WorldWideScience

Sample records for ykl-40 casa ca

  1. Pre-treatment prediction of chemoresistance in second-line chemotherapy of ovarian carcinoma: value of serological tumor marker determination (tetranectin, YKL-40, CASA, CA 125)

    DEFF Research Database (Denmark)

    Grønlund, B; Høgdall, E V S; Christensen, Ib Jarle

    2006-01-01

    for the biochemical tumor markers tetranectin, YKL-40, CASA (cancer-associated serum antigen), and CA 125. The serum tumor marker levels at time of relapse were correlated with response status at landmark time after 4 cycles of second-line chemotherapy. Univariate and multivariate logistic regression analyses...... (OR 1.8; 95% CI: 1.0-3.3; p=0.045), and CASA (OR 1.8; 95% CI: 1.2-2.7; p=0.007) had predictive value for second-line chemoresistance, whereas serum CA 125 had no predictive value. In a multivariate logistic regression analysis, serum tetranectin and CASA both had independent predictive value...... for chemoresistance. The combined determination of tetranectin and CASA had a specificity of 90% with 33% sensitivity for the prediction of chemoresistance (area under the receiver operating characteristic curve = 0.78; 95% CI: 0.66-0.91; p=0.001). CONCLUSION: Low serum levels of tetranectin, or high serum levels...

  2. Plasma YKL-40

    DEFF Research Database (Denmark)

    Jensen, Peter; Wiell, C; Milting, K

    2013-01-01

    Background  Plasma YKL-40 is an inflammatory biomarker. No useful biomarker exists in patients with psoriasis or psoriatic arthritis. Objective  To measure YKL-40 and high-sensitivity C-reactive protein (hs-CRP) in patients with psoriasis or psoriatic arthritis before and during treatment. Methods......-CRP at inclusion and during 48 weeks of adalimumab treatment. The patients with psoriatic arthritis were divided into responders and non-responders. Results  In patients with psoriasis, the baseline median PASI score was 10.8 and baseline YKL-40 was 45 μg/L. Seventeen per cent had elevated plasma YKL-40 compared...

  3. Serum YKL-40

    DEFF Research Database (Denmark)

    Mylin, Anne K; Abildgaard, Niels; Johansen, Julia S

    2015-01-01

    to clinical progression, i.e. skeletal-related events (SREs), in 230 newly diagnosed patients with multiple myeloma receiving intravenous bisphosphonates. Serum concentrations of YKL-40 and biochemical bone markers (CTX-MMP, CTX-I, PINP) were measured at diagnosis. Patients were evaluated every third month...

  4. YKL-40 tissue expression and plasma levels in patients with ovarian cancer

    International Nuclear Information System (INIS)

    Høgdall, Estrid VS; Christensen, Lise H; Ringsholt, Merete; Høgdall, Claus K; Christensen, Ib Jarle; Johansen, Julia S; Kjaer, Susanne K; Blaakaer, Jan; Ostenfeld-Møller, Lene; Price, Paul A

    2009-01-01

    YKL-40 (chitinase-3-like-1) is a member of 'mammalian chitinase-like proteins'. The protein is expressed in many types of cancer cells and the highest plasma YKL-40 levels have been found in patients with metastatic disease, short recurrence/progression-free intervals, and short overall survival. The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker. YKL-40 protein expression was determined by immunohistochemistry in tissue arrays from 181 borderline tumors and 473 OC. Plasma YKL-40 was determined by ELISA in preoperative samples from 19 patients with borderline tumor and 76 OC patients. YKL-40 protein expression was found in cancer cells, tumor associated macrophages, neutrophils and mast cells. The tumor cell expression was higher in OC than in borderline tumors (p = 0.001), and associated with FIGO stage (p < 0.0001) and histological subtype (p = 0.0009). Positive YKL-40 expression (≥ 5% staining) was not associated with reduced survival. Plasma YKL-40 was also higher in patients with OC than in patients with borderline tumors (p < 0.0001), and it was positively correlated to serum CA-125 (p < 0.0001) and FIGO stage (p = 0.0001). Univariate Cox analysis of plasma YKL-40 showed association with overall survival (p < 0.0001). Multivariate Cox analysis, including plasma YKL-40, serum CA125, FIGO stage, age and radicality after primary surgery as variables, showed that elevated plasma YKL-40 was associated with a shorter survival (HR = 2.13, 95% CI: 1.40–3.25, p = 0.0004). YKL-40 in OC tissue and plasma are related to stage and histology, but only plasma YKL-40 is a prognostic biomarker in patients with OC

  5. Antibody directed against human YKL-40 increases tumor volume in a human melanoma xenograft model in scid mice

    DEFF Research Database (Denmark)

    Salamon, Johannes; Hoffmann, Tatjana; Elies, Eva

    2014-01-01

    were treated with intraperitoneal injections of anti-YKL-40, isoptype control or PBS. Non-YKL-40 expressing human pancreatic carcinoma cell line PaCa 5061 served as additional control. MR imaging was used for evaluation of tumor growth. Two days after the first injections of anti-YKL-40, tumor volume...... had increased significantly compared with controls, whereas no effects were observed for control tumors from PaCa 5061 cells lacking YKL-40 expression. After 18 days, mean tumor size of the mice receiving repeated anti-YKL-40 injections was 1.82 g, >4 times higher than mean tumor size of the controls...

  6. Serum YKL-40 and colorectal cancer

    DEFF Research Database (Denmark)

    Cintin, C; Johansen, J S; Christensen, Ib Jarle

    1999-01-01

    related to short survival. In the present study we analysed YKL-40 in preoperative sera from patients with colorectal cancer and evaluated its relation to survival. Serum YKL-40 was determined by RIA in 603 patients. Survival after operation was registered, and median follow-up time was 61 months. Three......YKL-40 is a mammalian member of the chitinase protein family. Although the function of YKL-40 is unknown, the pattern of its expression suggests a function in remodelling or degradation of extracellular matrix. High serum YKL-40 has been found in patients with recurrent breast cancer and has been...

  7. Serum YKL-40 and colorectal cancer

    DEFF Research Database (Denmark)

    Cintin, C; Johansen, J S; Christensen, Ib Jarle

    1999-01-01

    related to short survival. In the present study we analysed YKL-40 in preoperative sera from patients with colorectal cancer and evaluated its relation to survival. Serum YKL-40 was determined by RIA in 603 patients. Survival after operation was registered, and median follow-up time was 61 months. Three...

  8. Plasma YKL-40 in Inuit and Danes.

    Science.gov (United States)

    Nøjgaard, Camilla; Johansen, Julia S; Bjerregaard, Peter; Bojesen, Stig E; Becker, Ulrik

    2015-01-01

    The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit. Plasma YKL-40 levels were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general population). The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10-2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20-2827, n = 481) and of Danes living in Denmark (median 55 µg/l, range 10-2909, n = 8899). In Inuit, increased alcohol intake was significantly associated with increased plasma YKL-40 levels (P Inuit living in Greenland than Inuit and Danes living in Denmark. A number of factors, including different alcohol intake patterns, nutrition and genes may play a role in these findings. © The Author 2014. Medical Council on Alcohol and Oxford University Press. All rights reserved.

  9. YKL-40 protein in osteosarcoma tumor tissue

    DEFF Research Database (Denmark)

    Thorn, Andrea Pohly; Daugaard, Søren; Christensen, Lise Hanne

    2016-01-01

    YKL-40, a cellular glycoprotein isolated from the human osteosarcoma (OS) cell line MG63, is increased in the blood of patients with various types of cancer, and is found as an independent prognostic variable for survival. YKL-40 is also present with variable intensity in the tumor cells of some...... cancer types, but survival results have been conflicting. The aim of this study was to investigate the tissue expression of YKL-40 and its possible role as a predictive marker in patients with OS. Forty-eight patients were included in the study. Diagnostic biopsies were analyzed by immunohistochemistry...

  10. Plasma YKL-40 in Inuit and Danes

    DEFF Research Database (Denmark)

    Nøjgaard, Camilla; Johansen, Julia S; Bjerregaard, Peter

    2015-01-01

    AIMS: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit. METHODS: Plasma YKL-40 levels...... were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general...... population). RESULTS: The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10-2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20-2827, n = 481) and of Danes living in Denmark...

  11. Overexpression of chitinase like protein YKL-40 in leukemia patients

    Directory of Open Access Journals (Sweden)

    Anil K. Hurmale

    2013-01-01

    Full Text Available YKL-40 is a member of mammalian chitanase (CHI3L1, expressed and secreted by several types of solid tumor cells, inflammatory cells and stem cells. The precise physiological role of YKL-40 in cancer is still not clear and it is suggested that it play a role in cancer cell proliferation, differentiation, metastatic potential, cell attachment and migration, reorganization and tissue remodeling.The aim of the study was to check the appearance of YKL-40 in leukemic cells and over-expression of YKL-40 in the plasma of leukemia patients in comparison to healthy controls, and find whether YKL-40 could serve as a peripheral biomarker for leukemia. The study was conducted between July 2012 and March 2013 and included 67 volunteers, 55 having leukemia at the stage of diagnosis ofthe disease and 12 normal healthy volunteers. YKL-40 levels were determined in all plasma samples using the YKL-40 enzyme-linked immunosorbent assay (ELISA kit and expression of YKL-40 was observed by using immunocytochemical (ICC analysis. YKL-40 plasma levels differed significantly between patients with leukemia and the normal healthy volunteers (P=<0.001 and YKL-40 was positively expressed in all four types of leukemia (AML, ALL, CLL and CML specimens.

  12. Serum YKL-40 is increased in patients with hepatic fibrosis

    DEFF Research Database (Denmark)

    Johansen, J S; Christoffersen, P; Møller, S

    2000-01-01

    BACKGROUND/AIMS: YKL-40, a mammalian member of the chitinase family, is a lectin that binds heparin and chitin. The function of YKL-40 is unknown, but it may function in tissue remodelling. The aims of this study were to assess the level of circulating YKL-40 in patients with various kinds...... with the blood sample. RESULTS: The median serum YKL-40 was highest in patients with alcoholic cirrhosis (532 microg/l), in particular in patients with additional alcoholic hepatitis (740 microg/l). Patients with alcoholic cirrhosis, post-hepatitic cirrhosis (425 microg/l) and non-cirrhotic fibrosis (330 microg/l......) had significantly higher serum YKL-40 than normal subjects (102 microg/l), patients with fatty liver (195 microg/l) or patients with viral hepatitis without fibrosis (174 microg/l). Serum YKL-40 was significantly (p

  13. Plasma YKL-40: a potential new cancer biomarker?

    DEFF Research Database (Denmark)

    Johansen, Julia S; Schultz, Nicolai A; Jensen, Benny V

    2009-01-01

    tissue remodeling. Plasma levels of YKL-40 are elevated in a subgroup of patients with primary or advanced cancer compared with age-matched healthy subjects, but also in patients with many different diseases characterized by inflammation. Elevated plasma YKL-40 levels are an independent prognostic...... by inflammation. Large prospective, longitudinal clinical cancer studies are needed to determine if plasma YKL-40 is a new cancer biomarker, or is mainly a biomarker of inflammation....

  14. YKL-40 - an emerging biomarker in cardiovascular disease and diabetes

    Directory of Open Access Journals (Sweden)

    Rathcke Camilla

    2009-01-01

    Full Text Available Abstract Several inflammatory cytokines are involved in vascular inflammation resulting in endothelial dysfunction which is the earliest event in the atherosclerotic process leading to manifest cardiovascular disease. YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction by promoting chemotaxis, cell attachment and migration, reorganization and tissue remodelling as a response to endothelial damage. YKL-40 protein expression is seen in macrophages and smooth muscle cells in atherosclerotic plaques with the highest expression seen in macrophages in the early lesion of atherosclerosis. Several studies demonstrate, that elevated serum YKL-levels are independently associated with the presence and extent of coronary artery disease and even higher YKL-40 levels are documented in patients with myocardial infarction. Moreover, elevated serum YKL-40 levels have also been found to be associated with all-cause as well as cardiovascular mortality. Finally, YKL-40 levels are elevated both in patients with type 1 and type 2 diabetes, known to be at high risk for the development of cardiovascular diseases, when compared to non-diabetic persons. A positive association between elevated circulating YKL-40 levels and increasing levels of albuminuria have been described in patients with type 1 diabetes indicating a role of YKL-40 in the progressing vascular damage resulting in microvascular disease. This review describes the present knowledge about YKL-40 and discusses its relation to endothelial dysfunction, atherosclerosis, cardiovascular disease and diabetes and look ahead on future perspectives of YKL-40 research.

  15. Plasma YKL-40 during pregnancy and gestational diabetes mellitus

    DEFF Research Database (Denmark)

    Rinnov, Anders R; Rathcke, Camilla N; Bonde, Lisbeth

    2015-01-01

    in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM...... and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups...

  16. Increased YKL-40 expression in patients with carotid atherosclerosis

    DEFF Research Database (Denmark)

    Michelsen, Axel Gottlieb; Rathcke, C.N.; Skjelland, M.

    2010-01-01

    atherosclerosis and 20 healthy controls. Carotid expression of YKL-40 was examined by real time RT-PCR in 57 of the patients. Regulation and effect of YKL-40 were examined in THP-1 monocytes. Results: Our main findings were: (1) serum YKL-40 levels were significantly elevated in patients with carotid...... atherosclerosis, with particularly high levels in those with symptomatic disease; (2) patients with recent ischemic symptoms (within 2 months) had higher YKL-40 mRNA levels in carotid plaque than other patients; (3) in vitro, the beta-adrenergic receptor agonist isoproterenol, toll-like receptor (TLR) 2 and TLR4...

  17. Serum YKL-40 and gestational diabetes - an observational cohort study

    DEFF Research Database (Denmark)

    Gybel-Brask, Dorte; Johansen, Julia S; Christiansen, Ib J

    2016-01-01

    To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical...... records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40...

  18. Study of serum YKL-40 in children with bronchial

    Directory of Open Access Journals (Sweden)

    Iman A. Mohammed

    2016-03-01

    Conclusions: Serum YKL-40 protein was found in increased quantities in patients with asthma in whom the protein level correlated positively with the severity of disease so our data concluded that YKL-40 could be a valuable biomarker for asthma diagnosis and prognosis.

  19. Plasma YKL-40 during pregnancy and gestational diabetes mellitus.

    Science.gov (United States)

    Rinnov, Anders R; Rathcke, Camilla N; Bonde, Lisbeth; Vilsbøll, Tina; Knop, Filip K

    2015-11-01

    Gestational diabetes mellitus (GDM) is characterised by hyperglycaemia during pregnancy. The clinical circumstances involved in the development of GDM leaves the patient at a high risk of the subsequent development of type 2 diabetes. Plasma levels of the inflammation marker YKL-40 are elevated in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups and increased significantly after delivery, but remained lower in the GDM group compared with the non-GDM group postpartum. In contrast, plasma IL-6 levels were not affected by pregnancy or diagnosis of GDM, Nevertheless, YKL-40 levels were associated with IL-6 levels in the non-GDM group (but not in the GDM group). Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Genetic and epigenetic regulation of YKL-40 in childhood.

    Science.gov (United States)

    Guerra, Stefano; Melén, Erik; Sunyer, Jordi; Xu, Cheng-Jian; Lavi, Iris; Benet, Marta; Bustamante, Mariona; Carsin, Anne-Elie; Dobaño, Carlota; Guxens, Mònica; Tischer, Christina; Vrijheid, Martine; Kull, Inger; Bergström, Anna; Kumar, Ashish; Söderhäll, Cilla; Gehring, Ulrike; Dijkstra, Dorieke J; van der Vlies, Pieter; Wickman, Magnus; Bousquet, Jean; Postma, Dirkje S; Anto, Josep M; Koppelman, Gerard H

    2018-03-01

    Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several diseases, including asthma. Epigenetic regulation of circulating YKL-40 early in life is unknown. We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-40 levels in the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) are associated with asthma in early childhood. We used data from up to 2405 participants from the Spanish Infancia y Medio Ambiente; the Swedish Barn/Children, Allergy, Milieu, Stockholm, Epidemiological survey; and the Dutch Prevention and Incidence of Asthma and Mite Allergy birth cohorts. Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL-40 levels at 4 years of age were tested by using correlation analysis, multivariable regression, and mediation analysis. Each of these biomarkers was also tested for association with asthma at 4 years of age by using multivariable logistic regression. YKL-40 levels were significantly associated with 7 SNPs and with methylation at 5 CpG sites. Consistent associations between these 7 SNPs (particularly rs10399931 and rs4950928) and 5 CpG sites were observed. Alleles linked to lower YKL-40 levels were associated with higher methylation levels. Participants with high YKL-40 levels (defined as the highest YKL-40 tertile) had increased odds for asthma compared with subjects with low YKL-40 levels (meta-analyzed adjusted odds ratio, 1.90 [95% CI, 1.08-3.36]). In contrast, neither SNPs nor methylation levels at CpG sites in CHI3L1 were associated with asthma. The effects of CHI3L1 genetic variation on circulating YKL-40 levels are partly mediated by methylation profiles. In our study YKL-40 levels, but not CHI3L1 SNPs or

  1. Plasma YKL-40, a new biomarker for atrial fibrillation?

    DEFF Research Database (Denmark)

    Henningsen, Kristoffer Mads; Therkelsen, Susette Krohn; Johansen, Julia Sidenius

    2009-01-01

    AIMS: The aim of this study was to determine changes in a new potential biomarker plasma YKL-40 in patients with atrial fibrillation (AF) before and after electrical cardioversion (CV). METHODS AND RESULTS: Plasma concentrations of YKL-40 were measured in 56 patients (mean age 65 years, range 34......-84) with persistent AF (lasting mean 128 days, range 14-960), in 19 age-matched patients with permanent AF, and in 19 healthy subjects. The patients with persistent AF underwent CV. Plasma YKL-40 was measured prior to CV, and at follow-up after 24 h, 30 and 180 days. Patients with persistent AF had lower plasma YKL...

  2. Serum YKL-40 in risk assessment for colorectal cancer

    DEFF Research Database (Denmark)

    Johansen, Julia Sidenius; Christensen, Ib Jarle; Jørgensen, Lars Nannestad

    2015-01-01

    The aim of the present study was to test the hypothesis that high serum YKL-40 associates with colorectal cancer in subjects at risk of colorectal cancer. We measured serum YKL-40 in a prospective study of 4,496 Danish subjects [2,064 men, 2,432 women, median age 61 years (range, 18-97)] referred.......05-1.40; P = 0.012), whereas this was not the case for those with comorbidity (OR, 0.98; 95% CI, 0.84-1.14; P = 0.80). In conclusion, high serum YKL-40 in subjects suspected of colorectal cancer and without comorbidity associates with colorectal cancer. Determination of serum YKL-40 may be useful...

  3. YKL-40--an emerging biomarker in cardiovascular disease and diabetes

    DEFF Research Database (Denmark)

    Rathcke, Camilla N; Vestergaard, Henrik

    2009-01-01

    Several inflammatory cytokines are involved in vascular inflammation resulting in endothelial dysfunction which is the earliest event in the atherosclerotic process leading to manifest cardiovascular disease. YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction by promoting....... Several studies demonstrate, that elevated serum YKL-levels are independently associated with the presence and extent of coronary artery disease and even higher YKL-40 levels are documented in patients with myocardial infarction. Moreover, elevated serum YKL-40 levels have also been found to be associated...... with all-cause as well as cardiovascular mortality. Finally, YKL-40 levels are elevated both in patients with type 1 and type 2 diabetes, known to be at high risk for the development of cardiovascular diseases, when compared to non-diabetic persons. A positive association between elevated circulating YKL...

  4. Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast

    DEFF Research Database (Denmark)

    Roslind, A.; Balslev, E.; Kruse, H.

    2008-01-01

    . YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial......YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy...

  5. Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells

    DEFF Research Database (Denmark)

    Junker, Nanna; Johansen, Julia S; Hansen, Lasse T

    2005-01-01

    YKL-40 is a 40 kDa secreted glycoprotein belonging to the family of 'mammalian chitinase-like proteins', but without chitinase activity. YKL-40 has a proliferative effect on fibroblasts, chondrocytes and synoviocytes, and chemotactic effect on endothelium and vascular smooth muscle cells. Elevated...... material from glioblastomas patients. We investigated the expression of YKL-40 in three human malignant glioma cell lines exposed to different types of stress. Whereas a polymerase chain reaction transcript was detectable in all three cell lines, only U87 produced measurable amounts of YKL-40 protein. In U...... is attenuated by p53. In contrast, both basic fibroblast growth factor and tumor necrosing factor-alpha repressed YKL-40. These are the first data on regulation of YKL-40 in cancer cells. Diverse types of stress resulted in YKL-40 elevation, which strongly supports an involvement of YKL-40 in the malignant...

  6. YKL-40 and genetic status of CHI3L1 in a large group of asthmatics

    DEFF Research Database (Denmark)

    Hansen, Jakob W; Thomsen, Simon F; Porsbjerg, Celeste

    2015-01-01

    BACKGROUND: Studies have shown a relationship between asthma, serum YKL-40, and the single nucleotide polymorphism (SNP) (-131 C/G, rs4950928) in the CHI3L1 gene that codes for YKL-40. However, the findings differ. We studied the relationship between clinical asthma phenotypes, serum YKL-40...... to clarify the relationship between different asthma phenotypes, YKL-40, and CHI3L1....

  7. Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

    DEFF Research Database (Denmark)

    Johansen, Julia S; Milman, Nils; Hansen, Michael

    2005-01-01

    YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant...... cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity....

  8. Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40

    DEFF Research Database (Denmark)

    Aziz, M; Wissing, M L M; Naver, K V

    2014-01-01

    OBJECTIVE: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids......, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40. CONCLUSION: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS....

  9. Increased Levels of YKL-40 and Interleukin 6 in Patients With Chronic Pancreatitis and Secondary Diabetes

    DEFF Research Database (Denmark)

    Hansen, Morten; Nielsen, Anders Rinnov; Vilsbøll, Tina

    2012-01-01

    Circulating levels of YKL-40 and interleukin 6 (IL-6) are elevated in patients with type 2 diabetes. We aimed to evaluate YKL-40 levels in patients with chronic pancreatitis (CP) with and without secondary diabetes mellitus (DM) to investigate whether elevated plasma YKL-40 could play a primary...

  10. Increased serum YKL-40 in patients with pulmonary sarcoidosis—a potential marker of disease activity?

    DEFF Research Database (Denmark)

    Johansen, JS; Milman, N; Hansen, M

    2005-01-01

    macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity. Methods: Serum YKL-40 was determined by radioimmunoassay in 27 patients with a histological...

  11. Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer

    DEFF Research Database (Denmark)

    Junker, Nanna; Johansen, Julia S; Andersen, Claus B

    2005-01-01

    YKL-40 is a 40 kDa protein with possible involvement in tissue remodeling, cell proliferation and angiogenesis. Elevated serum YKL-40 levels in patients with metastatic cancers (including small cell lung cancer (SCLC)) are associated with poor prognosis. The aim of this study was to identify...... the cellular source of YKL-40 in SCLC patient biopsies and in a panel of 20 human SCLC lines cultured in vitro and in vivo in nude mice. In general, the SCLC cell lines had no or very limited (human) YKL-40 expression, whereas, by RT-PCR a pronounced murine (i.e., stromal) YKL-40 expression was present in all...

  12. YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer

    DEFF Research Database (Denmark)

    Roslind, Anne; Knoop, Ann; Jensen, Maj-Britt

    2007-01-01

    in tumor tissue was assessed by immunohistochemistry in a cohort of 630 high-risk breast cancer patients with a median estimated potential follow-up time of 10 and 13 years for disease-free (DFS) and overall survival (OS), respectively. YKL-40 protein expression was found in malignant tumor cells......YKL-40 is a new biomarker in serum with a prognostic value in several localized and metastatic malignancies. The current knowledge regarding the biological functions of YKL-40 in cancer links YKL-40 to increased aggressiveness of the tumor. Utilizing tissue microarrays, YKL-40 protein expression...... and in inflammatory cells. High expression was associated with positive estrogen and progesterone receptor status and high tumor differentiation. Contrary to studies on serum YKL-40 as a prognostic biomarker, a high YKL-40 expression in tumor cells was not significantly associated with DSF and OS in univariate...

  13. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis

    DEFF Research Database (Denmark)

    Ostergaard, C; Johansen, JS; Benfield, Thomas

    2002-01-01

    -Whitney test, P = 0.018). YKL-40 was most likely locally produced, since patients with infections of the central nervous system had CSF YKL-40 levels that were at least 10-fold higher than the corresponding levels in serum (2,033 microg/liter [470 to 11,600] versus 80 microg/liter [19 to 195]). The CSF...... neopterin level was the biochemical parameter in CSF and blood that correlated best with CSF YKL-40 levels, indicating that YKL-40 may be produced by activated macrophages within the central nervous system. In conclusion, high levels of YKL-40 in CSF are found in patients with purulent meningitis.......YKL-40, a member of the family 18 glycosyl hydrolases, is secreted by activated neutrophils and macrophages. It is a growth factor for connective tissue cells and a potent migration factor for endothelial cells and may function in inflammation and tissue remodeling. YKL-40 was determined in 134...

  14. YKL-40 tissue expression and plasma levels in patients with ovarian cancer

    DEFF Research Database (Denmark)

    Høgdall, Estrid V S; Ringsholt, Merete; Høgdall, Claus K

    2009-01-01

    survival. The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker. METHODS: YKL-40 protein expression was determined by immunohistochemistry...... in tissue arrays from 181 borderline tumors and 473 OC. Plasma YKL-40 was determined by ELISA in preoperative samples from 19 patients with borderline tumor and 76 OC patients. RESULTS: YKL-40 protein expression was found in cancer cells, tumor associated macrophages, neutrophils and mast cells. The tumor...... stage, age and radicality after primary surgery as variables, showed that elevated plasma YKL-40 was associated with a shorter survival (HR = 2.13, 95% CI: 1.40-3.25, p = 0.0004). CONCLUSION: YKL-40 in OC tissue and plasma are related to stage and histology, but only plasma YKL-40 is a prognostic...

  15. YKL-40 levels are independently associated with albuminuria in type 2 diabetes

    DEFF Research Database (Denmark)

    Røndbjerg, Anne K; Omerovic, Emina; Vestergaard, Henrik

    2011-01-01

    YKL-40 is involved in inflammation and endothelial dysfunction, and is increased in patients with type 1 diabetes, with an independent association between increasing YKL-40 levels and increasing levels of albuminuria. YKL-40 is associated with atherosclerosis and an increased cardiovascular morta...... mortality in the general population. In the present study YKL-40 levels were examined in patients with type 2 diabetes (T2D) with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease.......YKL-40 is involved in inflammation and endothelial dysfunction, and is increased in patients with type 1 diabetes, with an independent association between increasing YKL-40 levels and increasing levels of albuminuria. YKL-40 is associated with atherosclerosis and an increased cardiovascular...

  16. High YKL-40 serum concentration is correlated with prognosis of Chinese patients with breast cancer.

    Directory of Open Access Journals (Sweden)

    Dong Wang

    Full Text Available This study aimed to investigate the association between serum YKL-40 and prognosis of breast cancer in a Chinese population. Expression of YKL-40 of 120 Chinese patients with breast cancer and 30 controls (benign breast lesions was measured in tumor tissue by immunohistochemistry and in serum by ELISA. Differences in YKL-40 positivity grouped by specific patients' characteristics were compared using Pearson Chi-square test for rates of intratumoral staining, one-way ANOVA with a Bonferroni post-hoc comparison, or two-sample t-test for mean YKL-40 serum concentrations. Factors associated with overall survival were identified by univariate and multivariate cox-regression analyses. YKL-40 was elevated in approximately 75% of Chinese patients with breast cancer. A significantly higher percentage of patients with YKL-40 positive tumors had larger tumor size, higher TNM stage, and/or lymph node metastasis. Significantly higher mean YKL-40 serum concentrations were observed in patient subgroups with invasive lobular carcinoma (P<0.0167, higher TNM stage (P<0.001, and positive lymph node metastasis (P<0.001. The estimated mean survival time of patients with YKL-40 positive tumors was significantly shorter than for patients with YKL-40 negative tumors (55.13 months vs 65.78 months, P = 0.017. Multivariable Cox-regression analysis identified a significant association of overall survival time with YKL-40 serum concentration. Patients with YKL-40 positive tumors had significantly shorter disease free survival times than those with YKL-40 negative tumors. We propose that the potential utility of YKL-40 intratumoral staining or serum concentration as a biomarker for breast cancer is greatest within 5 years of diagnosis.

  17. The distribution of YKL-40 in osteoarthritic and normal human articular cartilage

    DEFF Research Database (Denmark)

    Volck, B; Ostergaard, K; Johansen, J S

    1999-01-01

    YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL......-40 in osteoarthritic (n=9) and macroscopically normal (n=5) human articular cartilage, collected from 12 pre-selected areas of the femoral head, to discover a potential role for YKL-40 in cartilage remodelling in osteoarthritis. Immunohistochemical analysis showed that YKL-40 staining was found...... in chondrocytes of osteoarthritic cartilage mainly in the superficial and middle zone of the cartilage rather than the deep zone. There was a tendency for high number of YKL-40 positive chondrocytes in areas of the femoral head with a considerable biomechanical load. The number of chondrocytes with a positive...

  18. SERUM YKL-40 CORRELATES WITH SERUM INTERLEUKIN-6 IN MULTIPLE MYELOMA

    DEFF Research Database (Denmark)

    Mylin, Anne Kjærsgaard; Andersen, Niels Frost; Johansen, Julia S.

    2007-01-01

    Introduction. The secreted glycoprotein YKL-40 (CHI3L1, HC gp-39) is a potential player in the tumor-host interactions affecting several aspects of multiple myeloma (MM) including angiogenesis. YKL-40 expression is seeen in vascular smooth muscle cells, and the protein is suggested to function......, but S-YKL-40 show a strong positive correlation with S-IL-6 consistent with a possible IL-6 mediated regulation of YKL-40 secretion demonstrated in previous studies. Table 1     Normal S-YKL-40 N   Median (range)     Elevated S-YKL-40 N   Median (range)     p-value   S-IL-6, ng/L             PB 23 3 (1...

  19. Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?

    DEFF Research Database (Denmark)

    Johansen, J S; Møller, S; Price, P A

    1997-01-01

    YKL-40 is released or extracted in the hepatosplanchnic system and to localize YKL-40 in liver tissue. METHODS: Plasma YKL-40 was determined by radioimmunoassay in 25 patients with liver diseases (alcoholic cirrhosis (n = 20), chronic active hepatitis (n = 2), cirrhosis of unknown aetiology (n = 2...... with alcoholic liver disease. RESULTS: Plasma YKL-40 was significantly increased in patients with alcoholic cirrhosis (median, 523 micrograms/l; P ... with a moderate or severe degree of liver fibrosis, and immunohistochemical studies showed positive staining for YKL-40 antigen in areas of the liver biopsy with fibrosis. CONCLUSIONS: The increased plasma YKL-40 in patients with alcoholic cirrhosis may reflect the remodelling of liver fibrosis....

  20. YKL-40: a new biomarker in cardiovascular disease?

    DEFF Research Database (Denmark)

    Mathiasen, Anders Bruun; Henningsen, Kristoffer Mads Aaris; Harutyunyan, Marina Jurjevna

    2010-01-01

    Cardiovascular disease in the form of coronary artery disease is the most common cause of death in western countries. Early treatment with stabilizing drugs and mechanical revascularization by percutaneous coronary intervention or coronary bypass surgery has reduced the mortality significantly....... But in spite of improved treatments, many patients are still plagued by a high frequency of angina symptoms, hospitalizations and a poor prognosis. There is a need for new independent or supplementary biomarkers that can help to predict cardiovascular disease and cardiovascular events earlier and more...... precisely, and thus accompany existing biomarkers in both primary and secondary cardiovascular prevention. One such potential new biomarker is the protein YKL-40. As an independent biomarker in both cardiovascular diseases and noncardiovascular diseases, current evidence suggests YKL-40 to be most useful...

  1. Low grade inflammation as measured by levels of YKL-40

    DEFF Research Database (Denmark)

    Rathcke, Camilla Noelle; Raymond, Ilan; Kistorp, Caroline

    2010-01-01

    , increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan...

  2. Serum YKL-40 independently predicts outcome after transcatheter arterial chemoembolization of hepatocellular carcinoma.

    Directory of Open Access Journals (Sweden)

    Cheng-Bao Zhu

    Full Text Available Transcatheter arterial chemoembolization (TACE is the most widely used treatment option for unresectable hepatocellular carcinoma (HCC. Elevated serum YKL-40 level has been shown to predict poor prognosis in HCC patients undergoing resection. This study was designed to validate the prognostic significance of serum YKL-40 in patients with HCC undergoing TACE treatment.Serum YKL-40 level was determined by enzyme-linked immunosorbent assay. Overall survival (OS was evaluated with the Kaplan-Meier method and compared by the log-rank test. Multivariate study with Cox proportional hazard model was used to evaluate independent prognostic variables of OS.The median pretreatment serum YKL-40 in HCC patients with was significantly higher than that in healthy controls (P<0.001. The YKL-40 could predict survival precisely either in a dichotomized or continuous fashion (P<0.001 and P = 0.001, respectively. Multivariate Cox regression analysis indicated that serum YKL-40 was an independent prognostic factor for OS in HCC patients (P = 0.001. In further stratified analyses, YKL-40 could discriminate the outcomes of patients with low and high alpha-fetoprotein (AFP level (P = 0.006 and 0.016, respectively. Furthermore, the combination of serum YKL-40 and AFP had more capacity to predict patients' outcomes.Serum YKL-40 was demonstrated to be an independent prognostic biomarker in HCC patients treated with TACE. Our results need confirmation in an independent study.

  3. Genetic variants in CHI3L1 influencing YKL-40 levels

    DEFF Research Database (Denmark)

    Kjaergaard, Alisa D; Johansen, Julia S; Nordestgaard, Børge G

    2013-01-01

    Despite its important role in many serious diseases, the genetic background for plasma YKL-40 has still not been systematically catalogued. Therefore, we aimed at identifying genetic variants in CHI3L1 influencing plasma YKL-40 levels in the general population.......Despite its important role in many serious diseases, the genetic background for plasma YKL-40 has still not been systematically catalogued. Therefore, we aimed at identifying genetic variants in CHI3L1 influencing plasma YKL-40 levels in the general population....

  4. YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease

    DEFF Research Database (Denmark)

    Wang, Y.Z.; Ripa, R.S.; Johansen, J.S.

    2008-01-01

    Background. YKL-40 is involved in remodelling and angiogenesis in non-cardiac inflammatory diseases. Aim was to quantitate plasma YKL-40 in patients with ST-elevation myocardial infarction (STEMI) or stable chronic coronary artery disease (CAD), and YKL-40 gene activation in human myocardium....... Methods and results. We included 73 patients: I) 20 patients with STEMI; II) 28 patients with stable CAD; III) 15 CAD patients referred for coronary by-pass surgery. YKL-40 mRNA expression was measured in myocardium subtended by stenotic or occluded arteries and areas with no apparent disease; and IV) 10...

  5. YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils

    DEFF Research Database (Denmark)

    Volck, B; Price, P A; Johansen, J S

    1998-01-01

    YKL-40, also called human cartilage glycoprotein-39 (HC gp-39), is a member of family 18 glycosyl hydrolases. YKL-40 is secreted by chondrocytes, synovial cells, and macrophages, and recently it has been reported that YKL-40 has a role as an autoantigen in rheumatoid arthritis (RA). The function...... of patients with RA, and the cells are assumed to play a role in joint destruction in that disorder. Therefore, we examined whether neutrophils are a source of YKL-40. YKL-40 was found to colocalize and comobilize with lactoferrin (the most abundant protein of specific granules) but not with gelatinase...... YKL-40 at the myelocyte-metamyelocyte stage, the stage of maturation at which other specific granule proteins are formed. Assuming that YKL-40 has a role as an autoantigen in RA by inducing T cell-mediated autoimmune response, YKL-40 released from neutrophils in the inflamed joint could be essential...

  6. Role of inflammatory marker YKL-40 in the diagnosis, prognosis and cause of cardiovascular and liver diseases

    DEFF Research Database (Denmark)

    Kjaergaard, A.D.; Johansen, Julia Sidenius; Bojesen, Stig Egil

    2016-01-01

    This review summarizes present evidence for the role of YKL-40 in the diagnosis, prognosis and cause of cardiovascular and alcoholic liver disease. The question of whether YKL-40 is merely a marker or a causal factor in the development of cardiovascular and liver disease is addressed, with emphasis...... of cardiovascular and alcoholic liver disease, thus suggesting that plasma YKL-40 does not play a causal role in the development of these diseases. Despite this, plasma YKL-40 levels may play a role in disease progression after diagnosis, and inhibition of YKL-40 activity might be a novel therapy in some...... rather than a drug and placebo, and like a blinded trial, it allows inference about causality. Moreover, the review also covers background on the molecular biology and functions of YKL-40, YKL-40 levels in healthy individuals and reference range, and the role of YKL-40 as a biomarker of cardiovascular...

  7. Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

    DEFF Research Database (Denmark)

    Bjørnbak, Camilla; Brøchner, Christian B; Larsen, Lars A

    2014-01-01

    and subventricular zones showed specific YKL-40 reactivity confined to pericytes. Furthermore, a population of YKL-40-positive, small, rounded cells was identified in the ventricular and subventricular zones. Real-time quantitative RT-PCR analysis showed strong YKL-40 mRNA expression in the leptomeninges...

  8. Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Holmgaard, Dennis Back; Mygind, Lone; Titlestad, Ingrid Louise

    2013-01-01

    Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains...... unknown. We investigated whether high plasma YKL-40 was associated with increased mortality in patients with moderate to very severe COPD....

  9. Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children.

    Science.gov (United States)

    Kim, Hyun Hee; Chung, Mi Hae; Bin, Joong Hyun; Cho, Kyoung Soon; Lee, Juyoung; Suh, Jin Soon

    2018-01-01

    Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (PUTI was 0.88 for the urinary YKL-40/Cr ratio, 0.86 for pyuria, and 0.71 for positive nitrite on urinalysis. We applied a cut-off value of 125.23 pg/mg to urinary YKL-40/Cr for detecting UTI. Eight of nine children in the control group with pyuria had urinary YKL-40/Cr levels lower than 125.23 pg/mg, and the one child in the UTI group without pyuria or positive nitrite had a urinary YKL-40/Cr level greater than 125.23 pg/mg. Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine. © The Korean Society for Laboratory Medicine

  10. Levels of the inflammation marker YKL-40 in young adults exposed to intrauterine hyperglycemia

    DEFF Research Database (Denmark)

    Kelstrup, Louise; Dejgaard, Thomas F; Clausen, Tine D

    2016-01-01

    Plasma levels of the inflammatory marker YKL-40 were investigated in 597 adult offspring born to women with and without diabetes during pregnancy. No association between fetal exposure to maternal hyperglycemia and levels of YKL-40 was found. However, female sex and increasing BMI in the offspring...

  11. YKL-40 expression in benign and malignant lesions of the breast: a methodologic study

    DEFF Research Database (Denmark)

    Roslind, Anne; Johansen, Julia S; Junker, Nanna

    2007-01-01

    as well as in benign and malignant breast lesions. The presence of YKL-40 in breast tissue was verified by in situ hybridization and protein extraction procedures. An immunohistochemical method was developed and 4 different antibodies directed against YKL-40 were tested. Ten patients with normal breast...

  12. High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement

    DEFF Research Database (Denmark)

    Nordenbaek, C; Johansen, J S; Halberg, P

    2005-01-01

    OBJECTIVES: YKL-40, a growth factor of connective tissue cells, is elevated in sera from patients with diseases characterized by inflammation, tissue remodelling, or fibrosis. The aim of the study was to determine serum YKL-40 levels in patients with systemic sclerosis (SSc) and to explore any po...

  13. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease

    DEFF Research Database (Denmark)

    Nøjgaard, Camilla; Johansen, Julia S; Christensen, Erik

    2003-01-01

    in the patients compared to controls. Patients with steatosis or no fibrosis had the lowest serum levels of YKL-40 and PIIINP, whereas patients with alcoholic hepatitis and/or cirrhosis had the highest levels. Serum YKL-40 was associated with the presence of fibrosis, and serum PIIINP was also associated...

  14. Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children

    Science.gov (United States)

    Kim, Hyun Hee; Chung, Mi Hae; Bin, Joong Hyun; Cho, Kyoung Soon; Lee, Juyoung

    2018-01-01

    Background Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. Methods In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. Results The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (Purinary YKL-40/Cr ratio, 0.86 for pyuria, and 0.71 for positive nitrite on urinalysis. We applied a cut-off value of 125.23 pg/mg to urinary YKL-40/Cr for detecting UTI. Eight of nine children in the control group with pyuria had urinary YKL-40/Cr levels lower than 125.23 pg/mg, and the one child in the UTI group without pyuria or positive nitrite had a urinary YKL-40/Cr level greater than 125.23 pg/mg. Conclusions Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine. PMID:29071817

  15. Plasma YKL-40 levels are elevated in patients with chronic heart failure

    DEFF Research Database (Denmark)

    Rathcke, C.N.; Kistorp, C.; Raymond, I.

    2010-01-01

    . Median YKL-40 levels were approximately 77% higher in patients with CHF (106 (IQR, 66-184) ng/ml vs. 60 (IQR, 42-97) ng/ml, p creatinine ratio (UACR) (beta = 0.12, p = 0.08). YKL-40 levels were not predictive...

  16. SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex

    DEFF Research Database (Denmark)

    Brøchner, Christian B; Møllgård, Kjeld

    2016-01-01

    The glycosphingolipid SSEA-4 and the glycoprotein YKL-40 have both been associated with human embryonic and neural stem cell differentiation. We investigated the distribution of SSEA-4 and YKL-40 positive cells in proliferative zones of human fetal forebrain using immunohistochemistry and double-...

  17. YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation

    DEFF Research Database (Denmark)

    Roslind, Anne; Johansen, Julia S

    2009-01-01

    YKL-40, a member of 'mammalian chitinase-like proteins', is secreted by macrophages, neutrophils, chondrocytes, endothelial-, vascular smooth muscle-, and cancer cells. High serum YKL-40 is a biomarker of poor prognosis in patients with cancer, inflammation and increased tissue remodelling. High...

  18. Plasma YKL-40 and recovery of left ventricular function after acute myocardial infarction

    DEFF Research Database (Denmark)

    Hedegaard, A.; Ripa, Maria Sejersten; Johansen, J.S.

    2010-01-01

    Background: Plasma YKL-40 is increased early in patients with ST-elevation myocardial infarction (STEMI). It is not known whether plasma YKL-40 is related to infarct size and recovery of ventricular function after primary percutaneous coronary intervention (PCI) of STEMI and whether granulocyte...... colony-stimulating factor (G-CSF) therapy influence plasma YKL-40 concentration. Materials and methods: A total of 72 patients (age: 56 +/- 9 years (mean +/- SD), 56 men and 16 women) with STEMI treated with PCI were included in a double-blind, randomized, placebo-controlled trial with subcutaneous G...... to LVEF recovery (p = 0.04) but not infarct size. G-CSF injections increased YKL-40 compared to placebo (p recovery. Conclusion: Plasma YKL-40 was significantly increased in STEMI patients at admission and G-CSF treatment caused a further increase...

  19. High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality

    DEFF Research Database (Denmark)

    Johansen, J. S.; Pedersen, Agnes Nadelmann; Schroll, M.

    2007-01-01

    YKL-40 is secreted by macrophages, neutrophils, chondrocytes, endothelial-, vascular smooth muscle- and cancer cells. Interleukin (IL)-6 stimulates YKL-40 production in human in vivo studies. High serum YKL-40 is associated with poor prognosis in patients with inflammatory diseases and cancer. We...... studied whether serum YKL-40 was associated with systemic low-level inflammation, an immune risk phenotype, and mortality in relatively healthy 80-year old humans. Serum YKL-40, IL-6 and tumour necrosis factor (TNF)-alpha were measured by enzyme-linked immunosorbent assays (ELISAs) in octogenarians (n...

  20. YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers

    DEFF Research Database (Denmark)

    Brøchner, Christian B; Johansen, Julia S; Larsen, Lars A

    2012-01-01

    oxygen tension, in culture medium with or without basic fibroblast growth factor, and on feeder layers comprising mouse embryonic fibroblasts or human foreskin fibroblasts to evaluate whether hESCs and their progeny produced YKL-40 and to characterize YKL-40 expression during differentiation. Secreted......The secreted glycoprotein YKL-40 participates in cell differentiation, inflammation, and cancer progression. High YKL-40 expression is reported during early human development, but its functions are unknown. Six human embryonic stem cell (hESC) lines were cultured in an atmosphere of low or high...... YKL-40 protein and YKL-40 mRNA expression were measured by enzyme-linked immunosorbent assay (ELISA) and quantitative RT-PCR. Serial-sectioned colonies were stained for YKL-40 protein and for pluripotent hESC (OCT4, NANOG) and germ layer (HNF-3ß, PDX1, CD34, p63, nestin, PAX6) markers. Double...

  1. High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival

    DEFF Research Database (Denmark)

    Roslind, Anne; Johansen, Julia S; Christensen, Ib J

    2008-01-01

    by immunohistochemistry in 50 patients. Pretreatment serum YKL-40 was elevated in 53%. Patients with high serum YKL-40 had shorter survival than patients with normal serum YKL-40 (33 vs. 84 months; p = 0.008). Multivariate Cox analysis including pretreatment serum YKL-40, age, sex, primary tumor site, TNM classification...... and treatment demonstrated that TNM classification (HR = 2.61, p = 0.02) and serum YKL-40 (log-transformed continuous variable: HR = 1.55, p...

  2. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

    Directory of Open Access Journals (Sweden)

    Hsiang-Ling Wang

    2013-11-01

    Full Text Available Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP. However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI score (r = 0.630, p < 0.001, the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years score (r = 0.640, p < 0.001, the Acute Physiology And Chronic Health Evaluation II (APACHE II score (r = 0.539, p < 0.001 and length of hospital stay (r = 0.321, p = 0.011, respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.

  3. SERUM YKL-40 IS ASSOCIATED WITH BONE DISEASE IN MULTIPLE MYELOMA

    DEFF Research Database (Denmark)

    Mylin, Anne Kjærsgaard; Abildgaard, Niels; Johansen, Julia S.

    2007-01-01

     Introduction. The secreted glycoprotein YKL-40 (CHI3L1, HC gp-39) is a potential player in the tumor-host interactions affecting several aspects of multiple myeloma (MM) including bone destruction. Previous studies support a role for YKL-40 in remodelling of the extracellular matrix, in angiogen...... Introduction. The secreted glycoprotein YKL-40 (CHI3L1, HC gp-39) is a potential player in the tumor-host interactions affecting several aspects of multiple myeloma (MM) including bone destruction. Previous studies support a role for YKL-40 in remodelling of the extracellular matrix...... and followed for up to 30 months. Skeletal related events (SRE) were registered and subdivided in vertebral fractures and osteolytic events including non-vertebral fractures. Results. 57% of the patients had a S-YKL-40 elevated above the upper limit in an age specific 90 per cent reference range for healthy...... adults. Patients with elevated S-YKL-40 had a higher total X-ray score (p=0.005) and higher levels of S-CTX-MMP (p=0.003), U-PYD (p=0.004) and U-DPD (p=0.002), while U-NTX-1 and the markers of bone formation did not differ from the levels seen in patients with normal S-YKL-40. During follow-up 21...

  4. The distribution of YKL-40 in osteoarthritic and normal human articular cartilage

    DEFF Research Database (Denmark)

    Volck, B; Ostergaard, K; Johansen, J S

    1999-01-01

    YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL...... in chondrocytes of osteoarthritic cartilage mainly in the superficial and middle zone of the cartilage rather than the deep zone. There was a tendency for high number of YKL-40 positive chondrocytes in areas of the femoral head with a considerable biomechanical load. The number of chondrocytes with a positive...

  5. Comparison of serum YKL-40 bio marker levels in primary prostate cancer and recurrent cases after radiotherapy

    International Nuclear Information System (INIS)

    Ziada, M.M.S.

    2012-01-01

    YKL-40, also called human cartilage glycoprotein-39 is homologs of family 18 glycosyl hydrolases secreted by human macrophages.Although high levels of YKL-40 is associated with several diseases. YKL-40, a growth factor for connective tissue cells, a migration factor for endothelial and vascular smooth muscle cells, is expressed by several types of solid human carcinoma, including prostate carcinoma. The aim of this study was to evaluate diagnostic role of serum YKL-40 levels in primary prostate cancer and detection of recurrences after radiotherapy. Methods: YKL-40 determined in serum samples from 50 patients with primary prostate cancer and 25 patients with benign prostatic hyperplasia as control. Serum YKL-40 levels were measured by ELISA. PSA levels were also measured by using IMMULIT system. Results: Serum YKL-40 levels were significantly higher (P= 0.000) in patients with prostate cancer compared with control group whereas no significant elevation in BPH. Conclusion: High serum YKL-40 levels in patients with primary prostate cancer indicate that YKL-40 may have a function in the Progression of malignant diseases, whereas no significant elevation was observed in benign prostatic hyperplasia. Further studies are needed to elucidate the biologic role of YKL-40 in cancer aggressiveness and in progression of malignant diseases.

  6. Expression of the chitinase family glycoprotein YKL-40 in undifferentiated, differentiated and trans-differentiated mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Daniel J Hoover

    Full Text Available The glycoprotein YKL-40 (CHI3L1 is a secreted chitinase family protein that induces angiogenesis, cell survival, and cell proliferation, and plays roles in tissue remodeling and immune regulation. It is expressed primarily in cells of mesenchymal origin, is overexpressed in numerous aggressive carcinomas and sarcomas, but is rarely expressed in normal ectodermal tissues. Bone marrow-derived mesenchymal stem cells (MSCs can be induced to differentiate into various mesenchymal tissues and trans-differentiate into some non-mesenchymal cell types. Since YKL-40 has been used as a mesenchymal marker, we followed YKL-40 expression as undifferentiated MSCs were induced to differentiate into bone, cartilage, and neural phenotypes. Undifferentiated MSCs contain significant levels of YKL-40 mRNA but do not synthesize detectable levels of YKL-40 protein. MSCs induced to differentiate into chondrocytes and osteocytes soon began to express and secrete YKL-40 protein, as do ex vivo cultured chondrocytes and primary osteocytes. In contrast, MSCs induced to trans-differentiate into neurons did not synthesize YKL-40 protein, consistent with the general absence of YKL-40 protein in normal CNS parenchyma. However, these trans-differentiated neurons retained significant levels of YKL-40 mRNA, suggesting the mechanisms which prevented YKL-40 translation in undifferentiated MSCs remained in place, and that these trans-differentiated neurons differ in at least this way from neurons derived from neuronal stem cells. Utilization of a differentiation protocol containing β-mercaptoethanol resulted in cells that expressed significant amounts of intracellular YKL-40 protein that was not secreted, which is not seen in normal cells. Thus the synthesis of YKL-40 protein is a marker for MSC differentiation into mature mesenchymal phenotypes, and the presence of untranslated YKL-40 mRNA in non-mesenchymal cells derived from MSCs reflects differences between differentiated and

  7. YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers.

    Science.gov (United States)

    Brøchner, Christian B; Johansen, Julia S; Larsen, Lars A; Bak, Mads; Mikkelsen, Hanne B; Byskov, Anne Grete; Andersen, Claus Yding; Møllgård, Kjeld

    2012-03-01

    The secreted glycoprotein YKL-40 participates in cell differentiation, inflammation, and cancer progression. High YKL-40 expression is reported during early human development, but its functions are unknown. Six human embryonic stem cell (hESC) lines were cultured in an atmosphere of low or high oxygen tension, in culture medium with or without basic fibroblast growth factor, and on feeder layers comprising mouse embryonic fibroblasts or human foreskin fibroblasts to evaluate whether hESCs and their progeny produced YKL-40 and to characterize YKL-40 expression during differentiation. Secreted YKL-40 protein and YKL-40 mRNA expression were measured by enzyme-linked immunosorbent assay (ELISA) and quantitative RT-PCR. Serial-sectioned colonies were stained for YKL-40 protein and for pluripotent hESC (OCT4, NANOG) and germ layer (HNF-3β, PDX1, CD34, p63, nestin, PAX6) markers. Double-labeling showed YKL-40 expression in OCT4-positive hESCs, PAX6-positive neuroectodermal cells, and HNF-3β-positive endodermal cells. The differentiating progeny showed strong YKL-40 expression. Abrupt transition between YKL-40 and OCT4-positive hESCs and YKL-40-positive ecto- and neuroectodermal lineages was observed within the same epithelial-like layer. YKL-40-positive cells within deeper layers lacked contact with OCT4-positive cells. YKL-40 may be important in initial cell differentiation from hESCs toward ectoderm and neuroectoderm, with retained epithelial morphology, whereas later differentiation into endoderm and mesoderm involves a transition into the deeper layers of the colony.

  8. YKL-40 in patients with end-stage renal disease receiving haemodialysis

    DEFF Research Database (Denmark)

    Nielsen, Ture Lange; Plesner, Louis Lind; Warming, Peder Emil

    2018-01-01

    PURPOSE: This study aimed to determine serum YKL-40 in patients with end-stage renal disease (ESRD) on haemodialysis (HD) and to evaluate the prognostic value of serum YKL-40. METHODS: Patients >18 years on maintenance HD were included. Serum YKL-40 was measured using ELISA before and after...... a single HD treatment. RESULTS: A total of 306 patients were included. Median serum YKL-40 concentration was 238 µgL-1(IQR: 193-291 µgL-1) before HD treatment and 198 µgL-1(IQR: 147-258 µgL-1) after HD treatment, which corresponded to age-corrected 93th percentile in healthy subjects. All-cause mortality...

  9. Serum YKL-40 as a potential biomarker of inflammation in psoriasis.

    Science.gov (United States)

    Baran, Anna; Myśliwiec, Hanna; Szterling-Jaworowska, Malgorzata; Kiluk, Paulina; Świderska, Magdalena; Flisiak, Iwona

    2018-02-01

    YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled. Blood samples were collected before and after 2 weeks of therapy. Serum YKL-40 concentrations were evaluated by enzyme-linked immunosorbent assay (ELISA). The results were correlated with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory and biochemical markers, lipid profile and topical therapy. Median YKL-40 serum levels were significantly increased in psoriatic patients in comparison to the controls (p psoriasis and inflammation in psoriatic patients, but not a reliable indicator of metabolic conditions, severity of psoriasis nor efficacy of the treatment.

  10. Resveratrol represses YKL-40 expression in human glioma U87 cells

    International Nuclear Information System (INIS)

    Zhang, Wei; Tamiya, Takashi; Murao, Koji; Zhang, Xiang; Matsumoto, Kensuke; Diah, Suwarni; Okada, Masaki; Miyake, Keisuke; Kawai, Nobuyuki; Fei, Zhou

    2010-01-01

    Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with tumour burden in addition to being an independent prognostic factor of a short relapse-free interval as well as short overall survival in patients with various cancers. Our previous study revealed that YKL-40 was closely correlated with the pathological grades of human primary astrocytomas and played a crucial role in glioma cell proliferation. Hence, YKL-40 could be an attractive target in the design of anti-cancer therapies. Cell viability and invasion assays were performed to detect the cell proliferation and invasive ability of U87 cells induced by resveratrol (3, 5, 4'-trihydroxystilbene; Res) or YKL-40 small-interfering RNAs (siRNAs). In addition, the luciferase assay, real-time RT-PCR, western blotting, and ELISA were used to measure YKL-40 promoter activity, mRNA, and protein expression, respectively. The expressions of phosphor-ERK1/2 and ERK1/2 were determined by western blotting. Res inhibited U87 cell proliferation and invasion in vitro and repressed YKL-40 in U87 cells by decreasing the activity of its promoter and reducing mRNA transcription and protein expression in vitro. YKL-40 siRNA treatment also impaired the invasiveness of U87 cells. When U87 cells were cultured with 20 μM PD98059 (an ERK1/2 inhibitor) alone, with 20 μM PD98059 and 100 μM Res, or with 100 μM Res alone for 48 h, YKL-40 protein expression decreased most significantly in the Res-treated group. PD98059 partially reversed the decrease of YKL-40 protein expression induced by Res. Furthermore, phosphor-ERK1/2 expression was reduced by Res treatment in a time-dependent manner. We demonstrated for the first time that Res

  11. Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cells.

    Science.gov (United States)

    Jeet, Varinder; Tevz, Gregor; Lehman, Melanie; Hollier, Brett; Nelson, Colleen

    2014-10-01

    Chitinase 3-like 1 (CHI3L1 or YKL40) is a secreted glycoprotein highly expressed in tumours from patients with advanced stage cancers, including prostate cancer (PCa). The exact function of YKL40 is poorly understood, but it has been shown to play an important role in promoting tumour angiogenesis and metastasis. The therapeutic value and biological function of YKL40 are unknown in PCa. The objective of this study was to examine the expression and function of YKL40 in PCa. Gene expression analysis demonstrated that YKL40 was highly expressed in metastatic PCa cells when compared with less invasive and normal prostate epithelial cell lines. In addition, the expression was primarily limited to androgen receptor-positive cell lines. Evaluation of YKL40 tissue expression in PCa patients showed a progressive increase in patients with aggressive disease when compared with those with less aggressive cancers and normal controls. Treatment of LNCaP and C4-2B cells with androgens increased YKL40 expression, whereas treatment with an anti-androgen agent decreased the gene expression of YKL40 in androgen-sensitive LNCaP cells. Furthermore, knockdown of YKL40 significantly decreased invasion and migration of PCa cells, whereas overexpression rendered them more invasive and migratory, which was commensurate with an enhancement in the anchorage-independent growth of cells. To our knowledge, this study characterises the role of YKL40 for the first time in PCa. Together, these results suggest that YKL40 plays an important role in PCa progression and thus inhibition of YKL40 may be a potential therapeutic strategy for the treatment of PCa. © 2014 The authors.

  12. Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis—Experience from two prospective cohorts

    DEFF Research Database (Denmark)

    Kornblit, Brian; Hellemann, Dorthe; Munthe-Fog, Lea

    2013-01-01

    YKL-40, derived from the CHI3L1 gene, has been associated with outcome of infectious and inflammatory diseases. We hypothesized that plasma YKL-40 concentrations and CHI3L1 genotype could be used as prognostic biomarkers in the assessment of systemic inflammatory response syndrome (SIRS) and sepsis....... The objective of the study was to assess the prognostic value of plasma YKL-40 and CHI3L1 genotype in patients with SIRS and sepsis. Plasma YKL-40 and CHI3L1 genotype (rs4950928) were analyzed at time of admission to intensive care units (ICU), in two prospective cohorts of consecutive SIRS patients (cohort 1...

  13. A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40

    Directory of Open Access Journals (Sweden)

    Nipaporn Ngernyuang

    2018-02-01

    Full Text Available The heparin-binding glycoprotein YKL-40 (CHI3L1 is intimately associated with microvascularization in multiple human diseases including cancer and inflammation. However, the heparin-binding domain(s pertinent to the angiogenic activity have yet been identified. YKL-40 harbors a consensus heparin-binding motif that consists of positively charged arginine (R and lysine (K (RRDK; residues 144–147; but they don't bind to heparin. Intriguingly, we identified a separate KR-rich domain (residues 334–345 that does display strong heparin binding affinity. A short synthetic peptide spanning this KR-rich domain successfully competed with YKL-40 and blocked its ability to bind heparin. Three individual point mutations, where alanine (A substituted for K or R (K337A, K342A, R344A, led to remarkable decreases in heparin-binding ability and angiogenic activity. In addition, a neutralizing anti-YKL-40 antibody that targets these residues and prevents heparin binding impeded angiogenesis in vitro. MDA-MB-231 breast cancer cells engineered to express ectopic K337A, K342A or R344A mutants displayed reduced tumor development and compromised tumor vessel formation in mice relative to control cells expressing wild-type YKL-40. These data reveal that the KR-rich heparin-binding motif is the functional heparin-binding domain of YKL-40. Our findings shed light on novel molecular mechanisms underlying endothelial cell angiogenesis promoted by YKL-40 in a variety of diseases.

  14. The Association between Genetic Variations of CHI3L1, Levels of the Encoded Glycoprotein YKL-40 and the Lipid Profile in a Danish Population

    DEFF Research Database (Denmark)

    Thomsen, Stine Brinkløv; Rathcke, Camilla Noelle; Skaaby, Tea

    2012-01-01

    The inflammatory biomarker YKL-40 seems to play a role in atherosclerosis and is elevated in patients with obesity, cardiovascular disease and type 2 diabetes. Single nucleotide polymorphisms (SNPs) of the YKL-40 encoding gene, CHI3L1, are associated with inter-individual YKL-40 levels. One study...... of the differentiated lipid profile in a Danish general population....

  15. Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat

    DEFF Research Database (Denmark)

    Andersen, Christen Lykkegaard; Bjørn, Mads Emil; McMullin, Mary Frances

    2014-01-01

    YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy...

  16. YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance

    DEFF Research Database (Denmark)

    Rathcke, C N; Johansen, J S; Vestergaard, H

    2006-01-01

    YKL-40 participates in inflammatory states and vascular processes, which implies that comparison can be made with other inflammatory markers associated with insulin resistance and type 2 diabetes (T2D). In the present study levels of plasma YKL-40 and serum hsCRP were evaluated in patients with T2D....

  17. YKL-40 and Alcoholic Liver and Pancreas Damage and Disease in 86258 Individuals from the General Population

    DEFF Research Database (Denmark)

    Kjaergaard, Alisa D; Bojesen, Stig E; Nordestgaard, Børge G

    2014-01-01

    BACKGROUND: We tested the hypothesis that observationally and genetically increased YKL-40 concentrations are associated with alcoholic liver and pancreas damage and disease. METHODS: We performed cohort and mendelian randomization in 86,258 individuals from the Danish general population......, with measured concentrations of plasma YKL-40 (n = 21 646) and CHI3L1 rs4950928 genotype (n = 84 738). RESULTS: Increased YKL-40 was associated with increased alanine aminotransferase, bilirubin, alkaline phosphatase, γ-glutamyl transferase, erythrocyte mean corpuscular volume, C-reactive protein...... alcoholic liver disease, 4.1 (1.7-10) for alcoholic pancreatitis, and 3.4 (1.9-6.1) for any pancreatitis. CHI3L1 rs4950928 genotype explained 14% of the variation in plasma YKL-40 concentrations but was not associated with alcoholic liver and pancreas damage or disease. A doubling in YKL-40 concentrations...

  18. Elevated plasma YKL-40, lipids and lipoproteins, and ischemic vascular disease in the general population

    DEFF Research Database (Denmark)

    Kjaergaard, Alisa D; Johansen, Julia S; Bojesen, Stig E

    2015-01-01

    BACKGROUND AND PURPOSE: We tested the hypothesis that observationally and genetically elevated YKL-40 is associated with elevated lipids and lipoproteins and with increased risk of ischemic vascular disease. METHODS: We conducted cohort and Mendelian randomization studies in 96 110 individuals from...... the Danish general population, with measured plasma levels of YKL-40 (n=21 647), plasma lipids and lipoproteins (n=94 461), and CHI3L1 rs4950928 genotype (n=94 579). RESULTS: From 1977 to 2013, 3256 individuals developed ischemic stroke, 5629 ischemic cerebrovascular disease, 4183 myocardial infarction...

  19. Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Thomsen, S. B.; Gjesing, A. P.; Rathcke, C. N.

    2015-01-01

    INTRODUCTION: Circulating levels of the inflammatory marker YKL-40 are elevated in cardiovascular disease and obesity-related type 2 diabetes (T2D), and serum YKL-40 levels are related to elements of dyslipidaemia. OBJECTIVE: We aimed to investigate the associations between serum YKL-40 and obesity...... glucose tolerance tests for estimation of glucose tolerance and surrogate measures of insulin sensitivity. Anthropometric measures were retrieved and biochemical measures of the plasma lipid profile and serum YKL-40 levels were obtained. Association-analyses between serum YKL-40 and obesity-related traits...... and estimates of the narrow sense heritability of YKL-40 were based on a polygenic variance component model. RESULTS: Fasting serum levels of YKL-40 were positively associated with waist-hip-ratio (pfasting plasma triglyceride levels (p

  20. High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival

    DEFF Research Database (Denmark)

    Roslind, A.; Johansen, J.S.; Christensen, L.J.

    2008-01-01

    by immunohistochemistry in 50 patients. Pretreatment serum YKL-40 was elevated in 53%. Patients with high serum YKL-40 had shorter survival than patients with normal serum YKL-40 (33 vs. 84 months; p = 0.008). Multivariate Cox analysis including pretreatment serum YKL-40, age, sex, primary tumor site, TNM classification...... and treatment demonstrated that TNM classification (HR = 2.61, p = 0.02) and serum YKL-40 (log-transformed continuous variable: HR = 1.55, p classification (HR = 5.77, p = 0.001) and serum...... YKL-40 (dichotomous variable: HR = 2.75, p = 0.01) were independent predictors of recurrence-free survival. During follow-up after radiotherapy, a high serum YKL-40 (log-transformed continuous variable) in patients with TNM Stage III and TV disease predicted poorer OS within 6 months (HR = 1.95, p

  1. [Changes in serum YKL-40 level and humoral immune function and their significance in children with recurrent pneumonia].

    Science.gov (United States)

    Ma, Wei-Yin; Peng, Shao; Zhang, Ting

    2017-04-01

    To investigate the changes in serum YKL-40 level and humoral immune function and their significance in children with recurrent pneumonia. Blood samples were collected from 30 children with recurrent pneumonia (recurrent pneumonia group), 30 children with acute pneumonia (acute pneumonia group), and 30 healthy children (control group). Serum YKL-40 levels were measured by enzyme-linked immunosorbent assay. The correlation between serum YKL-40 level and laboratory indices related to humoral immune function was analyzed. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum YKL-40 level for recurrent pneumonia. The recurrent pneumonia group had a significantly higher serum YKL-40 level than the acute pneumonia and control groups (Ppneumonia group had a significantly higher serum YKL-40 level than the control group (Ppneumonia group were significantly lower than in the acute pneumonia group (Ppneumonia was 0.958 (95%CI: 0.921-0.994). Humoral immune function is low in children with recurrent pneumonia. Serum YKL-40 may be involved in the occurrence of recurrent pneumonia and can be used as a reference index for diagnosing recurrent pneumonia.

  2. Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

    NARCIS (Netherlands)

    James, Anna J.; Reinius, Lovisa E.; Verhoek, Marri; Gomes, Anna; Kupczyk, Maciej; Hammar, Ulf; Ono, Junya; Ohta, Shoichiro; Izuhara, Kenji; Bel, Elisabeth; Kere, Juha; Söderhäll, Cilla; Dahlén, Barbro; Boot, Rolf G.; Dahlén, Sven-Erik; Gaga, Mina; Siafakas, Nikos M.; Papi, Alberto; Fabbri, Leonardo M.; Joos, Guy; Brusselle, Guy; Rabe, Klaus F.; Kanniess, Frank; Hiemstra, Pieter; Johnston, Sebastian L.; Chanez, Pascal; Vachier, Isabelle; Gjomarkaj, Mark; Sterk, Peter J.; Howarth, Peter H.; Nizankowska-Mogilnicka, Ewa; Middelveld, Roelinde; Holgate, Stephen T.; Wilson, Susan

    2016-01-01

    Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically

  3. Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

    NARCIS (Netherlands)

    James, Anna J.; Reinius, Lovisa E.; Verhoek, Marri; Gomes, Anna; Kupczyk, Maciej; Hammar, Ulf; Ono, Junya; Ohta, Shoichiro; Izuhara, Kenji; Bel, Elisabeth; Kere, Juha; Soderhall, Cilia; Dahlen, Barbro; Boot, Rolf G.; Dahlen, Sven-Erik

    2016-01-01

    Rationale: Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. Objectives: To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and

  4. The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test

    DEFF Research Database (Denmark)

    Dam Mygind, Naja; Axelsson, Anna; Ruwald, Martin Huth

    2016-01-01

    BACKGROUND: Serum YKL-40 is an inflammatory biomarker associated with disease activity and mortality in diseases characterized by inflammation such as coronary artery disease (CAD). Exercise has a positive effect on CAD, possibly mediated by a decreased inflammatory activity. This study aimed...

  5. Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state

    DEFF Research Database (Denmark)

    Bjørn, Mads Emil; Andersen, Christen Lykkegaard; Jensen, Morten Krogh

    2014-01-01

    Chronic myeloproliferative neoplasms (MPN), encompassing essential thrombocythaemia (ET), polycythaemia vera (PV) and myelofibrosis (PMF), are featured by a chronic inflammatory state which is pronounced in myelofibrosis The value of YKL-40 as a biomarker of disease burden has been demonstrated i...

  6. Serum YKL-40 predicts long-term mortality in patients with stable coronary disease

    DEFF Research Database (Denmark)

    Harutyunyan, Marina; Gøtze, Jens P; Winkel, Per

    2013-01-01

    We investigated whether the inflammatory biomarker YKL-40 could improve the long-term prediction of death made by common risk factors plus high-sensitivity C-reactive protein (hs-CRP) and N-terminal-pro-B natriuretic peptide (NT-proBNP) in patients with stable coronary artery disease (CAD)....

  7. The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chunyi; Li, Qi [Division of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, No. 74, Linjiang Road, Yuzhong District, Chongqing 400010 (China); Zhou, Xiangdong, E-mail: zxd999@263.net [Division of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, No. 74, Linjiang Road, Yuzhong District, Chongqing 400010 (China); Kolosov, Victor P.; Perelman, Juliy M. [Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch, Russian Academy of Medical Sciences, Blagoveshchensk (Russian Federation)

    2013-11-01

    Mucus overproduction is an important feature in patients with chronic inflammatory airway diseases. However, the regulatory mechanisms that mediate excessive mucin production remain elusive. Recently, the level of YKL-40, a chitinase-like protein, has been found to be significantly increased in chronic inflammatory airway diseases and has been shown to be associated with the severity of these diseases. In this study, we sought to explore the effect of YKL-40 on mucin5AC (MUC5AC) production in chronic inflammatory airway diseases and the potential signaling pathways involved in this process. We found that elevated YKL-40 levels increased the mRNA and protein expression of MUC5AC in a dose- and time-dependent manner, in association with the phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor κB (NF-κB), reflecting their activation. These responses were significantly suppressed by the knockdown of protease-activating receptor 2 (PAR2) with specific small interfering RNA or the inhibitors of ERK and NF-κB. YKL-40-induced MUC5AC overproduction was also effectively attenuated by the inhibitor of focal adhesion kinase (FAK). Taken together, these results imply that YKL-40 can stimulate excessive MUC5AC production through PAR2- and FAK-mediated mechanisms. - Highlights: • MUC5AC is the major secreted mucin in chronic inflammatory airway diseases. • YKL-40 is a prototype of the chitinase-like protein in mammals. • YKL-40 is an active player in chronic inflammatory airway diseases. • YKL-40 can increase MUC5AC production via PAR2-mediated pathway. • FAK is another candidate to mediate YKL-40-induced MUC5AC overexpression.

  8. The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cells

    International Nuclear Information System (INIS)

    Liu, Chunyi; Li, Qi; Zhou, Xiangdong; Kolosov, Victor P.; Perelman, Juliy M.

    2013-01-01

    Mucus overproduction is an important feature in patients with chronic inflammatory airway diseases. However, the regulatory mechanisms that mediate excessive mucin production remain elusive. Recently, the level of YKL-40, a chitinase-like protein, has been found to be significantly increased in chronic inflammatory airway diseases and has been shown to be associated with the severity of these diseases. In this study, we sought to explore the effect of YKL-40 on mucin5AC (MUC5AC) production in chronic inflammatory airway diseases and the potential signaling pathways involved in this process. We found that elevated YKL-40 levels increased the mRNA and protein expression of MUC5AC in a dose- and time-dependent manner, in association with the phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor κB (NF-κB), reflecting their activation. These responses were significantly suppressed by the knockdown of protease-activating receptor 2 (PAR2) with specific small interfering RNA or the inhibitors of ERK and NF-κB. YKL-40-induced MUC5AC overproduction was also effectively attenuated by the inhibitor of focal adhesion kinase (FAK). Taken together, these results imply that YKL-40 can stimulate excessive MUC5AC production through PAR2- and FAK-mediated mechanisms. - Highlights: • MUC5AC is the major secreted mucin in chronic inflammatory airway diseases. • YKL-40 is a prototype of the chitinase-like protein in mammals. • YKL-40 is an active player in chronic inflammatory airway diseases. • YKL-40 can increase MUC5AC production via PAR2-mediated pathway. • FAK is another candidate to mediate YKL-40-induced MUC5AC overexpression

  9. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis

    DEFF Research Database (Denmark)

    Ostergaard, C; Johansen, JS; Benfield, Thomas

    2002-01-01

    , 663 microg/liter [range, 20 to 8,960]) and encephalitis (5,430 microg/liter [620 to 11,600]) than in patients with lymphocytic meningitis (137 microg/liter [41 to 1,865]) or patients without meningitis (167 microg/liter [24 to 630]) (Kruskal-Wallis and Dunn multiple comparison tests, P ...-Whitney test, P = 0.018). YKL-40 was most likely locally produced, since patients with infections of the central nervous system had CSF YKL-40 levels that were at least 10-fold higher than the corresponding levels in serum (2,033 microg/liter [470 to 11,600] versus 80 microg/liter [19 to 195]). The CSF...

  10. Elevated Plasma YKL-40 Levels and Ischemic Stroke in the General Population

    DEFF Research Database (Denmark)

    Kjaergaard, A.D.; Bojesen, S.E.; Johansen, J.S.

    2010-01-01

    inside the vessel wall. Methods: We measured plasma YKL-40 in 8,899 21- to 93-year-old participants of the Copenhagen City Heart Study 1991-1994 examination, and followed them for up to 18 years. Endpoints were ischemic stroke, ischemic cerebrovascular disease, myocardial infarction, and ischemic heart......% confidence interval, 11%-30%) for ischemic stroke, 16% (8%-24%) for ischemic cerebrovascular disease, 3% (-5%-11%) for myocardial infarction, and 7% (1%-12%) for ischemic heart disease. Interpretation: In the general population, elevated plasma YKL-40 levels are associated with increased risk of ischemic...... stroke and ischemic cerebrovascular disease, independent of plasma CRP levels. ANN NEUROL 2010;68:672-680...

  11. Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Sørensen, Allan Klitgaard; Holmgaard, Dennis Back; Mygind, Lone Hagens

    2015-01-01

    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and progressive decline in pulmonary function. Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers of inflammation and predict mortality in patients with different inflammatory...... diseases. We aimed to investigate the correlation between levels of these three biomarkers and neutrophil granulocyte and lymphocyte count in patients with moderate to very severe COPD stratified by use of systemic glucocorticoids. Furthermore, we studied the ability of these biomarkers to predict all......- and multivariate Cox regression analyses with hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: Plasma calprotectin was positively correlated with neutrophil granulocyte count and NLR. No significant association was found between plasma YKL-40 and the cellular biomarkers, irrespective...

  12. Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells

    Directory of Open Access Journals (Sweden)

    Tibullo eDaniele

    2015-10-01

    Full Text Available Osteolytic bone disease is a common manifestation of multiple myeloma (MM that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients.It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases CHIT1 and YKL40 is associated with osteoclast (OCs differentiation and bone digestion. In the current study, we investigated the effect of two Bortezomib’s concentration (BO (2.5 nM and 5nM on osteoclastogenesis by analyzing regulation of chitinase expression. OCs exposition to BO was able to inhibit the expression of different OCs markers such as RANK, CTSK, TRAP and MMP9. In addition BO-treatment reduced CHIT1 enzymatic activity and both CHIT1 and YKL40 mRNA expression levels and cytoplasmatic and secreted protein. Moreover, immunofluorescence evaluation of mature OCs showed that BO was able to translocate YKL40 into the nucleus, while CHIT1 remained into the cytoplasm. Since MM cell lines such as U266, SKM-M1 and MM1 showed high levels of CHIT1 activity, we analyzed bone resorption ability of U266 using dentin disc assay resorption pits. Silencing chitinase proteins in U266 cell line with specific siRNAs, resulted in pits number reduction on dentine discs. In conclusion, we showed that BO decreases osteoclastogenesis and reduces bone resorption in OCs and U266 cell line by modulating the chitinases CHIT1 and YKL40. These results indicate that chitinases may be a therapeutic target for bone disease in MM patients.

  13. Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells.

    Science.gov (United States)

    Tibullo, Daniele; Di Rosa, Michelino; Giallongo, Cesarina; La Cava, Piera; Parrinello, Nunziatina L; Romano, Alessandra; Conticello, Concetta; Brundo, Maria V; Saccone, Salvatore; Malaguarnera, Lucia; Di Raimondo, Francesco

    2015-01-01

    Osteolytic bone disease is a common manifestation of multiple myeloma (MM) that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients. It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases chitotriosidase (CHIT1) and YKL40 is associated with osteoclast (OCs) differentiation and bone digestion. In the current study, we investigated the effect of two Bortezomib's concentration (2.5 and 5 nM) on osteoclastogenesis by analyzing regulation of chitinase expression. OCs exposition to bortezomib (BO) was able to inhibit the expression of different OCs markers such as RANK, CTSK, TRAP, and MMP9. In addition BO-treatment reduced CHIT1 enzymatic activity and both CHIT1 and YKL40 mRNA expression levels and cytoplasmatic and secreted protein. Moreover, immunofluorescence evaluation of mature OCs showed that BO was able to translocate YKL40 into the nucleus, while CHIT1 remained into the cytoplasm. Since MM cell lines such as U266, SKM-M1 and MM1 showed high levels of CHIT1 activity, we analyzed bone resorption ability of U266 using dentin disk assay resorption pits. Silencing chitinase proteins in U266 cell line with specific small interfering RNA, resulted in pits number reduction on dentine disks. In conclusion, we showed that BO decreases osteoclastogenesis and reduces bone resorption in OCs and U266 cell line by modulating the chitinases CHIT1 and YKL40. These results indicate that chitinases may be a therapeutic target for bone disease in MM patients.

  14. Serum YKL-40 and assessment of severity of bronchial asthma in ...

    African Journals Online (AJOL)

    EL-HAKIM

    YKL-40 and asthma severity. 95. Table 1. Characteristics of the studied groups. Variable. Control. (n=15). Mild-Moderate asthma. (n=15). Severe asthma. (n=15). Age (yrs) mean±SD. 7.7±4.7. 6.6±4.9. 3.3±2.7. Gender (male); n (%). 10 (67%). 9 (60%). 8 (50%). PAS score. 0-4 (normal). 5-7 (mild attack). 8-11(moderate).

  15. Plasma YKL-40 in Patients with Metastatic Colorectal Cancer Treated with First Line Oxaliplatin-Based Regimen with or without Cetuximab

    DEFF Research Database (Denmark)

    Tarpgaard, Line S; Guren, Tormod K; Glimelius, Bengt

    2014-01-01

    AND METHODS: A total of 566 patients in the NORDIC VII Study were randomized 1∶1∶1 to arm A (Nordic FLOX), arm B (Nordic FLOX + cetuximab), or arm C (Nordic FLOX + cetuximab for 16 weeks followed by cetuximab alone as maintenance therapy). Pretreatment plasma samples were available from 510 patients. Plasma...... YKL-40 was determined by ELISA and dichotomized according to the age-corrected 95% YKL-40 level in 3130 healthy subjects. RESULTS: Pretreatment plasma YKL-40 was elevated in 204 patients (40%), and median YKL-40 was higher in patients with mCRC than in healthy subjects (age adjusted, P

  16. Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke

    DEFF Research Database (Denmark)

    Rathcke, Camilla Noelle; Thomsen, Stine Brinkloev; Linneberg, Allan

    2012-01-01

    BACKGROUND: Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease. We investigated the association between single nucleotide polymorphisms (SNPs) of CHI3L1, serum YKL-40...... levels and all-cause and cardiovascular mortality and first-time incidence of myocardial infarction, ischemic heart disease (IHD) and stroke. METHODOLOGY/PRINCIPAL FINDINGS: 12 SNPs of CHI3L1 were genotyped and serum YKL-40 was measured in 2656 Danes representative of the general population. Median...

  17. The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

    DEFF Research Database (Denmark)

    Mygind, Naja Dam; Harutyunyan, Marina J; Mathiasen, Anders Bruun

    2011-01-01

    OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40......, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p ...

  18. Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma

    DEFF Research Database (Denmark)

    Schmidt, Henrik; Johansen, Julia Sidenius; Gehl, Julie

    2006-01-01

    subjects. RESULTS:       Patients had higher serum YKL-40 values than healthy subjects (P poor performance status (P       = 0.002). Multivariate Cox analysis showed......BACKGROUND: YKL-40 is a growth factor for connective tissue cells and       stimulates migration of endothelial cells. Cancer cells, macrophages, and       neutrophils secrete YKL-40. Its function in cancer is unknown. High serum       YKL-40 levels have been associated with a poor prognosis...... was an independent prognostic factor for poor       survival in patients with metastatic melanoma. When combining serum YKL-40       and LDH, patients could be separated into three prognostic groups based on       the number of elevated biomarkers. The findings should be validated in an       independent study...

  19. Serum YKL-40 and uterine artery Doppler – a prospective cohort study, with focus on preeclampsia and small-for-gestational-age

    DEFF Research Database (Denmark)

    Gybel-Brask, Dorte; Høgdall, Estrid; Johansen, Julia

    2014-01-01

    OBJECTIVE: To test if serum YKL-40 is increased in women developing preeclampsia or small-for-gestational age fetuses. We also assessed the association between uterine artery pulsatility index, notching and serum YKL-40 levels. DESIGN: Prospective cohort study. SETTING: A primary referral unit......-week fetal growth examinations. Uterine artery Doppler was assessed and outcome was registered from medical records. MAIN OUTCOME MEASURES: Preeclampsia, hypertension, small-for-gestational age. RESULTS: Serum YKL-40 was associated with increasing maternal age (p ....0002), primiparity (p = 0.0003), and hypertension (p = 0.015). Serum YKL-40 increased from 12 to 20 weeks and decreased from 20-25 and 25-32 weeks of gestation. No association was found between preeclampsia and serum YKL-40. Small-for-gestational-age at birth was significantly associated with a 5.4% increase...

  20. The effect of mud pack therapy on serum YKL-40 and hsCRP levels in patients with knee osteoarthritis.

    Science.gov (United States)

    Güngen, Gonca; Ardic, Fusun; Fındıkoğlu, Gülin; Rota, Simin

    2012-05-01

    The aim of this study was to evaluate the efficacy of treatment with mud pack in knee osteoarthritis (OA) and to determine whether mud pack effects serum levels of YKL-40 and high-sensitivity C-reactive protein (hsCRP) which are reported to be biological markers for articular damage or inflammation in patients with OA. Forty-four patients with the diagnosis of knee OA assigned into two groups were treated with local natural mineral-rich mud pack or hot pack. Treatments were applied for 6 days a week for 2 weeks as a total of 12 sessions. Patients were assessed at baseline, post-treatment, and 3 months after the treatment. VAS, range of motion, 15-m walking time, WOMAC index, Nottingham Health Profile, serum YKL-40, and hsCRP levels were the outcome measures. Pain intensity and joint stiffness decreased in both groups at all follow-ups. Physical activity status was found to persist for 3 months after treatment only in mud pack group. Serum mean YKL-40 and hsCRP levels of the patients were higher compared to healthy control group. Serum YKL-40 level increased significantly only in hot pack group 3 months after the treatment (P 0.05). Mud pack and hot pack therapy were both demonstrated to be effective in symptomatic treatment of knee OA until the end of the 2-week treatment period, whereas only mud pack therapy was shown to be effective in functional status over time. In the hot pack group, increased serum YKL-40 level 3 months after the treatment might indicate persistence of cartilage degradation. Maintenance of YKL-40 level in mud pack therapy seems to slow down the progression of knee OA.

  1. Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects

    Directory of Open Access Journals (Sweden)

    Tuija Väänänen

    2017-01-01

    Full Text Available YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis. Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen production and fibrosis. We studied if YKL-40 is related to inflammation, fibrosis, and/or lung function in subjects exposed to asbestosis. Venous blood samples were collected from 85 men with moderate or heavy occupational asbestos exposure and from 28 healthy, age-matched controls. Levels of plasma YKL-40, CRP, IL-6, adipsin, and MMP-9 were measured with enzyme-linked immunosorbent assay (ELISA. Plasma YKL-40 levels were significantly higher in subjects with asbestosis (n=19 than in those with no fibrotic findings in HRCT following asbestos exposure (n=66 or in unexposed healthy controls. In asbestos-exposed subjects, plasma YKL-40 correlated negatively with lung function capacity parameters FVC (Pearson’s r −0.259, p=0.018 and FEV1 (Pearson’s r −0.240, p=0.028 and positively with CRP (Spearman’s rho 0.371, p<0.001, IL-6 (Spearman’s rho 0.314, p=0.003, adipsin (Spearman’s rho 0.459, p<0.001, and MMP-9 (Spearman’s rho 0.243, p=0.025. The present finding suggests YKL-40 as a biomarker associated with fibrosis and inflammation in asbestos-exposed subjects.

  2. The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review

    Directory of Open Access Journals (Sweden)

    Tong X

    2018-01-01

    Full Text Available Xiang Tong,1 Dongguang Wang,1 Sitong Liu,1 Yao Ma,1,2 Zhenzhen Li,3 Panwen Tian,1,4 Hong Fan1 1Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China; 2The Center of Gerontology and Geriatrics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China; 3Health Management Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China; 4Lung Cancer Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China Background: Many studies have found that YKL-40 may play an important pathogenic role in COPD. However, the results of these studies were inconsistent. Therefore, we performed a systematic review and meta-analysis to investigate the role of YKL-40 in COPD. Methods: We performed a systematic literature search in many database and commercial internet search engines to identify studies involving the role of YKL-40 in patients with COPD. The standardized mean difference (SMD and Fisher’s Z-value with its 95% confidence interval (CI were used to investigate the effect sizes. Results: A total of 15 eligible articles including 16 case–control/cohort groups were included in the meta-analysis. The results indicated that the serum YKL-40 levels in patients with COPD were significantly higher than those in healthy controls (SMD =1.58, 95% CI =0.68–2.49, P=0.001, and it was correlated with lung function (pooled r=-0.32; Z=-0.33; P<0.001. The results of subgroup analysis found that the serum YKL-40 levels were statistically different between the exacerbation group and the stable group in patients with COPD (SMD =1.55, 95% CI =0.81–2.30, P<0.001. Moreover, the results indicated that the sputum YKL-40 levels in patients with COPD were also significantly higher than those in healthy

  3. Automated analysis of calcium spiking profiles with CaSA software: two case studies from root-microbe symbioses.

    Science.gov (United States)

    Russo, Giulia; Spinella, Salvatore; Sciacca, Eva; Bonfante, Paola; Genre, Andrea

    2013-12-26

    Repeated oscillations in intracellular calcium (Ca2+) concentration, known as Ca2+ spiking signals, have been described in plants for a limited number of cellular responses to biotic or abiotic stimuli and most notably the common symbiotic signaling pathway (CSSP) which mediates the recognition by their plant hosts of two endosymbiotic microbes, arbuscular mycorrhizal (AM) fungi and nitrogen fixing rhizobia. The detailed analysis of the complexity and variability of the Ca2+ spiking patterns which have been revealed in recent studies requires both extensive datasets and sophisticated statistical tools. As a contribution, we have developed automated Ca2+ spiking analysis (CaSA) software that performs i) automated peak detection, ii) statistical analyses based on the detected peaks, iii) autocorrelation analysis of peak-to-peak intervals to highlight major traits in the spiking pattern.We have evaluated CaSA in two experimental studies. In the first, CaSA highlighted unpredicted differences in the spiking patterns induced in Medicago truncatula root epidermal cells by exudates of the AM fungus Gigaspora margarita as a function of the phosphate concentration in the growth medium of both host and fungus. In the second study we compared the spiking patterns triggered by either AM fungal or rhizobial symbiotic signals. CaSA revealed the existence of different patterns in signal periodicity, which are thought to contribute to the so-called Ca2+ signature. We therefore propose CaSA as a useful tool for characterizing oscillatory biological phenomena such as Ca2+ spiking.

  4. Observational and genetic plasma YKL-40 and cancer in 96,099 individuals from the general population

    DEFF Research Database (Denmark)

    Kjaergaard, Alisa D; Nordestgaard, Børge G; Johansen, Julia S

    2015-01-01

    . For this purpose, we performed cohort and Mendelian randomization studies in 96,099 individuals from the Danish general population. Plasma levels of YKL-40 were measured in 21,643 and CHI3L1 rs4950928 was genotyped in 94,568 individuals. From 1943 through 2011, 2,291 individuals developed gastrointestinal cancer...

  5. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma

    DEFF Research Database (Denmark)

    Brasso, Klaus; Christensen, Ib Jarle; Johansen, Julia S.

    2006-01-01

    %, BAP (55%), CTX-I (33%), and YKL-40 (43%). Univariate analysis showed an association to survival: PINP (HR = 1.6, P 4, P 4, P = 0.004). In multivariate Cox analysis performance status, WHO grade, Soloway score, PINP...

  6. YKL-40

    DEFF Research Database (Denmark)

    Mathiasen, Anders Bruun; Henningsen, Kristoffer Mads Aaris; Harutyunyan, Marina Jurjevna

    2010-01-01

    . But in spite of improved treatments, many patients are still plagued by a high frequency of angina symptoms, hospitalizations and a poor prognosis. There is a need for new independent or supplementary biomarkers that can help to predict cardiovascular disease and cardiovascular events earlier and more...

  7. PrognosticValue of PINP,BoneAlkaline Phosphatase, CTX-I, andYKL-40 in Patients With Metastatic Prostate Carcinoma

    DEFF Research Database (Denmark)

    Brasso, Klaus; Christensen, Ib Jarle; Johansen, Julia S

    2006-01-01

    Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate. 2006 Apr 1;66(5):503-13. PMID: 16372331 [PubMed - indexed for MEDLINE]......Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate. 2006 Apr 1;66(5):503-13. PMID: 16372331 [PubMed - indexed for MEDLINE]...

  8. YKL-40/c-Met expression in rectal cancer biopsies predicts tumor regression following neoadjuvant chemoradiotherapy: a multi-institutional study.

    Science.gov (United States)

    Senetta, Rebecca; Duregon, Eleonora; Sonetto, Cristina; Spadi, Rossella; Mistrangelo, Massimiliano; Racca, Patrizia; Chiusa, Luigi; Munoz, Fernando H; Ricardi, Umberto; Arezzo, Alberto; Cassenti, Adele; Castellano, Isabella; Papotti, Mauro; Morino, Mario; Risio, Mauro; Cassoni, Paola

    2015-01-01

    Neoadjuvant chemo-radiotherapy (CRT) followed by surgical resection is the standard treatment for locally advanced rectal cancer, although complete tumor pathological regression is achieved in only up to 30% of cases. A clinicopathological and molecular predictive stratification of patients with advanced rectal cancer is still lacking. Here, c-Met and YKL-40 have been studied as putative predictors of CRT response in rectal cancer, due to their reported involvement in chemoradioresistance in various solid tumors. A multicentric study was designed to assess the role of c-Met and YKL-40 expression in predicting chemoradioresistance and to correlate clinical and pathological features with CRT response. Immunohistochemistry and fluorescent in situ hybridization for c-Met were performed on 81 rectal cancer biopsies from patients with locally advanced rectal adenocarcinoma. All patients underwent standard (50.4 gy in 28 fractions + concurrent capecitabine 825 mg/m2) neoadjuvant CRT or the XELOXART protocol. CRT response was documented on surgical resection specimens and recorded as tumor regression grade (TRG) according to the Mandard criteria. A significant correlation between c-Met and YKL-40 expression was observed (R = 0.43). The expressions of c-Met and YKL-40 were both significantly associated with a lack of complete response (86% and 87% of c-Met and YKL-40 positive cases, prectal cancer. Targeted therapy protocols could take advantage of prior evaluations of c-MET and YKL-40 expression levels to increase therapeutic efficacy.

  9. The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure

    DEFF Research Database (Denmark)

    Harutyunyan, Marina; Christiansen, Michael; Johansen, Julia S

    2011-01-01

    peptide (NT-proBNP) could be a new prognostic biomarker for all-cause mortality in patients with HF. METHODS AND RESULTS: A total of 717 of the 1000 patients with severe left ventricular systolic dysfunction included in the EchoCardiography and Heart Outcome Study were included in Denmark and had blood...... YKL-40 II to IV quartiles, respectively following multivariable adjustment for cardiovascular risk factors (age, left ventricular ejection fraction, gender, history of heart failure, ischemic heart disease, chronic pulmonary disease, diabetes mellitus, stroke, hypertension, NT-proBNP, hs......-CRP, and renal function). CONCLUSION: Serum YKL-40 is significantly associated with all-cause mortality in patients with HF and could potentially be a new prognostic biomarker in these patients....

  10. Plasma YKL-40 in patients with metastatic colorectal cancer treated with first line oxaliplatin-based regimen with or without cetuximab: RESULTS from the NORDIC VII Study.

    Directory of Open Access Journals (Sweden)

    Line S Tarpgaard

    Full Text Available We aim to test the hypothesis that high plasma YKL-40 is associated with short progression-free survival (PFS and overall survival (OS in patients with metastatic colorectal cancer (mCRC treated with first-line oxaliplatin and 5-flourouracil with or without cetuximab.A total of 566 patients in the NORDIC VII Study were randomized 1∶1∶1 to arm A (Nordic FLOX, arm B (Nordic FLOX + cetuximab, or arm C (Nordic FLOX + cetuximab for 16 weeks followed by cetuximab alone as maintenance therapy. Pretreatment plasma samples were available from 510 patients. Plasma YKL-40 was determined by ELISA and dichotomized according to the age-corrected 95% YKL-40 level in 3130 healthy subjects.Pretreatment plasma YKL-40 was elevated in 204 patients (40%, and median YKL-40 was higher in patients with mCRC than in healthy subjects (age adjusted, P<0.001. Patients with elevated YKL-40 had shorter PFS than patients with normal YKL-40 (7.5 vs. 8.2 months; hazard ratio (HR  = 1.27 95% confidence interval (CI 1.05-1.53 P = 0.013 and shorter OS (16.8 vs. 23.9 months; HR = 1.33, 1.04-1.69, P = 0.024. Multivariate Cox analysis demonstrated that elevated pretreatment YKL-40 was an independent biomarker of short OS (HR = 1.12, 1.01-1.25, P = 0.033. The ratio of the updated plasma YKL-40 (i.e. level after 1, 2, 8 weeks of treatment, and at end of treatment compared to the baseline level was associated with OS (HR = 1.27, 1.06-1.52, P = 0.011.Plasma YKL-40 is an independent prognostic biomarker in patients with mCRC treated with first-line oxaliplatin-based therapy alone or combined with cetuximab.

  11. Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Kim Hyun

    2012-07-01

    Full Text Available Abstract Background Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation to final rupture of the plaque. In this study, we investigated the potential pathophysiological and clinical relevance of novel cytokines secreted from various cells including adipocytes, endothelial cells, and inflammatory cells, in predicting coronary artery disease (CAD in asymptomatic subjects with type 2 diabetes mellitus. Methods We enrolled a total of 70 asymptomatic type 2 diabetic patients without a documented history of cardiovascular disease, and determined serum levels of chemerin, omentin-1, YKL-40, and sCD26. We performed coronary computed tomographic angiography (cCTA in all subjects, and defined coronary artery stenosis ≥ 50 % as significant CAD in this study. Results Subjects were classified into two groups: patients with suspected coronary artery stenosis on cCTA (group I, n = 41 and patients without any evidence of stenosis on cCTA (group II, n = 29. Group I showed significantly higher YLK-40 levels and lower HDL-C levels than group II (p = 0.038, 0.036, respectively. Levels of chemerin, omentin-1, and sCD26 were not significantly different between the two groups. Serum YKL-40 levels were positively correlated with systolic/diastolic BP, fasting/postprandial triglyceride levels, and Framingham risk score. Furthermore, YKL-40 levels showed moderate correlation with the degree of coronary artery stenosis and the coronary artery calcium score determined from cCTA. In multivariate logistic analysis, after adjusting for age, gender, smoking history, hypertension, and LDL-cholesterol, YLK-40 levels showed only borderline significance. Conclusions YKL-40, which is secreted primarily from inflammatory cells, was associated with several CVD risk factors and was elevated in type 2 diabetic patients with suspected coronary artery stensosis on cCTA. These results suggest

  12. Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population

    DEFF Research Database (Denmark)

    Johansen, J.S.; Bojesen, S.E.; Mylin, A.K.

    2009-01-01

    ,899 subjects (20 to 95 years) from the Danish general population, the Copenhagen City Heart Study, observed for 11 years for cancer incidence and 14 years for death: 1,432 participants had a first incident cancer, 968 of these died. Hazard ratios (HRs) for cancer events and death after events according...... to plasma YKL-40 in sex and 10 years age percentile categories: 0% to 33%, 34% to 66%, 67% to 90%, 91% to 95%, and 96% to 100%. RESULTS: The cumulative incidence of gastrointestinal cancer increased with increasing YKL-40 (trend P ....0 (95% CI, 0.7 to 1.5) for YKL-40 in category 34% to 66%, 1.5 for 67% to 90% (95% CI, 1.0 to 2.3), 2.4 for 91% to 95%, (95% CI, 1.3 to 4.6), and 3.4 for 96% to 100% (95% CI, 1.9 to 6.1) versus YKL-40 category 0% to 33% (P any cancer event and YKL-40 category 91% to 100% had...

  13. YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Te-Mao Li

    2017-04-01

    Full Text Available YKL-40, also known as human cartilage glycoprotein-39 or chitinase-3-like-1, is a pro-inflammatory protein that is highly expressed in rheumatoid arthritis (RA patients. Angiogenesis is a critical step in the pathogenesis of RA, promoting the infiltration of inflammatory cells into joints and providing oxygen and nutrients to RA pannus. In this study, we examined the effects of YKL-40 in the production of the pro-inflammatory cytokine interleukin-18 (IL-18, and the stimulation of angiogenesis and accumulation of osteoblasts. We observed that YKL-40 induces IL-18 production in osteoblasts and thereby stimulates angiogenesis of endothelial progenitor cells (EPCs. We found that this process occurs through the suppression of miR-590-3p via the focal adhesion kinase (FAK/PI3K/Akt signaling pathway. YKL-40 inhibition reduced angiogenesis in in vivo models of angiogenesis: the chick embryo chorioallantoic membrane (CAM and Matrigel plug models. We report that YKL-40 stimulates IL-18 expression in osteoblasts and facilitates EPC angiogenesis.

  14. Serum YKL-40 Predicts Relapse-Free and Overall Survival in Patients With American Joint Committee on Cancer Stage I and II Melanoma

    DEFF Research Database (Denmark)

    Schmidt, Henrik; Johansen, Julia S; Sjoegren, Pia

    2006-01-01

    level has been associated with poor prognosis in patients with several cancer types. PATIENTS AND METHODS: Serum samples from 234 patients with stage I (n = 162) and II (n = 72) melanoma were analyzed for YKL-40 by enzyme-linked immunosorbent assay. Serial samples were obtained before definitive primary...... surgery and during follow-up. RESULTS: After a median follow-up period of 66 months (range, 1 to 97 months), 41 relapses (18%) and 39 deaths (17%) were observed. Serum YKL-40 treated as an updated continuous covariate were analyzed together with the covariates sex, age, primary tumor site, ulceration...

  15. In vivo CHI3L1 (YKL-40 expression in astrocytes in acute and chronic neurological diseases

    Directory of Open Access Journals (Sweden)

    Hamilton Ronald L

    2010-06-01

    Full Text Available Abstract Background CHI3L1 (YKL-40 is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes. Methods In the current study CHI3L1 transcription and expression were evaluated in a variety of acute and chronic human neurological diseases. Results ELISA revealed significant elevation of CHI3L1 in the CSF of multiple sclerosis (MS patients as well as mild elevation with aging. In situ hybridization (ISH showed CHI3L1 transcription mostly associated with reactive astrocytes, that was more pronounced in inflammatory conditions like lentiviral encephalitis and MS. Comparison of CHI3L1 expression in different stages of brain infarction showed that YKL40 was abundantly expressed in astrocytes during acute phases and diminished to low levels in chronic infarcts. Conclusions Taken together, these findings demonstrate that CHI3L1 is induced in astrocytes in a variety of neurological diseases but that it is most abundantly associated with astrocytes in regions of inflammatory cells.

  16. Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus.

    Science.gov (United States)

    Brinkmann, Christian; Kuckertz, Anika; Schiffer, Thorsten; Bloch, Wilhelm; Predel, Hans-Georg; Brixius, Klara

    2018-05-21

    The fight against type 2 diabetes mellitus (T2DM) is tremendously challenging. This pilot study investigates whether endurance training (3 times per week for 3 months, moderate intensity) can change the skeletal muscle protein contents of chitinase-3-like protein-1 (YKL40), peroxisome proliferator-activated receptor y coactivator-1 and estrogen-related receptor-induced regulator in muscle-1 (PERM1) and heat-shock protein-70 (HSP70), which have been discussed as novel therapeutically relevant targets. Muscle biopsies were obtained from overweight/obese men with T2DM (n = 7, years = 63 ± 9) at T1 (6 weeks pre-training), T2 (1 week pre-training) and T3 (3 to 4 days post-training). The protein levels of YKL40, PERM1, and HSP70 were determined by immunohistochemistry. YKL40, PERM1, and HSP70 were significantly upregulated following endurance training (T2-T3: +103%, +61%, +89%, p = 0.012, p = 0.010, p = 0.028). There was a fiber type-specific distribution of HSP70 with increased protein contents in type I fibers. A significant change in the fiber type distribution with an increase in type I fibers and a decrease in type II fibers was observed post-training. There were no significant differences for YKL40, PERM1, HSP70, or the fiber type distribution between T1 and T2. The training-induced upregulation of YKL40, PERM1, and HSP70 could help manage the diabetic disease and reduce its complications.

  17. Glycoprotein YKL-40: A potential biomarker of disease activity in rheumatoid arthritis during intensive treatment with csDMARDs and infliximab. Evidence from the randomised controlled NEO-RACo trial.

    Directory of Open Access Journals (Sweden)

    Tuija Väänänen

    Full Text Available YKL-40, a chitinase-like glycoprotein associated with inflammation and tissue remodeling, is produced by joint tissues and recognized as a candidate auto-antigen in rheumatoid arthritis (RA. In the present study, we investigated YKL-40 as a potential biomarker of disease activity in patients with early RA at baseline and during intensive treatment aiming for early remission.Ninety-nine patients with early DMARD-naïve RA participated in the NEO-RACo study. For the first four weeks, the patients were treated with the combination of sulphasalazine, methotrexate, hydroxychloroquine and low dose prednisolone (FIN-RACo DMARD combination, and subsequently randomized to receive placebo or infliximab added on the treatment for further 22 weeks. Disease activity was evaluated using the 28-joint disease activity score and plasma YKL-40 concentrations were measured by immunoassay.At the baseline, plasma YKL-40 concentration was 57 ± 37 (mean ± SD ng/ml. YKL-40 was significantly associated with the disease activity score, interleukin-6 and erythrocyte sedimentation rate both at the baseline and during the 26 weeks' treatment. The csDMARD combination decreased YKL-40 levels already during the first four weeks of treatment, and there was no further reduction when the tumour necrosis factor-α antagonist infliximab was added on the combination treatment.High YKL-40 levels were found to be associated with disease activity in early DMARD-naïve RA and during intensive treat-to-target therapy. The present results suggest YKL-40 as a useful biomarker of disease activity in RA to be used to steer treatment towards remission.

  18. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease

    DEFF Research Database (Denmark)

    Thomsen, Stine B; Rathcke, Camilla N; Zerahn, Bo

    2010-01-01

    . In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were evaluated in patients with T2 D and/or ischemic heart disease (IHD). MATERIALS AND METHODS: The study population consisted of 1) patients with T2D (n = 45); 2) patients with IHD (n = 37); patients with both T2D......OBJECTIVE AND DESIGN: Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arteries, is increased in patients with atherosclerosis...... and IHD (n = 20) and 4) healthy controls (n = 20). Biochemical parameters were measured in venous blood samples. RESULTS: Levels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p T2D and IHD had higher MGP levels (p

  19. Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

    Directory of Open Access Journals (Sweden)

    Stine Brinkløv Thomsen

    2013-01-01

    Full Text Available Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1 are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB in subjects with type 2 diabetes (T2D and normal glucose tolerance (NGT. Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001 whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120. Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001 and 1 yr (P<0.0001 in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009. YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021. Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.

  20. Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland.

    Science.gov (United States)

    Schæbel, L H; Vestergaard, H; Laurberg, P; Rathcke, C N; Andersen, S

    2013-06-01

    Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. To assess the association between biomarkers of inflammation and the intake of traditional Inuit diet in addition to Inuit ethnicity. YKL-40 and hsCRP were measured in serum from 535 Inuit and non-Inuit living in the capital city Nuuk in West Greenland or in the main town or a settlement in rural East Greenland. Dietary habits were assessed by an interview-based food frequency questionnaire. The participation rate was 95%. YKL-40 was higher in Inuit than in non-Inuit (p Inuit with a higher intake of traditional Inuit diet (p Inuit from rural compared to urban areas (p Inuit had higher hsCRP compared to non-Inuit (p = 0.003) and hsCRP increased in parallel with intake of traditional Inuit foods (p Inuit (p = 0.004). YKL-40 and hsCRP increased with higher intakes of traditional Inuit diet after adjusting for ethnicity, gender, age, smoking, alcohol intake and BMI. Biomarkers of inflammation vary in parallel with the intake of traditional Inuit diet. A diet based on marine mammals from the Arctic does not reduce inflammatory activity and it may be speculated that markers of inflammation reflect the disease rather than the cause of the disease. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. Effect of scaling and root planing on gingival crevicular fluid level of YKL-40 acute phase protein in chronic periodontitis patients with or without type 2 diabetes mellitus: A clinico-biochemical study

    Directory of Open Access Journals (Sweden)

    Sini Damodar

    2018-01-01

    Full Text Available Background: The aim of the present study was to evaluate the gingival crevicular fluid (GCF levels of YKL-40 acute phase protein in chronic periodontitis (CP with and without type 2 diabetes and also to assess the effect of periodontal therapy (scaling and root planing [SRP] on this GCF biomarker and the clinical parameters. YKL-40 is derived from tyrosine (Y, lysine (K, and leucine (L with a molecular weight of 40 kDa. Materials and Methods: A total of 105 individuals (30–60 years were grouped as 35 individuals each in three groups (Group I – healthy; Group II – CP with diabetes mellitus [DM]; and Group III – CP. Clinical parameters including plaque index, gingival index, probing pocket depth, and clinical attachment level followed by GCF sample collection from test sites were done at baseline and 6 weeks after SRP (among Group II and Group III patients. GCF YKL-40 level was determined by enzyme-linked immunosorbent assay. Results: The mean GCF YKL-40 level at baseline was significantly lower for Group I (309.81 ± 124.93 pg/ml as compared to Group II (924.88 ± 415.28 pg/ml and Group III (834.08 ± 270.42 pg/ml, respectively (P < 0.001. The level reduced significantly 6 weeks after SRP for Group II (507.6 ± 265.03 pg/ml and Group III (499.54 ± 293.38 pg/ml (P < 0.001. Conclusion: The level of GCF YKL-40 in CP patients with or without DM is higher than healthy individuals and the level reduced 6 weeks post-SRP among Group II and Group III. Hence, YKL-40 can be considered as an important biomarker in the diagnosis of CP.

  2. Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

    DEFF Research Database (Denmark)

    Thomsen, Stine Brinkløv; Rathcke, Camilla Noelle; Jørgensen, Nils Bruun

    2013-01-01

    Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states......, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results....... Fasting state MCP-1 levels decreased after RYGB in both groups (P values...

  3. CASA in invertebrates.

    Science.gov (United States)

    van der Horst, Gerhard; Bennett, Monique; Bishop, John D D

    2018-04-09

    Sperm movement has been described in several phyla of invertebrates. Yet, sperm motility has only been quantified using computer-aided sperm analysis (CASA-Mot) in externally fertilising species (broadcast spawners) of two phyla, molluscs and echinoderms. In the present study we quantified in detail the nature of the sperm tracks, percentage motility groupings and detailed kinematics of rapid-, medium- and slow-swimming spermatozoa in the oyster Crassostrea gigas and four species never previously studied by CASA-Mot, namely the molluscs Choromytilus meridionalis, Donax serra and Haliotis midae and the echinoderm Parechinus angulosus. A feature common to all these species are the helical tracks, the diameter of which seems to be species specific. Using CASA-Mot, the behaviour of spermatozoa was also studied over time and in the presence of egg water and Ca2+ modulators such as caffeine and procaine hydrochloride. For the first time, we show that hyperactivation can be induced in all species in the presence of egg water (sea water that was mixed with mature eggs and then centrifuged) and/or caffeine, and these hyperactivated sperm tracks were characterised using CASA-Mot. We relate the different patterns of sperm motility and behaviour to reproductive strategies such as broadcast spawning and spermcasting, and briefly review studies using CASA-Mot on other invertebrates.

  4. Casas publicadas

    OpenAIRE

    Téllez,Andrés

    2010-01-01

    A partir de el hecho de que las casas son las obras de arquitectura más publicadas, el autor analiza comparativamente las obras de este número a través de su categorización basada en cuatro puntos de vista: geografías o distribuciones interiores, transformaciones de obras existentes, localización rural o urbana y referentes previos.

  5. Casa Morpain

    Directory of Open Access Journals (Sweden)

    Parent, Claude

    1962-03-01

    Full Text Available Una casa fin de semana construida en las cercanías de París, en Fontainebleau. Es un proyecto de acusada personalidad, lo que nos lleva a prestarle una atención especial. Ha sido construida en una parcela con mediano desnivel, bien orientada, de fácil acceso y preciosas vistas sobre el Sena y el bosque que se extiende a lo largo de la orilla opuesta.

  6. Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40

    Science.gov (United States)

    DAUGAARD, SØREN; CHRISTENSEN, LISE H; HØGDALL, ESTRID

    2009-01-01

    Chondroid tumors comprise a heterogenous group of benign to overt malignant neoplasms, which may be difficult to differentiate from one another by histological examination. A group of 43 such tumors was stained with nine relevant antibodies in an attempt to find consistent marker profile(s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. All 25 chondrosarcomas showed a positive staining reaction for D2-40, none for actin and CD117, and a partial reactivity for bcl-2 (36%). Chondroblastomas (5/5) and chondromyxoid fibromas (2/5) were the only tumors with a positive reaction for actin, and all chondroblastomas (n=5) and extraskeletal myxoid chondrosarcomas (n=3) were positive for bcl-2. In contrast to all other tumors, two of three extraskeletal myxoid chondrosarcomas were also positive for CD17 and negative for osteonectin, cox-2, mdm-2 and actin. All five chordomas were negative for D2-40 and positive for mdm-2 and YKL-40. The diagnosis of chondrosarcoma may be aided by its positivity for D2-40 and YKL-40 and its lack of reactivity for actin and CD117. This should be seen in the light of no reaction for D2-40 in chordomas and a corresponding lack of reaction for osteonectin, cox-2, mdm-2 and actin in extraskeletal myxoid chondrosarcomas. A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas. PMID:19594492

  7. Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors

    DEFF Research Database (Denmark)

    Pedersen, Susanne Juhl; Hetland, Merete Lund; Sørensen, Inge Juul

    2010-01-01

    The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated...... with tumor necrosis factor-alpha (TNFα) inhibitors and to compare with levels in healthy subjects. Biomarkers were measured in an observational cohort of 49 SpA patients (ankylosing spondylitis, n=32, and psoriatic arthritis, n=17) initiating TNFα inhibitor therapy (infliximab, n=38; etanercept, n=8...

  8. Sin casa, otra vez: la Cañada Real frente a la exclusión habitacional

    OpenAIRE

    Pastor Hernández, Virginia

    2018-01-01

    Se estima que en la Comunidad de Madrid siguen viviendo más de 9000 personas en núcleos chabolistas. El objetivo del trabajo es visibilizar la situación de exclusión habitacional de los asentamientos auto-producidos, y más concretamente el de la Cañada Real Galiana. Para ello, se ha revisado la bibliografía existente sobre el contexto y el concepto de exclusión habitacional. A partir de este marco teórico se ha elaborado un marco analítico que se ha aplicado al caso de estudio de la Cañad...

  9. Casa Sombrilla

    Directory of Open Access Journals (Sweden)

    Franzen, Ulrich

    1963-05-01

    Full Text Available The building is sited on top of a hill, which commands a magnificent view over the river Connecticut. The house is organised on two floor levels and full use is made of the sloping ground. On the lower floor three bedrooms, a dressing room, bathrooms, washing facilities, wardrobes, stores and the boiler room have been located. The top floor includes the main living zone of the house, namely: living-drawing room, dining room, breakfast room, kitchen and services. The structure is metallic and most ingeniously contrived. The roof consists of nine inverted parasol shapes, interconnected by means of three jointed arches. In the top floor the ceilings are covered with Cyprus wood and the floor surface is oak. The house harmonises well with the surrounding scenery. Both the internal and external aspect of the house is richly impressive, this being enhanced by the great simplicity and originality of its design.Se halla emplazada en la cima de un monte, con magníficas vistas sobre el río Connecticut. Se distribuye en dos plantas, según exige la pendiente del terreno: La baja comprende: tres dormitorios, vestidor, baños, lavadero, guardarropas, almacén y sala de calefacción. La alta aloja la zona representativa de la casa: estar-salón, comedor, comedor de desayunos, cocina y aseo. La estructura es metálica y muy ingeniosa. La cubierta se compone de nueve «sombrillas» invertidas y enlazadas entre sí por medio de tres arcos-bisagras. Los techos son de ciprés y los pisos de roble, en el pabellón superior. El aspecto de la casa es armónico con el paisaje, de gran riqueza exterior e interior, y de gran sencillez y originalidad.

  10. Comparison of plasma pigment epithelium-derived factor (PEDF), retinol binding protein 4 (RBP-4), chitinase-3-like protein 1 (YKL-40) and brain-derived neurotrophic factor (BDNF) for the identification of insulin resistance.

    Science.gov (United States)

    Toloza, F J K; Pérez-Matos, M C; Ricardo-Silgado, M L; Morales-Álvarez, M C; Mantilla-Rivas, J O; Pinzón-Cortés, J A; Pérez-Mayorga, M; Arévalo-García, M L; Tolosa-González, G; Mendivil, C O

    2017-09-01

    To evaluate and compare the association of four potential insulin resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and brain-derived neurotrophic factor [BDNF]) with objective measures of IR. We studied 81 subjects with different metabolic profiles. All participants underwent a 5-point OGTT with calculation of multiple IR indexes. A subgroup of 21 participants additionally underwent a hyperinsulinemic-euglycemic clamp. IR was defined as belonging to the highest quartile of incremental area under the insulin curve (iAUCins), or to the lowest quartile of the insulin sensitivity index (ISI). PEDF was associated with adiposity variables. PEDF and RBP4 increased linearly across quartiles of iAUCins (for PEDF p-trend=0.029; for RBP-4 p-trend=0.053). YKL-40 and BDNF were not associated with any adiposity or IR variable. PEDF and RBP-4 levels identified individuals with IR by the iAUCins definition: A PEDF cutoff of 11.9ng/mL had 60% sensitivity and 68% specificity, while a RBP-4 cutoff of 71.6ng/mL had 70% sensitivity and 57% specificity. In multiple regression analyses simultaneously including clinical variables and the studied biomarkers, only BMI, PEDF and RBP-4 remained significant predictors of IR. Plasma PEDF and RBP4 identified IR in subjects with no prior diagnosis of diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Casa Gold

    Directory of Open Access Journals (Sweden)

    Schürmann, Joachim

    1963-05-01

    entorpezcan la visión de la casa. La piscina es como una continuación de la sala de estar, a través del porche, al que se accede por dos puertas practicadas en el cerramiento de cristal, completamente diáfano, del salón.

  12. Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40

    DEFF Research Database (Denmark)

    Daugaard, Søren; Christensen, Lise H; Høgdall, Estrid

    2009-01-01

    (s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL......-40. All 25 chondrosarcomas showed a positive staining reaction for D2-40, none for actin and CD117, and a partial reactivity for bcl-2 (36%). Chondroblastomas (5/5) and chondromyxoid fibromas (2/5) were the only tumors with a positive reaction for actin, and all chondroblastomas (n=5...... chondrosarcomas. A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas....

  13. The CASA Software Package

    Science.gov (United States)

    Petry, Dirk

    2018-03-01

    CASA is the standard science data analysis package for ALMA and VLA but it can also be used for the analysis of data from other observatories. In this talk, I will give an overview of the structure and features of CASA, who develops it, and the present status and plans, and then show typical analysis workflows for ALMA data with special emphasis on the handling of single dish data and its combination with interferometric data.

  14. CASA Fact Sheet.

    Science.gov (United States)

    National Court Appointed Special Advocate Association, Seattle WA.

    Each year nearly 400,000 children in the United States are thrust into court through no fault of their own. Often these children also become victims of the United States' overburdened child welfare system. A Court Appointed Special Advocate (CASA) volunteer is a trained citizen who is appointed by a judge to represent the best interests of a child…

  15. Status for CASA NOVA konsortiet

    DEFF Research Database (Denmark)

    Bonke, Sten

    1997-01-01

    The report reviews the development projects and the results hitherto achieved by the design and build organisation CASA NOVA which is one of four consortia within the R&D programme "Process and Product Development in Building", financed by the Ministry of Industry and the Ministry of Housing....

  16. Casa - estudio de un escultor

    Directory of Open Access Journals (Sweden)

    Enzo Venturelli

    2017-05-01

    Full Text Available La nueva arquitectura, como las antiguas o simplemente anteriores, está ligada al concepto social de la época, a pesar de lo cual hay siempre una constante que debe mantenerse: el hombre vive dentro de la casa y, por consiguiente, es preciso que se le dé un carácter cálido, vivo, movido..., humano.

  17. CASA-MIA: A ''precision'' EAS detector

    International Nuclear Information System (INIS)

    Borione, A.; Cronin, J.W.; Covault, C.E.; Fick, B.E.; Gibbs, K.G.; Krimm, H.A.; McKay, T.A.; Mueller, D.; Newport, B.J.; Ong, R.A.; Rosenberg, L.J.; Catanese, M.; Green, K.D.; Matthews, J.; Nitz, D.F.; Sinclair, D.; van der Velde, J.C.; Kieda, D.

    1993-01-01

    The CASA-MIA detector was constructed to search for sources of UHE neutral radiation. As such it has established limits well below those of previously reported observations and of most contemporaneous detectors. In addition to its primary mission, however, CASA-MIA measures the lateral distribution of both electrons and muons in EAS throughout a range of energies and with a degree of sampling not previously available

  18. Mi Casa Es Su Casa: Sandra Tauler--City Librarian, Calexico, CA

    Science.gov (United States)

    Library Journal, 2005

    2005-01-01

    Sandra Tauler has tailored her collection and services to the needs of a community that is 97 percent Hispanic. Unfortunately, that's only half the job. The other half is getting potential users through the door. The solution Tauler and other Imperial Valley librarians came up with was Proyecto Televista. With LSTA funding, and the assistance of…

  19. Casa de viviendas en Madrid

    Directory of Open Access Journals (Sweden)

    Lamela Martínez, Antonio

    1963-09-01

    Full Text Available This building occupies a site of 1990 sq. ms, and includes 29 apartments distributed in a semi ground floor, five standard floor levels, an attic and a double attic. The services have been located in a second basement, and the ground floor and first basement are being devoted to commercial uses, such as shops. In order to provide more free space for the commercial zone, the beginning of the stairs and the entry to the lifts is situated on the semi ground floor level. The porter's quarters, refuse reception cubicle and porter's hall have also been placed at this level. The basic nuclei of the apartments are clearly separated into zones daytime living quarters, night quarters and services. It is noteworthy that passages have been largely eliminated, and circulation problems have been otherwise solved, avoiding to some extent the crossing of the main lines of human circulation. The area devoted to social life has been increased as far as possible, and its environment has been enlarged by means of balcony-terraces. The fine aesthetic quality of the building, in its external aspect, is largely due to the clever way in which the materials have been used, exploiting their textures and combining these harmoniously.Ha sido construida sobre un solar de 1.991,41 m2 y consta de 29 viviendas distribuidas en cinco plantas- tipo, ático, doble ático y entreplanta. Los servicios generales de la casa están situados en el segundo sótano; la planta baja y el primer sótano albergan los locales comerciales. Para conseguir una mayor superficie en dichos locales se ha adoptado la solución de situar el arranque de escalera y ascensores en la entreplanta, donde, asimismo, aparecen ubicados los servicios de vigilancia, cuarto de recepción de basuras y vivienda del portero.

  20. CASAS: A Smart Home in a Box.

    Science.gov (United States)

    Cook, Diane J; Crandall, Aaron S; Thomas, Brian L; Krishnan, Narayanan C

    2013-07-01

    While the potential benefits of smart home technology are widely recognized, a lightweight design is needed for the benefits to be realized at a large scale. We introduce the CASAS "smart home in a box", a lightweight smart home design that is easy to install and provides smart home capabilities out of the box with no customization or training. We discuss types of data analysis that have been performed by the CASAS group and can be pursued in the future by using this approach to designing and implementing smart home technologies.

  1. CASAS: A Smart Home in a Box

    OpenAIRE

    Cook, Diane J.; Crandall, Aaron S.; Thomas, Brian L.; Krishnan, Narayanan C.

    2012-01-01

    While the potential benefits of smart home technology are widely recognized, a lightweight design is needed for the benefits to be realized at a large scale. We introduce the CASAS “smart home in a box”, a lightweight smart home design that is easy to install and provides smart home capabilities out of the box with no customization or training. We discuss types of data analysis that have been performed by the CASAS group and can be pursued in the future by using this approach to designing and...

  2. Study of the CASAS Relationship to GED 2002. Research Brief

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2003

    2003-01-01

    CASAS, in cooperation with the CASAS National Consortium Policy Council, conducted a study to provide guidance to program and instructional staff regarding student readiness to take the GED Tests. The study looked at the relationship of CASAS reading and math scores to official 2002 GED test results from five states--California, Hawaii, Iowa,…

  3. The Effectiveness of CASAs in Achieving Positive Outcomes for Children.

    Science.gov (United States)

    Litzelfelner, Pat

    2000-01-01

    Evaluated effectiveness of court-appointed special advocates (CASAs) in achieving positive outcomes for children in the child welfare system, using data from court and CASA program files on 200 children. Found that CASAs may have reduced the number of placements and court continuances children experienced. More services were provided to children…

  4. CASAS: An Effective Measurement System for Life Skills.

    Science.gov (United States)

    Stiles, Richard L.; And Others

    The California Adult Student Assessment System (CASAS) is a comprehensive educational system designed to enable adult educators to develop and evaluate a life skills curriculum for competency based educational programs. The system comprises the CASAS Competency List, the CASAS Item Bank, the User's Manual, the Curriculum Index and Matrix, and…

  5. Casa De La Solidaridad: A Pedagogy of Solidarity

    Science.gov (United States)

    Yonkers-Talz, Kevin

    2013-01-01

    Casa de la Solidaridad has been recognized as an innovative and effective educational model within Jesuit higher education yet, until now, there have only been verbal presentations of the unique attributes of the Casa de la Solidaridad model. In addition, there has been a lack of information regarding the influence of the Casa experience on the…

  6. Evolución de una casa

    Directory of Open Access Journals (Sweden)

    Mac L. Johansen, John

    1958-02-01

    Full Text Available La forma, aspecto, estructura, concepción y realización de una casa están en estrecha relación con el ambiente cultural, social y técnico que la rodean y con ellos evolucionan.

  7. CASA-Mot in mammals: an update.

    Science.gov (United States)

    Yániz, J L; Silvestre, M A; Santolaria, P; Soler, C

    2018-03-08

    Sperm motility is one of the most widely used parameters of sperm quality. Computer-aided sperm motility analysis (CASA-Mot) systems were developed to reduce the subjectivity of sperm motility assessment, and have had broad scientific and practical acceptance. In this review, the sources of variation and current applications of this technology and its relationships with other sperm quality tests are described in detail. Despite remarkable advances in the technique, there is still great need for standardisation in many species, and the numerous factors that affect the results make it difficult to provide universally accepted criteria for classifying semen samples based on sperm motility characteristics. The main fields for CASA-Mot include the study of male fertility and pathologies, evaluation of the effects of physical and chemical agents, improvement of epidemiological survey studies, more precise calculation of seminal doses for farm animals, realisation of basic studies about sperm function, improvement of sperm technologies such as cryopreservation and quality control analysis. Numerous relationships have been established between CASA-Mot and other sperm quality tests, although most of these parameters are complementary. Future CASA-Mot systems will probably be able to integrate several sperm quality parameters with motility.

  8. Plan de viabilidad de una casa rural

    OpenAIRE

    Nieto González, Óscar

    2011-01-01

    Este proyecto consiste en la puesta en marcha de una casa rural en la localidad de Argés, próxima a la ciudad de Toledo, se llamará “La Casona de Argés”, la casa tendrá 4 habitaciones dobles y una suite, todas ellas con cuarto de baño y además de las estancias habituales como cocina y salón dispondrá de un semisótano destinado a zona de juegos, una piscina, y una amplia parcela acondicionada para juegos y disfrute de los huéspedes. El negocio va estar enfocado a un público que viaje con niños...

  9. Gamma-Ray Hold-up Measurements and Results for Casa 2 and Casa 3 at TA-18

    International Nuclear Information System (INIS)

    Desimone, David J.; Vo, Duc Ta

    2016-01-01

    Numerous critical assembly experiments were performed at TA-18 beginning in the 1940's. Several buildings, Casa 2 and Casa 3, were constructed to house these experiments. All gamma-ray hold-up measurements and analysis were performed for Casa 2 and Casa 3 in November/December 2015 to support decommissioning and demolition of the facilities. A technique called room hold-up was used to measure the nuclear materials. A grid pattern was laid out on the large room floor approximately every 9-10 feet. A three- to five-minute measurement was taken with a high-purity germanium (HPGe) detector at each location. Also, several measurements were taken in two storage vaults of Casa 3. A calibration check of the detectors showed that the efficiency and energy scale were stable. The final results of the hold-up measurements for Casa 2 and 3 are given.

  10. CASA: tracking the past and plotting the future.

    Science.gov (United States)

    Gallagher, M T; Smith, D J; Kirkman-Brown, J C

    2018-05-29

    The human semen sample carries a wealth of information of varying degrees of accessibility ranging from the traditional visual measures of count and motility to those that need a more computational approach, such as tracking the flagellar waveform. Although computer-aided sperm analysis (CASA) options are becoming more widespread, the gold standard for clinical semen analysis requires trained laboratory staff. In this review we characterise the key attitudes towards the use of CASA and set out areas in which CASA should, and should not, be used and improved. We provide an overview of the current CASA landscape, discussing clinical uses as well as potential areas for the clinical translation of existing research technologies. Finally, we discuss where we see potential for the future of CASA, and how the integration of mathematical modelling and new technologies, such as automated flagellar tracking, may open new doors in clinical semen analysis.

  11. Critical Pedagogy and Its Application to Health Education: A Critical Appraisal of the Casa en Casa Model.

    Science.gov (United States)

    Merideth, Emily

    1994-01-01

    Casa en Casa, a popular education project of an Oakland, California, community health clinic, has two key weaknesses: volunteers received little orientation to the role of health promoter, and promoters were given content knowledge without development of the skills needed to use it. (SK)

  12. CASA Uno GPS orbit and baseline experiments

    Science.gov (United States)

    Schutz, B. E.; Ho, C. S.; Abusali, P. A. M.; Tapley, B. D.

    1990-01-01

    CASA Uno data from sites distributed in longitude from Australia to Europe have been used to determine orbits of the GPS satellites. The characteristics of the orbits determined from double difference phase have been evaluated through comparisons of two-week solutions with one-week solutions and by comparisons of predicted and estimated orbits. Evidence of unmodeled effects is demonstrated, particularly associated with the orbit planes that experience solar eclipse. The orbit accuracy has been assessed through the repeatability of unconstrained estimated baseline vectors ranging from 245 km to 5400 km. Both the baseline repeatability and the comparison with independent space geodetic methods give results at the level of 1-2 parts in 100,000,000. In addition, the Mojave/Owens Valley (245 km) and Kokee Park/Ft. Davis (5409 km) estimates agree with VLBI and SLR to better than 1 part in 100,000,000.

  13. Casas-Ibarra parametrization and leptogenesis

    International Nuclear Information System (INIS)

    Xing Zhizhong

    2010-01-01

    The Casas-Ibarra parametrization is a description of the Dirac neutrino mass matrix M D in terms of the neutrino mixing matrix V, an orthogonal matrix O and the diagonal mass matrices of light and heavy Majorana neutrinos in the type-I seesaw mechanism. Because M D + M D is apparently independent of V but dependent on O in this parametrization, a number of authors have claimed that unflavored leptogenesis has nothing to do with CP violation at low energies. Here we question this logic by clarifying the physical meaning of O. We establish a clear relationship between O and the observable quantities, and find that O does depend on V. We show that both unflavored leptogenesis and flavored leptogenesis have no direct connection with low-energy CP violation. (authors)

  14. Casa do Alambique, estrutura rara e monumental

    OpenAIRE

    Cardoso, João Luís

    2014-01-01

    Uma intervenção arqueológica realizada em 2009 na Casa do Alambique, localizada na Quinta do Marquês de Pombal, em Oeiras, evidenciou a importância da produção de aguardente a partir da destilação do bagaço ou do vinho naquela quinta setecentista. O seu estudo, através da escavação e do registo, revelou assinaláveis cuidados técnicos, viabilizados por um já desenvolvido conhecimento científico, alicerçado no empirismo, conforme era usual na época. Trata-se de uma rara e monumental estru...

  15. 78 FR 76050 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2013-12-16

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeron[aacute]uticas, S.A... rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain EADS CASA (Type...., Washington, DC. For EADS-CASA service information identified in this AD, contact EADS-CASA, Military...

  16. CASAS: Cancer Survival Analysis Suite, a web based application.

    Science.gov (United States)

    Rupji, Manali; Zhang, Xinyan; Kowalski, Jeanne

    2017-01-01

    We present CASAS, a shiny R based tool for interactive survival analysis and visualization of results. The tool provides a web-based one stop shop to perform the following types of survival analysis:  quantile, landmark and competing risks, in addition to standard survival analysis.  The interface makes it easy to perform such survival analyses and obtain results using the interactive Kaplan-Meier and cumulative incidence plots.  Univariate analysis can be performed on one or several user specified variable(s) simultaneously, the results of which are displayed in a single table that includes log rank p-values and hazard ratios along with their significance. For several quantile survival analyses from multiple cancer types, a single summary grid is constructed. The CASAS package has been implemented in R and is available via http://shinygispa.winship.emory.edu/CASAS/. The developmental repository is available at https://github.com/manalirupji/CASAS/.

  17. Casas de altos en Concepción

    Directory of Open Access Journals (Sweden)

    Rodrigo Fischer Pérez

    1990-06-01

    Full Text Available La casa de altos es una construcción eminentemente urbana. Pareada junto a otras construcciones, va formando bordes continuos, cuyos primeros pisos son generalmente comerciales y los superiores habitacionales.

  18. Casa Grande Ruins National Monument acoustical monitoring 2010

    Science.gov (United States)

    2014-11-01

    During September 2010, The Volpe Center collected baseline acoustical data at Casa Grande National Monument (CAGR), at one site for 28 days. The baseline data collected during this period will help park managers and planners estimate the effects of f...

  19. Current perspectives of CASA applications in diverse mammalian spermatozoa.

    Science.gov (United States)

    van der Horst, Gerhard; Maree, Liana; du Plessis, Stefan S

    2018-03-26

    Since the advent of computer-aided sperm analysis (CASA) some four decades ago, advances in computer technology and software algorithms have helped establish it as a research and diagnostic instrument for the analysis of spermatozoa. Despite mammalian spermatozoa being the most diverse cell type known, CASA is a great tool that has the capacity to provide rapid, reliable and objective quantitative assessment of sperm quality. This paper provides contemporary research findings illustrating the scientific and commercial applications of CASA and its ability to evaluate diverse mammalian spermatozoa (human, primates, rodents, domestic mammals, wildlife species) at both structural and functional levels. The potential of CASA to quantitatively measure essential aspects related to sperm subpopulations, hyperactivation, morphology and morphometry is also demonstrated. Furthermore, applications of CASA are provided for improved mammalian sperm quality assessment, evaluation of sperm functionality and the effect of different chemical substances or pathologies on sperm fertilising ability. It is clear that CASA has evolved significantly and is currently superior to many manual techniques in the research and clinical setting.

  20. House, a feminine noun: representating architectural spaces in Casa e Jardim and Casa Claudia in age the great magazines

    Directory of Open Access Journals (Sweden)

    Rafael Alves Pinto Junior

    2011-12-01

    Full Text Available The emergence of magazines focusing on architecture and aimed at the general public, such as Casa e jardim in the 1950s and Casa Claudia in the 1970s, represented the creation of a culture of living associated with domestic spaces and the values this space represents as a typological object after the second half of the 20th century. Among other things, it affirmed the values of the social roles of women and architecture as the depository of the attributes of privacy and intimacy: the locus of family, memory and affection. The magazines set the tone for representing the architectural space as an area for living, legitimizing behaviors while exercising an aesthetic pedagogy, ushering in a culture associated with living and establishing a source for imagined ways of building in Brazil. By affirming an image of civilization, both Casa e jardim and Casa Claudia became a benchmark for other periodicals devoted to this theme.

  1. La casa Harry Seidler – Australia

    Directory of Open Access Journals (Sweden)

    Seidler, Harry

    1970-12-01

    Full Text Available The steep slope of the site has been utilised by the architects, who are also the owners, to establish various floor levels, corresponding to separate environmental zones, and thus adapt closely the functional aspects of the building to the ground topography. The house has a rectangular planform, and internally there is a sunny part mainly used during daytime, and a more protected one, suitable for relaxation and gentle activity. The interior is restful, and provides excellent visual perspectives in all directions, whilst the decoration, illumination and materials have been most tastefully chosen.El fuerte declive que presentaba la parcela fue aprovechado por los arquitectos —que al mismo tiempo son propietarios— para crear diferentes niveles, y en ellos diversos ambientes, y lograr la máxima adaptación de la edificación a la topografía del terreno. La casa adopta en planta ima forma rectangular, y en su interior se pueden apreciar: una soleada zona en la que desarrollan sus moradores «usos y actividades diurnas», y una sombreada zona destinada a «usos pasivos, tranquilos». En su interior se respira una sensación de desahogo y de libertad visuales tanto en el sentido horizontal como en el vertical. En todo el conjunto, sus diseñadores han conseguido acertados efectos, con la iluminación, y con la textura y color de los materiales empleados.

  2. Casa para la playa, New Jersey

    Directory of Open Access Journals (Sweden)

    Breuer, Marcel

    1964-03-01

    Full Text Available The McMullan house, built on the beach, has been designed to be inhabited all the year round. Basically this building is a rectangular block, lifted above the dunes on a framework of timber columns and beams. The ground floor contains the entrance hall, the guest room or servant's quarters, including a bath room, and a shower room which can be reached separately from the beach. The second floor is taken up with the main living quarters, and the second floor contains the bedrooms. The northern and southern sides have few windows, whilst the eastern and western sides have balconies protected with sliding and Venetian blinds, which in addition to supplying an effective protection against the sun, give the house a pleasant sense of secluded intimacy. The blinds are made of wood, and are painted dark brown. Doors and windows are also made of wood, but painted white. This beautiful house on the New Jersey coast exhibits in a marked degree the sculptural quality of architecture, a three dimensional plasticity, which is often neglected in many buildings of the more simple kind. Marcel Breuer has succeeded in making each of the facades of this elementary boxlike design have an interest of its own, by playing with their colour, light and shade effects, texture and combination of materials.La casa McMullan, construida en la playa, está proyectada para ser habitada durante todo el año. En esencia es un bloque paralelepipédico, elevado sobre las dunas y sustentado por un sistema de columnas y vigas de madera vistas, tanto en el interior como en el exterior. Su planta baja alberga: la entrada principal, habitación de huéspedes o de servicio con baño y una ducha con acceso desde la playa. El primer piso agrupa las dependencias nobles. Y el segundo, la zona de dormitorios. Las fachadas norte y sur presentan pocos huecos al exterior; y las este y oeste disponen de galerías con persianas correderas y celosías, que, además de proporcionar intimidad a la

  3. Ventaja de jugar en casa en voleibol de alto rendimiento

    Directory of Open Access Journals (Sweden)

    Rui Marcelino

    2009-01-01

    Full Text Available En este estudio se ha pretendido estudiar la ventaja en casa en el Voleibol de alto rendimiento, apoyándonos en las estadísticas de los partidos que más pueden explicar ese fenómeno. Se han analizado 65.949 acciones de juego seleccionadas de la Liga Mundial 2005. El instrumento de observación que se ha elaborado es una combinación de formato de campo con sistemas de categorías. Los datos se han obtenido mediante el "Volleyball Information System" y se han analizado mediante la prueba t de Student, y la prueba ji-cuadrado. Los resultados demuestran que hay ventaja en casa en Voleibol (57,5% de victorias jugando en casa. Las estadísticas del ataque (t= 2.49, p = 0.01, del servicio (t= -2.18, p= 0.03, de la recepción (t= 16.74, p<0.001 y de la distribución (t= 2.03, p= 0.04 muestran rendimientos superiores para los equipos que juegan en casa. No se han encontrado diferencias en el rendimiento del bloqueo (t= -0.25, p= 0.80 y la defensa (t= 0.11, p= 0.92 entre los juegos disputados en casa y los disputados fuera.

  4. Archivo histórico de la Casa de Moneda

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1996-09-01

    Full Text Available El Banco de la República posee una de las colecciones más interesantes a nivel histórico y económico del país: el archivo de la Casa de Moneda que data de 1620. Su descripción y clasificación se comenzó en 1991 teniendo como base la Historia de la Casa de Moneda, de Antonio Barriga Villalba -administrador de la Casa en los años cincuenta-, siendo la única obra que se ha publicado hasta la fecha. La clasificación se ha realizado con base en la Norma general para la descripción archivística elaborada por el Archivo General de la Nación.

  5. Establishing CASA as an evidence-based practice.

    Science.gov (United States)

    Lawson, Jennifer; Berrick, Jill Duerr

    2013-01-01

    In this article the authors examine the evidentiary status of the Court Appointed Special Advocates (CASA) program through a review of current research findings and a critical analysis of the study methodologies used to produce those findings. Due to the equivocal research findings and widespread methodological weaknesses (most notably selection bias) in the literature base, it is determined that there is not currently enough evidence to establish CASA as an evidence-based practice. In spite of the challenges to the feasibility of such research, a future research agenda is suggested that calls for the execution of large randomized controlled trials in order to produce findings that will inform a deeper understanding of CASA effectiveness in improving child outcomes.

  6. Computer-assisted sperm analysis (CASA): capabilities and potential developments.

    Science.gov (United States)

    Amann, Rupert P; Waberski, Dagmar

    2014-01-01

    Computer-assisted sperm analysis (CASA) systems have evolved over approximately 40 years, through advances in devices to capture the image from a microscope, huge increases in computational power concurrent with amazing reduction in size of computers, new computer languages, and updated/expanded software algorithms. Remarkably, basic concepts for identifying sperm and their motion patterns are little changed. Older and slower systems remain in use. Most major spermatology laboratories and semen processing facilities have a CASA system, but the extent of reliance thereon ranges widely. This review describes capabilities and limitations of present CASA technology used with boar, bull, and stallion sperm, followed by possible future developments. Each marketed system is different. Modern CASA systems can automatically view multiple fields in a shallow specimen chamber to capture strobe-like images of 500 to >2000 sperm, at 50 or 60 frames per second, in clear or complex extenders, and in information for ≥ 30 frames and provide summary data for each spermatozoon and the population. A few systems evaluate sperm morphology concurrent with motion. CASA cannot accurately predict 'fertility' that will be obtained with a semen sample or subject. However, when carefully validated, current CASA systems provide information important for quality assurance of semen planned for marketing, and for the understanding of the diversity of sperm responses to changes in the microenvironment in research. The four take-home messages from this review are: (1) animal species, extender or medium, specimen chamber, intensity of illumination, imaging hardware and software, instrument settings, technician, etc., all affect accuracy and precision of output values; (2) semen production facilities probably do not need a substantially different CASA system whereas biology laboratories would benefit from systems capable of imaging and tracking sperm in deep chambers for a flexible period of time

  7. 78 FR 19066 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MI CASA; Invitation for...

    Science.gov (United States)

    2013-03-28

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2013 0035] Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MI CASA; Invitation for Public Comments AGENCY... CASA is: Intended Commercial Use of Vessel: Passenger charters. Geographic Region: Massachusetts, New...

  8. A casa em verso e prosa: Canções, poesias e subjetividade do conceito de casa

    OpenAIRE

    CORDEIRO, Nilson Da Rocha

    2015-01-01

    Ao iniciar estas reflexões sobre a moradia, buscamos destacar o aspecto basilar da casa – enquanto abrigo – para o desenvolvimento do indivíduo, da cidade e da sociedade. Com o objetivo de investigar as concepções de casa, como esse termo é percebido e qual a sua real importância na constituição do indivíduo, utilizamos como porta de acesso para esse universo as representações feitas sobre a casa e o lar encontradas em canções e poemas que abordam a temática, seja de forma explicita ou implíc...

  9. 77 FR 5998 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2012-02-07

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A... proposed to correct an unsafe condition for the specified products. The MCAI states: EADS-CASA received... address this condition, EADS-CASA has developed an engine condition control cable P/N 35-56382-0005 with...

  10. 75 FR 68185 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2010-11-05

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A...) that were, at that moment, defined in issue C of EADS-CASA document DT-0-C00-05001. That document has... implementation of the revised Fuel Airworthiness Limitations contained in issue D of EADS- CASA document DT-0-C00...

  11. Casa Veba en Dusseldorf - Alemania Federal

    Directory of Open Access Journals (Sweden)

    Hentrich, Helmut

    1977-03-01

    Full Text Available Designed for offices to be let, and made up of a buried part, occupying 6,500 m2 of the site, and a tower, cross-shaped plan, twelve storeys high. There are 200 parking spaces in the basement. The semibasement is occupied by part of the technical services of the house and a series of ancillary and supply quarters. Access to the building is through the ground floor, which comprises: rooms for meetings and lectures, electronic data processing installation and administrative offices. The offices to be let are distributed in the nine following floors. Finally, the coronation floor houses the remaining technical services of the building. In the main nucleus, vertical communication means have been arranged and the facilities of each floor. Construction has been performed by means of a reinforced concrete structure, with supports in the periphery of the building to leave the office areas free of obstacles. Flooring consists of ribbed slabs. Bracing against the wind is entrusted to the main nucleus, also of reinforced concrete. The building has a suitable series of technical installations, the varied range of measures adopted being worth mentioning, to achieve suitable sound-absorbing in each of the working premises.Está destinado a oficinas de alquiler, y se compone de un cuerpo enterrado, que ocupa los 6.500 m2 del solar, y una torre, de planta cruciforme, de doce alturas. En el sótano se han distribuido 200 plazas de aparcamiento. El semisótano lo ocupan parte de los servicios técnicos de la casa, y una serie de dependencias auxiliares y de suministro. El acceso al edificio es por la planta baja, que consta de: salas para reuniones y conferencias, instalación de elaboración electrónica de datos, y oficinas administrativas. En las nueve plantas siguientes se distribuyen las oficinas de alquiler. Por último, la planta de coronación aloja los restantes servicios técnicos del edificio. En el núcleo central se han dispuesto los medios

  12. Iowa CASAS Pilot Project Reports: An Initial Evaluation of CASAS Effectiveness in Iowa's Adult Basic Education Programs.

    Science.gov (United States)

    Strom, Mary L.

    In fall 1992, the Iowa Department of Education began pilot tests of the Comprehensive Adult Student Assessment System (CASAS), an assessment system evaluating reading, math, and problem solving in a life skills context for adult remedial programs. This document provides reports from the nine community colleges that served as test sites, describing…

  13. Computer-aided sperm analysis (CASA) in the medical laboratory: CASA in diagnostic andrology and assisted conception.

    Science.gov (United States)

    Tomlinson, Mathew J; Naeem, Asad

    2018-03-21

    CASA has been used in reproductive medicine and pathology laboratories for over 25 years, yet the 'fertility industry' generally remains sceptical and has avoided automation, despite clear weaknesses in manual semen analysis. Early implementers had difficulty in validating CASA-Mot instruments against recommended manual methods (haemocytometer) due to the interference of seminal debris and non-sperm cells, which also affects the accuracy of grading motility. Both the inability to provide accurate sperm counts and a lack of consensus as to the value of sperm kinematic parameters appear to have continued to have a negative effect on CASA-Mot's reputation. One positive interpretation from earlier work is that at least one or more measures of sperm velocity adds clinical value to the semen analysis, and these are clearly more objective than any manual motility analysis. Moreover, recent CASA-Mot systems offer simple solutions to earlier problems in eliminating artefacts and have been successfully validated for sperm concentration; as a result, they should be viewed with more confidence in relation to motility grading. Sperm morphology and DNA testing both require an evidence-based consensus and a well-validated (reliable, reproducible) assay to be developed before automation of either can be of real clinical benefit.

  14. Deformation near the Casa Diablo geothermal well field and related processes Long Valley caldera, Eastern California, 1993-2000

    Science.gov (United States)

    Howle, J.F.; Langbein, J.O.; Farrar, C.D.; Wilkinson, S.K.

    2003-01-01

    Regional first-order leveling lines, which extend from Lee Vining, CA, to Tom's Place, CA, have been surveyed periodically since 1957 by the U.S. Geological Survey (USGS), the National Geodetic Survey (NGS), and Caltrans. Two of the regional survey lines, or leveling networks, intersect at the Casa Diablo geothermal well field. These leveling networks, referenced to a distant bench mark (C916) near Lee Vining, provide time-series vertical control data of land-surface deformation that began around 1980. These data are also useful for delineating localized subsidence at Casa Diablo related to reservoir pressure and temperature changes owing to geothermal development that began in 1985. A comparison of differences in bench-mark elevations for five time periods between 1983 and 1997 shows the development and expansion of a subsidence bowl at Casa Diablo. The subsidence coincides spatially with the geothermal well field and temporally with the increased production rates and the deepening of injection wells in 1991, which resulted in an increase in the rate of pressure decline. The subsidence, superimposed on a broad area of uplift, totaled about 310 mm by 1997. The USGS established orthogonal tilt arrays in 1983 to better monitor deformation across the caldera. One tilt array (DBR) was established near what would later become the Casa Diablo geothermal well field. This array responded to magmatic intrusions prior to geothermal development, tilting away from the well field. With the start of geothermal fluid extraction in 1985, tilt at the DBR array reversed direction and began tilting into the well field. In 1991, geothermal power production was increased by a factor of four, and reservoir pressures began a period of steep decline. These changes caused a temporary three-fold increase in the tilt rate. The tilt rate became stable in 1993 and was about 40% lower than that measured in 1991-1992, but still greater than the rates measured during 1985-1990. Data from the

  15. La construcción de un cielo: Casa Goycoolea

    Directory of Open Access Journals (Sweden)

    Rodrigo Lagos Vergara

    1995-12-01

    Full Text Available La casa se ubicará en una de las cuencas que deja el cerro Caracol a lo largo del río Bío-Bío en Concepción. El terreno es de dimensiones modestas y es un sitio entre medianeros que se encuentra dominado por vistas de las casas vecinas. La calle Los Copihues, hacia la que da el predio, es de tráfico limitado salvo los días de fiesta debido a que da acceso al Country Club de la ciudad. Esto determina que las únicas vistas apetecibles desde el sitio sean el horizonte de cerros, el cielo, y el acceso al Country Club, ya que por ese punto se abre el espacio y se accede.

  16. El silencio en la Casa de la Reina

    Directory of Open Access Journals (Sweden)

    María del Carmen Simón Palmer

    2013-07-01

    Full Text Available Durante el reinado de los Austrias se impusieron duras reglas de etiqueta en la Casa de la Reina. La llegada de éstas supuso la sumisión tanto de la reina como de sus meninas.Sin embargo, muchos de los escritos de esta época dan una falsa imagen de felicidad, de mujeres que asisten continuamente a fiestas y banquetes, aunque una lectura más atenta demuestra que lo hacen sólo como adorno. Un sentimiento de sumisión, de vida en cautiverio, de miedo a la maternidad, y de agobio por unas normas que regulan la conversación con los hombres, y cualquier gesto de las habitantes de la Casa de la Reina, incluido el matrimonio por conveniencia, se convierten en artífices del continuo silencio femenino.

  17. Differential compaction mechanism for earth fissures near Casa Grande, Arizona.

    Science.gov (United States)

    Jachens, R.C.; Holzer, T.L.

    1982-01-01

    Precise gravity measurements indicate that earth fissures or tension cracks caused by ground-water withdrawal within a 10km2 area SE of Casa Grande are associated with relief on the buried interface between the alluvial aquifer and underlying bedrock. These relations suggest that the fissures are forming in response to localized differential compaction caused by localized variations of aquifer-system thickness. -from Authors

  18. La Casa del Fascio di Como e le sue

    Directory of Open Access Journals (Sweden)

    Cristina Casero

    2010-01-01

    Full Text Available Giuseppe Terragni’s ‘Casa del Fascio’ in Como undoubtedly stands out as a masterpiece of Italian ‘Razionalismo’, though inflected according to the architect’s peculiar language. However, as rightly noted by Diane Ghirardo, a merely formal analysis of the building is not plausible. The underlying meaning and the very value of the ‘Casa del Fascio’ are fully perceivable only by taking into consideration the original project, without overlooking the opulent ‘decoration’ specifically intended as an integral part of the building. That includes Marcello Nizzoli’s photomechanical panels for the façade, built but never actually put in place, and Mario Radice’s works for the ‘Sala del Direttorio’ and the ‘Salone delle Adunate’, both destroyed in the immediate post-war; also worth mentioning are the decorative projects by the architect himself for the ‘Sala Federale’ and the room entitled to Gigi Maino. From such a perspective, the ‘Casa del Fascio’ appears under a renovated light, as a building of great functional value, but also as a very interesting communicational device.

  19. Preventive conservation applied to "Casa dos Patudos" oil painting collection

    Directory of Open Access Journals (Sweden)

    Mafalda Fernandes

    2016-01-01

    Full Text Available The main objective of this work was the identification of specific risks affecting the collection of oil paintings in the historic house "Casa dos Patudos" (Alpiarça, Portugal and the development of mitigation strategies for the risks encountered. The methodology used was proposed by the Canadian Conservation Institute. The results showed that the main risks affecting this collection result from incorrect handling, increase in paint detachment due to the maintenance of paintings with paint lifting on display, occurrence of insect pests, high fluctuations in relative humidity and, excessive exposure to ultraviolet radiation. Several preventive conservation strategies to mitigate these risks are proposed.

  20. Casa en Sierra Morena Huarochirí, Perú

    OpenAIRE

    Doblado, Juan Carlos

    2014-01-01

    La horizontalidad en la conformación de esta casa busca acentuar su relación con el paisaje de la cordillera de Los Andes. Se organiza en dos volúmenes horizontales paralelos, desfasados y semitransparentes, que se clavan a la pendiente. Al interior, la vivienda se caracteriza por poder integrar sus espacios a través de mamparas corredizas. En el primer cuerpo se encuentran los espacios comunes, la cocina y dormitorios, mientras que en el segundo volumen se sitúan un estar familiar y los dorm...

  1. Casa Elina”: el encuentro como oportunidad

    OpenAIRE

    Saavedra, Caudia; Martinez Goya, Milagros

    2017-01-01

    El dispositivo “Casa Elina” nace en abril del año 2014, como un servicio integrado entre el Hospital Subzonal Especializado “Elina de la Serna de Montes de Oca” y la Subsecretaría de Salud Mental y Adicciones, ahora Subsecretaría de Determinantes Sociales de la Salud y la Enfermedad Física, Mental y de las Adicciones del Ministerio de Salud de la provincia de Buenos Aires. Surge con la impronta de ser un dispositivo innovador en relación al formato tradicional hospitalario, a la vez de encuad...

  2. Dos casas en el cerro Pochoco: Lo Barnechea, Chile

    OpenAIRE

    Carreño, Mario; Sartori, Piera

    2009-01-01

    A partir de la remodelación de una vivienda, se generan dos casas superpuestas que comparten el mismo volumen y una torre-terraza asomada a un cajón cordillerano en la periferia de la ciudad de Santiago. La dimensión vertical de la montaña aparece en los interiores, orientados hacia el suelo inmediato y las vistas lejanas. Starting with the renovation of a dwelling, two superimposed houses are generated that share the same volume, a tower-terrace leaning out of a mountain valley in the out...

  3. Recent results from the CASA-MIA experiment

    International Nuclear Information System (INIS)

    Matthews, J.

    1995-01-01

    Results from the CASA-MIA cosmic ray experiment are presented. I discuss the apparatus and its performance, including new results on the identification of the shadows of the sun and moon used to determine the angular resolution. Limits on the emission of 100 TeV γ-rays from the Crab Nebula are well below extrapolations from TeV observations. A search for diffuse γ-rays from the Galactic plane give limits approaching some recent predictions. copyright 1995 American Institute of Physics

  4. Plant remains of archaeological site Casa Vieja, Callango (Ica

    Directory of Open Access Journals (Sweden)

    José Roque

    2013-06-01

    Full Text Available A paleoethnobotanical study was carried out at the Middle Horizon archaeological site of Casa Vieja, located in Callango within the Lower Ica Valley. A total of 23 species were identified, all determined to be of the Magnoliopyta Division, 78 % (or 18 species were Magnoliopsid and 22% (or 15 species Liliopsid. The Fabaceae are the best represented family with 6 species. Most of the analyzed samples correspond to seeds of Gossypium barbadense “cotton”. Seventy percent of the species were probably used as food; 48% for artifact-making and construction and 52% for medicinal and curative purposes.

  5. eXtended CASA Line Analysis Software Suite (XCLASS)

    Science.gov (United States)

    Möller, T.; Endres, C.; Schilke, P.

    2017-02-01

    The eXtended CASA Line Analysis Software Suite (XCLASS) is a toolbox for the Common Astronomy Software Applications package (CASA) containing new functions for modeling interferometric and single dish data. Among the tools is the myXCLASS program which calculates synthetic spectra by solving the radiative transfer equation for an isothermal object in one dimension, whereas the finite source size and dust attenuation are considered as well. Molecular data required by the myXCLASS program are taken from an embedded SQLite3 database containing entries from the Cologne Database for Molecular Spectroscopy (CDMS) and JPL using the Virtual Atomic and Molecular Data Center (VAMDC) portal. Additionally, the toolbox provides an interface for the model optimizer package Modeling and Analysis Generic Interface for eXternal numerical codes (MAGIX), which helps to find the best description of observational data using myXCLASS (or another external model program), that is, finding the parameter set that most closely reproduces the data. http://www.astro.uni-koeln.de/projects/schilke/myXCLASSInterface A copy of the code is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/598/A7

  6. Los dos mundos en Casa Malaparte Isla de Capri, Italia

    Directory of Open Access Journals (Sweden)

    Gloria Saravia Ortiz

    2010-12-01

    Full Text Available En Casa Malaparte lo doméstico y lo monumental se encuentran para dar paso a una de las viviendas más interesantes, cuestionadas y sugestivas de la modernidad. Proyecto “singular” cuanto entra en directa relación con la imponente naturaleza del lugar, esta obra propone el sentido doméstico de una vivienda cotidiana y simultáneamente una idea de lo monumental, lo cual le otorga un carácter casi mítico. El artículo recorre esta casa y su particular espacialidad entre lo expuesto y lo oculto; una vivienda capaz de reflejar la personalidad y la experiencia en el exilio de su propietario, el escritor italiano Curzio Malaparte, quien buscaba habitar una residencia hermética que, a su vez, satisficiera su deseo de espacio. Bajo la luz y la amplitud del paisaje de Capri que recibe el solarium de la vivienda, dominando el mar, el arquitecto italiano Adalberto Libera propone simultáneamente la opacidad y el hermetismo de una obra que desvela la soledad y permanece en la memoria como ilustración de la cultura mediterránea.

  7. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  8. Collective memory and the Casa della Memoria : on the potential and risk of instant patina

    NARCIS (Netherlands)

    Black, S.E.; Jenniskens, D.P.H.

    2017-01-01

    This article investigates the way in which instant patina is employed in the Casa della Memoria (House of Memory) in Milan by Baukuh (2015), with reference to Maurice Halbwachs’s theory of collective memory. It observes that the Casa della Memoria uses instant patina with the aim of solidifying a

  9. Aligning CASAS Competencies and Assessments to Basic Skills Content Standards. Second Edition

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2009

    2009-01-01

    Since its inception, the Comprehensive Adult Student Assessment System (CASAS) has focused on teaching and assessing basic skills in contexts that are relevant and important to adult learners. CASAS has developed and continues to refine a highly formalized hierarchy of competencies, the application of basic skills that adults need to be fully…

  10. Casa de la Esperanza: A Case Study of Service Coordination at Work in Colorado.

    Science.gov (United States)

    Franquiz, Maria E.; Hernandez, Carlota Loya

    This chapter describes how a federally funded farmworker housing facility in northern Colorado--Casa de la Esperanza--has changed the lives of migrant students and their families. The history of migrant workers in Colorado is described, as well as the struggle to construct a permanent farmworker housing facility. Casa was built in Boulder County,…

  11. Central and South America GPS geodesy - CASA Uno

    Science.gov (United States)

    Kellogg, James N.; Dixon, Timothy H.

    1990-01-01

    In January 1988, scientists from over 25 organizations in 13 countries and territories cooperated in the largest GPS campaign in the world to date. A total of 43 GPS receivers collected approximately 590 station-days of data in American Samoa, Australia, Canada, Colombia, Costa Rica, Ecuador, New Zealand, Norway, Panama, Sweden, United States, West Germany, and Venezuela. The experiment was entitled CASA Uno. Scientific goals of the project include measurements of strain in the northern Andes, subduction rates for the Cocos and Nazca plates beneath Central and South America, and relative motion between the Caribbean plate and South America. A second set of measurements are planned in 1991 and should provide preliminary estimates of crustal deformation and plate motion rates in the region.

  12. Residuos peligrosos hospitalarios en casa: una amenaza emergente.

    Directory of Open Access Journals (Sweden)

    Luz Divia Mejía-Reales

    2016-06-01

    Full Text Available Objetivo: describir el manejo de residuos peligrosos hospitalarios generados en los domicilios por usuarios con enfermedades crónicas de una institución prestadora de servicios de salud en la ciudad de Valledupar, Colombia. Materiales y Métodos: estudio de enfoque cuantitativo, la muestra estuvo conformada por 85 usuarios con enfermedades crónicas que cumplieran con los criterios de inclusión, a quienes se les aplicó un cuestionario sobre manejo de residuos peligrosos hospitalarios en casa. Resultados: la población encuestada estuvo expuesta a riesgos relacionados con el manejo de agujas un 40% de los diabéticos, el 55% de quienes padecen enfermedad renal, en contacto con líquido peritoneal, y los usuarios con enfermedad pulmonar obstructiva crónica 36% presentaron reacciones anafilácticas. Además se encontró que el 66% de la población no tiene conocimientos acerca del manejo de estos residuos, cuál es el almacenamiento, recolección, transporte, tratamiento y/o disposición final de los mismos. Conclusión: el estudio reveló que existe una problemática relacionada con el proceso integral de los residuos peligrosos hospitalarios, debido a que la población generadora de estos pertenecen a estratos medios - bajos y asumir la totalidad de los gastos generados es poco viable, además no está capacitada adecuadamente, por tal razón resultó pertinente la elaboración de un manual para el manejo de residuos peligrosos hospitalarios generados en casa, para instruir sobre actividades que realizan estos usuarios, buscando disminuir el impacto en la salud y el ambiente derivados de la producción de estos desechos.

  13. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.

    Science.gov (United States)

    Ulbricht, Anna; Gehlert, Sebastian; Leciejewski, Barbara; Schiffer, Thorsten; Bloch, Wilhelm; Höhfeld, Jörg

    2015-01-01

    Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscles to degrade mechanically damaged cytoskeleton proteins. Moreover, repeated resistance exercise during 4 wk of training led to an increased expression of CASA components. In human skeletal muscle, CASA apparently acts as a central adaptation mechanism that responds to acute physical exercise and to repeated mechanical stimulation.

  14. Casa de parto: simbologia e princípios assistenciais Casa de parto: simbología y principios de asistencia Birth center: symbols and assistance -related principles

    Directory of Open Access Journals (Sweden)

    Luiza Akiko Komura Hoga

    2004-10-01

    Full Text Available A primeira Casa de Parto vinculada ao Programa Saúde da Família possui simbologia específica. Objetivou-se identificar os símbolos que permeiam as idéias, crenças, valores e práticas e os princípios que orientam a assistência prestada na Casa de Parto. O método de pesquisa foi a etnografia e a história oral temática, o recurso empregado para entrevistar enfermeiras obstétricas da Casa. Resultados: A Casa possui o valor simbólico da inovação da assistência ao parto e o cuidado humanizado à gestante é o princípio que norteia as práticas. Considerações finais: A simbologia da Casa e as práticas de cuidado desenvolvidas constituem referência às demais Casas de parto em proposição no Brasil e devem ser conhecidas pelas enfermeiras obstétricas.La primera Casa de Parto vinculada al Programa de Salud de la Familia posee simbología específica. El Objetivo de esta encuesta es identificar los símbolos que atraviesan las ideas, creencias, valores y prácticas así como los principios que orientan la asistencia de la casa de parto. El método de la encuesta fue la etnografía y la historia oral temática fue el recurso usado para entrevistar a enfermeras obstétricas de esta Casa. Resultados: La Casa posee el valor simbólico de la innovación de la asistencia al parto y el cuidado humanizado es el principio que orienta las prácticas de enfermería. Consideraciones finales: La simbología de la Casa y las prácticas de asistencia al parto desarrolladas en esta casa constituyen referencia de las demás casas de parto en Brasil y las deben conocer las enfermeras obstétricas.The first Birth Center of the Family Health Program has specific symbols. The purpose was the identification of symbols that permeate the ideas, beliefs, values, practices, and principles that guide the assistance given at the Birth Center. Ethnography was the research method; thematic oral history was the resource employed to interview obstetric nurses in

  15. The politics of publication: Bartolomé de las Casas's 'the devastation of the Indies'

    Directory of Open Access Journals (Sweden)

    Rolena Adorno

    1993-07-01

    Full Text Available [First paragraph] The Devastation of the Indies: A Brief Account. BARTOLOMÉ DE LAS CASAS. Translated by Herma Briffault. Introduction by Bill M. Donovan. Baltimore: Johns Hopkins University Press, 1992. 138 pp. (Paper US$ 11.95 The 1992 Johns Hopkins University Press publication of Bartolom? de las Casas's The Devastation of the Indies: A Brief Account has been, I am told, a commercial success. Regrettably, it is a scholarly failure. The translation - a reprint of a 1974 version - is so inaccurate that it barely deserves to go by the name, and the introductory essay that accompanies it repeats the old clich?s and familiar misunderstandings that one commonly reads about Las Casas's life and work. The shortcomings of both the translation and the introduction could have been overcome by a deeper engagement with Las Casas's works and greater attention to basic information about sixteenth-century Spanish history.

  16. Galicia ja galeegid / Arturo Casas Vales ; interv. Jüri Talvet

    Index Scriptorium Estoniae

    Vales, Arturo Casas

    2002-01-01

    Galiitsia kirjandusteoreetiku ja luuletaja ja A. Casas Valesi (sünd. 1958) arvamus eesti ja galeegi kirjanduse ning kultuuri sarnasustest ja erinevustest, galeegi keele sotsiaalsest kohast ja kirjanduse arengust

  17. Casas y bodegas de Florida, San Ignacio, Ninhue, Ranquil y Coelemu

    Directory of Open Access Journals (Sweden)

    Gonzalo Cerda Brintrup

    1990-12-01

    A continuación presentamos algunos de estos ejemplos: Casa principal del Fundo "Las Lajuelas" de Florida; Vivienda en Ranquil; Bodega de vinos "El Roble" en las cercanías de Coelemu y una vivienda urbana de Ninhue.

  18. Crop adapted spray application (CASA) - precise and safe plant protection in fruit growing

    NARCIS (Netherlands)

    Doruchowski, G.; Balsari, P.; Marucco, P.; Zande, van de J.C.; Wenneker, M.

    2012-01-01

    The Crop Adapted Spray Application (CASA) system for orchards integrates disease detection based on reflectance imaging, crop identification with ultrasonic sensors, wind measurement and DGPS navigation. Through the automatic adjustment of spray application parameters according to the crop

  19. El sentido cultural del cuidado en casa del enfermo

    Directory of Open Access Journals (Sweden)

    Marina Sánches-Sanabria

    2008-12-01

    Full Text Available Esta investigación tiene un diseño cualitativo descriptivo, transversal para comprender las diferencias existentes en los conocimientos, actitudes y prácticas influidas por la percepción o sentido cultural de cuidar del cuidador primario, como elemento básico para caracterizar elementos culturales presentes en el ambiente de cuidado al enfermo o discapacitado que está en casa a través de la indagación profunda de la percepción y sentimientos que tiene tanto el cuidador primario como el ser cuidado en casa. Se realizó con los usuarios inscritos del Programa de Promoción y Prevención de la indagación profunda de la percepción y sentimientos Universidad Popular del Cesar (IPS-UPC de los enfermos crónicos y discapacitados a nivel comunitario del grupo extramural de la comuna cinco y del Hospital Eduardo Arredondo Daza de la ciudad de Valledupar, Colombia. El valor de realizar este proyecto, está en desocultar los múltiples significados que en la realidad vivida por los seres cuidadores primarios y en los seres cuidados; son esas distintas formas de percibir la existencia, influido por el conocimiento de lo ancestral, los sentimientos y la sabiduría de la cultura que cada uno posee para expresarse en las múltiples formas que el cuidado lo acontece y lo requiere para dar el sentido cultural característico y diferenciado que se percibe en el modo de cuidar y la satisfacción de quien lo recibe y lo ofrece. Este aspecto fue valioso para la comunidad académica del programa de enfermería, porque ubicó epistémicamente la transculturalidad del cuidado como una mirada y forma de enseñar transdisciplinariamente, enseñando y ofreciendo el cuidado desde la cultura, sentimientos y pensamientos del ser cuidado para el mantenimiento de la vida y la salud, en la que estudiantes de enfermeria desde sus primeras experiencias formativas deben incursionar en la intervención holística que se requiere en el cuidado de la salud y de la vida.

  20. Tecnologias do lar e pedagogias de gênero: representações da “dona de casa ideal” na revista Casa & Jardim (anos 1950 e 1960)

    OpenAIRE

    Padilha, Ana Caroline de Bassi

    2014-01-01

    Neste trabalho, temos como objetivo investigar as associações entre tecnologias domésticas e tipos de feminilidades na revista Casa & Jardim como mídia de pedagogias de gênero. O recorte de estudo tem como foco os discursos textuais e imagéticos sobre tecnologias do lar veiculados na revista Casa & Jardim durante as décadas de 1950 e 1960. Neste período, as revistas direcionadas para públicos femininos buscavam criar uma identificação das mulheres com o espaço e o consumo domésticos, apresent...

  1. Validation of a novel computer-assisted sperm analysis (CASA) system using multitarget-tracking algorithms.

    Science.gov (United States)

    Tomlinson, Mathew James; Pooley, Karen; Simpson, Tracey; Newton, Thomas; Hopkisson, James; Jayaprakasan, Kannamanadias; Jayaprakasan, Rajisha; Naeem, Asad; Pridmore, Tony

    2010-04-01

    To determine the accuracy and precision of a novel computer-assisted sperm analysis (CASA) system by comparison with existing recommended manual methods. Prospective study using comparative measurements of sperm concentration and motility on latex beads and immotile and motile sperm. Tertiary referral fertility center with strong academic links. Sperm donors and male partners of couples attending for fertility investigations. None. Achievement of Accubead target value for high and low concentration suspensions. Repeatability as demonstrated by coefficients of variation and intraclass correlation coefficients. Correlation and limits of agreement between CASA and manual methods. The CASA measurements of latex beads and sperm concentrations demonstrated a high level of accuracy and repeatability. Repeated Accubead measurements attained the required target value (mean difference from target of 2.61% and 3.71% for high- and low-concentration suspensions, respectively) and were highly reproducible. Limits of agreement analysis suggested that manual and CASA counts compared directly could be deemed to be interchangeable. Manual and CASA motility measurements were highly correlated for grades a, b, and d but could not be deemed to be interchangeable, and manual motility estimates were consistently higher for motile sperm. The novel CASA system was able to provide semen quality measurements for sperm concentration and motility measurements which were at least as reliable as current manual methods. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  2. Teaching Cases in Management - Sabor de Casa Restaurant

    Directory of Open Access Journals (Sweden)

    Nilda Maria de Clodoaldo Pinto Guerra Leone

    2009-01-01

    Full Text Available Small family businesses present a series of peculiarities and challenges, especially when it comes to the management of human resources. This case describes the true situation of an enterprise, Restaurante Sabor de Casa, and portrays the relationship between the founder and successor and its consequences on the practice and policy of human resources. The story is told from the point of view of the successor, who thinks about the situation of the company and his deep involvement in the dynamic and complex stage of working with his mother, the founder of the company, whose performance is that of an entrepreneur, albeit a traditional one. It shows his reflections on the directions the company has taken, the opinions of employees, based on research conducted in 2006 by university students and their questions about the way the contributions of the employees are managed, mainly by recognizing their importance for both the present and the future of the company. This case deals with the complexity of the management of human resources in a family organizational environment.

  3. Gerrit Rietveld. Casas después de la Schroeder

    Directory of Open Access Journals (Sweden)

    Rafael García

    1997-07-01

    Full Text Available Las historias de la arquitectura moderna han incidido una y otra vez en un reducido número de obras que por su insistente atención, han llegado a convertirse en hitos imprescindibles. Entre estos edificios canónicos y prácticamente obligados, está la célebre casa Schröder-Schräder (1924' del arquitecto holandés Gerrit Rietveld. Ampliamente conocida por el público interesado, su gran popularidad ha tenido sin embargo, el efecto de dejar en segundo plano el resto de su obra arquitectónica. A ello se debe añadir además, el hecho de que su trayectoria está fundamentalmente asociada al movimiento neoplasticista, lo que ha tenido por resultado desviar la atención de una obra posterior, más difícilmente clasificable. Sin embargo, ello no significa que dicha obra sea en absoluto carente de atractivo.

  4. A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature.

    Science.gov (United States)

    Seo, Min-Seob; Jang, Sumin; Kim, Hyunwoo

    2018-03-16

    A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (-40 to 10 °C) was required.

  5. Description and evaluation of the CASA dual-Doppler system

    Science.gov (United States)

    Martinez, Matthew

    2011-12-01

    Long range weather surveillance radars are designed for observing weather events for hundreds of kilometers from the radar and operate over a large coverage domain independently of weather conditions. As a result a loss in spatial resolution and limited temporal sampling of the weather phenomenon occurs. Due to the curvature of the Earth, long-range weather radars tend to make the majority of their precipitation and wind observations in the middle to upper troposphere, resulting in missed features associates with severe weather occurring in the lowest three kilometers of the troposphere. The spacing of long-range weather radars in the United States limits the feasibility of using dual-Doppler wind retrievals that would provide valuable information on the kinematics of weather events to end-users and researchers. The National Science Foundation Center for Collaborative Adapting Sensing of the Atmosphere (CASA) aims to change the current weather sensing model by increasing coverage of the lowest three kilometers of the troposphere by using densely spaced networked short-range weather radars. CASA has deployed a network of these radars in south-western Oklahoma, known as Integrated Project 1 (IP1). The individual radars are adaptively steered by an automated system known as the Meteorological Command and Control (MCC). The geometry of the IP1 network is such that the coverage domains of the individual radars are overlapping. A dual-Doppler system has been developed for the IP1 network which takes advantage of the overlapping coverage domains. The system is comprised of two subsystems, scan optimization and wind field retrieval. The scan strategy subsystem uses the DCAS model and the number of dual-Doppler pairs in the IP1 network to minimizes the normalized standard deviation in the wind field retrieval. The scan strategy subsystem also minimizes the synchronization error between two radars. The retrieval itself is comprised of two steps, data resampling and the

  6. Casa Pruss. Buenos Aires - República Argentina

    Directory of Open Access Journals (Sweden)

    Álvarez, M. Roberto

    1974-12-01

    Full Text Available The building ¡s situated on a 910 m2 Lshaped site. It consists of three storeys and terrace: — in the basement are located: a garage with space for two cars, W.C., storage rooms and boiler room; — the ground floor comprises: hall-drawing room, dining-room and W.Cs. as well as the terraces; — the first floor contains: the family bedrooms, the staff bedrooms, the bathrooms and the laundry-and ironing room. A spiral staircase connects the three storeys and the terrace; another main staircase leads from the reception floor to the first. In front of as well as behind the house there is a garden. The structure is of metal with side walls and foundation of concrete. The remaining materials, interior as well as exterior, are of highest quality and easy to maintain.Está emplazada en una parcela de unos 910 m2, con forma de L. Consta de tres plantas y terraza: — el sótano comprende: un garaje para dos automóviles, aseo, almacenes y cuarto de calderas-máquinas; — en la baja se distribuyen: vestíbulo-salón, comedor de diario y servicios, además de las terrazas; — la planta primera agrupa: los dormitorios familiares, los de servicio, los baños y el cuarto de lavado y plancha. Una escalera curva comunica las tres plantas y la terraza; otra escalera, más aparente, enlaza la planta noble con la primera. Jardín delante y detrás de la casa. La estructura es metálica, con muros laterales y de fondo de hormigón. El resto de los materiales, en interiores y exteriores, son nobles y de fácil entretenimiento.

  7. A casa assombrada: considerações sobre o especular e o escópico

    Directory of Open Access Journals (Sweden)

    Andrea Menezes Masagão

    2010-03-01

    Full Text Available A casa é um espaço privilegiado para abordar a identidade, visto que remete à origem e ao reconhecimento. No entanto, nem sempre o ser está em uma relação de adequação a seu habitat. Edgar Allan Poe trabalha o jogo dialético entre o familiar e o estranho de uma forma magistral em seu conto “A queda da casa de Usher”. A dialética do espaço da casa permite abordar o lugar especular do eu, bem como o lugar de ausência do sujeito para além da imagem do espelho. É na queda do suporte especular que surge a dimensão assustadora do olhar.

  8. La casa Bermúdez-Samper, 1952-1960 Bogotá, Colombia

    Directory of Open Access Journals (Sweden)

    María Cecilia O’Byrne Orozco

    2010-12-01

    Full Text Available La casa Bermúdez, proyectada por Guillermo Bermúdez Umaña entre 1952 y 1960, es uno de los proyectos más conocidos y publicados de la arquitectura que se hizo en Bogotá durante la fecunda década de los años cincuenta del siglo XX. Este artículo propone una descripción de la casa a través de los documentos publicados con miras a entender y hacer explícito, desde los elementos, las partes y las relaciones que forman la arquitectura de la casa, el porqué de su fama.

  9. A comparison of several computational auditory scene analysis (CASA) techniques for monaural speech segregation.

    Science.gov (United States)

    Zeremdini, Jihen; Ben Messaoud, Mohamed Anouar; Bouzid, Aicha

    2015-09-01

    Humans have the ability to easily separate a composed speech and to form perceptual representations of the constituent sources in an acoustic mixture thanks to their ears. Until recently, researchers attempt to build computer models of high-level functions of the auditory system. The problem of the composed speech segregation is still a very challenging problem for these researchers. In our case, we are interested in approaches that are addressed to the monaural speech segregation. For this purpose, we study in this paper the computational auditory scene analysis (CASA) to segregate speech from monaural mixtures. CASA is the reproduction of the source organization achieved by listeners. It is based on two main stages: segmentation and grouping. In this work, we have presented, and compared several studies that have used CASA for speech separation and recognition.

  10. Different computer-assisted sperm analysis (CASA) systems highly influence sperm motility parameters.

    Science.gov (United States)

    Boryshpolets, S; Kowalski, R K; Dietrich, G J; Dzyuba, B; Ciereszko, A

    2013-10-15

    In this study, we examined different computer-assisted sperm analysis (CASA) systems (CRISMAS, Hobson Sperm Tracker, and Image J CASA) on the exact same video recordings to evaluate the differences in sperm motility parameters related to the specific CASA used. To cover a wide range of sperm motility parameters, we chose 12-second video recordings at 25 and 50 Hz frame rates after sperm motility activation using three taxonomically distinct fish species (sterlet: Acipenser ruthenus L.; common carp: Cyprinus carpio L.; and rainbow trout: Oncorhynchus mykiss Walbaum) that are characterized by essential differences in sperm behavior during motility. Systematically higher values of velocity and beat cross frequency (BCF) were observed in video recordings obtained at 50 Hz frame frequency compared with 25 Hz for all three systems. Motility parameters were affected by the CASA and species used for analyses. Image J and CRISMAS calculated higher curvilinear velocity (VCL) values for rainbow trout and common carp at 25 Hz frequency compared with the Hobson Sperm Tracker, whereas at 50 Hz, a significant difference was observed only for rainbow trout sperm recordings. No significant difference was observed between the CASA systems for sterlet sperm motility at 25 and 50 Hz. Additional analysis of 1-second segments taken at three time points (1, 6, and 12 seconds of the recording) revealed a dramatic decrease in common carp and rainbow trout sperm speed. The motility parameters of sterlet spermatozoa did not change significantly during the 12-second motility period and should be considered as a suitable model for longer motility analyses. Our results indicated that the CASA used can affect motility results even when the same motility recordings are used. These results could be critically altered by the recording quality, time of analysis, and frame rate of camera, and could result in erroneous conclusions. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. SENTIDOS DE DESACOLHIMENTO DE MÃES SOCIAIS DOS SISTEMAS DE CASAS LARES

    OpenAIRE

    Teixeira, Paulo André Sousa; Villachan-Lyra, Pompéia

    2015-01-01

    A institucionalização de crianças brasileiras é um fenômeno histórico. A presente pesquisa teve por objetivo problematizar os sentidos produzidos pelas mães sociais de uma casa de acolhimento no que diz respeito ao desligamento das crianças em situação de acolhimento prolongado, sendo realizada em uma ONG que trabalha com o sistema "Casa Lar". A coleta de dados foi efetuada a partir de um grupo focal, com o uso de um roteiro de entrevista semiestruturado. Os dados foram interpretados com base...

  12. Los procedimientos contables de Casa Boris: especial referencia al libro mayor (1872-1886)

    OpenAIRE

    José Paulo Cosenza; Carlos Antonio De Rocchi; Carlos Alberto Campello Ribeiro

    2014-01-01

    Boris Frères & Ltd. Co. (conocida popularmente como Casa Boris, denominación que se utiliza en este trabajo), durante ciento doce años tuvo un papel destacado en la economía de Ceará, una Provincia situada al Nordeste de Brasil. Este artículo examina los registros contables realizados en el Libro Mayor de la Casa Boris entre 1872 y 1886. El objetivo de este estudio es el de dar a conocer los hechos observados en el análisis del contenido de sus registros contables, con el fin de describir las...

  13. A Casa do Fim: um conto de José Riço Direitinho

    OpenAIRE

    Oliveira, Catarina Alexandra Monteiro de

    2003-01-01

    The book A Casa do Fim by young writer José Riço Direitinho is made up of ten short and independent stories, stories of life and, above all, of death, played by unusual characters. The writer shapes a strongly rural fictional universe, where he mingles what is real and what is fantastic. A Casa do Fim is a structurally and semantically fractured story, where deep wisdom and ancestral habits are passed on from mother to daughter. The son atones for the sins of the father, and suicide is sho...

  14. CASAS Competencies: Essential Life and Work Skills for Youth and Adults

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2008

    2008-01-01

    The CASAS Competencies identify more than 360 essential life skills that youth and adults need to be functionally competent members of their community, their family, and the workforce. Competencies are relevant across the full range of instructional levels, from beginning literacy through high school completion including transition to…

  15. Guidelines for Providing Accommodations Using CASAS Assessment for Learners with Disabilities

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2005

    2005-01-01

    These guidelines address methods for administering Comprehensive Adult Student Assessment System (CASAS) assessments using accommodations for learners with documented disabilities. The suggested accommodations for disability categories include provisions for: (1) Accommodations in test administration procedures; and (2) Use of appropriate CASAS…

  16. LA CIUDAD DESDE LA CASA: CIUDADES ESPONTÁNEAS EN LIMA

    Directory of Open Access Journals (Sweden)

    José García Calderón

    2010-01-01

    Full Text Available Los asentamientos informales en Lima surgen de la colocación de casas de estera en el desierto, en condiciones de precariedad y pobreza. Sin embargo, en estas siete décadas de existencia se han transformado en barrios relativamente integrados a la ciudad y con un considerable nivel de desarrollo. En esta investigación se describe cómo se ha generado un tejido urbano donde los procesos habituales de planificación, de la gran escala a la pequeña, de la ciudad a la casa (urbanización-parcelación-edificación se ven invertidos encontrando, en esta inversión, el mecanismo clave de su desarrollo. La casa de estera, en origen el único material para asentarse en el territorio, se convierte, más allá de un techo para sus ocupantes, en una estrategia para crear ciudad. La vivienda es taller o tienda, aportando esos usos al tejido urbano; cambia de funciones según las necesidades de los habitantes; crece a medida que se densifica el barrio, muta su tipología (de unifamiliar a colectiva o de carácter (de rural a urbana cuando el asentamiento pasa de pueblo a barrio. La casa crece al tiempo que crece la ciudad que forma; ambos se transforman mutuamente y esta simbiosis confiere al tejido su dinamismo y capacidad para evolucionar.

  17. La Casa de Té como paradigma de la arquitectura en el espacio próximo

    Directory of Open Access Journals (Sweden)

    María Dolores Palacios

    2015-05-01

    Full Text Available La casa de Té es un ejemplo de arquitectura creada para ser percibida por la totalidad de los sentidos. Su ámbito es el espacio próximo, donde la totalidad de las cosas se encuentran al alcance de la mano. Nos habla del hombre y de la naturaleza y de la relación entre ambos.

  18. [History of the locations of the Casa de Orates (madhouse) in Santiago, Chile].

    Science.gov (United States)

    Osorio A, Carlos G

    2016-03-01

    This work describes the origin of the different locations that Casa de Orates (Madhouse) has occupied in Chile. The locations of this institution at the Yungay and Chimba neighborhoods area are specially analyzed. Moreover, the sad and poorly known incident involving the national Madhouse of Providencia is narrated.

  19. Differences in CASA output according to the chamber type when analyzing frozen-thawed bull sperm.

    Science.gov (United States)

    Ibănescu, Iulian; Leiding, Claus; Ciornei, Ştefan Gregore; Roșca, Petru; Sfartz, Ioana; Drugociu, Dan

    2016-03-01

    As demonstrated by some authors, the type of analyzing chamber can greatly influence the results of computer-assisted sperm analysis (CASA). This study aimed to compare three of the disposable chamber types currently available on the market and to determine whether the CASA output may be significantly different among them. The semen from five Fleckvieh bulls was analyzed by CASA using three different disposable chambers: Leja (20μm), MofA (20μm) and Minitube (20μm), at three different time points: immediately after filling the chamber, at 6min, and also at 12min after filling. Sperm concentration was also determined using the Nucleocounter® NC-100™ device and the hemocytometer as standard methods. The results showed higher values in terms of total and progressive sperm motility for MofA compared to the other two chambers immediately after filling (pCASA only when the other methods are not available. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Peer Assessment and Compliance Review (PACR) Innovative Strategies Report. California Court Appointed Special Advocates (CASA) Programs

    Science.gov (United States)

    Macro, Bronwen; Huang, Lee Ann

    2005-01-01

    This report focuses on the innovative strategies study component of the Peer Assessment and Compliance Review (PACR) project. California (Court Appointed Special Advocates) CASA programs have developed many innovative strategies to serve children in their communities. At each of the programs visited during the PACR project, the team identified at…

  1. MONTHLY VARIATION IN SPERM MOTILITY IN COMMON CARP ASSESSED USING COMPUTER-ASSISTED SPERM ANALYSIS (CASA)

    Science.gov (United States)

    Sperm motility variables from the milt of the common carp Cyprinus carpio were assessed using a computer-assisted sperm analysis (CASA) system across several months (March-August 1992) known to encompass the natural spawning period. Two-year-old pond-raised males obtained each mo...

  2. The Cinematic Genesis of the Mel Casas Humanscape, 1965-1967

    Science.gov (United States)

    Cordova, Ruben C.

    2011-01-01

    The 153 paintings that San Antonio-based artist Mel Casas calls Humanscapes were inspired by a glimpse of a drive-in movie screen. This article treats the first three years of work on this series, a period in which the artist referenced cinematic settings and audiences while registering aspects of the sexual revolution. Marshall McLuhan's…

  3. Geologic quadrangle maps of the United States: geology of the Casa Diablo Mountain quadrangle, California

    Science.gov (United States)

    Rinehart, C. Dean; Ross, Donald Clarence

    1957-01-01

    The Casa Diablo Mountain quadrangle was mapped in the summers of 1952 and 1953 by the U.S. Geological Survey in cooperation with the California State Division of Mines as part of a study of potential tungsten-bearing areas.

  4. Influence of counting chamber type on CASA outcomes of equine semen analysis.

    Science.gov (United States)

    Hoogewijs, M K; de Vliegher, S P; Govaere, J L; de Schauwer, C; de Kruif, A; van Soom, A

    2012-09-01

    Sperm motility is considered to be one of the key features of semen analysis. Assessment of motility is frequently performed using computer-assisted sperm analysis (CASA). Nevertheless, no uniform standards are present to analyse a semen sample using CASA. We hypothesised that the type of counting chamber used might influence the results of analysis and aimed to study the effect of chamber type on estimated concentration and motility of an equine semen sample assessed using CASA. Commonly used disposable Leja chambers of different depths were compared with disposable and reusable ISAS chambers, a Makler chamber and a World Health Organization (WHO) motility slide. Motility parameters and concentrations obtained with CASA using these different chambers were analysed. The NucleoCounter was used as gold standard for determining concentration. Concentration and motility parameters were significantly influenced by the chamber type used. Using the NucleoCounter as the gold standard for determining concentration, the correlation coefficients were low for all of the various chambers evaluated, with the exception of the 12 µm deep Leja chamber. Filling a chamber by capillary forces resulted in a lower observed concentration and reduced motility parameters. All chambers evaluated in this study resulted in significant lower progressive motility than the WHO prepared slide, with the exception of the Makler chamber, which resulted in a slight, but statistically significant, increase in progressive motility estimates. Computer-assisted sperm analysis can only provide a rough estimate of sperm concentration and overestimation is likely when drop-filled slides with a coverslip are used. Motility estimates using CASA are highly influenced by the counting chamber; therefore, a complete description of the chamber type used should be provided in semen reports and in scientific articles. © 2011 EVJ Ltd.

  5. Use of multivariate statistics to identify unreliable data obtained using CASA.

    Science.gov (United States)

    Martínez, Luis Becerril; Crispín, Rubén Huerta; Mendoza, Maximino Méndez; Gallegos, Oswaldo Hernández; Martínez, Andrés Aragón

    2013-06-01

    In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was performed. Sixteen boar semen samples were aliquoted then incubated with varying concentrations of progesterone from 0 to 3.33 µg/ml and analyzed in a CASA system. After standardization of the data, Chernoff faces were pictured for each measurement, and a principal component analysis (PCA) was used to reduce the dimensionality and pre-process the data before hierarchical clustering. The first twelve individual measurements showed abnormal features when Chernoff faces were drawn. PCA revealed that principal components 1 and 2 explained 63.08% of the variance in the dataset. Values of principal components for each individual measurement of semen samples were mapped to identify differences among treatment or among boars. Twelve individual measurements presented low values of principal component 1. Confidence ellipses on the map of principal components showed no statistically significant effects for treatment or boar. Hierarchical clustering realized on two first principal components produced three clusters. Cluster 1 contained evaluations of the two first samples in each treatment, each one of a different boar. With the exception of one individual measurement, all other measurements in cluster 1 were the same as observed in abnormal Chernoff faces. Unreliable data in cluster 1 are probably related to the operator inexperience with a CASA system. These findings could be used to objectively evaluate the skill level of an operator of a CASA system. This may be particularly useful in the quality control of semen analysis using CASA systems.

  6. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

    Science.gov (United States)

    Hochstrasser, Megan L; Taylor, David W; Bhat, Prashant; Guegler, Chantal K; Sternberg, Samuel H; Nogales, Eva; Doudna, Jennifer A

    2014-05-06

    In bacteria, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) DNA-targeting complex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bind complementary DNA targets at sites adjacent to a trinucleotide signature sequence called the protospacer adjacent motif (PAM). The Cascade complex then recruits Cas3, a nuclease-helicase that catalyzes unwinding and cleavage of foreign double-stranded DNA (dsDNA) bearing a sequence matching that of the crRNA. Cascade comprises the CasA-E proteins and one crRNA, forming a structure that binds and unwinds dsDNA to form an R loop in which the target strand of the DNA base pairs with the 32-nt RNA guide sequence. Single-particle electron microscopy reconstructions of dsDNA-bound Cascade with and without Cas3 reveal that Cascade positions the PAM-proximal end of the DNA duplex at the CasA subunit and near the site of Cas3 association. The finding that the DNA target and Cas3 colocalize with CasA implicates this subunit in a key target-validation step during DNA interference. We show biochemically that base pairing of the PAM region is unnecessary for target binding but critical for Cas3-mediated degradation. In addition, the L1 loop of CasA, previously implicated in PAM recognition, is essential for Cas3 activation following target binding by Cascade. Together, these data show that the CasA subunit of Cascade functions as an essential partner of Cas3 by recognizing DNA target sites and positioning Cas3 adjacent to the PAM to ensure cleavage.

  7. Additional value of computer assisted semen analysis (CASA) compared to conventional motility assessments in pig artificial insemination.

    Science.gov (United States)

    Broekhuijse, M L W J; Soštarić, E; Feitsma, H; Gadella, B M

    2011-11-01

    In order to obtain a more standardised semen motility evaluation, Varkens KI Nederland has introduced a computer assisted semen analysis (CASA) system in all their pig AI laboratories. The repeatability of CASA was enhanced by standardising for: 1) an optimal sample temperature (39 °C); 2) an optimal dilution factor; 3) optimal mixing of semen and dilution buffer by using mechanical mixing; 4) the slide chamber depth, and together with the previous points; 5) the optimal training of technicians working with the CASA system; and 6) the use of a standard operating procedure (SOP). Once laboratory technicians were trained in using this SOP, they achieved a coefficient of variation of CASA. CASA results are preferable as accurate continuous motility dates are generated rather than discrimination motility percentage increments of 10% motility as with motility estimation by laboratory technicians. The higher variability of sperm motility found with CASA and the continuous motility values allow better analysis of the relationship between semen motility characteristics and fertilising capacity. The benefits of standardised CASA for AI is discussed both with respect to estimate the correct dilution factor of the ejaculate for the production of artificial insemination (AI) doses (critical for reducing the number of sperm per AI doses) and thus to get more reliable fertility data from these AI doses in return. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Reacción constitucional producida por el extracto de polvo de casa

    Directory of Open Access Journals (Sweden)

    Enrique Drassinower H.

    1951-01-01

    Full Text Available 1° Hemos hecho una exposición general del polvo de casa, señalando que pertenece al grupo de los alergenos inhalantes no estacionales y hemos precisado que en nuestro medio es el alergeno inhalante más importante y el responsable más frecuente de las afecciones alérgicas del aparato respiratorio. 2° Hemos expuesto su composición, remarcando que su acción antigénica no depende de los alergenos inhalantes que entran como sus componentes, sino de un factor específico de alto poder antigénico, cuya naturaleza aún no ha podido ser precisada. 3° Somos partidarios de que el polvo de casa efectivamente posee acción antigénica y de que esta acción es debida a un factor específico. 4° Mencionamos que a favor de estos dos principios existen numerosas pruebas (entre las que destaca la de PRAUSNITZ-KÜSTNER o de la transmisión pasiva que demuestra la existencia de anticuerpos circulantes específicos, pero nos limitamos a señalar sobre todo los hechos de observación personal: Los benéficos efectos clínicos que hemos obtenido en nuestro medio con la desensibilización practicada tanto con extractos de polvo de casa autógenos como con extractos stock o mixtos. El estudio comparativo que hemos efectuado, tanto desde el punto de vista del diagnóstico como del tratamiento desensibilizante, entre los extractos de polvo de casa de la ciudad de Nueva York y los extractos de polvo de casa autógenos y stock de nuestro medio, nos ha permitido observar resultados sensiblemente iguales, lo que sin duda habla a favor de que la acción antigénica del polvo de casa es debida a un factor específico, el cual estaría presente en los tres extractos. Expusimos por último, que otra prueba concluyente a favor de la acción antigénica del polvo de casa lo constituye la reacción constitucional producida por el extracto de éste, y remarcamos lo infrecuente de estas reacciones con el extracto de polvo de casa. 5° Relatamos dos casos clínicos de

  9. Definición de un CRM para Casa Guatemala. Selección y adaptación de un CRM OpenSource para Casa Guatemala.

    OpenAIRE

    Iglesias Iglesias, Alberto

    2011-01-01

    El objetivo general de este proyecto es ayudar a las personas encargadas de dirigir y gestionar la institución, usando un sistema experto que, una vez alimentado con los datos necesarios, sea capaz de prever crisis económicas dentro de la institución, la calidad de vida de los niños, ayudar a gestionar el personal, tanto voluntariado como trabajadores, etc. En definitiva, ayudar y conseguir en la medida de lo posible la autosuficiencia de Casa Guatemala para tener un nivel d...

  10. Influence of chamber type integrated with computer-assisted semen analysis (CASA) system on the results of boar semen evaluation.

    Science.gov (United States)

    Gączarzewicz, D

    2015-01-01

    The objective of the study was to evaluate the effect of different types of chambers used in computer-assisted semen analysis (CASA) on boar sperm concentration and motility parameters. CASA measurements were performed on 45 ejaculates by comparing three commonly used chambers: Leja chamber (LJ), Makler chamber (MK) and microscopic slide-coverslip (SL). Concentration results obtained with CASA were verified by manual counting on a Bürker hemocytometer (BH). No significant differences were found between the concentrations determined with BH vs. LJ and SL, whereas higher (p0.05). The results obtained show that CASA assessment of boar semen should account for the effect of counting chamber on the results of sperm motility and concentration, which confirms the need for further study on standardizing the automatic analysis of boar semen.

  11. Projeto de extensão “lendo e escrevendo na casa lar”

    OpenAIRE

    Terezinha Corrêa Lindino; Rita Maria Decarli Bottega; Verônica Pereira Coutinho Constanty; Alessandra Venâncio Justino; Aline Luane Fantinel; Amanda Perin Nonose; Andréia Carla Bach Kunzler; Francine Raquel Hoff Zibetti Zimmermann; Kelly Yara Hedel; Leomir Bruch; Patrícia Helena Frai; Sônia Regina Pinheiro Corrêa; Thiago Rafael Mazzarollo; Vanessa Borella da Ross

    2014-01-01

    http://dx.doi.org/10.5007/1807-0221.2013v10n16p1 O Projeto “Lendo e Escrevendo na Casa Lar”, edição 2012, teve como objetivo desenvolver atividades de leitura, escrita e alfabetização com crianças usuárias da Casa Lar da cidade de Marechal Cândido Rondon. Elaborado pela equipe pedagógica do Núcleo de Estudos e Defesa dos Direitos da Infância e da Juventude (NEDDIJ), em parceria com o Grupo de Estudo e Pesquisa em Formação de Professores (GEPEFOP), o Núcleo de Formação Docente e Prática de...

  12. Bartolomé de las Casas y Michel de Montaigne: Escritura y lectura del Nuevo Mundo

    Directory of Open Access Journals (Sweden)

    Juan Durán Luzio

    2016-04-01

    Full Text Available Se trata de mostrar cómo la obra de Bartolomé de Las Casas, Brevísima relación de la destrucción de las Indias, publicada en 1552 y traducida al francés en 1579,fue leída por Michel de Montaigne e incorporada en sus párrafos y doctrinas más relevantes en sus dos ensayos sobre el Nuevo Mundo: "Des Cannibales" (1580 y "Des Coches" (1588.   The work of Bartolomé de Las Casas Brevísima relación de la destrucción de las Indias, published in 1552 and translated into French in 1579, is shown to have been read by Michel de Montaigne who included it in the most relevant paragraphs and doctrines in his two essays about the new world: "Des Cannibales" (1850 and "Des Coches" (1588.

  13. Bartolomé de las Casas y Michel de Montaigne: Escritura y lectura del Nuevo Mundo

    OpenAIRE

    Juan Durán Luzio

    2016-01-01

    Se trata de mostrar cómo la obra de Bartolomé de Las Casas, Brevísima relación de la destrucción de las Indias, publicada en 1552 y traducida al francés en 1579,fue leída por Michel de Montaigne e incorporada en sus párrafos y doctrinas más relevantes en sus dos ensayos sobre el Nuevo Mundo: "Des Cannibales" (1580) y "Des Coches" (1588).   The work of Bartolomé de Las Casas Brevísima relación de la destrucción de las Indias, published in 1552 and translated into French in 1579, is sho...

  14. Relatório de Estágio em La Casa Amarilla (Barcelona)

    OpenAIRE

    Serrazina, Catarina Lopes

    2013-01-01

    Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Práticas Culturais para Municípios Este relatório procura apresentar os resultados das 570 horas de estágio em La Casa Amarilla e lançar uma base de reflexão acerca da pertinência que entidades como aquela que acolheu o estágio possuem nas cidades que as albergam. La Casa Amarilla é uma associação cultural sem fins lucrativos, com estatuto de organização não governamental, sediada e...

  15. Antropologia visuale dei senza casa di Place de la Réunion

    Directory of Open Access Journals (Sweden)

    Sylvaine Conord

    2008-07-01

    Full Text Available Questo quartiere negli anni 90 veniva considerato una zona prevalentemente popolare. Oggi resta l’esempio emblematico di una Parigi popolare in mutamento. Questa ricerca è sempre attuale grazie al soggetto: i senza casa. La questione dei senza casa nella regione parigina non è risolta: migliaia di nuclei familiari attendono l'assegnazione di un alloggio abitabile. Numerose famiglie vivono in palazzi occupati, nonostante abbiano presentato presso i servizi pubblici la loro domanda da molti anni. Quindi, oltre ad un osservazione partecipante, questo lavoro pone l’accento "su una sociologia militante" che prende corpo attraverso le testimonianze e la partecipazione attiva dell'osservatrice alle diverse situazioni che vive e vede.

  16. Some tests of wet tropospheric calibration for the CASA Uno Global Positioning System experiment

    Science.gov (United States)

    Dixon, T. H.; Wolf, S. Kornreich

    1990-01-01

    Wet tropospheric path delay can be a major error source for Global Positioning System (GPS) geodetic experiments. Strategies for minimizing this error are investigted using data from CASA Uno, the first major GPS experiment in Central and South America, where wet path delays may be both high and variable. Wet path delay calibration using water vapor radiometers (WVRs) and residual delay estimation is compared with strategies where the entire wet path delay is estimated stochastically without prior calibration, using data from a 270-km test baseline in Costa Rica. Both approaches yield centimeter-level baseline repeatability and similar tropospheric estimates, suggesting that WVR calibration is not critical for obtaining high precision results with GPS in the CASA region.

  17. O mito do gaúcho em A casa das sete mulheres

    Directory of Open Access Journals (Sweden)

    Menger, Amanda da Silva

    2011-01-01

    Full Text Available O presente artigo, O mito do gaúcho em A Casa das Sete Mulheres, trata do mito do gaúcho. Aborda desde o seu conceito, a sua formação até a perpetuação. Para isso, o trabalho faz uma retomada histórica do gaúcho, entre o pária e o herói e a influência da História e das Tecnologias do Imaginário, teoria proposta por Juremir Machado da Silva (2003, para esta mudança. O artigo também trata da imagem do gaúcho apresentada pela minissérie A Casa das Sete Mulheres

  18. SOBRE LA TRADUCCIÓN DEL POEMA DE GABRIEL ARESTI "LA CASA DE MI PADRE"

    Directory of Open Access Journals (Sweden)

    Vladimer Luarsabishvili

    2014-10-01

    Full Text Available En este artículo se analizan varias versiones del poema de Gabriel Aresti «La casa de mi padre». El autor profundiza en la teoría y práctica de la traducción con el ejemplo de varios traductores. En el artículo se citan ejemplos concretos de diversas traducciones de  K. Gamsakhurdia, M. Tsvetaeva, V. Nabokov, J. Borges etc. Al término de su trabajo el autor propone su propia versión de traducción al ruso del poema de Gabriel Aresti «La casa de mi padre».

  19. Chimenea and other tools: Automated imaging of multi-epoch radio-synthesis data with CASA

    Science.gov (United States)

    Staley, T. D.; Anderson, G. E.

    2015-11-01

    In preparing the way for the Square Kilometre Array and its pathfinders, there is a pressing need to begin probing the transient sky in a fully robotic fashion using the current generation of radio telescopes. Effective exploitation of such surveys requires a largely automated data-reduction process. This paper introduces an end-to-end automated reduction pipeline, AMIsurvey, used for calibrating and imaging data from the Arcminute Microkelvin Imager Large Array. AMIsurvey makes use of several component libraries which have been packaged separately for open-source release. The most scientifically significant of these is chimenea, which implements a telescope-agnostic algorithm for automated imaging of pre-calibrated multi-epoch radio-synthesis data, of the sort typically acquired for transient surveys or follow-up. The algorithm aims to improve upon standard imaging pipelines by utilizing iterative RMS-estimation and automated source-detection to avoid so called 'Clean-bias', and makes use of CASA subroutines for the underlying image-synthesis operations. At a lower level, AMIsurvey relies upon two libraries, drive-ami and drive-casa, built to allow use of mature radio-astronomy software packages from within Python scripts. While targeted at automated imaging, the drive-casa interface can also be used to automate interaction with any of the CASA subroutines from a generic Python process. Additionally, these packages may be of wider technical interest beyond radio-astronomy, since they demonstrate use of the Python library pexpect to emulate terminal interaction with an external process. This approach allows for rapid development of a Python interface to any legacy or externally-maintained pipeline which accepts command-line input, without requiring alterations to the original code.

  20. THE ROLE OF EMPLOYEE PERFORMANCE APPRAISAL AT CASA DE LA ROSA TIMISOARA

    Directory of Open Access Journals (Sweden)

    SILVIA VLAD

    2015-04-01

    Full Text Available The purpose of this research is to analyze the most important aspects of employee performance appraisal role in a hotel. The research is based on highlighting the major aspects of employee performance appraisal at Casa de la Rosa Hotel and aims the aspects related to the hotel performance. The aim of this evaluation is to observe and to analyze the employee time evolution and the way they complete their tasks and their job requirements.

  1. Radar search and detection with the CASA 212 S43 aircraft

    OpenAIRE

    Landa Borges, José Manuel

    2004-01-01

    Approved for public release; distribution in unlimited. This research develops a detection rate model to analyze the effectiveness of the RDR 1500B search radar installed in the CASA 212 S43 aircraft belonging to Venezuelan Naval Aviation. The model is based on a search and detection mission to find a diesel submarine executing an incursion inside the Venezuelan Caribbean Sea area, assumed to be intermittently operating with periscopes or masts exposed above the sea surface. The analysis o...

  2. Casa Santos Lima : from “Business as Usual” to “Expand”

    OpenAIRE

    Sabido, João Oliveira da Silva

    2016-01-01

    The case study aims to evaluate the strategy formulation of Casa Santos Lima (CSL), a Portuguese wine company, whose profile and competitive business were very useful to discuss and recommend overall strategic priorities that should guide CLS’s development and overcome with success rather challenging times ahead. From a traditional wine farm located in Alenquer, in the denominated wine producer area of Lisbon, CSL implemented a philosophy of management based on high quality ...

  3. Los procedimientos contables de Casa Boris: especial referencia al libro mayor (1872-1886

    Directory of Open Access Journals (Sweden)

    José Paulo Cosenza

    2014-12-01

    Full Text Available Boris Frères & Ltd. Co. (conocida popularmente como Casa Boris, denominación que se utiliza en este trabajo, durante ciento doce años tuvo un papel destacado en la economía de Ceará, una Provincia situada al Nordeste de Brasil. Este artículo examina los registros contables realizados en el Libro Mayor de la Casa Boris entre 1872 y 1886. El objetivo de este estudio es el de dar a conocer los hechos observados en el análisis del contenido de sus registros contables, con el fin de describir las prácticas contables utilizadas por esta empresa de comercio en la conducción de sus negocios. Además, quisimos identificar los aspectos contables considerados relevantes y de interés para la historia de la contabilidad brasileña que explican la realización de las actividades mercantes desarrolladas por la Casa Boris en la Provincia de Ceará y en las ciudades vecinas. Los resultados del estudio ponen de manifiesto que los registros contables de la Casa Boris son transparentes, a punto de evidenciar y ayudar a explicar las transacciones económicas realizadas por dicha empresa según el marco comercial de la época y también, para poner de manifiesto el contexto histórico de la contabilidad durante la segunda monarquía brasileña, además de mostrar la coexistencia de un mercado provincial incipiente basado en una red de comercio uniendo Brasil y Europa.

  4. Usefulness of hemocytometer as a counting chamber in a computer assisted sperm analyzer (CASA)

    Science.gov (United States)

    Eljarah, A.; Chandler, J.; Jenkins, J.A.; Chenevert, J.; Alcanal, A.

    2013-01-01

    Several methods are used to determine sperm cell concentration, such as the haemocytometer, spectrophotometer, electronic cell counter and computer-assisted semen analysers (CASA). The utility of CASA systems has been limited due to the lack of characterization of individual systems and the absence of standardization among laboratories. The aims of this study were to: 1) validate and establish setup conditions for the CASA system utilizing the haemocytometer as a counting chamber, and 2) compare the different methods used for the determination of sperm cell concentration in bull semen. Two ejaculates were collected and the sperm cell concentration was determined using spectrophotometer and haemocytometer. For the Hamilton-Thorn method, the haemocytometer was used as a counting chamber. Sperm concentration was determined three times per ejaculate samples. A difference (P 0.05) or between the haemocytometer count and the spectrophotometer. Based on the results of this study, we concluded that the haemocytometer can be used in computerized semen analysis systems as a substitute for the commercially available disposable counting chambers, therefore avoiding disadvantageous high costs and slower procedures.

  5. Sperm motility in fish: technical applications and perspectives through CASA-Mot systems.

    Science.gov (United States)

    Gallego, V; Asturiano, J F

    2018-03-09

    Although a relatively high number of sperm quality biomarkers have been reported over the years in several fish species, sperm motility is nowadays considered the best biomarker for fish spermatozoa. The first scientific reports focusing on fish sperm motility date from a century ago, but the objective assessment allowed by computer-aided sperm analysis (CASA-Mot) systems was not applied to fish species until the mid-1980s. Since then, a high number of sperm kinetic parameters from more than 170 fish species have been reported in more than 700 scientific articles, covering a wide range of topics, such as sperm physiology, sperm storage, broodstock management, the phenomenon of sperm competition, ecotoxicology and understanding the life cycle of the species. The sperm kinetic parameters provided by CASA-Mot systems can serve as powerful and useful tools for aquaculture and ecological purposes, and this review provides an overview of the major research areas in which fish sperm motility assessment by a CASA-Mot system has been used successfully.

  6. Selective degradation of the recalcitrant cell wall of Scenedesmus quadricauda CASA CC202.

    Science.gov (United States)

    Reshma, Ragini; Arumugam, Muthu

    2017-10-01

    An eco-friendly cell wall digestion strategy was developed to enhance the availability of nutritionally important bio molecules of edible microalgae and exploit them for cloning, transformation, and expression of therapeutic proteins. Microalgae are the source for many nutritionally important bioactive compounds and potential drugs. Even though edible microalgae are rich in nutraceutical, bioavailability of all these molecules is very less due to their rigid recalcitrant cell wall. For example, the cell wall of Scenedesmus quadricauda CASA CC202 is made up of three layers comprising of rigid outer pectin and inner cellulosic layer separated by a thin middle layer. In the present investigation, a comprehensive method has been developed for the selective degradation of S. quadricauda CASA CC202 cell wall, by employing both mechanical and enzymatic treatments. The efficiency of cell wall removal was evaluated by measuring total reducing sugar (TRS), tannic acid-ferric chloride staining, calcoflour white staining, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) analysis. It was confirmed that the yield of TRS increased from 129.82 mg/g in 14 h from pectinase treatment alone to 352.44 mg/g by combined sonication and enzymatic treatment within 12 h. As a result, the combination method was found to be effective for the selective degradation of S. quadricauda CASA CC202 cell wall. This study will form a base for our future works, where this will help to enhance the digestibility and availability of nutraceutically important proteins.

  7. Evaluation of sperm motility with CASA-Mot: which factors may influence our measurements?

    Science.gov (United States)

    Yeste, Marc; Bonet, Sergi; Rodríguez-Gil, Joan E; Rivera Del Álamo, Maria M

    2018-03-14

    Computer-aided sperm analysis (CASA) is now routinely used in IVF clinics, animal breeding centres and research laboratories. Although CASA provides a more objective way to evaluate sperm parameters, a significant number of factors can affect these measurements. This paper classifies these factors into four categories: (1) sample and slide (e.g. preincubation time, type of specimen and type of chamber slide); (2) microscope (e.g. light source and microscope stage); (3) hardware and software, including the settings of each system; and (4) user-related factors. We review the effects of the different factors in each category on the measurements made and emphasise the need to take measures to standardise evaluations. The take-home message of the present article is that there are several commercial and useful CASA systems, and all are appropriate for routine analysis. Non-commercial systems may also be good choices when the user needs to adapt the device to specific experimental conditions. In both cases (commercial and non-commercial), it is important that standard protocols are put in place for evaluation, as well as methods to validate the system.

  8. CASA : oil and gas industry perspective : flaring : case study of success

    International Nuclear Information System (INIS)

    Pryce, D.

    2002-01-01

    A brief overview of the Canadian Association of Petroleum Producers (CAPP) and its mission is provided at the beginning of this presentation. The importance of flaring is explained, as it represents a safety precaution in the event of an emergency or process upset. It is also an important part of operations, and is valuable in well test evaluations for gathering information as part of the facility design process. Some of the major issues associated with flaring are reviewed, namely flare performance; concerns related to health risks, odour, visibility, greenhouse gases, resource conservation; the position of the Energy and Utilities Board (EUB), and the need of the industry for regulatory certainty. The Clean Air Strategic Alliance (CASA) was commissioned by the CAPP to examine the issue of flaring in November 1996 as part of the CASA flaring project team. The key recommendations of the CASA flaring team project were submitted in 1998 and included: focus on solution gas at oil batteries, the establishment of a new management framework. The author presents the Alberta provincial policy objective with regard to flaring. The best management practices decision tree is explained, along with management tools, which were incorporated in a new guide for flaring issued in July 1999 by the Alberta Energy and Utilities Board. The reduction targets are reviewed, and the author explains the rationale for the industry support of the recommendations. The progress to date is reviewed, and the next steps in the ongoing process are described, such as the formal progress review currently underway

  9. A vivência do cuidado familiar em casas transitórias de apoio

    Directory of Open Access Journals (Sweden)

    Jaqueline Dias do Nascimento

    2016-06-01

    Full Text Available RESUMO Objetivo: apresentar modelo teórico representativo da vivência do cuidado em casas transitórias de apoio a familiares de crianças em pós-transplante de células-tronco hematopoiéticas. Método: Teoria Fundamentada nos Dados, realizada com 18 participantes de três grupos amostrais. Para análise, utilizou-se o software QSR Nvivo10. Resultados: elaboraram-se quatro categorias: residindo em casa transitória de apoio; vivenciando o cuidado à criança em pós-transplante de células-tronco hematopoiéticas; cuidando do cuidador familiar; e retornando a uma nova vida no lar, as quais se inter-relacionam conforme o código teórico da família interativa. Conclusão: esta pesquisa contribui para compreensão da vivência do cuidado em casas transitórias de apoio a familiares de crianças em pós-transplante de células-tronco hematopoiéticas e subsidia as ações de enfermagem e saúde prestadas a esta população; contribui ainda para a elaboração de orientação de alta hospitalar e cuidado direcionado a essa clientela.

  10. El uso de los presupuestos en la Casa ducal de Osuna (1860-69

    Directory of Open Access Journals (Sweden)

    Jesús Damián López Manjón

    2006-12-01

    El trabajo se basa en la descripción y el análisis de fuentes primarias conservadas en la Sección Nobleza del Archivo Histórico Nacional y en el Archivo Histórico de Protocolos de Madrid. La discusión permite, por un lado, conocer la situación de la Casa ducal a partir del presupuesto de 1862. Por otro lado, se presenta el debate surgido en la organización acerca del empleo de presupuestos, enfrentándose posturas reacias a su uso, intentos de implantarlos como una herramienta para la gestión de la Casa y presiones para que se usaran como limitaciones del gasto. Siendo esta última, la postura que logró imponerse, el debate sobre el uso de los presupuestos en la Casa se produjo en paralelo a la dialéctica política entre liberales y conservadores que caracterizó a la España del siglo XIX y al auge de la burguesía liberal.

  11. Resultados preliminares da pesquisa no sambaqui sob rocha Casa de Pedra, São Francisco do Sul, Santa Catarina, Brasil

    Directory of Open Access Journals (Sweden)

    Dione da Rocha Bandeira

    Full Text Available Resumo A baía da Babitonga possui um patrimônio arqueológico riquíssimo, constituído por um conjunto numeroso de sambaquis, relacionados a pescadores-caçadores-coletores pré-coloniais. O projeto em desenvolvimento volta-se para um sambaqui localizado sob uma gruta no litoral leste de São Francisco do Sul, Santa Catarina, Brasil: o sambaqui sob rocha Casa de Pedra. O sítio apresenta camada arqueológica de 38 cm de espessura e área de 27 m2, e vem sendo escavado desde 2015, com rebaixamento em níveis artificiais de 5 cm de profundidade, em 30 setores de 1 x 1 m. A matriz é composta predominantemente por fragmentos ósseos de ictiofauna e por material conquiológico. Foram encontrados ossos humanos esparsos, alguns queimados, nas primeiras camadas. Osso humano e conchas a 3 cm e 20-25 cm de profundidade apresentaram datação de 4.460 ± 30 e 5.470 ± 30 anos AP, respectivamente. Porém, datações do sedimento da base do sítio apresentaram 4.330 ± 700 e 5.670 ± 850 anos AP, levando-nos a questionar a origem da matriz arqueológica e a sua posição em contexto temporal. Nas paredes internas da gruta, verificaram-se pinturas rupestres, que, após resultados mais concretos, poderão ser o primeiro registro no estado deste tipo de manifestação associada a sambaquis.

  12. Modification of computational auditory scene analysis (CASA) for noise-robust acoustic feature

    Science.gov (United States)

    Kwon, Minseok

    While there have been many attempts to mitigate interferences of background noise, the performance of automatic speech recognition (ASR) still can be deteriorated by various factors with ease. However, normal hearing listeners can accurately perceive sounds of their interests, which is believed to be a result of Auditory Scene Analysis (ASA). As a first attempt, the simulation of the human auditory processing, called computational auditory scene analysis (CASA), was fulfilled through physiological and psychological investigations of ASA. CASA comprised of Zilany-Bruce auditory model, followed by tracking fundamental frequency for voice segmentation and detecting pairs of onset/offset at each characteristic frequency (CF) for unvoiced segmentation. The resulting Time-Frequency (T-F) representation of acoustic stimulation was converted into acoustic feature, gammachirp-tone frequency cepstral coefficients (GFCC). 11 keywords with various environmental conditions are used and the robustness of GFCC was evaluated by spectral distance (SD) and dynamic time warping distance (DTW). In "clean" and "noisy" conditions, the application of CASA generally improved noise robustness of the acoustic feature compared to a conventional method with or without noise suppression using MMSE estimator. The intial study, however, not only showed the noise-type dependency at low SNR, but also called the evaluation methods in question. Some modifications were made to capture better spectral continuity from an acoustic feature matrix, to obtain faster processing speed, and to describe the human auditory system more precisely. The proposed framework includes: 1) multi-scale integration to capture more accurate continuity in feature extraction, 2) contrast enhancement (CE) of each CF by competition with neighboring frequency bands, and 3) auditory model modifications. The model modifications contain the introduction of higher Q factor, middle ear filter more analogous to human auditory system

  13. The comparison of assessment of pigeon semen motility and sperm concentration by conventional methods and the CASA system (HTM IVOS).

    Science.gov (United States)

    Klimowicz, M D; Nizanski, W; Batkowski, F; Savic, M A

    2008-07-01

    The aim of these experiments was to compare conventional, microscopic methods of evaluating pigeon sperm motility and concentration to those measured by computer-assisted sperm analysis (CASA system). Semen was collected twice a week from two groups of pigeons, each of 40 males (group I: meat-type breed; group II: fancy pigeon) using the lumbo-sacral and cloacal region massage method. Ejaculates collected in each group were diluted 1:100 in BPSE solution and divided into two equal samples. One sample was examined subjectively by microscope and the second one was analysed using CASA system. The sperm concentration was measured by CASA using the anti-collision (AC) system and fluorescent staining (IDENT). There were not any significant differences between the methods of evaluation of sperm concentration. High positive correlations in both groups were observed between the sperm concentration estimated by Thom counting chamber and AC (r=0.87 and r=0.91, respectively), and between the sperm concentration evaluated by Thom counting chamber and IDENT (r=0.85 and r=0.90, respectively). The mean values for CASA measurement of proportion of motile spermatozoa (MOT) and progressive movement (PMOT) were significantly lower than the values estimated subjectively in both groups of pigeons (pCASA system is very rapid, objective and sensitive method in detecting subtle motility characteristics as well as sperm concentration and is recommended for future research into pigeon semen.

  14. Manual vs. computer-assisted sperm analysis: can CASA replace manual assessment of human semen in clinical practice?

    Science.gov (United States)

    Talarczyk-Desole, Joanna; Berger, Anna; Taszarek-Hauke, Grażyna; Hauke, Jan; Pawelczyk, Leszek; Jedrzejczak, Piotr

    2017-01-01

    The aim of the study was to check the quality of computer-assisted sperm analysis (CASA) system in comparison to the reference manual method as well as standardization of the computer-assisted semen assessment. The study was conducted between January and June 2015 at the Andrology Laboratory of the Division of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, Poland. The study group consisted of 230 men who gave sperm samples for the first time in our center as part of an infertility investigation. The samples underwent manual and computer-assisted assessment of concentration, motility and morphology. A total of 184 samples were examined twice: manually, according to the 2010 WHO recommendations, and with CASA, using the program set-tings provided by the manufacturer. Additionally, 46 samples underwent two manual analyses and two computer-assisted analyses. The p-value of p CASA and manually. In the group of patients where all analyses with each method were performed twice on the same sample we found no significant differences between both assessments of the same probe, neither in the samples analyzed manually nor with CASA, although standard deviation was higher in the CASA group. Our results suggest that computer-assisted sperm analysis requires further improvement for a wider application in clinical practice.

  15. Electricity sector standard setting through CASA : a government perspective on multi-stakeholder partnerships

    International Nuclear Information System (INIS)

    Lakeman, B.

    2002-01-01

    Some background information is provided concerning new air emission standards for coal-fired generation in Alberta which were announced in June 2001 by the Environment Minister. An assessment of the situation has revealed that the existing management system is effective. The author questions whether it would be suitable to meet the challenges now emerging, such as multi-pollutant approaches, airshed approaches, cumulative effects, market-based approaches, and greenhouse gases. A Statement of Opportunity was tabled by the Alberta government with the Clean Air Strategic Alliance (CASA) board in November 2001, with the goals of outlining future emission management expectations, maintaining the competitive electricity market in Alberta, and a reduction of environmental impacts, among others. A CASA electricity project team was formed, whose stated objective was the development of an air emissions management approach to include standards and performance expectations for the electricity sector of Alberta. Stakeholders and the public were consulted for the purpose of establishing a common information base to be used in the identification of emissions to be addressed, the identification and assessment of management options and the recommendation of management approaches. The development of the terms of reference was accomplished through the establishment of a working group in January 2002. which were then approved in March 2002 by the CASA board. The budget and work plan were approved in June 2002, and an interim review is planned for November 2002 with the final report and recommendations expected in June 2003. The members of the team were listed, and some of the challenges are reviewed

  16. Arquitecturas reversibles de Japón. Las casas de Shirakawa-go

    Directory of Open Access Journals (Sweden)

    Paula Jaén Caparrós

    2017-04-01

    Full Text Available “Minka” significa literalmente “casas de la gente” en japonés, y se refiere a la casa tradicional japonesa construida fundamentalmente desde las épocas más antiguas hasta finales del siglo XIX. Se trata de construcciones sencillas y ligeras hechas habitualmente con elementos de madera, bambú, y paja, unidos por juntas de madera y cuerdas. Las regiones montañosas de Shirakawa-go y Gokayama, en la zona central de Japón, al Oeste de Tokio, permanecieron aisladas durante un largo periodo de tiempo. Como consecuencia de ello, allí se desarrolló un tipo específico de minka, las llamadas Gassho-zukuri, caracterizadas por el uso de un sistema extremadamente lógico y racional en su construcción resultado de una adaptación natural a las difíciles condiciones del entorno. Construidas como estructuras permanentes, estas casas tradicionales son sin embargo desmontables: sus distintos componentes permiten ser desarmados, recuperados y ensamblados de nuevo sin mayor dificultad. El alto potencial de desmontaje contenido en estas pequeñas construcciones invita a reflexionar acerca de las pautas proyectuales y constructivas presentes en sus soluciones que podrían ser recuperadas y aplicadas en propuestas actuales que integraran el desmontaje, la recuperación y el traslado de todo el objeto construido como factor clave para un diseño arquitectónico sostenible.

  17. Retrospective study of penetrating keratoplasty at the Santa Casa of Porto Alegre

    OpenAIRE

    Fabris, Caroline; Corrêa, Zélia Maria S.; Marcon, Alexandre S.; Castro, Terla Nunes de; Marcon, Ítalo Mundialino; Pawlowski, Cristiane

    2001-01-01

    Objetivos: Traçar o perfil clínico e social dos pacientes submetidos a transplante de córnea e avaliar as principais indicações desses transplantes, tempo de espera para doação e os índices de sucesso, rejeição e falência dos transplantes penetrantes de córnea. Métodos: Foram analisados retrospectivamente os prontuários de 87 pacientes submetidos a transplante penetrante de córnea no Serviço de Oftalmologia da Santa Casa de Porto Alegre entre janeiro de 1990 e dezembro de 1998, totalizando 91...

  18. Projeto de extensão “lendo e escrevendo na casa lar”

    Directory of Open Access Journals (Sweden)

    Terezinha Corrêa Lindino

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/1807-0221.2013v10n16p1 O Projeto “Lendo e Escrevendo na Casa Lar”, edição 2012, teve como objetivo desenvolver atividades de leitura, escrita e alfabetização com crianças usuárias da Casa Lar da cidade de Marechal Cândido Rondon. Elaborado pela equipe pedagógica do Núcleo de Estudos e Defesa dos Direitos da Infância e da Juventude (NEDDIJ, em parceria com o Grupo de Estudo e Pesquisa em Formação de Professores (GEPEFOP, o Núcleo de Formação Docente e Prática de Ensino (NUFOPE e o Programa Institucional de Bolsa de Iniciação à Docência (PIBID, o projeto visou atender ao pedido do Conselho Municipal dos Direitos da Criança e do Adolescente (CMDCA do município de Marechal Cândido Rondon, de modo a minimizar as dificuldades pedagógicas apresentadas pelas crianças atendidas na Casa Lar dessa cidade. Para efetivar seu objetivo, as atividades que compuseram o projeto foram organizadas nas dependências da Casa Lar, conforme horário esquematizado pelos pais sociais, contando com a participação das coordenadoras e dos graduandos envolvidos. Em cada encontro, foram desenvolvidas oficinas sobre coordenação motora, ludicidade, leitura, escrita e aplicação de técnicas de Yoga, que visam auxiliar na aprendizagem e execução das atividades propostas. Para a realização dessas atividades, dividimos o grupo de participantes em três equipes, compostas por monitores dos cursos de Pedagogia, Letras, Geografia e Serviço Social. A cada período, por meio de reuniões entre os monitores e as coordenadoras do projeto, foi realizada uma verificação do andamento e progresso das crianças.

  19. Análisis de Clima Organizacional de Baltimore Spice C.A.S.A.

    OpenAIRE

    Wong Carranza, Henry Paul

    2004-01-01

    Tesis de maestría -- Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas con énfasis en Gerencia, 2004 El objetivo general del trabajo es realizar un diagnóstico de los elementos que inciden e impactan negativamente en el desempeño del clima organizacional de Baltimore Spice C.A.S.A., que se ven reflejados directa e indirectamente en el rendimiento de los colaboradores en el nivel operativo. La organi...

  20. A casa da cabeça de cavalo: a morte como lucidez

    Directory of Open Access Journals (Sweden)

    Maria Theresa Abelha Alves

    2003-03-01

    Full Text Available Oromance de Teolinda Gersão, A casa da cabeça de cavalo, mesclando variados modelos narrativos, tais como o romance de folhetim, a narrativa fantástica e a metaficção historiográfica, propõe uma nova perspectiva para os fatos e os conceitos consagrados pela lógica e adota, como estratégia desconstrutora, o lúdico e o humorístico, ao discursar sobre a morte e sobre a História. 

  1. Vascular Plant and Vertebrate Inventory of Casa Grande Ruins National Monument

    Science.gov (United States)

    Powell, Brian F.; Albrecht, Eric W.; Schmidt, Cecilia A.; Halvorson, William L.; Anning, Pamela; Docherty, Kathleen

    2006-01-01

    Executive Summary This report summarizes results of the first comprehensive biological inventory of Casa Grande Ruins National Monument (NM) in southern Arizona. Surveys at the monument were part of a larger effort to inventory vascular plants and vertebrates in eight National Park Service units in Arizona and New Mexico. In 2001 and 2002 we surveyed for vascular plants and vertebrates (amphibians, reptiles, birds, and mammals) at Casa Grande Ruins NM to document the presence, and in some cases relative abundance, of species. By using repeatable study designs and standardized field techniques, which included quantified survey effort, we produced inventories that can serve as the basis for a biological monitoring program. Of the National Park Service units in the region, no other has experienced as much recent ecological change as Casa Grande Ruins NM. Once situated in a large and biologically diverse mesquite bosque near the perennially flowing Gila River, the monument is now a patch of sparse desert vegetation surrounded by urban and commercial development that is rapidly replacing agriculture as the dominant land use in the area. Roads, highways, and canals surround the monument. Development, and its associated impacts, has important implications for the plants and animals that live in the monument. The plant species list is small and the distribution and number of non-native plants appears to be increasing. Terrestrial vertebrates are also being impacted by the changing landscape, which is increasing the isolation of these populations from nearby natural areas and thereby reducing the number of species at the monument. These observations are alarming and are based on our review of previous studies, our research in the monument, and our knowledge of the biogeography and ecology of the Sonoran Desert. Together, these data suggest that the monument has lost a significant portion of its historic complement of species and these changes will likely intensify as

  2. Itinerario de una arquitectura poética: las casas de Pablo Neruda

    Directory of Open Access Journals (Sweden)

    Majorie Agosín

    1992-12-01

    Full Text Available Con el advenimiento del gobiemo democrático de Patricio Alwyn en 1990, finaliza un legado de terror y despotismo de aproximadamente diecisiete años en Chile. La censura y Ia autocensura que tanto modificaron el espíritu creativo de la nación se encuentra lleno de energía y apertura y uno de los logros de mayor envergadura después de Ia derrota de Pinbchet consiste en las casas de Pablo Neruda, abiertas después de una clausum obligatoria par la dictadura militar.

  3. PROGRAMA “MINHA CASA, MINHA VIDA” COMO DIREITO FUNDAMENTAL SOCIAL À MORADIA

    OpenAIRE

    Silva, Juscelino Soares da; Silva, Jardel Pereira da

    2015-01-01

    O presente artigo objetiva analisar a moradia como direito fundamental social, ressaltando a necessidade de intervenção do Estado para a efetivação desse direito através da efetivação de políticas públicas, destacando o caso específico do programa social “Minha Casa, Minha Vida”. A pesquisa foi desenvolvida através de fonte documental e de instrumentos normativos, utilizando a doutrina e método dedutivo. Para maior compreensão do assunto abordado optou-se por dividir o trabalho em quatro part...

  4. The Political Agency of Victims in Atrocity Tales by Bartolomé de las Casas

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2016-01-01

    de las Casas, who is very often regarded as a precursor of modern human rights. I will argue that this atrocity tale is split between ethical universalism and international politics and that the image of the ‘victims’, that is, the American Indians, shifts like in a puzzle picture. The victims...... are both helpless, universalized bodies that are slaughtered by the Spanish, and in this way expose what Judith Butler has called a ‘primary vulnerability’ (Butler ) and they are potential political agents: inhabitants of defined political communities in the New World who have the right to protest against...... publication of this book in 1598....

  5. Don José Joquín Casas : un hombre una época

    Directory of Open Access Journals (Sweden)

    Rafael Azula Barrera

    1966-03-01

    Full Text Available Debo a las generosas instancias del reverendo padre Félix Restrepo -cuyo tránsito terrenal, concluído al finalizar el año último, se halla constelado de hazañas que reclaman ser esculpidas, como alto relieves, en el propio pedestal de la estatua que la gratitud nacional habrá de levantar a su nombre el honor inmerecido de pronunciar las palabras de rigor, al conmemorar nuestro instituto, en este día del idioma, el primer centenario del nacimiento de don José Joaquín Casas.

  6. Effect of semen preparation on casa motility results in cryopreserved bull spermatozoa.

    Science.gov (United States)

    Contri, Alberto; Valorz, Claudio; Faustini, Massimo; Wegher, Laura; Carluccio, Augusto

    2010-08-01

    Computer-assisted sperm analyzers (CASA) have become the standard tool for evaluating sperm motility and kinetic patterns because they provide objective data for thousands of sperm tracks. However, these devices are not ready-to-use and standardization of analytical practices is a fundamental requirement. In this study, we evaluated the effects of some settings, such as frame rate and frames per field, chamber and time of analysis, and samples preparations, including thawing temperature, sperm sample concentration, and media used for dilution, on the kinetic results of bovine frozen-thawed semen using a CASA. In Experiment 1, the frame rate (30-60 frame/s) significantly affected motility parameters, whereas the number of frames per field (30 or 45) did not seem to affect sperm kinetics. In Experiment 2, the thawing protocol affects sperm motility and kinetic parameters. Sperm sample concentration significantly limited the opportunity to perform the analysis and the kinetic results. A concentration of 100 and 50 x 10(6) sperm/mL limited the device's ability to perform the analysis or gave wrong results, whereas 5, 10, 20, and 30 x 10(6) sperm/mL concentrations allowed the analysis to be performed, but with different results (Experiment 3). The medium used for the dilution of the sample, which is fundamental for a correct sperm head detection, affects sperm motility results (Experiment 4). In this study, Makler and Leja chambers were used to perform the semen analysis with CASA devices. The chamber used significantly affected motility results (Experiment 5). The time between chamber loading and analysis affected sperm velocities, regardless of chamber used. Based on results recorded in this study, we propose that the CASA evaluation of motility of bovine frozen-thawed semen using Hamilton-Thorne IVOS 12.3 should be performed using a frame rate of 60 frame/s and 30 frames per field. Semen should be diluted at least at 20 x 10(6) sperm/mL using PBS. Furthermore, it is

  7. The effect of tracking network configuration on GPS baseline estimates for the CASA Uno experiment

    Science.gov (United States)

    Wolf, S. Kornreich; Dixon, T. H.; Freymueller, J. T.

    1990-01-01

    The effect of the tracking network on long (greater than 100 km) GPS baseline estimates was estimated using various subsets of the global tracking network initiated by the first Central and South America (CASA Uno) experiment. It was found that best results could be obtained with a global tacking network consisting of three U.S. stations, two sites in the southwestern Pacific, and two sites in Europe. In comparison with smaller subsets, this global network improved the baseline repeatability, the resolution of carrier phase cycle ambiguities, and formal errors of the orbit estimates.

  8. Garoto-propaganda Casas Bahia: configuração e estratégia

    OpenAIRE

    João, Aléxon Gabriel

    2015-01-01

    O fio condutor da análise dos anúncios é a construção discursiva, passando pelos princípios norteadores de Bakhtin que entende o texto como um suporte material que dialoga em diferentes níveis com o consumidor. Além do teórico russo, foram incorporados os conceitos de Eliseo Verón, Patrick Charaudeau e Paolo Fabbri. No caso do Garoto-propaganda Casas Bahia, a forma, o estilo e a maneira de anunciar os produtos da empresa parecem apontar para estratégias e movimentos muito peculiares que favor...

  9. Implementing an open-access CASA software for the assessment of stallion sperm motility: Relationship with other sperm quality parameters.

    Science.gov (United States)

    Giaretta, Elisa; Munerato, Mauro; Yeste, Marc; Galeati, Giovanna; Spinaci, Marcella; Tamanini, Carlo; Mari, Gaetano; Bucci, Diego

    2017-01-01

    Setting an open-access computer assisted sperm analysis (CASA) may benefit the evaluation of motility in mammalian sperm, especially when economic constraints do not allow the use of a commercial system. There have been successful attempts to develop such a device in Zebra fish sperm and the system has been used in very few studies on mammalian spermatozoa. Against this background, the present study aimed at developing an open-access CASA system for mammalian sperm using the horse as a model and based upon the Image J software previously established for Zebra fish sperm. Along with determining the sperm progressive motility and other kinetic parameters (such as amplitude of lateral head displacement), the "results" window was adjusted to simplify subsequent statistical analyses. The path window was enriched with colored sperm trajectories on the basis of the subpopulation they belong to and a number that allowed the sperm track to be associated to the sperm motility data shown in the "results" window. Data obtained from the novel plugin (named as CASA_bgm) were compared with those of the commercial CASA Hamilton-Thorn IVOS Vers.12, through Bland Altman's plots. While the percentage of total and progressive motile sperm, VCL, VAP, VSL, LIN and STR and ALH were in agreement with those obtained with the commercial system, BCF significantly differed between the two systems probably due to their settings. Interestingly, a positive and significant correlation between the percentages of total motile sperm evaluated through CASA_bgm and those showing high mitochondrial membrane potential evaluated by JC-1 staining was found. In conclusion, CASA_bgm ImageJ plugin could be useful and reliable for stallion sperm motility analysis and it is our aim to apply this system to other mammalian species. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. La restauración de la Casa Yamamura de Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Hidekazu Nishizawa

    2004-12-01

    Full Text Available La Casa Yamamura, proyectada por el arquitecto en 1918 para un solar ubicado en Ashiya (Hyogo, se aleja en su diseño del resto de su obra japonesa para acercarse a las características de su etapa californiana. Su singularidad se reflejó en su declaración como Bien de Interés Cultural en 1974, como primer edificio de la era Taisho (1912-1926 que recibía tal distinción. A principios de los años ochenta, la casa, en estado de desidia, fue objeto de estudio y restauración. Posteriormente, el terremoto de Kobe de 1995 afectó seriamente al edificio, de manera que se debió emprender una nueva restauración que constituye el contenido principal de este artículo.

  11. SENTIDOS DE DESACOLHIMENTO DE MÃES SOCIAIS DOS SISTEMAS DE CASAS LARES

    Directory of Open Access Journals (Sweden)

    Paulo André Sousa

    2015-04-01

    Full Text Available A institucionalização de crianças brasileiras é um fenômeno histórico. A presente pesquisa teve por objetivo problematizar os sentidos produzidos pelas mães sociais de uma casa de acolhimento no que diz respeito ao desligamento das crianças em situação de acolhimento prolongado, sendo realizada em uma ONG que trabalha com o sistema "Casa Lar". A coleta de dados foi efetuada a partir de um grupo focal, com o uso de um roteiro de entrevista semiestruturado. Os dados foram interpretados com base na análise semiótica, sendo centrais os conceitos de "Produção de Sentidos" e "Práticas Discursivas". Os sentidos construídos pelas mães sociais em relação às crianças e, principalmente, ao seu desligamento, alternam entre sentimentos maternais, até conclusões pessimistas quanto ao futuro desses jovens, fazendo da contradição, da incerteza e do afeto as marcas da vivência de tais profissionais.

  12. Paradigm, experiment and conclusion: La Casa by Bernard Rudofsky in three acts

    Directory of Open Access Journals (Sweden)

    Héctor García-Diego Villarías

    2018-04-01

    Full Text Available La Casa –or in English, the house– that Bernard Rudofsky built on the Spanish Mediterranean coast in 1971 is a valuable case study on the operational possibilities of popular architecture in the practice of this contemporary discipline. It is a repository of theoretical references typical of the vernacular world; its author, known for the exhibition Architecture without Architects, is emblematic of this type of architecture to which he dedicated much of his efforts as a theorist and polemicist throughout the course of his life. Additionally, La Casa is a unique architectural feat as it involves the practical materialization of its implicated theoretical position. It is possible that a concrete conclusion can be drawn from this case, which may shed light on the possible operability of a type of architecture that presents more than a few difficulties for the current context of the discipline, despite being habitually admired and praised. Additionally, the text presented here brings to light unpublished information found in the personal diaries of the architect that allows for the recreation of the circumstances surrounding the ideation and construction of this piece of architecture.

  13. Documenting Modern Mexican Architectural Heritage for Posterity: Barragan's Casa Cristo, in Guadalajara, Mexico

    Science.gov (United States)

    Mezzino, D.; Pei, W.; Santana Quintero, M.; Reyes Rodriguez, R.

    2015-08-01

    This contribution describes the results of an International workshop on documentation of historic and cultural heritage developed jointly between Universidad de Guadalajara's Centro Universitario de Arte, Arquitectura y Diseño (CUAAD) and Carleton University's Architectural Conservation and Sustainability Program. The objective of the workshop was to create a learning environment for emerging heritage professionals through the use of advanced recording techniques for the documentation of modern architectural heritage in Guadalajara, Mexico. The selected site was Casa Cristo, one of the several architectural projects by Luis Barragán in Guadalajara. The house was built between 1927 and 1929 for Gustavo R. Cristo, mayor of the city. The style of the building reflects the European influences derived from the architect's travel experience, as well as the close connection with local craftsmanship. All of these make the house an outstanding example of modern regional architecture. A systematic documentation strategy was developed for the site, using different survey equipment and techniques to capture the shape, colour, spatial configuration, and current conditions of Casa Cristo for its eventual rehabilitation and conservation.

  14. Dilemas de autenticidad: la restauración de la Casa Freeman de Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Chusid

    2015-06-01

    Full Text Available El artículo expone una breve descripción histórica ilustrativa del proceso de encargo, diseño y construcción de la casa con los bloques prefabricados característicos de la etapa californiana de Wright y de la vida posterior del edificio, centro neurálgico de la actividad de vanguardia artística de Los Ángeles, con sustanciales modificaciones llevadas a cabo por otros arquitectos afamados como Rudolph Schindler, Gregory Ain and John Lautner. En el texto se refleja no solo la tremenda complejidad técnica de restaurar esta casa erigida con un sistema constructivo sugerente pero tremendamente frágil y problemático y la dificultad añadida de su presencia en zona sísmica y los daños sufridos por el terremoto de Los Ángeles de 1994, sino también el dilema que surge a la hora de escoger eventualmente qué fase restaurar del edificio entre toda la estratificación de intervenciones de arquitectos estrella que caracteriza a este edificio.

  15. Organizaçao e funcionamento duma casa de abrigo de solidariedade social

    Directory of Open Access Journals (Sweden)

    Maria Jose Magalhaes

    2011-12-01

    Full Text Available A organização e o funcionamento de uma casa de abrigo de uma instituição humanista não feminista (chamada de "Solidariedade Social" constituiu o foco central desta pesquisa. Para isto, realizaram-se entrevistas semi-estruturadas às profissionais: à diretora da instituição, à diretora técnica e ao psicólogo. A análise apresenta uma visão de uma casa de abrigo normativa sobre o que deve ser uma mulher, incluindo as suas rotinas diárias, associada a uma organização rígida no que diz respeito a regras e horários. Mais ainda, perspectivando a mulher apenas como mãe e doméstica, esta perspectiva apresenta uma elevada tolerância à violência de gênero. A este respeito, este tipo de instituições corre sério risco de cair na perspectiva de "revitimizar" a vítima.

  16. Horizonte construido. Transformación del paisaje en la Casa Huarte

    Directory of Open Access Journals (Sweden)

    Pablo Olalquiaga Bescós

    2014-02-01

    Full Text Available La Casa Huarte (Madrid, 1966 representa, ante todo, una actuación en el paisaje. Sus creadores, José Antonio Corrales y Ramón Vázquez Molezún, invirtieron un método utilizado en proyectos anteriores (Instituto en Herrera de Pisuerga, Residencia en Miraflores, Pabellón de Bruselas donde la edificación se adecuaba al medio y el paisaje donde se insertaba. Mediante una transformación topográfica Corrales y Molezún construyeron un lugar en el que el horizonte, entendido como el paisaje formado por el encuentro de planos donde converge nuestra mirada, fue modificado. Cuando esto ocurre se produce una alteración de la mirada del observador, se “construye” un nuevo horizonte visual que es en definitiva el horizonte de la arquitectura, en el que los límites están definidos por los distintos planos. En esta construcción del nuevo horizonte, en la creación de nuevas experiencias visuales, las esculturas y los árboles, situadas en las plataformas de los patios de la Casa Huarte, se convirtieron en referencias visuales que alteraban los ángulos de visión previamente establecidos por la arquitectura. Estas siluetas incorporan nuevos puntos de referencia en ese horizonte, proporcionando profundidad, perspectiva y una escala intermedia entre la intimidad del observador y la monumentalidad del infinito

  17. Território, desigualde e cidadania: o Programa Minha Casa, Minha Vida em Londrina

    Directory of Open Access Journals (Sweden)

    Eliane Barbosa Santos Pagani

    2013-12-01

    Full Text Available Este artigo tem como escopo tecer algumas reflexões sobre a relevância da perspectiva territorial para a gestão das políticas habitacionais. A Política Nacional de Habitação (2004 considera o direito à moradia para além de uma casa para morar, ou seja, este direito se concretiza quando o cidadão acessa também outros bens e serviços, permitindo o acesso à cidade em sua totalidade. Isto implica a moradia como direito de inclusão social, garantindo padrão mínimo de habitabilidade, infraestrutura, saneamento, mobilidade, transporte coletivo, equipamentos, serviços urbanos e sociais. Entendendo que são nos vários territórios da cidade que este direito se concretiza, em maior ou em menor proporção, busca compreender como foi considerado esta categoria analítica, cuja literatura considera como central para uma estratégia efetiva de inclusão social, em um empreendimento habitacional do Programa Minha Casa, Minha Vida no município de Londrina.

  18. Effects of diluting medium and holding time on sperm motility analysis by CASA in ram

    Directory of Open Access Journals (Sweden)

    Somayeh Mostafapor

    2014-06-01

    Full Text Available The aim of this study was to evaluate the effects of dilution rate and holding time on various motility parameters using computer-assisted sperm analysis (CASA. The semen samples were collected from three Ghezel rams. Samples were diluted in seminal plasma (SP, phosphate-buffered saline (PBS containing 1% bovine serum albumin (BSA and Bioexcell. The motility parameters that computed and recorded by CASA include curvilinear velocity (VCL, straight line velocity (VSL, average path velocity (VAP, straightness (STR, linearity (LIN, amplitude of lateral head displacement (ALH, and beat cross frequency (BCF. In all diluters, there was a decrease in the average of all three parameters of sperms movement velocity as the time passed, but density of this decrease was more intensive in SP. The average of ALH between diluters indicated a significant difference, as it was more in Bioexcell in comparison with the similar amount in SP and PBS. The average of LIN in the diluted sperms in Bioexcell was less than two other diluters in all three times. The motility parameters of the diluted sperms in Bioexcell and PBS indicated an important and considerable difference with the diluted sperms in SP. According to the gained results, the Bioexcell has greater ability in preserving motility of sperm in comparison with the other diluters but as SP is considered as physiological environment for sperm. It seems that the evaluation of the motility parameters in Bioexcell and PBS cannot be an accurate and comparable evaluation with SP.

  19. Casa comercial Uribe Ruiz Hermanos 1894 – 1916. El caso de una empresa familiar en Antioquia

    Directory of Open Access Journals (Sweden)

    Ana María Mesa Bedoya

    2011-01-01

    Full Text Available En el texto se describe el funcionamiento de la casa comercial Uribe Ruiz Hermanos que operó en Rionegro, Medellín y Manizales, localidades antioqueñas, desde 1894 hasta 1916. En Colombia desde medidos de siglo XIX las oportunidades para incrementar el comercio de exportación de materias primas e importación de manufacturas aumentaron. Antioquia fue una de las regiones más dinámicas del país en cuanto al desarrollo de relaciones comerciales e integración de mercados locales con centros urbanos gracias al comercio. Pedro y Estanislao Uribe Ruiz, fundadores de Uribe Ruiz Hermanos, organizaron su casa de comercio a través de la red parental con lo que aseguraron la continuidad del negocio y la confianza para invertir en diversos campos económicos, como era costumbre entre otros comerciantes antioqueños durante el siglo XIX. La principal fuente de consulta fue el archivo José María Uribe Uribe 1838-1921 en el que se encuentra información de las firmas comerciales José María Uribe e Hijos y Uribe Ruiz Hermanos.

  20. Implementation of novel statistical procedures and other advanced approaches to improve analysis of CASA data.

    Science.gov (United States)

    Ramón, M; Martínez-Pastor, F

    2018-04-23

    Computer-aided sperm analysis (CASA) produces a wealth of data that is frequently ignored. The use of multiparametric statistical methods can help explore these datasets, unveiling the subpopulation structure of sperm samples. In this review we analyse the significance of the internal heterogeneity of sperm samples and its relevance. We also provide a brief description of the statistical tools used for extracting sperm subpopulations from the datasets, namely unsupervised clustering (with non-hierarchical, hierarchical and two-step methods) and the most advanced supervised methods, based on machine learning. The former method has allowed exploration of subpopulation patterns in many species, whereas the latter offering further possibilities, especially considering functional studies and the practical use of subpopulation analysis. We also consider novel approaches, such as the use of geometric morphometrics or imaging flow cytometry. Finally, although the data provided by CASA systems provides valuable information on sperm samples by applying clustering analyses, there are several caveats. Protocols for capturing and analysing motility or morphometry should be standardised and adapted to each experiment, and the algorithms should be open in order to allow comparison of results between laboratories. Moreover, we must be aware of new technology that could change the paradigm for studying sperm motility and morphology.

  1. CASA-Mot technology: how results are affected by the frame rate and counting chamber.

    Science.gov (United States)

    Bompart, Daznia; García-Molina, Almudena; Valverde, Anthony; Caldeira, Carina; Yániz, Jesús; Núñez de Murga, Manuel; Soler, Carles

    2018-04-04

    For over 30 years, CASA-Mot technology has been used for kinematic analysis of sperm motility in different mammalian species, but insufficient attention has been paid to the technical limitations of commercial computer-aided sperm analysis (CASA) systems. Counting chamber type and frame rate are two of the most important aspects to be taken into account. Counting chambers can be disposable or reusable, with different depths. In human semen analysis, reusable chambers with a depth of 10µm are the most frequently used, whereas for most farm animal species it is more common to use disposable chambers with a depth of 20µm . The frame rate was previously limited by the hardware, although changes in the number of images collected could lead to significant variations in some kinematic parameters, mainly in curvilinear velocity (VCL). A frame rate of 60 frames s-1 is widely considered to be the minimum necessary for satisfactory results. However, the frame rate is species specific and must be defined in each experimental condition. In conclusion, we show that the optimal combination of frame rate and counting chamber type and depth should be defined for each species and experimental condition in order to obtain reliable results.

  2. Effects of diluting medium and holding time on sperm motility analysis by CASA in ram.

    Science.gov (United States)

    Mostafapor, Somayeh; Farrokhi Ardebili, Farhad

    2014-01-01

    The aim of this study was to evaluate the effects of dilution rate and holding time on various motility parameters using computer-assisted sperm analysis (CASA). The semen samples were collected from three Ghezel rams. Samples were diluted in seminal plasma (SP), phosphate-buffered saline (PBS) containing 1% bovine serum albumin (BSA) and Bioexcell. The motility parameters that computed and recorded by CASA include curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP), straightness (STR), linearity (LIN), amplitude of lateral head displacement (ALH), and beat cross frequency (BCF). In all diluters, there was a decrease in the average of all three parameters of sperms movement velocity as the time passed, but density of this decrease was more intensive in SP. The average of ALH between diluters indicated a significant difference, as it was more in Bioexcell in comparison with the similar amount in SP and PBS. The average of LIN in the diluted sperms in Bioexcell was less than two other diluters in all three times. The motility parameters of the diluted sperms in Bioexcell and PBS indicated an important and considerable difference with the diluted sperms in SP. According to the gained results, the Bioexcell has greater ability in preserving motility of sperm in comparison with the other diluters but as SP is considered as physiological environment for sperm. It seems that the evaluation of the motility parameters in Bioexcell and PBS cannot be an accurate and comparable evaluation with SP.

  3. Cuando dejan de ser bebés. Una experiencia en la casa infantil Universitaria

    Directory of Open Access Journals (Sweden)

    Karla Martorell Esquivel

    2007-01-01

    Full Text Available En el presente artículo se realiza un análisis reflexivo acerca de los procesos experimentados por los niños y las niñas entre los dos y los tres años, en relación con los cambios continuos y progresivos en las diferentes áreas del desarrollo, a saber socioafectiva, cognitivo-lingüístico y psicomotriz. Asimismo, se da a conocer la experiencia obtenida como docentes de la Casa Infantil Universitaria de la Universidad de Costa Rica en cuanto a las generalidades del desarrollo en esta edad. Las particularidades presentadas por la población infantil que asiste a la institución, así como las estrategias seguidas para su atención. Se hace referencia a la experiencia lograda durante el período del II Ciclo 2005 y el I Ciclo 2006, el cual constituyó una excelente oportunidad para favorecer el desarrollo integral de las personas de esas edades y el crecimiento profesional y personal de las maestras de la Casa Infantil Universitaria. Finalmente, se brindan algunas estrategias y consideraciones finales sobre cómo conducir y guiar a los niños y las niñas de esta edad en ambientes no escolarizados.

  4. Historia del Hogar Casa Cuna de la ciudad de Mendoza: La institución que permanece

    OpenAIRE

    Farias Carracedo, Ana Carolina

    2017-01-01

    Este trabajo presenta la historia del Hogar Casa Cuna en la ciudad de Mendoza, Argentina,desde sus orígenes, a principios del siglo XX, hasta la actualidad enmarcando dicha historia enel contexto legislativo nacional y provincial.En sus orígenes, la Casa Cuna fue fundada por las Damas de la Caridad. En 1950 el Estado, pormedio de la Dirección Provincial del Menor, se hizo cargo de dicha institución aunque delegó elcuidado de los niños a las Hermanas de Nuestra Señora del Rosario que desempeña...

  5. Gestión y organización de Casa Guatemala. Requisitos funcionales de un CRM

    OpenAIRE

    Gil de Avalle Muñoz, Maria

    2011-01-01

    Detección de los problemas actuales importantes de Casa Guatemala que impiden tener una buena organización y que, junto a la crisis económica mundial que se vive, impiden su resolución. · Diseño de una nueva organización estructurada y una nueva manera de gestionar Casa Guatemala que aporte beneficios, solucione su crisis interna y ayude a la falta de recursos económicos que se obtienen actualmente. · Descripción de nuevos canales de comunicación entre diferentes agentes de ...

  6. Development and Validation of the Coping with Acculturative Stress in American Schools (Casas-A) Scale on a Latino Adolescent Sample

    Science.gov (United States)

    Castro-Olivo, Sara M.; Palardy, Gregory J.; Albeg, Loren; Williamson, Ariel A.

    2014-01-01

    The psychometric properties of the Coping With Acculturative Stress in American Schools (CASAS-A) scale were examined using a sample of 148 Latino middle school students. CASAS-A is a self-report scale designed to identify students in need of culturally responsive social-emotional interventions due to having high levels of school-related…

  7. Cavernomas: conduta no serviço de neurocirurgia da Santa Casa de Belo Horizonte Cavernous malformations: surgical management in Belo Horizonte Santa Casa Hospital

    Directory of Open Access Journals (Sweden)

    Marcello Penholate Faria

    2004-12-01

    Full Text Available A melhor compreensão da história natural dos cavernomas, o aprimoramento dos métodos diagnósticos e das técnicas microcirúrgicas tornaram possíveis as seguintes condutas: tratamento conservador, radiocirurgia e ressecção cirúrgica. Apresenta-se revisão de 33 pacientes operados no serviço de Neurocirurgia da Santa Casa de Belo Horizonte, no período de 1992 a 2001. Cavernomas corticais e subcorticais que se manifestaram por crises convulsivas de difícil controle (57,5% ou principalmente por hemorragia (15,1% foram tratados cirurgicamente. As lesões profundas (gânglios basais, tálamo e tronco encefálico somaram 27,7%. Estas, atualmente, só devem ser operadas quando estão próximas à superfície ependimária ou pial. Indicou-se ainda a ressecção de lesões medulares (5,5% e cerebrais profundas, que apresentaram déficit focal progressivo(13,8% ou episódios recorrentes de hemorragia(13,8%. As lesões pequenas e profundas que não apresentam hemorragia devem ser tratadas conservadoramente.Não existe, no momento, evidência de resultados favoráveis com a radiocirurgia.The better understanding of the natural history of the cavernous malformations and the improvement of diagnostic methods and of microsurgical techniques have made the management of cavernous malformations possible through the conservative treatment, radiosurgery, and microsurgical resection. We present 33 cases operated at our service at Santa Casa Hospital, Belo Horizonte, from 1992 to 2001. Cortical and subcortical cavernomas manifested by epilepsy (57.5% or mainly by hemorrhage (15.1% were surgically approached. The deep lesions (basal ganglia, talamo and brain steam represented 27.7% of our cases. They should only be operated when located near the pial or ependimary surface. The resection of spinal cord lesions (5.5% and of deep brain lesions is also recommended when they present progressive focal deficit (13.8% or recurrent episodes of hemorrhage (13

  8. Efeitos de relações CaSO4/CaCO3 na mobilidade de nutrientes no solo e no crescimento do algodoeiro

    Directory of Open Access Journals (Sweden)

    A. A. Silva

    1998-09-01

    Full Text Available O experimento, realizado em casa de vegetação no Departamento de Ciência do Solo da Universidade Federal de Lavras, teve por objetivo estudar o efeito de diferentes relações de CaSO4/CaCO3, que simulam o uso de gesso e calcário, na movimentação de nutrientes no solo e no crescimento do algodoeiro, cultivar IAC-20. As proporções de CaSO4/CaCO3 utilizadas foram: 0/100, 25/75, 50/50, 75/25 e 100/0, com base em peso equivalente, além de um tratamento-testemunha, sem aplicação de CaSO4 e CaCO3. Observou-se acentuada movimentação de cálcio e de sulfato em profundidade, como íons acompanhantes, com o aumento da relação CaSO4/CaCO3. Para o N-NO3- e Mg2+, ao contrário do N-NH4+ e K+, observou-se um acúmulo em profundidade, com a elevação da relação CaSO4/CaCO3. Neste estudo, o gesso teve pouco ou nenhum efeito sobre a acidez e Al trocável presentes nas camadas subsuperficiais. A produção de matéria seca do algodoeiro foi reduzida com o aumento da relação CaSO4/CaCO3, porém, quando comparada à do tratamento-testemunha, a aplicação de gesso aumentou-a significativamente, atestando o potencial de uso do gesso agrícola.

  9. Diversity of amphibians and reptiles associated with grasslands of Janos-Casas Grandes, Chihuahua, Mexico (La diversidad de anfibios y reptiles asociada a los pastizales de Janos-Casas Grandes, Chihuahua, Mexico)

    Science.gov (United States)

    Georgina Santos-Barrera; Jesus Pacheco-Rodriguez

    2006-01-01

    Prairie-dog (Cynomys ludovicianus) colonies in northwest Chihuahua, Mexico, have been of great significance not only in initiating protection programs for the species but also in learning about the biological diversity (flora and fauna) of the natural grasslands of Janos-Casas Grandes, Chihuahua. Therefore a study of the herpetological fauna within the prairie-dog...

  10. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  11. Comerciantes-empresarios en el medio rural argentino a comienzos del siglo XX. El estudio de caso de los Hnos. Vulcano y su Casa de Comercio ‘El Progreso’

    Directory of Open Access Journals (Sweden)

    Valeria Palavecino

    2009-01-01

    Full Text Available Este trabajo aborda el rol que desempeñaron los comerciantes rurales en la administración de sus casas comerciales en el sur bonaerense, durante las primeras décadas del siglo XX. A partir de la basta producción teórica e historiográfi ca ligada a los conceptos de empresa y empresario, se plantean algunas cuestiones teórico-metodológicas que permiten comprender la utilización de estos conceptos en el caso estudiado. Se analizará la relación comerciante–cliente, el papel del crédito en la conformación de las carteras de clientes, y los lazos extra-comerciales que vincularon a estos empresarios con su entorno.

  12. Gasto y financiación de las casas reales de Felipe III

    Directory of Open Access Journals (Sweden)

    Carlos Javier de CARLOS MORALES

    2009-12-01

    Full Text Available RESUMEN: La situación económica de las Casas reales en tiempos de Felipe III reflejó una de las características básicas de la Real Hacienda castellana: la acumulación de atrasos y débitos daba lugar a un pasivo que tenía que ser trasladado de ejercicio en ejercicio. Esta dinámica no sólo era consecuencia de unos gastos corrientes crecientes, sino sobre todo de la ausencia de una fuente de sostenimiento fija a disposición del maestro de la cámara, cuya dependencia de la Tesorería general era causa del «déficit flotante» que debía manejar de año en año. Ante esta situación, en el reinado de Felipe III no dejaron de realizarse intentos para ajustar los ingresos y gastos y para dotar a las Casas reales de unos medios estables de sostenimiento, como la asignación de los millones. Pero las vicisitudes padecidas por la Real Hacienda impidieron la superación de la crónica falta de liquidez del erario, y determinaron que el recurso al crédito fuera una forma ineludible de financiación de las Casas reales.ABSTRACT: The economic situation of the Royal Houses in the times of Felipe the Third reflect one of the basic characteristics of the castilian Royal Treasury: the accumulation of arrears and debits caused liabilities that had to be transferred from financial year to financial year. These happenings were not only the consequence of growing ordinary expenses, but also the absence of a source of fixed maintenance at the chambermaster disposition, whose dependence of the general Treasury was the reason for a «floating déficit» he had to manage year after year. Confronted with this situation, during Felipe the Third's reign, there were any number of attempts to try to adjust the income and the expenses, and to provide the Royal Houses of stable means of maintenance, such as asigning the millions possessed. But the ups and downs suffered by the Royal Treasury didn't allow the overcoming of the chronic lack of settlement in the

  13. Heat transfer in simple houses; Transferencia de calor en casas habitacion

    Energy Technology Data Exchange (ETDEWEB)

    Porta, Miguel Angel; Rubio, Eduardo; Fernandez, Jose Luis [Centro de Investigaciones Biologicas del Noroeste, Baja California Sur, (Mexico); Gomez Munoz, Victor [Centro Interdiciplinario de Ciencias Marinas, Baja California Sur (Mexico)

    2000-07-01

    A lumped parameter model is used to represent, with a high degree of precision, the temperature and comfort evolution with the time of a simple house, under any hot, extreme weather variation. Results are validated by experimental work in physical models, built to scale 1:2, with materials and building techniques typical of social interest housing in Baja California, Mexico. With the mathematical model properly calibrated, adequately validated heat transfer coefficients between walls, ceiling and windows are calculated. Sensitivity analyses lead to values of heat loads in simple houses with varying shapes, orientation, shading devices, and construction materials and techniques. Energy balance in the present work is achieved by means of three simultaneous equations, each depicting energy equilibrium in one of the basic building elements: the window glazing, the building materials, and inside air. Simultaneous solution of the equations is accomplished with of the Kutta method, which yields the representative temperature along the day of each of the components, while heat flow among them is calculated, together with thermal exchange with the environment. Comfort levels, energy consumption and saving are hence easily derived, and the economical pertinence of passive elements can be evaluated. [Spanish] Este trabajo presenta un modelo matematico de parametros concentrados que representa, de manera apropiada, el comportamiento de una casa habitacion tipica a lo largo de un dia cualquiera. Los resultados se validan mediante la experimentacion en modelo fisico, donde se ensayan casetas de material y dimensiones similares a las casas de interes social, a escala 1:2. Una vez que se ha calibrado el modelo, se pueden determinar, mediante corridas apropiadas en computadora, los coeficientes especificos de transferencia de calor en muros, ventanas y techo. Los analisis subsecuentes de sensibilidad producen informacion util para conocer los requerimientos energeticos de cada casa

  14. ELEMENTOS GÓTICOS EN UNA CASA VACÍA DE CARLOS CERDA

    Directory of Open Access Journals (Sweden)

    Cristián Cisternas

    2010-04-01

    Full Text Available Este artículo es un análisis de la novela Una casa vacía (1996 del escritor chileno Carlos Cerda, basado en la identificación de elementos de imaginería gótica en distintos niveles de la obra. Se estudia el funcionamiento de estos elementos dentro del marco esencialmente realista de la obra, para intentar establecer los límites cruzados entre el testimonio, la historia oficial y sus metaforizaciones. La alegoría final que la obra novelesca construye en relación con la antigua casa de tortura y sus habitantes, se corresponde con el período final de la Dictadura Militar (1973-1989 y las prácticas de tortura realizadas por organismos de gobierno contra civiles. Sin embargo, también se trata de mostrar la dificultad del realismo testimonial para escribir una novela sobre la degradación y el sufrimiento de la sociedad chilena del período, sin caer en una ideología maniquea de la narración.This article is an analysis of Una casa vacía (1996, a novel written by the Chilean author Carlos Cerda. This analysis is based upon the identification of elements of the Gothic imaginary at different levels of this narrative. The functioning of these elements is studied within the basically realistic frame of the novel, in order to establish the permeable boundaries between testimonial narrative, the official history and its metaphorizations. The ultimate allegory that the novel builds around a former torture house and its inhabitants finds its correspondence with the final period of the Military Dictatorship (1973-1989 and the torture practices carried by Government Organizations against civilians. Nevertheless, this article tries to show the difficulty of testimonial realism in order to write a novel about the suffering and decadence of the Chilean society of the period, without succumbing to a Manichean concept of the narrative function.

  15. Pedro Ventura de Puga, último señor de la Casa de Fontefiz

    Directory of Open Access Journals (Sweden)

    Leirós de la Peña, Paz

    2007-12-01

    Full Text Available This paper is based on documentation from Casa de Fontefiz kept in the AHPOR. The documents cover the period from the sixteenth to nineteenth century and provide information about the patrimony of the house, its social position and the political activities of Pedro Ventura de Puga during the firts half of the nineteenth century. The first part is focused on the origin and evolution of patrimony, way of living, nobility abuses (including social and sexual aspects, and the difficulties to keep the social status. In the second part, Pedro Ventura plays the main role: his participation in the War of Independence and the building of the liberal state. He is a relevant character to undestand the adaptation of nobility to an age of political changes and social ad economical survivals. The defense of the constitution and his participation in the liberal regime is compatible with the maintenance of a economy based on the collection of taxes and nobility titles. Pedro Ventura is politically registered as a moderate liberalist.

    Este trabajo está basado en la documentación de la Casa de Fontefiz, conservada en al AHPOR. Los documentos abarcan desde el siglo XVI al XIX y nos aportan información sobre el patrimonio de la Casa, su posición social y las actividades políticas de Pedro Ventura de Puga en la primera mitad del siglo XIX. La primera parte se centra en el origen y evolución del patrimonio, modo de vida, abusos de la hidalguía en el plano social y sexual y las dificultades para mantener el stuatus social. La segunda parte tiene como protagonista a Pedro Ventura de Puga, su participación en la Guerra de la Independencia y en la construcción del estado liberal. Es una figura clave para entender la adaptación de la hidalguía a una época de cambios políticos y de pervivencias sociales y económicas. La defensa de la Constitución y la participación en el régimen liberal es compatible con el mantenimiento de una econocmía basada en

  16. La Casa de las Atarazanas de Valencia y Joan del Poyo (I

    Directory of Open Access Journals (Sweden)

    Iborra Bernad, Federico

    2007-06-01

    Full Text Available

    The construction of the House of the Dockyards in the coast line of the city by the local government was the result of the urban development policy of Valencia, showing that the city itself was centred in showing an image of propriety and beauty in every place, and also the influence of Martin I and his unsatisfied wishes of constructing a palace near the coast of Barcelona. Despite the fact that the original purpose of the building was to be used a warehouse of the port, the needs of the local government forced it to extend its functions turning it into a palace receiving prominent figures and being the emplacement of many ceremonies and banquets. The importance of the House of the Dockyards can be appreciated in its dimensions, as we can see in the engravings and landscapes illustrations of El Grao, and in the work produced by Joan del Poyo after returning from Barcelona, where he served the king Martin I, probably in the Royal Palace of the city.



    La construcción de la Casa de las Atarazanas en la línea litoral de la urbe por parte del gobierno municipal se debió tanto a la política urbanística emprendida por el patriciado urbano centrada en mostrar una imagen de belleza y decoro en todos sus frentes, como a la influencia que pudo haber ejercido Martín I en el reino de Valencia, y su deseo no satisfecho de edificar en Barcelona un palacio cercano a la costa. Aunque en un primer momento la finalidad del edificio fue la de servir de almacén de los productos del puerto, las necesidades de gobierno hizo ampliar sus funciones, asemejándose más a la de una casa o palacio, que acogería a personajes ilustres en su llegada marítima y sería el emplazamiento de ceremonias y ágapes. La importancia de la Casa de las Atarazanas se aprecia tanto en sus grandes dimensiones, como constatan los grabados e ilustraciones paisajísticas del

  17. 76 FR 15936 - Designation for the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND...

    Science.gov (United States)

    2011-03-22

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Designation for the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND; and Plainview, TX Areas AGENCY: Grain Inspection, Packers and Stockyards Administration, USDA. ACTION: Notice...

  18. 78 FR 43850 - Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ...

    Science.gov (United States)

    2013-07-22

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND and Plainview, TX; Areas; Request for Comments on the Official Agencies Servicing These Areas AGENCY: Grain...

  19. 75 FR 52925 - Opportunity for Designation in the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande...

    Science.gov (United States)

    2010-08-30

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND; and Plainview, TX Areas; Request for Comments on the Official Agencies Servicing These Areas AGENCY...

  20. Interações silício-fósforo em solos cultivados com eucalipto em casa de vegetação

    Directory of Open Access Journals (Sweden)

    Carvalho Rui

    2001-01-01

    Full Text Available Este trabalho teve o objetivo de avaliar as interações Si-P em dois solos, por meio do estado nutricional de P em mudas de Eucalyptus grandis sob efeito de aplicação de Si. Foram conduzidos dois experimentos em casa de vegetação, utilizando como substratos as camadas superficiais (0-20 cm de profundidade de um Latossolo Vermelho-Escuro fase cerrado e de um Cambissolo fase campo cerrado da zona fisiográfica Campos das Vertentes, MG . Cada solo foi submetido a três incubações seqüenciais: CaCO3 + MgCO3 para manter o pH em torno de 6, fertilização básica, incluindo o P em dose única, para manter 0,2 mg L-1 de P em solução e seis doses de Si (CaSiO3 definidas com base na dose de P. Foram avaliados a produção de matéria seca da parte aérea (MSPA, conteúdo de P e Si na MSPA e frações fosfatadas e fosfatase ácida em folhas apicais aos 60, 90 e 120 dias após o transplantio das mudas para os vasos. Ajustaram-se superfícies de resposta para essas variáveis em razão das doses de Si e das épocas. Mudas cultivadas no Cambissolo tiveram ganho de 15,25% no conteúdo de P na MSPA. Frações fosfatadas e atividade da fosfatase ácida em plantas não mostraram sensibilidade para avaliar a interação Si-P nos dois solos.

  1. João Andresen (1920/1967) : o projecto da casa Ruben A.

    OpenAIRE

    Pinto, Luís Miguel Rodrigues Moreira

    2011-01-01

    Dissertação de mestrado em Arquitectura. Exame público realizado em 11 de Julho de 2011. A dissertação aborda o projecto da Casa em Montedor que o arquitecto João Andresen projecta no final dos anos 40 para o escritor Ruben A. O ambiente de adesão e afirmação moderna que se vive na arquitectura portuguesa explica a interpretação genérica de um programa específico, a prioridade dada aos aspectos funcionais e o modo como a construção se relaciona, por oposição, com a paisagem. A confronta...

  2. Restauración de la casa doble de Le Corbusier en la Weissenhofsiedlung

    Directory of Open Access Journals (Sweden)

    Arne Fentzloff

    2014-07-01

    Full Text Available La Casa Doble diseñada por Le Corbusier en 1927 para la Weissenhofsiedlung constituye un hito en el diseño y construcción de viviendas en el Movimiento Moderno. Su precario estado de conservación requería una restauración que la Fundación Wüstenrot ha acometido con la voluntad no de repristinar necesariamente a su condición originaria, sino de restaurar el conjunto y habilitarlo para la visita pública conservando al menos parcialmente las diversas reformas y adaptaciones de uso que había sufrido estas viviendas pareadas durante sus años de historia. El texto explica abundantes detalles constructivos de su proceso de diseño y construcción y revela las soluciones técnicas adoptadas durante la restauración.

  3. Convocatoria al Premio Literario Casa de las Américas 2004

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    2001-09-01

    Full Text Available Premio extraordinario sobre estudios de la mujer. La Casa de las Américas convoca, por segunda vez, al Premio extraordinario de ensayo sobre estudios de la mujer, dedicado a ampliar el conocimiento de obras, figuras o grupos de mujeres latinoamericanas y del Caribe que se hayan destacado en cualquier campo de la vida intelectual, social o política. Los libros que concursen se someterán a las bases generales del Premio y podrán ser enviados a cualquiera de los lugares enumerados en la base 8 antes del 30 de noviembre de 2003. El fallo del jurado será dado a conocer conjuntamente con el de los demás premios en enero de 2004.

  4. “En tu casa o en la mía’: the interview as infotainment

    Directory of Open Access Journals (Sweden)

    Marián Alonso González

    2016-11-01

    Full Text Available The fight for viewers has led to a spectacular range of television content on offer where boundaries of genres have disappeared giving rise to new formats of hybrid television programmes. This has given a new lease of life to interviews as a genre of infotainment. The present article analyses the programme ‘En tu casa o en la mía’, a new type of interview of famous personalities which combines information and entertainment with elements that are very similar to the info-show. We shall embark on a study of this media product, its narrative, treatment, structure and the technique used so as to describe the elements that make it an example of gender hybridization in today’s television programmes.

  5. Evaluación de los resultados del programa 'Parto en el hospital, comadrona en casa'

    OpenAIRE

    Crespo Mirasol, Esther; España, M.Carmen; Basteiro, Elena; Zegarra, Mary Michel; Botet Mussons, Francisco; Pérez, José María; Arranz Betegón, Ángela; Palacio i Riera, Montserrat

    2015-01-01

    Objetivo: Describir las características y la evolución clínica de las puérperas y los neonatos incluidos en un programa de alta precoz hospitalaria. Material y método: Estudio observacional y descriptivo de la población incluida en el programa «Parto en el hospital, comadrona en casa», del Hospital Clínic de Barcelona, desde octubre de 2010 hasta abril de 2013. Resultados: Participaron un total de 150 madres, con una edad (media ± desviación estándar) de 32 ± 4 años. El 70% (n= 105) eran mult...

  6. La casa de Fermina Daza. Retrato de Gabo con loro al fondo

    OpenAIRE

    Rodríguez Blanco, Sergio

    2014-01-01

    Extracto de la crónica: "Gabriel García Márquez ubicó aquí la casa de soltera de la altiva Fermina Daza, la protagonista de El amor en los tiempos del cólera, una novela ambientada en una población imaginaria que se parece en todo a Cartagena de Indias a principios del siglo XX. Cada día, para obtener una mirada furtiva de su amada, el joven Florentino Ariza iba al parque de los Evangelios y fingía leer poemas sentado a la sombra de los almendros, desde el escaño menos visible de los que rode...

  7. “La Casa de las Flores”: arquitectura urbana-manifiesto de Secundino Zuazo /

    Directory of Open Access Journals (Sweden)

    Duarte, Patricio; Gurovich, Alberto; Pavez, M.Isabel.

    2007-06-01

    Full Text Available La "Casa de las Flores" es un interesante proyecto de arquitectura urbana residencial -bloques de departamentos de alquiler- del arquitecto bilbaíno Secundino Zuazo Ugalde (tit. 1912, m. en 1970. Realizado entre 1930 y 1932, es uno de los tres conjuntos más representativos del Movimiento Moderno en Madrid, y fue declarado Monumento Nacional en 1981. En uno de los pisos de este conjunto residió el Premio Nobel de literatura Pablo Neruda.This is a remarkably housing project -apartments for rent- of Secundino Suazo. The building –National Monument since 1981- is representative of the Modern Movement of Madrid as well as a fine example of urban architecture. Pablo Neruda, the Chilean Nobel Prize in Literature, was a resident there.

  8. Bartolomé de Las Casas: una mirada política de la encomienda

    Directory of Open Access Journals (Sweden)

    Edwin Camacho Quintero

    2008-01-01

    Full Text Available La gura de Bartolomé de Las Casas es problemática, oscila entre los extremos que ven en él un Santo militante en la causa de la humanidad o un demente guiado por complejos narcisistas más que por un sentido humanitario hacia los indios. Tras la maraña de interpretaciones, diatribas y apologías tejidas durante casi cinco siglos, su pensamiento ofrece terrenos aún inexplorados en espe - cial su última etapa de maduración al interior del iusnaturalismo salmantino. Desde esta perspectiva, su tratamiento del problema de la encomienda trasciende los aspectos morales para ofrecer una mirada política que tiene como supuesto la consolidación del Estado absolutista español, y la reproducción problemática de prácticas medievales en el gobierno de las Indias.

  9. Conquista, dominación y alteridad en Bartolomé de Las Casas

    Directory of Open Access Journals (Sweden)

    Luis Adrián Mora Rodríguez

    2011-11-01

    Full Text Available El presente artículo pretende efectuar un acercamiento innovador a la obra de Bartolomé de Las Casas. Se plantea que dicha obra debe ser abordada como una obra de teoría y de filosofía política, más allá de su importancia como obra ética o histórica. Se argumenta que dicho acercamiento permite observar y criticar las variantes del discurso lascasiano y profundizar sus conexiones y puentes con el pensamiento político moderno. Se trazan de esta manera algunas líneas de investigación posibles.

  10. CASA: An Efficient Automated Assignment of Protein Mainchain NMR Data Using an Ordered Tree Search Algorithm

    International Nuclear Information System (INIS)

    Wang Jianyong; Wang Tianzhi; Zuiderweg, Erik R. P.; Crippen, Gordon M.

    2005-01-01

    Rapid analysis of protein structure, interaction, and dynamics requires fast and automated assignments of 3D protein backbone triple-resonance NMR spectra. We introduce a new depth-first ordered tree search method of automated assignment, CASA, which uses hand-edited peak-pick lists of a flexible number of triple resonance experiments. The computer program was tested on 13 artificially simulated peak lists for proteins up to 723 residues, as well as on the experimental data for four proteins. Under reasonable tolerances, it generated assignments that correspond to the ones reported in the literature within a few minutes of CPU time. The program was also tested on the proteins analyzed by other methods, with both simulated and experimental peaklists, and it could generate good assignments in all relevant cases. The robustness was further tested under various situations

  11. Evaluación sustentable "CASA HABITACION" en el Municipio de Tlaxcala, Tlax. México.

    OpenAIRE

    Raúl Molina Rivera

    2012-01-01

    El artículo mostrará la evaluación realizada por medio del software de diseño Bioclimática Ecotect Analysis1 y de evaluación sustentable como ARTEBES2 a un proyecto de casa habitación que fue sometido a modificaciones sencillas, económicas y muy accesibles en la región, que optimizaran el uso de las energías renovables y ayudarán a la reducción de consumo de energías no-renovables para reducir los gastos económicos necesarios para el funcionamiento de la vivienda. Presentando una breve descri...

  12. O Programa Minha Casa Minha Vida e seus resultados formais em Uberaba (MG: residencial Tancredo Neves

    Directory of Open Access Journals (Sweden)

    Carmem Silvia Maluf

    2014-12-01

    Full Text Available This article proposes the discussion of the housing policy “Minha Casa Minha Vida” (“My House My Life”, its consequences and recurrent transformations for urban space, with focus in the analysis of the urban morphology resulting from Tancredo Neves residential subdivision, located in the municipality of Uberaba (MG, Brasil. This social housing has some single features, differing of other social housing, since the public intended to misuse of Permanent Preservation Areas (APP by the residents. The results of this analysis reinforce the importance of government in promoting housing, and identifies the recurrent reproducibility of housing models, and show how this proliferation of housing units impacts on urban morphology, bringing with questionable consequences for the landscape.

  13. Cultural diversity in Brazilian children’s literature: The project Literatura em Minha Casa in question

    Directory of Open Access Journals (Sweden)

    Flávia Ferreira de Paula

    2016-08-01

    Full Text Available This paper intends to search for representations of Brazilian cultural diversity in children’s literature of the Programa Nacional Biblioteca da Escola [National Program of School Library] (PNBE, in the editions of 2001, 2002, and 2003, years of the project Literatura em Minha Casa [Literature in My House], especially those addressed to fourth and fifth grades of Elementary School. The selection criteria of works claimed that the collections should “[…] present a small picture of the Brazilian culture […]” (Brasil, 2001; 2002; 2003, p. 12, understanding that culture as characterized by diversity. Therefore, the analysis was divided into two phases: the first dealt with ethnic plurality and the second with culture and regionalism. In general, the results showed that among 120 works analyzed, 15 had ethnic-racial diversity and 12 works presented aspects of regionalism and culture from different parts of Brazil.

  14. The Discursive Representation of Dictatorship in Lygia Bojunga’s A casa da madrinha

    Directory of Open Access Journals (Sweden)

    Alice Atsuko Matsuda

    2015-07-01

    Full Text Available The children’s novel A casa da madrinha [The Godmother's House], by Lygia Bojunga (2002, published in 1978, incorporates libertarian ideals of the children’s and youth production of that decade. Its plot breaks with the tradition of euphoric literary production around the 1940s and 1950s, intended to children and young people, talks about taboo subjects like abandonment of minors and child labor, bringing to the center an inhuman social reality in which children and youths are neither protected nor supported or respected, having their rights disregarded. This justify, thus, the objective of this text, which is to analyze how these ideals are configured in the discursive representation of said work, considering that it was published during a military dictatorship.

  15. Housing for the poor: Implementation and impact of Tu Casa program in Tijuana

    Directory of Open Access Journals (Sweden)

    Ana Elizabeth Jardón Hernández

    2009-01-01

    Full Text Available This study assesses the operation and some major results of most important federal housing program focus on households in poverty situation, with particular emphasis on their instrumentation process and impacts in Tijuana’s housing problem for poor families. The exam aims to analyses the design changes of the program that forced its transformation from Vivah to Tu Casa, and the operational difficulties for a proper implementation in an urban context, as well as its limited impact for solving popular housing needs. It also seeks to weigh the importance of government subsidies to acquire or improve housing, in their progressive modality, as an alternative for social segments excluded from any other public or private financing option.

  16. Evaluation of the Township Proper Carrying Capacity over Qinghai-Tibet plateau by CASA model

    Science.gov (United States)

    Wu, Chengyong; Cao, Guangchao; Xue, Huaju; Jiang, Gang; Wang, Qi; Yuan, Jie; Chen, Kelong

    2018-01-01

    The existing study of proper carrying capacity (PCC) has mostly focused on province or county administrative units, which can only macroscopically master the quantitative characteristics of PCC, but could not effectively take some animal husbandry management measures that are pertinent and operational. At town-scale, this paper used CASA model to estimate the PCC in Mongolian Autonomous County of Henan, Qinghai province, China,with serious grassland degeneration that mainly caused by overgrazing. The results showed that the PCC throughout the County was 950,417 sheep unit. For the township, the PCC of Saierlong and Duosong were the largest (247,100 sheep unit) and the smallest (82,016 sheep unit) respectively. This study will provide reference data for developing sustainable development of town-scale pasture policies and also will help to evaluate the health status of the alpine grassland ecosystem on Qinghai-Tibet plateau.

  17. La casa de Halldor Gunnløgsson (1959. Una mirada a Oriente desde el Sund

    Directory of Open Access Journals (Sweden)

    Carmen García Sánchez

    2017-04-01

    Full Text Available La casa de Halldor Gunnløgsson, una de las obras más refinadas de la Edad de Oro de la arquitectura moderna danesa, es el resultado de una fuerte voluntad y disciplina artística personal. La cubierta plana, suspendida sobre una gran plataforma pavimentada –que continúa la construcción del lugar– tiene una gran presencia. En el interior, un espacio único, fluye libremente y se extiende al paisaje. Hay una extraordinaria sofisticación de la construcción vernácula; y una fuerte conexión con la arquitectura tradicional japonesa, revelada por el deseo de vivir en estrecho contacto con la naturaleza, la búsqueda del refinamiento mediante la moderación, la eliminación de los elementos superfluos y la preocupación por la luz y la sombra –estableciéndose un paralelismo con el oscuro invierno nórdico. Su característica abstracción es un ejemplo de modernidad. El edificio se acerca a la belleza clásica, por la aparición de proporción, simetría y orden, pero también por el tratamiento suave de las superficies de los materiales. Se reconoce un ritmo en diferentes dimensiones. Se valora la escala. Los colores aplicados o inherentes al material, alcanzan intensidad. La experiencia del espacio arquitectónico es global. Es una casa mágica y maravillosa.

  18. The intertext of modernism in Crônica da casa assassinada, de Lúcio Cardoso

    Directory of Open Access Journals (Sweden)

    William Valentine Redmond

    2015-11-01

    Full Text Available AbstractThis article reflects on the many opinions about the author of the of Crônica da casa assassinada as a modernist or postmodernist writer.  Examining the narrative techniques used by the author, maybe influenced by his wide reading of foreign literatures , it may be possible to clarify a little the question of the position of Lucio Cardoso in relation to the literary movements of the twentieth century. His personal experience as a writer passes through the process of impersonalisation, transforming his masterpiece into a universal symbol.  It is hoped that this paper will show how this transformation of his personal experience comes across to the readers in the form of a modernist and not as some say, a post modernist novel. Resumo: Este artigo reflete sobre as muitas opiniões acerca do autor da Crônica da casa assassinada como um escritor modernista ou pós-modernista. Examinando as técnicas narrativas utilizadas pelo autor, talvez influenciado por sua vasta leitura de literaturas estrangeiras relatadas,  seria possível clarear um pouco esta questão da posicionamento de Lucio Cardoso com relação aos movimentos literários do século XX. A experiência pessoal do escritor passa por um processo de impessoalidade, através da transmutação e amalgamação, transformando a obra em símbolo universal. Espera-se com esta comunicação discutir o modo como essa transmutação chega ao leitor em forma de um romance modernista e não, como às vezes se afirma, como um romance pós-modernista. 

  19. HISTORIZAR LA VIOLENCIA PUERTAS ADENTRO. EL CASO DE LA CASA YELA Y LA VIOLENCIA DE GENERO EN TALCA, 1964-2008

    OpenAIRE

    CARROLL HINER, HILLARY; CARROLL HINER, HILLARY

    2012-01-01

    Nuestra investigación se concentra en el caso de la Casa de la Mujer "Yela" en Talca, sede de una organización de mujeres - el Grupo Yela - y casa de acogida. La historia de esta Casa remite a una historia más larga de lucha y organización femenina y proponemos que las experiencias de las mujeres "Yela" tienen sus raíces en la llegada de las mujeres a las poblaciones del extremo barrio norte de Talca durante los años 60 y 70 y en las décadas de lucha colectiva emprendida por estas mujeres des...

  20. crdi.ca

    International Development Research Centre (IDRC) Digital Library (Canada)

    et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

  1. INTRACELLULAR Ca2+ HOMEOSTASIS

    Directory of Open Access Journals (Sweden)

    Shahdevi Nandar Kurniawan

    2015-01-01

    Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

  2. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population.

    Science.gov (United States)

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-03-01

    An international NGO, with financial and managerial support from "partner" communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala-an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access to referral care is facilitated. We conducted a mixed-methods study in San Sebastian Coatán municipality to assess the contribution of 2 Casas Maternas to health facility deliveries among partner and non-partner communities, with particular emphasis on equity in access. We surveyed all women who delivered in the study area between April 2013 and March 2014, the first full year in which both Casas Maternas in the study area were operating. In addition, using purposive sampling, we conducted in-depth interviews with 22 women who delivered and 6 focus group discussions with 42 community leaders, traditional birth attendants, and Casas Maternas staff members. We analyzed the quantitative data using descriptive statstics and the qualitative data with descriptive content analysis. Of the 321 women eligible for inclusion in the study, we surveyed 275 women (14.3% could not be located or refused to participate). Between April 2013 and March 2014, 70% of women living in partner communities delivered in a health facility (54% in a Casa Materna) compared with 30% of women living in non-partner communities (17% in a Casa Materna). There was no statistically significant difference in uptake of the Casa Materna by maternal education and only a weak effect by household wealth. In contrast, distance from the Casa Materna had a pronounced effect. Traditional birth attendants were strong advocates for utilization of the Casa Materna and played an important role in the decision regarding where the birth would take

  3. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population

    Science.gov (United States)

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-01-01

    ABSTRACT Background: An international NGO, with financial and managerial support from “partner” communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala—an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access to referral care is facilitated. Methods: We conducted a mixed-methods study in San Sebastian Coatán municipality to assess the contribution of 2 Casas Maternas to health facility deliveries among partner and non-partner communities, with particular emphasis on equity in access. We surveyed all women who delivered in the study area between April 2013 and March 2014, the first full year in which both Casas Maternas in the study area were operating. In addition, using purposive sampling, we conducted in-depth interviews with 22 women who delivered and 6 focus group discussions with 42 community leaders, traditional birth attendants, and Casas Maternas staff members. We analyzed the quantitative data using descriptive statstics and the qualitative data with descriptive content analysis. Results: Of the 321 women eligible for inclusion in the study, we surveyed 275 women (14.3% could not be located or refused to participate). Between April 2013 and March 2014, 70% of women living in partner communities delivered in a health facility (54% in a Casa Materna) compared with 30% of women living in non-partner communities (17% in a Casa Materna). There was no statistically significant difference in uptake of the Casa Materna by maternal education and only a weak effect by household wealth. In contrast, distance from the Casa Materna had a pronounced effect. Traditional birth attendants were strong advocates for utilization of the Casa Materna and played an important role in the

  4. Testando o Modelo da Casa da Capacidade para o Trabalho entre profissionais do setor hospitalar

    Directory of Open Access Journals (Sweden)

    Maria Carmen Martinez

    Full Text Available RESUMO: Objetivo: Testar o Modelo da Casa da Capacidade para o Trabalho, verificando a hierarquia das dimensões propostas para um grupo de trabalhadores do setor hospitalar. Métodos: Estudo de coorte (2009-2011 conduzido com 599 trabalhadores de um hospital na cidade de São Paulo. Foi usado um formulário com questões sobre dados sociodemográficos, estilo de vida e condições de trabalho, e as versões brasileiras da Escala Estresse no Trabalho, Desequilíbrio Esforço-Recompensa, Work-Related Activities That May Contribute To Job-Related Pain and/or Injury e Índice de Capacidade para o Trabalho (ICT. Foi realizada análise de regressão logística hierárquica: as variáveis independentes foram alocadas em níveis de acordo com as dimensões do modelo teórico para avaliar os fatores associados ao comprometimento da capacidade para o trabalho (CT. Resultados: As variáveis associadas ao comprometimento da CT em cada dimensão foram: (a dimensão sociodemográfica: idade < 30 anos (p = 0,20, (b dimensão saúde: história de acidente de trabalho (p = 0,029, (c dimensão competência profissional: baixo nível educacional (p = 0,008, (d dimensão valores: intensificação do excesso de comprometimento (< 0,001, e (e dimensão trabalho: intensificação do desequilíbrio esforço-recompensa (p = 0,009 e das demandas elevadas (p = 0,040. Conclusão: Os resultados do estudo confirmaram as dimensões propostas para o Modelo da Casa da Capacidade para o Trabalho, indicando que ele é válido como representação de um construto multidimensional de determinação multicausal, podendo ser utilizado na gestão da CT.

  5. El uso del hierro en la Casa Milá de Barcelona

    Directory of Open Access Journals (Sweden)

    Vila Rodríguez, Rafael

    1990-08-01

    Full Text Available The materials and construction systems, even the conception of the general structure, were for Gaudí no more than mediums at the service of the formal and spatial expression of his architectural imagination. Sometimes, the use of certain materials was indiscriminate or without sufficient guarantees. The Casa Milá is a good example. The use of laminated iron in the Pedrera, which allowed Gaudí to conceive a story independent of the façades —wall-screens of stone which seem to defy the law of gravity—, have been, at the same time, the main cause of the deterioration of these façades. In the case of the structure, the conceptual solution based on the use of iron has responded well to the static needs. This has not occured with the solutions —no less ingeneous but too improvlsed and risky— foreseen, also based on iron, to hold up the façade. Here, the material, subjected to the effects of humidity —favored by the form given to the stone—, has not resisted the passage of time very well.

    Los materiales y los sistemas constructivos, incluso la concepción de la estructura general, no eran para Gaudí más que medios al servicio de la expresividad formal y espacial de su imaginativa arquitectura. A veces, la utilización de algunos materiales se hizo de forma indiscriminada o sin suficientes garantías. La Casa Milá es un buen ejemplo. La utilización del hierro laminado en la Pedrera, que permitió a Gaudí concebir una planta libre independiente de las fachadas —muros-cortina de piedra que parecen desafiar la ley de la gravedad—, ha sido, al mismo tiempo, la causa principal del deterioro de estas fachadas. En el caso de la estructura, la solución conceptual basada en el uso del hierro ha respondido bien a las solicitudes estáticas. No ha ocurrido así con las soluciones —no menos ingeniosas pero excesivamente improvisadas y arriesgadas— previstas, también en base al hierro, para la sustentación de la fachada. Aqu

  6. Cuando dejan de ser bebés. una experiencia en la Casa Infantil Universitaria

    Directory of Open Access Journals (Sweden)

    González Corrales, Laura

    2007-04-01

    Full Text Available Resumen: En el presente artículo se realiza un análisis reflexivo acerca de los procesos experimentados por losniños y las niñas entre los dos y los tres años, en relación con los cambios continuos y progresivos en lasdiferentes áreas del desarrollo, a saber socioafectiva, cognitivo-lingüístico y psicomotriz. Asimismo, se da aconocer la experiencia obtenida como docentes de la Casa Infantil Universitaria de la Universidad de Costa Ricaen cuanto a las generalidades del desarrollo en esta edad. Las particularidades presentadas por la poblacióninfantil que asiste a la institución, así como las estrategias seguidas para su atención. Se hace referencia a laexperiencia lograda durante el período del II Ciclo 2005 y el I Ciclo 2006, el cual constituyó una excelenteoportunidad para favorecer el desarrollo integral de las personas de esas edades y el crecimiento profesional ypersonal de las maestras de la Casa Infantil Universitaria. Finalmente, se brindan algunas estrategias yconsideraciones finales sobre cómo conducir y guiar a los niños y las niñas de esta edad en ambientes noescolarizados.Abstract: The next article is intended to make a reflexive analysis about the procedures experimented by the littleboys and girls between ages two to five years old, related to the continuous and progressive changes in thedifferent areas of the development, such as the socio/affective area, the cognitive/linguistic area and thepsychomotor area. Therefore, it is set to cheer the experience obtained as teachers of the Children’s UniversityHouse from The Costa Rican University as far as the generalities of the development in these age range, theparticularities presented by the children that attend this institution, as well as the strategies that were followed totake care of this population. Is focused mainly to the experience achieved among the 2005 II semester and 2006 Isemester periods, that was an excellent opportunity to favor the integral

  7. Why nobody likes a prophet: Bartolomé de las Casas, a loud voice in the wilderness

    Directory of Open Access Journals (Sweden)

    Lawrence A. Clayton

    2016-12-01

    Full Text Available This essay focuses on and analyzes the role of prophet that Bartolomé de las Casas (1485–1566 lived out in the conquest and settlement of the New World. Borrowing a great deal from a shorter essay written years ago by Stafford Poole on the history and nature of prophets, we examine how Las Casas’s life mirrored so many of the qualities and characteristics of the prophet, especially those of the Old Testament. It is part of our general argument that one can only truly understand the life of Las Casas, often described as the greatest defender of American Indians (the “indigenous” in today’s jargon, by placing him squarely within the Scriptural prophetic tradition that drove both is thinking and his actions. This is a “Critical Essay” and it was originally delivered as a public lecture.

  8. Experimentando cuidados en el contexto de una casa de partos: visión de las pacientes

    OpenAIRE

    GONÇALVES, Roselane; AGUIAR, Cláudia de Azevedo; MERIGHI, Miriam Aparecida Barbosa; JESUS, Maria Cristina Pinto de

    2011-01-01

    O modelo de assistência ao parto e nascimento no Brasil tem sido tema de muitas discussões e estudos sobre a incorporação de práticas obstétricas que considerem a autonomia da mulher no processo de parturição. O modelo proposto pelas Casas de Parto configura-se como um cenário para esses cuidados. Este estudo voltou-se para a compreensão da vivência da mulher parturiente no contexto de uma Casa de Parto situada em São Paulo. Os dados foram coletados no período de março a outubro de 2007 e ana...

  9. Unicidade: Proposta para uma cidadania ativa no espaço urbano aumentado do bairro de Casa Amarela

    Directory of Open Access Journals (Sweden)

    Madyana Torres

    2015-10-01

    Full Text Available Urban public spaces reflect changes in socioeconomic and political structures of a population. Concepts such as Augmented City reveal how this space is currently being progressively transformed and measured, as well as the growth of its importance. Given this context, this study investigates how to stimulate the feeling of protection and familiarity and how the designer can handle the complexity of this scenario. To that end, a project was proposed for the Casa Amarela neighbourhood, in Recife. Focusing on how to stimulate the engagement of the current group of residents to the collective Casa Amarela Saudável e Sustentável, techniques of Participatory Design were used for research, ideation and project development.

  10. Minha casa, minha vida: extensão do direito à moradia e proteção constitucional

    OpenAIRE

    Guilherme Domingos de Luca; Teófilo Marcelo de Arêa Leão Júnior

    2016-01-01

    O trabalho em questão busca analisar o Direito à moradia sob a ótica do Programa “Minha Casa, Minha Vida”. Demonstrará as ações do Estado visando a Regularização Fundiária, em face do interesse social no combate ao déficit imobiliário, além de analisar as hipóteses de perda do imóvel. O objetivo geral do estudo é compreender se há efetividade no direito à moradia a partir da vinculação ao Programa “Minha Casa, Minha Vida”, instituído pelo advento da Lei n° 11.977/09. De forma específica, o ob...

  11. Fray Bartolomé de Las Casas in the Work and Thought of Fray Servando Teresa de Mier

    Directory of Open Access Journals (Sweden)

    Begoña Pulido Herráez

    2011-10-01

    Full Text Available This paper studies the presence and influence of fray Bartolomé de Las Casas’s thought on the work of fray Servando Teresa de Mier, particularly the way in which it influenced the shaping of his original idea of the existence of a pact, a set of fundamental laws, a constitution established in the years after the conquest and where America would be included in the Crown of Castile as an independent realm, and not a colony. We examine the different texts where Mier starts to appropriate Las Casas’s thought, especially two poorly known texts: the Speech of Doctor Don Servando de Mier, born in Mexico, confirming the apology of Bishop Casas, written by the Reverend Bishop of Blois, Monsignor Henrique Gregoire, in a letter written in the year 1806, and the prologue to the edition of A Short Account of the Destruction of the Indies by Bartolomé de las Casas.

  12. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population

    OpenAIRE

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-01-01

    ABSTRACT Background: An international NGO, with financial and managerial support from ?partner? communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala?an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access t...

  13. Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants.

    Science.gov (United States)

    Posner, Kelly; Oquendo, Maria A; Gould, Madelyn; Stanley, Barbara; Davies, Mark

    2007-07-01

    To evaluate the link between antidepressants and suicidal behavior and ideation (suicidality) in youth, adverse events from pediatric clinical trials were classified in order to identify suicidal events. The authors describe the Columbia Classification Algorithm for Suicide Assessment (C-CASA), a standardized suicidal rating system that provided data for the pediatric suicidal risk analysis of antidepressants conducted by the Food and Drug Administration (FDA). Adverse events (N=427) from 25 pediatric antidepressant clinical trials were systematically identified by pharmaceutical companies. Randomly assigned adverse events were evaluated by three of nine independent expert suicidologists using the Columbia classification algorithm. Reliability of the C-CASA ratings and agreement with pharmaceutical company classification were estimated. Twenty-six new, possibly suicidal events (behavior and ideation) that were not originally identified by pharmaceutical companies were identified in the C-CASA, and 12 events originally labeled as suicidal by pharmaceutical companies were eliminated, which resulted in a total of 38 discrepant ratings. For the specific label of "suicide attempt," a relatively low level of agreement was observed between the C-CASA and pharmaceutical company ratings, with the C-CASA reporting a 50% reduction in ratings. Thus, although the C-CASA resulted in the identification of more suicidal events overall, fewer events were classified as suicide attempts. Additionally, the C-CASA ratings were highly reliable (intraclass correlation coefficient [ICC]=0.89). Utilizing a methodical, anchored approach to categorizing suicidality provides an accurate and comprehensive identification of suicidal events. The FDA's audit of the C-CASA demonstrated excellent transportability of this approach. The Columbia algorithm was used to classify suicidal adverse events in the recent FDA adult antidepressant safety analyses and has also been mandated to be applied to all

  14. Estudo retrospectivo dos transplantes penetrantes de córnea da Santa Casa de Porto Alegre Retrospective study of penetrating keratoplasty at the Santa Casa of Porto Alegre

    Directory of Open Access Journals (Sweden)

    Caroline Fabris

    2001-10-01

    Full Text Available Objetivos: Traçar o perfil clínico e social dos pacientes submetidos a transplante de córnea e avaliar as principais indicações desses transplantes, tempo de espera para doação e os índices de sucesso, rejeição e falência dos transplantes penetrantes de córnea. Métodos: Foram analisados retrospectivamente os prontuários de 87 pacientes submetidos a transplante penetrante de córnea no Serviço de Oftalmologia da Santa Casa de Porto Alegre entre janeiro de 1990 e dezembro de 1998, totalizando 91 olhos. Destes, 56 pacientes foram chamados para avaliação clínica do enxerto durante o levantamento de dados para este estudo. Resultados: Considerando-se os 91 transplantes (87 pacientes, 53 (60,9% foram realizados em pacientes do sexo masculino e 34 (39%, do sexo feminino. A idade variou de 3 a 89 anos, com média de 42,3 ± 19,8 anos. As principais indicações para transplante de córnea foram ceratocone em 32 (35% olhos, ceratopatia bolhosa (pós-facectomia, distrofia de Fuchs e outros em 24 (26,4%, trauma mecânico em 9 (9,9%, causas infecciosas em 9 (9,9%, queimadura química em 2 (2,2%, queimadura térmica em 1 (1,1% e outras causas em 14 (15,4% olhos. O tempo médio de espera por doação de córnea foi de 17,3 ± 9,9 meses. Do total de 91 olhos transplantados, 25 (27,5% apresentaram rejeição e 12 (13,2% olhos apresentaram falência do transplante. Conclusões: Este estudo mostrou a epidemiologia dos pacientes transplantados. A falta de dados seriados devido à alta precoce e perda de acompanhamento dos pacientes tornou impossível a análise e a comparação dos resultados pós-operatórios com outros estudos.Purpose: To describe the clinical and social profile of recipient patients of transplanted corneas, and to evaluate main indications for corneal transplants, waiting time for donor tissue, and percentages of success, rejection and failure of penetrating keratoplasty. Methods: Retrospective chart review of 87 patients

  15. Relatório de Salvamento e Acompanhamento Arqueológico nas Obras de Restauro da Casa da Banha

    Directory of Open Access Journals (Sweden)

    Luciana Peixoto

    2012-09-01

    Full Text Available Este relatório  apresenta os resultados do trabalho de acompanhamento e salvamento arqueológico realizado pelo Instituto de Memória e Patrimônio em parceria com o Laboratório de Antropologia e Arqueologia da UFPEL no imóvel denominado Casa da Banha durante as obras de restauro executadas no ano de 2007. O imóvel localizado no entorno da Praça Coronel Pedro Osório, centro histórico de Pelotas, foi construído na década de 30 do século XIX e ao longo de sua história sediou diversas instituições, públicas e privadas, sendo conhecido até hoje pelo nome Casa da Banha, último estabelecimento comercial que ali se instalou na década de 60 do século XX.PALAVRAS-CHAVE: Arqueologia histórica, Patrimônio.ABSTRACT: This report presents results of the work Monitoring and Rescue Archaeological accomplished by Institute for Memory and Heritage in partnership with the Laboratory of Anthropology and Archaeology of UFPEL in the property called Casa da Banha the restoration  works carried out in 2007. The property located around of Praça Coronel Pedro Osório, the historic center of Pelotas, was built in the late 30th century Throughout its diverse history hosted institutions, public and private, being known today by the name  of the Casa da BAnha, last commercial establishment that settled there in the 60s of the XX Century.KEY-WORKS: Historical Archaeology, Heritage.

  16. Autoficción y trabajo de memoria en La casa de los conejos de Laura Alcoba

    Directory of Open Access Journals (Sweden)

    Bruno Ragazzi

    2014-02-01

    Full Text Available The article explores discursive representations within the field of memory in La casa de los conejos by Laura Alcoba. The choice of autofiction as a genre allows discovering new mnemic narratives around the unequal confrontation between Montoneros and right-wing repressive forces. These novel ways of viewing the past are connected to what Ricoeur has called “work of memory”, a therapeutic elaboration on memory that enables a community to reach hope and forgiveness.

  17. Content validity of CASA-Q cough domains and UCSD-SOBQ for use in patients with Idiopathic Pulmonary Fibrosis.

    Science.gov (United States)

    Gries, Katharine Suzanne; Esser, Dirk; Wiklund, Ingela

    2013-09-16

    The study objective was to assess the content validity of the Cough and Sputum Assessment Questionnaire (CASA-Q) cough domains and the UCSD Shortness of Breath Questionnaire (SOBQ) for use in patients with Idiopathic Pulmonary Fibrosis (IPF). Cross-sectional, qualitative study with cognitive interviews in patients with IPF. Study outcomes included relevance, comprehension of item meaning, understanding of the instructions, recall period, response options, and concept saturation. Interviews were conducted with 18 IPF patients. The mean age was 68.9 years (SD 11.9), 77.8% were male, and 88.9% were Caucasian. The intended meaning of the CASA-Q cough domain items was clearly understood by most of the participants (89-100%). All participants understood the CASA-Q instructions; the correct recall period was reported by 89% of the patients, and the response options were understood by 76%. The intended meaning of the UCSD-SOBQ items was relevant and clearly understood by all participants. Participants understood the instructions (83%) and all patients understood the response options (100%). The reported recall period varied based on the type of activity performed. No concepts were missing, suggesting that saturation was demonstrated for both measures. This study provides evidence for content validity for the CASA-Q cough domains and the UCSD-SOBQ for patients with IPF. Items of both questionnaires were understood and perceived as relevant to measure the key symptoms of IPF. The results of this study support the use of these instruments in IPF clinical trials as well as further studies of their psychometric properties.

  18. Trabajo y salud en la mujer: análisis comparativo de mujeres con trabajo remunerado y amas de casa

    Directory of Open Access Journals (Sweden)

    Mª E. ESCALERA IZQUIERDO

    2000-01-01

    Full Text Available El objetivo de este estudio es detectar y analizar las posibles diferencias en salud, tanto psicológica como física, en mujeres con roles múltiples y amas de casa en exclusiva. Todas ellas tenían hijas/os, pareja y bastantes, un trabajo remunerado. Además de las diferencias, se han estudiado otras variables con las que la salud pudiera estar relacionada como las condiciones de trabajo (tanto en el campo laboral como en el doméstico, familiares (afectivas y ayuda instrumental, la tensión entre roles y recursos (autoestima, conductas de salud y de riesgo, apoyo social, nivel educativo e ingresos. Los resultados mostraron que existía una gran diferencia en las variables que explicaban la salud de las mujeres según trabajasen o no fuera de casa y una tendencia hacia una mejor salud por parte de las mujeres con trabajo remunerado. Para ambos grupos las variables más relevantes para una mejor salud estuvieron relacionadas con las conductas de salud y de riesgo y la tensión entre roles. En las que trabajaban fuera de casa fueron muy significativas la autoestima y las variables relativas a sus roles familiares (relaciones con la pareja e hijos/as así como las condiciones del trabajo doméstico, por delante de las laborales.

  19. STUDY REGARDING THE PERFORMANCE EVOLUTION OF „CASA DE LA ROSA” HOTEL

    Directory of Open Access Journals (Sweden)

    PÎRJOL FLORENTINA

    2015-12-01

    Full Text Available The main goal of an economic activity in tourism is the granting of the effective needs and the potential needs of its consumers. The accomodations present a growing interest regarding the quality level of the services, the variety and also the complexity off additional services, so that the tourists have impecable conditions for the whole duration of their stay. The performance of a hotel, mainly results, from the impression the tourist leaves with. Therefore, if the offered services, aswell as the staff attitude pleased the tourist, he will return to that place. In the presented paper, the performance evolution of „Casa de la Rosa” Hotel was analysed. This is a 3 star hotel, from Timisoara, Timis county. The analysis was made for a period of 5 years from 2010 to 2014. For this purpose, I asked the hotel manager, Mr. Laurentiu ONEA, information regarding the „checking-in”, the medium stay, and the percentage of the foreign tourists as well as the Romanian tourists. This data was then used to calculate the indicators , required to the analisys. From a financialy-economical point of view analisys, data from the hotels internal sources were used regarding the turnover, profit and debts. The analisys showed a significant yearly growth of the hotels performances, mainly in the last 3 years of the analised period.

  20. CUIDANDO UN HIJO PREMATURO EN CASA: DEL TEMOR Y LA DUDA A LA CONFIANZA

    Directory of Open Access Journals (Sweden)

    Melva Patricia Ocampo González

    2014-01-01

    Full Text Available Ser madre es el resultado de un proceso que implica desarrollar una fuerte identidad maternal, este inicia en la gestación y abarca incluso los primeros meses de vida del hijo. Este proceso se nutre de la constante interacción madre-hijo. Para conocer las vivencias de las madres de niños prematuros que han requerido hospitalización, al asumir el cuidado de ellos en casa, se realizó un estudio fenomenológico con participación de diez madres. Los hallazgos indican que la separación de la diada durante la hospitalización impone limitaciones, que impiden que la mujer asuma con tranquilidad y alegría el nuevo rol. Es importante empoderar al personal de enfermería de las unidades neonatales para implementar estrategias de contacto temprano y continuo madre-hijo, que apoyen a las mujeres en el proceso de convertirse en madres.

  1. Casa de un arquitecto, en la Tour-de-Peilz (Suiza

    Directory of Open Access Journals (Sweden)

    Pythoud, René

    1966-09-01

    Full Text Available This building has two levels. One of them is a semibasement, which contains a bedroom, a playroom, a wash room, a wine celler, a laundry, a boiler room and a garage. The other level, above the ground, has a living room, a dining room, a kitchen, for bedrooms and services. The house has been very simply constructed, and is almost totally open to the surrounding landscape. Materials have been employed strictly for functional purposes. The interior furniture and decoration are also most simple and elegant.Esta construcción tiene dos niveles: uno, el de semisótano, que está ocupado por un dormitorio, cuarto de juegos, una ducha y W. C., bodega, lavadero, cuarto de calefacción y garaje; y otro, en nivel superior, que aloja la sala de estar, comedor, cocina, cuatro dormitorios y los servicios. La casa es de una gran sencillez constructiva, casi totalmente abierta al paisaje que la circunda, y en ella se han utilizado los materiales con noble y pura sinceridad. La decoración y mobiliario interior son, asimismo, sencillos y de una gran elegancia.

  2. Language’s Configurations in La casa de los conejos by Laura Alcoba

    Directory of Open Access Journals (Sweden)

    Estefanía Luján Di Meglio

    2018-01-01

    Full Text Available This article studies a novel written in the argentinean posdictatorship, in French, La casa de los conejos (2007 by Laura Alcoba. The main concept of the paper is the mother and second tongue and its multiples links with the history –the history of state violence– that novel relates. First of all, it is studied the fact that text is written in French in spite of author’s mother tongue is Spanish: Alcoba had to go into exile during the period of the “Triple A” in Argentina. In second place, it is observed that beyond this fact, there are several words written in Spanish. Such words work as metonymy of a whole language (Spanish, as a symbol of a history (the state terrorism and at the same time, they work as a metonymy of posdictatorship argentinean literature: those words represent the capital fact to telling a history in another way of that one of the oficial history.

  3. Simulation of Net Primary Productivity in Mongolia Using CASA Model, During 2000-2004

    Directory of Open Access Journals (Sweden)

    Narangarav Dugarsuren

    2016-12-01

    Full Text Available Vegetation net primary productivity (NPP is always used as an indicator of carbon cycling in terrestrial ecosystems at landscape and regional scales. Based on the CASA model, we analyzed the spatiotemporal pattern of growing season NPP from 2000 to 2004 using MODIS/NDVI and its relationship with precipitation. The result shows that the annual NPP in Mongolia has a tendency to slightly decrease from 61.13 in 2000 to 60 gC/m2 /yr in 2004, with an annual mean decrement of -0.259 gC/ m2 /yr. However, annual and inter-annual NPP trends showed spatial and temporal heterogeneity. NPP in forest and grassland has decreased with an average annual decrement of -1.03 (r2=0.262 and -0.49 (r2=0.324, meanwhile NPP in desert steppe and desert has increased with the annual average increment of 0.4327 (r2=0.322 and 0.2401 (r2=0.283, respectively. The correlation coeffi cient showed that mean growing season NPP in grassland and desert steppe were closely correlated with precipitation than forest and desert.

  4. "Eu quero uma casa no campo": a busca do verde em Belo Horizonte, 1966-1976

    Directory of Open Access Journals (Sweden)

    Regina Horta Duarte

    Full Text Available A expansão de condomínios horizontais esteve diretamente relacionada às condições históricas que acarretaram a deterioração e o abandono do centro urbano de Belo Horizonte, entre meados das décadas de 1960 e 1970. Nesse contexto, alguns tiveram o privilégio de escolher o sonho da casa no campo, atraídos por promessas de uma vida renovada, mergulhados nos paradoxos do desenvolvimento e dos dramas sociais, políticos e ambientais em curso no Brasil durante a ditadura civil-militar. Cientistas e técnicos realizavam as primeiras avaliações dos dilemas da poluição ambiental urbana. Entretanto, temas ambientais se configuravam como assunto extemporâneo e distante da política, subestimados por setores brasileiros de direita e esquerda. A perda de qualidade de vida em Belo Horizonte recebeu soluções individuais, por vezes com aspectos comunitários. O caráter simultâneo desses processos na capital mineira esclarece casos históricos similares em outras grandes metrópoles brasileiras e latino-americanas.

  5. Una finestra sul passato: Irse de casa di Carmen Martín Gaite

    Directory of Open Access Journals (Sweden)

    Giulia Tosolini

    2015-01-01

    Full Text Available Beyond historical and social implications, migration represents the possibility of crossing a threshold and opening oneself up to new empirical and emotional spaces. Amparo, the main character of Carmen Martín Gaite’s Irse de casa (1998, is the perfect personification of the gaitian feminine canon. After leaving Spain and settling in New York, she became a successful fashion designer, and seemed happy and easy-going. The bond with memory and the past is the main topic of this novel, as it is in most of Martín Gaite’s production. The window on the past that Amparo closed moving to the US suddenly reappears when she needs to discover herself and her origins. This inconvenience in an anonymous life brings huge changes that will condition her and her loved ones. Travelling to Spain and interacting with places and people connected with her childhood, Amparo goes through the window she had closed forty years before, restoring the order. The window connects the present and the past, symbolizes the emigrant’s transience, personified in the novel by Amparo, who can definitely find the lost serenity and heart’s-ease.

  6. Breath of fresh air; CASA's stakeholder approach has the glow of success

    International Nuclear Information System (INIS)

    Budd, G.

    2005-01-01

    The Clean Air Strategic Alliance (CASA), a stakeholder group of government, industry and officials from non-profit environmental groups, reports having achieved its target of 70 per cent reduction in flaring. The target was set in the late 1990s, and was reached in 2004. Environmentalists with public interest groups were particularly pleased, noting that methane, the main constituent of solution gas, is 23 times more potent in its greenhouse effect than carbon dioxide. Recent regulatory changes in sour gas management should reduce sulphur dioxide emissions as well, partly because a previous requirement for recovery of 96 per cent sulphur has been replaced by a 98.5 per cent sulphur recovery requirement. Despite these dramatic reductions in flaring, concerns continue to exist, as evidenced by a recent report about barriers that stand in the way of some further improvements, preventing upstream oil and gas companies from investing in emission-reducing and other environmental technologies. To reduce the barriers, the report advocates more and bigger tax incentives for environmental innovations, as well as direct funding during the demonstration phase of technology commercialization

  7. NEW HUMAN SEMEN ANALYSIS SYSTEM (CASA USING MICROSCOPIC IMAGE PROCESSING TECHNIQUES

    Directory of Open Access Journals (Sweden)

    N M Chaudhari

    2016-11-01

    Full Text Available Computer assisted semen analysis (CASA helps the pathologist or fertility specialist to evaluate the human semen. Detail analysis of spermatozoa like morphology and motility is very important in the process of intrauterine insemination (IUI or In-vitro fertilization (IVF in infertile couple. The main objective for this new semen analysis is to provide a low cost solution to the pathologist and gynecologist for the routine raw semen analysis, finding the concentration of the semen with dynamic background removal and classify the spermatozoa type (grade according to the motility and structural abnormality as per the WHO criteria. In this paper a new system , computer assisted semen analysis system is proposed in which hybrid approach is used to identify the moving object, scan line algorithm is applied for confirmation of the objects having tails, so that we can count the actual number of spermatozoa. For removal of background initially the dynamic background generation algorithm is proposed to create a background for background subtraction stage. The standard data set is created with 40× and 100× magnification from the different raw semen s. For testing the efficiency of proposed algorithm, same frames are applied to the existing algorithm. Another module of the system is focused on finding the motility and Type classification of individual spermatozoa.

  8. From Rhetoric to Interculturality. Some reflections on the contributions of Bartolomé de las Casas

    Directory of Open Access Journals (Sweden)

    Lorena Zuchel

    2018-01-01

    Full Text Available Writing in favor of the rhetoric, Las Casas was actually searching for a new anthropological model that would be different both from the elite humanism and from the Erasmian voluntarism. We would like to emphasize this attitude in the light of Las Casas’ practical objectives, which is to prevent from further homicide and to guarantee an unconditioned freedom to the Indians in every aspect of their social life. We will refer to this revolutionary attitude which is based on the theories of Aristotle and St. Thomas, but is also capable of overshadowing them in defense of the humanity itself and human values. The most important point of Las Casas’ theory is the recognition of the right and ability of every community to have an autonomous way of governing. For that reason, we argue, his writings can be interpreted as an important contribution to the question of the recognition of the Other, and as the theoretical starting point for the intercultural philosophy as well.

  9. San Pedro Atlapulco and the Real Casa de Moneda: Vicissitudes of a Community Enterprise

    Directory of Open Access Journals (Sweden)

    Felipe Castro Gutiérrez

    2008-01-01

    Full Text Available This work suggests the existence of very interesting exceptions to the widespread idea that New Spain indians were farmers who produced basically for their own needs and for paying tribute, thus limiting their contacts with the market. The author  examines the case of Atlapulco, a town that very soon became the main provider of charcoal as fuel for the official mint, the Real Casa de Moneda in Mexico City. The research reveals Atlapulco’s constant  battle against the arrival of indian and Spanish competitors seeking a sha­re in the deal, suggesting that the main reason for this attitude was the preservation of a lucrative monopoly, considered a special pri­vilege granted by the king. The author also describes the disputes between Atlapulco  and the mint administrators over fixing con­ tractually the price of charcoal. Finally, he examines the discourse used by Indians in the defense of their interests, pointing out how they appealed to the idea that commercial arrangements must ne­cessarilly take into account tradition, historical rights and mutual obligations sustaining social order.

  10. Trabalho de casa, auto-eficácia e rendimento em matemática

    Directory of Open Access Journals (Sweden)

    Pedro Sales Luís Rosário

    Full Text Available O Trabalho de Casa (TPC é uma estratégia instrutiva amplamente utilizada na Escola de muitos países. O TPC é um processo complexo que é afectado por múltiplos factores de ordem cognitiva, motivacional, social e contextual. A investigação tem-se centrado no tempo despendido na realização das tarefas de TPC, no entanto os resultados de vários estudos e as críticas metodológicas sugerem a necessidade de direccionar a pesquisa para outras variáveis. O objectivo deste estudo é a análise do poder preditivo da auto-eficácia percebida na Matemática e de três dimensões menos exploradas na literatura do TPC (e.g., número de TPC prescritos, taxa de completamento, e correcção percebida do TPC sobre o rendimento a matemática, em alunos portugueses do 5.º e 6.º ano de escolaridade (10 e 11 anos. Os resultados sugerem que o rendimento a matemática se encontra explicado, positiva e significativamente, pelas variáveis escolhidas. As conclusões sugerem a urgência de repensar o TPC como ferramenta educativa promotora do sucesso académico.

  11. Histórias de vida: as parteiras tradicionais e o nascimento em casa

    Directory of Open Access Journals (Sweden)

    Maria Djair Dias

    2007-08-01

    Full Text Available Esta é uma pesquisa qualitativa que utilizou a História Oral como caminho para investigar o fenômeno do nascimento em casa. Trata-se de compreender o significado da experiência de cuidar da mulher durante o processo de nascimento em domicilio em uma comunidade rural nordestina, a partir da história oral de vida das parteiras tradicionais. Os resultados revelam que a história de vida dessas mulheres se inscreve em um saber milenar que ao longo do tempo oferece significativa contribuição para a construção de um novo olhar em busca da humanização das relações no contexto da saúde, embora muito desse saber tenha sido desconsiderado com a institucionalização do cuidado. Diante da diversidade do universo cultural que envolve esse saber, considerado uma prática de solidariedade, um dom de Deus, conhecer e respeitar é condição fundamental para uma aproximação real entre o saber popular e o saber cientifico.

  12. Avaliação de critérios para calagem de arroz inundado em casa de vegetação

    Directory of Open Access Journals (Sweden)

    M. Borges Júnior

    1998-06-01

    Full Text Available O presente trabalho foi desenvolvido, no período de maio a setembro de 1995, com o objetivo de avaliar critérios para a recomendação de calcário para o arroz em solos inundados de Minas Gerais. Foram avaliados os efeitos de doses crescentes de carbonatos de cálcio e de magnésio sobre a produção de matéria seca de plantas de arroz em casa de vegetação. O experimento constou de um fatorial completo com dez solos de várzeas e cinco níveis de calagem. Verificou-se que a acidez potencial (H + Al a pH 7,0, a saturação por bases (V, o teor de carbono orgânico (C e o teor de cálcio mais magnésio (Ca + Mg foram as características dos solos que mais influenciaram as doses recomendáveis de calcário. Por outro lado, os teores de Fe e de Mn redutíveis do solo não tiveram influência significativa na recomendação de calagem. O método que visa elevar V a 40% foi mais eficiente na definição das doses recomendáveis para obtenção da matéria seca equivalente a 90% da máxima eficiência física.

  13. Ca isotopes in refractory inclusions

    International Nuclear Information System (INIS)

    Niederer, F.R.; Papanastassiou, D.A.

    1984-01-01

    We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

  14. Casas e portas da memória e do patrimônio

    Directory of Open Access Journals (Sweden)

    Mario Chagas

    2007-12-01

    Full Text Available Apresenta reflexões em torno do conceito de patrimônio, desde a sua origem até a contemporaneidade. Afirma que existe uma relação intrínseca entre patrimônio e poder, que permanece na relação entre patrimônio e propriedade, seja material ou espiritual, econômica ou simbólica e a sua vinculação à idéia de preservação. Destaca que a noção de posse parece ser mais adequada aos museus do que a de propriedade Sugere que o caráter preservacionista e o sentido de posse estão na raiz da instituição do patrimônio e do museu (casa de memória e poder. Ressalta que a preservação como prática social que é utilizada para a construção de determinadas narrativas tem um caráter subjetivo, que é mascarado por discursos que se pretendem positivos, científicos e objetivos. Conclui que o que está em jogo nos museus e também no domínio do patrimônio cultural é memória, esquecimento, resistência e poder, perigo e valor, múltiplos significados e funções, silêncio e fala, destruição e preservação. E por tudo isso interessa compreendê-los em sua dinâmica social e interessa compreender o que se pode fazer com eles, contra eles, apesar e a partir deles.

  15. Varicella at "Casa Garrahan", 2008-2013: Assessment of postexposure prophylaxis measures.

    Science.gov (United States)

    Ruvinsky, Silvina; Taicz, Moira; Pérez, M Guadalupe; Mónaco, Andrea; García Escudé, Natalia; Inda, Laura; Carbonaro, Mirta; Bologna, Rosa

    2015-06-01

    Casa Garrahan (CG) accommodates children with complex conditions referred nationwide; these children are seen in children's hospitals located in the Autonomous City of Buenos Aires. Varicella is a highly-contagious disease, with attack rates of up to 90% among susceptible individuals. In closed communities, the implementation of outbreak control measures is critical. To describe the characteristics of children exposed to varicella at CG, the implemented prophylaxis measures and their effectiveness. Prospective, cohort study. Children exposed to varicella at CG between2008 and 2013, their demographic and clinical characteristics, immunization and/or history of varicella, prophylaxis measures, and secondary attack rate were assessed. N: 107. Fifty-three percent (n: 57) were girls. Their median age was 84 months old [interquartile range (IQR): 24-144]. Ninety-five percent (n: 102) had an underlying disease [hemato-oncological disease: 39% (n: 42); neurological disease: 18% (n: 19); congenital heart disease: 9% (n: 10); and post-operative period: 65 (n: 6)]. Fifty percent had some degree of immunosuppression (n: 54). Twenty-nine percent (n: 31) referred to have had varicella; 27% (n: 29) indicated that they never had the infection; and 41% (n: 44) did not recall a history of varicella. Only 3% (n: 3) had been vaccinated. Based on their immune status, age and history of varicella, acyclovir was indicated as prophylaxis in 61% (n: 65); immunization in 10% (n: 10); and gamma globulin in 1 patient. No adverse effects were observed in relation to the different prophylaxis measures. No secondary cases were observed at 30 days. Implemented measures were effective to prevent secondary cases. Among healthy and immunocompromised children, prophylaxis with acyclovir was effective and well-tolerated.

  16. Casas estudio: alternativa pedagógica para el proyecto de fin de carrera

    Directory of Open Access Journals (Sweden)

    Edison Henao Carvajal

    2011-12-01

    Full Text Available Este artículo da cuenta del proceso de elaboración del trabajo de grado de algunos de los estudiantes inscritos en la Línea de Profundización en Proyectos Arquitectónicos, del programa curricular de Arquitectura, de la sede Manizales de la Universidad Nacional de Colombia, durante los semestres segundo del 2009 y primero del 2010. El propósito de la experiencia, coordinada por los autores del artículo, consistió en poner a prueba un método de enseñanza-aprendizaje para el taller de proyectos de fin de carrera, en el marco de una concepción pedagógica basada en la solución de problemas de forma, a partir del reconocimiento y de la asimilación de las soluciones universales presentes en las obras de los grandes maestros de la arquitectura. En contravía de la metodología de concepción arquitectónica contemporánea, basada en “la realización de las ideas del autor”, el taller se centró en recuperar las maneras de operar de la modernidad arquitectónica, en las que tiene mayor importancia la búsqueda de una implantación correcta de la obra, la solución de los requerimientos programáticos del proyecto, su concepción constructiva y el planteamiento consistente de los espacios requeridos, en este caso, para una casa-estudio.

  17. Sin trabajo y sin casa: Subjetividades de la exclusión social

    Directory of Open Access Journals (Sweden)

    María Andrea Benítez

    2009-12-01

    Full Text Available Este estudio aborda la problemática de la exclusión laboral y habitacional, considerando que para quienes las padecen, la exclusión del trabajo (en términos de empleo y de condiciones dignas de habitación, implica una condición estigmatizante y deshonrosa que se desea abandonar, pero paradójicamente, visibilizar esta condición, puede constituir un paso para la superación de la misma, a través de la obtención de planes laborales o de asistencia habitacional. De esta forma se constituye una tensión que estructura los procesos de subjetivación y en consecuencia los modos de socialización de quienes atraviesan situaciones de exclusión del hábitat y el trabajo. Este trabajo se realizó sobre la base de entrevistas en profundidad a informantes que han vivido carencias de casa y trabajo. En ellas se privilegió la narración de las vivencias y definiciones propias de los actores.This study is focused on non - inclusion problematic related to labor and housing contexts. It considers a main paradox: the persons who are affected by non-inclusion situations because they have not granted minimum conditions of full employment and decent habitation, feel that those situations are stigmatizing and shameful. But in order overcome this non-inclusion condition -by obtaining employment plans or housing assistance- they have to make it visible. In this scenery emerges a conflict that configures subjectivity constitution and socialization processes. The study was based on opened interviews developed to a group of subject who have experienced a lack of home and work. The interviews emphasized subjective narrative of actors' experiences.

  18. Notas sobre la casa de los obispos de Córdoba en la Edad Media

    Directory of Open Access Journals (Sweden)

    Iluminado Sanz Sancho

    2005-01-01

    Full Text Available El estudio de la Casa y Corte de los Reyes ha supuesto una serie de novedades y avances importantes en la historiografía europea y española, que se ha aplicado también a algunos estados nobiliarios. Pero, hasta el momento, esta problemática y su estudio no se han proyectado sobre los altos eclesiásticos y menos aún en los tiempos medievales. Él presente artículo, reconociendo la dificultad que conlleva la carencia de fuentes suficientes, pretende, no obstante, plantear la posibilidad de este tipo de estudios en la Historia de la Iglesia y un procedimiento oportuno para su tratamiento. Igualmente, presentar algunos datos y noticias concretas, pertenecientes a la Iglesia de Córdoba, que pueden avalar el interés de este estudio y aventurar un mejor conocimiento de la Historia en la Edad Media.The study of the Royal House and Court has meant a series of important newness and advances in the European and Spanish historiography, and has also been applied to some noble estafes. Although, so far, the study of this subject has not been projected over the upper Ecclesiastics and even less during the Middie Ages. The present article, admitting the difficulty of not having enough sources, attempts, nonetheless, to introduce the possibility of this type of studies in the history of the Church and an appropriate method for its study. It also tries to show some specific data and news belonging to the Church of Córdoba, all of it may guarantee the interest of this study and foretaste a better knowledge of the History during the Middie Ages.

  19. A Tarefa de Casa na Inclusão Escolar: Alunos com Deficiencia Física

    Directory of Open Access Journals (Sweden)

    Carolina Cangemi GREGORUTTI

    Full Text Available RESUMO: a tarefa de casa (TC pode contribuir para a realização de aprendizagem significativa e para complementar e reforçar as atividades realizadas em sala de aula. Objetivou-se identificar e analisar como as TC estão sendo propostas para alunos com deficiência física (DF inseridos em classes de ensino comum, a partir da percepção de professoras e cuidadoras familiares. Participaram do estudo 15 professoras e 15 cuidadoras familiares de crianças com DF, inseridas em classes de ensino comum. Para a coleta de dados foram utilizados dois roteiros de entrevista semiestruturados, sendo um aplicado para as professoras e outro para as cuidadoras familiares. As verbalizações foram gravadas e transcritas na íntegra para posterior análise de conteúdo e categorização. Os resultados sugerem que o professor, em muitos casos, não adapta as TC para atender as demandas do aluno e, em outros, não oferece tarefa para o aluno com DF na mesma proporção que o faz para os demais alunos. Com relação às famílias, os resultados indicam que estas percebem as dificuldades da criança e, ao mesmo tempo, angustiam-se com a falta de comunicação com a escola nesse quesito, o que ocasiona questionamentos e dúvidas em relação ao desempenho do aluno. Os resultados deste estudo podem ser úteis no contexto da Educação Inclusiva, no sentido de a TC adquirir uma função particularmente interessante, pois, se bem gerenciada, pode funcionar como uma atividade mediadora da interlocução entre a escola e a família.

  20. Da casa ao hotel: entre a hospitalidade e a economia do turismo

    Directory of Open Access Journals (Sweden)

    Felipe José Comunello

    2015-01-01

    Full Text Available O município de São Joaquim, na região serrana de Santa Catarina, tem sido destacado pela imprensa escrita e televisiva nacional como a cidade mais fria do Brasil, ao longo dos últimos vinte anos. Em pesquisa realizada para tese de doutorado, identifiquei que muitas proprietárias de pousadas, as “pousadeiras” como elas mesmas se chamam, começaram abrigando turistas em dificuldades em dias de frio intenso, quando não há hotéis e pousadas suficientes na cidade. A partir disso, elas acreditaram ser possível transformar suas casas em pousadas, tendo diante de si um problema também compartilhado com os profissionais do turismo, a chamada sazonalidade dos turistas. Tal fato provoca dúvidas sobre a sustentação econômica das pousadas e inquietação aos profissionais quanto ao sucesso econômico do turismo. Nesse artigo, isso é analisado tendo como referência uma proposta de parceria recebida por meus interlocutores por parte da operadora de turismo CVC e da empresa de eventos da RBS, afiliada da Rede Globo em Santa Catarina. A discussão é em torno de questões a partir de uma antropologia da hospitalidade. A análise sugere que essa parceria ameaça uma ordem moral estabelecida com base em determinados valores de hospitalidade para com estranhos, principalmente o aquecimento perante o frio.

  1. Discourse and Practice of Violence in the Italian Extreme Right: Frames, Symbols, and Identity-Building in CasaPound Italia

    Directory of Open Access Journals (Sweden)

    Pietro Castelli Gattinara

    2014-09-01

    Full Text Available An investigation of the neo-Fascist organization CasaPound Italia, focusing on how political violence is framed in its public discourse, and on the role it plays as a constitutive element of the group’s collective identity. Starting from the conceptualization of violence in Italian Fascism, we focus on CasaPound’s practices, discourse, and ideology. The analysis combines findings from nineteen in-depth interviews with CasaPound members and participant observation at protest events and activities. This paper disentangles CasaPound’s relationship with political violence, differentiating its discursive, aesthetic, and identity-building dimensions. Although in the external discourse of the group, violent activities are only accepted as a tool of self-determination and self-defence, we find that a cult of violence inspired by traditional Fascism emerges from the semiotic repertoire mobilized by CasaPound, and is reiterated by means of experiences of collective socialization based on violence.

  2. Contribution of the CASA system, based on open source software, to the assessment of sperm characteristics: informetric and usage-based approaches

    Directory of Open Access Journals (Sweden)

    Giovano Neumann

    Full Text Available ABSTRACT By using informetric tools, we evaluated the contribution and impact of the open source computer-assisted sperm analysis (CASA software on sperm studies, especially pertaining to fish. The article was cited 125 times between 2007 and 2014 in four publication types (articles, doctoral dissertations, master’s theses, and books. Among articles, the number of citations increased at rate of three citations per year and the calculated h-index was 17. Of the studies that cited Wilson-Leedy and Ingermann (2007, fish were the main group of organisms studied (61 articles; of these, 34 articles used the open source CASA, covering 23 marine or freshwater species. Studies conducted in 12 countries were published in 21 journals. Four ways of knowledge sharing were identified: by direct partnership with the system developers; by knowledge multipliers, who worked directly with the system developers; by groups that adopted the system by their own initiative; and through expansion of cooperation networks with autodidacts. In regard to specific analytical procedures, motility, curvilinear velocity, average path velocity, and straight-line velocity were the main CASA parameters used to describe sperm movements. As expected, the usage of this tool has been increasing over the years, being a reliable and versatile alternative to more costly similar platforms. However, the potential of the CASA system has not been completely explored and it is our assessment that some results produced by CASA are poorly understood or even misunderstood.

  3. Appraisal and standardization of curvilinear velocity (VCL) cut-off values for CASA analysis of Japanese quail (Coturnix japonica) sperm.

    Science.gov (United States)

    Farooq, U; Malecki, I A; Mahmood, M; Martin, G B

    2017-06-01

    One of the basic steps in objective analysis of sperm motility is the subdivision of a motile sperm population into slow, medium and rapid categories based on their velocity. However, for CASA analysis of quail sperm, the velocity values for categorization of slow, medium and rapid sperm have not yet been standardized. To identify the cut-off values of "velocity curvilinear" (VCL) for quail sperm categorization, we captured and analysed 22,300 tracks of quail sperm using SCA ® -CASA. The median and mean VCL values were 85 and 97 μm/s. To define the VCL cut-off values, we used two methods. In the first, we identified the upper (rapid sperm) and lower (slow sperm) cut-off values using: (i) median VCL ± 25% or ± 50% or ± 75% of median VCL value; (ii) first and third quartile values of VCL data (i.e. 25% cut-off setting); and (iii) 33% and 66% of VCL data. Among these settings, sperm categories and their corresponding motility characteristics recorded using the "25%" setting (i.e. slow ≤36 ≤ medium ≤154 ≤ rapid) were found the most realistic and coherent with male ranking by fertility. In the second method, we calculated heteroscedasticity in the total VCL data using PCA and the two-step clustering method. With this approach, the mean of the high and low clusters was 165 and 51 μm/s, respectively. Together, the mean from two methods suggested that, for SCA ® -CASA categorization of quail sperm, sperm should be classed as "rapid" at VCL ≥160 μm/s and "slow" at VCL ≤45 μm/s. © 2017 Blackwell Verlag GmbH.

  4. Monitoring ground-surface heating during expansion of the Casa Diablo production well field at Mammoth Lakes, California

    Science.gov (United States)

    Bergfeld, D.; Vaughan, R. Greg; Evans, William C.; Olsen, Eric

    2015-01-01

    The Long Valley hydrothermal system supports geothermal power production from 3 binary plants (Casa Diablo) near the town of Mammoth Lakes, California. Development and growth of thermal ground at sites west of Casa Diablo have created concerns over planned expansion of a new well field and the associated increases in geothermal fluid production. To ensure that all areas of ground heating are identified prior to new geothermal development, we obtained high-resolution aerial thermal infrared imagery across the region. The imagery covers the existing and proposed well fields and part of the town of Mammoth Lakes. Imagery results from a predawn flight on Oct. 9, 2014 readily identified the Shady Rest thermal area (SRST), one of two large areas of ground heating west of Casa Diablo, as well as other known thermal areas smaller in size. Maximum surface temperatures at 3 thermal areas were 26–28 °C. Numerous small areas with ground temperatures >16 °C were also identified and slated for field investigations in summer 2015. Some thermal anomalies in the town of Mammoth Lakes clearly reflect human activity.Previously established projects to monitor impacts from geothermal power production include yearly surveys of soil temperatures and diffuse CO2 emissions at SRST, and less regular surveys to collect samples from fumaroles and gas vents across the region. Soil temperatures at 20 cm depth at SRST are well correlated with diffuse CO2 flux, and both parameters show little variation during the 2011–14 field surveys. Maximum temperatures were between 55–67 °C and associated CO2 discharge was around 12–18 tonnes per day. The carbon isotope composition of CO2 is fairly uniform across the area ranging between –3.7 to –4.4 ‰. The gas composition of the Shady Rest fumarole however has varied with time, and H2S concentrations in the gas have been increasing since 2009.

  5. Don Alonso de Granada Venegas Rengifo, cuarto señor de la casa de Granada (1540-1611)

    OpenAIRE

    García Luján, José Antonio

    2014-01-01

    Limitada es la información que poseíamos hasta ahora sobre este conspicuo personaje. Sin embargo, un conjunto documental, disperso en varios archivos, ha posibilitado la realización de este artículo en el que se traza la biografía, hasta donde los documentos permiten, del que fuera titular de los mayorazgos y Casa de Granada desde 1565 hasta su fallecimiento en 1611. Sin duda, es su intervención en la rebelión morisca lo más conocido, que ahora se completa, al tiempo que se perfil...

  6. CASAS COMERCIALES Y SUS OPERACIONES EN VALPARAÍSO: El Caso del Carbón Extranjero. 1890-1905

    Directory of Open Access Journals (Sweden)

    Aldo Meneses Inostroza

    2017-04-01

    Full Text Available Chile posterior a la Guerra del Pacifico, vio incrementada fuertemente su actividad económica, con la integración del salitre, teniendo como principal combustible el carbón. De ahí que resulte importante conocer esta actividad donde se aprovisionó principalmente de hullas australianas e inglesas, permitiendo a su vez vislumbrar la mentalidad de quienes llevaron a cabo esta actividad, las casas comerciales involucradas, sus prácticas en lo relacionado a las ventas, bandas de precio de las hullas y formas de pago

  7. Minha Casa, Minha Vida Program: Public Policy Social (ExInclusion of the Population In Street Situation

    Directory of Open Access Journals (Sweden)

    Domingos do Nascimento Nonato

    2016-12-01

    Full Text Available The objective is to reflect the requirements used by the program Minha Casa, Minha Vida to select beneficiaries with housing units have correspondence with socioeconomic vulnerability experienced by people in the streets. We chose methodologically the bibliographical and documentary research, which was fundamental to deepen reflections on the object and the proposed objective. It was concluded that such requirements do not correlate with the degree of misery to that experienced by population segment, which is excluded from this housing public policy, and has subtracted by the Government itself the possibility of exercising the fundamental right to housing.

  8. Direito a moradia e inclusão social: aspectos positivos e negativos do "programa minha casa minha vida"

    OpenAIRE

    Desordi, Jordana Laís; Strücker, Bianca

    2016-01-01

    O presente artigo pretende analisar aspectos conceituais e doutrinários referentes ao direito à moradia e à inclusão social, fazendo referência aos aspectos positivos e negativos do programa habitacional brasileiro “Minha Casa Minha Vida” (PMCMV). A pesquisa dá ênfase ao PMCMV, momento em que é analisada a legislação que cria e institui o Programa em suas duas versões existentes até este momento. Destaca-se, ainda, os reflexos que o programa causou ao proporcionar o acesso do indivíduo a sua ...

  9. [Trends and perspectives of nursing administration: a study in the Santa Casa hospital of Belo Horizonte-MG].

    Science.gov (United States)

    Spagnol, Carla Aparecida; Ferraz, Clarice Aparecida

    2002-01-01

    The "Santa Casa" Hospital of Belo Horizonte has implemented a new management system that has characterized it as a flexible organization. Based on this context, the authors of this research defined the following objectives: to analyze nursing administration by considering the implementation of the Management System (SIGESC), to describe how the nursing team perceives communication, the decision-making process and interpersonal relationships, to identify possible trends and perspectives present in the administrative practice developed. A time of transition in nursing administration that presents characteristics of classical management and contemporaneous management was shown as well as trends and perspectives that will contribute to the reorganization of nursing work in hospitals.

  10. Frecuencia de comidas fuera de casa y calidad de hidratos de carbono y de grasas en el proyecto SUN

    OpenAIRE

    Villacis, C. (Cecilia); Zazpe, I. (Itziar); Santiago, S. (Susana); Fuente-Arrillaga, C. (Carmen) de la; Bes-Rastrollo, M. (Maira); Martinez-Gonzalez, M.A. (Miguel Ángel)

    2015-01-01

    Objetivo: Investigar la asociación entre la frecuencia de comidas fuera de casa (CFC) con a) la calidad de hidratos de carbono y b) la calidad de grasas. Materiales y métodos: Se evaluaron 19.371 participantes de la cohorte SUN que completaron un cuestionario basal de frecuencia de consumo de alimentos previamente validado. Se utilizaron los índices de calidad de hidratos de carbono (ICHC) en una escala de 4 a 20 y de grasas (ICG) en una escala de 0,62 a 5,92. En ambos...

  11. La memoria y el registro de la Real Hacienda de Indias en la Casa de la Contratación (The memory and the record of the Royal Treasury in Indies in the Casa de la Contratación

    Directory of Open Access Journals (Sweden)

    Francisco Fernández López

    2015-03-01

    Full Text Available Resumen: Este artículo presenta, desde una perspectiva metodológica diplomática, la descripción y análisis de los libros de contabilidad que se llevaron en la Casa de la Contratación para el control administrativo y contable de la Real Hacienda. A estos efectos, mi objetivo es establecer el origen, naturaleza, formas y evolución, así como una clasificación de estos libros. Para el registro de las operaciones contables en esta institución se utilizaron, desde el momento de su creación en 1503, los libros de cargo y data. A mediados del siglo XVI aparecieron, además, los libros de arcas y los diarios y mayores de la partida doble.Abstract: This paper present, from a diplomatic methodological perspective, a description and analysis the accounting books of the Casa de la Contratación to the administrative and accounting control of the Royal Treasury in Indies. To this purpose, it is possible to demonstrate the origin, nature, formals requirements and evolution, together with a classification of these books. Transactions were recorded in the charge and discharge books, since 1503, and since the mid-sixteenth century in the books about arks and in the journals and the ledgers for double-entry bookkeeping.

  12. [Santa Casa de Misericórdia and hygienist policies in Belém do Pará in the late nineteenth century].

    Science.gov (United States)

    Miranda, Cybelle Salvador; Beltrão, Jane Felipe; Henrique, Márcio Couto; Bessa, Brena Tavares

    2015-01-01

    The article analyzes the relationship between hygienist policies in effect in Belém in the late nineteenth century and the expansion of activities of the Santa Casa de Misericórdia do Pará. Considered one of the first hospital institutions in the former Grão-Pará Province, in addition to its own hospital, the Brotherhood administered several other health facilities in the capital, and the study of its physical displacement made it possible to "map" three health centers in Belém: Pioneer, Expansion and the Santa Casa, which reinforce the growth vectors of the city. The expansion of its activities is configured as the expansion of the Santa Casa de Misericórdia to serve the underprivileged and sick, preceding the establishment of a public health system in Pará.

  13. El fresco de la casa de Iulia Felix : anatomía de una scho

    Directory of Open Access Journals (Sweden)

    Milagros Moro Ipola

    2010-01-01

    Full Text Available Antes del contacto de Roma con las ciudades griegas del sur de Italia durante la Guerra contra Pirro en el siglo III a.C., el tipo de educación que recibían los jóvenes romanos era el reflejo de la sociedad agraria que era por entonces Roma. Los hijos estaban bajo la tutela de la madre o del aya hasta los siete años, aproximadamente, cuando el padre se hacía cargo de su formación. La relación con Grecia y su cultura revolucionó el sistema educativo tradicional y la enseñanza casera y honorable, como decía Plutarco (Quest. Rom. LIX pues «la gente enseñaba sólo a sus amigos y familiares», a cargo del paterfamilias dejó paso a una otra peor valorada impartida por maestros y profesores. El conocido fresco escolar encontrado en la casa de Iulia Felix en Pomeya nos sirve de guía para descubrir ese mundo a través de una imagen.Before the contact with the Greek cities in southern Italy during the war against Pyrrhus in the IIIrd century b.C., the young Romans had a kind of upbringing that was a reflection of the agrarian society Rome was at that time. Children were a guard of the mother or the governess until they were around seven. Then, the father took charge of their training. The relationship with Greece and its culture revolutionized the traditional education system and the home and honorable upbringing in the charge of the paterfamilias, as Plutarch said, (Quest. Rom. LIX because «people only taught the friends and the relatives», gave way to another one, given by teachers and not valued by society at all. The known school fresco found in the House of Iulia Felix, in Pompeii, can serve a guide in order to discover this world through an image.

  14. Encontros musicais como recurso em cuidados paliativos oncológicos a usuários de casas de apoio

    Directory of Open Access Journals (Sweden)

    Vladimir Araujo da Silva

    2013-06-01

    Full Text Available Investigação fenomenológica, estruturada na analítica existencial de Heidegger, que objetivou desvelar a percepção de usuários que vivenciam o câncer em uma casa de apoio, em relação aos encontros musicais. Participaram do estudo sete usuários da casa de apoio da Rede Feminina de Combate ao Câncer de Maringá, onde foram realizados oito encontros musicais, durante os meses de janeiro e fevereiro de 2011. Para a coleta de dados foi utilizada a entrevista individual, conduzida pela seguinte questão norteadora: o que esses encontros musicais representam para você neste momento de sua vida? Durante o processo de compreensão do fenômeno investigado, emergiram duas temáticas ontológicas - Sentindo-se cuidado nos encontros musicais e Transcendendo sua facticidade existencial. Constatou-se que o encontro mediado pela música constitui um recurso no cuidado de enfermagem em cuidados paliativos oncológicos, que inspira vida aos dias dos usuários, imprimindo-lhes a sensação de cuidado e ressignificando seu existir-no-mundo.

  15. Using African languages for democracy and lifelong learning in Africa: A post-2015 challenge and the work of CASAS

    Science.gov (United States)

    Brock-Utne, Birgit; Mercer, Malcolm

    2014-12-01

    Africans speak African languages in their everyday lives while lessons in school are delivered in an exogenous language. In many places adult education is also carried out in a language the majority of people do not speak. The exogenous languages, which are the languages of the former colonial powers and mastered just by a small African elite, are used in most parliaments in Africa and in most newspapers. This problem is largely ignored by the international community. An argument often put forward against using African languages as Languages of Instruction (LOIs) is that there are so many of them, and it may be problematic to select one as an LOI. But is this really the case? And does one need to select one language? The main work of the Centre for Advanced Studies of African Society (CASAS) located in Cape Town has been to harmonise the written forms of most African languages so that these languages can be used as LOIs and as languages of government and the press. This paper examines in some detail the work undertaken by CASAS, its successes and challenges. It shows that the political process of getting the harmonised languages adopted is more difficult and unpredictable than the linguistic work itself.

  16. Validation of the sperm class analyser CASA system for sperm counting in a busy diagnostic semen analysis laboratory.

    Science.gov (United States)

    Dearing, Chey G; Kilburn, Sally; Lindsay, Kevin S

    2014-03-01

    Sperm counts have been linked to several fertility outcomes making them an essential parameter of semen analysis. It has become increasingly recognised that Computer-Assisted Semen Analysis (CASA) provides improved precision over manual methods but that systems are seldom validated robustly for use. The objective of this study was to gather the evidence to validate or reject the Sperm Class Analyser (SCA) as a tool for routine sperm counting in a busy laboratory setting. The criteria examined were comparison with the Improved Neubauer and Leja 20-μm chambers, within and between field precision, sperm concentration linearity from a stock diluted in semen and media, accuracy against internal and external quality material, assessment of uneven flow effects and a receiver operating characteristic (ROC) analysis to predict fertility in comparison with the Neubauer method. This work demonstrates that SCA CASA technology is not a standalone 'black box', but rather a tool for well-trained staff that allows rapid, high-number sperm counting providing errors are identified and corrected. The system will produce accurate, linear, precise results, with less analytical variance than manual methods that correlate well against the Improved Neubauer chamber. The system provides superior predictive potential for diagnosing fertility problems.

  17. Minha casa, minha vida: extensão do direito à moradia e proteção constitucional

    Directory of Open Access Journals (Sweden)

    Guilherme Domingos de Luca

    2016-04-01

    Full Text Available O trabalho em questão busca analisar o Direito à moradia sob a ótica do Programa “Minha Casa, Minha Vida”. Demonstrará as ações do Estado visando a Regularização Fundiária, em face do interesse social no combate ao déficit imobiliário, além de analisar as hipóteses de perda do imóvel. O objetivo geral do estudo é compreender se há efetividade no direito à moradia a partir da vinculação ao Programa “Minha Casa, Minha Vida”, instituído pelo advento da Lei n° 11.977/09. De forma específica, o objetivo será entender o direito do indivíduo em adquirir novo imóvel, mesmo que em determinado momento teve de dispor de outro imóvel adquirido pelo Programa em questão. Trata-se de uma pesquisa pautada no método de investigação dedutivo, cujos procedimentos técnicos adotados foram livros, doutrinas, leis e jurisprudência. Com efeito, parte-se de um estudo bibliográfico e jurídico, para a posterior abordagem do atual contexto legislativo brasileiro mediante a adoção de um ponto de partida constitucional.

  18. The Casa Pizano and the Construction of Light Vaults in Colombia. The Origin of a Modern Tradition

    Directory of Open Access Journals (Sweden)

    Julián García

    2018-05-01

    Full Text Available At the beginning of the 20th Century several buildings were covered with tile vaults all through Latin America. However, two houses designed and built by Le Corbusier (the Maisons Sarabhai (Ahmadabad 1955 and Jaoul (Paris 1955 have traditionally been considered the main influence for later vaulted buildings covered with this technique in the area in the 60s and 70s. Since there were built examples contemporary or previous to the buildings by the Swiss architect, it seems logical to think that the influence of the Jaoul or Sarabhai houses in Latin American vault construction might have been somehow less relevant. There are several examples that support that idea: the most relevant is the Casa Pizano, a missing Bogota building designed by the local architect Francisco Pizano de Brigard, which was Le Corbusier's main inspiration for the aforementioned houses. The hypothesis of this paper is that local networks were also essential in the task of connecting similar technical initiatives regarding vault construction. To verify this hypothesis, several examples of buildings from different Latin American countries, starting from the Casa Pizano, will be studied, and some possible contacts between architects will be proposed.

  19. Evaluación del comportamiento sísmico de casas consistoriales de tapia pisada reforzadas con maderas de confinamiento

    OpenAIRE

    Ruiz, D; Silva, M; Cerón, L; López, C

    2017-01-01

    Existen pocos estudios del comportamiento de estructuras históricas en adobe y tapia pisada en Latinoamerica, lo que ha contribuido al deterioro de estas construcciones, que son patrimonio arquitectónico y cultural. Colombia tiene el 90% de sus edificios patrimoniales en tierra y la mayoría de ellos están ubicadas en zonas riesgo sísmico alto e intermedio. Las casas consistoriales de la época colonial (casas de ayuntamiento hechas en adobe o tapia pisada) son parte de este patrimonio arquitec...

  20. La “casa de la amistad”: Modos de construir y significar el hogar propio en jóvenes de la Ciudad de Buenos Aires

    OpenAIRE

    Felice, Magdalena

    2017-01-01

    Resumen: Este artículo analiza, desde una estrategia cualitativa-interpretativa, las experiencias de construcción de un hogar propio en jóvenes de sectores medios de la Ciudad de Buenos Aires que se fueron a vivir con amigos. Entre los resultados, se destaca que los amigos constituyen un soporte afectivo fundamental, en tanto la asociación con los pares permite afrontar el desafío de irse de la casa familiar de origen y construir un hogar propio. A su vez, la “casa de la amistad” se presenta ...

  1. PROGRAMA “CASA DAS GESTANTES”: UMA NOVA LÓGICA DE ATENÇÃO À SAÚDE MATERNA E PERINATAL

    OpenAIRE

    Adriano Maçal Pimenta; Juliana Vieira Nazareth; Kleyde Ventura de Souza

    2010-01-01

    El programa “Casa de las Embarazadas” es una estrategia del Ministerio de Salud Pública BR, teniendo en vista la equidad y humanización de la asistencia a las embarazadas de alto riesgo. Se trata de un estudio epidemiológico, transversal, descriptivo y exploratorio que se realizó en la “Casa de las Embarazadas” de una maternidad filantrópica en Belo Horizonte con el objetivo de evaluar el impacto de este programa en la salud materna de 292 embarazadas que usaron el servicio y de sus recién na...

  2. Internacionalização em Parceria: Construção de Casas Pré-Fabricadas em Moçambique

    OpenAIRE

    Vaz Figueiredo , César Augusto

    2017-01-01

    Neste mercado competitivo e dinâmico, as casas pré-fabricadas surgem como uma alternativa, tanto no mercado português, como nos mercados internacionais, às casas de fabrico convencional. A capacidade de serem mais acessíveis, resistentes, flexíveis de acordo com as necessidades dos clientes, com uma elevada eficiência energética e rápidas a nível da sua construção/montagem, têm sido os fatores de sucesso ao longo dos tempos. O projeto em questão tem como finalidade principal...

  3. Desenvolvimento de uma rede de sensores sem fio aplicada no monitoramento da variabilidade térmica em casas de vegetação

    OpenAIRE

    Barbosa, Rogério Zanarde [UNESP

    2015-01-01

    Este é um trabalho de tecnologia computacional aplicada na área agrícola, cujo objetivo principal do trabalho é desenvolver uma rede de sensores sem fio, que envolve aspectos de software e hardware, para o monitoramento térmico no interior de uma casa de vegetação. Além da rede propriamente dita, o trabalho também inclui a sua aplicação no levantamento quantitativo da variabilidade térmica na casa de vegetação o que pode ser aplicado em diversas atividades agrícolas a serem desenvolvidas no i...

  4. Ansiedad, depresión y síntomas psicosomáticos en una muestra de amas de casa

    OpenAIRE

    Ma. Pilar Matud; Juan Manuel Bethencourt

    2000-01-01

    En este estudio se analizan las variables más relevantes relacionadas con ansiedad, depresión y síntomas somáticos en una muestra de 180 amas de casa residentes en las Islas Canarias (España). En la predicción de la puntuación en depresión surgieron cinco predictores que explican el 44% de la variabilidad en síntomas depresivos. Las amas de casa que están más deprimidas son las de menor autoestima y apoyo social, las que se caracterizan por menor competitividad y hostilidad y las menos sat...

  5. Cuerpo y casa : hacia el espacio doméstico contemporáneo desde las transformaciones de la cocina y el cuarto de baño

    OpenAIRE

    Pardo Díaz, Gonzalo

    2016-01-01

    Los ámbitos vinculados tanto a la preparación de los alimentos como al cuidado del cuerpo revelan las transformaciones de la domesticidad a lo largo de la historia y permiten analizar los cambios más radicales de la casa y sus habitantes. Desde las primeras hogueras, el cocinar ha implicado un lugar, que una vez vinculado al habitar construido ha ido desplazándose por el espacio doméstico, ampliándose y reduciéndose, alejándose o acercándose al resto de los espacios de la casa en función de ...

  6. Education and Outreach through Ludo-Pedagogy and Experiential Learning. Bridging Feminist and Diversity Movements in Today's Nicaragua: An Interview with Helen Alfaro, Yova Briones, and Tannia Rizo Lazo of La Casa de los Colores

    Science.gov (United States)

    DeGrave, Analisa

    2016-01-01

    La Casa de los Colores (the House of Colors) is a feminist organization dedicated to defending human rights, particularly those of the LGBTQ+ community in León, Nicaragua. In 2016 Helen Alfaro, Yova Briones, Ani Guerrero, and Tannia Rizo Lazo, four members of La Casa's leadership team, "Las Coloras," were invited to speak about…

  7. Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland

    DEFF Research Database (Denmark)

    Schæbel, Louise Holm; Vestergaard, H; Laurberg, Peter Marvin

    2013-01-01

    Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids.......Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids....

  8. DANIEL MERRO JOHNSTON: EL AUTOR Y EL INTÉRPRETE. LE CORBUSIER Y AMANCIO WILLIAMS EN LA CASA CURUTCHET

    Directory of Open Access Journals (Sweden)

    Jorge Torres Cueco

    2011-11-01

    Full Text Available No hace mucho tiempo pudimos ver en la pantalla la película El hombre de al lado (Argentina, 2009 filmada en la Casa del Doctor Pedro Curutchet en Buenos Aires. También era su principal protagonista, pues el argumento gira alrededor de su inmarcesible presencia. La cámara de Mariano Cohn y Gastón Duprat nos muestran una sugestiva narración de la promenade architectural, sus atractivos espacios interiores, los juegos de luces y sombras otorgados por su brise-soleil y, también, su fragilidad ante las actuaciones poco respetuosas. Algunas imágenes nos recuerdan las tomas que Pierre Chenal hizo en Architecture d’Aujourd’hui (1930 con la colaboración del propio Le Corbusier, en esa escenificación de la promenade, entonces, por la villa Savoye. A este respecto Tim Benton insistía en la importancia del significado asociado a este deambular. La villa Stein mostraba diversas clases de naturaleza, en la villa Savoye el dominio de la arquitectura contra un medio antagonista, la naturaleza, que se hace presente desde el hueco con que finaliza el recorrido por la rampa. En la casa Curutchet nos encontramos un árbol ante el que se producen todos los desplazamientos: es una porción de naturaleza encerrada en un patio. Es casi una homotecia en relación con el parque ante el que se sitúa la casa y la metrópolis de Buenos Aires. Quizás haya también una reflexión entre el habitar y el trabajar en la gran ciudad, tan presente en el pensamiento de Le Corbusier. Estos son interpretaciones que no constituyen verdad alguna, sino asociaciones de ideas que no tienen más validez que retazos de memoria y que, en modo alguno, tratan de suplantar la realidad que se encuentra en la misma obra de arquitectura. Muy distinto es el objetivo de Daniel Merro. No nos ofrece una interpretación sobre esta obra, sino que nos relata cómo es interpretada una misma partitura cuyo pentagrama se tiende a lo largo de una rampa.

  9. Estimation of Net Rice Production through Improved CASA Model by Addition of Soil Suitability Constant (ħα

    Directory of Open Access Journals (Sweden)

    Syed Muhammad Hassan Raza

    2018-05-01

    Full Text Available Net primary production (NPP is an important indicator of the supply of food and wood. We used a hierarchy model and real time field observations to estimate NPP using satellite imagery. Net radiation received by rice crop canopies was estimated as 27,428 Wm−2 (215.4 Wm−2 as averaged throughout the rice cultivation period (RCP, including 23,168 Wm−2 (118.3 Wm−2 as averaged as shortwave and 4260 Wm−2 (34.63 Wm−2 as averaged as longwave radiation. Soil, sensible and latent heat fluxes were approximated as 3324 Wm−2, 16,549 Wm−2, and 7554 Wm−2, respectively. Water stress on rice crops varied between 0.5838 and 0.1218 from the start until the end of the RCP. Biomass generation declined from 6.09–1.03 g/m2 in the tillering and ripening stages, respectively. We added a soil suitability constant (ħα into the Carnegie-Ames-Stanford Approach (CASA model to achieve a more precise estimate of yield. Classification results suggest that the total area under rice cultivation was 8861 km2. The spatial distribution of rice cultivation as per suitability zone was: 1674 km2 was not suitable (NS, 592 km2 was less suitable (LS, 2210 km2 was moderately suitable (MS and 4385 km2 was highly suitable (HS soil type with ħα ranges of 0.05–0.25, 0.4–0.6, 0.7–0.75 and 0.85–0.95 of the CASA based yield, respectively. We estimated net production as 1.63 million tons, as per 0.46 ton/ha, 1.2 ton/ha 1.9 ton/ha and 2.4 ton/ha from NS, LS, MS and HS soil types, respectively. The results obtained through this improved CASA model, by addition of the constant ħα, are likely to be useful for agronomists by providing more accurate estimates of NPP.

  10. A experiência de famílias rurais que permanecem em casas de apoio durante tratamento oncológico

    Directory of Open Access Journals (Sweden)

    Nara Marilene Oliveira Girardon-Perlini

    2017-04-01

    Full Text Available RESUMO Objetivo Compreender a experiência de famílias rurais que permanecem em casas de apoio durante o tratamento oncológico de um familiar adulto. Métodos Pesquisa qualitativa fundamentada no Interacionismo Simbólico e na pesquisa narrativa. Participaram sete famílias rurais, 14 pessoas hospedadas em casas de apoio em Santa Maria, Rio Grande do Sul, Brasil. Os dados obtidos por meio de entrevista, no período de novembro de 2010 a maio de 2011, foram analisados com ênfase no conteúdo. Resultados Os três temas abordados foram: casa de apoio como um local de referência para ficar, o cotidiano e a convivência na casa de apoio. Conclusões A experiência foi marcada pela necessidade da família adaptar-se a um contexto diferente do rural, com regras e rotinas específicas, com desconfortos e confrontos com características da cultura urbana e com o vivido por outras famílias também em situação de adoecimento, o que contribuiu para ressignificar a própria experiência.

  11. Aprendiendo en Casa: Media as a Resource for Learning among Hispanic-Latino Families. A Report of the Families and Media Project

    Science.gov (United States)

    Lee, June; Barron, Brigid

    2015-01-01

    The Hispanic-Latino population is one of the largest--and most diverse--demographics in the U.S. Aprendiendo en casa reveals findings from a national survey of Hispanic parents about their home media environments and practices, and their perceptions of their children's use of educational media across a range of different platforms. The report…

  12. "Do You Hear with Your Ears or with Your Eyes?": The Education of the Deaf Pupils at Casa Pia De Lisboa (c.1820-1950)

    Science.gov (United States)

    Martins, Catarina S.

    2009-01-01

    This paper focuses on the education of the deaf pupils at Casa Pia de Lisboa, a Portuguese boarding-school, covering the period from 1820 to 1950. The intention is to show that a historical sedimentation of a scientific discourse about deafness is an effect of a new rationality of government begun by modernity and perfectly fitting a bio-political…

  13. Computer-Assisted Sperm Analysis (CASA) parameters and their evolution during preparation as predictors of pregnancy in intrauterine insemination with frozen-thawed donor semen cycles.

    Science.gov (United States)

    Fréour, Thomas; Jean, Miguel; Mirallié, Sophie; Dubourdieu, Sophie; Barrière, Paul

    2010-04-01

    To study the potential of CASA parameters in frozen-thawed donor semen before and after preparation on silica gradient as predictors of pregnancy in IUI with donor semen cycles. CASA parameters were measured in thawed donor semen before and after preparation on a silica gradient in 132 couples undergoing 168 IUI cycles with donor semen. The evolution of these parameters throughout this process was calculated. The relationship with cycle outcome was then studied. Clinical pregnancy rate was 18.4% per cycle. CASA parameters on donor semen before or after preparation were not significantly different between pregnancy and failure groups. However, amplitude of lateral head displacement (ALH) of spermatozoa improved in all cycles where pregnancy occurred, thus predicting pregnancy with a sensitivity of 100% and a specificity of 20%. Even if CASA parameters do not seem to predict pregnancy in IUI with donor semen cycles, their evolution during the preparation process should be evaluated, especially for ALH. However, the link between ALH improvement during preparation process and pregnancy remains to be explored. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

  14. La gubernamentalidad en lugares turísticos. Los casos de Christiania, Dinamarca, y San Cristóbal de las Casas, México

    DEFF Research Database (Denmark)

    Velázquez, Mario; Clausen, Helene Balslev

    2016-01-01

    The article analyzes conflicts over the use of place between a community and the State. We address two specific cases: Christiania in Copenhagen (Denmark) and San Cristobal de las Casas in Chiapas (Mexico) where significant social protests or cultural revolutions have taken place. In Christiania we...

  15. Viviendo Con Incendios: Una guia para los duenos de casas en Nuevo Mexico [Living with Fire: A Guide for the Homeowner-New Mexico

    Science.gov (United States)

    U.S. Department of the Interior Bureau of Land Management

    2008-01-01

    La posibilidad de perdidas humanas y de propiedad en Nuevo Mexico debido a un incendio forestal ha ido incrementando. Para responder a este peligro, entidades locales, estatales, federales, particulares y sin fines de lucro se han unido para crear Como Reducir la Amenaza de Incendios Forestales, un programa dirigido a los propietarios de casas. Este no es un programa...

  16. Parir en casa, parir en el hospital. Algunas dimensiones para el análisis de los lugares del parto

    Directory of Open Access Journals (Sweden)

    María Belén Castrillo

    2015-12-01

    Full Text Available En una investigación doctoral sobre la intervención médica en el proceso de embarazo, parto y puerperio, resulta relevante preguntarnos por la espacialidad del parto, de su atención/asistencia, por los actores involucrados y por las dinámicas diversas que generan y son generadas por los distintos lugares en los que sucede. En estas líneas reflexionaremos sobre los lugares del parto, poniendo el énfasis en el que propone e impone el modelo médico hegemónico en salud, el hospital, y la “alternativa” que supone el parto en casa, retomando los aportes de la perspectiva geográfica.

  17. Casa-estudio núm. 25, de Arts & Architecture, en Los Ángeles, (U. S. A.

    Directory of Open Access Journals (Sweden)

    Killingsworth – Brady - Smith, Arquitectos and Associate

    1966-10-01

    Full Text Available This house has two storeys, the lower one containing a large open vestibule and the living zone: dining room, kitchen, services and garage. The top floor has a study (which can be converted into a bedroom, if need be, a main and a secondary bedroom and two bathrooms. This house is notable in many senses, and defines a new and highly interesting design criterion.Desarrollada en dos plantas aloja, en la baja, un amplio vestíbulo abierto, la zona de vivir diurna, comedor, cocina, servicios y garaje. Y en la planta superior, un. Estudio— convertible en caso de necesidad en dormitorio—, dormitorio principal, un segundo dormitorio y dos baños. La casa es notable en muchos aspectos y marca una pauta interesante a seguir.

  18. Economías literarias en algunas ficciones argentinas del 2000 [Casas, Incardona, Cucurto y Mariano Llinás

    Directory of Open Access Journals (Sweden)

    Sandra Contreras

    2010-11-01

    Full Text Available In the context of discussions around "value" in times of post-autonomy, there appears a map articulating the diverse ways in which the narrative texts of poets Fabián Casas, Washington Cucurto and Juan Diego Incardona re-invent the populist imaginary [neighbourhood nostalgia displaced to the representational void of Zen experience; ideological and political reintegration of the collective subject; revolutionary discourse in the guise of farce and banality] while at the same time defining from such inflections three fictional economies corresponding to three positions with respect to work as one of the cores of new capitalism culture: leisure, craftsmanship and overproduction. The film Historias Extraordinarias by Mariano Llinás constitutes another version of the craftwork model and, with its particular economy, a narrative event in present Argentine fiction

  19. Gilberto Freyre: Indiciarismo, Emoção e Política na Casa-grande e na Senzala

    OpenAIRE

    COELHO, C. M.

    2007-01-01

    Este ensaio propõe a investigação da relação interdependente entre indiciarismo, emoção e política no pensamento de Gilberto Freyre, no período que vai de sua infância (1906) até o lançamento de sua obra germinal Casa-Grande & Senzala (1933). O autor lançou mão de parâmetros científicos da análise compreensiva valorizando o caráter subjetivo do conhecimento , da micro-análise social analisando as particularidades dos fenômenos estudados , e da análise detetivesca investigando os pormeno...

  20. Autoficción y trabajo de memoria en La casa de los conejos de Laura Alcoba

    Directory of Open Access Journals (Sweden)

    Bruno Ragazzi

    2013-11-01

    Full Text Available Este artículo se propone indagar acerca de las representaciones discursivas en el campo de memoria que se presentan en La casa de los conejos de Laura Alcoba. Se cree que la elección del género de la autoficción es una herramienta genérica que permite descubrir nuevas narrativas mnémicas en torno al enfrentamiento desigual entre Montoneros y las fuerzas represivas de la derecha. Estas novedosas maneras de ver el pasado se vinculan con lo que Ricoeur ha denominado “trabajo de memoria”, una elaboración terapéutica sobre el recuerdo que permite a un pueblo abrirse hacia la esperanza y el perdón.

  1. Estágio em uma casa de parto do Japão: relato de experiência

    OpenAIRE

    Hoga, Luiza Akiko Komura

    2005-01-01

    O conhecimento da assistência ao parto desenvolvida em outras sociedades pode promover a autocrítica a respeito de nossas próprias práticas. Este artigo relata a experiência de um estágio desenvolvido em uma Casa de Parto do Japão. A Instituição oferece assistência pré-natal, grupo de educação em saúde, ioga, hidroginástica, assistência ao parto e puerpério, cuidado com o recém-nascido, visita domiciliar e consulta de enfermagem da puérpera e recém-nascido. Os princípios que norteiam a assist...

  2. La denuncia a través de la mujer: La casa de la laguna, de Rosario Ferré

    Directory of Open Access Journals (Sweden)

    Ana Molestina

    2015-08-01

    Full Text Available La historia puertorriqueña es una historia de imposiciones identitarias, choques culturales y ambivalencia desde la llegada de los españoles a la isla. En La casa de la laguna, Ferré analiza el pasado  y el presente de Puerto Rico. Crea una reconstrucción simbolizada en la historia de las familias Mendizábal-Monfort, en la cual Isabel Monfort, trata de descubrir las causas del fracaso de su matrimonio. En esta búsqueda y reflexión personal, se representan las versiones olvidadas o silenciadas de la historia puertorriqueña y de igual manera, da voz y vida a las mujeres marginadas o silenciadas.

  3. Economías literarias en algunas ficciones argentinas del 2000 [Casas, Incardona, Cucurto y Mariano Llinás

    Directory of Open Access Journals (Sweden)

    Sandra Contreras

    2011-11-01

    Full Text Available In the context of discussions around "value" in times of post-autonomy, there appears a map articulating the diverse ways in which the narrative texts of poets Fabián Casas, Washington Cucurto and Juan Diego Incardona re-invent the populist imaginary [neighbourhood nostalgia displaced to the representational void of Zen experience; ideological and political reintegration of the collective subject; revolutionary discourse in the guise of farce and banality] while at the same time defining from such inflections three fictional economies corresponding to three positions with respect to work as one of the cores of new capitalism culture: leisure, craftsmanship and overproduction. The film Historias Extraordinarias by Mariano Llinás constitutes another version of the craftwork model and, with its particular economy, a narrative event in present Argentine fiction

  4. Selective enrichment of Eicosapentaenoic acid (20:5n-3) in N. oceanica CASA CC201 by natural auxin supplementation.

    Science.gov (United States)

    Udayan, Aswathy; Arumugam, Muthu

    2017-10-01

    The present study aims to evaluate the effect of different concentration of natural auxin, Indole-3 acetic acid (IAA) on growth, lipid yield, PUFA and EPA accumulation in Nannochloropsis oceanica CASA CC201. It was observed that the, treatment with 10ppm concentration of IAA resulted in high cell number 579.5×10 6 cells/ml than the control (215.5×10 6 cells/ml). Treatment with IAA at a concentration of 40ppm gives the highest cellular lipid accumulation of 60.9% DCW than the control 31.05% DCW). Lipid yield is also found to be increased by the addition of 40ppm IAA (319.5mg/L) compared with the control (121.5mg/L). EPA percentage is increased to 10.76% by the addition of 40ppm IAA compared to the control (1.87%). Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Liderazgos juveniles en construcción: el proceso de asambleas en la Casa de la Juventud (Canoas, Brasil

    Directory of Open Access Journals (Sweden)

    Bruna Rossi Koerich

    2016-12-01

    Full Text Available Este artículo tiene como objetivo analizar cómo la construcción de espacios de liderazgo juvenil contribuyó a una política de prevención de la violencia en la municipalidad de Canoas, Brasil, así como proporcionar una discusión sobre el proceso que llevó a la construcción de espacios concretos de liderazgo de los jóvenes en el proyecto social de la seguridad pública Casa de la Juventud orientado a jóvenes y adolescentes expuestos a factores de riesgo de la delincuencia. Se busca demostrar cómo la construcción de la cultura de paz por medio de la participación de los jóvenes en dicho proyecto se presenta como un aspecto positivo de prevención de la violencia.

  6. O Programa Minha Casa, Minha Vida na política habitacional brasileira : continuidades, inovações e retrocessos

    OpenAIRE

    Alexandre José Romagnoli

    2012-01-01

    Este trabalho tem por objetivo analisar a Política Nacional de Habitação do governo Lula através do Programa Minha Casa, Minha Vida (PMCMV). A análise se concentra nas continuidades, inovações ou eventuais retrocessos presentes no PMCMV comparativamente à Política de Habitação historicamente construída no Brasil. Partimos do pressuposto de que a questão habitacional é retomada no país com o início do governo Lula, que passa a viabilizar um processo de mudança na área, como, por exemplo, a cri...

  7. Alimentação fora de casa e excesso de peso: uma análise dos mecanismos explicativos

    Directory of Open Access Journals (Sweden)

    Ilana Nogueira Bezerra

    2016-09-01

    Full Text Available Objetivo: Discutir os possíveis mecanismos da relação entre consumo de alimentos fora do domicílio e ganho excessivo de peso. Métodos: Realizou-se um levantamento bibliográfico de artigos científicos que descrevessem as características dos alimentos consumidos fora do domicílio e de artigos que investigassem a relação entre essas características e o ganho excessivo de peso, publicados nas bases de dados: MEDLINE, Biblioteca Latino-Americana e do Caribe (LILACS e Scientific Eletronic Library Online (SciELO. Resultados: Constatouse que diversas características da alimentação fora do domicílio como a elevada densidade energética, o elevado teor de gorduras e açúcares, baixo conteúdo de fibras e cálcio, grandes porções de alimentos altamente palatáveis e ofertados em grande variedade e o consumo elevado de refrigerantes e doces contribuem para o ganho excessivo de peso. Conclusão: Constatada a importância da influência da alimentação fora do domicílio no ganho de peso, várias propostas são sugeridas para melhorar a oferta de alimentos saudáveis nas refeições realizadas fora de casa, no entanto, mais estudos são necessários para compreender quais mudanças no setor de alimentação fora de casa são efetivas para reduzir os impactos negativos na saúde da população.

  8. O IMAGINÁRIO RURAL DO LEITOR URBANO: o sonho mítico da casa no campo

    Directory of Open Access Journals (Sweden)

    Gislene Silva

    2009-06-01

    Full Text Available Esta pesquisa procura compreender um fenômeno aparentemente comum: o sonho de muitos moradores urbanos em ter uma casa no campo. A investigação é feita junto aos leitores da revista Globo Rural, uma publicação especializada em atividades agrícolas. São assinantes que residem na cidade de São Paulo e não possuem nenhum tipo de propriedade no meio rural. O propósito deste estudo é tentar apreender os movimentos desse imaginário, contribuindo para o debate das conexões entre campo e cidade e para o entendimento da interação entre sujeitos e produtos culturais simbólicos, no cotidiano urbano contemporâneo. Diante da complexa relação do homem com a natureza e da condição histórica vivida numa metrópole nesta virada de século, percebe-se que, ao sonhar com a casa no campo, os leitores urbanos da revista não apenas se voltam de maneira saudosa para o passado rural. No tempo presente, eles tecem uma crítica profunda ao modelo civilizatório da urbanidade da metrópole e, olhando para frente, imaginam um futuro melhor fora da cidade, no meio rural, mais perto das coisas da natureza, num lugar mais solidário, longe da violência, do trânsito pesado, da poluição e com mais qualidade de vida.

  9. O imaginário rural do leitor urbano: o sonho mítico da casa no campo

    Directory of Open Access Journals (Sweden)

    Gislene Silva

    2009-06-01

    Full Text Available Esta pesquisa procura compreender um fenômeno aparentemente comum: o sonho de muitos moradores urbanos em ter uma casa no campo. A investigação é feita junto aos leitores da revista Globo Rural, uma publicação especializada em atividades agrícolas. São assinantes que residem na cidade de São Paulo e não possuem nenhum tipo de propriedade no meio rural. O propósito deste estudo é tentar apreender os movimentos desse imaginário, contribuindo para o debate das conexões entre campo e cidade e para o entendimento da interação entre sujeitos e produtos culturais simbólicos, no cotidiano urbano contemporâneo. Diante da complexa relação do homem com a natureza e da condição histórica vivida numa metrópole nesta virada de século, percebe-se que, ao sonhar com a casa no campo, os leitores urbanos da revista não apenas se voltam de maneira saudosa para o passado rural. No tempo presente, eles tecem uma crítica profunda ao modelo civilizatório da urbanidade da metrópole e, olhando para frente, imaginam um futuro melhor fora da cidade, no meio rural, mais perto das coisas da natureza, num lugar mais solidário, longe da violência, do trânsito pesado, da poluição e com mais qualidade de vida.

  10. Comunicação no engajamento voluntário: case Casa de Apoio Santa Bernadete

    Directory of Open Access Journals (Sweden)

    Ana Paula Oliveira Rocha

    2013-02-01

    Full Text Available Introdução: A comunicação na contemporaneidade é palco de expressivas transformações mediando relações em todo o corpo social. Campanhas publicitárias se tornam produtos indispensáveis a todos os setores e instâncias sociais em vias de fruição de resultados e otimização de projetos. Também o Terceiro Setor, ao largo de sua fenomenologia, alia-se ao fazer publicitário na condução de suas atividades. Objetivo: Neste prospecto, o presente trabalho propõe-se a desenvolver uma campanha publicitária para a Casa de Apoio Santa Bernadete, entidade filantrópica voltada ao acolhimento do público com diagnóstico de câncer e vulnerabilidade social. Metodologia: Através de um estudo de caso, procedeu-se à entrevista, dirigida ao núcleo diretor da instituição, marcando-se o viço publicitário da campanha. Resultados: O engajamento voluntário foi o intento escolhido pela entidade no desenvolvimento do trabalho. Os dados coletados foram combinados em briefing na orientação das decisões criativas, resultando no produto de uma campanha publicitária pertinente à necessidade comunicacional da casa. Considerações finais: A publicidade emerge como uma ferramenta de grande valia no trato organizacional, aqui se denota o usufruto dos produtos de comunicação na efetivação de resultados de escopo assistencial.

  11. Performance of InsCor and three international scores in cardiac surgery at Santa Casa de Marília.

    Science.gov (United States)

    Tiveron, Marcos Gradim; Bomfim, Helton Augusto; Simplício, Maycon Soto; Bergonso, Marcos Henriques; Matos, Milena Paiva Brasil de; Ferreira, Sergio Marques; Pelloso, Eraldo Antônio; Barros, Rubens Tofano de

    2015-01-01

    To apply and to compare the Society of Thoracic Surgery score (STS), EuroSCORE (Eurosc1), EuroSCORE II (Eurosc2) and InsCor (IS) for predicting mortality in patients undergoing to coronary artery bypass graft and/or valve surgery at the Santa Casa Marilia. The present study is a cohort. It is a prospective, observational, analytical and unicentric. We analyzed 562 consecutive patients coronary artery bypass graft and/or valve surgery, between April 2011 and June 2013 at the Santa Casa Marilia. Mortality was calculated for each patient through the scores STS, Eurosc1, Eurosc2 and IS. The calibration was calculated using the Hosmer Lemeshow test and discrimination by ROC curve. The hospital mortality was 4,6%. The calibration is generally adequate group P=0.345, P=0.765, P=0.272 and P=0.062 for STS, Eurosc1, Eurosc2, and IS respectively. The discriminatory power of STS score 0.649 (95% CI 0.529 to 0.770, P=0.012), Eurosc1 0.706 (95% CI 0.589 to 0.823, P ≤0.001), Eurosc2 was 0.704 (95% CI 0.590-0.818 P=0.001) and InsCor 0.739 (95% CI 0.638 to 0.839, P ≤0.001). We can say that overall, the InsCor was the best model, mainly in the discrimination of the sample. The InsCor showed good accuracy, in addition to being effective and easy to apply, especially by using a smaller number of variables compared to the other models.

  12. Solubility of calcium in CaO-CaCl2

    International Nuclear Information System (INIS)

    Perry, G.S.; Shaw, S.J.

    1991-06-01

    The Direct Oxide Reduction (DOR) process is well established as a process to produce plutonium metal from plutonium dioxide by reaction with calcium. Calcium chloride is added to dissolve the calcium oxide produced, allowing the metal to coalesce into a button. Since calcium metal melts at 840 0 C and DOR can take place successfully below this temperature, it is likely calcium dissolved in calcium chloride reacts with the plutonium dioxide. The solubility of calcium in calcium chloride is reasonably well established but the effect of the CaO formed during the DOR process on the solubility of calcium has not been previously determined. For this reason the solubility of calcium in CaCl 2 -CaO melts at 800 o C has been studied. The solubility decreases from 2.7 mol % in CaCl 2 to 0.4 mol % in 9 mol % CaO-CaCl 2 . (author)

  13. Hegemonia e contra-hegemonia no processo de implantação da Casa de Parto no Rio de Janeiro Hegemonía y contra hegemonía en el proceso de implantación de la Casa de Parto en Rio de Janeiro Hegemony and counter-hegemony in the process of implementing the Casa de Parto Birth Center in Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Adriana Lenho de Figueiredo Pereira

    2009-12-01

    Full Text Available Estudou-se o processo de implantação da primeira Casa de Parto no Sistema Único de Saúde (SUS da cidade do Rio de Janeiro. Por meio de pesquisa qualitativa objetivou-se identificar os determinantes do processo de implantação da Casa de Parto e analisar a influência dos grupos hegemônicos e contra-hegemônicos neste processo de implantação. O referencial teórico foi o conceito de hegemonia. O método dialético orientou a análise dos dados por meio das categorias metodológicas: contradição, totalidade e historicidade. Foram realizadas entrevistas semiestruturadas no período de janeiro a julho de 2007. Os entrevistados foram quatro gestores da saúde municipal e onze profissionais técnico-administrativos designados para implantar a Casa de Parto. A síntese deste estudo revelou que a implantação da Casa de Parto foi determinada pela contra-hegemonia estabelecida na assistência à gestação e parto fisiológicos.Se estudió el proceso de implantación de la primera Casa de Parto en el Sistema Único de Salud (SUS en la ciudad del Rio de Janeiro. Por medio de una investigación cualitativa se objetivó identificar los determinantes del proceso de implantación de la Casa de Parto y analizar la influencia de los grupos hegemónicos y contra hegemónicos en ese proceso de implantación. El marco teórico fue el concepto de hegemonía. El método dialéctico orientó el análisis de los datos por medio de las categorías metodológicas: contradicción, totalidad e historicidad. Fueron realizadas entrevistas semiestructuradas en el período de enero a julio de 2007. Los entrevistados fueron cuatro gestores de la salud municipal y once profesionales técnicos y administrativos designados para implantar la Casa de Parto. La síntesis de este estudio reveló que la implantación de la Casa de Parto fue determinada por la contra hegemonía establecida en la asistencia a la gestación y parto fisiológicos.This study addressed the

  14. A Casa Portuguesa como representação de Portugal: subversões da escrita da casa em romances portugueses da segunda metade do século XX = The Portuguese House as the representation of Portugal: subversion of the house’s writing in portuguese novels published in the second half of twentieth century

    Directory of Open Access Journals (Sweden)

    Girola, Maristela Kirst de Lima

    2012-01-01

    Full Text Available O presente ensaio tem como objetivo tecer e discutir algumas reflexões sobre a construção ficcional do espaço da casa como representação de Portugal. Em romances publicados na segunda metade do século XX, por autores como Agustina Bessa-Luís, Maria Velho da Costa e António Lobo Antunes, podemos perceber subversões na forma de escrever a casa portuguesa. Procuraremos relacionar essas mudanças às transformações sociais e à construção do gênero romanesco

  15. Las nuevas casas de la Inquisición en Santiago de Compostela: del palacio de Monterrey a la sede de Porta da Mámoa

    Directory of Open Access Journals (Sweden)

    Pita Galán, Paula

    2012-12-01

    Full Text Available In 1726 the Inquisition decided to rebuild its building: the Palace of Monterrey, in Santiago de Compostela. This intervention should have been made according to a project of Fernando de Casas but caused the moving of the Santo Oficio to a new building known as Casa Grande del Horreo or de Calo, in front of Porta da Mámoa. Thanks to unknown documents and the collection of plates of the Inquisition conserved at Archivo Histórico Universitario de Santiago, we will analized the circumstances that caused the change of building as well as propose an hypothetical reconstruction of the Casa de Calo from the testimonies of those who knew it before of the deep removal, directed by the master mason of San Martín Pinario fray Francisco Velasco that transform it into a Palace of the Inquisition.

    En 1726 el Tribunal de la Inquisición se propuso remodelar sus instalaciones en el Palacio de Monterrey, en Santiago de Compostela. Dicha intervención, que debía realizarse según un proyecto de Fernando de Casas, determinó el traslado del Santo Oficio a un nuevo inmueble: la Casa Grande del Hórreo o de Calo, frente a la Porta da Mámoa. A partir de documentación inédita y del estudio de la colección de planos de la Inquisición que conserva el Archivo Histórico Universitario de Santiago, analizaremos las circunstancias que motivaron el cambio de sede, y reconstruiremos la Casa de Calo según los testimonios de quienes la conocieron antes de que una profunda remoción dirigida por fray Francisco Velasco, maestro de obras de San Martín Pinario, la transformase en un palacio de la Inquisición. [gl] En 1726 o Tribunal da Inquisición propúxose remodelar a súas instalacións no Pazo de Monterrey, en Santiago de Compostela. Dita intervención, que debíase realizar seguindo un proxecto de Fernando de Casas, determinou o traslado do Santo Ofi cio a un novo inmoble: a Casa Grande do Hórreo ou de Calo, frente a Porta da Mámoa. A partir de

  16. Italia: La chiusura della Casa dell’Emigrante come spunto riflessione sui rientri degli emigrati italiani

    Directory of Open Access Journals (Sweden)

    2009-01-01

    Full Text Available In the literature on migration, as well as in social policies regarding this phenomenon, the situation of returning emigrants receives scant attention. This essay establishes an intricate connection between attitudes and policies that prevail in a country regarding emigration and those concerning immigration. The case of Italy provides a prime example for this as it once was a classical country of emigration, only to turn, in recent decades, into a country that appears highly attractive (and relatively accessible to immigrants. The essay traces the pervasive ambiguity that characterizes this country’s attitudes towards emigration from the beginning of mass emigration shortly after the unification of Italy in 1868 to the emigration policies of the fascist regime of Mussolini and the post-World War II waves of emigration right through to the corresponding ambiguity concerning the status of immigrants in contemporary society, including the indifferent treatment of returning Italian emigrants who constitute a considerable numerical phenomenon. These reflections take their origin from the impending closure of a reception centre in Lazio, the Casa dell’Emigrante near Sant’Elia Fiumerapido, Province of Frosinone, ostensibly for financial reasons. This centre had been the only one of its kind in the whole of Italy dealing officially with the needs of repatriated Italians. It had assisted returning emigrants both with practical matters, such as negotiating the labyrinth of Italian bureaucracy , and with psychological implications of a return, which are often considerable given the time lag of experiences with current social realities and the frequently unrealistic expectations associated with the return. Questions of identity become highly acute in those circumstances. The threatened closure of the centre illustrates the unwillingness of the state to face up to the factual prevalence of migratory experiences in the country as a whole and as a core

  17. Accessing the nuclear symmetry energy in Ca+Ca collisions

    Directory of Open Access Journals (Sweden)

    Chbihi A.

    2012-07-01

    Full Text Available The status of the analysis of the INDRA-VAMOS experiement performed at GANIL, using the reactions 40,48Ca+40,48Ca reactions at 35AMeV, are presented. Isotopic distributions of fragments produced in multifragmentation events provide information on the importance of the surface term contribution in the symmetry energy by comparison to AMD predictions.

  18. Salud oral en población geriátrica: experiencia en una casa de abuelos

    Directory of Open Access Journals (Sweden)

    Eva Ordaz Hernández

    2015-06-01

    Full Text Available Introducción: el nuevo milenio convierte el envejecimiento poblacional en uno de los desafíos más importantes para las sociedades modernas. Objetivo: caracterizar el comportamiento de la salud bucal de los adultos mayores, residentes en la Casa del Abuelo del municipio Pinar del Río. Material y método: se realizó un estudio transversal y descriptivo con adultos mayores residentes en la casa del abuelo del municipio Pinar del Río, en el mes de octubre de 2013. Se determinaron las variables y aplicó una encuesta. De los 40 adultos mayores que residían en dicha institución, se analizaron los 36 que se encontraban presentes en el periodo de la investigación. Resultados: se determinó que el grupo de edad entre 80 y 89 años, 44.4%, fue el más representativo; el 91,6% no asistió a consulta de estomatología, 17 adultos mayores viven en situación de soledad, y de ellos, 11 no mostraron motivación por asistir a consulta estomatológica. El 63,8% eran desdentados totales, el resto parciales; el 66,6% estaban rehabilitados, en su mayoría, con prótesis desajustadas. Conclusiones: se identificó el predominio del sexo masculino y el grupo etáreo de 80-89 años. La generalidad hacía más de un año que no visitaban al estomatólogo. Los ancianos que conviven en compañía mostraron en su totalidad motivación por acudir a consulta estomatológica, el hecho de vivir en situación de soledad los inhibió para asistir a este servicio de salud. La mayoría necesitaba tratamiento protésico.

  19. El "peixet": La experiencia de parir en casa The "peixet": The experience of giving birth at home

    Directory of Open Access Journals (Sweden)

    Ana Belén Rodríguez Feijóo

    2009-03-01

    Full Text Available El relato biográfico que nos ocupa, se basa en la experiencia vivida por una pareja (Elia y Daniel que quería vivir el parto de su primera hija (Illary de la forma más natural posible, por eso decidieron que naciera en casa. Su acceso a instituciones o profesionales (matronas que los ayudaran a realizar su deseo, fue relativamente fácil, al vivir en una comunidad autónoma (Cataluña en la que la oferta con respecto al parto en casa es superior a otras comunidades, dentro de la escasez existente en tal ámbito. Tras informarse del proceso y de la oferta existente, se decidieron por una asociación especializada, de la que formaba parte la matrona que finalmente los atendió (se omiten nombres reales. El título dado a esta historia, el peixet (traducido al castellano significa el pececillo, se debe a ser este el apodo cariñoso dado por estos padres a su hija, al producirse el nacimiento en el agua. Su valoración final del parto es positiva, deseando repetirla, a pesar del coste económico y de la falta de apoyo y comprensión social.Interview that occupies to us, bases on experience lived by pair (Elia and Daniel who wanted to live the childbirth of their first daughter (Illary of the possible most natural form, for that reason decided that it was born at home. Their access to institutions or professionals (midwives who helped them to make their desire, it was relatively easy to live in an autonomous community (Cataluña in which the supply with respect to the childbirth at home is superior to other communities within the existing shortage in such scope. After inquiring into the process and the existing supply, they were decided by a specialized association, which was part or the midwife comprised that finally took care of them (real name are omitted. The title given to this history, peixet (translated the Castilian it means the small fish, is due to this being the affectionate nickname given by these parents to their daughter, when taking

  20. El gobierno de la casa en Atenas clásica: género y poder en el "oikos"

    Directory of Open Access Journals (Sweden)

    María Dolores MIRÓN PÉREZ

    2010-02-01

    Full Text Available RESUMEN: La sociedad ateniense de los siglos V y IV a.C. es una de las que con mayor nitidez presenta diferenciación de papeles y espacios según el género: exterior/£> o/¿s/varón e interior/oz&os/mujer. Frente al poder público de los varones, la dirección de los asuntos internos del hogar es entendida como esfera de autoridad naturalmente femenina. No obstante esta división de competencias, ellas también conocen los asuntos externos de la casa, ya que el gobierno de ésta en todos sus ámbitos tiende a ejercerse conjuntamente por el marido y la esposa, siendo las funciones de ambos interdependientes e igualmente importantes. Esta autoridad femenina estará limitada por la decisión última del cabeza de familia, un varón, punto de intersección entre lo público y lo privado, y con capacidad legal en ambos ámbitos. La autoridad suprema en la casa corresponde al esposo, quien delega en su esposa las competencias para las que, por su naturaleza, se considera más apta una mujer. Sin embargo, ante la ausencia del marido, la esposa puede temporalmente erigirse de facto —aunque nunca legalmente— en auténtica cabeza de familia y en garante de la supervivencia del oikos.ABSTRACT: Athenian society of 5th and 4th centuries B. C. especially displays a clear gender differentiation of roles and spaces: exterior/^o/zVmen and interior/oz'&os/women. If men control public power, women exercise authority over the inner spheres of the household. Despite their different domains, women also have knowledge about external spheres, as both husband and wife jointly rule the household. Both domains were interdependent and equally important, but woman's authority was limited by the ultimate decision of the male head of household. He was the intermediary between the public and private worlds and he had legal capacity in both spheres. He is the supreme authority in the household and delegates to her wife the fields «naturally» more appropriate to women

  1. LA CASA CON PATIO EN MIES VAN DER ROHE / House with patio from Mies van der Rohe

    Directory of Open Access Journals (Sweden)

    José Altés Bustelo

    2013-05-01

    Full Text Available RESUMEN Una revisión del tema Casa con Patio, con especial atención a los planteamientos desarrollados por Mies van der Rohe durante sus últimos años en Berlín, a propósito del conocido dibujo denominado “Casa con tres patios”. Se explora su pensamiento arquitectónico a partir de los datos historiográficos de su trayectoria, más los que se pueden deducir del análisis de los dibujos y croquis previos del arquitecto. El conjunto de proyectos en que aparece el tema es muy amplio durante ese tiempo y los dibujos conservados ofrecen múltiples reflexiones. Sobre ese soporte se examinan conceptos relativos a la definición espacial y formal, donde aparecen cuestiones que ligan esa definición con los sistemas y materiales constructivos. Malla estructural, muro, pared de vidrio y patio vividero, vinculados necesariamente a sus respectivas cualidades tectónicas, adquieren el sentido de materiales de proyecto utilizados para definir un particular modo de entender la arquitectura en el que el usuario está presente siempre como destinatario de la misma. Finalmente, se plantea la utilidad didáctica del análisis de esos dibujos para el progreso del conocimiento en el proyecto arquitectónico.SUMMARY A review of the theme, House with Patio, with special reference to the plans developed by Mies van der Rohe during his last years in Berlin, in relation to the well–known drawing called: “House with three patios”. His architectural thoughts are explored through the historiographic data of his career, plus those that can be deduced from the analysis of the architect’s previous drawings and sketches. The group of projects, in which the theme appears is prolific from that time, and the preserved drawings offer multiple opportunities for reflection. Concepts on that medium are examined, relative to spatial and formal definition, where questions appear that link that definition with the constructive systems and materials. Structural mesh

  2. The inverted Ion mirror: the path to truth-telling in the story of Padre Justino in Crônica da casa assassinada

    Directory of Open Access Journals (Sweden)

    Patrícia Chanely Silva Ricarte

    2015-03-01

    Full Text Available Based on the ideas of Michel Foucault in the course The Government of Self and Others, I examine in this article the route of parrhesia, or truth-telling, attributed to the narrator Padre Justino in the five chapters of the novel Crônica da casa assassi­nada, by Lúcio Cardoso. From this perspective, my analysis focuses on two types of parrhesia, very similar to those from the play Ion, by Euripides identified and classi­fied by Foucault as oracular and confessional. While such discourses in Ion have the function of creating a genealogy for the city of Athenas, in Crônica da casa assassi­nada the acts of parrhesia by Padre Justino and Ana Meneses have, as a whole, the opposite function, serving for the abolition of a family tradition.

  3. Programa Nacional de Habitação Rural e modo de morar no campo: reflexões a partir da casa rural na Zona da Mata mineira

    Directory of Open Access Journals (Sweden)

    Aline Werneck Barbosa de Carvalho

    2017-02-01

    Full Text Available Resumo O Programa Nacional de Habitação Rural (PNHR constitui a vertente rural do Programa Minha Casa, Minha Vida - MCMV e tem como objetivo reduzir o déficit habitacional rural por meio da reforma ou construção de novas moradias. Apesar da importância desse Programa para a fixação do homem ao campo, neste artigo procura-se chamar a atenção para a necessidade de adequação da tipologia de casa do PNHR ao modo de morar na área rural. A pesquisa fundamentou-se na análise da habitação rural em Minas Gerais, mais especificamente na região da Zona da Mata, bem como na análise da legislação que rege o PNHR, como leis, portarias e decretos. Os resultados apontaram que as especificações técnicas mínimas estabelecidas pelo Ministério das Cidades para o PNHR desconsideram o modo de vida rural e os hábitos dos moradores. Embora haja o cuidado de não estabelecer áreas mínimas para os compartimentos, a fixação da área útil total em 36m2 e o dimensionamento induzido a partir do tamanho e descrição do mobiliário mínimo conduzem à formatação de um programa de necessidades muito semelhante ao da tipologia de casa adotado pela versão urbana do Programa Minha Casa Minha Vida.  Palavras-Chave: política habitacional, habitação rural, Programa Minha Casa Minha Vida.   Abstract The National Rural Housing Program (PNHR is the rural part of the “Minha Casa, Minha Vida” Program and aims to reduce rural housing deficit through the renovation or construction of new housing. Despite the importance of this program for fixing the men to the field, this paper aims to draw attention to the need to adapt the typology of the house of PNHR to the way of living in rural areas. The research was based on rural housing analysis in Minas Gerais, more specifically in the Zona da Mata region, as well as in the analysis of the legislation governing the PNHR. The results showed that the minimum technical specifications established by the

  4. La contabilidad de la Casa Ducal de Osuna durante la intervención real de su patrimonio (1591-1633

    Directory of Open Access Journals (Sweden)

    Jesús Damián López Manjón

    2007-07-01

    la descripción de varias de las cuentas presentadas por los mayordomos de diversas localidades del estado andaluz de la Casa, así como de otra diversa documentación contable de la misma. Del análisis de dicha documentación, puede afirmarse que el papel primordial de la contabilidad en la Casa ducal de Osuna en el periodo estudiado fue la rendición de cuentas de sus agentes. Para tal fin, se usó el sistema de cargo y descargo, como era común en otras organizaciones de la época. Por otro lado, podemos concluir que la contabilidad no jugó un papel relevante en las decisiones tomadas sobre la forma de gestión del patrimonio intervenido ni se produjeron cambios importantes en los flujos de información contable durante los años del embargo patrimonial.

  5. Infecção Hospitalar na visão de enfermeiros da Santa Casa de Bagé - RS

    Directory of Open Access Journals (Sweden)

    Marcelo Carneiro

    2012-01-01

    Full Text Available Hospital Infection(HI is that acquired after patient admission and thatmanifests during hospitalization or after discharge, whenit can be related to the hospital admission or procedures.The objective was to verify the point of view of the nursesof Santa Casa de Caridade de Bagé regarding hospitalinfections. Methods: This was an exploratory studycarried out with 32 nurses from Santa Casa de Caridadede Bagé. Data were collected using the in-depth interviewtechnique from July to August 2010, where the subjectsanswered questions about the association betweeninfection control and nursing care, in which answerswere submitted to the theme content analysis technique.Results: They were divided into three symbolic categories:definition of HI, nurses’ actions regarding HI and thenurses’ perception on HI managers. Conclusion: Theevaluation showed that nurses have a good theoreticalbackground on the subject, as they answered thequestions clearly and appropriately.

  6. “A Casa da Xuventude de Ourense como experiencia histórica de Educación Social. 1978 – 1992.”

    Directory of Open Access Journals (Sweden)

    Millán Brea Castro

    2015-12-01

    Full Text Available A través pues de esta tesis, se tratará de mostrar y captar el significado de la vida de la Casa de la Juventud, como generadora de espacios culturales innovadores, de conciencias críticas y también, impulsora de una metodología activa y participativa en el contexto juvenil de la ciudad de Ourense.El objetivo principal fue mostrar la Casa de la Juventud de Ourense como ejemplo de intervención desde la Educación Social desde el año 1978 al año 1992, contando con las opiniones de participantes claves de este proceso, así como los registros escritos de las diferentes actividades y notas de prensa del que acontecía en el día a día.

  7. Towards a Casa Segura: A Consumer Product Study of the Effect of Insecticide-Treated Curtains on Aedes aegypti and Dengue Virus Infections in the Home

    Science.gov (United States)

    Loroño-Pino, María Alba; García-Rejón, Julián E.; Machain-Williams, Carlos; Gomez-Carro, Salvador; Nuñez-Ayala, Guadalupe; del Rosario Nájera-Vázquez, Maria; Losoya, Arturo; Aguilar, Lyla; Saavedra-Rodriguez, Karla; Lozano-Fuentes, Saul; Beaty, Meaghan K.; Black, William C.; Keefe, Thomas J.; Eisen, Lars; Beaty, Barry J.

    2013-01-01

    The home, or domicile, is the principal environment for transmission of dengue virus (DENV) between humans and mosquito vectors. Community-wide distribution of insecticide-treated curtains (ITCs), mimicking vector control program-driven interventions, has shown promise to reduce DENV infections. We conducted a Casa Segura consumer product intervention study in Mérida, Mexico to determine the potential to reduce intradomicillary DENV transmission through ITC use in individual homes. Dengue virus infections in mosquitoes and in humans were reduced in homes with ITCs in one of two study subareas. Overall, ITCs reduced intradomicillary DENV transmission; ITC homes were significantly less likely to experience multiple DENV infections in humans than NTC homes. Dengue virus–infected Aedes aegypti females were reduced within the ITC homes where curtain use was highest. Some homes yielded up to nine infected Ae. aegypti females. This study provides insights regarding best practices for Casa Segura interventions to protect homes from intradomicillary DENV transmission. PMID:23732254

  8. Una Nota sobre la Construcción de Series de Precios de Activos Reales: Tierra y Casas en Chile Una Nota sobre la Construcción de Series de Precios de Activos Reales: Tierra y Casas en Chile

    OpenAIRE

    Raimundo Soto; Felipe Morandé

    1992-01-01

    Una Nota sobre la Construcción de Series de Precios de Activos Reales: Tierra y Casas en Chile This note presents previously unpublished data on prices of agricultural land in Chile's central region and houses (both rental and purchasing prices) in Santiago, with the corresponding methodology. As such, it is a follow-up to an Appendix in Morande (1992).

  9. ‘Una ventanita’: Vida cotidiana de las dueñas de casa y agencia de las máquinas tragamonedas en Chile

    Directory of Open Access Journals (Sweden)

    Francisco Olivos Ravé

    2012-07-01

    Full Text Available Este artículo intenta dar respuesta de forma etnográfica a la pregunta de cuál es el sentido que ocupan las máquinas tragamonedas y la agencia que estas tienen sobre la vida cotidiana de las dueñas de casa de un barrio de clase media baja en la comuna de San Bernardo, Santiago. Se descubre que el juego en las máquinas tragamonedas no constituye un momento extraordinario, sino que es parte de la rutina, pero a la vez permite una ruptura de la simultaneidad del tiempo libre con el de las labores del hogar que caracteriza a otras actividades como ver televisión. Sin embargo, gracias al enfoque de la teoría del actor red es posible observar que la agencia de las máquinas tragamonedas canaliza el escape de lo que significa la casa, es decir, de las responsabilidades y de los problemas familiares. Se genera, por otra parte, un encuentro de las dueñas de casa con su self. Asimismo, la agencia de las máquinas tragamonedas desencadena controversias en la familia volviéndola parte de la red que se forma en torno el juego. Finalmente, se plantea que las decisiones que se tomen en torno a la legislación sobre el juego deben tener en cuenta una traducción que permita comprender la lógica del juego en la vida cotidiana de las dueñas de casa y de los jugadores en general.

  10. Historia oral de una maloca sitiada en el Amazonas: Aspectos de la rebelión de Yarocamena contra la Casa Arana, en 1917

    Directory of Open Access Journals (Sweden)

    Roberto Pineda Camacho

    1989-01-01

    Full Text Available Basándose en fuentes en su mayor parte orales, comparadas, el autor construye la narración histórica: La rebelión de muchos grupos indígenas del Putumayo, trabajadores esclavos en la explotación del caucho, contra su opresor La Casa Arana; cuyo resultado final es la matanza de los caucheros, orquestada por el Ejército peruano.

  11. Epidemiological study of facial fractures at the Oral and Maxillofacial Surgery Service, Santa Casa de Misericordia Hospital Complex, Porto Alegre - RS - Brazil

    OpenAIRE

    Zamboni, Rodrigo Andrighetti; Wagner, João Carlos Birnfeld; Volkweis, Maurício Roth; Gerhardt, Eduardo Luis; Buchmann, Elissa Muller; Bavaresco, Caren Serra

    2017-01-01

    ABSTRACT Objectives: to investigate the incidence and etiology of face trauma with diagnosis of facial fracture treated at the Buccomaxillofacial Surgery and Traumatology Service of the Santa Casa de Misericórdia Hospital Complex in Porto Alegre. Methods: we conducted a cross-sectional, retrospective epidemiological study of 134 trauma victims with 153 facial fractures. Results: the male gender was the most affected (86.6%) and the incidence was higher in the age group from 21 to 30 yea...

  12. Comerciantes y casas comerciales relacionados con las actividades financieras en una ciudad caribeña de Colombia durante la segunda mitad del siglo XIX

    Directory of Open Access Journals (Sweden)

    Tomás Caballero Truyol

    2015-01-01

    Full Text Available Este trabajo tiene como objetivo analizar, a través de los protocolos notariales, elprototipo de comerciantes prestamistas en la economía barranquillera, durante lasegunda mitad del siglo XIX, mediante el caso particular de Don Esteban Márquez.También, describir cómo las casas comerciales, que se abrieron alrededor de lasactividades mercantiles y portuarias, se involucraron en el mercado financiero.

  13. Fuentes de contaminación intradomiciliaria y enfermedad respiratoria en jardines infantiles y salas cunas de Temuco y Padre Las Casas, Chile

    OpenAIRE

    Rivas R,Edith; Barrios C,Sara; Dorner P,Anita; Osorio S,Ximena

    2008-01-01

    Background: Indoor air pollution, is the main cause of population exposure to polluting agents. Aim: To establish an environmental profile of indoor contamination emission sources in families of children under 5years that assist to kindergartens in Temuco and Padre Las Casas. To associate respiratory disease episodes in children with indoor contamination. Material and methods: Cross sectional analysis of 355 family groups subjected to questionnaires about indoor contamination and number of re...

  14. PATRIMONIOS CORPORALES ANCESTRALES DEL PUEBLO INDÍGENA ZENÚ. EL CARGAMENTO E’ CASA COMO ESCENARIO DEL MONTUCUY ENTRE BAILES, JUEGOS, PITO ATRAVESAO Y GAITAS

    Directory of Open Access Journals (Sweden)

    Jairzinho Francisco Panqueba Cifuentes

    2016-03-01

    solidaridades en torno al esfuerzo físico, animando las energías con alimentos, bebidas y distintas manifestaciones de jolgorio. El Cargamento e’ casa evoca y convoca la imaginería lúdica zenú como un tributo —legado— de sus movimientos desde el juego, sus fuerzas ancestrales, el vigor de sus gentes y el poder de la solidaridad.

  15. The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

    Science.gov (United States)

    González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

    2014-01-01

    An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p calcareum Ca diets, but that was not the case if calcium carbonate was the source of Ca (interaction, p calcareum Ca was greater (p calcareum Ca. In conclusion, under the conditions of this experiment, standardised digestibility of Ca is not affected by the level of phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

  16. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    Directory of Open Access Journals (Sweden)

    Lílian Moura de Lima

    2011-03-01

    Full Text Available A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info 6.04. Como principal resultado encontrou-se a maior ocorrência de acidentes de trabalho com material biológico entre os profissionais técnicos em enfermagem do sexo feminino (38,6%, com idade de 21 a 30 anos (53,9%. A maioria dos acidentes aconteceu através de lesões com perfurocortantes (82,2%, sendo 24,1% no Centro Cirúrgico e 84,5% envolvendo sangue. Conclui-se que o estudo é de extrema relevância, pois, com base no reconhecimento do tipo de acidentes mais frequentes, pode-se conhecer os riscos existentes e intervir na sua redução, por meio de ações preventivas que beneficiem o trabalhador e a instituição.El estudio aborda la exposición ocupacional a material biológico a que fueron sometidos los profesionales de salud en el Hospital Santa Casa de Misericordia de Pelotas, de enero de 2004 a junio de 2008. Este es un corte transversal, descriptivo y cuantitativo. Se utiliza como herramienta de investigación un cuestionario basado en el formulario de informe de accidente de trabajo de esa institución. Los datos fueron introducidos y analizados con Epi-Info 6.04. Como principal resultado se encontró una mayor incidencia de accidentes con material biológico entre los profesionales técnicos de enfermería del sexo femenino (38,6%, de 21 años a 30 años (53,9%. La mayoría de los accidentes ocurrió a través de lesiones con objetos punzantes (82,2%, siendo que 24,1% ocurrió en el Centro Quirúrgico, y 84,5% con sangre. Se

  17. Topografía medieval de la casa toledana de los Laso de la Vega en la parroquia de San Román

    Directory of Open Access Journals (Sweden)

    Passini, Jean

    2008-06-01

    Full Text Available This article reveals the evolution of the medieval houses that were successively of the bishop don Vasco Ramirez de Rivera (1480-1492 and of Laso de la Vega family (1491-1616. It draws from various medieval documentary sources particularly of the Mercy’s Hospital. This article examines also some actual houses of san Roma’s hill. It proposes a plan of the houses at the end of the 15th century and the situation of the native house of the poet Garcilaso.Los documentos medievales del Archivo del Hospital de la Misericordia favorecen la reconstitución de la evolución de una manzana, en la parroquia de san Román donde se elevaban las casas mayores que fueron sucesivamente del obispo de Coria, don Vasco Ramírez de Rivera y de la familia de los Laso de la Vega. Aunque esta casa ha sufrido varias transformaciones hasta su destrucción en el siglo XX, el autor ha podido restituirla al final del siglo XV, usando el estudio del parcelario, y situar la casa donde nació el poeta Garcilaso.

  18. Prueba comparativa de uniformidad de contenido en tabletas de teofilina (150 mg/tab de dos casas farmacéuticas en Costa Rica

    Directory of Open Access Journals (Sweden)

    Esteban Pérez-López

    2014-05-01

    Full Text Available Dada la importancia del medicamento denominado teofilina para su uso en pacientes con problemas de asma y su alto consumo en Costa Rica, se eligió el producto en tabletas de 150 mg de teofilina de una casa farmacéutica que lo produce y distribuye en forma genérica, junto con el que fabrica la Caja Costarricense de Seguro Social (CCSS en la misma dosis. Se realizó el estudio comparativo de la prueba de uniformidad de contenido para las tabletas de teofilina de 150 mg de la casa farmacéutica LISAN y las fabricadas por la CCSS. La prueba de uniformidad de contenido analíticamente se fundamentó en la absorción y cuantificación del ingrediente activo teofilina a 272 nm para 10 muestras de cada casa farmacéutica, mediante el uso de un espectrofotómetro UV/Vis, empleando como disolvente agua destilada. Se probó un método selectivo, exacto y preciso y se obtuvo como resultado que todas las dosis ensayadas para cada fabricante se encuentran en el rango de 100% a 110%, con respecto a lo etiquetado sobre el principio activo en las tabletas y con un desvío relativo no mayor al 2,5%, cumpliendo holgadamente con lo establecido por la Farmacopea de Estados Unidos para la prueba de uniformidad de contenido.

  19. A Casa Grande de Romarigães, um legado arquitectónico e literário de Aquilino Ribeiro

    Directory of Open Access Journals (Sweden)

    Maria Ribeiro Machado Pedroso de Lima

    2017-12-01

    Full Text Available A Casa Grande de Romarigães terá servido de cenário literário a uma das mais simbólicas obras do escritor Aquilino Ribeiro: A casa grande de Romarigães. Sua estrutura arquitectónica foi classificada como Imóvel de Interesse Público em 1986, atribuição que ainda não derivou em nenhum estudo rigoroso sobre a sua evolução morfológica. Com base nas constantes descrições na obra de Aquilino Ribeiro, e do seu confronto com a documentação histórica entretanto encontrada (escrita e gráfica, em grande parte inédita, este trabalho de investigação propõe o desenho da evolução morfológica da casa ao longo dos tempos, bem como a enunciação da influência deste solar para a organização social, cultural e económica da aldeia de Romarigães.

  20. CAPACITAÇÃO DE ENFERMEIRAS NO JAPÃO: CONTRIBUIÇÃO PARA A IMPLANTAÇÃO DA CASA DE PARTO NO RIO DE JANEIRO

    Directory of Open Access Journals (Sweden)

    Jane Márcia Progianti

    2013-01-01

    Full Text Available Estudio cualitativo histórico-social que discute las contribuciones de la capacitación de las enfermeras obstetras brasileñas en los centros de parto normales japoneses para la implantación de la Casa de Parto en Rio de Janeiro-RJ, en 2003. Las fuentes son documentos escritos y orales obtenidos en acervos y a través de entrevista semi-estructurada. Las etapas del análisis: ordenación, clasificación y triangulación de los datos. Para basar el análisis se utilizaron los conceptos de campo, habitus, poder simbólico y capital. Los resultados revelaron que la capacitación de las enfermeras obstétricas en el Curso de Asistencia al Parto en las Casas de Parto de Japón fue una estrategia del Gobierno Federal para reconfigurar el campo obstétrico que actualizó en habitus de estas enfermeras. Las dos enfermeras propuestas por la Secretaría Municipal de Sanidad-RJ al regreso del curso de formación ocuparon cargos institucionales que viabilizaron el funcionamiento de la Casa de Parto.

  1. Parentesco y casas en un barrio de bajos ingresos asistido por el Programa de Salud Familiar en Salvador, Bahía, Brasil

    Directory of Open Access Journals (Sweden)

    Vania Bustamante

    2011-01-01

    Full Text Available En este trabajo se analiza la construcción cotidiana del parentesco en un barrio de bajos ingresos de Salvador atendido por el Programa de Salud Familiar (PSF. Fueron realizadas entrevistas y observación participante durante tres años de trabajo de campo. Encontramos que el parentesco se construye permanentemente en base a vínculos de "sangre" y de "consideración". Mostramos la comprensión que los informantes tienen sobre sus "casas" y la relación entre la "configuración de las casas" y la construcción de las relaciones de parentesco de hombres y mujeres. Analizamos cómo estas relaciones son producidas en intercambios que involucran también cuidados de salud. Reflexionamos sobre los contrastes entre la propuesta formal del PSF ¿que establece equivalencia entre casa y familia y enfoca sobre la conyugalidad¿ y lo que observamos en esta investigación. A partir de eso pensamos sobre los desafíos que la implantación del mencionado programa origina, especialmente para el trabajo de los profesionales de la salud.

  2. Expression Analysis of p16, c-Myc, and mSin3A in Non-small Cell Lung Cancer by Computer Aided Scoring and Analysis (CASA).

    Science.gov (United States)

    Salmaninejad, Arash; Estiar, Mehrdad Asghari; Gill, Rajbir K; Shih, Joanna H; Hewitt, Stephen; Jeon, Hyo-Sung; Fukuoka, Junya; Shilo, Konstantin; Shakoori, Abbas; Jen, Jin

    2015-01-01

    Immunohistochemical analysis (IHC) of tissue microarray (TMA) slides enables large sets of tissue samples to be analyzed simultaneously on a single slide. However, manual evaluation of small cores on a TMA slide is time consuming and error prone. We describe a computer aided scoring and analysis (CASA) method to allow facile and reliable scoring of IHC staining using TMA containing 300 non-small cell lung cancer (NSCLC) cases. In the two previous published papers utilizing our TMA slides of lung cancer we examined 18 proteins involved in the chromatin machinery. We developed our study using more proteins of the chromatin complex and several transcription factors that facilitate the chromatin machinery. Then, a total of 78 antibodies were evaluated by CASA to derive a normalized intensity value that correlated with the overall staining status of the targeting protein. The intensity values for TMA cores were then examined for association to clinical variables and predictive significance individually and with other factors. RESULTs: Using our TMA, the intensity of several protein pairs were significantly correlated with an increased risk of death in NSCLC. These included c-Myc with p16, mSin3A with p16 and c-Myc with mSinA. Predictive values of these pairs remained significant when evaluated based on standard IHC scores. Our results demonstrate the usefulness of CASA as a valuable tool for systematic assessment of TMA slides to identify potential predictive biomarkers using a large set of primary human tissues.

  3. French Presence in Brazil in the Nineteenth Century: analysis of the accounting archives of Casa Boris’s in the period from 1872 to 1887

    Directory of Open Access Journals (Sweden)

    José Paulo Cosenza

    2014-09-01

    Full Text Available Founded in Brazilian imperial period, Casa Boris had an important commercial role in the Northeast region of Brazil. Using a competitive business structure, it linked the Ceará Province (branch with France (headquarters, by importing manufactured goods and exporting raw materials. In this paper, we studied the Journal and Ledger of Casa Boris, particularly from 1872 to 1887. The study aimed to analyze the contents of the accounting records contained in these books so as to report facts and points of historical interest to the Brazilian Accounting. The main contribution of the research, in general, is associated with an attempt to understand the influence of political, economic, social and institutional settings on accounting practices and vice-versa. Our findings led to the conclusion that the bookkeeping of Casa Boris was transparent to reveal the quality of accounting control of commercial operations undertaken by the firm and also shows the coexistence of a incipient provincial market that concomitantly linked Brazil to Europe in the second period of Brazilian Monarchical Empire.

  4. Rates for some reactions involving 42Ca and 44Ca

    International Nuclear Information System (INIS)

    Cheng, C.W.; King, J.D.

    1980-01-01

    Ground-state reaction rates have been deduced from recent cross section measurements for the 42 CA(α, n) 45 Ti, 42 Ca(p, γ) 43 Sc, and 44 Ca(p, n) 44 Sc reactions. Comparison of these rates with those calculated from a statistical model of nuclear reactions. (Woosley et al) shows good agreement for the first two, but the 44 Ca(p, n) rate is more than a factor of 2 less than the theoretical prediction. Stellar reaction rates have been derived from the ground-state rates by multiplying the ground-state rates by the ratio of stellar to ground-state rates given by the statistical model. Both ground-state and stellar rates have been represented by analytic functions of the temperature. The role of these reactions in the approach to quasi-equilibrium during explosive silicon burning is discussed

  5. La conciencia atormentada de un monstruo abandonado "La casa de Asterión", Jorge Luis Borges

    Directory of Open Access Journals (Sweden)

    Luis Quintana Tejera

    2011-01-01

    Full Text Available El enfoque del presente ensayo ofrece como eje central la personalidad y acciones del protagonista de "La casa de Asterión". Este cuento se halla incardinado en el libro El Aleph. Cuando el Minotauro nos cuenta su vida, observaremos de qué manera su voz se vuelve desconsolada y provoca lástima en el lector. Analizaremos el título, el epígrafe y la historia central o diégesis, se reservará un lugar también para reflexionar en torno a lo que hemos denominado como "metadiégesis implícitas". Las nociones de conocimiento y aprendizaje ocuparán un lugar destacado en nuestro análisis, siempre en relación con la voz que narra los acontecimientos. Por último, serán revisados también los modos de focalización -vía Gérard Genette- que se ofrecen en el relato.

  6. [Association between indoor contamination and respiratory diseases in children living in Temuco and Padre Las Casas, Chile].

    Science.gov (United States)

    Rivas R, Edith; Barrios C, Sara; Dorner P, Anita; Osorio S, Ximena

    2008-06-01

    Indoor air pollution, is the main cause of population exposure to polluting agents. To establish an environmental profile of indoor contamination emission sources in families of children under 5 years that assist to kindergartens in Temuco and Padre Las Casas. To associate respiratory disease episodes in children with indoor contamination. Cross sectional analysis of 355 family groups subjected to questionnaires about indoor contamination and number of respiratory disease episodes. Forty six percent of mothers or caregivers smoked, 37% smoked at home and 93% smoked one to two cigarettes per day. There was a significant association between respiratory diseases in children and drying clothes in the kitchen, using firewood for heating and the presence of humidity in the dwelling. Mothers identified as indoor contaminants the use of braziers in 76% of cases and firewood stoves in 24%. Ninety seven percent considered that these appliances were detrimental for respiratory health. The lack of awareness about indoor contamination among subjects of low socioeconomic status should prompt educational campaigns to modify behaviors in their dwellings.

  7. Casa da qualidade e qualidade da informação: revisão sistemática

    Directory of Open Access Journals (Sweden)

    Fernanda dos Santos

    Full Text Available RESUMO As informações são consideradas matéria-prima para criação de conhecimento, este que por sua vez agrega valor às organizações, proporciona inovação e dá destaque para as organizações. Para que as organizações se mantenham competitivas na Era do Conhecimento, é necessário que tenham atenção à qualidade da informação estratégica, buscando formas de avaliá-las, proporcionando, por consequência, maior assertividade nas tomadas de decisão. Com isso, esta pesquisa buscou através de uma revisão sistemática de literatura compreender de que forma a Casa da Qualidade, matriz do método QFD (Quality Function Deployment tem interagido com a qualidade da informação. Embora com poucas pesquisas ainda relatando esta interação, o método QFD, um dos métodos trabalhados na gestão da qualidade total, mostra-se como uma ferramenta que pode auxiliar as organizações na avaliação da qualidade da informação organizacional através de adaptações de sua versão original.

  8. MATERIAIS COMPÓSITOS À BASE DE GESSO E ISOPOR PARA CONSTRUÇÃO DE CASAS POPULARES

    Directory of Open Access Journals (Sweden)

    Miguel Cabral Macedo Neto

    2011-12-01

    Full Text Available A utilização de novas tecnologias com o uso materiais alternativos, que são ecologicamente corretos, é uma inovação para indústria da construção civil não só pelas suas excelentes propriedades, mas também pelo barateamento na construção. Esse artigo visa expor um novo tipo de material compósito para construção de casas populares de baixo custo, à base de isopor (poliestireno e gesso, que possui composições (1.5:1, (1:1,(1:1,5 gesso com isopor, a fim de substituir os tijolos tradicionais de cerâmicos convencionalmente utilizados. Dados relativos aos ensaios de condutividade térmica e de compressão foram realizados. Foi demonstrado que o custo de fabricação desses tijolos alternativos é inferior ao do tijolo convencionalmente utilizado além de apresentarem excelente resistência.

  9. Métodos para determinar las casas del horóscopo en la astrología

    Directory of Open Access Journals (Sweden)

    Casulleras, Josep

    2009-06-01

    Full Text Available This paper revises the different methods of computation devised by Medieval Arabic astronomers and mathematicians for the astrological practice of the division of houses. Starting from a classification of these methods established by J.D. North (1986 and extended by E.S. Kennedy (1996, I summarize the available information contained in previous studies and present new data emerging from the analysis of more recently explored sources, emphasizing certain features of a Western astrological tradition.

    Este trabajo repasa los distintos métodos de cálculo que los astrónomos y matemáticos árabes medievales desarrollaron para ser aplicados a la práctica astrológica de la división de casas. Partiendo de una clasificación de estos métodos establecida por J.D. North (1986 y ampliada por E.S. Kennedy (1996, se recoge la información que se halla en estudios anteriores y se presentan nuevos datos como resultado del análisis de fuentes exploradas más recientemente, destacando ciertos elementos pertenecientes a una tradición astrológica occcidental.

  10. Profile of Heart Donors from the Human Valve Bank of the Santa Casa de Misericórdia de Curitiba.

    Science.gov (United States)

    Ferreira, Renata Maria; da Costa, Marise Teresinha Brenner Affonso; Canciglieri Junior, Osiris; Sant'Anna, Ângelo Márcio Oliveira

    2016-04-01

    Human heart valves are used as replacement valves and have satisfactory functional results compared with conventional prostheses. Characterize the profile of effective heart donors from the human valve bank of the santa casa de misericórdia de curitiba and analyze the association between the profile variables. It consists of a retrospective and quantitative study of electronic medical records from heart donors for heart valves. every heart donation made to the bank between january 2004 and december 2014 was studied. 2,149 donations were analyzed, from donors aged 0 to 71 years old, with an average of 34.9 ± 15.03 years old. most donors were male 65.7% (n=1,411) and 34.3% (n=738) were female. among the most frequent causes of the donors' death are trauma at 53% (n=1,139) and cerebral vascular accident at 34.2% (n=735). there was significant statistical association between the analyzed variables. There has been an improvement in brazil's donation rate, being essential that the tissue banks work together with the state and federal district centers for notification, procurement and distribution of organs in order to increase the number of donors.

  11. Bloodmeal Identification in Field-Collected Sand Flies From Casa Branca, Brazil, Using the Cytochrome b PCR Method.

    Science.gov (United States)

    Carvalho, G M L; Rêgo, F D; Tanure, A; Silva, A C P; Dias, T A; Paz, G F; Andrade Filho, J D

    2017-07-01

    PCR-based identification of vertebrate host bloodmeals has been performed on several vectors species with success. In the present study, we used a previously published PCR protocol followed by DNA sequencing based on primers designed from multiple alignments of the mitochondrial cytochrome b gene used to identify avian and mammalian hosts of various hematophagous vectors. The amplification of a fragment encoding a 359 bp sequence of the Cyt b gene yielded recognized amplification products in 192 female sand flies (53%), from a total of 362 females analyzed. In the study area of Casa Branca, Brazil, blood-engorged female sand flies such as Lutzomyia longipalpis (Lutz & Neiva, 1912), Migonemyia migonei (França, 1924), and Nyssomyia whitmani (Antunes & Coutinho, 1939) were analyzed for bloodmeal sources. The PCR-based method identified human, dog, chicken, and domestic rat blood sources. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. Palynological analysis of camelid coprolites: seasonality in the use of the site Cerro Casa de Piedra 7 (Santa Cruz, Argentina)

    Science.gov (United States)

    Velázquez, Nadia Jimena; Burry, Lidia Susana; Fugassa, Martín Horacio; Civalero, María Teresa; Aschero, Carlos Alberto

    2014-01-01

    Palynological, palaeoparasitological and paleobotanical studies of coprolites found in archaeological sites from Perito Moreno National Park (47°57‧S72°05‧W) yielded information on diet, palaeoenvironment and health. These studies allowed adding evidence to the reconstruction of life history of the hunter-gatherers that inhabited Patagonia during the Holocene. We examined the season of the year when camelid Lama guanicoe coprolites (5400 ± 64 yr 14C BP to 9640 ± 190 yr 14C BP) were deposited at Cerro Casa de Piedra 7 (site CCP7). The study used palynological evidence and comparison with pollen spectra of modern feces collected during summer, fall, winter and spring of 2010. The dominant types were: pollen of Nothofagus, Empetrum rubrum, Asteraceae subfam. Asteroideae, Nassauvia, Caryophyllaceae and Poaceae; fern spores; remains of Eimeria macusaniensis; and plant remains of Poaceae, Festuca pallescens, Stipa speciosa, Armeria maritima, Gaultheria mucronata and E. rubrum. Pollen spectra of modern and fossil feces were used for multivariate analysis. Coprolites associated to fall and winter modern feces. These results and those obtained from pollen concentration values and the presence of pollen types indicators of seasonality, allowed the determination of summer, fall and winter coprolites. However, caution must be taken with the seasonality results of coprolites dated earlier than 9000 years BP since the environmental conditions differed from now. The site was probably a camelid shelter during the unfavorable seasons.

  13. O impacto do Programa Minha Casa, Minha Vida na economia brasileira: uma análise de insumo-produto

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Gonçalves Junior

    Full Text Available O objetivo do presente artigo foi analisar o impacto do Programa Habitacional Minha Casa, Minha Vida na economia brasileira mediante a dinamização do setor da construção civil, utilizando a matriz de insumo-produto de 2008 para estimação dos geradores e multiplicadores de produção, renda, emprego e impostos. Os resultados mostraram que o setor da construção civil apresentou ligações para trás e para frente abaixo da média dos setores da economia. No entanto, considerando o valor de R$ 125,7 bilhões previstos para investimento no período em análise, constatou-se que haverá crescimento significativo na renda paga aos trabalhadores, serão criados cerca de 7 milhões de empregos diretos e indiretos, haverá aumento na produção de cerca de 6% do PIB em valores de 2010, e pelo menos 16% do valor dos subsídios dados nos contratos de financiamento do PMCMV voltarão aos cofres públicos.

  14. Lifestyle entrepreneurs, hostels and backpacker tourism development: the case of San Cristóbal de las Casas, Mexico

    Directory of Open Access Journals (Sweden)

    Ludger Brenner

    2016-01-01

    Full Text Available Partiendo del concepto del empresario de estilo de vida (lifestlye entrepreneur, este artículo analiza los motivos, objetivos y estratégicas comerciales de este grupo para establecer y gestionar "hostales mochileros" en San Cristóbal de las Casas. Así, tratamos caracterizar y analizar a actores calves que impulsan el desarrollo de esta forma de turismo poco investigada hasta la fecha. Con base en 27 entrevistas a profundidad con propietarios y gerentes, se concluye que los empresarios de estilo de vida tratan de satisfacer la demanda de los mochileros contemporáneos, creando un ambiente específico y marcando distancias con competidores orientados principalmente hacía el lucro. Asimismo, los propietarios aspiran a sostener un estilo de vida claramente hedonístico y perpetuar su estatus de mochileros "sénior", ofreciendo servicios especiales y difíciles de imitar. Al mismo tiempo, los empresarios de estilo de vida han desarrollado estrategias para lidiar con la creciente competencia y con las preferencias cambiantes de sus clientes.

  15. Estrabismo paralítico: revisão de 24 anos da Santa Casa de São Paulo Paralytic strabismus: review of 24 years at "Santa Casa de São Paulo"

    Directory of Open Access Journals (Sweden)

    Gustavo Bueno de Camargo

    2007-08-01

    Full Text Available OBJETIVO: Avaliar a incidência, etiologia e evolução dos estrabismos paralíticos ou paréticos. MÉTODOS: Foram selecionados retrospectivamente 519 prontuários de pacientes com paresia ou paralisia isolada dos músculos inervados pelos III, IV ou VI nervos cranianos, a partir de 11.000 prontuários da Seção de Motilidade Extrínseca Ocular do Departamento de Oftalmologia da Santa Casa de São Paulo de janeiro de 1980 a outubro de 2004. Foram estudados: o nervo craniano acometido, o olho acometido, o sexo, os fatores etiológicos e a evolução desses pacientes. RESULTADOS: Dos 519 pacientes, 17,1% foram casos congênitos e 82,9% foram adquiridos. O nervo craniano mais afetado foi o VI (49,7%. Os pacientes do sexo masculino foram mais acometidos, com 58,1% dos casos. A etiologia traumática foi a mais freqüente nos casos de paresia ou paralisia de III (43,0%, IV (52,4% e VI (48,8% nervos cranianos. Os pacientes evoluíram mais freqüentemente para cirurgia nos três grupos: III nervo (42,9%, IV nervo (73,2% e VI nervo (43,2%. CONCLUSÃO: O VI nervo craniano foi o mais freqüentemente acometido e o fator etiológico mais importante foi o traumatismo, dados esses que coincidem com os encontrados na literatura.PURPOSE: To describe the incidence, etiologies and follow-up of patients with paralytic strabismus. METHODS: Retrospective study of 519 strabismic patients with isolated III, IV or VI cranial nerve palsy of 11,000 charts of the Ocular Motility Section of the Department of Ophthalmology of "Faculdade de Ciências Médicas Santa Casa de São Paulo", Brazil, between January 1980 and October 2004. This study analyzed: the injured cranial nerve, affected eye, sex distribution, etiology and follow-up. RESULTS: It was found that 17.1% of the cases were congenital and 82.9% acquired. The VI cranial nerve was the most frequently affected (49.7%. The incidence was higher in males (58.1%. Traumatism was the most common cause of III (43.0%, IV (52

  16. Filamentous fungi isolated from sand and water of "Bairro Novo" and "Casa Caiada" beaches, Olinda, Pernambuco, Brazil Fungos filamentosos isolados do solo e da água nas praias de Bairro Novo e Casa Caiada, Olinda, Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    DNF. Gomes

    2008-08-01

    Full Text Available Fungi comprehend a heterogeneous group of heterotrophic microorganisms that act as saprobes or parasites or, less frequently, as symbionts living in association with other organisms. They are cosmopolitan and important components of ecosystems. Considering the small number of Brazilian papers on the filamentous mycota in marine environments, and the need to improve knowledge of the diversity of these microfungi in "Casa Caiada" and "Bairro Novo" beaches, Olinda, PE, the aim of this work was to isolate and identify the fungi from sand and water samples of these ecosystems. Thirty two samplings of sand (surface and 20 cm deep and water (surface and 1 m deep were carried out during the dry and rainy seasons, in low and high tide. From each sand sample, a suspension was made with 50 g of sand diluted in 90 mL of sterilized distilled water. From each sand suspension and water sample, 0.5 mL was spread, in triplicate, onto Petri dishes containing Sabouraud Agar added of chloramphenicol. The plates were incubated at 28 °C (±2 °C. Fifty seven species were isolated, identified, and classified in 20 genera. Aspergillus and Penicillium were the most frequent genera in both sand and water, with a total of 11 and 19 species, respectively.Os fungos compreendem um grupo heterogêneo de microorganismos heterotróficos, atuando como sapróbios ou parasitas, ou menos freqüentemente como simbiontes, vivendo em associação com outros organismos. São cosmopolitas e componentes importantes dos ecossistemas. Considerando-se a escassez de trabalhos no Brasil que tratam da micota filamentosa em ambientes marinhos, e ainda a necessidade do conhecimento da diversidade desses microfungos nas praias de Casa Caiada e Bairro Novo, Olinda, PE, este trabalho teve como objetivo o isolamento e identificação de fungos, em amostras de solo e de água, desses ecossistemas. Foram realizadas 32 coletas do solo (em superfície e a 20 cm de profundidade e da água (em superf

  17. Jurisdicción y solar. Poder, rentas y patrimonio de la casa de Grajal en la Edad Moderna

    Directory of Open Access Journals (Sweden)

    Laureano M. RUBIO PÉREZ

    2009-12-01

    Full Text Available RESUMEN: El presente artículo se enmarca en un proyecto más amplio que centrado en los señoríos y en el régimen señorial del Reino de León pretende profundizar tanto en el conocimiento de las diferentes casas nobiliarias, como en la incidencia que su dominio señorial tuvo en el desarrollo histórico y en el conjunto social de las comunidades concejiles leonesas sobre las que imponen su poder jurisdiccional. A partir de una serie de datos cuantitativos y de la información ofrecida por la documentación notarial hemos podido conocer tanto la dinámica familiar y el patrimonio de la Casa de Grajal, como la tipología y el nivel de ingresos procedentes de las rentas de los diferentes mayorazgos que ostentaron los señores, posteriormente condes de Grajal, hasta su incorporación en el siglo XVIII al marquesado de Alcañices. Dos rasgos fundamentales aparecen como definidores de un modelo de señorío en el que determinadas rentas feudales se intentan disfrazar bajo la cobertura de un supuesto dominio territorial cuya titularidad es difícil de probar fuera del feudo: los fueros concejiles que, sobre la base de antiguos censos de frutos, se convierten en foros enfitéuticos colectivos y la confrontación entre un poder señorial jurisdiccional y el poder político concejil que sobre la base del derecho consuetudinario se mantiene aún fuerte en el seno de estas villas rurales y que en cierto modo justifica la acción colectiva ante los frecuentes conflictos antiseñoriales.ABSTRACT: This work is part of a wider Project focussed on fiefs and feudal regime in the kingdom of Leon, that tries to enhance our knowledge of both the different noble houses and the influence that their lordship had in the historical and social development of the communities ruled by councils {Concejos, over which they exercised jurisdictional powers. Thanks to a series of quantitative data and to the information obtained from the records of notaries, we have grasped

  18. Estimation Terrestrial Net Primary Productivity Based on CASA Model: a Case Study in Minnan Urban Agglomeration, China

    International Nuclear Information System (INIS)

    Hua, L Z; Liu, H; Zhang, X L; Zheng, Y; Man, W; Yin, K

    2014-01-01

    Net Primary Productivity (NPP) is a key component of the terrestrial carbon cycle. The research of net primary productivity will help in understanding the amount of carbon fixed by terrestrial vegetation and its influencing factors. Model simulation is considered as a cost-effective and time-efficient method for the estimation of regional and global NPP. In the paper, a terrestrial biosphere model, CASA (Carnegie Ames Stanford Approach), was applied to estimate monthly NPP in Minnan urban agglomeration (i.e. Xiamen, Zhangzhou and Quanzhou cities) of Fujian province, China, in 2009 and 2010, by incorporating satellite observation of SPOT Vegetation NDVI data together with other climatic parameters and landuse map. The model estimates average annual terrestrial NPP of Minnan area as 16.3 million Mg C. NPP decreased from southwest to the northeast. The higher NPP values exceeding 720 gC·m − 2 ·a −1 showed in North Zhangzhou city and lower values under 500 gC·m − 2 ·a −1 showed in the some areas of northeast Quanzhou city. Seasonal variations of NPP were large. It was about 45% of the total annual NPP in the three months in summer, and the NPP values were very low in winter. From 2009 to 2010, the value of annual NPP showed a slightly decrease trend, approximately 7.8% because the annual temperature for 2010 decline 13.6% compared with 2009 in despite of an increase in rainfall of about 34.3%. The results indicate that temperature was a main limiting factor on vegetation growth, but water is not a limiting factor in the rainy area

  19. CaWingz user's guide

    International Nuclear Information System (INIS)

    Cha, Ben-chin.

    1994-01-01

    This document assumes that you have read and understood the Wingz user's manuals. CaWingz is an external Wingz program which, when combined with a set of script files, provides easy-to-use EPICS channel access interface functions for Wingz users. The external function run allows Wingz user to invoke any Unix processor within caWingz. Few additional functions for accessing static database field and monitoring of value change event is available for EPICS users after release 3.11. The functions, script files, and usage are briefly described in this document. The script files supplied here serve as examples only. Users are responsible for generating their own spreadsheet and script files. CaWingz communicates with IOC through channel access function calls

  20. Experiências educacionais no século xvi: a formação da casa de meninos de são paulo de piratininga

    Directory of Open Access Journals (Sweden)

    Felipe Ziotti Narita

    2007-12-01

    Full Text Available Este estudo pretende analisar as atividades educacionais jesuíticas desenvolvidas na Casa de Meninos de São Paulo de Piratininga, localizada no interior da capitania de São Vicente, entre 1554 e 1556: período que contou com a participação direta do jesuíta Manuel da Nóbrega e que compreende as primeiras experiências pedagógicas vivenciadas na constituição daquele núcleo de ensino. Para tanto, a pesquisa voltou-se à análise de cartas escritas por jesuítas, durante o recorte temporal proposto, que relatam as atividades educacionais ministradas inicialmente e as condições sob as quais se desenvolveram a educação e a formação religiosa dos indígenas na Casa de Meninos de São Paulo de Piratininga. Com o cultivo de um modelo pedagógico indissociável da formação educacional na religião, os jesuítas estruturaram uma cultura escolar que encontrou respaldo nos métodos catequéticos da Companhia. Assim, embora afetado pela precariedade material e pelos infortúnios, o sistema de ensino e de formação religiosa jesuítico da Casa de Meninos fomentou as bases para a fixação de um povoado em São Paulo de Piratininga.

  1. Acompanhamento do sistema de gestão de segurança alimentar (ISO 22000:2005) na Cevadas - Casa das Carnes do Ervedal

    OpenAIRE

    Silva, Joana Andreia Cavaleiro

    2015-01-01

    RESUMO A Cevadas – Casa das Carnes do Ervedal, é uma empresa de origem familiar com sede numa localidade denominada Ervedal, que pertence à freguesia de Quiaios e ao concelho da Figueira da Foz. Tem uma experiência de mais de 30 anos na produção de enchidos tradicionais, pelo que ao longo dos anos foi sujeita a uma grande evolução em termos de desenvolvimento de novas infraestruturas e conquista de novos mercados com a apresentação de novos produtos e soluções. A realização do meu estágio...

  2. Plan de negocio para la creación de una casa rural casitas El Teu-Llar en la isla de Lanzarote

    OpenAIRE

    GONZALEZ JARA, MARIA CRISTINA

    2014-01-01

    [ES] El presente trabajo final de carrera tiene por objeto la realización de un plan de negocio para implantar una empresa dedicada al alojamiento rural en el municipio de Haría (Lanzarote). El nombre comercial de la misma será Casitas el Teu-Llar queriendo hacer presente en el nombre tanto la procedencia de la propietaria (Valencia) como el lema de la empresa que es sentirse en casa. Los servicios que proporcionará estarán divididos en tres líneas de negocio (alojamiento, restauración y ...

  3. Desenvolvimento e avaliação de painéis de argamassa armada para aplicação em casas de agrovilas

    OpenAIRE

    Oliveira, Rui Carlos de

    2013-01-01

    A agricultura brasileira vem se transformando, com grandes estruturas agroindustriais, melhor aproveitamento do espaço físico e melhor uso dos recursos disponíveis, e o trabalhador rural tem preferido morar próximo do local de trabalho, que normalmente são agrovilas. Estas localidades demandam casas com execução simples, rápida e econômica, como as edificações moduladas, confeccionadas com painéis pré-fabricados, com redução do tempo de montagem sobre fundações prontas e redução significativa...

  4. Identidad cultural y paisaje construido. Proyecto piloto para la restauración de casas tradicionales en el Rincón de Ademuz (Valencia

    Directory of Open Access Journals (Sweden)

    Fernando Vegas

    2005-12-01

    Full Text Available La distinción otorgada en la última convocatoria de los premios Europa Nostra 2003 a un proyecto piloto para la recuperación de las casas tradicionales de una comarca valenciana remota e ignorada, ha elevado el patrimonio de la arquitectura vernácula a la misma cota de valoración que otros grandes monumentos europeos. A continuación, se presentan los antecedentes, planteamiento general del proyecto premiado, soluciones concretas, viabilidad económica y primeras acciones de restauración emprendidas en la rehabilitación de esta arquitectura planteada desde su propia esencia constructiva y estructural.

  5. Paremiología y refranes de la Casa de Caritat de Barcelona, desde el punto de vista de la Pragmática

    OpenAIRE

    Laborda Gil, Xavier

    2004-01-01

    This paper gathers a collection of proverbs set as an ornamental motif at the old “Casa de Cartitat” (the Charity House, in Barcelona) and analyzes its contents from a pragmatic point of view. The house was one of the main charitable city organization in the 19th century. The collection consists of nineteen proverbs, written in Catalan and set by means of glazed tiles on the walls of the women's courtyard of the Charity House. To set an example, one of this proverbs says: “Sempre ...

  6. ostulaciones políticas en la novela colombiana La casa de las dos palmas, del escritor Manuel Mejía Vallejo

    OpenAIRE

    Sandoval, Liliana Andrea; Sierra, Claudia Marcela

    2011-01-01

    Este artículo está basado en la investigación titulada “Postulaciones políticas en la novela colombiana del siglo XX” de la Universidad Cooperativa de Colombia, sede Bucaramanga, 2009, que consta de tres apartados: la triple mimesis de Ricoeur en Tiempo y narración, análisis del entorno del autor y difusión de su obra en los ambientes escolares.La novela La casa de las dos palmas de Manuel Mejía hace un recuento de la realidad sociopolítica del momento, el machismo marcado y el sometimiento d...

  7. Salida de campo a la casa forestal ubicada en el pico Caimodorro (Orihuela del Tremedal, Teruel) el 16 y 17 de julio de 1952

    OpenAIRE

    Valverde Gómez, José Antonio, 1926-2003

    2008-01-01

    Salida de campo del autor y Francisco Bernis a la casa forestal ubicada en el pico Caimodorro (Orihuela del Tremedal, Teruel), el 16 y 17 de julio de 1952, de la que se anotaron observaciones sobre lagartijas, los mamíferos Martes foina (Garduña) y Microtus sp. (Topillo), y las siguientes aves: Accipiter nisus (Gavilán común, también llamado Astur palumbarius por el autor), A.citrinella, Buteo buteo (Busardo ratonero, también llamado Águila ratera), Carduelis cannabina (Pardillo común, llamad...

  8. Amas de casa, televisión y participación política. México, elecciones 2003

    Directory of Open Access Journals (Sweden)

    Aimée Vega Montiel

    2004-01-01

    Full Text Available A través de la metodología de la entrevista y partiendo de las preguntas: ¿cómo ven las amas de casa las noticias televisivas sobre las elecciones?; ¿por qué?; ¿para qué?, la autora analiza la frecuencia con la que este sector de la población femenina ve las noticias electorales en televisión así como la influencia que este medio ejerció sobre el comportamiento político-electoral durante el último proceso electoral en México (julio del 2003.

  9. Socioeconomic residential segregation and public housing policies. An approach from the Program “Mi Casa, Mi Vida”. Case study in the city of Cordoba, Argentina

    Directory of Open Access Journals (Sweden)

    Florencia Molinatti

    2016-07-01

    Full Text Available This paper aims to analyze the possible effects of the housing program “Mi Casa, Mi Vida” in socioeconomic residential segregation in the city of Córdoba (Argentina. These effects are estimated from the study of the socioeconomic residential composition (before and after the implementation of the program, the mapping of residential movements generated by the program and the application of bivariate autocorrelation techniques. Among the key findings, most of the program beneficiaries are concentrated in poor areas surrounded by others in similar conditions. This fact favors the existence of a large cluster of poverty in the peripheries of the city and promotes marginalization and social exclusion.

  10. Estrategia patrimonial y jerarquía del linaje: los mayorazgos de la Casa Ducal de Maqueda en el siglo XVI

    OpenAIRE

    Palencia Herrejón, Juan Ramón

    2002-01-01

    El linaje Cárdenas pasó en corto espacio de tiempo de la segunda fila de la nobleza a la más encumbrada ricahombría castellana gracias a la privanza de Gutierre de Cárdenas con los Reyes Católicos. Una vez constituido el primer mayorazgo, se administró de tal manera el patrimonio vinculado que sirvió no sólo para asentar el poder de la Casa ducal de Maqueda sino también para desarrollar una solidaridad familiar basada en la distribución de bienes entre los miembros de la parentela, una distri...

  11. Fluorescent multiple staining and CASA system to assess boar sperm viability and membranes integrity in short and long-term extenders

    OpenAIRE

    F. Cremonesi; A. Meucci; A. Lange-Consiglio

    2013-01-01

    The aim of this study was to assess the effect on boar spermatozoa quality of in vitro storage in short and long-term extenders by fluorescent multiple staining (FMS) and computer assisted semen analyzer (CASA). Fresh ejaculates from three healthy, sexually mature boars were diluted with equal volumes of six short-term or three long-term commercial extenders and stored at 19?C for 6 days (short-term) or 12 days (long-term). The integrity of spermatozoa membranes was analyzed by FMS using prop...

  12. Asociación entre la frecuencia de comer fuera de casa y la calidad de hidratos de carbono y de grasas

    OpenAIRE

    Villacís Dueñas, Cecilia Carolina

    2014-01-01

    El objetivo del presente estudio fue investigar la asociación entre la frecuencia de comidas fuera de casa (CFC) con a) calidad de hidratos de carbono y b) la calidad de grasas. Se evaluaron 19.371 participantes de la cohorte SUN que completaron un cuestionario basar de frecuencia de consumo de alimentos previamente validado. Se utilizaron los índices de calidad de hidratos de carbono (ICHC)en una escala de 4 a 20 y de regresión lineal múltiple para determinar la asociación entre la frecuenci...

  13. Weak transitions in 44Ca

    International Nuclear Information System (INIS)

    Tauhata, L.; Marques, A.

    1972-01-01

    Energy levels and gamma radiation transitions of Ca 44 are experimentally determined, mainly the weak transition at 564 KeV and 728 KeV. The decay scheme and the method used (coincidence with Ge-Li detector) are also presented [pt

  14. Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

    International Nuclear Information System (INIS)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

  15. Ca isotopic fractionation patterns in forest ecosystems

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.

    2012-12-01

    Calcium stable isotope ratios are an emerging tracer of the biogeochemical cycle of Ca that are just beginning to see significant application to forest ecosystems. The primary source of isotopic fractionation in these systems is discrimination against light Ca during uptake by plant roots. Cycling of vegetation-fractionated Ca establishes isotopically distinct Ca pools within a forest ecosystem. In some systems, the shallow soil exchangeable Ca pool is isotopically heavy relative to Ca inputs. This has been explained by preferential removal of light Ca from the soil. In other systems, the soil exchange pool is isotopically light relative to inputs, which is explained by recycling of plant-fractionated light Ca back into soil. Thus vegetation uptake of light Ca has been called on to account for both isotopically heavy and light Ca in the shallow soil exchange pools. We interpret patterns in ecosystem δ44Ca with the aid of a simple box model of the forest Ca cycle. We suggest that the δ44Ca of exchangeable Ca in the shallow soil pool primarily reflects the relative magnitude of three key fluxes in a forest Ca cycle, 1) the flux of external Ca into the system via weathering or atmospheric deposition, 2) the uptake flux of Ca from soils into the vegetation pool, and 3) the return flux of Ca to shallow soils via remineralization of leaf litter. Two observations that emerge from our model may aid in the application of Ca isotopes to provide insight into the forest Ca cycle. First, regardless of the magnitude of both vegetation Ca uptake and isotopic fractionation, the δ44Ca of the soil exchange pool will equal the input δ44Ca unless the plant uptake and remineralization fluxes are out of balance. A second observation is that the degree to which the shallow soil exchange pool δ44Ca can differ from the input ratio is controlled by the relative rates of biological uptake and external Ca input. Significant differences between soil exchange and input δ44Ca are seen only

  16. Casa Mariani - Foligno (Italia

    Directory of Open Access Journals (Sweden)

    Antonelli, Franco

    1971-11-01

    Full Text Available This building has been constructed by four brothers, and contains four dwellings, whose distribution, orientation and general design is almost Identical. A basement houses the garage and installations. The ground floor consists mostly of an open space and a porch, and there are two flats per floor on the two top storeys. There is also a lift and a terrace. The building is surrounded on all sides by a garden. The building materials mainly used are unfaced concrete, hand made bricks and timber.Este edificio ha sido construido para cuatro hermanos y contiene otras tantas viviendas de distribución, orientación y composición prácticamente idénticas. El sótano alberga el garaje y los cuartos de instalaciones. La planta baja está formada por el zaguán y el porche. Las dos plantas altas se distribuyen en dos viviendas por planta. La terraza superior y el cuarto de máquinas del ascensor completa el programa exigido. Un amplio jardín rodea el edificio por sus cuatro lados. Materiales esencialmente utilizados: hormigón visto, ladrillo fabricado a mano, y madera.

  17. Casa de un arquitecto

    Directory of Open Access Journals (Sweden)

    Wendell H. Lovett

    2017-06-01

    Full Text Available A diez millas de Seattle, Washington, y en una zona agreste y arbolada, se ha emplazado la colonia "Hilltop Comunity", constituida para asociación de propietarios. Bajo la colaboración de todos, se diseñó la distribución del terreno, carreteras, servicios, localización de viviendas, terrenos de juego, centro comunal...; todo ello con una moderna concepción urbanista, encaminada a resaltar la belleza del lugar.

  18. “Santa Eulalia. Memorias de una Casa Abierta”. (Biografía de Enrique Uribe White

    Directory of Open Access Journals (Sweden)

    Mario Camacho Pinto

    2000-12-01

    Full Text Available

    Desde el comienzo hasta el final de la lectura de este libro, resulta emocionante configurar la reseña sobre su contenido que se refiere a la inusual trayectoria allí descrita de “La Casa de la Tertulia” como la denominó el ex Presidente Belisario Betancur en el inicio del Prólogo, en el que más adelante elogia la forma como “su autor, el médico humanista Efraím Otero- Ruiz, describe su hermoso libro”.

    El autor del libro en su Introducción la denomina “Casa Abierta”, puesto que como lo relata escuetamente, así se mantenía los fines de semana y días festivos, una verdadera “open house” en donde visitantes y amigos podían entrar y salir libremente, todo lo cual es reconstruido con gran fidelidad, en sus propias palabras.

    Enrique Uribe White, hijo de médico y sobrino nada menos que del general Rafael Uribe Uribe, es presentado como descendiente de una racha de antioqueños notables que se lanzaron a colonizar las tierras de Caldas y del Norte del Valle del Cauca, fundando de paso pueblos importantes como Sevilla y Caicedonia. Anota en forma detallada cómo por línea paterna y materna fluyeron los genes que harían de Enrique un intelectual.

    Es admirable el trabajo de investigación, descripción ordenada y detallada sobre la privilegiada vida del personaje que motiva este libro, sobre su formación, educación, instrucción dentro y fuera del país; su inquietud intelectual, su afición por la música, hasta su traslado a Bogotá en plena madurez, que muestra con la fundación de la Revista PAN y el Club Náutico del Muña, y más tarde como Director de la Biblioteca Nacional. Veamos algunos detalles:

    “En su vivienda por el camino hacia Suba le echa el ojo a un lote de la Hacienda Viscaya y lo compra” y construye su exótica mansión que bautizó “Santa Eulalia” en memoria del sitio de donde son originarios sus antepasados viscainos y vascos (Santa Eulalia de Borgoña. “El dise

  19. Programa "Casa das Gestantes": perfil das usuárias e resultados da assistência à saúde materna e perinatal

    Directory of Open Access Journals (Sweden)

    Adriano Marçal Pimenta

    2012-01-01

    Full Text Available Estudio transversal, descriptivo-exploratorio que objetivó caracterizar el perfil y los resultados de atención de salud dada a 820 usuarias de la "Casa de Embarazadas" de una maternidad filantrópica en Belo Horizonte, Minas Gerais, Brasil, entre marzo/2008 y diciembre/2009. Análisis estadística fue basada en presentación de frecuencias absolutas y relativas de variables. Los diagnósticos obstétricos más frecuentes de ingreso fueron relacionados al trabajo de parto prematuro y presión arterial. La mayoría de embarazadas tuvieran alta (44,1% o parto en maternidad tras estabilización de la condición clínica (45,5%; 10,2% agravaran la condición clínica y regresaron al hospital. De los niños, 2,8% tuvieron Apgar a los 5 minutos <7 y, las frecuencias de nacidos muertos y muertes neonatales fueron, respectivamente, 2,6% y 3,5%. Cuidados ofrecidos en la "Casa de Embarazadas" promueven mejora de la condición clínica a la internación y, potencialmente, previne factores que contribuyen para aumentar los índices de mortalidad materna y perinatal.

  20. Estado de salud bucal en la población geriátrica de la casa de abuelos 28 de septiembre

    Directory of Open Access Journals (Sweden)

    Karelia Castro Figueredo

    2015-01-01

    Full Text Available Se realizó un estudio descriptivo transversal en la casa de abuelos “28 de Septiembre”, perteneciente al municipio de Las Tunas, en el periodo de septiembre de 2013 a junio de 2014, con el objetivo de caracterizar el estado de salud bucal de esta población, conformada por los 44 gerontes que asistieron a la referida casa de abuelos en el periodo de estudio. Se evaluaron variables como el nivel de escolaridad, las enfermedades bucales presentes, los factores asociados y el nivel de conocimiento sobre salud bucal. Se utilizaron los porcentajes como medidas de resumen para las variables seleccionadas. El grupo de edad que predominó fue el de 80 y más, la mayor parte de ellos fue del sexo masculino y con primaria terminada. La enfermedad bucal que más abundó fue la caries dental y el factor asociado predominante fue la deficiente higiene bucal. La mayor parte de los pacientes estudiados formó parte del grupo II de los enfermos, según la clasificación epidemiológica. Primaron los pacientes con bajos conocimientos sobre las enfermedades bucodentales

  1. Capilla de la casa de ejercicios de las Hijas de la Caridad de San Vicente de Paúl Barcelona - España

    Directory of Open Access Journals (Sweden)

    Mir Valls, Jorge

    1975-04-01

    Full Text Available Special mention is made in this article of the chapel with oval plan form. It is situated in the bisection of the L-shaped, symmetrically winged body which is the Prayer House. The chapel consists of: basement, with auditorium, ground floor with the actual chapel, vestry and hall; the first floor of the Prayer House communicates directly with the choir. The basic materials are: unfaced concrete, artificial stone and wooden roof, with parabolic tie rods or catenaries, planking, and isolating and waterproofing layers.La capilla, de planta ovalada, es la que se describe especialmente en este artículo. Se halla en la bisectriz del cuerpo en L, de alas simétricas, constituido por la Casa de Ejercicios. Consta de: SEMISOTANO, con salón de actos, y BAJA, con la capilla —propiamente dicha—, sacristía y vestíbulo; desde la PLANTA PRIMERA de la Casa de Ejercicios se accede al coro. Los materiales fundamentales son: hormigón visto, piedra artificial y cubierta de madera, con tirantes o catenarias parabólicas, entablonado y capas aislante e impermeabilizante.

  2. PROGRAMA “CASA DAS GESTANTES”: UMA NOVA LÓGICA DE ATENÇÃO À SAÚDE MATERNA E PERINATAL

    Directory of Open Access Journals (Sweden)

    Adriano Maçal Pimenta

    2010-01-01

    Full Text Available El programa “Casa de las Embarazadas” es una estrategia del Ministerio de Salud Pública BR, teniendo en vista la equidad y humanización de la asistencia a las embarazadas de alto riesgo. Se trata de un estudio epidemiológico, transversal, descriptivo y exploratorio que se realizó en la “Casa de las Embarazadas” de una maternidad filantrópica en Belo Horizonte con el objetivo de evaluar el impacto de este programa en la salud materna de 292 embarazadas que usaron el servicio y de sus recién nacidos (RN. Para tanto, fueran analizados datos del libro de registro de la institución. Los resultados hallados fueron positivos para la salud materna y perinatal: la mejoría clínica de las embarazadas que tuvieron el alta o evolucionaron para el parto en la maternidad y alta proporción de RN con apgar superior a 7. La planificación de la asistencia ofrecida y los índices maternos y perinatales favorables muestran que este programa es una buena estrategia para reducir la mortalidad infantil y materna, Objetivos del Milenio propuestos por la Organización de las Naciones Unidas.

  3. La escultura habitable. La casa de la escultora Mary Callery en Cadaqués. Peter Harnden i Lanfranco Bombelli, 1961

    Directory of Open Access Journals (Sweden)

    Marc Arnal

    2016-10-01

    Full Text Available Peter Harnden y Lanfranco Bombelli eran dos arquitectos que tras la segunda guerra mundial trabajaron para el gobierno de los Estados Unidos de América organizando exposiciones para la divulgación del Plan Marshall desde la embajada americana en París. Tras un viaje a Madrid en el 1956, regresando a la capital francesa hicieron parada, aconsejados por su amigo Coderch, en Cadaqués. En esta población residía Salvador Dalí y pasaría a partir de 1958 los veranos Marcel Duchamp quienes atrajeron a una larga lista de intelectuales y artistas convirtiendo la pequeña población en un centro artístico de primer orden. El lugar y su ambiente cultural sedujeron a los arquitectos que desde 1958 hasta sus respectivas muertes veranearían en esta población. Harnden y Bombelli construirían en Cadaqués nueve casas perfectamente integradas en la arquitectura austera y vernácula del lugar siguiendo los criterios del movimiento moderno. Una de estas fue para la escultora americana amiga de Duchamp, Mary Callery. El artículo analiza esta casa y cómo en ella se aplican los criterios del Arte Concreto, corriente artística a la que estaba afiliado Bombelli.

  4. Cajas vacías para la emoción. Los patios interiorizados de la Casa Carvajal en Somosaguas, Madrid

    Directory of Open Access Journals (Sweden)

    Sonia Vázquez-Díaz

    2017-11-01

    Full Text Available La Casa Carvajal es el resultado de una profunda reflexión sobre el papel del patio en la arquitectura moderna; un arquetipo inicialmente repudiado al juzgarse asociado a una espacialidad tradicional, introvertida y deudora de una concepción escindida entre interior y exterior. Sin embargo, tras este primer rechazo, el patio se incorpora de forma paulatina a la modernidad y, gracias precisamente a la integración de la concavidad que proporciona, permite que evolucionen y se complejicen los conceptos espaciales de la misma, tanto en relación a la apertura y fenomenización del espacio, como a la transparencia fenomenológica. Este artículo se propone mostrar cómo estos conceptos se manifiestan en los patios interiorizados de la Casa Carvajal, revelando, gracias a ello, la función determinante de los patios en la culminación de la modernidad. Mediante el análisis del orden formal y de las percepciones, a lo largo de la secuencia espacial que va desde el acceso hasta el entorno de los patios, se pondrá además de manifiesto que estos vacíos constituyen elementos esenciales en la estrategia de proyecto, tanto en el plano morfo-sintáctico, al constituir el germen de la lógica formal, como en el plano perceptivo-emocional, al cualificar el espacio como marco del habitar.

  5. Estudios previos para la restauración de la azotea de la Casa Milá de Barcelona (Cataluña, España

    Directory of Open Access Journals (Sweden)

    Lacuesta Contreras, Raquel

    1993-12-01

    Full Text Available The Casa Milá of Barcelona, work of the architect Antoni Gaudí, built between 1906 and 1911, was purchased in by the Caixa de Catalunya which then started a process of restoration of the building. One of the stages of this intervention will consist of restoring the roof with all the architectural sculptural elements it contains (the staircase boxes, chimneys, ventilation towers and perimetral paths. A number of previous studies have been done to this end. They deal with the historical constructive, documentary and artistic aspects of all these elements as well as with an action proposal to be taken into account in the restoration project.

    La Casa Milá de Barcelona, obra del arquitecto Antoni Gaudí construida entre 1906 y 1911, fue adquirida en 1986 por la Caixa de Catalunya que a partir de entonces inició un proceso de restauración del edificio. Una de las fases de la intervención consistirá en restaurar la azotea con todos los elementos arquitectónicos-escultóricos que contiene (cajas de escalera, chimeneas, torres de ventilación y pasos de ronda. A tal fin, se han realizado unos estudios previos que contemplan los aspectos histórico-constructivos, documental y artístico de todos estos elementos, y también una propuesta de actuación a tener en cuenta en el proyecto de restauración.

  6. Reflexión histórica sobre el P. Las Casas en la obra de Miguel Ángel Asturias

    Directory of Open Access Journals (Sweden)

    Hidefuji Someda

    2013-08-01

    Full Text Available Se descubre y analiza el perfil histórico y político de Bartolomé de Las Casas, según la configuración literaria que elabora Miguel Ángel Asturias en su obra teatral La audiencia de los confines. Mediante un cotejo de datos históricos, se examina la interpretación que ofrece el escritor guatemalteco del clérigo sevillano, en cuanto a su papel de reivindicador de los derechos de los indios, y de denunciador de los crímenes de parte de los conquistadores españoles. The historical and political profile of Bartolomé de Las Casas is discovered and analyzed, according to the literary configuration of Miguel Ángel Asturias in his play La audiencia de los confines. By verifying historical data, a description is provided of the interpretation of that Guatemalan author of the Sevillian priest, regarding his role in defending the rights of the indigenous peoples and in denouncing the crimes of the Spanish conquerors.

  7. A Casa da Cerca, um projeto de autor: 20 anos de programação para o diálogo

    Directory of Open Access Journals (Sweden)

    Emília Ferreira

    2014-06-01

    Full Text Available Aberta ao público em 1993, a Casa da Cerca-Centro de Arte Contemporânea, equipamento cultural da Câmara Municipal de Almada instalado numa antiga quinta de recreio setecentista, foi um projeto da autoria do pintor Rogério Ribeiro, a convite da autarquia. O programa inicial de investigação e divulgação da história e da contemporaneidade do exercício do desenho, mantém-se até hoje. Amado por uns, criticado por outros e constantemente debatido no seio da instituição, ele vai sendo repensado por uma equipa que, mantendo o eixo do projeto inicial, o tem atualizado e, no processo, criado com os visitantes uma relação privilegiada, que tem aumentado e fidelizado os diversos públicos. Este artigo pretende oferecer o testemunho de um projeto com participação biográfica — e que até agora foi tema de duas dissertações de mestrado em museologia e turismo — e evocar algumas das estratégias da Casa da Cerca no relacionamento com a sua envolvente e os seus públicos, através da sua programação, num momento em que celebra 20 anos de atividade cultural.

  8. Fluorescent multiple staining and CASA system to assess boar sperm viability and membranes integrity in short and long-term extenders.

    Science.gov (United States)

    Lange-Consiglio, A; Meucci, A; Cremonesi, F

    2013-01-01

    The aim of this study was to assess the effect on boar spermatozoa quality of in vitro storage in short and long-term extenders by fluorescent multiple staining (FMS) and computer assisted semen analyzer (CASA). Fresh ejaculates from three healthy, sexually mature boars were diluted with equal volumes of six short-term or three long-term commercial extenders and stored at 19°C for 6 days (short-term) or 12 days (long-term). The integrity of spermatozoa membranes was analyzed by FMS using propidium iodide, 5,5',6,6'-tetrachloro-1,1',3,3' tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) and fluorescein isothiocyanate-conjugated peanut agglutinin (PNA). The results obtained from this staining were compared with spermatozoa motility assessed by CASA. Our study showed that the number of viable spermatozoa with non-reacted acrosomes and intact mitochondria was positively correlated with the rate of motile spermatozoa (r(2)>0.9) irrespective of the extender used. In all extenders the number of motile spermatozoa significantly decreased as preservation period increased (P<0.05). FMS test is a potent indicator of sperm motility because it analyses mitochondrial integrity independently from observable alterations in motility. The best performing extenders were BTS for short-term storage and TRI-x-Cell for long-term storage.

  9. Quando as lembranças doem: a casa da infância em Vermelho amargo, de Bartolomeu Campos de Queirós

    Directory of Open Access Journals (Sweden)

    Marcela Verônica da Silva

    2016-01-01

    Full Text Available La última obra de Bartolomeu Campos de Queirós, la novela Vermelho Amargo (2011 es notable por su forma y contenido. La portada de la primera edición hecha por Cosac Naify, de color rojo oscuro y sin la vida que caracteriza a los tonos púrpura, anuncia el contenido doloroso de la narración, que es una mezcla de memorias en prosa poética y de escritura autobiográfica. Las imágenes de la infancia se abren como heridas mal curadas, y el lector tiene la oportunidad de desvelar el poder del verbo poético cuando se enfrenta directamente a estas llagas. En el presente artículo nos proponemos analizar la escritura autobiográfica y la memoria narrativa, con el fin de poner de relieve la imagen de la casa como construcción de la conciencia. Estos temas tienen el apoyo teórico de Gaston Bachelard especialmente en sus reflexiones sobre la poética del espacio relacionada con la primera casa, considerado lugar de formación de las subjetividades del ser.

  10. La satisfacción de residentes con su colonia y el programa gubernamental Tu Casa en el estado de Zacatecas

    Directory of Open Access Journals (Sweden)

    Jorge Ibarra Salazar

    2016-01-01

    Full Text Available El grado de satisfacción residencial, considerado como un indicador de nivel de vida, tiene como uno de sus componentes la satisfacción con la colonia de los individuos. En este artículo estimamos una serie de modelos para analizar el grado de satisfacción con la colonia de una muestra de hogares en el estado de Zacatecas. Las estimaciones nos permiten determinar si el programa federal de vivienda Tu Casa en ese estado, operado de 2004 a 2009, tuvo alguna influencia en el grado de satisfacción con la colonia, de acuerdo con la percepción de los residentes entrevistados. Encontramos evidencia de que el referido programa causó un efecto significativo en el grado de satisfacción del grupo de familias beneficiarias. Además de ese resultado, la estimación por mínimos cuadrados ordinarios muestra que el acceso vial, la contaminación ambiental, la percepción del valor de la casa y el tiempo de vivir en la vivienda influyen de forma significativa en el grado de satisfacción con la colonia. En los modelos estimados por probit y logit encontramos evidencia de que la seguridad pública y la posesión del inmueble también influyen en tal satisfacción.

  11. Fluorescent multiple staining and CASA system to assess boar sperm viability and membranes integrity in short and long-term extenders

    Directory of Open Access Journals (Sweden)

    F. Cremonesi

    2013-03-01

    Full Text Available The aim of this study was to assess the effect on boar spermatozoa quality of in vitro storage in short and long-term extenders by fluorescent multiple staining (FMS and computer assisted semen analyzer (CASA. Fresh ejaculates from three healthy, sexually mature boars were diluted with equal volumes of six short-term or three long-term commercial extenders and stored at 19°C for 6 days (short-term or 12 days (long-term. The integrity of spermatozoa membranes was analyzed by FMS using propidium iodide, 5,5’,6,6’-tetrachloro-1,1’,3,3’ tetraethylbenzimidazolyl-carbocyanine iodide (JC-1 and fluorescein isothiocyanate-conjugated peanut agglutinin (PNA. The results obtained from this staining were compared with spermatozoa motility assessed by CASA. Our study showed that the number of viable spermatozoa with non-reacted acrosomes and intact mitochondria was positively correlated with the rate of motile spermatozoa (r2>0.9 irrespective of the extender used. In all extenders the number of motile spermatozoa significantly decreased as preservation period increased (P<0.05. FMS test is a potent indicator of sperm motility because it analyses mitochondrial integrity independently from observable alterations in motility. The best performing extenders were BTS for short-term storage and TRI-x-Cell for long-term storage.

  12. A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

    Science.gov (United States)

    McKeegan, K. D.; Liu, M.-C.

    2015-07-01

    Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

  13. Efeito do Solo do Materias Organicos E do Adubo Formula 4N:14P:8K Para Producao DA Batata (Solanum tuberosum L.) Semente Pre-Basica no Casa de Vegetacao

    Science.gov (United States)

    László, Márton

    2010-05-01

    Widely well know that the potato is an important vegetable crop at Brazíl. Plant grown on about 173.000 ha, with total yield of 2.6 million tons year-1. The average yield is about 15 t ha-1. This level is very low because degeneration of crop is rapid under high temperature and high viruses pressure. Therefore seed potato propagation and production is principal on consumption potato production. This is why we found it necessary to develop it. The latossolo vermelho soil-farmyard manure- burnt rice straw-fertilizer 4N:14P:8K greenhouse pot trial was set up at the National Vegetable Crops Research Center, Brasília-DF, Brazíl in 1990. The methods of the experiments were soil x farmyard manure x burnt rice straw, soil x 4N:14P:8K fertilizer and soil x farmyard manure x burnt rice straw x 4N:14P:8K fertilizer on randomized block design in total 29 combination of treatments in 5, 5 and 3 repetitions with in a total parcel of 116. According to chemical analysis of the a., soil, b., farmyard manure and c., burnt rice straw the agrochemistry parameters were as follows: a., latossolo vermelho soil: CaCO3 0.3-0.7%, humo 0.9-1.0%, pH (H2O) 5.3, pH (KCl) 4.5, AL- P2O5 3.2-3.5 mg kg-1, AL- K2O 180 mg kg-1, Mg (KCl) 70 mg kg-1, EDTA-Zn 0.5-0.8 mg kg-1, EDTA-Cu 0.5-0.6 mg kg-1, b., farmyard manure: N 1.8 g kg-1, P2O5 2.0 g kg-1, K2O 4.0 g kg-1, c., burnt rice straw: N 0.8 g kg-1, P2O5 7.0 g kg-1, K2O 4.5 g kg-1. The experimental datas were estimated by analysis of variance, ANOVA and MANOVA. The main conclusions were as follows: 1. Mixture of 80% latossolo vermelho, 10% burnt rice straw and 10% farmyard manure were shown best performance on seed potato productivity. The piece of tubers with a 0-20 mm (consumption seeds) was increased by 77%. 2. Total seed potato number was reached maximum at 10.8 g pot-1 4N:14P:8K fertilizer regarding to average of treatments with a 33%. 3. Dry biomassa production plant-1 was decreased by high dose of 4N:14P:8K fertilizer (18.0 g pot-1) with a

  14. Reference evapotranspiration estimation inside greenhouses Evapotranspiração de referência estimativa em casas de vegetação

    Directory of Open Access Journals (Sweden)

    Carolina Fernandes

    2003-01-01

    Full Text Available Because of the large area occupied by a class A pan, alternative methods have been sought to estimate reference evapotranspiration (Eto inside greenhouses. The objective of this work was to compare ETo estimated by different methods inside and outside a greenhouse. A class A pan (CAPi, a reduced pan (RPi and an atmometer (Ai were installed inside a greenhouse, and another class A pan (CAPo was installed outside. ETo estimates, obtained by CAPi, RPi, and Ai were 56%, 69% and 63% of those estimated by CAPo, respectively. A simple linear regression showed positive coefficients R = 0.94 for the RPi and the CAPi, R = 0.91 for the Ai and the CAPi, R = 0.70 for the CAPi and the CAPo, R = 0.66 for the RPi and the CAPo, and R = 0.62 for the Ai and the CAPo. ETo needs to be estimated inside greenhouses and it is possible to use reduced pans or atmometers to estimate the ETo inside the greenhouse. Equipment replacement would increase the available space inside the greenhouse.Em função da área ocupada pelo tanque classe A, tem-se procurado utilizar métodos alternativos para a estimativa da evapotranspiração de referência (ETo dentro de casas de vegetação. O trabalho teve como objetivo comparar a ETo estimada pelo método do tanque classe A instalado dentro (TCAd e fora (TCAf da casa de vegetação e pelos métodos do tanque reduzido (TRED e do atmômetro (ATM instalados dentro da casa de vegetação. Os valores estimados da ETo foram comparados por análises de regressão linear simples. ETo estimada pelo TCAd, TRED e ATM correspondeu a 56%, 69% e 63% da ETo estimada pelo TCAf, respectivamente. As regressões entre os valores das ETo estimados pelo TCAd e pelos outros dois métodos apresentaram valores do coeficiente de correlação (R de 0,94 para o método do TRED e de 0,91 para o método do ATM. As regressões entre os valores das ETo estimados pelo TCAf e aqueles estimados dentro da mesma pelos diferentes métodos, apresentaram valor de R de 0

  15. Effect of a Collaborative Care Intervention vs Usual Care on Health Status of Patients With Chronic Heart Failure: The CASA Randomized Clinical Trial.

    Science.gov (United States)

    Bekelman, David B; Allen, Larry A; McBryde, Connor F; Hattler, Brack; Fairclough, Diane L; Havranek, Edward P; Turvey, Carolyn; Meek, Paula M

    2018-04-01

    Many patients with chronic heart failure experience reduced health status despite receiving conventional therapy. To determine whether a symptom and psychosocial collaborative care intervention improves heart failure-specific health status, depression, and symptom burden in patients with heart failure. A single-blind, 2-arm, multisite randomized clinical trial was conducted at Veterans Affairs, academic, and safety-net health systems in Colorado among outpatients with symptomatic heart failure and reduced health status recruited between August 2012 and April 2015. Data from all participants were included regardless of level of participation, using an intent-to-treat approach. Patients were randomized 1:1 to receive the Collaborative Care to Alleviate Symptoms and Adjust to Illness (CASA) intervention or usual care. The CASA intervention included collaborative symptom care provided by a nurse and psychosocial care provided by a social worker, both of whom worked with the patients' primary care clinicians and were supervised by a study primary care clinician, cardiologist, and palliative care physician. The primary outcome was patient-reported heart failure-specific health status, measured by difference in change scores on the Kansas City Cardiomyopathy Questionnaire (range, 0-100) at 6 months. Secondary outcomes included depression (measured by the 9-item Patient Health Questionnaire), anxiety (measured by the 7-item Generalized Anxiety Disorder Questionnaire), overall symptom distress (measured by the General Symptom Distress Scale), specific symptoms (pain, fatigue, and shortness of breath), number of hospitalizations, and mortality. Of 314 patients randomized (157 to intervention arm and 157 to control arm), there were 67 women and 247 men, mean (SD) age was 65.5 (11.4) years, and 178 (56.7%) had reduced ejection fraction. At 6 months, the mean Kansas City Cardiomyopathy Questionnaire score improved 5.5 points in the intervention arm and 2.9 points in the control

  16. Lattice Dynamics of fcc Ca

    DEFF Research Database (Denmark)

    Stassis, C.; Zaretsky, J.; Misemer, D. K.;

    1983-01-01

    A large single crystal of FCC Ca was grown and was used to study the lattice dynamics of this divalent metal by coherent inelastic neutron scattering. The phonon dispersion curves were measured, at room temperature, along the [ξ00], [ξξ0], [ξξξ], and [0ξ1] symmetry directions. The dispersion curves...... to the propagation of elastic waves. The frequencies of the T1[ξξ0] branch for ξ between approximately 0.5 and 0.8 are slightly above the velocity-of-sound line determined from the low-frequency measurements. Since a similar effect has been observed in FCC Yb, it is natural to assume that the anomalous dispersion...... bear a striking resemblance to those of FCC Yb, which is also a divalent metal with an electronic band structure similar to that of Ca. In particular, the shear moduli c44 and (c11-c 12)/2 differ by a factor of 3.4, which implies that FCC Ca (like FCC Yb) is very anisotropic with regard...

  17. Tendências e perspectivas da administração em enfermagem: Um estudo na Santa Casa de Belo Horizonte-MG Tendencias y perspectivas de la administración en enfermería un estudio en la Santa Casa de Belo Horizonte-MG Trends and perspectives of nursing administration: a study in the "Santa Casa" Hospital of Belo Horizonte-MG, Brazil

    Directory of Open Access Journals (Sweden)

    Carla Aparecida Spagnol

    2002-01-01

    Full Text Available A Santa Casa de Belo Horizonte implantou um novo Sistema de Gestão que a caracterizou como uma organização flexível. Partindo desse contexto, delineamos como objetivos deste estudo: analisar a forma da administração em enfermagem, considerando a implantação do SIGESC; descrever como a equipe de enfermagem percebe a comunicação, o processo decisório e as relações interpessoais; identificar possíveis tendências e perspectivas presentes na prática administrativa desenvolvida. Evidenciamos um momento de transição da administração em enfermagem que apresenta traços da gerência clássica e da gerência contemporânea. Entretanto, sinalizamos tendências e perspectivas que poderão contribuir para a reorganização do processo de trabalho da enfermagem na área hospitalar.La Santa Casa de Belo Horizonte, implantó un nuevo Sistema de Gestión, caracterizándose como una organización flexible. Partiendo de este contexto, delimitamos como objetivos: analizar la forma de administración en enfermería, considerando la implementación del SIGESC; describir como el equipo de enfermería percibe la comunicación, el proceso de toma de decisiones y las relaciones interpersonales; identificar posibles tendencias y perspectivas presentes en la práctica administrativa desarrollada. Evidenciamos un momento de transición de la administración en enfermería que presenta trazos de la gerencia clásica y de la gerencia contemporánea. Por ahora, señalamos tendencias y perspectivas que podrán contribuir para la reorganización del proceso de trabajo de enfermería en el área hospitalaria.The "Santa Casa" Hospital of Belo Horizonte has implemented a new management system that has characterized it as a flexible organization. Based on this context, the authors of this research defined the following objectives: to analyze nursing administration by considering the implementation of the Management System (SIGESC, to describe how the nursing team

  18. Quality, height, age and home advantage in boxing. [Calidad, altura, edad y la ventaja de boxear en casa].

    Directory of Open Access Journals (Sweden)

    Miguel Pic

    2018-04-01

    Full Text Available Abstract The main objective of the present study was the identification of performance indicators in boxing and their impact on the concept of home advantage (HA, among other variables. Professional boxing bouts of the European ranking were selected (N = 522, to generate 1044 units of analysis. ANOVA and T-student analyzes were applied to determine the influence of the difference between boxers in: a quality, calculated by the number of combats won, opponent's quality, inactivity time, among other indicators; b height and c age, depending on the result obtained and the location of the combat. It was also used as an influential variable in the final result. By multivariate analysis (CHAID model, the quality difference between boxers was the most determinant variable (p <.000 to reach the final result, but it was also predictive regarding the combat location (p <.006. The study allowed for revealing determinant effects for the performance in boxing through the crossing of variables and analysis techniques. Suggesting coaches and boxing practitioners to do a thorough review of their training tasks based on the location of their commitments and the boxers’ characteristics means they would profit the specificity of each match. The calculation of the risk percentage assumed by professional boxers to achieve success in professional boxing, is one of the practical applications of this research. Resumen El objetivo principal del presente estudio fue la identificación de indicadores de rendimiento en boxeo y su incidencia sobre el concepto de ventaja de jugar en casa (HA, entre otras variables. Fueron seleccionados combates profesionales del ranking Europeo (N=522 dando lugar a 1044 unidades de análisis. Fueron aplicados análisis ANOVA y T-student para determinar la influencia de la diferencia entre boxeadores en: a calidad, calculada mediante el número de combates ganados, calidad del oponente, tiempo de inactividad, entre otros indicadores; b

  19. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

    Science.gov (United States)

    Kim, Eun Young; Rumpf, Christine H; Van Petegem, Filip; Arant, Ryan J; Findeisen, Felix; Cooley, Elizabeth S; Isacoff, Ehud Y; Minor, Daniel L

    2010-12-01

    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ helices bridged by two Ca(2+)/CaMs and two Ca(2+)/CaM-IQ domain complexes. Sedimentation equilibrium experiments establish that the complex has a 2:1 Ca(2+)/CaM:C-terminal tail stoichiometry and does not form higher order assemblies. Moreover, subunit-counting experiments demonstrate that in live cell membranes Ca(V)1.2s are monomers. Thus, contrary to previous proposals, the crystallographic dimer lacks physiological relevance. Isothermal titration calorimetry and biochemical experiments show that the two Ca(2+)/CaMs in the complex have different properties. Ca(2+)/CaM bound to the PreIQ C-region is labile, whereas Ca(2+)/CaM bound to the IQ domain is not. Furthermore, neither of lobes of apo-CaM interacts strongly with the PreIQ domain. Electrophysiological studies indicate that the PreIQ C-region has a role in calcium-dependent facilitation. Together, the data show that two Ca(2+)/CaMs can bind the Ca(V)1.2 tail simultaneously and indicate a functional role for Ca(2+)/CaM at the C-region site.

  20. Respuesta a: Comentarios sobre “Puntos de equilibrio asintóticamente estables en nuevos sistemas caóticos”

    Directory of Open Access Journals (Sweden)

    K. Casas-García

    2017-01-01

    Full Text Available Debido a que el Teorema 1 de (Elhadj and Sprott, 2012 es erróneo, algunos de los sistemas encontrados en el artículo (Casas - García et al . 2016 pueden tener orbitas homoclínicas o heteroclínicas pudiendo aparecer caos en el sentido de Shilnikov. Sin embargo, la aportación fundamental de nuestro artículo fue encontrar diez sistemas dinámicos simples, en tres dimensiones, con términos no lineales cuadráticos, que presentan un punto de equilibrio asintóticamente estable y son caóticos, lo cual se logró. Estos se obtuvieron usando el método Monte Car lo aplicado específicamente para la búsqueda de estos sistemas.