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Sample records for yong man ro

  1. Zhong-Yong as Dynamic Balancing Between Yin-Yang Opposites

    DEFF Research Database (Denmark)

    Li, Xin

    2018-01-01

    of Zhong-Yong balancing being incorrect and incomplete, the author proposes an alternative perspective on Zhong-Yong as dynamic balancing between Yin-Yang opposites. Design/methodology/approach: The author first explain why Peter P. Li’s “asymmetry” and “superiority” arguments are flawed by referring...... to the original text of the classical book of Zhong-Yong (中庸) and a comparison between Zhong-Yong and Aristotle’s doctrine of the mean. The author then propose an alternative approach to Zhong-Yong balancing that is embedded in the original text Zhong-Yong but somehow has been neglected by many Chinese scholars...

  2. Individual Differences in Zhong-Yong tendency and Processing Capacity

    Directory of Open Access Journals (Sweden)

    Ting-Yun eChang

    2014-11-01

    Full Text Available The present study investigated how an individual’s Zhong-Yong tendency is related to his/her perceptual processing capacity. In two experiments, participants completed a Zhong-Yong Thinking Style Scale and performed a redundant-target detection task. Processing capacity was assessed with a nonparametric approach (systems factorial technology, SFT and a parametric (linear ballistic accumulator model, LBA approach. Results converged to suggest a positive correlation between Zhong-Yong tendency and processing capacity. High middle-way thinkers had larger processing capacity in multiple-signal processing compared with low middle-way thinkers, indicating that they processed information more efficiently and in an integrated fashion. Zhong-Yong tendency positively correlates with the processing capacity. These findings suggest that the individual differences in processing capacity can account for the reasons why high middle-way thinkers tend to adopt a global and flexible processing strategy to deal with the external world. Furthermore, the influence of culturally dictated thinking style on cognition can be revealed in a perception task.

  3. Valores, Creencias Y Objectivos: Base del programa de la Escuela Experimental P.K. Yonge. (Values, Beliefs and Objectives: The Basis of Experimental Schools P.K. Yonge's Program.)

    Science.gov (United States)

    Florida Univ., Gainesville. Coll. of Education.

    The values, beliefs, and objectives that form the core of the program at the Experimental School P.K. Yonge in the University of Florida are presented in this paper which is written in Spanish. This experimental school serves approximately 900 students from grades one through twelve. The function of the school is to conduct research to solve…

  4. Zhong-Yong as Dynamic Balancing Between Yin-Yang Opposites

    DEFF Research Database (Denmark)

    Li, Xin

    2017-01-01

    Purpose The purpose of this paper is to comment on Peter Ping Li’s understanding of Zhong-Yong balancing, presented in his article titled “Global implications of the indigenous epistemological system from the East: How to apply Yin-Yang balancing to paradox management.” Seeing his understanding....... Originality/value This commentary contributes to the “West meets East” discourse by debunking Peter P. Li’s assertion that Yin-Yang balancing is superior as a solution to paradox management and his prescription that balancing between Yin-Yang opposites must be asymmetric. It also contributes to the Chinese...

  5. Kim Wŏn-haeng’s Intellectual Influences on Hong Tae-yong: The Case of Relations between

    Directory of Open Access Journals (Sweden)

    Login Lok-yin Law

    2015-08-01

    Full Text Available In the 18th century Chosŏn (1392-1910, some scholars, such as Hong Tae-yong (1731-1783 advocated that Chosŏn should learn the advantages of the Qing (1644-1912 society to reform the social structure and government of Chosŏn. The school of these advocates has been known as Pukhak by historians. The intellectual factors of the school of Pukhak’s formation and development have been overlooked by the academia of Chosŏn intellectual history. In fact, Pukhak was closely related to the idea of the school of Nakhak which believed that nature of things was equivalent to humans. Kim Wŏn-haeng, was one of the supporters of Nakhak and Hong Tae-yong was one of the students of Kim. Hong’s thought and writing exposed that his thought was profoundly influenced by Kim Wŏn-haeng. Hong was deemed to be the first prominent scholar of the Pukhak School during the 18th century Chosŏn. Hong and other scholars of Pukhak advocated learning the new knowledge from Qing China even though it was a barbarian society. Therefore, this paper will investigate the intellectual relationships between Hong Tae-yong and Kim Wŏn-haeng to reveal how intellectuals of Nakhak shaped the formation of Pukhak School and exposed the idea of learning from Qing China.

  6. Deposition of reactive nitrogen during the Rocky Mountain Airborne Nitrogen and Sulfur (RoMANS) study

    International Nuclear Information System (INIS)

    Beem, Katherine B.; Raja, Suresh; Schwandner, Florian M.; Taylor, Courtney; Lee, Taehyoung; Sullivan, Amy P.; Carrico, Christian M.; McMeeking, Gavin R.; Day, Derek; Levin, Ezra; Hand, Jenny; Kreidenweis, Sonia M.; Schichtel, Bret; Malm, William C.; Collett, Jeffrey L.

    2010-01-01

    Increases in reactive nitrogen deposition are a growing concern in the U.S. Rocky Mountain west. The Rocky Mountain Airborne Nitrogen and Sulfur (RoMANS) study was designed to improve understanding of the species and pathways that contribute to nitrogen deposition in Rocky Mountain National Park (RMNP). During two 5-week field campaigns in spring and summer of 2006, the largest contributor to reactive nitrogen deposition in RMNP was found to be wet deposition of ammonium (34% spring and summer), followed by wet deposition of nitrate (24% spring, 28% summer). The third and fourth most important reactive nitrogen deposition pathways were found to be wet deposition of organic nitrogen (17%, 12%) and dry deposition of ammonia (14%, 16%), neither of which is routinely measured by air quality/deposition networks operating in the region. Total reactive nitrogen deposition during the spring campaign was determined to be 0.45 kg ha -1 and more than doubled to 0.95 kg ha -1 during the summer campaign. - The reactive nitrogen deposition budget for Rocky Mountain National Park.

  7. Dalla pizza alla cura dell’uomo, le abilità di RoDyMan

    Directory of Open Access Journals (Sweden)

    Nunzia Bonifati

    2014-12-01

    Full Text Available RoDyMan, acronym for Robotic Dynamic Manipulation, is a research project funded by the European Research Council to the CREATE Consortium and carried out at PRISMA Lab in the Department of Electrical Engineering and Information Technology of the University of Naples Federico II. The goal is the development of a service robot able to manipulate elastic and soft objects, which change continuously density and shape. These robots will be used not only in manufacturing but also as an aid to elderly or disabled people, for medical and surgical use, and in other manual activities. Preparing a pizza involves an extraordinary level of manual dexterity: for this reason a pizzaiolo robot has been conceived. It is also a tribute to Naples, at the forefront of technology, robotics and automation, but especially of culture and gastronomy, of which pizza is a symbol and tradition. Creating a robot able to manipulate objects like humans is one of the most sought and difficult challenges of robotics. It means to replicate skills that are the result of human biological and cultural evolution. This goal is arduous, mainly for two issues. First, we do not have a total knowledge of human nature, but this is the condition to be able to replicate the human functions in a machine. Second, there are many technical limits to implement a bio-inspired robot, not the least those making it user-friendly and aesthetically appreciated.

  8. Evaluation of RO modules for the SSP ETC/LSS.

    Science.gov (United States)

    Jasionowski, W. J.; Bambenek, R. A.

    1973-01-01

    During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

  9. Art as a Political Act: Expression of Cultural Identity, Self-Identity, and Gender by Suk Nam Yun and Yong Soon Min

    Science.gov (United States)

    Caruso, Hwa Young Choi

    2005-01-01

    This cross-cultural study explored the lives of two contemporary Korean/Korean American women artists--Suk Nam Yun and Yong Soon Min--who live in Seoul, South Korea, and Los Angeles, California. The author's research focused on the artists' identity formation, artistic expression, professional achievements, and the role of art as a political act.…

  10. Man-influenced vegetation of North Korea

    Czech Academy of Sciences Publication Activity Database

    Kolbek, Jiří; Jarolímek, I.

    2008-01-01

    Roč. 40, č. 1 (2008), s. 381-404 ISSN 0253-116X R&D Projects: GA ČR(CZ) GA206/05/0119 Institutional research plan: CEZ:AV0Z60050516 Keywords : vegetation classification * weed communities * man-depending vegetation Subject RIV: EF - Botanics

  11. Capacity Analysis of Ro-Ro Terminals by Using Simulation Modeling Method

    Directory of Open Access Journals (Sweden)

    Emin Deniz Özkan

    2016-09-01

    Full Text Available In Ro-Ro terminals, terminal capacity is more needed than other types of marine terminals since Ro-Ro cargoes cannot be stacked. In this sense, the variables affecting capacity of a Ro-Ro terminal can be listed as follows; number of vehicles arrived to a terminal, distance between terminals, ship capacity, terminal gates, customs control units, terminal traffic and local traffic, security check, bunkering services etc. In this study, a model generated intended for making capacity analysis in Ro-Ro terminals by using simulation modeling method. Effect of three variables to terminal capacity was investigated while generating the scenarios; ‘number of trucks arriving to terminals’, ‘distance between terminals’ and ‘Ro-Ro ship capacity’. The results show that the variable which affect terminal capacity mostly is ‘number of trucks arriving to terminals’. As a consequence of this situation, it is thought that a Ro-Ro terminal operator must prioritize the demand factor and make an effective demand forecasting in determination of the terminal area.

  12. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007).

    OpenAIRE

    Alzo David-West

    2013-01-01

    This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses...

  13. Application Side Casing on Open Deck RoRo to Improve Ship Stability

    Science.gov (United States)

    Hasanudin; K. A. P Utama, I.; Chen, Jeng-Horng

    2018-03-01

    RoRo is a vessel that can transport passengers, cargo, container and cars. Open Car Deck is favourite RoRo Vessel in developing countries due to its small GT, small tax and spacious car deck, but it has poor survival of stability. Many accident involve Open Car Deck RoRo which cause fatalities and victim. In order to ensure the safety of the ship, IMO had applied intact stability criteria IS Code 2008 which adapted from Rahola’s Research, but since 2008 IMO improved criteria become probabilistic damage stability SOLAS 2009. The RoRo type Open Car Deck has wide Breadth (B), small Draft (D) and small freeboard. It has difficulties to satisfy the ship’s stability criteria. Side Casings which has been applied in some RoRo have be known reduce freeboard or improve ship’s safety. In this paper investigated the effect side casings to survival of intact dan damage ship’s stability. Calculation has been conducted for four ships without, existing and full side casings. The investigation results shows that defect stability of Open Deck RoRo can be reduce with fitting side casing.

  14. Probabilistic Analysis of Collision Damages with Application to ro-Ro Passenger Vessels

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup; Hansen, Peter Friis; Nielsen, Lars Peter

    1997-01-01

    To quantify the risks involved in Ro-ro passenger vessel traffic, rational criteria for prediction and evaluation of collision accidents have to be developed. This implies that probabilities as well as the inherent consequences have to be analyzed and assessed.The present report outlines a method...... for evaluation of the probability of a Ro-Ro passenger vessel on a given route being struck by another ship. Given a collision has taken place the spatial distribution of the collision damages is calculated. Results are presented in terms of probability distributions, for indentation depth, length and height...... of the holes and for the vertical location. The main benefit of the formulated procedure is that it allows comparisons of various navigation routes by assessing the relative frequencies of collisions. The derived procedure is applied to two typical Ro-Ro passenger vessel routes....

  15. Environmental Performance Evaluation of Ro-Ro Passenger Ferry Transportation

    DEFF Research Database (Denmark)

    Kristensen, Hans Otto Holmegaard; Hagemeister, Constantin

    2012-01-01

    /or emissions per transport unit, is related to the same unit for the different transport forms. For Ro-Ro passenger ferries it can be difficult to find a suitable common transport unit, as they often transport a mix of cargo, such as passengers, passenger cars, trucks, lorries, busses and other rolling...

  16. The Assessment of the Ultimate Hull Girder Strength of RO-RO Ship after Damages

    Science.gov (United States)

    Zubair Muis Alie, Muhammad; Sitepu, Ganding; Izaak Latumahin, Samuel

    2018-03-01

    Many accidents of Ro-Ro ships happen in Indonesia such as collision and grounding. When the collision or grounding takes place on the Ro-Ro ship, the ultimate strength of hull structure after damage becomes decrease. Car and passenger decks are critical location since collision and/or grounding occur. In the present study, the assessment of the ultimate hull girder strength is conducted. The cross section of Ro-Ro ship is taken to be analyzed. The collision and grounding damages are assumed to be palced on the side and bottom area, respectively. The damages are created by removing the element from the side shell and bottom part. Finally, the result obtained is compared with one another.

  17. ps-ro Fuzzy Open(Closed Functions and ps-ro Fuzzy Semi-Homeomorphism

    Directory of Open Access Journals (Sweden)

    Pankaj Chettri

    2015-11-01

    Full Text Available The aim of this paper is to introduce and characterize some new class of functions in a fuzzy topological space termed as ps-ro fuzzy open(closed functions, ps-ro fuzzy pre semiopen functions and ps-ro fuzzy semi-homeomorphism. The interrelation among these concepts and also their relations with the parallel existing concepts are established. It is also shown with the help of examples that these newly introduced concepts are independent of the well known existing allied concepts.

  18. Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.

    Science.gov (United States)

    Honer, Michael; Gobbi, Luca; Knust, Henner; Kuwabara, Hiroto; Muri, Dieter; Koerner, Matthias; Valentine, Heather; Dannals, Robert F; Wong, Dean F; Borroni, Edilio

    2018-04-01

    Tau aggregates and amyloid-β (Aβ) plaques are key histopathologic features in Alzheimer disease (AD) and are considered targets for therapeutic intervention as well as biomarkers for diagnostic in vivo imaging agents. This article describes the preclinical in vitro and in vivo characterization of 3 novel compounds-RO6958948, RO6931643, and RO6924963-that bind specifically to tau aggregates and have the potential to become PET tracers for future human use. Methods: RO6958948, RO6931643, and RO6924963 were identified as high-affinity competitors at the 3 H-T808 binding site on native tau aggregates in human late-stage AD brain tissue. Binding of tritiated compounds to brain tissue sections of AD patients and healthy controls was analyzed by macro- and microautoradiography and by costaining of tau aggregates and Aβ plaques on the same tissue section using specific antibodies. All 3 tracer candidates were radiolabeled with a PET nuclide and tested in vivo in tau-naïve baboons to assess brain uptake, distribution, clearance, and metabolism. Results: 3 H-RO6958948, 3 H-RO6931643, and 3 H-RO6924963 bound with high affinity and specificity to tau aggregates, clearly lacking affinity for concomitant Aβ plaques in human AD Braak V tissue sections. The specificity of all 3 radioligands for tau aggregates was supported, first, by binding patterns in AD sections comparable to the tau-specific radioligand 3 H-T808; second, by very low nonspecific binding in brain tissue devoid of tau pathology, excluding significant radioligand binding to any other central nervous system target; and third, by macroscopic and microscopic colocalization and quantitative correlation of radioligand binding and tau antibody staining on the same tissue section. RO6958948, RO6931643, and RO6924963 were successfully radiolabeled with a PET nuclide at high specific activity, radiochemical purity, and yield. After intravenous administration of 18 F-RO6958948, 11 C-RO6931643, and 11 C-RO6924963 to

  19. Decision Making Model for Ro-Ro Short Sea Shipping Operations in Archipelagic Southeast Asia

    Directory of Open Access Journals (Sweden)

    Aminuddin Md Arof

    2018-03-01

    Full Text Available This study aims to develop a decision-making model for determining the potential of interstate Ro-Ro Short Sea Shipping (SSS operations in Archipelagic Southeast Asia (ASEA. It is expected to assist SSS authorities, private investors and financial institutions focus their limited resources on several key factors that could ensure the success of their undertakings. This study will begin with identifying the relevant factors that have contributed towards successful SSS operations through a process of literature review. Subsequently, a Delphi survey was conducted with sub-regional experts to identify any new determinants and assess their opinions on the relative importance of all the determinants involved. Finally the weightages of the determinants were ascertained through the Analytic Hierarchy Process (AHP. Twenty expert respondents from Brunei Darussalam. Indonesia, Malaysia and the Philippines were involved in the Delphi survey while 18 expert respondents continue to participate in the AHP survey. This study concludes with the development of a decision-making model that was tested on three interstate Ro-Ro SSS routes within the ASEA sub-region. Keywords: Archipelagic Southeast Asia, Analytic Hierarchy Process (AHP, ASEAN, Delphi, Ro-Ro, Short Sea Shipping (SSS

  20. Crisis of Modern Man and Perspective of Eternity in Light of T. G. Masaryk's Thinking

    Czech Academy of Sciences Publication Activity Database

    Svoboda, Jan

    2014-01-01

    Roč. 11, č. 2 (2014), s. 130-135 ISSN 1214-4967 Institutional support: RVO:67985955 Keywords : T.G. Masaryk's thinking * crisis of modern man * perspective of eternity * new religion * human rights Subject RIV: AA - Philosophy ; Religion

  1. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007.

    Directory of Open Access Journals (Sweden)

    Alzo David-West

    2013-11-01

    Full Text Available This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses the structural relations of the narrative, its discourse on desire, its apparent intentions, and its contravening elements, revealing an incidental unstable narrative that is symbolically protesting of the moral of the story to affectionately embrace the political authority of the North Korean party-army regime in the military-first (songun era.

  2. Argument ÜRO vastu / Joshua Muravchik

    Index Scriptorium Estoniae

    Muravchik, Joshua

    2004-01-01

    ÜRO rollist Somaalias, Rwandas ja Bosnias, Iisraeli eristaatusest. ÜRO silmakirjalikkusest inimõiguste alal, terrorismi legaliseerimisest, Kofi Annani juhtimisstiilist. Maailmas on pärast 1945. aastat valitsenud suhteline rahu mitte tänu ÜRO-le, vaid peamiselt USA tegevusele, leiab autor

  3. Elements of Risk Analysis for Collision and Grounding of a RoRo Passenger Ferry

    DEFF Research Database (Denmark)

    Otto, S.; Pedersen, Preben Terndrup; Samuelidis, M.

    2002-01-01

    Newly developed software was applied to study the effects of damages due to collision and grounding. The annual risk of collision and grounding was computed for an example RoRo passenger ferry. Collision frequency was evaluated for a specified route taking into account traffic data. Grounding...

  4. SU-E-T-218: The IHE-RO Helper Tool: Demonstrating the Connectivity Issues Solved by IHE-RO.

    Science.gov (United States)

    Kapoor, Rishabh; Yeung, Daniel; Kumar, Sabari Ajay; Alex, Daley; Kapur, Priyanka; Palta, Jatinder

    2012-06-01

    To develop a Web-based application (IHE-RO Helper) to allow comprehensive review of the interconnectivity and interoperability of various radiotherapy devices established through testing sanctioned by the Integrating Healthcare Enterprise-Radiation Oncology (IHE-RO). IHE-RO is an initiative sponsored by ASTRO to improve the way computer based systems in radiation oncology share information using well-defined data exchange standards (DICOM / HL7). At the IHE-RO Connectathon events over the last 4 years, 11 vendors with 14 different products have successfully tested and identified solutions to connectivity problems in treatment planning, simulation and delivery. Because the test results are highly technical, the interconnectivity issues amongst the RT devices may get overlooked by the end users. The IHE-RO helper tool is designed to operate in simple clinical terms with queries and presentations organized based on treatment techniques and clinical features that are familiar to the practitioners. For example, if you are planning to purchase a treatment planning system capable of generating plans (e.g. Stereotactic treatments) and are concerned whether the TPS can successfully transfer such data to your treatment management system (TMS) and subsequently to your treatment delivery system (TDS), the IHE-RO Helper can identify the connectivity requirements and list vendors that have successfully passed an IHE-RO Connectathon and validated their solution to the specific requirements. The IHE-RO helper tool provides a graphical and textual user interface to effectively demonstrate the solved interconnectivity problems between TPS, TMS and TDS. A report is also provided that explains the interconnectivity problems and its solutions. The IHE-RO helper is an effective tool to clearly identify vendor products that are IHE-RO compliant, thereby encourages vendor participation in testing and validation. Such a tool will be invaluable in procurement of new equipment to ensure a

  5. Premier numéro bilingue

    Directory of Open Access Journals (Sweden)

    Esther Cloutier

    2008-05-01

    Full Text Available Nous sommes heureux de vous présenter ce nouveau numéro bilingue de la revue PISTES. Nous espérons ainsi faire connaître les travaux francophones sur la santé au travail dans le monde anglo-saxon. Nous vous rappelons que la traduction de ce numéro a été rendu possible grâce à une subvention du CRSH (Conseil de la recherche en sciences humaines du Canada ainsi qu’à la contribution de certains auteurs que nous tenons à remercier. Ce numéro aborde plusieurs thèmes de recherche reliés au travail...

  6. Põhja-Korea valmistub sõjaks / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2006-01-01

    Põhja-Korea juhi Kim Yong Nami sõnul on riik nõus naasma läbirääkimistele USA-ga, kui tühistataks senised sanktsioonid Põhja-Korea vastu. ÜRO Julgeolekunõukogus alustati resolutsiooniprojekti arutamist, mis näeb ette Põhja-Koreale tuumakatsetuste eest karistusi. Lisa: Kahtlane katsetus

  7. Find selv fred og ro

    DEFF Research Database (Denmark)

    Juelskjær, Malou

    2010-01-01

    I klasseværelset er det lærerens ansvar at skabe ro. Men i de nye skolebygninger er det den enkelte elevs ansvar at finde frem til fredfyldte steder.......I klasseværelset er det lærerens ansvar at skabe ro. Men i de nye skolebygninger er det den enkelte elevs ansvar at finde frem til fredfyldte steder....

  8. IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren's syndrome reveals molecular markers of Ro/La diversification.

    Science.gov (United States)

    Wang, Jing J; Al Kindi, Mahmood A; Colella, Alex D; Dykes, Lukah; Jackson, Michael W; Chataway, Tim K; Reed, Joanne H; Gordon, Tom P

    2016-12-01

    We have used high-resolution mass spectrometry to sequence precipitating anti-Ro60 proteomes from sera of patients with primary Sjögren's syndrome and compare immunoglobulin variable-region (IgV) peptide signatures in Ro/La autoantibody subsets. Anti-Ro60 were purified by elution from native Ro60-coated ELISA plates and subjected to combined de novo amino acid sequencing and database matching. Monospecific anti-Ro60 Igs comprised dominant public and minor private sets of IgG1 kappa and lambda restricted heavy and light chains. Specific IgV amino acid substitutions stratified anti-Ro60 from anti-Ro60/La responses, providing a molecular fingerprint of Ro60/La determinant spreading and suggesting that different forms of Ro60 antigen drive these responses. Sequencing of linked anti-Ro52 proteomes from individual patients and comparison with their anti-Ro60 partners revealed sharing of a dominant IGHV3-23/IGKV3-20 paired clonotype but with divergent IgV mutational signatures. In summary, anti-Ro60 IgV peptide mapping provides insights into Ro/La autoantibody diversification and reveals serum-based molecular markers of humoral Ro60 autoimmunity. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Kandelia obovata (S., L.) Yong tolerance mechanisms to Cadmium: Subcellular distribution, chemical forms and thiol pools

    International Nuclear Information System (INIS)

    Weng Bosen; Xie Xiangyu; Weiss, Dominik J.; Liu Jingchun; Lu Haoliang; Yan Chongling

    2012-01-01

    Highlights: ► Cadmium tolerance mechanisms of Kandelia obovata was investigated systematacially. ► Thiol pool can play roles in cadmium detoxification mechanisms. ► Increasing cadmium treatment strength caused proportional increase of cadmium uptake. ► More than half of cadmium was localized in cell walls, and lowest in membranes. ► Sodium chloride and acetic acid extractable fractions were dominant. - Abstract: In order to explore the detoxification mechanisms adopted by mangrove under cadmium (Cd) stress, we investigated the subcellular distribution and chemical forms of Cd, in addition to the change of the thiol pools in Kandelia obovata (S., L.) Yong, which were cultivated in sandy culture medium treated with sequential Cd solution. We found that Cd addition caused a proportional increase of Cd in the organs of K. obovata. The investigation of subcellular distribution verified that most of the Cd was localized in the cell wall, and the lowest was in the membrane. Results showed sodium chloride and acetic acid extractable Cd fractions were dominant. The contents of non-protein thiol compounds, Glutathione and phytochelatins in K. obovata were enhanced by the increasing strength of Cd treatment. Therefore, K. obovata can be defined as Cd tolerant plant, which base on cell wall compartmentalization, as well as protein and organic acids combination.

  10. Isotope and ion selectivity in reverse osmosis desalination: geochemical tracers for man-made freshwater.

    Science.gov (United States)

    Kloppmann, Wolfram; Vengosh, Avner; Guerrot, Catherine; Millot, Romain; Pankratov, Irena

    2008-07-01

    A systematic measurement of ions and 2H/1H, 7Li/6Li, 11B/10B, 18O/ 16O, and 87Sr/86Sr isotopes in feed-waters, permeates, and brines from commercial reverse osmosis (RO) desalination plants in Israel (Ashkelon, Eilat, and Nitzana) and Cyprus (Larnaca) reveals distinctive geochemical and isotopic fingerprints of fresh water generated from desalination of seawater (SWRO) and brackish water (BWRO). The degree of isotope fractionation during the passage of water and solutes through the RO membranes depends on the medium (solvent-water vs. solutes), chemical speciation of the solutes, their charge, and their mass difference. O, H, and Sr isotopes are not fractionated during the RO process. 7Li is preferentially rejected in low pH RO, and B isotope fractionation depends on the pH conditions. Under low pH conditions, B isotopes are not significantly fractionated, whereas at high pH, RO permeates are enriched by 20 per thousand in 11B due to selective rejection of borate ion and preferential permeation of 11B-enriched boric acid through the membrane. The specific geochemical and isotopic fingerprints of SWRO provide a unique tool for tracing "man-made" fresh water as an emerging recharge component of natural water resources.

  11. RoMo

    DEFF Research Database (Denmark)

    Pedersen, Esben Warming; Hornbæk, Kasper

    2011-01-01

    In TUIs, physical/digital conflicts can occur when the digital model does not match the model implied by the spatial lay- out of tangibles. We show how tangible tabletop interfaces (TTI) can be modified to allow robot movement of tangi- bles, thereby avoiding conflicts. We present RoMo, an open...... source Java library that allow existing TTI applications to perform robot movement, and demonstrate its functionality with three applications....

  12. Secondary eclipses in the CoRoT light curves

    Directory of Open Access Journals (Sweden)

    Belmonte Juan Antonio

    2013-04-01

    Full Text Available We identify and characterize secondary eclipses in the original light curves of published CoRoT planets using uniform detection and evaluation criteria. Our analysis is based on a Bayesian statistics: the eclipse search is carried out using Bayesian model selection, and the characterization of the plausible eclipse candidates using Bayesian parameter estimation. We discover statistically significant eclipse events for two planets, CoRoT-6b and CoRoT-11b, and for one brown dwarf, CoRoT-15b. We also find marginally significant eclipse events passing our plausibility criteria for CoRoT-3b, 13b, 18b, and 21b, and confirm the previously published CoRoT-1b and CoRoT-2b eclipses.

  13. Det man hører, er man selv

    DEFF Research Database (Denmark)

    Svømmekjær, Heidi Frank

    2012-01-01

    Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013.......Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013....

  14. Patterns of plant traits in annual vegetation of man-made habitats in central Europe

    Czech Academy of Sciences Publication Activity Database

    Lososová, Z.; Chytrý, M.; Kühn, I.; Hájek, O.; Horáková, V.; Pyšek, Petr; Tichý, L.

    2006-01-01

    Roč. 8, č. 2 (2006), s. 69-81 ISSN 1433-8319 R&D Projects: GA MŠk LC06073; GA ČR(CZ) GA206/05/0020 Grant - others:ALARM(XE) GOCE-CT-2003-506675 Institutional research plan: CEZ:AV0Z60050516 Source of funding: R - rámcový projekt EK Keywords : species traits * annual vegetation * man-made habitats Subject RIV: EF - Botanics Impact factor: 2.905, year: 2006

  15. The CoRoT Exoplanet program: status & results

    Directory of Open Access Journals (Sweden)

    Moutou C.

    2011-02-01

    Full Text Available The CoRoT satellite is the first instrument hunting for planets from space. We will review the status of the CoRoT/Exoplanet program. We will then present the CoRoT exoplanetary systems and how they widen the range of properties of the close-in population and contribute to our understanding of the properties of planets.

  16. Haitilased süüdistavad kooleras ÜRO rahuvalvajaid

    Index Scriptorium Estoniae

    2010-01-01

    Paljud kohalikud elanikud on veendunud, et Haiti kooleraepideemia vallandamises on süüdi ÜRO stabilisatsioonimission MINUSTAH. Riigis on puhkenud ÜRO-vastased rahutused. ÜRO arvates on protestilaine algatatud presidendivalimisi nurjata soovivate poliitiliste liikumiste poolt

  17. Ku-pa-ro en las tablillas de Cnoso

    Directory of Open Access Journals (Sweden)

    José L. Melena

    1974-12-01

    Full Text Available This paper is intended to be a comprehensive analysis of the evidence of ku-pa-ro in the Knossos Linear B tablets. Its main purpose is to set up the importance of such aromatic plant in the Mycenaean economy at Knossos and to identify what kind of sedge was concealed under the name ku-pa-ro and what part of the plant was used and for what purposes. What it is stressed is the usage of the Cyperus rotundus L. (i. e. the ku-pa-ro in the industry of perfumes and as a food additive as well. What is inferred from the discussion on the evidence of ku-pa-ro issues a series of valuable data concerning the localization of certain place-names in the map of Crete, and concerning the explanation of ideogram *171. The high qualities of ku-pa-ro preserved in the tablets lead the author to assume that such a plant was cultivated in Crete and was one of the main aromatic plants used by the Mycenaeans in the making of perfumes.

  18. Short Review on Predicting Fouling in RO Desalination

    Directory of Open Access Journals (Sweden)

    Alejandro Ruiz-García

    2017-10-01

    Full Text Available Reverse Osmosis (RO membrane fouling is one of the main challenges that membrane manufactures, the scientific community and industry professionals have to deal with. The consequences of this inevitable phenomenon have a negative effect on the performance of the desalination system. Predicting fouling in RO systems is key to evaluating the long-term operating conditions and costs. Much research has been done on fouling indices, methods, techniques and prediction models to estimate the influence of fouling on the performance of RO systems. This paper offers a short review evaluating the state of industry knowledge in the development of fouling indices and models in membrane systems for desalination in terms of use and applicability. Despite major efforts in this field, there are gaps in terms of effective methods and models for the estimation of fouling in full-scale RO desalination plants. In existing models applied to full-scale RO desalination plants, neither the spacer geometry of membranes, nor the efficiency and frequency of chemical cleanings are considered.

  19. The implications of the new sulphur limits on the European Ro-Ro sector

    DEFF Research Database (Denmark)

    Zis, Thalis; Psaraftis, Harilaos N.

    -based alternatives. The exact repercussions of the new sulphur limits are difficult to identify in the wake of significant recent reductions of the fuel prices for both low-sulphur and heavy fuel oil. This paper presents a modal split model that estimates modal shifts vis-a-vis competing maritime and land......In an effort to reduce the environmental impacts of maritime transportation, the International Maritime Organization (IMO) designated special Sulphur Emission ControlAreas (SECAs) where ships are required to use low-sulphur fuel. In January 2015, the sulphur limit within SECAs was lowered to 0.......1%, which can only be achieved if vessels are using pricier ultra-low sulphur fuel, or invest in abatement technologies. The increased operating costs borne by Ro-Ro operators in SECAs due to the stricter limits can result in the shutting down of some routes and a redistribution of cargo flows with land...

  20. RO-PRO desalination: An integrated low-energy approach to seawater desalination

    International Nuclear Information System (INIS)

    Prante, Jeri L.; Ruskowitz, Jeffrey A.; Childress, Amy E.; Achilli, Andrea

    2014-01-01

    Highlights: • In the novel RO-PRO system, the energy produced by PRO is utilized to offset the energy consumed by the RO. • The specific energy consumption of a RO-PRO system was modeled for the first time. • A novel module-based PRO model for full-scale applications was developed. • The minimum net specific energy consumption of the modeled RO-PRO system was 1.2 kW h/m 3 at 50% RO recovery. • A sensitivity analysis showed a min RO-PRO specific energy consumption of 1.0 kW h/m 3 and a max power density of 10 W/m 2 . - Abstract: Although reverse osmosis (RO) is currently the most energy efficient desalination technology, it still requires a great deal of energy to create the high pressures necessary to desalinate seawater. An opposite process of RO, called pressure retarded osmosis (PRO), utilizes the salinity gradient between a relatively fresh impaired water source and seawater to produce pressure and hence, energy. In this paper, PRO is evaluated in conjunction with RO, in a system called RO-PRO desalination, to reduce the energy requirement of seawater RO desalination. RO-PRO specific energy consumption was modeled using RO conditions at the thermodynamic restriction and a newly developed module-based PRO model. Using a well-characterized cellulose triacetate (CTA) membrane, the minimum net specific energy consumption of the system was found to be approximately 40% lower than state-of-the-art seawater RO. A sensitivity analysis was performed to determine the effects of membrane characteristics on the specific energy production of the PRO process in the RO-PRO system. The sensitivity analysis showed that the minimum specific energy consumption using virtual membranes is approximately 1.0 kW h per m 3 of RO permeate at 50% RO recovery and that a maximum power density of approximately 10 W/m 2 could be achieved

  1. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    Energy Technology Data Exchange (ETDEWEB)

    Jauharoh, Siti Nur Aisyah [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Faculty of Medicine and Health Science, Syarif Hidayatullah State Islamic University, Jakarta 15412 (Indonesia); Saegusa, Jun; Sugimoto, Takeshi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Ardianto, Bambang [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Child Health, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55282 (Indonesia); Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Tokuno, Osamu; Nakamachi, Yuji [Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan); Kumagai, Shunichi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Kawano, Seiji, E-mail: sjkawano@med.kobe-u.ac.jp [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan)

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

  2. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    International Nuclear Information System (INIS)

    Jauharoh, Siti Nur Aisyah; Saegusa, Jun; Sugimoto, Takeshi; Ardianto, Bambang; Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo; Tokuno, Osamu; Nakamachi, Yuji; Kumagai, Shunichi; Kawano, Seiji

    2012-01-01

    Highlights: ► Ro52 low HeLa cells are resistant to apoptosis upon various stimulations. ► Ro52 is upregulated by IFN-α, etoposide, or IFN-γ and anti-Fas Ab. ► Ro52-mediated apoptosis is independent of p53. ► Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren’s syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52’s role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52 low HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H 2 O 2 - or diamide-induced oxidative stress, IFN-α, IFN-γ and anti-Fas antibody, etoposide, or γ-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

  3. [Research on Japanese monograph of comprehensive dietetic materia medica, the Pao chu bei yong wo ming ben cao (Japanese Materia Medica Prepared for Kitchen)].

    Science.gov (United States)

    Zhou, M; Ye, J

    2017-11-28

    Japanese physicians of Edo Period (1603-1867) wrote many dietetic books, by combining the knowledge system (content and compiling style) and thoughts of diet therapy from China with local condition in Japan. Among them, the Pao chu bei yong wo ming ben cao ( Japanese Materia Medica Prepared for Kitchen ), written by Mukai Genshou, a physician in the early Edo, is the earliest comprehensive work of dietetic materia medica. In this book, the choice and usage of Japanese dietetic materia medica reveals obvious Japanese local color, including the name, morphology, cultivation, collection, identification, nature and flavor, and indication etc., reflecting the sprouting idea of edible herbal plant at the beginning of Edo period and the characteristic of absorbing Chinese diet thoughts by Japanese physician. This is the important first-hand historical material to understand the development of Japanese dietetic herbalism in early Edo and its dietotherapy culture.

  4. CoRoT’s first seven planets: An overview*

    Directory of Open Access Journals (Sweden)

    Barge P.

    2011-07-01

    Full Text Available The up to 150 day uninterrupted high-precision photometry of about 100000 stars – provided so far by the exoplanet channel of the CoRoT space telescope – gave a new perspective on the planet population of our galactic neighbourhood. The seven planets with very accurate parameters widen the range of known planet properties in almost any respect. Giant planets have been detected at low metallicity, rapidly rotating and active, spotted stars. CoRoT-3 populated the brown dwarf desert and closed the gap of measured physical properties between standard giant planets and very low mass stars. CoRoT extended the known range of planet masses down-to 5 Earth masses and up to 21 Jupiter masses, the radii to less than 2 Earth radii and up to the most inflated hot Jupiter found so far, and the periods of planets discovered by transits to 9 days. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planet-host-star-metallicity relation then the one found by radial-velocity search programs. Finally the properties of the CoRoT-7b prove that terrestrial planets with a density close to Earth exist outside the Solar System. The detection of the secondary transit of CoRoT-1 at the 10−5-level and the very clear detection of the 1.7 Earth radii of CoRoT-7b at 3.5 10−4 relative flux are promising evidence of CoRoT being able to detect even smaller, Earth sized planets.

  5. Techno-economic investigation of alternative propulsion plants for Ferries and RoRo ships

    International Nuclear Information System (INIS)

    Livanos, George A.; Theotokatos, Gerasimos; Pagonis, Dimitrios-Nikolaos

    2014-01-01

    Highlights: • Alternative Diesel and Gas engine propulsion plants of Ferries and RoRos were studied. • Special focus on marine Natural Gas burning engines and ship waste heat recovery systems. • Significant savings in annual operating costs were predicted in the case of Natural Gas engines. • Environmental and economic optimum propulsion plant alternative was proposed in a specific case study. - Abstract: In this paper, the main alternative propulsion plants based on reciprocating internal combustion engines of a ferry or RoRo ship operating in routes that include Emission Control Areas (ECAs) are comparatively assessed. Specifically, a dual fuel engine propulsion plant is compared with a conventional Diesel engine plant. For both cases, the installation of a waste heat recovery system, which covers a part of the ship electric energy demand, is also considered. The ship main DF engines are assumed to operate using LNG and a small amount of MDO for initiating combustion, whereas low sulphur MDO was regarded as the fuel for the case of the Diesel engine plant. The installation of Selective Catalytic Reduction (SCR) after-treatment unit for reducing the NOx emissions for the case of Diesel engines plant is also taken into account. The propulsion plants were modelled under steady state conditions, and the simulation results were analysed in order to compare the alternative configurations. Furthermore, the Energy Efficiency Design Index (EEDI) values were calculated and the two examined propulsion system cases were compared on EEDI basis. Finally, the Life Cycle Cost for each alternative propulsion plant was calculated and used for completing an economic evaluation of the Dual fuel propulsion plant versus the conventional designs applied in ferries

  6. The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799

    International Nuclear Information System (INIS)

    Walton, M.I.; Bleehen, N.M.; Workman, P.; Cambridge Univ.

    1985-01-01

    The nitroimidazole radiosensitizer Ro 03-8799 and the N-oxide Ro 31-0313 were dissolved in buffered solution and given i.v. to inbred male mice. Drug concentrations in whole blood, blood plasma and urine were determined by MPLC. Ro 03 8799 is rapidly cleared and extensively metabolised. Ro 31-0313 is reduced back to Ro 03-8799 by whole blood. The pharmacological and toxicological consequences of this are unknown. (UK)

  7. The feasibility of nanofiltration membrane bioreactor (NF-MBR)+reverse osmosis (RO) process for water reclamation: Comparison with ultrafiltration membrane bioreactor (UF-MBR)+RO process.

    Science.gov (United States)

    Tay, Ming Feng; Liu, Chang; Cornelissen, Emile R; Wu, Bing; Chong, Tzyy Haur

    2018-02-01

    This study examines the feasibility of a novel nanofiltration membrane bioreactor (NF-MBR) followed by reverse osmosis (RO) process for water reclamation at 90% recovery and using an ultrafiltration MBR (UF-MBR)+RO as baseline for comparison. Both MBRs adopted the same external hollow fiber membrane configurations and operating conditions. The collected permeates of the MBRs were subsequently fed to the respective RO systems. The results showed that the NF-MBR (operated at a constant flux of 10 L/m 2 h) achieved superior MBR permeate quality due to enhanced biodegradation and high rejection capacity of the NF membrane, leading to lower RO fouling rates (∼3.3 times) as compared to the UF-MBR. Further analysis indicated that the cake layer fouling that caused the cake-enhanced osmotic pressure (CEOP) effect contributed predominantly to the transmembrane pressure (TMP) increase in the NF-MBR, while irreversible pore fouling was the major reason for UF membrane fouling. Furthermore, it was found that the biopolymers (i.e., organics with MW > 10 kDa) were the main components present in the foulants of the NF/UF membranes and RO membranes. The analysis indicated that the NF-MBR + RO system at recovery of 90% has comparable energy consumption as the UF-MBR + RO system at recovery of 75%. Our findings proved the feasibility of the NF-MBR + RO for water reclamation at a high recovery rate. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. From State-controlled to Polycentric Governance in Forest Landscape Restoration: The Case of the Ecological Forest Purchase Program in Yong'an Municipality of China.

    Science.gov (United States)

    Long, Hexing; Liu, Jinlong; Tu, Chengyue; Fu, Yimin

    2018-07-01

    Forest landscape restoration is emerging as an effective approach to restore degraded forests for the provision of ecosystem services and to minimize trade-offs between conservation and rural livelihoods. Policy and institutional innovations in China illustrate the governance transformation of forest landscape restoration from state-controlled to polycentric governance. Based on a case study of the Ecological Forest Purchase Program in Yong'an municipality, China's Fujian Province, this paper explores how such forest governance transformation has evolved and how it has shaped the outcomes of forest landscape restoration in terms of multi-dimensionality and actor configurations. Our analysis indicates that accommodating the participation of multiple actors and market-based instruments facilitate a smoother transition from state-centered to polycentric governance in forest landscape restoration. Governance transitions for forest landscape restoration must overcome a number of challenges including ensurance of a formal participation forum, fair participation, and a sustainable legislative and financial system to enhance long-term effectiveness.

  9. AstRoMap European Astrobiology Roadmap.

    Science.gov (United States)

    Horneck, Gerda; Walter, Nicolas; Westall, Frances; Grenfell, John Lee; Martin, William F; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R; Rettberg, Petra; Capria, Maria Teresa

    2016-03-01

    The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems • Research Topic 2: Origins of Organic Compounds in Space • Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life • Research Topic 4: Life and Habitability • Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system.

  10. Konstruiranje ročaja hidravličnih klešč

    OpenAIRE

    Žižek, Tomaž

    2015-01-01

    V diplomskem delu je opisan potek konstruiranja ročaja hidravličnih klešč za odstranjevanje ločnega podporja v Premogovniku Velenje. Predstavljeni so vsi pomembnejši koraki, in sicer modeliranje klešč, modeliranje ročaja, numerični rezultati, izbira najustreznejše oblike ročaja ter predstavitev rezultatov ustreznega modela. Diplomsko delo zajema tudi izbiro ustreznega materiala, postopek izdelave ter podatke za pravilno varjenje ročaja na ohišje klešč. Numerični preračuni so opravljeni v pro...

  11. Detection of small-size planetary candidates with CoRoT data

    Directory of Open Access Journals (Sweden)

    Moutou C.

    2011-02-01

    Full Text Available With the discovery of CoRoT-7b, the first transiting super-Earth, the CoRoT space mission has shown the capability to detect short-period rocky planets around solar-like stars. By performing a blind test with real CoRoT light curves, we want to establish the detection threshold of small-size planets in CoRoT data. We investigate the main obstacles to the detection of transiting super-Earths in CoRoT data, notably the presence of short-time scale variability and hot pixels.

  12. USA uus ÜRO saadik alustas pealetungi / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2005-01-01

    Ameerika Ühendriikide uus ÜRO suursaadik John Bolton nõuab 190 liikmesriigile saadetud kirjas ÜRO reformikavades suurte ja oluliste muudatuste tegemist: reformikavast peaks USA arvates kustutama vähemalt 400 paragrahvi

  13. Ilves osaleb ÜRO Peaassamblee 62. istungjärgul

    Index Scriptorium Estoniae

    2007-01-01

    President Toomas Hendrik Ilves osaleb New Yorgis ÜRO peaassamblee 62. istungjärgu töös. Eesti riigipea osaleb ka ÜRO korraldatud kliimamuutuste konverentsil, kohtub ÜRO peasekretäri ja Makedoonia, Slovakkia ning Bosnia ja Hertsegoviina presidendiga, samuti filantroop George Sorosega ning osaleb Baltimaade riigipeade kohtumisel. T.H. Ilves külastab ka Columbia Ülikooli ning osaleb New Yorgi Eesti haridusseltsi korraldatud vastuvõtul New Yorgi Eesti Majas. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  14. The Dushak–Erekdag Survey of roAp Stars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... The search of roAp stars at Mt. Dushak–Erekdag Observatory was started in 1992 using the 0.8m Odessa telescope equipped with a two-star high-speed photometer. We have observed more than a dozen stars so far and discovered HD 99563 as roAp star while BD+8087 is suspected to have rapid ...

  15. Radiosensitization of mouse spermatogenic stem cells by Ro-07-0582

    International Nuclear Information System (INIS)

    Suzuki, N.; Withers, R.; Hunter, N.

    1977-01-01

    The hypoxic character of the spermatogenic stem cells of the mouse testis was investigated by measuring the effect on radiosensitivity of treatment with the hypoxic cell radiosensitizer, Ro-07-0582 or hyperbaric oxygen (30 psi). The D 0 values obtained were 181 (161-207) rad for irradiation alone, 140 (133-148) rad for irradiation after treatment with Ro-07-0582, and about 100 rad for irradiation in the presence of hyperbaric oxygen. Ro-07-0582 alone was slightly cytotoxic. The results demonstrate that mouse spermatogenic stem cells are radiosensitized by Ro-07-0582 or hyperbaric oxygen and are not as well oxygenated as other normal tissues

  16. RoMPS concept review automatic control of space robot

    Science.gov (United States)

    1991-01-01

    The Robot operated Material Processing in Space (RoMPS) experiment is being performed to explore the marriage of two emerging space commercialization technologies: materials processing in microgravity and robotics. This concept review presents engineering drawings and limited technical descriptions of the RoMPS programs' electrical and software systems.

  17. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius

    Science.gov (United States)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.

    2009-10-01

    Aims: We report the discovery of very shallow (Δ F/F ≈ 3.4× 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as caused by a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods: We used CoRoT colours information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy, and preliminary results from radial velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star were derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. Results: We examined all conceivable cases of false positives carefully, and all the tests support the planetary hypothesis. Blends with separation >0.40´´or triple systems are almost excluded with a 8 × 10-4 risk left. We conclude that, inasmuch we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 ± 3 × 10-5 day and a radius of Rp = 1.68 ± 0.09 R_Earth. Analysis of preliminary radial velocity data yields an upper limit of 21 M_Earth for the companion mass, supporting the finding. Conclusions: CoRoT-7b is very likely the first Super-Earth with a measured radius. This object illustrates what will probably become a common situation with missions such as Kepler, namely the need to establish the planetary origin of transits in the absence of a firm radial velocity detection and mass measurement. The composition of CoRoT-7b remains loosely constrained without a precise mass. A very high surface temperature on its irradiated face, ≈1800-2600 K at the substellar point, and a very low one, ≈50 K, on its dark face assuming no atmosphere, have been derived. The CoRoT space mission, launched on 27

  18. 77 FR 23806 - Manning Rail, Inc.-Acquisition and Operation Exemption-Manning Grain Company

    Science.gov (United States)

    2012-04-20

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35607] Manning Rail, Inc.--Acquisition and Operation Exemption--Manning Grain Company Manning Rail, Inc. (MRI), a noncarrier, has filed a verified notice of exemption \\1\\ under 49 CFR 1150.31 to acquire from Manning Grain Company (MGC) and...

  19. News Agency Website Agenda on Religion. Comparative Analysis on Mediafax.ro and Agerpres.ro

    Directory of Open Access Journals (Sweden)

    Aurelia Ana Vasile

    2016-06-01

    Full Text Available According to the “Global Index of Religiosity and Atheism” (WIN-Gallup International, 27 July 2012, retrieved 24 August 2012, which was a global 2012 poll, the reports label 59% of the world's population as “religious” and 36% as not religious, including 13% who are atheists, with a 9% decrease in religious belief from 2005. Thereto, religion is an important issue of inherent influence in the media nowadays. Despite the ongoing secularization process that we are facing these days, humans still feel the need to refer to religion within their attempt to construct one’s own outlook on life, and to make some sense out of existence in general (Max Weber, 19202. A comparative content analysis on Mediafax.ro and Agerpres.ro, performed for an almost nine-and-a-half-month time span (1st January to 13th October 2015, showed interesting facts on how press agency journalists relate to religion as a media topic, both in terms of quality (key words and key topics and in terms of quantity. A comparison between the Orthodox religion of the majority of the Romanians, and other denominations, also accounted for intriguing research findings.

  20. Planetary transit candidates in CoRoT LRa01 field

    DEFF Research Database (Denmark)

    Carone, L.; Gandolfi, D.; Cabrera, J.

    2012-01-01

    We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. We acquired and analyzed 7470 chromatic and 3938 monochromatic...... lightcurves. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. (2 data files)....

  1. Validation of Robotic Surgery Simulator (RoSS).

    Science.gov (United States)

    Kesavadas, Thenkurussi; Stegemann, Andrew; Sathyaseelan, Gughan; Chowriappa, Ashirwad; Srimathveeravalli, Govindarajan; Seixas-Mikelus, Stéfanie; Chandrasekhar, Rameella; Wilding, Gregory; Guru, Khurshid

    2011-01-01

    Recent growth of daVinci Robotic Surgical System as a minimally invasive surgery tool has led to a call for better training of future surgeons. In this paper, a new virtual reality simulator, called RoSS is presented. Initial results from two studies - face and content validity, are very encouraging. 90% of the cohort of expert robotic surgeons felt that the simulator was excellent or somewhat close to the touch and feel of the daVinci console. Content validity of the simulator received 90% approval in some cases. These studies demonstrate that RoSS has the potential of becoming an important training tool for the daVinci surgical robot.

  2. Cuentos ashaninka del r??o Peren??

    OpenAIRE

    Plasencia Soto, Rommel; S??nchez V??squez, Melisa

    2009-01-01

    La memoria ind??gena de los pueblos amaz??nicos del Per?? de hoy, es mostrada en cuatro relatos registrados en la comunidad de Mariscal C??ceres en el valle del r??o Peren?? de la selva central peruana.

  3. man theerasilp

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. MAN THEERASILP. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 42. Synthesis and characterization of SPIO-loaded PEG- b -PS micelles as contrast agent for long-term nanoparticle-based MRI phantom · MAN THEERASILP WITAYA ...

  4. Coupling of RO-MSF hybrid desalination plants with nuclear reactors

    International Nuclear Information System (INIS)

    Al-Sulaiman, Khalil; Al-Mutaz, Ibrahim S.

    1999-01-01

    Full text.Reverse osmosis (RO) and multistage flash (MSF) desalination are the most widely commercial available processes. MSF utilizes stream in the brine heater as a primary source of energy. RO is derived mainly by electricity that pumps the feed water against the mambranes. Steam and electricity and be produced easily by nuclear reactors. Nuclear reactors may be coupled with deslination plants (MSF, RO or combined (hybrid) RO/MSF configuration). This integrated plant will be capable of producing power and water at reasonable cost. The capital and operating cost will be reduced and the excess power can be efficiently utilized. Maintenance and operating cost will drop significantly. In this paper, a techno-economic study of hybrid reverses osmosis /multistage flash desalination will be carried. The proposed configuration (hybrid RO/MSF) coupled with nuclear reactor is considered the most appropriate candidate system for the application of dual-purpose nuclear desalination plants. the design parameters for such a desalination hybrid system will be the applied pressure and recovery for reverse osmosis plant and the number of stages and the heat transfer areas for multistage flash plant

  5. Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjogren's syndrome

    DEFF Research Database (Denmark)

    Pelck, R.; Manthorpe, R.; Locht, Henning

    2008-01-01

    OBJECTIVE: To compare sensitivity and specificity of autoantibodies to alpha-fodrin with conventional anti-Ro and anti-La antibodies in patients with primary Sjogren's syndrome (pSS). Data on internal organ manifestations were correlated with presence of autoantibodies. METHODS: We collected...... clinical and laboratory data from 321 patients with pSS (Copenhagen criteria), of which 205 fulfilled the new American-European 2002 consensus criteria. Sera were tested for autoantibodies against alpha-fodrin and recombinant Ro-52, Ro-60, and La proteins. RESULTS: Antibodies to alpha-fodrin were...

  6. "Det man hører, er man selv"

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2015-01-01

    ”Det man hører, er man selv” er Danmarks Radios P3s yderst velkendte slogan. Det dukkede op i begyndelsen af (20)00erne som opfindsom og populær afspejling af en moderne forståelse af den rolle musik og medieforbrug spiller for den voksne dansker. Denne artikel handler ikke om P3 som musikkanal...

  7. Douglas R.O. Morrison

    CERN Multimedia

    2001-01-01

    Douglas R.O. Morrison 1929 - 2001 Douglas' friends and colleagues are warmly invited to join in a memorial gathering on Friday, 23 March 2001 at 16.00 hours in the CERN Main Auditorium Some colleagues will pay tribute to Douglas' scientific achievements and to his role in leading the collaborations:   Welcome, short CV The 'hadron times' The 'neutrino times' Recent activities Collaborations The 'social environment' A book of condolence will be available. The gathering will conclude with refreshments in the Salle des Pas Perdus.

  8. Sõjaraport õõnestab ÜRO usaldusväärsust / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2011-01-01

    ÜRO Gaza sõda puudutavas raportis kritiseeritakse nii Iisraeli kui ka Palestiina islamistlikku äärmusrühmitust Hamas. ÜRO inimõiguste uurija Richard Goldstone leiab, et raport on siiski puudulik, kuna praegu omab ÜRO juba rohkem infot Gaza sõja kohta

  9. Fellow's Apéro

    CERN Multimedia

    Staff Association

    2017-01-01

    Let's get together, meet each other, exchange experiences and ideas, and share useful information on CERN and the Staff Association. Join us for Fellow's Apéro, organised by the Staff Association on Tuesday 21 February at 16.30 in Restaurant 1. There will be drinks and snacks for everybody! We look forward to seeing you there! Please confirm your participation on Doodle http://doodle.com/poll/skvm7ucm2z78i6bt or alternatively on Facebook https://www.facebook.com/events/1862757017340069/. Your delegates in the Staff Association, Barbora & Jiri

  10. Clinical and Pathological Roles of Ro/SSA Autoantibody System

    Directory of Open Access Journals (Sweden)

    Ryusuke Yoshimi

    2012-01-01

    Full Text Available Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE and Sjögren's syndrome (SS. Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

  11. Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

    Science.gov (United States)

    Kryštůfková, Olga; Barbasso Helmers, Sevim; Venalis, Paulius; Malmström, Vivianne; Lindroos, Eva; Vencovský, Jiří; Lundberg, Ingrid E

    2014-10-10

    Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis, but the mechanisms behind their production are not known. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We investigated expression of the receptors for BAFF in muscle tissue in relation to anti-Jo-1 and anti-Ro52/anti-Ro60 autoantibodies and type-I IFN markers. Muscle biopsies from 23 patients with myositis selected based on autoantibody profile and 7 healthy controls were investigated for expression of BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Nineteen samples were assessed for plasma (CD138) and B-cell (CD19) markers. The numbers of positive cells per area were compared with the expression of plasmacytoid dendritic cell (pDC) marker blood dendritic cell antigen-2 (BDCA-2) and IFNα/β-inducible myxovirus resistance-1 protein (MX-1). BAFF-R, BCMA and TACI were expressed in five, seven and seven patients, respectively, and more frequently in anti-Jo-1-positive and/or anti-Ro52/anti-Ro60-positive patients compared to controls and to patients without these autoantibodies (P = BAFF-R: 0.007, BCMA: 0.03 and TACI: 0.07). A local association of receptors with B and plasma cells was confirmed by confocal microscopy. The numbers of CD138-positive and BCMA-positive cells were correlated (r = 0.79; P = 0.001). Expression of BDCA-2 correlated with numbers of CD138-positive cells and marginally with BCMA-positive cells (r = 0.54 and 0.42, respectively; P = 0.04 and 0.06, respectively). There was a borderline correlation between the numbers of positively stained TACI cells and MX-1 areas (r = 0.38, P = 0.08). The expression

  12. Impact of RO-desalted water on distribution water qualities.

    Science.gov (United States)

    Taylor, J; Dietz, J; Randall, A; Hong, S

    2005-01-01

    A large-scale pilot distribution study was conducted to investigate the impacts of blending different source waters on distribution water qualities, with an emphasis on metal release (i.e. corrosion). The principal source waters investigated were conventionally treated ground water (G1), surface water processed by enhanced treatment (S1), and desalted seawater by reverse osmosis membranes (RO). Due to the nature of raw water quality and associated treatment processes, G1 water had high alkalinity, while S1 and RO sources were characterized as high sulfate and high chloride waters, respectively. The blending ratio of different treated waters determined the quality of finished waters. Iron release from aged cast iron pipes increased significantly when exposed to RO and S1 waters: that is, the greater iron release was experienced with alkalinity reduced below the background of G1 water. Copper release to drinking water, however, increased with increasing alkalinity and decreasing pH. Lead release, on the other hand, increased with increasing chloride and decreasing sulfate. The effect of pH and alkalinity on lead release was not clearly observed from pilot blending study. The flat and compact corrosion scales observed for lead surface exposed to S1 water may be attributable to lead concentration less than that of RO water blends.

  13. ÜRO rahuvalvemissiooni juhtinud brasiillane leiti Haiti hotellist surnult / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2006-01-01

    ÜRO Haiti rahuvalvemissiooni juht Urano Teixeira da Matta Bacellar sooritas enesetapu. ÜRO rahuvalvemissioon MINUSTAH on Haitil 2005. aastast pärast nelja-aastast eemalolekut, samas jätkub seal vägivald

  14. The Dushak–Erekdag Survey of roAp Stars Tatyana Dorokhova ...

    Indian Academy of Sciences (India)

    South-African Astronomical Observatory (SAAO). Details of the discovery and further studies are given in Kurtz (1990) and Kurtz & Martinez (2000). Some roAp stars have multiple modes of pulsations and they are valuable for asteroseismological studies. Out of the 32 known roAp stars so far, about 84% were discovered in ...

  15. Transiting exoplanets from the CoRoT space mission . VI. CoRoT-Exo-3b: the first secure inhabitant of the brown-dwarf desert

    Science.gov (United States)

    Deleuil, M.; Deeg, H. J.; Alonso, R.; Bouchy, F.; Rouan, D.; Auvergne, M.; Baglin, A.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Bruntt, H.; Bordé, P.; Collier Cameron, A.; Csizmadia, Sz.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Schneider, J.; Shporer, A.; Wuchterl, G.; Zucker, S.

    2008-12-01

    Context: The CoRoT space mission routinely provides high-precision photometric measurements of thousands of stars that have been continuously observed for months. Aims: The discovery and characterization of the first very massive transiting planetary companion with a short orbital period is reported. Methods: A series of 34 transits was detected in the CoRoT light curve of an F3V star, observed from May to October 2007 for 152 days. The radius was accurately determined and the mass derived for this new transiting, thanks to the combined analysis of the light curve and complementary ground-based observations: high-precision radial-velocity measurements, on-off photometry, and high signal-to-noise spectroscopic observations. Results: CoRoT-Exo-3b has a radius of 1.01 ± 0.07 R_Jup and transits around its F3-type primary every 4.26 days in a synchronous orbit. Its mass of 21.66 ± 1.0 M_Jup, density of 26.4 ± 5.6 g cm-3, and surface gravity of logg = 4.72 clearly distinguish it from the regular close-in planet population, making it the most intriguing transiting substellar object discovered so far. Conclusions: With the current data, the nature of CoRoT-Exo-3b is ambiguous, as it could either be a low-mass brown-dwarf or a member of a new class of “superplanets”. Its discovery may help constrain the evolution of close-in planets and brown-dwarfs better. Finally, CoRoT-Exo-3b confirms the trend that massive transiting giant planets (M ≥ 4 M_Jup) are found preferentially around more massive stars than the Sun. The CoRoT space mission, launched on December 27th 2006, has been developed and is operating by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Table of the COROT photometry is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http

  16. High-efficient full-duplex WDM-RoF system with sub-central station

    Science.gov (United States)

    Liu, Anliang; Yin, Hongxi; Wu, Bin

    2018-05-01

    With an additional sub-central station (S-CS), a high-efficient full-duplex radio-over-fiber (RoF) system compatible with the wavelength-division-multiplexing technology is proposed and experimentally demonstrated in this paper. To improve the dispersion tolerance of the RoF system, the baseband data format for the downlink and an all-optical down-conversion approach for the uplink are employed. In addition, this RoF system can not only make full use of the fiber link resources but also realize the upstream transmission without any local light sources at remote base stations (BSs). A 10-GHz RoF experimental system with a 1.25-Gb/s rate bidirectional transmission is established based on the S-CS structure. The feasibility and reliability of this RoF system are verified through eye diagrams and bit error rate (BER) curves experimentally obtained.

  17. [Expression and clinical significance of CD45RO in laryngeal carcinoma tissue].

    Science.gov (United States)

    Li, Manyi; Liu, Jishengi; Zhou, Hui; Wu, Wenying; Xiao, Gensheng; Yu, Yafeng; Guo, Lingchuan

    2014-03-01

    To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma, and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy. The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mucos was detected by immunohistochemical S-P method. The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes 0.713, P < 0.05) and tumor sites (r = -0.750, P < 0.05), but it have no notable difference with pathology differentiation, age, infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer. (1) The expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. (2) It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. (3) It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. (4) Other than UICC-TNM stage, pathology differentiation, it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.

  18. From the rights of man to the human rights: Man - nation - humanity

    Directory of Open Access Journals (Sweden)

    Zaharijević Adriana

    2008-01-01

    Full Text Available The insistence on the fact that human rights and the rights of man (codified in The Universal Declaration of Human Rights and Declaration of the Rights of Man and of the Citizen, respectively are not one and the same, which could be deduced from the notion of man common to both terms, is the key thesis of this text. By developing this motive, I try to determine the following: that the notion of man, by definition inclusive and abstractly non-discriminative term, is in fact established on tacit exclusions in the time of its inception (Enlightenment revolutinary era, and it was only upon these exclusions that the term man could have signified "the free and equal". Although the parallel or simultaneous evolution and implementation of the rights of man and national rights might seem contradictory, I seek to demonstrate that this paradox is only ostensible, arguing that the notion of man is itself limited and exclusionary, and is therefore compatible with the exclusivity which is the conditio sine qua non of nation. The consequences of nationalism - World Wars, primarily - proved that the conception of liberty and equality, based on the conception of fraternity of men (white European males, and of partial democracy pretending to be universal, cannot be maintained any further. Codification of universal human rights represents a reaction to this internal discrepancy inasmuch as it is a reaction to the destructiveness of all kinds of nationalisms. The notion of life, developed in this text, corresponds to the fundamental requirement for the right to life (as the first and the most basic of all human rights, which no longer belongs to "man", but to everyone.

  19. ÜRO asesekretäri kriitika USA suunal ajas viimase marru / Liise Lehtsalu

    Index Scriptorium Estoniae

    Lehtsalu, Liise

    2006-01-01

    ÜRO asesekretär Malloch Brown kritiseeris oma kõnes USA tahtmatust teavitada ameeriklasi ÜRO osast USA välispoliitikas. USA ÜRO-suursaadiku John Boltoni reageering Browni märkustele. Lisa: Rikaste ja vaeste riikide vastuolud

  20. Man's Evolutionary Future

    Science.gov (United States)

    Dobzhansky, Theodosius

    1972-01-01

    Man can aspire to control his evolution and direct it towards goals which he finds good, salutary, worth living for....The one most 'natural' thing for man is to modify nature by means of his knowledge." (Author/AL)

  1. RoHS Compliance - Is the Global Electronics Industry Ready?

    OpenAIRE

    Head, Marieke; Hróarsson, Hallur

    2006-01-01

    RoHS is an EU directive that was proposed along with the WEEE Directive in 2002 as a part of a plan to promote extended producer responsibility within the electronics industry. Together, these two directives seek to make electrical and electronic equipment easier to manage both in terms of environmental impacts and recycling. The RoHS Directive seeks to remove lead, cadmium, mercury, hexavalent chromium and two brominated flame retardants from all consumer electrical equipment. This paper dea...

  2. Planetary transit candidates in the CoRoT-SRc01 field

    DEFF Research Database (Denmark)

    Erikson, A.; Santerne, A.; Renner, S.

    2012-01-01

    Context. CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effort...... is undertaken to classify these candidates. Aims. We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. Methods. We acquired...... and analyzed 7470 chromatic and 3938 monochromatic lightcurves. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. Results. Fifty-one stars were classified...

  3. Transiting exoplanets from the CoRoT space mission. IV. CoRoT-Exo-4b: a transiting planet in a 9.2 day synchronous orbit

    Science.gov (United States)

    Aigrain, S.; Collier Cameron, A.; Ollivier, M.; Pont, F.; Jorda, L.; Almenara, J. M.; Alonso, R.; Barge, P.; Bordé, P.; Bouchy, F.; Deeg, H.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Gillon, M.; Guillot, T.; Hatzes, A.; Lammer, H.; Lanza, A. F.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Paetzold, M.; Pinte, C.; Queloz, D.; Rauer, H.; Rouan, D.; Schneider, J.; Wuchter, G.; Zucker, S.

    2008-09-01

    CoRoT, the first space-based transit search, provides ultra-high-precision light curves with continuous time-sampling over periods of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this Letter, we report the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability about each transit, the transit light curve was analysed to determine the transit parameters. A discrete autocorrelation function method was used to derive the rotation period of the star from the out-of-transit light curve. We determine the periods of the planetary orbit and star's rotation of 9.20205 ± 0.00037 and 8.87 ± 1.12 days respectively, which is consistent with this being a synchronised system. We also derive the inclination, i = 90.00_-0.085+0.000 in degrees, the ratio of the orbital distance to the stellar radius, a/Rs = 17.36-0.25+0.05, and the planet-to-star radius ratio R_p/R_s=0.1047-0.0022+0.0041. We discuss briefly the coincidence between the orbital period of the planet and the stellar rotation period and its possible implications for the system's migration and star-planet interaction history. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Figures 1, 4 and 5 are only available in electronic form at http://www.aanda.org

  4. MO-AB-204-01: IHE RO Overview

    International Nuclear Information System (INIS)

    Hadley, S.

    2016-01-01

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity

  5. Radial velocity follow-up of CoRoT transiting exoplanets

    Directory of Open Access Journals (Sweden)

    Deleuil M.

    2011-02-01

    Full Text Available We report on the results from the radial-velocity follow-up program performed to establish the planetary nature and to characterize the transiting candidates discovered by the space mission CoRoT. We use the SOPHIE at OHP, HARPS at ESO and the HIRES at Keck spectrographs to collect spectra and high-precision radial velocity (RV measurements for several dozens different candidates from CoRoT. We have measured the Rossiter-McLaughlin effect of several confirmed planets, especially CoRoT-1b which revealed that it is another highly inclined system. Such high-precision RV data are necessary for the discovery of new transiting planets. Furthermore, several low mass planet candidates have emerged from our Keck and HARPS data.

  6. WE-B-Exhibit Hall-01: Ask the RO-ILS Experts

    Energy Technology Data Exchange (ETDEWEB)

    Ezzell, G [Mayo Clinic Arizona, Phoenix, AZ (United States); Sanscrainte, E [Clarity PSO, Chicago, IL (United States); Tomlinson, C [ASTRO, Fairfax, VA (United States)

    2015-06-15

    Have a question about RO-ILS: Radiation Oncology Incident Learning System™, or interested in learning more? Sponsored by the American Society for Radiation Oncology (ASTRO) and AAPM, RO-ILS is the only medical specialty society-sponsored incident learning system for radiation oncology. It facilitates safer and higher quality care in radiation oncology by providing a mechanism for shared learning in a secure and non-punitive environment. Please join our RO-ILS experts for a question and answer session on Wednesday, July 15th at 8:30 in the Partners in Solutions Room in Exhibit Hall C. Our experts include: Gary Ezzell, PhD, Mayo Clinic Arizona, [Brett Miller, Phillip Beron, and Derek Brown], Emily Sanscrainte from Clarity PSO and Cindy Tomlinson, MPP, ASTRO.

  7. ÜRO teatel peavad toidukriisi eest vastutama rikkad riigid / Liisi Poll

    Index Scriptorium Estoniae

    Poll, Liisi, 1980-

    2008-01-01

    ÜRO peasekretär Ban Ki-Moon kutsus ÜRO põllumajandus- ja toiduorganisatsiooni erakorralisel toidukriisi-teemalisel tippkohtumisel Roomas riike üles vähendama ekspordipiiranguid ja imporditariife, et toiduvarude nappust vähendada. Vt. samas: Kohtumise poliitilised häbiplekid

  8. Thematic trip: "Save Roşia MontanÄă"

    Science.gov (United States)

    Eugenia, Marcu

    2015-04-01

    The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

  9. Hvor må man gå?

    DEFF Research Database (Denmark)

    Baaner, Lasse

    2014-01-01

    færdsel på anden mands grund kan også have hjemmel i en servitut. Reglerne giver anledning til en masse stridigheder og er vanskelige at følge for de fleste af os. I Sverige og Norge har man allemandsret, men ikke i Danmark. Her skal man som mountainbiker, hundelufter, nøgenbader eller kajakroer følge...... nogle ret detaljerede regler, når man færdes på veje og afveje i Guds natur. For at vurdere, om man må færdes på et givent areal, skal man bruge en række informationer. Nogle af dem fi ndes ude i landskabet, mens andre fi ndes ved computeren. Kan man lave en adgangs-app, så man kan se, hvor man må...... færdes? Eller bare en app, som giver en mulighed for at vurderee, hvor man må færdes? Hvilke informationer kan man se on location og hvilke online? Kan der skabes online adgang til den nødvendige information, eller må man skilte sig ud af problemerne? Reglerne er jo – ligesom hastighedsbegrænsninger på...

  10. Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus.

    Science.gov (United States)

    Millard, T P; Ashton, G H S; Kondeatis, E; Vaughan, R W; Hughes, G R V; Khamashta, M A; Hawk, J L M; McGregor, J M; McGrath, J A

    2002-02-01

    The Ro 60 kDa protein (Ro60 or SSA2) is the major component of the Ro ribonucleoprotein (Ro RNP) complex, to which an immune response is a specific feature of several autoimmune diseases. The genomic organization and any sequence variation within the DNA encoding Ro60 are unknown. To characterize the Ro60 gene structure and to assess whether any sequence alterations might be associated with serum anti-Ro antibody in subacute cutaneous lupus erythematosus (SCLE), thus potentially providing new insight into disease pathogenesis. The cDNA sequence for Ro60 was obtained from the NCBI database and used for a BLAST search for a clone containing the entire genomic sequence. The intron-exon borders were confirmed by designing intronic primer pairs to flank each exon, which were then used to amplify genomic DNA for automated sequencing from 36 caucasian patients with SCLE (anti-Ro positive) and 49 with discoid LE (DLE, anti-Ro negative), in addition to 36 healthy caucasian controls. Heteroduplex analysis of polymerase chain reaction (PCR) products from patients and controls spanning all Ro60 exons (1-8) revealed a common bandshift in the PCR products spanning exon 7. Sequencing of the corresponding PCR products demonstrated an A > G substitution at nucleotide position 1318-7, within the consensus acceptor splice site of exon 7 (GenBank XM001901). The allele frequencies were major allele A (0.71) and minor allele G (0.29) in 72 control chromosomes, with no significant differences found between SCLE patients, DLE patients and controls. The genomic organization of the DNA encoding the Ro60 protein is described, including a common polymorphism within the consensus acceptor splice site of exon 7. Our delineation of a strategy for the genomic amplification of Ro60 forms a basis for further examination of the pathological functions of the Ro RNP in autoimmune disease.

  11. The oldest man ever?

    DEFF Research Database (Denmark)

    Wilmoth, J; Skytthe, A; Friou, D

    1996-01-01

    This article summarizes recent findings in a case study of exceptional longevity. CM, a resident of San Rafael, California, was 114 years old in August 1996. He is the first properly verified case of a 114-year-old man in human history (although a few women have been known to live longer). Our...... is accurate. Based on the available information, it also seems a reasonable conjecture that he may be the oldest man alive today and perhaps the oldest man who has ever lived. This study documents an extreme example of human longevity and records characteristics of the man's life that may provide clues about...

  12. Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    DEFF Research Database (Denmark)

    Rouan, D.; Parviainen, H.; Moutou, C.

    2012-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search...... to be 7 Gyr, not far from the transition to subgiant, in agreement with the rather large stellar radius. The two features of a significant eccentricity of the orbit and of a fairly high density are fairly uncommon for a hot Jupiter. The high density is, however, consistent with a model of contraction...... is more than a few 105, a value that is the lower bound of the usually expected range. Even if CoRoT-23b  features a density and an eccentricity that are atypical of a hot Jupiter, it is thus not an enigmatic object....

  13. Man of Fire.

    Science.gov (United States)

    Phipps, Helene Juarez

    1993-01-01

    The themes of Jose Clemente Orozco's murals, several of which are found on U.S. college campuses, are as relevant today as they were during the Mexican Revolution. Orozco (1883-1949) painted the world as he saw it, portraying corruption, violence, and man's inhumanity to man. (LP)

  14. Experimental Study of Advanced Treatment of Coking Wastewater Using MBR-RO Combined Process

    Science.gov (United States)

    Zhang, Lei; Hwang, Jiannyang; Leng, Ting; Xue, Gaifeng; Chang, Hongbing

    A membrane bioreactor-reverse osmosis (MBR-RO) combined process was used for advanced treatment of coking wastewater from secondary biological treatment. MBR and RO units' treatment efficiency for the pollution removal were conducted, and effects of raw water conductivity and trans-membrane pressure on water yield and desalination rate in RO unit were investigated in detail. The experimental results proved that MBR-RO combined process ran steadily with good treatment effect, which could obtain stable effluent water quality and met the requirement of "Design Criterion of the Industrial Circulating Cooling Water Treatment" (GB 50050-2007).

  15. Rich Man, Poor Man: Developmental Differences in Attributions and Perceptions

    Science.gov (United States)

    Sigelman, Carol K.

    2012-01-01

    In an examination guided by cognitive developmental and attribution theory of how explanations of wealth and poverty and perceptions of rich and poor people change with age and are interrelated, 6-, 10-, and 14-year-olds (N = 88) were asked for their causal attributions and trait judgments concerning a rich man and a poor man. First graders, like…

  16. Sensitization by SR-2508 plus Ro 03-8799

    International Nuclear Information System (INIS)

    Stone, H.B.; Luu, Y.H.; Lam, K.N.

    1986-01-01

    The primary toxicity of Ro 03-8799 is a central nervous system toxicity, whereas that of SR-2508 is a peripheral neuropathy. The feasibility of reducing overall toxicity while maintaining maximal radiosensitization by using the two sensitizers together was tested. The LD50/2 of Ro 03-8799 was 0.68 mg/g body wt (mg/gbw) after intravenous (i.v.) administration, and that of SR-2508 was 4.4 mg/gbw after i.v. administration. When both drugs were given together in equitoxic proportions, the LD50/2 was 0.45 mg of Ro 03-8799 plus 2.9 mg of SR-2508/gbw. These doses are 66% of the respective LD50/2 values of the drugs when given separately. Radiosensitization was evaluated using in vivo-in vitro assays with EMT6/SF tumors in BALB/c mice. At drug doses between 10 and 60% of the LD50/2, sensitization was generally maximal and similar to that from misonidazole, but there was less sensitization below this dose, both with the drugs given separately and together. If chronic toxicities of these drugs overlap as do the acute toxicities there will be little or no additional benefit from using these drugs in combination, compared to using them separately

  17. Reference Japanese man

    International Nuclear Information System (INIS)

    Tanaka, Giichiro

    1985-01-01

    To make real and accurate dose assessment method so far, it is necessitated to provide ''Reference Japanese Man'' based on anotomical, physiological and biochemical data of Japanese people instead of the Reference Man presented in ICRP Publications 23 and 30. This review describes present status of researched for the purpose of establishing of Reference Japanese Man. The Reference Japanese Man is defined as a male or female adult who lives in Japan with a Japanese life-style and food custom. His stature and body weight, and the other data was decided as mean values of male or female people of Japan. As for food custom, Japanese people take significantly smaller amount of meat and milk products than Western people, while larger intake amount of cereals and marine products such as fish or seaweeds. Weight of organs is a principal factor for internal dose assessment and mean values for living Japanese adult has been investigated and the value employable for dose assessment for organs and tissues are shown. To employ these values of Reference Japanese Man, it should be taken into account of age. Metabolic parameters should also be considered. Iodine metabolism in Japanese is quite different from that of Western people. The above-mentioned data are now tentatively employing in modification of table of MIRD method and others. (Takagi, S.)

  18. N K Man

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. N K Man. Articles written in Bulletin of Materials Science. Volume 37 Issue 1 February 2014 pp 19-25. Influence of preparation conditions on superconducting properties of Bi-2223 thin films · N T Mua A Sundaresan N K Man D D Dung · More Details Abstract Fulltext PDF.

  19. Geografická výročí

    Czech Academy of Sciences Publication Activity Database

    Martínek, Jiří

    2017-01-01

    Roč. 36, č. 2 (2017), s. 69-72 ISSN 1213-1075 Institutional support: RVO:67985963 Keywords : Czech geography * personalities * anniversaries Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  20. Med-Ro Hybrid desalination as option to supply fresh water in BABEL Islands Province

    International Nuclear Information System (INIS)

    Siti Alimah; Sudi Ariyanto; June Mellawati; Budiarto

    2011-01-01

    Med-Ro hybrid desalination systems are combining both thermal (Med) and membrane (Ro) desalination processes with power generation systems. This configuration has more economical and operational benefits in comparison with single desalination plant. Hybrid configurations are characterized by flexibility in operation, specific energy consumption (33.50 kWh/m 3 ) is lower than Med (36.54 kWh/m 3 ) and high plant availability. The objective of study is to analyze the Med-Ro hybrid desalination as an option to add supply fresh water in Babel Islands Province, in terms of technology and economy aspects. The result of study showed that adopting nuclear power plants as dual-purpose for power generation and producing fresh water is has economic competitiveness than fossil-fired generation plants. Med-Ro hybrid configuration, with feed Ro from heat rejection of Med system is suitable as fresh water supply add option because increase of Ro feed temperature will increase flux. Economic analysis of water cost are performed using the Deep-3.2. Water cost of hybrid Med-Ro desalination with energy of NPP (0.581 $/m ) is lower than that of Med water cost (0.752 $/m ) . Water cost of hybrid Med-Ro with energy of NPP (0.581 $/m ) is lower than that of water cost of energy with fossil-fired generation plants (0.720 $/m 3 ). (author)

  1. The Nature of Man and Its Implications.

    Science.gov (United States)

    Pedrini, D. T.; Gregory, Lura N.

    The many problems presented by the nature of man and in studying man are the focus of this paper which attempts to place these problems in perspective in terms of the past and future. The enigma facing man, that man must study man, is related in an introduction. Freud's, Adler's, and Jung's developments in the study of the nature of man are…

  2. VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT, 2009-2016)

    Science.gov (United States)

    COROT Team

    2014-03-01

    CoRoT is a space astronomy mission devoted to the study of the variability with time of stars brightness, with an extremely high accuracy (100 times better than from the ground), on very long durations (up to 150 days) and a very high duty cycle (more than 90%). The mission was led by CNES in association with four french laboratories, and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite is composed of a PROTEUS platform (the 3rd in the serie), and a unique instrument: a stellar photometer. It has been launched on December 27th 2006 by a Soyuz Rocket, from Baikonour. The mission has lasted almost 6 years (the nominal 3 years duration and a 3 years extension) and has observed more than 160 000 stars. It stopped to send data suddenly on November 2nd 2012. CoRoT is performing Ultra High Precision Photomery of Stars to detect and characterise the variability of their luminosity with two main directions: - variability of the object itself: oscillations, rotation, magnetic activity - variability due to external causes as bodies in orbit around the star: planets and stars The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transit in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The bright star mode dedicated to very precise seismology of a small sample of bright and closeby stars (data presented in file momentarily named "astero.dat", but should change in the near future to to "bright star.dat") - The faint star mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer (data presented in momentarily named "exo.dat" but should change in the near

  3. The Green Man

    Science.gov (United States)

    Watson-Newlin, Karen

    2010-01-01

    The Jolly Green Giant. Robin Hood. The Bamberg Cathedral. Tales of King Arthur. Ecology. What do they have in common? What legends and ancient myths are shrouded in the tales of the Green Man? Most often perceived as an ancient Celtic symbol as the god of spring and summer, the Green Man disappears and returns year after year, century after…

  4. 46 CFR 151.45-3 - Manning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD... HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgment of the Officer in Charge, Marine Inspection, such manning is...

  5. The Black Man in American Society.

    Science.gov (United States)

    Framingham Public Schools, MA.

    GRADE OR AGES: Junior high school. SUBJECT MATTER: The black man in American society. ORGANIZATION AND PHYSICAL APPEARANCE: There are four major parts each with an overview. The four parts concern a) the African heritage of the black man, b) the American exploitation of the black man, c) the black man's contribution to American society, d) the…

  6. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

    Science.gov (United States)

    Gao, Jingjing; Yao, Licheng; Xia, Tingting; Liao, Xuebin; Zhu, Deyu; Xiang, Ye

    2018-04-01

    The human kynurenine 3-monooxygenase (hKMO) is a potential therapeutic target for neurodegenerative and neurologic disorders. Inhibition of KMO by Ro 61-8048, a potent, selective, and the most widely used inhibitor of KMO, was shown effective in various models of neurodegenerative or neurologic disorders. However, the molecular basis of hKMO inhibition by Ro 61-8048 is not clearly understood. Here, we report biochemistry studies on hKMO and crystal structures of an hKMO homolog, pfKMO from Pseudomonas fluorescens, in complex with the substrate l-kynurenine and Ro 61-8048. We found that the C-terminal ∼110 aa are essential for the enzymatic activity of hKMO and the homologous C-terminal region of pfKMO folds into a distinct, all-α-helical domain, which associates with the N-terminal catalytic domain to form a unique tunnel in proximity to the substrate-binding pocket. The tunnel binds the Ro 61-8048 molecule, which fills most of the tunnel, and Ro 61-8048 is hydrogen bonded with several completely conserved residues, including an essential catalytic residue. Modification of Ro 61-8048 and biochemical studies of the modified Ro 61-8048 derivatives suggested that Ro 61-8048 inhibits the enzyme in an allosteric manner by affecting the conformation of the essential catalytic residue and by blocking entry of the substrate or product release. The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which should facilitate further optimization of Ro 61-8048 and the development of new inhibitory drugs to hKMO.-Gao, J., Yao, L., Xia, T., Liao, X., Zhu, D., Xiang, Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

  7. RO-75, Reverse Osmosis Plant Design Optimization and Cost Optimization

    International Nuclear Information System (INIS)

    Glueckstern, P.; Reed, S.A.; Wilson, J.V.

    1999-01-01

    1 - Description of problem or function: RO75 is a program for the optimization of the design and economics of one- or two-stage seawater reverse osmosis plants. 2 - Method of solution: RO75 evaluates the performance of the applied membrane module (productivity and salt rejection) at assumed operating conditions. These conditions include the site parameters - seawater salinity and temperature, the membrane module operating parameters - pressure and product recovery, and the membrane module predicted long-term performance parameters - lifetime and long flux decline. RO75 calculates the number of first and second stage (if applied) membrane modules needed to obtain the required product capacity and quality and evaluates the required pumping units and the power recovery turbine (if applied). 3 - Restrictions on the complexity of the problem: The program does not optimize or design the membrane properties and the internal structure and flow characteristics of the membrane modules; it assumes operating characteristics defined by the membrane manufacturers

  8. Simple, Accurate, Low-cost RO Science with the Iridium-NEXT Satellite Constellation

    Science.gov (United States)

    Meehan, T.; Mannucci, A. J.

    2011-12-01

    Over the last decade, a disparate collection of GNSS-RO instruments have been measuring the refractivity of the Earth's ionosphere and atmosphere. These measurements have proven to be robust and precise data sets for operational weather, climate and geospace sciences. Future GNSS-RO weather and science will most benefit from a large number of profiles (10000+/day), with lower latency and greater accuracy in the lowest 5 km altitude. For weather, latencies below 90 minutes are required, 30 minutes desired. Space weather latency requirements are more stringent, with 15 minutes being a long sought goal. Climate studies benefit from averaging measurements uniformly distributed over the Earth, acquired over decades, with local time sampling errors minimized by dense coverage or well designed orbits. There's much more of course, because space GNSS science is still nascent but with gathering momentum among the international community. Although individual GNSS-RO instruments are relatively cheap as space hardware goes, growing the measurement density can be costly when a dozen or more are required for a single program. In this presentation, we propose a novel technique for greatly reducing the cost of a constellation of GNSS-RO instruments and discuss the science trade-offs of this approach versus the more traditional GNSS-RO designs.

  9. RO5: proposal of a relevant facility in nuclear fusion research

    International Nuclear Information System (INIS)

    Pouzo, J.

    1987-01-01

    The RO5 project is a proposal of an experiment in nuclear fusion research based in a plasma focus device. The main research scopes of the experiment, with respect to the scaling law foundations and the identification of the main nuclear reaction mechanisms, are discussed. A practical aim of the experiment is to reach 10 14 - 10 15 neutrons/pulse from D-D reactions in the plasma focus using a 3 MJ capacitor bank. It represents an energy efficience of around a 5% when D-T mixture is used as filling gas in the reactor (RO5 = Reactor of 5% in energy efficience). A first RO5 design obtained with a 2D snowplow model and taken into account the operation limits recently found, is presented. (author) [pt

  10. Vabariigi President esines ÜRO Peaassambleel

    Index Scriptorium Estoniae

    2007-01-01

    ÜRO Peaassamblee 62. istungjärgul kõneles president Toomas Hendrik Ilves kliimamuutuse, küberjulgeoleku, kriiside reguleerimise ja rahvusvaheliste organisatsioonide koostöö teemadel. Ilmunud ka: Koit 29. sept. 2007, lk. 6; Eesti Elu 28. sept. 2007, lk. 2; ingl. k. Vaba Eesti Sõna 4. okt. 2007, lk. 12, pealk.: The President of the Republic Spoke to the UN General Assembly. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  11. The rights of man and animal experimentation.

    Science.gov (United States)

    Martin, J

    1990-01-01

    Since emotions give contradictory signals about animal experimentation in medical science, man's relationship to animals must be based upon reason. Thomas Aquinas argues that man is essentially different from animals because man's intellectual processes show evidence of an abstract mechanism not possessed by animals. Man's rights arise in association with this essential difference. The consequence is that only man possesses true rights by Aquinas's definition; animals have them only by analogy. However, cruelty to animals is illicit and they should be protected, principally not because they have rights, but because he who is cruel to animals is more likely to be cruel to his fellowman. If there is a need for animal experimentation in science for the good of man, this approach gives philosophical justification for experimentation, since man's well-being must come before that of animals because of his unique possession of rights. However, those experiments should be carried out in the kindest way possible, to promote kindness towards man. To see man as solely part of a biological continuum in competition for rights with those beings close to him biologically, detracts from man's dignity. PMID:2135948

  12. The rights of man and animal experimentation.

    OpenAIRE

    Martin, J

    1990-01-01

    Since emotions give contradictory signals about animal experimentation in medical science, man's relationship to animals must be based upon reason. Thomas Aquinas argues that man is essentially different from animals because man's intellectual processes show evidence of an abstract mechanism not possessed by animals. Man's rights arise in association with this essential difference. The consequence is that only man possesses true rights by Aquinas's definition; animals have them only by analog...

  13. Zonal NePhRO scoring system: a superior renal tumor complexity classification model.

    Science.gov (United States)

    Hakky, Tariq S; Baumgarten, Adam S; Allen, Bryan; Lin, Hui-Yi; Ercole, Cesar E; Sexton, Wade J; Spiess, Philippe E

    2014-02-01

    Since the advent of the first standardized renal tumor complexity system, many subsequent scoring systems have been introduced, many of which are complicated and can make it difficult to accurately measure data end points. In light of these limitations, we introduce the new zonal NePhRO scoring system. The zonal NePhRO score is based on 4 anatomical components that are assigned a score of 1, 2, or 3, and their sum is used to classify renal tumors. The zonal NePhRO scoring system is made up of the (Ne)arness to collecting system, (Ph)ysical location of the tumor in the kidney, (R)adius of the tumor, and (O)rganization of the tumor. In this retrospective study, we evaluated patients exhibiting clinical stage T1a or T1b who underwent open partial nephrectomy performed by 2 genitourinary surgeons. Each renal unit was assigned both a zonal NePhRO score and a RENAL (radius, exophytic/endophytic properties, nearness of tumor to the collecting system or sinus in millimeters, anterior/posterior, location relative to polar lines) score, and a blinded reviewer used the same preoperative imaging study to obtain both scores. Additional data points gathered included age, clamp time, complication rate, urine leak rate, intraoperative blood loss, and pathologic tumor size. One hundred sixty-six patients underwent open partial nephrectomy. There were 37 perioperative complications quantitated using the validated Clavien-Dindo system; their occurrence was predicted by the NePhRO score on both univariate and multivariate analyses (P = .0008). Clinical stage, intraoperative blood loss, and tumor diameter were all correlated with the zonal NePhRO score on univariate analysis only. The zonal NePhRO scoring system is a simpler tool that accurately predicts the surgical complexity of a renal lesion. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Transiting exoplanets from the CoRoT space mission. XVII. The hot Jupiter CoRoT-17b: a very old planet

    Science.gov (United States)

    Csizmadia, Sz.; Moutou, C.; Deleuil, M.; Cabrera, J.; Fridlund, M.; Gandolfi, D.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Carone, L.; Carpano, S.; Cavarroc, C.; Cochran, W.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Endl, M.; Erikson, A.; Ferraz-Mello, S.; Fruth, Th.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

    2011-07-01

    We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of 2.43 ± 0.30 MJup and a radius of 1.02 ± 0.07 RJup, while its mean density is 2.82 ± 0.38 g/cm3. CoRoT-17b is in a circular orbit with a period of 3.7681 ± 0.0003 days. The host star is an old (10.7 ± 1.0 Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain ~380 earth masses of heavier elements. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  15. Bulletproof Black Man

    DEFF Research Database (Denmark)

    Højer, Henrik

    2016-01-01

    Netflix’ kommende serie om den sorte Marvel-helt Luke Cage lander snart – midt i de aktuelle racekonflikter i USA. I GIF-anatomien "Bulletproof Black Man" sætter Henrik Højer serien ind i dens amerikanske kontekst.......Netflix’ kommende serie om den sorte Marvel-helt Luke Cage lander snart – midt i de aktuelle racekonflikter i USA. I GIF-anatomien "Bulletproof Black Man" sætter Henrik Højer serien ind i dens amerikanske kontekst....

  16. Analysis of the Constituents in “Zhu She Yong Xue Shuan Tong” by Ultra High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Preparative High Performance Liquid Chromatography

    Directory of Open Access Journals (Sweden)

    Lin-Lin Wang

    2015-11-01

    Full Text Available “Zhu She Yong Xue Shuan Tong” lyophilized powder (ZSYXST, consists of a series of saponins extracted from Panax notoginseng, which has been widely used in China for the treatment of strokes. In this study, an ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS combined with preparative high performance liquid chromatography (PHPLC method was developed to rapidly identify both major and minor saponins in ZSYXST. Some high content components were removed through PHPLC in order to increase the sensitivity of the trace saponins. Then, specific characteristic fragment ions in both positive and negative mode were utilized to determine the types of aglycone, saccharide, as well as the saccharide chain linkages. As a result, 94 saponins, including 20 pairs of isomers and ten new compounds, which could represent higher than 98% components in ZSYXST, were identified or tentatively identified in commercial ZSYXST samples.

  17. Multiple star systems observed with CoRoT and Kepler

    Directory of Open Access Journals (Sweden)

    Southworth John

    2015-01-01

    Full Text Available The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

  18. Application of indirect immunofluorescent test with an improved HEp-2 substrate tranfected with human Ro60/SSA autoantigens

    International Nuclear Information System (INIS)

    Lv Liangjing; Chen Shunle; Gu Yueying; Shen Nan; Bao Chunde; Wang Yuan; Xue Feng; Ye Peng; Yu Chongzhao

    2006-01-01

    To develop an improved substrate for indirect immunofluorescent test (IIF) to detect anti-Ro/SSA autoantibodies, the human 60-kDa Ro/SSA autoantigens (Ro60) cDNAs were obtained from placental cDNA library using PCR and were cloned into the mammalian expression vectorpEGFP-C1. Then the recombinant plasmids were transfected into HEp-2 cells. We con- firmed the overexpression, localization and antigenicity of fusion proteins in transfected cells by means of fluorescence microscopy, immunoblotting and IIF. HEp-2 and HEp-Ro60 was analyzed by IIF using a panel of 10 precipitinpositive anti-Ro human sera simultaneously. Stable expression of Ro60-GFP (green fluorescent protein) fusion proteins maintained ten more generations. And Ro60-GFP kept the antigenicity of Ro and had its own characteristic immunofluorescent pattern in HEp-Ro60 cells. The transfectants dramatically increased the sensitivity of IIF testing (a mean increase of 6.7-fold in endpoint titer, P<0.01). Eight (8/10) positive an- ti-Ro sera showed characteristic immunofluorescent pattern on HEp-Ro60, including two sera which were antinuclear antibodies (ANA) negative on untransfected HEp-2. IIF-ANA in all healthy sera were negative on HEp-Ro60. As a kind of new substrate of IIF, the Ro60 transfectants can be used to detect anti-Ro antibodies. In addition, transfected HEp-2 cells kept the immunofluorescent property of HEp-2 cells in IIF-ANA tests and could be employed as substrate for the routine IIF-ANA detection. The method improved the sensitivity of IIF-ANA. (authors)

  19. "Det man siger er man selv..."

    DEFF Research Database (Denmark)

    Næsby, Torben; Nørgaard, Britta; Uddholm, Mats

    forhold, der er hermeneutisk, strukturelt og relationelt bestemt. Praksisviden kan ikke være objektiv i gængs forstand, men det behøver ikke at diskvalificere denne viden. Forståelse er altid knyttet til den sag og bundet til den situation man står overfor og i som professionel og som menneske....

  20. The Implementation of Madrasah-Based Management (MBM) at Man 1 and Man 2 Serang City, Banten, Indonesia--A Comparative Study

    Science.gov (United States)

    Muhajir

    2016-01-01

    This study aims to reveal how the real condition of management of Madrasah Aliyah Negeri (MAN) or Islamic Senior High School in Serang is, how the understanding of Madrasah-Based Management (MBM) for the people of MAN 2 and MAN 1 Serang is, and how the implementation of MBM in MAN 2 and MAN 1 Serang. This study has a substantial meaning, both…

  1. Man - Machine Communication

    CERN Document Server

    Petersen, Peter; Nielsen, Henning

    1984-01-01

    This report describes a Man-to-Machine Communication module which together with a STAC can take care of all operator inputs from the touch-screen, tracker balls and mechanical buttons. The MMC module can also contain a G64 card which could be a GPIB driver but many other G64 cards could be used. The soft-ware services the input devices and makes the results accessible from the CAMAC bus. NODAL functions for the Man Machine Communication is implemented in the STAC and in the ICC.

  2. RO unit for canned coffee drink processing line. Shipped to Tone Coca-Cola Bottling Co. Ltd., Ibaraki plant; Coffee line yo RO sochi. Tone Coca-Cola Bottling (kabu) Ibaraki kojo nonyu

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, K. [Ebara Corp., Tokyo (Japan)

    1996-01-20

    The paper introduces an RO unit (reverse osmotic membrane equipment) for producing water holding for the canned coffee drink processing line introduced to the Ibaraki plant of Tone Coca-Cola Bottling Co. The unit aims at reducing hardness components from city water and producing water holding for the coffee drink processing line. The capacity of the unit is 25m{sup 3}/h and the recovery rate is 80%. The unit is composed of a sand filter, an heat exchanger, a pre-filter, RO modules, a treated water tank, chemicals storage tanks, and an RO cleaning unit, which are all for pretreatment. The treated water, into which chlorine is injected, is sent through the existing activated carbon tower and micro filter to the processing line. The RO unit can remove at the same time ion and trihalomethane, pathogens, organic matters which are substances other than hardness components. The continued water bottling is possible with no need for the usual reproduction process, and the maintenance is easy. Because of the high hardness of the supplied raw water, acid is injected at the primary side of the unit for pH regulation to prevent scale deposition in the RO modules. The quality of the treated water well met the specifications. 2 figs., 2 tabs.

  3. On the identity of Dorylaimus robustus de Man

    NARCIS (Netherlands)

    Loof, P.A.A.

    1961-01-01

    The taxonomic position of Dorylaimus robustus de Man, 1876 is fully discussed. It is concluded that D. robustus de Man, 1876 is a synonym of D. stagnalis Dujardin, 1845; also included in this synonymy are D. robustus apud de Man, 1880, apud de Man, 1884 (male, partim) and Labronema robustum (de Man,

  4. A comparative study of Ro 03-8799: racemic mixture and enantiomers

    International Nuclear Information System (INIS)

    Newman, H.F.V.; Bleehen, N.M.; Workman, P.; Dunphy, E.P.; Dische, S.; Saunders, M.I.; Des Rochers, C.; Lenox-Smith, I.; Smithen, C.E.

    1986-01-01

    The maximum single dose of the 2-nitroimidazole hypoxic cell radiosensitiser Ro 03-8799 is limited to 1 g/m 2 by the occurrence of a well characterised acute syndrome of sweating, nausea and mental changes. In an attempt to increase the tolerable dose, the clinical toxicity of the racemic mixture was compared with that of the R- and S-enantiomers of Ro 03-8799. Twelve patients received escalating alternate doses of racemic mixture and R- or S-enantiomer, the dose levels being 0.25 g/m 2 , 0.5 g/m 2 , 0.75 g/m 2 and 1.0 g/m 2 . Careful monitoring of the acute syndrome failed to demonstrate any consistent differences between racemic mixture and either enantiomer. This would suggest that the toxicity is not mediated via any specific central nervous system receptor. It is concluded that separation of Ro 03-8799 into its enantiomers will not enable a clinically useful increase in dosage. (author)

  5. Japanese reference man 1988, 3

    International Nuclear Information System (INIS)

    Tanaka, Gi-ichiro

    1988-01-01

    Quantitative description of physical properties and other characteristics of the human body is one of the basic data for estimating dose equivalent and calculating Annual Limit on Intake of radionuclides. The exact mass weight of organs and tissues are measured from about 1000 autopsy cases of normal Japanese adults and physical properties are obtained from recent Japanese Government publications. Japanese (Asian) Reference Man is completed by establishing the Normal Japanese, harmonizing with Caucasian Reference Man and coinciding with the ICRP Reference Man Task Group members concept. (author)

  6. Exploration of the brown dwarf regime around solar-like stars by CoRoT

    OpenAIRE

    Csizmadia, Szilárd

    2016-01-01

    Aims. A summary of the CoRoT brown dwarf investigations are presented. Methods. Transiting brown dwarfs around solar like stars were studied by using the photometric time-series of CoRoT, and ground based radial velocity measurements. Results. CoRoT detected three transiting brown dwarfs around F and G dwarf stars. The occurence rate of brown dwarfs was found to be 0.20 +/- 0.15% around solar-like stars which is compatible with the value obtained by Kepler-data.

  7. The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

    KAUST Repository

    Salinas-Rodriguez, Sergio G.

    2015-02-18

    Reliable methods for measuring and predicting the fouling potential of reverse osmosis (RO) feed water are important in preventing and diagnosing fouling at the design stage, and for monitoring pre-treatment performance during plant operation. The Modified Fouling Index Ultrafiltration (MFI-UF) constant flux is a significant development with respect to assessing the fouling potential of RO feed water. This research investigates (1) the variables influencing the MFI-UF test at constant flux filtration (membrane pore size, membrane material, flux rate); and (2) the application of MFI-UF into pre-treatment assessment and RO fouling estimation. The dependency of MFI on flux, means that to assess accurately particulate fouling in RO systems, the MFI should be measured at a flux similar to a RO system (close to 20 L/m2/h) or extrapolated from higher fluxes. The two studied membrane materials showed reproducible results; 10% for PES membranes and 6.3% for RC membranes. Deposition factors (amount of particles that remain on the surface of membrane) were measured in a full-scale plant ranging between 0.2 and 0.5. The concept of “safe MFI” is presented as a guideline for assessing pre-treatment for RO systems.

  8. Rožňava ore field - geophysical works

    Directory of Open Access Journals (Sweden)

    Géczy Július

    1998-12-01

    Full Text Available The article prowides a review of geophysical works in the ore field Rožňava conducted up to date. Magnetometric and geoelectric methods and gravimetric measurements have been used. Geophysical works were focused to the solving regional problems whose contribution to the prospecting of vein deposits is not essential.

  9. Imaging benzodiazepine receptors in man with C-11-suriclone and positron emission tomography

    International Nuclear Information System (INIS)

    Frost, J.J.; Dannals, R.F.; Ravert, H.T.; Wilson, A.A.; Links, J.M.; Trifiletti, R.; Snyder, S.H.; Wagner, H.N. Jr.

    1985-01-01

    Suriclone is a potent cyclopyrrolone, anti-anxiety drug which binds to the benzodiazepine receptor complex (BZR) with high affinity. Suriclone binds to a site on the BZR distinct from the site where benzodiazepines bind. The K/sub D/ of suriclone at 37oC is 0.03 nM. C-11-suriclone (SUR) was synthesized by reacting C-CH3I with the appropriate amine precursor. SUR (1 μg/kg) was injected IV into a baboon alone or with 1 mg/kg of Ro-151788, a benzodiazepine antagonist, and serial PET scans of the brain were obtained. High radioactivity concentrations were observed in the cerebral cortex and cerebellum which contain high densities of BZR, intermediate concentrations in thalamus and low concentrations in the striatum. When Ro-151788 was given a uniform distribution of radioactivity was observed; the radioactivity was reduced to ca. 25% of control values in the brain which was contained within the PET slice. SUR (0.2 μg/kg) was next administered to a human subject. From 30-60 minutes after injection high radioactivity concentrations were observed in the cerebral cortex and cerebellum, intermediate concentrations in the thalamus and a low concentration in the caudate. Radioactivity in the cerebral cortex and cerebellum decreased slowly with time, implying that binding of SUR to a high affinity site had occurred. These results demonstrate utility of SUR for measuring binding to the benzodiazepine receptor complex non-invasively in man

  10. MO-AB-204-01: IHE RO Overview [Health Care

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, S. [The University of Michigan (United States)

    2016-06-15

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.

  11. ÜRO - tõeliselt üleilmne foorum / Tiina Intelmann

    Index Scriptorium Estoniae

    Intelmann, Tiina, 1963-

    2007-01-01

    Eesti Vabariigi alaline esindaja ÜRO juures tutvustab maailmaorganisatsiooni põhikirjalisi eesmärke, globaliseerumise mõjusid tegevusele, raskusi rahvusvaheliste kokkulepete täitmisel, rahuvalve ja kohtupidamisega seotud küsimusi ning igapäevatööd

  12. Apoptosis and Redistribution of the Ro Autoantigen in Balb/c Mouse Like in Subacute Cutaneous Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Rafael Herrera-Esparza

    2006-01-01

    Full Text Available In subacute cutaneous lupus eryhematosus (SCLE the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5–30 mJ/cm2 equivalent to a moderate to severe sunburn. Animals were injected with monoclonal anti-Ro antibodies from SCLE patients. Apoptosis was also induced by anti-Fas antibody injection. Skin samples were examined by direct immunofluoresence, by TUNEL, and the expression of caspase 3 by RT-PCR. Major findings of present studies were: 1. UVB irradiation and anti-Fas induced apoptosis of keratinocytes. 2. Apoptosis redistribute the Ro antigen on cell surface and is better triggered by Ro antibody. 3. The caspase 3 inhibitor Ac-DEVD-CMK decreases the availability of Ro autoantigen in epidermis and prevents deposition of anti-Ro. In conclusion, the caspase pathway would be blocked to avoid anti-Ro deposition along skin; this finding would be a prospect in the treatment of SCLE patients.

  13. Transiting exoplanets from the CoRoT space mission

    DEFF Research Database (Denmark)

    Ollivier, M.; Gillon, M.; Santerne, A.

    2012-01-01

    Aims. We report the discovery of CoRoT-16b, a low density hot jupiter that orbits a faint G5V star (mV = 15.63) in 5.3523 ± 0.0002 days with slight eccentricity. A fit of the data with no a priori assumptions on the orbit leads to an eccentricity of 0.33 ± 0.1. We discuss this value and also derive......RoT-16b is a 0.535 −0.083/+0.085 MJ, 1.17 −0.14/+0.16 RJ hot Jupiter with a density of 0.44 −0.14/+0.21 g cm-3. Despite its short orbital distance (0.0618 ± 0.0015 AU) and the age of the parent star (6.73 ± 2.8 Gyr), the planet orbit exhibits significantly non-zero eccentricity. This is very uncommon...

  14. On-line dosing of Ammonium Biflouride for reduction of silica scaling on RO membranes

    Directory of Open Access Journals (Sweden)

    Ehab A. Rashed

    2016-08-01

    The primary goal of this research is to investigate the effectiveness of using Ammonium Biflouride (ABF as an anti-scaling agent in improving the performance of the RO membranes. ABF was used as on-line dosing with different doses for mitigation of scaling caused by silica (SiO2 on RO membranes. To study the efficiency of the anti-scaling agent, Scanning Electron Microscopy & Energy Dispersive X-ray Spectroscopy (SEM–EDS were performed for all phases before and after using the anti-scaling agent on the used RO membrane surface. The main parameters measured were: silica, TDS. Flux loss was observed for the cross-flow RO membrane after filtration. ABF doses used were: 2, 4, and 6 mg/l at constant pH = 6 and the optimum dose was found to be 4 mg/l.

  15. Unit Manning

    National Research Council Canada - National Science Library

    McGinniss, Mike

    2003-01-01

    .... This decision combines two crucial initiatives: first, transforming the Army from an individual soldier replacement system to a unit manning system that enhances cohesion and keeps trained soldiers, leaders, and commanders together longer, thereby...

  16. Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway

    Science.gov (United States)

    Li, Yong; He, Zhi-Cheng; Liu, Qing; Zhou, Kai; Shi, Yu; Yao, Xiao-Hong; Zhang, Xia; Kung, Hsiang-Fu; Ping, Yi-Fang; Bian, Xiu-Wu

    2018-01-01

    Reprogramming energy metabolism is a hallmark of malignant tumors, including glioblastoma (GBM). Aerobic glycolysis is often utilized by tumor cells to maintain survival and proliferation. However, the underlying mechanisms of aerobic glycolysis in GBM remain elusive. Herein, we demonstrated that large intergenic non-coding RNA-RoR (LincRNA-RoR) functioned as a critical suppressor to inhibit the aerobic glycolysis and viability of GBM cells. We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients. Consistently, LincRNA-RoR expression in GBM cells was significantly lower than that in normal glial cells. The aerobic glycolysis of GBM cells, as determined by the measurement of glucose uptake and lactate production, was impaired by LincRNA-RoR overexpression. Mechanistically, LincRNA-RoR inhibited the expression of Rictor, the key component of mTORC2 (mammalian target of rapamycin complex 2), to suppress the activity of Akt pathway and impair the expression of glycolytic effectors, including Glut1, HK2, PKM2 and LDHA. Finally, enforced expression of LincRNA-RoR reduced the proliferation of GBM cells in vitro, restrained tumor growth in vivo, and repressed the expression of glycolytic molecules in GBM xenografts. Collectively, our results underscore LincRNA-RoR as a new suppressor of GBM aerobic glycolysis with therapeutic potential. PMID:29581766

  17. ÜRO peakorterile otsitakse naabrit / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    New Yorki, ÜRO peakorterist lõunasse hakatakse ehitama uut hoonet. Arhitektuurikonkursist on kutsutud osalema: David Childs, Richard Meier ja Peter Eisenmann; Schuman Lichtenstein Claman Efron ja HOK arhitektid; Kohn Pederson Fox, Davis Brody Bond, Toyo Ito ja Rem Koolhaas; Henry Cobb, James Ingo Freed ja Machado & Silvetti Associates; Christian de Portzamparc ja Gary Edward Handel & Associates

  18. A New Method for Detecting and Monitoring Atmospheric Natural Hazards with GPS RO

    Science.gov (United States)

    Biondi, R.; Steiner, A. K.; Rieckh, T. M.; Kirchengast, G.

    2014-12-01

    Global Positioning System (GPS) Radio Occultation (RO) allows measurements in any meteorological condition, with global coverage, high vertical resolution, and high accuracy. With more than 13 years of data availability, RO also became a fundamental tool for studying climate change. We present here the application of RO for detecting and monitoring tropical cyclones (TCs), deep convective systems (CSs) and volcanic ash clouds (ACs).Deep CSs and TCs play a fundamental role in atmospheric circulation producing vertical transport, redistributing water vapor and trace gases, changing the thermal structure of the Upper Troposphere and Lower Stratosphere (UTLS) and affecting climate through overshooting into the stratosphere. Explosive volcanic eruptions produce large ACs dangerous for the aviation and they can impact climate when the ash is injected into the UTLS.The detection of cloud top height, the determination of cloud extent, the discrimination of ACs from CSs clouds and the detection of overshooting are main challenges for atmospheric natural hazards study. We created a reference atmosphere with a resolution of 5° in latitude and longitude, sampled on a 1° x 1° grid, and a vertical sampling of 100 m. We then compared RO profiles acquired during TCs, CSs and ACs to the reference atmosphere and computed anomaly profiles.CSs, TCs and the ACs leave a clear signature in the atmosphere which can be detected by RO. Using RO temperature and bending angle profiles we gain insight into the vertical thermal structure and developed a new method for detecting the cloud top altitude with high accuracy.We have characterized the TCs by ocean basins and intensities, showing that they have a different thermal structure and reach to different altitudes according to the basin. We provide statistics on overshooting frequency, achieving results consistent with patterns found in the literature and demonstrating that RO is well suited for this kind of study. We have analyzed the

  19. CoRoT 101186644 : A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

    NARCIS (Netherlands)

    Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

    2013-01-01

    We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (m$_V$ = 16) candidate revealed an eclipsing binary composed of a late F-type primary (T$_{eff}$ = 6090

  20. CoRoT and Kepler results: Solar-like oscillators

    NARCIS (Netherlands)

    Hekker, S.

    2013-01-01

    The space-borne observatories CoRoT (Convection Rotation and planetary Transits) and Kepler have provided photometric time series data of unprecedented precision for large numbers of stars. These data have revolutionized the fields of transiting exoplanets and asteroseismology. In this review some

  1. EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

    International Nuclear Information System (INIS)

    Deleuil, M.; Meunier, J. C.; Moutou, C.; Surace, C.; Barbieri, M.; Agneray, F.; Granet, Y.; Guterman, P.; Deeg, H. J.; Almenara, J. M.; Debosscher, J.; Hodgkin, S.

    2009-01-01

    Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic plane around CoRoT pointings, with a total area of 209 deg 2 . This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.

  2. 33 CFR 143.407 - Manning.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

  3. A beta skin dose monitor using an Eberline RO-2 ion chamber

    International Nuclear Information System (INIS)

    Jester, W.A.; Levine, S.H.; Lin, T.J.; Hock, R.

    1994-01-01

    The authors have developed a portable beta skin dose monitor that uses an Eberline RO-2trademark ion chamber. The development was based, in part, upon the previous development of a beta skin dose monitor employing silicon detectors. In this current work, the two entrance windows of the RO-2 were replaced by windows having a total mass thickness of 1.74 mg/cm 2 . A two section source-detector holder was constructed. One section fastens to the RO-2 and holds the detector at the right position to determine the contact skin dose from beta emitters located on surfaces. A second section attaches to the first, and provides fixed counting geometry for radioactive samples such as hot particles. The first section also contains a slide mechanism that allows the placement of absorbers of zero (0), 8.38, and 1000 mg/cm 2 between the detector window and the beta source. The detector response to these absorbers allows for the determination of beta skin dose. The system was modeled using a Monte Carlo beta attenuation code computing the beta skin dose to RO-2 detector response as a function of absorber thickness, average beta energy, source diameter and source position. Using the RO-2 reading from each of the three absorber configurations allows the calculation of beta skin dose and the average beta energy. The results of these calculations were confirmed through the use of three massless radioactive beta sources, traceable to the National Institute of Standards and Technology, and several utility-supplied hot particles having well-established contact skin doses. An extrapolation chamber was also used to confirm the results obtained from this monitor. This system is now use at the Pennsylvania Power and Light (PP and L) Company, the project sponsor. ((orig.))

  4. Effect of Watertight Subdivision on Subdivision Index for Medium Size Ro–Ro Passenger Ferries

    Directory of Open Access Journals (Sweden)

    M. Pawlowski

    2017-09-01

    Full Text Available Ro-pax vessels should fulfil the requirements of the current harmonised SOLAS Convention. The study analyses the effect of various ro-pax vessel subdivision arrangements on the subdivision index. A Polish ferry was chosen as a generic ship to perform the study. For illustration of damage survivability, the attained subdivision index A was calculated for a number of modified configurations. The arrangements included single and double sides above and below the car deck, with and without a double buoyant car deck. The conclusions of the study can be used in the design of new ro-pax vessels.

  5. Man-made gemstones; Jinko hoseki

    Energy Technology Data Exchange (ETDEWEB)

    Isogami, M. [Kyocera Corp., Kyoto (Japan)

    2000-01-01

    Birth and development of the man-made gemstones in the 20th century are outlined. Manufacturing gemstones was initiated by the invention of corundum production, followed by production of rubies and sapphires. In 1950 GE Co. synthesized diamonds, after that, most gemstones were manufactured consequently by progress of technologies of single crystal growing and ceramic manufacturing. In the 21st century, steep growth in demand is not expected but it seems to keep steady growth and the importance and necessity of man-made gemstones may be increased because of global environmental issues. Man-made gemstones seem to have both personality and variety of characteristics. (NEDO)

  6. Man Machine Systems in Education.

    Science.gov (United States)

    Sall, Malkit S.

    This review of the research literature on the interaction between humans and computers discusses how man machine systems can be utilized effectively in the learning-teaching process, especially in secondary education. Beginning with a definition of man machine systems and comments on the poor quality of much of the computer-based learning material…

  7. Limits to the presence of transiting circumbinary planets in CoRoT Data

    Science.gov (United States)

    Klagyivik, P.; Deeg, H. J.; Cabrera, J.; Csizmadia, Sz.; Almenara, J. M.

    2017-06-01

    Aims: During its flight phase, from 2007-2012, the CoRoT mission delivered light curves for over 2000 eclipsing binaries. Data from the Kepler mission have proven the existence of several transiting circumbinary planets. While light curves from CoRoT typically have lower precision and shorter coverage, the number of CoRoT targets is similar to that of Kepler and some of the known circumbinary planets could potentially be detected in CoRoT data as well. The aim of this work was to reanalyse the entire CoRoT Data set to search for the presence of circumbinary planets and to derive limits on the abundances of such planets. Methods: We developed a code that removes the signatures of eclipsing binaries from the light curves, and searches for quasi-periodic, transit-like features in the light curves after removal of binary eclipses and instrumental features. The code requires little information on sample systems and can also be used for other space missions, such as Kepler, K2, TESS, and PLATO. The code is broad in the requirements leading to detections, but was tuned to deliver an amount of detections that are manageable in a subsequent, mainly visual, assessment of their origin. Results: We identified three planet candidates in the CoRoT sample whose transits would have arisen from a single pass across the central binary; however, no candidates with transit events from multiple planetary orbits remained. We calculated the upper limits for the number of Jupiter, Saturn-, and Neptune-sized planets in co-planar orbits for different orbital period ranges. We found that there are much fewer giant planets in short periodic orbits around close binary systems than around single stars. Full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A117

  8. 29 CFR 780.305 - 500 man-day provision.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false 500 man-day provision. 780.305 Section 780.305 Labor...) Statutory Provisions § 780.305 500 man-day provision. (a) Section 3(u) of the Act defines man-day to mean “any day during which an employee performs agricultural labor for not less than 1 hour.” 500 man-days...

  9. Understanding Spider-Man: Your Everyday Superhero

    OpenAIRE

    Falk, Nicklas; Blomsterberg, Sofie Amalie; Suciu, Alice Sabrina; Pedersen, Mads Peter; Lucas, Vilhelm

    2014-01-01

    This project focuses on the understanding of Spider-Man, and the morals and ethics that lie behind the choices he makes. Through the Dimensions Philosophy & Science/Text & Sign, this understanding is concluded by looking at ethical theories and comic book analysis. Based on the Ultimate Spider-Man comic book series, the aim is to clarify who Spider-Man is and what causes him to act in certain ways; before and after his realization of power. Some theories used to investigate these area...

  10. 29 CFR 780.317 - Man-day exclusion.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Man-day exclusion. 780.317 Section 780.317 Labor...) Statutory Provisions § 780.317 Man-day exclusion. Section 3(e)(2) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  11. 29 CFR 780.309 - Man-day exclusion.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Man-day exclusion. 780.309 Section 780.309 Labor...) Statutory Provisions § 780.309 Man-day exclusion. Section 3(e)(1) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  12. Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species.

    Science.gov (United States)

    Varty, G B; Hyde, L A; Hodgson, R A; Lu, S X; McCool, M F; Kazdoba, T M; Del Vecchio, R A; Guthrie, D H; Pond, A J; Grzelak, M E; Xu, X; Korfmacher, W A; Tulshian, D; Parker, E M; Higgins, G A

    2005-10-01

    Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198. The aim of this study was to examine the effects of Ro64-6198 in anxiety models across three species: rat, guinea pig, and mouse. In addition, the receptor specificity of Ro64-6198 was studied, using the ORL-1 receptor antagonist, J-113397, and ORL-1 receptor knockout (KO) mice. Finally, neurological studies examined potential side effects of Ro64-6198 in the rat and mouse. Ro64-6198 (3-10 mg/kg) increased punished responding in a rat conditioned lick suppression test similarly to chlordiazepoxide (6 mg/kg). This effect of Ro64-6198 was attenuated by J-113397 (10 mg/kg), but not the mu opioid antagonist, naltrexone (3 mg/kg). In addition, Ro64-6198 (1-3 mg/kg) reduced isolation-induced vocalizations in rat and guinea pig pups. Ro64-6198 (3 mg/kg) increased the proportion of punished responding in a mouse Geller-Seifter test in wild-type (WT) but not ORL-1 KO mice, whereas diazepam (1-5.6 mg/kg) was effective in both genotypes. In rats, Ro64-6198 reduced locomotor activity (LMA) and body temperature and impaired rotarod, beam walking, and fixed-ratio (FR) performance at doses of 10-30 mg/kg, i.e., three to ten times higher than an anxiolytic dose. In WT mice, Ro64-6198 (3-10 mg/kg) reduced LMA and rotarod performance, body temperature, and FR responding, but these same measures were unaffected in ORL-1 KO mice. Haloperidol (0.3-3 mg/kg) reduced these measures to a similar extent in both genotypes. These studies confirm the potent, ORL-1 receptor-mediated, anxiolytic-like effects of Ro64-6198, extending the findings across three species. Ro64-6198 has target-based side effects, although the magnitude of these effects varies across species.

  13. Dispersion and nonlinear effects in OFDM-RoF system

    Science.gov (United States)

    Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

    2010-08-01

    The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

  14. 32 CFR 707.2 - Man overboard lights.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Man overboard lights. 707.2 Section 707.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY NAVIGATION SPECIAL RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two...

  15. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Kelsey Guerreso

    2016-01-01

    Conclusion: It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension.

  16. A Bacterial Biosensor for Oxidative Stress Using the Constitutively Expressed Redox-Sensitive Protein roGFP2

    Directory of Open Access Journals (Sweden)

    Carlos R. Arias-Barreiro

    2010-06-01

    Full Text Available A highly specific, high throughput-amenable bacterial biosensor for chemically induced cellular oxidation was developed using constitutively expressed redox-sensitive green fluorescent protein roGFP2 in E. coli (E. coli-roGFP2. Disulfide formation between two key cysteine residues of roGFP2 was assessed using a double-wavelength ratiometric approach. This study demonstrates that only a few minutes were required to detect oxidation using E. coli-roGFP2, in contrast to conventional bacterial oxidative stress sensors. Cellular oxidation induced by hydrogen peroxide, menadione, sodium selenite, zinc pyrithione, triphenyltin and naphthalene became detectable after 10 seconds and reached the maxima between 80 to 210 seconds, contrary to Cd2+, Cu2+, Pb2+, Zn2+ and sodium arsenite, which induced the oxidation maximum immediately. The lowest observable effect concentrations (in ppm were determined as 1.0 x 10−7 (arsenite, 1.0 x 10−4 (naphthalene, 1.0 x 10−4 (Cu2+, 3.8 x 10−4 (H2O2, 1.0 x 10−3 (Cd2+, 1.0 x 10−3 (Zn2+, 1.0 x 10−2 (menadione, 1.0 (triphenyltin, 1.56 (zinc pyrithione, 3.1 (selenite and 6.3 (Pb2+, respectively. Heavy metal-induced oxidation showed unclear response patterns, whereas concentration-dependent sigmoid curves were observed for other compounds. In vivo GSH content and in vitro roGFP2 oxidation assays together with E. coli-roGFP2 results suggest that roGFP2 is sensitive to redox potential change and thiol modification induced by environmental stressors. Based on redox-sensitive technology, E. coli-roGFP2 provides a fast comprehensive detection system for toxicants that induce cellular oxidation.

  17. Application of monochloramine for wastewater reuse: Effect on biostability during transport and biofouling in RO membranes

    KAUST Repository

    Farhat, Nadia

    2018-02-23

    The rising demand for clean and safe water has increased the interest in advanced wastewater treatment and reuse. Reverse osmosis (RO) can provide reliable and high-quality water from treated wastewater. Biofouling inevitably occurs, certainly with wastewater effluents, resulting in RO performance decline and operational problems. Chlorination of feed water has been commonly applied to limit biological growth. However, chlorine use may lead to a loss of membrane integrity of RO systems. In this study the potential of monochloramine as an alternative for chlorine was studied by (i) evaluating the biological stability of a full-scale wastewater membrane bioreactor (MBR) effluent during transport over 13 km to a full-scale RO plant and (ii) assessing the biofouling control potential in membrane fouling simulator (MFS) and pilot-scale RO installation. Microbial water analysis was performed on samples taken at several locations in the full-scale water reuse system (MBR effluent, during transport, and at the RO inlet and outlet) using a suite of tools including heterotrophic plate counts (HPC), adenosine triphosphate (ATP), flow cytometry (FCM), and 16 S rRNA gene pyrosequencing. Growth potential tests were used to evaluate the effect of monochloramine presence and absence on bacterial growth. Results showed limited changes in the microbial water quality in the presence of monochloramine. MFS studies showed that membrane biofouling could be effectively repressed by monochloramine over prolonged time periods. The normalized salt passage in a pilot RO system with monochloramine dosage was constant over a one year period (data of last 130 days presented), demonstrating that no membrane damage occurred. From this study, it can be concluded that monochloramine dosage in wastewater applications is effective in controlling biofouling in RO systems and maintaining a monochloramine residual during water transport provides biologically stable water.

  18. Symbolism in prehistoric man.

    Science.gov (United States)

    Facchini, F

    2000-12-01

    The aptitude for symbolization, characteristic of man, is revealed not only in artistic representations and funerary practices. It is exhibited by every manifestation of human activity or representation of natural phenomena that assumes or refers to a meaning. We can recognize functional symbolism (tool-making, habitative or food technology), social symbolism, (language and social communication) and spiritual symbolism (funerary practices and artistic expressions). On the basis of these concepts, research into symbolism in prehistoric man allows us to recognize forms of symbolism already in the manifestations of the most ancient humans, starting with Homo habilis (or rudolfensis). Toolmaking, social organization and organization of the territory are oriented toward survival and the life of the family group. They attest to symbolic behaviors and constitute symbolic systems by means of which man expresses himself, lives and transmits his symbolic world. The diverse forms of symbolism are discussed with reference to the different phases of prehistoric humanity.

  19. Construction-man hour estimation for nuclear power plants

    International Nuclear Information System (INIS)

    Paek, J.H.

    1987-01-01

    This study centers on a statistical analysis of the preliminary construction time, main construction time, and total construction man hours of nuclear power plants. The use of these econometric techniques allows the major man hour driving variables to be identified through multivariate analysis of time-series data on over 80 United States nuclear power plants. The analysis made in this study provides a clearer picture of the dynamic changes that have occurred in the man hours of these plants when compared to engineering estimates of man hours, and produces a tool that can be used to project nuclear power plant man hours

  20. TU-CD-BRD-00: Incident Learning / RO-ILS

    International Nuclear Information System (INIS)

    2015-01-01

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

  1. TU-CD-BRD-00: Incident Learning / RO-ILS

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

  2. Teleoperators: Man's Machine Partners

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R.

    1972-01-01

    This booklet is about teleoperators, a class of machines that augment man rather than replace him. Teleoperators have the ability to add to man's strength, his reach, and his ability to work in hostile environments.

  3. Man-made climate change: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Holopainen, E [Helsinki Univ. (Finland). Dept. of Meteorology

    1996-12-31

    The first major man-made environmental problem was the soil acidification, caused primarily by the massive industrial emissions of sulphur dioxide. Then came the problem of ozone depletion, caused by the emissions of man-made halocarbons. More recently, the possibility of man-made climate change has received a lot of attention. These three man-made problems are interconnected in fundamental ways and require for their solution interdisciplinary and international approach. Narrowing of the scientific uncertainties connected with the problems mentioned above can be expected through international `Global Change` programmes such as the World Climate Research Programme (WCRP) and the International Geosphere-Biosphere Programme (IGBP). Periodic assessments of the type produced by the IPCC will clearly be needed. Also in the future such assessments should form the scientific basis for international negotiations and conventions on the climate change issue

  4. Man-made climate change: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Holopainen, E. [Helsinki Univ. (Finland). Dept. of Meteorology

    1995-12-31

    The first major man-made environmental problem was the soil acidification, caused primarily by the massive industrial emissions of sulphur dioxide. Then came the problem of ozone depletion, caused by the emissions of man-made halocarbons. More recently, the possibility of man-made climate change has received a lot of attention. These three man-made problems are interconnected in fundamental ways and require for their solution interdisciplinary and international approach. Narrowing of the scientific uncertainties connected with the problems mentioned above can be expected through international `Global Change` programmes such as the World Climate Research Programme (WCRP) and the International Geosphere-Biosphere Programme (IGBP). Periodic assessments of the type produced by the IPCC will clearly be needed. Also in the future such assessments should form the scientific basis for international negotiations and conventions on the climate change issue

  5. Solar fired combined RO/MED desalination plant integrated with electrical power grid

    International Nuclear Information System (INIS)

    Alrobaei, H.

    2006-01-01

    Currently, there is a strong demand for efficient seawater desalination plants, which can meet the tougher environment regulation and energy saving requirements. From this standpoint the present work was undertaken to include proposed scheme (solar Fired Combined Reverse Osmosis (ROY Multi-Effect Distillation (MED) Seawater desalination Plant (SCDP) integrated with electrical power grid (EPG)) for repowering and modification of the conventional grid connected RO desalination plants. The model of SCDP during sunny periods may be applied to the following modes operation: *Full solar desalination (i.e. solar thermal and electrical power generation in solar plant is elivered to the desalination process and the surplus electricity is fed into EPG). *Hybrid solar desalination (I.e. a small share of the electrical power consumption for desalination process compensated by EPG). During cloudly periods and at night the SCDP operates as a conventional RO desalination plant. To establish the range, in which solar energy for seawater desalination would be competitive to fossil energy and investigates the potential effect of the proposed scheme on the repowering effectiveness, mathematical model has been developed. The repowered effectiveness, mathematical model has been developed.The repowered effectiveness in optaimizing model was characterized by the condition of attaining maximum fuel saving in the EPG. The study result shows the effectiveness of proposed scheme for modification and repowering the RO plant. For the case study. (SCDP with maual share of solar electrical power generation 67.4%) the economical effect amount 138.9 ton fuel/year for each MW design thermal energy of parabolic solar collectors array and the corresponding decrease in exhaust gases emission (Nitrogen oxides (NO x ) 0.55 ton/year.MW, carbon dioxides (CO2) 434.9 ton/year.MW). Moreover, implementation of combined RO/MED design for repowering and modification of conventional grid connected RO plant will

  6. The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

    Science.gov (United States)

    Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

    2010-09-01

    We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

  7. The driving mechanism of roAp stars

    Energy Technology Data Exchange (ETDEWEB)

    Dupret, M-A [Observatoire de Paris, LESIA, CNRS UMR 8109, 5 place J. Janssen, 92195 Meudon (France); Theado, S; Noels, A [Institut d' Astrophysique et Geophysique, Universite de Liege (Belgium)], E-mail: MA.dupret@obspm.fr

    2008-10-15

    We analyse in detail the driving mechanism of roAp stars and present the theoretical instability strip predicted by our models with solar metallicity. A particular attention is given to the interpretation of the role played by the different eigenfunctions in the stabilization of the modes at the red edge of the instability strip. The gradient of temperature in the H{sub I} opacity bump appears to play a major role in this context. We also consider the particular and complex role played by the shape of the eigenfunctions (location of the nodes, ...)

  8. The driving mechanism of roAp stars

    International Nuclear Information System (INIS)

    Dupret, M-A; Theado, S; Noels, A

    2008-01-01

    We analyse in detail the driving mechanism of roAp stars and present the theoretical instability strip predicted by our models with solar metallicity. A particular attention is given to the interpretation of the role played by the different eigenfunctions in the stabilization of the modes at the red edge of the instability strip. The gradient of temperature in the H I opacity bump appears to play a major role in this context. We also consider the particular and complex role played by the shape of the eigenfunctions (location of the nodes, ...).

  9. "A Is A": Spider-Man, Ayn Rand, and What Man Ought to Be

    OpenAIRE

    Brühwiler, Claudia Franziska

    2014-01-01

    In 1979, writer Tom DeFalco was paired with artist and cocreator of Spider-Man, Steve Ditko, to work on an issue of Machine Man, one of the many superheroes populating the universe of Marvel Comics. Instead of the usual introduction and business chatter, Ditko challenged DeFalco during a first conversation: "Are you Tom? What gives you the right to write about heroes?" (Tucker 2012). By the time of this exchange, Ditko had not only (co-) created and continued numerous superhero stories, rangi...

  10. Dinâmica evolutiva em roças de caboclos amazônicos

    Directory of Open Access Journals (Sweden)

    Paulo Sodero Martins

    2005-04-01

    Full Text Available AS ROÇAS DE CABOCLOS são unidades de agricultura de derruba e queima de populações tradicionais nas terras firmes dos trópicos brasileiros, geralmente associados com florestas. Elas são derivadas de sistemas indígenas com algumas modificações introduzidas pelos africanos e portugueses. Neste trabalho, analisamos a estrutura de comunidade dessas roças e o papel dos fatores biológicos e culturais em manter e aumentar a variabilidade genética na mais importante espécie plantada nas roças, a mandioca (Manihot esculenta. Há um alto grau de diversidade nas roças e muitas espécies que estão normalmente presentes, como mandioca, batata-doce, inhame, ariá, araruta, cupá, amendoim, apresentam o que tem sido chamado de habilidade de combinação ecológica, o que significa que elas otimizam o uso dos fatores ambientais e recursos, minimizando a sobreposição de suas arquiteturas. A variabilidade de mandioca é ampliada pelo banco de sementes em ��reas previamente ocupadas, cruzamentos interespecíficos e intervarietais, facilitada pelo arranjo das plantações escolhido pelos caboclos. Depois de criada, a variabilidade é fixada através de clonagem vegetativa, o método de reprodução comum não apenas da mandioca, mas também de outras espécies da roça, a maioria perene e apresentando "disjunção agronômica", ou seja, reprodução e produção efetivada por diferentes órgãos da planta.THE "ROÇAS DE CABOCLOS" are the slash-and-burn agricultural units of traditional populations dwelling in the lowlands of the Brazilian Tropics, generally in association with forests. They are derived from the indigenous system with some modifications introduced by the Africans and Portuguese. In this paper we analyse the community structure of the "roças" and the role of biological and cultural factors in maintaining and augmenting the genetic variability in the most important species planted in roças, the cassava (Manihot esculenta. There

  11. Results of a customer-based, post-market surveillance survey of the HeRO access device.

    Science.gov (United States)

    Fusselman, Maureen

    2010-08-01

    In order to supplement post-market surveillance data on the HeRO vascular access device, a non-scientific customer survey was conducted to obtain quantitative data from dialysis providers caring for patients implanted with the device. Dialysis nurses involved in the care of HeRO patients were contacted in order to obtain post-implant device performance information for 10% of patients implanted with the device at the time of the survey. Thirty-eight dialysis units with a total of 65 HeRO patients participated in the survey. The total duration of HeRO device use was 348.4 months with an average use of 5.4 months. Thirty-eight of the 65 HeRO patients (58.5%) were reported to not have experienced any performance issues. There were 28 device performance incidents reported for the remaining 27 patients included in the survey. Occlusion was the single most commonly reported device-related performance issue with 18 patients (27.7%) experiencing 25 occlusive episodes. The majority of the patients who had an occlusion (66.7%) only experienced one occlusive event. Infections occurred in 4 patients (6.2%) with an overall infection rate of 0.38 per 1,000 patient days. Post-market clinical experience during the first 18 months of commercialization of the HeRO device were in line with expectations based on the results from initial clinical studies with the device. Device occlusion remains the most commonly reported performance issue with the reported rate in this survey less than that which was reported in earlier published studies with the device.

  12. Nuclear fuel: the thinking man's alternative

    International Nuclear Information System (INIS)

    Chamberlain, N.

    1989-01-01

    'Nuclear Fuel ' The Thinking Man's Alternative' is the title of the 55th Melchett Lecture given by Neville Chamberlain, Chief Executive of British Nuclear Fuels plc. This article is based on the address, the essence of which is that the case for nuclear power should be based upon an appreciation of the totality and sophistication of man's handling of his energy needs - not on a glib catch-phase or on a simple political dogma or on an economic argument. Arguments in favour of nuclear power were discussed. The conclusion was that nuclear energy is the thinking man's alternative because only thinking man could have and can develop it; secondly, only thinking men should be authorized to exploit and control it; thirdly, a thinking person will appreciate that, properly thought out and controlled, it must be the most important source of future energy for the benefit of mankind. (author)

  13. Human capabilities in space. [man machine interaction

    Science.gov (United States)

    Nicogossian, A. E.

    1984-01-01

    Man's ability to live and perform useful work in space was demonstrated throughout the history of manned space flight. Current planning envisions a multi-functional space station. Man's unique abilities to respond to the unforeseen and to operate at a level of complexity exceeding any reasonable amount of previous planning distinguish him from present day machines. His limitations, however, include his inherent inability to survive without protection, his limited strength, and his propensity to make mistakes when performing repetitive and monotonous tasks. By contrast, an automated system does routine and delicate tasks, exerts force smoothly and precisely, stores, and recalls large amounts of data, and performs deductive reasoning while maintaining a relative insensitivity to the environment. The establishment of a permanent presence of man in space demands that man and machines be appropriately combined in spaceborne systems. To achieve this optimal combination, research is needed in such diverse fields as artificial intelligence, robotics, behavioral psychology, economics, and human factors engineering.

  14. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  15. Cost analysis of the Hemodialysis Reliable Outflow (HeRO) Graft compared to the tunneled dialysis catheter.

    Science.gov (United States)

    Al Shakarchi, Julien; Inston, Nicholas; Jones, Robert G; Maclaine, Grant; Hollinworth, David

    2016-04-01

    In end-stage renal disease patients with central venous obstruction, who have limited vascular access options, the Hemodialysis Reliable Outflow (HeRO) Graft is a new alternative with a lower incidence of complications and longer effective device life compared to tunneled dialysis catheters (TDCs). We undertook an economic analysis of introducing the HeRO Graft in the UK. A 1-year cost-consequence decision analytic model was developed comparing management with the HeRO Graft to TDCs from the perspective of the National Health Service in England. The model comprises four 3-month cycles during which the vascular access option either remains functional for hemodialysis or fails, patients can experience access-related infection and device thrombosis, and they can also accrue associated costs. Clinical input data were sourced from published studies and unit cost data from National Health Service 2014-15 Reference Costs. In the base case, a 100-patient cohort managed with the HeRO Graft experienced 6 fewer failed devices, 53 fewer access-related infections, and 67 fewer device thromboses compared to patients managed with TDCs. Although the initial device and placement costs for the HeRO Graft are greater than those for TDCs, savings from the lower incidence of device complications and longer effective device patency reduces these costs. Overall net annual costs are £2600 for each HeRO Graft-managed patient compared to TDC-managed patients. If the National Health Service were to reimburse hemodialysis at a uniform rate regardless of the type of vascular access, net 1-year savings of £1200 per patient are estimated for individuals managed with the HeRO Graft. The base case results showed a marginal net positive cost associated with vascular access with the HeRO Graft compared with TDCs for the incremental clinical benefit of reductions in patency failures, device-related thrombosis, and access-related infection events in a patient population with limited options for

  16. Man-systems distributed system for Space Station Freedom

    Science.gov (United States)

    Lewis, J. L.

    1990-01-01

    Viewgraphs on man-systems distributed system for Space Station Freedom are presented. Topics addressed include: description of man-systems (definition, requirements, scope, subsystems, and topologies); implementation (approach, tools); man-systems interfaces (system to element and system to system); prime/supporting development relationship; selected accomplishments; and technical challenges.

  17. Typhoon Man-Yi

    Science.gov (United States)

    2007-01-01

    Typhoon Man-Yi was pummeling the Japanese island of Okinawa with winds between 230 and 295 kilometers per hour (125-160 knots, 144-184 miles per hour) and heavy rain on the morning of July 13, 2007, when the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Terra satellite captured this image. The immense storm covered hundreds of kilometers with spiraling bands of thunderstorms, though it had lost the distinctive cloud-free eye it exhibited the day before. Typhoons are common in Japan, but powerful typhoons usually strike the island nation later in the year. The Japan Meteorological Agency said that Man-Yi is the fourth typhoon of the 2007 season and may be the most powerful ever observed in the northwest Pacific in July, reported Kyodo News. The Joint Typhoon Warning Center expected the typhoon to strike Kyushu, a southern Japanese island, on July 14, and then curve northeast along the eastern shore of Japan. By the time the storm reaches Tokyo on July 15, it should be degraded to a tropical storm. As of July 13, Typhoon Man-Yi had injured eight and flooded twenty houses in Okinawa, and forced airlines to cancel hundreds of flights, said Kyodo News. The storm was expected to bring heavy rain to Japan's Pacific coast. NASA image created by Jesse Allen, using data provided courtesy of the MODIS Rapid Response team.

  18. Man-machine supervision

    International Nuclear Information System (INIS)

    Montmain, J.

    2005-01-01

    Today's complexity of systems where man is involved has led to the development of more and more sophisticated information processing systems where decision making has become more and more difficult. The operator task has moved from operation to supervision and the production tool has become indissociable from its numerical instrumentation and control system. The integration of more and more numerous and sophisticated control indicators in the control room does not necessary fulfill the expectations of the operation team. It is preferable to develop cooperative information systems which are real situation understanding aids. The stake is not the automation of operators' cognitive tasks but the supply of a reasoning help. One of the challenges of interactive information systems is the selection, organisation and dynamical display of information. The efficiency of the whole man-machine system depends on the communication interface efficiency. This article presents the principles and specificities of man-machine supervision systems: 1 - principle: operator's role in control room, operator and automation, monitoring and diagnosis, characteristics of useful models for supervision; 2 - qualitative reasoning: origin, trends, evolutions; 3 - causal reasoning: causality, causal graph representation, causal and diagnostic graph; 4 - multi-points of view reasoning: multi flow modeling method, Sagace method; 5 - approximate reasoning: the symbolic numerical interface, the multi-criteria decision; 6 - example of application: supervision in a spent-fuel reprocessing facility. (J.S.)

  19. Human factors and man-machine-interaction

    International Nuclear Information System (INIS)

    Bohr-Bruckmayr, E.

    1985-01-01

    Definitions of the man-machine-interface concept are given. The importance of ergonomics in planning, construction, start-up and operation of a nuclear power plant is highlighted. A comprehensive task analysis is the basis of man-machine-interaction. Personnel performance, work shaping and security are discussed

  20. Plasmodium Infection In Man: A Review | Ekpenyong | Animal ...

    African Journals Online (AJOL)

    Plasmodium infection in man is caused by the bite of an infected female Anopheles mosquito. This results in the disease, malaria. Malaria has serious debilitating effects on man. It adversely affectsman's health, strength and productivity. Here, a review of Plasmodium infection in man including the life cycle transmisson, ...

  1. Some consideration of Japanese standard man value

    International Nuclear Information System (INIS)

    Yoshizawa, Yasuo; Kusama, Tomoko

    1976-01-01

    Numerical values of standard man or reference man is important problem in the field of radiation protection and safety. The standard man values given by ICRP were obtained from European and North American adult data. For that reason, there are some theoretical problems in the application of standard man values to Japanese. The purpose of the present paper is to consider the difference of values between Japanese and standard man. The standard man values are divided into three categories. The first category is the size and weight of the body or organ, the second is the values of elementary composition, and the third is the numerical factors related to metabolic kinetics. It is natural that some values of the second and the third categories have little difference between Japanese and European. On the other hand, there are some differences in the value of the first category, but the differences can calculation in proportional allotment to the body weight. The values concerning the thyroid gland and iodine metabolism are important for radiation protection. It has been foreseen that these values of Japanese are significantly different from standard man. A survey of past reports was carried out with a view to search for normal values of the weight, iodine content, and iodine uptake rate of the thyroid of Japanese. The result of the survey showed that the weight of thyroid are about 19g for adult male and 17g for adult female and that the iodine contents are 12-22mg and iodine uptake rate (fw) is about 0.2. (auth.)

  2. Magna Carta Libertatum – osmisté výročí

    Czech Academy of Sciences Publication Activity Database

    Blahož, Josef

    2015-01-01

    Roč. 154, č. 6 (2015), s. 449-464 ISSN 0231-6625 Institutional support: RVO:68378122 Keywords : Magna Carta Libertatum * development of constitutionalism * rule of law Subject RIV: AG - Legal Sciences

  3. Marihuana in Man: Three Years Later

    Science.gov (United States)

    Hollister, Leo E.

    1971-01-01

    Reviews three years of research on the effects of marihuana in man. Previously known clinical mental and physical effects have been confirmed. Causes and mechanisms of these effects generally remain undetermined in man and animals. Social implications and long term effects require additional study, although usage appears detrimental. (JM)

  4. An information preserving method for producing full coverage CoRoT light curves

    Directory of Open Access Journals (Sweden)

    Pascual-Granado J.

    2015-01-01

    Full Text Available Invalid flux measurements, caused mainly by the South Atlantic Anomaly crossing of the CoRoT satellite, introduce aliases in the periodogram and wrong amplitudes. It has been demonstrated that replacing such invalid data with a linear interpolation is not harmless. On the other side, using power spectrum estimators for unevenly sampled time series is not only less computationally efficient but it leads to difficulties in the interpretation of the results. Therefore, even when the gaps are rather small and the duty cycle is high enough the use of gap-filling methods is a gain in frequency analysis. However, the method must preserve the information contained in the time series. In this work we give a short description of an information preserving method (MIARMA and show some results when applying it to CoRoT seismo light curves. The method is implemented as the second step of a pipeline for CoRoT data analysis.

  5. Chronic ethanol administration increases the binding of 3H Ro-15-4513 in primary cultured spinal cord neurons

    International Nuclear Information System (INIS)

    Mlatre, M.; Ticku, M.K.

    1989-01-01

    Ro 15-4513 (ethyl-8-azido-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5α], [1,4] benzodiazepine-3-carboxylate) is reported to be a selective ethanol antagonist in biochemical and behavioral studies. The effect of chronic ethanol treatment on the binding of [ 3 H]Ro 15-4513 was investigated in cultured spinal cord neurons, which are shown to possess all the elements of GABA benzodiazepine receptor complex. Chronic ethanol treatment (50 mM for 6 hr, 12 hr, 18 hr, 3 days, and 5 3 days) produced an increase in the specific binding of [ 3 H]Ro 15-4513. The increase in binding in these neurons was due to an increase in the number (B max ) of receptor sites. This effect was specific for Ro 15-4513, since identical ethanol treatment did not alter the binding of benzodiazepine antagonist [ 3 H]Ro 15-1788 or agonist [ 3 H]flunitrazepam or inverse agonist [ 3 H]methyl-β-carboline-3-carboxylate. Similar results have been reported following chronic ethanol treatment to rats. These results suggest that the Ro 15-4513 binding sites on the oligomeric GABA receptor complex are altered following chronic ethanol administration, and support the notion of a unique role of Ro 15-4513 as an ethanol antagonist

  6. Reconstruction-of-difference (RoD) imaging for cone-beam CT neuro-angiography

    Science.gov (United States)

    Wu, P.; Stayman, J. W.; Mow, M.; Zbijewski, W.; Sisniega, A.; Aygun, N.; Stevens, R.; Foos, D.; Wang, X.; Siewerdsen, J. H.

    2018-06-01

    Timely evaluation of neurovasculature via CT angiography (CTA) is critical to the detection of pathology such as ischemic stroke. Cone-beam CTA (CBCT-A) systems provide potential advantages in the timely use at the point-of-care, although challenges of a relatively slow gantry rotation speed introduce tradeoffs among image quality, data consistency and data sparsity. This work describes and evaluates a new reconstruction-of-difference (RoD) approach that is robust to such challenges. A fast digital simulation framework was developed to test the performance of the RoD over standard reference reconstruction methods such as filtered back-projection (FBP) and penalized likelihood (PL) over a broad range of imaging conditions, grouped into three scenarios to test the trade-off between data consistency, data sparsity and peak contrast. Two experiments were also conducted using a CBCT prototype and an anthropomorphic neurovascular phantom to test the simulation findings in real data. Performance was evaluated primarily in terms of normalized root mean square error (NRMSE) in comparison to truth, with reconstruction parameters chosen to optimize performance in each case to ensure fair comparison. The RoD approach reduced NRMSE in reconstructed images by up to 50%–53% compared to FBP and up to 29%–31% compared to PL for each scenario. Scan protocols well suited to the RoD approach were identified that balance tradeoffs among data consistency, sparsity and peak contrast—for example, a CBCT-A scan with 128 projections acquired in 8.5 s over a 180°  +  fan angle half-scan for a time attenuation curve with ~8.5 s time-to-peak and 600 HU peak contrast. With imaging conditions such as the simulation scenarios of fixed data sparsity (i.e. varying levels of data consistency and peak contrast), the experiments confirmed the reduction of NRMSE by 34% and 17% compared to FBP and PL, respectively. The RoD approach demonstrated superior performance in 3D angiography

  7. SOCIO-EDUCATIONAL ASPECTS OF THE WORKING MAN FORMATION.

    Directory of Open Access Journals (Sweden)

    Y. F. Zeyer

    2013-01-01

    Full Text Available The paper analyzes a new for the Russian anthropology concept of the «working man», introduced in the Urals along with the propagation of a social and political movement «For the Working Man Protection»; the semantic content of the «man» and «labor» notions being observed as well as the process and problems of the working man formation in the modern world.The author emphasizes the asymmetry of the socio-economic and vocational educational infrastructure, along with the contradictions between the labor market demands for the technical and technological profile workers and the existing educational qualification structure of vocational schools.In author's opinion, the disorganization of labor training in comprehensive school and deficiencies of vocational education hinder the process of the industrial working man formation. The professional orientation system is criticized for being unable to meet the demands of modern economy and provide the young people with the adequate concept of the working career.For overcoming the above problems affecting the working man formation, the paper recommends modernization of the labor training system in comprehensive schools, reformation of vocational training, and renovation of professional orientation system. The special emphasis is given to the continuing training of the working man

  8. Reference Man for Asians as well as for Europeans-A change in the ICRP concept of Reference Man

    International Nuclear Information System (INIS)

    Tanaka, Gi-ichiro

    1990-01-01

    ICRP Reference Man, according to the definition, is primarily for Caucasoid populations (Western Europeans and North Americans) that contribute only 13 per cent of the world population. A speculative world population dose will, assuming a uniform exposure all over the world at a level of 10 μSv, be 50 k man Sv in total. Of this, all regions of Caucasoid populations may contribute by 22 per cent maximum. Asian populations will share about 58 per cent (29 k man Sv) of the world population dose. About eighty per cents in total of the world population can be convered by scientific dose assessment, if Reference Man data for Asians are made available. Thus the importance of establishing Asian Reference Man should be evident. The important point of characteristics of Asians is that they are 'Vegetarians' as compared to Westerners, which suggests different pathways with respect to transfer of radionuclides from foods to the human body. Therefore it is required to determine accurate and suitable parameters relevant to dose assessment. Considering the above, contribution of Japan in science and technology to Asian countries with 'knowhows' accumulated may be of a most urgent matter. (author)

  9. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Liang Y

    2016-05-01

    Full Text Available Yayun Liang,1 Benford Mafuvadze,1 Johannes D Aebi,2 Salman M Hyder1 1Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA; 2Medicinal Chemistry, Roche Pharma Research and Early Development (pRED, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland Abstract: Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration; however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylaminohexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071 (RO, which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway, on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the

  10. Economic man as model man: Ideal types, idealization and caricatures

    NARCIS (Netherlands)

    Morgan, M.S.

    2006-01-01

    Economics revolves around a central character: "economic man." As historians, we are all familiar with various episodes in the history of this character, and we appreciate his ever-changing aspect even while many of our colleagues in economics think the rational economic agent of neoclassical

  11. Plantio direto de alface americana sobre plantas de cobertura dessecadas ou roçadas

    Directory of Open Access Journals (Sweden)

    Andréia Cristina Silva Hirata

    2014-06-01

    Full Text Available O objetivo deste trabalho foi avaliar o plantio direto de alface americana no verão sobre plantas de cobertura dessecadas ou roçadas em cultivos sucessivos. O trabalho foi desenvolvido no município de Álvares Machado, São Paulo, Brasil. O delineamento experimental foi em blocos ao acaso, dispostos em parcelas subdivididas, com quatro repetições. O fator da parcela principal foram dois manejos das plantas de cobertura (dessecadas com herbicida ou roçadas e as subparcelas, seis espécies de plantas de cobertura (Cajanus cajan cv. IAPAR 43, Crotalaria spectabilis, Crotalaria juncea, Mucuna pruriens, Pennisetum glaucum e vegetação natural, além da testemunha sem plantas de cobertura. O manejo roçado apresentou desempenho inferior no primeiro cultivo da alface, todavia não diferiu do manejo químico no segundo cultivo. A cobertura do solo com mucuna apresentou maior produtividade da alface no primeiro cultivo devido ao excesso de palha das demais coberturas, o qual prejudicou o estabelecimento da alface. No segundo cultivo não houve diferenças entre as coberturas. A roçagem de plantas de cobertura é uma opção viável para plantio direto de alface sem herbicidas.

  12. Planets for Man

    National Research Council Canada - National Science Library

    Dole, Stephen; Asimov, Isaac

    2007-01-01

    "Planets for Man" was written at the height of the space race, a few years before the first moon landing, when it was assumed that in the not-too-distant future human beings "will be able to travel...

  13. Genetics and Man

    Science.gov (United States)

    Carter, C. O.

    1973-01-01

    Can genetic evolution be controlled by man in a manner which does not violate a civilized, humane, and democratic ethos? The genetics of health and illhealth and of normal variation are discussed with respect to this question. (PEB)

  14. Hemodialysis Reliable Outflow (HeRO) device in end-stage dialysis access: a decision analysis model.

    Science.gov (United States)

    Dageforde, Leigh Anne; Bream, Peter R; Moore, Derek E

    2012-09-01

    The Hemodialysis Reliable Outflow (HeRO) dialysis access device is a permanent tunneled dialysis graft connected to a central venous catheter and is used in patients with end-stage dialysis access (ESDA) issues secondary to central venous stenosis. The safety and effectiveness of the HeRO device has previously been proven, but no study thus far has compared the cost of its use with tunneled dialysis catheters (TDCs) and thigh grafts in patients with ESDA. A decision analytic model was developed to simulate outcomes for patients with ESDA undergoing placement of a HeRO dialysis access device, TDC, or thigh graft. Outcomes of interest were infection, thrombosis, and ischemic events. Baseline values, ranges, and costs were determined from a systematic review of the literature. Total costs were based on 1 year of post-procedure outcomes. Sensitivity analyses were conducted to test model strength. The HeRO dialysis access device is the least costly dialysis access with an average 1-year cost of $6521. The 1-year cost for a TDC was $8477. A thigh graft accounted for $9567 in a 1-year time period. The HeRO dialysis access device is the least costly method of ESDA. The primary determinants of cost in this model are infection in TDCs and leg ischemia necessitating amputation in thigh grafts. Further study is necessary to incorporate patient preference and quality of life into the model. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508)

    International Nuclear Information System (INIS)

    Maughan, T.S.; Newman, H.F.; Bleehen, N.M.; Ward, R.; Workman, P.

    1990-01-01

    The hypoxic cell radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole) are under evaluation as single agents (Phase III) and in combination (Phase I). Ro 03-8799 produces an acute, transient central nervous system syndrome, whereas SR 2508 causes cumulative, peripheral neurotoxicity; both effects are dose-limiting. Pharmacokinetic studies have shown the importance of area under the plasma drug concentration versus time curve (AUC) in predicting the risk of peripheral neuropathy. Most patients have very similar pharmacokinetic parameters. This study reports 2/25 patients receiving 0.75 g/m2 Ro 03-8799 plus 2.0 g/m2 SR 2508 who showed significant discrepancies in drug handling. One patient exhibited a markedly elevated AUC and prolonged t1/2 beta for SR 2508 and this was associated with an unusually rapid onset of peripheral neuropathy. A second patient showed normal handling of SR 2508 but prolonged values for both t1/2 alpha and t1/2 beta for Ro 03-8799 and unusually low levels of its N-oxide metabolite. In addition a low peak Ro 03-8799 concentration combined with a very high volume of distribution was found in this patient, leading to a normal AUC value and toxicity profile. Both patients exhibited a relatively low creatinine clearance. The mechanisms which may underlie these findings are discussed, and the importance of pharmacokinetic monitoring in the use of these agents is emphasized

  16. A methodology for costing man-rem

    International Nuclear Information System (INIS)

    Bieber, C.

    1976-03-01

    An attempt is made to provide a methodology for costing man-rem in a way that can be applied to station conditions, based on 1974 Pickering G.S. data. Factors taken into account were social costs, exposure costs (dose accounting, training, dosimetry) temporary labour costs, and permanent replacement labour costs. A figure of $620/ man-rem was derived. (LL)

  17. Grounding the RPA Force: Why Machine Needs Man

    Science.gov (United States)

    2016-06-01

    AU/ACSC/2016 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY GROUNDING THE RPA FORCE: WHY MACHINE NEEDS MAN by Charles M. Washuk, Major, USAF (MBA...6 CHALLENGES OF MANNED FLIGHT...tactics will still require the presence of an operator, or “ man .” This paper focuses on the need for the Air Force to address the 18X career field and

  18. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

    Science.gov (United States)

    Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard

    2010-01-01

    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

  19. Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.

    Science.gov (United States)

    Sroka, Magdalena; Bagavant, Harini; Biswas, Indranil; Ballard, Abigail; Deshmukh, Umesh S

    2018-01-31

    The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. This study was undertaken to investigate whether immune responses against different domains of Ro52, influences salivary gland disease in mice. Female NZM2758 mice were immunised with Ro52 domains expressed as recombinant fusion proteins with maltose binding protein (MBP) [MBP-RING-B-box, MBP-CC, MBP-CC(ΔC19), MBP-B30.2/SPRY]. Sera from immunised mice were studied for IgG antibodies to Ro52 by immunoprecipitation, and to salivary gland cells by immunofluorescence. Pilocarpine-induced saliva production was measured to evaluate salivary gland function. Submandibular glands were investigated by histopathology for inflammation and by immune-histochemistry for IgG deposition. Mice immunised with different Ro52-domains had comparable reactivity to Ro52 and to salivary gland cells. However, only mice immunised with the CC domain and its C-terminal truncated version CC(ΔC19) showed a significant drop in saliva production. None of the mice developed severe salivary gland inflammation. The salivary gland hypofunction significantly correlated with increased intra-lobar IgG deposits in the submandibular salivary glands. Our data demonstrate that epitope specificity of anti-Ro52 antibodies plays a critical role in the induction of glandular dysfunction. Clearly, screening Sjögren's syndrome patients for relative levels of Ro52 domain specific antibodies will be more informative for associating anti-Ro52 with clinical measures of the disorder.

  20. E. S. R. study of free radicals formed in the irradiated DNA-Ro 7-0582 complex

    Energy Technology Data Exchange (ETDEWEB)

    Washino, K; Kuwabara, M; Yoshii, G [Hokkaido Univ., Sapporo (Japan)

    1979-01-01

    The effect of Ro 7-0582 (1-(2-hydroxy-3-methoxypropyl)-2-nitro-imidazole) on the formation of free radicals in ..gamma..-irradiated dry DNA has been investigated. Dry samples of DNA-Ro 7-0582 and DNA nucleotide-Ro 7-0582 were prepared, and e.s.r. spectra observed at 77 K immediately after gamma-irradiation. The samples were then warmed to 297 K for 30 min, and the spectra again observed at 77 K. The sensitizer brought about an increase of 30 to 40% in radical formation in DNA. The results indicated that Ro 7-0582 acts as an efficient electron scavenger on the TMP and dAMP moieties, increasing the incidence of sugar damage. Since TMP and dAMP form a complementary pair in the DNA double helix, the increase in double strand breaks induced by electron-affinic compounds seems to be responsible for the molecular mechanism of radiosensitization in living cells.

  1. Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice

    International Nuclear Information System (INIS)

    Pedersen, J.E.; Smith, M.R.; Bugden, R.D.; Peckham, M.J.

    1979-01-01

    The distribution and clearance of misonidazole (MIS=Ro-07-0582) were studied in C57 mouse tissued and in transplants of Lewis lung tumour. The half life of the drug in blood after a dose of 1mg/g i.p. was 3 h. Some tissues, such as liver, were found to have consistently low MIS levels, and this was found to be due to degradation of the drug after removal of the tissues from the host. The in vivo cytotoxicity of MIS to Lewis lung tumour cells was studied using an in-vitro colony assay. After half of the tumours had been irradiated with 10 Gy to kill most of the oxic cells, the mice received i.p. injections of MIS. To simulate the longer drug exposure of human tumour cells (due to the longer half life in man) a repeated injection regime was used in some mice. There was no significant cell kill after a single dose, but with a prolonged exposure to the drug in the multiply injected animals, cell survival was reduced to 50% of control in both the irradiated and unirradiated tumours. Since the hypoxic fraction of the unirradiated tumour is probably not more than 30%, it would appear that MIS is not selectively cytotoxic to hypoxic cells. However, MIS had a much greater cytotoxic effect upon hypoxic Lewis lung tumour cells in vitro, with very little or no effect on cells grown in air. This would support the theory that the presence of hypoxic cells is essential for the expression of MIS cytotoxicity. (author)

  2. Manned Flight Simulator (MFS)

    Data.gov (United States)

    Federal Laboratory Consortium — The Aircraft Simulation Division, home to the Manned Flight Simulator (MFS), provides real-time, high fidelity, hardware-in-the-loop flight simulation capabilities...

  3. Preliminary study on ESR dating of Hexian-Man and its fauna

    International Nuclear Information System (INIS)

    Huang Peihua; Zheng Lizhen; Quan Yucai; Liang Renyou; Xu Yunhua; Fang Yingsan; Fang Dusheng

    1995-01-01

    ESR dating results for samples of synchronous animal tooth with the skull of Hexian-Man in the lower part of the second layer show that the age of Hexian-Man is about 300(299.80) ka, corresponding to the late stage of Peiking-Man (the HIII skull of Peking-Man). The ages of Hexian-Man's Fauna are 150-300 ka, corresponding to those of the 2nd-3rd-4th layers of Peking-Man's Cave

  4. Vasodilatory effect of the stable vasoactive intestinal peptide analog RO 25-1553 in murine and rat lungs.

    Directory of Open Access Journals (Sweden)

    Jun Yin

    Full Text Available Stable analogs of vasoactive intestinal peptide (VIP have been proposed as novel line of therapy in chronic obstructive pulmonary disease (COPD based on their bronchodilatory and anti-inflammatory effects. We speculated that VIP analogs may provide additional benefits in that they exert vasodilatory properties in the lung, and tested this hypothesis in both ex vivo and in vivo models.In isolated perfused mouse lungs and in an in vivo rat model, pulmonary blood vessels were preconstricted by hypoxia and hemodynamic changes in response to systemic (ex vivo or inhaled (in vivo administration of the cyclic VIP analog RO 25-1553 were determined.In mouse lungs, RO 25-1553 reduced intrinsic vascular resistance at normoxia, and attenuated the increase in pulmonary artery pressure in response to acute hypoxia. Consistently, inhalation of RO 25-1553 (1 mg · mL(-1 for 3 min caused an extensive and sustained (> 60 min inhibition of the pulmonary arterial pressure increase in response to hypoxia in vivo that was comparable to the effects of inhaled sildenafil. This effect was not attributable to systemic cardiovascular effects of RO 25-1553, but to a lung specific reduction in pulmonary vascular resistance, while cardiac output and systemic arterial hemodynamics remained unaffected. No adverse effects of RO 25-1553 inhalation on pulmonary gas exchange, ventilation-perfusion matching, or lung fluid content were detected.Our findings demonstrate that inhaled delivery of the stable VIP analog RO 25-1553 induces a potent and sustained vasodilatory effect in the pulmonary circulation with no detectable adverse effects. Therapeutic inhalation of RO 25-1553 may provide vascular benefits in addition to its reported anti-inflammatory and bronchodilatory effects in COPD, yet caution is warranted given the overall poor results of vasodilator therapies for pulmonary hypertension secondary to COPD in a series of recent clinical trials.

  5. Emblem for the third manned Skylab mission - Skylab 4

    Science.gov (United States)

    1973-01-01

    This is the emblem for the third manned Skylab mission. It will be a mission of up to 56 days. The symbols in the patch refer to the three major areas of investigation proposed in the mission. The tree represents man's natural environment and relates directly to the Skylab mission objectives of advancing the study of Earth resources. The hydrogen atom, as the basic building block of the universe, represents man's exploration of the physical world, his application of knowledge, and his development of technology. Since the Sun is composed primarily of hydrogen, it is appropriate that the symbol refers to the solar physics mission objectives. The human silhouette represents mankind and the human capacity to direct technology with a wisdom tempered by regard for his natural environment. It also directly relates to the Skylab medical studies of man himself. The rainbow, adopted from the Biblical story of the flood, symbolizes the promise that is offered man. It embraces man and extends to t

  6. The new V8 diesel engine from MAN; Der neue V8-Dieselmotor von MAN

    Energy Technology Data Exchange (ETDEWEB)

    Oehler, Georg; Vogel, Werner; Moeller, Inge; Tuerk, Jens [MAN Nutzfahrzeuge Motorenwerk Nuernberg AG, Nuernberg (Germany); Raup, Markus [MAN Nutzfahrzeuge, Steyr (Austria)

    2008-09-15

    MAN has developed a new V8 engine for the 16-l class with an output of 500 kW and 3,000 Nm of torque for its TGX and TGS ranges of heavy trucks. To reduce NO{sub x}, MAN has applied an SCR system with AdBlue injection. This article describes the engine concept, the design of the main components, the development of vehicle-specific add-on parts and the work carried out to optimise the combustion system and exhaust aftertreatment. (orig.)

  7. What CoRoT tells us about δ Scuti stars

    Directory of Open Access Journals (Sweden)

    Michel Eric

    2017-01-01

    Full Text Available Inspired by the so appealing example of red giants, where going from a handful of stars to thousands revealed the structure of the eigenspectrum, we inspected a large homogeneous set of around 1860 δ Scuti stars observed with CoRoT. This unique data set reveals a common regular pattern which appears to be in agreement with island modes featured by theoretical non-perturbative treatments of fast rotation. The comparison of these data with models and linear stability calculations suggests that spectra can be fruitfully characterized to first order by a few parameters which might play the role of seismic indices for δ Scuti stars, as Δv and vmax do for red giants. The existence of this pattern offers an observational support for guiding further theoretical works on fast rotation. It also provides a framework for further investigation of the observational material collected by CoRoT ([1] and Kepler ([2]. Finally, it sketches out the perspective of using δ Scuti stars pulsations for ensemble asteroseismology

  8. Hvornår er man ung?

    DEFF Research Database (Denmark)

    Gundelach, Peter; Nørregård-Nielsen, Esther C.

    2002-01-01

    Hvornår er man ung, og hvornår er man voksen? Er der forskelle i befolkningens værdier i forhold til arbejde og politik, når det undersøges ud fra henholdsvis et alders- eller generationsperspektiv? Baseret på data fra den danske del af den internationale værdiundersøgelse vises at der er så store...

  9. Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216

    International Nuclear Information System (INIS)

    Sorensen, B.S.; Jensen, P.S.; Andersen, A.H.; Christiansen, K.; Alsner, J.; Thomsen, B.; Westergaard, O.

    1990-01-01

    The effect of the 2-nitroimidazole Ro 15-0216 upon the interaction between purified topoisomerase II and its DNA substrate was investigated. The cleavage reaction in the presence of this DNA-nonintercalative drug took place with the hallmarks of a regular topoisomerase II mediated cleavage reaction, including covalent linkage of the enzyme to the cleaved DNA. In the presence of Ro 15-0216, topoisomerase II mediated cleavage was extensively stimulated at major cleavage sites of which only one existed in the 4363 base pair pBR322 molecule. The sites stimulated by Ro 15-0216 shared a pronounced sequence homology, indicating that a specific nucleotide sequence is crucial for the action of this drug. The effect of Ro 15-0216 thus differs from that of the clinically important topoisomerase II targeted agents such as mAMSA, VM26, and VP16, which enhance enzyme-mediated cleavage at a multiple number of sites. In contrast to the previous described drugs, Ro 15-0216 did not exert any inhibitory effect on the enzyme's catalytic activity. This observation might be ascribed to the low stability of the cleavage complexes formed in the presence of Ro 15-0216 as compared to the stability of the ones formed in the presence of traditional topoisomerase II targeted drugs

  10. Establishment of Filipino standard man

    International Nuclear Information System (INIS)

    Natera, E.; San Jose, V.; Napenas, D.

    1984-01-01

    The initial data gathered on measurements of total body weight and weights of specific organs from autopsy cases of normal Filipinos are reported. Comparison of the above data with the Reference Man data of ICRP which was based primarily on Caucasians suggests some differences in the average weight and height of whole body and in the weights of some organs. Hence there appears to be a need for the establishment of Filipino standard man which can be used in the estimation of internal dose commitment of the Filipinos. (author)

  11. Establishment of Filipino standard man

    Energy Technology Data Exchange (ETDEWEB)

    Natera, E.; San Jose, V.; Napenas, D.

    The initial data gathered on measurements of total body weight and weights of specific organs from autopsy cases of normal Filipinos are reported. Comparison of the above data with the Reference Man data of ICRP which was based primarily on Caucasians suggests some differences in the average weight and height of whole body and in the weights of some organs. Hence there appears to be a need for the establishment of Filipino standard man which can be used in the estimation of internal dose commitment of the Filipinos.

  12. Development of silica RO membranes

    International Nuclear Information System (INIS)

    Ikeda, Ayumi; Kawamoto, Takashi; Matsuyama, Emi; Utsumi, Keisuke; Nomura, Mikihiro; Sugimoto, Masaki; Yoshikawa, Masato

    2012-01-01

    Silica based membranes have been developed by using a counter diffusion CVD method. Effects of alkyl groups in the silica precursors and deposition temperatures had investigated in order to control pore sizes of the silica membranes. In this study, this type of a silica membrane was applied for RO separation. Effects of silica sources, deposition temperatures and post treatments had been investigated. Tetramethoxysilane (TMOS), Ethyltrimethoxysilane (ETMOS) and Phenyltrimethoxysilane (PhTMOS) were used as silica precursors. A counter diffusion CVD method was carried out for 90 min at 270 - 600degC on γ-alumina capillary substrates (effective length: 50 mm, φ: 4 nm: NOK Co.). O 3 or O 2 was introduced into the inside of the substrate at the O 2 rate of 0.2 L min -1 . Ion beam irradiation was carried out for a post treatment using Os at 490 MeV for 1.0 x 10 10 ions cm -2 or 3.0 x 10 10 ions cm -2 . Single gas permeance was measured by using H 2 , N 2 and SF 6 . RO tests were employed at 3.0 or 5.4 MPa for 100 mg L -1 of feed NaCl solution. First, effects of the silica sources were investigated. The total fluxes increased by increasing N 2 permeance through the silica membrane deposited by ETMOS. The maximum NaCl rejection was 28.2% at 12.2 kg m -2 h -1 of the total flux through the membrane deposited at 270degC. N 2 permeance was 9.6 x 10 -9 mol m -2 s -1 Pa -1 . While, total fluxes through the membrane deposited by using PhTMOS were smaller than those through the ETMOS membranes. The phenyl groups for the PhTMOS membrane must be important for the hydrophobic properties through the membrane. Next, effects of ion beam irradiation were tested for the TMOS membranes. Water is difficult to permeate through the TMOS membranes due to the low N 2 permeance through the membrane (3.1 x 10 -11 mol m -2 s -1 Pa -1 ). N 2 permeance increased to 7.3 x 10 -9 mol m -2 s -1 Pa -1 by the irradiation. Irradiation amounts had little effects on N 2 permeance. However, NaCl rejections

  13. Measurements of Man-Made Spectrum Noise Floor

    Science.gov (United States)

    Enge, Per; Akos, Dennis; Do, Juyong; Simoneau, Joel B.; Pearson, L. Wilson; Seetharam, Venkatesh; Oria, A. J. (Editor)

    2004-01-01

    This report consolidates research carried out at Clemson University and Stanford University where a series of measurements were undertaken to identify the man-made radiation present in four bands used by rather different services, namely, L1 Band (1563.42 1587.42 MHz), the Unified S-Band (2025 2110 MHz), the 2.4 GHz Industrial, Scientific and Medical (ISM) Band (2400 2482.50 MHz), and the 23.6-24.0 GHz Passive Sensing Band. Results show that there were distinctive differences in the measurement data in the frequency bands, which should be expected based on the function/regulation associated with each. The GPS L1 Band had little to none terrestrial man-made sources, but the ISM 2.4 GHz Band had a large number of man-made sources regardless of the site and the time. The Unified S Band showed mixed results depending on the sites. The Passive Sensing Band does not contain appreciable man-made radiation.

  14. Novel antidepressant candidate RO-05 modulated glucocorticoid receptors activation and FKBP5 expression in chronic mild stress model in rats.

    Science.gov (United States)

    Xing, Y; Hou, J; Meng, Q; Yang, M; Kurihara, H; Tian, J

    2015-04-02

    In this study, a novel TRI (triple reuptake inhibitors) antidepressant candidate RO-05 (4-[1-[1-(benzoyloxy)cyclohexyl]-2-(dimethylamino)ethyl]-phenyl benzoate) was investigated in TST (tail suspension test), FST (forced swimming test) and CMS (chronic mild stress) model. Results showed RO-05 significantly decreased the immobility time in FST and TST at 4.5-, 9-, 18-mg/kg in rats and 9-, 18-, 36-mg/kg in mice. Chronic administration of 18-mg/kg RO-05 improved the behavioral index, anhedonia and normalized the hyperactivity of HPA (hypothalamic-pituitary-adrenal axis) of CMS rats. We further investigated the possible mechanisms of RO-05 in the CMS model. Eighteen milligrams per kilogram of RO-05 chronic administration significantly reversed the increase of mRNA and protein expression of FKBP5 in the CMS rat hippocampus, which facilitated the activation of GR- (glucocorticoid receptor) and GR-responsive gene Foxo1 expression. RO-05 also elevated the expression of BDNF (brain-derived neurotrophic factor) in CMS rat hippocampus. In summary, our results indicated that RO-05 is a promising antidepressant candidate. The possible antidepressant mechanisms of RO-05 were the modulation of FKBP5 expression, GR activation, corresponding inhibition of HPA axis hyperactivity, and the increase of BDNF expression. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  15. 46 CFR 131.920 - Level of manning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of...

  16. Efficiently Combining Water Reuse and Desalination through Forward Osmosis-Reverse Osmosis (FO-RO) Hybrids: A Critical Review.

    Science.gov (United States)

    Blandin, Gaetan; Verliefde, Arne R D; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-07-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  17. Man bhawan - new chrysanthemum cultivar induced by gamma irradiation

    International Nuclear Information System (INIS)

    Datta, S.K.

    1987-01-01

    Attempts were made to find out the biochemical difference between two gamma ray induced chrysanthemum cultivars, 'Flirt' and 'Man Bhawan' by thin layer chromatographic and spectrophotometric analysis of pigments. The analysis were done from florets extracts of original cv., 'Flirt' and mutant 'Man Bhawan' at full bloom stage and also at fading of 'Man Bhawan'. (author)

  18. The Ideal Man and Woman According to University Students

    Science.gov (United States)

    Weinstein, Lawrence; Laverghetta, Antonio V.; Peterson, Scott A.

    2009-01-01

    The present study determined if the ideal man has changed over the years and who and what the ideal woman is. We asked students at Cameron University to rate the importance of character traits that define the ideal man and woman. Subjects also provided examples of famous people exemplifying the ideal, good, average, and inferior man and woman. We…

  19. Pengaruh Kepuasan Dan Kepercayaan Terhadap Keputusan Pembelian Ulang Pada Depot Air Minum Tris Water Reverse Osmosis System (Ro)

    OpenAIRE

    Fitria, Ika

    2011-01-01

    Kind of this survey is asociative survey which watch influence of customer satisfaction and trust to re-purchase decision on Depot Air Minum Tris Water Reverse Osmosis System (RO) and test of hypothesis use Multiple Linear Regression Analysist on α=5%. This survey used SPSS 16.00 version for windows. Research population is consumers of Depot Air Minum Tris Water Reverse Osmosis System (RO). Sample was used in this survey from customers of Depot Air Minum Tris Water Reverse Osmosis System (RO)...

  20. Woman Position In Iron Man Movies

    OpenAIRE

    ANINDITHA, ANNISA

    2014-01-01

    Aninditha, Annisa. 2014. Woman Position in Iron Man movies. Study Program ofEnglish, Department of Language and Literature, Faculty of Cultural Studies,Universitas Brawijaya, Malang. Supervisor: Fariska Pujiyanti. Co Supervisor: NurulLaily Nadhifah. Keywords: Movie, Patriarchal, Iron Man. Movie is one of literary works and electronic media. Movie becomes the best strategy to communicate and deliver message about what happens in this world. The movie makers or directors can express critics, co...

  1. 2009 Navy ManTech Project Book

    Science.gov (United States)

    2009-01-01

    build a hybrid laser / GMAW system that combined deep keyhole penetration of laser welding with the high metal deposition rate of GMAW, enabling...committed to the successful outcome of the ManTech project. In addition, this close working relationship between the parties provides ManTech with a longer...the cost and time to build and repair Navy ships. The Center works closely with the Navy’s acquisition community and the shipbuilding industry to

  2. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

    International Nuclear Information System (INIS)

    Espinosa, Alexander; Oke, Vilija; Elfving, Ase; Nyberg, Filippa; Covacu, Ruxandra; Wahren-Herlenius, Marie

    2008-01-01

    Patients with the systemic autoimmune diseases Sjoegrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1. While Ro52 and UBE2D1 are cytoplasmic proteins, UBE2E1 is localized to the nucleus. Here, we investigate how domains of human Ro52 regulate its intracellular localization. By expressing fluorescently labeled Ro52 and Ro52 mutants in HeLa cells, an intact coiled-coil domain was found to be necessary for the cytoplasmic localization of Ro52. The amino acids 381-470 of the B30.2 region were essential for translocation into the nucleus. Furthermore, after exposure of HeLa cells to the inflammatory mediator nitric oxide (NO), Ro52 translocated to the nucleus. A nuclear localization of Ro52 in inflamed tissue expressing inducible NO synthetase (iNOS) from cutaneous lupus patients was observed by immunohistochemistry and verified in NO-treated cultures of patient-derived primary keratinocytes. Our results show that the localization of Ro52 is regulated by endogenous sequences, and that nuclear translocation is induced by an inflammatory mediator. This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus

  3. Human Behaviour and the Origin of Man

    Science.gov (United States)

    Raleigh, M. J.; Washburn, S. L.

    1973-01-01

    The study of origin and evolution of man gives new perspective for understanding his behavior. Physical behaviors such as walking and throwing are results of biological evolution which has not kept pace with sociocultural evolution. Irrational decisions by man in social, cultural, and political fields are results of this brain activity. (PS)

  4. RevManHAL: towards automatic text generation in systematic reviews.

    Science.gov (United States)

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  5. CaveMan Enterprise version 1.0 Software Validation and Verification.

    Energy Technology Data Exchange (ETDEWEB)

    Hart, David

    2014-10-01

    The U.S. Department of Energy Strategic Petroleum Reserve stores crude oil in caverns solution-mined in salt domes along the Gulf Coast of Louisiana and Texas. The CaveMan software program has been used since the late 1990s as one tool to analyze pressure mea- surements monitored at each cavern. The purpose of this monitoring is to catch potential cavern integrity issues as soon as possible. The CaveMan software was written in Microsoft Visual Basic, and embedded in a Microsoft Excel workbook; this method of running the CaveMan software is no longer sustainable. As such, a new version called CaveMan Enter- prise has been developed. CaveMan Enterprise version 1.0 does not have any changes to the CaveMan numerical models. CaveMan Enterprise represents, instead, a change from desktop-managed work- books to an enterprise framework, moving data management into coordinated databases and porting the numerical modeling codes into the Python programming language. This document provides a report of the code validation and verification testing.

  6. "Bionic Man" Showcases Medical Research | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: The Bionic Man Meet the Bionic Man Past Issues / Fall 2014 Table of Contents The ... medical imaging, visit www.nibib.nih.gov "Bionic Man" Showcases Medical Research The National Institute of Biomedical ...

  7. Man in the middle attacks on SSL/TLS

    OpenAIRE

    Caro Alonso-Rodríguez, Antonio Jesús

    2013-01-01

    El proyecto estudia un tipo concreto de ataque sobre el protocolo SSL/TLS llamado "Man in the middle". El projecte estudia un tipus concret d'atac sobre el protocol SSL/TLS anomenat "Man in the middle".

  8. Alternative Frameworks for the Study of Man.

    Science.gov (United States)

    Markova, Ivana

    1979-01-01

    Two frameworks for the study of man are discussed. The Cartesian model views man as a physical object. A dialectic framework, with the emphasis on the self, grew out of nineteenth century romanticism and reflects the theories of Hegel. Both models have had an effect on social psychology and the study of interpersonal communication. (BH)

  9. 46 CFR 131.420 - Manning and supervision.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be enough trained persons aboard each survival craf...

  10. Cocteau au cirque: The Poetics of Parade and "Le Numéro Barbette"

    Directory of Open Access Journals (Sweden)

    Jennifer Forrest

    2003-01-01

    Full Text Available Parade (1917 was a joint effort production with libretto by Jean Cocteau music by Erik Satie, decor, costumes, and curtain by Pablo Picasso, and choreography by Léonide Massine. It was not only Cocteau's first truly original work, but, as Pierre Gobin contends, Parade is central to an understanding of the structures that would inform all of his subsequent work. Equally central, proposes Lydia Crowson, is Cocteau's July 1926 Nouvelle Revue Française article on "Le Numéro Barbette." The essay on the transvestite striptease trapezist Barbette offers a poetics of the theater that will have changed little by the time of his last play, L'Impromptu du Palais Royal . The underlying system structuring the Coctelian poetics perceived by Gobin and Crowson is perhaps neither in Parade nor in "Le Numéro Barbette" alone, but in both as they propose a poetics of Coctelian art as illusion, and reference and actualize the semantic register of a particular signifying system: not the fairground parade , as contends Gobin and other critics, but the circus and circus culture. But while Parade and "Le Numéro Barbette" share a circus-related theme, the circus does not function merely as a metaphor. Each work in a different way appropriates and promotes rather the circus's revolutionary orientation toward space, its creation of "real" time, and its undermining of social signifying systems, in particular those pertaining to race and gender. The circus space is like that of dreams in that it permits the irresolution and co-existence of the sort of contradictions cited by Guillaume Apollinaire in the celebrated program notes for Parade , and produced by Barbette in his aerial number. This he learned from the circus. Parade and "Le Numéro Barbette" are indeed pivotal texts in the formulation of Cocteau's very twentieth-century poétique .

  11. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO Hybrids: A Critical Review

    Directory of Open Access Journals (Sweden)

    Gaetan Blandin

    2016-07-01

    Full Text Available Forward osmosis (FO is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application and water management challenges (proximity of wastewater and desalination plants, FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  12. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

    Science.gov (United States)

    Blandin, Gaetan; Verliefde, Arne R.D.; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-01-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling. PMID:27376337

  13. Removing Fe, Zn and Mn from steel making plant wastewater using RO and NF membranes

    Directory of Open Access Journals (Sweden)

    Seyed Ahmad Mirbagheri

    2016-12-01

    Full Text Available Background and purpose: Excessive amount of heavy metals in industrial wastewater is a seriously crucial issue and requires efficient methods to be introduced and dealt with. Meanwhile, steel making plants as productive units in every country release large amounts of fluid into surface and underground sources. Typically, this wastewater contains heavy metals in minor amounts, while this amount could cause severe damages to the living organisms. Materials and methods: In this study, removing iron, manganese, zinc and total dissolved solid in a typical wastewater resulted from steel making plant was considered using reverse osmosis (RO and nanofiltration (NF membranes. At first, different pH values and operating pressures were applied to the wastewater. Then, these parameters were evaluated for a wastewater only containing iron to compare the interaction of other elements in iron removal. Results: The results indicated that RO and NF membranes could successfully treat industrial wastewater containing several heavy metals with high concentrations of Fe, Zn and Mn, especially at optimum pH and pressure. Moreover, the interaction of other heavy metals and components in the influent decreased the efficiency of RO but improved the NF efficiency to remove iron. To have a better image, a formula was proposed for each method to represent the influence of the parameters on removal rates. Finally, cost estimation for both procedures showed that RO was not economically-technically efficient in comparison with NF. Conclusion: NF showed an acceptable performance with high water flow which made it more suitable for industries. At the end, the relative cost analysis showed that even if the initial price of NF is high, the energy consumption and total cost of RO will be higher.

  14. Man and technology in the future

    International Nuclear Information System (INIS)

    1993-01-01

    The Royal Swedish Academy of Engineering Sciences has set up a committee known as The Committee of Man, Technology and Society. The members of this committee form an interdisciplinary group for the study of the interaction between scientific and technological advances and the way in which society evolves. Most of the committees activities have focused on the present relationship between man, technology and society. Attempts have been made to assess the future influence on society of key developments in biotechnology, electronic communication and systems analysis. In order to pursue this path still further, the committee decided to arrange an international symposium on the topic Man and Technology in the Future at the village of Forsmark on the Baltic coast of Sweden. The proceedings consists of 13 lectures centered on energy systems - and the connected waste problems, biotechnology, and telecommunications. Separate abstracts were prepared for 5 of the lectures in this volume

  15. Framework for man-machine interface design evaluation system considering cognitive factor

    International Nuclear Information System (INIS)

    Itoh, Toru; Sasaki, Kazunori; Yoshikawa, Hidekazu; Takahashi, Makoto; Furuta, Tomihiko.

    1994-01-01

    It is necessary to improve human reliability in order to gain a higher reliability of the total plant system taking an account of development of plant automation and improvement of machine reliability. Therefore, the role of the man-machine system will come to be important. Accordingly, the evaluation of the man-machine system design information is desired in order to solve the mismatch problem between plant information presented by the man-machine system and information required by the operator comprehensively. This paper discusses required functions and software framework for the man-machine interface design evaluation system. The man-machine interface design evaluation system has features to extract the potential matters which are inherent on the design information of man-machine system by simulating the operator behavior, the plant system and the man-machine system, considering the operator's cognitive performance and time dependency. (author)

  16. Alterations in in-vivo benzodiazepine-receptor binding of C-11-Ro15-1788 (flumazepil)

    International Nuclear Information System (INIS)

    Yamasaki, T.; Inoue, O.; Shinoto, H.; Ito, T.; Hashimoto, K.; Suzuki, K.; Tateno, Y.

    1985-01-01

    Alterations of the central benzodiazepine - receptor function caused by the change of physiological or psychological conditions, were recognized in both animal and human studies. Before the human study, animal experiments using tritiated Ro15-1788 were carried out. The stress was produced by forcing the mice to swim in a water-basin at 16 0 C for 5 min. Within 3 min after the forced swimming, the tracer was injected. Brain radioactivities in stress-loaded mice increased over a period of 15 min after the intra-venous injection of tracers, while brain activities of carrier-added tracer decreased. In human study, approximately 5 mCi of C-11-Ro15-1788, which specific activity is 0.3-1.0 Ci/μmol, were intravenously injected to each case. Measurements of the brain activity were performed using positron-CT, with blood sample collection. 31 human studies were performed on. Cerebral cortex time activity curves in several volunteers in nervous and stressful state, showed the same pattern to that in the stress-loaded animal experiment. It is important that the significant different time course of cerebral activity after the injection of labelled Ro15-1788, was observed in stressful state, compared with control, in both human and animal study. From these results, it will be concluded the positron CT study using /sup 11/C-Ro15-1788 will become a new technic to detect the change of psychological conditions in human brain and to diagnose some kind of neuropsychiatric disease

  17. Solvents in membrane synthesis and their effect on NF/RO performance: from conventional organic solvents to ionic liquids:Solventen in membraansynthese en hun effect op NF/RO performantie: van conventionele organische solventen naar ionische vloeistoffen

    OpenAIRE

    Mariën, Hanne

    2017-01-01

    Membrane technology has grown significantly over the last decades and is used in a broad range of applications nowadays. Nanofiltration (NF) and reverse osmosis (RO) are applied for the separation of low molecular weight components (< 1000 Da) and salts from the feed stream. The main part of the commercial NF and RO membranes are either integrally skinned asymmetric (ISA) or interfacially polymerized thin film composite (TFC) membranes. Polyamide (PA) TFC membranes are the standard in aqueous...

  18. A MCDM Analysis of the Roşia Montană Gold Mining Project

    Directory of Open Access Journals (Sweden)

    Adriana Mihai

    2015-06-01

    Full Text Available The need and estimated utility for a structured analysis of the Roşia Montană gold exploitation project have been palpable in the Romanian public sphere during the last 15 years and there is a vast amount of conflicting information and opinions on the benefits and risks involved. This article provides a comprehensive decision analysis of the Roşia Montană project. Over 100 documents from the past years have been gathered regarding the Roşia Montană mining project, which cover the main official, formal and less formal documents covering the case and produced by a wide range of stakeholders. These were then analyzed while designing a multi-criteria tree including the relevant perspectives under which the most commonly discussed four alternatives were analyzed. The result of this can be translated into a valuable recommendation for the mining company and for the political decision-makers. If these stakeholders want the continuation of the project and its acceptance by civil society, the key challenge is to increase the transparency of the process and improve the credibility and legal aspects; if these aspects cannot be met, the decision-makers need to pay attention to the alternatives available for a sustainable development in the area.

  19. 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.

    Directory of Open Access Journals (Sweden)

    Latisha D Heinlen

    2010-03-01

    Full Text Available Systemic lupus erythematosus (SLE is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%. However, in 34 SLE patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single autoantigen, most commonly 60 kD Ro (29%, nRNP A (24%, anti-phospholipids (18% or rheumatoid factor (15%. We identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70 K in 96% of the patients who had both autoantibodies at diagnosis. Anti-60 kD Ro antibodies appeared before or simultaneously with anti-La (98% or anti-52 kD Ro (95%. The autoantibody response in SLE patients begins simply, often binding a single specific autoantigen years before disease onset, followed by epitope spreading to additional autoantigenic specificities that are accrued in recurring patterns.

  20. MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-15

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.

  1. MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

    International Nuclear Information System (INIS)

    2016-01-01

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity

  2. Man machine interface and its implementation

    International Nuclear Information System (INIS)

    Hills, B.G.; Boettcher, D.B.; Reed, R.

    1992-01-01

    Sizewell B is the latest nuclear power station to be constructed in the United Kingdom: its Man-Machine Interfaces are therefore, by definition, the state-of-the-art. This paper discusses the principal Man-Machine Interfaces used in the operation of the station, and the systems that implement them. The Man-Machine Interface facilities discussed are: in the Main Control Room, which is used for normal operation and shutdown of the plant: in the Auxiliary Shutdown Room, which allows shutdown of the reactor if evacuation of the main Control Room is necessary: and in the Technical Support Centre, which is used for remote monitoring of the plant. The Man-Machine Interfaces that are described are parts of a station-wide group of interlinked computer systems called the Data Processing and Control System. This system collects data from the plant and displays it to the operators via discrete devices and on graphical computer displays. It also acquires control inputs from the operators via switches, which are then used to provide remote manual control, modulating control and sequence control. The computer system that handles the plant process data and alarm information displays uses a windowing interface with keyboard and trackerball navigation to allow easy retrieval and viewing of information. It is this system that is the main topic of this paper. (author)

  3. Igbo man's Belief in Prayer for the Betterment of Life | Okodo ...

    African Journals Online (AJOL)

    The Igbo man believes in Chukwu strongly. The Igbo man expects all he needs for the betterment of his life from Chukwu. He worships Chukwu traditionally. His religion, the African Traditional Religion, was existing before the white man came to the Igbo land of Nigeria with his Christianity. The Igbo man believes that he ...

  4. Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

    LENUS (Irish Health Repository)

    Higgs, Rowan

    2010-01-01

    Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren\\'s syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3\\/4 stimulation. We now present evidence that Ro52 has a similar role in regulating the stability and activity of IRF7. Endogenous immunoprecipitation of Ro52-bound proteins revealed that IRF7 associates with Ro52, an effect which increases following TLR7 and TLR9 stimulation, suggesting that Ro52 interacts with IRF7 post-pathogen recognition. Furthermore, we show that Ro52 ubiquitinates IRF7 in a dose-dependent manner, resulting in a decrease in total IRF7 expression and a subsequent decrease in IFN-alpha production. IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As Ro52 is known to be IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

  5. Rekordhind Man Ray eest

    Index Scriptorium Estoniae

    1998-01-01

    Ameerika sürrealistliku fotograafi Man Ray 1926. a. Pariisis pildistatud foto 'Must ja valge, Pariis (positiiv ja negatiiv)', mis kujutab Ray armukese Kiki de Montparnasse'i portreed, maksis New Yorgi fotooksjonil 7, 3 miljonit Eesti krooni

  6. [The life of Dr. RO Kishun, a reflection of modern Korean medical history of the borders].

    Science.gov (United States)

    Shin, Young-Jeon; Park, Se-Hong

    2009-06-01

    RO Kishun was born on February 2, 1893 in Ongjin County, Hwanghae Province of Joseon Korea. He graduated from the Medical Training Center, a campus associated with the Joseon Government-General Hospital, in 1915, and from Kyushu Imperial University School of Medicine in 1917. He continued his medical study at the university in 1929, majoring in biochemistry, and earned a doctorate in medicine in 1932. Dr. RO, one of the earliest pioneers in Korean biochemistry, was active in his research, publishing four studies in the Japanese Journal of Biochemistry between 1931 and 1932. After returning from Japan in 1932, Dr. RO opened a medical practice in Mokpo and Busan, port cities situated on the southern tip of Korea. Later in 1936, he moved north to Manchuria (northeast China) to practice medicine at the International Hospital in Mukden (present-day Shenyang). He also served as president of Tumen Public Hospital between 1942 and 1946. When Japan signed unconditional surrender bringing World War II to an end, Dr. RO relocated to Yanbian and began providing medical training to ethnic Koreans. In October 1946, he was appointed dean of the First Branch School of China Medical University in Longjing, and in October 1948 the first dean of Yanbian Medical School, the predecessor of Yanbian University College of Medicine. Dr. RO dedicated his life to medical practice, teaching and training students, and mentoring younger faculty. A brilliant clinician, he also inspired and helped his colleagues with his outstanding ability to diagnose and treat patients. He was one of the founding members of Yanbian University College of Medicine. RO Kishun died on June 7, 1957 at age 64. Ethnic Koreans hailed him as Sinui (literally, the physician of God), and a bronze statue of himself was erected in front of the medical college in 1988. Dr. RO's life brings modern historians' attention to the issue of determining geographical territories and nationality, in that his life unfolded at the

  7. A floating desalination/co-generation system using the KLT-40 reactor and Canadian RO desalination technology

    International Nuclear Information System (INIS)

    Humphries, J.R.; Davies, K.

    2000-01-01

    As the global consumption of water increases with growing populations and rising levels of industrialization, major new sources of potable water production must be developed. To address this issue efficiently and economically, a new approach has been developed in Canada for the integration of reverse osmosis (RO) desalination systems with nuclear reactors as an energy source. The resulting nuclear desalination/cogeneration plant makes use of waste heat from the electrical generation process to preheat the RO feedwater, advanced feedwater pre-treatment and sophisticated system design integration and optimization techniques. These innovations have led to improved water production efficiency, lower water production costs and reduced environmental impact. The Russian Federation is developing the KLT-40 reactor for application as a Floating Power Unit (FPU). The reactor is ideally suited for such purposes, having bad many years of successful operation as a marine propulsion reactor aboard floating nuclear powered icebreakers and other nuclear propelled vessels. Under the terms of a cooperation agreement with the Russian Federation Ministry of Atomic Energy, CANDESAL Enterprises Ltd has evaluated the FPU, containing two KLT-40 reactors, as a source of electrical energy and waste heat for RO desalination. A design concept for a floating nuclear desalination complex consisting of the FPU and a barge mounted RO desalination unit has been analyzed to establish preliminary performance characteristics for the complex. The FPU, operating as a barge mounted electrical generating station, provides electricity to the desalination barge. In addition, the condenser cooling water from the FPU is used as a source of preheated feedwater for the RO system on the desalination barge. The waste heat produced by the electrical generating process is sufficient to provide RO feedwater at a temperature of about 10 deg. C above ambient seawater temperature. Preliminary design studies have

  8. Dose-to-man studies

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    Dose-to-Man Studies focused on developing computer data handling and computer modules which permit easy, rapid assessment of the dose to southeastern United States populations from routine or accidental releases of radionuclides to atmospheric and stream systems

  9. A strategy for man-machine system development in process industries

    International Nuclear Information System (INIS)

    Wirstad, J.

    1986-12-01

    A framework for Man-Machine System design in process industry projects is reported. It is based in the Guidelines for the Design of Man-Machine interfaces which have been generated in cooperation within the European Workshop for Industrial Computer Systems (EWICS). The application of EWICS Guidelines in industrial projects is demonstrated by six User Scenarios, which represent typical projects from different industries, e.g. electrical power generation and distribution, water control, pulp and paper production, oil and gas production. In all these projects Man-Machine System design has been conducted. It is recommended in the report that each Company develops its set of Man-Machine Systems Standard techniques/procedures. At present there are several techniques/procedures available which, for moderate costs, can be adapted to specific Company conditions. A menu of such Man-Machine System techniques/procedures is presented. Means of estimating the costs and benefits of Man-Machine System design are also described. (author)

  10. 13th International Conference on Man-Machine-Environment System Engineering

    CERN Document Server

    Dhillon, Balbir

    2014-01-01

    The integrated and advanced science research topic Man-Machine-Environment System Engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science and technology in China!”   MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, “man” refers to people in the workplace (e.g. operators, decision-makers); “ machine” is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and “environment” describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of Man-Machine-Environment system...

  11. 14th International Conference on Man-Machine-Environment System Engineering

    CERN Document Server

    Dhillon, Balbir

    2015-01-01

    The integrated and advanced science research topic man-machine-environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science and technology in China!”   MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, “man” refers to people in the workplace (e.g. operators, decision-makers); “ machine” is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and “environment” describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of man-machine-environment system...

  12. Numerical simulation of turbulent flows past the RoBin helicopter with a four-bladed rotor

    Energy Technology Data Exchange (ETDEWEB)

    Xu, H.; Mamou, M.; Khalid, M. [National Research Council, Inst. for Aerospace Research, Ottawa, Ontario (Canada)]. E-mail: Hongyi.Xu@nrc.ca

    2003-07-01

    The current paper presents a turbulent flow simulation study past a generic helicopter RoBin with a four-bladed rotor using the Chimera moving grid approach. The aerodynamic performance of the rotor blades and their interactions with the RoBin fuselage are investigated using the k - {omega} SST turbulence model contained in the WIND code. The rotor is configured as a Chimera moving grid in a quasisteady flow field. The rotor blades are rectangular, untapered, linearly twisted and are made from NACA 0012 airfoil profile. The blade motion (rotation and cyclic pitching) schedule is specified in the NASA wind tunnel testing of a generic helicopter RoBin. The aerodynamic radial load distributions in the rotor plane are generated by integrating the pressure on each blade surfaces along the blade chordwise direction. The rotor flow interacts strongly with the flow coming off from the fuselage and thus has a significant impact on helicopter aerodynamic performance. (author)

  13. Study on treating of low-level radioactive reactor wastewater by combined membrane process (UF-RO)

    International Nuclear Information System (INIS)

    Lu Yunyun; Cao Qiru; Chen Yunming; Huang Lijuan; Bai Xiaofeng; Li Bing; Feng Liang

    2013-01-01

    According to the characteristics of radionuclide exists in the low-level radioactive reactor waste water from HFETR, we use a new combined membrane process separation technology to study the efficient treating of low-lever radioactive reactor wastewater. First, the prepared the simulated wastewater contained Cs + , Sr 2+ , CO 2+ , Ni 2+ , and Fe 3+ . Then, we sequentially investigated the pressure, ion concentration, pH value and EDTA, which have effects on the desalination rate of membrane processing metal ions in wastewater. The results show that: in the condition of pH = 7, and added 0.15 mol/L EDTA, the simulated wastewater separated by UF-RO, desalination rates of Cs + , Sr 2+ , CO 2+ , Ni 2+ and Fe 3+ are all above 95%; In the subsequent trials, adding 0.15 mol/L EDTA into the radioactive residuary solution, and then treating by UF-RO-RO, the decontamination efficiency can reach 95.7%. (authors)

  14. Man-machine interface for the MFTF

    International Nuclear Information System (INIS)

    Speckert, G.C.

    1979-01-01

    In any complex system, the interesting problems occur at the interface of dissimilar subsystems. Control of the Mirror Fusion Test Facility (MFTF) begins with the US Congress, which controls the dollars, which control the people, who control the nine top-level minicomputers, which control the 65 microprocessors, which control the hardware that controls the physics experiment. There are many interesting boundaries across which control must pass, and the one that this paper addresses is the man-machine one. For the MFTF, the man-machine interface consists of a system of seven control consoles, each allowing one operator to communicate with one minicomputer. These consoles are arranged in a hierarchical manner, and both hardware and software were designed in a top-down fashion. This paper describes the requirements and the design of the console system as a whole, as well as the design and operation of the hardware and software of each console, and examines the possible form of a future man-machine interface

  15. Man-machine interface for the MFTF

    Energy Technology Data Exchange (ETDEWEB)

    Speckert, G.C.

    1979-11-09

    In any complex system, the interesting problems occur at the interface of dissimilar subsystems. Control of the Mirror Fusion Test Facility (MFTF) begins with the US Congress, which controls the dollars, which control the people, who control the nine top-level minicomputers, which control the 65 microprocessors, which control the hardware that controls the physics experiment. There are many interesting boundaries across which control must pass, and the one that this paper addresses is the man-machine one. For the MFTF, the man-machine interface consists of a system of seven control consoles, each allowing one operator to communicate with one minicomputer. These consoles are arranged in a hierarchical manner, and both hardware and software were designed in a top-down fashion. This paper describes the requirements and the design of the console system as a whole, as well as the design and operation of the hardware and software of each console, and examines the possible form of a future man-machine interface.

  16. Man-machine interfaces analysis system based on computer simulation

    International Nuclear Information System (INIS)

    Chen Xiaoming; Gao Zuying; Zhou Zhiwei; Zhao Bingquan

    2004-01-01

    The paper depicts a software assessment system, Dynamic Interaction Analysis Support (DIAS), based on computer simulation technology for man-machine interfaces (MMI) of a control room. It employs a computer to simulate the operation procedures of operations on man-machine interfaces in a control room, provides quantified assessment, and at the same time carries out analysis on operational error rate of operators by means of techniques for human error rate prediction. The problems of placing man-machine interfaces in a control room and of arranging instruments can be detected from simulation results. DIAS system can provide good technical supports to the design and improvement of man-machine interfaces of the main control room of a nuclear power plant

  17. A new approach for determination of fouling potential by colloidal nanoparticles during reverse osmosis (RO) membrane filtration of seawater

    International Nuclear Information System (INIS)

    Park, Ji Yeon; Lim, Sungil; Park, Kihong

    2013-01-01

    A direct measurement of number concentration of colloidal nanoparticles (15–450 nm) in water was made with the membrane filtration-differential mobility analyzer technique, and its corresponding flux decline rate (FDR) was determined by laboratory-scale RO fouling test unit using varying number concentrations of silica nanoparticles in artificial seawaters. This relationship was used to predict fouling potential of colloidal nanoparticles in reverse osmosis (RO) membrane process of seawaters in RO plant. It was found that the FDR linearly increased with the increasing number of colloidal nanoparticles for the given concentration range and that the relationship between the number concentration and the FDR also depended on RO membrane surface properties. Data for estimated FDR values for natural seawaters after pretreatment showed a clear difference among samples, which is contrary to the pre-existing index such as silt density index and modified fouling index. Our data suggest that measurement of colloidal nanoparticles is useful for selection of proper pretreatment and successful operation of RO membrane process along with other particle fouling predictors accounting for large particles (>450 nm).

  18. A new approach for determination of fouling potential by colloidal nanoparticles during reverse osmosis (RO) membrane filtration of seawater

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ji Yeon; Lim, Sungil; Park, Kihong, E-mail: kpark@gist.ac.kr [Gwangju Institute of Science and Technology (GIST), School of Environmental Science and Engineering (Korea, Republic of)

    2013-04-15

    A direct measurement of number concentration of colloidal nanoparticles (15-450 nm) in water was made with the membrane filtration-differential mobility analyzer technique, and its corresponding flux decline rate (FDR) was determined by laboratory-scale RO fouling test unit using varying number concentrations of silica nanoparticles in artificial seawaters. This relationship was used to predict fouling potential of colloidal nanoparticles in reverse osmosis (RO) membrane process of seawaters in RO plant. It was found that the FDR linearly increased with the increasing number of colloidal nanoparticles for the given concentration range and that the relationship between the number concentration and the FDR also depended on RO membrane surface properties. Data for estimated FDR values for natural seawaters after pretreatment showed a clear difference among samples, which is contrary to the pre-existing index such as silt density index and modified fouling index. Our data suggest that measurement of colloidal nanoparticles is useful for selection of proper pretreatment and successful operation of RO membrane process along with other particle fouling predictors accounting for large particles (>450 nm).

  19. IMPLEMENTASI MANAJEMEN PERUBAHAN DI MAN 3 PALEMBANG SUMATERA SELATAN

    Directory of Open Access Journals (Sweden)

    Afriantoni Imran

    2014-11-01

    Full Text Available AbstractMadrasah Aliyah Negeri (MAN 3 Palembang is unique enough to be studied because since inception of Islamic religion teacher education institutions. The results of this study found that type of leadership visoner is owned by head of Man 3 Palembang oriented management of change and continues over time. Visionary leadership is the key. Head of MAN 3 Palembang has been able to create, formulate, communicate, socialize, transform, and implement the ideal thoughts coming from him and the result of social interaction between members of organization and stakeholders that are believed to achieve ideals of organization in the future. In addition, management of change has been initiated through an internal analysis of the organization by identifying four areas, namely services, finance, human resources and facilities in order to discover the strengths and weaknesses internal to the organization. All of this has been the commitment of all personnel MAN 3 Palembang to achieve my goals and success. Lastly, head of MAN 3 Palembang has been able to implement management changes, so that the organization built quality improvement-oriented leadership, teacher quality, school programs, students' final exam results, student achievement and strong school culture. Keywords: implementation, management of change, MAN 3 Palembang

  20. Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells.

    OpenAIRE

    Maruyama, K; Kodama, I; Anno, T; Suzuki, R; Toyama, J

    1995-01-01

    1. Cardiac effects of Ro 22-9194 were examined in papillary muscles and single ventricular myocytes isolated from guinea-pigs and compared with those of moricizine. 2. In papillary muscles, both Ro 22-9194 (> or = 10 microM) and moricizine (> or = 1 microM) caused a significant dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of the action potential duration. 3. In the presence of either drug, trains of stimuli at rates > or = 0.2 Hz led to an exponential decli...

  1. A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited.

    Science.gov (United States)

    Bridwell-Rabb, Jennifer; Grell, Tsehai A J; Drennan, Catherine L

    2018-06-20

    S-adenosylmethionine (AdoMet) has been referred to as both "a poor man's adenosylcobalamin (AdoCbl)" and "a rich man's AdoCbl," but today, with the ever-increasing number of functions attributed to each cofactor, both appear equally rich and surprising. The recent characterization of an organometallic species in an AdoMet radical enzyme suggests that the line that differentiates them in nature will be constantly challenged. Here, we compare and contrast AdoMet and cobalamin (Cbl) and consider why Cbl-dependent AdoMet radical enzymes require two cofactors that are so similar in their reactivity. We further carry out structural comparisons employing the recently determined crystal structure of oxetanocin-A biosynthetic enzyme OxsB, the first three-dimensional structural data on a Cbl-dependent AdoMet radical enzyme. We find that the structural motifs responsible for housing the AdoMet radical machinery are largely conserved, whereas the motifs responsible for binding additional cofactors are much more varied.

  2. Man-machine dialogue design and challenges

    CERN Document Server

    Landragin, Frederic

    2013-01-01

    This book summarizes the main problems posed by the design of a man-machine dialogue system and offers ideas on how to continue along the path towards efficient, realistic and fluid communication between humans and machines. A culmination of ten years of research, it is based on the author's development, investigation and experimentation covering a multitude of fields, including artificial intelligence, automated language processing, man-machine interfaces and notably multimodal or multimedia interfaces. Contents Part 1. Historical and Methodological Landmarks 1. An Assessment of the Evolution

  3. RoMPS concept review automatic control of space robot, volume 2

    Science.gov (United States)

    Dobbs, M. E.

    1991-01-01

    Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form and include: (1) system concept; (2) Hitchhiker Interface Requirements; (3) robot axis control concepts; (4) Autonomous Experiment Management System; (5) Zymate Robot Controller; (6) Southwest SC-4 Computer; (7) oven control housekeeping data; and (8) power distribution.

  4. Characterization and biotoxicity assessment of dissolved organic matter in RO concentrate from a municipal wastewater reclamation reverse osmosis system.

    Science.gov (United States)

    Sun, Ying-Xue; Gao, Yue; Hu, Hong-Ying; Tang, Fang; Yang, Zhe

    2014-12-01

    Reverse osmosis (RO) concentrate from municipal wastewater reclamation reverse osmosis (mWRRO) system containing organic compounds may associate with toxic risk, and its discharge might pose an environmental risk. To identify a basis for the selection of feasible technology in treating RO concentrates, the characteristics and biotoxicity of different fractions of dissolved organic matter (DOM) in RO concentrates from an mWRRO system were investigated. The results indicated that the hydrophilic neutrals (HIN), hydrophobic acids (HOA) and hydrophobic bases (HOB) accounted for 96% of the dissolved organic carbon (DOC) of the total DOM in the RO concentrate. According to the SEC chromatograph detected at 254 nm wavelength of UV, the DOM with molecular weight (MW) 1-3 kDa accounted for the majority of the basic and neutral fractions. The fluorescence spectra of the excitation emission matrix (EEM) indicated that most aromatic proteins, humic/fulvic acid-like and soluble microbial by-product-like substances existed in the fractions HOA and hydrophobic neutrals (HON). The genotoxicity and anti-estrogenic activity of the RO concentrate were 1795.6 ± 57.2 μg 4-NQOL(-1) and 2.19 ± 0.05 mg TAM L(-1), respectively. The HIN, HOA, and HOB contributed to the genotoxicity of the RO concentrate, and the HIN was with the highest genotoxic level of 1007.9 ± 94.8 μg 4-NQOL(-1). The HOA, HON, and HIN lead to the total anti-estrogenic activity of the RO concentrate, and HOA occupied approximately 60% of the total, which was 1.3 ± 0.17 mg TAM L(-1). Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Computational molecular spectroscopy of X ˜ 2 Π NCS: Electronic properties and ro-vibrationally averaged structure

    Science.gov (United States)

    Hirano, Tsuneo; Nagashima, Umpei; Jensen, Per

    2018-04-01

    For NCS in the X ˜ 2 Π electronic ground state, three-dimensional potential energy surfaces (3D PESs) have been calculated ab initio at the core-valence, full-valence MR-SDCI+Q/[aug-cc-pCVQZ (N, C, S)] level of theory. The ab initio 3D PESs are employed in second-order-perturbation-theory and DVR3D calculations to obtain various molecular constants and ro-vibrationally averaged structures. The 3D PESs show that the X ˜ 2 Π NCS has its potential minimum at a linear configuration, and hence it is a "linear molecule." The equilibrium structure has re (N-C) = 1.1778 Å, re (C-S) = 1.6335 Å, and ∠e (N-C-S) = 180°. The ro-vibrationally averaged structure, determined as expectation values over DVR3D wavefunctions, has 〈 r (N-C)〉0 = 1.1836 Å, 〈 r (C-S)〉0 = 1.6356 Å, and 〈 ∠ (N-C-S)〉0 = 172.5°. Using these expectation values as the initial guess, a bent r0 structure having an 〈 ∠ (N-C-S)〉0 of 172.2° is deduced from the experimentally reported B0 values for NC32S and NC34S. Our previous prediction that a linear molecule, in any ro-vibrational state including the ro-vibrational ground state, is to be "observed" as being bent on ro-vibrational average, has been confirmed here theoretically through the expectation value for the bond-angle deviation from linearity, 〈 ρ bar 〉 , and experimentally through the interpretation of the experimentally derived rotational-constant values.

  6. THE CoRoT DISCOVERY OF A UNIQUE TRIPLE-MODE CEPHEID IN THE GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Poretti, E. [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, I-23807 Merate (Italy); Baglin, A. [LESIA, Université Pierre et Marie Curie, Université Denis Diderot, Observatoire de Paris, F-92195 Meudon Cedex (France); Weiss, W. W., E-mail: ennio.poretti@brera.inaf.it [Institute of Astronomy, University of Vienna, Türkenschanzstrasse 17, A-1180 Vienna (Austria)

    2014-11-10

    The exploitation of the CoRoT treasure of stars observed in the exoplanetary field allowed the detection of a unusual triple-mode Cepheid in the Milky Way, CoRoT 0223989566. The two modes with the largest amplitudes and a period ratio of 0.80 are identified with the first (P {sub 1} = 1.29 days) and second (P {sub 2} = 1.03 days) radial overtones. The third period, which has the smallest amplitude but is able to produce combination terms with the other two, is the longest one (P {sub 3} = 1.89 days). The ratio of 0.68 between the first-overtone period and the third period is the unusual feature. Its identification with the fundamental radial or a nonradial mode is discussed with respect to similar cases in the Magellanic Clouds. In both cases, the period triplet and the respective ratios make the star unique in our Galaxy. The distance derived from the period-luminosity relation and the galactic coordinates put CoRoT 0223989566 in the metal-rich environment of the ''outer arm'' of the Milky Way.

  7. Man in Society

    Institute of Scientific and Technical Information of China (English)

    单祝堂

    1994-01-01

    Men usually want to have their own way.They want to thinkand act as they like.No one,however,can have his own way all thetime.A man cannot live in society without considering the interestsof others as well as his own interests.’Society’ means a groupof people with the same laws and the same way of life.People in

  8. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    Science.gov (United States)

    Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

    2015-03-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. The GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending-angle operator, and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research Community Atmosphere Model with Spectral Element dynamical core (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS local ensemble transform Kalman filter (LETKF) data assimilation system, which has been successfully implemented to a cubed-sphere model with unstructured quadrilateral meshes. As a result of data processing, the bending-angle departure statistics between observation and background show significant improvement. Also, the first experiment in assimilating GPS-RO bending angle from KPOP within KIAPS-LETKF shows encouraging results.

  9. Power system technologies for the manned Mars mission

    International Nuclear Information System (INIS)

    Bents, D.; Patterson, M.J.; Berkopec, F.; Myers, I.; Presler, A.

    1986-01-01

    The high impulse of electric propulsion makes it an attractive option for manned interplanetary missions such as a manned mission to Mars. This option is, however, dependent on the availability of high energy sources for propulsive power in addition to that required for the manned interplanetary transit vehicle. Two power system technologies are presented: nuclear and solar. The ion thruster technology for the interplanetary transit vehicle is described for a typical mission. The power management and distribution system components required for such a mission must be further developed beyond today's technology status. High voltage-high current technology advancements must be achieved. These advancements are described. In addition, large amounts of waste heat must be rejected to the space environment by the thermal management system. Advanced concepts such as the liquid droplet radiator are discussed as possible candidates for the manned Mars mission. These thermal management technologies have great potential for significant weight reductions over the more conventional systems

  10. Man and Cosmos from the Christian Theology perspective

    Directory of Open Access Journals (Sweden)

    Marin BUGIULESCU

    2017-06-01

    Full Text Available The purpose of this paper is to analyse the theological reflection on the relationship between man and cosmos. The origin of the world and man is connected to God; God is the Creator and consequently the Author of them both. Unlike dualistic materialistic thinking, according to the Christian conception the whole cosmos is created by God. In search for the cosmos an important chapter was granted for man, considered to be a synthesis of the world. Man, from the theological perspective, is the personal, rational, free, and speaking being that has – through the image of God according to which he has been created –, the tension after perfection. But it pertains exclusively to the relationship with Christ in the light of Whom he really knows himself, and by knowing himself he recognizes the infinite beauty of the Archetype. This is the existential-theological truth, which the content of this paper emphasizes, according to the Bible and patristic teaching.

  11. In-Building Wireless Distribution in legacy Multimode Fiber with an improved RoMMF system

    DEFF Research Database (Denmark)

    Visani, Davide; Petersen, Martin Nordal; Sorci, Francesca

    2012-01-01

    A radio over multimode fiber (RoMMF) system for in-building wireless distribution employing a directly modulated Fabry-Perot (FP) transmitter and the central launch technique is presented. The worst-case spurious free dynamic range (SFDR) exceeds 105 dB×Hz2/3 up to 525 m of OM2 multimode fiber (MMF......). Experimental and theoretical results are reported showing that this scheme outperforms a RoMMF system employing a distributed feed-back (DFB) laser diode (LD) and/or a mode scrambler to achieve overfilled launch (OFL). Long Term Evolution (LTE) signal transmission is achieved with high quality in terms...... of Adjacent Channel Leakage Ratio (ACLR) and Error Vector Magnitude (EVM)....

  12. The half-yellow man

    African Journals Online (AJOL)

    The half-yellow man. BJ Merwitza* and FJ Raala. aFaculty of Health Sciences, Carbohydrate and Lipid Metabolism Research Unit, University of the Witswaterand, Johannesburg, South Africa. *Corresponding author, emails: bmerwitz@hotmail.com, brad.merwitz@gmail.com. Keywords: diffuse normolipaemic planar ...

  13. 10 CFR 72.94 - Design basis external man-induced events.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

  14. Photonic microwave carrier recovery using period-one nonlinear dynamics of semiconductor lasers for OFDM-RoF coherent detection.

    Science.gov (United States)

    Hung, Yu-Han; Yan, Jhih-Heng; Feng, Kai-Ming; Hwang, Sheng-Kwang

    2017-06-15

    This study investigates an all-optical scheme based on period-one (P1) nonlinear dynamics of semiconductor lasers, which regenerates the microwave carrier of an orthogonal frequency division multiplexing radio-over-fiber (OFDM-RoF) signal and uses it as a microwave local oscillator for coherent detection. Through the injection locking established between the OFDM-RoF signal and the P1 dynamics, frequency synchronization with highly preserved phase quality is inherently achieved between the recovered microwave carrier and the microwave carrier of the OFDM-RoF signal. A bit-error ratio down to 1.9×10-9 is achieved accordingly using the proposed scheme for coherent detection of a 32-GHz OFDM-RoF signal carrying 4  Gb/s 16-quadrature amplitude modulation data. No electronic microwave generators or electronic phase-locked loops are thus required. The proposed system can be operated up to at least 100 GHz and can be self-adapted to certain changes in the operating microwave frequency.

  15. Optimization of AMI-MDM-RoFSO under atmospheric turbulence

    Directory of Open Access Journals (Sweden)

    Chaudhary Sushank

    2017-01-01

    Full Text Available Radio over Free Space (Ro-FSO is promising candidate for providing ubiquitous digital services especially in rural areas. This work investigates the performance of MDM of two 5Gbps-10GHz data channels over FSO link using LP 01 and LP 02 modes under the effect of atmospheric turbulences. The signal to noise ratio (SNR, total received power, modal decomposition at receiver at the receiver is also reported. The reported result shows the successful transmission of two channels with acceptable SNR over FSO link under atmospheric turbulences.

  16. Sådan bygger man en kvantecomputer

    DEFF Research Database (Denmark)

    Mølmer, Klaus

    2009-01-01

    KRONIK: Professor Klaus Mølmer forklarer, hvordan man kan konstruere en kvantecomputer. Det kræver en brudebuket, der både er der og ikke er der, og som kan kastes til alle gæsterne ved et bryllup på samme tid.......KRONIK: Professor Klaus Mølmer forklarer, hvordan man kan konstruere en kvantecomputer. Det kræver en brudebuket, der både er der og ikke er der, og som kan kastes til alle gæsterne ved et bryllup på samme tid....

  17. Innovative MAN Euro V engines without exhaust aftertreatment; Innovative MAN Euro V Motorisierung ohne Abgasnachbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Held, W.; Raab, G.; Schaller, K.V.; Gotre, W.; Lehmann, H.; Moeller, H.; Schroeppel, W. [MAN Nutzfahrzeuge AG, Muenchen (Germany); MAN Nutzfahrzeuge AG, Nuernberg (Germany); MAN Nutzfahrzeuge AG, Steyr (Austria)

    2009-07-01

    MAN Nutzfahrzeuge AG (Munich, Federal Republic of Germany) always is eager to offer products for the respective markets whereby the products are interesting for the customer under economic criteria. Additionally, the products shall not lack in the travelling comfort under consideration of the legal emission borders. Thus, a AdBlue {sup registered} free technology for all MAN series was already offered before the legal introduction of EURO IV. This technology is based on an internal-motor solution with external, cooled AGR and a PM-Cat {sup registered} -filter. This solution is esteemed highly by our customers because apart from the well-known advantages in relation to a SCR technology there were no losses with the operating cost. With EURO V which is inserted in some countries MAN Nutzfahrzeuge AG returns to a long-term experience with SCR technology. The motivation for the development of a AdBlue {sup registered} free solution was the positive feedback of our customers on the basis of MAN EURO IV AGR/PM Cat technology. With the developed EURO V AGR solution, other EURO IV solutions in line with market conditions for the 'Emerging markets' can be derived with which a technology without exhaust post-treatment can be offered worldwide for our customers. This technology presents the basis for a platform concept EURO IV/V and EURO VI. In this concept, EURO IV can be presented without subsequent treatment of exhaust gases, EURO V in connection with an Oxicat and EURO VI with a SCRT system. Here, the vehicle/engine concept presents the most important components for the individual series in particular. By means of these components, the goal EURO V was achieved internal-motor without losses of operating cost and life span in relation to SCR technologies.

  18. Life Cycle Assessment of man-made cellulose fibres

    NARCIS (Netherlands)

    Shen, L.; Patel, M.K.

    2010-01-01

    The production of textile materials has undergone dramatic changes in the last century. Man-made cellulose fibres have played an important role for more than 70 years. Today, the man-made cellulose fibre industry is the worldwide second largest biorefinery (next to the paper industry). In the last

  19. Piinatud birmalased ootavad ÜRO seni jõuetut abikätt / Karin Dean

    Index Scriptorium Estoniae

    Dean, Karin

    2007-01-01

    Buda munkade eestvedmisel toimunud massimeeleavalduste mahasurumisest Birmas. ÜRO erisaadiku Ibrahim Gambari kohtumisest nii Birma kindralite kui ka opositsiooniliidri Aung San Suu Kyiga oodatakse tulemusi ja sanktsioone Lisa: Sõjaväe haardes riik

  20. The Modern Igbo Man and Quest for Freedom | Ogugua | AFRREV ...

    African Journals Online (AJOL)

    The modern Igbo man has through the decades been beset with one type of problem or the other. He has known multi-quam problems: poverty, ignorance, marginalization, genocide, betrayal, war etc. It is the onus of this paper to examine our operative concepts, Igbo man.s set of unfreedoms, and the shades of Igboman.s ...

  1. Evaluation of TEG(®) and RoTEM(®) inter-changeability in trauma patients.

    Science.gov (United States)

    Hagemo, Jostein S; Næss, Paal A; Johansson, Pär; Windeløv, Nis A; Cohen, Mitchell Jay; Røislien, Jo; Brohi, Karim; Heier, Hans Erik; Hestnes, Morten; Gaarder, Christine

    2013-05-01

    Massive haemorrhage is a leading cause of preventable deaths in trauma. Traumatic coagulopathy is frequently present early after trauma, and is associated with increased mortality. A number of recent trials suggest that viscoelastic haemostatic assays (VHA), such as thromboelastography and thromboelastometry, are useful tools in guiding transfusion. Treatment algorithms exist for the use of VHAs but are not validated in traumatic haemorrhage. In this study we examined the inter-changeability of two commonly used VHAs, TEG(®) and RoTEM(®). A total of 184 trauma patients over the age of 18, requiring full trauma team activation, were included at three different hospitals in three different countries (Copenhagen, Denmark, San Francisco, CA, USA and Oslo, Norway). Blood samples were drawn immediately upon arrival, and TEG(®) and RoTEM(®) analyzed simultaneously. Correlations were calculated using. Spearman's rank correlation coefficient. Agreement was evaluated by Bland-Altman plots and calculation of limits of agreement. The mean ISS in the total population was 17, and the mortality was 16.5%. Mean base excess was -2.8 (SD: 4.2). The correlation coefficient for corresponding values for the two devices was 0.24 for the R-time vs CT in all centres combined. For the K-time vs CFT the correlation was 0.48, for the α-angleTEG vs α-angleRoTEM 0.44, and for MA vs MCF 0.76. Limits of agreement exceeded the preset clinically acceptable deviation of 10% for all variables in all centres except for MA/MCF in one centre (Copenhagen). Generally, correlation coefficients were lower and agreement poorer in the one centre (Oslo) where measurements were performed bedside by clinicians. Inter-changeability between TEG(®) and RoTEM(®) is limited in the trauma setting. Agreement seems poorer when clinicians operate the devices. Development and validation of separate treatment algorithms for the two devices is required. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Environmental impact assessment of man-made cellulose fibres

    NARCIS (Netherlands)

    Shen, L.; Worrell, E.; Patel, M.K.

    2010-01-01

    Man-made cellulose fibres have played an important role in the production of textile products for more than 70 years. The purpose of this study is to assess the environmental impact of man-made cellulose fibres. Life cycle assessment (LCA) was conducted for three types of fibres (i.e. Viscose, Modal

  3. Sexual Harassment and Manly Sports: Are They Related?

    Science.gov (United States)

    Murolo, Nancy Maurer; Schmelkin, Liora Pedhazur

    This study investigates the relationship between sexual harassment and participation in "manly" sports (i.e., football, baseball, basketball, soccer, and wrestling) at the high school level. Manly sports are defined as those sports that celebrate values of dominance, aggression, male solidarity, and female exclusion. Participants were 353 11th-…

  4. Evaluation of the airway of the SimMan full-scale patient simulator

    DEFF Research Database (Denmark)

    Hesselfeldt, R; Kristensen, M S; Rasmussen, L S

    2005-01-01

    SimMan is a full-scale patient simulator, capable of simulating normal and pathological airways. The performance of SimMan has never been critically evaluated.......SimMan is a full-scale patient simulator, capable of simulating normal and pathological airways. The performance of SimMan has never been critically evaluated....

  5. A Comprehensive Study on the Application of Reverse Osmosis (RO Technology for the Petroleum Industry Wastewater Treatment

    Directory of Open Access Journals (Sweden)

    Shahryar Jafarinejad

    2017-10-01

    Full Text Available Large quantities of oily wastewaters can be generated from the activities and processes in the petroleum industry which draining of these effluents not only pollutes the environment but also reduces the yield of oil and water. Therefore, development of treatment processes for petroleum industry wastewaters is vital in order to prevent serious environmental damage and provide a source of water for beneficial use. Reverse osmosis (RO can be the most common membrane process used for desalination from oily wastewater and can produce water suitable for reuse at the petroleum industry. In this study, the application of RO technology for the petroleum industry wastewater treatment in different laboratory, pilot, field, and industrial scales have been reviewed. In addition, membrane fouling control, performance efficiency, treatment system configurations, pretreatment methods, quality of treated water, and economic issues have been investigated. With mixtures as complex as petroleum industry wastewaters, membrane fouling becomes a significant hurdle to implement the RO-based purification system. Operating the system within the critical flux range or adding chemicals, and/or pretreatment can usually control membrane fouling. Salt rejection of RO membranes can be 99% or higher.

  6. Sté výročí narození Simone de Beauvoir

    Czech Academy of Sciences Publication Activity Database

    Uhde, Zuzana

    2008-01-01

    Roč. 44, č. 4 (2008), s. 797-799 ISSN 0038-0288 R&D Projects: GA AV ČR 1QS700280503 Institutional research plan: CEZ:AV0Z70280505 Keywords : Simone de Beauvoir * Feminism Subject RIV: AO - Sociology, Demography Impact factor: 0.427, year: 2008

  7. Ab initio ro-vibronic spectroscopy of SiCCl (X{sup ~2}Π)

    Energy Technology Data Exchange (ETDEWEB)

    Brites, Vincent [Université d’Evry Val d’Essonne, Laboratoire Analyse et Modélisation pour la Biologie et l’Environnement, LAMBE CNRS UMR 8587, Boulevard F. Mitterrand, 91025 Evry Cedex (France); Mitrushchenkov, Alexander O.; Léonard, Céline, E-mail: celine.leonard@u-pem.fr [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallée (France); Peterson, Kirk A. [Department of Chemistry, Washington State University, Pullman, Washington 99164 (United States)

    2014-07-21

    The full dimensional potential energy surfaces of the {sup 2}A{sup ′} and {sup 2}A{sup ′′} electronic components of X{sup ~2}Π SiCCl have been computed using the explicitly correlated coupled cluster method, UCCSD(T)-F12b, combined with a composite approach taking into account basis set incompleteness, core-valence correlation, scalar relativity, and higher order excitations. The spin-orbit and dipole moment surfaces have also been computed ab initio. The ro-vibronic energy levels and absorption spectrum at 5 K have been determined from variational calculations. The influence of each correction on the fundamental frequencies is discussed. An assignment is proposed for bands observed in the LIF experiment of Smith et al. [J. Chem. Phys. 117, 6446 (2002)]. The overall agreement between the experimental and calculated ro-vibronic levels is better than 7 cm{sup −1} which is comparable with the 10–20 cm{sup −1} resolution of the emission spectrum.

  8. Manned underwater intervention during deep-water operations

    Energy Technology Data Exchange (ETDEWEB)

    Lothe, Mikal Sjur

    2010-07-01

    The focus for deep and remote areas operations are Remote Operated systems. Manned intervention is generally first choice when looking for intervention methods in most areas of the world. As an industry we need to focus on the most cost effective and safe method for construction, Maintenance and Repair. The focus is on advances in diving methods related to surface oriented and saturation diving, such as shallow water tie-ins of risers and umbilicals, inspection and evaluations of FPSOs including thruster change-out and wet docking. Also, the options for efficient repair scenarios utilizing man's ability to work in low visibility areas by feel etc. Finally the presentation will show new technology in Saturation Diving based on the 24 man saturation systems onboard the 3rd generation Divex systems used by Technip and Subsea 7. (Author)

  9. 42 CFR 84.103 - Man tests; performance requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests; performance requirements. 84.103 Section 84.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.103 Man tests;...

  10. Johri, Prof. Man Mohan

    Indian Academy of Sciences (India)

    Elected: 1983 Section: General Biology. Johri, Prof. Man Mohan Ph.D. (Delhi), FNA. Date of birth: 15 September 1940. Specialization: Plant Biochemistry, Molecular Biology of Plants and Genetic Engineering Address: Flat No. 32, New Cosmos CHSL, Juhu-Versova Link Road, Andheri (W), Mumbai 400 053, Maharashtra

  11. Man-Made Climatic Changes

    Science.gov (United States)

    Landsberg, Helmut E.

    1970-01-01

    Reviews environmental studies which show that national climatic fluctuations vary over a wide range. Solar radiation, earth temperatures, precipitation, atmospheric gases and suspended particulates are discussed in relation to urban and extraurban effects. Local weather modifications and attempts at climate control by man seem to have substantial…

  12. Man-machine interactions 3

    CERN Document Server

    Czachórski, Tadeusz; Kozielski, Stanisław

    2014-01-01

    Man-Machine Interaction is an interdisciplinary field of research that covers many aspects of science focused on a human and machine in conjunction.  Basic goal of the study is to improve and invent new ways of communication between users and computers, and many different subjects are involved to reach the long-term research objective of an intuitive, natural and multimodal way of interaction with machines.  The rapid evolution of the methods by which humans interact with computers is observed nowadays and new approaches allow using computing technologies to support people on the daily basis, making computers more usable and receptive to the user's needs.   This monograph is the third edition in the series and presents important ideas, current trends and innovations in  the man-machine interactions area.  The aim of this book is to introduce not only hardware and software interfacing concepts, but also to give insights into the related theoretical background. Reader is provided with a compilation of high...

  13. The future of oil and hydrocarbon man

    CERN Document Server

    Campbell, Colin

    1999-01-01

    Man appeared on the planet about four million years ago, and by 1850 numbered about one billion Ten came Hydrocarbon man. World population has since increased six-fold. After the oil price shocks of the 1970s, people asked "when will production peak?". It is not easy to answer this question because of the very poor database. Reserves and the many different hydrocarbon categories are poorly defined, reporting practices are ambiguous, revisions are not backdated...

  14. [Knowledge of Man Returns: Some Considerations on Spirituality and Resilience].

    Science.gov (United States)

    Kumakura, Nobuhiro

    2015-01-01

    Over the last decade,"spirituality" and "resilience" have jointly become a topic in psychiatry. The aim of this paper is to discuss the future of psychiatry suggested by this topic. It may be related to what Jaspers, K. called "Knowledge of Man (die Erkenntnis des Menschen)". Knowledge of man in psychiatry can be learned only through clinical experince: e. g., clinical observations and case studies. Modern academic psychiatry seems to be suffering a loss of knowledge of man, which returns periodically in clinical practice. Hence, I will call the re-discovery of the topic in psychiatry as "Return of Man". Since WW II, there have been three eras in which psychiatrists showed deep concern regarding knowledge of man. Firstly, psychopathology and psychotherapy widely developed, when the destructive impulses of mankind were revealed in the nuclear weapons of WW II. Secondly, in the 1970's, the reforms of psychiatric services and legal systems took place somewhat successfully, when social reforms were concerns of the younger generations. Lastly, over the last decade, the topic again returned as spirituality and resilience, when scientists seemed to be powerless in the aftermath of the West Japan Earthquake. Regarding the definition of health made by the WHO in 1946, I further discuss that "Return of Man" in psychiatry is the necessary dynamism between negative and positive health, or between disease control and health promotion. There is an underlying dynamism between "Knowledge of Man" and natural sciences, which is constantly changing. So long as any theory can exist only as a part of dynamism, the Return of Man may re-surface whenever clinical theories do not fit with clinical realities.

  15. Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

    International Nuclear Information System (INIS)

    Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.

    1989-01-01

    The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone

  16. 42 CFR 84.101 - Man test 5; requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.101 Man test 5; requirements....

  17. 42 CFR 84.102 - Man test 6; requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.102 Man test 6; requirements....

  18. VizieR Online Data Catalog: Spectral types of stars in CoRoT fields (Sebastian+, 2012)

    Science.gov (United States)

    Sebastian, D.; Guenther, E. W.; Schaffenroth, V.; Gandolfi, D.; Geier, S.; Heber, U.; Deleuil, M.; Moutou, C.

    2012-03-01

    Spectroscopic classification for 2950 O-, B-, and A-type stars in the CoRoT-fields IRa01, LRa01, and LRa02. Stars are named by their CoRoT-identifier and Coordinates are given. The visual magnitudes were obtained with the Wide Field Camera filter-system of the Isaac Newton Telescope at Roque de los Muchachos Observatory on La Palma and can be converted into Landolt standards, as shown in Deleuil et al. (2009AJ....138..649D). (1 data file).

  19. Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints

    Science.gov (United States)

    Nadège, Lagarde

    The availability of asteroseismic constraints for a large sample of red-giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations. We use a detailed spectroscopic study of 19 CoRoT red-giant stars (Morel et al. 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars. This study is already published in Lagarde et al. (2015)

  20. The sacramental character of man and of creation

    Directory of Open Access Journals (Sweden)

    STOIAN Mihai Sebastian

    2016-06-01

    Full Text Available God made Himself a man for man to reach the likeness of God – this is the essential idea of the oikonomia of our salvation, dear to all the Church Fathers, from Saint Irenaeus to Saint Athanasius the Great and the essence of Christ, mystery and original and fundamental sacrament of our meeting with God and of our salvation, of all of us, in Christ, and of the acquisition by each man of the fruits of salvation and deification through Christ, in the Holy Spirit, in His Church. Christ’s mystery and sacrament begins by the Embodiment of the Father’s Logos. The Passions, the cross, the tomb and the resurrection are its continuation. And all these translate the mystery of the reason why God created everything and the very mystery of man - participating to the original mystery, namely Christ, and the Church, as sacrament. Therefore, Christ is the Mystery and the sacrament by excellence - original and general -, spring and content of all the mysteries and sacraments, condition and explanation of all these.

  1. Reference man models based on normal data from human populations

    International Nuclear Information System (INIS)

    Tanaka, Gi-ichiro; Kawamura, Hisao

    2000-01-01

    Quantitative description of the physical, and metabolic parameters of the human body is the very basic for internal dosimetry. Compilation of anatomical and other types of data Asian populations for internal (and external) dosimetry is of grate significance because of the potential spread of nuclear energy use in the Asian region and the major contribution of the region to the world population (about 58%). It has been observed that some differences exist for habitat, race, body sizes and pattern of food consumption. In the early stage of revision of ICRP Reference man by the Task Group, Characteristics of the human body of non-European populations received considerable attention as well as those of the European populations of different sexes and ages. In this context, an IAEA-RCA Co-ordinated Research Program on Compilation of Anatomical, Physiological and Metabolic Characteristics for a Reference Asian Man endorsed. In later stages of reference Man revision, anatomical data for Asians was discusses together with those of European populations, presumably due to ICRP's decision of unanimous use of the Reference Man for radiation protection. Reference man models for adults and 15, 10, 5, 1, 0 year-old males and females of Asian populations were developed for use in internal and external dosimetry. Based on the concept of ICRP Reference Man (Publication 23), the reference values were derived from the normal organ mass data for Japanese and statistical data on the physique and nutrition of Japanese and Chinese. Also incorporated were variations in physical measurements, as observed in the above mentioned IAEA-RCA Co-ordinated Research Program. The work was partly carried out within the activities of the ICRP Task Group on Reference Man. The weight of the skeleton was adjusted following the revised values in Publication 70. This paper will report basic shared and non-shared characteristics of Reference Man' for Asians and ICRP Reference Man. (author)

  2. Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist

    International Nuclear Information System (INIS)

    Akech, Jacqueline; Roy, Somdutta Sinha; Das, Salil K.

    2005-01-01

    Changes in phospholipid and fatty acid profile are hallmarks of cancer progression. Increase in peripheral benzodiazepine receptor expression has been implicated in breast cancer. The benzodiazepine, Ro5-4864, increases cell proliferation in some breast cancer cell lines. Biosynthesis of phosphatidylcholine (PC) has been identified as a marker for cells proliferating at high rates. Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC. We have addressed here whether Ro5-4864 facilitates some cancer causing mechanisms in breast cancer. We report that cell proliferation increases exponentially in aggressive breast cancer cell lines 11-9-1-4 and BT-549 when treated with nanomolar concentrations of Ro5-4864. This increase is seen within 24 h of treatment, consistent with the cell doubling time in these cells. Ro5-4864 also upregulates c-fos expression in breast cancer cell lines 11-9-1-4 and BT-549, while expression in non-tumorigenic cell line MCF-12A was either basal or slightly downregulated. We further examined the expression of the CPT gene in breast cancer (11-9-1-4, BT-549) and non-tumorigenic cell lines (MCF-12A, MCF-12F). We found that the CPT gene is overexpressed in breast cancer cell lines compared to the non-tumorigenic cell lines. Furthermore, the activity of CPT in forming PC is increased in the breast cancer cell lines cultured for 24 h. Additionally, we examined the CPT activity in the presence of nanomolar concentrations of Ro5-4864. Biosynthesis of PC was increased in breast cancer cell lines upon treatment. We therefore propose that Ro5-4864 facilitates PC formation, a process important in membrane biogenesis for proliferating cells

  3. Small reactor power systems for manned planetary surface bases

    Energy Technology Data Exchange (ETDEWEB)

    Bloomfield, H.S.

    1987-12-01

    A preliminary feasibility study of the potential application of small nuclear reactor space power systems to manned planetary surface base missions was conducted. The purpose of the study was to identify and assess the technology, performance, and safety issues associated with integration of reactor power systems with an evolutionary manned planetary surface exploration scenario. The requirements and characteristics of a variety of human-rated modular reactor power system configurations selected for a range of power levels from 25 kWe to hundreds of kilowatts is described. Trade-off analyses for reactor power systems utilizing both man-made and indigenous shielding materials are provided to examine performance, installation and operational safety feasibility issues. The results of this study have confirmed the preliminary feasibility of a wide variety of small reactor power plant configurations for growth oriented manned planetary surface exploration missions. The capability for power level growth with increasing manned presence, while maintaining safe radiation levels, was favorably assessed for nominal 25 to 100 kWe modular configurations. No feasibility limitations or technical barriers were identified and the use of both distance and indigenous planetary soil material for human rated radiation shielding were shown to be viable and attractive options.

  4. Small reactor power systems for manned planetary surface bases

    International Nuclear Information System (INIS)

    Bloomfield, H.S.

    1987-12-01

    A preliminary feasibility study of the potential application of small nuclear reactor space power systems to manned planetary surface base missions was conducted. The purpose of the study was to identify and assess the technology, performance, and safety issues associated with integration of reactor power systems with an evolutionary manned planetary surface exploration scenario. The requirements and characteristics of a variety of human-rated modular reactor power system configurations selected for a range of power levels from 25 kWe to hundreds of kilowatts is described. Trade-off analyses for reactor power systems utilizing both man-made and indigenous shielding materials are provided to examine performance, installation and operational safety feasibility issues. The results of this study have confirmed the preliminary feasibility of a wide variety of small reactor power plant configurations for growth oriented manned planetary surface exploration missions. The capability for power level growth with increasing manned presence, while maintaining safe radiation levels, was favorably assessed for nominal 25 to 100 kWe modular configurations. No feasibility limitations or technical barriers were identified and the use of both distance and indigenous planetary soil material for human rated radiation shielding were shown to be viable and attractive options

  5. PSYCHOLINGUISTIC CHARACTERISTICS OF AUTISTS AND THEIR PROTOTYPES IN AMERICAN CINEMA DISCOURSE (BASED ON THE FILMS RAIN MAN AND THE REAL RAIN MAN

    Directory of Open Access Journals (Sweden)

    L.M. Ikalyuk

    2015-09-01

    Full Text Available The article focuses on the study of the main characteristics of people with autistic spectrum disorders. The comparison between the famous American savant, Kim Peek, and his prototype in the American cinema discourse has been made on the basis of the films Rain Man and The Real Rain Man. With the help of psychographological analysis, the speech of the man and his fictional prototype has been examined. The analysis showed that the difference between the two persons is indubitable, which can be explained by the fact that the savant syndrome was caused by different disorders.

  6. Understanding A.M. Iqbal’s Vision on Perfect Man

    Directory of Open Access Journals (Sweden)

    Imam Bahroni

    2013-12-01

    Full Text Available This article tries to elucidate A.M Iqbal’s vision on the concept of perfectman. Its significance is at the point that Man can transform both his being andhis surroundings according to his own desires and aspirations. He actually makesimprovements upon what is created by God. God created night, he inventedthe lamp; God created clay, and from it he made the cup; God created deserts,mountains, forests, orchards, gardens, and groves. He makes glass out of stoneand turns poison into an antidote. God created the world, but he made it morebeautiful.Iqbal’s reasoning amply justifies belief in the ascendancy of man overthe universe and his predicted perfection. The perfect man is the ultimate endof the revolutionary process, and he is developed out of the present man, justas the full moon is developed from the crescent.

  7. Beneficial phosphate recovery from reverse osmosis (RO) concentrate of an integrated membrane system using polymeric ligand exchanger (PLE).

    Science.gov (United States)

    Kumar, Manish; Badruzzaman, Mohammad; Adham, Samer; Oppenheimer, Joan

    2007-05-01

    Phosphorus (P) discharge to surface water is a major environmental problem. Wastewater treatment is targeted towards removal of this nutrient to prevent degradation of surface water. Integrated membrane systems (IMS) are increasingly being considered for wastewater reclamation, and provide excellent removal of P compounds. However, reverse osmosis (RO), which forms an integral part of these IMSs, concentrates most dissolved substances including P-species such as phosphates in the RO waste stream. In this study, removal of phosphate from this stream using polymeric ligand exchange (PLE) resins was investigated. Further, the possibility of phosphate recovery through struvite (MgNH(4)PO(4).6H(2)O) precipitation was tested. Struvite has been promoted as a slow release fertilizer in recent years. This study demonstrates that PLEs can be successfully used to remove phosphate from RO-concentrate, and to recover more than 85% of the adsorbed phosphorus from the exhausted media and precipitated as a beneficial product (struvite). The approach, presented in this study, suggests advantages of providing economic benefit from a waste product (RO) while avoiding phosphorus discharge to the environment.

  8. Efficacy of an integrated continuing medical education (CME) and quality improvement (QI) program on radiation oncologist (RO) clinical practice

    International Nuclear Information System (INIS)

    Leong, Cheng Nang; Shakespeare, Thomas Philip; Mukherjee, Rahul K.; Back, Michael F.; Lee, Khai Mun; Lu, Jiade Jay; Wynne, Christopher J.; Lim, Keith; Tang, Johann; Zhang Xiaojian

    2006-01-01

    Purpose: There has been little radiation oncologist (RO)-specific research in continuing medical education (CME) or quality improvement (QI) program efficacy. Our aim was to evaluate a CME/QI program for changes in RO behavior, performance, and adherence to department protocols/studies over the first 12 months of the program. Methods and Materials: The CME/QI program combined chart audit with feedback (C-AWF), simulation review AWF (SR-AWF), reminder checklists, and targeted CME tutorials. Between April 2003 and March 2004, management of 75 patients was evaluated by chart audit with feedback (C-AWF) and 178 patients via simulation review audit (SR-AWF) using a validated instrument. Scores were presented, and case management was discussed with individualized educational feedback. RO behavior and performance was compared over the first year of the program. Results: Comparing the first and second 6 months, there was a significant improvement in mean behavior (12.7-13.6 of 14, p = 0.0005) and RO performance (7.6-7.9 of 8, p = 0.018) scores. Protocol/study adherence significantly improved from 90.3% to 96.6% (p = 0.005). A total of 50 actions were generated, including the identification of learning needs to direct CME tutorials, the systematic change of suboptimal RO practice, and the alteration of deficient management of 3% of patients audited during the program. Conclusion: An integrated CME/QI program combining C-AWF, SR-AWF, QI reminders, and targeted CME tutorials effectively improved targeted RO behavior and performance over a 12-month period. There was a corresponding increase in departmental protocol and study adherence

  9. Graphic man-machine interface applied to nuclear reactor designs

    International Nuclear Information System (INIS)

    Pereira, Claudio M.N.A; Mol, Antonio Carlos A.

    1999-01-01

    The Man-Machine Interfaces have been of interest of many researchers in the area of nuclear human factors engineering, principally applied to monitoring systems. The clarity of information provides best adaptation of the men to the machine. This work proposes the development of a Graphic Man-Machine Interface applied to nuclear reactor designs as a tool to optimize them. Here is present a prototype of a graphic man-machine interface for the Hammer code developed for PC under the Windows environment. The results of its application are commented. (author)

  10. Who is afraid of a black Spider(-Man)?

    OpenAIRE

    Ora C. McWilliams

    2013-01-01

    An Internet post asking about Spider-Man's race in a film turned into an Internet campaign about an actor that led fans to interact with each other as well as with the actor, which in turn led to the attention of media producers, which resulted in a change in Spider-Man's race in a print comic book.

  11. Environmental behaviour of radionuclides and transfer to man

    International Nuclear Information System (INIS)

    Smith, H.

    1982-01-01

    The environmental behaviour of the radionuclides making the major contribution to man's irradiation through diet is described. The following stages are emphasized: transfer of radionuclides to plants; transfer of radionuclides to animals; metabolism of inhaled or ingested radionuclides in animals providing food for man; transfer of radionuclides through the aquatic environment; application of food chain models. (43 references)

  12. Y a-t-il eu un instant zéro ?

    CERN Document Server

    Klein, Etienne

    2015-01-01

    D'où vient l'univers ? Et d'où vient même qu'il y ait un univers ? Aura-t-il une fin ? Pourquoi les humains y sont-ils apparus ? Si ces questions nous obsèdent depuis toujours, celle de l'origine demeure la plus mystérieuse, la plus vertigineuse, d'où la profusion de discours — mythologiques, religieux ou philosophiques — qui tentent d'y répondre. C'est grâce à la science, aux découvertes de Newton, Galilée, Edwin Hubble, Alexandre Friedmann et Georges Lemaître, qu'on peut retracer le grand récit de l'univers, remonter son histoire à 13,7 milliards d'années, jusqu'à cette phase très dense et très chaude qu'on a appelée le big bang. Mais celui-ci n'est pas pour autant, comme on l'a imaginé, cette explosion originelle qui aurait créé tout ce qui existe. Cet instant zéro, peut-on le décrire, le penser, raconter d'où il peut bien provenir ? Et d'où serait venu l'univers d'avant le big bang ? Mystère ! Qu'il y ait eu origine ou pas, on ne part donc jamais de zéro. En parler, c'est p...

  13. Crisis and Man: Literary Responses Across Cultures

    OpenAIRE

    Krishnaswami, Mallika

    2012-01-01

    Myth of Sisyphus exemplifies the situation man finds himself in irrespective of his ethnic and geographical background. Art and cultural forms gave expression to this situation and the intensity of the expression depended upon the political and social dimensions. War or peace, man is always condemned to struggle with his problems, moral or otherwise. Post war English writers focused on the social problems the British society found itself in and its helplessness in dealing with them. It was th...

  14. Oedipus king: preparing man for the polis

    Directory of Open Access Journals (Sweden)

    José Joaquim Pereira Melo

    2013-09-01

    Full Text Available Having Sophoclean play Oedipus King as a frame of reference, the purpose of this paper is to discuss the educative proposal conceived to the Greek Man as preparation for life in the polis. Although not intentionally, Sophocles pointed out an ideal of Man which, in his perspective, would fulfill Greek societal demands of that time. Such society was divided between myth and rationality and, as a result, Man found Himself in conflict and lacking direction for His life. Given that, Oedipus’ character represented the ideal behavior of that society, and it also made it possible for citizens to reflect and to discuss social, economic and political transformations taking place at that period. Thus Sophocles came up with a hero who was an educational model and a citizen’s as well. Furthermore, such hero differed from that one of the archaic Greek thought.

  15. 16th International Conference on Man-Machine-Environment System Engineering

    CERN Document Server

    Dhillon, Balbir

    2016-01-01

    This research topic was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science subject and technology in China!” MMESE primarily focuses on the relationship between Man, Machine and Environment, studying the optimum combination of man-machine-environment systems. In this system, “Man” refers to working people as the subject in the workplace (e.g. operators, decision-makers); “Machine” is the general name for any object controlled by Man (including tools, machinery, computers, systems and technologies), and “Environment” describes the specific working conditions under which Man and Machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization are to ensure "Safety, High efficiency and Economy" of man-machine-environment systems. These...

  16. ESR dating method and the age determination of Peking-Man

    International Nuclear Information System (INIS)

    Jin Sizhao; Liang Renyou; Huang Peihua

    1991-01-01

    ESR dating method and the age determination of the first skull of Zhoukoudian Beijing-Man have been introduced in this paper. Some animal fossil teeth, which are contemporaneous with the Beijing-Man, were used for determination of accumulative dose. The internal and environmental doses of the tooth samples were determined by neutron activation analysis and embeded thermoluminescence dosimeter at the site, respectively. The age of 578 ka of the first skull of Beijing-Man is calculated by the linear uranium accumulation model. According to the ESR dating results, author has given a chronological scale of the cave deposits Loc. 1, Beijing-man site and discussed the mean-life of trapped electron for dating

  17. Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes.

    Science.gov (United States)

    Lee, Hye-Jin; Kim, Hyung-Eun; Lee, Changha

    2017-03-01

    Combinations of Cu(II) with hydroxylamine (HA) and hydrogen peroxide (H 2 O 2 ) (i.e., Cu(II)/HA, Cu(II)/H 2 O 2 , and Cu(II)/HA/H 2 O 2 systems) were investigated for the control of P. aeruginosa biofilms on reverse osmosis (RO) membranes. These Cu(II)-based disinfection systems effectively inactivated P. aeruginosa cells, exhibiting different behaviors depending on the state of bacterial cells (planktonic or biofilm) and the condition of biofilm growth and treatment (normal or pressurized condition). The Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems were the most effective reagents for the inactivation of planktonic cells. However, these systems were not effective in inactivating cells in biofilms on the RO membranes possibly due to the interactions of Cu(I) with extracellular polymeric substances (EPS), where biofilms were grown and treated in center for disease control (CDC) reactors. Different from the results using CDC reactors, in a pressurized cross-flow RO filtration unit, the Cu(II)/HA/H 2 O 2 treatment significantly inactivated biofilm cells formed on the RO membranes, successfully recovering the permeate flux reduced by the biofouling. The pretreatment of feed solutions by Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems (applied before the biofilm formation) effectively mitigated the permeate flux decline by preventing the biofilm growth on the RO membranes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 196.13-1... VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  19. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 78.13-1... OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving Appliances and...

  20. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 97.13-1... VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  1. Removal of Pharmaceutical and Personal Care Products (PPCPs) from Municipal Waste Water with Integrated Membrane Systems, MBR-RO/NF.

    Science.gov (United States)

    Wang, Yonggang; Wang, Xu; Li, Mingwei; Dong, Jing; Sun, Changhong; Chen, Guanyi

    2018-02-05

    This study focuses on the application of combining membrane bioreactor (MBR) treatment with reverse osmosis (RO) or nanofiltration (NF) membrane treatment for removal of pharmaceuticals and personal care products (PPCPs) in municipal wastewater. Twenty-seven PPCPs were measured in real influent with lowest average concentration being trimethoprim (7.12 ng/L) and the highest being caffeine (18.4 ng/L). The results suggest that the MBR system effectively removes the PPCPs with an efficiency of between 41.08% and 95.41%, and that the integrated membrane systems, MBR-RO/NF, can achieve even higher removal rates of above 95% for most of them. The results also suggest that, due to the differences in removal mechanisms of NF/RO membrane, differences of removal rates exist. In this study, the combination of MBR-NF resulted in the removal of 13 compounds to below detection limits and MBR-RO achieved even better results with removal of 20 compounds to below detection limits.

  2. Physical characteristics of the Japanese in relation to reference man

    International Nuclear Information System (INIS)

    Tanaka, G.-i.; Kawamura, H.; Nomura, E.

    1980-01-01

    Quantitative description of physical and other characteristics of the human body provides basic data for the estimation of radiation risk and the establishment of dose equivalent in line with the International Commission on Radiological Protection recommendations. ICRP Reference Man is based essentially on data reported on populations in rather limited areas in the world although Committee 2 of ICRP concedes that ''it is neither feasible nor necessary to specify Reference Man as representative of a well-defined population group''. ICRP Reference Man is not necessarily based on the most recent available data. In order to be more realistic and quantitative in dose equivalent estimation in Japan, it is necessary to consider populations which are largely different from those of European and North American countries in physical dimensions and other aspects. Therefore, standard or reference values of mass and size of organs, body and organ content and metabolic parameters of some elements have been studied. These are compared with the values of ICRP Reference Man authorized up to now, with the intention of establishing ''Reference Japanese Man'' and contributing to the improvement of models of man used in radiation protection. Dose equivalent commitment and annual limit of intake have been calculated using the obtained data for the general population in Japan,for some nuclides. (H.K.)

  3. Who is afraid of a black Spider(-Man?

    Directory of Open Access Journals (Sweden)

    Ora C. McWilliams

    2013-06-01

    Full Text Available An Internet post asking about Spider-Man's race in a film turned into an Internet campaign about an actor that led fans to interact with each other as well as with the actor, which in turn led to the attention of media producers, which resulted in a change in Spider-Man's race in a print comic book.

  4. Man...An Endangered Species?

    Science.gov (United States)

    Department of the Interior, Washington, DC.

    The general theme of this 1968 yearbook is that man is a threatened species, facing overpopulation and unbridled technology - both self induced. The presentation is broad, relating to many aspects of conservation and natural resources in the United States in a descriptive, non-technical style. The yearbook is divided into major topics: Land…

  5. Man as a Species.

    Science.gov (United States)

    Solem, Alan; And Others

    Written in 1964, the document represents experimental material of the Anthropology Curriculum Study Project. The objectives of the project were to discuss the evolution of man as distinguished from the evolution of other species and as related to culture, and to emphasize human diversity. Three brief essays are presented. The first, "The…

  6. RoCoMAR: Robots' Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

    Science.gov (United States)

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2013-01-01

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay. PMID:23881134

  7. RoCoMAR: Robots’ Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

    Directory of Open Access Journals (Sweden)

    Seokhoon Yoon

    2013-07-01

    Full Text Available In a practical deployment, mobile sensor network (MSN suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots’ Controllable Mobility Aided Routing that uses robotic nodes’ controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

  8. MeltMan: Optimization, Evaluation, and Universal Application of a qPCR System Integrating the TaqMan qPCR and Melting Analysis into a Single Assay

    Science.gov (United States)

    Nagy, Alexander; Černíková, Lenka; Vitásková, Eliška; Křivda, Vlastimil; Dán, Ádám; Dirbáková, Zuzana; Jiřincová, Helena; Procházka, Bohumír; Sedlák, Kamil; Havlíčková, Martina

    2016-01-01

    In the present work, we optimised and evaluated a qPCR system integrating 6-FAM (6-carboxyfluorescein)-labelled TaqMan probes and melting analysis using the SYTO 82 (S82) DNA binding dye in a single reaction. We investigated the influence of the S82 on various TaqMan and melting analysis parameters and defined its optimal concentration. In the next step, the method was evaluated in 36 different TaqMan assays with a total of 729 paired reactions using various DNA and RNA templates, including field specimens. In addition, the melting profiles of interest were correlated with the electrophoretic patterns. We proved that the S82 is fully compatible with the FAM-TaqMan system. Further, the advantages of this approach in routine diagnostic TaqMan qPCR were illustrated with practical examples. These included solving problems with flat or other atypical amplification curves or even false negativity as a result of probe binding failure. Our data clearly show that the integration of the TaqMan qPCR and melting analysis into a single assay provides an additional control option as well as the opportunity to perform more complex analyses, get more data from the reactions, and obtain analysis results with higher confidence. PMID:27031831

  9. Tourismusbüro von Dubai in der Schweiz & Österreich: Analyse des Business Plan & Budget 2013

    OpenAIRE

    Wyss, Anja; Stampfli, Michèle

    2014-01-01

    Das Department of Tourism and Commerce Marketing of Dubai (DTCM) hat in der Schweiz ein Auslandbüro, das für die Märkte Schweiz und Österreich zuständig ist. Dieses Tourismusbüro ist in den beiden Ländern mehrheitlich für die touristische sowohl als auch für die ökonomische Vermarktung der Destination Dubai zuständig. Um die Marketingaktivitäten im Groben zu planen, wird jährlich ein Marketingkonzept erstellt, das jedoch nicht auf statistischen Werten oder einer detaillierten Marktanalyse bas...

  10. The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

    Science.gov (United States)

    Bateman, Alex; Kickhoefer, Valerie

    2003-10-16

    Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

  11. Improving Enlisted Fleet Manning

    Science.gov (United States)

    2014-07-01

    and FY totals) by rating, program, and gender for active and reserve accessions. Each quarter, the Navy holds a quarterly demand planning confer...The CS E-7, E-8, and E-9 his- torically have been undermanned at sea, but in FY 2014 the CS E-7 sea manning rate reached parity . Figure 55

  12. Effect of Variable Manning Coefficients on Tsunami Inundation

    Science.gov (United States)

    Barberopoulou, A.; Rees, D.

    2017-12-01

    Numerical simulations are commonly used to help estimate tsunami hazard, improve evacuation plans, issue or cancel tsunami warnings, inform forecasting and hazard assessments and have therefore become an integral part of hazard mitigation among the tsunami community. Many numerical codes exist for simulating tsunamis, most of which have undergone extensive benchmarking and testing. Tsunami hazard or risk assessments employ these codes following a deterministic or probabilistic approach. Depending on the scope these studies may or may not consider uncertainty in the numerical simulations, the effects of tides, variable friction or estimate financial losses, none of which are necessarily trivial. Distributed manning coefficients, the roughness coefficients used in hydraulic modeling, are commonly used in simulating both riverine and pluvial flood events however, their use in tsunami hazard assessments is primarily part of limited scope studies and for the most part, not a standard practice. For this work, we investigate variations in manning coefficients and their effects on tsunami inundation extent, pattern and financial loss. To assign manning coefficients we use land use maps that come from the New Zealand Land Cover Database (LCDB) and more recent data from the Ministry of the Environment. More than 40 classes covering different types of land use are combined into major classes such as cropland, grassland and wetland representing common types of land use in New Zealand, each of which is assigned a unique manning coefficient. By utilizing different data sources for variable manning coefficients, we examine the impact of data sources and classification methodology on the accuracy of model outputs.

  13. Conference on Manned Systems Design : New Methods and Equipment

    CERN Document Server

    Kraiss, K-F

    1981-01-01

    This volume contains the proceedings of a conference held in Freiburg, West Germany, September 22-25, 1980, entitled "Manned Systems Design, New Methods and Equipment". The conference was sponsored by the Special Programme Panel on Human Factors of the Scientific Affairs Division of NATO, and supported by Panel VIII, AC/243, on "Human and Biomedical Sciences". Their sponsorship and support are gratefully acknowledged. The contributions in the book are grouped according to the main themes of the conference with special emphasis on analytical approaches, measurement of performance, and simulator design and evaluat ion. The design of manned systems covers many and highly diversified areas. Therefore, a conference under the general title of "Manned Systems Design" is rather ambitious in itself. However, scientists and engineers engaged in the design of manned systems very often are confronted with problems that can be solved only by having several disciplines working together. So it was felt that knowledge about ...

  14. Homo Tangens, or Man Touching and Tangible

    OpenAIRE

    J Mizinska

    2011-01-01

    The article is devoted to the analysis of the concept sense of touch, which is considered in all its aspects and dimensions. The author's aim is to determine what is touch in terms of philosophy, what types it has and what traditional functions (i.e. prior to the emergence of virtual reality) each of these functions performed. The conducted research allows the author to make a conclusion about the importance of perceiving the role and significance of man as a homo tangens - man touching and t...

  15. 137Cs in man due to nuclear fallout

    International Nuclear Information System (INIS)

    Poulheim, K.F.

    1981-01-01

    137 Cs has been determined in man with the aid of a whole-body counter. It is shown that the specific 137 Cs content (as related to the potassium content in man) continuously decreased from 1965 through 1974. After a slight increase in 1975, possibly caused by a Chinese atmospheric nuclear test in June 1974, the 137 Cs content again decreased in the following years. (author)

  16. Man-midwifery history: 1730-1930.

    Science.gov (United States)

    Shelton, D C

    2012-11-01

    This paper seeks to determine whether the man-midwives William Smellie and William Hunter deserve continuing approbation as 'Founding Fathers' of the obstetrics profession. Scrutiny of their careers reveals their involvement in murders for dissection. In addition, the man-midwifery initiative of delivery in lying-in hospitals resulted in around 1 million more deaths in Britain and Ireland between 1730 and 1930, than would have occurred had home-births remained as the norm. While some may still credit Smellie and Hunter with obstetric discoveries, their knowledge was obtained by murder-for-dissection. That indictment, together with the lying-in hospital legacy, far outweighs their discoveries. The paper invites further constructive discussion and debate, but concludes the accolade of Founding Fathers is undeserved. Any continuing endorsement of Smellie and Hunter effectively demeans the high ethical standards and reputation of current obstetric professionals.

  17. Paleogeothermal record of the Emeishan mantle plume: evidences from borehole Ro data in the Sichuan basin, SW China

    Science.gov (United States)

    Hu, S.

    2013-12-01

    The Emeishan basalt province located in the southwest of China is widely accepted to be a result of the eruption of a mantle plume at the time of middle-late Permian. If it was a mantle plume, the ambient sedimentary rocks must be heated up during the development of the mantle plume and this thermal effect must be recorded by some geothermometers in the country rocks. The vitrinite reflectance (Ro) data as a maximum paleotemperature recorder from boreholes in Sichuan basin was employed to expose the thermal regime related to the proposed Emeishan mantle plume. The Ro profiles from boreholes which drilled close to the Emeishan basalts shows a ';dog-leg' (break) style at the unconformity between the middle and the upper Permian, and the Ro profiles in the lower subsection (pre-middle Permian) shows a significantly higher slopes (gradients) than those in the upper subsection. In contrast, those Ro profiles from boreholes far away from the center of the basalt province have no break at the uncomformity. Based on the chemical kinetic model of Ro, the paleo-temperature gradients for the upper and the lower subsections in different boreholes, as well as the erosion at the unconformity between the middle and the upper Permian, were reconstructed to reveal the variations of the temperature gradients and erosion thickness with geological time and space. Both the thermal regime and the erosion thickness together with their spatial variation (structure) provide strong geothermal evidence for the existence of the Emeishan mantle plume in the middle-late Permian.

  18. Metabolite analysis of [11C]Ro15-4513 in mice, rats, monkeys and humans

    International Nuclear Information System (INIS)

    Kida, T.; Noguchi, J.; Zhang, M.-R.; Suhara, T.; Suzuki, K.

    2003-01-01

    We performed in vitro and in vivo assays of the metabolism of [ 11 C]Ro15-4513 over time in the plasma of mice, rats, monkeys and humans, using a radio-HPLC equipped with a sensitive positron detector, in order to compare the metabolic rates of the radiopharmaceutical agent among the different animal species and to establish a highly sensitive analytical method for the radiotracer agent. We also examined the metabolism of [ 11 C]Ro15-4513 in the brain tissue of mice and rats. The analytical method used in this study permitted detection of even extremely low levels of radioactivity (approximately 5,000 dpm). In vitro experiments revealed that [ 11 C]Ro15-4513 in the blood was metabolized to hydrolysate [ 11 C]A. The species were classified in descending order of the metabolic rate of the radiotracer in vitro as follows; mice, rats, and monkeys/humans. In the in vitro experiment, the percentage of the unchanged drug in the plasma at 60 minutes postdose was 9% in mice, 70% in rats, 97% in monkeys, and 98% in humans. In vivo metabolite analysis in the blood showed the presence of two radioactive metabolites, consisting of one hydrolysate [ 11 C]A and another unidentified substance. The species were classified in descending order of the metabolic rate of the radiotracer in vivo as follows; mice, rats/humans, and monkeys. The percentage of the unchanged drug in the plasma was 6% in mice, 21% in rats, 26% in humans, and 40% in monkeys. Furthermore, the in vitro and in vivo experiments conducted to analyze the metabolism of [ 11 C]Ro15-4513 in the brain tissue of mice and rats revealed that the radiotracer was metabolized to some extent in the brain tissue of these animals. In the in vivo experiment, the percentage of the unchanged drug at 60 min postdose was 86% in the brain tissue of mice and 88% in the brain tissue of rats, while in the in vitro experiment, the corresponding percentage was 93% in mice, and 91% in rats

  19. Partial agonist of benzodiazepine receptors Ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats

    Czech Academy of Sciences Publication Activity Database

    Kubová, Hana; Mareš, Pavel

    2012-01-01

    Roč. 61, č. 3 (2012), s. 319-323 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA305/09/0846; GA ČR(CZ) GBP304/12/G069 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 Keywords : Ro 19-2088 * iatrogenic withdrawal * pentylentetrazol-induced seizures * immature rats Subject RIV: FH - Neurology Impact factor: 1.531, year: 2012

  20. 77 FR 21555 - Manning, Richard W.; Notice of Filing

    Science.gov (United States)

    2012-04-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6835-001] Manning, Richard W.; Notice of Filing Take notice that on April 2, 2012, Richard W. Manning submitted for filing... not serve to make protestants parties to the proceeding. Any person wishing to become a party must...

  1. Reference Japanese man

    International Nuclear Information System (INIS)

    Tanaka, G.-I.; Kawamura, H.; Nakahara, Y.

    1979-01-01

    The weight of organs from autopsy cases of normal Japanese adults, children, and infants is presented for the purpose of approaching a Reference Japanese Man. The skeletal content and the daily intake of alkaline earth elements are given. A lower rate of transfer (K 2 ) to the thyroid gland of ingested radioiodine, as well as a remarkably shorter biological half-life than the data adopted by ICRP, is also proved as a result of this study. (author)

  2. Man and computer

    International Nuclear Information System (INIS)

    Fischbach, K.F.

    1981-01-01

    The discussion of cultural and sociological consequences of computer evolution is hindered by human prejudice. For example the sentence 'a computer is at best as intelligent as its programmer' veils actual developments. Theoretical limits of computer intelligence are the limits of intelligence in general. Modern computer systems replace not only human labour, but also human decision making and thereby human responsibility. The historical situation is unique. Human head-work is being automated and man is loosing function. (orig.) [de

  3. Inventory of Onshore Hydrocarbon Seeps in Romania (HYSED-RO Database

    Directory of Open Access Journals (Sweden)

    Artur Ionescu

    2017-06-01

    Full Text Available Seeps are the expression of the migration of hydrocarbons from subsurface accumulations to the surface in sedimentary basins. They may represent an important indication of the presence of petroleum (gas and oil reservoirs and faults, and are a natural source of greenhouse gas (methane and atmospheric pollutants (ethane, propane to the atmosphere. Romania is one of the countries with the largest number of seeps in the world, due to the high petroleum potential and active tectonics. Based on a review of the available literature, and on the field surveys performed by the authors during the last 17 years, we report the first comprehensive GIS-based inventory of 470 seeps in Romania (HYSED-RO, including gas seeps (10.4% of the total, oil seeps (11.7%, mud volcanoes (50.4%, gas-rich springs (12.6%, asphalt (solid seeps (4.3%, unclassified manifestations (4.0%, and uncertain seeps (6.6%. Seeps are typically located in correspondence with major faults and vertical and fractured stratigraphic contacts associated to petroleum reservoirs (anticlines in low heat flow areas, and their gas-geochemistry reflects that of the subsurface reservoirs. The largest and most active seeps occur in the Carpathian Foredeep, where they release thermogenic gas, and subordinately in the Transylvanian Basin, where gas is mainly microbial. HYSED-RO may represent a key reference for baseline characterization prior to subsurface petroleum extraction, for environmental studies, and atmospheric greenhouse gas emission estimates in Romania.

  4. Some similarities of radium and plutonium toxicity in the beagle and man

    International Nuclear Information System (INIS)

    Taylor, G.N.; Jee, W.S.S.; Mays, C.W.

    1976-01-01

    The value of many toxicity studies, involving various experimental animals, is contingent on how reliably the data can be related to man. An equation has been proposed for extrapolating the Pu syndrome from dog studies to man. It employs the extensive human radium experience and a plutonium-radium toxicity ratio in the dog. The validity of this method is contingent on similar target tissues for both Pu and Ra and approximately equal RBE's for Pu relative to Ra in both man and the dog. Thus, although the radiosensitivity might be significantly different, the endpoints within a given tissue in man and the animal model must necessarily be comparative. The degree of parallelism in the radium-induced syndromes of man and the beagle are examined in order to assess the practicability of estimating Pu risk in man through use of a Pu-Ra toxicity ratio in the beagles

  5. "I Am Chelsea Manning": Comparison of Gendered Representation of Private Manning in U.S. and International News Media.

    Science.gov (United States)

    Hackl, Andrea M; Becker, Amy B; Todd, Maureen E

    2016-01-01

    On August 22, 2013, Bradley Manning released a statement requesting to be referred to as female. In the following days, the news media discussed whether language should shift toward a female representation. Using quantitative content analysis and qualitative contextual analysis, this study analyzed whether U.S. and international newspapers (N = 197) acknowledged Manning's request to be referred to as "Chelsea" in the two weeks after the statement. Results suggest that the mainstream press was hesitant in shifting toward a female representation. A comparison of international and U.S. newspapers suggests that the U.S. press lagged behind international coverage using a female depiction.

  6. Ocular bacillary angiomatosis in an immunocompromised man.

    Science.gov (United States)

    Murray, Meltzer A; Zamecki, Katherine J; Paskowski, Joseph; Lelli, Gary J

    2010-01-01

    An immunocompromised man presented with an inflammatory eyelid lesion. Biopsy was performed; histopathology and special staining confirmed a diagnosis of bacillary angiomatosis. The man was treated with oral erythromycin, and the lesion resolved. The etiologic agents of bacillary angiomatosis are Bartonella henselae and Bartonella quintana, Gram-negative coccobacilli. The organisms stain positively with the Warthin-Starry silver stain. Lesions can be cutaneous or visceral and have been commonly described in immunocompromised patients. Histopathologic examination of lesions reveals angiogenesis and cellular proliferation. Bacillary angiomatosis can be treated with oral antibiotics.

  7. Homo Tangens, or Man Touching and Tangible

    Directory of Open Access Journals (Sweden)

    J Mizinska

    2011-09-01

    Full Text Available The article is devoted to the analysis of the concept sense of touch, which is considered in all its aspects and dimensions. The author's aim is to determine what is touch in terms of philosophy, what types it has and what traditional functions (i.e. prior to the emergence of virtual reality each of these functions performed. The conducted research allows the author to make a conclusion about the importance of perceiving the role and significance of man as a homo tangens - man touching and tangible.

  8. Ke stému ročníku Chemických Listů

    Czech Academy of Sciences Publication Activity Database

    Holý, Petr

    2006-01-01

    Roč. 100, č. 4 (2006), s. 227-232 ISSN 0009-2770 Keywords : history and significance of the journal * notable members of editorial board Subject RIV: CC - Organic Chemistry Impact factor: 0.431, year: 2006

  9. Understanding and modelling man-machine interaction

    International Nuclear Information System (INIS)

    Cacciabue, P.C.

    1996-01-01

    This paper gives an overview of the current state of the art in man-machine system interaction studies, focusing on the problems derived from highly automated working environments and the role of humans in the control loop. In particular, it is argued that there is a need for sound approaches to the design and analysis of man-machine interaction (MMI), which stem from the contribution of three expertises in interfacing domains, namely engineering, computer science and psychology: engineering for understanding and modelling plants and their material and energy conservation principles; psychology for understanding and modelling humans an their cognitive behaviours; computer science for converting models in sound simulations running in appropriate computer architectures. (orig.)

  10. Understanding and modelling Man-Machine Interaction

    International Nuclear Information System (INIS)

    Cacciabue, P.C.

    1991-01-01

    This paper gives an overview of the current state of the art in man machine systems interaction studies, focusing on the problems derived from highly automated working environments and the role of humans in the control loop. In particular, it is argued that there is a need for sound approaches to design and analysis of Man-Machine Interaction (MMI), which stem from the contribution of three expertises in interfacing domains, namely engineering, computer science and psychology: engineering for understanding and modelling plants and their material and energy conservation principles; psychology for understanding and modelling humans and their cognitive behaviours; computer science for converting models in sound simulations running in appropriate computer architectures. (author)

  11. Brain perfusion imaging using a Reconstruction-of-Difference (RoD) approach for cone-beam computed tomography

    Science.gov (United States)

    Mow, M.; Zbijewski, W.; Sisniega, A.; Xu, J.; Dang, H.; Stayman, J. W.; Wang, X.; Foos, D. H.; Koliatsos, V.; Aygun, N.; Siewerdsen, J. H.

    2017-03-01

    Purpose: To improve the timely detection and treatment of intracranial hemorrhage or ischemic stroke, recent efforts include the development of cone-beam CT (CBCT) systems for perfusion imaging and new approaches to estimate perfusion parameters despite slow rotation speeds compared to multi-detector CT (MDCT) systems. This work describes development of a brain perfusion CBCT method using a reconstruction of difference (RoD) approach to enable perfusion imaging on a newly developed CBCT head scanner prototype. Methods: A new reconstruction approach using RoD with a penalized-likelihood framework was developed to image the temporal dynamics of vascular enhancement. A digital perfusion simulation was developed to give a realistic representation of brain anatomy, artifacts, noise, scanner characteristics, and hemo-dynamic properties. This simulation includes a digital brain phantom, time-attenuation curves and noise parameters, a novel forward projection method for improved computational efficiency, and perfusion parameter calculation. Results: Our results show the feasibility of estimating perfusion parameters from a set of images reconstructed from slow scans, sparse data sets, and arc length scans as short as 60 degrees. The RoD framework significantly reduces noise and time-varying artifacts from inconsistent projections. Proper regularization and the use of overlapping reconstructed arcs can potentially further decrease bias and increase temporal resolution, respectively. Conclusions: A digital brain perfusion simulation with RoD imaging approach has been developed and supports the feasibility of using a CBCT head scanner for perfusion imaging. Future work will include testing with data acquired using a 3D-printed perfusion phantom currently and translation to preclinical and clinical studies.

  12. Oscillations in roAp and & Scuti Stars : Theory and observations

    OpenAIRE

    Pinheiro, Fernando Jorge Gutiérrez

    1999-01-01

    As estrelas d Scuti e as estrelas roAp encontram-se na região da Faixa de Instabilidade das Cefeides que é atravessada pela Sequência principal. Cada tipo de estrelas apresenta frequências de oscilação que o outro género de estrelas não apresenta. Estas oscilações dependem da estrutura das estrelas, e podem ser descritas pelos modelos apropriados.De modo inverso, podemos a partir de observações obter as características de uma estrela, usando os modelos adequados.Discutiremos os modos de obter...

  13. Pathways to man

    International Nuclear Information System (INIS)

    Harley, J.H.

    1980-01-01

    The study of radionuclide pathways leading to man generally has the goal of allowing us to predict human exposure from measurements of the radionuclide concentration in some segment of the environment. This modelling process provides a valuable tool in both the regulatory and health protection fields. However, most of the models in the regulatory field and in the health physics profession were designed to maximize exposure estimates. It is preferable to have scientifically defensible estimates and to add suitable safety factors at the end. Thus we are still faced with the development and validation of suitable models for many of the radionuclides of interest. The most useful models will include means of assessing variability and uncertainty. In this case variability might be considered as the differences in behavior due to age, sex or other factors in animals or man and those differences among plant species or animal species that determine their uptake factors. The uncertainty, on the other hand, would be the estimate of possible error in the experimental measurements. Model parameters would always have some variability even for site-specific cases and broad averages for population groups would have to include a factor expressing the possible variabilty and uncertainity. Thus any exposure calculation would have to be expressed with some range and valid assessments of this range are required

  14. Compilation of anatomical, physiological and metabolic characteristics for a Bangladeshi man

    International Nuclear Information System (INIS)

    Fazle Karim Miah, M.D.; Rab Molla, M.A.; Begum, M.

    1998-01-01

    A study has been made to obtain/collect sex specific data on human physical parameters of Bangladeshi population of 9 age groups covering all ages for establishing a Bangladeshi/Asian Reference Man for radiation protection purposes. Eleven physical parameters were considered for measurement, namely height and weight of the total body, sitting height, chest girth, combined height of head and neck, head circumference, head width, neck circumference, length of arm, circumference of arm and length of leg. Significant variation in values of respective parameters was observed in most cases between male and female populations of the same age group. The measured values were compared with those of ICRP Reference Man of Caucasian origin. It is observed that the values of physical parameters of Caucasian Reference Man are systematically and probably significantly higher than those of the corresponding Bangladeshi Reference Man. The weights of male and female population of Caucasian Reference Man are approximately 20-30% higher than those of the corresponding Bangladeshi man. Since the organs of the body are roughly proportional to the body weight, the respective masses of the organs would be different by the same ratio factor and could be used for internal dosimetry purposes. (author)

  15. Mathematical Verification for Transmission Performance of Centralized Lightwave WDM-RoF-PON with Quintuple Services Integrated in Each Wavelength Channel

    Directory of Open Access Journals (Sweden)

    Shuai Chen

    2015-01-01

    Full Text Available Wavelength-division-multiplexing passive-optical-network (WDM-PON has been recognized as a promising solution of the “last mile” access as well as multibroadband data services access for end users, and WDM-RoF-PON, which employs radio-over-fiber (RoF technique in WDM-PON, is even a more attractive approach for future broadband fiber and wireless access for its strong availability of centralized multiservices transmission operation and its transparency for bandwidth and signal modulation formats. As for multiservices development in WDM-RoF-PON, various system designs have been reported and verified via simulation or experiment till now, and the scheme with multiservices transmitted in each single wavelength channel is believed as the one that has the highest bandwidth efficiency; however, the corresponding mathematical verification is still hard to be found in state-of-the-art literature. In this paper, system design and data transmission performance of a quintuple services integrated WDM-RoF-PON which jointly employs carrier multiplexing and orthogonal modulation techniques, have been theoretically analyzed and verified in detail; moreover, the system design has been duplicated and verified experimentally and the theory system of such WDM-RoF-PON scheme has thus been formed.

  16. Man and SuperNature. Lecture 12, September 27, 1946

    Science.gov (United States)

    Montessori, Maria

    2015-01-01

    "Man and SuperNature" is a lyrical chapter in the 1946 London course following the emergence of Cosmic Education in Kodaikanal, India. Montessori contrasts the adaptation required of animals for their survival to conscious human adaptation. Animals exist and adapt to nature, but man can alter nature and change the environment.…

  17. 77 FR 20882 - Manning Grain Company; Acquisition and Operation Exemption; Fillmore Western Railway Company

    Science.gov (United States)

    2012-04-06

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35612] Manning Grain Company; Acquisition and Operation Exemption; Fillmore Western Railway Company Manning Grain Company (MGC... Docket No. FD 35607, Manning Rail, Inc.--Acquisition and Operation Exemption--Manning Grain Company...

  18. Man and the Pongolo floodplain

    CSIR Research Space (South Africa)

    Heeg, J

    1982-06-01

    Full Text Available This report comprises a synthesis of contributions to a workshop on Man and the Pongolo held at the University of Natal, Pietermaritzburg in February 1978. Studies on the ecology of the Pongolo floodplain, encompassing its fauna, flora and human...

  19. Estimator's electrical man-hour manual

    CERN Document Server

    Page, John S

    1999-01-01

    This manual's latest edition continues to be the best source available for making accurate, reliable man-hour estimates for electrical installation. This new edition is revised and expanded to include installation of electrical instrumentation, which is used in monitoring various process systems.

  20. TaxMan: a taxonomic database manager

    Directory of Open Access Journals (Sweden)

    Blaxter Mark

    2006-12-01

    Full Text Available Abstract Background Phylogenetic analysis of large, multiple-gene datasets, assembled from public sequence databases, is rapidly becoming a popular way to approach difficult phylogenetic problems. Supermatrices (concatenated multiple sequence alignments of multiple genes can yield more phylogenetic signal than individual genes. However, manually assembling such datasets for a large taxonomic group is time-consuming and error-prone. Additionally, sequence curation, alignment and assessment of the results of phylogenetic analysis are made particularly difficult by the potential for a given gene in a given species to be unrepresented, or to be represented by multiple or partial sequences. We have developed a software package, TaxMan, that largely automates the processes of sequence acquisition, consensus building, alignment and taxon selection to facilitate this type of phylogenetic study. Results TaxMan uses freely available tools to allow rapid assembly, storage and analysis of large, aligned DNA and protein sequence datasets for user-defined sets of species and genes. The user provides GenBank format files and a list of gene names and synonyms for the loci to analyse. Sequences are extracted from the GenBank files on the basis of annotation and sequence similarity. Consensus sequences are built automatically. Alignment is carried out (where possible, at the protein level and aligned sequences are stored in a database. TaxMan can automatically determine the best subset of taxa to examine phylogeny at a given taxonomic level. By using the stored aligned sequences, large concatenated multiple sequence alignments can be generated rapidly for a subset and output in analysis-ready file formats. Trees resulting from phylogenetic analysis can be stored and compared with a reference taxonomy. Conclusion TaxMan allows rapid automated assembly of a multigene datasets of aligned sequences for large taxonomic groups. By extracting sequences on the basis of

  1. A modified CoRoT detrend algorithm and the discovery of a new planetary companion

    Science.gov (United States)

    Boufleur, Rodrigo C.; Emilio, Marcelo; Janot-Pacheco, Eduardo; Andrade, Laerte; Ferraz-Mello, Sylvio; do Nascimento, José-Dias, Jr.; de La Reza, Ramiro

    2018-01-01

    We present MCDA, a modification of the COnvection ROtation and planetary Transits (CoRoT) detrend algorithm (CDA) suitable to detrend chromatic light curves. By means of robust statistics and better handling of short-term variability, the implementation decreases the systematic light-curve variations and improves the detection of exoplanets when compared with the original algorithm. All CoRoT chromatic light curves (a total of 65 655) were analysed with our algorithm. Dozens of new transit candidates and all previously known CoRoT exoplanets were rediscovered in those light curves using a box-fitting algorithm. For three of the new cases, spectroscopic measurements of the candidates' host stars were retrieved from the ESO Science Archive Facility and used to calculate stellar parameters and, in the best cases, radial velocities. In addition to our improved detrend technique, we announce the discovery of a planet that orbits a 0.79_{-0.09}^{+0.08} R⊙ star with a period of 6.718 37 ± 0.000 01 d and has 0.57_{-0.05}^{+0.06} RJ and 0.15 ± 0.10 MJ. We also present the analysis of two cases in which parameters found suggest the existence of possible planetary companions.

  2. Are you Wo(man enough to get married?

    Directory of Open Access Journals (Sweden)

    Tiurma M. P. Allagan

    2016-12-01

    Full Text Available Indonesian marriage states that marriage is physical and spiritual relationship between a man and a woman as husband and wife in order to create an eternal happy family based on the Almighty God. This definition reflects that the marriage in Indonesia must be between heterosexual couple. However, a question appears as to whether a man or a woman mentioned thereof is included a man and a woman who were, hermaphrodite, intersex, or nowadays known as person with Disorder of Sexual Development (DSD? The case of AH whereby his marriage is cancelled by the Supreme Court in 2014 for he is not considered as a man, is confirming that this question is important to value the capacity of a person to marry. This writing will apply normative research as well as literature research method upon the positive rules and regulations. The decisions of district courts upon the revision or change of gender and its legal basis will be analysed and be the topic of discussion. Comparison will be applied to compare the marriage requirements between Indonesian Law, Singapore Law and Hong Kong Law. The results of analyse and discussion will be the closure of the writing, as conclusions and advise, if any.

  3. The CANDU man-machine interface and simulator training

    International Nuclear Information System (INIS)

    Hinchley, E.M.; Yanofsky, N.

    1982-09-01

    The most significant features of the man-machine interface for CANDU power stations are the extensive use of computer-driven colour graphics displays and the small number of manual controls. The man-machine interface in CANDU stations is designed to present the operator with concise, easy-to-understand information. Future developments in the use of computers in safety shutdown systems, and the use of data highway technologies in plant regulating systems will present special requirements and new opportunities in the application of human factors engineering to the control room. Good man-machine interaction depends on operator training as much as on control room design. In Canada computerized training simulators, which indicate plant response to operator action, are being introducted for operator training. Such simulators support training in normal operation of all plant systems and also in the fault management tasks following malfunctions

  4. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 73; Issue 6. Magnons interaction of spinor Bose–Einstein condensates in an optical lattice. Yong-Qing Liu. Volume 73 Issue 6 ... Author Affiliations. Yong-Qing Liu1. Department of Physics and Electronics, XinZhou Teachers University, XinZhou, 034000, China ...

  5. Pathways of evolution for man and machine

    Science.gov (United States)

    Mclaughlin, W. I.

    1983-01-01

    A simplified model of the future is introduced in order to examine the relations between man, machine, and extraterrestrial intelligence. The observed lack of extraterrestrials on earth is used as a boundary condition for the model. Two exobiological conclusions are obtained: (1) advanced extraterrestrials exist but are difficult to observe or to distinguish from natural phenomena, (2) lower level, man-like extraterrestrials, which are potentially observable, are rare in the Universe because they are rapidly replaced in the evolutinary sequence by the intelligent machines which they create. The decline of man is inferred and may take place as soon as 100 years from now or as long as 100,000 years from the present time. Thus, we are a short-lived species, having a life expectancy of only a million years. A note is appended on the rationale and methods of the search for extraterrestrial intelligence in light of the above calculations. The Tau Ceti and Epsilon Eridani systems present favourable opportunities for a radio-search experiment in 1987 and 1988, respectively.

  6. Manned spaceflight log II—2006–2012

    CERN Document Server

    Shayler, David J

    2013-01-01

    April 12, 1961 "Attention! This is Radio Moscow speaking...The world's first satellite spaceship, Vostock, with a man aboard, was put into orbit round the Earth." Soviet Union cosmonaut Yuri A. Gagarin becomes the first person to fly in space, completing one orbit in 108 minutes. April 5, 2001 As NASA prepares to fly the final Shuttle missions to the International Space Station, Russia launches Soyuz TMA 21 (code-named 'Yuri Gagarin') with the 28th ISS Expedition crew aboard, celebrating 50 years of manned spaceflight. Meanwhile, in China, preparations continue for launching the nation's first Space Station (called Tiangong 1 - or Heavenly Palace 1) later in the year. The sixth decade of manned spaceflight orbital operations has truly began. At this point in the history of human space exploration, it is timely to review the first five decades of adventure and look forward to the next decade and what it might bring. Several notable anniversaries celebrated in 2011 make it the right time to reflect and pay homa...

  7. Man-machine design integration

    Energy Technology Data Exchange (ETDEWEB)

    Carrera, J.P. [Westinghouse Electric Corp., Monroeville, PA (United States). Nuclear Technology Div.; Haentjens, J. [Westinghouse Electric Corp., Brussels (Belgium). Nuclear Technology Div.

    1995-12-31

    The presentation overviews the bases for Man-Machine Interface (MMI) designs that are part of three other presentations during the same conference: Advanced Alarm Management System, Functional Displays and System for Emergency Procedure Execution Monitoring. The MMD group history, team and goals are summarized to give some context to the core of the MMD philosophy and integration. (10 refs., 5 figs.).

  8. Adsorção dos corantes RO16, RR2 e RR141 utilizando lodo residual da indústria têxtil Adsorption of dyes RO16, RR2 and RR141 using residual sludge of textile industry

    Directory of Open Access Journals (Sweden)

    Andressa Regina Vasques

    2011-09-01

    Full Text Available A adsorção é uma das técnicas empregadas com sucesso para remoção efetiva da cor presente em efluentes têxteis. Com o objetivo de avaliar os diferentes parâmetros adsortivos, bem como determinar a eficiência de um adsorvente alternativo desenvolvido a partir de lodo residual têxtil na remoção de corantes, foram determinadas curvas de cinética de adsorção e isotermas. Por meio dos dados cinéticos e de equilíbrio obtidos, verificou-se que a 25ºC a adsorção foi favorável para todos os corantes, sendo esta a melhor condição para os corantes RO16 e RR2 na ausência de sais. Para o corante RR141, a adição de NaCl aumentou a capacidade de adsorção do adsorvente no equilíbrio e a adição de Na2SO4 favoreceu a adsorção para o corante RO16, ao contrário do que se observou para os outros dois corantes. A quantidade máxima de corante adsorvida por unidade de massa de adsorvente (q max nas melhores condições adsortivas para os corantes RO16, RR2 e RR141 foi de 81,30, 53,48 e 78,74 mg.g-1, respectivamente.The adsorption is one of the techniques that have been successfully used for effective removal of the dyes present in textile effluents. With the objective to evaluate the different adsorptive parameters, as well as determining the efficiency of one alternative adsorbent in the removal of dyes, kinetics and equilibrium data of adsorption were determined. By the kinetic data and of equilibrium, it was verified that the adsorption was favorable for all the dyes in 25ºC, being the best condition for the dye RO16 and RR2 in the total absence of salt. For the dye RR141, the addition of NaCl increased the adsorption capacity of adsorbent in the equilibrium and the addition of Na2SO4 favored the adsorption for the dye RO16, in contrast to what was observed for the two other dyes. The maximum quantity of dye adsorbed per unit mass of adsorbent (q max in the best adsorptive conditions for the dyes RO16, RR2 and RR141 was of 81

  9. Phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics

    International Nuclear Information System (INIS)

    Newman, H.F.; Bleehen, N.M.; Workman, P.

    1986-01-01

    The hypoxic cell radiosensitizer Ro 03-8799 produces acute central nervous system toxicity which limits repeated doses of the drug to 0.75 g/m 2 , but peripheral neuropathy does not occur. SR-2508 causes no acute effects at doses greater than 3.0 g/m 2 , but causes peripheral neuropathy at cumulative doses of 30 g/m 2 . By combining maximum tolerated doses of each agent, it may be possible to increase efficacy, but not toxicity. Escalating single doses of Ro 03-8799 and SR-2508 were administered to 10 patients. The drugs were infused together in 50 ml of 0.9% saline over 10 min, beginning at 0.5 g/m 2 of each agent, and proceeding to a fixed dose of 0.75 g/m 2 Ro 03-8799 with 0.5, 1.0, 2.0, and 3.0 g/m 2 SR-2508. Four patients experienced the expected acute syndrome related to Ro 03-8799, but the incidence was not increased by escalating doses of SR-2508, and no peripheral neuropathy was seen. Plasma and urine pharmacokinetic studies showed that no drug interaction occurred. Six patients have been given a 9-dose regime over a 3 week period, using 0.75 g/m 2 Ro 03-8799 and escalating doses of 0.5, 1.0, and 1.5 g/m2 SR-2508. All exhibited the expected acute side effects related to Ro 03-8799, but with no increase at the higher doses of SR-2508. No other toxicity was seen. Plasma pharmacokinetics performed at the beginning and end of the schedule were similar. Biopsies were taken from six superficial tumors following combined radiosensitizer administration. Mean tumor concentrations over the 30 min following the end of infusion were 30 and 72 micrograms/g for Ro 03-8799 and SR-2508, respectively. These values would be expected to translate into an approximate single dose sensitizer enhancement ratio of 1.5 to 1.6, offering a significant gain over the enhancement possible with the drugs given alone

  10. Physical, anatomical, physiological and metabolic data for reference Indian man - a proposal

    Energy Technology Data Exchange (ETDEWEB)

    Dang, H S; Jaiswal, D D; Parameswaran, M; Krishnamony, S [Bhabha Atomic Research Centre, Bombay (India). Health Physics Div.

    1994-12-31

    The collation and generation of data on physical, anatomical, physiological and metabolic characteristics of Indian subjects were carried out to set up a Reference Indian Man for radiation protection. A comparison of the Reference Indian Man data with the corresponding data for ICRP Reference Man, clearly showed that the physical, anatomical and metabolic characteristics were in general smaller for Reference Indian Man. A few of the physiological characteristics such as the daily consumption of drinking water, sweat rate were however, found to be higher, and the minute volume was similar for Reference Indian, in comparison to the ICRP Reference Man. The details of various human characteristics representative of the Indian population are reported in this paper. (author). 43 refs., 25 tabs., 6 figs.

  11. Physical, anatomical, physiological and metabolic data for reference Indian man - a proposal

    International Nuclear Information System (INIS)

    Dang, H.S.; Jaiswal, D.D.; Parameswaran, M.; Krishnamony, S.

    1994-01-01

    The collation and generation of data on physical, anatomical, physiological and metabolic characteristics of Indian subjects were carried out to set up a Reference Indian Man for radiation protection. A comparison of the Reference Indian Man data with the corresponding data for ICRP Reference Man, clearly showed that the physical, anatomical and metabolic characteristics were in general smaller for Reference Indian Man. A few of the physiological characteristics such as the daily consumption of drinking water, sweat rate were however, found to be higher, and the minute volume was similar for Reference Indian, in comparison to the ICRP Reference Man. The details of various human characteristics representative of the Indian population are reported in this paper. (author). 43 refs., 25 tabs., 6 figs

  12. Not normally manned compression platforms for the North Sea

    International Nuclear Information System (INIS)

    Kumaran, K.S.

    1994-01-01

    Gas turbine driven gas compressors have been widely used on manned offshore facilities. Similarly unmanned gas turbine driven compressor stations have been in operation onshore with major gas transmission companies in Europe, North America and elsewhere. This paper summarizes a recent joint industry study to investigate the technical and economic feasibility of Not Normally Manned (NNM) Offshore Compression Facilities in terms of reliability, availability and maintainability. Classification of not normally manned (or unmanned) offshore facilities in the UK North Sea is in accordance with HSE Operations Notice 8. ON8 specifies criteria for offshore visits, visit hours and number of personnel on board for the operation of NNM platforms. This paper describes a typical Southern North Sea gas platform being considered for NNM compressor application. The conclusions from the study was that NNM compression is technically feasible with the facilities being able to provide an availability in excess of 98%. Life cycle costs were of the order of 70% of manned facilities thus significantly improving field development economics

  13. Space nuclear reactor shields for manned and unmanned applications

    International Nuclear Information System (INIS)

    McKissock, B.I.; Bloomfield, H.S.

    1990-01-01

    Missions which use nuclear reactor power systems require radiation shielding of payload and/or crew areas to predetermined dose rates. Since shielding can become a significant fraction of the total mass of the system, it is of interest to show the effect of various parameters on shield thickness and mass for manned and unmanned applications. Algorithms were developed to give the thicknesses needed if reactor thermal power, separation distances and dose rates are given as input. The thickness algorithms were combined with models for four different shield geometries to allow tradeoff studies of shield volume and mass for a variety of manned and unmanned missions. The shield design tradeoffs presented in this study include the effects of: higher allowable dose rates; radiation hardened electronics; shorter crew exposure times; shield geometry; distance of the payload and/or crew from the reactor; and changes in the size of the shielded area. Specific NASA missions that were considered in this study include unmanned outer planetary exploration, manned advanced/evolutionary space station and advanced manned lunar base. (author)

  14. Space nuclear reactor shields for manned and unmanned applications

    International Nuclear Information System (INIS)

    Mckissock, B.I.; Bloomfield, H.S.

    1989-01-01

    Missions which use nuclear reactor power systems require radiation shielding of payload and/or crew areas to predetermined dose rates. Since shielding can become a significant fraction of the total mass of the system, it is of interest to show the effect of various parameters on shield thickness and mass for manned and unmanned applications. Algorithms were developed to give the thicknesses needed if reactor thermal power, separation distances, and dose rates are given as input. The thickness algorithms were combined with models for four different shield geometries to allow tradeoff studies of shield volume and mass for a variety of manned and unmanned missions. Shield design tradeoffs presented in this study include the effects of: higher allowable dose rates; radiation hardened electronics; shorter crew exposure times; shield geometry; distance of the payload and/or crew from the reactor; and changes in the size of the shielded area. Specific NASA missions that were considered in this study include unmanned outer planetary exploration, manned advanced/evolutionary space station, and advanced manned lunar base

  15. The Man Who Knew Infinity

    Indian Academy of Sciences (India)

    his work. Ramanujan did mathematics for its own sake, for the thrill that he got in seeing and discovering ... in those times led to a frantic search for a job to earn an income. .... mathematics, a man whose career seems full of paradoxes and ...

  16. [Albert Schweitzer. The man as a symbol].

    Science.gov (United States)

    Urdaneta-Carruyo, Eliexer

    2007-01-01

    Albert Schweitzer, the great missionary physician from the XXth century, had a versatile personality that integrated multiple talents, leading to the slightly frequent conjunction of the thinker with the man of action, and the humanist with the scientist and the artist. He studied all these disciplines in a brilliant manner: Philosophy, Theology, Music and Medicine; he was also a great scholar of Bach's work, Jesus Christ and the civilization history. In his maturity, this great man renounced to the fame and glory gained as intellectual and musician, to dedicate his life as a physician for the forgotten African natives. His deeply religious spirit allowed him to penetrate into the most recondite of the human soul; in his personality, he expressed in its entire dimension the eternally unsatisfied desire of the solitary man, against the immensity of the universe. His philosophy, based on the respect for life, was realized throughout the practice of the medical profession. His noble character and personality was based on the man as symbol, since it was not so much what he did helping people but what people could do to others due to him. His singular example represented a moral force in the world, superior to millions of men armed for a war. In 1953, he received the Nobel Peace Prize for his philanthropic work in Africa during more that fifty years, and for his deep love to the living beings. He was transformed in a perennial legend as the Lambaréné doctor.

  17. Benzodiazepine receptor binding in vivo with (/sup 3/)-Ro 15-1788

    Energy Technology Data Exchange (ETDEWEB)

    Goeders, N.E.; Kuhar, M.J.

    1985-07-29

    In vivo benzodiazepine receptor binding has generally been studied by ex vivo techniques. In this investigation, the authors identify the conditions where (/sup 3/H)-Ro 15-1788 labels benzodiazepine receptors by true in vivo binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. (/sup 3/H)-Flunitrazepam and (/sup 3/H)-clonazepam did not exhibit useful in vivo receptor binding. 39 references, 5 figures, 1 table.

  18. [A novel TaqMan® MGB probe for specifically detecting Streptococcus mutans].

    Science.gov (United States)

    Zheng, Hui; Lin, Jiu-Xiang; DU, Ning; Chen, Feng

    2013-10-18

    To design a new TaqMan® MGB probe for improving the specificity of Streptococcus mutans's detection. We extracted six DNA samples from different streptococcal strains for PCR reaction. Conventional nested PCR and TaqMan® MGB real-time PCR were applied independently. The first round of nested PCR was carried out with the bacterial universal primers, while a second PCR was conducted by using primers specific for the 16S rRNA gene of Streptococcus mutans. The TaqMan® MGB probe for Streptococcus mutans was designed from sequence analyses, and the primers were the same as nested PCR. Streptococcus mutans DNA with 2.5 mg/L was sequentially diluted at 5-fold intervals to 0.16 μg/L. Standard DNA samples were used to generate standard curves by TaqMan® MGB real-time PCR. In the nested PCR, the primers specific for Streptococcus mutans also detected Streptococcus gordonii with visible band of 282 bp, giving false-positive results. In the TaqMan® MGB real-time PCR reaction, only Streptococcus mutans was detected. The detection limitation of TaqMan® MGB real-time PCR for Streptococcus mutans 16S rRNA gene was 20 μg/L. We designed a new TaqMan® MGB probe, and successfully set up a PCR based method for detecting oral Streptococcus mutans. TaqMan® MGB real-time PCR is a both specific and sensitive bacterial detection method.

  19. Mass of organs and composition of the body of Japanese Reference Man

    International Nuclear Information System (INIS)

    Tanaka, Gi-ichiro

    1990-01-01

    Reference Man as defined and described in ICRP Publication 23 is in the process of major revision, with an emphasis on the age and sex, and characteristics of non-European populations. Japanese Reference Man (or Woman) is to be defined as the subject, normal and healthy, 20 to 30 years of age, who inhabits in Japan and live on the 'standard diet'. He (or she) is a Mongoloid in race, and 170 (or 160) cm in height, and 60 (or 51) kg in weight. Physical properties such as masses of 114 organs, tissues and components, and their specific gravities of Japanese Reference Male are given. Body composition or body fat, LBM, skeleton, soft lean body mass (SLBM), body water, blood, muscle, ash, protein and specific gravity were also given as well as body surface. These data are primarily based on the data obtained for normal Japanese, and, where data unavailable, they were derived from ICRP Reference Man data by using a new concept of SLBM. Red bone marrow was estimated to be 1,000g as compared to 1,500g in Reference Man. Body fat was obtained by using Nagamine's equations, which showed a recent slight tendency of obesity. In conclusion, the present data for Japanese Reference Man could be used in designing appropriate phantoms, mathematical and real, for Japanese. Japanese Reference Man will also provide a basis for Asian Reference Man, which, in principle, should be consistent with ICRP concepts of Reference Man. (author)

  20. Review of serious events in cases of (suspected) child abuse and/or neglect: A RoSE by any other name?

    Science.gov (United States)

    Raman, Shanti; Maiese, Michelle; Vasquez, Viviana; Gordon, Paola; Jones, Jennifer M

    2017-08-01

    Child abuse and neglect (CAN) cases presenting to health-services may be complex; when things go seriously wrong such as a child death or near miss, cases are reviewed and health-services and professionals subject to intense scrutiny. While there are a variety of mechanisms to review critical incidents in health-services no formal process for the review of cases where child protection is the primary concern exists in Australia. We aimed to develop a systematic process to review serious events in cases of suspected CAN across two health districts in Sydney, so that shared learnings could fuel system change. Drawing upon mapping, case review, literature findings and using quality improvement methodology, we developed a model named Review of Serious Events (RoSE), in suspected cases of CAN. The RoSE model has the key features of: being child focused; seeking to examine care over a period of time; using child protection staff as lead reviewers; involving health professionals/services in the review who have been involved with the child; and actioning systems change at local levels. The RoSE model was trialled through 2014-2015. Eight cases were reviewed using RoSE; cases were similar to those reviewed prior to having a model. Participant feedback from RoSE group processes was overwhelmingly positive; outputs were transparent and accessible to key stakeholders, there was mixed progress with implementation. The RoSE model is a serious case review process that is strongly child-focused, is both investigative and reflective, led by child protection experts; and can be adapted to other settings and systems. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  1. The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

    Directory of Open Access Journals (Sweden)

    Bateman Alex

    2003-10-01

    Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

  2. [Man's place and anthropology in bioethics].

    Science.gov (United States)

    Tomar Romero, Francisca

    2013-01-01

    From the analysis of its epistemological status, the article focuses on the philosophical fundament of bioethics, stressing the need for an authentic anthropology as a reference or starting point. Being an applied ethics, the first fundament of bioethics is in ethics. It shows how only personalistic ethics, which takes as reference the nature or essence of man, can offer objective and universal criteria. Philosophical anthropology studies man as a whole, in an integral manner, from the perspective of its nature or fundamental aspects of his being. It analyzes the distinction and relationship between the philosophical anthropology and the positive anthropologies, as well as with the physical, human and social sciences. Finally, it reflects on the current anthropological crisis and its ethical consequences.

  3. Recent developments in man-machine systems

    International Nuclear Information System (INIS)

    Johannsen, G.

    1987-01-01

    The field of man-machine systems is introduced with its subareas and a short outline of its history of 45 years. Three current lines of development in university and industrial research are emphasized. Today, the human problem solving activities are experimentally investigated and analytically described more vigorously than the control activities. Further, improved information presentations and decision support are made possible through new technologies of computer graphics and expert systems. At last, work on a general design methodology for man-machine systems is in progress. The aim is to better support human operators of dynamic technological systems as well as designers of graphics for visual display units and of dialogue styles. Thereby, safety and availability of the complete system can be increased. (orig.) [de

  4. Quantum Man: Richard Feynman's Life in Science

    CERN Document Server

    CERN. Geneva

    2011-01-01

    It took a man who was willing to break all the rules to tame a theory that breaks all the rules. This talk will be based on my new book Quantum Man: Richard Feynman's life in science. I will try and present a scientific overview of the contributions of Richard Feynman, as seen through the arc of his fascinating life. From Quantum Mechanics to Antiparticles, from Rio de Janeiro to Los Alamos, a whirlwind tour will provide insights into the character, life and accomplishments of one of the 20th centuries most important scientists, and provide an object lesson in scientific integrity.

  5. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. YONG J IANG. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1255-1261. Molecular dynamics study on the relaxation properties of bilayered graphene with defects · WEI ZHANG JIU-REN YIN PING ZHANG YAN-HUAI DING YONG J IANG.

  6. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Abandon ship and man overboard drills and training. 185... VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man... the water as if during an actual man overboard situation: (1) Once each month, if reasonable and...

  7. 123I-labeling and evaluation of Ro 43-0463, a SPET tracer for MAO-B imaging

    International Nuclear Information System (INIS)

    Beer, H.-F.; Rossetti, I.; Frey, L.D.; Hasler, P.H.; Schubiger, P.A.

    1995-01-01

    Using the copper assisted halogen exchange the MAO-B inhibitor Ro 43-0463, N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide, was labelled with 123 I as well as with 125 I to allow in vitro and in vivo investigations including SPET with healthy volunteers. Ro 43-0463 is known to inhibit reversibly and specifically MAO-B, having an ic 50 of 3 x 10 -8 Mol/L. The labeling in the presence of CuSO 4 and ascorbic acid was optimised, varying time (30 to 105 min), precursor concentration (1-3.5 mg) and temperature (130-200 deg. C). The labeling yield ranged between 60 and 70%. Purification was achieved with Lichrosorb RP-18 (5 μm, 250 x 8 mm) and 1.5 mL/min 0.36 M H 3 PO 4 /EtOH (97(3)) [0.01 M (NH 4 ) 2 HPO 4 ]. After neutralisation and sterile filtration the final activity concentration ranged between 18.5 and 37 MBq/mL. Biodistribution studies showed a brain to blood ratio greater than 1 within 1 h p.i. The main radiation burden calculated from these animal data is to alimentary and excretory organs and the ovaries. Autoradiography was performed using rat brain slices and 5 nM [ 125 I]Ro 43-0463 in TRIS-buffer pH 7.4 for 90 min at 20 deg. C. Its radioactivity pattern corresponds to the known distribution of MAO-B in the rat brain. By displacement with L-deprenyl the highly specific binding of Ro 43-0463 was proven in vitro. SPECT studies with normal volunteers corresponded with the pattern found in autoradiography

  8. An Intercomparison of GPS RO Retrievals with Colocated Analysis and In Situ Observations within Tropical Cyclones

    Directory of Open Access Journals (Sweden)

    Henry R. Winterbottom

    2010-01-01

    Full Text Available Observations from four Global Position System (GPS Radio Occultation (RO missions: Global Positioning System/Meteorology, CHAallenging Minisatellite Payload, Satellite de Aplicaciones Cientificas-C, and Constellation Observing System for Meteorology, Ionosphere and Climate and Taiwan's FORMOsa SATellite Mission #3 (COSMIC/FORMOSAT-3 are collected within a 600 km radius and ±180 minute temporal window of all observed tropical cyclones (TCs from 1995 to 2006 that were recorded in the global hurricane best-track reanalysis data set (Jarvinen et al. (1984; Davis et al. (1984. A composite analysis of tropical cyclone radial mean temperature and water vapor profiles is carried out using the GPS RO retrievals which are colocated with global analysis profiles and available in situ radiosonde observations. The differences between the respective observations and analysis profiles are quantified and the preliminary results show that the observations collected within TCs correspond favorably with both the analysis and radiosonde profiles which are colocated. It is concluded that GPS RO observations will contribute significantly to the understanding and modeling of TC structures, especially those related to vertical variability of the atmospheric state within TCs.

  9. Propulsive options for a manned Mars transportation system

    International Nuclear Information System (INIS)

    Braun, R.D.; Blersch, D.J.

    1989-01-01

    In this investigation, five potential manned Mars transportation systems are compared. These options include: (1) a single vehicle, chemically propelled (CHEM) option, (2) a single vehicle, nuclear thermal propulsion (NTP) option, (3) a single vehicle solar electric propulsion (SEP) option, (4) a single vehicle hybrid nuclear electric propulsion (NEP)/CHEM option, and (5) a dual vehicle option (NEP cargo spacecraft and CHEM manned vehicle). In addition to utilizing the initial vehicle weight in low-earth orbit as a measure of mission feasibility, this study addresses the major technological barriers each propulsive scenario must surpass. It is shown that instead of a single clearly superior propulsion system, each means of propulsion may be favored depending upon the specified program policy and the extent of the desired manned flight time. Furthermore, the effect which aerobraking and multiple transfer cycles have upon mission feasibility is considered. 18 refs

  10. Multimedia Discovery of the Leonardo’s Vitruvian Man

    Directory of Open Access Journals (Sweden)

    Eva Savina Maliverni

    2015-07-01

    Full Text Available The dissemination and exploitation of cultural heritage milestones by using multimedia and interactive technologies continuously and quickly grows capturing the attention of academia and companies. It is necessary to adopt the state of the art technologies to present and make bi-directional the interaction of users with cultural heritage objects. In this work, we present two different applications of novel technologies applied to the Vitruvian man of Leonardo. The first application is the mirror that exploits a 3D depth sensor to compare the proportions of a user with the perfect ones of the Vitruvian man. The second application is a complex interaction between a complete novel 3D model of the Leonardo’s Vitruvian Man, sounds and image effects inside a 360-degrees hologram. These two systems are the results of interaction between academia and the 3D EVE spin-off company.

  11. Thoughts on the cultural evolution of man. Developmental imprinting and transgenerational effect.

    Science.gov (United States)

    Csaba, György

    2007-01-01

    The biological evolution of man stopped since it has been conveyed to the objects, created by man. This paper introduces the concept of "conveyed evolution". Being part of the cultural evolution, the conveyed evolution is a continuation of the biological one. There are several similarities between the laws of biological and conveyed evolution, albeit the differences are important as well. Some laws of the conveyed evolution are described here. The conveyed evolution has man-made repair mechanisms (medicine, protection of environment) which defend man from harm. Man's fragility limits the progress of conveyed evolution. However, artificial compounds or environmental pollutants which are provoked by the conveyed evolution induce chemical (hormonal) imprinting in the developmental critical periods, which is transmitted to the progeny generations (transgenerational effect). This could cause evolutionary alterations without mutation.

  12. Adaptive Training and Collective Decision Support Based on Man-Machine Interface

    Science.gov (United States)

    2016-03-02

    Based on Man -machine Interface The views, opinions and/or findings contained in this report are those of the author(s) and should not contrued as an...ADDRESS (ES) U.S. Army Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 adaptive training, EEG, man -machine interface...non peer-reviewed journals: Final Report: Adaptive Training and Collective Decision Support Based on Man -machine Interface Report Title The existence of

  13. Man, Satan, and God of Mawlana (Rumi and Milton

    Directory of Open Access Journals (Sweden)

    Leila Mir Mojarabian

    Full Text Available This research is a critical analysis on the place of human and his integration with religious issues, and the subject of disobedience and rebellion. In addition, topics such as reward, punishment, redemption and salvation of mankind in two great works of literature of the world, Masnavi by Mawlana and Paradise Lost by Milton have been comparatively discussed. Rumi's poetry and thought has been accepted by commons and special people in Iran and the world. Rumi is one of the few supreme poets in Persian language and the world. Generally, Milton has Known as the greatest English poet after Shakespeare, and his Paradise Lost as the greatest English fiction poem. This work is a the well-known epics of human-divine composed in live new languages, and comparing these two works even in one field of speech, indeed is the comparison of two thoughts, two nations, and two ancient cultures. The author attempts to examine the similarities and contrasts of the two poems of these two great poets on the subjects of human, God, and Satan and the world, to achieve the analytical and critical comparison of them in this context. In this paper the author tries to base the Paradise Lost of Milton and compare it with the ideas of Mawlana common to imagine man's first story and his disobedience, religious approaches, and finally the end presumed for mankind. In these two poems, contrast between "God" and "man" is derived from the fundamental relationship between "God" and "man". Milton while calls God, our Heavenly Father and refer to his role of creativity, entitles him as the dominant power, All mighty, the victorious winner, Glorious and Holy ruler, powerful king, and in one word, omnipotent. The Creator that all creatures are worshiping him, the omnipotent could be seen his capability remarks in everywhere, the unique structure of the universe beautiful is his own and the glorious ruler, sitting over the skies, sometimes invisible and sometimes visible, even

  14. 46 CFR 122.520 - Abandon ship and man overboard drills and training.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Abandon ship and man overboard drills and training. 122... OPERATIONS Preparations for Emergencies § 122.520 Abandon ship and man overboard drills and training. (a) The... launched with its assigned crew aboard and maneuvered in the water as if during the actual man overboard...

  15. Don't Trust the Big Man

    National Research Council Canada - National Science Library

    Coerr, Stanton S

    2008-01-01

    .... A full-length analysis of the Democratic Republic of the Congo and its full-scale insurgencies since 1960 -- at the hands of Big Man leaders Lumumba, Mobutu, and Kabila -- provide object lessons...

  16. Effective selection of transgenic papaya plants with the PMI/Man selection system.

    Science.gov (United States)

    Zhu, Yun J; Agbayani, Ricelle; McCafferty, Heather; Albert, Henrik H; Moore, Paul H

    2005-09-01

    The selectable marker gene phospho-mannose isomerase (pmi), which encodes the enzyme phospho-mannose isomerase (PMI) to enable selection of transformed cell lines on media containing mannose (Man), was evaluated for genetic transformation of papaya (Carica papaya L.). We found that papaya embryogenic calli have little or no PMI activity and cannot utilize Man as a carbon source; however, when calli were transformed with a pmi gene, the PMI activity was greatly increased and they could utilize Man as efficiently as sucrose. Plants regenerated from selected callus lines also exhibited PMI activity but at a lower specific activity level. Our transformation efficiency with Man selection was higher than that reported using antibiotic selection or with a visual marker. For papaya, the PMI/Man selection system for producing transgenic plants is a highly efficient addition to previously published methods for selection and may facilitate the stacking of multiple transgenes of interest. Additionally, since the PMI/Man selection system does not involve antibiotic or herbicide resistance genes, its use might reduce environmental concerns about the potential flow of those genes into related plant populations.

  17. An Automated Planning Model for RoF Heterogeneous Wireless Networks

    DEFF Research Database (Denmark)

    Shawky, Ahmed; Bergheim, Hans; Ragnarsson, Ólafur

    2010-01-01

    The number of users in wireless WANs is increasing like never before, at the same time as the bandwidth demands by users increase.The structure of the third generation Wireless WANs makes it expensive for Wireless ISPs to meet these demands.The FUTON architecture is a RoF heterogeneous wireless...... network architecture under development,that will be cheaper to deploy and operate.This paper shows a method to plan an implementation of this architecture.The planning is done as automatic as possible,covering radio planning, fiber planning and network dimensioning. The out come of the paper is a planning...

  18. Agricultural measures to reduce radiation doses to man caused by severe nuclear accidents

    International Nuclear Information System (INIS)

    Dorp, F. van; Eleveld, R.; Frissel, M.J.

    1981-01-01

    Agricultural land and products may become contaminated after a severe nuclear accident. If radiation doses to man caused by the ingestion of contaminated agricultural products from such areas will be unacceptably high, measures to reduce this radiation dose will have to be taken. Radiation doses to man can be estimated by using models which describe quantitatively the transfer of radionuclides through the biosphere. The following processes and pathways are described in this study: accidental releases into atmospheric environments and subsequent nearby deposition; contamination of crops by direct deposition and the subsequent short term pathway (e.g. grass-cow-milk-man); contamination of soil and the subsequent long term pathway (e.g. soil-crop-man, soil-grass-cattle-milk/meat-man). Depending on the degree of contamination and on the estimated radiation doses to man, various measures are advised. (Auth.)

  19. Man-machine supervision; Supervision homme-machine

    Energy Technology Data Exchange (ETDEWEB)

    Montmain, J. [CEA Valrho, Dir. de l' Energie Nucleaire (DEN), 30 - Marcoule (France)

    2005-05-01

    Today's complexity of systems where man is involved has led to the development of more and more sophisticated information processing systems where decision making has become more and more difficult. The operator task has moved from operation to supervision and the production tool has become indissociable from its numerical instrumentation and control system. The integration of more and more numerous and sophisticated control indicators in the control room does not necessary fulfill the expectations of the operation team. It is preferable to develop cooperative information systems which are real situation understanding aids. The stake is not the automation of operators' cognitive tasks but the supply of a reasoning help. One of the challenges of interactive information systems is the selection, organisation and dynamical display of information. The efficiency of the whole man-machine system depends on the communication interface efficiency. This article presents the principles and specificities of man-machine supervision systems: 1 - principle: operator's role in control room, operator and automation, monitoring and diagnosis, characteristics of useful models for supervision; 2 - qualitative reasoning: origin, trends, evolutions; 3 - causal reasoning: causality, causal graph representation, causal and diagnostic graph; 4 - multi-points of view reasoning: multi flow modeling method, Sagace method; 5 - approximate reasoning: the symbolic numerical interface, the multi-criteria decision; 6 - example of application: supervision in a spent-fuel reprocessing facility. (J.S.)

  20. Heidegger: Sense-Nonsense Dualism of Man in Technology Dimensions

    Directory of Open Access Journals (Sweden)

    Nathalia Andrea Álvarez

    2008-12-01

    Full Text Available This article tries to analyze the ontological-existential compromise that man acquires when using new technologies, in the light of theHeideggerian’ proposal. This compromise means, on the one hand, theresponsibility of forgetting the self in technology, which immerses man in a non-sense; and on the other, the will to open himself to the recognition of the ways in which his “being-in-the-world” manifests. To this end, the perils of technological “instrumentalization” will be presented, based upon the Heideggerian explanation about the essence of technology. We will present the Heideggerian concepts of anxiety1 and nothingness concepts, with which we will try to conduct the postmodern man towards the encounter with his original sense.

  1. A 0.8-2.4 μm Transmission spectrum of the hot Jupiter CoRoT-1b

    Energy Technology Data Exchange (ETDEWEB)

    Schlawin, E.; Herter, T. [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States); Zhao, M. [Department of Astronomy, Pennsylvania State University, University Park, PA 16802 (United States); Teske, J. K. [Astronomy Department, The University of Arizona, Tucson, AZ 85721 (United States)

    2014-03-01

    Hot Jupiters with brightness temperatures ≳2000 K can have TiO and VO molecules as gaseous species in their atmospheres. The TiO and VO molecules can potentially induce temperature inversions in hot Jupiter atmospheres and also have an observable signature of large optical to infrared transit depth ratios. Previous transmission spectra of very hot Jupiters have shown a lack of TiO and VO, but only in planets that also appear to lack temperature inversions. We measure the transmission spectrum of CoRoT-1b, a hot Jupiter that was predicted to have a temperature inversion potentially due to significant TiO and VO in its atmosphere. We employ the multi-object spectroscopy method using the SpeX and MORIS instruments on the Infrared Telescope Facility (IRTF) and the Gaussian process method to model red noise. By using a simultaneous reference star on the slit for calibration and a wide slit to minimize slit losses, we achieve transit depth precision of 0.03%-0.09%, comparable to the atmospheric scale height but detect no statistically significant molecular features. We combine our IRTF data with optical CoRoT transmission measurements to search for differences in the optical and near-infrared absorption that would arise from TiO/VO. Our IRTF spectrum and the CoRoT photometry disfavor a TiO/VO-rich spectrum for CoRoT-1b, suggesting that the atmosphere has another absorber that could create a temperature inversion or that the blackbody-like emission from the planet is due to a spectroscopically flat cloud, dust, or haze layer that smoothes out molecular features in both CoRoT-1b's emission and transmission spectra. This system represents the faintest planet hosting star (K = 12.2) with a measured planetary transmission spectrum.

  2. Queer encounters between Iron Man and Chinese boys' love fandom

    Directory of Open Access Journals (Sweden)

    John Wei

    2014-09-01

    Full Text Available Superhero fan fiction is increasingly popular in the Chinese boys' love (BL community. An exploration of the fan fic Gangtiexia: Zhongdu Yilai (Iron Man: Overly attached investigates how the Hollywood cultural icon Iron Man/Tony Stark is reimagined in Chinese BL culture and to what degree this kind of rendition both echoes and extends as well as challenges and deviates from our current insights into BL fandoms. Through the lenses of queerness and technological human transformation, I explore the fresh contribution of Iron Man fan fiction to both local BL cultures and global superhero fandoms.

  3. Food concentrations and dietary intakes of elements for Chinese man

    International Nuclear Information System (INIS)

    Zhu Hongda; Wang Jixian; Chen Rusong

    2000-01-01

    Objective: To obtain concentrations of elements in Chinese current foods and their dietary intakes by adult man in order to provide a basis on intake parameters of Chinese Reference Man and make related hygienic evaluation. Methods: With mixed food sample method of total diet study, determination of element concentrations in constituent foods of diets for 4 areas with different diet types was carried out by using NAA, ICP-MS, ICP-AES, AAS and necessary QA measures, and estimation of their daily intakes and hygienic evaluation were also made. Results: The concentrations of 42 elements in 12 categories of foods, their intakes and hygienic evaluation for adult man were obtained. Conclusion: The data on element concentrations in Chinese foods and their dietary intakes were updated and widened. These data provided a new basis for developing the parameters of Chinese Reference Man and revealed some current hygienic problems. For example, from viewpoint of nutrition hygiene the Ca, Zn, and Cu intakes for Chinese Reference Man are insufficient, and from consideration of food hygiene the intakes of Pb,Cd and Na are excessive.. Especially, and Cd average daily intakes of Pb, Cd and Hg have been increased during recent years, those of Pb exceed their ADIs, which should be paid attention to

  4. Environmental Education: The Whole Man Revisited

    Science.gov (United States)

    Kormondy, Edward J.

    1971-01-01

    Environmental education is seen as an interdisciplinary study of the ecology of man, viewed in his totality, in all his dimensions. Biology is not considered the central discipline in this study. (Author/AL)

  5. Inhibitory Effects of Cytosolic Ca2+ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets

    Directory of Open Access Journals (Sweden)

    Hyuk-Woo Kwon

    2015-01-01

    Full Text Available Intracellular Ca2+ ([Ca2+]i is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca2+-antagonistic effect of ginsenoside Ro (G-Ro, an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca2+]i, which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI (Ser1756 to inhibit [Ca2+]i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser1756 by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa, indicating inhibition of Ca2+ influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP3RI (Ser1756 phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa to decrease thrombin-elevated [Ca2+]i, which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca2+-antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease.

  6. Man, Controller of the Universe

    Science.gov (United States)

    Olowin, R. P.

    2011-06-01

    The Man, Controller of the Universe painted by the renowned Mexican artist Diego Rivera in the gigantic mural of the Palace of Fine Arts in Mexico City is overlooked by a telescope. We acknowledge this instrument as the Plaskett Telescope at the Dominion Astrophysical Observatory in Victoria, Canada.

  7. North Korean Civil-Military Trends: Military-First Politics to a Point

    Science.gov (United States)

    2006-09-01

    to the Great Leader. Yi Yong Mu. The NDC’s impact on the formal leadership lineup was made clear by 2001, when Yi Yong Mu, vice chairman of the NDC...to be restricted, as are career bonds that could come about between officers through sequential appointments to same commands. • First time

  8. RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

    Science.gov (United States)

    Movahedi, Kiavash; Wiegmann, Robert; De Vlaminck, Karen; Van Ginderachter, Jo A; Nikolaev, Viacheslav O

    2018-07-01

    Functional mosaic analysis allows for the direct comparison of mutant cells with differentially marked control cells in the same organism. While this offers a powerful approach for elucidating the role of specific genes or signalling pathways in cell populations of interest, genetic strategies for generating functional mosaicism remain challenging. We describe a novel and streamlined approach for functional mosaic analysis, which combines stochastic Cre/lox recombination with gene targeting in the ROSA26 locus. With the RoMo strategy a cell population of interest is randomly split into a cyan fluorescent and red fluorescent subset, of which the latter overexpresses a chosen transgene. To integrate this approach into high-throughput gene targeting initiatives, we developed a procedure that utilizes Gateway cloning for the generation of new targeting vectors. RoMo can be used for gain-of-function experiments or for altering signaling pathways in a mosaic fashion. To demonstrate this, we developed RoMo-dnGs mice, in which Cre-recombined red fluorescent cells co-express a dominant-negative Gs protein. RoMo-dnGs mice allowed us to inhibit G protein-coupled receptor activation in a fraction of cells, which could then be directly compared to differentially marked control cells in the same animal. We demonstrate how RoMo-dnGs mice can be used to obtain mosaicism in the brain and in peripheral organs for various cell types. RoMo offers an efficient new approach for functional mosaic analysis that extends the current toolbox and may reveal important new insights into in vivo gene function. © 2018 Wiley Periodicals, Inc.

  9. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    Science.gov (United States)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  10. Manned Mars mission communication and data management systems

    Science.gov (United States)

    White, Ronald E.

    1986-01-01

    A manned Mars mission will involve a small crew and many complex tasks. The productivity of the crew and the entire mission will depend significantly on effective automation of these tasks and the ease with which the crew can interface with them. The technology to support a manned Mars mission is available today; however, evolving software and electronic technology are enabling many interesting possibilities for increasing productivity and safety while reducing life cycle cost. Some of these advanced technologies are identified.

  11. Time and man

    CERN Document Server

    Elton, L. R. B

    1978-01-01

    Time and Man focuses on the endeavors of humans to probe the mysteries of time and to elucidate its properties. The discussions are both philosophical and factual in nature and encompass science as well as the physical sciences, biology and related disciplines (for example, evolution), and the humanities (for example, religion). Factual information is presented to help the reader gain a better understanding of the concepts associated with time.Comprised of nine chapters, this volume first considers the passage of time and the experiences which humans associate with the concept of time before r

  12. Three-gradual pilot unit of JP3RO for cleanings and concentration of radioactive sewage by method of upturned osmosis

    International Nuclear Information System (INIS)

    Chmielewski, A.G.; Harasimowicz, M.; Tyminski, B.; Zakrzewska-Trznadel, G.

    2001-01-01

    For many years the Institute of Nuclear Chemistry and Technology has worked on the application of different membrane processes to nuclear technology. The experiments with ultrafiltration, ultrafiltration combined with chemical complexation, membrane distillation and reverse osmosis were conducted. Reverse osmosis (RO) as a method for liquid radioactive waste treatment has been examined at laboratory and pilot plant installations. Thr purification of radioactive model solutions as well as liquid low and medium level radioactive waste samples has been examined with various reverse osmotic modules equipped with thin composite polymeric membranes. The experience with the process led to design and construction of the JP3RO industrial plant, 1 m 3 capacity, composed of three RO stages. On the basis of earlier investigations, membrane modules were selected for the plant. The installation is described in this paper, and the results of experiments are presented. The JP3RO installation was included into the system of liquid low and medium-level radioactive wastes treatment at Institute of Nuclear Energy in Swierk. (author)

  13. Man-Robot Symbiosis: A Framework For Cooperative Intelligence And Control

    Science.gov (United States)

    Parker, Lynne E.; Pin, Francois G.

    1988-10-01

    The man-robot symbiosis concept has the fundamental objective of bridging the gap between fully human-controlled and fully autonomous systems to achieve true man-robot cooperative control and intelligence. Such a system would allow improved speed, accuracy, and efficiency of task execution, while retaining the man in the loop for innovative reasoning and decision-making. The symbiont would have capabilities for supervised and unsupervised learning, allowing an increase of expertise in a wide task domain. This paper describes a robotic system architecture facilitating the symbiotic integration of teleoperative and automated modes of task execution. The architecture reflects a unique blend of many disciplines of artificial intelligence into a working system, including job or mission planning, dynamic task allocation, man-robot communication, automated monitoring, and machine learning. These disciplines are embodied in five major components of the symbiotic framework: the Job Planner, the Dynamic Task Allocator, the Presenter/Interpreter, the Automated Monitor, and the Learning System.

  14. The effects of ionizing radiation on man

    International Nuclear Information System (INIS)

    Watson, G.M.

    1975-08-01

    This paper describes the major effects of ionizing radiation on man and the relationship between such effects and radiation dose, with the conclusion that standards of radiological safety must be based on the carcinogenetic and mutagenic properties of ionizing radiation. Man is exposed to radiation from natural sources and from man-made sources. Exposure from the latter should be regulated but, since there is little observational or experimental evidence for predicting the effects of the very small doses likely to be required for adequate standards of safety, it is necessary to infer them from what is seen at high doses. Because the formal relationship between dose and effect is not fully understood, simplifying assumptions are necessary to estimate the effects of low doses. Two such assumptions are conventionally used; that there is a linear relationship between dose and effect at all levels of dose, and that the rate at which a dose of radiation is given does not alter the magnitude of the effect. These assumptions are thought to be conservative, that is they will not lead to an underestimation of the effects of small radiation doses although they may give an over-estimate. (author)

  15. Symmetry-Adapted Ro-vibrational Basis Functions for Variational Nuclear Motion Calculations: TROVE Approach.

    Science.gov (United States)

    Yurchenko, Sergei N; Yachmenev, Andrey; Ovsyannikov, Roman I

    2017-09-12

    We present a general, numerically motivated approach to the construction of symmetry-adapted basis functions for solving ro-vibrational Schrödinger equations. The approach is based on the property of the Hamiltonian operator to commute with the complete set of symmetry operators and, hence, to reflect the symmetry of the system. The symmetry-adapted ro-vibrational basis set is constructed numerically by solving a set of reduced vibrational eigenvalue problems. In order to assign the irreducible representations associated with these eigenfunctions, their symmetry properties are probed on a grid of molecular geometries with the corresponding symmetry operations. The transformation matrices are reconstructed by solving overdetermined systems of linear equations related to the transformation properties of the corresponding wave functions on the grid. Our method is implemented in the variational approach TROVE and has been successfully applied to many problems covering the most important molecular symmetry groups. Several examples are used to illustrate the procedure, which can be easily applied to different types of coordinates, basis sets, and molecular systems.

  16. Hvad er inklusion, og hvordan leder man det?

    DEFF Research Database (Denmark)

    Næsby, Torben; Qvortrup, Lars

    2014-01-01

    En fundamental forudsætning for at inklusion både kan gøres til et centralt tema og at medarbejdernes kompetencer kan styrkes, er, at alle medarbejdere ved, hvad man snakker om, og at man har en fælles, operationaliserbar forståelse af, hvad inklusion er. Der skal formuleres en definition af...... definition, som både er bredt, præcist og operationaliserbart. Derefter fremlægges forslag til, hvad man kan gøre som ledelse for at få inklusionsindsatsen til at lykkes....... inklusion i det enkelte dagtilbud, der både kan anerkendes af alle, så den gøres til et fælles anliggende, og kan operationaliseres, så alle kan se, hvad de skal gøre for at få indsatsen til at lykkes. Artiklen indledes med at diskutere de gængse definitioner af inklusion og præsentere et nyt forslag til en...

  17. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.

    Science.gov (United States)

    Bermeo, Sandra; Al-Saedi, Ahmed; Kassem, Moustapha; Vidal, Christopher; Duque, Gustavo

    2017-12-01

    Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. In contrast, osteogenesis remained stable upon MAN1 overexpression. Regarding a mechanism, we found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads-related complexes, with a concurrently high expression of nuclear β-Catenin. In addition, we found adipogenesis to be decreased in both conditions, although predominantly affected by MAN1 overexpression. Finally, lamin A, a protein of the nuclear envelope that regulates MSC differentiation, was unaffected by changes in MAN1. In conclusion, our studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis. These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425-4435, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  18. Man-mashine communication improvements in computerized operator support system by new technologies

    International Nuclear Information System (INIS)

    Tai, I.; Seki, E.; Fukumoto, A.; Mori, N.; Tsuchida, M.; Itoh, J.; Tanaka, K.

    1984-01-01

    Improvement of the man-machine interface performance is under way as Computerized Operator Support System for nuclear power plants in Japan. This paper describes several improved points in the design of man-mashine interface, especially on the console, based on the evaluation of the conventional design and by taking into account the performance test results of new man-machine interfacing tools. (author)

  19. Man and radiation effects

    International Nuclear Information System (INIS)

    Rausch, L.

    1982-01-01

    The book describes the effects of ionizing radiation on man in a simple, popular, detailed and generally valid manner and gives a comprehensive picture of the concepts, elements, principles of function, and perspectives of medical radiobiology. Radiobiology in general is explained, and its application in research on the causes of radiolesions and radiation diseases as well as a radiotherapy and radiation protection is discussed in popular form. (orig./MG) [de

  20. Estimate of man-rem expenditures for a mature CANDU 600 MW(e) station

    International Nuclear Information System (INIS)

    Kuperman, I.

    1978-08-01

    In recent years, man-rem expenditures at operating stations have come under close scrutiny in order to reduce operating personnel dosage. This increased awareness has led to concerted efforts to improve station design and to improve operating procedures to achieve lower man-rem expenditures. This paper is intended to highlight design improvements that have been made in the CANDU 600 MW(e) design and to show how these improvements will reduce man-rem expenditures. Other considerations, such as station decontaminations of the primary heat transport system and the fuelling machines and stricter chemistry control are presently available to help reduce man-rem consumption. Also, station management operating policy should emphasize man-rem awareness. (author)

  1. New global electron density observations from GPS-RO in the D- and E-Region ionosphere

    Science.gov (United States)

    Wu, Dong L.

    2018-06-01

    A novel retrieval technique is developed for electron density (Ne) in the D- and E-region (80-120 km) using the high-quality 50-Hz GPS radio occultation (GPS-RO) phase measurements. The new algorithm assumes a slow, linear variation in the F-region background when the GPS-RO passes through the D- and E-region, and extracts the Ne profiles at 80-130 km from the phase advance signal caused by Ne. Unlike the conventional Abel function, the new approach produces a sharp Ne weighting function in the lower ionosphere, and the Ne retrievals are in good agreement with the IRI (International Reference Ionosphere) model in terms of monthly maps, zonal means and diurnal variations. The daytime GPS-RO Ne profiles can be well characterized by the α-Chapman function of three parameters (NmE, hmE and H), showing that the bottom of E-region is deepening and sharpening towards the summer pole. At high latitudes the monthly GPS-RO Ne maps at 80-120 km reveal clear enhancement in the auroral zones, more prominent at night, as a result of energetic electron precipitation (EEP) from the outer radiation belt. The D-/E-region auroral Ne is strongly correlated with Kp on a daily basis. The new Ne data allow further comprehensive analyses of the sporadic E (Es) phenomena in connection with the background Ne in the E-region. The layered (2-10 km) and fluctuated (Layer than Ne_Pert, are extracted with respect to the background Ne_Region on a profile-by-profile basis. The Ne_Layer component has a strong but highly-refined peak at ∼105 km, with an amplitude smaller than Ne_Region approximately by an order of magnitude. The Ne_Pert component, which was studied extensively in the past, is ∼2 orders of magnitude weaker than Ne_Layer. Both Ne_Layer and Ne_Pert are subject to significant diurnal and semidiurnal variations, showing downward progression with local time in amplitude. The 11-year solar cycle dominates the Ne interannual variations, showing larger Ne_Region and Ne_Layer but smaller

  2. Engineering the yeast Yarrowia lipolytica for the production of therapeutic proteins homogeneously glycosylated with Man8GlcNAc2 and Man5GlcNAc2

    Directory of Open Access Journals (Sweden)

    De Pourcq Karen

    2012-05-01

    Full Text Available Abstract Background Protein-based therapeutics represent the fastest growing class of compounds in the pharmaceutical industry. This has created an increasing demand for powerful expression systems. Yeast systems are widely used, convenient and cost-effective. Yarrowia lipolytica is a suitable host that is generally regarded as safe (GRAS. Yeasts, however, modify their glycoproteins with heterogeneous glycans containing mainly mannoses, which complicates downstream processing and often interferes with protein function in man. Our aim was to glyco-engineer Y. lipolytica to abolish the heterogeneous, yeast-specific glycosylation and to obtain homogeneous human high-mannose type glycosylation. Results We engineered Y. lipolytica to produce homogeneous human-type terminal-mannose glycosylated proteins, i.e. glycosylated with Man8GlcNAc2 or Man5GlcNAc2. First, we inactivated the yeast-specific Golgi α-1,6-mannosyltransferases YlOch1p and YlMnn9p; the former inactivation yielded a strain producing homogeneous Man8GlcNAc2 glycoproteins. We tested this strain by expressing glucocerebrosidase and found that the hypermannosylation-related heterogeneity was eliminated. Furthermore, detailed analysis of N-glycans showed that YlOch1p and YlMnn9p, despite some initial uncertainty about their function, are most likely the α-1,6-mannosyltransferases responsible for the addition of the first and second mannose residue, respectively, to the glycan backbone. Second, introduction of an ER-retained α-1,2-mannosidase yielded a strain producing proteins homogeneously glycosylated with Man5GlcNAc2. The use of the endogenous LIP2pre signal sequence and codon optimization greatly improved the efficiency of this enzyme. Conclusions We generated a Y. lipolytica expression platform for the production of heterologous glycoproteins that are homogenously glycosylated with either Man8GlcNAc2 or Man5GlcNAc2 N-glycans. This platform expands the utility of Y. lipolytica as a

  3. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. ZI-JING ZHANG. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ...

  4. FROM PONDS TO MAN-MADE SEAS IN RUSSIA

    Directory of Open Access Journals (Sweden)

    Sergey Gorshkov

    2013-01-01

    Full Text Available Russia has more than 2200 reservoirs and large ponds. As time went by, ponds lost their importance in some aspects of human life, while newly created man-made seas impacted the nature and the people in two ways. The costs involved in designing, constructing, and operating the artificial seas, especially on the plains, have been too high to consider them as an undisputed achievement of the Soviet scientists transforming the nature. This paper discusses the problem of ponds and man-made seas in Russia.

  5. Kant's answer to the question 'what is man?' and its implications for anthropology.

    Science.gov (United States)

    Cohen, Alix A

    2008-12-01

    This paper examines Kant's anthropological project and its relationship to his conception of 'man' in order to show that Kant's answer to the question 'what is man?' entails a decisive re-evaluation of traditional conceptions of human nature. I argue that Kant redirects the question 'what is man?' away from defining man in terms of what he is, and towards defining him in terms of what he does, in particular through the distinction between three levels of what I will call 'man's praxis': the levels of technicality, prudence, and morality. As soon as man is understood in terms of what he makes of himself rather than in terms of what he is, two crucial issues arise: what is the purpose of his making? And how can he reach this destination? My claim is that whilst the first question is answered by ethics and a doctrine of prudence, the second question is answered by anthropology. In this sense, anthropology plays the crucial role of identifying the worldly helps and hindrances to the realisation of man's purposes--and this is the reason why it should be understood as a 'pragmatic' discipline.

  6. The flotation of Roşia Poieni copper ore in column machine, with non-polar oils addition

    Directory of Open Access Journals (Sweden)

    Ciocani V.

    2005-11-01

    Full Text Available The most important natural resource of copper in Romania is the ore deposit of Roşia Poieni. At present, the utilization of Roşia Poieni poorphyry copper ore is possible by extraction in quarry of the mass ore and mineral processing into a technological flux with modest results for the value of metal recovery in concentrate 70-72 % and an average contents of 16,5 % Cu. Our researches were directed to studies regarding test and utilisation of special procedure of flotation – addition of the non-polar oil – applied to advanced grinding ore with column type machines.

  7. 46 CFR 199.100 - Manning of survival craft and supervision.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Manning of survival craft and supervision. 199.100....100 Manning of survival craft and supervision. (a) There must be a sufficient number of trained... craft and launching arrangements required for abandonment by the total number of persons on board. (c...

  8. Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: an in vitro study

    Directory of Open Access Journals (Sweden)

    V. Mitolo

    2011-09-01

    Full Text Available Obiettivo: Lo scopo di questo studio è stato valutare la produzione di TNF-α, induttore della via estrinseca del processo apoptotico, in seguito al trattamento con gli autoanticorpi anti-Ro ed anti-La isolati da pazienti con sindrome di Sjögren primaria in un modello sperimentale rappresentato dalla linea cellulare di ghiandole salivari umane, A- 253. È stata, inoltre, valutata la presenza sulla superficie di tali cellule di recettori specifici per tale induttore, TNFR1 e TNFR2. Materiali e metodi: Gli autoanticorpi anti-La ed anti-Ro sono stati purificati su una colonna cromatografia ad alta affinità. Le metodiche utilizzate per la valutazione della produzione di TNF-α e lo studio dei recettori di superficie sono state immunofluorescenza, RT-PCR e saggi immunoenzimatici. Risultati: I nostri risultati hanno dimostrato che le cellule A-253 esprimono in superficie i recettori TNFR1 e TNFR2 e che gli autoanticorpi anti-Ro e anti-La sono in grado di indurre la produzione di TNF-α nelle stesse cellule. Conclusioni: Il trattamento con gli autoanticorpi anti-Ro ed anti-La induce la produzione di TNF-α in cellule di ghiandole salivari umane e questo potrebbe spiegare la attivazione della via estrinseca della apoptosi.

  9. Synergistic Man: Outcome Model for Counselors

    Science.gov (United States)

    Rousseve, Ronald J.

    1973-01-01

    Drawing on the insights of Ruth Benedict and Abraham Maslow in their search for an ethical gauge by which to rate personal-social health, this article proposes synergistic man'' as the desired outcome model for counselors. (Author)

  10. 46 CFR 109.323 - Manning of survival craft and supervision.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Manning of survival craft and supervision. 109.323... DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and supervision. (a) There must be a sufficient number of trained persons on board the survival craft for...

  11. The Creation of Man and Woman in Early Jewish Literature

    NARCIS (Netherlands)

    Ruiten, J.T.A.G.M. van; Luttikhuizen, G P

    2000-01-01

    J.T.A.G.M. van Ruiten, “The Creation of Man and Woman in Early Jewish Literature,” in The Creation of Man and Woman: Interpretations of the Biblical Narratives in Jewish and Christian Traditions (ed. Gerard P. Luttikhuizen; Themes in Biblical Narrative 3; Leiden, Boston, and Köln: Brill, 2000),

  12. Proposed man-rem reference values of occupational exposure

    International Nuclear Information System (INIS)

    Lombard, J.

    1988-04-01

    This report presents a proposal of referent collective dose (man-rem) values for occupational exposure related to operation of French pressurized water reactors. These values, permitting adequate choice of protection both at design and operation level, are dependent on the level of annual individual doses. The man-rem value, originating from annual individual doses less than 0.5 rem are estimated to 1 kf. The proposed value is 20 kf for annual individual exposures between 0.5 and 3 rem, and 90 kf for annual individual exposures between 3 and 5 rem. (author) [fr

  13. Radiocaesium transfer to man from moose and roe deer in Sweden

    International Nuclear Information System (INIS)

    Johanson, Karl J.; Bergstroem, R.

    1994-01-01

    Studies of radiocaesium in the forest ecosystems in Sweden resulted in aggregated transfer factors quantified for the transfer of 137 Cs from soil to moose and roe deer. These aggregated transfer factors were 0.02 m 2 kg -1 for moose and 0.05 m 2 kg -1 for roe deer. There seems to be no decrease in the 137 Cs activity concentrations in moose harvested in our research area and therefore we suggest the use of the physical half-life of 137 Cs (30 years) as the effective ecological half-life. The time-integrated transfer of 137 Cs from the Chernobyl fall-out to man by moose in Sweden was calculated and found to be 115 GBq, corresponding to 1500 man Sv for moose. The time-integrated transfer by roe deer to man was estimated to be between 25-48 GBq, corresponding to 327-620 man Sv for roe deer. The annual transfer of 137 Cs to man by moose has varied between 2.0-2.7 GBq, corresponding to 27-34 man Sv. Depending on the group studied, the mean annual transfer of 137 Cs can be calculated to be from about 250 to 43'000 Bq. For example, the mean annual transfer of 137 Cs by moose to hunters and their families in Gaevle commune, the most affected commune in Sweden, was estimated to be about 26'000 Bq, corresponding to 0.34 mSv

  14. A new tool for man/machine integration

    International Nuclear Information System (INIS)

    Sommer, W.C.

    1981-01-01

    A popular term within the nuclear power industry today, as a result of TMI, is man/machine interface. It has been determined that greater acknowledgement of this interface is necessary within the industry to integrate the design and operational aspects of a system. What is required is an operational tool that can be used early in the engineering stages of a project and passed on later in time to those who will be responsible to operate that particular system. This paper discusses one such fundamental operations tool that is applied to a process system, its display devices, and its operator actions in a methodical fashion to integrate the machine for man's understanding and proper use. This new tool, referred to as an Operational Schematic, is shown and described. Briefly, it unites, in one location, the important operational display devices with the system process devices. A man can now see the beginning and end of each information and control loop to better understand its function within the system. A method is presented whereby in designing for operability, the schematic is utilized in three phases. The method results in two basic documents, one describes ''what'' is to be operated and the other ''how'' it is to be operated. This integration concept has now considered the hardware spectrum from sensor-to-display and operated the display (on paper) to confirm its operability. Now that the design aspects are complete, the later-in-time operational aspects need to be addressed for the man using the process system. Training personnel in operating and testing the process system is as important as the original design. To accomplish these activities, documents are prepared to instruct personnel how to operate (and test) the system under a variety of circumstances

  15. The PH-D proposal - A manned mission to PHOBOS and Deimos

    Science.gov (United States)

    Singer, S. F.

    The rationale for a manned mission to the satellites of Mars is discussed. The view has been expressed that NASA must define a major program to follow the Shuttle and to utilize it. However, such a program could not be initiated and proceed without public support, and to obtain this support, public interest would have to be excited. It is shown that, of a number of possible targets for manned exploration in the solar system, Mars appears to be the only possible candidate. Attention is given to a comparison of three Mars missions, a Mars 1984 mission, a manned landing on Mars surface, a manned landing on Phobos and Deimos (Ph-D project), putting men in Mars orbit, the capabilities of the Ph-D mission, a description of the spacecraft, a Ph-D project operations plan, and aspects of timing, technology, and costs.

  16. Health, Sanitary and Economic Evaluation of Home-like Systems of Water Treatment (Reverse Osmosis, RO in Qom City

    Directory of Open Access Journals (Sweden)

    Mohammadreza Jafaripour

    2011-07-01

    Full Text Available Reverse Osmosis (RO is one of the most useful techniques to improve the elimination of organic and mineral Substances from ground and surface water after primary purification processes such as coagulation, sedimentation and filtration.This System provides the required water quality characteristics to somehow.  However, in selection RO systems civil management decision and general public opinion along with cost and health impact must be considered. This study was done in 2010. Statistical methods have used to gather data about of families who used RO In their private homes and mode of eliminate of the wastewater generated by this process. The results indicated that in the normal operational conditions such as pressure 6- 10 kg / cm2 the, optimum recovery % 30 and flow rate 1lit/min , and water temperature 4- 38C°, an Amount of 14191200 kwh of power energy have been consumed to produce 157680 m3 / year treated water required for 36000 families. This has also generated 367920 m3 / year of wastewater being disposed without any management and environmental considerations. Apart from that more than 198000 of filters have been ejected to the environment. Also regarding health aspects, reducing the hardness and fluoride levels in treated water could be undesirable. It could be concluded that increasing the number of local water distribution points and speeding up the water supplying project from Dez river toQom can decrease the investment on RO system.

  17. Abstraction of man-made shapes

    KAUST Repository

    Mehra, Ravish; Zhou, Qingnan; Long, Jeremy; Sheffer, Alla; Gooch, Amy Ashurst; Mitra, Niloy J.

    2009-01-01

    Man-made objects are ubiquitous in the real world and in virtual environments. While such objects can be very detailed, capturing every small feature, they are often identified and characterized by a small set of defining curves. Compact, abstracted shape descriptions based on such curves are often visually more appealing than the original models, which can appear to be visually cluttered. We introduce a novel algorithm for abstracting three-dimensional geometric models using characteristic curves or contours as building blocks for the abstraction. Our method robustly handles models with poor connectivity, including the extreme cases of polygon soups, common in models of man-made objects taken from online repositories. In our algorithm, we use a two-step procedure that first approximates the input model using a manifold, closed envelope surface and then extracts from it a hierarchical abstraction curve network along with suitable normal information. The constructed curve networks form a compact, yet powerful, representation for the input shapes, retaining their key shape characteristics while discarding minor details and irregularities. © 2009 ACM.

  18. [The man on the portrait].

    Science.gov (United States)

    Bergstrand, A

    1996-01-01

    Marie Curie was awarded the Nobel Prize in chemistry 1911. During the preceding year a rumour had circulated in Stockholm that she had had an affaire with one of her assistants. She received a letter, in which she was told that there had been strong opposition to her election not on scientific but moral grounds, and that she should not go to Stockholm, because nobody could forsee what reactions her appearance at the prize ceremony could evoke. Emil Kleen, a man of violent temper and radical opinions, reacted strongly to these rumours. He wrote a paper, with a violent attack on Gustaf Retzius, previous professor of Histology at Karolinska Institutet. Rightly or wrongly he suspected him to be the author of the infamous letter. Retzius is described as a dilletant in scientific matters, as a "sexual hyena" and a garroulus old man. This portrait of Retzius is of course most unfair, but the portrait of Emil Kleen by the famous swedish artist Bruno Liljefors is a masterpiece and one of the most valuable of the Swedish Medical Association.

  19. Natural and man-made terrestrial electromagnetic noise: an outlook

    Directory of Open Access Journals (Sweden)

    A. Meloni

    2007-06-01

    Full Text Available The terrestrial environment is continuously exposed to electromagnetic radiations which set up a «background» electromagnetic noise. Within the Non Ionizing Radiation band (NIR, i.e. for frequencies lower than 300 GHz, this background can have a natural or an artificial origin. Natural origins of electromagnetic radiations are generally atmospheric or cosmic while artificial origins are technological applications, power transmission, communications, etc. This paper briefly describes the natural and man-made electromagnetic noise in the NIR band. Natural noise comes from a large variety of sources involving different physical phenomena and covering a wide range of frequencies and showing various propagation characteristics with an extremely broad range of power levels. Due to technological growth man-made electromagnetic noise is nowadays superimposed on natural noise almost everywhere on Earth. In the last decades man-made noise has increased dramatically over and above the natural noise in residential and business areas. This increase has led some scientists to consider possible negative effects of electromagnetic waves on human life and living systems in general. Accurate measurements of natural and man-made electromagnetic noise are necessary to understand the relative power levels in the different bands and their influence on life.

  20. A review of warship man-machine-environment system engineering

    Directory of Open Access Journals (Sweden)

    ZHANG Yumei

    2017-03-01

    Full Text Available Warship Man-Machine-Environment System Engineering (MMESE is an integral part of the overall design, and its design principles were proposed according to safety, efficiency, comfort and pleasure. The typical characteristics of MMESE are summarized. The operating environment is extremely terrible on long voyages. High level collaboration is required due to the complex task system and large manpower demand. Owing to the dense computer interface information, the mental cognitive burden on the crew is heavy. The MMESE technology system is divided into four parts:man-machine coordinated, man-environment coordinated, the evaluation of man-machine-environment characteristics and the ergonomic simulation. Based on the MMESE development venation in this paper, the overseas and domestic research statuses are expounded. Interactive optimization can be realized according to the following aspects:researching the basic human characteristics of the crew, applying this to the warship's overall design, and formulating relevant ergonomic standards and norms. Next, Human System Integration (HSI professional engineering was introduced comprehensively into the marines in order to achieve an optimal system. On this basis, we completed the future development trend analysis. All these studies and results have some reference meaning for guiding the integrated optimization of warships as a whole, downsizing the manpower and improving efficiency.

  1. Man, Satan, and God of Mawlana (Rumi and Milton

    Directory of Open Access Journals (Sweden)

    Leila Mir Mojarabian

    2013-09-01

    Full Text Available This research is a critical analysis on the place of human and his integration with religious issues, and the subject of disobedience and rebellion. In addition, topics such as reward, punishment, redemption and salvation of mankind in two great works of literature of the world, Masnavi by Mawlana and Paradise Lost by Milton have been comparatively discussed.     Rumi's poetry and thought has been accepted by commons and special people in Iran and the world. Rumi is one of the few supreme poets in Persian language and the world. Generally, Milton has Known as the greatest English poet after Shakespeare, and his Paradise Lost as the greatest English fiction poem. This work is a the well-known epics of human-divine composed in live new languages, and comparing these two works even in one field of speech, indeed is the comparison of two thoughts, two nations, and two ancient cultures.     The author attempts to examine the similarities and contrasts of the two poems of these two great poets on the subjects of human, God, and Satan and the world, to achieve the analytical and critical comparison of them in this context. In this paper the author tries to base the Paradise Lost of Milton and compare it with the ideas of Mawlana common to imagine man's first story and his disobedience, religious approaches, and finally the end presumed for mankind.     In these two poems, contrast between "God" and "man" is derived from the fundamental relationship between "God" and "man". Milton while calls God, our Heavenly Father and refer to his role of creativity, entitles him as the dominant power, All mighty, the victorious winner, Glorious and Holy ruler, powerful king, and in one word, omnipotent. The Creator that all creatures are worshiping him, the omnipotent could be seen his capability remarks in everywhere, the unique structure of the universe beautiful is his own and the glorious ruler, sitting over the skies, sometimes invisible and sometimes

  2. Man, Satan, and God of Mawlana (Rumi and Milton

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Nasre Esfahani

    2013-08-01

    Full Text Available This research is a critical analysis on the place of human and his integration with religious issues, and the subject of disobedience and rebellion. In addition, topics such as reward, punishment, redemption and salvation of mankind in two great works of literature of the world, Masnavi by Mawlana and Paradise Lost by Milton have been comparatively discussed.     Rumi's poetry and thought has been accepted by commons and special people in Iran and the world. Rumi is one of the few supreme poets in Persian language and the world. Generally, Milton has Known as the greatest English poet after Shakespeare, and his Paradise Lost as the greatest English fiction poem. This work is a the well-known epics of human-divine composed in live new languages, and comparing these two works even in one field of speech, indeed is the comparison of two thoughts, two nations, and two ancient cultures.     The author attempts to examine the similarities and contrasts of the two poems of these two great poets on the subjects of human, God, and Satan and the world, to achieve the analytical and critical comparison of them in this context. In this paper the author tries to base the Paradise Lost of Milton and compare it with the ideas of Mawlana common to imagine man's first story and his disobedience, religious approaches, and finally the end presumed for mankind.     In these two poems, contrast between "God" and "man" is derived from the fundamental relationship between "God" and "man". Milton while calls God, our Heavenly Father and refer to his role of creativity, entitles him as the dominant power, All mighty, the victorious winner, Glorious and Holy ruler, powerful king, and in one word, omnipotent. The Creator that all creatures are worshiping him, the omnipotent could be seen his capability remarks in everywhere, the unique structure of the universe beautiful is his own and the glorious ruler, sitting over the skies, sometimes invisible and sometimes

  3. Constructing EuroMan

    DEFF Research Database (Denmark)

    Sandberg, Marie; Andersen, Dorte

    2008-01-01

    the regional periphery in dynamic state-centred economies. In the course of the 1980s, however, interest has shifted towards regions as motors of growth, thereby making the region an actor in its own right rather than a passive receiver of subsidies. The shift in focus can be regarded a result of so...... and approaches. Eurman is possessing the ability and will to pursue rational-strategic goals and he appears in the form of an economic agent as well as a participant in political processes. Regionalisation, identity-formation and the key characteristics of EuroMan unite in EU regional policies and New...

  4. Battre sa (super) coulpe : Spider-Man (1962)

    OpenAIRE

    Tomasovic, Dick

    2016-01-01

    L’édification est l'une des grandes fonctions traditionnelles de la littérature de jeunesse. Spider-Man, héros populaire s'il en est, s'est révélé bien sûr l'ambassadeur de nombreuses valeurs sociétales américaines (le do it yourself, l'esprit d'entreprise et d'indépendance, la tolérance, la fidélité , la célébration du système éducationnel, la transmission et la solidarité intergénérationnelle, le sens des responsabilités, évidemment, etc.). Spider-Man se bat moins qu'il ne se débat. Il est ...

  5. Transient behaviour and coupling aspects of a hybrid MSF-RO nuclear desalination plant

    International Nuclear Information System (INIS)

    Tewari, P.K.; Misra, B.M.

    1998-01-01

    BARC is setting up a 6300 M 3 /day (1.4 MGD) hybrid MSF-RO nuclear desalination plant for sea water desalination at Madras Atomic Power Station (MAPS) coupled to a 170 MWe Pressurised Heavy Water Reactor (PHWR). The transient behaviour and coupling aspects of this dual purpose plant has been discussed. A hybrid desalination plant appears to offer high availability factor. (author)

  6. Man and His Environment: To Perceive and to React: Language Arts. 5111.13.

    Science.gov (United States)

    Bermudez, Lynne L.

    A course which is an investigation and appraisal of prose, poetry, fine arts, and music which reflects the environment's effect on man or man's effect on his environment is presented. Performance objectives include the following: (1) Students will formulate a definition of what constitutes man's environment; (2) Students will examine the reactions…

  7. A report on reference Japanese man

    International Nuclear Information System (INIS)

    1979-01-01

    In connection with the reference Japanese man for evaluation of accurate exposure doses considering the various characteristics, survey data of organs etc. weights and dimensions are given: renal glands, brains, kidneys, liver, lungs, womb, thyroid glands, gallbladder, stomach. (Mori, K.)

  8. Trust between man and machine in a teleoperation system

    International Nuclear Information System (INIS)

    Dassonville, I.; Jolly, D.; Desodt, A.M.

    1996-01-01

    The work we present deals with the trust of man in a teleoperation system. Trust is important because it is linked to stress which modifies human reliability. We are trying to quantify trust. In this paper, we'll present the theory of trust in relationships, and its extension for a man-machine system. Then, we explain the links between trust and human reliability. Then, we introduce our experimental process and the first results concerning selfconfidence

  9. The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

    KAUST Repository

    Salinas-Rodriguez, Sergio G.; Amy, Gary L.; Schippers, Jan C.; Kennedy, Maria D.

    2015-01-01

    that remain on the surface of membrane) were measured in a full-scale plant ranging between 0.2 and 0.5. The concept of “safe MFI” is presented as a guideline for assessing pre-treatment for RO systems.

  10. Changes of seizure susceptibility during benzodiazepine withdrawal in immature rats: comparison of clonazepam and partial benzodiazepine agonist Ro 19-8022

    Czech Academy of Sciences Publication Activity Database

    Kubová, Hana

    2006-01-01

    Roč. 47, č. S4 (2006), s. 221-221 ISSN 0013-9580. [Annual Meeting of the American Epilepsy Society and Canadian League against Epilepsy. 01.12.2006-05.12.2006, San Diego, CA] R&D Projects: GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : PTZ-induced seizures * clonazepam * agonist Ro 19-8022 Subject RIV: ED - Physiology

  11. Bioethics against disappearance of a man a prism of general and criminal-law theory

    Directory of Open Access Journals (Sweden)

    Trajković Marko

    2015-01-01

    Full Text Available Bioethics, as a meeting point, engrossed with its fight against the disappearance of the man, both general and criminal-law theory. Actually, its 'care' for the man is an issue that comes before general and criminal-law theory. While the forms of disappearance of the man are very diverse and very often so refined that they cannon sometimes be recognized, the fight against the disappearance of the man must be open, clear and uncompromising. What is the role of law in this fight? The role imposed itself. Even if the law did not want to take part in the fight, it found itself in the middle of the battlefield because human life is protected from beginning to the end by legal norms that should emerge from the best writings of general and criminal-law theory. However, self-sufficiency of law and mere legal positivism are a true obstacle in this battle. This pressure and the lack of questionings are the first step on the road to disappearance of the man, because a man that asks questions is the man that exists. He and his boldness are a barrier to voluntarism. The lack of boldness of the man opens the gates to his disappearance. This boldness has not been taken away from him in the field of bioethics, which is neither secular nor religious, but rather unique as the man is unique.

  12. Timing Analysis of SSL/TLS Man in the Middle Attacks

    OpenAIRE

    Benton, Kevin; Bross, Ty

    2013-01-01

    Man in the middle attacks are a significant threat to modern e-commerce and online communications, even when such transactions are protected by TLS. We intend to show that it is possible to detect man-in-the-middle attacks on SSL and TLS by detecting timing differences between a standard SSL session and an attack we created.

  13. Yaacov Ro´i, Boris Morozov, eds, The Soviet Union and the June 1967 Six Day War

    OpenAIRE

    Rey, Marie-Pierre

    2009-01-01

    L’ouvrage coordonné par Yaacov Ro´i et Boris Morozov réunit neuf contributions qui, émanant de chercheurs américains, russes et israéliens et toutes fondées sur des archives depuis peu accessibles, éclaire de manière nouvelle et convaincante la question de l’engagement et du rôle de l’Union soviétique durant la guerre des Six Jours. Cinq articles présentés dans le volume traitent directement de l’attitude soviétique à l’heure du conflit. Le premier, rédigé par Yaacov Ro´i, traite de l’engagem...

  14. The institutionalization of Jesus' charismatic authority: "Son of Man" as case study1

    Directory of Open Access Journals (Sweden)

    Yolanda Dreyer

    2000-12-01

    Full Text Available This article argues that Jesus used the expression "son of man" not in a titular way, but genetically, meaning "humankind". This use of "son of man" developed into a titular usage in which Jesus is identified with "Son of Man". The study shows that Jesus' use of the expression "son of man" should be understood in the context of the "little tradition" which was reinterpreted in terms of the "great tradition" in a titular way. It is argued that this transition from "litle tradition" to "great tradition"can be seen as "false attribution". After Jesus' death when his followers reorganized themselves into a cultic community, they gave Jesus the position "founder of the cult". They did this by making use of honorary titles. The use of the title "Son of Man" for Jesus is interpreted in terms of the social theory of the institutionalization of charismatic authority. The focus is on the title "Son of Man" as it appears in legal sayings or church rules, wisdom sayings and prophetic and apocalyptic sayings.

  15. Man-Made Object Extraction from Remote Sensing Imagery by Graph-Based Manifold Ranking

    Science.gov (United States)

    He, Y.; Wang, X.; Hu, X. Y.; Liu, S. H.

    2018-04-01

    The automatic extraction of man-made objects from remote sensing imagery is useful in many applications. This paper proposes an algorithm for extracting man-made objects automatically by integrating a graph model with the manifold ranking algorithm. Initially, we estimate a priori value of the man-made objects with the use of symmetric and contrast features. The graph model is established to represent the spatial relationships among pre-segmented superpixels, which are used as the graph nodes. Multiple characteristics, namely colour, texture and main direction, are used to compute the weights of the adjacent nodes. Manifold ranking effectively explores the relationships among all the nodes in the feature space as well as initial query assignment; thus, it is applied to generate a ranking map, which indicates the scores of the man-made objects. The man-made objects are then segmented on the basis of the ranking map. Two typical segmentation algorithms are compared with the proposed algorithm. Experimental results show that the proposed algorithm can extract man-made objects with high recognition rate and low omission rate.

  16. S.I. 1987 No.688, The Nuclear Installations (Isle of Man) (Variation) Order 1987

    International Nuclear Information System (INIS)

    1987-01-01

    This Order, which amends the Nuclear Installations (Isle of Man) Order 1977, came into force on 7 May 1987. The Nuclear Installations (Isle of Man) Order 1977 extends certain provisions of the Nuclear Installations Act 1965 as appropriate, to the Isle of Man. This Order extends amendments made to that Act by the Energy Act 1983 and the Congenital Disabilities (Civil Liability) Act 1976, as appropriate, to the Isle of Man. (NEA) [fr

  17. State of the art of the production and utilization of biogas using the NawaRo plant; Stand der Technik bei der Erzeugung und Nutzung von Biogas unter Einsatz von NawaRo-Anlagen

    Energy Technology Data Exchange (ETDEWEB)

    Weiland, P.; Rieger, C.; Schroeder, J. [Bundesforschungsanstalt fuer Landwirtschaft (FAL), Braunschweig (Germany); Kissel, R.; Bachmaier, H. [LfL, Freising (Germany); Plogsties, V. [ATB, Potsdam (Germany); Vogtherr, J. [Hohenheim Univ., Stuttgart (Germany)

    2007-07-01

    With amending the Renewable Energy Law (EEG) in August 2004 the fundamentals for the utilization of renewable raw materials in biological gas facilities were created. Since that time the number of installed plants processing energy plants grew very fast, although at the time of amending only few experiences with NawaRo plants were present. Therefore, in order to attain secured informations about the current state of the art in the production and utilization of fermentation gas to, in the context of a country wide measuring program, NawaRo plants are examined and evaluated according to technical and economic criteria. The results determined so far show that due to the intensified employment by energy plants completely new dosing systems and agitating systems are applied, and also pure fermentation techniques for solids increasingly are used for the mono fermentation of renewable raw materials. Although the common generation of current and heat in cogeneration plants dominate, new use routes like the feed of bio methane in the natural gas grid as well as the utilization of the gas as fuel gain in importance.

  18. ÜRO rahuvalvajatel lasub taas laste ahistamise süüdistus / Oliver Tiks, Hendrik Vosman

    Index Scriptorium Estoniae

    Tiks, Oliver

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 28. mai 2008, lk. 5. Briti heategevusorganisatsiooni Save the Children raport avalikustas, et maailma kriisipiirkondades on lapsed sattunud neid turvama saadetud ÜRO rahuvalvajate ja abitöötajate seksuaalse kuritarvitamise ohvriks. Lisa: Seksiskandaalid

  19. Differential effect of detergents on [3H]Ro 5-4864 and [3H]PK 11195 binding to peripheral-type benzodiazepine-binding sites

    International Nuclear Information System (INIS)

    Awad, M.; Gavish, M.

    1988-01-01

    The present study demonstrates a differential effect of various detergent treatments on [ 3 H]Ro 5-4864 and [ 3 H]PK 11195 binding to peripheral benzodiazepine binding sites (PBS). Triton X-100 caused a decrease of about 70% in [ 3 H]Ro 5-4864 binding to membranes from various peripheral tissues of rat, but had only a negligible effect on [ 3 H]PK 11195 binding. A similar effect of Triton X-100 was observed on guinea pig and rabbit kidney membranes. The decrease in [ 3 H]Ro 5-4864 binding after treatment with Triton X-100 was apparently due to a decrease in the density of PBS, since the affinity remained unaltered. The detergents 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate (CHAPS), Tween 20, deoxycholic acid, or digitonin (0.0125%) caused only a minor change in [ 3 H]Ro 5-4864 and [ 3 H]PK 11195 binding to rat kidney membranes; but when concentrations were substantially increased (0.1%), all detergents caused a decrease of at least 50% in [ 3 H]Ro 5-4864 binding, while [ 3 H]PK 11195 binding to rat kidney membranes remained unaffected by the first three detergents, with only a minor decrease (15%) after treatment with digitonin

  20. The End of Man

    OpenAIRE

    Martinon, Jean-Paul

    2013-01-01

    Masculinity? This book attempts to answer this one-word question by revisiting key philosophical concepts in the construction of masculinity, not in order to re-write or debunk them again, but in order to provide a radically new departure to what masculinity means today. This new departure focuses on an understanding of sexuality and gender that is neither structured in oppositional terms (masculine-feminine, male-female, man-woman) nor in performative terms (for which the opposition remains ...

  1. Man Is a Paradox

    Institute of Scientific and Technical Information of China (English)

    王茂娟

    2009-01-01

    In the poem "Always", the author Pablo Neruda employs the first person narration to incisively reveal the paradoxical traits in human nature by exploring man in relation to love. "I" play a role shifting from a calm narrator to a furious one, and the last recovering to a mild one, which offers a multiple visual angle to observe humanity. In sum, by means of continuous changes of my inner feelings in the poem, Pablo Neruda reveals the paradoxical humanity .

  2. Man-caused seismicity of Kuzbass

    Science.gov (United States)

    Emanov, Alexandr; Emanov, Alexey; Leskova, Ekaterina; Fateyev, Alexandr

    2010-05-01

    A natural seismicity of Kuznetsk Basin is confined in the main to mountain frame of Kuznetsk hollow. In this paper materials of experimental work with local station networks within sediment basin are presented. Two types of seismicity display within Kuznetsk hollow have been understood: first, man-caused seismic processes, confined to mine working and concentrated on depths up to one and a half of km; secondly, seismic activations on depths of 2-56 km, not coordinated in plan with coal mines. Every of studied seismic activations consists of large quantity of earthquakes of small powers (Ms=1-3). From one to first tens of earthquakes were recorded in a day. The earthquakes near mine working shift in space along with mine working, and seismic process become stronger at the instant a coal-plough machine is operated, and slacken at the instant the preventive works are executed. The seismic processes near three lavas in Kuznetsk Basin have been studied in detail. Uplift is the most typical focal mechanism. Activated zone near mine working reach in diameter 1-1,5 km. Seismic activations not linked with mine working testify that the subsoil of Kuznetsk hollow remain in stress state in whole. The most probable causes of man-caused action on hollow are processes, coupled with change of physical state of rocks at loss of methane from large volume or change by mine working of rock watering in large volume. In this case condensed rocks, lost gas and water, can press out upwards, realizing the reverse fault mechanism of earthquakes. A combination of stress state of hollow with man-caused action at deep mining may account for incipient activations in Kuznetsk Basin. Today earthquakes happen mainly under mine workings, though damages of workings themselves do not happen, but intensive shaking on surface calls for intent study of so dangerous phenomena. In 2009 replicates of the experiment on research of seismic activations in area of before investigated lavas have been conducted

  3. Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration.

    Science.gov (United States)

    Zheng, Peihe; Chen, Yinbin; Fu, Yangyang; Wang, Hecheng; Wang, Jia; Zheng, Siwen; Xiao, Shengyuan; Wang, Yingping

    2017-11-01

    After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg 1 , protopanaxadiol-type saponin Rb 1 , and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg 1 , Rb 1 , and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration-time curve from zero to infinity (AUC 0-∞ ) of ginsenoside Rg 1 was reduced by 70%, that of ginsenoside Rb 1 was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC 0-∞ of ginsenosides Rg 1 and Rb 1 showed significant differences between different treatments, but the AUC 0-∞ of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg 1 , Rb 1 , and B-complex vitamins.

  4. The Somerton man : an unsolved history

    Directory of Open Access Journals (Sweden)

    Balint, Ruth

    2010-01-01

    Full Text Available The case of the unknown man who died mysteriously at Somerton Beach in South Australia in 1948 remains an open police investigation, although the trail today has grown fairly cold. Revisiting the case, and the responses the mystery of his person have elicited, enables a special historical insight into Australia’s postwar society, and the ways in which the past is continually reshaped by the subjectivities of the present. Further, an unsolved case such as this provides for a unique kind of historical project. The limitations of a history without a coherent centre are myriad, yet so are the possibilities. In this article, I explore the possibilities of an ‘unsolved history’, a history of dead ends, and argue that it is the very unknowable-ness of the Somerton Man that allows for a perception of history as multi-dimensional and complex.

  5. The Somerton Man: An Unsolved History

    Directory of Open Access Journals (Sweden)

    Ruth Balint

    2010-09-01

    Full Text Available The case of the unknown man who died mysteriously at Somerton Beach in South Australia in 1948 remains an open police investigation, although the trail today has grown fairly cold. Revisiting the case, and the responses the mystery of his person have elicited, enables a special historical insight into Australia’s postwar society, and the ways in which the past is continually reshaped by the subjectivities of the present. Further, an unsolved case such as this provides for a unique kind of historical project. The limitations of a history without a coherent centre are myriad, yet so are the possibilities.  In this article, I explore the possibilities of an ‘unsolved history’, a history of dead ends, and argue that it is the very unknowable-ness of the Somerton Man that allows for a perception of history as multi-dimensional and complex.

  6. The strangest man. The hidden life of Paul Dirac

    International Nuclear Information System (INIS)

    Farmelo, Graham

    2016-01-01

    The Strangest Man is the Costa Biography Award-winning account of Paul Dirac, the famous physicist sometimes called the British Einstein. He was one of the leading pioneers of the greatest revolution in twentieth-century science: quantum mechanics. The youngest theoretician ever to win the Nobel Prize for Physics, he was also pathologically reticent, strangely literal-minded and legendarily unable to communicate or empathize. Through his greatest period of productivity, his postcards home contained only remarks about the weather. Based on a previously undiscovered archive of family papers, Graham Farmelo celebrates Dirac's massive scientific achievement while drawing a compassionate portrait of his life and work. Farmelo shows a man who, while hopelessly socially inept, could manage to love and sustain close friendship. The Strangest Man is an extraordinary and moving human story, as well as a study of one of the most exciting times in scientific history.

  7. Mechanical Properties of Man-Made Mineral glass fibres

    DEFF Research Database (Denmark)

    Lund, Majbritt Deichgræber; Yue, Yuanzheng

    of man made mineral wool fibres, and an improvement of the mechanical performances of man made mineral wool fibres are an evitable task for us. To do so, it is important to look into the fracture behaviour and its connection to the mechanical strength. In order to improve the understanding...... of the information gained from the mechanical tests, fracture characteristics of individual glass fibres are imaged by scanning electron microscopy. The fracture surfaces showed to fall in three groups; 1) surfaces including fracture mirror, mist and hackle, 2) bend fracture surfaces and 3) surfaces including pores...

  8. Fragmented one dimensional man / El hombre unidimensional fragmentado

    Directory of Open Access Journals (Sweden)

    Juan Antonio Rodríguez del Pino

    2013-10-01

    Full Text Available Paraphrase the title of the famous essay by Herbert Marcuse, since the image has traditionally been generated of man, masculinity, has been one-dimensional. I mean, the man was characterized by traits and behaviors established and entrenched since ancient time, considering all other distinguishing signs as mere deviations from the normative improper. But observe that this undeniable reality, as analyzed various researchers through what has come to be called Men's studies, has proven to be a fallacy difficult to maintain throughout history and today turns into fallacious and ineffective against changes in our current existing corporate models.

  9. Inter-Faith Reading of Perfect Man With Mystical Approach

    Directory of Open Access Journals (Sweden)

    Fatemeh Musavi

    2010-12-01

    Full Text Available The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  10. Inter-Faith Reading of Perfect Man With Mystical Approach

    Directory of Open Access Journals (Sweden)

    Mohammadkazem Shaker

    2011-01-01

    Full Text Available   The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  11. Inter-Faith Reading of Perfect Man With Mystical Approach

    Directory of Open Access Journals (Sweden)

    Shaker, M.K

    2011-01-01

    Full Text Available The expression Insan –e kamil (perfect man is often said to have first been used by Muhyiddin ibn 'Arabi (1165 -1240AD, though the concept of the term is much older. In his theosophical teaching, the doctrine of insan e- kamil, is held a prominent place. After him two other great Sufis, Aziz Nasafi (1300AD and 'Abd al- karim ibn Ibrahim al- Jili (1366 – 1424 AD, each wrote a work on this very issue. These works are regarded as explanations of Ibn Arabi’s teachings on human perfection. In Islamic mysticism, Perfect man is the one who within their soul possesses all God's names and attributes. Thus the perfect man’s existence, reality and inner might become a clear mirror and a complete reflection of the Perfection, Beauty and Glory of the Essence of the One, so that he becomes Godlike. However, the idea of human perfectibility going back to other religions and human schools even before Islam. In Abrahimic religions there are some joint teachings that could be considered as main statements for the doctrine of Perfect Man In Jewish scriptures the notion of human creation in God's image suggests that the human being is able to be God's like and the perfection is available to him. However, Jews do not believe a perfect man. They hold that even Moses is not a perfect man. In Christianity, Although Jesus encourages his followers to be perfect like their heavenly fathers, the doctrine of original sin to be considered as an obstacle for human perfectibility.This essay examines some significant element in human perfectibility from the view points of some scholars of Judaism, Christianity and Islam and presents some similarities and differences of their view points.

  12. Biodegradation of Azo Dye RO16 in Different Reactors by Immobilized Irpex lacteus

    Czech Academy of Sciences Publication Activity Database

    Tavčar, M.; Svobodová, Kateřina; Kuplenk, J.; Novotný, Čeněk; Pavko, A.

    2006-01-01

    Roč. 53, - (2006), s. 338-343 ISSN 1318-0207 R&D Projects: GA MŠk(CZ) 1P05ME828; GA AV ČR(CZ) IAA6020411; GA ČR(CZ) GP526/06/P102 Institutional research plan: CEZ:AV0Z50200510 Keywords : irpex lacteus * dye decolorization * trickle bed reactor Subject RIV: EE - Microbiology, Virology Impact factor: 0.703, year: 2006

  13. Stavovi medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene novorođenčadi

    OpenAIRE

    Bilić, Iva; Prpić, Igor; Radić, Jelena; Vukelić, Petar; Petrović, Ana; Juretić, Emilija; Furlan, Ivanka

    2008-01-01

    CILJ: Cilj istraživanja bilo je ispitati stavove medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene djece. METODE: Pisanom anketom ispitivana je dob, roditeljstvo, radno iskustvo i mjesto rada te stavovi medicinskih sestara iz Hrvatske o primarnom oživljavanju prijevremeno rođene djece. Anketirano je 174 medicinskih sestara; 49 zaposlenih u rađaonici ili na mjestima rada sa trudnicama (Rađ/Tr), 79 u pedijatrijskim/ neonatološkim jedinicama intenzivnog liječenja (...

  14. The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites

    DEFF Research Database (Denmark)

    Jakobsen, P H; Staalsø, T; Bendtzen, K

    1995-01-01

    The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked...... to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity....

  15. State absolutism and the future of man: A historico-existential ...

    African Journals Online (AJOL)

    The wellbeing of man has been the rationale behind the original call for the erection of a state structure. Therefore, it calls to reason that any state whose existence hampers the well-being of man is but a sham, irrespective of the motive of the contractors. The quest and zest of the Anglo-Saxon contractarians for a state was ...

  16. Dvě výročí Ronalda Richtra – rodáka ze Sokolova

    Czech Academy of Sciences Publication Activity Database

    Řípa, Milan

    2011-01-01

    Roč. 59, č. 23 (2011), s. 28-28 ISSN 0040-1064 Institutional research plan: CEZ:AV0Z20430508 Keywords : fusion * Huemul Project * Juan Peron * Matterhorn * Dmitrij Sacharov * Jevgenij Tamm * Lyman Spitzer * Ronald Richter Subject RIV: BL - Plasma and Gas Discharge Physics

  17. Ecology and man's environment

    Energy Technology Data Exchange (ETDEWEB)

    Al-Naqeeb, R

    1975-01-01

    A new and exciting discipline of human ecology is in the making. It has not, perhaps fortunately, found its bearings yet and remains to date overly dependent upon the limitations of sociology, biology, engineering and the sciences for its general theory, approaches, and philosophy. A new discipline with a world view and focussed on the human being and his habitat will hopefully emerge from a rich dialectic among scientists, humanists and policy makers educated and experienced in a variety of fields and committed to man's welfare. This new discipline and its practitioner must always be open to the revelations their knowledge will bring to man through the environmental processes. The implications of public policy, science and technology of industrial and post-industrial nations are all in need of considered re-examination by us all. Since their early application in these western societies we have witnessed the general downgrading of the world's environment. An ungrading in social priorities for the development of adequate housing, jobs, medical care and education which is almost always lower in rank than they should be is needed. The role of local groups, involving a well-informed and participating citizenship, in this process of changing priorities will always remain of prime importance, but no long-range goal in a rapidly-changing landscape is possible without broad national and local planning which contains ways and means of implementation.

  18. 1958 : Manning wants markets

    International Nuclear Information System (INIS)

    Anon.

    2008-01-01

    This article described the 2 opposing views in 1958 regarding how the big Montreal refinery market should be served. While the president of Imperial Oil expressed that Montreal refineries should not be forced to use domestic feedstocks, Alberta Premier Ernest Manning urged the Borden Commission to take immediate measures to expand the market for Canadian crude oil into Montreal. Manning argued that the dependence on Venezuelan crude in the Montreal refining market would pose a danger to the stability and development of the oil industry; loss of revenue for municipal, provincial and federal governments; and, an adverse effect on Canada's trade balance with the United States. The Premier suggested that these problems could be avoided by expanding the market for Canadian crude in Ontario and Quebec, in the U.S. Midwest, and in the Pacific Northwest. In 1958, the Canadian oil industry was divided on the Montreal market issue. Other key events in 1958 were listed. Waterton was characterized as Canada's biggest gas field, with reserves of 3 trillion cubic feet. A gas discovery at Berland River was considered the largest single-well exploration find in the world, flowing 27 million cubic feet per day on 1 drillstem. Two new refineries near Vancouver and Toronto were built to raise Canadian refining capacity to 813,000 barrels per day. 1 tab., 1 fig

  19. 2-GHz band man-made noise evaluation for cryogenic receiver front-end

    Energy Technology Data Exchange (ETDEWEB)

    Narahashi, S; Satoh, K; Suzuki, Y [Research Laboratories, NTT DoCoMo, Inc., 3-5 Hikari-no-oka, Yokosuka, Kanagawa 239-8536 (Japan); Mimura, T [Intellectual Property Department, NTT DoCoMo, Inc., 2-11-1 Nagatacho, Chiyoda, Tokyo 100-6150 (Japan); Nojima, T [Graduate School of Information Science and Technology, Hokkaido University, Nishi 9, Kita 14, Kita, Sapporo 060-0808 (Japan)], E-mail: narahashi@nttdocomo.co.jp

    2008-02-01

    This paper presents measured results of man-made noise in urban and suburban areas in the 2-GHz band with amplitude probability distribution (APD) in order to evaluate the impact of man-made noise on an experimental cryogenic receiver front-end (CRFE). The CRFE comprises a high-temperature superconducting filter, cryogenically-cooled low-noise amplifier, and highly reliable cryostat that is very compact. The CRFE is anticipated to be an effective way to achieve efficient frequency utilization and to improve the sensitivity of mobile base station receivers. It is important to measure the characteristics of the man-made noise in typical cellular base station antenna environments and confirm their impact on the CRFE reception with APD because if man-made noise has a stronger effect than thermal noise, the CRFE would fail to offer any improvement in sensitivity. The measured results suggest that the contribution of man-made noise in the 2-GHz band can be ignored as far as the wideband code division multiple access (W-CDMA) system is concerned.

  20. ročí narození zakladatele brněnské balkanistiky prof. dr. Josefa Kabrdy

    Czech Academy of Sciences Publication Activity Database

    Hladký, Ladislav

    2016-01-01

    Roč. 102, č. 1 (2016), s. 159-161 ISSN 0037-6922 Institutional support: RVO:67985963 Keywords : Historian Josef Kabrda (1906–1968) * Balkan studies, history of Ottoman Empire Subject RIV: AB - History

  1. Deep-sea disposal: Protecting fish and man

    International Nuclear Information System (INIS)

    Hagen, A.

    1988-01-01

    The definition of radioactive waste unsuitable for dumping at sea is based on the protection of man. See IAEA Safety Series No. 78. The development of criteria for assessing the impact on deep sea marine organisms at the population level has been attempted in a report recently published by the IAEA. See IAEA Technical Reports Series, No. 228 (1988). The report indicates that certain radionuclides may give rise to high dose rates to marine organisms if dumping is carried out with the assumptions of instantaneous release at the sea floor and dumping over long periods of time. In the report, a hypothetical dose rate to molluscs from zinc-65, which poses no significant harm to man, has the potential for giving high doses to bottom-dwelling molluscs

  2. Automated reasoning in man-machine control systems

    International Nuclear Information System (INIS)

    Stratton, R.C.; Lusk, E.L.

    1983-01-01

    This paper describes a project being undertaken at Argonne National Laboratory to demonstrate the usefulness of automated reasoning techniques in the implementation of a man-machine control system being designed at the EBR-II nuclear power plant. It is shown how automated reasoning influences the choice of optimal roles for both man and machine in the system control process, both for normal and off-normal operation. In addition, the requirements imposed by such a system for a rigorously formal specification of operating states, subsystem states, and transition procedures have a useful impact on the analysis phase. The definitions and rules are discussed for a prototype system which is physically simple yet illustrates some of the complexities inherent in real systems

  3. Man-machine communication at Forsmark 3

    International Nuclear Information System (INIS)

    Hultquist, Goeran; Norberg, Soeren

    1984-01-01

    The design of Forsmark 3 began in 1976 and the control room layout and equipment were discussed right from the start. Susequent evolution and events in other nuclear power plants have, however, radically changed the direction of the development of the man-machine functions. (author)

  4. Man and Machines: Three Criticisms.

    Science.gov (United States)

    Schneider, Edward F.

    As machines have become a more common part of daily life through the passage of time, the idea that the line separating man and machine is slowly fading has become more popular as well. This paper examines three critics of change through their most famous works. One of the most popular views of Mary Shelley's "Frankenstein" is that it is a…

  5. 3D visualization of the internal nanostructure of polyamide thin films in RO membranes

    KAUST Repository

    Pacheco Oreamuno, Federico

    2015-11-02

    The front and back surfaces of fully aromatic polyamide thin films isolated from reverse osmosis (RO) membranes were characterized by TEM, SEM and AFM. The front surfaces were relatively rough showing polyamide protuberances of different sizes and shapes; the back surfaces were all consistently smoother with very similar granular textures formed by polyamide nodules of 20–50 nm. Occasional pore openings of approximately the same size as the nodules were observed on the back surfaces. Because traditional microscopic imaging techniques provide limited information about the internal morphology of the thin films, TEM tomography was used to create detailed 3D visualizations that allowed the examination of any section of the thin film volume. These tomograms confirmed the existence of numerous voids within the thin films and revealed structural characteristics that support the water permeance difference between brackish water (BWRO) and seawater (SWRO) RO membranes. Consistent with a higher water permeance, the thin film of the BWRO membrane ESPA3 contained relatively more voids and thinner sections of polyamide than the SWRO membrane SWC3. According to the tomograms, most voids originate near the back surface and many extend all the way to the front surface shaping the polyamide protuberances. Although it is possible for the internal voids to be connected to the outside through the pore openings on the back surface, it was verified that some of these voids comprise nanobubbles that are completely encapsulated by polyamide. TEM tomography is a powerful technique for investigating the internal nanostructure of polyamide thin films. A comprehensive knowledge of the nanostructural distribution of voids and polyamide sections within the thin film may lead to a better understanding of mass transport and rejection mechanisms in RO membranes.

  6. 3D visualization of the internal nanostructure of polyamide thin films in RO membranes

    KAUST Repository

    Pacheco Oreamuno, Federico; Sougrat, Rachid; Reinhard, Martin; Leckie, James O.; Pinnau, Ingo

    2015-01-01

    The front and back surfaces of fully aromatic polyamide thin films isolated from reverse osmosis (RO) membranes were characterized by TEM, SEM and AFM. The front surfaces were relatively rough showing polyamide protuberances of different sizes and shapes; the back surfaces were all consistently smoother with very similar granular textures formed by polyamide nodules of 20–50 nm. Occasional pore openings of approximately the same size as the nodules were observed on the back surfaces. Because traditional microscopic imaging techniques provide limited information about the internal morphology of the thin films, TEM tomography was used to create detailed 3D visualizations that allowed the examination of any section of the thin film volume. These tomograms confirmed the existence of numerous voids within the thin films and revealed structural characteristics that support the water permeance difference between brackish water (BWRO) and seawater (SWRO) RO membranes. Consistent with a higher water permeance, the thin film of the BWRO membrane ESPA3 contained relatively more voids and thinner sections of polyamide than the SWRO membrane SWC3. According to the tomograms, most voids originate near the back surface and many extend all the way to the front surface shaping the polyamide protuberances. Although it is possible for the internal voids to be connected to the outside through the pore openings on the back surface, it was verified that some of these voids comprise nanobubbles that are completely encapsulated by polyamide. TEM tomography is a powerful technique for investigating the internal nanostructure of polyamide thin films. A comprehensive knowledge of the nanostructural distribution of voids and polyamide sections within the thin film may lead to a better understanding of mass transport and rejection mechanisms in RO membranes.

  7. Influence map baserad Ms. Pac-Man och Ghost Kontroller

    OpenAIRE

    Svensson, Johan

    2012-01-01

    This thesis will cover the use oftheinfluence map technique applied to the retro game Ms. Pac-Man. A game thatis easy to learn but hard to master. The Ms. Pac-Man controller is implemented with five main parameters that alters the behaviour of the controller while the Ghost controller have three parameters. The experimental results of the controllers is explored to using the alterations of the parameters to find its peak of performance. The conclusion from using the influence map for this gam...

  8. Heidegger: Sense-Nonsense Dualism of Man in Technology Dimensions

    OpenAIRE

    Nathalia Andrea Álvarez

    2008-01-01

    This article tries to analyze the ontological-existential compromise that man acquires when using new technologies, in the light of theHeideggerian’ proposal. This compromise means, on the one hand, theresponsibility of forgetting the self in technology, which immerses man in a non-sense; and on the other, the will to open himself to the recognition of the ways in which his “being-in-the-world” manifests. To this end, the perils of technological “instrumentalization” will be presented, based ...

  9. Fresh water production from municipal waste water with RO membrane technology and its application for agriculture and industry in arid area

    International Nuclear Information System (INIS)

    Yokoyama, F

    2015-01-01

    One of the biggest problems of the 21st century is the global water shortage. Therefore it is difficult to increase the quantity of conventional water resources such as surface water and groundwater for agriculture and industry in arid area. Technical advancement in water treatment membrane technology including RO membrane has been remarkable especially in recent years. As the pore size of RO membrane is less than one nanometer, it is possible to produce the fresh water, which satisfies the drinking water quality standards, with utilizing RO membrane. In this report a new fresh water resource from municipal waste water is studied to apply to the plant factory which is the water saving type agriculture and industry in arid area

  10. Life and work of Dr. Johannes Govertus de Man (1850-1930)

    NARCIS (Netherlands)

    Karssen, G.

    2006-01-01

    This book describes the life and work of Dr. Johannes Govertus de Man (1850-1930), a remarkable Dutch invertebrate zoologist. J.G. de Man worked on the systematics of both the Crustacea, in particular on Decapoda (i.e. crabs, crayfish, lobsters and shrimps), and the microscopically Nematoda or

  11. Methods for the determination of the man-Sievert monetary value

    International Nuclear Information System (INIS)

    Lombard, J.

    1986-03-01

    To estimate the efficiency of radiological protection systems we have to compare the cost involved in putting each system into operation (cost of protection) to the collective dose that can thus be avoided. This comparison is facilitated if a man-Sievert monetary value is available. The man-Sievert value can be estimated from various detriments than can be attributed to this unitary exposure: whether there are lethal or non-lethal somatic effects, genetic effects and psycho-social effects. ICRP recommends, in its publication 37, to break down the cost of radiological detriment Y into two parts. The first part, Y1=αS, corresponds to the somatic and genetic effects; the second part, Y2=β ΣN j f(Hj), corresponds to the relevant effects of psycho-social considerations. This breakdown leads to the definition of two man-Sievert value components: α, which reflects somatic and genetic detriments; and β, which reflects the psycho-social effects. Several different methods can be used to determine α and β. Here, we will analyse the following: the a priori evaluation based on the Value of Human Life (VHL) or the costs of repair (for non-lethal effects); the a priori evaluation based on the loss of life expectancy; the evaluation based on what an individual would agree to give up to reduce the risk associated to a man Sievert-dose; the evaluation based on the expenses effectively incurred in the past to reduce the risk associated to a man-Sievert dose [fr

  12. Application of monochloramine for wastewater reuse: Effect on biostability during transport and biofouling in RO membranes

    KAUST Repository

    Siddiqui, Amber; Loubineaud, E.; Prest, E.I.E.C.; El Chakhtoura, Joline; Salles, C.; Bucs, Szilard; Trampé , J.; Van den Broek, W.B.P.; Van Agtmaal, J.M.C.; Van Loosdrecht, M.C.M.; Kruithof, J.C.; Vrouwenvelder, Johannes S.

    2018-01-01

    The rising demand for clean and safe water has increased the interest in advanced wastewater treatment and reuse. Reverse osmosis (RO) can provide reliable and high-quality water from treated wastewater. Biofouling inevitably occurs, certainly

  13. Zamyšlení nad publikací Ročenka konkurenceschopnosti České republiky 2005

    Czech Academy of Sciences Publication Activity Database

    Lízal, Lubomír

    2006-01-01

    Roč. 54, č. 4 (2006), s. 549-556 ISSN 0032-3233 Institutional research plan: CEZ:AV0Z70850503 Keywords : competitive ness * Czech Republic Subject RIV: AH - Economics Impact factor: 0.363, year: 2006

  14. Online Mendelian Inheritance in Man (OMIM).

    Science.gov (United States)

    Hamosh, A; Scott, A F; Amberger, J; Valle, D; McKusick, V A

    2000-01-01

    Online Mendelian Inheritance In Man (OMIM) is a public database of bibliographic information about human genes and genetic disorders. Begun by Dr. Victor McKusick as the authoritative reference Mendelian Inheritance in Man, it is now distributed electronically by the National Center for Biotechnology Information (NCBI). Material in OMIM is derived from the biomedical literature and is written by Dr. McKusick and his colleagues at Johns Hopkins University and elsewhere. Each OMIM entry has a full text summary of a genetic phenotype and/or gene and has copious links to other genetic resources such as DNA and protein sequence, PubMed references, mutation databases, approved gene nomenclature, and more. In addition, NCBI's neighboring feature allows users to identify related articles from PubMed selected on the basis of key words in the OMIM entry. Through its many features, OMIM is increasingly becoming a major gateway for clinicians, students, and basic researchers to the ever-growing literature and resources of human genetics. Copyright 2000 Wiley-Liss, Inc.

  15. Pet Therapy: Man's Best Friend as Healer

    Science.gov (United States)

    ... psychological and physiological health of critically ill patients. Dimensions of Critical Care Nursing. 2010;29:211. Cangelosi PR, et al. Walking for therapy with man's best friend. Journal of Psychosocial Nursing and Mental ...

  16. Biodistribution and metabolism of the anti-influenza drug [{sup 11}C]oseltamivir and its active metabolite [{sup 11}C]Ro 64-0802 in mice

    Energy Technology Data Exchange (ETDEWEB)

    Hatori, Akiko; Arai, Takuya; Yanamoto, Kazuhiko; Yamasaki, Tomoteru; Kawamura, Kazunori; Yui, Joji; Konno, Fujiko; Nakao, Ryuji; Suzuki, Kazutoshi [Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555 (Japan); Zhang Mingrong [Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555 (Japan)], E-mail: zhang@nirs.go.jp

    2009-01-15

    Introduction: Oseltamivir phosphate (Tamiflu) is an orally active anti-influenza drug, which is hydrolyzed by esterase to its carboxylate metabolite Ro 64-0802 with potent activity to inhibit the influenza virus. The abnormal behavior and death associated with the use of oseltamivir have developed into a major problem in Japan where Tamiflu is often prescribed for seasonal influenza. It is critical to determine the amount of oseltamivir and Ro 64-0802 in the human brain and to elucidate the relationship between their amounts and neuropsychiatric side effects. The aim of this study was to evaluate [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in mice as promising positron emission tomography (PET) ligands for measuring their amounts in living brains. Methods: Whole-body biodistribution of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 was determined in mice using the dissection method and micro-PET. In vitro and in vivo metabolite assay was performed in the plasma and brain of mice. Results: Between 1 and 60 min after injection of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802, 0.20-0.06% and 0.39-0.03% ID/g were detected in the mouse brains, respectively (dissection method). Radioactivity concentrations in the living brains between 0 and 90 min after injection were measured at standardized uptake values of 0.25-0.05 for [{sup 11}C]oseltamivir and 0.38-0.02 for [{sup 11}C]Ro 64-0802 (micro-PET). In vivo metabolite assay demonstrated the presence of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in the brains after [{sup 11}C]oseltamivir injection. Conclusion: This study determined the distribution and metabolism of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in mice. PET could be used to measure their amounts in the living brain and to elucidate the relationship between the amounts in the brain and the side effects of Tamiflu in the central nervous system.

  17. Graham Greene and Cuba: Our man in Havana?

    Directory of Open Access Journals (Sweden)

    Peter Hulme

    2008-12-01

    Full Text Available [First paragraph] Graham Greene’s novel Our Man in Havana was published on October 6, 1958. Seven days later Greene arrived in Havana with Carol Reed to arrange for the filming of the script of the novel, on which they had both been working. Meanwhile, after his defeat of the summer offensive mounted by the Cuban dictator, Fulgencio Batista, in the mountains of eastern Cuba, just south of Bayamo, Fidel Castro had recently taken the military initiative: the day after Greene and Reed’s arrival on the island, Che Guevara reached Las Villas, moving westwards towards Havana. Six weeks later, on January 1, 1959, after Batista had fled the island, Castro and his Cuban Revolution took power. In April 1959 Greene and Reed were back in Havana with a film crew to film Our Man in Havana. The film was released in January 1960. A note at the beginning of the film says that it is “set before the recent revolution.” In terms of timing, Our Man in Havana could therefore hardly be more closely associated with the triumph of the Cuban Revolution. But is that association merely accidental, or does it involve any deeper implications? On the fiftieth anniversary of novel, film, and Revolution, that seems a question worth investigating, not with a view to turning Our Man in Havana into a serious political novel, but rather to exploring the complexities of the genre of comedy thriller and to bringing back into view some of the local contexts which might be less visible now than they were when the novel was published and the film released.

  18. Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET

    International Nuclear Information System (INIS)

    Pappata, S.; Samson, Y.; Chavoix, C.; Prenant, C.; Maziere, M.; Baron, J.C.

    1988-01-01

    The central type benzodiazepine receptors were studied in 17 healthy human subjects with 11 C-RO 15 1788 and positron emission tomography (PET). The brain regional distribution of the tracer in eight control studies performed after injection of trace doses of 11 C-RO 15 1788 was consistent with that of benzodiazepine receptors. Saturation studies with co-injected cold RO 15 1788 in the remaining subjects showed a dose-dependent decrease of brain radiotracer until full inhibition of specific binding was achieved with doses above 0.1 mg/kg (four studies). Based on the results, a simple method to estimate the specifically bound 11 C-RO 15 1788 regionally in a single PET study is proposed, using the data from the full-saturation studies as a stable estimate of the nondisplaceable radioligand concentration. Using this method, it was found that quasiequilibrium between the estimated specifically bound and nondisplaceable components was achieved at times equal to or longer than 20 min after tracer administration. The validity of this method was partly supported by further results, showing a good agreement between the regional specific binding so calculated and postmortem data of receptor density

  19. Effects of dose, species, and dosing vehicle on the disposition of methacrylonitrile (MAN) in male rats

    International Nuclear Information System (INIS)

    Sanchez, I.M.; Ghanayem, B.I.

    1991-01-01

    MAN is structurally similar to known carcinogen acrylontrile (AN), with nitriles having similar industrial uses. Current studies were designed to investigate the biological fate of 2- 14 C-MAN in rats. After gavage administration of 115, 11.5 or 1.15 mg MAN/kg in water, F344 male rats were placed in glass metabolism cages and urine, expired air and feces were collected. Rats were sacrificed at various times and concentration of MAN-derived radioactivity in tissues was determined. MAN was rapidly absorbed from the GI tract and distributed to all major tissues. Sixty-70% of the low and medium doses were exhaled as 14 CO 2 in 72 hr compared to 25% of the highest dose. While 40% of the highest dose was expired as organic volatiles in 72 hr, only 9-12% of the low and accounted for 20-30% of all doses within 72 hr after dosing. Comparison of MAN disposition in Sprague-Dawley (SD) and F344 rats at 115 mg/kg revealed that SD rats excreted a greater % of the dose as 14 CO 2 and in the urine than did F344 rats. Administration of 115 mg MAN/kg to SD male rats in safflower oil resulted in increased elimination of MAN-derived radioactivity as CO 2 , volatiles, and in the urine over that observed when administered in water. These results suggest that: (1) saturation of MAN metabolism occurs at high doses: (2) MAN metabolism and disposition differ with the strain of rats studied; (3) MAN disposition may vary with the dosing vehicle used; and (4) MAN metabolism and disposition is apparently different from that reported on AN

  20. Why Cannot Today’s Medicine Tolerate Man?

    Directory of Open Access Journals (Sweden)

    Farzad Goli

    2017-08-01

    Full Text Available Today, anyone who has travelled a little through history or reflected on social systems knows that although social systems are established and designed to satisfy our needs and demands, they have needs of their own which guarantee their life and may precede our needs. Hence, these systems, which were supposed to serve us indisputably like the genie, make us serve them in different ways. Medicine is one of such social systems which were undoubtedly established to satisfy our vital need to care and cure. To exist and develop, medicine needs to know and control personal and social conditions, and to actualize this need, it needs knowledge, money, and, perhaps prior to all of these, it needs to be trusted. To know man, he should be completely uncovered, observable, and dissected into his parts and the relationship between his parts should be explained in simple models. And to direct the condition toward maximum health, men should be converted into statistical entities and their individual differences, conditions, and narratives have to be ignored so that they become predictable and, consequently, controllable creatures. The story of relative, and almost necessary, conflict between man and medicine is as simple as it is explained. Before we go any further into the discussion, we should remember that a real man, with his whole phenomenological world and new-emergent and unique properties of autonomy and consciousness, may suddenly behave like a joker and disturb all the rules of medicine's play. It is natural that such subtleties cannot be tolerated by a materialistic model which is relying on knowledge of mechanistic organization of parts. The aim of this theoretical essay was to increase the readers’ awareness of biomedical model restrictions and organized cruelties it imposes on man in practice and theory. The discussion of alternate models which we are turning to recently has been undertaken in other essays.