-polystyrene, such as bulk module, Yong's module and Poisson's ratios, were discussed

  19. Targeting Epigenetic Mechanisms in Pain due to Trauma and Traumatic Brain Injury(TBI)

    Science.gov (United States)

    2016-10-01

    after incision and TBI, and the relationship of those changes to CXCR2 expression ST4.1 Establish spinal cord sites and cell types displaying...we plan to use oral preparations of these drugs and establish dose-response relationships as these will be pharmacologically useful and make the...Anesthesiology Annual Awards Dinner . Palo Alto, CA, June, 2016. 4. Epigenetic Regulation of Chronic Pain after Traumatic Brain Injury. De-Yong

  20. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 58; Issue 5-6. Polarized Raman scattering in single crystals of Nd0.7Sr0.3MnO3. M Pattabiraman G Rangarajan Kwang-Yong Choi P Lemmens G Guentherodt G Balakrishnan D McK Paul M R Less. Colossal Magnetoresistance & Other Materials Volume 58 Issue 5-6 ...

  1. Expansion of Countermine Lidar UAV-based System (CLUBS)

    Science.gov (United States)

    2012-09-30

    Joong Yong Park Optech Inc. 7225 Stennis Airport Drive, Suite 300 Kiln , Mississippi 39556 phone: (228) 252-1004 fax: (228) 252-1007...Suite 300 Kiln , Mississippi 39556 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR...durarion – 1-2.2 ns • Pulse repetition rate – near 2 kHz • Air cooling • Best efficiency (minimum electrical power consumption) • Minimum size 3

  2. Novel method of assessing delamination of the anterior lens capsule using spectral-domain optical coherence tomography

    OpenAIRE

    Tan, Deborah KL; Aung, Tin; Perera, Shamira A

    2012-01-01

    Deborah KL Tan,1 Tin Aung,1–3 Shamira A Perera1,21Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3National University of Singapore, Yong Loo Lin School of Medicine, SingaporeBackground: Delamination of the anterior lens capsule producing a double-ring sign during continuous curvilinear capsulorhexis is commonly associated with true exfoliation syndrome.Methods: Previous studies have concentrated on light- and transmission-electron microscopic...

  3. Changing patient safety culture in China: a case study of an experimental Chinese hospital from a comparative perspective

    OpenAIRE

    Xu XP; Deng DN; Gu YH; Ng CS; Cai X; Xu J; Zhang XS; Ke DG; Yu QH; Chan CK

    2018-01-01

    Xiao Ping Xu,* Dong Ning Deng,* Yong Hong Gu, Chui Shan Ng, Xiao Cai, Jun Xu, Xin Shi Zhang, Dong Ge Ke, Qian Hui Yu, Chi Kuen Chan Clinical Service Department, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China *These authors contributed equally to this work Background: The World Health Organization highlights that patient safety interventions are not lacking but that the local context affects their successful implementation. Increasing att...

  4. Treatment decision-making among breast cancer patients in Malaysia

    OpenAIRE

    Nies YH; Islahudin F; Chong WW; Abdullah N; Ismail F; Ahmad Bustamam RS; Wong YF; Saladina JJ; Mohamed Shah N

    2017-01-01

    Yong Hui Nies,1 Farida Islahudin,1 Wei Wen Chong,1 Norlia Abdullah,2 Fuad Ismail,3 Ros Suzanna Ahmad Bustamam,4 Yoke Fui Wong,5 JJ Saladina,2 Noraida Mohamed Shah1 1Faculty of Pharmacy, 2Department of Surgery, 3Department of Radiotherapy and Oncology, Universiti Kebangsaan Malaysia Medical Centre, 4Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Kuala Lumpur, 5Department of Radiotherapy and Oncology, National Cancer Institute, Putrajaya, Malaysia Purpose: This study investig...

  5. Sociopathic Knowledge Bases: Correct Knowledge Can Be Harmful Even Given Unlimited Computation

    Science.gov (United States)

    1989-08-01

    1757 I Sociopathic Knowledge Bases: Correct Knowledge Can Be Harmful Even Given Unlimited Computation DTIC5 by flELECTE 5David C. Wilkins and Yong...NUMBERSWOKNI PROGRAM RAT TSWOKUI 61153N RR04206 OC 443g-008 11 TITLE (Include Security Classification) Sociopathic Knowledge Bases: Correct Knowledge Can be...probabilistic rules are shown to be sociopathic and so this problem is very widespread. Sociopathicity has important consequences for rule induction

  6. Developing institutional collaboration between Wageningen University and the Chinese Academy of Agricultural Sciences

    OpenAIRE

    Bonnema, A.B.; Lin, Zhai; Qu, Liang; Jacobsen, E.

    2006-01-01

    Scientific co-operation between the Chinese Academy of Agricultural Sciences (CAAS) and Wageningen University (WU) has been underway since 1990, especially in the field of plant sciences. In 2001, CAAS and WU initiated a formal joint PhD training programme to further structure their co-operation. The goals of this co-operation are to: (1) initiate long-term institutional collaboration through capacity building; (2) jointly establish a modern laboratory; (3) jointly develop a cross-cultural sc...

  7. Effects of Estradiol on Post-Traumatic Stress Disorder Symptoms

    Science.gov (United States)

    2010-03-01

    Directed By: T. John Wu, Ph.D. Associate Professor, Department of Obstetrics and Gynecology Post-traumatic stress disorder (PTSD) is a complex...Preventing post-traumatic stress disorder after mass exposure to violence . Biosecur Bioterror 2005;3:154-63; discussion 64-5. 16. Baker DG...John Wu* Affiliations: *Program in Neuroscience and § Program in Molecular and Cellular Biology, Department of Obstetrics and Gynecology Uniformed

  8. New species and new records of Amphinemurinae (Plecoptera: Nemouridae) from Shaanxi Province of China.

    Science.gov (United States)

    Li, Weihai; Dong, Wenbin; Yang, Ding

    2018-03-27

    Three new species of the Amphinemurinae genus Amphinemura, A. dicroidea sp. nov., A. longihamita sp. nov. and A. microhamita sp. nov., are described from China. These new species are compared with related taxa. Amphinemura multispina (Wu) and Sphaeronemoura grandicauda (Wu) (also belonging to the Amphinemurinae) are recorded from Shaanxi Province, northwestern China for the first time. The adult male of A. multispina is redescribed and the adult female of S. grandicauda is also described based on new material.

  9. A comparative survey of the condition of tourism infrastructure in Iranian provinces using VIKOR and TOPSIS

    OpenAIRE

    Moslem Bagheri; Payam Shojaei; Maryam Tayebi Khorami

    2018-01-01

    Tourism infrastructure development in different regions of the world does not follow a symmetrically equal pattern. Because of the importance of infrastructure in the tourism development, the present research is an attempt to examine the hard elements of tourism infrastructure in different provinces of Iran, using the indicators proposed by Pearce and Wu (2015) [Pearce, P. L. & Wu, M. Y. (2015). Soft infrastructure at tourism sites: identifying key issues for Asian tourism from case studies. ...

  10. The efficacy and characteristics of warm-up and re-warm-up practices in soccer players: a systematic review.

    Science.gov (United States)

    Hammami, Amri; Zois, James; Slimani, Maamer; Russel, Mark; Bouhlel, Ezdine

    2018-01-01

    This review aimed 1) to evaluate the current research that examines the efficacy of warm-up (WU) and re-warm-up (RWU) on physical performance; and 2) to highlight the WU and RWU characteristics that optimise subsequent performance in soccer players. A computerized search was performed in the PubMed, ScienceDirect and Google Scholar (from 1995 to December 2015) for English-language, peer-reviewed investigations using the terms "soccer" OR "football" AND "warm-up" OR "stretching" OR "post-activation potentiation" OR "pre-activity" OR "re-warm-up" AND "performance" OR "jump" OR "sprint" OR "running". Twenty seven articles were retrieved. Particularly, 22 articles examined the effects of WU on soccer performance and 5 articles focused on the effects of RWU. Clear evidence exists supporting the inclusion of dynamic stretching or postactivation potentiation-based exercises within a WU as acute performance enhancements were reported (pooled estimate changes of +3.46% and +4.21%, respectively). The FIFA 11+ WU also significantly increases strength, jump, speed and explosive performances (changes from 1% to 20%). At half-time, active RWU protocols including postactivation potentiation practices and multidirectional speed drills attenuate temperature and performance reductions induced by habitual practice. The data obtained in the present review showed that the level of play did not moderate the effectiveness of WU and RWU on soccer performance. This review demonstrated that a static stretching WU reduced acute subsequent performance, while WU activities that include dynamic stretching, PAP-based exercises, and the FIFA 11+ can elicit positive effects in soccer players. The efficacy of an active RWU during half-time is also justified.

  11. Unearthing the Past

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2013-01-01

    Wu Wenguang, considered the father of independent Chinese documentary film, has since 2005 slowly but surely been handing over the camera to people on the margins and to younger generations of Chinese documentary filmmaking. In 2010 Wu and Caochangdi Workstation initiated the Folk Memory Document...... Documentary Project, where young filmmakers go to the countryside to gather and document memories of the Great Famine (1959-1961) from elderly villagers....

  12. 日清戦争後中国女子教育普及に向けた日本教育界の働きかけ : 呉汝綸の日本教育視察(1902)をめぐって

    OpenAIRE

    董, 秋艶; Dong, QiuYan

    2013-01-01

    This paper analyzes the intervention by Japanese educators to spread women's education in China that followed Wu Rulun's observation in Japan. Japanese educators used this opportunity to attempt to introduce Japanese influences into Chinese women's education in the post Sino-Japan War era. Wu made a trip to Japan in order to observe Japanese education and to develop ideas for pending reforms on Chinese women's education. Chapter one reports the Ministry of Education, Science and Culture showi...

  13. An inductive narrow-pulse RFID telemetry system for gastric slow waves monitoring.

    Science.gov (United States)

    Javan-Khoskholgh, Amir; Abukhalaf, Zaid; Ji Li; Miller, Larry S; Kiani, Mehdi; Farajidavar, Aydin

    2016-08-01

    We present a passive data telemetry system for real-time monitoring of gastric electrical activity of a living subject. The system is composed of three subsystems: an implantable unit (IU), a wearable unit (WU), and a stationary unit (SU). Data communication between the IU and WU is based on a radio-frequency identification (RFID) link operating at 13.56 MHz. Since wireless power transmission and reverse data telemetry system share the same inductive interface, a load shift keying (LSK)-based differential pulse position (DPP) coding data communication with only 6.25% duty cycle is developed to guarantee consistent wireless downlink power transmission and uplink high data transfer rate, simultaneously. The clock and data are encoded into one signal by an MSP430 microcontroller (MCU) at the IU side. This signal is sent to the WU through the inductive link, where decoded by an MSP432 MCU. Finally, the retrieved data at the WU are transmitted to the SU connected to a PC via a 2.4 GHz transceiver for real-time display and analysis. The results of the measurements on the implemented test bench, demonstrate IU-WU 125 kb/s and WU-SU 2 Mb/s data transmission rate with no observed mismatch, while the data stream was randomly generated, and matching between the transmitted data by the IU and received by the SU verified by a custom-made automated software.

  14. Uncertainty of Wheat Water Use: Simulated Patterns and Sensitivity to Temperature and CO2

    Science.gov (United States)

    Cammarano, Davide; Roetter, Reimund P.; Asseng, Senthold; Ewert, Frank; Wallach, Daniel; Martre, Pierre; Hatfield, Jerry L.; Jones, James W.; Rosenzweig, Cynthia E.; Ruane, Alex C.; hide

    2016-01-01

    Projected global warming and population growth will reduce future water availability for agriculture. Thus, it is essential to increase the efficiency in using water to ensure crop productivity. Quantifying crop water use (WU; i.e. actual evapotranspiration) is a critical step towards this goal. Here, sixteen wheat simulation models were used to quantify sources of model uncertainty and to estimate the relative changes and variability between models for simulated WU, water use efficiency (WUE, WU per unit of grain dry mass produced), transpiration efficiency (Teff, transpiration per kg of unit of grain yield dry mass produced), grain yield, crop transpiration and soil evaporation at increased temperatures and elevated atmospheric carbon dioxide concentrations ([CO2]). The greatest uncertainty in simulating water use, potential evapotranspiration, crop transpiration and soil evaporation was due to differences in how crop transpiration was modelled and accounted for 50 of the total variability among models. The simulation results for the sensitivity to temperature indicated that crop WU will decline with increasing temperature due to reduced growing seasons. The uncertainties in simulated crop WU, and in particularly due to uncertainties in simulating crop transpiration, were greater under conditions of increased temperatures and with high temperatures in combination with elevated atmospheric [CO2] concentrations. Hence the simulation of crop WU, and in particularly crop transpiration under higher temperature, needs to be improved and evaluated with field measurements before models can be used to simulate climate change impacts on future crop water demand.

  15. Performance-intensity functions of Mandarin word recognition tests in noise: test dialect and listener language effects.

    Science.gov (United States)

    Liu, Danzheng; Shi, Lu-Feng

    2013-06-01

    This study established the performance-intensity function for Beijing and Taiwan Mandarin bisyllabic word recognition tests in noise in native speakers of Wu Chinese. Effects of the test dialect and listeners' first language on psychometric variables (i.e., slope and 50%-correct threshold) were analyzed. Thirty-two normal-hearing Wu-speaking adults who used Mandarin since early childhood were compared to 16 native Mandarin-speaking adults. Both Beijing and Taiwan bisyllabic word recognition tests were presented at 8 signal-to-noise ratios (SNRs) in 4-dB steps (-12 dB to +16 dB). At each SNR, a half list (25 words) was presented in speech-spectrum noise to listeners' right ear. The order of the test, SNR, and half list was randomized across listeners. Listeners responded orally and in writing. Overall, the Wu-speaking listeners performed comparably to the Mandarin-speaking listeners on both tests. Compared to the Taiwan test, the Beijing test yielded a significantly lower threshold for both the Mandarin- and Wu-speaking listeners, as well as a significantly steeper slope for the Wu-speaking listeners. Both Mandarin tests can be used to evaluate Wu-speaking listeners. Of the 2, the Taiwan Mandarin test results in more comparable functions across listener groups. Differences in the performance-intensity function between listener groups and between tests indicate a first language and dialectal effect, respectively.

  16. A Review on Gnetalean Megafossils: Problems and Perspectives

    Directory of Open Access Journals (Sweden)

    Yong Yang

    2010-11-01

    Full Text Available Gnetalean megafossils were accumulated in the last decade. Taxonomic positions of several of Ephedran megafossil species are, however, controversial, resulting in a complicated nomenclature. Liaoxia Z.Y. Cao & S.Q. Wu, “Eragrostis Z.Y. Cao & S.Q. Wu”, “Chaoyangia Duan”, and their type species “Liaoxia cheniae Z.Y. Cao & S.Q. Wu”, “Eragrostis changii Z.Y. Cao & S.Q. Wu”, “Chaoyangia liangii S.Y. Duan”, were not validly published in the original publication under the Vienna Code. The species “Liaoxia cheniae Z.Y. Cao & S.Q. Wu” was validly published as Ephedrites cheniae S.X. Guo & X.W. Wu but later combined into Liaoxia cheniae (S.X. Guo & X.W. Wu Z.Y. Cao & S.Q. Wu and further into Ephedra cheniae (S.X. Guo & X.W. Wu H.M. Liu et al. Some uncertain morphological characters are fundamental to elucidate the taxonomic position of Ephedrites cheniae S.X. Guo & X.W. Wu and “Chaoyangia liangii S.Y. Duan”, e.g. bract number, position, and connation in female cones, seed number and position in a female cone, and morphology of the furcated appendages of reproductive organs of “Chaoyangia liangii S.Y. Duan”.

  17. PREFACE International Symposium on Spintronic Devices and Commercialization 2010

    Science.gov (United States)

    Du, You-wei; Judy, Jack; Qian, Zhenghong; Wang, Jianping

    2011-01-01

    very successful indeed. We are also grateful to the Advisory Committee, the Conference Chairs, the Excutive Chairs, the Academic Committee, the Organization Committee and the Secretariat for their fruitful work. We would especially like to thank all the organizers listed below for their support in all aspects of the conference. We would like to express our thanks to all the authors for their time and genuine efforts, and to the reviewers for their fruitful comments during the preparation of this volume. ISSDC'2010 ORGANIZATION Advisory Committee Chialing Chien, USAJunhao Chu, ChinaBernard Dieny, FranceKoichiro Inomata, Japan Liangmo Mei, ChinaJohn Sivertsen, USAMingjing Tu, ChinaDingsheng Wang, China Zhanguo Wang, ChinaQikun Xue, ChinaWenshan Zhan, China Conference Chairs Jack Judy, USAYouwei Du, China Executive Chairs Zhenghong Qian, USAJianping Wang, USA Organization Committee ChairJiyan Luo, China Vice ChairsGuilin Duan, ChinaLingling Sun, ChinaBaogen Shen, China MembersTiecheng Lu, ChinaDa Ma, ChinaYe Tian, China Jinsong Xu, ChinaQiuling XuChangmao Yang, China Guanghua Yu, ChinaYi Yan, China Academic Committee ChairsZhenghong Qian, USAYongbing Xu, UK Vice ChairsSeongtae Bae, SingaporeYong Jiang, ChinaDexin Wang, USA Huaiwu Zhang, ChinaJianhua Zhao, China MembersJianwang Cai, ChinaXiangdong Chen, ChinaHaifeng Ding, China Chunhong Hou, USAGunther Baubock, USABin Hu, USA Jungchun Huang, TaiwanDexuan Huo, ChinaYoon H Jeong, Korea Chihuang Lai, TaiwanRunwei Li, ChinaWei Liu, China Jing Shi, USAYasushi Takemura, JapanMark Tondra, USA Shan X Wang, USADi Wu, ChinaDesheng Xue, China Minglang Yan, USAShishen Yan, ChinaXiaofei Yang, China Chun Yeol You, KoreaWei Zhao, ChinaShiming Zhou, China Jianguo Zhu, China Secretariat Secretary-generalChangmao Yang, China Vice Secretary-generalJunli Wang, ChinaJinsong Xu, ChinaYe Tian, China MembersRu Bai, ChinaHongliang Zhan, China ISSDC' 2010 Organizers Department of Science and Technology, CSIC, China SpinIC Inc., China Hangzhou

  18. Comparison of the effects of active, passive and mixed warm ups on swimming performance.

    Science.gov (United States)

    Adams, S; Psycharakis, S G

    2014-10-01

    The aim of this paper was to compare the effects of an active (AWU), passive (PWU) and mixed warm up (MWU) on swimming performance. Eight male competitive swimmers completed each type of WU and, following a 20-minute rest, performed a maximum 100m test on their specialised stroke. The order of WUs was randomized and there was a 7-day period between subsequent testing sessions. The time taken to complete the 100m trial was the performance measure. The rating of perceived exertion (RPE) was measured immediately post WU, while heart rate (HR) was measured pre and post WU and pre and post the maximum swim. During the 20-minute rest, the swimmers' psychological state was assessed with the CSAI-2 questionnaire. Post WU HR and RPE had the lowest values following the AWU and the highest values following the PWU (Pperformance HR increased significantly relative to pre WU HR for all conditions (P≤0.01). Swimmers had relatively low levels of anxiety and modest to high levels of self confidence for all conditions. No WU appeared to be superior to the others with respect to swimming performance. The MWU produced nearly identical values to the AWU for most variables, and was therefore found to be an appropriate alternative WU type that swimmers may use before competition. The PWU also seemed to be appropriate, but the somewhat worse performance and lower cognitive anxiety and self confidence scores recorded, albeit non-significant, suggested that more swimmers and distances are tested before any firm conclusions regarding its effectiveness can be drawn.

  19. Effects of general, specific and combined warm-up on explosive muscular performance

    Directory of Open Access Journals (Sweden)

    David Cristobal Andrade

    2015-02-01

    Full Text Available The purpose of this study was to compare the acute effects of general, specific and combined warm-up (WU on explosive performance. Healthy male (n=10 subjects participated in six WU protocols in a crossover randomized study design. Protocols were: passive rest (PR; 15 min of passive rest, running (Run; 5 min of running at 70% of maximum heart rate, stretching (STR; 5 min of static stretching exercise, jumping [Jump; 5 min of jumping exercises – 3x8 countermovement jumps (CMJ and 3x8 drop jumps from 60 cm (DJ60], and combined (COM; protocols Run + STR + Jump combined. Immediately before and after each WU, subjects were assessed for explosive concentric-only (i.e. squat jump – SJ, slow stretch-shortening cycle (i.e. CMJ, fast stretch-shortening cycle (i.e. DJ60 and contact time (CT muscle performance. PR significantly reduced SJ performance (p =0.007. Run increased SJ (p =0.0001 and CMJ (p =0.002. STR increased CMJ (p =0.048. Specific WU (i.e. Jump increased SJ (p =0.001, CMJ (p =0.028 and DJ60 (p =0.006 performance. COM increased CMJ performance (p =0.006. Jump was superior in SJ performance vs. PR (p =0.001. Jump reduced (p =0.03 CT in DJ60. In conclusion, general, specific and combined WU increase slow stretch-shortening cycle (SSC muscle performance, but only specific WU increases fast SSC muscle performance. Therefore, to increase fast SSC performance, specific fast SSC muscle actions must be included during the WU.

  20. Acute and Time-Course Effects of Traditional and Dynamic Warm-Up Routines in Young Elite Junior Tennis Players.

    Directory of Open Access Journals (Sweden)

    Francisco Ayala

    Full Text Available Despite the large number of studies that have examined the acute effects of different warm up modalities (WU on physical performance, none of them have documented the time course of potential performance recovery in tennis players. The aim of this study was twofold: (a to analyze and compare the acute effects of two different WU modalities (traditional WU [TWU] and dynamic WU [DWU] on physical performance (i.e., CMJ, sprint, serve speed and accuracy in elite junior players, as well as (b to monitor the time course of any WU-induced changes after 30 and 60 min of simulated match-play. Twelve junior elite players completed both WUs modalities (TWU and DWU in a counterbalanced order on separate days. In each experimental session, counter movement jump (CMJ, 20-m sprint, tennis serve speed and accuracy tests were performed before (immediately after TWU or DWU during (30 min and after 60 min of a simulated match play. Measures were compared via four factorial (WU intervention and time repeated measures ANOVAs. There were main effects of WU (TWU and DWU throughout the time for all the variables analysed. The results indicate that DWU routine led to significantly faster 20 m sprint times and higher CMJs as well as faster and more accurate tennis serves at both post warm-up and 30 min match-play testing moments in comparison with the scores reported by the TWU routine (p 75-99%. No significant intergroup differences were found at 60-min match-play testing moment in any variable (except for the 20 m sprint. Therefore, the findings of this study recommend for optimal performance in these elite tennis players, DWU routines should be performed prior to formal training and competition rather than TWU routines.

  1. Monographs in Tang Official Historiography: Perspectives from the Technical Treatises of the History of Sui (Sui shu)

    OpenAIRE

    Morgan, Daniel Patrick; Chaussende, Damien

    2018-01-01

    Finished in 656 as part of a larger project, the ten ‘treatises’ (zhi) of the current History of Sui (Sui shu) provide us with histories of such fields of technical knowledge as astronomy, astrology, omenology, economics, law, geography, metrology, and library science covering the five divided and short-lived dynasties, 502–618 CE, that were the predecessors of the Tang. This edited volume brings together young experts in these fields to reflect upon the way that their history has been writte...

  2. Conjugate heat and mass transfer in heat mass exchanger ducts

    CERN Document Server

    Zhang, Li-Zhi

    2013-01-01

    Conjugate Heat and Mass Transfer in Heat Mass Exchanger Ducts bridges the gap between fundamentals and recent discoveries, making it a valuable tool for anyone looking to expand their knowledge of heat exchangers. The first book on the market to cover conjugate heat and mass transfer in heat exchangers, author Li-Zhi Zhang goes beyond the basics to cover recent advancements in equipment for energy use and environmental control (such as heat and moisture recovery ventilators, hollow fiber membrane modules for humidification/dehumidification, membrane modules for air purification, desi

  3. Chinese Medicine Treatment for Afatinib-Induced Paronychia

    Directory of Open Access Journals (Sweden)

    Pei-Yuu Yang

    2017-01-01

    Full Text Available Afatinib (Gilotrif™ is widely used to treat patients with mutant activating epidermal growth factor receptor- (EGFR- dependent lung adenocarcinoma; however, it has various adverse side effects. Here, we report a patient with afatinib-induced paronychia. After Chinese medicine treatment with the well-known anticancer Chinese herbs, Jen-Ren-Hwo-Minq-Saan, and decoction of Ban-Zhi-Lian (Scutellaria barbata with Bai-Hua-She-She-Cao (Hedyotis diffusa Willd, patient’s condition was significantly improved. This shows that these Chinese medicines can not only be used in cancer treatment but also be used in the afatinib-induced paronychia.

  4. Chinese-English Rocketry Dictionary. Volume 3

    Science.gov (United States)

    1979-03-01

    holder; mount ; brace; am; outri•gger ZhiJu substation ; out station; 11 subcontrol office; suboffice; out office; minor office zhikeceng subehell 12... pad 09 tarthuang’e JrI• M’ spring yoke LU tanhuanggang Vr 4i spring steel 11 Lanhuanggang huomen •T• . S (. P•i sprign-s ,eel shutter 12 tanhuanggong...lead; teadin’. tiqi-an 15,2.am f41 ýi IV1 prnrratin’e detmnation ɞ tiqjita --edJin;1, siijian, 41 i Al ] Jillmdern intLerval tipo -n 6113.r1u 41Ff

  5. The effect of calcium infiltration and irradiation treatment on biochemical and physiological aspects during mango storage

    International Nuclear Information System (INIS)

    Deng Qiaobing; Liu Shaode

    1993-01-01

    Zhi Hua Mango (Mangifera indica L.) was treated using calcium infiltration and radiation. Biochemical and physiological aspects during mango storage were researched. The results that the treatment of CaCl 2 with radiation (dose of 0.25 kGy) can retard Malic enzyme activity, and radiation can also cause effects on the transpiration of Ca ++ and release of CO 2 and ethylene. The mango treated with above way is the best one from view of sense organ. However it does not delay maturity of mango to use Ca ++ treatment alone

  6. Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease

    OpenAIRE

    Pan, Weidong; Kwak, Shin; Liu, Yun; Sun, Yan; Fang, Zhenglong; Qin, Baofeng; Yamamoto, Yoshiharu

    2011-01-01

    We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 ( = 5 9 ) or placebo granule ( = 5 6 ) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants ...

  7. 清末民初における『レ・ミゼラブル』の移入と日本 : 陳景韓訳「哀史之一節逸犯」を例として

    OpenAIRE

    梁, 艶; Liang, Yan

    2011-01-01

    Victor Hugo was introduced into China through his Japanese translations. However, the route of the reception of his masterpiece Les Misérables in China has not yet been explained clearly. In this paper, I will take Ai Shi Zhi Yi Jie Yi Fan, a Chinese translation by Chen Jinghan of a part of Les Misérables, as an example to see how Les Misérables was introduced into China. By examining Japanese translations of Les Misérables, I come to the conclusion that Chen was influenced by Kuroiwa Ruikô's...

  8. モンゴル時代の「道仏論争」の実像:クビライの中国支配への道

    OpenAIRE

    中村淳

    1994-01-01

    The disputes between one sect of Taoism Quan-zhen-jiao (全真教) and the Zen sect (禅宗) of Buddhism arose three times in the reign of the Emperor Möngke. According to the Zhi-yuan-bian-wei-lu (至元辯偽録) compiled by a Buddhist monk which have been regarded as the only relevant literature, it is reported that these disputes ended in a victory for Buddhism. As the result of examining relevant parts of a report of mission composed by William of Rubruck and a Tibetan chronicle Hu-lan-deb-ther, we have fou...

  9. Solute carrier transporters: potential targets for digestive system neoplasms

    OpenAIRE

    Xie, Jing; Zhu, Xiao Yan; Liu, Lu Ming; Meng, Zhi Qiang

    2018-01-01

    Jing Xie,1,2 Xiao Yan Zhu,1,2 Lu Ming Liu,1,2 Zhi Qiang Meng1,2 1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China Abstract: Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues o...

  10. Spice and the World

    Institute of Scientific and Technical Information of China (English)

    Yu Xin

    2017-01-01

    Emperor. One inevitable re ̄sult of the importation into China of such huge a ̄mounts of pepper, however, was that hitherto un ̄developed exchange relations improved, though the equilibrium between demand and supply remained unsteady because of obstacles in the way of equita ̄ble distribution. A sudden expansion of the selling market could only be expected to cause a dramatic fall in the price of pepper. This occurred much earlier than did the discovery of the direct passage to India by Vasco de Gama. During the reign of the first Ming Emperor, Hong Wu, pepper and sapanwood were frequently given to subjects as a reward for services rendered, a practice first recorded in 1379 . During 1391 and 1392 , altogether 13 ,800 naval officers and soldiers on active service, and 12,000 soldiers engaged in ship-building were rewarded in this way, the lat ̄ter receiving one catty of pepper each. In both ca ̄ses these rewards, which were small in scale, were for completing tasks assigned. At the time of the enthronement of the second Emperor, Yong Le (1403), four catties of pepper, the highest pepper reward recorded, in addition to 30 ting of paper money, were given to a minor official for comple ̄ting the Imperial seal. Considering the high value of paper money at that time, this showed that pep ̄per was still treasured as a scarce commodity, and had not yet fallen into common use. The effect of Zheng He’s voyages on the distri ̄bution of pepper in the Chinese market is reflected by the form payments took in the early part of the Ming dynasty. In the 5th year of Yong Le (1407), following Zheng He’s return from his first voyage, came the first proclamation of an arrangement to supply the soldiers in all military stations in Peking with sapanwood in lieu of winter clothing. It is es ̄timated that at least 250 , 000 army servicemen were involved. It was in 1420, after Zheng He’s fifth voyage, that pepper was first announced as a substitute for the clothing due to these

  11. Breaking a chaos-based secure communication scheme designed by an improved modulation method

    International Nuclear Information System (INIS)

    Li Shujun; Alvarez, Gonzalo; Chen Guanrong

    2005-01-01

    Recently Bu and Wang [Bu S, Wang B-H. Chaos, Solitons and Fractals 2004;19(4):919-24] proposed a simple modulation method aiming to improve the security of chaos-based secure communications against return-map-based attacks. Soon this modulation method was independently cryptanalyzed by Chee et al. [Chee CY, Xu D, Bishop SR. Chaos, Solitons and Fractals 2004;21(5):1129-34], Wu et al. [Wu X, Hu H, Zhang B. Chaos, Solitons and Fractals 2004;22(2):367-73], and Alvarez et al. [Alvarez G, Montoya F, Romera M, Pastor G. Chaos, Solitons and Fractals, in press, arXiv:nlin/0406065] via different attacks. As an enhancement to the Bu-Wang method, an improving scheme was suggested by Wu et al. by removing the relationship between the modulating function and the zero-points. The present paper points out that the improved scheme proposed by Wu et al. is still insecure against a new attack. Compared with the existing attacks, the proposed attack is more powerful and can also break the original Bu-Wang scheme. Furthermore, it is pointed out that the security of the modulation-based schemes proposed by Wu et al. is not so satisfactory from a pure cryptographical point of view. The synchronization performance of this class of modulation-based schemes is also discussed

  12. Breaking a chaos-based secure communication scheme designed by an improved modulation method

    Energy Technology Data Exchange (ETDEWEB)

    Li Shujun [Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong (China)]. E-mail: hooklee@mail.com; Alvarez, Gonzalo [Instituto de Fisica Aplicada, Consejo Superior de Investigaciones Cientificas, Serrano 144-28006 Madrid (Spain); Chen Guanrong [Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong (China)

    2005-07-01

    Recently Bu and Wang [Bu S, Wang B-H. Chaos, Solitons and Fractals 2004;19(4):919-24] proposed a simple modulation method aiming to improve the security of chaos-based secure communications against return-map-based attacks. Soon this modulation method was independently cryptanalyzed by Chee et al. [Chee CY, Xu D, Bishop SR. Chaos, Solitons and Fractals 2004;21(5):1129-34], Wu et al. [Wu X, Hu H, Zhang B. Chaos, Solitons and Fractals 2004;22(2):367-73], and Alvarez et al. [Alvarez G, Montoya F, Romera M, Pastor G. Chaos, Solitons and Fractals, in press, arXiv:nlin/0406065] via different attacks. As an enhancement to the Bu-Wang method, an improving scheme was suggested by Wu et al. by removing the relationship between the modulating function and the zero-points. The present paper points out that the improved scheme proposed by Wu et al. is still insecure against a new attack. Compared with the existing attacks, the proposed attack is more powerful and can also break the original Bu-Wang scheme. Furthermore, it is pointed out that the security of the modulation-based schemes proposed by Wu et al. is not so satisfactory from a pure cryptographical point of view. The synchronization performance of this class of modulation-based schemes is also discussed.

  13. A weighted U-statistic for genetic association analyses of sequencing data.

    Science.gov (United States)

    Wei, Changshuai; Li, Ming; He, Zihuai; Vsevolozhskaya, Olga; Schaid, Daniel J; Lu, Qing

    2014-12-01

    With advancements in next-generation sequencing technology, a massive amount of sequencing data is generated, which offers a great opportunity to comprehensively investigate the role of rare variants in the genetic etiology of complex diseases. Nevertheless, the high-dimensional sequencing data poses a great challenge for statistical analysis. The association analyses based on traditional statistical methods suffer substantial power loss because of the low frequency of genetic variants and the extremely high dimensionality of the data. We developed a Weighted U Sequencing test, referred to as WU-SEQ, for the high-dimensional association analysis of sequencing data. Based on a nonparametric U-statistic, WU-SEQ makes no assumption of the underlying disease model and phenotype distribution, and can be applied to a variety of phenotypes. Through simulation studies and an empirical study, we showed that WU-SEQ outperformed a commonly used sequence kernel association test (SKAT) method when the underlying assumptions were violated (e.g., the phenotype followed a heavy-tailed distribution). Even when the assumptions were satisfied, WU-SEQ still attained comparable performance to SKAT. Finally, we applied WU-SEQ to sequencing data from the Dallas Heart Study (DHS), and detected an association between ANGPTL 4 and very low density lipoprotein cholesterol. © 2014 WILEY PERIODICALS, INC.

  14. Temperature sensitivity (Q10), and dynamics of soil organic matter (SOM) decomposition in permafrost soils with different carbon quality and under experimental warming. R. Bracho1, E.A.G Schuur1, E. Pegoraro1, K.G. Crummer1, S. Natali2, J. Zhou, Y Luo3, J. L. Wu3, M. Tiedje4, K. Konstantinidis5 1Department of Biology, University of Florida, Gainesville, FL. 2Woods Hole Research Center, Falmouth, MA. 3Institute for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, OK, 4Center for Microbial Ecology, Michigan State University, East Lansing, MI; 5Center for Bioinformatics and Computational Genomics and School of Biology, Georgia Institute of Technology, Atlanta, GA

    Science.gov (United States)

    Bracho, R. G.; Schuur, E. A.; Pegoraro, E.; Crummer, K. G.; Natali, S.; Zhou, J.; Wu, L.; Luo, Y.; Tiedje, J. M.; Konstantinidis, K.

    2013-12-01

    Permafrost soils contain approximately1700 Pg of carbon (C), twice the amount of C in the atmosphere. Temperatures in higher latitudes are increasing, inducing permafrost thaw and subsequent microbial decomposition of previously frozen C. This process is one of the most likely positive feedbacks to climate change. Understanding the temperature sensitivity (Q10) and dynamics of SOM decomposition under warming is essential to predict the future state of the earth - climate system. Alaskan tundra soils were exposed to two winter warming (WW) seasons in the field, which warmed the soils by 4°C to 40 cm depth. Soils were obtained from three depths (0 - 15, 15 - 25 and 45 - 55 cm) and differed in initial amounts of labile and recalcitrant C. Soils were incubated in the lab under aerobic conditions, at 15 and 25°C over 365 days. Q10 was estimated at 14, 100 & 280 days of incubation (DOI); C fluxes were measured periodically and dynamics of SOM decomposition (C pool sizes and decay rates) were estimated by fitting a two pool C model to cumulative respired C (Ccum, mgC/ginitialC). After two WW seasons, initial C content tended to decrease through the soil profile and C:N ratio was significantly decreased in the top 15 cm. After one year of incubation, Ccum was twice as high at 25°C as at 15°C and significantly decreased with depth. No significant WW field treatment was detected, although Ccum tended to be lower in warmed soils. Labile C accounted for up to 5% of initial soil C content in the top 15 cm and decreased with depth. Soils exposed to WW had smaller labile C pools, and higher labile C decay rates in the top 25 cm. Q10 significantly decreased with time and depth as labile pool decreased, especially for WW. This decrease with time indicates a lower temperature sensitivity of the most recalcitrant C pool. The deepest WW soil layer, where warming was more pronounced, had significantly lower Q10 compared to control soils at the same depth. After two seasons, the warming treatment affected decomposition by reducing labile C pools and increasing its decay rates. Warming also reduced temperature sensitivity, showing acclimation of the most recalcitrant C pool in the tundra ecosystem.

  15. Avatar' remarks on the carbon input threshold in the sloping croplands

    Science.gov (United States)

    Novara, Agata; Gristina, Luciano; García-Díaz, Andrés; Menghin, Riccardo; Cerdà, Artemi

    2015-04-01

    ., Santoro, A. and Cerdà, A. 2013. Managing soil nitrate with cover crops and buffer strips in Si cilian vineyards. Solid Earth, 4, 255-262. DOI:10.5194/se-4-255-2013. Q. Y. Li, H. Y. Fang, L. Y. Sun and Q. G. Cai 2014 USING THE 137Cs TECHNIQUE TO STUDY THE EFFECT OF SOIL REDISTRIBUTION ON SOIL ORGANIC CARBON AND TOTAL NITROGEN STOCKS IN AN AGRICULTURAL CATCHMENT OF NORTHEAST CHINA Land Degradation and development 25 350-359 DOI: 10.1002/ldr.2 R. C. Fialho and Y. L. Zinn 2014. CHANGES IN SOIL ORGANIC CARBON UNDER EUCALYPTUS PLANTATIONS IN BRAZIL: A COMPARATIVE ANALYSIS. Land Degradation and Development, 25, 428-437. | DOI: 10.1002/ldr.2158 Yan-Gui, S., Xin-Rong, L., Ying-Wu, C., Zhi-Shan, Z., and Yan, L. 2013. Carbon fixaton of cyanobacterial-algal crusts after desert fixation and its implication to soil organic matter accumulation in Desert. Land Degradation & Development, 24: 342- 349. DOI 10.1002/ldr.1131 Zhao, G., Mu, X., Wen, Z., Wang, F., and Gao, P. Soil erosion, conservation, and Eco-environment changes in the Loess Plateau of China. Land Degradation & Development, 24: 499- 510. 2013. DOI 10.1002/ldr.2246

  16. EDITORIAL: Focus on Quantum Cryptography: Theory and Practice FOCUS ON QUANTUM CRYPTOGRAPHY: THEORY AND PRACTICE

    Science.gov (United States)

    Lütkenhaus, N.; Shields, A. J.

    2009-04-01

    descriptions and are based on observable tests during the run of QKD sessions. It is now 25 years since the first proposal for QKD was published and 20 since the first experimental realization. The intervening years have brought several technological and theoretical advances, which have driven new insights into the application of quantum theory to the wider field of information technology. We are looking forward to the new twists and turns this field will take in the next 25 years! Focus on Quantum Cryptography: Theory and Practice Contents Security of continuous-variable quantum key distribution: towards a de Finetti theorem for rotation symmetry in phase space A Leverrier, E Karpov, P Grangier and N J Cerf Optical networking for quantum key distribution and quantum communications T E Chapuran, P Toliver, N A Peters, J Jackel, M S Goodman, R J Runser, S R McNown, N Dallmann, R J Hughes, K P McCabe, J E Nordholt, C G Peterson, K T Tyagi, L Mercer and H Dardy Proof-of-concept of real-world quantum key distribution with quantum frames I Lucio-Martinez, P Chan, X Mo, S Hosier and W Tittel Composability in quantum cryptography Jörn Müller-Quade and Renato Renner Distributed authentication for randomly compromised networks Travis R Beals, Kevin P Hynes and Barry C Sanders Feasibility of 300 km quantum key distribution with entangled states Thomas Scheidl, Rupert Ursin, Alessandro Fedrizzi, Sven Ramelow, Xiao-Song Ma, Thomas Herbst, Robert Prevedel, Lothar Ratschbacher, Johannes Kofler, Thomas Jennewein and Anton Zeilinger Decoy-state quantum key distribution with both source errors and statistical fluctuations Xiang-Bin Wang, Lin Yang, Cheng-Zhi Peng and Jian-Wei Pan High rate, long-distance quantum key distribution over 250 km of ultra low loss fibres D Stucki, N Walenta, F Vannel, R T Thew, N Gisin, H Zbinden, S Gray, C R Towery and S Ten Topological optimization of quantum key distribution networks R Alléaume, F Roueff, E Diamanti and N Lütkenhaus The SECOQC quantum key

  17. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    Science.gov (United States)

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  18. Implementation of envelope detection based Wake-Up Receiver for IEEE 802.15.4 WPAN from off-the-shelf components

    Science.gov (United States)

    Arndt, Josua; Krystofiak, Lukas; Bonehi, Vahid; Wunderlich, Ralf; Heinen, Stefan

    2017-09-01

    Power consumption in wireless networks is crucial. In most scenarios the transmission time is short compared to the idle listening time for data transmission, the most power is consumed by the receiver. In low latency systems there is a need for low power wake-up receivers (WuRx) that reduce the power consumption when the node is idle, but keep it responsive. This work presents a WuRx designed out of commercial components to investigate the needs of a WuRx when it is embedded in a Wireless Personal Area Network (WPAN) system in a real environment setup including WLAN and LTE communication and considering interferer rejection. The calculation necessary for the attenuation of those interferers is explained in detail. Furthermore, a system design is presented that fulfills the requirements for this environment and is build from off-the-shelf components.

  19. Stochastic spin-one massive field

    International Nuclear Information System (INIS)

    Lim, S.C.

    1984-01-01

    Stochastic quantization schemes of Nelson and Parisi and Wu are applied to a spin-one massive field. Unlike the scalar case Nelson's stochastic spin-one massive field cannot be identified with the corresponding euclidean field even if the fourth component of the euclidean coordinate is taken as equal to the real physical time. In the Parisi-Wu quantization scheme the stochastic Proca vector field has a similar property as the scalar field; which has an asymptotically stationary part and a transient part. The large equal-time limit of the expectation values of the stochastic Proca field are equal to the expectation values of the corresponding euclidean field. In the Stueckelberg formalism the Parisi-Wu scheme gives rise to a stochastic vector field which differs from the massless gauge field in that the gauge cannot be fixed by the choice of boundary condition. (orig.)

  20. Root growth of Cynodon dactylon and Eleusine indica collected from motorways at different concentrations of lead.

    Science.gov (United States)

    Wong, M H; Lau, W M

    1985-04-01

    An ecological survey was conducted on the roadside vegetation at three different sites: Tai Po, a commercial and residential area (average annual daily traffic (AADT) = 23730; and Shek O and Wu Kai Sha, recreational areas (AADT = 1590 and 20, respectively). Cynodon dactylon and Eleusine indica were the two most dominant species recorded. The Tai Po site had higher Pb contents in both soil and plant, followed by Shek O, and then Wu Kai Sha. Tillers of C. dactylon and E. indica from the three sites were subjected to a series concentrations of Pb(NO3)2. By comparing their indexes of tolerance and values of 14-day EC50 (effective concentration reducing the normal root growth by 50%), roadside populations of the two grasses collected from Tai Po and Shek O, especially the former one, were more tolerant to elevated levels of Pb compared with those collected from Wu Kai Sha.

  1. Effects of Huang Bai (Phellodendri Cortex and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells

    Directory of Open Access Journals (Sweden)

    Sun Haeng Lee

    2016-01-01

    Full Text Available The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 μg/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only, or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary.

  2. Radiotherapy-related typing in 842 patients in canton with nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Li Zhiqiang; Xia Yunfei; Liu Qing; Yi, Wei; Liu Xiufang; Han Fei; Luo Wei; Lu Taixiang

    2006-01-01

    Purpose: The aim of this study was to propose the clinical radiotherapy-related typing and to summarize proportional distribution of radiotherapy-related types of nasopharyngeal carcinoma (NPC). Methods and Materials: A total of 842 cases of NPC were randomly selected. According to 5-year follow-up results after radiotherapy, NPC was subdivided into four types: Type I (no primary and regional recurrence and no distant metastasis), Type II (primary or regional recurrence and no distant metastasis), Type III (no primary and regional recurrence, and distant metastasis), and Type IV (primary or regional recurrence, and distant metastasis). Proportion of the four types and relationship between this typing and Zhi-guang Xie typing were analyzed. Results: Distribution of radiotherapy-related types of NPC were 50.6%, 23.2%, 20.7%, and 5.6% for Types I, II, III, and IV, respectively. For Types D and AD of Zhi-guang Xie typing system and Stage III and IV of the 1992 Fuzhou staging system, the proportion of Type III was greater than that of Type II; and for Type A and Stage I and II, there was a larger proportion of Type II than that of Type III. Conclusion: Radiotherapy-related typing, as a new clinical subclassification, could be supplementary for previous clinical typing and staging

  3. Multimedia over cognitive radio networks algorithms, protocols, and experiments

    CERN Document Server

    Hu, Fei

    2014-01-01

    PrefaceAbout the EditorsContributorsNetwork Architecture to Support Multimedia over CRNA Management Architecture for Multimedia Communication in Cognitive Radio NetworksAlexandru O. Popescu, Yong Yao, Markus Fiedler , and Adrian P. PopescuPaving a Wider Way for Multimedia over Cognitive Radios: An Overview of Wideband Spectrum Sensing AlgorithmsBashar I. Ahmad, Hongjian Sun, Cong Ling, and Arumugam NallanathanBargaining-Based Spectrum Sharing for Broadband Multimedia Services in Cognitive Radio NetworkYang Yan, Xiang Chen, Xiaofeng Zhong, Ming Zhao, and Jing WangPhysical Layer Mobility Challen

  4. MiniBooNE Neutrino Physics at the University of Alabama

    International Nuclear Information System (INIS)

    Stancu, Ion

    2007-01-01

    This report summarizes the activities conducted by the UA group under the auspices of the DoE/EPSCoR grant number DE--FG02--04ER46112 since the date of the previous progress report, i.e., since November 2005. It also provides a final report of the accomplishments achieved during the entire period of this grant (February 2004 to January 2007). The grant has fully supported the work of Dr. Yong Liu (postdoctoral research assistant -- in residence at Fermilab) on the MiniBooNE reconstruction and particle identification (PID) algorithms.

  5. Convergence Theorem for Equilibrium and Variational Inequality Problems and a Family of Infinitely Nonexpansive Mappings in Hilbert Space

    Directory of Open Access Journals (Sweden)

    Zhou Yinying

    2014-01-01

    Full Text Available We introduce a hybrid iterative scheme for finding a common element of the set of common fixed points for a family of infinitely nonexpansive mappings, the set of solutions of the varitional inequality problem and the equilibrium problem in Hilbert space. Under suitable conditions, some strong convergence theorems are obtained. Our results improve and extend the corresponding results in (Chang et al. (2009, Min and Chang (2012, Plubtieng and Punpaeng (2007, S. Takahashi and W. Takahashi (2007, Tada and Takahashi (2007, Gang and Changsong (2009, Ying (2013, Y. Yao and J. C. Yao (2007, and Yong-Cho and Kang (2012.

  6. Investigating AAK1-and GAK-Regulated Virus-Host Interactions Uncovers Broad-Spectrum Antivirals

    Science.gov (United States)

    2017-02-16

    AP1) and AP2M1 (AP2) were 527 selected from the Human ORFeome library of cDNA clones (65) (Open Biosystems) and 528 recombined into either pCherry...TSV01 Renilla reporter plasmid was a gift from Pei-Yong Shi (68). 534 Lentiviral constructs used for AP2 overexpression were cloned into the pRRLSIN...681 total of 10 days and observed daily for 28 days for lethality or clinical signs of disease. 682 683 Animal study approval/ Ethics Statement

  7. A valuation method on physiological functionality of food materials

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-10-15

    This reports is about valuation method on physiological functionality of food materials. It includes ten reports: maintenance condition of functional foods in Korea by Kim, Byeong Tae, management plan and classification of functional foods by Jung, Myeong Seop, measurement method vitality of functional foods for preventing diabetes, measurement way of aging delayed activation by Lee, Jae Yong, improvement on effectiveness of anti hypertension by functional foods by Park, Jeon Hong, and practice case for the method of test on anti gastritis antiulcer by Lee, Eun Bang.

  8. A valuation method on physiological functionality of food materials

    International Nuclear Information System (INIS)

    2001-10-01

    This reports is about valuation method on physiological functionality of food materials. It includes ten reports: maintenance condition of functional foods in Korea by Kim, Byeong Tae, management plan and classification of functional foods by Jung, Myeong Seop, measurement method vitality of functional foods for preventing diabetes, measurement way of aging delayed activation by Lee, Jae Yong, improvement on effectiveness of anti hypertension by functional foods by Park, Jeon Hong, and practice case for the method of test on anti gastritis antiulcer by Lee, Eun Bang.

  9. Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

    OpenAIRE

    Li, Feng; Chen, Yan; Liu, Shubo; Qi, Jian; Wang, Weiying; Wang, Chenhua; Zhong, Ruiyue; Chen, Zhijun; Li, Xiaoming; Guan, Yuanzhou; Kong, Wei; Zhang, Yong

    2017-01-01

    Feng Li,1 Yan Chen,1,2 Shubo Liu,1 Jian Qi,1 Weiying Wang,1 Chenhua Wang,1 Ruiyue Zhong,1 Zhijun Chen,1 Xiaoming Li,1 Yuanzhou Guan,1 Wei Kong,1,2 Yong Zhang1,2 1National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 2Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China Abstract: Zein-based nano/microparticles have been demonstrated to be promising carr...

  10. Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

    OpenAIRE

    Oh, Keun Sang; Kim, Kyungim; Yoon, Byeong Deok; Lee, Hye Jin; Park, Dal Yong; Kim, Eun-yeong; Lee, Kiho; Seo, Jae Hong; Yuk, Soon Hong

    2016-01-01

    Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, n...

  11. Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

    OpenAIRE

    Zhao,JiHui; Zhang,Qi-Bo; Liu,Bao; Piao,Xiang-Hua; Yan,Yu-Lu; Hu,Xiao-Ge; Zhou,Kuan; Zhang,Yong-Tai; Feng,Nian-Ping

    2017-01-01

    Ji-Hui Zhao,1,* Qi-Bo Zhang,1,* Bao Liu,2 Xiang-Hua Piao,1 Yu-Lu Yan,1 Xiao-Ge Hu,1 Kuan Zhou,1 Yong-Tai Zhang,1 Nian-Ping Feng1 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Anethesiology Department, Augusta University, Augusta, GA, USA *These authors contributed equally to this work Purpose: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a ...

  12. Metáforas y pensamiento matemático en la formación de educadoras de párvulos

    Directory of Open Access Journals (Sweden)

    Gina Luci Arriagada

    2017-09-01

    Full Text Available ABSTRACT This paper describes the metaphorical approach and how it relates to the development of mathematical thinking, to make improvements in the training of nursery educators. We present an experience with the Shao Yong square, which allows the integration of the metaphorical approach with the development of mathematical thinking, where we study the construction of the concept number with nursery school educators. The proposal highlights methodological strategies and provides as a framework for reading, discussing and pedagogical reflection. Information is provided for innovative classroom teachers of classroom fostering the understanding and teaching of mathematics. Keywords:

  13. Comparison of Three Methods for Generating Superhydrophobic, Superoleophobic Nylon Nonwoven Surfaces (Postprint)

    Science.gov (United States)

    2011-04-01

    film and onto a 100 g/ m2 nylon nonwoven substrate was carried out in a cylindri- cal , inductively coupled plasma reactor (10 cm diameter and 2700 cm3...the Nonwoven Institute (NI) for sharing hydro- entangled nonwoven fabric with us. References 1. Barthlott W, Neinhuis C (1997) Planta 202:1 2. Wu X...Faraday Soc 40:546 8. Lee H (2009) J Mater Sci 44:4645. doi:10.1007/s10853-009- 3711-5 9. Hoefnagels H, Wu D, de With G, Ming W (2007) Langmuir 23

  14. People’s Republic of China Scientific Abstracts No. 164.

    Science.gov (United States)

    1977-02-23

    of these articles. CONTENTS PAGE K’ O-HSUEH SHIH-YEN /SCIENTIFIC EXPERIMENT/ No 8, Äug 76 1 CHIH-WU HSUEH-PAO /ÄCTA BOTANICA SINICA/ Vol 18, No...AUTHOR: None ORG: Digital Control Teaching Group, Shanghai Sparetime Industrial University TITLE: "On the Principles of Digital Machine Tool Control...8217 College" SOURCE: Peking CHIH-WU HSUEH-PAO [AGTA BOTANICA SINICA] Vol 18 No 3, Sep 76 pp 198-201 EXCERPT OF ENGLISH ABSTRACT: The May-7 Agricultural

  15. People’s Republic of China Scientific Abstracts No. 180

    Science.gov (United States)

    1977-11-25

    translations of these articles. CONTENTS PAGE CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] No 1, March 1977 1 K’UN-CH’UNG HSUEH-PAO [ACTA ENTOMOLOGICA...March 1977. 28 TUNG-WU HSUEH-PAO [ACTA ZOOLOGICA SINICA] No 2, June.1977 41 a - [III - CC - 70 S § T] ACTA BOTANICA SINICA AUTHOR...HSUEH-PAO [ACTA BOTANICA SINICA] in Chinese Vol 19 No 1, Mar 77 pp 7-10 TEXT OF ENGLISH ABSTRACT: In 1964, we some young teachers and students in

  16. People’s Republic of China Scientific Abstracts, Number 201

    Science.gov (United States)

    1978-10-24

    original source materials or information as to the availability of full translations of these articles. CONTENTS PAGE CHIH-WU HSUEH-PAO [ACTA BOTANICA ...III - CC - 70 S § T] ACTA BOTANICA 5INICA AUTHOR: TS’AI Ch’i-kuei (5591 6386 6311 ] CH’IEN Ying-ch’ien [6929 66Q1 0241J CHDU...the Isolation and Culture of Rice (Qrvza sativa L.) Protoplasts" SOURCE: Peking CHIH-WU HSUEH-PA0 [ACTA BOTANICA SINICAj in Chinese No 2, Jun 78 pp

  17. People’s Republic of China Scientific Abstracts, Number 195.

    Science.gov (United States)

    1978-08-01

    76 15 CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] No 1, March 1978 16 TI-CHEN CHAN-HSIEN [EARTHQUAKE FRONT] No 2, April 1978 26 K𔃺-HSUEH...steril^UMs! and Consolidate the contradiction between the hsien and 6168 CSO: 8111/1528 15 ACTA BOTANICA SINICA AUTHOR: CHANG Te-i [l72B 1795...of Cultured Tobacco Cells" SOURCE: Peking CHIH-WU H5UEH-PA0 [_ACTA BOTANICA SINICÄ] in Chinese No 1, Mar 78 pp 1-5 TEXT OF ENGLISH ABSTRACT

  18. People’s Republic of China Scientific Abstracts, Number 185

    Science.gov (United States)

    1978-02-14

    CONTENTS PAGE HANG-K’UNG CHIH-SHIH [AERONAUTICAL KNOWLEDGE] No 10, October 1977 .... 1 CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] No 3, September 1977 8...launch units; 3) Chairman Hua visiting an earthquake damaged region; 4) a group of female pilots of a minority race. 3012 CSO: 4009 ACTA BOTANICA ...CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICä] in Chinese Vol 19 No 3, Sep 77 pp 167-171 TEXT OF ENGLISH ABSTRACT: 1. The process of microsporogenesis

  19. On the security of a novel probabilistic signature based on bilinear square Diffie-Hellman problem and its extension.

    Science.gov (United States)

    Zhao, Zhenguo; Shi, Wenbo

    2014-01-01

    Probabilistic signature scheme has been widely used in modern electronic commerce since it could provide integrity, authenticity, and nonrepudiation. Recently, Wu and Lin proposed a novel probabilistic signature (PS) scheme using the bilinear square Diffie-Hellman (BSDH) problem. They also extended it to a universal designated verifier signature (UDVS) scheme. In this paper, we analyze the security of Wu et al.'s PS scheme and UDVS scheme. Through concrete attacks, we demonstrate both of their schemes are not unforgeable. The security analysis shows that their schemes are not suitable for practical applications.

  20. Ultrafast Optics: Vector Cavity Laser - Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  1. Ultrafast Optics - Vector Cavity Lasers: Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  2. Wu’s algorithm and its possible application in cryptanalysis

    CSIR Research Space (South Africa)

    Grobler, TL

    2012-01-01

    Full Text Available now classic book Differential Algebra: Ritt (1950). Later it was independently rediscovered and improved by the Chinese mathematician Wu Wen-Ts?n in the late seventies (Wen-Ts?n, 1978, 1984, 1986). Other resources describing Wu?s algorithm... set that is constructed from a polynomial set so that the characteristic set shares some of the properties of the original set (Gallo and Mishra, 1990b; Ritt, 1950). The algorithm has found wide usage in mechanical theorem proving (Wen-Ts?n, 1986...

  3. Ultrafast Optics: Vector Cavity Fiber Lasers - Physics and Technology

    Science.gov (United States)

    2016-06-14

    with a quasi- vector cavity both numerically and experimentally. It is expected that through the study a deep and comprehensive understanding on the...799-801, Jun. 1997. 31. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like pulse in a gain-guided soliton fiber laser," Opt...solitons in a ring fiber laser," Optics Communications 281 (22), 5614 (2008). 110. L. M. Zhao, D. Y. Tang, J. Wu, X. Q. Fu, and S. C. Wen , "Noise-like

  4. A review of the genus Saccharicoccus Ferris, 1950 (Hemiptera: Coccomorpha: Pseudococcidae) in China, with description of a new species.

    Science.gov (United States)

    Zhang, Jiang-Tao; Wu, Bo-Wen; Wu, San-An

    2018-01-23

    The mealybug genus Saccharicoccus Ferris includes three species: S. isfarensis (Borchsenius, 1949), S. sacchari (Cockerell, 1895) and a new species, S. chinensis Zhang, Wu Wu sp. n. The new species, collected on Miscanthus sp. (Poaceae) and other poaceous weeds in China, is described and illustrated, and molecular analyses based on the mitochondrial gene cytochrome c oxidase subunit I (COI) are provided. Additional data on the distribution and host-plants of each species are given, and a key to the adult females of Saccharicoccus species is provided.

  5. Stoneflies of the genus Neoperla (Plecoptera, Perlidae from Wuyi Mountain National Nature Reserve, Fujian of China

    Directory of Open Access Journals (Sweden)

    Xue-Feng Qin

    2013-08-01

    Full Text Available The species of the genus Neoperla are reviewed from Wuyi Mountain National Nature Reserve located in the Fujian Province of southeastern China, including the description of a new species, Neoperla brevistyla sp. n. The new species is compared to similar taxa. The first records of five Neoperla species, N. henana Li, Wu & Zhang, 2011, N. similiserecta Wang & Li, 2012, N. qingyuanensis Yang & Yang, 1995, N. xuansongae Li & Li, 2013 and N. tuberculata Wu, 1938 are given for the Wuyi Mountain. A provisional key is provided for facilitating the identification of these species.

  6. Stoneflies of the genus Neoperla (Plecoptera, Perlidae) from Wuyi Mountain National Nature Reserve, Fujian of China.

    Science.gov (United States)

    Qin, Xue-Feng; Murányi, Dávid; Wang, Guo-Quan; Li, Wei-Hai

    2013-01-01

    The species of the genus Neoperla are reviewed from Wuyi Mountain National Nature Reserve located in the Fujian Province of southeastern China, including the description of a new species, Neoperla brevistyla sp. n. The new species is compared to similar taxa. The first records of five Neoperla species, Neoperla henana Li, Wu & Zhang, 2011, Neoperla similiserecta Wang & Li, 2012, Neoperla qingyuanensis Yang & Yang, 1995, Neoperla xuansongae Li & Li, 2013 and Neoperla tuberculata Wu, 1938 are given for the Wuyi Mountain. A provisional key is provided for facilitating the identification of these species.

  7. Development of a General Conceptual-numerical Model to Simulate the Fate and Subsurface Transport of Explosives, and the Moisture and Temperature Signatures Around Land Mines

    Science.gov (United States)

    2008-12-01

    Chen, J. Gan, J. Šimůnek, A. C. Chang, and L. Wu, Leaching risk of N-nitrosodimethylamine ( NDMA ) in soil receiving reclaimed wastewater, Highlighted...Abstracts, published on a CD-ROM as abstract 5043, ASA, Madison, 2005. Haruta, S., J. Gan, and J. Šimunek, Numerical Analyses of NDMA Leaching Risk in...Gan, J. Šimůnek, A. C. Chang, and L. Wu, Leaching risk of N- nitrosodimethylamine ( NDMA ) in soil receiving reclaimed wastewater, Highlighted article

  8. Temperature Dependent Rubidium Helium Line Shapes and Fine Structure Mixing Rates

    Science.gov (United States)

    2015-09-01

    tube biased at 1,275 V exhibited a dark signal bias of 4-6 nA with noise fluctuation of 0.04 nA, as monitored on a Keithley model 386 picoammeter with...Journal of Physical Chemistry, 74(1):187–196, 1970. [79] Wu, Sheldon SQ, Thomas F Soules , Ralph H Page, Scott C Mitchell, V Keith Kanz, and Raymond J...Society for Optics and Photonics, 2008. [80] Wu, Sheldon SQ, Thomas F Soules , Ralph H Page, Scott C Mitchell, V Keith Kanz, and Raymond J Beach

  9. Temperature Dependent Rubidium-Helium Line Shapes and Fine Structure Mixing Rates

    Science.gov (United States)

    2015-09-17

    tube biased at 1,275 V exhibited a dark signal bias of 4-6 nA with noise fluctuation of 0.04 nA, as monitored on a Keithley model 386 picoammeter with...Journal of Physical Chemistry, 74(1):187–196, 1970. [79] Wu, Sheldon SQ, Thomas F Soules , Ralph H Page, Scott C Mitchell, V Keith Kanz, and Raymond J...Society for Optics and Photonics, 2008. [80] Wu, Sheldon SQ, Thomas F Soules , Ralph H Page, Scott C Mitchell, V Keith Kanz, and Raymond J Beach

  10. Traitement du signal à temps continu dans le domaine digital pour des wake-up radios

    OpenAIRE

    Ratiu , Alin

    2015-01-01

    Wake-Up Receivers (WU-RX) have been recently proposed as candidates to reduce the communication power budget of wireless networks. Their role is to sense the environment and wake up the main receivers which then handle the bulk data transfer. Existing WU-RXs achieve very high sensitivities for power consumptions below 50uW but severely degrade their performance in the presence of out-of-band blockers. We attempt to tackle this problem by implementing an ultra low power, tunable, intermediate ...

  11. From the transnational to the Sinophone: lesbian representations in Chinese-language films.

    Science.gov (United States)

    Wong, Alvin Ka Hin

    2012-01-01

    This article theorizes global lesbian cinema in Chinese-language films through regionalism, diaspora studies, and Sinophone studies. Through an inter-regional analysis of Butterfly (Yan Yan Mak, 2004, Hong Kong) and diasporic and Sinophone readings of Saving Face (Alice Wu, 2005, USA), I argue that Mak's film illustrates a Hong Kong regional retranslation of a Taiwanese lesbian story, which complicates any claim to a stable "Chinese" identity. Finally, Wu's representation of lesbianism also troubles the politics of Chineseness by pointing to the ways diasporic reproduction of "community" works through the disciplining of other non-normative sexualities.

  12. Global existence of periodic solutions on a simplified BAM neural network model with delays

    International Nuclear Information System (INIS)

    Zheng Baodong; Zhang Yazhuo; Zhang Chunrui

    2008-01-01

    A simplified n-dimensional BAM neural network model with delays is considered. Some results of Hopf bifurcations occurring at the zero equilibrium as the delay increases are exhibited. Global existence of periodic solutions are established using a global Hopf bifurcation result of Wu [Wu J. Symmetric functional-differential equations and neural networks with memory. Trans Am Math Soc 1998;350:4799-838], and a Bendixson criterion for higher dimensional ordinary differential equations due to Li and Muldowney [Li MY, Muldowney J. On Bendixson's criterion. J Differ Equations 1994;106:27-39]. Finally, computer simulations are performed to illustrate the analytical results found

  13. Enhanced Performance & Functionality of Tunable Delay Lines

    Science.gov (United States)

    2012-08-01

    Based Tunable Optical Delays”, Optics Letters, Vol. 33, Issue 13, pp. 1518-1520 (2008). 2. Louis Christen, Irfan Fazal , Omer F. Yilmaz, Xiaoxia Wu...2008. 3. Omer F. Yilmaz, Louis Christen, Xiaoxia Wu, Scott R. Nuccio, Irfan Fazal , and Alan E. Willner, “Time-Slot-Interchange of 40 Gb/s Variable...F. Yilmaz, S. Khaleghi, L. Christen, I. Fazal , and A. E. Willner, “503 ns, Tunable Optical Delay of 40 Gb/s RZ-OOK using Additional λ-Conversion

  14. Five newly recorded Cyprinid fish (Teleostei: Cypriniformes) in Myanmar

    Science.gov (United States)

    Qin, Tao; Chen, Zhi-Ying; Xu, Lu-Lu; Zaw, Paing; Kyaw, Yunn Mi Mi; Maung, Kyaw Win; Chen, Xiao-Yong

    2017-01-01

    Freshwater fish from the Putao and Myitkyina areas were collected in three ichthyofaunal surveys of the Mali Hka River and tributaries in and around Khakaborazi National Park and Hponkanrazi Wildlife Sanctuary, Kachin State, from 2014-2016. Tor yingjiangensis Chen et Yang 2004, Tor qiaojiensis Wu et al. 1977, Garra qiaojiensis Wu et al. 1977, Garra bispinosa Zhang 2005, and Schizothorax oligolepis Huang 1985, originally described from the upper Irrawaddy (Ayeyarwaddy) River in China, are first reported herein as new records to Myanmar. Counts, measurements, descriptions, photographs, and distributions of the specimens of the five newly recorded species are provided. PMID:29181904

  15. MATHEMATICS OF SENSING, EXPLOITATION, AND EXECUTION (MSEE) Sensing, Exploitation, and Execution (SEE) on a Foundation for Representation, Inference, and Learning

    Science.gov (United States)

    2016-07-01

    Automation (ICRA), 2016. [50]. Y. Lu, S.C. Zhu and Y.N. Wu, Learning FRAME Models Using CNN Filters, 30th AAAI Conference on Artificial Intelligence ...Method Cross-Subject Cross-View Cross-Environment Virtual View 0.507 0.478 0.274 Hankelet 0.542 0.452 0.286 Action Bank 0.246 0.176 N/A Poselet... Intelligence , vol. 34, no.7, 1354-1367, 2012. [3]. N. Jiang, W. Liu and Y. Wu, “Order Determination and Sparsity-Regularized Metric Learning for Adaptive

  16. Stochastic quantization and gauge-fixing of the linearized gravitational field

    International Nuclear Information System (INIS)

    Hueffel, H.; Rumpf, H.

    1984-01-01

    Due to the indefiniteness of the Euclidean gravitational action the Parisi-Wu stochastic quantization scheme fails in the case of the gravitational field. Therefore we apply a recently proposed modification of stochastic quantization that works in Minkowski space and preserves all the advantages of the original Parisi-Wu method; in particular no gauge-fixing is required. Additionally stochastic gauge-fixing may be introduced and is also studied in detail. The graviton propagators obtained with and without stochastic gauge-fixing all exhibit a noncausal contribution, but apart from this effect the gauge-invariant quantities are the same as those of standard quantization. (Author)

  17. Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury

    Science.gov (United States)

    2013-03-01

    injury in U.S. military personnel. N Engl J Med 364, 2091–2100 (2011) 27. Lu J, Ng KC , Ling GS, Wu J, Poon JF, Kan EM, Tan MH, Wu YJ, Li P...Moochhala S, Yap E, Lee LK, Teo AL, Yeh IB, Ser- gio DM, Chua F, Kumar SD, Ling EA: Effect of blast exposure on the brain structure and cognition in the...12689448] 32. Henderson D, Bielefeld EC, Harris KC , Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27(1):1–19. [PMID

  18. A Research on Strategic Ambidexterity from the Perspective of Upper Echelons Theory%基于高阶理论视角的战略双元研究

    Institute of Scientific and Technical Information of China (English)

    王艺霖; 王益民

    2015-01-01

    文章以高阶理论和资源依赖理论为基础,探讨了制度转型期中国企业高管团队行为整合、政治联系、中庸思维与战略双元之间的关系。通过问卷调查的方式进行实证研究,研究结果表明,高管团队行为整合、高管团队政治联系对战略双元有正向影响。高管团队中庸思维弱化了高管团队行为整合与战略双元之间的关系。%Based on upper echelons theory and resource dependence theory,the paper examines the relationship between top management team behavioral integration,political connection,Zhong-yong thinking and strategic ambidexterity in Chinese enterprises during the process of institutional transition. The paper also makes an empirical study through questionnaire sur⁃vey. The findings show that both top management team behavioral integration and top management team political connection have positive relationships with strategic ambidexterity. Furthermore, top management team Zhong-yong thinking weakens the relationship between top management team behavioral integration and strategic ambidexterity.

  19. A Multiscale Enrichment Procedure for Nonlinear Monotone Operators

    KAUST Repository

    Efendiev, Yalchin R.; Galvis, J.; Presho, M.; Zhou, J.

    2014-01-01

    . Galvis, R. Lazarov, S. Margenov and J. Ren, Robust two-level domain decomposition preconditioners for high-contrast anisotropic flows in multiscale media. Submitted.; Y. Efendiev, J. Galvis and X. Wu, J. Comput. Phys. 230 (2011) 937–955; J. Galvis and Y

  20. Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappa B in human tongue carcinoma - BLCAP overexpression induces S phase arrest and apoptosis

    NARCIS (Netherlands)

    Yao, Jun; Duan, Li; Fan, Mingwen; Yuan, Jianhuan; Wu, Xinxing

    Bladder cancer-associated protein gene (BLCAP) is a novel candidate tumor suppressor gene identified from the human bladder carcinoma. Our previous studies have shown that BLCAP overexpression could inhibit cell growth by inducing apoptosis in HeLa cells [Zuo Z, Zhao M, Liu J, Gao G, Wu X: Tumor

  1. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Chen Bin1 Zeng Zhirong1 Wu Xiaoqin1 Chen Minhu1 Li Mei1 Gao Xiang1 Chen Baili1 Hu Pinjin1. Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of China ...

  2. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 125; Issue 8. Formation and evolution of yardangs activated by Late Pleistocene tectonic movement in Dunhuang, Gansu Province of China. Yanjie Wang Fadong Wu Xujiao Zhang Peng Zeng Pengfei Ma Yuping Song Hao Chu. Volume 125 Issue 8 December ...

  3. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 95; Issue 1. Distribution and linkage disequilibrium analysis of polymorphisms of GH1 gene in different populations of pigs associated with body size. Yunyun Cheng Songcai Liu Dan Su Chao Lu Xin Zhang Qingyan Wu Siming Li Haoyu Fu Hao Yu Linlin Hao. Research Article ...

  4. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Jiandong Wu1 Xiaolei Jin1 Yang Zhao1 Qing Dong1 Haiyang Jiang1 Qing Ma1. Key Laboratory of Crop Biology of Anhui Province, School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China ...

  5. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Home; Journals; Journal of Astrophysics and Astronomy; Volume 35; Issue 3. Correlations between Optical Variability and Physical Parameters of Quasars. Wenwen Zuo Xue-Bing Wu Yi-Qing Liu Cheng-Liang Jiao. Part V: Black Holes (or Binary Black Holes) in Blazars Volume 35 Issue 3 September 2014 ...

  6. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Ping Chen1 2 Qing-Sheng Wu1 Ya-Ping Ding3 Pin-Shi Yuan1. Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China; Department of Chemistry, Chizhou College, Chizhou, Anhui 247000, P.R. China; Department of Chemistry, Shanghai University, Shanghai 200436, P.R. China ...

  7. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Yu-Song Guo Zhong-Duo Wang Cheng-Zhong Yan Yu-Lan Zhang Jin-Nan Zheng Yuan-Min Xu Tao Du Chu-Wu Liu · More Details Fulltext PDF ... Aifu Yang Dapeng Sun Shikai Liu Ying Dong Zhong Chen Zunchun Zhou · More Details Fulltext ...

  8. Tropical Journal of Pharmaceutical Research - Vol 15, No 3 (2016)

    African Journals Online (AJOL)

    Wan Wu, Wei Chen, Qiong Jin, 447-451 ... Chung-Shih Chen, Mei-Lin Wang, Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chien-Fu Huang, ... Yan-Qiong Li, Rui Hu, Li-Hui Zhong, Qian Sun, You-Ping Yan, 527-533.

  9. Spacing conservation practice: Place-making, social learning, and adaptive governance in natural resource management [Chapter 15

    Science.gov (United States)

    Daniel R. Williams

    2018-01-01

    Nature conservation constitutes an important realm of professional practice with strong connections to the discourses on nature and sustainability. In recent decades much of that discourse has taken an explicitly spatial turn, observable across numerous domains of ecological, social, and political thought (Williams et al., 2013; Wu, 2006). The aim of this chapter is to...

  10. Detailed balance principle and finite-difference stochastic equation in a field theory

    International Nuclear Information System (INIS)

    Kozhamkulov, T.A.

    1986-01-01

    A finite-difference equation, which is a generalization of the Langevin equation in field theory, has been obtained basing upon the principle of detailed balance for the Markov chain. Advantages of the present approach as compared with the conventional Parisi-Wu method are shown for examples of an exactly solvable problem of zero-dimensional quantum theory and a simple numerical simulation

  11. An Integrated Ignition and Combustion System for Liquid Propellant Micro Propulsion

    Science.gov (United States)

    2008-06-26

    using a microfin electrode array. They demonstrated successful gasification and ignition of the liquid propellant using this concept. The concept has...Transition to Detonation of Stoichiometric Ethylene/Oxygen in Microscale Tubes (with M-H. Wu, M.P. Burke, and S.F. Son) Proceedings of the

  12. Chinese physicists and the CERN group invited to visit China in September 1975

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    At the National Peoples Congress Palace in Peking, Wu Lein-Fu (centre) between W. Weisskopf and W. Jentschke. Second from left Mrs Weisskopf. At the back (centre) L. Van Hove, Mrs Van Hove, G. Charpak. See CERN Courier of October 1975.

  13. The Toxicity of Nitroguanidine and Photolyzed Nitroguandine to Freshwater Aquatic Organisms

    Science.gov (United States)

    1985-03-01

    presently stored in lagoons and holding ponds; release of Wu could result from leakage, overflows, or leaching from the storage facilities. 2...111-112. *16. American Society for Testing and Materials. 1980. Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates

  14. Antibiotic stewardship – it starts with you!

    African Journals Online (AJOL)

    implemented along with infection control measures, especially hand hygiene interventions ... thrown its support behind a National Strategic Framework tackling ... This open-access article is distributed under ... Hughes JS, Hurford A, Finley RL, Patrick DM, Wu J, Morris AM. How to ... Dedicated to quality care for the critically ill.

  15. Reference Correction to: Making Air Pollution Visible: A Tool for Promoting Environmental Health Literacy.

    Science.gov (United States)

    Galkina Cleary, Ekaterina; Patton, Allison P; Wu, Hsin-Ching; Xie, Alan; Stubblefield, Joseph; Mass, William; Grinstein, Georges; Koch-Weser, Susan; Brugge, Doug; Wong, Carolyn

    2017-12-20

    [This corrects the article DOI: 10.2196/publichealth.7492.]. ©Ekaterina Galkina Cleary, Allison P Patton, Hsin-Ching Wu, Alan Xie, Joseph Stubblefield, William Mass, Georges Grinstein, Susan Koch-Weser, Doug Brugge, Carolyn Wong. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 20.12.2017.

  16. Evolution of the defensin-like gene family in grass genomes

    Indian Academy of Sciences (India)

    . Jiandong Wu, Xiaolei Jing, Yang Zhao, Qing Dong, Haiyang Jiang and Qing Ma. J. Genet. 95, 53–62. Table 1. Information about DEFL genes in B. distachyon, O. sativa, S. bicolor and Z. mays. Species. Gene name. Gene identifer. ORF (aa).

  17. Who Defends the Stem Cell's Citadel?

    Science.gov (United States)

    Strick-Marchand, Hélène; Durantel, David

    2018-03-01

    Recently in Cell, Wu et al. (2018) demonstrated that intrinsic expression of a subset of interferon stimulated genes confers resistance to viral infections in stem cells both in vitro and in vivo, while differentiated cells lose this intrinsic gatekeeper expression pattern in favor of inducible interferon responses. Copyright © 2018 Elsevier Inc. All rights reserved.

  18. Compacton solutions and multiple compacton solutions for a continuum Toda lattice model

    International Nuclear Information System (INIS)

    Fan Xinghua; Tian Lixin

    2006-01-01

    Some special solutions of the Toda lattice model with a transversal degree of freedom are obtained. With the aid of Mathematica and Wu elimination method, more explicit solitary wave solutions, including compacton solutions, multiple compacton solutions, peakon solutions, as well as periodic solutions are found in this paper

  19. Factors Influencing Vitamin A Status of Lactating Mothers in ...

    African Journals Online (AJOL)

    Factors Influencing Vitamin A Status of Lactating Mothers in Manyara and ... E.L Ndau, D. Walters, D. Wu, N. Saleh, T.C.E. Mosha, S. Horton, H.S. Laswai ... for young mothers, 84.6% for middle age mothers and 86.3% for elderly mothers.

  20. Music Mashine

    Index Scriptorium Estoniae

    2003-01-01

    Dresdeni Sümfooniaorkester esitas kompositsiooni Rammsteini loost. Wu Tang Clan kavatseb laiali minna. K. Novoselic (Nirvana) kavatseb tegeleda poliitikaga. Üritusest "Manka Boutique". Black Sabbath ei pääsenud Kuulsuste Saali. Evanescence tühistas kontserdid Ameerika Ühendriikides

  1. Kolga koolis andsid tunde hiinlased / Ülle Tamm

    Index Scriptorium Estoniae

    Tamm, Ülle

    2016-01-01

    Tallinna Ülikooli Konfutsiuse Instituudi neli õppejõudu - Zhuoya Wu, Xiuping Huang, Sandra Sainio ja Kristiina Kraft viisid Kolga koolis toimunud Hiina päeval läbi töötubasid ja loenguid hiina keelest ja kultuurist

  2. Modern Foreign Languages: A Refereed International Journal of Linguistics and Applied Linguistics, 2000.

    Science.gov (United States)

    Ying, Du, Ed; Zidong, Huang, Ed.

    2000-01-01

    These four issues include articles on: "The Syntax of DeP in Chinese" (Wu Gang); "Relevance in Cognition, Communication and Logic" (Xiong Xueliang); "A Survey of Chinese Learners' Use of English Verbs in Grammatical and Lexical Patterns" (Pu Jianzhong); "A Systemic Study of Projection in English Clause…

  3. Het geheim van Alibaba

    NARCIS (Netherlands)

    den Butter, F.A.G.; Wu, X.

    2016-01-01

    Alibaba is in korte tijd uitgegroeid tot het grootste internet handelsplatform in de wereld. Volgens de Amsterdamse hoogleraar Frank den Butter en de Chinese studente Xiaoyi Wu weet Alibaba uitstekend in te spelen op de Chinese cultuur en instituties bij het omlaag brengen van de kosten van

  4. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 129; Issue 8. Three coordination compounds based on benzene tetracarboxylate ligand: syntheses, structures, thermal behaviors and luminescence properties. YUNLONG WU CHANGKUN XIA JUN QIAN JIMIN XIE. REGULAR ARTICLE Volume 129 Issue 8 August ...

  5. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Wang Juan1 Li Yajiang1 Wu Huiqiang1 Ren Jiangwei1. Key Lab of Liquid Structure and Heredity of Materials, Ministry of Education, School of Materials Science and Engineering, Shandong University, Jinan 250061, P.R. China ...

  6. Holomorphic representation of constant mean curvature surfaces in Minkowski space: Consequences of non-compactness in loop group methods

    DEFF Research Database (Denmark)

    Brander, David; Rossman, Wayne; Schmitt, Nicholas

    2010-01-01

    We give an infinite dimensional generalized Weierstrass representation for spacelike constant mean curvature (CMC) surfaces in Minkowski 3-space $\\R^{2,1}$. The formulation is analogous to that given by Dorfmeister, Pedit and Wu for CMC surfaces in Euclidean space, replacing the group $SU_2$ with...

  7. The loss of genetic diversity in the Chinese paddlefish (Psephurus ...

    Indian Academy of Sciences (India)

    Unknown

    The loss of genetic diversity in the Chinese paddlefish. (Psephurus gladius Martens) as revealed by DNA fingerprinting. XUE-CHANG WU*. College of Life Sciences and the Key Laboratory of Conservation Genetics and Reproductive Biology for Endangered. Wild Animals of the Ministry of Education, Zhejiang University, ...

  8. Modellering van begrazing in SUMO : verbetering van de vegetatiemodellering in de Natuurplanner

    NARCIS (Netherlands)

    Wamelink, G.W.W.; Wegman, R.M.A.; Slim, P.A.; Dirksen, J.; Mol-Dijkstra, J.P.; Dobben, van H.F.

    2001-01-01

    In samenwerking met het RIVM en WU wordt het vegetatievoorspellingsmodel SUMO ontwikkeld. Het model vormt een integraal onderdeel met SMART en wordt onder andere gebruikt in de natuurplanner van het RIVM. Om de modellering van de effecten van begrazing op de vegetatieontwikkeling en successie

  9. Schrodinger's cat versus Darwin

    OpenAIRE

    Silagadze, Z. K.

    2009-01-01

    Sun Wu-k'ung, an immortal Monkey-King of Chaos learns modern physics from the Patriarch Bodhi and questions the Darwinian evolution. He finds that the modern physics indicates towards the intelligent design as a vastly more probably origin of humans than the random evolution by mutations and natural selection.

  10. Short Report Assessing the feasibility of mobile phones for follow ...

    African Journals Online (AJOL)

    largely paper-based. As part of a feasibility study ... Committee in Malawi and by the University of Washington,. USA. Victoria Hardy1, Jenny Hsieh2, Baxter Chirambo3, Tsung-Shu Joseph Wu2, John O'Donoghue4,. Adamson S. Muula5 ...

  11. A study of the frequency of methylation of gene promoter regions in ...

    Indian Academy of Sciences (India)

    2013-04-02

    Apr 2, 2013 ... colorectal cancer in the Taiwanese population. CHANG-CHIEH WU1 ... hypermethylation of promoter-region CpG islands is an important ... mismatch repair gene MLH1 plays an important role in dele- ..... Asia Pac. J. Clin.

  12. Role of Inflammation in MPTP-Induced Dopaminergic Degeneration

    Science.gov (United States)

    2005-12-01

    outside midbrain, Mol. Brain Res. 18 (1993) 181- 186. [12] F.C. Clheng, D.R. Ni, M.C. Wu, J.S. Kuo, L.G. Chia , Glial cell line- derived neurotrophic...neurodegenerative for oxidative stress in the pathogenesis of Parkinson’s disease? Life diseases: pathophysiology and therapeutic interventions, Alzheimer

  13. Approaching Resistance to Targeted Inhibition of PI3K in Breast Cancer

    Science.gov (United States)

    2011-10-01

    R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastru W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P...LC (1998) Phosphoinositide kinases. Annu Rev Biochem 67:481–507 Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E

  14. Examining the Complexities of School-Museum Partnerships

    Science.gov (United States)

    Gupta, Preeti; Adams, Jennifer; Kisiel, James; Dewitt, Jennifer

    2010-01-01

    We examine the research conducted by Kang, Anderson and Wu by discussing it in a larger context of science museum-school partnerships. We review how the disconnect that exists between stakeholders, the historical and cultural contexts in which formal and informal institutions are situated, and ideas of globalization, mediate the success for…

  15. dimensional nonlinear Schrödinger equation with spatially

    Indian Academy of Sciences (India)

    Hong-Yu Wu

    2017-08-16

    Aug 16, 2017 ... HONG-YU WU. ∗ and LI-HONG JIANG ... Our present work provides a detailed answer to these questions. ... with the self-consistency condition |Y(θ,ϕ)|2 = 1. Equation (4) .... [4] L Q Kong and C Q Dai, Nonlinear Dyn. 81, 1553 ...

  16. The Effects of Observation Errors on the Attack Vulnerability of Complex Networks

    Science.gov (United States)

    2012-11-01

    Watts & Strogatz , 1998), or scale-free communities (Lancichinetti & Fortunato, 2009)), a size (25, 50 or 100 nodes) and a density (0.01, 0.02, 0.05...D. J. & Strogatz , S. H., 1998. Collective dynamics of ’small-world’ networks. Nature, 4 June, Volume 393, pp. 440-442. 13. Wu, J., Deng, H.-Z

  17. 78 FR 67363 - Findings of Research Misconduct

    Science.gov (United States)

    2013-11-12

    ... University--Canada (formerly University of Western Ontario): Based on the report of an investigation conducted by Western University--Canada (WU) and ORI's subsequent oversight analysis, ORI found that Dr. Hao...-supported research, Respondent shall ensure that a plan for supervision of his duties is submitted to ORI...

  18. Lentinan treatment of Plasmodium yoelii-infected mice induces ...

    African Journals Online (AJOL)

    Yomi

    2012-01-31

    Jan 31, 2012 ... infected mice results in down-regulation of the Th1-type immune response, leading to death (Wu et al., 2007;. Amante et al., 2007). Thus, these cells help to promote the pathogenesis of malaria. Several treatments are commonly used to combat malaria; most often is quinine administration (Sahu et al.,.

  19. An Application of Supervised Learning Methods to Search for Variable Stars in a Selected Field of the VVV Survey

    Science.gov (United States)

    Rodríguez-Feliciano, B.; García-Varela, A.; Pérez-Ortiz, M. F.; Sabogal, B. E.; Minniti, D.

    2017-07-01

    We characterize properties of time series of variable stars in the B278 field of the VVV survey, using robust statistics. Using random forest and support vector machines classifiers we propose 47 candidates to RR Lyraae, and 12 candidates to WU Ursae Majoris eclipsing binaries.

  20. Effects of palm oil mill effluent (POME) anaerobic sludge from 500 m ...

    African Journals Online (AJOL)

    USER

    2010-04-19

    Apr 19, 2010 ... in the country (Lau et al., 2008). Thus, the ... within 80 days with final C/N ratio of 12.5. .... C/N ratio of pressed shredded EFB was 54.4 with carbon ..... Wong JWC, Mak KF, Chan NW, Lam A, Fang M, Zhou LX, Wu QT, Liao.