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Sample records for yi yao wei

  1. A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

    Directory of Open Access Journals (Sweden)

    Shu-Chen Chien

    2014-01-01

    Full Text Available Jia-wei-xiao-yao-san (JWXYS is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN- induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT and serum glutamic pyruvic transaminase (SGPT levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.

  2. Yi Tan

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Yi Tan. Articles written in Bulletin of Materials Science. Volume 38 Issue 5 September 2015 pp 1429-1433. Evaluation on electrical resistivity of silicon materials after electron beam melting · Hafiz Muhammad Noor Ul Huda Khan Asghar Shuang Shi Dachuan Jiang Yi Tan.

  3. Yi lin cuo yao(Essentials of Medical Works) and its historical materials of medical exchanges between China and Korea%朝鲜《医林撮要》所载中朝医学交流史料研究

    Institute of Scientific and Technical Information of China (English)

    梁永宣

    2001-01-01

    由朝鲜内医郑正先撰、杨礼寿校正,成书于16~17世纪时期的《医林撮要》一书,共13卷128门,它引用了大量李朝前期的朝鲜医书及当时已成书的中国医书资料,是一部非常切合临床应用的综合性方书。特别是书中所收载的“中朝质问方”和“中朝传习方”中的方剂,若干处与中国宋代医书《仁斋直指方论》等有诸多联系,是中国和朝鲜医学交流过程中的重要记录。但它与记载中朝两国政府官员之间医学质问的傅懋光《医学疑问》毫不相关。%Yi lin cuo yao,including 13 chapters and 128 categories,was written by Zheng Zhengxian and collated by Yang Lishou,both Korean imperial physicians in the 16-17th centuries.With notation of a number of the Chinese and Korean medical books and materials in the first decade of the Li dynasty,this book is a comprehensive prescription work,very useful to clinical application.Especially with several points of the formulas from Zhong chao zhi wen fang (Sino-Korean Prescriptions of Questioning) and zhong chao chuan xi fang (Sino-Korean Prescriptions of Questioning) recorded in this book connected with Ren zhai zhi zhi fang lun (Renzhai's Comprehensive Prescriptions) in the Song dynasty.This book is an important record of the exchanges on medical ideas between China and Korea.However,it has nothing to do with Yi xue yi wen (Questions on Medicine) by Fu Maoguang,which records the questions and answers between Chinese and Korean officials.

  4. Hui Wei | NREL

    Science.gov (United States)

    Hui Wei Photo of Hui Wei Hui Wei Researcher IV-Molecular Biology Hui.Wei@nrel.gov | 303-384-6620 consortia system. Additional Publications "In Situ Micro-Spectroscopic Investigation of Lignin in Molecular Biology (2012) "Tracking Dynamics of Biomass Composting by Monitoring the Changes in

  5. YI LING QI

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. YI LING QI. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1329-1333. Synthesis and enhanced photocatalytic activity of g-C 3 N 4 hybridized CdS nanoparticles · QING YING LIU YI LING QI YI FAN ZHENG XU CHUN SONG · More Details ...

  6. yi fan zheng

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. YI FAN ZHENG. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1329-1333. Synthesis and enhanced photocatalytic activity of g-C 3 N 4 hybridized CdS nanoparticles · QING YING LIU YI LING QI YI FAN ZHENG XU CHUN SONG.

  7. Genetics Home Reference: Yao syndrome

    Science.gov (United States)

    ... on PubMed Yao Q, Myles J, Shen B, McDonald C. NOD2-associated autoinflammatory disease: an exploratory study ... 28. Citation on PubMed Yao Q, Shen M, McDonald C, Lacbawan F, Moran R, Shen B. NOD2- ...

  8. Typhoon Man-Yi

    Science.gov (United States)

    2007-01-01

    Typhoon Man-Yi was pummeling the Japanese island of Okinawa with winds between 230 and 295 kilometers per hour (125-160 knots, 144-184 miles per hour) and heavy rain on the morning of July 13, 2007, when the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Terra satellite captured this image. The immense storm covered hundreds of kilometers with spiraling bands of thunderstorms, though it had lost the distinctive cloud-free eye it exhibited the day before. Typhoons are common in Japan, but powerful typhoons usually strike the island nation later in the year. The Japan Meteorological Agency said that Man-Yi is the fourth typhoon of the 2007 season and may be the most powerful ever observed in the northwest Pacific in July, reported Kyodo News. The Joint Typhoon Warning Center expected the typhoon to strike Kyushu, a southern Japanese island, on July 14, and then curve northeast along the eastern shore of Japan. By the time the storm reaches Tokyo on July 15, it should be degraded to a tropical storm. As of July 13, Typhoon Man-Yi had injured eight and flooded twenty houses in Okinawa, and forced airlines to cancel hundreds of flights, said Kyodo News. The storm was expected to bring heavy rain to Japan's Pacific coast. NASA image created by Jesse Allen, using data provided courtesy of the MODIS Rapid Response team.

  9. Editorial: Which Wei Wang?

    International Nuclear Information System (INIS)

    Sprouse, Gene D.

    2007-01-01

    The APS journals receive manuscripts from scientists all over the world. For authors whose names cannot be expressed in Latin characters, their names in the byline must be transliterated, a process that is not necessarily bidirectionally unique. For example, the eight Chinese names all transliterate as Wei Wang. To remove some of the ambiguity arising from this unfortunate degeneracy of names, APS will allow some authors the option to include their names in their own language in parentheses after the transliterated name, such as Wei Wang. The option to present names in the article byline in this manner is an experiment initially offered to Chinese, Japanese, and Korean authors, whose names can be expressed in Unicode characters. An example of a Japanese name is Tadanori Minamisono and a Korean name is Chang Kee Jung. In the English text the given name precedes the family name, while the reverse is true for the characters. As we gain experience, we may be able to broaden this offer to other languages. Authors who wish to try this option will need to prepare their manuscripts by following the special instructions at http://authors.aps.org/names.html

  10. The Educational Process of Yao Nationality

    Institute of Scientific and Technical Information of China (English)

    邓桦

    2014-01-01

    As an important theory and practical problem,“educational process”draws double concerns both from educational the-ory and practice. Yao nationality of China is a constantly migratory minority group without its own words, However ,relying on its own unique educational process,this minority maintain its own distinctive national characteristics and keep a strong ethical identity.

  11. Effects of Traditional Chinese Medicine Wei-Wei-Kang-Granule on ...

    African Journals Online (AJOL)

    Wei-Wei-Kang-Granule(WWKG) is a traditional Chinese medicine (TCM) preparation for the treatment of chronic atrophic gastritis (CAG). We examined the pathologic change and the effects of Wei-Wei-Kang-Granule (WWKG) on the expression of EGFR (epiderminal growth factor receptors) and NF-kB (nuclear transcription ...

  12. Natural radioactivity of sediments from Wei River of Shannxi province

    International Nuclear Information System (INIS)

    Wang Fengling; Lu Xinwei

    2008-01-01

    The natural radioactivity level in sediments from Wei River of Shannxi has been surveyed with a NaI(Tl) γ-spectrometer and its radiation hazards to the people has been assessed. The results indicate the natural radioactivity level in sediments from Wei River of Shaanxi is normal and the sediments can be safely used as building materials. (authors)

  13. 姚兰的穷爸爸%Yao Lan's Poor Father

    Institute of Scientific and Technical Information of China (English)

    Jack

    2004-01-01

    @@ When Yao Lan was born, her parents were both working in a factory that produced newsprint paper. The paper from the factory was considered good quality and all the workers enjoyed a fairly prosperous( 富裕的 ) lifestyle, not that they were rich. They were really only comfortable, but much more than most of their counterparts(对应的人) in other factories. So, when Yao Lan came along, Yao Long, her father and An Ying, her mother were both very happy. Yao Lan's father and mother each earned three hundred yuan and in the early eighties that amount went a long way. They knew they could take good care of their daughter and provide her a decent upbringing(抚育).

  14. Approximate solutions of the Wei Hua oscillator using the Pekeris ...

    Indian Academy of Sciences (India)

    The approximate analytical bound-state solutions of the Schrödinger equation for the. Wei Hua oscillator are carried out in N-dimensional space by taking Pekeris approximation scheme to the orbital centrifugal term. Solutions of the corresponding hyper-radial equation are obtained using the conventional Nikiforov–Uvarov ...

  15. Yao et al., Afr J Tradit Complement Altern Med. (2014) 11(1):222-227

    African Journals Online (AJOL)

    cadewumi

    . HIGH-FAT-DIET-INDUCING NON-ALCOHOLIC STEATOHEPATITIS IN RATS. Zheng Yao1, Xiao-Chen Liu 2, Ying-Er Gu 3*. 1Zhejiang Cancer Hospital, Hangzhou, [310022], P.R. China. 2Affiliated Hospital of Stomatology, School of Medicine ...

  16. Feng xian tai du yu jiao yu he zhi ye xuan ze xing wei: yi ge shi yan fang fa de yan jiu an li

    NARCIS (Netherlands)

    Ding, X.; Sun, Y.; Hartog, J.

    2009-01-01

    An experimental study on risk attitude and choice behavior of education and career This paper introduces a research on risk attitude and choice behavior of education and career. Using the experimental methods, this study focuses on testing the reliability and validity of risk attitude measurement.

  17. Weiße und Braune Zwerge zeigen sich unwirtlich

    Science.gov (United States)

    Heller, René

    2013-02-01

    Mehr als 850 Exoplaneten haben Astronomen seit dem Jahr 1992 nachgewiesen. Die meisten von ihnen umkreisen normale Hauptreihensterne, aber es wurden auch Trabanten im Umlauf um Braune oder Weiße Zwerge aufgespürt. Nun haben Rory Barnes von der University of Washington in Seattle und René Heller am Leibniz-Institut für Astrophysik Potsdam die Bewohnbarkeit möglicher Planeten um solche Objekte untersucht und dabei festgestellt, dass sie für Leben, wie wir es kennen, ungeeignet sind.

  18. MICB gene diversity and balancing selection on its promoter region in Yao population in southern China.

    Science.gov (United States)

    Chen, Xiang; Liu, Xuexiang; Wei, Xiaomou; Meng, Yuming; Liu, Limin; Qin, Shini; Liu, Yanyu; Dai, Shengming

    2016-12-01

    To comprehensively examine the MICB gene polymorphism and identify its differences in Chinese Yao population from other ethnic groups, we investigated the polymorphism in the 5'-upstream regulation region (5'-URR), coding region (exons 2-4), and the 3'-untranslated region (3'-UTR) of MICB gene by using PCR-SBT method in 125 healthy unrelated Yao individuals in Guangxi Zhuang Autonomous Region. Higher polymorphism was observed in the 5'-URR, nine single nucleotide polymorphisms (SNPs) and a two base pairs deletion at position -139/-138 were found in our study. Only five different variation sites, however, were detected in exons 2-4 and three were observed in the 3'-UTR. The minor allele frequencies of all variants were greater than 5%, except for rs3828916, rs3131639, rs45627734, rs113620316, rs779737471, and the variation at position +11803 in the 3'-UTR. The first nine SNPs of 5'-URR and rs1065075, rs1051788 of the coding region showed significant linkage disequilibrium with each other. Ten different MICB extended haplotypes (EH) encompassing the 5'-URR, exons 2-4, and 3'-UTR were found in this population, and the most frequent was EH1 (23.2%). We provided several evidences for balancing selection effect on the 5'-URR of MICB gene in Yao population. Copyright © 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

  19. The Impact and Role of the Yi Civil Corps on Ethnic Work in Liangshan

    Institute of Scientific and Technical Information of China (English)

    MA Linying

    2013-01-01

    The formation and growth of Yi Civil Corps of the CPLA ( Chinese People ’ s Lib-eration Army ) Chengdu military region began and developed with the establishment of the Liangshan Yi Autonomous Prefecture .From the beginning to the end of its 34 year mission of military develop-ment the Yi Civil Corps made an irreplaceable con-tribution to the liberation of the people and the e-conomic development in Liangshan .However , due to various reasons , this unique historical episode which linked the military and civil people only re-mains in folk memory and was recorded only in some unpublished internal materials .So, the ma-jority of the public does not know about it .Based upon references taken from publications by Liang Wenying , Mao Junru , Li Shian and the Chinese Academy of Sciences , this article , for the first time, discusses the special military history of the CPLA by taking Yi Civil Corps as an example . After the CPLA liberated Liangshan in March , 1950 , in order to maintain local social or-der, speed up production and construction , and cultivate ethnic cadres , Liao Zhigao , the Party secretary of Sichuan province of the time , together with the Party Committee in Tibetan and Yi re-gions, established the Yi and Tibetan Civil Corps of the CPLA in November 1952.They did this by taking into account the reality and characteristics of ethnic works in the Tibetan and Yi regions , and af-ter reporting to the central military commission for approval .The establishment of Yi Civil Corps adds a new historical page for the glorious history of the Yi people .Just like the establishment of all levels of governments of the Yi people , it marks a new beginning in the lives of the Yi people .It declared a revival for the Yi people who had experienced great vicissitudes , the separation of their family clans, constant internal warfare , and who were generally in a poor and backward situation .The establishment of the Yi Civil Corps not only em-bodied the Chinese Communist

  20. Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

    Directory of Open Access Journals (Sweden)

    Chen JR

    2015-06-01

    Full Text Available Jing Rui Chen,1–3 Jing Wei,1–3 Ling Yan Wang,1–3 Yan Zhu,1–3 Lan Li,1–3 Mary Akinyi Olunga,1–3 Xiu Mei Gao,1–3 Guan Wei Fan1–31Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, People’s Republic of China; 2Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, 3Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of ChinaAim: To investigate the potential cardioprotective effects of QiShenYiQi Pill® (QSYQ on myocardial ischemia/reperfusion (I/R injury through antioxidative stress and mitochondrial protection.Methods and results: Sprague Dawley rats were pretreated with QSYQ or saline for 7 days and subjected to ischemia (30 minutes occlusion of the left anterior descending coronary artery and reperfusion (120 minutes. Cardiac functions were evaluated by echocardiogram and hemodynamics. Myocardial mitochondria were obtained to evaluate changes in mitochondrial structure and function, immediately after 120 minutes reperfusion. Pretreatment with QSYQ protected against I/R-induced myocardial structural injury and improved cardiac hemodynamics, as demonstrated by normalized serum creatine kinase and suppressed oxidative stress. Moreover, the impaired myocardial mitochondrial structure and function decreased level of ATP (accompanied by reduction of ATP5D and increase in the expression of cytochrome C. Myocardial fiber rupture, interstitial edema, and infiltrated leukocytes were all significantly ameliorated by pretreatment with QSYQ.Conclusion: Pretreatment of QSYQ in Sprague Dawley rats improves ventricular function and energy metabolism and reduces oxidative stress via ameliorating multiple mitochondrial dysfunctions during I/R injury.Keywords: QSYQ, ischemia/reperfusion injury, energy metabolism, mitochondria

  1. His Excellency Professor Dr Che-Ho Wei, Chairman, National Science Council Executive Yuan, Republic of China

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Professor Dr. Che-Ho Wei signing the Guest Book with CERN Director-General, L. Maiani. Photo 02: Professor Dr. Che-Ho Wei. Photo 03::Professor Dr. Che-Ho Wei shaking hands with CERN Director-General, L. Maiani.

  2. Caractérisation hydrochimique de la nappe de Yao et ses environs ...

    African Journals Online (AJOL)

    physicochimiques ont été effectuées sur 21échantillons d'eau de pompes de villages autours de Yao et l'eau du lac Fitri. .... cancer (Lara Fabriz et al., 2004). ..... MAMA. 17°36'12''. 13°00'28''. 322,5. 24,01. 298,49. 16. MASKAO. 17°39'54''. 12°58'35''. 354,6. 22,4. 332,2. 17. N'Djamena Bilala. 17°18'92''. 13°06'19''. 345.

  3. [Study on the first translated obstetrics book Tai chan ju yao (Essentials in Obstetrics)].

    Science.gov (United States)

    Wu, M

    2018-01-28

    In 1893, Wan Tsun-mo translated and published Tai chan ju yao ( Essentials in Obstetrics ), the first monograph of western obstetrics in modern China, symbolizing the independence of obstetrics from such maternal and child books as Fu ying xin shuo and Fu ke jing yun tu shuo , which occupies an important position in the history of the development of modern Chinese obstetrics. The book introduced anatomy, physiology, pathology, embryology, diagnostics, surgery, pharmacology and other knowledge of obstetrics in a catechismal form, and had a detailed discussion of such advanced obstetrical technologies as antiseptic, anesthesia, forceps and cesarean section for the first time.Judging from the content and translation of Tai chan ju yao , this book has already possessed the basic knowledge system of modern obstetrics, though the translation appeared to be somewhat jerky and not elegant and the terminology needing to be further improved, it was not only used as an important medium for the introduction of obstetrical knowledge, but also of great clinical value.However, its influence was so weak that later researchers seldom mentioned this book.

  4. 77 FR 34339 - Yufeng Wei, a/k/a Annie Wei, 165 Beech Street, Belmont, MA 02378; Order Denying Export Privileges

    Science.gov (United States)

    2012-06-11

    ... Street, Belmont, MA 02378; Order Denying Export Privileges On January 28, 2011, in the U.S. District... of the Arms Export Control Act (22 U.S.C. 2778 (2000)) (``AECA''). Specifically, Wei was convicted of... electronic components designated on the U.S. Munitions List to China through Hong Kong between 2004 and 2007...

  5. Analysis of temporal and spatial trends of hydro-climatic variables in the Wei River Basin.

    Science.gov (United States)

    Zhao, Jing; Huang, Qiang; Chang, Jianxia; Liu, Dengfeng; Huang, Shengzhi; Shi, Xiaoyu

    2015-05-01

    The Wei River is the largest tributary of the Yellow River in China. The relationship between runoff and precipitation in the Wei River Basin has been changed due to the changing climate and increasingly intensified human activities. In this paper, we determine abrupt changes in hydro-climatic variables and identify the main driving factors for the changes in the Wei River Basin. The nature of the changes is analysed based on data collected at twenty-one weather stations and five hydrological stations in the period of 1960-2010. The sequential Mann-Kendall test analysis is used to capture temporal trends and abrupt changes in the five sub-catchments of the Wei River Basin. A non-parametric trend test at the basin scale for annual data shows a decreasing trend of precipitation and runoff over the past fifty-one years. The temperature exhibits an increase trend in the entire period. The potential evaporation was calculated based on the Penman-Monteith equation, presenting an increasing trend of evaporation since 1990. The stations with a significant decreasing trend in annual runoff mainly are located in the west of the Wei River primarily interfered by human activities. Regression analysis indicates that human activity was possibly the main cause of the decline of runoff after 1970. Copyright © 2015. Published by Elsevier Inc.

  6. Genetic polymorphisms of pharmacogenomic VIP variants in the Yi population from China.

    Science.gov (United States)

    Yan, Mengdan; Li, Dianzhen; Zhao, Guige; Li, Jing; Niu, Fanglin; Li, Bin; Chen, Peng; Jin, Tianbo

    2018-03-30

    Drug response and target therapeutic dosage are different among individuals. The variability is largely genetically determined. With the development of pharmacogenetics and pharmacogenomics, widespread research have provided us a wealth of information on drug-related genetic polymorphisms, and the very important pharmacogenetic (VIP) variants have been identified for the major populations around the world whereas less is known regarding minorities in China, including the Yi ethnic group. Our research aims to screen the potential genetic variants in Yi population on pharmacogenomics and provide a theoretical basis for future medication guidance. In the present study, 80 VIP variants (selected from the PharmGKB database) were genotyped in 100 unrelated and healthy Yi adults recruited for our research. Through statistical analysis, we made a comparison between the Yi and other 11 populations listed in the HapMap database for significant SNPs detection. Two specific SNPs were subsequently enrolled in an observation on global allele distribution with the frequencies downloaded from ALlele FREquency Database. Moreover, F-statistics (Fst), genetic structure and phylogenetic tree analyses were conducted for determination of genetic similarity between the 12 ethnic groups. Using the χ2 tests, rs1128503 (ABCB1), rs7294 (VKORC1), rs9934438 (VKORC1), rs1540339 (VDR) and rs689466 (PTGS2) were identified as the significantly different loci for further analysis. The global allele distribution revealed that the allele "A" of rs1540339 and rs9934438 were more frequent in Yi people, which was consistent with the most populations in East Asia. F-statistics (Fst), genetic structure and phylogenetic tree analyses demonstrated that the Yi and CHD shared a closest relationship on their genetic backgrounds. Additionally, Yi was considered similar to the Han people from Shaanxi province among the domestic ethnic populations in China. Our results demonstrated significant differences on

  7. Relativistic Treatment of Spinless Particles Subject to a Tietz-Wei Oscillator

    Institute of Scientific and Technical Information of China (English)

    孙国华; 董世海

    2012-01-01

    The bound state solutions of the relativistic Klein-Gordon equation with the Tietz-Wei diatomic molecular potential are presented for the s wave. It is shown that the solutions can be expressed by the generalized hypergeometric functions. The normalized wavefunctions are also derived.

  8. River habitat assessment for ecological restoration of Wei River Basin, China.

    Science.gov (United States)

    Yang, Tao; Wang, Shuo; Li, Xiaoping; Wu, Ting; Li, Li; Chen, Jia

    2018-04-11

    As an important composition component of river ecosystems, river habitats must undergo quality assessment to potentially provide scientific basis for river ecological restoration. Substrate composition, habitat complexity, bank erosion degree, river meandering degree, human activity intensity, vegetation buffer width, water quality, and water condition were determined as indicators for river habitat assessment. The comprehensive habitat quality index (CHQI) was established for the Wei River Basin. In addition, the indicator values were determined on the basis of a field investigation at 12 national hydrological stations distributed across the Wei, Jing, and Beiluo Rivers. The analytic hierarchy process was used to determine the indicator weights and thus distinguish the relative importance of the assessment indicator system. Results indicated that the average CHQIs for the Wei, Jing, and Beiluo Rivers were 0.417, 0.508, and 0.304, respectively. The river habitat quality for the three rivers was well. As for the whole river basin, the river habitat quality for 25% of the cross section was very well, the other 25% was well, and the 50% remaining was in critical state. The river habitat quality of the Jing River was better than that of the Wei and Beiluo Rivers.

  9. Strength-based Supervision: Frameworks, Current Practice, and Future Directions A Wu-wei Method.

    Science.gov (United States)

    Edwards, Jeffrey K.; Chen, Mei-Whei

    1999-01-01

    Discusses a method of counseling supervision similar to the wu-wei practice in Zen and Taoism. Suggests that this strength-based method and an understanding of isomorphy in supervisory relationships are the preferred practice for the supervision of family counselors. States that this model of supervision potentiates the person-of-the-counselor.…

  10. The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Xiangsheng Wang

    2018-01-01

    Full Text Available Aims. To study the effect of the Chinese herb Yi-qi-huo-xue on cardiomyopathy in diabetic rats. Methods. Rats were fed a high fat and high glucose diet and injected with 50 ml/kg streptozotocin (STZ to induce diabetic cardiomyopathy (DCM, followed by treatment with Yi-qi-huo-xue for 4 weeks. We measured the rats’ heart weight index, observed the myocardial morphology using hematoxylin eosin (HE staining, and determined the content of collagen types I and III in the myocardium using enzyme-linked immunosorbent assay (ELISA. We determined Bcl-2, Bax, and P53 protein expression by Western blot analysis and the cardiomyocyte apoptosis rate via a flow cytometry assay. Results. Compared with the rats in the control group, the diabetic rats gained weight and had increased blood sugar levels, an enhanced heart weight index, and increased myocardial pathophysiological damage. There was a decrease in their Bcl-2 expression, and their Bax and P53 expression increased. The Bcl-2/Bax ratio was enhanced, and there was an increase in the content of collagen types I and III in the myocardium. After treatment with Yi-qi-huo-xue, all levels listed above returned to normal. Conclusion. The Chinese herb Yi-qi-huo-xue degraded the myocardial interstitial collagen types I and III to protect the myocardium of the diabetic rats, thus delaying the role of myocardial fibrosis. Yi-qi-huo-xue could play an important role in protecting the myocardium of DCM rats by enhancing the expression of the Bcl-2 protein, inhibiting the expression of the Bax and P53 proteins, increasing the ratio of Bcl-2/Bax, and inhibiting the apoptosis of cardiomyocytes.

  11. [Decipherment and annotation of some terms in the remnant scrolls of Hui hui yao fang (Huihui Formularies)].

    Science.gov (United States)

    Huang, Y; Wang, J

    2017-05-28

    The etymology of the terms in Hui hui yao fang ( Huihui Formularies ) is complicated. Their origin might be Arabian, Persian, or Sanskrit, or even the northern dialects of Han language during the Yuan and Ming Dynasties. There are obvious mistakes or indefinite decipherments and interpretations of the terms in Song Xian's Investigated Annotations of Huihui Formularies . There are also missing annotations for those transliterated terms. To tackle such defects, 12 such terms are deciphered and annotated here.

  12. Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections.

    Science.gov (United States)

    Li, Anyuan; Xie, Yanying; Qi, Fanghua; Li, Jie; Wang, Peng; Xu, Shulan; Zhao, Lin

    2009-08-01

    Yi-Fu-Qing granule is a traditional Chinese medicine for the treatment of acute respiratory tract infections. The present study sought to investigate the anti-virus effects of Yi-Fu-Qing granule on acute respiratory infections with respiratory syncytial virus (RSV) and human adenoviruses type 3 (Ad3). The cytotoxicity of Yi-Fu-Qing granule was evaluated by the neutral red assay on HeLa cells. The antiviral effect of Yi-Fu-Qing granule was tested by observing the cytopathogenic effect (CPE) with a compound mixture of Isatis leaf as the positive control drug. The results indicated that the highest non-toxicity concentration of Yi-Fu-Qing granule on Hela cells was 1:100. The CPE reduction assay showed that Yi-Fu-Qing granule inhibited RSV and Ad3 replication at a concentration of 1:100. Thus, Yi-Fu-Qing granule may have a significant antivirus effect on acute respiratory tract infections with RSV and Ad3 infections and this could prove useful for further antivirus research on acute respiratory tract infections.

  13. Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia.

    Science.gov (United States)

    Makinodan, Manabu; Yamauchi, Takahira; Tatsumi, Kouko; Okuda, Hiroaki; Noriyama, Yoshinobu; Sadamatsu, Miyuki; Kishimoto, Toshifumi; Wanaka, Akio

    2009-01-01

    The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.

  14. Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia

    Directory of Open Access Journals (Sweden)

    Manabu Makinodan M.D.

    2009-01-01

    Full Text Available The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.

  15. Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

    Directory of Open Access Journals (Sweden)

    Wu Dong-Feng

    2011-02-01

    Full Text Available Abstract Background Several common genetic polymorphisms in the low density lipoprotein receptor (LDL-R gene have associated with modifications of serum total cholesterol (TC and low density lipoprotein cholesterol (LDL-C levels, but the results are not consistent in different populations. Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 1024 subjects of Bai Ku Yao and 792 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples. Genotyping of the LDL-R gene Ava Ⅱ polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. Results The levels of serum TC, high density lipoprotein cholesterol (HDL-C, LDL-C, apolipoprotein (Apo A1 and the ratio of ApoA1 to ApoB were lower in Bai Ku Yao than in Han (P - and A+ alleles was 65.5% and 34.5% in Bai Ku Yao, and 80.7% and 19.3% in Han (P -A-, A-A+ and A+A+ genotypes was 42.6%, 45.9% and 11.5% in Bai Ku Yao, and 64.9%, 31.6% and 3.5% in Han (P P 3.20 mmol/L subgroups in Bai Ku Yao (P P P P +A+ genotype had higher serum LDL-C, TC, HDL-C or ApoA1 levels than the subjects with A-A+ and A-A- genotypes. Spearman rank correlation analysis revealed that the levels of LDL-C in Bai Ku Yao and HDL-C in Han were correlated with genotypes (P P Conclusions The association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations. The discrepancy might partly result from different LDL-R gene Ava Ⅱ polymorphism or LDL-R gene-enviromental interactions.

  16. Prevalence of overweight and obesity among Chinese Yi nationality: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Gao Yun

    2011-12-01

    Full Text Available Abstract Background Overweight and obesity are considered a serious health problem. There are little data on the prevalence of overweight and obesity among the Yi ethnic group in China. This study aimed to investigate the epidemiologic features of overweight/obesity among Chinese Yi nationality. Methods A cross-sectional study, including 1255 subjects aged 20-75 years, was carried out in Liangshan Yi Autonomous Prefecture of Sichuan province from 2007 to 2008. Overweight/overall obesity was defined by World Health Organization (WHO or the Working Group on Obesity in China. Results Overall, the prevalence of overweight and obesity was 19.0% and 2.9%, respectively, based on the WHO definition, while it was 21.0% and 7.4%, respectively, according to the Working Group on Obesity in China, which is similar to data reported in the 2002 Chinese National Nutrition and Health Survey. Urban residents had a significantly higher prevalence of obesity (WHO criteria: 4.3% vs 1.7% p = 0.008; China criteria: 11.4% vs 3.7%, p p p Conclusions The prevalence of overweight/obesity in the Yi nationality is similar to that in Chinese adults 5 years ago. However, urban residents have a much higher prevalence of overweight/obesity than their rural counterparts. Lifestyle and diet patterns associated with socioeconomic status may explain the difference between urban and rural residents. The prevention of overweight/obesity among urban inhabitants deserves more attention in national health education programs.

  17. Of Canons and Commodities: The Cultural Predicaments of Nuosu-Yi “Bimo Culture”

    OpenAIRE

    Olivia Kraef

    2014-01-01

    "The Nuosu are a subgroup of the so-called Yi ethnic group. Today around two million Nuosu live in Liangshan Autonomous Prefecture in Sichuan Province and translocal urban contexts, such as Chengdu and Beijing. For many centuries, the Nuosu have cultivated a belief system composed of a combination of animism and ancestor worship. Since the resurrection of religious activity across China that began in the early 1980s, this faith - represented by the three types of religious practitioners known...

  18. 汉魏石经杂考%Miscellaneous Research on Han and Wei Stone Classics

    Institute of Scientific and Technical Information of China (English)

    王东洋

    2017-01-01

    汉魏石经包括东汉熹平石经、《典论》石经和正始石经,三者均开刻于当时的京城洛阳,在中国文化史上具有重要意义。汉魏石经由朝廷下诏刊刻,立于太学,供天下儒生观瞻临摹。在纸质书写材料尚未普及的汉魏时期,汉魏石经起到了统一经学、保存文化、宣扬教化的作用。%Han and Wei Stone Classics with Xiping Stone classics,Dianlun Stone classics and Zhengshi Stone classics were carved in Luoyang City,has great significance in the history of Chinese culture.Under the royal order,Han and Wei Stone Classics were inscribed and erected in the Imperial College for the confucian scholars to learn and copy.In view of the underpopularization of paper writing material,Han and Wei Stone Classics played the role of unifying confucian classics,preserving culture and preaching and teaching.

  19. Simulation of blue and green water resources in the Wei River basin, China

    Directory of Open Access Journals (Sweden)

    Z. Xu

    2014-09-01

    Full Text Available The Wei River is the largest tributary of the Yellow River in China and it is suffering from water scarcity and water pollution. In order to quantify the amount of water resources in the study area, a hydrological modelling approach was applied by using SWAT (Soil and Water Assessment Tool, calibrated and validated with SUFI-2 (Sequential Uncertainty Fitting program based on river discharge in the Wei River basin (WRB. Sensitivity and uncertainty analyses were also performed to improve the model performance. Water resources components of blue water flow, green water flow and green water storage were estimated at the HRU (Hydrological Response Unit scales. Water resources in HRUs were also aggregated to sub-basins, river catchments, and then city/region scales for further analysis. The results showed that most parts of the WRB experienced a decrease in blue water resources between the 1960s and 2000s, with a minimum value in the 1990s. The decrease is particularly significant in the most southern part of the WRB (Guanzhong Plain, one of the most important grain production basements in China. Variations of green water flow and green water storage were relatively small on the spatial and temporal dimensions. This study provides strategic information for optimal utilization of water resources and planning of cultivating seasons in the Wei River basin.

  20. Effect of WeiJia on carbon tetrachloride induced chronic liver injury

    Science.gov (United States)

    Cheung, Pik-Yuen; Zhang, Qi; Zhang, Ya-Ou; Bai, Gan-Rong; Lin, Marie Chia-Mi; Chan, Bernard; Fong, Chi-Chun; Shi, Lin; Shi, Yue-Feng; Chun, Jay; Kung, Hsiang-Fu; Yang, Mengsu

    2006-01-01

    AIM: To study the effect of WeiJia on chronic liver injury using carbon tetrachloride (CCl4) induced liver injury animal model. METHODS: Wistar rats weighing 180-220g were randomly divided into three groups: normal control group (Group A), CCl4 induced liver injury control group (Group B) and CCl4 induction with WeiJia treatment group (Group C). Each group consisted of 14 rats. Liver damage and fibrosis was induced by subcutaneous injection with 40% CCl4 in olive oil at 3 mL/kg body weight twice a week for eight weeks for Groups B and C rats whereas olive oil was used for Group A rats. Starting from the third week, Group C rats also received daily intraperitoneal injection of WeiJia at a dose of 1.25 μg/kg body weight. Animals were sacrificed at the fifth week (4 male, 3 female), and eighth week (4 male, 3 female) respectively. Degree of fibrosis were measured and serological markers for liver fibrosis and function including hyaluronic acid (HA), type IV collagen (CIV), γ-glutamyl transferase (γ-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Alpha smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) immunohistochemistry were also performed. RESULTS: CCl4 induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV, ALT, AST and γ-GT levels after eight weeks of treatment for Group C rats were 58±22 µg/L (P0.05) respectively, similar to normal control group (Group A), but significantly different from CCl4 induced liver injury control group (Group B). An increase in PCNA and decrease in α-SMA expression level was also observed. CONCLUSION: WeiJia could improve liver function and reduce liver

  1. [A review for a traditional Chinese medical journal Shou Shi Yi Bao].

    Science.gov (United States)

    Xiao, Mei-Hua; Sun, Wen-Zhong

    2009-06-01

    Shou Shi Yi Bao was a journal of traditional Chinese medicine (TCM) during the period from 1935 to 1937, and was originated by Chen Huan-yun, a TCM physician in Suzhou. It is mainly to transmit the knowledge of TCM and to promote the epidemic prevention capacity of local public. The editorial characteristics and historical value of the journal were explored in initial background, staff writers, editorial policies, contents and the Editor Chen's medical ideas. Shou Shi Yi Bao was supported by many famous TCM physicians, although the journal was originated from the civil society. It was an academic TCM journal with perfect practicability for orientating to the public and highlighting the academic spirit. Chen Huan-yun was a resolute defender of TCM, and had many opinions on clinical practice and lots of scientific suggestions on TCM development. Shou Shi Yi Bao reflected the main characteristics of TCM journals in 1930s. The journal was one of the important documents to study the TCM history during the period of the Republic of China in Jiangsu Province, and it also set a stage for the struggle between TCM and Western medicine at that time. The documentary information of the journal has literature and history values in reflecting the historical process of TCM self-improvement. The success of the journal was due to not only the broken-up sectarian bias and cooperation of the TCM practitioners but also the preponderant geographic and cultural circumstances of Suzhou as well as Chen Huan-yun's profound knowledge in traditional Chinese culture and medicine.

  2. [A population survey of the Yi nationality in Meigu County, Sichuan Province].

    Science.gov (United States)

    Wang, D; Zhang, G

    1984-01-29

    In 1980, 95.35% of the 129,819 inhabitants of Meigu County in Faxin District of the Jinshan Yi autonomous district, Sichuan Province, were of Yi nationality. Agriculture is the primary mode of production and animal husbandry is an important secondary industry. Prior to Liberation, slavery was an integral part of Yi society. The standard of living was low, mortality high, and population growth slow. After Liberation from 1956-1980, the population grew 47.1%, 90% of which was a natural increase. The primary reason for the growth was a post-1960s annual average birth rate of 46/1000 and a mortality rate that fell from 35/1000 before Liberation to 13.3/1000 in 1976. The age structure also became younger. The average age in 1964 was 24 years, with a median age of 21.8 years, as compared to a 1980 average age of 23.8 years and a median age of 17 years. 47.2% of the population were aged from birth to 14 years; 2.9% were over 65 years. At the same time, 28% of the female population were of childbearing age. By 2000 Meigu County's population will reach 259,000. Although the primary reasons for the relatively rapid population increase are due to the destruction of the slave system and a higher standard of living, factors peculiar to Yi society are also significant: 1) the destruction of the slave system permitted the population to grow without the restraints of strict codes of class stratification; 2) the high value placed on having many offsprings, and of favoring male children still prevails; 3) the attitude of early marriage and the custom of widows marrying a relative of her deceased husband still prevail; 4) and infant mortality and the mortality rate of fertile women have declined. Elements which influence the population development of Meigu County include economic factors such as the need to support the old and the young, or the inability to produce enough food to keep up with the needs of an expanding population.

  3. The innovation and tradition of science: centennial of academician Ho Zah-Wei

    International Nuclear Information System (INIS)

    Liu Xiao

    2014-01-01

    This article reviews Mrs. Ho Zah-Wei's academic experiences in several different aspects. She inherited the idea of 'Saving the Nation by Science' from older scholars such as Cai Yuanpei. Receiving advanced scientific education and discipline, she made the important innovation through international communication and collaboration. After returned to China, She took part in the foundation of the Chinese nuclear science, assembled and trained many prominent scientists. To commemorate her centennial, we should not only cherish her scientific innovation and undertaking, but also develop her scientific spirit and tradition. (authors)

  4. Essay: The Yi and the Internet: Promoting Ethnicity and Ethnic Identity in Chinese Virtuality

    Directory of Open Access Journals (Sweden)

    Kraef, Olivia

    2013-03-01

    Full Text Available Since the turn of the century China has witnessed an unparalleled development of internet sites, blogs, chat forums, and corresponding virtual communities. These virtual platforms have become important nodes for information and networking, especially in light of economic and intellectual migration and the corresponding trans-local quality of relationships and networks, and contribute to a further diversification of China’s cultural landscape. China’s ethnic minorities, too, have been employing internet platforms as a means to promote, and to reflect on, their own culture. For some groups these platforms signify an extension of early, non-virtual ethnic networks and platforms in urban contexts, which provide a renewed incentive for the affirmation of ethnicity/ethnic identity by engaging netizens in an ongoing dialogue on ethnic cultural contents, which transcends physical space. The article introduces two major internet platforms of the so-called Yi minority, www.yizuren.com and http://yizucn.com, and probes into their potential for ethnic identity promotion, and into general parameters of the relationship between the Yi and the internet.

  5. Dying Hunters, Poison Plants, and Mute Slaves-Nature and Tradition in Contemporary Nuosu Yi Poetry

    Directory of Open Access Journals (Sweden)

    Mark Bender

    2009-06-01

    Full Text Available Themes of nature and traditional culture are common in the works of ethnic poets from a subgroup of the large Yi 彝 ethnic group of southwest China known as the Nuosu 诺苏. Nuosu culture is synonymous with the Liangshan 凉山 Mountains of southern Sichuan 四川 Province. Since the 1980s several dozen Nuosu poets have emerged to form what can be called the 'Liangshan School' of contemporary Chinese poetry. Drawing on theory from Ethnopoetics, Ecoliterature, and Folkloristics the paper introduces major themes in the works of these Nuosu poets and introduces poems by three poets who distinctly utilize nature imagery from a common pool of Yi cultural traditions. These traditions include oral literature, ritual, folk costume, and traditional ideas about social hierarchy and gender relations. Much of the nature imagery is related to folk knowledge of native animals and plants. A major theme in the poetry is the response to changes in tradition and the local environment brought about by rapid growth and development in China.

  6. Alteration of radiation-induced hematotoxicity by Bu-Zhong-Yi-Qi-Tang in mouse

    International Nuclear Information System (INIS)

    Jang, Jong Sik; Kim, Sung Ho

    2008-01-01

    The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocytes. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients

  7. Alteration of radiation-induced hematotoxicity by Bu-Zhong-Yi-Qi-Tang in mouse

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Jong Sik [Kyungpook National University, Daegu (Korea, Republic of); Kim, Sung Ho [Chonnam National University, Gwangju (Korea, Republic of)

    2008-09-15

    The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocytes. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients.

  8. A remarkable new species of Nemoura (Plecoptera: Nemouridae) from Chuxiong Yi Autonomous Prefecture of Yunnan Province, China.

    Science.gov (United States)

    Qian, Yu-Han; Xiao, Qian; Chen, Zhi-Teng; Du, Yu-Zhou

    2018-01-24

    A new species of the genus Nemoura, N. latilongispina sp. nov. from Chuxiong Yi Autonomous Prefecture of Yunnan Province, southwestern China is described and illustrated. The new species is characterized by ventral sclerite of epiproct extended laterally, forming upcurved plates fringed with long spines along upper margin, and by the strongly sclerotized, fork-shaped cercus.

  9. Effects of Capsule Yi -Zhi on learning and memory disorder and beta-amyloid peptide induced neurotoxicity in rats

    Institute of Scientific and Technical Information of China (English)

    XUJiang-Ping; WUHang-Yu; LILin

    2004-01-01

    AIM To investigate the effects of Capsule Yi-Zhi (CYZ) on learning and memory disorder and beta-amyloid protein induced neurotoxieity in rats. Methods Various doses of CYZ were administered to Sprague-Dawley (SD) rats for 8 days, twice a day. Then scopolamine hydrobromide (Sco) intraperitoneal injection was performed on each rat and the

  10. Detecting Abrupt Change of Streamflow at Lintong Station of Wei River

    Directory of Open Access Journals (Sweden)

    Jingjing Fan

    2013-01-01

    Full Text Available According to abrupt diagnosis of runoff, two methods, that is, moving approximate entropy and moving permutation entropy, are used to analyse the abrupt year of the daily river runoff from 1961 to 2006 at Lintong station of Wei River in Loess Plateau. The runoff series are divided into 4 stages. With the analysis of hydrological characters of different stages, we find that there are abrupt changes at the three years 1972, 1983, and 2002. The result shows that moving approximate entropy and moving permutation entropy methods are useful tools for abrupt diagnosis of runoff. The attribution of abrupt change at the Lintong runoff series is primarily due to the reduced precipitation, increased water conservancy project, increased water consumption of industry and agriculture, significantly decreased groundwater table, and increased evaporation.

  11. Calculation of Hydrodynamic Characteristics of Weis-Fogh Type Water Turbine Using the Advanced Vortex Method

    International Nuclear Information System (INIS)

    Ro, Ki Deok

    2014-01-01

    In this study, the hydrodynamic characteristics of Weis-Fogh type water turbine were calculated by the advanced vortex method. The wing (NACA0010 airfoil) and both channel walls were approximated by source and vortex panels, and free vortices are introduced away from the body surfaces. The distance from the trailing edge of the wing to the wing axis, the width of the water channel and the maximum opening angle were selected as the calculation parameters, the important design factors. The maximum efficiency and the power coefficient for one wing of this water turbine were 26% and 0.4 at velocity ratio U/V = 2.0 respectively. The flow field of this water turbine is very complex because the wing moves unsteadily in the channel. However, using the advanced vortex method, it could be calculated accurately

  12. Study on Strata Behavior Regularity of 1301 Face in Thick Bedrock of Wei - qiang Coal Mine

    Science.gov (United States)

    Gu, Shuancheng; Yao, Boyu

    2017-09-01

    In order to ensure the safe and efficient production of the thick bedrock face, the rule of the strata behavior of the thick bedrock face is discussed through the observation of the strata pressure of the 1301 first mining face in Wei qiang coal mine. The initial face is to press the average distance of 50.75m, the periodic weighting is to press the average distance of 12.1m; during the normal mining period, although the upper roof can not be broken at the same time, but the pressure step is basically the same; the working face for the first weighting and periodical weighting is more obvious to the change of pressure step change, when the pressure of the working face is coming, the stent force increased significantly, but there are still part of the stent work resistance exceeds the rated working resistance, low stability, still need to strengthen management.

  13. Calculation of Hydrodynamic Characteristics of Weis-Fogh Type Water Turbine Using the Advanced Vortex Method

    Energy Technology Data Exchange (ETDEWEB)

    Ro, Ki Deok [Gyeongsang Nat' l Univ., Jinju (Korea, Republic of)

    2014-03-15

    In this study, the hydrodynamic characteristics of Weis-Fogh type water turbine were calculated by the advanced vortex method. The wing (NACA0010 airfoil) and both channel walls were approximated by source and vortex panels, and free vortices are introduced away from the body surfaces. The distance from the trailing edge of the wing to the wing axis, the width of the water channel and the maximum opening angle were selected as the calculation parameters, the important design factors. The maximum efficiency and the power coefficient for one wing of this water turbine were 26% and 0.4 at velocity ratio U/V = 2.0 respectively. The flow field of this water turbine is very complex because the wing moves unsteadily in the channel. However, using the advanced vortex method, it could be calculated accurately.

  14. From “Customary” to “Illegal”: Yao Ethnic Marriages on the Sino-Vietnamese Border

    Directory of Open Access Journals (Sweden)

    Elena Barabantseva

    2015-06-01

    Full Text Available This article examines changing governing practices in the context of the Sino-Vietnamese border in the Guangxi Autonomous Region of China. The groups inhabiting the mountainous ranges of this ethnically diverse part of Southeast Asia evaded the reach of the state until the 1970s, when China and Vietnam started tightening control over the land border after the border war. With an increasingly rigid and clearly delimited Sino-Vietnamese borderland, binary forms of classification began to replace earlier fluid identifications, and the room for diverse social and cultural expressions became restricted. It is within this context that the ethnic marriage practices straddling the borders of China and its southern neighboring states discussed in this article took place. Cross-border ethnic Yao marriages have gone from customary to illegal in recent years as a result of China’s strict population control, its changing demography, and the accelerated shortage of manual labor in its border area. Border politics have permeated the private sphere, transforming common ethnic marriage partners into illegal migrants. Although ethnic marriage partners are relegated to an illegal status, they are indispensible in the local labor market and moral economy as mothers, caretakers, translators, guides, and manual workers. This article argues that, despite being antithetical to the bordering logic of state sovereignty, they are important agents who depend on and capitalize on the border economy.

  15. Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain.

    Science.gov (United States)

    Huang, Shuning; Farrar, Christian T; Dai, Guangping; Kwon, Seon Joo; Bogdanov, Alexei A; Rosen, Bruce R; Kim, Young R

    2013-04-01

    The integrity of the blood-brain barrier (BBB) is critical to normal brain function. Traditional techniques for the assessment of BBB disruption rely heavily on the spatiotemporal analysis of extravasating contrast agents. However, such methods based on the leakage of relatively large molecules are not suitable for the detection of subtle BBB impairment or for the performance of repeated measurements in a short time frame. Quantification of the water exchange rate constant (WER) across the BBB using strictly intravascular contrast agents could provide a much more sensitive method for the quantification of the BBB integrity. To estimate WER, we have recently devised a powerful new method using a water exchange index (WEI) biomarker and demonstrated BBB disruption in an acute stroke model. Here, we confirm that WEI is sensitive to even very subtle changes in the integrity of the BBB caused by: (i) systemic hypercapnia and (ii) low doses of a hyperosmolar solution. In addition, we have examined the sensitivity and accuracy of WEI as a biomarker of WER using computer simulation. In particular, the dependence of the WEI-WER relation on changes in vascular blood volume, T1 relaxation of cellular magnetization and transcytolemmal water exchange was explored. Simulated WEI was found to vary linearly with WER for typically encountered exchange rate constants (1-4 Hz), regardless of the blood volume. However, for very high WER (>5 Hz), WEI became progressively more insensitive to increasing WER. The incorporation of transcytolemmal water exchange, using a three-compartment tissue model, helped to extend the linear WEI regime to slightly higher WER, but had no significant effect for most physiologically important WERs (WER < 4 Hz). Variation in cellular T1 had no effect on WEI. Using both theoretical and experimental approaches, our study validates the utility of the WEI biomarker for the monitoring of BBB integrity. Copyright © 2012 John Wiley & Sons, Ltd.

  16. The investigation of anti-inflammatory activity of Yi Guanjian decoction by serum metabonomics approach.

    Science.gov (United States)

    Shui, Sufang; Cai, Xiaorong; Huang, Rongqing; Xiao, Bingkun; Yang, Jianyun

    2017-01-30

    Yi Guanjian (YGJ), one of the Chinese herbal medicines most commonly used in western countries, reported to possess significant anti-inflammatary effects that inhibit the process of inflammation. However, the mechanisms underlying its anti-inflammation effects remain largely unresolved. This study was aimed to investigate the anti-inflammatory activity of YGJ and to explore its potential anti-inflammatory mechanisms by serum metabonomics approach. An xylene-induced mouse right-ear-edema model was used as an inflammatory response in vivo model. Ear edema, prostaglandin E2 (PGE 2 ) and Tumor-Necrosis-Factor-alpha (TNF-α) were detected. Then, serum metabolic profiling was analyzed and pathway analysis performed on the biomarkers reversed after YGJ administration and further integration of metabolic networks. The results showed that YGJ alleviated ear edema and decreased serum PGE 2 and TNF-α levels. Fourteen biomarkers were screened, and the levels were all reversed to different degrees after YGJ administration. These biomarkers were mainly related to linoleic acid metabolism, taurine and hypotaurine metabolism, glyoxylate and dicarboxylate metabolism, glycine, serine and threonine metabolism and citrate cycle (TCA cycle). In metabolic networks, glycine and pyruvate were node molecules. This indicated that YGJ could significantly inhibit inflammatory response triggered by acute local stimulation and exerted anti-inflammatory activity mainly by regulating node molecules. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. [The innovation of warm disease theory in the Ming Dynasty before Wen yi lun On Pestilence].

    Science.gov (United States)

    Zhang, Zhi-bin

    2008-10-01

    Some doctors of the Ming dynasty raised subversive doubts against the traditional viewpoints of "exogenous cold disease is warm-heat" before the emergence of Wen yi lun (On Pestilence), holding that warm-heat disease "is contracted in different seasons instead of being transformed from cold to warm and/or heat". The conception of the separation of warm-heat disease and exogenous cold disease had changed from obscure to clear. As the idea became clear, the recognition on the new affection of warm, heat, summer-heat, pestilent pathogen was formed, and the idea that the pathogens of summer-heat and warm entered the human body through the mouth and nostrils was put forward. The six-channel syndrome differentiation of warm disease and the five sweat-resolving methods in pestilence raised by the doctors of this period are the aspects of the differential diagnosis of syndrome and treatment in warm diseases, and deserve to be paid attention to.

  18. Regional Frequency Analysis of Extreme Dry Spells during Rainy Season in the Wei River Basin, China

    Directory of Open Access Journals (Sweden)

    Dunxian She

    2016-01-01

    Full Text Available Our research analyzes the regional changes of extreme dry spell, represented by the annual maximum dry spell length (noted as AMDSL during the rainy season in the Wei River Basin (WRB of China for 1960–2014 using the L-moments method. The mean AMDSL values increase from the west to the east of the WRB, suggesting a high dry risk in the east compared to the west in the WRB. To investigate the regional frequency more reasonably, the WRB is clustered into four homogenous subregions via the K-means method and some subjective adjustments. The goodness-of-fit test shows that the GEV, PE3, and GLO distribution can be accepted as the “best-fit” model for subregions 1 and 4, subregion 2, and subregion 3, respectively. The quantiles of AMDSL under various return levels figure out a similar spatial distribution with mean AMDSL. We also find that the dry risk in subregion 2 and subregion 4 might be higher than that in subregion 1. The relationship between ENSO events and extreme dry spell events in the rainy season with cross wavelet analysis method proves that ENSO events play a critical role in triggering extreme dry events during rainy season in the WRB.

  19. Visualization of Flow Field of Weis-Fogh Type Water Turbine Using the PIV

    Energy Technology Data Exchange (ETDEWEB)

    Ro, Ki Deok [Gyeongsang Nat’l Univ., Jinju (Korea, Republic of)

    2017-03-15

    In this study, the visualization of the unsteady flow field of a Weis-Fogh-type water turbine was investigated using particle-image velocimetry. The visualization experiments were performed in a parameter range that provided relatively high-efficiency wing conditions, that is, at a wing opening angle α= 40 .deg. and at a velocity ratio of the uniform flow to the moving wing U/V = 1.5~2.5. The flow fields at the opening, translational, and closing stages were investigated for each experimental parameter. In the opening stage, the fluid was drawn in between the wing and wall at a velocity that increased with an increase in the opening angle and velocity ratio. In the translational stage, the fluid on the pressure face of the wing moved in the direction of the wing motion, and the boundary layer at the back face of the wing was the thinnest and had a velocity ratio of 2.0. In the closing stage, the fluid between the wing and wall was jetted at a velocity that increased as the opening angle decreased; however, the velocity was independent of the velocity ratio.

  20. Drought Characteristic Analysis Based on an Improved PDSI in the Wei River Basin of China

    Directory of Open Access Journals (Sweden)

    Lei Zou

    2017-03-01

    Full Text Available In this study, to improve the efficiency of the original Palmer Drought Severity Index (PDSI_original, we coupled the Soil and Water Assessment tool (SWAT and PDSI_original to construct a drought index called PDSI_SWAT. The constructed PDSI_SWAT is applied in the Wei River Basin (WRB of China during 1960–2012. The comparison of the PDSI_SWAT with four other commonly used drought indices reveals the effectiveness of the PDSI_SWAT in describing the drought propagation processes in WRB. The whole WRB exhibits a dry trend, with more significant trends in the northern, southeastern and western WRB than the remaining regions. Furthermore, the drought frequencies show that drought seems to occur more likely in the northern part than the southern part of WRB. The principle component analysis method based on the PDSI_SWAT reveals that the whole basin can be further divided into three distinct sub-regions with different drought variability, i.e., the northern, southeastern and western part. Additionally, these three sub-regions are also consistent with the spatial pattern of drought shown by the drought frequency. The wavelet transform analysis method indicates that the El Niño-Southern Oscillation (ENSO events have strong impacts on inducing droughts in the WRB. The results of this study could be beneficial for a scientific water resources management and drought assessment in the current study area and also provide a valuable reference for other areas with similar climatic characteristics.

  1. Effects of Compound Yi-Zhi on D-galactose-induced learning and memory deficits in mice

    Institute of Scientific and Technical Information of China (English)

    XUJiang-Ping; WUHang-Yu; LILin

    2004-01-01

    AIM: To explore the effects of Compound Yi-Zhi (YZC) on learning and memory capacity and free radical metabolism in D-galactose induced mice dementia model. METHODS: The mice dementia model was induced by a daily D-galactose 0.15g/kg sc for 45 days and after 5 days'D-galactose injection, the mice were treated with three doses of YZC

  2. Wei Man is a Chinese, not a Korean%论卫满是中国人而非朝鲜人

    Institute of Scientific and Technical Information of China (English)

    吴彦勤

    2001-01-01

    In BC194, WeiMan,a rebel in Yan region ,escaped to Korea and came to the throne in the locality. Jin Zhenpei,a scholor of RK, considers the majority of people in Yan region belong to the Mo nation, Which is one of ancient nations evolving to Korean;then Jin concludes WeiMan belongs to "Korean system". This thesis retorts his opinion. Indeed, the Mo nation is one of nations hich had evolved to Korean,but the great majority of them in China had fused into Various nations of north China and become the ingredient of the Chinese natioin.It's erroneous to identify the Mo nation with "Korean system".No matter whether WeiMan and Yan's refugees belong to the Mo nation or not,they are Chinese. It can' t be denied that WeiMan Korea contained Chinese constituent.%本文就韩国学者金贞培在其《韩国民族的文化和起源》一书中关于因燕国境内多为貊族,从而认定卫满及燕满亡民为"朝鲜人系统"的观点展开论述。本文认为民族是一个历史的范畴,许多古代民族不断分化融合到其他民族中去,并成为这其他民族不可分割的一部份,因而将貊族完全认为"朝鲜人系统"是错误的。无论卫满和燕满是不是貊族,他们都是中国人;卫满朝鲜的成份是不容否认的。

  3. Using the WEIS-SR to evaluate employee perceptions of their college work environment.

    Science.gov (United States)

    Dorsey, Julie; Kaye, Miranda; Barratt, Jennifer; Biondi, Jennifer; Habrial, Amanda; Lane, Amanda; Marinelli, Victoria; Paulino, Tiffany; Singletary, Amanda

    2016-04-06

    Colleges have been experiencing reduced resource allocations, shifting student expectations, and organizational change. These changes increase employee stress at all levels. Ensuring that employee needs are being met and promoting a healthy and productive workforce has never been more important. To investigate employees' current perceptions of their work environments using the Work Environment Impact Scale-Self Rating (WEIS-SR). Full and part time employees on a small college campus in the United States were surveyed using the WEIS-SR through an online survey program to protect their anonymity. Perception of staffing levels, workplace support for a healthy lifestyle, number of supervisors, and personal health ratings contributed to employee perceptions of their work environment. There were also differences between staff, administration, and tenured and non-tenured faculty. From an occupational performance perspective, valuable information on employees' levels of volition, performance capacity and habituation, and perceptions of their physical and social environment in relation to their work environments was obtained. Further support for the use of the WEIS-SR and psychometric properties of the instrument (reliability and validity) was obtained.

  4. [Single nucleotide polymorphisms of HIV coreceptor CCR5 gene in Chinese Yi ethnic group and its association with HIV infection].

    Science.gov (United States)

    Ma, Li-ying; Hong, Kun-xue; Lu, Xiao-zhi; Qin, Guang-ming; Chen, Jian-ping; Chen, Kang-lin; Ruan, Yu-hua; Xing, Hui; Zhu, Jia-hong; Shao, Yi-ming

    2005-11-30

    To investigate the single nucleotide polymorphism (SNP) of HIV-1 coreceptor CCR5 gene in Chinese Yi ethnic group and the association between these SNPs and HIV/AIDS. Peripheral blood samples of 102 HIV negative persons of Chinese Yi nationality, 87 males amd 15 females, aged 23 (12-37), and 68 HIV carriers, 61 males and 7 females, aged 27 (17-51). The regulatory and structural regions of the HIV coreceptor CCR5 gene were amplified from the genomic DNA by nested PCR, each of the two regions was divided into three gene fragments which were overlapped. High throughput DHPLC was used for screening of unknown mutations in each gene fragment. The PCR products showing different peak traces from wild types in DHPLC were sequenced by forward and reverse primers respectively. The sequences were analyzed with the help of Sequence Navigator software to search for SNP loci. Statistical analysis by SPSS and PPAP softwares were made to study the association between these SNPs and HIV infection. Five SNPs (A77G, G316A, T532C, C921T, and G668A) and a AGA deletion of the 686-688 nucleotides were discovered in the coding region of this gene in Chinese Yi ethnic group. C921T mutation was a nonsense mutation, and the other SNPs (A77G, G316A, T532C, and G668A) are sense mutation, with the amino acid changes of K26R, G106R, C178R, and R223Q. Only the frequency of R223Q allelic gene was high (0.08) but those of the others were low (less than 0.01). There was no significant difference in the allele frequency between the HIV negative and HIV positive groups (all P > 0.05). Five SNP loci (T58934G, G59029A, T59353C, G59402A, and C59653T) were found in the regulatory region of CCR5 gene with high allelic frequencies of 0.1912-0.2941. Between the HIV negative and HIV positive groups, there were no differences in the SNP loc (all P > 0.05). Statistical analysis of the association between the linkage of mutation loci with HIV infection suggested a significant difference in the haplotype frequency

  5. Impact of climate change and anthropogenic activities on stream flow and sediment discharge in the Wei River basin, China

    Directory of Open Access Journals (Sweden)

    P. Gao

    2013-03-01

    Full Text Available Reduced stream flow and increased sediment discharge are a major concern in the Yellow River basin of China, which supplies water for agriculture, industry and the growing populations located along the river. Similar concerns exist in the Wei River basin, which is the largest tributary of the Yellow River basin and comprises the highly eroded Loess Plateau. Better understanding of the drivers of stream flow and sediment discharge dynamics in the Wei River basin is needed for development of effective management strategies for the region and entire Yellow River basin. In this regard we analysed long-term trends for water and sediment discharge during the flood season in the Wei River basin, China. Stream flow and sediment discharge data for 1932 to 2008 from existing hydrological stations located in two subcatchments and at two points in the Wei River were analysed. Precipitation and air temperature data were analysed from corresponding meteorological stations. We identified change-points or transition years for the trends by the Pettitt method and, using double mass curves, we diagnosed whether they were caused by precipitation changes, human intervention, or both. We found significant decreasing trends for stream flow and sediment discharge during the flood season in both subcatchments and in the Wei River itself. Change-point analyses further revealed that transition years existed and that rapid decline in stream flow began in 1968 (P P P P P < 0.05, respectively. The impact of precipitation or human activity on the reduction amount after the transition years was estimated by double mass curves of precipitation vs. stream flow (sediment. For reductions in stream flow and sediment discharge, the contribution rate of human activity was found to be 82.80 and 95.56%, respectively, and was significantly stronger than the contribution rate of precipitation. This evidence clearly suggests that, in the absence of significant decreases in precipitation

  6. YI Kwang Su's Love and history records of modern hospital under the japanese colonial period.

    Science.gov (United States)

    Lee, Byoung Hoon

    2016-12-01

    This article aims to evaluate and analyze the description of the modern hospital as history record, which appeared in YI Kwang Su's novel Love. This novel has mentioned in detail western style clinic, Bukgando Catholic hospital, tuberculosis sanitarium as its main space. Modern hospitals are depicted in the novel has a great significance in historical aspect as well as in literary aspect. The most data on modern hospital is laws, statistics and newspaper archives. These materials are a great help to understand the history and status of the modern hospital. Literary description here is important materials, that specific to reconstruct the appearance of the modern hospital at that time. Literary representations infuse life into the history record. In this regard, Love has special meaning in the history of Korean modern literature. Before anything else, doctor AN Bin's clinic as a first space of the novel vividly shows the reality of the Western style clinic and a general practitioner under the colonial period. The establishment of the hospital was based on 「Rules on private hospital」 declared by the Japanese Government General of Korea in 1919. According to this Rules, a private clinic's founder had to submit the documents to the director of police affairs, in which all the details were written. It included name of hospital, site location and size, floor plan of a nearby building, each size of patient's rooms, number of steps and emergency exit, bath, toilet, disinfecting room. AN Bin's clinic was a private hospital with the requirements in the rules. The descriptions of this clinic re-created real situation of private hospitals, specifically scale of hospital, interior space, conditions of patient's room at the time. The second modern hospital in the novel is Bukgando Catholic hospital. There is a lot more materials on medical activity and hospital of protestant churches than we thought. But we do not have a lot of information on catholic church's medical

  7. A new framework to evaluate ecosystem health: a case study in the Wei River basin, China.

    Science.gov (United States)

    Wu, Wei; Xu, Zongxue; Zhan, Chesheng; Yin, Xuwang; Yu, Songyan

    2015-07-01

    water and watershed management of the Wei River basin, or even the Yellow River basin.

  8. Continuous Yao graphs

    DEFF Research Database (Denmark)

    Bakhshesh, Davood; Barba, Luis; Bose, Prosenjit

    2018-01-01

    Y(π) is not a spanner, and that cY(θ) may be disconnected for θ>π, but on the other hand is always connected for θ⩽π. Furthermore, we show that cY(θ) is a region-fault-tolerant geometric spanner for convex fault regions when θconnected if θ⩽π. Finally, we show that c...

  9. YAO NGUETTIA.pmd

    African Journals Online (AJOL)

    SECRETARIAT

    rainfall less than 1800 mm year-1 and water deficits higher ... Côte d'Ivoire. Keywords : Palm-oil, extraction rate, marginal climatic zone, manual press, rainfall, bunch yield. .... Barima, 2007). Geomorphology of the study area (Barima, 2007).

  10. Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China.

    Science.gov (United States)

    Ye, Jun-jie; Ma, Li; Yang, Li-juan; Wang, Jin-huan; Wang, Yue-li; Guo, Hai; Gong, Ning; Nie, Wen-hui; Zhao, Shu-hua

    2013-09-01

    There are many reports on associations between spermatogenesis and partial azoospermia factor c (AZFc) deletions as well as duplications; however, results are conflicting, possibly due to differences in methodology and ethnic background. The purpose of this study is to investigate the association of AZFc polymorphisms and male infertility in the Yi ethnic population, residents within Yunnan Province, China. A total of 224 infertile patients and 153 fertile subjects were selected in the Yi ethnic population. The study was performed by sequence-tagged site plus/minus (STS+/-) analysis followed by gene dosage and gene copy definition analysis. Y haplotypes of 215 cases and 115 controls were defined by 12 binary markers using single nucleotide polymorphism on Y chromosome (Y-SNP) multiplex assays based on single base primer extension technology. The distribution of Y haplotypes was not significantly different between the case and control groups. The frequencies of both gr/gr (7.6% vs. 8.5%) and b2/b3 (6.3% vs. 8.5%) deletions do not show significant differences. Similarly, single nucleotide variant (SNV) analysis shows no significant difference of gene copy definition between the cases and controls. However, the frequency of partial duplications in the infertile group (4.0%) is significantly higher than that in the control group (0.7%). Further, we found a case with sY1206 deletion which had two CDY1 copies but removed half of DAZ genes. Our results show that male infertility is associated with partial AZFc duplications, but neither gr/gr nor b2/b3 deletions, suggesting that partial AZFc duplications rather than deletions are risk factors for male infertility in Chinese-Yi population.

  11. Clinical Observation on Insomnia Treated by Wei-Defensive Qi-Regulating and Brain-Strengthening Needling Technique

    Institute of Scientific and Technical Information of China (English)

    GAO Xi-yan; LI Xing-rui; MA Qiao-lin; ZHAO Xin-ji; SHAO Su-ju; WEI Yu-long; SUN Wei-xia; HANG Guo-qi

    2007-01-01

    In order to make a report on 90 cases of insomnia treated by the Wei-defensive qi-regulating and brain-strengthening needling technique,as a clinical subject of the multiple center,for assessing the preliminary standardized indications and operating methods and making an initial summary for writing the draft of the technique operation.Methods:By ratio of 1:1,the patients in conformity with the criteria were randomly divided into the experimental group and control group.In the experimental group,45 cases were treated with the Wei-defensive qi-regulating and brain-strengthening needling technique on Baihui (GV 20),Dazhui(GV 14),Shenmai(BL 62),Zhaohai(KI 6),plus ear points.In the control group,45 cases were treated with routine acupuncture on Sishencong(Ex-HN 1),Shenmen (HT 7),Sanyinjiao(SP 6),etc.The therapeutic effects in the two groups were observed and assessed in comparison.Results:The results showed cure in 15 cases.remarkable effect in 27 cases,effect in 42 cases,failure in 6 cases,and the total eriective rate in 94.4% in 90 cases of insomnia.In the three centers,the statistic management was performed based upon PSQI integral and showed significant difference(P<0.01),and no significant difference among various groups(P>0.01).Conclusion:The therapeutic effect in the treatment of insomnia by Wei-defensive qi-regulating and brain-strengthening needling technique is better than the control group and the therapeutic effect and methods in various centers are stable.without any deviation.

  12. The correlational research on the physical mechanical indexes of typical soil collecting from the Xu Wei Lianyungang port

    Science.gov (United States)

    Liu, Wenbin; Wang, Yuanzhan; Liu, Aimin

    2017-11-01

    The tests on the physical mechanical indexes of the reclaimed soft clay are necessary to be done before the foundation strengthening treatment. This paper focus on the study of correlational relationship between the physical mechanical indexes, such as the natural water content, the void ratio, the liquid limit etc., by fitting the data of model test on samples collecting from the Xu Wei Lianyungang port. The linear relationship fitting curve of the physical mechanical indexes is proposed, and these results support the high efficient operation in engineering practice.

  13. Effect of the 3'APOB-VNTR polymorphism on the lipid profiles in the Guangxi Hei Yi Zhuang and Han populations

    Science.gov (United States)

    Ruixing, Yin; Guangqin, Chen; Yong, Wang; Weixiong, Lin; Dezhai, Yang; Shangling, Pan

    2007-01-01

    Background Apolipoprotein (Apo) B is the major component of low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and chylomicrons. Many genetic polymorphisms of the Apo B have been described, associated with variation of lipid levels. However, very few studies have evaluated the effect of the variable number of tandem repeats region 3' of the Apo B gene (3'APOB-VNTR) polymorphism on the lipid profiles in the special minority subgroups in China. Thus, the present study was undertaken to study the effect of the 3'APOB-VNTR polymorphism on the serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations. Methods A total of 548 people of Hei Yi Zhuang were surveyed by a stratified randomized cluster sampling. The epidemiological survey was performed using internationally standardized methods. Serum lipid and apolipoprotein levels were measured. The 3'APOB-VNTR alleles were determined by polymerase chain reaction (PCR) followed by electrophoresis in polyacrylamide gels, and classified according to the number of repeats of a 15-bp hypervariable elements (HVE). The sequence of the most common allele was determined using the PCR and direct sequencing. The possible association between alleles of the 3'APOB-VNTR and lipid variables was examined. The results were compared with those in 496 people of Han who also live in that district. Results Nineteen alleles ranging from 24 to 64 repeats were detected in both Hei Yi Zhuang and Han. HVE56 and HVE58 were not be detected in Hei Yi Zhuang whereas HVE48 and HVE62 were totally absent in Han. The frequencies of HVE26, HVE30, HVE46, heterozygote, and short alleles (VNTR-LS (carrier of one long and one short alleles) than in VNTR-LL (the individual carrying two long alleles) genotypes. The levels of TC, triglycerides (TG), LDL cholesterol, and Apo B in Hei Yi Zhuang were higher in both HVE34 and HVE36 alleles than in HVE32 allele. The levels of TC, TG, HDL-C and Apo B in Hei Yi Zhuang were also higher in

  14. The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study.

    Science.gov (United States)

    Lin, Yi-Rong; Wu, Mei-Yao; Chiang, Jen-Huai; Yen, Hung-Rong; Yang, Su-Tso

    2017-08-29

    Many patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan. We analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626.8) from January 1, 1997 to December 31, 2010. The patients were categorized into TCM seekers and non-TCM seekers according to their use of TCM. Among the subjects, 41,558 (89.69%) were TCM seekers and 4,779 (10.31%) were non-TCM seekers. Patients who were younger tended to be TCM seekers. Most of the patients had also taken Western medicine, especially tranexamic acid and non-steroidal anti-inflammatory drugs (NSAIDs). More than half of TCM seekers (55.41%) received combined treatment with both Chinese herbal remedies and acupuncture. The most commonly used TCM formula and single herb were Jia-Wei-Xiao-Yao-San (Bupleurum and Peony Formula) and Yi-Mu-Cao (Herba Leonuri), respectively. The core pattern of Chinese herbal medicine for DUB patients consisted of Jia-Wei-Xiao-Yao-San, Xiang-Fu (Rhizoma Cyperi), and Yi-Mu-Cao (Herba Leonuri). TCM use is popular among patients with DUB in Taiwan. Further pharmacological investigations and clinical trials are required to validate the efficacy and safety of these items.

  15. Micro tectonic milonitas analysis in the extreme south of the Sarandi del Yi shear zone: Kinematics and deformation conditions

    International Nuclear Information System (INIS)

    Oyhantçabal, P; Suarez, I; Seluchi, N; Martinez, X.

    2010-01-01

    The Shear Zone divides Sarandi del Yi Craton River Plate in Piedra Alta and Nico Perez land . The southern end of this zone extends to north - south from the vicinity of the town of Minas to Punta Solis. The predominant lithology of the study area consists of a granitic mylonite with abundant muscovite and biotite. Structural data of foliation , stretching lineation and kinematic indicators were surveyed .Petrographic analysis shows that quartz is presented as ribbons polycrystalline product subgrain rotation recrystallization and grain boundary migration . Feldspar porphyroclasts are partially recrystallized in developing type structures c ore and mantle . Kinematic indicators such as sigma porphyroclasts , mica fish and oblique foliation defined consistently sinistral sense . The presence of stable and mirmequitas in the plane of biotite foliation along the microstructures described in quartz and feldspar , can be inferred temperature conditions between 450 ° C and 550° C during deformation

  16. Effect of land use on the seasonal variation of streamwater quality in the Wei River basin, China

    Science.gov (United States)

    Yu, S.; Xu, Z.; Wu, W.; Zuo, D.

    2015-05-01

    The temporal effect of land use on streamwater quality needs to be addressed for a better understanding of the complex relationship between land use and streamwater quality. In this study, GIS and Pearson correlation analysis were used to determine whether there were correlations of land-use types with streamwater quality at the sub-basin scale in the Wei River basin, China, during dry and rainy seasons in 2012. Temporal variation of these relations was observed, indicating that relationships between water quality variables and proportions of different land uses were weaker in the rainy season than that in the dry season. Comparing with other land uses, agriculture and urban lands had a stronger relationship with water quality variables in both the rainy and dry seasons. These results suggest that the aspect of temporal effects should be taken into account for better land-use management.

  17. 《采薇》的叙事伦理分析%Narrative Ethics of Cai Wei

    Institute of Scientific and Technical Information of China (English)

    王海燕

    2014-01-01

    The controversial dilemma of how to understand Boyi, Shuqi in Luxun’ s novel Cai Wei, it is not a realistic ethical problem, which should be based on the novel's narrative ethics to answer. Narrative ethics refers to various forms of arrangement of ethical dimension revealed. Novel manifests sympathy ethics to Boyi, Shu Qi through the narrative angle choice and narrative distance controlling. Also, by the counterpoint to character, event and ironic expression in structure, novel conveys the ethics excluding to all sorts of characters from emperor Zhouwu to A Jin. Compared to other “Generational change” theme novels of Luxun, the complication of narrative ethics of Cai Wei not only is the projection of reality, but also reflects the further conscious to narrative art of Luxun.%《采薇》中颇有争议的“如何理解伯夷、叔齐”这一难点,并不是一个现实伦理问题,而应依据小说的叙事伦理来解答。叙事伦理即各种形式安排透露出的伦理维度。小说通过叙事角度的选择与叙事距离的控制体现出对伯夷、叔齐的伦理同情,而由结构上的人物对位与事件对位及反讽表达的是对自周武王至阿金诸色人物的伦理拒斥。与前期同是“易代”主题的小说相比,《采薇》叙事伦理的复杂化既是现实的投射,也体现了鲁迅对于小说叙事艺术的进一步自觉。

  18. I Know You Are, But What Am I? : Anti-Individualism in the Development of Intellectual Humility and Wu-Wei

    NARCIS (Netherlands)

    Robinson, Brian; Alfano, M.R.

    2016-01-01

    Virtues are acquirable, so if intellectual humility is a virtue, it’s acquirable. But there is something deeply problematic—perhaps even paradoxical—about aiming to be intellectually humble. Drawing on Edward Slingerland’s analysis of the paradoxical virtue of wu-wei in Trying Not To Try, we argue

  19. Impact of LUCC on streamflow based on the SWAT model over the Wei River basin on the Loess Plateau in China

    Directory of Open Access Journals (Sweden)

    H. Wang

    2017-04-01

    impact on both soil flow and baseflow by compensating for reduced surface runoff, which leads to a slight increase in the streamflow in the Wei River with the mixed landscapes on the Loess Plateau that include earth–rock mountain area.

  20. [A Study on the quotations in the Wu xing da yi (The Gist of Five Phases) cited from Nei jing (Inner Canon)].

    Science.gov (United States)

    Wang, Zheng-Shan; Zhang, Qi-Cheng

    2013-07-01

    In the Wu xing da yi (The Gist of Five Phases), written by Xiao Ji of the Sui Dynasty, there were 9 quotations cited from Huang di nei jing (Inner Canon of Huangdi). By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages.

  1. Variations in Volatile Oil Yield and Composition of "Xin-yi" (Magnolia biondii Pamp. Flower Buds) at Different Growth Stages.

    Science.gov (United States)

    Hu, Mingli; Bai, Mei; Ye, Wei; Wang, Yaling; Wu, Hong

    2018-06-01

    Dried flower buds of Magnolia biondii Pamp. are the main ingredient in "Xin-yi" in China, and the volatile oils of M. biondii flower buds are the principal medicinal component. Gas chromatographymass spectrometry (GC-MS) and microscopic techniques were employed to detect the volatile yields of M. biondii flowers at various growth stages. The volatile oil yields of M. biondii flowers differed significantly at different growth stages and were closely related to flower dry weight, oil cell density and degree of oil accumulation. In February 2016, flower buds had the highest dry weight, the maximum percentage of oil cells at the oil saturation stage and the highest density of oil cells, which coincided with the highest oil yield. In March 2016, flower buds had a lower dry weight, a higher percentage of oil cells at the oil-degrading stage and the lowest oil cell density, resulting in decreased oil yields. The total amounts of the major medicinal components in the M. biondii flower also showed regular changes at different growth stages. In January and February of 2016, M. biondii flowers had a higher dry weight, volatile oil yield and total content of medicinal ingredients, which was the best time for harvesting high-quality medicinal components. Our study reveals that volatile oil content and chemical composition are closely related to the growth stage of M. biondii flower buds. The results provide a scientific morphology and composition index for evaluating the medicinal value and harvesting of high-quality M. biondii medicinal herbs.

  2. QiShenYiQi Pills, a Compound Chinese Medicine, Prevented Cisplatin Induced Acute Kidney Injury via Regulating Mitochondrial Function

    Directory of Open Access Journals (Sweden)

    Li Zhou

    2017-12-01

    Full Text Available Nephrotoxicity is a serious adverse effect of cisplatin chemotherapy that limits its clinical application, to deal with which no effective management is available so far. The present study was to investigate the potential protective effect of QiShenYiQi Pills (QSYQ, a compound Chinese medicine, against cisplatin induced nephrotoxicity in mice. Pretreatment with QSYQ significantly attenuated the cisplatin induced increase in plasma urea and creatinine, along with the histological damage, such as tubular necrosis, protein cast, and desquamation of epithelial cells, improved the renal microcirculation disturbance as indicated by renal blood flow, microvascular flow velocity, and the number of adherent leukocytes. Additionally, QSYQ prevented mitochondrial dysfunction by preventing the cisplatin induced downregulation of mitochondrial complex activity and the expression of NDUFA10, ATP5D, and Sirt3. Meanwhile, the cisplatin-increased renal thiobarbituric acid-reactive substances, caspase9, cleaved-caspase9, and cleaved-caspase3 were all diminished by QSYQ pretreatment. In summary, the pretreatment with QSYQ remarkably ameliorated the cisplatin induced nephrotoxicity in mice, possibly via the regulation of mitochondrial function, oxidative stress, and apoptosis.

  3. Xiao Yao San Improves Depressive-Like Behaviors in Rats with Chronic Immobilization Stress through Modulation of Locus Coeruleus-Norepinephrine System.

    Science.gov (United States)

    Ding, Xiu-Fang; Zhao, Xiao-Hua; Tao, Yang; Zhong, Wei-Chao; Fan, Qin; Diao, Jian-Xin; Liu, Yuan-Liang; Chen, Yu-Yao; Chen, Jia-Xu; Lv, Zhi-Ping

    2014-01-01

    Most research focuses on the hypothalamic-pituitary-adrenal (HPA) axis, hypothalamus-pituitary-thyroid (HPT) axis, and hypothalamus-pituitary-gonadal (HPGA) axis systems of abnormalities of emotions and behaviors induced by stress, while no studies of Chinese herbal medicine such as Xiao Yao San (XYS) on the mechanisms of locus coeruleus-norepinephrine (LC-NE) system have been reported. Therefore, experiments were carried out to observe mechanism of LC-NE system in response to chronic immobilization stress (CIS) and explore the antidepressant effect of XYS. Rat model was established by CIS. LC morphology in rat was conducted. The serum norepinephrine (NE) concentrations and NE biosynthesis such as tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and corticotrophin-releasing-factor (CRF) in LC were determined. Results showed that there were no discernible alterations in LC in rats. The serum NE concentrations, positive neurons, mean optical density (MOD), and protein levels of TH, DBH, and CRF in model group were significantly increased compared to the control group. But XYS-treated group displayed a significantly decreased in NE levels and expressions of TH, DBH, and CRF compared to the model group. In conclusion, CIS can activate LC-NE system to release NE and then result in a significant decrease in rats. XYS treatment can effectively improve depressive-like behaviors in rats through inhibition of LC-NE neurons activity.

  4. Xiao Yao San Improves Depressive-Like Behavior in Rats through Modulation of β-Arrestin 2-Mediated Pathways in Hippocampus

    Directory of Open Access Journals (Sweden)

    Xiaoxia Zhu

    2014-01-01

    Full Text Available Xiao Yao San (XYS is a classical Chinese medicine formula that has been widely used to treat mood disorders for hundreds of years. To confirm the effect of XYS and better understand its underlying mechanism, high-performance liquid chromatography-mass spectrometry analysis-based quality control of XYS extracts and proteomics-based identification of differential proteins in the hippocampus were adopted in social isolation and chronic unpredictable mild stress- (CUMS- treated rats. The depressive-like behavior of rats induced by CUMS resembled the manifestation of human depression. The upregulated corticosterone (CORT and urocortin 2 (UCN2 levels demonstrated the existence of hypothalamic-pituitary-adrenal (HPA axis hyperactivity. XYS was effective in ameliorating the depressive-like behavior and downregulating UCN2 and CORT. XYS decreased the expression of serine/threonine-protein phosphatase 2A subunit B and increased the expression of β-arrestin 2. The expressions of brain-derived neurotrophic factor (BDNF, tyrosine receptor kinase B (TrkB, and mammalian target of rapamycin (mTOR were also elevated by XYS. In conclusion, XYS improves social isolation and CUMS-induced depressive-like behavior and ameliorates HPA hyperactivation through the downregulation of corticotrophin releasing hormone (CRH receptor 2. The upregulation of BDNF/TrkB and the phosphorylation of mTOR require β-arrestin 2 as a scaffold to regulate stress signaling.

  5. İbrahim Süreyya Bey (Yiğit ’in Hayatı ve Parlamenter Faaliyetleri İbrahim Süreyya Bey (Yiğit’s Life And Parliamentary Activities

    Directory of Open Access Journals (Sweden)

    Vicdan ÖZTÜRK

    2013-07-01

    Full Text Available In this article, life and parliamentary activities of İbrahim Süreyya Yiğit who first saw the light of day in the last period of Ottoman Empire and who witnessed decline of the Empire and struggled to save it were addressed. Having graduated from Faculty of Political Sciences, İbrahim Süreyya entered upon his career in duty position. He lived out nearly best part of his life with risky adventures. During his biennial officialism process, his relationship with the Party of Union and Progress caused him to stay in Sinop prison in repressive days of the period of II. Abdülhamit. In subsequent years after his three year imprisonment, Party of Union and Progress came into power; therefore he continued his mission with administrative duties. While İbrahim Süreyya was a provincial district governor in one of Rumelian lands, Turco- Italian War broke out; therefore he resigned from his administrative duty without any hesitation and crusaded as a volunteer. In this war, he entered into Mustafa Kemal’s service and their friendship which would last for long years began. When İbrahim Süreyya was governor of Gallipoli during First World War years, their paths with Mustafa Kemal crossed again. İbrahim Süreyya experienced trashing of war actually and he was one of the people who commenced struggle in Anatolia by taking chances with his intimate friend Mustafa Kemal during catasrtophic days in which enemies were trying to split the country. İbrahim Süreyya who took sides with Mustafa Kemal even after War of Independence and who was one of the individuals having established a state from wrecks of the war, served in the government throughout his life lasting till 1950s. Bu makalede Osmanlı Devletinin son döneminde hayata gözlerini açan ve imparatorluğun çöküşüne şahitlik ederek, onu kurtarma mücadelesi veren İbrahim Süreyya Bey (Yiğit’in hayatı ve parlamenter faaliyetleri ele alınmaktadır. Mekteb-i Mülkiye’yi bitirdikten

  6. Charakterisierung der Birnenaromatik von Österreichischem Weißburgunder (Pinot blanc hinsichtlich Typizität und Qualität

    Directory of Open Access Journals (Sweden)

    Philipp Christian

    2017-01-01

    Full Text Available Österreich ist mit einer Anbaufläche von 1.914 ha das drittgrößte Weißburgunder-produzierende Land der Welt. Diese Fläche entspricht 4,3% der österreichischen Weinbaufläche und 12,3% der Weltanbaufläche von Weißburgunder (15.493 ha. Nur in Deutschland (4.794 ha, 30,9% und in Italien (3.086 ha; 19,9% wird mehr Pinot blanc angebaut. Das Aroma von trockenem Weißburgunder ist in der Regel diskret, mit vorherrschenden Birnen- und Apfelaromen, diese kommen oft mit einem Nussaroma und einem Hauch von Blüten (Akazienblüten und Kräutern zusammen. Der Geschmack ist zart und vollmundig. Gereifte Weine zeigen oft Honig- und Mandelnoten. Ethyl-trans2-cis4-decadienoat ist bekannt als Leitaroma in frischen und verarbeiteten Birnenprodukten. Diese Verbindung wurde bis jetzt nicht in Wein beschrieben. Im Rahmen dieser Studie wurde der Gehalt an Ethyl-trans2-cis4-Decadienoat und anderen Ethyl- und Methylester der cis-trans-Isomere der Decadiensäure sowie andere mit Birne assoziierten Aromen (Isoamylacetat, Methyl-trans-Geranoat, Ethylhexanoat, Ethyloctanoat, Ethyldecanoat und Ethyldodecanoat in österreichischen Weißburgunderproben direkt in Wein mit HS-SPME-SIM-MS analysiert. Bei den Analysen konnten relevante Quantitäten an Ethyl-trans-2-cis-4-decadienoat gefunden werden. Die Konzentrationen der untersuchten Weine lagen zwischen >0,036 und 4,04 μg/L. Ein vorangegangener Test zur Feststellung des Wahrnehmungsschwellenwertes nach dem BET-3-Alternative-Forced-Choice-Verfahren ergab bei dieser Verbindung einen Wert von 2 μg/L. Somit ist der Aromastoff teilweise relevant für den Charakter der untersuchten Weine. Die Aromen wurden nach einer Konsumentenstudie ausgesucht und die sogenannte “birnenspezifische Odour Activity Value” nach zwei Verfahren berechnet. Im Zuge der sensorischen und analytischen Studien konnte festgestellt werden, dass ein Zusammenspiel einiger analysierten Aromen für den Charakter, die Qualität und die Typizit

  7. Mineralogical and compositional characteristics of Late Permian coals from an area of high lung cancer rate in Xuan Wei, Yunnan, China: Occurrence and origin of quartz and chamosite

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Shifeng; Zhao, Lei; Cao, Hongzhi; Ren, Deyi [State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology, Beijing 100083 (China); Tian, Linwei [School of Public Health, Chinese University of Hong Kong, Hong Kong SAR (China); Chou, Chen-Lin [Illinois State Geological Survey (Emeritus), 615 East Peabody Drive, Champaign, IL 61820 (United States); Zhou, Yiping; Zhang, Mingquan; Wang, Jumin; Yang, Zong [Yunnan Institute of Coal Geology Prospection, Kunming 650218 (China)

    2008-12-01

    Some townships in Xuan Wei County, Yunnan Province, have one of the highest lung cancer mortality rates in China and the epidemic disease in the area has generally been attributed to the polycyclic aromatic hydrocarbons (PAHs) released from domestic coal burning. However, the cancer-causing culprit is not settled as Tian [Tian, L., 2005. Coal Combustion Emissions and Lung Cancer in Xuan Wei, China. Ph.D. thesis, University of California, Berkeley.] found nanometer quartz in these coals, soot emissions, and lung cancer tissues. We have conducted mineralogical and geochemical studies of the coals from Xuan Wei for the purpose of shedding light on the minerals which may be related to the epidemic lung cancer. In this paper, abundances, modes of occurrence, and origins of minerals and elements in the coals from two mines in Xuan Wei have been studied using optical microscope, low-temperature ashing, X-ray diffraction analysis, scanning electron microscope equipped with energy-dispersive X-ray spectrometer, and inductively-coupled plasma mass spectrometry. The minerals in the coals are mainly composed of quartz, chamosite, kaolinite, and calcite. The particle size of quartz is rather small, mostly less than 20 {mu}m and it is of authigenic origin. Chamosite occurs mainly as cell-fillings. The occurrence of quartz and chamosite indicates that they were derived from the hydrothermal fluids. Epigenetic calcite is derived from calcic fluids. Kaolinite is derived mainly from sediment source region of Kangdian Oldland to the west of coal basin. The composition of Xuan Wei coal is high in SiO{sub 2}, Fe{sub 2}O{sub 3}, TiO{sub 2}, CaO, MnO, V, Co, Ni, Cu, and Zn. The high SiO{sub 2} content is attributed to quartz, and the Fe{sub 2}O{sub 3} content to chamosite. The high Mn and low Mg contents in the coal indicate the inputs of hydrothermal fluids. CaO occurs mainly in epigenetic calcite. Elements Ti, Co, Ni, Cu, Zn, and rare earth elements were derived from the basaltic rocks

  8. YI Kwang Su’s Love and history records of modern hospital under the japanese colonial period

    Directory of Open Access Journals (Sweden)

    Byoung Hoon LEE

    2016-12-01

    Full Text Available This article aims to evaluate and analyze the description of the modern hospital as history record, which appeared in YI Kwang Su’s novel Love. This novel has mentioned in detail western style clinic, Bukgando Catholic hospital, tuberculosis sanitarium as its main space. Modern hospitals are depicted in the novel has a great significance in historical aspect as well as in literary aspect. The most data on modern hospital is laws, statistics and newspaper archives. These materials are a great help to understand the history and status of the modern hospital. Literary description here is important materials, that specific to reconstruct the appearance of the modern hospital at that time. Literary representations infuse life into the history record. In this regard, Love has special meaning in the history of Korean modern literature. Before anything else, doctor AN Bin’s clinic as a first space of the novel vividly shows the reality of the Western style clinic and a general practitioner under the colonial period. The establishment of the hospital was based on 「Rules on private hospital」 declared by the Japanese Government General of Korea in 1919. According to this Rules, a private clinic’s founder had to submit the documents to the director of police affairs, in which all the details were written. It included name of hospital, site location and size, floor plan of a nearby building, each size of patient’s rooms, number of steps and emergency exit, bath, toilet, disinfecting room. AN Bin’s clinic was a private hospital with the requirements in the rules. The descriptions of this clinic re-created real situation of private hospitals, specifically scale of hospital, interior space, conditions of patient’s room at the time. The second modern hospital in the novel is Bukgando Catholic hospital. There is a lot more materials on medical activity and hospital of protestant churches than we thought. But we do not have a lot of information on

  9. Spatial-temporal changes of maximum and minimum temperatures in the Wei River Basin, China: Changing patterns, causes and implications

    Science.gov (United States)

    Liu, Saiyan; Huang, Shengzhi; Xie, Yangyang; Huang, Qiang; Leng, Guoyong; Hou, Beibei; Zhang, Ying; Wei, Xiu

    2018-05-01

    Due to the important role of temperature in the global climate system and energy cycles, it is important to investigate the spatial-temporal change patterns, causes and implications of annual maximum (Tmax) and minimum (Tmin) temperatures. In this study, the Cloud model were adopted to fully and accurately analyze the changing patterns of annual Tmax and Tmin from 1958 to 2008 by quantifying their mean, uniformity, and stability in the Wei River Basin (WRB), a typical arid and semi-arid region in China. Additionally, the cross wavelet analysis was applied to explore the correlations among annual Tmax and Tmin and the yearly sunspots number, Arctic Oscillation, Pacific Decadal Oscillation, and soil moisture with an aim to determine possible causes of annual Tmax and Tmin variations. Furthermore, temperature-related impacts on vegetation cover and precipitation extremes were also examined. Results indicated that: (1) the WRB is characterized by increasing trends in annual Tmax and Tmin, with a more evident increasing trend in annual Tmin, which has a higher dispersion degree and is less uniform and stable than annual Tmax; (2) the asymmetric variations of Tmax and Tmin can be generally explained by the stronger effects of solar activity (primarily), large-scale atmospheric circulation patterns, and soil moisture on annual Tmin than on annual Tmax; and (3) increasing annual Tmax and Tmin have exerted strong influences on local precipitation extremes, in terms of their duration, intensity, and frequency in the WRB. This study presents new analyses of Tmax and Tmin in the WRB, and the findings may help guide regional agricultural production and water resources management.

  10. Wei Xiong | NREL

    Science.gov (United States)

    -7965 Research Interests Production of fuels and value-added chemicals from photosynthetic , National Renewable Energy Laboratory, Biosciences Center, 2013-present Research Associate, Arizona State Physiology (2015) Illustration of a genome-based metabolic network of a lipid-producing green alga Chlorella

  11. [A survey of HIV, HBV and HCV infections in children aged 1-13 years in Yi ethnic area, Sichuan province].

    Science.gov (United States)

    Yang, Y; Zhou, Y B; Cheng, W T; Pan, X; Song, X X; Jiang, Q W

    2017-09-10

    Objective: To investigate the prevalence of HIV, HBV and HCV infections in children aged 1-13 years in Yi ethnic area in Sichuan province. Methods: A cross-sectional study was conducted in the form of field survey in four townships selected from Yi ethnic area of Sichuan during 2014-2015. Participants were children aged 1-13 years by sample size of 900 and were screened for HIV antibody, HBV surface antigen and HCV antibody, and laboratory comfirmation was conducted. The area, age, gender and ethnic group specific infection rates were compared by using Fisher's exact test, and multiple comparisons were corrected by using Bonferroni correction. Results: A total of 677 children aged 1-13 years were surveyed. The infection rates of HIV, HBV and HCV were 1.03 % (7/677, 95 %CI : 0.42 % -1.12 % ), 6.65 % (45/677, 95 %CI : 4.89 % -8.79 % ) and 0.15 % (1/677, 95 %CI : 0 % -0.82 % ), respectively. The infection rates of HIV differed among townships ( P =0.000), the infection rate was higher in township D than in township B, the difference was significant ( P HBV and HCV infections were not significant among different townships, age, gender and ethnic groups. The difference in HBV viral load between age group 5-9 years and age groups 10-13 years was not significant ( U =115.000, P =0.967). Conclusions: The burden of HIV and HBV infections in children aged 1-13 years was heavy in rural area of Yi ethnic area in Sichuan. Therefore, it is necessary to take effective measures to block the vertical transmission of HIV and HBV as well as to increase the coverage of HBV vaccination.

  12. Prevalence, awareness, medication, control, and risk factors associated with hypertension in Yi ethnic group aged 50 years and over in rural China: the Yunnan minority eye study.

    Science.gov (United States)

    Chen, Lixing; Zong, Yuan; Wei, Tao; Sheng, Xun; Shen, Wei; Li, Jun; Niu, Zhiqiang; Zhou, Hua; Zhang, Yang; Yuan, Yuansheng; Chen, Qin; Zhong, Hua

    2015-04-15

    Hypertension is an important public health issue in China, but there are few studies examining hypertension in ethnic groups in Yunnan, China. This study, Yunnan Minority Eye Study (YMES), was initially designed to determine the prevalence and impact of eye diseases, including hypertension and diabetes mellitus. As a part of YMES, the prevalence, awareness, treatment, and control of hypertension and the associated risk factors among the Yi ethnic population in rural China are reported. A population-based survey was conducted in 2012 with adult participants over 50 from rural communities in Shilin Yi Autonomous County, Yunnan Province, located in southwest China. A random cluster sampling method was used to select a representative sample. The participants' blood pressure, height, weight, and waist circumference were measured. Hypertension was defined as mean systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, and/or current use of antihypertensive medications. A total of 2208 adults were assessed. The prevalence of hypertension was 38.5%, and the age- and gender-adjusted prevalence was 37.0%. The proportion of patients who were aware of their hypertension among those diagnosed with hypertension was 24.8%. Of those aware of having hypertension, 23.6% took antihypertensive drugs. Among all hypertensive patients, only 7.2% had controlled their hypertension (population of the Yi ethnic group in China. The ratio of awareness, treatment, and control of hypertension were considerately low. Hypertension education and screening programs in rural China are recommended to improve the health status of this population.

  13. Cardioprotective Effects of QiShenYiQi Dripping Pills on Transverse Aortic Constriction-Induced Heart Failure in Mice.

    Science.gov (United States)

    Ruan, Guoran; Ren, Haojin; Zhang, Chi; Zhu, Xiaogang; Xu, Chao; Wang, Liyue

    2018-01-01

    QiShenYiQi dripping pills (QSYQ), a traditional Chinese medicine, are commonly used to treat coronary heart disease, and QSYQ was recently approved as a complementary treatment for ischemic heart failure in China. However, only few studies reported on whether QSYQ exerts a protective effect on heart failure induced by pressure overload. In this study, we explored the role of QSYQ in a mouse model of heart failure induced by transverse aortic constriction (TAC). Twenty-eight C57BL/6J mice were divided into four groups: Sham + NS group, Sham + QSYQ group, TAC + NS group, and TAC + QSYQ group. QSYQ dissolved in normal saline (NS) was administered intragastrically (3.5 mg/100 g/day) in the Sham + QSYQ and TAC + QSYQ groups. In the Sham + NS and TAC + NS groups, NS was provided every day intragastrically. Eight weeks after TAC, echocardiography, and cardiac catheterization were performed to evaluate the cardiac function, and immunofluorescent staining with anti-actinin2 antibody was performed to determine the structure of the myocardial fibers. Moreover, TUNEL staining and Masson trichrome staining were employed to assess the effects of QSYQ on cardiac apoptosis and cardiac fibrosis. Western blots and real-time polymerase chain reaction (PCR) were used to measure the expression levels of vascular endothelial growth factor (VEGF) in the heart, and immunohistochemical staining with anti-CD31 antibody was performed to explore the role of QSYQ in cardiac angiogenesis. Results showed that TAC-induced cardiac dysfunction and disrupted structure of myocardial fibers significantly improved after QSYQ treatment. Moreover, QSYQ treatment also significantly improved cardiac apoptosis and cardiac fibrosis in TAC-induced heart failure, which was accompanied by an increase in VEGF expression levels and maintenance of microvessel density in the heart. In conclusion, QSYQ exerts a protective effect on TAC-induced heart failure, which could be attributed to enhanced cardiac angiogenesis

  14. Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang.

    Science.gov (United States)

    Wang, Hang; Chan, Yi-Lin; Li, Tsung-Lin; Wu, Chang-Jer

    2012-05-01

    Cancer cachexia is characterised by the loss of body mass and directly compromises immune response and the quality of life of cancer patients. In the present study, we set out to investigate the role of Chinese herbs as anticancer medicines and/or chemotherapeutic adjuvants to increase therapeutic efficacy and/or ameliorate given side-effects in animal model. Twelve kinds of herbs were chosen from the ingredients of major Chinese herbal medicines, and their effects on the antioxidant activity were investigated. To obtain the anticancer effects of 5-fluorouracil (5-FU) when consumed with minimal side-effects, we investigated the combination effect of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang that may enhance the anticancer activity of 5-FU on subcutaneous tumour growth in C57BL/6 mice challenged with Lewis lung carcinoma cells. Qing-Shu-Yi-Qi-Tang, a multiple-component herbal extract, was shown to have high anti-oxidation activity, while S. baicalensis (Chinese skullcap) was demonstrated to have high tumour-growth inhibition activity. Thus, S. baicalensis and Qing-Shu-Yi-Qi-Tang were evaluated for their combinaton effects on the cancer-induced cachectic murine upon receiving 5-FU chemotherapy. As a result, tumour masses and losses of carcass and/or gastrocnemius muscle were found to be significantly decreased. This combination otherwise increased both Th1/Th2 ratio and NK cytotoxicity. In the mice receiving with or without 5-FU, the serum levels of monocyte chemoattractant protein-1 (MCP-1) increased by all means but otherwise decreased when the herbal combination was administrated. Additionally, the expressions of nuclear factor-kappa B (NF-κB) and muscle RING finger protein-1 (MuRF-1) decreased in the gastrocnemius muscle when the herbal combination was applied. Our results revealed that the combination of S. baicalensis and Qing-Shu-Yi-Qi-Tang is able to ameliorate cachectic symptoms and positively stimulate anti-tumour immunity while undergoing

  15. [Research on maternal health behaviors for Yi-nationality women in poor rural areas based on the theory of reasoned action].

    Science.gov (United States)

    Wu, Yuju; Hao, Gang; Sun, Shuai; Chen, Yuehui; Zhang, Rui; Liu, Qiaolan; Yang, Yang; Zhou, Huan

    2015-08-01

    To analyze the status of maternal health behaviors and it's risk factors for Yi-nationality women in poor rural areas of Sichuan province. In 2012, multi-stage stratified cluster sampling method was used to select 14 villages of two poor counties in Liangshan Yi-nationality autonomous prefecture Sichuan province. At least 10 women who have infants aged 0-12 months were selected in each simple villages, a total of 284. The structured questionnaire was developed on the basis of the theory of reasoned action. Yi-nationality female college students were trained as investigators. Research indicators included prenatal care rate, hospital delivery rate, postpartum examination rate, socio-demographic characteristics, maternal health care knowledge. χ² test was used to compare the differences of above indicators among different groups. The structural equation model were used to statistical analyze. In the 284 subject women, 51.7% (147/284) women owned more than 2 children, 41.6% (118/284) women were more than 30 years old, 87.3% (248/284) women were illiteracy. The prenatal care rate was 69.7% (197/284), the hospital delivery rate was 26.8% (76/284), and the postnatal check rate was 22.9% (65/284). The influence factors of maternal health behaviors included the number of children, age and education (χ² were 10.92, 13.24, 9.58; P values were 0.027, 0.004, 0.008, respectively).The structural equation model analysis results showed that the maternal health behaviors were directly or indirectly affected by subjective norms (β = 0.236, P < 0.001), women's cognition (β = 0.226, P = 0.020) and women's attitudes on maternal health behavior (β = 0.157, P = 0.001). Among subjective norms, women have high compliance to their husbands (β = 0.850, P < 0.001), their peers (β = 0.708, P < 0.001), and their mothers-in-law (β = 0.636, P < 0.001). There were still serious problems in maternal health behaviors for Yi-nationality women in poor rural areas. The main factors included

  16. Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics

    Directory of Open Access Journals (Sweden)

    Yung-Yi Cheng

    2018-04-01

    Full Text Available With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies. According to the National Health Insurance (NHI database in Taiwan and several publications, the three most commonly prescribed formulations for cancer patients are Xiang-Sha-Liu-Jun-Zi-Tang, Jia-Wei-Xiao-Yao-San and Bu-Zhong-Yi-Qi-Tang. The three most commonly prescribed single herbs for cancer patients are Hedyotis diffusa, Scutellaria barbata, and Astragalus membranaceus. Few studies have discussed herb–drug interactions involving these herbs from a pharmacokinetics perspective. Here, we reviewed Jia-Wei-Xiao-Yao-San, Long-Dan-Xie-Gan-Tang, Curcuma longa and milk thistle to provide information based on pharmacokinetic evidence for healthcare professionals to use in educating patients about the risks of the concomitant use of various remedies. Keywords: Traditional Chinese medicine, Chemotherapy drug, Pharmacokinetics, Herb–drug interaction

  17. Room-temperature super-extraction system (RTSES optimizes the anxiolytic- and antidepressant-like behavioural effects of traditional Xiao-Yao-San in mice

    Directory of Open Access Journals (Sweden)

    Yin Shih-Hsi

    2012-11-01

    Full Text Available Abstract Background Xiao-Yao-San (XYS is a Chinese medicinal formula for treating anxiety and depression. This study aims to evaluate the use of a room-temperature super-extraction system (RTSES to extract the major active components of XYS and enhance their psycho-pharmacological effects. Methods The neuroprotective roles of XYS/RTSES against reserpine-derived neurotoxicity were evaluated using a glial cell injury system (in vitro and a depression-like C57BL/6 J mouse model (in vivo. The anxiolytic-behavioural effects were measured by the elevated plus-maze (EPM test and the antidepressant effects were evaluated by the forced swimming test (FST and tail suspension test (TST. Glucose tolerance and insulin resistance were assayed by ELISA. The expression of 5-HT1A receptors in the prefrontal cortex was examined by western blotting. Results XYS/RTSES (300 μg/mL diminished reserpine-induced glial cell death more effectively than either XYS (300 μg/mL or fluoxetine (30 μM at 24 h (P = 0.0481 and P = 0.054, respectively. Oral administration of XYS/RTSES (500 mg/kg/day for 4 consecutive weeks significantly elevated the ratios of entries (open arms/closed arms; P = 0.0177 and shuttle activity (P = 0.00149 on the EPM test, and reduced the immobility time by 90% on the TST (P = 0.00000538 and FST (P = 0.0000053839. XYS/RTSES also improved the regulation of blood glucose (P = 0.0305 and increased the insulin sensitivity (P = 0.0093. The Western blot results indicated that the activation of cerebral 5-HT1A receptors may be involved in the mechanisms of XYS/RTSES actions. Conclusion The RTSES could provide a novel method for extracting effective anxiolytic- and antidepressant-like substances. XYS/RTSES improved the regulation of blood glucose and increased the insulin sensitivity in reserpine-induced anxiety and depression. Neuroprotection of glial cells and activation of cerebral 5-HT1A receptors were also involved.

  18. A study on the traditionalism of “trot” – Focused on Yi Nanyǒng’s “Tears of Mokp’o”

    Directory of Open Access Journals (Sweden)

    Yujeong Chang

    2016-06-01

    Full Text Available In this paper, I explore the significance of Yi Nanyǒng’s contribution to the history of Korean popular music through her song “Tears of Mokp’o.” Using the data I gathered from surveys and interviews as well as a formal analysis of the song, I expounded on the perceptional changes of “Tears of Mokp’o” from a hybrid colonial song to an ethnic, national song. For this purpose, I structured this paper as follows: In the second section, I looked into the meaning and changes in trot spanning different periods, and investigated the current public sentiment toward trot. In the third section, I examined Yi Nan-yǒng’s life and her songs, as well as the public opinion of her works via survey analysis. Finally, I expounded on the traditionalism found in “Tears of Mokp’o.” Through these materials, we could delineate how trot shifted from a foreign song to a traditional one.

  19. The role and significance of Luo Zhiyuan's Shu yi hui bian in the history of plague in Lingnan (south of the five ridges).

    Science.gov (United States)

    Li, H; Lai, W

    1999-04-01

    Being the earliest monograph on plague in China, Luo Zhiyuan's Shu yi hui bian, not included in the National Catalogue of TCM Books, include the following contents: personal idea on the etiology of plague; Luo's friend Wu Xuanchang' unpublished Shu yu zhi fa on the treatment and manifestations of plague; Luo's specific recipe for plague based on medified Wang Qingren's Jie du huo xue decoction based on Wang Qingrens yi lin gai cuo; therapy for critical cases; many therapies applied on Lingnan, including experimental recipes, external therapy, preventive methods, and preventing recurrence methods; Luo's special administrating methods, including persisting day-and-night method, immediate persisting method, single-dose persisting method, and double-dose persisting method. He also gave several cured case records. His book, featuring unique idea with good effect, was repeatedly printed and extensively distributed, exerting influence, more or less, on the plague monographs of later ages, and occupying important position in the history of plague on Lingnan and the whole country as well. His idea of "that poisons and static blood" in pathogenesis and therapeutic principle of antitoxicity and activating blood is coincided with the results of present day clinical and laboratory studies. His administration of medicines is heuristic to the therapy of critical cases with Chinese medicaments and to the recognition of pathogenesis, etiology, and treatment of modern plague as well as other diseases of similar etiology and pathognesis and is worth of further study.

  20. Calcium-sensing receptor gene polymorphism (rs7652589) is associated with calcium nephrolithiasis in the population of Yi nationality in Southwestern China.

    Science.gov (United States)

    Li, Hao; Zhang, Jianhua; Long, Jiang; Shi, Jiarun; Luo, Yuhui

    2018-04-16

    The calcium-sensing receptor (CaSR) gene plays an important role in regulating the Ca 2+ balance and reducing the risk for calcium stones. In this study, we evaluated the association of CaSR polymorphisms with calcium nephrolithiasis in the population of Yi nationality in Southwestern China. Biochemical variables were evaluated in 624 calcium nephrolithiasis patients and 470 age-matched healthy controls without a history of nephrolithiasis. CaSR polymorphisms rs7652589, rs1501899, rs1801725 (Ala986Ser), rs1042636 (Arg990Gly) and rs1801726 (Gln1011Glu) were investigated between the calcium nephrolithiasis patients and healthy controls, using direct sequencing. Compared with the healthy controls, serum creatinine and 24-hour urine calcium levels were significantly higher in calcium nephrolithiasis patients. Among these five polymorphisms, the genotypic and allelic frequency distributions of rs7652589 SNP was significantly associated with the risk of calcium nephrolithiasis. However, there were no genotypic or allelic distribution differences for rs1501899, rs1801725, rs1042636, and rs1801726 polymorphisms between calcium nephrolithiasis patients and healthy controls. Moreover, the association between rs7652589 SNP genotypes and the biochemical variables was not found. Our study showed that CaSR rs7652589 polymorphism had a significant effect on the risk of developing calcium nephrolithiasis in the population of Yi nationality in Southwestern China. © 2018 John Wiley & Sons Ltd/University College London.

  1. VALIDASI MODIFIKASI METODE WEIßHAAR UNTUK ANALISIS 3-MCPD ESTER DALAM MINYAK GORENG SAWIT [Validation of Modified Weißhaar’s Method for 3-MCPD Esters Analysis in Palm Oil

    OpenAIRE

    Tanti Lanovia1,2)*; Nuri Andarwulan1,3); Purwiyatno Hariyadi1,3)

    2014-01-01

    The 3-monochloropropane-1,2-diol (3-MCPD) and 3-MCPD esters were found in any type of refined vegetable oil -mostly produced during the refining process- and recognized as emerging food contaminants. Several analytical methods have been developed and one of which was a Weißhaar's method. The study aims to validate the modified Weißhaar's method for analysis of 3-MCPD and 3-MCPD esters in refined palm oil. Ion fragments were used for identification and quantification of 3-MCPD and 3-MCPD-d5. 3...

  2. An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m

    International Nuclear Information System (INIS)

    Giani, Tania Santos; Paoli, Severo de; Brandao-Neto, Jose; Medeiros, Aldo da Cunha; Presta, Giuseppe Antonio; Maiworm, Adalgisa Ieda; Santos Filho, Sebastiao David; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mario

    2007-01-01

    Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m ( 99m Tc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99m Tc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and 99m Tc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated. Buzhong extract at the highest concentrations used altered significantly (p 99 mTc. (author)

  3. Assessment of effects of a formula used in the traditional Chinese medicine (Buzhong Yi Qi Wan on the morphologic and osmotic fragility of red blood cells

    Directory of Open Access Journals (Sweden)

    Tania S. Giani

    Full Text Available Buzhong Yi Qi Wan (BYQW is a combination of some medicinal herbs widely used in traditional Chinese medicine to treat blood, spleen and stomach disorders. Morphometric analysis and osmotic fragility assay have been used to evaluate changes on membrane integrity of red blood cells. The aim of this work was to evaluate the effect of an aqueous BYQW extract on the morphology and osmotic fragility of red blood cells. Blood samples were treated with BYQW extract, quantitative/qualitative morphological analysis and osmotic fragility assay were carried out against control groups treated with saline. The data obtained indicated no modification on morphology but osmotic fragility assay suggested a significant (p<0.05 increasing of hemolysis in red blood cells isolated from blood treated with aqueous BYQW extract. In conclusion, the aqueous BYQW extract could affect the membrane integrity decreasing the osmotic resistance but without altering the shape of red blood cells.

  4. ADHERENCE AND PA THOGENICITY ASSA Y OF VIBRIO HARVE YI IN TIGER SHRIMP (PENAEUS MONODON LARVAE FOR SC REENING BIOCONTROL AGE NT

    Directory of Open Access Journals (Sweden)

    YUSMINAH H ALA

    2002-01-01

    Full Text Available Rifampicin-resistant marker w as empl oyed as a repor ter t o detect the ad here nce and colonization of V. harve yi in s hrimp larvae. Vibri o h arve yi P1B and YA3 2. 2 were isolated f rom dead s hrimp la rv ae i n Besuki, Norther n C oast of East Jav a, while V. harveyi HB3, was isolated from pris tine sea water in Pacita n, S outhe rn Coast of E ast Ja va . Vi brio metsc hnikovii used a s bioc ontr ol a gent was i solated fr om healthy shrimp larvae in Serang, We st Java. Spontane ous mutation was c onducted to generate V. harveyi P1B, YA32.2 and HB3 resistant to rifampi cin. These mutants exhibit ed similar survival ability to t heir parent al (wild type strai ns. Signifi cant larval mortalit y was o bserv ed i n s hrimp l arv ae i noculated with YA32.2 than that of larvae ino culated with P1B. Larvae inoculated with H B 3 showed the lo w est mortality. Bacterial cell c ount of Vi brio Rf* in dead larvae w ere 103-104 cells/larvae. Isolates of Vi brio metschnikovii Z an d M as biocontrol candid ates effectively r educed the growth a nd a dherence ability of YA32.2 t o shrimp larvae. Larval mort ality in rearing water inoculat ed simultaneousl y w ith YA32.2 and V. metschnikovii was lower than the one inoculated with YA32.2 alone. Therefore, Vibrio metschnikovii Z or M could be develope d as an effective pro biotic or biocontrol agent for V. harvey i in shrimp hatcheri es.

  5. Rezension von: Gabriele Dietze: Weiße Frauen in Bewegung. Genealogien und Konkurrenzen von Race- und Genderpolitiken. Bielefeld: transcript Verlag 2013.

    Directory of Open Access Journals (Sweden)

    Philipp Dorestal

    2014-03-01

    Full Text Available Gabriele Dietze zeichnet das Verhältnis der Kategorien Race und Gender innerhalb der US-amerikanischen Geschichte von der Mitte des 19. Jahrhunderts bis zur Präsidentschaftswahl von Barack Obama nach. Dabei demonstriert sie anhand von zentralen Figuren der weißen Frauenbewegung deren ambivalente Positionen, die oftmals für progressive Inhalte wie das Eintreten für Frauenrechte stehen, gleichzeitig aber dann Anliegen von African Americans nicht artikulieren oder gar zum Schweigen bringen. Ebenso zeigt Dietze mithilfe von Texten einiger schwarzer Autor_innen sowie anhand berühmter Gerichtsprozesse, dass schwarze Emanzipation nicht notwendigerweise mit feministischen Positionen einhergehen musste, sondern sich vielmehr eine Konkurrenzsituation zwischen Race und Gender entspann.

  6. Factors affecting domestic water consumption in rural households upon access to improved water supply: insights from the Wei River Basin, China.

    Science.gov (United States)

    Fan, Liangxin; Liu, Guobin; Wang, Fei; Geissen, Violette; Ritsema, Coen J

    2013-01-01

    Comprehensively understanding water consumption behavior is necessary to design efficient and effective water use strategies. Despite global efforts to identify the factors that affect domestic water consumption, those related to domestic water use in rural regions have not been sufficiently studied, particularly in villages that have gained access to improved water supply. To address this gap, we investigated 247 households in eight villages in the Wei River Basin where three types of improved water supply systems are implemented. Results show that domestic water consumption in liters per capita per day was significantly correlated with water supply pattern and vegetable garden area, and significantly negatively correlated with family size and age of household head. Traditional hygiene habits, use of water appliances, and preference for vegetable gardening remain dominant behaviors in the villages with access to improved water supply. Future studies on rural domestic water consumption should pay more attention to user lifestyles (water appliance usage habits, outdoor water use) and cultural backgrounds (age, education).

  7. [Applying the Methodology and Practice of Microhistory: The Diary of a Confucian Doctor, Yi Mun-gǒn (1495-1567)].

    Science.gov (United States)

    Shin, Dongwon

    2015-08-01

    Since microhistory's approach to the past is based on an understanding of and a sympathy for the concrete details of human lives, its area of interests overlaps with the history of medicine and medical humanities, which examine illness and health. If we put a specific region and society in a specific period under a microscope and increase the magnifying power, we can understand the numerous network connections among the body, illness management, and medicine and how multilayered were the knowledge and power applied to them. And this approach of using microhistory to illuminate medical history can be more effective than any other historical approach. This article focuses on Yi Mun-gǒn's extensive volumes of Mukchaeilgi (Mukchae's diary) in approaching medical history from the perspective of microhistory. Simply defined, this work is a Confucian scholar-doctor's diary. Its author, Yi Mun-gǒn, played the role of a Confucian doctor, although not professionally, during his 23-year exile, after serving in a high governmental office on the senior grade of the third court rank. Thanks to this extensive and detailed diary, we can now get adetailed andthorough picture of his medical practice in the Sǒngju region, 270 kilometers southeast of Seoul, where he was exiled. This article aims to understand the state of medical practice in the Sǒngju region in the 16thcentury through the"zoom-in" method adopted by microhistory. In particular, I will focus on the following three aspects:1) Yi Mun-gǒn's motivation for and method of medical study, 2)the character of Yi Mun-gǒn'spatient treatment as hwarin (the act of life-saving), and 3) the plural existence of various illness management methods, including pyǒngjǒm (divination of illness), sutra-chanting, exorcism, and ch'oje (ritual toward Heaven). All three aspects are closely related to Confucianism. First, Yi Mun-gǒn decided to acquire professional-level medical knowledge in order to practice the Confucian virtue of filial

  8. Kuva-yi Milliye Müzesindeki Sırp Kralı II. Stefan Uroš Milutin (1282-1321 Dönemine Ait Gümüş Sikke A Silver Coin of Serbian King Stephan Uros II Milutin (1282-1321 from Kuva-yi Milliye Museum

    Directory of Open Access Journals (Sweden)

    Ceren ÜNAL

    2012-12-01

    Full Text Available Museum of Kuva-yi Milliye in Balıkesir which is located in thenorth-western part of Turkey was established in 1996. The Museum ofKuva-yi Milliye has approximately 2.500 coins from different culturesand ages. As a result of some research, done between 2011-2012August, one rare silver coin which dated back to Medieval era of Serbiawas detected.There is a silver dinar of Serbian king Stephen Uroš II Milutin(1282-1321 in Kuva-yi Milliye Museum which might have come toAnatolia with the international trade route. Serbian silver dinar wasfound together with a group of Venetian silver coins and it was wronglyclassified to Byzantine Empire which was an effective culture in thatera. Most probably, Serbian silver coin which was dated back to the endof the 13th century, might have come to the Anatolia with a trade ofVenetia. The coin which is protected in the Museum is the reflection of arich culture of Anatolia which is the center of overseas trade betweenEast and West.When Byzantine Empire began to lose its power in 12th century,the idea of independence between Balkan communities developed.Serbian Kingdom which was established in 12th century was gettingstronger gradually and its borders were extended. Therefore, SerbianKingdom reached a balance situation between the West and ByzantineEmpire. As the Serbian Kingdom, was located on the overland journeybetween the West and the East, it had effective relations with itswestern alliances. Because of its strategical location, Byzantine Empirehad to have good relations with them.This rare silver dinar most probably came to Anatolia with theVenetian merchants who were dominant in the sea trade in that era. Itwill be presented with the help of the historical background of theBalkans and Serbia. Türkiye’nin kuzeybatısında, Balıkesir ilinde yer alan Kuva-yi Milliye Müzesi 1996 yılında kurulmuştur. Kuva-yi Milliye Müzesi’nde yaklaşık olarak 2.500 adet farklı kültürler ve dönemlere ait sikke

  9. An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan alters the labeling of blood constituents with technetium-99m

    Directory of Open Access Journals (Sweden)

    Tania Santos Giani

    2007-09-01

    Full Text Available Buzhong Yi Qi Wan (Buzhong is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m (99mTc are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99mTc. Heparinized blood (Wistar rats was incubated in vitro with different Buzhong extract concentrations and 99mTc-labeling was performed. Plasma (P and blood cells (BC were separated and soluble (SF-P, SF-BC and insoluble (IF-P, IF-BC fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI was calculated. Buzhong extract at the highest concentrations used altered significantly (pBuzhong Yi Qi Wan (Buzhong é uma fórmula utilizada na Medicina Tradicional Chinesa para tratamento de distúrbios nos sistemas digestório e circulatório. Constituintes sangüíneos marcados com tecnécio-99m (99mTc são usados na medicina nuclear. O objetivo deste estudo foi investigar os efeitos do extrato de Buzhong na marcação de constituintes sangüíneos com 99mTc. Amostras de sangue de ratos Wistar foram incubadas com diferentes concentrações do extrato de Buzhong e a marcação de constituintes sangüíneos com 99mTc foi realizado. Plasma e células sangüíneas foram separados, frações solúveis e insolúveis do plasma e das células sangüíneas foram isoladas. A radioatividade nos constituintes sangüíneos foi contada e as porcentagens de radioatividade incorporada (%ATI, determinada. Extrato de Buzhong nas maiores concentrações utilizadas altera significativamente (p<0.05 a %ATI nos constituintes sangüíneos. Substâncias presentes no extrato de Buzhong poderiam alterar a membrana celular e/ou gerar radicais livres, que têm propriedades oxidantes, modificando a marcação dos constituintes sangüíneos com

  10. Farmer and retailer knowledge and awareness of the risks from pesticide use: A case study in the Wei River catchment, China

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xiaomei, E-mail: xiaomei.yang@wur.nl [Soil Physics and Land Management, Wageningen University, P.O. Box 47, 6700AA Wageningen (Netherlands); State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, 712100 Yangling (China); Wang, Fei [State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, 712100 Yangling (China); Institute of Soil and Water Conservation, Northwest A and F University, 712100 Yangling (China); Meng, Lei [Baoji University of Arts and Sciences, 712300 Baoji, Shaanxi (China); Zhang, Wenshuai [State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, 712100 Yangling (China); Fan, Liangxin [School of Surveying and Land Information Engineering, Henan Polytechnic University, 454003 Jiaozuo, Henan Province (China); Geissen, Violette [Soil Physics and Land Management, Wageningen University, P.O. Box 47, 6700AA Wageningen (Netherlands); Institute of Crop Science and Resources Conservation (INRES), University of Bonn, 53115 Bonn (Germany); Ritsema, Coen J. [Soil Physics and Land Management, Wageningen University, P.O. Box 47, 6700AA Wageningen (Netherlands)

    2014-11-01

    Monitoring the educational level of farmers and retailers on pesticide use would be useful to assess the appropriateness of information for reducing or/and avoiding the risks from pesticides in rural regions. The levels of knowledge and awareness of the dangers to the environment and human health were investigated by questionnaires for farmers (209) and retailers (20) in two rural regions (Qianyang County (S1) and Chencang County (S2)) of the Wei River catchment in China where the modes of farming and the state of erosion are very different. The results showed that farmers learned the use and dangers of pesticides mainly by oral communication (p < 0.01). Protective measures were inadequate; 65% (S1) and 55% (S2) of farmers never used any protective measures during spraying (p < 0.05). Washing hands (> 70%) was the most common mode of personal hygiene, relative to wearing masks, showering, and changing clothes, but no significant differences were observed between the selected regions. Most pesticide wastes were dumped directly onto the land or into water, suggesting that educational measures should be taken to address the potential risks from the residues in the wastes. Over 85% of farmers (S1 and S2) claimed to use illegal pesticides, but the reasons for their use varied (p < 0.01). Retailers were well-informed and highly conscious of their responsibility for the safe use of pesticides, especially in S2 (p < 0.01). A canonical correspondence analysis indicated that educational level and age differed between the two regions and contributed greatly to the risks from pesticide use (p < 0.01). Educational programmes targeted to age groups, proper disposal of pesticide waste, and sufficient supervision from authorities should consequently be considered for improving the levels of knowledge and awareness of the dangers of pesticides to human health and environmental pollution in the Wei River catchment, China. - Highlights: • The status of income and expenditure on

  11. Farmer and retailer knowledge and awareness of the risks from pesticide use: A case study in the Wei River catchment, China

    International Nuclear Information System (INIS)

    Yang, Xiaomei; Wang, Fei; Meng, Lei; Zhang, Wenshuai; Fan, Liangxin; Geissen, Violette; Ritsema, Coen J.

    2014-01-01

    Monitoring the educational level of farmers and retailers on pesticide use would be useful to assess the appropriateness of information for reducing or/and avoiding the risks from pesticides in rural regions. The levels of knowledge and awareness of the dangers to the environment and human health were investigated by questionnaires for farmers (209) and retailers (20) in two rural regions (Qianyang County (S1) and Chencang County (S2)) of the Wei River catchment in China where the modes of farming and the state of erosion are very different. The results showed that farmers learned the use and dangers of pesticides mainly by oral communication (p < 0.01). Protective measures were inadequate; 65% (S1) and 55% (S2) of farmers never used any protective measures during spraying (p < 0.05). Washing hands (> 70%) was the most common mode of personal hygiene, relative to wearing masks, showering, and changing clothes, but no significant differences were observed between the selected regions. Most pesticide wastes were dumped directly onto the land or into water, suggesting that educational measures should be taken to address the potential risks from the residues in the wastes. Over 85% of farmers (S1 and S2) claimed to use illegal pesticides, but the reasons for their use varied (p < 0.01). Retailers were well-informed and highly conscious of their responsibility for the safe use of pesticides, especially in S2 (p < 0.01). A canonical correspondence analysis indicated that educational level and age differed between the two regions and contributed greatly to the risks from pesticide use (p < 0.01). Educational programmes targeted to age groups, proper disposal of pesticide waste, and sufficient supervision from authorities should consequently be considered for improving the levels of knowledge and awareness of the dangers of pesticides to human health and environmental pollution in the Wei River catchment, China. - Highlights: • The status of income and expenditure on

  12. Inter- and intra-annual variability of fluvial sediment transport in the proglacial river Riffler Bach (Weißseeferner, Ötztal Alps, Tyrol)

    Science.gov (United States)

    Baewert, Henning; Weber, Martin; Morche, David

    2015-04-01

    The hydrology of a proglacial river is strongly affected by glacier melting. Due to glacier retreat the effects of snow melt and rain storms will become more important in future decades. Additionally, the development of periglacial landscapes will play a more important role in the hydrology of proglacial rivers. The importance of paraglacial sediment sources in sediment budgets of glacier forefields is increasing, while the role of glacial erosion is declining. In two consecutive ablation seasons the fluvial sediment transport of the river Riffler Bach in the Kaunertal (Tyrol/Austria) was quantified. The catchment area of this station is 20 km² with an altitudinal range from 1929 m to 3518 m above msl. The "Weißseeferner" glacier (2.34 km² in 2012) is the greatest of the remaining glaciers. An automatic water sampler (AWS 2002) and a probe for water level were installed were installed at the outlet of the catchment. In order to calculate annual stage-discharge-relations, discharge (Q) was repeatedly measured with current meters. Concurrent to the discharge measurements bed load was collected using a portable Helley-Smith sampler. Bed load (BL) samples were weighted and sieved in the laboratory to gain annual bed load rating curves and grain size distributions. In 2012, 154 water samples were sampled during 7 periods and subsequently filtered to quantify suspended sediment concentrations (SSC). A Q-SSC-relation was calculated for every period due to the high variability in suspended sediment transport. In addition, the grain size distribution of the filtered material was determined by laser diffraction analysis. In 2013, the same procedure was performed for 232 water samples which were collected during 9 periods. Meteorological data were logged at the climate station "Weißsee", which is located in the centre of the study area. First results show a high variability of discharge and solid sediment transport both at the inter-annual as well as at the intra

  13. Yi Qi Qing Re Gao-containing serum inhibits lipopolysaccharide-induced rat mesangial cell proliferation by suppressing the Wnt pathway and TGF-β1 expression.

    Science.gov (United States)

    Yang, Liping; Sun, Xueyan; Zhan, Yongli; Liu, Huijie; Wen, Yumin; Mao, Huimin; Dong, X I; Li, Ping

    2016-04-01

    The aim of the present study was to investigate the effect of Yi Qi Qing Re Gao-containing serum (YQ-S) on rat mesangial cell (MC) proliferation and to investigate the underlying mechanism. MCs were divided into the control, lipopolysaccharide (LPS)-stimulated, YQ-S and fosinopril-containing serum (For-S) groups, and cultured for 48 h. An MTT assay was used to evaluate the proliferation of MCs. In addition, reverse transcription-quantitative polymerase chain reaction and western blot analysis were conducted to detect the expression levels of Wnt4, β-catenin and transforming growth factor (TGF)-β1 in MCs. The results indicated that YQ-S inhibited LPS-induced MC proliferation. The Wnt4 and TGF-β1 mRNA expression levels were reduced in the YQ-S group (P<0.01 or P<0.05). Furthermore, the Wnt4, β-catenin and TGF-β1 protein expression levels were suppressed in the YQ-S group (P<0.01 or P<0.05). Therefore, YQ-S appears to inhibit MC proliferation, and its mechanism may involve the inhibition of the Wnt signaling pathway and downregulation of TGF-β1 expression.

  14. An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m

    Energy Technology Data Exchange (ETDEWEB)

    Giani, Tania Santos; Paoli, Severo de; Brandao-Neto, Jose; Medeiros, Aldo da Cunha [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Centro de Ciencias da Saude. Programa de Pos-graduacao em Ciencias da Saude]. E-mail: tgiani@gmail.com; Presta, Giuseppe Antonio; Maiworm, Adalgisa Ieda; Santos Filho, Sebastiao David; Fonseca, Adenilson de Souza da [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Inst. de Biologia Roberto Alcantara Gomes. Lab. de Radiofarmacia Experimental; Bernardo-Filho, Mario [Instituto Nacional de Cancer (INCa), Rio de Janeiro, RJ (Brazil). Centro de Pesquisa Basica

    2007-09-15

    Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m ({sup 99m}Tc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with {sup 99m}Tc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and {sup 99m}Tc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated. Buzhong extract at the highest concentrations used altered significantly (p<0.05) the %ATI in blood constituents. Substances present in the Buzhong extract could alter the cellular membrane and/or generation of free radicals that have oxidant properties modifying the labeling of blood constituents with {sup 99}mTc. (author)

  15. The Contribution of Different Components in QiShenYiQi Pills® to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury

    Directory of Open Access Journals (Sweden)

    Yuan-Chen Cui

    2018-04-01

    Full Text Available Ischemic heart diseases remain a challenge for clinicians. QiShenYiQi pills® (QSYQ has been reported to be curative during coronary heart diseases with modulation of energy metabolism as one of the underlying mechanisms. In this study, we detected the effect of QSYQ and its components on rat myocardial structure, mitochondrial respiratory chain complexes activity and energy metabolism, and heart function after 30 min of cardiac ischemia, with focusing on the contribution of each component to its potential to regulate energy metabolism. Results showed that treatment with QSYQ and all its five components protected myocardial structure from damage by ischemia. QSYQ also attenuated release of myocardial cTnI, and restored the production of ATP after cardiac ischemia. AS-IV and Rb1, but not Rg1, R1, and DLA, had similar effect as QSYQ in regulation of energy metabolism. These results indicate that QSYQ may prevent ischemia-induced cardiac injury via regulation of energy metabolism, to which each of its components contributes differently.

  16. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  17. Effects of Xiaochuan Yi Hao on plasma TXB2 and 6-K-PGF1α levels in guinea pig with asthma

    International Nuclear Information System (INIS)

    Chen Jinyan; Cheng Zhixi; Li Zhiqiang

    2002-01-01

    Objective: Xiaochuan Yi Hao (XYH) is a clinically proved effective recipe for treatment of asthma. According to current understanding of the disease mechanism of bronchial asthma the plasma levels as thromboxane B 2 (TXB 2 ) and 6-keto-prostaglandin F 1α (6-K-PGF 1α ) were studied in guinea to elucidate the pharmacological action of XYH recipe. Methods: Asthma was induced in guinea pigs after immunization with abdominal injection of 10% egg albumin. The latent period of asthma paroxysm was observed after sensitized guinea pigs had inhaled the albumin aerosol. TXB 2 and 6-K-PGF 1α levels in plasma were detected by radioimmunoassay (RIA). Results: Plasma TXB 2 and 6-K-PGF 1α levels were 197.53 +- 87.56 pg/ml and 29.08 +- 9.17 pg/ml respectively in the asthma model group. XYH recipe was able to restore the TXB 2 and 6-K-PGF 1α levels towards normal to 123.40 +- 59.78 pg/ml and 41.73 +- 14.81 pg/ml. The effect of XYH recipe was shown to be dose related. Conclusion: XYH might be effective in treatment-of bronchial asthma through restoring the balance between TXB 2 and 6-K-PGF 1α

  18. Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

    Directory of Open Access Journals (Sweden)

    Jinqiu Yin

    2017-11-01

    Full Text Available As a leading cause of respiratory disease, influenza A virus (IAV presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH is a famous traditional Chinese medicine (TCM used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2 (Nrf2 and nuclear factor kappa B (NF-κB, which subsequently upregulated heme oxygenase-1 (HO-1 expression. Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions, CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway.

  19. Identification of the chemical constituents of Chinese medicine Yi-Xin-Shu capsule by molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation.

    Science.gov (United States)

    Wang, Hong-ping; Chen, Chang; Liu, Yan; Yang, Hong-Jun; Wu, Hong-Wei; Xiao, Hong-Bin

    2015-11-01

    The incomplete identification of the chemical components of traditional Chinese medicinal formula has been one of the bottlenecks in the modernization of traditional Chinese medicine. Tandem mass spectrometry has been widely used for the identification of chemical substances. Current automatic tandem mass spectrometry acquisition, where precursor ions were selected according to their signal intensity, encounters a drawback in chemical substances identification when samples contain many overlapping signals. Compounds in minor or trace amounts could not be identified because most tandem mass spectrometry information was lost. Herein, a molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation method for complex Chinese medicine chemical constituent analysis was developed. The precursor ions were selected according to their two-dimensional characteristics of retention times and mass-to-charge ratio ranges from herbal compounds, so that all precursor ions from herbal compounds were included and more minor chemical constituents in Chinese medicine were identified. Compared to the conventional automatic tandem mass spectrometry setups, the approach is novel and can overcome the drawback for chemical substances identification. As an example, 276 compounds from the Chinese Medicine of Yi-Xin-Shu capsule were identified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Variations in annual water-energy balance and their correlations with vegetation and soil moisture dynamics: A case study in the Wei River Basin, China

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Shengzhi; Huang, Qiang; Leng, Guoyong; Zhao, Menglong; Meng, Erhao

    2017-03-01

    It is of importance to investigate watershed water-energy balance variations and to explore their correlations with vegetation and soil moisture dynamics, which helps better understand the interplays between underlying surface dynamics and the terrestrial water cycle. The heuristic segmentation method was adopted to identify change points in the parameter to series in Fu's equation belonging to the Budyko framework in the Wei River Basin (WRB) and its sub-basins aiming to examine the validity of stationary assumptions. Additionally, the cross wavelet analysis was applied to explore the correlations between vegetation and soil moisture dynamics and to variations. Results indicated that (1) the omega variations in the WRB are significant, with some change points identified except for the sub-basin above Zhangjiashan, implying that the stationarity of omega series in the WRB is invalid except for the sub-basin above Zhangjiashan; (2) the correlations between soil moisture series and to series are weaker than those between Normalized Difference Vegetation Index (NDVI) series and omega series; (3) vegetation dynamics show significantly negative correlations with omega variations in 1983-2003 with a 4-8 year signal in the whole WRB, and both vegetation and soil moisture dynamics exert strong impacts on the parameter omega changes. This study helps understanding the interactions between underlying land surface dynamics and watershed water-energy balance. (C) 2017 Elsevier B.V. All rights reserved.

  1. The Dual Antimelanogenic and Antioxidant Activities of the Essential Oil Extracted from the Leaves of Acorus macrospadiceus (Yamamoto F. N. Wei et Y. K. Li

    Directory of Open Access Journals (Sweden)

    Huey-Chun Huang

    2012-01-01

    Full Text Available The antimelanogenic and antioxidant activities of the essential oil extracted from the leaves of Acorus macrospadiceus (Yamamoto F. N. Wei et Y. K. Li have never been explored. The essential oil effectively inhibited mushroom tyrosinase activity (EC50 = 1.57 mg/mL and B16F10 tyrosinase activity (IC50 = 1.01 mg/mL, decreased the melanin content (EC50 = 1.04 mg/mL, and depleted the cellular level of the reactive oxygen species (ROS (EC50 = 1.87 mg/mL. The essential oil effectively scavenged 2,2-diphenyl-1-picryl-hydrazyl (DPPH (EC50 = 0.121 mg/mL and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid ABTS+ radicals (EC50 = 0.122 mg/mL. It also exhibited an apparent reducing power (EC50 = 0.021 mg/mL and metal-ion chelating activity (EC50 = 0.029 mg/mL. The chemical constituents of the essential oil are ethers (55.73%, ketones (19.57%, monoterpenes (7.82%, alcohols (3.85%, esters (3.77%, sesquiterpenes (3.72%, and aromatic compounds (2.85%. The results confirm that A. macrospadiceus essential oil is a natural antioxidant and inhibitor of melanogenesis.

  2. The Dual Antimelanogenic and Antioxidant Activities of the Essential Oil Extracted from the Leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li

    Science.gov (United States)

    Huang, Huey-Chun; Wang, Hsiao-Fen; Yih, Kuang-Hway; Chang, Long-Zen; Chang, Tsong-Min

    2012-01-01

    The antimelanogenic and antioxidant activities of the essential oil extracted from the leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li have never been explored. The essential oil effectively inhibited mushroom tyrosinase activity (EC50 = 1.57 mg/mL) and B16F10 tyrosinase activity (IC50 = 1.01 mg/mL), decreased the melanin content (EC50 = 1.04 mg/mL), and depleted the cellular level of the reactive oxygen species (ROS) (EC50 = 1.87 mg/mL). The essential oil effectively scavenged 2,2-diphenyl-1-picryl-hydrazyl (DPPH) (EC50 = 0.121 mg/mL) and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) ABTS+ radicals (EC50 = 0.122 mg/mL). It also exhibited an apparent reducing power (EC50 = 0.021 mg/mL) and metal-ion chelating activity (EC50 = 0.029 mg/mL). The chemical constituents of the essential oil are ethers (55.73%), ketones (19.57%), monoterpenes (7.82%), alcohols (3.85%), esters (3.77%), sesquiterpenes (3.72%), and aromatic compounds (2.85%). The results confirm that A. macrospadiceus essential oil is a natural antioxidant and inhibitor of melanogenesis. PMID:23304214

  3. [Effect of electro-acupuncture on metabolites in the cerebral cortex of ulcerative colitis rats based on Pi/Wei-brain related theory].

    Science.gov (United States)

    Yang, Yang; Zhao, Ji-lan; Hou, Tian-shu; Han, Xiao-xia; Zhao, Zheng-yu; Peng, Xiao-hua; Wu, Qiao-Feng

    2014-10-01

    To study the effect of electro-acupuncture (EA) at points along Foot Yangming Channel on metabolite of ulcerative colitis (UC) rats' cerebral cortex and to identify key metabolites by referring to Pi/Wei-brain related theory in Chinese medicine (CM). The UC rat model was set up by dextran sulfate sodium (DSS) method. Male SD rats were randomly divided into the model group and the EA group, 13 in each group. Another 13 rats were recruited as the blank control group. Rats in the blank control group and the model group received no EA. EA was performed at Zusanli (ST36), Shangjuxu (ST37), and Tianshu (ST25) for 5 days by using disperse-dense wave. Then all rats were sacrificed. Their recto-colon and the ileocecal junction were pathomorphologically observed by light microscope and transmission electron microscope (TEM). Cerebral cortexes were extracted. Water-soluble and lipid-soluble brain tissue metabolites were respectively extracted for metabolic research using 1H nuclear magnetic resonance (1H-NMR). EA could obviously improve the general condition of UC model rats, decrease the value of DAI, reduce the infiltration of inflammatory cells in the intestinal tract, stabilize structures such as mitochondria, endoplasmic reticulum and so on (P theory.

  4. Factors affecting domestic water consumption in rural households upon access to improved water supply: insights from the Wei River Basin, China.

    Directory of Open Access Journals (Sweden)

    Liangxin Fan

    Full Text Available Comprehensively understanding water consumption behavior is necessary to design efficient and effective water use strategies. Despite global efforts to identify the factors that affect domestic water consumption, those related to domestic water use in rural regions have not been sufficiently studied, particularly in villages that have gained access to improved water supply. To address this gap, we investigated 247 households in eight villages in the Wei River Basin where three types of improved water supply systems are implemented. Results show that domestic water consumption in liters per capita per day was significantly correlated with water supply pattern and vegetable garden area, and significantly negatively correlated with family size and age of household head. Traditional hygiene habits, use of water appliances, and preference for vegetable gardening remain dominant behaviors in the villages with access to improved water supply. Future studies on rural domestic water consumption should pay more attention to user lifestyles (water appliance usage habits, outdoor water use and cultural backgrounds (age, education.

  5. Erken Tabgaç (T’o-pa Tarihinin Ana Hatları (Wei Shu’nun İlk Bölümüne Göre Outlines of Early Tabgach (T’o-pa History (According to First Chapter of Wei Shu

    Directory of Open Access Journals (Sweden)

    Kürşat YILDIRIM

    2012-09-01

    Full Text Available The History of Tabgach Turks who recorded in Chinese sources under the name of T’o-pa is little known. Tabgachs dominated on Northern China in 386 AD, governed China for nearly two centuries and finally disappeared from the stage of history by becoming Chinese people. Some scholars investigated this period of Tabgachs. However, their emergence to stage of history and their history until 386 AD are little studied. Tabgachs begun to take place in the Chinese sources in years about 160-170. They strengthened their state formation anddominated on all of their neighbors in the period of Li-wei (220-277.They established Tai State under the reign of I-lu in 314 and this statelasted until 376. Especially in the reign of Shih-i-chien (338-376,Tabgach State strengthened and extended its domination from Liaoningin east to Ferghana in west. Largest state formation of Tabgachs isNorthern Wei State that dominated all of China and later becameChinese. Our article aims to study this period lasted until 386 based onfirst chapter of Wei Shu that is official dynastic history of TabgachDynasty. Besides this, it is applied to main sources as Shih Chi, HanShu, Hou Han Shu, San Kuo Chih, Chin Shu, T’ai P’ing Yü Lan, Ts’e FuYüan Kuei, T’ung Chih, Wen Hsien T’ung Kao, Tzu Chih T’ung Chien,T’ung Tien and research studies. We hope to contribute to later studieson political history, linguistics, cultural history about Tabgachs withour study in General Turkic History. Çin kaynaklarında T’o-pa adı altında kaydedilen Tabgaç Türklerinin tarihleri az bilinmektedir. Tabgaçlar M.S. 386 yılında Kuzey Çin’e hâkim oldular, yaklaşık iki yüzyıl Çin’i idâre ettiler ve nihayetinde Çinlileşip tarih sahnesinden çekildiler. Bazı âlimler Tabgaçların bu devrini incelemişlerdir. Bununla beraber Tabgaçların tarih sahnesine çıkışları ve 386 yılına kadar olan tarihleri pek çalışılmamıştır. Tabgaçlar 160-170 yıllarında

  6. Contamination and Human Health Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Oysters After the Wu Yi San Oil Spill in Korea.

    Science.gov (United States)

    Loh, Andrew; Yim, Un Hyuk; Ha, Sung Yong; An, Joon Geon; Kim, Moonkoo

    2017-07-01

    After the collision of the Singapore-registered oil tanker M/V Wu Yi San into the oil terminal of Yeosu, Korea on January 31, 2014, approximately 900 m 3 of oil and oil mixture were released from the ruptured pipelines. The oil affected more than 10 km of coastline along Gwangyang Bay. Emergency oil spill responses recovered bulk oil at sea and cleaned up the stranded oil on shore. As part of an emergency environmental impact assessment, region-wide monitoring of oil contamination in oyster had been conducted for 2 months. Highly elevated concentrations of polycyclic aromatic hydrocarbons (PAHs) were detected at most of the spill affected sites. Four days after the spill, the levels of PAHs in oysters increased dramatically to 627-81,000 ng/g, the average of which was 20 times higher than those found before the spill (321-4040 ng/g). The level of PAHs in these oysters increased until 10 days after the spill and then decreased. Due to the strong tidal current and easterly winter winds, the eastern part of the Bay-the Namhae region-was heavily contaminated compared with other regions. The accumulation and depuration of spilled oil in oyster corresponded with the duration and intensity of the cleanup activities, which is the first field observation in oil spill cases. Human health risk assessments showed that benzo[a]pyrene equivalent concentrations exceeded levels of concern in the highly contaminated sites, even 60 days after the spill.

  7. Frederick Yi-Tung Cho (1939-2011) : His PhD days in Biophysics, the Photosynthesis Lab, and his patents in engineering physics.

    Science.gov (United States)

    Govindjee; Munday, John C; Papageorgiou, George C

    2017-06-01

    We present here a Tribute to Frederick Yi-Tung Cho (1939-2011), an innovative and ingenious biophysicist and an entrepreneur. He was one of the 4 earliest PhD students [see: Cederstrand (1965)-Carl Nelson Cederstrand; coadvisor: Eugene Rabinowitch; Papageorgiou (1968)-George C. Papageorgiou (coauthor of this paper); and Munday (1968)-John C. Munday Jr. (also a coauthor of this paper)] of one of us (Govindjee) in Biophysics at the University of Illinois at Urbana-Champaign (UIUC) during the late 1960s (1963-1968). Fred was best known, in the photosynthesis circle for his pioneering work on low temperature (down to liquid helium temperature, 4 K) absorption and fluorescence spectroscopy of photosynthetic systems; he showed temperature independence of excitation energy transfer from (i) chlorophyll (Chl) b to Chl a and (ii) from Chl a 670 to Chl a 678; and temperature dependence of energy transfer from the phycobilins to Chl a and from Chl a 678 to its suggested trap. After doing research in biophysics of photosynthesis, Fred shifted to do research in solid-state physics/engineering in the Government Electronics Division (Group) of the Motorola Company, Scottsdale, Arizona, from where he published research papers in that area and had several patents granted. We focus mainly on his days at the UIUC in context of the laboratory in which he worked. We also list some of his papers and most of his patents in engineering physics. His friends and colleagues have correctly described him as an innovator and an ingenious scientist of the highest order. On the personal side, he was a very easy-going and amiable individual.

  8. On the hydrology and fluvial sediment transport of the proglacial river Riffler Bach (Weißseeferner, Ötztal Alps, Tyrol)

    Science.gov (United States)

    Morche, David; Baewert, Henning; Weber, Martin; Schmidt, Karl-Heinz

    2013-04-01

    The hydrology of proglacial rivers is strongly affected by glacier melting. With ongoing glacier retreat the proportion of glacier meltwater in proglacial rivers is declining over longer time periods. Snow melt or rain fall events will play a more important role as water source. Due to glacial erosion the glacier system is also an important player in the orchestra of sediment sources/processes contributing to proglacial sediment budgets. The consequence of increasing deglaciation is a growing importance of other sediment sources/processes, mainly known as paraglacial, for sediment budgets in glacier forefields. The sediment export out of proglacial areas is mainly done by solid river load. Knowledge on the quantity of the exported sediments is important for reservoir management and torrent control. In order to measure fluvial sediment transport in the catchment area of the Gepatsch reservoir in the Ötztal Alps (Tyrol/Austria) we have installed a gauging station at the proglacial river Riffler Bach in June 2012. The catchment area of this station is about 20 km² with an altitudinal range from 1929 m to 3518 m. The higher altitudes in the southern part of the area are covered by the glacier Weißseeferner. Our station is equipped with an automatic water sampler (AWS 2002) and probes for water level, turbidity and electrical conductivity. All parameters are recorded in 5-15 minute intervals during the ablation period. Discharge is measured with current meters during wadable stages and salt dilution during higher floods. Bed load is measured concurrent to discharge measurements using a Helley-Smith sampler. In 2012, 189 water samples were taken and will be analyzed for suspended sediment concentration and ion content. Additionally, the grain size distribution will be determined using a Malvern laser diffractometer. Rating-curves will be used to calculate discharge from stage recordings. Solid load of the Riffler Bach will be quantified using the discharge data and

  9. [Study on gene differential expressions of substance and energy metabolism in chronic superficial gastritis patients of Pi deficiency syndrome and of pi-wei hygropyrexia syndrome].

    Science.gov (United States)

    Yang, Ze-Min; Chen, Wei-Wen; Wang, Ying-Fang

    2012-09-01

    To analyze the metabolic levels of energy and substance in chronic superficial gastritis (CSG) patients of Pi deficiency syndrome (PDS) and of Pi-Wei hygropyrexia syndrome (PWHS), including lipid, protein, nucleic acid, carbohydrate, trace element, and energy metabolism, and to study the pathogenesis mechanism of PDS from substance and energy metabolisms. Recruited were 8 CSG patients who visited at First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and Guangdong Provincial Hospital of Traditional Chinese Medicine from June 2004 to March 2005, including 4 patients of PDS and 4 of PWHS. Their gastric mucosae were used for experiments of DNA microarray. The dual-channel DNA microarray data were bioinformatically analyzed by BRB ArrayTools and IPA Software. Obtained were fifty-six differentially expressed genes involved in substance and energy metabolisms with the expression fold more than 2, including 11 genes up-regulated and 45 genes down-regulated. Of them, genes correlated to lipid metabolism included CRLS1, LRP11, FUT9, GPCPD1, PIGL, SULT1A4, B3GNT1, ST8SIA4, and ACADVL, mainly involved in the metabolic processes of fatty acid, cholesterol, phospholipids, and glycolipid. Genes correlated to protein metabolism included ASRGL1, AARSD1, EBNA1BP2, PUM2, MRPL52, C120RF65, PSMB8, PSME2, UBA7, RNF11, FBXO44, ZFYVE26, CHMP2A, SSR4, SNX4, RAB3B, RABL2A, GOLGA2, KDELR1, PHPT1, ACPP, PTPRF, CRKL, HDAC7, ADPRHL2, B3GNT1, ST8SIA4, DDOST, and FUT9, mainly involved in the biosynthesis processes of protein, ubiquitination, targeted transport and post-translation modification. Genes correlated to nucleic acid metabolism included DFFB, FLJ35220, TOP2A, SF3A3, CREB3, CRTC2, NR1D2, MED6, GTF2IRD1, C1ORF83, ZNF773, and ZMYND11, mainly involved in DNA replication and repair, transcription regulation. Genes correlated to carbohydrate metabolism included AGL, B3GNT1, FUT9, ST8SIA4, SULT1A4, DDOST, and PIGL, mainly involved in glucogen degradation and

  10. Relationship between Lower Motor Neuron Atrophy and Wei Syndrome in Su Wen%下运动神经元瘫与《素问》痿病相关性分析

    Institute of Scientific and Technical Information of China (English)

    唐东一

    2016-01-01

    The clinical manifestations of the lower motor neuron atrophy are muscle weakness ,muscle atro-phy and fasciculation. They are similar to the wei disease described in Su Wen Wei Lun,which manifests as weak feet,claw dry and muscle tremor. Actually the muscle tremor is fasciculation,not the weakness and flaccidity of the muscles. Wei disease includes motor neuron disease or other lower motor neuron paralysis disease of the modern medicine,but not includes the upper motor neuron paralysis and muscle atrophy myo-genic disease. According to the theory that “treatment of atrophy should be focused on yangming channel”, invigrating spleen and tonifying stomach could achieve satisfactory effects.%下运动神经元瘫临床表现的肌无力、肌萎缩和肌束震颤与《素问·痿论》所述痿病之足痿不用、爪枯、肉蠕动相似。肉蠕动是指肌束颤动,而非肌肉软弱无力。根据临床表现,痿病应包含现代医学的运动神经元病或其他下运动神经元瘫痪性疾病,而不包含上运动神经元瘫和肌源性肌萎缩疾病。根据“治痿独取阳明”的理论,应用健脾养胃法治疗此类疾病效果较好。

  11. A comparative pharmacokinetic study of three flavonoids and three anthraquinones in normal and gastrointestinal motility disorders rat plasma after the oral administration of Wei-Chang-Shu tablet using high-performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Ren, Yan; Zhao, Weiwei; Zhao, Juanjuan; Chen, Xiangming; Yu, Chen; Liu, Mengan

    2017-11-01

    A simple, fast and reliable high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification and pharmacokinetic study of three flavonoids (liquiritigenin, isoliquiritigenin and formononetin) and three anthraquinones (emodin, rhein and aloe-emodin), which are the bioactive ingredients of Wei-Chang-Shu tablet found in rat plasma. After extraction by liquid-liquid extraction with ethyl acetate, chromatographic separation was achieved on an Agilent Zorbax SB-C 18 column (4.6 × 150 mm, 5 μm) at a flow rate of 1 mL/min by gradient elution using 0.1% aqueous acetic acid and acetonitrile. The detection was performed using a triple quadrupole mass spectrometer equipped with electrospray ionization source in the negative ionization and selected reaction monitoring mode. Method validation was performed in terms of specificity, carryover, linearity (r > 0.99), intra-/inter-day precision (1.0-10.1%), accuracy (relative error, <7.6%), stability (0.6-13.2%), extract recovery (74.9-91.9%) and matrix effect (89.1-109%). The lower limits of quantification of the six analytes varied from 0.92 to 10.4 ng/mL. The validated method was successfully applied to compare the pharmacokinetic properties of Wei-Chang-Shu tablet in normal rats and in rats with gastrointestinal motility disorders. The results indicated that there were obvious differences in the pharmacokinetic behavior between normal and model rats. This study will be helpful in the clinical application of Wei-Chang-Shu tablet. Copyright © 2017 John Wiley & Sons, Ltd.

  12. Evaluation of the effects of ethinylestradiol on sexual differentiation in the olvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity of germ cells

    International Nuclear Information System (INIS)

    Hano, Takeshi; Oshima, Yuji; Kinoshita, Masato; Tanaka, Minoru; Mishima, Noriko; Wakamatsu, Yuko; Ozato, Kenjiro; Shimasaki, Yohei; Honjo, Tsuneo

    2011-01-01

    We evaluated the effects of 17(-ethinylestradiol (EE 2 ) on sexual differentiation in transgenic olvas-GFP/STII-YI medaka (Oryzias latipes) in terms of the proliferative activity of germ cells. This strain contains the green fluorescent protein (GFP) gene fused to the regulatory region of the medaka vasa gene, and germ cell-specific expression of GFP can be visualized in living (transparent) individuals. From 0 days post-hatch (0 dph) onwards, juveniles were exposed to graded concentrations of EE 2 (25.2-1710 ng/L) for 35 days. The gonads of live specimens were monitored by measuring their size and calculating their GFP-fluorescence area. GFP-fluorescent area in control females was about 10 times that in control males at 10 days posthatch (dph) whereas the gonadal size of 10 dph males that had been exposed to 158 ng/L of EE 2 significantly increased up to twice the size of control males, indicating that abnormal sexual differentiation towards female might occur in these individuals. Histological examination and identification of the sex-linked marker SL1 indicated that male to female sex reversal occurred at EE 2 exposure ≥45.1 ng/L at 35 dph. These results suggest that observation of proliferative activity of germ cells in the olvas-GFP/STII-YI strain could be applied to facilitated screening fish model to detect adverse effects on sexual differentiation as early as 10 dph juveniles.

  13. 2483-IJBCS-Article-Dr Akpo Yao

    African Journals Online (AJOL)

    hp

    2Ecole Polytechnique d'Abomey-Calavi - Laboratoire de Recherche en Biologie Appliquée (LARBA),. Unité de Recherche Cunicole et Cavicole (URCC), 01 BP 2009 Cotonou, Bénin. 3INRA - Tours, Laboratoire de Pathologie du ... une prophylaxie vaccinale est mise au point. La réussite d'une telle innovation passe par la.

  14. 1528-IJBCS-Article-Yao Kouakou

    African Journals Online (AJOL)

    hp

    satisfaire les besoins en protéines des populations (FAO, 2011). En Côte .... 20% de lipides et 3% de fibres, à la ration de. 10% de la biomasse pendant les 56 .... moyen quotidien; TCSP = Taux de croissance spécifique pondérale; TCSL = Taux de croissance spécifique linéaire; ICa = Indice de consommation apparent.

  15. 2367-IJBCS-Article-Koffi Mathias Yao

    African Journals Online (AJOL)

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    comportement serait lié au prix de vente des différents alcools. C'est pourquoi, la publicité ... troubles physiques et mentaux, parmi lesquels ... consommation de 5 verres chez l'homme ou ... consomme trois à quatre verres, au plus une fois par ...

  16. 1809-IJBCS-Article-Hoekou Yao

    African Journals Online (AJOL)

    hp

    Original Paper http://indexmedicus.afro.who.int. Évaluation des propriétés antimicrobiennes de Pterocarpus erinaceus Poir. (Faboïdeae) et Daniellia oliveri (Rolfe) Hutch. et Dalz (Caesalpinoïdeae), utilisées en médecine traditionnelle au Togo. Nassifatou Koko TITTIKPINA 1, Amégninou AGBAN 2,Koffi Apeti GBOGBO 1,.

  17. 341-IJBCS-Article-Yao Koffi Marcelin

    African Journals Online (AJOL)

    Dr Gatsing

    est bien oxygénée et présente des signes d'un dépôt des particules minérales. Les résultats des teneurs en sels nutritifs révèlent que les teneurs en ammonium de certaines zones affectent la vie aquatique et que les principales sources de sels nutritifs sont les rejets domestiques et industriels, les eaux de ruissellement et.

  18. 70994-179427-Yao et al- +DOI

    African Journals Online (AJOL)

    confo

    ) est notée. Ces deux modalités se trouvent éloignées du nuage de points formé en grande partie par les anomalies cliniques et para-cliniques. Toutefois, la modalité. « BAIND » est plus éloignée du nuage par rapport à la modalité « MEL ».

  19. 1758-IJBCS-Article-Hoekou Yao

    African Journals Online (AJOL)

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    albicans, une levure isolée du prélèvement vaginal chez une malade atteinte de candidose au Laboratoire de Microbiologie du Centre. Hospitalier Universitaire Sylvanus Olympio. (Togo). Extraction. L'extraction a été réalisée dans le. Laboratoire de chimie de l'Ecole Supérieure des Techniques Biologiques et Alimentaires.

  20. 1420-IJBCS-Article-Theodore K. Yao

    African Journals Online (AJOL)

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    Évaluation de la potabilité chimique des eaux souterraines dans un bassin versant tropical : cas du .... motricité humaine ou électrique dont les profondeurs varient entre 10 ...... relationships in groundwater from central. Sao Paulo State Brazil.

  1. 2140-IJBCS-Article-Koffi Marcelin Yao

    African Journals Online (AJOL)

    hp

    Mots clés : Métaux traces, matière organique, adsorption, désorption, Estuaire. INTRODUCTION. La contamination de l'atmosphère, de l'hydrosphère et des sédiments par les métaux lourds est aujourd'hui très préoccupant pour les pays développés et émergents. Les métaux lourds sont des éléments métalliques dont la.

  2. 2168-IJBCS-Article-Yao Brou

    African Journals Online (AJOL)

    hp

    Le monitoring des éléments traces métalliques (ETM) de l'environnement et des réseaux trophiques a considérablement gagné du terrain durant ces dernières décennies afin de prévenir les problèmes environnementaux et de santé publique. Cette étude s'inscrit dans ce contexte de monitoring et entend évaluer le niveau ...

  3. On Yi Concert "China' s memory, A Torch in the cloud"%浅谈《中国记忆·云中火把》彝族音乐会

    Institute of Scientific and Technical Information of China (English)

    张虎

    2012-01-01

    《中国记忆·云中火把》在上海音乐厅的成功演出,标志着楚雄彝族音乐走向世界的开始,音乐会的演出成功是楚雄、上海两地艺术家们交流、合作、共同努力的结果。以此为契机,努力打造更加优秀的音乐作品,来赢得人们对彝族音乐的认可。%The successful performance of "China' s memory, a torch in the cloud" in Shanghai concert hall marks the beginning of Yi music going global, to which the artists contribute through their communication, cooperation and joint effort. Taking this opportunity, we should create more good music works to win the world' s recognition.

  4. VALIDASI MODIFIKASI METODE WEIßHAAR UNTUK ANALISIS 3-MCPD ESTER DALAM MINYAK GORENG SAWIT [Validation of Modified Weißhaar’s Method for 3-MCPD Esters Analysis in Palm Oil

    Directory of Open Access Journals (Sweden)

    Tanti Lanovia1,2*

    2014-12-01

    Full Text Available The 3-monochloropropane-1,2-diol (3-MCPD and 3-MCPD esters were found in any type of refined vegetable oil -mostly produced during the refining process- and recognized as emerging food contaminants. Several analytical methods have been developed and one of which was a Weißhaar's method. The study aims to validate the modified Weißhaar's method for analysis of 3-MCPD and 3-MCPD esters in refined palm oil. Ion fragments were used for identification and quantification of 3-MCPD and 3-MCPD-d5. 3-MCPD was determined by GC-MS after released from its ester by transesterification with sodium methoxide and derivatized with phenylboronic acid. The validation showed that liniarity response (r=0.994 was observed from a linear regression by using external standard and internal standard at a concentration range of 0.008 and 0.377 µg mL-1. The LOD of the validated method was 0.06 µg g-1 while its LOQ was 0.20 µg g-1, precision (relative standard deviation, RSD was 6.16%, and accuracy (as percentage of recovery was in the range of 95.83-113.27%. This results indicated that the modified method was valuable and sensitive for detection of 3-MCPD and 3-MCPD esters. Using the validated method, 3-MCPD esters content of a commercial palm oil sample was determined and calculated as the difference between total 3-MCPD and free 3-MCPD, which was 13.24 µg g-1. Total 3-MCPD content of several palm oils were at a concentration range of 13.94-34.52 µg g-1. These results also showed that there was a correlation between 3-MCPD with diacylglyceride (DAG. Samples with DAG content gave a high test results of 3-MCPD with a coefficient of correlation of r=0.752.

  5. Simultaneous Qualitative and Quantitative Analysis of Multiple Chemical Constituents in YiQiFuMai Injection by Ultra-Fast Liquid Chromatography Coupled with Ion Trap Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Chunhua Liu

    2016-05-01

    Full Text Available YiQiFuMai injection (YQFM is a modern lyophilized powder preparation derived from the traditional Chinese medicine Sheng-mai san (SMS used for treating cardiovascular diseases, such as chronic heart failure. However, its chemical composition has not been fully elucidated, particularly for the preparation derived from Ophiopogon japonicus. This study aimed to establish a systematic and reliable method to quickly and simultaneously analyze the chemical constituents in YQFM by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UFLC-IT-TOF/MS. Sixty-five compounds in YQFM were tentatively identified by comparison with reference substances or literature data. Furthermore, twenty-one compounds, including three ophiopogonins, fifteen ginsenosides and three lignans were quantified by UFLC-IT-TOF/MS. Notably, this is the first determination of steroidal saponins from O. japonicus in YQFM. The relative standard deviations (RSDs of intra- and inter-day precision, reproducibility and stability were <4.9% and all analytes showed good linearity (R2 ≥ 0.9952 and acceptable recovery of 91.8%–104.2% (RSD ≤ 5.4%, indicating that the methods were reliable. These methods were successfully applied to quantitative analysis of ten batches of YQFM. The developed approach can provide useful and comprehensive information for quality control, further mechanistic studies in vivo and clinical application of YQFM.

  6. Study of Cu-doping effects on magnetic properties of Fe-doped ZnO ...

    Indian Academy of Sciences (India)

    Administrator

    To take into account the random distribution of ... and spin–orbit interaction were taken into account. .... Lee H J, Jeong S-Y, Ryong Cho C and Hong Park C 2002 Appl. Phys. Lett. ... Zhang Hua-Wei, Wei Zhi-Ren, Li Zhi-Qiang and Dong Guo-Yi.

  7. 从钱乙五脏辨证论治抽动障碍理论探讨%Theoretical Discussion of Treating Tic Disorder with Five-Zang Syndrome Differentiation of QIAN Yi

    Institute of Scientific and Technical Information of China (English)

    贾慧; 钞建峰

    2017-01-01

    Five-zang syndrome differentiation of QIAN Yi has important value for the diagnosis and treat-ment of tic disorder in children. Tic disorder involves more than one zang organ ,and it usually affects five zang organs at the same time. Liver wind is the core of disease mechanism ,usually with lung deficiency at-tacked by external leading to internal wind,or with spleen deficiency leading to wood over inhibiting earth, or heart heat with wind fire,or with yin deficiency failing to nourish wood. The treatment should follow the principle of tonfiying and purging five zang organs,that extinguishing liver wind is the essential method,in combination with clearing and dispersing lung qi,or with tonifying earth and suppressing wood,or with clear-ing heart fire,or with nourishing yin and tonifying kidneys.%钱乙五脏辨证对儿童抽动障碍的辨治具有重要的价值.抽动障碍非一脏之病,而是"五脏同病",肝风为病机之核心,或兼肺虚受邪、外风引动内风,或兼脾虚土衰、木乘脾土,或兼心热火旺、风火相搏,或兼肾阴亏虚、水不涵木.治疗尊五脏补泻的原则,以调肝熄风为本,针对不同的病机,或清宣肺气,或扶土抑木,或清心泻火,或养阴补肾.

  8. Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan.

    Science.gov (United States)

    Chao, Te-Hsin; Fu, Pin-Kuei; Chang, Chiung-Hung; Chang, Shih-Ni; Chiahung Mao, Frank; Lin, Ching-Heng

    2014-08-08

    Traditional Chinese medicine (TCM) is commonly provided to cancer patients, however, the patterns of prescriptions for this type of medicine in Taiwan are unclear. This study aimed to evaluate the use of traditional Chinese medicine products in colon cancer patients post-surgery in Taiwan and to research patterns of TCM. This was a cross-sectional study of newly diagnosed colon cancer patients who received surgery between 2004 and 2008 identified from the National Health Insurance Research Database of Taiwan. The prescription patterns and reasons for the use of TCM for colon cancer were analyzed. The results showed that "symptoms, signs and ill-defined conditions" (23.3%) and diseases of the digestive system (16.9%) were the most common reasons for using Chinese herbal medicine. Xiang-sha-liu-jun-zi-tang (7.1%), Bu-zhong-yi-qi-tang (4.3%), Jia-wei-xiao-yao-san (4.1%), Shen-Ling-Bai-Zhu-San (3.7%), Ban-Xia-Xie-Xin-Tang (3.4%), Gui-pi-tang (2.4%), Ping-Wei-San (2.4%), Gan-Lu-Yin (2.0%), Bao-He-Wan (1.9%), and Zhen-Ren-Huo-Ming-Yin (1.8%) were the most commonly prescribed single Chinese herbal formulae (CHF) for colon cancer patients post-surgery. Hedyotis diffusa Willd (Bai Hua She She Cao) (5.1%) and Scutellaria barbata (Ban Zhi Lian )(4.8%) were the most commonly prescribed single Chinese herbs. This study identified patterns of TCM use in colon cancer patients post-surgery in Taiwan. The herbal ingredients were most commonly used for stimulate ghrelin secretion to increase food intake and had potential anti-tumor effect. However, further research is required to evaluate any beneficial effects which could identify leads for the development of new treatment strategies using TCM. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

    Directory of Open Access Journals (Sweden)

    Zhang W

    2016-11-01

    Full Text Available Wen Zhang,1 Ruizhen Zhao,1 Xiaoli Li,1 Xia Cui,1 Zijun Zhao,1 Yingqiu Mao,2 Fengzhi Wu,3 Qisheng Tang1 1Department of Encephalopathy, The Third Affiliated Hospital, 2Center of Scientific Research, 3Center of Journals, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of China Background: The Yi-nao-jie-yu decoction (YNJYD is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA. The neuroendocrine–immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine–immune system in a rat model of PSA.Materials and methods: The PSA model was induced by injecting collagenase (type VII into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks. The sham group and the PSA model group were gavaged with saline, while the treatment groups received buspirone (BuSpar or YNJYD. Behavior was evaluated with the open field test and elevated plus maze once a week. Pathological changes were observed by hematoxylin and eosin staining. Serum levels of tumor necrosis factor, interleukin (IL-6, adrenocorticotropic hormone, thyroid stimulating hormone, free triiodothyronine, free thyroxine, IL-1α, and cortisol were detected by radioimmunoassay. Expression of the γ-aminobutyric acid type A receptor (GABAAR α2 subunit was examined by Western blot and real-time polymerase chain reaction.Results: YNJYD-treated rats exhibited significantly better recovery than BuSpar-treated rats at 21 days and 28 days in the open field test and elevated plus maze. Hematoxylin and eosin staining revealed neural repair in the hippocampus in the treatment groups. Serum levels of IL-1α in the YNJYD group were significantly less than those in the model group and the Bu

  10. On the use of COSMO-SkyMed time series for the identification of Archaeological traces dating from the Eastern-Han to Northern-Wei Dynasties in Luoyang city.

    Science.gov (United States)

    Chen, Fulong; Masini, Nicola; Yang, Ruixia; Feng, Dexian; Lasaponara, Rosa

    2015-04-01

    The availability of Very High Resolution (VHR) Synthetic Aperture SAR (SAR) data (Lasaponara and Masini 2013, Tapete et al. 2013), such as TerraSAR-X and Cosmo Sky Med launched in 2007, opened a new era in the spaceborne SAR remote sensing, including archaeology remote sensing previous mainly based on optical data (see for example Lasaponara and Masini 2012, Ciminale et al. 2009, Masini and Lasaponara 2006). They provide powerful tools, based on active sensors from space operating in the microwave frequency range, which are useful to extract information about the contemporary landscape and make possible, in some conditions, to infer changes in the former environment and to detect archaeological remains. Nevertheless, the capability of satellite radar technology in archaeology has so far not been fully assessed. This paper (Chen et al 2015) is a pioneering effort to assess the potential of satellite SAR X-band data in the detection of archaeological marks. We focus on the results obtained from a collaborative contribution jointly carried out by archaeologists and remote sensing experts in order to test the use of COSMO-SkyMed data in different contexts and environmental conditions. The methodological approach we adopted is based on multi-temporal analysis performed to reduce noise and highlight archaeological marks. Results from multi-temporal data analysis, conducted using 40 scenes from COSMO-SkyMed X-band Stripmap data (27 February to 17 October 2013), enable us to detect unknown archaeological crop, soil, and shadow marks representing Luoyang city, dating from the Eastern-Han to Northern-Wei Dynasties. Reference Chen F., Masini N., Yang R., Milillo P., Feng D., Lasaponara R., 2015 A Space View of Radar Archaeological Marks: First Applications of COSMO-SkyMed X-Band Data. Remote Sens. 2015, 7, 24-50; doi:10.3390/rs70100024. Lasaponara R., Masini N. 2013, Satellite Synthetic Aperture Radar in Archaeology and Cultural Landscape: An Overview. Archaeological

  11. Lubâb At-Ta’wîl ‘Inda Al-Imâm Al-Khâzîn Baina Al-Ma’tsûr wa Ar-Ra’yi (Dirâsah Maudhu’iyyah fi Ayah al-Qashash

    Directory of Open Access Journals (Sweden)

    Muhammad Shulhi Alhadi siregar

    2018-03-01

    Full Text Available This paper concern to study about one of Tafseer book, namely Lubâb al-Ta'wîl fi Ma'âny at-Tanzîl by Imam al-Khazin. Some scholars differ in the setting of sources of tafseer. Such as, the well-known scholars, Muhammad Ali Iyazi and Muhammad Husain ad-Dzahabi. Ulama Iyazi assumes that Tafseer Khazin belongs to the category of commentary bi al-Ma'tsûr, since this commentary is an ikhtishar of Tafseer al-Baghawi. While some scholars such as adz-Dzahabi, categorized this tafseer into the bi al-Ra'yi. By using the tahlily documentation method and the thematic method associated with Qashash verses in the Qur'an, the researchers found the correct method, namely the tafseer of al-Atsary an-Nazhary or known by tafseer bi al-Ma'tsûr who use Ra'yi as an extension of explanation and the determination of the most powerful law, seen from writing theme related at the end of its tafseer.

  12. 2547-IJBCS-Article-Dr Koffi Marcelin yao

    African Journals Online (AJOL)

    hp

    cible biologique, les pesticides sont classés en plusieurs familles parmi lesquels figurent les insecticides, les nématicides (contre les nématodes), les herbicides, les fongicides. (contre les champignons) et les rodenticides. Selon leurs structures chimiques ou groupes fonctionnels, l'on distingue aussi plusieurs familles dont ...

  13. 1016-IJBCS-Article-Dr Koffi Mathias Yao

    African Journals Online (AJOL)

    DR GATSING

    d'alcool, de sexe masculin dont 50 sujets témoins et 346 sujets tests répartis en deux groupes : 173 ont ... deux groupes de sujets tests ont des performances semblables comme ce fut le cas ..... Harris DS, Everhart ET, Mendelson J, Jones.

  14. 1016-IJBCS-Article-Dr Koffi Mathias Yao

    African Journals Online (AJOL)

    DR GATSING

    Pastis 45), des ... Ces sujets sont des consommateurs occasionnels des deux types ... Cependant, trois heures après cette consommation, les performances des sujets tests au Koutoukou de vin de ... d'organisation des tâches (Giancola et al.,.

  15. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China.

    Science.gov (United States)

    Zhang, Chan; He, Yan; Shan, Ke-Ren; Tan, Kui; Zhang, Ting; Wang, Chan-Juan; Guan, Zhi-Zhong

    2018-02-01

    Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection. Results A total of 404 subjects were enrolled in the study: 138 from the Yao group, 101 from the Yi group and 165 from the Han group. There was a significant difference in the frequency of UGT1A1 rs8175347 polymorphisms among the three groups. The rates of 7TA carriers of UGT1A1 rs8175347 in all three groups were significantly higher than the other genotypes. Individuals with genotype AA of UGT1A6 rs2070959 in the Yi group had a higher risk for HBV infection than in the Yao and Han groups. The frequency of genotype GG in CCR5-59029 in the Yao group was significantly higher than in the Yi group. The genotypes of CCR5Δ32 were not associated with HBV infection. Conclusion These findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5-59029 polymorphisms with HBV infection in Chinese Yi and Yao populations.

  16. Right Sizing the People’s Liberation Army: Exploring the Contours of China’s Military

    Science.gov (United States)

    2007-09-01

    Diyuan yu Zhongguo Haijun Jianshe” (“Stratgeic Geography and the Development of China’s Navy”), Shijie Jingji yu Zhengzhi (World Economics and...on conventional [missile forces] (hechang jianbei, yi chang wei zhu ); • Bring out focal points, put priority on quality (tuchu zhongdian, zhiliang...Juece” [“2nd Artillery Command & Control Decision- Making During a Joint Campaign”], Junshi Xueshu, July 2004, p. 65. 30. Shang Yi, “ Zhu Chenghu

  17. Right-Sizing the People’s Liberation Army: Exploring the Contours of China’s Military

    Science.gov (United States)

    2007-09-01

    yu Zhongguo Haijun Jianshe" ("Stratgeic Geography and the Development of China’s Navy"), Shijie Jingji yu Zhengzhi (World Economics and Politics...They are: "* Maintain conventional and nuclear [missile forces], but put priority on conventional [missile forces] (hechang jianbei, yi chang wei zhu ...Zuozhan Zhihui Juece" [Ŗnd Artillery Command & Control Decision- Making During a Joint Campaign"], Junshi Xueshu, July 2004, p. 65. 30. Shang Yi, " Zhu

  18. Downregulation of ALDOB is associated with poor prognosis of patients with gastric cancer

    Directory of Open Access Journals (Sweden)

    He J

    2016-10-01

    Full Text Available Jun He,1 Yi Jin,1 Yuan Chen,2 Hai-Bo Yao,1 Ying-Jie Xia,3 Ying-Yu Ma,4 Wei Wang,2 Qin-Shu Shao1 1Department of Gastroenterology and Pancreatic Surgery, 2Department of Pathology, 3Key Laboratory of Gastroenterology of Zhejiang Province, 4Clinic Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, People’s Republic of China Objectives: To examine the expression of ALDOB in gastric cancer (GC tissue and to reveal its potential clinicopathological and prognostic significance.Materials and methods: We screened for genes that were differentially expressed between GC and nontumor tissues using a microarray, specifically the Affymetrix U133 Plus 2.0 Array platform. We then verified the transcriptional and translational levels of ALDOB by performing quantitative real-time polymerase chain reaction (qRT-PCR and immunohistochemistry (IHC. In addition, a merged data set based on the Gene Expression Omnibus was generated and a survival analysis performed.Results: The microarray analysis revealed that ALDOB was downregulated (more than sevenfold in GC compared with nontumor tissue. Both qRT-PCR and IHC validated the decrease of ALDOB in GC tissue. Moreover, we found that the expression of ALDOB was significantly related to tumor-invasion depth, lymph-node metastasis, distant metastasis, and TNM stage. The survival analysis, based on the IHC and merged data set, indicated that the overall survival was better in patients with high ALDOB expression. The Cox regression analysis showed that ALDOB expression was an independent prognostic factor for GC.Conclusion: The expression of ALDOB in GC tissue was significantly related to the clinicopathological features and prognosis of the disease, thus suggesting that ALDOB could act as a novel molecular marker for GC. Keywords: ALDOB, gastric cancer, microarray analysis, molecular marker

  19. Tempêtes sanglantes sur les hautes terres tibétaines

    OpenAIRE

    Jie, Yu

    2011-01-01

    Woeser (Wei Se), Sha jie. Sishi nian de jiyi jinqu. Jingtou xia de Xizang wenhua. Di yi ci gongkai. (Massacres et pillages. Mémoire interdite depuis 40 ans. La culture tibétaine sous un objectif pour la première fois) Forbidden memory. Tibet during the Cultural Revolution, Taipei, Dakuai wenhua, 2006, 296 p.

  20. DNA damage and decrease of cellular oxidase activity in piglet ...

    African Journals Online (AJOL)

    DNA damage and decrease of cellular oxidase activity in piglet sertoli cells exposed to gossypol. Ming Zhang, Hui Yuan, Zuping He, Liyun Yuan, Jine Yi, Sijun Deng, Li Zhu, Chengzhi Guo, Yin Lu, Jing Wu, Lixin Wen, Qiang Wei, Liqun Xue ...

  1. A system-level mechanistic investigation of traditional Chinese ...

    African Journals Online (AJOL)

    Xiao-Hong Gu* ... targets related to lung and stomach diseases were searched and screened to avoid duplication. ... Liu et al. Trop J Pharm Res, August 2017; 16(8): 1910. On account of this deficiency in knowledge, ..... Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, ... Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2013;.

  2. Hawking Temperature of an Arbitrarily Accelerating Black Hole Wei ...

    Indian Academy of Sciences (India)

    Introduction. In 1974, Hawking (1974) made a striking discovery that black holes could produce thermal radiation. In this paper, we will obtain Hawking temperature of an arbitrarily accelerating black hole based on the Klein–Gordon equation, which is identical to the one obtained by the Hamilton–Jacobi equation under the ...

  3. Kippen in de wei is een ecologisch duurzame neventak.

    NARCIS (Netherlands)

    Bassler, A.; Oomen, G.J.M.

    1998-01-01

    To prevent problems with parasites and accumulation of manure, an experiment was performed with layers on pasture, together with cows and sheep. Calculations were made for additional feeding with cereals and the possible reduction in feed costs. The maximum number of chickens per ha on a pasture

  4. 78 FR 14556 - Cheng Yi Liang: Debarment Order

    Science.gov (United States)

    2013-03-06

    .... 1001 and securities fraud, a Federal felony offense under 15 U.S.C. 78j(b) and 78ff. FDA's finding that debarment is appropriate is based on the felony conviction for securities fraud referenced herein for... execution of trades on national securities exchanges, resulting in total profits and losses avoided of $3...

  5. From“Expression of Feelings” to“Landscape”:Independence of Image of landscape in Travelling Poems in Wei and Jin Dynasties%从“咏怀”到“山水”:魏晋羁旅行役诗中山水物色的独立之路

    Institute of Scientific and Technical Information of China (English)

    程磊

    2015-01-01

    羁旅诗长期遵循着言志抒情的咏怀思路,自然物象无法凸显独立出来,随着魏晋时代山水审美意识的勃兴以及山水游览风气的盛行,行旅诗也逐渐增加山水描写的比重,并将山水游赏与羁旅情思结合起来,二者融合才有谢灵运羁旅山水诗的出现。其间玄言山水诗以山水阐说玄理,注重祛情去累、以理遣情,将羁旅的困境体验导向证悟哲理玄境的解脱,山水显得外在而与诗人的精神世界难以相契,至南朝尤其是谢朓的宦游山水诗篇,山水形象与世俗生活情感相交融,才有羁旅山水诗歌传统的正式定型。从羁旅咏怀到羁旅山水,情事相生转变为情景相照,正是山水诗诞生的内在理路之一。%For a long time poems about intellectuals'business trip had followed the lyric pattern so the image of landscape could not be protruded .Due to the rise of landscape aesthetics and the fashion of landscape sightseeing in Wei and Jin Dynasties ,the proportion of landscape description in business trip poems had in‐creased ,as well as the combination with sightseeing and nostalgia ,which brought about Xie Lingyun's land‐scape poems .Before that ,landscape in metaphysical poems explained the metaphysics through landscape , emphasizing weakening of feelings and guiding predicament experience of intellectuals'business trip to un‐derstanding of philosophy .The external landscape could not agree with the poet's spirit .Not until the South Dynasty did the landscape and the worldly life integrated with each other and the tradition of landscape po‐ems about business trip is established .Landscape as a way of life emerges slowly during the poem‐evolving course .It is a clue for the landscape poems coming into being from interpromoting of feelings and experi‐ences to reflection between landscape and feelings .

  6. Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People's Republic of China

    Directory of Open Access Journals (Sweden)

    Cai BQ

    2014-04-01

    Full Text Available Bai-qiang Cai,1 Shao-xi Cai,2 Rong-chang Chen,3 Li-ying Cui,4 Yu-lin Feng,5 Yu-tong Gu,6 Shao-guang Huang,7 Rong-yu Liu,8 Guang-nan Liu,9 Huan-zhong Shi,10 Yi Shi,11 Yuan-lin Song,6 Tie-ying Sun,12 Chang-zheng Wang,13 Jing-lan Wang,1 Fu-qiang Wen,5 Wei Xiao,14 Yong-jian Xu,15 Xi-xin Yan,16 Wan-zhen Yao,17 Qin Yu,18 Jing Zhang,6 Jin-ping Zheng,3 Jie Liu,6 Chun-xue Bai6 1Department of Pulmonary Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Southern Medical University South Hospital, Guangzhou, 3The First Affiliated Hospital of Guangzhou Medical College and Guangzhou Institute of Respiratory Diseases, Guangzhou, 4Affiliate Hospital of Inner Mongolia Medical University, Huhehaote, 5Huaxi Hospital of Sichuan University, Chendu, 6Zhongshan Hospital, Shanghai Medical College, Fudan University and Shanghai Respiratory Research Institute, Shanghai, 7Ruijing Hospital of Shanghai Jiaotong University, Shanghai, 8The First Affiliated University of Anhui Medical University, Hefei, 9The First Affiliated University of Guangxi Medical University, Nanning, 10Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 11General Hospital of Nanjing Military Region, Nanjing, 12Beijing Hospital of the Ministry of Health, Beijing, 13Xinqiao Hospital, Third Military Medical University, Chongqing, 14Qilu Hospital of Shandong University, Jinan, 15Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 16The Second Affiliated Hospital of Hebei Medical University and Hebei Research Institute of Respiratory Medicine, Shijiazhuang, 17The Third Affiliated Hospital of Beijing University, Beijing, 18The First Affiliated University of Lanzhou University, Lanzhou, People's Republic of China Abstract: Chronic obstructive pulmonary disease (COPD is a common disease that severely threatens human health. Acute exacerbation of COPD (AECOPD is a major cause of

  7. Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A

    OpenAIRE

    Qi, Jianping; Ping ,Qineng

    2011-01-01

    Jianping Qi1,2, Jie Zhuang1, Wei Wu2, Yi Lu2, Yunmei Song3, Zhetao Zhang1, Jia Jia1, Qineng Ping11School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 2School of Pharmacy, Fudan University, Shanghai, People’s Republic of China; 3School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, AustraliaBackground: A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. ...

  8. Computer-aided Human Centric Cyber Situation Awareness

    Science.gov (United States)

    2016-03-20

    in Video, IJCAI: International Joint Conf. on Artificial Intelligence . 16-JUL-11, . : , Kun Sun, Sushil Jajodia, Jason Li, Yi Cheng, Wei Tang...Cyber-Security Conference, June 2015. 2. V.S. Subrahmanian, Invited Speaker, Summer School on Business Intelligence and Big Data Analysis, Capri, Italy... Cybersecurity Conference, Yuval Ne’eman Workshop for Science, Technology and Security, Tel Aviv University, the Israeli National Cyber Bureau, Prime

  9. The 2nd International Conference on Agricultural and Biological Sciences (ABS 2016)

    OpenAIRE

    Pei, Lei; Wang, Zhenhua; Zhang, Jinzhu; Li, Wenhao; Ting, Adeline S. Y.; Chow, Yiing Y.; Rahman, Sadequr; Wei, Rongchang; Hu, Zhang; Li, Sidong; Li, Chuyan; Li, Zijuan; Wang, Guoxia; Yang, Yuzhen; Chen, Gang

    2016-01-01

    Table of contents 01 The influence of soil salt content on the photosynthetic characteristics of spring wheat with trickle irrigation Lei Pei, Zhenhua Wang, Jinzhu Zhang, Wenhao Li 02 Comparing growth of fast-growing and slow-growing endophytes in plants via ergosterol quantification Adeline SY Ting, Yiing Y Chow, Sadequr Rahman 03 Transcriptome and digital gene expression analysis identifies putative triterpene saponin-biosynthetic genes of Panax notoginseng Rongchang Wei 04 Chitosan-assiste...

  10. New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

    Science.gov (United States)

    Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yi-Fan; Ko, Kam-Ming

    2011-01-01

    Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery. PMID:21785622

  11. New Perspectives on Chinese Herbal Medicine (Zhong-Yao Research and Development

    Directory of Open Access Journals (Sweden)

    Si-Yuan Pan

    2011-01-01

    Full Text Available Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery.

  12. VizieR Online Data Catalog: Mira stars discovered in LAMOST DR4 (Yao+, 2017)

    Science.gov (United States)

    Yao, Y.; Liu, C.; Deng, L.; de Grijs, R.; Matsunaga, N.

    2017-10-01

    By the end of 2016 March, the wide-field Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST) DR4 catalog had accumulated 7681185 spectra (R=1800), of which 6898298 were of stars. We compiled a photometrically confirmed sample of Mira variables from the Kiso Wide-Field Camera (KWFC) Intensive Survey of the Galactic Plane (KISOGP; Matsunaga 2017, arXiv:1705.08567), the American Association of Variable Star Observers (AAVSO) International Database Variable Star Index (VSX; Watson 2006, B/vsx, version 2017-05-02; we selected stars of variability type "M"), and the SIMBAD Astronomical Database. We first cross-matched the KISOGP and VSX Miras with the LAMOST DR4 catalog. Finally, we cross-matched the DR4 catalog with the SIMBAD database. See section 2. (1 data file).

  13. Evaluation of the Abidjan lagoon pollution BRITON BI, G H; *YAO, B ...

    African Journals Online (AJOL)

    MICHAEL

    ABSTRACT: The Abidjan lagoon pollution evaluation via the physicochemical and biochemical characteristics of effluents pouring in it, in order to take decision concerning the installation of a treatment station was reported. All samples of effluents studied contain high quantity of organic and mineral pollutants except for.

  14. 1723-IJBCS-Article- Akoua Kouassi Yao Philomène

    African Journals Online (AJOL)

    hp

    (Zanthoxylum americanum). Phytother. Res., 15(5): 441-443. Leitao D-CEV, De Oliveira CMC. 2001. Two amides from Piper tuberculatum fruits. Fitoterapia, 72: 197-199. Maclean DB, Gracey DEF, Saunders JK,. Rodrigo R, Manske RHF. 1969. Some benzophenanthridine alkaloids from. Bocconia arborea. Can. J. Chem., 47 ...

  15. Medicinal plant knowledge and its erosion among the Mien (Yao) in northern Thailand.

    Science.gov (United States)

    Srithi, Kamonnate; Balslev, Henrik; Wangpakapattanawong, Prasit; Srisanga, Prachaya; Trisonthi, Chusie

    2009-06-22

    We studied local knowledge and actual uses of medicinal plants among the Mien in northern Thailand, documenting traditional medical practices and its transfer between generations. With the assumption that discrepancies between knowledge and actual use represent knowledge erosion, we studied whether actual use of medicinal plants corresponded to people's knowledge of such uses. We used local knowledge from four specialist informants as the domain for semi-structured interviews with 34 randomly selected non-specialist informants. We calculated informant consensus, use value, and fidelity level for each species and use category and performed statistical analyses with Kolmogorov-Smirnov tests, Pearson correlation coefficient, Spearman's rank correlation coefficient, and paired-sample t-tests. We found significant discrepancies between knowledge and actual use of medicinal plants. The number of known and actually used plants increased with increasing informant age and decreased with increasing years of formal education. Medicinal plant knowledge and use in these Mien communities is undergoing inter-generational erosion because of acculturation and interrupted knowledge transmission. Preservation of Mien medicinal plant intellectual heritage requires continued documentation concerning use, conservation, and sustainable management of this resource, which should be publicized to younger Mien.

  16. Therapeutic effect of He-Wei-Tong-Xie decoction on acute ...

    African Journals Online (AJOL)

    Gastrointestinal function scores (stomach ache, abdominal distension, borborygmus and defecation), and ..... and erosion of digestive tract mucosa, resulting in the damage of ... and reproduction in any medium, provided the original work is ...

  17. Calculation of the Instream Ecological Flow of the Wei River Based on Hydrological Variation

    Directory of Open Access Journals (Sweden)

    Shengzhi Huang

    2014-01-01

    Full Text Available It is of great significance for the watershed management department to reasonably allocate water resources and ensure the sustainable development of river ecosystems. The greatly important issue is to accurately calculate instream ecological flow. In order to precisely compute instream ecological flow, flow variation is taken into account in this study. Moreover, the heuristic segmentation algorithm that is suitable to detect the mutation points of flow series is employed to identify the change points. Besides, based on the law of tolerance and ecological adaptation theory, the maximum instream ecological flow is calculated, which is the highest frequency of the monthly flow based on the GEV distribution and very suitable for healthy development of the river ecosystems. Furthermore, in order to guarantee the sustainable development of river ecosystems under some bad circumstances, minimum instream ecological flow is calculated by a modified Tennant method which is improved by replacing the average flow with the highest frequency of flow. Since the modified Tennant method is more suitable to reflect the law of flow, it has physical significance, and the calculation results are more reasonable.

  18. Wei et al., Afr J Tradit Complement Altern Med. (2014) 11(3):70-75

    African Journals Online (AJOL)

    cadewumi

    Extraction methods for volatiles include solvent extraction, steam distillation, pressing, ... These methods generally need organic solvent and have long time for .... Chemical compositions of the essential oils reported in Lysimachia genus were ...

  19. Water use patterns and conservation in households of Wei River Basin, China

    NARCIS (Netherlands)

    Fan, L.; Liu, G.; Wang, F.; Geissen, V.; Ritsema, C.J.

    2013-01-01

    Fully understanding patterns of water use and water conservation among different consumer groups will help in implementing more effective water conservation programs worldwide. Consequently, we investigated water use patterns, water conservation practices, attitudes, and hindrances to water

  20. Peter Paul Rubens, Galileo Galilei und die Schlacht am Weißen Berg

    Czech Academy of Sciences Publication Activity Database

    Konečný, Lubomír

    2005-01-01

    Roč. 26, č. 52 (2005), s. 85-91 ISSN 0391-9064 Institutional research plan: CEZ:AV0Z80330511 Keywords : Peter Paul Rubens * Galileo Galilei * moon Subject RIV: AL - Art, Architecture, Cultural Heritage

  1. Analysis of Hα(Dα) Line Shape Xu Wei & Li Yan

    Indian Academy of Sciences (India)

    Abstract. The particles energy distribution is derived directly from the Hα(Dα) line shape, which is measured by two sets of OMA. The dissociative excitation of molecular is dominating when the local elec- tron temperature is >10eV. The Dα line shape is also simulated by the Monte–Carlo method, the molecular dissociation ...

  2. Implementation of Organizational Changes in Chinese Companies / Wei Sun, Ruth Alas

    Index Scriptorium Estoniae

    Sun, Wei

    2007-01-01

    Põhja-Hiina 160 ettevõttes läbi viidud uuringu alusel analüüsitakse organisatsioonilisi muutusi, nende mõju ja vastumõju, taustaks institutsionaliseerumise olulised etapid Hiina ajaloos. Lisa: Tabelid

  3. Wei et al., Afr J Tradit Complement Altern Med. (2015) 12(5):127 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    AstragalosideIV was the active composition of Radix Astragali. ..... Radix Astragali has been used for the treatment of night sweats, deficiency of qi (e.g., fatigue, weakness, and loss of appetite) and diarrhea. ... Cancer Metastasis Rev.

  4. Spectral Lag Evolution among γ-Ray Burst Pulses Lan-Wei Jia1 ...

    Indian Academy of Sciences (India)

    pulses with observations by CGRO/BATSE. No universal spectral lag evolution feature and pulse luminosity-lag relation within a GRB is observed. ... Key words. γ-rays: bursts—spectral lag—GRB pulse. 1. Introduction. It is found that soft photons lag behind the hard photons and is usually seen in long. GRBs (e.g., Norris et ...

  5. Q. Shen1, X. Chen1, Jiyune Yi2, DR Jiang1 & YJ Yun3

    Indian Academy of Sciences (India)

    imately six months to cover the 2-yr pulsation cycle of VX Sgr. We used a special phase referencing ... but the υ = 2 line has relatively few maser features, most of which reside in the. Southern and Northern parts. ... stronger masers of both the lines appear, among which the main features reside in the inner shell and show ...

  6. Reworked crustal of early Paleozoic WuYi Orogen revealed by receiver function data

    Science.gov (United States)

    Wei, Y.; Duan, Y.; Tian, X.; Zhao, Y.

    2017-12-01

    Intraplate orogenic belt, which occurs at the rigid and undeformable plate interiors, is a distinct new type of orogen rather than an interplate or plate marginal orogenic belt, whose deformation occurs exclusively at plate margins. Therefore, intraplate orogenic belts are the most obvious exception to the plate-tectonic paradigm, they are uncommon in Earth's history. The early Paleozoic Wuyi orogen in South China is one of the few examples of intraplate orogen, and is a key to understanding the process of intraplate orogenesis and global early Paleozoic geodynamics. In this study, we select teleseismic records from 45 mobile linear seismic stations deployed in Wuyi Mountain and 58 permanent stations setting in Jiangxi and Fujian provinces, from January 2011 to December 2012, and calculate the crustal thickness and average crustal Vp/Vs ratio using the H-κ stacking method. The main results include the following: 1) the crustal average Poission's ratio shows an increase tendency from land to sea, the interior of Wuyi orogen belt with an low ration less than 0.23, and the coastline with high ration which is up to 0.28, which indicate a very heterogeneous crustal structure and composition in Wuyi orogen and coast belt. 2) the crustal thickness ranges 28-34 km and shows a tendency of thinning from inland to coast in the region of SE China margin, which maight mean the eastern Eurasia lithospheric is extension and thinning induced by the subducted paleo-Pacific slab. To conclusion, we assume that Wuyi orogen experienced upper crustal thickening, lower crust and lithosphere delamination during the early Paleozoic orogeny, and lithosphere extension in Mesozoic. This research is founded by the Natural Science Foundation of China (41174052 and 41604048).

  7. Neuropeptide Y binding sites in rat brain identified with purified neuropeptide Y-I125

    International Nuclear Information System (INIS)

    Walker, M.W.; Miller, R.J.

    1986-01-01

    Neuropeptide Y (NPY) is a widely distributed neuronally localized peptide with 36 amino acids, 5 of which are tyrosines. The authors wished to investigate the properties of specific receptors for NPY. They therefore labeled the tyrosines with I125 using chloramine T and then purified the peptide using HPLC. A single mono-iodinated species of NPY which yielded > 85% specific binding in rat forebrain synaptosomes was selected as the ligand for all subsequent experiments. A time course of binding showed that equilibrium conditions were reached in 60 minutes at 21 0 C. Scatchard plots revealed a single class of binding sites with a Kd and a Bmax of 3 x 10-10 M and 28 pmol/mg, respectively. Competition binding with unlabeled NPY showed 50% displacement of bound ligand at 1 x 10-10 M NPY. Competition binding with rat pancreatic polypeptide (RPP), a homologous peptide possessing little NPY-like activity, showed 50% displacement of bound ligand at 2 x 10 -7 M RPP. No binding was observed on F-11 or PC12 neuronal cell lines, or on HSWP fibroblast cells. They conclude that NPY-I125 purified to homogeneity with HPLC is a highly selective ligand for NPY receptor sites. They are currently investigating such sites in brain, gut, and other tissues

  8. Computational Thermodynamics of Materials Zi-Kui Liu and Yi Wang

    Energy Technology Data Exchange (ETDEWEB)

    Devanathan, Ram

    2017-02-01

    This authoritative volume introduces the reader to computational thermodynamics and the use of this approach to the design of material properties by tailoring the chemical composition. The text covers applications of this approach, introduces the relevant computational codes, and offers exercises at the end of each chapter. The book has nine chapters and two appendices that provide background material on computer codes. Chapter 1 covers the first and second laws of thermodynamics, introduces the spinodal as the limit of stability, and presents the Gibbs-Duhem equation. Chapter 2 focuses on the Gibbs energy function. Starting with a homogeneous system with a single phase, the authors proceed to phases with variable compositions, and polymer blends. The discussion includes the contributions of external electric and magnetic fields to the Gibbs energy. Chapter 3 deals with phase equilibria in heterogeneous systems, the Gibbs phase rule, and phase diagrams. Chapter 4 briefly covers experimental measurements of thermodynamic properties used as input for thermodynamic modeling by Calculation of Phase Diagrams (CALPHAD). Chapter 5 discusses the use of density functional theory to obtain thermochemical data and fill gaps where experimental data is missing. The reader is introduced to the Vienna Ab Initio Simulation Package (VASP) for density functional theory and the YPHON code for phonon calculations. Chapter 6 introduces the modeling of Gibbs energy of phases with the CALPHAD method. Chapter 7 deals with chemical reactions and the Ellingham diagram for metal-oxide systems and presents the calculation of the maximum reaction rate from equilibrium thermodynamics. Chapter 8 is devoted to electrochemical reactions and Pourbaix diagrams with application examples. Chapter 9 concludes this volume with the application of a model of multiple microstates to Ce and Fe3Pt. CALPHAD modeling is briefly discussed in the context of genomics of materials. The book introduces basic thermodynamic concepts clearly and directs readers to appropriate references for advanced concepts and details of software implementation. The list of references is quite comprehensive. The authors make liberal use of diagrams to illustrate key concepts. The two Appendices at the end discuss software requirements and the file structure, and present templates for special quasi-random structures. There is also a link to download pre-compiled binary files of the YPHON code for Linux or Microsoft Windows systems. The exercises at the end of the chapters assume that the reader has access to VASP, which is not freeware. Readers without access to this code can work on a limited number of exercises. However, results from other first principles codes can be organized in the YPHON format as explained in the Appendix. This book will serve as an excellent reference on computational thermodynamics and the exercises provided at the end of each chapter make it valuable as a graduate level textbook. Reviewer: Ram Devanathan is Acting Director of Earth Systems Science Division, Pacific Northwest National Laboratory, USA.

  9. Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan.

    Science.gov (United States)

    Chen, Fang-Pey; Kung, Yen-Ying; Chen, Yu-Chun; Jong, Maw-Shiou; Chen, Tzeng-Ji; Chen, Fun-Jou; Hwang, Shinn-Jang

    2008-04-17

    Chinese herbal medicine (CHM) has been commonly used in treating liver diseases in Asian countries. To conduct a large-scale pharmacoepidemiological study and evaluate the frequency and pattern of CHM prescriptions in treating chronic hepatitis. We obtained the database of traditional Chinese medicine outpatient claims from the national health insurance in Taiwan for the whole 2002. Patients with chronic hepatitis were identified by the corresponding diagnosis of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and association rule were applied to evaluate the co-prescription of CHM in treating chronic hepatitis. Among the 91,080 subjects treated by CHM for chronic hepatitis, the peak age was in the 40 s, followed by 30 s and 50 s. Male/female ratio was 2.07:1. Long-dan-xie-gan-tang and Saliva miltiorrhiza (Dan-shen) were the most commonly prescribed Chinese herbal formula and single herbal drug, respectively. The most common two-drug prescription was Jia-wei-xia-yao-san plus Saliva miltiorrhiza, and the most common three-drug prescription was Jia-wei-xia-yao-san plus Saliva miltiorrhiza and Artemisia capillaries (Yin-chen-hao). This study showed the utilization pattern of Chinese herbal drugs or formulae in treating chronic hepatitis. Further researches and clinical trials are needed to evaluate the efficacy of these Chinese herbs or its ingredients in treating chronic hepatitis.

  10. Behaviors Related to Mosquito-Borne Diseases among Different Ethnic Minority Groups along the China-Laos Border Areas.

    Science.gov (United States)

    Wu, Chao; Guo, Xiaofang; Zhao, Jun; Lv, Quan; Li, Hongbin; McNeil, Edward B; Chongsuvivatwong, Virasakdi; Zhou, Hongning

    2017-10-15

    Background : In China, mosquito-borne diseases are most common in the sub-tropical area of Yunnan province. The objective of this study was to examine behaviors related to mosquito-borne diseases in different ethnic minority groups and different socioeconomic groups of people living in this region. Methods : A stratified two-stage cluster sampling technique with probability proportional to size was used in Mengla County, Xishuangbanna Prefecture, Yunnan. Twelve villages were used to recruit adult (≥18 years old) and eight schools were used for children (related to mosquito-borne diseases was devised. Results : Multiple correspondence analysis (MCA) grouped 20 behaviors into three domains, namely, environmental condition, bed net use behaviors, and repellent use behaviors, respectively. The Han ethnicity had the lowest odds of rearing pigs, their odds being significantly lower than those of Yi and Yao. For bed net use, Dai and other ethnic minority groups were less likely to use bed nets compared to Yi and Yao. The odds of repellent use in the Han ethnicity was lower than in Yi, but higher than in Dai. The Dai group was the most likely ethnicity to use repellents. Farmers were at a higher risk for pig rearing and not using repellents. Education of less than primary school held the lowest odds of pig rearing. Those with low income were at a higher risk for not using bed nets and repellent except in pig rearing. Those with a small family size were at a lower risk for pig rearing. Conclusion : Different ethnic and socioeconomic groups in the study areas require different specific emphases for the prevention of mosquito-borne diseases.

  11. Behaviors Related to Mosquito-Borne Diseases among Different Ethnic Minority Groups along the China-Laos Border Areas

    Directory of Open Access Journals (Sweden)

    Chao Wu

    2017-10-01

    Full Text Available Background: In China, mosquito-borne diseases are most common in the sub-tropical area of Yunnan province. The objective of this study was to examine behaviors related to mosquito-borne diseases in different ethnic minority groups and different socioeconomic groups of people living in this region. Methods: A stratified two-stage cluster sampling technique with probability proportional to size was used in Mengla County, Xishuangbanna Prefecture, Yunnan. Twelve villages were used to recruit adult (≥18 years old and eight schools were used for children (<18 years old. A questionnaire on behaviors and environment variables related to mosquito-borne diseases was devised. Results: Multiple correspondence analysis (MCA grouped 20 behaviors into three domains, namely, environmental condition, bed net use behaviors, and repellent use behaviors, respectively. The Han ethnicity had the lowest odds of rearing pigs, their odds being significantly lower than those of Yi and Yao. For bed net use, Dai and other ethnic minority groups were less likely to use bed nets compared to Yi and Yao. The odds of repellent use in the Han ethnicity was lower than in Yi, but higher than in Dai. The Dai group was the most likely ethnicity to use repellents. Farmers were at a higher risk for pig rearing and not using repellents. Education of less than primary school held the lowest odds of pig rearing. Those with low income were at a higher risk for not using bed nets and repellent except in pig rearing. Those with a small family size were at a lower risk for pig rearing. Conclusion: Different ethnic and socioeconomic groups in the study areas require different specific emphases for the prevention of mosquito-borne diseases.

  12. Power, identity and antiquarian approaches in modern Chinese art

    OpenAIRE

    Yang, Chia-Ling

    2014-01-01

    The pursuit of antiquity was important for scholarly artists in constructing their knowledge of history and cultural identity in late Imperial China. Following various publications by Bi Yuan 畢沅 (1730-1797), Wu Yi 武億 (1745-1799) and Qian Daxin 錢大昕 (1728-1804) in the 18th century, the study and collecting of rubbings of Northern Wei stone inscriptions and steles was popular. Such spread of interest in jinshi, inscriptions on metal and stone, also formed a base for studying seal carving, epigra...

  13. Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells

    OpenAIRE

    Lee HC; Ling QD; Yu WC; Hung CM; Kao TC; Huang YW; Higuchi A

    2013-01-01

    Hsin-chung Lee,1,2 Qing-Dong Ling,1,3 Wan-Chun Yu,4 Chunh-Ming Hung,4 Ta-Chun Kao,4 Yi-Wei Huang,4 Akon Higuchi3–51Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taoyuan, 2Department of Surgery, Cathay General Hospital, Da'an District, Taipei, 3Cathay Medical Research Institute, Cathay General Hospital, Hsi-Chi City, Taipei, 4Department of Chemical and Materials Engineering, National Central University, Jhongli, Taoyuan, Taiwa...

  14. Sustained release of bactericidal concentrations of penicillin in the pleural space via an antibiotic-eluting pigtail catheter coated with electrospun nanofibers: results from in vivo and in vitro studies

    OpenAIRE

    Chao, Yin-Kai; Lee, Cheng-Hung; Liu, Kuo-Sheng; Wang, Yi-Chuan; Wang, Chih-Wei; Liu, Shih-Jung

    2015-01-01

    Yin-Kai Chao,1 Cheng-Hung Lee,2 Kuo-Sheng Liu,1 Yi-Chuan Wang,3 Chih-Wei Wang,4 Shih-Jung Liu3 1Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital-Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 2Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan; 4Department of P...

  15. Subtype classification for prediction of prognosis of breast cancer from a biomarker panel: correlations and indications

    Directory of Open Access Journals (Sweden)

    Chen C

    2014-02-01

    Full Text Available Chuang Chen,1 Jing-Ping Yuan,2,3 Wen Wei,1 Yi Tu,1 Feng Yao,1 Xue-Qin Yang,4 Jin-Zhong Sun,1 Sheng-Rong Sun,1 Yan Li2 1Department of Breast and Thyroid Surgery, Wuhan University, Renmin Hospital, Wuhan, 2Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 3Department of Pathology, The Central Hospital of Wuhan, Wuhan, 4Medical School of Jingchu University of Technology, Jingmen, People’s Republic of China Background: Hormone receptors, including the estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2 (HER2, and other biomarkers like Ki67, epidermal growth factor receptor (EGFR, also known as HER1, the androgen receptor, and p53, are key molecules in breast cancer. This study evaluated the relationship between HER2 and hormone receptors and explored the additional prognostic value of Ki67, EGFR, the androgen receptor, and p53. Methods: Quantitative determination of HER2 and EGFR was performed in 240 invasive breast cancer tissue microarray specimens using quantum dot (QD-based nanotechnology. We identified two subtypes of HER2, ie, high total HER2 load (HTH2 and low total HER2 load (LTH2, and three subtypes of hormone receptor, ie, high hormone receptor (HHR, low hormone receptor (LHR, and no hormone receptor (NHR. Therefore, breast cancer patients could be divided into five subtypes according to HER2 and hormone receptor status. Ki67, p53, and the androgen receptor were determined by traditional immunohistochemistry techniques. The relationship between hormone receptors and HER2 was investigated and the additional value of Ki67, EGFR, the androgen receptor, and p53 for prediction of 5-year disease-free survival was assessed. Results: In all patients, quantitative determination showed a statistically significant (P<0.001 negative correlation between HER2 and the hormone receptors and a significant

  16. A rare life-threatening disease: unilateral kidney compressed by huge chronic spontaneous retroperitoneal hemorrhage

    Directory of Open Access Journals (Sweden)

    Lu HY

    2018-03-01

    Full Text Available Hao-Yuan Lu,1,* Wei Wei,2,* Qi-Wei Chen,1,* Qing-Gui Meng,1 Gao-Hua Hu,1 Xian-Lin Yi,1,3 Xian-Zhong Bai1 1Department of Urology, Tumor Hospital of Guangxi Medical University and Guangxi Cancer Research Institute, Nanning 530021, China; 2Department of Radiology, Tumor Hospital of Guangxi Medical University and Guangxi Cancer Research Institute, Nanning 530021,China; 3Hubei Engineering Laboratory for Synthetic Microbiology, Wuhan Institute of Biotechnology, Wuhan 430075, China *These authors contributed equally to this work Objectives: To study an uncommon life-threatening disease, spontaneous retroperitoneal and perirenal hemorrhage. Case descriptions: A 69-year-old male presented with pain in the left waist and back of 1 month duration. The renal abscess was suspected by magnetic resonance imaging before operation. The perirenal hematoma was cleaned by operation. In another case, the patient had a functional solitary left kidney compressed by a huge retroperitoneal mass and uropenia appeared. Results: The first patient died of adult respiratory distress syndrome after surgery. The second patient died of cardiac insufficiency and pulmonary embolism on the second day after evacuation of retroperitoneal hematoma. Conclusion: Conservative surgery, such as selective arterial embolization, is a reasonable approach in patients with chronic spontaneous retroperitoneal and perirenal space hemorrhage and with poor general condition. We strongly recommend drainage or interventional therapy, but not a major surgery, in patients with poor condition. Keywords: kidney, spontaneous, retroperitoneal, hemorrhage, surgery

  17. Review: Anja Weiß (2001). Rassismus wider Willen. Ein anderer Blick auf eine Struktur sozialer Ungleichheit

    OpenAIRE

    Bremer, Helmut

    2002-01-01

    Die Arbeit liefert einen Beitrag zur Debatte um Rassismus und Interkulturalität sowie zur Anwendung qualitativer Forschungsverfahren im Rahmen der Theorie BOURDIEUs. Rassismus und Anti-Rassismus werden nicht isoliert betrachtet, sondern als eine Dimension sozialer Ungleichheit, die in eine umfassende Theorie sozialer Ungleichheit eingebunden werden muss. Vorgeschlagen wird BOURDIEUs Konzept von Habitus, Feld und Kapital. Das ermöglicht einen anderen Blick auf das Phänomen. Rassismus reproduzi...

  18. The effects of land use change and precipitation change on direct runoff in Wei River watershed, China.

    Science.gov (United States)

    Dong, Leihua; Xiong, Lihua; Lall, Upmanu; Wang, Jiwu

    2015-01-01

    The principles and degrees to which land use change and climate change affect direct runoff generation are distinctive. In this paper, based on the MODIS data of land use in 1992 and 2003, the impacts of land use and climate change are explored using the Soil Conservation Service Curve Number (SCS-CN) method under two defined scenarios. In the first scenario, the precipitation is assumed to be constant, and thus the consequence of land use change could be evaluated. In the second scenario, the condition of land use is assumed to be constant, so the influence only induced by climate change could be assessed. Combining the conclusions of two scenarios, the effects of land use and climate change on direct runoff volume can be separated. At last, it is concluded: for the study basin, the land use types which have the greatest effect on direct runoff generation are agricultural land and water body. For the big sub basins, the effect of land use change is generally larger than that of climate change; for middle and small sub basins, most of them suffer more from land use change than from climate change.

  19. Doğru Bilgi, Sanal Gerçeklik, İyi Kütüphanecilik

    Directory of Open Access Journals (Sweden)

    M. Tayfun Gülle

    2013-11-01

    Full Text Available Departing from the idea that internet, which has become a deep information tunnel, is causing a problem in access to “accurate information”, it is expressed that societies are imprisoned within the world of “virtual reality” with web 2.0/web 3.0 technologies and social media applications. In order to diagnose this problem correctly, the media used from past to present for accessing information are explained shortly as “social tools.” Furthermore, it is emphasised and summarised with an editorial viewpoint that the means of reaching accurate information can be increased via the freedom of expression channel which will be brought forth by “good librarianship” applications. IFLA Principles of Freedom of Expression and Good Librarianship is referred to at the end of the editorial.

  20. IFLA- Ülkelerin En İyi On Resimli Çocuk Kitapları Listesi Projesi

    Directory of Open Access Journals (Sweden)

    Muhittin Gürbüz

    2014-03-01

    Full Text Available IFLA Çocuklar ve Genç Yetişkinler Bölümü, her ülkenin kütüphanecileri tarafından belirlenen en iyi on resimli kitap, The World Through Picture Books1 projesini 2011 yılında başlatmış bulunmaktadır. Şimdiye kadar 36 ülkenin yer aldığı projeye, Türkiye 37. ülke olarak katılmıştır. Proje çerçevesinde, Türkiye’deki tüm kütüphaneciler tarafından, elektronik oylama yöntemiyle en iyi on resimli çocuk kitabı seçilmiştir. Bu makalede, projenin yayınlanan elektronik kataloğundan yararlanılarak, proje hakkında bilgi verilmekte ve Türkiye için hazırlanan en iyi on resimli kitap projesi tanıtılmaktadır.

  1. Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell Contractility

    Science.gov (United States)

    Yeh, Yi-Chun; Cheng, Chi-Fung; Shiao, Yi-Tzone; Wang, Chang-Bi; Chien, Wen-Kuei; Chen, Jin-Hua; Liu, Xiang; Tsang, Hsinyi; Lin, Ting-Hsu; Liao, Chiu-Chu; Huang, Shao-Mei; Li, Ju-Pi; Lin, Cheng-Wen; Pang, Hao-Yu; Lin, Jaung-Geng; Lan, Yu-Ching; Liu, Yu-Huei; Chen, Shih-Yin; Tsai, Fuu-Jen; Liang, Wen-Miin

    2015-01-01

    Type 2 diabetes (T2D) is a chronic, multifactorial, and metabolic disorder accounting for 90% diabetes cases worldwide. Among them, almost half of T2D have hypertension, which is responsible for cardiovascular disease, morbidity, and mortality in these patients. The Chinese herbal medicine (CHM) prescription patterns of hypertension individuals among T2D patients have yet to be characterized. This study, therefore, aimed to determine their prescription patterns and evaluate the CHM effect. A cohort of one million randomly sampled cases from the National Health Insurance Research Database (NHIRD) was used to investigate the overall survival rate of CHM users, and prescription patterns. After matching CHM and non-CHM users for age, gender and date of diagnosis of hypertension, 980 subjects for each group were selected. The CHM users were characterized with slightly longer duration time from diabetes to hypertension, and more cases for hyperlipidaemia. The cumulative survival probabilities were higher in CHM users than in non-CHM users. Among these top 12 herbs, Liu-Wei-Di-Huang-Wan, Jia-Wei-Xiao-Yao-San, Dan-Shen, and Ge-Gen were the most common herbs and inhibited in vitro smooth muscle cell contractility. Our study also provides a CHM comprehensive list that may be useful in future investigation of the safety and efficacy for individuals with hypertension among type 2 diabetes patients. PMID:26699542

  2. Neuroprotection of lamotrigine on hypoxic-ischemic brain damage in neonatal rats: Relations to administration time and doses

    Directory of Open Access Journals (Sweden)

    Yong-Hong Yi

    2008-06-01

    Full Text Available Yong-Hong Yi1, Wen-Chao Guo1, Wei-Wen Sun1, Tao Su1, Han Lin1, Sheng-Qiang Chen1, Wen-Yi Deng1, Wei Zhou2, Wei-Ping Liao11Department of Neurology, Institute of Neurosciences and the Second Affiliated Hospital, 2Department of Neonatology, Affiliated Guangzhou Children’s Hospital, Guangzhou Medical College, Guangzhou, Guangdong Province, P.R. ChinaAbstract: Lamotrigine (LTG, an antiepileptic drug, has been shown to be able to improve cerebral ischemic damage by limiting the presynaptic release of glutamate. The present study investigated further the neuroprotective effect of LTG on hypoxic-ischemic brain damage (HIBD in neonatal rats and its relations to administration time and doses. The HIBD model was produced in 7-days old SD rats by left common carotid artery ligation followed by 2 h hypoxic exposure (8% oxygen. LTG was administered intraperitoneally with the doses of 5, 10, 20, and 40 mg/kg 3 h after operation and the dose of 20 mg/kg 1 h before and 3 h, 6 h after operation. Blood and brain were sampled 24 h after operation. Nissl staining, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL, and neuron-specific enolase (NSE immunohistochemical staining were used for morphological studies. Water content in left cortex and NSE concentration in serum were determined. LTG significantly reduced water content in the cerebral cortex, as well as the number of TUNEL staining neurons in the dentate gyrus and cortex in hypoxic-ischemia (HI model. Furthermore, LTG significantly decreased the NSE level in serum and increased the number of NSE staining neurons in the cortex. These effects, except that on water content, were dose-dependent and were more remarkable in the pre-treated group than in the post-treated groups. These results demonstrate that LTG may have a neuroprotective effect on acute HIBD in neonates. The effect is more prominent when administrated with higher doses and before HI.Keywords: hypoxic-ischemic brain

  3. Korrekte Entscheidungen in Kenntnis der Sachlage? Anmerkungen zum Verbraucherbild im Weißbuch zur Lebensmittelsicherheit der Kommission der Europäischen Gemeinschaften

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2000-01-01

    Lebensmittels vorrangig aufgrund eigener Erfahrungen: sie interpretieren Informationen über Produkte oft falsch. Der Autor schließt darus, daß erweiterte Kennzeichungsvorschriften die Qualität der Verbraucher-Entscheidungen kaum verbessern können. Statt dessen sollten Informationen vereinfacht und gebündelt...

  4. 北魏前期汉族士人的社会交往初探%On the Social Interaction of Han Scholars in the Early Northern Wei Dynasty

    Institute of Scientific and Technical Information of China (English)

    杨龙

    2012-01-01

    Under the background of aristocracy of medieval China, social interaction among scholars are very important for them to maintain and promote their political status. The scholars of Han nationality tried to construct the mutual identity between themselves and to gain effective political resources by establishing social network though they had been restricted politically. They also paid much attention to rural community which laid the foundation of their social communication. When more and more Han scholars secured official positions in Pingcheng (平城) , this city became the center of their social interaction. There were two different pattern of social networks, one was headed by Cui Hao (崔浩), and the other was the social network of Han scholars of the region of Qing and Qi area (青齐). However, the social interaction among the Han scholars tends to be involved politically, which suggests that social communication among them are not very deep and active under the political pressure, but has a certain scale.%在中国中古门阀政治的背景下,士人之间的社会交往对于维护和提升其政治地位具有重要作用。北魏前期的汉族士人虽然在政治上受到较大的限制,但他们仍然试图在现有政治状况之下,通过社会交往建立社会网络,从而形成相互间的身份认同并获得有效的政治资源。乡里社会是汉族士人展开社会交往的基础,他们也十分重视。随着仕宦于平城的汉族士人逐渐增多,平城就成了北魏前期汉族士人社会交往的中心。以崔浩为中心的社交网络和青齐地区的汉族士人的交往成了这一时期较为明显的两种社会交往形态。当然,汉族士人之间的社会交往往往受到政治的牵连。

  5. Factors affecting domestic water consumption in rural households upon access to improved water supply: insights from the Wei River Basin, China

    NARCIS (Netherlands)

    Fan, L.; Liu, G.; Wang, F.; Geissen, V.; Ritsema, C.J.

    2013-01-01

    Comprehensively understanding water consumption behavior is necessary to design efficient and effective water use strategies. Despite global efforts to identify the factors that affect domestic water consumption, those related to domestic water use in rural regions have not been sufficiently

  6. Occurrence of chai hu (Bupleuri radix) in prescriptions of Chinese herbal medicine in Switzerland.

    Science.gov (United States)

    Klein, Sabine D; Becker, Simon; Wolf, Ursula

    2012-01-01

    Chai hu (Bupleuri radix), one of the most frequently used herbs in Chinese herbal medicine, has 3 major functions, depending on dosage and combination with other herbs. The aim of this study was to investigate how chai hu is prescribed in everyday practice in Switzerland, and whether these prescription patterns reflect its various applications. A random sample of 1,053 prescriptions was drawn from the database of Lian Chinaherb AG, Wollerau, Switzerland, and analyzed regarding the most frequently used classical formulas containing chai hu, daily dosages and combinations with other herbs. 29.0% of all prescriptions contained chai hu, and 98.0% of these were in granular form. The most frequently used classical formulas were xiao yao san ('rambling powder'), jia wei xiao yao san ('augmented rambling powder') and chai hu shu gan san ('Bupleurum powder to spread the liver'). In more than half of the prescriptions, chai hu was combined with bai shao (Paeoniae Radix Alba), dang gui (Angelicae sinensis radix) or fu ling (Poria). 51.8% of the prescriptions contained a low daily dosage of chai hu, 24.9% a medium and 15.1% a high dosage. Chai hu was generally prescribed in classic combinations with other herbs and in a medium dosage. Due to the addition of supplementary herbs to classical formulas, its daily dose was often diminished from a high or medium dose to a low dose. This raises the question if chai hu would then still exert its desired function of, e.g., moving liver-qi in these prescriptions.

  7. 圖書館事業與交流/Location Choice Patterns of Computer Use in the United States/Zhixian Yi; Philip Q. Yang

    Directory of Open Access Journals (Sweden)

    Zhixian Yi; Philip Q. Yang Zhixian Yi; Philip Q. Yang

    2009-10-01

    Full Text Available There is little research on the patterns of computer use outside home or work. This study examines who is more or less likely to use a computer at a location other than work or home by using the 2002–2004 General Social Survey data and logistic regression analysis. Demographic variables (such as age, race, marital status, and region, socioeconomic status (such as education and family income, self employment, and satisfaction with financial situation are significant predictors of computer use at locations other than home or work; but occupation and gender make no difference. The findings will help institutions to provide computer infrastructure support and services for customers in public places, and especially help schools and libraries to improve computer labs and services. 過去在探討非居家或上班電腦使用地點的研究微之又微。本文針對2002-2004 年總體社會調查資料進行對數回歸分析,分析更可能或不可能在家外或工作外使用電腦的族群。研究結果顯示,人口變量如年齡、種族、婚姻狀況、地區,社經地位(教育程度、家庭收入),是否自謀職業,是否對財政狀況滿意等,為解釋是否在家外或工作外使用電腦的有效自變量,然而職業和性別的影響則不顯著。本研究結果對於社會機構在公共場所提供計算機基礎設施和服務,以及對學校和圖書館改善電腦使用室及服務具有參考價值。 頁次:116-130

  8. En İyi İçerik Pazarlama: THY’den Örnekler = Best Content Marketing Cases From Turkish Airlines

    OpenAIRE

    Durceylan, Ayşe Nur

    2016-01-01

    Ayşe Nur Durceylan; Üretim Yönetimi ve Pazarlama eğitiminden sonra, Pazarlama üzerine yükseklisans yapan Durceylan, Turkcell ve Eti'de stajını tamamlamasının ardından Türk Hava Yolları'nda Performans ve İş Geliştirme alanında uzman olarak çalışmaya başlamıştır. 2 yıllık bu deneyiminin ardından, 2012 başında THY'de İnteraktif Pazarlama ve İletişim Müdürlüğü'nde Uzman olarak iş hayatına devam etmeye başlayan Durceylan halen bu görevini devam ettirmektedir. Şu anda Asya ve Uzakdoğu bölgesinde s...

  9. Accurate Information, Virtual Reality, Good Librarianship Doğru Bilgi, Sanal Gerçeklik, İyi Kütüphanecilik

    Directory of Open Access Journals (Sweden)

    M. Tayfun Gülle

    2010-03-01

    Full Text Available Departing from the idea that internet, which has become a deep information tunnel, is causing a problem in access to “accurate information”, it is expressed that societies are imprisoned within the world of “virtual reality” with web 2.0/web 3.0 technologies and social media applications. In order to diagnose this problem correctly, the media used from past to present for accessing information are explained shortly as “social tools.” Furthermore, it is emphasised and summarised with an editorial viewpoint that the means of reaching accurate information can be increased via the freedom of expression channel which will be brought forth by “good librarianship” applications. IFLA Principles of Freedom of Expression and Good Librarianship is referred to at the end of the editorial.

  10. Reply to Cen LiXiang, Li XinQi, and Yan YiJing: No adiabatic conditional geometrical phase shift

    OpenAIRE

    Xiangbin, Wang

    2002-01-01

    Much long before the appearing time of the Comment by Cen, Li, and Yan,, the main issue addresed there by Cen et al had been resolved already. The information offered by the Comment is selective and misleading.

  11. [Herbal textual research on Chinese medicine "Huangjing" (Polygonati Rhizoma)and some enlightenments].

    Science.gov (United States)

    Liu, Jing-Jing; Si, Jin-Ping

    2018-02-01

    To clarify the change and development of the original plants, medicinal organs, traditional functions, resource distribution of "Huangjing"(Polygonati Rhizome), a traditional Chinese medicine, we investigated Polygonatum species on the ancient Chinese herbal texts. The name of "Nüwei" was first carried out in the book of Sheng Nong's Herbal Classic. Its effects included two aspects: one was similar to "Weirui"(Polygonati Odorati Rhizome, "Yuzhu"), that was tonifying, nourishing one's vitality, removing wind and dampness, settling five organs, making body lightness, keeping longevity and not being hungry; the second was alike to "Huangjing" recorded in the book of Ming Yi Bie Lu(Appendant Records of Famous Physicians). Specifically, "Weirui" possesses the therapeutic effect of "Nüwei", while "Huangjing" possesses the tonic effect of " Nüwei". Thereafter, the following ancient Chinese herbal texts kept those two names and function records. Accordingly, we hold the point of view that "Huangjing" was first carried out in the book of Sheng Nong's Herbal Classic in the synonym of "Nüwei". "Yuzhu" included the "Huangjing" in ancient herbal text before Qing Dynasty, that was further confirmed by the research on change and development of the original plants. The identification between "Yuzhu" and "Huangjing" was based on the shape of rhizome and size before early Tang Dynasty. The shape was a key character and used up to now, but size was not reasonable. The opposite phyllotaxy was an important character of authentic "Huangjing" from Tang to Qing Dynasty. The seedling of Polygonatum sibiricum and P. kingianum, the adult plant of P. cyrtonema with alternate leaves were misused as "Yuzhu"("Nüwei" and "Weirui") at that time. Therefore, both "Yuzhu" and "Huangjing" should be used as key words during the search of ancient prescriptions and development of new drugs and health foods. The leaves, flowers, fruits and seedlings could

  12. Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Yao MY

    2014-09-01

    Full Text Available Minya Yao,1 Yu Liu,1 Hailong Jin,2 Xiaojiao Liu,1 Kezhen Lv,1 Haiyan Wei,1 Chengyong Du,1 Shuqian Wang,1 Bajin Wei,1 Peifen Fu1 1Department of Breast Center, 2Gastrointestinal Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China Abstract: Cancer-associated inflammation is a key determinant of disease progression and survival in most cancers. The aim of our study was to assess the predictive value of preoperative inflammatory markers, such as the neutrophil–lymphocyte ratio (NLR, platelet–lymphocyte ratio, red cell distribution width (RDW, and mean platelet volume, for survival in breast cancer patients. In total, 608 breast cancer patients operated on between January 2009 and December 2011 were included in this observational study. The association between preoperative inflammatory markers and survival outcomes was analyzed. Patients with high NLR (>2.57 or high RDW (>13.45% showed a significantly lower overall survival rate than those with lower NLR (≤2.57 or lower RDW (≤13.45%. NLR and RDW, along with node stage and molecular subtypes, were independent prognostic factors. There was a significant survival difference according to NLR in the luminal A and triple-negative subtypes (93.3% versus 99.3%, P=0.001; 68.8% versus 95.1%, P=0.000, respectively. The triple-negative subtype was the only subtype in which higher RDW patients showed significantly poor prognosis (81.3% versus 95.5%, P=0.025. Pre-operation NLR and RDW is a convenient, easily measured prognostic indicator for patients with breast cancer, especially in patients with the triple-negative subtype. Keywords: neutrophil-to-lymphocyte ratio, NLR, red cell distribution width, RDW, overall survival

  13. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    Science.gov (United States)

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  14. Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin

    Directory of Open Access Journals (Sweden)

    Yao MZ

    2016-11-01

    Full Text Available Meng-Zhu Yao,1 Ming-Yi Huang-Fu,1 Hui-Na Liu,1 Xia-Rong Wang,1 Xiaoxia Sheng,2 Jian-Qing Gao1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 2Hangzhou SoliPharma Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China Abstract: Nano-hydroxyapatite/polyamide 66 (nHA/PA66 porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs and silk fibroin (SF were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs. The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected. In addition, the morphology and mechanical property of the scaffolds were investigated. The results showed that the nHA/PA66 scaffolds modified with CNTs and SF met the requirements of bone tissue engineering scaffolds. The dexamethasone-loaded CNT/SF-nHA/PA66 composite scaffold promoted the osteogenic differentiation of BMSCs, and the drug-loaded scaffolds are expected to function as effective bone tissue engineering scaffolds. Keywords: BMSCs, tissue engineering, porous scaffold, carbon nanotubes, silk fibroin, surface modification, dexamethasone

  15. Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining

    Directory of Open Access Journals (Sweden)

    Chia-Ming Lu

    2013-01-01

    Full Text Available This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.

  16. Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Chronic Hepatitis in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study

    Directory of Open Access Journals (Sweden)

    Kuo-Chin Huang

    2017-01-01

    Full Text Available We conducted a National Health Insurance Research Database-based Taiwanese nationwide population-based cohort study to evaluate whether Chinese herbal medicine (CHM treatment decreased the incidence of chronic hepatitis in breast cancer patients receiving chemotherapy and/or radiotherapy. A total of 81171 patients were diagnosed with breast cancer within the defined study period. After randomly equal matching, data from 13856 patients were analyzed. Hazard ratios of incidence rate of chronic hepatitis were used to determine the influence and therapeutic potential of CHM in patients with breast cancer. The patients with breast cancer receiving CHM treatment exhibited a significantly decreased incidence rate of chronic hepatitis even across the stratification of age, CCI score, and treatments. The cumulative incidence of chronic hepatitis for a period of seven years after initial breast cancer diagnosis was also reduced in the patients receiving CHM treatment. The ten most commonly used single herbs and formulas were effective in protecting liver function in patients with breast cancer, where Hedyotis diffusa and Jia-Wei-Xiao-Yao-San were the most commonly used herbal agents. In conclusion, our study provided information that western medicine therapy combined with CHM as an adjuvant modality may have a significant impact on liver protection in patients with breast cancer.

  17. Is Traditional Chinese medicine effective for reducing hyperthyroidism?

    Science.gov (United States)

    Chang, Cheng-Chieh; Huang, Sheng-Teng

    2010-11-01

    Graves' disease is an autoimmune disease that can affect a few patients with hyperthyroidism. In this case report, we demonstrated that Traditional Chinese Medicine (TCM) was effective for the patient with hyperthyroidism induced by Graves' disease. The patient also remained in the euthyroid state for several years after the treatment. SUBJECT AND SETTING: A 33-year-old woman had palpitations, fatigability, and weight loss and was diagnosed as having Graves' disease. Urticaria and itching skin appeared after she took an antithyroid drug. Therefore, she sought treatment with TCM. After regular therapy with Jia Wei Xiao Yao San in addition to Xia Ku Cao, Bei Mu, and oyster shell, her symptoms subsided and the thyroid function level returned to normal range with 3 years' treatment. She still remained in the euthyroid state for 3 years after discontinuing the TCM treatment up to the present. Neither complications nor side-effects were noted during the TCM treatment. This case demonstrates that TCM is an effective and alternative option for hyperthyroidism induced by Graves' disease, especially for patients who have an allergic reaction caused by thioamides.

  18. Prescription Pattern of Chinese Herbal Products for Breast Cancer in Taiwan: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Jung-Nien Lai

    2012-01-01

    Full Text Available Background. Chinese herbal products (CHPs given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan. Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs for utilization of CHP. Results. 81.5 percent (N=2,236 of women with breast cancer utilized traditional Chinese medicine (TCM and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix and six contained ren shen (Panax ginseng-radix, which are reported to have potential beneficial synergistic effects on breast cancer cells. Conclusion. CHP containing dang qui (Angelica sinensis-radix or ren shen (Panax ginseng-radix are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers.

  19. Promotion of peripheral nerve regeneration of a peptide compound hydrogel scaffold

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    Wei GJ

    2013-08-01

    Full Text Available Guo-Jun Wei,1 Meng Yao,1 Yan-Song Wang,1 Chang-Wei Zhou,1 De-Yu Wan,1 Peng-Zhen Lei,1 Jian Wen,1 Hong-Wei Lei,2 Da-Ming Dong1 1Department of Orthopaedics, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China; 2Department of Rheumatology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China Background: Peripheral nerve injury is a common trauma, but presents a significant challenge to the clinic. Silk-based materials have recently become an important biomaterial for tissue engineering applications due to silk’s biocompatibility and impressive mechanical and degradative properties. In the present study, a silk fibroin peptide (SF16 was designed and used as a component of the hydrogel scaffold for the repair of peripheral nerve injury. Methods: The SF16 peptide’s structure was characterized using spectrophotometry and atomic force microscopy, and the SF16 hydrogel was analyzed using scanning electron microscopy. The effects of the SF16 hydrogel on the viability and growth of live cells was first assessed in vitro, on PC12 cells. The in vivo test model involved the repair of a nerve gap with tubular nerve guides, through which it was possible to identify if the SF16 hydrogel would have the potential to enhance nerve regeneration. In this model physiological saline was set as the negative control, and collagen as the positive control. Walking track analysis and electrophysiological methods were used to evaluate the functional recovery of the nerve at 4 and 8 weeks after surgery. Results: Analysis of the SF16 peptide’s characteristics indicated that it consisted of a well-defined secondary structure and exhibited self-assembly. Results of scanning electron microscopy showed that the peptide based hydrogel may represent a porous scaffold that is viable for repair of peripheral nerve injury. Analysis of cell culture also supported that the hydrogel was an effective

  20. The Use of Herbal Medicine in Alzheimer's Disease—A Systematic Review

    Directory of Open Access Journals (Sweden)

    Leopoldo Luiz dos Santos-Neto

    2006-01-01

    Full Text Available The treatments of choice in Alzheimer's disease (AD are cholinesterase inhibitors and NMDA-receptor antagonists, although doubts remain about the therapeutic effectiveness of these drugs. Herbal medicine products have been used in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD but with various responses. The objective of this article was to review evidences from controlled studies in order to determine whether herbs can be useful in the treatment of cognitive disorders in the elderly. Randomized controlled studies assessing AD in individuals older than 65 years were identified through searches of MEDLINE, LILACS, Cochrane Library, dissertation Abstract (USA, ADEAR (Alzheimer's Disease Clinical Trials Database, National Research Register, Current Controlled trials, Centerwatch Trials Database and PsychINFO Journal Articles. The search combined the terms Alzheimer disease, dementia, cognition disorders, Herbal, Phytotherapy. The crossover results were evaluated by the Jadad's measurement scale. The systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD: Melissa officinalis, Salvia officinalis and Yi-Gan San and BDW (Ba Wei Di Huang Wan. Ginkgo biloba was identified in a meta-analysis study. All five herbs are useful for cognitive impairment of AD. M. officinalis and Yi-Gan San are also useful in agitation, for they have sedative effects. These herbs and formulations have demonstrated good therapeutic effectiveness but these results need to be compared with those of traditional drugs. Further large multicenter studies should be conducted in order to test the cost-effectiveness of these herbs for AD and the impact in the control of cognitive deterioration.

  1. A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling

    Directory of Open Access Journals (Sweden)

    Jia WX

    2015-04-01

    Full Text Available Wei-Xue Jia,1,2 Xue-Min Xiao,1,2 Jian-Bing Wu,1,2 Yi-Ping Ma,1,2 Yi-Ping Ge,1,2 Qi Li,1,2 Qiu-Xia Mao,1,2 Cheng-Rang Li1,2 1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China; 2Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, China Abstract: Piebaldism is a rare autosomal dominant genodermatosis, manifesting as congenital and stable depigmentation of the skin and white forelock. It has been found to be associated with mutations in the KIT or SLUG genes. We report a Chinese piebaldism family including a 28-year-old woman and her 3-year-old son with characteristics of white patches and forelock associated with numerous brown macules and patches. Genomic DNA samples of the proband and her son were extracted from their peripheral blood. One hundred unrelated healthy individuals were used as controls. All coding regions of KIT, SLUG, and NF1 genes were amplified by polymerase chain reaction using exon flanking intronic primers and Sanger sequencings were performed. DNA sequencing revealed heterozygous missense c.2431T>G mutation in exon 17 of the KIT gene in the proband and the affected son. No potentially pathogenic variant was identified in SLUG or NF1 genes. The nucleotide substitution was not found in 100 unrelated control individuals. This study reveals a novel KIT mutation in piebaldism, and it further supports that café-au-lait macules and intertriginous freckling of piebaldism are parts of pigmented anomaly in piebaldism, which does not necessarily represent coexistence of neurofibromatosis type 1 (NF1. Keywords: novel mutation, KIT gene, neurofibromatosis type 1 

  2. Comparison of the effectiveness and toxicity of neoadjuvant chemotherapy regimens, capecitabine/epirubicin/cyclophosphamide vs 5-fluorouracil/epirubicin/cyclophosphamide, followed by adjuvant, capecitabine/docetaxel vs docetaxel, in patients with operable breast cancer

    Directory of Open Access Journals (Sweden)

    Zhang MM

    2016-06-01

    Full Text Available Minmin Zhang,* Wei Wei,* Jianlun Liu, Huawei Yang, Yi Jiang, Wei Tang, Qiuyun Li, Xiaoming Liao Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China *These authors contributed equally to this work Abstract: The aim of this study was to compare the effectiveness and toxicity of neoadjuvant chemotherapy regimens, xeloda/epirubicin/cyclophosphamide (XEC vs 5-fluorouracil/epirubicin/cyclophosphamide (FEC, followed by adjuvant chemotherapy regimens, capecitabine/taxotere (XT vs taxotere (T, in axillary lymph node (LN-positive early-stage breast cancer. In this randomized, Phase III trial, 137 patients with operable primary breast cancer (T2-0, N0-1 who were tested axillary LN positive through aspiration biopsy of axillary LNs were randomized (1:1 to four 3-weekly cycles of XEC or FEC. Patients underwent surgery within 4–6 weeks after the fourth cycle, followed by four adjuvant cycles of 3-weekly XT or T. The primary end point was tumor pathological complete response. Toxicity profiles were secondary objectives. In total, 131 patients had clinical and radiological evaluation of response and underwent surgery. Treatment with XEC led to an increased rate of pathological complete response in primary tumor (18% vs 6%, respectively, P=0.027 and objective remission rate (87% vs 73%, P=0.048 compared to FEC. Clinical complete response occurred in 20% and 7% for XEC and FEC, respectively. Compared to FEC, XEC was associated with more hand-foot syndrome (57% vs 11%, P<0.001 and 3/4 grade nausea/vomiting/diarrhea (30% vs 14%, P=0.034 but less phlebitis (3% vs 14%, P=0.035. XT and T adjuvant chemotherapy regimens were well tolerated: treatment-related 3/4 grade adverse events occurred in 28% and 17% of patients receiving XT and T, respectively. Keywords: breast cancer, capecitabine, docetaxel, neoadjuvant chemotherapy, curative effect, toxic side effects

  3. On the Level of Performance of Selected Link Functions in the ...

    African Journals Online (AJOL)

    2012-12-01

    Dec 1, 2012 ... the response variable in models to facilitate inference on poverty. The results of the study .... We treat yi as a realization of a random variable Yi. In the general linear model we assume that Yi has a normal distribution with mean µi and variance. 2 σ ,. i.e., Yi ~ N (µi, ... binomial, Poisson, exponential, gamma,.

  4. Acute parietal lobe infarction presenting as Gerstmann’s syndrome and cognitive decline mimicking senile dementia

    Directory of Open Access Journals (Sweden)

    Chen TY

    2013-07-01

    Full Text Available Tien-Yu Chen,1 Chun-Yen Chen,1,3 Che-Hung Yen,2,3 Shin-Chang Kuo,1,3 Yi-Wei Yeh,1,3 Serena Chang,1 San-Yuan Huang1,31Department of Psychiatry, 2Department of Neurology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, 3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaAbstract: Gerstmann’s syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixed anxious-depressive mood. Gerstmann’s syndrome without obvious motor function impairment and dementia-like features could be observed at first. Emergent brain computed tomography scan revealed new left-middle cerebral artery infarction over the left posterior parietal lobe. This case reminds us that acute cerebral infarction involving the parietal lobe may present as Gerstmann’s syndrome accompanied by cognitive decline mimicking dementia. As a result, emergent organic workups should be arranged, especially for elderly patients at high risk for cerebral vascular accident.Keywords: Gerstmann’s syndrome, dementia, parietal lobe infarction

  5. Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan

    Directory of Open Access Journals (Sweden)

    Lin CW

    2015-07-01

    Full Text Available Chun-Wei Lin,1,2 Yih-Yuan Chen,3 Yi-Jen Chen,1,4 Chi-Yen Liang,1 Ming-Shian Lin,1,4 Wei Chen1,5,6 1Division of Pulmonary and Critical Care Medicine, Chia-Yi Christian Hospital, Chia-Yim, 2Division of Chest, Division of Pulmonary Medicine, Kuang Tien General Hospital, Taichung, 3Department of Internal Medicine, Chia-Yi Christian Hospital, 4Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, 5College of Nursing, Dayeh University, 6Department of Respiratory Therapy, China Medical University, Taichung, Taiwan Background: Data regarding osteoporosis in COPD patients in Taiwan remain limited. The primary end point of this study was to evaluate the prevalence and risk factors of osteoporosis in COPD patients in Taiwan. The secondary end point was to examine the association between osteoporosis and health-related quality of life (HRQL in COPD patients.Materials and methods: This prospective cross-sectional study enrolled 125 COPD patients (mean age 73.6 years, forced expiratory volume in 1 second [FEV1] 1.19±0.43 L who had bone mineral-density measurements performed consecutively. Demographic data, lung function, and HRQL including modified Medical Research Council dyspnea scale, St George’s Respiratory Questionnaire, oxygen-cost diagram, Center for Epidemiologic Studies – depression scale, and COPD Assessment Test scores were recorded. Results: A total of 50 (40% participants were diagnosed as having osteoporosis. In a multivariate logistic regression model including age, smoking amount (pack-year, body mass index (BMI, and FEV1, only BMI (odds ratio 0.824, 95% confidence interval 0.73–0.93; P=0.002 and FEV1 (odds ratio 0.360, 95% confidence interval 0.13–0.98; P=0.046 were negatively associated with an increased risk of osteoporosis in COPD patients. In addition, COPD patients with osteoporosis had significantly higher modified Medical Research Council dyspnea scale scores (1.7±0.8 vs 1.4±0.8, P=0

  6. Post vom weißen Tyrannen: Erste kommunikations- und mediengeschichtliche Monographie zu Friedrich Melchior Grimms ‚Correspondance littéraire‘ – Kirill Abrosimovs ‚Aufklärung jenseits der Öffentlichkeit‘

    Directory of Open Access Journals (Sweden)

    Jonas Hock

    2015-07-01

    Full Text Available Kirill Abrosimov, Aufklärung jenseits der Öffentlichkeit: Friedrich Melchior Grimms ‚Correspondance littéraire‘ (1753–1773 zwischen der „république des lettres“ und europäischen Fürstenhöfen (Ostfildern: Thorbecke, 2014.

  7. Review: Anja Weiß (2001). Rassismus wider Willen. Ein anderer Blick auf eine Struktur sozialer Ungleichheit [Racism against Intention. A Different View on a Structure of Social Inequality

    OpenAIRE

    Helmut Bremer

    2002-01-01

    The book contributes to the debate about racism and inter-culturalism as well as to the use of qualitative research methods within the scope of the theory of BOURDIEU. Racism and anti-racism are considered as a specific dimension of social inequality and, therefore, must be connected with a more comprehensive theory of social inequality such as BOURDIEUs concepts of habitus, field and capital. This allows for a different view on the phenomenon. According to this perspective, racism is not onl...

  8. Yinsheng Tian, Kai Gu, and Wei Tao (eds.. Urban Morphology, Architectural Typology and Cities in Transition. 197 p. ISBN: 978-7-03-040218-9. 2014. Science Press, Beijing.

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    Mildred Moreno Villanueva

    2015-08-01

    Full Text Available Como resultado de las reformas económicas que se han venido implementando en China desde 1978, la tasa de urbanización de ese país se ha incrementado desde un 18% a alrededor del 50%. Es decir, que actualmente la población urbana de China (más de 650 millones de personas representa más del doble de la población total de los Estados Unidos. Tomando este proceso como eje, en el libro se presenta el estado del arte de la investigación sobre la forma urbana en ese país en lo que respecta a las ciudades tradicionales, las ciudades tempranas de la modernidad, las ciudades socialistas y del periodo post-reforma, así como la preservación histórica, la conservación, y la investigación sobre tipologías de vivienda tradicional en China.

  9. Ergenlerin Öznel İyi Oluşlarıyla Aile Ortamları Arasındaki İlişkinin İncelenmesi

    OpenAIRE

    ERYILMAZ, Yrd. Doç. Dr. Ali

    2011-01-01

    The Relationship Between Adolescents’ Subjective Well-Being and Family EnvironmentThis study examines the association between family environment and subjective well-being among Turkish adolescents. The participants of the study include a total of 252 adolescents (128 male and 124 female). The ages of them range between 14 and 17. The data of the study were obtained through the use of the Adolescents’ Subjective Well-Being Scale and Family Environment Scale. The data were analyzed through usin...

  10. Beş Faktör Kişilik Özellikleri ve Öznel İyi Oluş = The Five Factor Personality Traits and Subjective Well-Being

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    Tayfun DOĞAN

    2013-01-01

    Full Text Available The aim of this research is to analyze the relations between personality traits and subjective well-being. The number of the participants of the research was 234 (98 women/136 men. The age range of the study group was 18-61. The Oxford Happiness Scale-Short Form and the Big Five Personality Scale were used. Findings showed that there was a significantly negative relationship between neurotic personality trait and subjective well-being. Findings also revealed that there were positive relationships between subjective well-being and extraversion, conscientiousness, agreeableness, openness. Besides, it was found that neurotic personality trait was a negative and extraversion was a positive predictor of subjective well-being.

  11. Screening bioactive quality control markers of QiShenYiQi dripping pills based on the relationship between the ultra-high performance liquid chromatography fingerprint and vascular protective activity.

    Science.gov (United States)

    Zhuo, Limeng; Peng, Jingjing; Zhao, Yunli; Li, Dongxiang; Xie, Xiuman; Tong, Ling; Yu, Zhiguo

    2017-10-01

    Traditional Chinese medicine consists of complex phytochemical constituents. Selecting appropriate analytical markers of traditional Chinese medicine is a critical step in quality control. Currently, the combination of fingerprinting and efficacy evaluation is considered as a useful method for screening active ingredients in complex mixtures. This study was designed to develop an orthogonal partial least squares model for screening bioactive quality control markers of QishenYiqi dripping pills based on the fingerprint-efficacy relationship. First, the chemical fingerprints of 49 batches of QishenYiqi dripping pill samples were established by ultra-high performance liquid chromatography coupled with a photodiode array detector. Second, ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry was exploited to systematically investigate the 36 copossessing fingerprint components in QishenYiqi dripping pills. The vascular protective activity of QishenYiqi dripping pills was determined by using a cell counting kit-8 assay. Finally, fingerprint-efficacy relationship was established by orthogonal partial least squares model. The results indicated that ten components exhibited strong correlation with vascular protective activity, and these were preliminarily screened as quality control markers. The present study provided a novel idea for the study of the pharmacodynamic material basis and quality evaluation of QishenYiqi dripping pills. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. 曾侯乙钟磬与中原钟磬之比较%Comparison of the Zeng State Marquis Yi Bells and Stone Chines with Their Counterparts in the Central Plains

    Institute of Scientific and Technical Information of China (English)

    赵世纲

    2002-01-01

    Among the 125 pieces of musical instruments from Zenghouyi Tomb, bronzechimes and chime stones occupy four fifth, while more than one thousand pieces of bronzechimes and chime stones have been found in the Central Plains. This paper, based onthe analysis of composition, designs and temperament of bronze chimes and chime stones,proposes that the bronze chimes and chime stones from Zenghouyi Tomb originated fromthe Central Plains and thus belonged to the musical tradition of the Central Plains.

  13. Türkiye'de Halk Kütüphaneleri Bölge Seminerleri: "İyi Uygulama Örneği" Olarak Bir Deneyimin Değerlendirilmesi

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    Bülent Yılmaz

    2008-03-01

    Full Text Available Bu çalışmada, Türkiye 'deki halk kütüphanelerinde çalışan kütüphaneci ve yöneticiler için 2006-2007 yıllarında Türk Kütüphaneciler Derneği, Goethe- Insitut ve Kültür ve Turizm Bakanlığı Kütüphaneler ve Yayımlar Genel Müdürlüğü tarafından düzenlenen bölge seminerleri değerlendirilmiştir. Bu bağlamda, önce, seminerler süreci özetlenmiş, seminerlerin hedef, kapsam, yöntem ve organizasyon yapıları ele alınmıştır. Daha sonra, seminer katılımcılarına uygulanan anket ile elde edilen veriler irdelenmiştir. Sonuçta, çalışan halk kütüphanecisi ve yöneticilerinin yaklaşık %25 'ine ulaşıldığı 9 bölge seminerinin Türk halk kütüphanecileri için son derece katkı sağlayıcı olduğu ve hizmet içi eğitim konusunda ciddi gereksinimleri bulunduğu anlaşılmıştır.

  14. Öznel İyi Oluşun Yapısı ve Anababa Tutumları, Özsaygı Ve Sosyal Destekle İlişkisi: Bir Model Sınaması

    OpenAIRE

    Türkmen, Mustafa

    2012-01-01

    In this study, it is aimed to test the structure formed by some variables that might influence the formation of subjective well-being as a whole (or as a model). When searching answers to research questions consulted to structural equation modeling techniques. The research group is determined as 369 students training at the Faculty of Educational Sciences of Ankara University. Results of analysis of data showed that the structure which relays in the first model is supported as a whole. It is ...

  15. YEREL TARİH SOSYAL BİLGİLER/TARİH ÖĞRETİM PROGRAMLARINDA YER ALMALI MIDIR?: "MALATYALI OLMAK" İLE "MALATYA’YI BİLMEK" AYNI ŞEY MİDİR?

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    Yücel KABAPINAR

    2016-10-01

    Full Text Available Sosyal Bilgiler/Tarih dersleri kapsamında yerel tarih çalışmaları, yeni bir kavram olarak 2005 yılı sonrası öğretim programıyla gündeme gelmiştir. Ancak yerel tarih çalışmalarının okul boyutunda işlevsel olduğunu söylemek çok da olanaklı değildir. Peki, yerel tarih gerçekten gerekli midir, ihtiyaç mıdır? Bu araştırmada “yerel tarih, Sosyal Bilgiler ve Tarih öğretim programlarında yer almalı mıdır” sorusuna öğrenci ve öğretmen görüşleri çerçevesinde cevap aranmıştır. Nitel araştırma tasarımı kullanılan bu çalışmada, katılımcıların seçiminde amaçlı örneklem seçiminden yararlanılmıştır. Verilerin toplanmasında yarı yapılandırılmış görüşme ile anket formu kullanılmıştır. Bu kapsamda Malatya ilinde görev yapan 5 Sosyal Bilgiler ve 5 Tarih öğretmeniyle görüşme yapılmıştır. Malatya’da öğrenim görmekte olan 10 ortaokul ve 10 lise son sınıf öğrencisine de anket uygulanmıştır. Elde edilen verilerin çözümlenmesinde içerik analizi yöntemi kullanılmıştır.  Öğrencilerin yaşadıkları şehrin tarihi, kültürel özelliklerine ilişkin yeterli düzeyde bilgi sahibi olmadıkları ulaşılan genel sonuçlardan biridir. Çalışmaya katılan öğretmenler de yerel tarihin öğretim programlarında yer alması gerektiğinin altını çizmişlerdir.Anahtar Kelimeler: Yerel tarih, Sosyal Bilgiler Öğretimi, Tarih ÖğretimiSHOULD LOCAL HISTORY HAVE A PLACE in SOCIAL STUDIES/HISTORY PROGRAMME? IS IT SAME “TO BE FROM MALATYA” and “TO KNOW ABOUT MALATYA”?Abstract: Local history studies within the framework of Social Studies/History courses have emerged as a new concept after the new teaching programme launched in 2005. To date it appears that local history has not been widely used in school settings. The question whether the local history studies are of importance and necessity in learning and teaching Social Studies/History needs to be illuminated. The basic motive of the present study is to answer whether local history has a place in the social studies and history curricula. This question motivated the present study. The study was designed in the line of constructivist orientation where qualitative research design was adopted. Social Studies and History teachers and their students participated in the study. Participants were selected on the basis of purposeful sampling. A questionnaire was designed and distributed to secondary (n= 10 and high school students (n= 10. Semi-structured interview form was another research instrument. Social Studies (n= 5 and History teachers (n= 5 working at schools located in Malatya were interviewed. Content analysis were benefitted in analyzing the written and verbal data obtained through questionnaire and interview protocols. The results of analysis revealed that students do have limited and superficial knowledge about the city in which they live. According to the findings majority of the Social Studies and History teachers verbalized that the local history is an important concept and should have a room in the curriculum.  Keywords: Local History, Teaching Social Studies, Teaching History

  16. Knockdown of a HIF-2α promoter upstream long noncoding RNA impairs colorectal cancer stem cell properties in vitro through HIF-2α downregulation

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    Yao J

    2015-11-01

    Full Text Available Jie Yao,1,* Jianxiong Li,2,* Peiliang Geng,2,* Yi Li,3,* Hong Chen,3 Yunfeng Zhu2 1Department of Oncology, People’s Liberation Army No 161 Hospital, Wuhan, 2Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital, Beijing, 3Department of Oncology, Kunming General Hospital of Chendu Military Command, Kunming, People’s Republic of China *These authors contributed equally to this work Abstract: Currently, various long noncoding RNAs (lncRNAs have been identified as key regulators of multiple cancers. However, cancer stem cell (CSC-related lncRNAs have rarely been reported. In this study, we found an lncRNA that is a promoter upstream transcript of hypoxia-inducible factor-2α (HIF-2α, and we named it “lncRNA-HIF2PUT”. The function of HIF-2α is closely connected with “stem cell-like” properties, and the function of PROMPTs is often associated with the adjacent protein-coding transcripts. Herein, we showed that the expression of lncRNA-HIF2PUT was significantly correlated with HIF-2α in colorectal cancer (CRC tissues. Knockdown of lncRNA-HIF2PUT blocked the HIF-2α expression and inhibited the CSC properties in CRC cell lines DLD-1 and HT29. LncRNA-HIF2PUTsmall interfering RNA transfection resulted in decreased stemness genes expression, impaired colony formation, and spheroid formation ability, retarded migration, and invasion of the cells. These data suggest that lncRNA-HIF2PUT may be a regulator of HIF-2α and a mediator of CSCs in CRC. Keywords: HIF-2α, long noncoding RNA, colorectal cancer, stem cell properties

  17. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

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    Ding YP

    2017-03-01

    Full Text Available Yipeng Ding,* Heping Xu,* Jinjian Yao, Dongchuan Xu, Ping He, Shengyang Yi, Quanni Li, Yuanshui Liu, Cibing Wu, Zhongjie Tian Department of Emergency, People’s Hospital of Hainan Province, Haikou, Hainan, People’s Republic of China *These authors contributed equally to this work Objective: We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1, which has been associated with telom­ere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD in a Chinese Han population.Methods: In a case–control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs and 95% confidence intervals (CIs were calculated using unconditional logistic regression after adjusting for age and gender.Results: In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10–0.82; P=0.02. In the genetic model analysis, we found that the “C/C” genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13–0.86; P=0.022 and recessive model (OR =0.32; 95% CI =0.12–0.80; P=0.009.Conclusion: Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population. Keywords: RTEL1, chronic obstructive pulmonary disease, COPD, gene polymorphisms, association study, case-control study

  18. Bypassing multidrug resistance in human breast cancer cells with lipid/polymer particle assemblies

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    Li B

    2012-01-01

    Full Text Available Bo Li1, Hui Xu2, Zhen Li1, Mingfei Yao1, Meng Xie1, Haijun Shen1, Song Shen1, Xinshi Wang1, Yi Jin11College of Pharmaceutical sciences, Zhejiang University, Hangzhou, 2No. 202 Hospital of People's Liberation Army, Shenyang, ChinaBackground: Multidrug resistance (MDR mediated by the overexpression of adenosine triphosphate (ATP-binding cassette (ABC transporters, such as P-glycoprotein (P-gp, remains one of the major obstacles to effective cancer chemotherapy. In this study, lipid/particle assemblies named LipoParticles (LNPs, consisting of a dimethyldidodecylammonium bromide (DMAB-modified poly(lactic-co-glycolic acid (PLGA nanoparticle core surrounded by a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC shell, were specially designed for anticancer drugs to bypass MDR in human breast cancer cells that overexpress P-gp.Methods: Doxorubicin (DOX, a chemotherapy drug that is a P-gp substrate, was conjugated to PLGA and encapsulated in the self-assembled LNP structure. Physiochemical properties of the DOX-loaded LNPs were characterized in vitro. Cellular uptake, intracellular accumulation, and cytotoxicity were compared in parental Michigan Cancer Foundation (MCF-7 cells and P-gp-overexpressing, resistant MCF-7/adriamycin (MCF-7/ADR cells.Results: This study found that the DOX formulated in LNPs showed a significantly increased accumulation in the nuclei of drug-resistant cells relative to the free drug, indicating that LNPs could alter intracellular traffic and bypass drug efflux. The cytotoxicity of DOX loaded-LNPs had a 30-fold lower half maximal inhibitory concentration (IC50 value than free DOX in MCF-7/ADR, measured by the colorimetric cell viability (MTT assay, correlated with the strong nuclear retention of the drug.Conclusion: The results show that this core-shell lipid/particle structure could be a promising strategy to bypass MDR.Keywords: chemotherapy, drug delivery, polymeric nanoparticles, multidrug resistance

  19. Proceedings of the 2016 China Cancer Immunotherapy Workshop

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    Bin Xue

    2016-10-01

    Full Text Available Table of contents A1 Proceedings of 2016 China Cancer Immunotherapy Workshop, Beijing, China Bin Xue, Jiaqi Xu, Wenru Song, Zhimin Yang, Ke Liu, Zihai Li A2 Set the stage: fundamental immunology in forty minutes Zihai Li A3 What have we learnt from the anti-PD-1/PD-L1 therapy of advanced human cancer? Lieping Chen A4 Immune checkpoint inhibitors in lung cancer Edward B. Garon A5 Mechanisms of response and resistance to checkpoint inhibitors in melanoma Siwen Hu-Lieskovan A6 Checkpoint inhibitor immunotherapy in lymphoid malignancies Wei Ding A7 Translational research to improve the efficacy of immunotherapy in genitourinary malignancies Chong-Xian Pan A8 Immune checkpoint inhibitors in gastrointestinal malignancies Weijing Sun A9 What’s next beyond PD-1/PDL1? Yong-Jun Liu A10 Cancer vaccines: new insights into the oldest immunotherapy strategy Lei Zheng A11 Bispecific antibodies for cancer immunotherapy Delong Liu A12 Updates on CAR-T immunotherapy Michel Sadelain A13 Adoptive T cell therapy: personalizing cancer treatment Cassian Yee A14 Immune targets and neoantigens for cancer immunotherapy Rongfu Wang A15 Phase I/IIa trial of chimeric antigen receptor modified T cells against CD133 in patients with advanced and metastatic solid tumors Meixia Chen, Yao Wang, Zhiqiang Wu, Hanren Dai, Can Luo, Yang Liu, Chuan Tong, Yelei Guo, Qingming Yang, Weidong Han A16 Cancer immunotherapy biomarkers: progress and issues Lisa H. Butterfield A17 Shaping of immunotherapy response by cancer genomes Timothy A. Chan A18 Unique development consideration for cancer immunotherapy Wenru Song A19 Immunotherapy combination Ruirong Yuan A20 Immunotherapy combination with radiotherapy Bo Lu A21 Cancer immunotherapy: past, present and future Ke Liu A22 Breakthrough therapy designation drug development and approval Max Ning A23 Current European regulation of innovative oncology medicines: opportunities for immunotherapy Harald Enzmann, Heinz Zwierzina

  20. Magnetic responsive hydroxyapatite composite scaffolds construction for bone defect reparation

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    Zeng XB

    2012-07-01

    Full Text Available Xiao Bo Zeng, Hao Hu, Li Qin Xie, Fang Lan, Wen Jiang, Yao Wu, Zhong Wei GuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaIntroduction: In recent years, interest in magnetic biomimetic scaffolds for tissue engineering has increased considerably. A type of magnetic scaffold composed of magnetic nanoparticles (MNPs and hydroxyapatite (HA for bone repair has been developed by our research group.Aim and methods: In this study, to investigate the influence of the MNP content (in the scaffolds on the cell behaviors and the interactions between the magnetic scaffold and the exterior magnetic field, a series of MNP-HA magnetic scaffolds with different MNP contents (from 0.2% to 2% were fabricated by immersing HA scaffold into MNP colloid. ROS 17/2.8 and MC3T3-E1 cells were cultured on the scaffolds in vitro, with and without an exterior magnetic field, respectively. The cell adhesion, proliferation and differentiation were evaluated via scanning electron microscopy; confocal laser scanning microscopy; and 3-(4,5-Dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT, alkaline phosphatase, and bone gla protein activity tests.Results: The results demonstrated the positive influence of the magnetic scaffolds on cell adhesion, proliferation, and differentiation. Further, a higher amount of MNPs on the magnetic scaffolds led to more significant stimulation.Conclusion: The magnetic scaffold can respond to the exterior magnetic field and engender some synergistic effect to intensify the stimulating effect of a magnetic field to the proliferation and differentiation of cells.Keywords: magnetic therapy, magnetic nanoparticles, bone repair, magnetic responsive

  1. Prescription patterns of Chinese herbal products for patients with sleep disorder and major depressive disorder in Taiwan.

    Science.gov (United States)

    Chen, Yi-Lin; Lee, Chien-Ying; Huang, Kuang-Hua; Kuan, Yu-Hsiang; Chen, Ming

    2015-08-02

    Chinese herbal products (CHPs) are commonly prescribed for sleep disorder and major depressive disorder (MDD). The aim of this study was to investigate the prescription patterns of CHPs and Western medicine for patients with these disorders in Taiwan, and analyze the frequency of using single herbs (SHs) and herbal formulas (HFs). In this retrospective population-based study secondary data analysis was performed using data from Taiwan's Longitudinal Health Insurance Database (LHID) between January 2007 and December 2011. In total, 1000,000 beneficiaries from the LHID were randomly selected from the 2010 registry for beneficiaries of the National Health Insurance Research Database. Patients with sleep disorder and MDD according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes 307.40 and 311, respectively. Among a total of 11,030 patients with sleep disorder, 9619 used Western medicine, 1334 used CHPs, and 77 used both, Among a total of 11,571 patients with MDD, 11,389 used Western medicine, 131 used CHPs, and 51 used both. Regardless of disorder type, women were predominant The majority of the patients were aged 22-44 years, had a monthly income of NT$17,281-NT$22,800, and lived in an area with Level 1 and Level 2 urbanization. Of the patients with sleep disorder, 1411 had used CHPs and visited a clinic 5298 times on average. Of the patients with MDD, 182 had used CHPs and visited a clinic 755 times on average. The three most commonly used SHs and HFs were Ziziphi Spinosae Semen, Polygoni Multiflori Caulis, and Polygalae Radix, and Jia-Wei-Xiao-Yao-San, Suan-Zao-Ren-Tang, and Chai-Hu-Chia-Lung-Ku-Mu-Li-Tang, respectively. Chinese herbal products including SHs and HFs are prescribed for patients with sleep disorder and MDD. However, the efficacy and safety of CHPs for sleep disorder and MDD need to be further evaluated. Copyright © 2015. Published by Elsevier Ireland Ltd.

  2. Rehabilitation for a child with recalcitrant anti-N-methyl-D-aspartate receptor encephalitis: case report and literature review

    Directory of Open Access Journals (Sweden)

    Guo YH

    2014-11-01

    Full Text Available Yao-Hong Guo,1 Ta-Shen Kuan,1,2 Pei-Chun Hsieh,1 Wei-Chih Lien,1 Chun-Kai Chang,1 Yu-Ching Lin1–3 1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Physical Medicine and Rehabilitation, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan Abstract: Anti-N-methyl-d-aspartate (anti-NMDA receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6–8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs. Keywords: anti-NMDA receptor encephalitis, autoimmune encephalitis, rehabilitation, cognition deficits

  3. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    Science.gov (United States)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    Tegel, Inga Schellenberg, Falko M Schappacher, Rainer Pöttgen, Joachim Deisenhofer, Axel Günther, Florian Schrettle, Alois Loidl and Dirk Johrendt The superconductor KxSr1-xFe2As2: normal state and superconducting properties B Lv, M Gooch, B Lorenz, F Chen, A M Guloy and C W Chu Effect of 3d transition metal doping on the superconductivity in quaternary fluoroarsenide CaFeAsF Satoru Matsuishi, Yasunori Inoue, Takatoshi Nomura, Youichi Kamihara, Masahiro Hirano and Hideo Hosono Influence of the rare-earth element on the effects of the structural and magnetic phase transitions in CeFeAsO, PrFeAsO and NdFeAsO Michael A McGuire, Raphaël P Hermann, Athena S Sefat, Brian C Sales, Rongying Jin, David Mandrus, Fernande Grandjean and Gary J Long Heat capacity measurements on FeAs-based compounds: a thermodynamic probe of electronic and magnetic states P J Baker, S R Giblin, F L Pratt, R H Liu, G Wu, X H Chen, M J Pitcher, D R Parker, S J Clarke and S J Blundell Spin fluctuations, interband coupling and unconventional pairing in iron-based superconductors Zi-Jian Yao, Jian-Xin Li and Z D Wang Superconductivity induced by Ni doping in BaFe2As2 single crystals L J Li, Y K Luo, Q B Wang, H Chen, Z Ren, Q Tao, Y K Li, X Lin, M He, Z W Zhu, G H Cao and Z A Xu Metamagnetic transition in EuFe2As2 single crystals Shuai Jiang, Yongkang Luo, Zhi Ren, Zengwei Zhu, Cao Wang, Xiangfan Xu, Qian Tao, Guanghan Cao and Zhu'an Xu Pressure dependence of the thermoelectric power of the iron-based high-Tc superconductor SmFeAsO0.85 N Kang, P Auban-Senzier, C R Pasquier, Z A Ren, J Yang, G C Che and Z X Zhao Superconductivity in some heavy rare-earth iron arsenide REFeAsO1-δ (RE = Ho, Y, Dy and Tb) compounds Jie Yang, Xiao-Li Shen, Wei Lu, Wei Yi, Zheng-Cai Li, Zhi-An Ren, Guang-Can Che, Xiao-Li Dong, Li-Ling Sun, Fang Zhou and Zhong-Xian Zhao The delicate electronic and magnetic structure of the LaFePnO system (Pn = pnicogen) S Lebègue, Z P Yin and W E Pickett

  4. Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis

    Directory of Open Access Journals (Sweden)

    Yang HW

    2012-10-01

    Full Text Available Hung-Wei Yang,1,* Mu-Yi Hua,1,* Kun-Ju Lin,2,* Shiaw-Pyng Wey,3 Rung-Ywan Tsai,4 Siao-Yun Wu,5 Yi-Ching Lu,5 Hao-Li Liu,6 Tony Wu,7 Yunn-Hwa Ma5 1Chang Gung Molecular Medicine Research Center, Department of Chemical and Materials Engineering, 2Molecular Imaging Center, Department of Nuclear Medicine, Chang Gung Memorial Hospital, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China; 3Department of Medical Imaging and Radiological Sciences, 4Electronics and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsin-chu, Taiwan, Republic of China; 5Department of Physiology and Pharmacology and Healthy Aging Research Center, 6Department of Electrical Engineering, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China; 7Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, Tao-Yuan, Taiwan, Republic of China*These authors contributed equally to this workAbstract: Low-toxicity magnetic nanocarriers (MNCs composed of a shell of poly [aniline-co-N-(1-one-butyric acid aniline] over a Fe3O4 magnetic nanoparticle core were developed to carry recombinant tissue plasminogen activator (rtPA in MNC-rtPA for targeted thrombolysis. With an average diameter of 14.8 nm, the MNCs exerted superparamagnetic properties. Up to 276 µg of active rtPA was immobilized per mg of MNCs, and the stability of the immobilized rtPA was greatly improved during storage at 4°C and 25°C. In vitro thrombolysis testing with a tubing system demonstrated that magnet-guided MNC-rtPA showed significantly improved thrombolysis compared with free rtPA and reduced the clot lysis time from 39.2 ± 3.2 minutes to 10.8 ± 4.2 minutes. In addition, magnet-guided MNC-rtPA at 20% of the regular rtPA dose restored blood flow within 15–25 minutes of treatment in a rat embolism model without triggering hematological toxicity. In conclusion, this improved system is based on magnetic targeting accelerated thrombolysis and is

  5. Evaluation of the risk factors of depressive disorders comorbid with obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Cai LQ

    2017-01-01

    Full Text Available Liqiang Cai,1 Luoyi Xu,1 Lili Wei,1 Yi Sun,2 Wei Chen1,3 1Department of Psychiatry, Sir Run Run Shaw Hospital, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, 2Department of Electroencephalogram, Sir Run Run Shaw Hospital, 3Key Laboratory of Medical Neurobiology, Chinese Ministry of Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China Objective: Overlap of obstructive sleep apnea (OSA complicates diagnosis of depressive disorder and renders antidepressant treatment challenging. Previous studies have reported that the incidence of OSA is higher in patients with depression than in the general population. The purpose of this article was to investigate clinical risk factors to predict OSA in depression disorders.Methods: A total of 115 patients diagnosed with major depressive disorder (MDD and bipolar disorder (in a major depressive episode, who underwent overnight polysomnography, were studied retrospectively. They were divided into two groups: non-OSA and OSA. The patients who had apnea–hypopnea index (AHI <5 were defined as the non-OSA group, whereas the OSA group was defined as those with an AHI ≥5. Logistic regression was used to analyze the association among AHI and clinical factors, including sex, age, body mass index (BMI, Hamilton Depression Rating Scale (HAMD, Hamilton Anxiety Rating Scale, Pittsburgh Sleep Quality Index (PSQI, and diagnosis (MDD or bipolar disorder [in a major depressive episode].Results: In 115 patients, 51.3% had OSA. Logistic regression analysis showed significant associations between AHI and diagnosis (MDD or bipolar disorder [in a major depressive episode], BMI, HAMD, and PSQI (P<0.05.Conclusion: The findings of our study suggested that the rate of depression being comorbid with OSA is remarkably high and revealed that there is a high rate of undetected OSA among depressive disorder patients and untreated OSA among mood

  6. A Computing Platform for Parallel Sparse Matrix Computations

    Science.gov (United States)

    2016-01-05

    REPORT NUMBER 19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER Ahmed Sameh Ahmed H. Sameh, Alicia Klinvex, Yao Zhu 611103 c. THIS PAGE The...PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: Discipline Yao Zhu 0.50 Alicia Klinvex 0.10 0.60 2 Names of Post Doctorates Names of Faculty Supported...PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: NAME Total Number: NAME Total Number: Yao Zhu Alicia Klinvex 2 ...... ...... Sub Contractors (DD882) Names of other

  7. 33 ヤオ族儀礼神画の研究 -広西チワン族自治区恭城ヤオ族自治県蓮華鎮黄泥岡村盤王祭を事例として-

    OpenAIRE

    譚, 静; Tan, Jing

    2014-01-01

    Yao is one of the 55 ethnic groups in China. It is widely distributed in the south part of China, for example, the Hunan province, Yunnan province, the Guangxi Zhuang Autonomous Region, Guangdong province and the Southeast Asia (Thailand, Laos, Vietnam etc.)This article is emphasized on the Yao in Huangnigang Village, Lianhua Town, Gongcheng Yao Autonomous County, which is located in the northwest part of theGuangxi Zhuang Autonomous Region neighboring the Hunan province. So far the Yao peopl...

  8. A comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients

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    Chen LF

    2013-08-01

    Full Text Available Li-Fen Chen,1 Ching-En Lin,1–3 Yu-Ching Chou,4 Wei-Chung Mao,1,5 Yi-Chyan Chen,1–3 Nian-Sheng Tzeng1,6 1Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 2Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, Taipei, Taiwan; 3School of Medicine, Tzu Chi University, Hualien, Taiwan; 4School of Public Health, National Defense Medical Center, Taipei City, Taiwan; 5Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei City, Taiwan; 6Student Counseling Center, National Defense Medical Center, Taipei City, Taiwan Objective: Complex sleep behaviors (CSBs are classified as “parasomnias” in the International Classification of Sleep Disorders, Second Edition (ICSD-2. To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan. Methods: Subjects (N = 1,220 using zolpidem or zopiclone were enrolled from the psychiatric outpatient clinics of a medical center in Taiwan over a 16-month period in 2006–2007. Subjects with zolpidem (N = 1,132 and subjects with zopiclone (N = 88 were analyzed. All subjects completed a questionnaire that included demographic data and complex sleep behaviors after taking hypnotics. Results: Among zolpidem and zopiclone users, 3.28% of patients reported incidents of somnambulism or amnesic sleep-related behavior problems. The incidence of CSBs with zolpidem and zopiclone were 3.27%, and 3.41%, respectively, which was significantly lower than other studies in Taiwan. Conclusion: These results serve as a reminder for clinicians to make inquiries regarding any unusual performance of parasomnic activities when prescribing zolpidem or zopiclone. Keywords: parasomnia, somnambulism, amnesic sleep-related behavior, sleepwalking, zolpidem, zopiclone

  9. Prognostic value of Notch-1 expression in hepatocellular carcinoma: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Wu T

    2015-10-01

    Full Text Available Tao Wu,1 Min Jiao,1 Li Jing,1 Min-Cong Wang,1 Hai-Feng Sun,2 Qing Li,1 Yi-Yang Bai,1 Yong-Chang Wei,1 Ke-Jun Nan,1 Hui Guo1 1Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Oncology, Shaanxi Cancer Hospital, Xi’an, People’s Republic of China Abstract: Association of Notch-1 expression with prognosis of patients with hepatocellular carcinoma (HCC remains controversial. We conducted a meta-analysis to reevaluate the association of Notch-1 expression with clinicopathological characteristics and prognosis of HCC. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure were searched to look for relevant studies. The association between Notch-1 expression and clinicopathological parameters and overall survival (OS was then reassessed using the meta-analysis for odds ratio (OR or hazard ratio (HR and 95% confidence interval (CI. A total of seven studies, including 810 HCC patients, were eligible for the meta-analysis. Our data showed that high Notch-1 expression was able to predict poor OS (HR 1.50, 95% CI 1.17–1.83, P=0.0001. The pooled OR showed that high Notch-1 expression was significantly associated with tumor metastasis (OR 0.37, 95% CI 0.16–0.86, P=0.02 and tumor size >5 cm (OR 0.48, 95% CI 0.26–0.88, P=0.02. In contrast, there was no association between high Notch-1 expression and tumor differentiation, late TNM stage, tumor number, and portal vein invasion of HCC. In conclusion, Notch-1 overexpression might predict poorer survival and more aggressive behavior in patients with HCC. Keywords: hepatocellular carcinoma, Notch-1, prognosis, clinicopathological features, meta-analysis

  10. Effectiveness of stress management in patients undergoing transrectal ultrasound-guided biopsy of the prostate

    Directory of Open Access Journals (Sweden)

    Chiu LP

    2016-02-01

    Full Text Available Li-Pin Chiu,1,2 Heng-Hsin Tung,3 Kuan-Chia Lin,3 Yu-Wei Lai,1,4 Yi-Chun Chiu,1,4 Saint Shiou-Sheng Chen,1,4 Allen W Chiu1,4 1Division of Urology, Taipei City Hospital, 2University of Taipei, General Education Center, 3School of Nursing, Department of Care Management, National Taipei University of Nursing and Health Science, 4Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China Background: To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS-guided biopsy of the prostate.  Methods: Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Stress management included music therapy and one-on-one simulation education. Before and after the TRUS biopsy, the patients’ state-anxiety inventory score, pain visual analogue scale (VAS, respiratory rate, heart rate, and blood pressure were obtained.  Results: There were no differences in baseline and disease characteristics between the two groups. The VAS in both groups increased after the TRUS biopsy, but the difference in pre- and postbiopsy VAS scores was significantly lower in the experimental group (P=0.03. Patients in both groups experienced mild anxiety before and after the biopsy, but those in the experimental group displayed a significantly greater decrease in postbiopsy state-anxiety inventory score compared to the control group (P=0.02.Conclusion: Stress management can alleviate anxiety and pain in patients who received a TRUS biopsy of the prostate under local anesthesia. Keywords: anxiety, pain, stress management, transrectal ultrasound-guided biopsy of the prostate

  11. Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway

    Directory of Open Access Journals (Sweden)

    Gong C

    2017-12-01

    Full Text Available Cheng Gong,1 Zongyuan Yang,1 Lingyun Zhang,2 Yuehua Wang,2 Wei Gong,2 Yi Liu3 1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Department of Oncology, XiangYang Central Hospital, Hubei University of Arts and Science, XiangYang, 3Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China Abstract: Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin’s radiosensitization and regulation of endoplasmic reticulum (ER stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expression of p53 protein; phosphorylation on serine 15 and 20 increased in combination with X-irradiation. Quercetin pretreatment could potentiate radiation-induced cell death. The combination of irradiation and quercetin treatment aggravated DNA damages and caused typical apoptotic cell death; as well the expression of Bax and p21 elevated and the expression of Bcl-2 decreased. Knocking down of p53 could reverse all the above effects under quercetin in combination with radiation. In addition, quercetin-induced radiosensitization was through stimulation of ATM phosphorylation. In human ovarian cancer xenograft model, combined treatment of quercetin and radiation significantly restrained the growth of tumors, accompanied with the activation of p53, CCAAT/enhancer-binding protein homologous protein, and γ-H2AX. Overall, these results indicated that quercetin acted as a promising radiosensitizer through p53-dependent ER stress signals. Keywords: quercetin, p53, endoplasmic reticulum stress, DNA double-strand breaks, eIF-2α (eukaryotic initiation factor 2α, ATM kinase

  12. Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study

    Directory of Open Access Journals (Sweden)

    Chan EC

    2012-02-01

    Full Text Available Dave Wei-Chih Chen1,2, Jun-Yi Liao3, Shih-Jung Liu2, Err-Cheng Chan41Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 2Department of Mechanical Engineering, 3Graduate Institute of Medical Mechatronics, 4School of Medical Technology, Chang Gung University, Kwei-San, Tao-Yuan, TaiwanBackground: The purpose of this study was to develop novel sandwich-structured nanofibrous membranes to provide sustained-release delivery of vancomycin, gentamicin, and lidocaine for repair of infected wounds.Methods: To prepare the biodegradable membranes, poly(D, L-lactide-co-glycolide (PLGA, collagen, and various pharmaceuticals, including vancomycin, gentamicin, and lidocaine, were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into sandwich-structured membranes with PLGA/collagen as the surface layers and PLGA/drugs as the core. An elution method and a high-pressure liquid chromatography assay were used to characterize in vivo and in vitro drug release from the membranes. In addition, repair of infected wounds in rats was studied. Histological examination of epithelialization and granulation at the wound site was also performed.Results: The biodegradable nanofibrous membranes released large amounts of vancomycin and gentamicin (well above the minimum inhibition concentration and lidocaine in vivo for more than 3 weeks. A bacterial inhibition test was carried out to determine the relative activity of the antibiotics released. The bioactivity ranged from 40% to 100%. The nanofibrous membranes were functionally active in treating infected wounds, and were very effective as accelerators in early-stage wound healing.Conclusion: Using the electrospinning technique, we will be able to manufacture biodegradable, biomimetic, nanofibrous, extracellular membranes for long-term delivery of various drugs.Keywords: nanofibrous, sandwich-structured, drug-eluting membranes, electrospinning, release characteristics, repair, wound

  13. Motivation for everyday social participation in cognitively able individuals with autism spectrum disorder

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    Chen YW

    2015-10-01

    Full Text Available Yu-Wei Chen,1 Anita C Bundy,1 Reinie Cordier,2 Yi-Ling Chien,3 Stewart L Einfeld1,4 1Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia; 2School of Occupational Therapy and Social Work, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; 3Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; 4Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia Objective: The purpose of the present study was to examine motivation for the contextual nature of motivations for social participation in cognitively able adolescents and adults with autism spectrum disorder, using self-determination theory as a theoretical framework.Methods: Fourteen Australians and 16 Taiwanese (aged 16–45 years with Asperger’s syndrome and high functioning autism were asked to carry a device which prompted them seven times/day for 7 days, to record what they were doing, with whom, perceived difficulty and social reciprocity, and the reasons for engaging in a situation, which were then coded into degree of self-determination.Results: Multilevel analyses showed that participants were more likely to be self-determined while engaging in “solitary/parallel leisure” and “social activities” than in other types of activities. Interactions with “family members” and “casual/intimate friends” were also positively associated with self-determined motivation. Further, participants were more likely to perceive higher levels of being listened to during interaction with casual/intimate friends than in interaction with other people. Global social anxiety served as a moderator for their perceptions of difficulty and social reciprocity during social engagement.Conclusion: The findings highlight the context-dependent motivations for social engagement of cognitively able individuals with autism spectrum disorder. Keywords: autism, real-life experience, social

  14. Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles

    Directory of Open Access Journals (Sweden)

    Jie Lai

    2009-12-01

    Full Text Available Jie Lai1,2, Yi Lu1, Zongning Yin2, Fuqiang Hu3, Wei Wu11School of Pharmacy, Fudan University, Shanghai, China, 2West China School of Pharmacy, Sichuan University, Chengdu, China, 3School of Pharmacy, Zhejiang University, Hangzhou, ChinaAbstract: Efforts to improve the oral bioavailability of cyclosporine A (CyA remains a challenge in the field of drug delivery. In this study, glyceryl monooleate (GMO/poloxamer 407 cubic nanoparticles were evaluated as potential vehicles to improve the oral bioavailability of CyA. Cubic nanoparticles were prepared via the fragmentation of a bulk GMO/poloxamer 407 cubic phase gel by sonication and homogenization. The cubic inner structure formed was verified using Cryo-TEM. The mean diameters of the nanoparticles were about 180 nm, and the entrapment efficiency of these particles for CyA was over 85%. The in vitro release of CyA from these nanoparticles was less than 5% at 12 h. The results of a pharmacokinetic study in beagle dogs showed improved absorption of CyA from cubic nanoparticles as compared to microemulsion-based Neoral®; higher Cmax (1371.18 ± 37.34 vs 969.68 ± 176.3 ng mL-1, higher AUC0–t (7757.21 ± 1093.64 vs 4739.52 ± 806.30 ng h mL-1 and AUC0–∞ (9004.77 ± 1090.38 vs 5462.31 ± 930.76 ng h mL-1. The relative oral bioavailability of CyA cubic nanoparticles calculated on the basis of AUC0–∞ was about 178% as compared to Neoral®. The enhanced bioavailability of CyA is likely due to facilitated absorption by cubic nanoparticles rather than improved release.Keywords: nanoparticles, cubosomes, cyclosporine A, glyceryl monooleate, oral drug delivery, bioavailability, beagle dogs

  15. Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

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    Kuo Y

    2017-04-01

    Full Text Available Yung-Chih Kuo, Chien-Wei Tsao Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, Taiwan, Republic of China Abstract: A drug delivery system of quercetin (QU-encapsulated liposomes (LS grafted with RMP-7, a bradykinin analog, and lactoferrin (Lf was developed to permeate the blood–brain barrier (BBB and rescue degenerated neurons, acting as an Alzheimer’s disease (AD pharmacotherapy. This colloidal formulation of QU-encapsulated LS grafted with RMP-7 and Lf (RMP-7-Lf-QU-LS was used to traverse human brain microvascular endothelial cells (HBMECs regulated by human astrocytes (HAs and to treat SK-N-MC cells after an insult with cytotoxic β-amyloid (Aβ fibrils. We found that surface RMP-7 and Lf enhanced the ability of QU to cross the BBB without inducing strong toxicity and damaging the tight junction. In addition, RMP-7-Lf-QU-LS significantly reduced Aβ-induced neurotoxicity and improved the viability of SK-N-MC cells. Compared with free QU, RMP-7-Lf-QU-LS could also significantly inhibit the expression of phosphorylated c-Jun N terminal kinase, phosphorylated p38, and phosphorylated tau protein at serine 202 by SK-N-MC cells, indicating an important role of RMP-7, Lf, and LS in protecting neurons against apoptosis. RMP-7-Lf-QU-LS is a promising carrier targeting the BBB to prevent Aβ-insulted neurodegeneration and may have potential in managing AD in future clinical applications. Keywords: Alzheimer’s disease, blood–brain barrier, β-amyloid, drug targeting, neurodegeneration, pharmacotherapy

  16. A new pulmonary rehabilitation maintenance strategy through home-visiting and phone contact in COPD

    Directory of Open Access Journals (Sweden)

    Li Y

    2018-01-01

    Full Text Available Yi Li,1,2 Jing Feng,3,4 Yuechuan Li,2 Wei Jia,2 Hongyu Qian2 1Graduate School, Tianjin Medical University, 2Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, 3Respiratory Department, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 4Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA Background: The benefit of pulmonary rehabilitation (PR for patients with COPD diminishes over time. We investigated a new strategy involving home-visit and phone contact and compared this to usual care in maintenance of PR benefits.Methods: A total of 172 stable COPD patients receiving 8-week PR program were recruited for this prospective study. Patients were allocated into usual care group (UC and PR maintenance group (PRMG randomly. Patients in PRMG participated in maintenance strategy at home under supervision through home-visit and phone contact. The 6-minute walking test (6MWT, COPD assessment test (CAT, and modified Medical Research Council scale (mMRC scores were evaluated every 3 months.Results: Of the total, 151 patients completed 8-week PR program with satisfactory PR results (p<0.001, and 104 patients finished the follow-up. The clinical improvements in 6MWT, CAT, and mMRC scores were maintained (p<0.001 in PRMG. In comparison, the benefit of PR diminished gradually in UC. The differences in 6MWT, CAT, and mMRC scores between groups were observed 6, 9, and 6 months after PR, respectively (p<0.05. Total frequency of exacerbations in PRMG was lower than UC (p=0.021.Conclusion: Maintenance strategy involving home-visit and phone contact is superior to usual care to preserve PR benefits, and reduces the acute COPD exacerbation rate. Keywords: COPD, pulmonary rehabilitation, 6-minute walking test, COPD assessment test, maintenance 

  17. MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells

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    Lee YY

    2018-04-01

    Full Text Available Yi-Yen Lee,1,2,* Aliaksandr A Yarmishyn,3,4,* Mong-Lien Wang,3,4 Hsiao-Yun Chen,4,5 Shih-Hwa Chiou,3–5 Yi-Ping Yang,4,5 Chun-Fu Lin,1,2 Pin-I Huang,2,6 Yi-Wei Chen,2,6 Hsin-I Ma,7 Ming-Teh Chen1,2 1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 2Faculty of Medicine, National Yang-Ming University, 3Institute of Pharmacology, National Yang-Ming University, 4Department of Medical Research, Taipei Veterans General Hospital, 5Institute of Clinical Medicine, National Yang Ming University, 6Cancer Center, Radiation Oncology Division, Taipei Veterans General Hospital, 7Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan *These authors contributed equally to this work Background: Glioblastoma multiforme (GBM is the most malignant brain tumor, and there is no effective treatment strategy. Patients with GBM have a median overall survival of only 14.6 months. Current treatment consists of safe and maximal surgical excision, followed by concurrent chemoradiotherapy and maintenance chemotherapy. There are several obstacles that hinder the effectiveness of this aggressive treatment. Temozolomide (TMZ is an oral alkylating drug that acts through alkylating the O6 position of guanine in DNA that leads to cell death. However, the expression and enzymatic activity of the DNA repair protein MGMT limits the therapeutic benefit from treatment with TMZ. MGMT reduces the efficacy of alkylating drugs by removing the methyl or alkyl group from damaged O6-methylguanine. Expression levels of MGMT play an important role in the outcome of GBM patients. miRNAs are a group of small regulatory RNAs that control target gene expression by binding to mRNAs. miR-142-3p has been found to be an important factor in the development and maintenance of the oncogenic state. Results: In this study, we sought to investigate whether miR-142-3p can regulate MGMT gene expression in GBM cells

  18. Reconciling late Quaternary transgressions in the Bohai Sea, China to the global sea level changes, and new linkage of sedimentary records to three astronomical rhythms

    Science.gov (United States)

    Yi, Liang

    2013-04-01

    Terminations. Science 326, 248-252. Ding, Z.L., Yu, Z.W., Rutter, N.W., Liu, T.S., 1994. Towards an orbital time scale for chinese loess deposits. Quaternary Science Reviews 13, 39-70. IOCAS (Institute of Oceanology, Chinese Academy of Sciences), 1985. Bohai Sea Geology. Science Press, Beijing, China. Liu, T., 2009. Loess and Arid Environment. Anhui Science & Techonology Press, Hefei, China. Wang, Y., Cheng, H., Edwards, R.L., An, Z., Wu, J., Chen, C.-C., Dorale, J.A., 2001. A High-Resolution Absolute-Dated Late Pleistocene Monsoon Record from Hulu Cave, China. Science 294, 2345-2348. Wang, Y., Cheng, H., Edwards, R.L., Kong, X., Shao, X., Chen, S., Wu, J., Jiang, X., Wang, X., An, Z., 2008. Millennial- and orbital-scale changes in the East Asian monsoon over the past 224,000 years. Nature 451, 1090-1093. Yi, L., Yu, H., Ortiz, J.D., Xu, X., Chen, S., Ge, J., Hao, Q., Yao, J., Shi, X., Peng, S., 2012a. Late Quaternary linkage of sedimentary records to three astronomical rhythms and the Asian monsoon, inferred from a coastal borehole in the south Bohai Sea, China. Palaeogeography, Palaeoclimatology, Palaeoecology 329-310, 101-117. Yi, L., Lai, Z.P., Yu, H.J., Xu, X.Y., Su, Q., Yao, J., Wang, X.L., Shi, X., 2012b. Chronologies of sedimentary changes in the south Bohai Sea, China: Constraints from luminescence and radiocarbon dating. Boreas, doi: 10.1111/j.1502-3885.2012.00271.x. Yi, L., Yu, H.J., Ortiz, J.D., Xu, X.Y., Qiang, X.K., Huang, H.J., Shi, X., Deng, C.L., 2012c. A reconstruction of late Pleistocene relative sea level in the south Bohai Sea, China, based on sediment grain-size analysis. Sedimentary Geology 281, 88-100. Zhao, S., Yang, G., Cang, S., Zhang, H., Huang, Q., Xia, D., Wang, Y., Liu, F., Liu, C., 1978. Transgression's stratas and shoreline changes in the south coast of Bohai Bay, China. Oceanologia et Limnologia Sinica 9, 15-25.

  19. PREFACE: The 15th International Conference on X-ray Absorption Fine Structure (XAFS15)

    Science.gov (United States)

    Wu, Z. Y.

    2013-04-01

    Committees and Staff Chair of the Conference Ziyu Wu International Advisory Committee Adam Hitchcock, Canada Adriano Filipponi, Italy Alain Manceau, France Alexander Soldatov, Russia Andrea Di Cicco, Italy Britt Hedman, USA Bruce Bunker, USA Calogero R. Natoli, Italy Christopher T. Chantler, Australia Frank M. F. De Groot, Netherlands Hiroyuki Oyanagi, Japan Ingolf Lindau, USA J. Mustre de Leon, México James E Penner-Hahn, USA Joaquin Garcia Ruiz, Spain John Evans, UK John J. Rehr, USA Kiyotaka Asakura, Japan Majed Chergui, Switzerland Mark Newton, UK Shiqiang Wei, P. R. China Tsun-Kong Sham, Canada Ziyu Wu, P. R. China International Program Committee Antonio Bianconi, Italy Augusto Marcelli, Italy Emad Flear Aziz, Germany Jinghua Guo, USA Joly Yves, France Masaharu Nomura, Japan Maurizio Benfatto, Italy Pieter Glatzel, France Shiqiang Wei, China Tiandou Hu, China Toshihiko Yokoyama, Japan Way-Faung Pong, Taiwan Xinyi Zhang, China Yi Xie, China Yuying Huang, China Zhonghua Wu, China Ziyu Wu, China Local Organizing Committee Bo He Fengchun Hu Haifeng Zhao Jing Zhang Meijuan Yu Qin Yu Shuo Zhang Wangsheng Chu Wei He Wei Xu Wensheng Yan Xiaomei Gong Xing Chen Yang Zou Yi Xia Zheng Jiang Zhi Xie Zhihu Sun Zhiyun Pan Additional Staff Chengxun Liu

  20. 75 FR 17396 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Science.gov (United States)

    2010-04-06

    ... diagnostics and therapeutics for scrub typhus and HIV infections'', Inventors: Wei Mei Ching, Chien Chung Chao... orientia tsutsugamushi to be used as a vaccine component against scrub typhus'', Inventors: Wei Mei Ching..., ``Recombinant antigens for diagnosis and prevention of murine typhus'', Inventor: Wei Mei Ching, issued June 9...

  1. Publisher Correction

    DEFF Research Database (Denmark)

    Turcot, Valérie; Lu, Yingchang; Highland, Heather M

    2018-01-01

    In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and E...

  2. Sex and the City

    NARCIS (Netherlands)

    Scheen, L.M.

    2006-01-01

    Mian Mian pouring beer on Wei Hui’s head in a Shanghai bar; Wei Hui baring her breasts at a press conference; threats on the Internet – self-labelled Beauty Writers Mian Mian and Wei Hui fear no accusations in their public catfight over alleged plagiarism in turn-of-the-century Shanghai. The rivalry

  3. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 2037 ... Vol 14, No 11 (2015), Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii, Abstract PDF. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, Wei-wei Wang, Yuan-yuan Luo, Hou-zhao Wang.

  4. Three new species of the genus Arge (Hymenoptera: Symphyta: Argidae from South Korea with key to species of the subfamily Arginae

    Directory of Open Access Journals (Sweden)

    Jin-Kyung Choi

    2016-06-01

    Full Text Available Three new species, Arge koreana Wei & Lee sp. nov. from South Korea, Arge pseudorejecta Wei & Lee sp. nov., and Arge shengi Wei & Lee sp. nov. from South Korea and China are described. Keys to known genera of Argidae and known species of Arginae from South Korea are provided.

  5. The 2nd International Conference on Agricultural and Biological Sciences (ABS 2016

    Directory of Open Access Journals (Sweden)

    Lei Pei

    2016-10-01

    Full Text Available Table of contents 01 The influence of soil salt content on the photosynthetic characteristics of spring wheat with trickle irrigation Lei Pei, Zhenhua Wang, Jinzhu Zhang, Wenhao Li 02 Comparing growth of fast-growing and slow-growing endophytes in plants via ergosterol quantification Adeline SY Ting, Yiing Y Chow, Sadequr Rahman 03 Transcriptome and digital gene expression analysis identifies putative triterpene saponin-biosynthetic genes of Panax notoginseng Rongchang Wei 04 Chitosan-assisted isolation and antioxidant evaluation of flavonoids from Sophora japonica L. Zhang Hu, Sidong Li, Chuyan Li, Zijuan Li 05 Two kinds of new characteristics of the ektexine ornamentation of ginkgo pollen Guoxia Wang, Yuzhen Yang, Gang Chen, Qing Luo 06 Analysis of nutrient and medicinal ingredients of Ginkgo pollen in different regions Guoxia Wang, Ruixia Liu, Yuzhen Yang, Lipei Chen 07 Photosynthetic performance of greening seedlings of seven species to drought stress Zhiyang Lie, Tongtong Zhou, Weilong Huang, Li Xue 08 Changes of fluorescence parameters of greening seedlings of seven species under drought stress Jie Li, Zhuomin Wang, Li Xue 09 Mammalian sex hormone affects regeneration capacity and enzymes activity of Triticale L in vitro culture Ismail Bezirganoglu, Pınar Uysal 10 Fractional Fourier entropy increases the recognition rate of fruit type detection Shuihua Wang, Zhihai Lu, Jiquan Yang, Yudong Zhang, John Liu, Ling Wei, Shufang Chen, Preetha Phillips, Zhengchao Dong 11 Banana-peanut intercropping reduces Fusarium wilt disease in banana from enhancing soil bacterial microorganisms and leaf nutrition Hong Li, Xutong Wang, Fengliang Zhao, Guisheng Yang 12 Manganese stress impairs stem ureide nitrogen fixation in yardlong-bean plants in the acidic environment Hong Li 13 A new pest control method for Rhytidodera bowringii Larvae Haijie Huang, Li Zhao, Weijian Huang, Jinhui Wang, Zhongrun Zhang 14 Research on the seed-like Fruits of Subg. Sclarea of

  6. Expressions and clinical significance of autophagy-related markers Beclin1, LC3, and EGFR in human cervical squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hu YF

    2015-08-01

    Full Text Available Yun-Feng Hu,1 Xia Lei,2 Hong-Yi Zhang,3 Jun-wei Ma,1 Wei-wei Yang,1 Min-lin Chen,1 Jie Cui,1,4 Hong Zhao1 1Department of Oncology, 2Department of Gynecology, 3Department of Urology, Yan’an University Affiliated Hospital, Yan’an, Shaanxi Province, People’s Republic of China; 4Department of Oncology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China Purpose: We aimed to investigate the expression of EGFR and the autophagy-related markers Beclin1 and LC3 in cervical cancer.Methods: Beclin1, LC3, and EGFR expression were analyzed in 80 samples of cervical squamous cell carcinoma (SCC, 40 samples of high-grade cervical intraepithelial neoplasia (CIN, and 40 samples of normal cervical tissues by immunohistochemistry. The protein expression rates were analyzed with χ2 and Fisher’s exact tests. Differences in overall survival (OS were determined using the Kaplan–Meier method and log-rank tests.Results: Cervical cancer, high-grade CIN, and normal cervical epithelial cells expressed Beclin1 in 26.2%, 77.5%, and 82.5% of patients, respectively, and expressed LC3 in 28.8%, 70.0%, and 75.0% of patients, respectively. There was a significant difference between cervical SCC and high-grade CIN or normal cervical epithelial cells (P=0.000. Cervical cancer cells, high-grade CIN cells, and normal cervical epithelial cells expressed EGFR in 68.8%, 62.5%, and 12.5% of patients, respectively. There was a significant difference between cervical SCC or high-grade CIN and normal cervical epithelial cells (P=0.000. No significant association between Beclin1 or LC3 or EGFR expression and various clinicopathological parameters was observed in cervical SCC. There was no significant correlation between Beclin1, LC3, EGFR expression, and 5-year OS rates of cervical SCC patients. Beclin1- or LC3-negativity with EGFR-positivity in cervical SCC was associated with a higher Federation International of

  7. Characterization of Off-Road Diesel Emissions of Criteria Pollutants

    Science.gov (United States)

    2008-10-01

    al., 2003a; Vogt et al., 2003b; Weijers et al., 2004; Westerdahl et al., 2005; Xu et al., 2007; Yao et al., 2006; Yao et al., 2007a; Yli-Tuomi et al...2993-3002. Westerdahl , D.; Fruin, S.; Sax, T.; Fine, P.M.; and Sioutas, C. (2005). Mobile platform measurements of ultrafine particles and associated

  8. Using a hybrid methodology of dasyametric mapping and data ...

    African Journals Online (AJOL)

    Mawande Ngidi

    advances in software development has led to an increase in the use of ... growth studies; public services; and resource allocation optimization (Yao Yao et al., ..... For example at a local level it has been used in a range of analyses to test for ...

  9. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences. OLIVIA X M YAO. Articles written in Proceedings – Mathematical Sciences. Volume 127 Issue 3 June 2017 pp 393-410 Research Article. New modular relations involving cubes of the Göllnitz–Gordon functions · OLIVIA X M YAO · More Details Abstract Fulltext PDF.

  10. Two new species of the spider genus Pholcus Walckenaer, 1805 (Araneae, Pholcidae from Tajikistan, with the first description of female Pholcus sidorenkoi Dunin, 1994

    Directory of Open Access Journals (Sweden)

    Tingting Dong

    2017-03-01

    Full Text Available Two new species of the genus Pholcus Walckenaer, 1805 are described from Tajikistan: Pholcus saidovi Yao & Li sp. nov. (♂♀ and P. shuguanensis Yao & Li sp. nov. (♂. The female of P. sidorenkoi Dunin, 1994 is reported for the first time. All belong to the P. nenjukovi species group.

  11. Two new species of Oobius (Hymenoptera: Encyrtidae) and their phylogenetic relationship with other congeners from northeastern Asia

    Science.gov (United States)

    Yan-Xia Yao; Jian J. Duan; Jason L. Mottern; Xiao-Yi Wang; Zhong-Qi Yang; Leah S. Bauer; Michael W. Gates

    2018-01-01

    Two new species of egg parasitoids, Oobius saimaensis Yao and Mottern new species and Oobius fleischeri Yao and Duan new species (Hymenoptera: Encyrtidae), are described from eggs of Agrilus fleischeri Obenberger, 1925 (Coleoptera: Buprestidae). Agrilus fleischeri is a phloemfeeding woodborer of poplar (...

  12. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences. Hongliang Yao. Articles written in Proceedings – Mathematical Sciences. Volume 120 Issue 2 April 2010 pp 199-207. A T -Algebras and Extensions of A T -Algebras · Hongliang Yao · More Details Abstract Fulltext PDF. Lin and Su classified A T -algebras of real rank ...

  13. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Cheng-Li Yao. Articles written in Journal of Chemical Sciences. Volume 121 Issue 1 January 2009 pp 89-93 Full Papers. Sucrose/bovine serum albumin mediated biomimetic crystallization of calcium carbonate · Cheng-Li Yao Wang-Hua Xu Ai-Min Ding Jin-Mao Zhu.

  14. Der Pelz des Hermelins oder Von Sommer- und Winterkleidern, Tarn- und Warntrachten, Putz-, Schutz- und Trutzfärbungen sowie der Jäger’schen Normalkleidung

    OpenAIRE

    Toepfer, Georg

    2018-01-01

    Der Pelz des Hermelins ist im Sommer braun und im Winter weiß. Das ist ein schönes Phänomen für sich, zumal das Weiß von einer Reinheit ist, die sich im Tierreich selten findet. Die Reinheit ihres weißen Fells wurde vielen Hermelinen zum Verhängnis: Sie endeten als Stück in einem adligen Mantel, ihr Weiß noch unterstrichen durch die schwarze Schwanzspitze, die mitverarbeitet wurde. Das reine Weiß des Winterpelzes machte das Hermelin auch zu einer brauchbaren Projektionsfläche des Volksglauben...

  15. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    International Nuclear Information System (INIS)

    Zhang, Y. P.; Liu, Yi; Yuan, G. L.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R.; Luo, X. B.; Liu, Y. Q.; Hua, Y.; Isobe, M.

    2014-01-01

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team , Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported

  16. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y. P., E-mail: zhangyp@swip.ac.cn; Liu, Yi; Yuan, G. L.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R. [Southwestern Institute of Physics, P.O. Box 432, Chengdu 610041 (China); Luo, X. B.; Liu, Y. Q.; Hua, Y. [Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610041 (China); Isobe, M. [National Institute for Fusion Science, 322-6 Oroshi-cho, Toki 509-5259 (Japan)

    2014-05-15

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team , Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported.

  17. A family-oriented treatment program for youths with ketamine abuse and their caregivers: a pilot study in Taiwan

    Directory of Open Access Journals (Sweden)

    Wang LJ

    2015-07-01

    Full Text Available Liang-Jen Wang,1 Shing-Fang Lu,1 Wen-Jiun Chou,1 Mian-Yoon Chong,2 Yao-Hsing Wang,1 Yu-Lian Hsieh,1 Yi-Hsuan Lee,1 Ching Chen2 1Department of Child and Adolescent Psychiatry, 2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Objective: The abuse of ketamine by youths has grown into a serious public health issue. However, a reliable and efficient treatment has still not been found for youths who abuse ketamine. This pilot study investigated the effects of a family-oriented treatment program for ketamine-using youths and their caregivers.Methods: To carry out this study, 42 youths with ketamine use (mean age 16.6±1.1 years who were referred to take part in a 10-week treatment program based on motivational enhancement principles were selected, as were their principal caregivers (mean age 46.4±7.1 years, who were similarly referred to take part in a 10-week training program for parenting skills. The study had the youths complete the Chinese Craving Beliefs Questionnaire, the Adolescents’ Behavior problem Scale, and the Family APGAR both immediately before and after the program. Likewise, the youths’ caregivers completed the Family APGAR, the 12-item version of the Chinese Health Questionnaire, and the Parenting Stress Index.Results: Of the 42 youth–caregiver pairs that took part in this study, 37 (88% completed the 10-week program and both sets of assessments. After the treatment, the participating youths’ substance cravings declined (t=3.88, P<0.001, while family function, as perceived by the participating caregivers, significantly increased (t=2.22, P=0.033. The improvement in caregivers’ perceptions of family function were positively related to the improvement of the caregivers’ health status (r=-0.36, P=0.022.Conclusion: According to its results, this pilot study submits that family-oriented treatment programs may be considered a potentially effective

  18. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    Science.gov (United States)

    Zhang, Y. P.; Liu, Yi; Luo, X. B.; Isobe, M.; Yuan, G. L.; Liu, Y. Q.; Hua, Y.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R.

    2014-05-01

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team, Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the α-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported.

  19. Effects of HGF gene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer

    Directory of Open Access Journals (Sweden)

    Chen HY

    2017-02-01

    Full Text Available Hai-Yong Chen,1,2 Yao-Min Chen,3 Jian Wu,1,2 Fu-Chun Yang,1,2 Zhen Lv,1,2 Yi-Gang Qian,1,2 Shu-Sen Zheng1,2 1Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 3Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China Objective: To investigate the correlations of two hepatocyte growth factor (HGF gene polymorphisms (rs5745652 and rs2074725 and their protein expression levels with the efficacy of transhepatic arterial chemotherapeutic embolism (TACE and prognosis in patients with primary liver cancer (PLC. Methods: From March 2011 to June 2012, 109 PLC patients (the case group who chose TACE as primary treatment and 80 healthy people (the control group who had undergone physical examination in The First Affiliated Hospital, Zhejiang University were selected during the same period. Gene polymorphisms of HGF rs5745652 and HGF rs2074725 were detected. Serum HGF level, treating efficacy, survival quality, and 3-year survival rate for PLC patients who received TACE were observed. Results: There were significant differences in genotype and allele frequencies of HGF rs5745652 and HGF rs2074725, between the case and control groups (all P<0.05. Compared with CT+TT genotype of HGF rs5745652, patients carrying CC genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate (all P<0.05. In rs2074725, patients carrying CA+AA genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate compared with patients carrying rs2074725 CC genotype (all P<0.05. Gene polymorphisms of HGF rs5745652 and HGF rs2074725, tumor size, and Barcelona Clinic Liver Cancer stage were independent prognostic factors for PLC (P<0.05. Conclusion: Our

  20. Projects of Earth Sciences Supported by National Natural Science Foundation of China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    -jie 40071002\tResearch into the Spatial Variation of the Effective temperature and Its Functions to Vegetation Landscape in Mountainous Areas\tJIANG Yuan 40071003\tCompilation of Coching Chu's Collected Works and Research on His Scientific Innovation Prints FAN Hong-ye 40071004\tThe Study of the Theory and Experiment on the Water Resource Demanded by the Eco-environment in Arid Region\tJIA Bao-quan 40071005\tQuantitative Analysis on the Difference of Environmental Fragile Degree under Global Change in the Two Sides of Qinling Mountains\tYAN Jun-ping 40071006\tHigh Resolution Studies of the Holocene Climatic and Hydrological Events in the Weihe River Basin\tHUANG Chun-chang 40071007\tA Land Surface Processes Coupling Model and Observation in Alpine Meadow\tYAO De-liang 40071008\tEffects of Groundwater on Land Surface Processes and Agricultural Ecology\tYU Qiang 40071009\tStudy on the Relationship Between Vegetation Change and Main Hydraulic Process in the Oasis-Desert Ecotone\tZHAO Cheng-yi 40071010\tExperimental Research on Stress Constitutive Relation of Debris Flow in the Field\tWANG Yu-yi 40071011\tFrom a Longitudinal Section to Research the Environmental Change during the Late Quaternary in the Inland of South China Tropical Zone\tHUANG Zhen-guo 40071012\tRelations Between Dune Lee-side Cross-bedding, Morphology, and Different Scale of Air-flow\tHA Si 40071013\tFormation Mechanism and Evolution Processes of Flood Channels in the Changjiang Estuary\tSHEN Huan-ting 40071014\tThe Beach Changes under Wave Action on Tidal Coastal Area\tBAO Si-lin 40071015\tEvolution of Glaciers and Monsoon during the Last Glaciation in the Gongwang Mountain of Yunnan and Yu Mountain of Taiwan\tCUI Zhi-jiu 40071016\tGeomorphic Variation Model of the Yellow River Between the Hukou Fall and the Xiaolangdi Reservoir\tLI You-li 40071017\tStudy on Coupling of Karst Surface and Subsurface (Cave) Ecologic and Environment Systems and Speleothem Scenic Stability\tSONG Lin-hua 40071018\tWind Tunnel

  1. Retrospective study of irinotecan/cisplatin followed by etoposide/cisplatin or the reverse sequence in extensive-stage small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Xiao XG

    2015-08-01

    Full Text Available Xiaoguang Xiao, Shujing Wang, Shu Xia, Man Zou, Yang Li, Yao Wei, Qi Mei, Yuan Chen Department of Oncology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of China Background: Much research has confirmed the favorable effect of irinotecan/cisplatin (IP and etoposide/cisplatin (EP on extensive-stage small cell lung cancer (E-SCLC. This study investigated two sequential orders of IP and EP in the treatment of E-SCLC. We also compared the efficacy and safety of IP and EP in first-line chemotherapy in E-SCLC. Methods: Ninety-three untreated patients with E-SCLC were randomly allocated to two groups. Group A received IP as first-line therapy until progression and then changed to EP; group B received EP as first-line therapy until tumor progression followed by IP. The primary endpoints were overall survival and time to second tumor progression. The secondary endpoints were first progression-free survival (PFS, ie, time from randomization to first occurrence of tumor progression after first-line treatment with IP or EP, tumor response, and safety of the different sequential treatment orders of IP and EP. Results: Median overall survival was 15.4 months in group A (IP followed by EP versus 15.7 months in group B (EP followed by IP; P=0.483. The median time to second tumor progression was 9.5 months in group A versus 9.9 months in group B (P=0.361. As first-line and second-line therapy, IP achieved a 95.9% and 60% disease control rate, respectively, and EP achieved 95.6% and 59% disease control rate. The median first PFS was not significantly different between group A and group B (6.5 months and 6.3 months, respectively; P=0.256. Grade 3/4 diarrhea appeared to be significantly more frequent with IP than with EP. The probability of anemia and thrombocytopenia was not significantly different between the two groups. However, significantly more patients who received the IP regimen as

  2. In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration

    Directory of Open Access Journals (Sweden)

    Fang M

    2012-10-01

    Full Text Available Min Fang, Yilin Jin, Wei Bao, Hui Gao, Mengjin Xu, Di Wang, Xia Wang, Ping Yao, Liegang LiuDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, People’s Republic of ChinaBackground: Curcumin has a variety of pharmacological effects. However, poor water solubility and low oral bioavailability limit its clinical utility. A delivery system for nanostructured lipid carriers has been reported to be a promising approach to enhancing the oral absorption of curcumin. The aim of the present study was to investigate the pharmacokinetics, tissue distribution, and relative bioavailability of curcumin in rats after a single intragastric dose of a nanostructured lipid curcumin carrier formulation.Methods: Nanostructured lipid curcumin carriers were prepared using the ethanol dripping method and characterized in terms of the particle size, polydispersity index, zeta potential, differential scanning calorimetry, drug-loading capacity, encapsulation efficiency, and in vitro release. The pharmacokinetics and tissue distribution of nanostructured lipid curcumin carriers and curcumin suspension were compared after intragastric administration.Results: Nanostructured lipid curcumin carriers showed a significantly higher peak plasma concentration (564.94 ± 14.98 ng/mL versus 279.43 ± 7.21 ng/mL, P < 0.01, a shorter time taken to reach peak plasma concentration (0.5 ± 0.01 hour versus 1.0 ± 0.12 hour, P < 0.01, and a greater AUC0–∞ (820.36 ± 25.11 mg × hour/L versus 344.11 ± 10.01 mg × hour/L, P < 0.05 compared with curcumin suspension. In the tissue distribution studies, curcumin could be detected in the spleen, heart, liver, kidneys, lungs, and brain. Following intragastric administration of the nanostructured lipid curcumin

  3. Identification of key genes and pathways associated with neuropathic pain in uninjured dorsal root ganglion by using bioinformatic analysis

    Directory of Open Access Journals (Sweden)

    Chen CJ

    2017-11-01

    Full Text Available Chao-Jin Chen,* De-Zhao Liu,* Wei-Feng Yao, Yu Gu, Fei Huang, Zi-Qing Hei, Xiang Li Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Purpose: Neuropathic pain is a complex chronic condition occurring post-nervous system damage. The transcriptional reprogramming of injured dorsal root ganglia (DRGs drives neuropathic pain. However, few comparative analyses using high-throughput platforms have investigated uninjured DRG in neuropathic pain, and potential interactions among differentially expressed genes (DEGs and pathways were not taken into consideration. The aim of this study was to identify changes in genes and pathways associated with neuropathic pain in uninjured L4 DRG after L5 spinal nerve ligation (SNL by using bioinformatic analysis.Materials and methods: The microarray profile GSE24982 was downloaded from the Gene Expression Omnibus database to identify DEGs between DRGs in SNL and sham rats. The prioritization for these DEGs was performed using the Toppgene database followed by gene ontology and pathway enrichment analyses. The relationships among DEGs from the protein interactive perspective were analyzed using protein–protein interaction (PPI network and module analysis. Real-time polymerase chain reaction (PCR and Western blotting were used to confirm the expression of DEGs in the rodent neuropathic pain model.Results: A total of 206 DEGs that might play a role in neuropathic pain were identified in L4 DRG, of which 75 were upregulated and 131 were downregulated. The upregulated DEGs were enriched in biological processes related to transcription regulation and molecular functions such as DNA binding, cell cycle, and the FoxO signaling pathway. Ctnnb1 protein had the highest connectivity degrees in the PPI network. The in vivo studies also validated that mRNA and protein levels of Ctnnb1 were

  4. Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells

    Directory of Open Access Journals (Sweden)

    Chang YT

    2017-07-01

    Full Text Available Yung-Ting Chang,1,2,* Chiung-Yao Huang,3,* Jen-Yang Tang,4,5 Chih-Chuang Liaw,1,3 Ruei-Nian Li,6 Jing-Ru Liu,6 Jyh-Horng Sheu,1,3,7,8 Hsueh-Wei Chang6,9–12 1Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan; 2Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei, Taiwan; 3Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan; 4Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 6Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan; 7Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; 8Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 9Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 10Cancer Center, Kaohsiung Medical University Hospital; Kaohsiung Medical University, Kaohsiung, Taiwan; 11Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 12Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. The functional role of oxidative stress in the cell-killing effect of sinuleptolide on oral cancer cells was not investigated as yet. To address this question, we introduced the reactive oxygen species (ROS scavenger (N-acetylcysteine [NAC] in a pretreatment to evaluate the sinuleptolide-induced changes to cell viability, morphology, intracellular

  5. Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs

    Directory of Open Access Journals (Sweden)

    Wang CL

    2015-05-01

    Full Text Available Chunling Wang,1 Xiaobo Cheng,2 Yuqing Su,1 Ying Pei,3 Yanzhi Song,1 Jiao Jiao,1 Zhenjun Huang,1 Yanfei Ma,1 Yinming Dong,1 Ying Yao,1 Jingjing Fan,1 Han Ta,1 Xinrong Liu,1 Hui Xu,1 Yihui Deng1 1College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; 2Deli Wei Biological Technology Co, Ltd, Beijing, People’s Republic of China; 3Shenyang Women’s and Children’s Hospital, Shenyang, People’s Republic of China Abstract: The cross-administration of nanocarriers modified by poly(ethylene glycol (PEG, named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resistance, and increase therapeutic efficacy. However, repeated injections of PEGylated nanocarriers induces the accelerated blood clearance (ABC phenomenon, prevents long circulation, and can cause adverse effects owing to alterations in the biodistribution of the drug. Although the nature of the ABC phenomenon that is induced by repeated injections of PEGylated nanocarriers has already been studied in detail, there are few reports on the immune response elicited by the cross-administration of PEGylated nanocarriers. In this study, we investigated the ABC phenomenon induced by the intravenous cross-administration of various PEGylated nanocarriers, including PEGylated liposomes (PL, PEG micelles (PM, PEGylated solid lipid nanoparticles (PSLN, and PEGylated emulsions (PE, in beagle dogs. The results indicated that the magnitude of the immune response elicited by the cross-administration was in the following order (from the strongest to the weakest: PL, PE, PSLN, PM. It is specifically PEG in the brush structure that elicits a significant immune response, in both the induction phase and the effectuation phase. Furthermore, the present study suggests that there is a considerable difference between the effect of repeated injections and

  6. Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

    Directory of Open Access Journals (Sweden)

    Li CR

    2015-10-01

    Full Text Available Cheng-Rang Li, Qiu-Xia Mao, Min Chen, Wei-Xue Jia, Xu Yao, Su-Ying Feng, Hong Jia, Juan-Qin Gong, Xue-Yuan Yang Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, People’s Republic of China Background: TNF-α plays a key role in host defense against mycobacterial infection, and patients receiving TNF-α blocker treatment have increased susceptibility to tuberculosis disease. In the People’s Republic of China, an intermediate tuberculosis-burden country, the latent tuberculosis infection (LTBI risk in patients with psoriasis who are treated with etanercept, the safest kind of TNF-α blocker, is unknown.Objectives: This study reports the LTBI risk in patients with psoriasis after etanercept treatment and aims to answer the question of how often rescreening for LTBI should be done in order to reduce active tuberculosis infection of patients and further reduce the incidence of active tuberculosis disease.Patients and methods: This retrospective review evaluated patients with moderate-to-severe chronic plaque psoriasis between 2009 and 2013. All patients were excluded tuberculosis infection and received etanercept 25 mg twice weekly, then the patients were checked for LTBI 3 months after etanercept treatment to observe the incidence of LTBI and assess the need for rescreening for LTBI every 3 months.Results: We retrospectively analyzed 192 patients with psoriasis with moderate-to-severe chronic plaque whose tuberculin skin test and chest X-rays were negative and who received etanercept 25 mg twice weekly. Eighteen of them were excluded because they received less than 3 months of etanercept therapy. After treatment with etanercept, four patients were found to have LTBI.Conclusion: In this study, the incidence of LTBI after 3 months was four in 192 (2.1%, which is higher than the annual incidence of LTBI in the People’s Republic of China (0.72%, so LTBI could be expected to occur

  7. Enhancing the bioactivity of Poly(lactic-co-glycolic acid scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model

    Directory of Open Access Journals (Sweden)

    Wang DX

    2013-05-01

    Full Text Available De-Xin Wang,1,* Yao He,2,* Long Bi1,* Ze-Hua Qu,2 Ji-Wei Zou,1 Zhen Pan,2 Jun-Jun Fan,1 Liang Chen,2 Xin Dong,1 Xiang-Nan Liu,2 Guo-Xian Pei,1 Jian-Dong Ding,21Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China; 2State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, People's Republic of China*These authors contributed equally to this workPurpose: Poly(lactic-co-glycolic acid (PLGA is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keeping the polyester skeleton of the scaffolds.Methods: PLGA porous scaffolds were prepared and surface modification was carried out by incubation in modified simulated body fluids. The nHA coated PLGA scaffolds were compared to the virgin PLGA scaffolds both in vitro and in vivo. Viability and proliferation rate of bone marrow stromal cells of rabbits were examined. The constructs of scaffolds and autogenous bone marrow stromal cells were implanted into the segmental bone defect in the rabbit model, and the bone regeneration effects were observed.Results: In contrast to the relative smooth pore surface of the virgin PLGA scaffold, a biomimetic hierarchical nanostructure was found on the surface of the interior pores of the nHA coated PLGA scaffolds by scanning electron microscopy. Both the viability and proliferation rate of the cells seeded in nHA coated PLGA scaffolds were higher than those in PLGA scaffolds. For bone defect repairing, the radius defects had, after 12 weeks implantation of nHA coated PLGA scaffolds, completely recuperated with significantly better bone formation than in

  8. Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats

    Directory of Open Access Journals (Sweden)

    Chen HH

    2015-03-01

    Full Text Available Hwei-Hsien Chen,1,2,* Yao-Chang Chiang,3,4,* Zung Fan Yuan,5,6 Chung-Chih Kuo,5,6 Mei-Dan Lai,2 Tsai-Wei Hung,1 Ing-kang Ho,1,3,4 Shao-Tsu Chen2,7 1Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan; 2Master and PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan; 3Center for Drug Abuse and Addiction, China Medical University Hospital, 4Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; 5Master Program in Physiological and Anatomical Medicine, 6Department of Physiology, School of Medicine, Tzu Chi University, 7Department of Psychiatry, Buddhist Tzu Chi General Hospital, Hualien, Taiwan *These authors contributed equally to this work Abstract: Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This study aimed at comparing the behavioral outcomes of young rats prenatally exposed to buprenorphine, methadone, and morphine. Pregnant Sprague-Dawley rats were administered saline, morphine, methadone, and buprenorphine during embryonic days 3–20. The cognitive function, social interaction, anxiety-like behaviors, and locomotor activity of offsprings were examined by novel object recognition test, social interaction test, light–dark transition test, elevated plus-maze, and open-field test between 6 weeks and 10 weeks of age. Prenatal exposure to methadone and buprenorphine did not affect locomotor activity, but significantly impaired novel object recognition and social interaction in both male and female offsprings in the same manner as morphine. Although prenatal exposure to methadone or buprenorphine increased anxiety-like behaviors in the light–dark transition in both male and female

  9. Bioinformatics analysis of differentially expressed proteins in prostate cancer based on proteomics data

    Directory of Open Access Journals (Sweden)

    Chen C

    2016-03-01

    Full Text Available Chen Chen,1 Li-Guo Zhang,1 Jian Liu,1 Hui Han,1 Ning Chen,1 An-Liang Yao,1 Shao-San Kang,1 Wei-Xing Gao,1 Hong Shen,2 Long-Jun Zhang,1 Ya-Peng Li,1 Feng-Hong Cao,1 Zhi-Guo Li3 1Department of Urology, North China University of Science and Technology Affiliated Hospital, 2Department of Modern Technology and Education Center, 3Department of Medical Research Center, International Science and Technology Cooperation Base of Geriatric Medicine, North China University of Science and Technology, Tangshan, People’s Republic of China Abstract: We mined the literature for proteomics data to examine the occurrence and metastasis of prostate cancer (PCa through a bioinformatics analysis. We divided the differentially expressed proteins (DEPs into two groups: the group consisting of PCa and benign tissues (P&b and the group presenting both high and low PCa metastatic tendencies (H&L. In the P&b group, we found 320 DEPs, 20 of which were reported more than three times, and DES was the most commonly reported. Among these DEPs, the expression levels of FGG, GSN, SERPINC1, TPM1, and TUBB4B have not yet been correlated with PCa. In the H&L group, we identified 353 DEPs, 13 of which were reported more than three times. Among these DEPs, MDH2 and MYH9 have not yet been correlated with PCa metastasis. We further confirmed that DES was differentially expressed between 30 cancer and 30 benign tissues. In addition, DEPs associated with protein transport, regulation of actin cytoskeleton, and the extracellular matrix (ECM–receptor interaction pathway were prevalent in the H&L group and have not yet been studied in detail in this context. Proteins related to homeostasis, the wound-healing response, focal adhesions, and the complement and coagulation pathways were overrepresented in both groups. Our findings suggest that the repeatedly reported DEPs in the two groups may function as potential biomarkers for detecting PCa and predicting its aggressiveness. Furthermore

  10. 專論/論搜尋引擎以程式在網路上自動抓取資料時可能面臨之法律問題及其解決之道/廖先志;陳鍾誠 | The Possible Legal Issues about Crawlers and Their Resolutions/ Hsien-Jyh Liao;Yi-Hsuan Lin

    Directory of Open Access Journals (Sweden)

    廖先志、陳鍾誠

    2007-04-01

    Full Text Available

    搜尋引擎必須以Crawler程式(又稱spider程式)來自動抓取網頁並建立索引,如果Crawler程式僅僅循著網頁所提供的超連結來搜尋網 頁並抓取內容,稱為一般性的Crawler程式:如果不論網頁是否提供超連結,Crawler程式會自行計算並找到網頁的所有內容並加以抓取,此種 Crawler則稱為深度Crawler。而Crawler抓取網頁內容的步驟可以細分為「取得資料」及「儲存並建立索引」二大步驟。在「取得資料」階段 中,深度Crawler雖然是自行透過演算法來取得網頁的所有內容,但本文認為仍不至於構成非法存取(unauthorized access。此外,不論是一般的Crawler或是深度Crawler,如果取得網頁內容時會耗費網站資源而干擾網站的正常運作,就可能構成如美國 eBdy案中討論的財產侵害(trespass to chattel。在「儲存並建立索引」階段中,原則上應該不會侵害網頁擁有者之重製權,然而、有些搜尋引擎(例如Google將其取得的內容以「庫存 頁面」( Cache的方式允許使用者存取,此時即有爭議發生,但本文以為,由於搜尋引擎的主要目的是在使網路使用者更容易接觸網頁,所以此種「重製」與「散布」 行為原則上應有著作權法「合理使用」原則的適用,故不會構成侵害著作權,但仍應考慮搜尋引擎與原網站之間是否處於競爭關係,以及所抓取之資料量佔原網站之 比例等因素綜合判斷。要解決搜尋引擎與網站間可能發生的法律爭議,除可以強化現行的robot exclusion標準外,網站也可以考慮增強自動過濾Crawler的功能,以杜絕爭議。


    A Search engine uses a crawler (or a spider to retrieve and index web pages. A “general crawler” crawls across the Internet by following only the hyperlinks directly provided by web pages. On the other hand, a “deep crawler” has the capability of retrieving all contents of web pages whether the hyperlinks are available or not. The process of a crawler’s work can be split into two major steps: the “retrieving” step and the “storage and indexing” step. As far as the retrieving step is concerned, even though a deep crawler can generate all URLs by itself, there should not be any unauthorized access at all. However, a crawler, either a general or deep one, will be charged with trespassing to chattel if it interferes in the website, whereas, in the “storage and indexing” step, owners’ copyright of web pages will in principle not be infringed upon by a crawler. Nevertheless, there are controversies about “cache”, which is provided by certain popular search engines, such as Google and Yahoo. Search engines may claim their fair use defense of “cache”, because one of the main goals of search engines is to improve access to information on the internet. Actually, we must consider many factors before we decide whether “cache” is fair or not, for instance, whether there is competition between the search engine and the retrieved web sites; and what percentage of the contents is retrieved by the crawler, etc. To resolve all possible legal conflicts between crawlers and web pages, among several economic resolutions, a newer and complete robot exclusion standard is required. In addition, a self-detecting mechanism adopted by web pages may be even a more powerful one.

    頁次:53-66

  11. 从“辽燕旧界”到“华夷大界”——朝鲜人笔下的山海关意象%From "the Boundary Beween Liao and Yan" to "the Boundary Beween Hua and Yi" : Shanhaiguan as Described by Koreans in the Ming and Qing Dynasties

    Institute of Scientific and Technical Information of China (English)

    黄普基

    2012-01-01

    明朝时期,朝鲜人并无以山海关为界、关内外华夷不同的“分界”概念。但明清易代,政治局面的巨变促使朝鲜人大大地强化了华夷分界的意识,以致最终认定山海关为明晰的“界线”。具体而言,清时期朝鲜人对关内的种种自然、人文景观往往表现出令人惊叹的宽容和肯定;相反,对关外却持着过于苛刻的否定态度。然而,有趣的是,清时期朝鲜人对关内外分界意识逐渐强化之时,两地的文化差距实际上却在日益缩小。而且,关内永平府与关外辽西之间,其相似性甚至大于差异性。%The concept that Shanhaiguan was the boundary between Chinese and foreigners did not exist at all among Koreans in the Ming Dynasty, but the concept was greatly strengthened but great political changes during the Ming-Qing transition. Koreans was surprisingly tolerant and positive towards the natural and humane landscape inside the Pass, but was overly severe and negative towards the landscape outside the Pass in the Qing Dynasty. Interestingly, the cultural distinction between inside the Pass and outside the Pass was reduced day by day while the boundary conception was gradually being strengthened in the Qing Dynasty, even though the resemblance was more than the distinction between inside the Pass and outside the Pass.

  12. Comment on “Observations of ammonia, nitric acid, and fine particles in a rural gas production region” by Yi Li, Florian M. Schwandnera, H. James Sewell, Angela Zivkovich, Mark Tigges, Suresh Raja, Stephen Holcomb, John V. Molenar, Lincoln Sherman, Cassie Archuleta, Taehyoung Lee and Jeffrey L. Collett Jr. Atmospheric Environment (in press)

    Science.gov (United States)

    Phillips, Gavin J.

    2014-05-01

    An artefact of the detection of nitric acid (HNO3) by denuder methods is discussed. This artefact arises from the likely reaction of dinitrogen pentoxide (N2O5) on the denuder train resulting in the report of some fraction of N2O5 as HNO3.

  13. Effect of HALS and antioxidant on the radiation-induced discoloration of polypropylene

    International Nuclear Information System (INIS)

    Wang Huiliang; Kong Xiangbo; Chen Wenxiu

    1999-01-01

    The effects of hindered amine light stabilizers (HALS), antioxidants and the combination of HALS and antioxidants on the radiation-induced discoloration of polypropylene (PP) are studied. The yellow index (YI) of PP added pentamethyl HALS is found to be lower than that of PP added corresponding tetramethyl HALS at the same radiation dose. The YI of PP added antioxidant Irganox 1076 is lower than that of PP added Irgafos 168 or Irganox PS-802. When Irganox 1076 and PDS are used together, the YI of PP is lower than that of Irganox 1076 or PDS used separately. YI of PP decreases with storage time after irradiation. The results are discussed

  14. A non-LEA sofic group

    Indian Academy of Sciences (India)

    ADITI KAR

    show that the class of LEA groups is not closed under taking free products with infinite cyclic amalgamations. c Indian ... Note that Yi/Z is a divisible group and so Yi = (Yi ∩ H )Z giving that [Y1 : (Y1 ∩ H)] = [Z: (Z ∩ H)] = [Y2 : (Y2 ∩ H)] = a, say. The integer a is coprime to p and H ∩ Yi = fi ◦ y(aZ[ 1 p ]). Define βi = fi(y(a p. )) ...

  15. Lower expressed miR-198 and its potential targets in hepatocellular carcinoma: a clinicopathological and in silico study

    Directory of Open Access Journals (Sweden)

    Huang WT

    2016-08-01

    Full Text Available Wen-Ting Huang,1,* Han-Lin Wang,1,* Hong Yang,2 Fang-Hui Ren,1 Yi-Huan Luo,1 Chun-Qin Huang,1 Yue-Ya Liang,1 Hai-Wei Liang,1 Gang Chen,1 Yi-Wu Dang1 1Department of Pathology, 2Department of Ultrasonography, First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China *These authors contributed equally to this work Purpose: To investigate the clinicopathological value and potential roles of microRNA-198 (miR-198 in hepatocellular carcinoma (HCC.Methods: Ninety-five formalin-fixed paraffin-embedded HCC and the para-cancerous liver tissues were gathered. Real-time reverse transcription quantitative polymerase chain reaction was applied to determine the miR-198 expression. The association between the miR-198 expression and clinicopathological features was examined. Meanwhile, potential target messenger RNAs of miR-198 in HCC were obtained from 14 miRNA prediction databases and natural language processing method, in which we pooled the genes related to the tumorigenesis and progression of HCC and classified them by their frequency. The selected target genes were finally analyzed in the Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway.Results: miR-198 expression was significantly lower in HCC than that in adjacent noncancerous liver tissues (1.30±0.72 vs 2.01±0.58, P<0.001. Low miR-198 expression was also correlated to hepatitis C virus infection (r=-0.48, P<0.001, tumor capsular infiltration (r=-0.43, P<0.001, metastasis (r=-0.26, P<0.010, number of tumor nodes (r=-0.25, P=0.013, vaso-invasion (r=-0.24, P=0.017, and clinical tumor node metastasis stage (r=-0.23, P=0.024. Altogether, 1,048 genes were achieved by the concurrent prediction from at least four databases and natural language processing indicated 1,800 genes for HCC. Further, 127 overlapping targets were further proceeded with for pathway analysis. The most enriched Gene Ontology terms in the potential target messenger RNAs of mi

  16. Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C

    Directory of Open Access Journals (Sweden)

    Tseng CW

    2016-03-01

    Full Text Available Chih-Wei Tseng,1,2 Ting-Tsung Chang,3,4 Shinn-Jia Tzeng,5 Yu-Hsi Hsieh,1,2 Tsung-Hsing Hung,1,2 Hsiang-Ting Huang,6 Shu-Fen Wu,7 Kuo-Chih Tseng1,2 1Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, 2School of Medicine, Tzuchi University, Hualien, 3Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, 4Infectious Disease and Signaling Research Center, National Cheng Kung University, Tainan, 5Department of Agronomy, National Chiayi University, 6Department of Nursing, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 7Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan Objective: We studied the effect of sustained virologic response (SVR after treatment with pegylated-interferon (PEG-IFN plus ribavirin on the development of liver cirrhosis in elderly patients with chronic hepatitis C (CHC. Patients and methods: This retrospective study enrolled 145 elderly CHC patients (aged ≥65 years who were treatment-naïve and were treated with PEG-IFN plus ribavirin for 6 months between January 2005 and December 2011. Abdominal sonography was performed and liver biochemistry was studied at baseline, at the end of treatment, and every 3–6 months thereafter. The development of liver cirrhosis and related complications was evaluated at the follow-ups. The aspartate aminotransferase-to-platelet ratio index was used as a noninvasive maker for fibrosis. Results: The mean patient age was 69.1±3.3 years, and the average follow-up time was 5.5 years (standard deviation: 2.5 years, range: 1.1–12.3 years. Ninety-five patients (65.5% achieved SVR, and 26 (17.9% discontinued treatment. Twenty-seven patients (18.6% developed liver cirrhosis after treatment. Patients without SVR had significantly greater risk of liver cirrhosis than those with SVR (hazard ratio [HR]: 3.39, 95% confidence interval [CI]: 1.312–8.761, P=0.012. The

  17. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

    Directory of Open Access Journals (Sweden)

    Chen TY

    2015-03-01

    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  18. Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

    Directory of Open Access Journals (Sweden)

    Chang CW

    2018-05-01

    Full Text Available Chi-Wei Chang,1,* Chun-Nan Yeh,2,* Yi-Hsiu Chung,3,* Yong-Ren Chen,4 Shi-Wei Tien,4 Tsung-Wen Chen,2 Shiou-Shiow Farn,4,5 Ying-Cheng Huang,6 Chung-Shan Yu4,7 1Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 2Department of Surgery, Liver Research Center, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan; 3Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan; 5Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan; 6Department of Neurosurgery, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan; 7Institute of Nuclear Engineering and Science, National Tsinghua University, Hsinchu, Taiwan *These authors contributed equally to this work Background: An 18F-tagged NSAID analog was prepared for use as a probe for COX-2 expression, which is associated with tumor development. Methods: The in vivo uptake of celecoxib was monitored with ortho-[18F]fluorocelecoxib using positron emission tomography (PET. The binding affinity of ortho-[18F]fluorocelecoxib to COX-1 and COX-2 enzymes were assessed using the competitor celecoxib. Results: The IC50 values were 0.039 μM and 0.024 μM, respectively. A selectivity index of 1.63 was obtained (COX-2 vs COX-1. COX-2 overexpressed cholangiocarcinoma (CCA murine cells took up more ortho-[18F]fluorocelecoxib than that by usual CCA cells from 10 to 60 minutes post incubation. Competitive inhibition (blocking of the tracer uptake of ortho-[18F]fluorocelecoxib in the presence of celecoxib by the COX-2 overexpressed CCA cells and the usual CCA cells gave the IC50 values of 0.5 μM and 46.5 μM, respectively. Based on the in vitro accumulation data and in vivo metabolism half-life (30 min, PET scanning was performed 30–60 min after the

  19. Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating

    Directory of Open Access Journals (Sweden)

    Dong F

    2013-04-01

    Full Text Available Fuxia Dong,1,2 Yunchang Xie,1 Jianping Qi,1 Fuqiang Hu,3 Yi Lu,1 Sanming Li,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, Shanghai, People’s Republic of China; 2School of Pharmacy, Shenyang Pharmaceutical University, Liaoning, People’s Republic of China; 3School of Pharmacy, Zhejiang University, Hangzhou, People’s Republic of China Abstract: Bile salt/phospholipid mixed micelles (MMs are potent carriers used for oral absorption of drugs that are poorly soluble in water; however, there are many limitations associated with liquid formulations. In the current study, the feasibility of preparing bile salt/phospholipid MM precursor (preMM pellets with high oral bioavailability, using fluid-bed coating technology, was examined. In this study, fenofibrate (FB and sodium deoxycholate (SDC were used as the model drug and the bile salt, respectively. To prepare the MMs and to serve as the micellular carrier, a weight ratio of 4:6 was selected for the sodium deoxycholate/phospholipids based on the ternary phase diagram. Polyethylene glycol (PEG 6000 was selected as the dispersion matrix for precipitation of the MMs onto pellets, since it can enhance the solubilizing ability of the MMs. Coating of the MMs onto the pellets using the fluid-bed coating technology was efficient and the pellets were spherical and intact. MMs could be easily reconstituted from preMM pellets in water. Although they existed in a crystalline state in the preMM pellets, FB could be encapsulated into the reconstituted MMs, and the MMs were redispersed better than solid dispersion pellets (FB:PEG = 1:3 and Lipanthyl®. The redispersibility of the preMM pellets increased with the increase of the FB/PEG/micellar carrier. PreMM pellets with a FB:PEG:micellar carrier ratio of 1:1.5:1.5 showed 284% and 145% bioavailability relative to Lipanthyl® and solid dispersion pellets (FB:PEG = 1:3, respectively. Fluid

  20. Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems

    Directory of Open Access Journals (Sweden)

    Wang K

    2014-10-01

    Full Text Available Kai Wang,1–3 Jianping Qi,1 Tengfei Weng,1,2 Zhiqiang Tian,1 Yi Lu,1 Kaili Hu,4 Zongning Yin,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education, Shanghai, People’s Republic of China; 2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Tropical Crops Genetic Resources Institute, Hainan Provincial Engineering Research Center for Blumea Balsamifera, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan, People’s Republic of China; 4Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaAbstract: A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid (PLGA nanoparticles (NPs to highlight the importance of the lipid composition, with cyclosporine A (CyA as a model drug. CyA-loaded PLGA NPs, nanostructured lipid carriers (NLCs, and self-microemulsifying drug-delivery systems (SMEDDS were prepared. The particle size of PLGA NPs (182.2±12.8 nm was larger than that of NLCs (89.7±9.0 nm and SMEDDS (26.9±1.9 nm. All vehicles are charged negatively. The entrapment efficiency of PLGA NPs and NLCs was 87.6%±1.6% and 80.3%±0.6%, respectively. In vitro release tests indicated that the cumulative release of CyA was lower than 4% from all vehicles, including Sandimmun Neoral®, according to the dialysis method. Both NLCs and SMEDDS showed high relative oral bioavailability, 111.8% and 73.6%, respectively, after oral gavage administration to beagle dogs, which was not statistically different from commercial Sandimmun Neoral®. However, PLGA NPs

  1. Influence of CFH gene on symptom severity of schizophrenia

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    Zhang C

    2017-03-01

    Full Text Available Chen Zhang,1 Qinyu Lv,1 Weixing Fan,2 Wei Tang,3 Zhenghui Yi1 1Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 2Department of Psychiatry, Jinhua Second Hospital, Jinhua, 3Department of Psychiatry, Wenzhou Kanging Hospital, Wenzhou, People’s Republic of China Objective: Recent advances have provided compelling evidence for the role of excessive complement activity in the pathophysiology of schizophrenia. In this study, we aimed to detect the association of the gene encoding complement factor H (CFH, a regulator in complement activation, with schizophrenia. Materials and methods: A sample of 1783 individuals with or without schizophrenia was recruited for genetic analysis. Genomic DNA samples were extracted from peripheral blood cells using multiplex polymerase chain reaction and the SNaPshot assay. A Database for Schizophrenia Genetic Research (SZDB was used to detect the association of brain CFH expression with schizophrenia. Next, we performed a genotype–phenotype analysis to identify the relationship between CFH Y402H polymorphism and clinical features of schizophrenia. Results: There was a significant association of hippocampal CFH expression with schizophrenia (P=0.017, whereas this significance did not survive after adjusting for false discovery rate (P=0.105. Comparing the genotype and allele frequencies of the genotyped single-nucleotide polymorphisms between case and control groups showed no significant difference. There were significant differences in the scores of negative symptoms and delayed memory between the patients with C allele and those without C allele (P<0.01 and P=0.04 after Bonferroni correction, respectively. Furthermore, we observed a marginally significant association between the Y402H polymorphism and CFH expression in the hippocampus (P=0.051; however, this significance was lost after multiple testing correction (P=0.51, after Bonferroni correction

  2. Comparison of safety and outcomes of shock wave lithotripsy between elderly and non-elderly patients

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    Chen YZ

    2017-04-01

    Full Text Available Yi-Zhong Chen,1 Wun-Rong Lin,1,2 Chih-Chiao Lee,1,2 Fang-Ju Sun,1,3 Yung-Chiong Chow,1,2 Wei-Kung Tsai,1,2 Pai-Kai Chiang,1,2 Ting-Po Lin,1,2 Marcelo Chen,1–3 Allen W Chiu1,4 1Department of Urology, MacKay Memorial Hospital, 2School of Medicine, MacKay Medical College, 3Department of Cosmetic Applications and Management, MacKay Junior College of Medicine, Nursing and Management, 4School of Medicine, National Yang-Ming University, Taipei, Taiwan Background: This study compared the clinical outcomes of extracorporeal shock wave lithotripsy between elderly (aged ≥65 years and non-elderly (aged <65 years patients.Methods: A retrospective review of medical records was performed on 483 (non-elderly: 245, elderly: 238 patients with upper urinary tract stones who underwent shock wave lithotripsy between 2007 and 2015. The demographic data, stone parameters, stone-free rate, retreatment rate, and complication rate were analyzed in both elderly and non-elderly patient groups.Results: There was no significant difference between non-elderly and elderly patients in terms of stone-free rate (46.5% vs 41.1%, P>0.05 regardless of stone site or stone size and overall retreatment rate (41.6% vs 37.0%, P>0.05. Elderly patients had a higher complication rate than non-elderly patients (15.5% vs 23.5%, P=0.026. The most common complication was flank pain. Receiver operating characteristic curves predicted that elderly patients (cutoff value: 65 years of age had a higher risk of complications and that patients with smaller stones (cutoff value: 0.8 cm had a higher stone-free rate.Conclusion: This study showed that elderly patients with upper urinary tract stones undergoing shock wave lithotripsy had comparable efficacy for stone-free rates and retreatment rates, but higher complication rates. Keywords: elderly, shock wave lithotripsy, upper urinary tract stone, safety, outcome

  3. Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

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    Li HF

    2015-06-01

    Full Text Available Huai-Feng Li,1–3,* Xu-An Wang,1–3,* Shan-Shan Xiang,1–3,* Yun-Ping Hu,1–3 Lin Jiang,1–3 Yi-Jun Shu,1–3 Mao-Lan Li,1–3 Xiang-Song Wu,1–3 Fei Zhang,1–3 Yuan-Yuan Ye,1–3 Hao Weng,1–3 Run-Fa Bao,1–3 Yang Cao,1–3 Wei Lu,1–3 Qian Dong,1–3 Ying-Bin Liu1–3 1Department of General Surgery, 2Laboratory of General Surgery, 3Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Oleanolic acid (OA, a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor prognosis. Unfortunately, the effects of OA on gallbladder carcinoma are unknown. In this study, we investigated the effects of OA on gallbladder cancer cells and the underlying mechanism. The results showed that OA inhibits proliferation of gallbladder cancer cells in a dose-dependent and time-dependent manner on MTT and colony formation assay. A flow cytometry assay revealed apoptosis and G0/G1 phase arrest in GBC-SD and NOZ cells. Western blot analysis and a mitochondrial membrane potential assay demonstrated that OA functions through the mitochondrial apoptosis pathway. Moreover, this drug inhibited tumor growth in nude mice carrying subcutaneous NOZ tumor xenografts. These data suggest that OA inhibits proliferation of gallbladder cancer cells by regulating apoptosis and the cell cycle process. Thus, OA may be a promising drug for adjuvant chemotherapy in gallbladder carcinoma. Keywords: oleanolic acid, gallbladder carcinoma, apoptosis, cell cycle arrest, mitochondrial pathway

  4. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Science.gov (United States)

    Ahn, Sang-Hyeon

    2009-12-01

    We investigated the formation of Pochonka (Song of the Sky Pacers) and Chonmun yucho (Selected and classified writings on astrology) of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contents of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson's Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson's Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson's Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern) published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts that Choson

  5. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Directory of Open Access Journals (Sweden)

    Sang-Hyeon Ahn

    2009-12-01

    Full Text Available We investigated the formation of Pochonka (Song of the Sky Pacers and Chonmun yucho (Selected and classified writings on astrology of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contnts of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson`s Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson`s Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson`s Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts

  6. Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer

    Directory of Open Access Journals (Sweden)

    Yang F

    2017-09-01

    Full Text Available Fei Yang,1,* Jun-Yi Gao,2,* Hua Chen,1 Zhen-Hua Du,1 Xue-Qun Zhang,3 Wei Gao4 1Department of Pathology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 2Department of Clinical Medicine, Weifang Medical College, Weifang, 3Graduate School, Taishan Medical University, Xintai, 4Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, People’s Republic of China *These authors contributed equally to this work Background: Colon cancer is the third most common cancer in the world, and its metastasis and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway plays a crucial role in the pathogenesis of colon cancer. The aim of this study was to investigate the targeting of PI3K in colon cancer cells HT-29 and HCT-116 in vitro. Methods: In HT-29 and HCT-116 cells, BEZ235, a dual inhibitor of PI3K/mTOR, and shRNAtarget to PI3KCA were used to inhibit PI3K/Akt/mTOR pathway. The inhibition efficiency of PI3K/Akt/mTOR pathway was detected by RT-PCR and Western blot. Cell proliferation, migration, invasion, and apoptosis were evaluated by Cell Counting Kit-8, Transwell, and flow cytometry assays. The expression of apoptosis-related proteins (cleavage caspase 3, Bcl-2, Bax, and Bim were also detected. Results: We found that in HT-29 and HCT-116 cells, the treatment of BEZ235 (1 µM and PI3KCA knockdown inhibited the activation of PI3K/Akt/mTOR pathway and significantly suppressed cell proliferation, migration, and invasion of HT-29 and HCT-116 cells. In addition, we confirmed that knockdown of BEZ235 and PI3KCA induced cell apoptosis through the upregulated levels of cleavage caspase 3 and Bax and downregulated expression of Bcl-2 and Bim. Conclusion: Our results indicated that targeted inhibition of the PI3K/Akt/mTOR pathway impaired cell proliferation, survival, and invasion in human colon cancer. Keywords: human colon cancer, PI3K/Akt/mTOR pathway, BEZ235, PI3KCA knockdown

  7. Epidemiology of worldwide spinal cord injury: a literature review

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    Kang Y

    2017-12-01

    Full Text Available Yi Kang,1,2,* Han Ding,1,2,* Hengxing Zhou,1,2 Zhijian Wei,1,2 Lu Liu,1,2 Dayu Pan,1,2 Shiqing Feng1,2 1Department of Orthopaedics, Tianjin Medical University General Hospital, 2Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, People’s Republic of China *These authors contributed equally to this work Study design: A literature review of worldwide epidemiology of spinal cord injury (SCI. Objectives: To review the epidemiological indicators of SCI, such as incidence, prevalence, demographic characteristics, etiology, level and severity of injury, complications and mortality. Setting: The Department of Orthopaedics, Tianjin Medical University General Hospital, ­Heping District, Tianjin, People’s Republic of China. Methods: We searched articles published in PubMed, Medline, EMBASE and the Web of ­Science between January 1993 and June 2017 using the key words “spinal cord injury”, “­traumatic spinal cord injury”, “non-traumatic spinal cord injury” and “epidemiology”. The incidence, etiology, prevalence, patient demographics, level and severity of injury, complications and mortality were reviewed from the articles. Results: The epidemiology of SCI has changed. Motor vehicle accidents and falls have become the most common reasons of injury gradually. Incidence of SCI varies by regions or countries, and it has gradually increased with the expansion of human activities. The number of male patients were significantly more than female, the average age of patients with SCI had a tendency to increase gradually. The cervical level of spine was the most common part of injury; there were more number of patients with tetraplegia than patients with paraplegia. Electrolyte disturbances, pulmonary infections, urinary tract infections and bedsores were the four most common complications. Conclusion: We must have a greater

  8. Original endoscopic orbital decompression of lateral wall through hairline approach for Graves’ ophthalmopathy: an innovation of balanced orbital decompression

    Directory of Open Access Journals (Sweden)

    Gong Y

    2018-03-01

    Full Text Available Yi Gong,1,* Jiayang Yin,2,* Boding Tong,2 Jingkun Li,3 Jiexi Zeng,2 Zhongkun Zuo,1 Fei Ye,1 Yongheng Luo,4 Jing Xiao,1 Wei Xiong2 1Department of Minimal Invasive Surgery, The Second Xiangya Hospital, Central South University, Changsha, China; 2Department of Ophthalmology and Eye Research Center, The Second Xiangya Hospital, Central South University, Changsha, China; 3E.N.T Department, The Second Xiangya Hospital, Central South University, Changsha, China; 4Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China *These authors contributed equally to this work Background: Orbital decompression is an important surgical procedure for treatment of Graves’ ophthalmopathy (GO, especially in women. It is reasonable for balanced orbital decompression of the lateral and medial wall. Various surgical approaches, including endoscopic transnasal surgery for medial wall and eye-side skin incision surgery for lateral wall, are being used nowadays, but many of them lack the validity, safety, or cosmetic effect. Patients and methods: Endoscopic orbital decompression of lateral wall through hairline approach and decompression of medial wall via endoscopic transnasal surgery was done to achieve a balanced orbital decompression, aiming to improve the appearance of proptosis and create conditions for possible strabismus and eyelid surgery afterward. From January 29, 2016 to February 14, 2017, this surgery was performed on 41 orbits in 38 patients with GO, all of which were at inactive stage of disease. Just before surgery and at least 3 months after surgery, Hertel’s ophthalmostatometer and computed tomography (CT were used to check proptosis and questionnaires of GO quality of life (QOL were completed. Findings: The postoperative retroversion of eyeball was 4.18±1.11 mm (Hertel’s ophthalmostatometer and 4.17±1.14 mm (CT method. The patients’ QOL was significantly improved, especially the change in appearance without

  9. Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells

    Directory of Open Access Journals (Sweden)

    Lee HC

    2013-06-01

    Full Text Available Hsin-chung Lee,1,2 Qing-Dong Ling,1,3 Wan-Chun Yu,4 Chunh-Ming Hung,4 Ta-Chun Kao,4 Yi-Wei Huang,4 Akon Higuchi3–51Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taoyuan, 2Department of Surgery, Cathay General Hospital, Da'an District, Taipei, 3Cathay Medical Research Institute, Cathay General Hospital, Hsi-Chi City, Taipei, 4Department of Chemical and Materials Engineering, National Central University, Jhongli, Taoyuan, Taiwan; 5Department of Reproduction, National Research Institute for Child Health and Development, Okura, Tokyo, JapanPurpose: We evaluated the higher levels of carcinoembryonic antigen (CEA secreted by the LoVo human colon carcinoma cells in a medium containing anticancer drugs. Drug-resistant LoVo cells were analyzed by subcutaneously xenotransplanting them into mice. The aim of this study was to evaluate whether the drug-resistant cells isolated in this study were cancer-initiating cells, known also as cancer stem cells (CSCs.Methods: The production of CEA was investigated in LoVo cells that were cultured with 0–10 mM of anticancer drugs, and we evaluated the increase in CEA production by the LoVo cells that were stimulated by anticancer drug treatment. The expression of several CSC markers in LoVo cells treated with anticancer drugs was also evaluated. Following anticancer drug treatment, LoVo cells were injected subcutaneously into the flanks of severe combined immunodeficiency mice in order to evaluate the CSC fraction.Results: Production of CEA by LoVo cells was stimulated by the addition of anticancer drugs. Drug-resistant LoVo cells expressed lower levels of CSC markers, and LoVo cells treated with any of the anticancer drugs tested did not generate tumors within 8 weeks from when the cells were injected subcutaneously into severe combined immunodeficiency mice. These results suggest that the drug-resistant LoVo cells have a smaller population of CSCs than the

  10. Dual tumor-targeted poly(lactic-co-glycolic acid–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

    Directory of Open Access Journals (Sweden)

    Chen J

    2017-08-01

    Full Text Available Jia Chen,1,2,* Qi Wu,1,* Li Luo,1 Yi Wang,1 Yuan Zhong,1 Han-Bin Dai,1 Da Sun,1,3 Mao-Ling Luo,4 Wei Wu,1 Gui-Xue Wang1 1Key Laboratory for Biorheological Science and Technology, Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University, Chongqing, 2Institute of Laboratory Animals, Sichuan Academy of Medical Science, Sichuan Provincial People’s Hospital, Chengdu, 3Institute of Life Sciences, Wenzhou University, Wenzhou, 4School of Medicine, Wuhan University, Wuhan, China *These authors contributed equally to this work Abstract: Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic-co-glycolic acid (PLGA–polyethylene glycol (PEG–folic acid (FA copolymer was able to self-assemble into nanoparticles with favorable hydrodynamic diameters of around 100 nm and negative surface charge in aqueous solution, which was expected to enhance intracellular antitumor drug delivery by advanced dual tumor-target effects, ie, enhanced permeability and retention induced the passive target, and FA mediated the positive target. Fluorescence-activated cell-sorting and confocal laser-scanning microscopy results confirmed that doxorubicin (model drug loaded into PLGA-PEG-FA nanoparticles was able to be delivered efficiently into tumor cells and accumulated at nuclei. In addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium, and zebrafish-development experiments demonstrated that PLGA-PEG-FA nanoparticles were biocompatible and secure for biomedical applications, even at high polymer concentration (0.1 mg/mL, both in vitro and in vivo. Therefore, PLGA-PEG-FA nanoparticles provide a feasible controlled-release platform for secure and efficient antitumor drug

  11. Induction of systemic and mucosal immunity against methicillin-resistant Staphylococcus aureus infection by a novel nanoemulsion adjuvant vaccine

    Directory of Open Access Journals (Sweden)

    Sun HW

    2015-12-01

    Full Text Available HongWu Sun,1,* Chao Wei,1,* BaoShuai Liu,1 HaiMing Jing,1 Qiang Feng,2 YaNan Tong,1 Yun Yang,1 LiuYang Yang,1 QianFei Zuo,1 Yi Zhang,1 QuanMing Zou,1 Hao Zeng1 1National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, 2Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, People’s Republic of China *These authors contributed equally to this work Abstract: The Gram-positive bacterial pathogen methicillin-resistant Staphylococcus aureus (MRSA can cause infections in the bloodstream, endocardial tissue, respiratory tract, culture-confirmed skin, or soft tissue. There are currently no effective vaccines, and none are expected to become available in the near future. An effective vaccine capable of eliciting both systemic and mucosal immune responses is also urgently needed. Here, we reported a novel oil-in-water nanoemulsion adjuvant vaccine containing an MRSA recombination protein antigen, Cremophor EL-35® as a surfactant, and propylene glycol as a co-surfactant. This nanoemulsion vaccine, whose average diameter was 31.34±0.49 nm, demonstrated good protein structure integrity, protein specificity, and good stability at room temperature for 1 year. The intramuscular systemic and nasal mucosal immune responses demonstrated that this nanoemulsion vaccine could improve the specific immune responses of immunoglobulin (IgG and related subclasses, such as IgG1, IgG2a, and IgG2b, as well as IgA, in the serum after Balb/c mice intramuscular immunization and C57 mice nasal immunization. Furthermore, this nanoemulsion vaccine also markedly enhanced the interferon-γ and interleukin-17A cytokine cell immune response, improved the survival ratio, and reduced bacterial colonization. Taken together, our results show that this novel nanoemulsion vaccine has great potential and is a

  12. Top five medical innovations in China mainland since Xinhai revolution [1911]: results of AME survey-002.

    Science.gov (United States)

    Wáng, Yì-Xiáng J; Xiao, Fan

    2015-06-01

    This survey aims to scrutinize important medical innovations in Chinese mainland since Xinhai (Hsin-hai) revolution in 1911, which marked the end of Manchurian imperial rule and the beginning of China's republican era. An online cross-sectional survey was carried out during the period of Dec 29, 2014 to Feb 5, 2015, totaling 37 days. The survey was conducted on the platform provided by DXY (www.dxy.cn), which is the largest medical and paramedical related website in China. An email was sent to all DXY registered users to invite them to participate in a 5-minute survey. The participants were asked to nominate up to four important medical innovations in China mainland since Xinhai revolution. The participant could select 'zero' which means he/she felt there was no important medical innovations, or he/she did not know important medical innovations. It was noted that important medical innovations refer to (I) those with practical and almost immediate significance to improve healthcare; (II) should not only be introducing western technique to China, but those involve major improvement of existing western techniques count; (III) should not be those with important theoretical discovery but did not have almost immediate significance to improve healthcare. In total 1,513 DXY users participated in the voting. Totally 489 (32.3%), 441 (29.1%), 342 (22.6%), 150 (9.9%), 91 (6.0%) participants provided 0, 1, 2, 3, 4 nominations respectively. (I) Artemisine (Qinghaosu) for malaria treatment (Project 523 team, 1972); (II) arsenic Trioxide (As2O3) for acute promyelocytic leukemia (APL) treatment (ZHANG Ting-Dong and colleagues, 1970s); (III) limb re-plantation (CHEN Zhong-Wei and colleagues, 1963); (IV) all-trans retinoic acid (ATRA) for APL treatment (WANG Zhen-Yi and colleagues, 1988); and (V) Wu's mask for plague prevention (WU Lien-The, 1910), were voted as the top five innovations in China mainland since Xinhai revolution, with 375, 96, 91, 53, and 8 votes respectively. In

  13. The clinical pathological characteristics and prognosis of FGFR1 gene amplification in non-small-cell lung cancer: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Xie FJ

    2016-01-01

    Full Text Available Fa-Jun Xie,1,2 Hong-Yang Lu,1,3 Qiu-Qing Zheng,3 Jing Qin,1,3 Yun Gao,3 Yi-Ping Zhang,1,3 Xun Hu,2 Wei-Min Mao3,4 1Department of Medical Oncology, Zhejiang Cancer Hospital, 2Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences, Second Affiliated Hospital, Zhejiang University School of Medicine,3Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus, Hangzhou, 4Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China Abstract: FGFR1 amplification is recognized as a novel therapy target for non-small-cell lung cancer (NSCLC, especially in squamous cell carcinoma (SCC. However, the association between FGFR1 amplification and the clinicopathological characteristics of NSCLC remains controversial. We performed a meta-analysis of 17 eligible studies to examine the correlation between FGFR1 gene amplification and clinicopathological characteristics. FGFR1 amplification was closely related to these clinicopathological features, including sex (odds ratio [OR] 2.05, 95% confidence interval [CI] 1.50–2.80, smoking (OR 3.31, 95% CI 2.02–5.44, and histology (OR 3.60, 95% CI 2.82–4.59. FGFR1 amplification was associated with shorter overall survival, and no significant heterogeneity existed between studies (I2=3.8%. We should note that publication bias may partly account for these results, but our findings remained significant after the trim-and-fill method (hazard ratio 1.22, 95% CI 1.06–1.40. However, no significant correlation was found with poor disease-free survival (hazard ratio 1.43, 95% CI 0.96–2.12. In conclusion, this study showed that FGFR1 amplification was significantly associated with sex, smoking, and histology. FGFR1 amplification could be a marker of poor prognosis in NSCLC patients, especially in SCC patients

  14. Power, identity and antiquarian approaches in modern Chinese art’

    Directory of Open Access Journals (Sweden)

    Chia-Ling Yang

    2014-06-01

    Full Text Available The pursuit of antiquity was important for scholarly artists in constructing their knowledge of history and cultural identity in late Imperial China. Following various publications by Bi Yuan 畢沅 (1730-1797, Wu Yi 武億 (1745-1799 and Qian Daxin 錢大昕 (1728-1804 in the 18th century, the study and collecting of rubbings of Northern Wei stone inscriptions and steles was popular. Such spread of interest in jinshi, inscriptions on metal and stone, also formed a base for studying seal carving, epigraphy and archaic painting. While traditional antiquarians would cherish inscriptions which enabled them to correct mistakes in the transmitted historical texts and the Classics, however, much of the antiquarian activity was adapted to mere literary exercise or connoisseurship, for instance, to supplying materials which could provide models for seal-carving and calligraphy. Examples could be seen in the calligraphy works and seal carvings of the Xiling bajia 西泠八家 (Eight Masters of Xiling, i.e. Hangzhou, also known as Zhe School of Calligraphy and Carving. Their keen interest in seeking inspiration from steles for their artistic presentations has been recorded in their writing and painting. In addition, the way the scholar-collector of the 19th and early 20th centuries mounted the rubbings, seals, inscriptions, paintings, letters and textual evidence studies into one album shows a changing ideology: rubbings were not only for scholarly study in classical learning, but were regarded as part of the art form and were appreciated on various social occasions. The antiquarian movement ultimately served as a tool for re-writing art historiography in modern China. This paper aims to address the phenomenon and formation of the jinshi painting that dominated in late Imperial and early modern China. Through case studies of three important jinshi societies in Shanghai, I will investigate in what way literary taste from the southern region gradually

  15. The efficacy of herbal therapy on quality of life in patients with breast cancer: self-control clinical trial

    Directory of Open Access Journals (Sweden)

    Lai Yi Eliza Wong

    2010-07-01

    Full Text Available Lai Yi Eliza Wong1, Chun Kwok Wong2, Ping Chung Leung3, Wei Kei Christopher Lam41Assistant Professor, Department of Community and Family Medicine, The Chinese University of Hong Kong; 2Associate Professor, Department of Chemical Pathology, The Chinese University of Hong Kong; 3Director, Institute of Chinese Medicine, The Chinese University of Hong Kong, 5/F, School of Public Health Building, Prince of Wales Hospital, NT, Hong Kong; 4Chairman, Department of Chemical Pathology, The Chinese University of Hong Kong, 1/F, Clinical Sciences Building, Prince of Wales Hospital, NT, Hong KongBackground: Mounting evidence indicates that herbal therapy is effective in alleviating anxiety, lessening cancer treatment-related side-effects, and facilitating rehabilitation. This is the first trial to examine the herbal therapy of combined yunzhi and danshen on quality of life among breast cancer patients.Methods: A multicenter, longitudinal, and self-control study was used. Eighty-two breast cancer patients were given combined yunzhi and danshen capsules for six months on a daily basis. Data collection including quality of life, vitality status and adverse effects were taken.Results: Results showed a significant improvement in physical function, role-physical, role-emotion and health transition (P < 0.05. Patients also reported less fatigue, better quality of sleep, better appetite, more regular bowel movements and more stable emotions (P < 0.05. As far as side-effects were concerned, only mild discomforts including sore throat (13.4% and dry mouth (9.8% were recorded.Conclusion: The findings add clinical evidence to support the beneficial effects of herbal therapy on quality of life and vitality status in breast cancer patients. Therefore, herbal therapy has a potentially important role to play in managing psychological distress in cancer patients. This study also suggests that herbal therapy is clinically acceptable and can be used safely with breast cancer

  16. The γ-gliadin-like γ-prolamin genes in the tribe Triticeae

    Indian Academy of Sciences (India)

    Supplementary data: The γ-gliadin-like γ-prolamin genes in the tribe Triticeae. Peng-Fei Qi, Cheng-Xing Le, Zhao Wang, Yu-Bin Liu, Qing Chen, Zhen-Zhen Wei, Bin-Jie Xu, Zheng-Yuan Wei,. Shou-Fen Dai, Yu-Ming Wei and You-Liang Zheng. J. Genet. 93, 35–41. Table 1. The γ-prolamin genes of diploid Triticeae species.

  17. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

    Science.gov (United States)

    Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P; Esko, Tõnu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L; Alfred, Tamuno; Feitosa, Mary F; Masca, Nicholas G D; Manning, Alisa K; Medina-Gomez, Carolina; Mudgal, Poorva; Ng, Maggie C Y; Reiner, Alex P; Vedantam, Sailaja; Willems, Sara M; Winkler, Thomas W; Abecasis, Gonçalo; Aben, Katja K; Alam, Dewan S; Alharthi, Sameer E; Allison, Matthew; Amouyel, Philippe; Asselbergs, Folkert W; Auer, Paul L; Balkau, Beverley; Bang, Lia E; Barroso, Inês; Bastarache, Lisa; Benn, Marianne; Bergmann, Sven; Bielak, Lawrence F; Blüher, Matthias; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; Böger, Carsten A; Bork-Jensen, Jette; Bots, Michiel L; Bottinger, Erwin P; Bowden, Donald W; Brandslund, Ivan; Breen, Gerome; Brilliant, Murray H; Broer, Linda; Brumat, Marco; Burt, Amber A; Butterworth, Adam S; Campbell, Peter T; Cappellani, Stefania; Carey, David J; Catamo, Eulalia; Caulfield, Mark J; Chambers, John C; Chasman, Daniel I; Chen, Yii-Der I; Chowdhury, Rajiv; Christensen, Cramer; Chu, Audrey Y; Cocca, Massimiliano; Collins, Francis S; Cook, James P; Corley, Janie; Corominas Galbany, Jordi; Cox, Amanda J; Crosslin, David S; Cuellar-Partida, Gabriel; D'Eustacchio, Angela; Danesh, John; Davies, Gail; Bakker, Paul I W; Groot, Mark C H; Mutsert, Renée; Deary, Ian J; Dedoussis, George; Demerath, Ellen W; Heijer, Martin; Hollander, Anneke I; Ruijter, Hester M; Dennis, Joe G; Denny, Josh C; Di Angelantonio, Emanuele; Drenos, Fotios; Du, Mengmeng; Dubé, Marie-Pierre; Dunning, Alison M; Easton, Douglas F; Edwards, Todd L; Ellinghaus, David; Ellinor, Patrick T; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-Eleni; Farooqi, I Sadaf; Faul, Jessica D; Fauser, Sascha; Feng, Shuang; Ferrannini, Ele; Ferrieres, Jean; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franco, Oscar H; Franke, Andre; Franks, Paul W; Friedrich, Nele; Frikke-Schmidt, Ruth; Galesloot, Tessel E; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Gibson, Jane; Giedraitis, Vilmantas; Gjesing, Anette P; Gordon-Larsen, Penny; Gorski, Mathias; Grabe, Hans-Jörgen; Grant, Struan F A; Grarup, Niels; Griffiths, Helen L; Grove, Megan L; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeff; Hakonarson, Hakon; Hammerschlag, Anke R; Hansen, Torben; Harris, Kathleen Mullan; Harris, Tamara B; Hattersley, Andrew T; Have, Christian T; Hayward, Caroline; He, Liang; Heard-Costa, Nancy L; Heath, Andrew C; Heid, Iris M; Helgeland, Øyvind; Hernesniemi, Jussi; Hewitt, Alex W; Holmen, Oddgeir L; Hovingh, G Kees; Howson, Joanna M M; Hu, Yao; Huang, Paul L; Huffman, Jennifer E; Ikram, M Arfan; Ingelsson, Erik; Jackson, Anne U; Jansson, Jan-Håkan; Jarvik, Gail P; Jensen, Gorm B; Jia, Yucheng; Johansson, Stefan; Jørgensen, Marit E; Jørgensen, Torben; Jukema, J Wouter; Kahali, Bratati; Kahn, René S; Kähönen, Mika; Kamstrup, Pia R; Kanoni, Stavroula; Kaprio, Jaakko; Karaleftheri, Maria; Kardia, Sharon L R; Karpe, Fredrik; Kathiresan, Sekar; Kee, Frank; Kiemeney, Lambertus A; Kim, Eric; Kitajima, Hidetoshi; Komulainen, Pirjo; Kooner, Jaspal S; Kooperberg, Charles; Korhonen, Tellervo; Kovacs, Peter; Kuivaniemi, Helena; Kutalik, Zoltán; Kuulasmaa, Kari; Kuusisto, Johanna; Laakso, Markku; Lakka, Timo A; Lamparter, David; Lange, Ethan M; Lange, Leslie A; Langenberg, Claudia; Larson, Eric B; Lee, Nanette R; Lehtimäki, Terho; Lewis, Cora E; Li, Huaixing; Li, Jin; Li-Gao, Ruifang; Lin, Honghuang; Lin, Keng-Hung; Lin, Li-An; Lin, Xu; Lind, Lars; Lindström, Jaana; Linneberg, Allan; Liu, Ching-Ti; Liu, Dajiang J; Liu, Yongmei; Lo, Ken S; Lophatananon, Artitaya; Lotery, Andrew J; Loukola, Anu; Luan, Jian'an; Lubitz, Steven A; Lyytikäinen, Leo-Pekka; Männistö, Satu; Marenne, Gaëlle; Mazul, Angela L; McCarthy, Mark I; McKean-Cowdin, Roberta; Medland, Sarah E; Meidtner, Karina; Milani, Lili; Mistry, Vanisha; Mitchell, Paul; Mohlke, Karen L; Moilanen, Leena; Moitry, Marie; Montgomery, Grant W; Mook-Kanamori, Dennis O; Moore, Carmel; Mori, Trevor A; Morris, Andrew D; Morris, Andrew P; Müller-Nurasyid, Martina; Munroe, Patricia B; Nalls, Mike A; Narisu, Narisu; Nelson, Christopher P; Neville, Matt; Nielsen, Sune F; Nikus, Kjell; Njølstad, Pål R; Nordestgaard, Børge G; Nyholt, Dale R; O'Connel, Jeffrey R; O'Donoghue, Michelle L; Olde Loohuis, Loes M; Ophoff, Roel A; Owen, Katharine R; Packard, Chris J; Padmanabhan, Sandosh; Palmer, Colin N A; Palmer, Nicholette D; Pasterkamp, Gerard; Patel, Aniruddh P; Pattie, Alison; Pedersen, Oluf; Peissig, Peggy L; Peloso, Gina M; Pennell, Craig E; Perola, Markus; Perry, James A; Perry, John R B; Pers, Tune H; Person, Thomas N; Peters, Annette; Petersen, Eva R B; Peyser, Patricia A; Pirie, Ailith; Polasek, Ozren; Polderman, Tinca J; Puolijoki, Hannu; Raitakari, Olli T; Rasheed, Asif; Rauramaa, Rainer; Reilly, Dermot F; Renström, Frida; Rheinberger, Myriam; Ridker, Paul M; Rioux, John D; Rivas, Manuel A; Roberts, David J; Robertson, Neil R; Robino, Antonietta; Rolandsson, Olov; Rudan, Igor; Ruth, Katherine S; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Sapkota, Yadav; Sattar, Naveed; Schoen, Robert E; Schreiner, Pamela J; Schulze, Matthias B; Scott, Robert A; Segura-Lepe, Marcelo P; Shah, Svati H; Sheu, Wayne H-H; Sim, Xueling; Slater, Andrew J; Small, Kerrin S; Smith, Albert V; Southam, Lorraine; Spector, Timothy D; Speliotes, Elizabeth K; Starr, John M; Stefansson, Kari; Steinthorsdottir, Valgerdur; Stirrups, Kathleen E; Strauch, Konstantin; Stringham, Heather M; Stumvoll, Michael; Sun, Liang; Surendran, Praveen; Swift, Amy J; Tada, Hayato; Tansey, Katherine E; Tardif, Jean-Claude; Taylor, Kent D; Teumer, Alexander; Thompson, Deborah J; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Thuesen, Betina H; Tönjes, Anke; Tromp, Gerard; Trompet, Stella; Tsafantakis, Emmanouil; Tuomilehto, Jaakko; Tybjaerg-Hansen, Anne; Tyrer, Jonathan P; Uher, Rudolf; Uitterlinden, André G; Uusitupa, Matti; Laan, Sander W; Duijn, Cornelia M; Leeuwen, Nienke; van Setten, Jessica; Vanhala, Mauno; Varbo, Anette; Varga, Tibor V; Varma, Rohit; Velez Edwards, Digna R; Vermeulen, Sita H; Veronesi, Giovanni; Vestergaard, Henrik; Vitart, Veronique; Vogt, Thomas F; Völker, Uwe; Vuckovic, Dragana; Wagenknecht, Lynne E; Walker, Mark; Wallentin, Lars; Wang, Feijie; Wang, Carol A; Wang, Shuai; Wang, Yiqin; Ware, Erin B; Wareham, Nicholas J; Warren, Helen R; Waterworth, Dawn M; Wessel, Jennifer; White, Harvey D; Willer, Cristen J; Wilson, James G; Witte, Daniel R; Wood, Andrew R; Wu, Ying; Yaghootkar, Hanieh; Yao, Jie; Yao, Pang; Yerges-Armstrong, Laura M; Young, Robin; Zeggini, Eleftheria; Zhan, Xiaowei; Zhang, Weihua; Zhao, Jing Hua; Zhao, Wei; Zhao, Wei; Zhou, Wei; Zondervan, Krina T; Rotter, Jerome I; Pospisilik, John A; Rivadeneira, Fernando; Borecki, Ingrid B; Deloukas, Panos; Frayling, Timothy M; Lettre, Guillaume; North, Kari E; Lindgren, Cecilia M; Hirschhorn, Joel N; Loos, Ruth J F

    2018-05-01

    In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

  18. subjective approach to subjective approach to human physiological

    African Journals Online (AJOL)

    eobe

    the only physiological variables that influence the heat balance [4]. Yao et al [2] .... between the human responses and outdoor climate. 4.1 Subjective Response ... months seem to be influenced by cloud cover rather than the altitude.

  19. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 100 of 163 ... H Rüther, C Held, R Bhurtha, R Schroeder, S Wessels ... Richard Fiifi Annan, Yao Yevenyo Ziggah, John Ayer, Christian Amans Odutola ... Simon Hull, Tshepiso Sehume, Sibonakaliso Sibiya, Lusanda Sothafile, Jennifer ...

  20. Microwave photonics shines

    Science.gov (United States)

    Won, Rachel

    2011-12-01

    The combination of microwave photonics and optics has advanced many applications in defence, wireless communications, imaging and network infrastructure. Rachel Won talks to Jianping Yao from the University of Ottawa in Canada about the importance of this growing field.

  1. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Xiaoming Liao1 Hongyang Zhu1 Guangfu Yin1 Zhongbing Huang1 Yadong Yao1 Xianchun Chen1. College of Materials Science and Engineering, Sichuan University, Chengdu 610064, P.R. of China ...

  2. Genetic diversity in three morphological types of Astragalus ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-09-15

    Sep 15, 2009 ... high genetic diversity suggested that each type had a potential to develop new strains or cultivars and .... herbs and widespread distributed species (Yao et al.,. 2008) ... 1) A. membranaceus var. mongholicus is a cross-.

  3. QING YING LIU

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. QING YING LIU. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1329-1333. Synthesis and enhanced photocatalytic activity of g-C 3 N 4 hybridized CdS nanoparticles · QING YING LIU YI LING QI YI FAN ZHENG XU CHUN SONG.

  4. North Korean Civil-Military Trends: Military-First Politics to a Point

    Science.gov (United States)

    2006-09-01

    to the Great Leader. Yi Yong Mu. The NDC’s impact on the formal leadership lineup was made clear by 2001, when Yi Yong Mu, vice chairman of the NDC...to be restricted, as are career bonds that could come about between officers through sequential appointments to same commands. • First time

  5. China's 'recycling economy'

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2009-01-01

    Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin.......Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin....

  6. Components of non-anthocyanin phenolic compounds in wines of ...

    African Journals Online (AJOL)

    Zuo Shan Yi, Zuo Shan Er, Shuang Hong, Shuang You and Shuang Feng) of Vitis amurensis and two hybrid cultivars (Zuo Hong Yi and Zuo You Hong) were examined by high-performance liquid chromatography/electrospray ionization tandem ...

  7. Trilingual Education in China: Perspectives from a University Programme for Minority Students

    Science.gov (United States)

    Liu, Jie; Edwards, Viv

    2017-01-01

    Attention to trilingual education programmes in China has tended to focus on basic education; there had been little attention to date on the higher education sector. This paper will attempt to bridge this gap by exploring a Yi-English-Chinese trilingual education programme through case studies of three Yi students, using the "River of…

  8. Tropical Journal of Pharmaceutical Research - Vol 15, No 3 (2016)

    African Journals Online (AJOL)

    Wan Wu, Wei Chen, Qiong Jin, 447-451 ... Chung-Shih Chen, Mei-Lin Wang, Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chien-Fu Huang, ... Yan-Qiong Li, Rui Hu, Li-Hui Zhong, Qian Sun, You-Ping Yan, 527-533.

  9. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Three duplication events and variable molecular evolution characteristics involved in multiple GGPS genes of six Solanaceae species. FENG LI CHUNYANG WEI CHAN QIAO ZHENXI CHEN PENG WANG PAN WEI RAN WANG LIFENG JIN JUN YANG FUCHENG LIN ZHAOPENG LUO. RESEARCH NOTE Volume 95 Issue ...

  10. Human epidermal growth factor receptor (HER 2)/neu expression ...

    African Journals Online (AJOL)

    use

    2011-11-23

    Nov 23, 2011 ... expression and gene amplification in colorectal cancer. Wei Deng 1, Wei-Guo .... patients whose clinical data (include diagnosis, age, sex, address, disease history, etc) intact ..... Anal Cell Pathol.10: 149-160. Tapia C, Glatz K, ...

  11. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ZHOUCHAO WEI1 2 KARTHIKEYAN RAJAGOPAL3 WEI ZHANG4 SIFEU TAKOUGANG KINGNI5 AKIF AKGÜL6. School of Mathematics and Physics, China University of Geosciences, Wuhan 430074, China; Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing, Yulin ...

  12. On ideals and quotients of AT AT AT-algebras

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 118; Issue 4. On Ideals and Quotients of A T -Algebras. Changguo Wei. Volume 118 Issue 4 November 2008 pp ... Author Affiliations. Changguo Wei1. School of Mathematical Sciences, Ocean University of China, Qingdao 266071, People's Republic of China ...

  13. Verification of the utility of molecular markers linked to the multiple ...

    African Journals Online (AJOL)

    GREGORY

    2010-08-30

    Aug 30, 2010 ... Feng Hui*, Wang Lili, Wei Peng, Liu Zhiyong, Li Chengyu, Wang Yugang, Ji Ruiqin and Zhang. Huaqing ..... Chin. Agric. Sci. Bull. 22: 377-379. Li CY, Feng H, Wei P, Wang LL, Zhang J, Yang HN, Jiang N (2009). Directional transfer of the genic multiple allele inherited male sterile line in Chinese cabbage.

  14. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Yan-Qin Xu Guo-Yan Wei Yin Zhou Fei Ge Guang-Ming Luo · More Details Fulltext PDF. pp e25-e28. Abundance and characteristics of microsatellite markers in Gansu zokor (Eospalax cansus), a fossorial rodent endemic to the Loess plateau, China · Junhu Su Limin Hua Jing Wang Dianne M. Gleeson Yanming Wei Robyn ...

  15. Conduct Disorders: Are Boot Camps Effective?

    Science.gov (United States)

    Jeter, LaVaughn V.

    2010-01-01

    Youth diagnosed with "conduct disorder" are often placed in programs using forced compliance and coercive control. One type of intervention used to treat conduct disorder is the boot camp. The basic idea is that disruptive behaviors can be corrected by strict behavioral regulation and an emphasis on skills training (Weis & Toolis 2009; Weis,…

  16. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. WEI XIONG. Articles written in Sadhana. Volume 41 Issue 6 June 2016 pp 621-632. Nonstationary weak signal detection based on normalization stochastic resonance with varying parameters · HAIBIN ZHANG WEI XIONG SHANGBIN ZHANG QINGBO HE FANRANG KONG · More Details Abstract ...

  17. African Journal of Biotechnology - Vol 11, No 16 (2012)

    African Journals Online (AJOL)

    Subcellular localization of cadmium in hyperaccumulator Populus × canescens · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. HP Dai, C Shan, Y Wei, JG Liang, TX Yang, WQ Sa, AZ Wei, 3779-3787 ...

  18. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Schinzel–Giedion syndrome: a novel case, review and revised diagnostic criteria · WEI-LIANG LIU ZHI-XU HE FANG LI RONG AI HONG-WEI MA · More Details Abstract Fulltext PDF. Schinzel–Giedion syndrome (SGS) is a rare autosomal dominant inheritance disorder. Heterozygous de novo mutations in the SETBP1 gene ...

  19. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. Ju Wei. Articles written in Journal of Earth System Science. Volume 125 Issue 5 July 2016 pp 1021-1031. Tectonic stress accumulation in Bohai–Zhangjiakou Seismotectonic Zone based on 3D visco-elastic modelling · Ju Wei Sun Weifeng Ma Xiaojing Jiang Hui.

  20. Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats

    Directory of Open Access Journals (Sweden)

    Li ZR

    2012-03-01

    Full Text Available Zhanrong Li1, Lin Yao1, Jingguo Li2, Wenxin Zhang1, Xianghua Wu1, Yi Liu1, Miaoli Lin1, Wenru Su1, Yongping Li1, Dan Liang11State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 2School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, People's Republic of ChinaPurpose: Celastrol, a traditional Chinese medicine, is widely used in anti-inflammation and anti-angiogenesis research. However, the poor water solubility of celastrol restricts its further application. This paper aims to study the effect of celastrol nanoparticles (CNPs on corneal neovascularization (CNV and determine the possible mechanism.Methods: To improve the hydrophilicity of celastrol, celastrol-loaded poly(ethylene glycol-block-poly(ε-caprolactone nanopolymeric micelles were developed. The characterization of CNPs was measured by dynamic light scattering and transmission electron microscopy analysis. Celastrol loading content and release were assessed by ultraviolet-visible analysis and high performance liquid chromatography, respectively. In vitro, human umbilical vein endothelial cell proliferation and capillary-like tube formation were assayed. In vivo, suture-induced CNV was chosen to evaluate the effect of CNPs on CNV in rats. Immunohistochemistry for CD68 assessed the macrophage infiltration of the cornea on day 6 after surgery. Real-time quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay were used to evaluate the messenger ribonucleic acid and protein levels, respectively, of vascular endothelial growth factor, matrix metalloproteinase 9, and monocyte chemoattractant protein 1 in the cornea.Results: The mean diameter of CNPs with spherical shape was 48 nm. The celastrol loading content was 7.36%. The release behavior of CNPs in buffered solution (pH 7.4 showed a typical two-phase release profile. CNPs inhibited the proliferation of human umbilical vein endothelial

  1. Leerstellen, weiße Flecken und blassrote Zeichen im Schnee. Von Sinnverlust und Sinnfindung im mythischen Land der Kham-Nomaden in Christoph Ransmayrs Roman «Der fliegende Berg»[Blank Spots, White Flecks and Pale Red Signs in the Snow. Of Meaning Lost and Found in the Mythical Land of the Kham Nomads in Christoph Ransmayr’s Novel «The Flying Mountain»

    Directory of Open Access Journals (Sweden)

    Gabriele Eichmanns Maier

    2017-06-01

    Full Text Available In his novel Der fliegende Berg, Christoph Ransmayr plays with seemingly contradictory myths that surround the Himalayan mountain Phur-Ri, a mountain that is not marked on any maps and symbolizes a void, a figment of the imagination that serves as a foil for unfulfilled longings and desires. Using Roland Barthes and Mircea Eliade as its theoretical framework, this article analyzes the function of myths in Ransmayr’s novel and explores whether his use of myth can fill the void with meaning – or whether the void remains a vacuum that repells rather than allows for any form of signification.

  2. Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors

    Directory of Open Access Journals (Sweden)

    Guo W

    2017-03-01

    Full Text Available Wei Guo,1,2,* Yabing Zheng,2,* Bing Xu,1 Fang Ma,1 Chang Li,3 Xiaoqian Zhang,4 Yao Wang,1 Xiaotian Chang1 1Medical Research Center, Shandong Provincial Qianfoshan Hospital, 2Obstetrical Department, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, 3Pathology Department, Tengzhou Central People’s Hospital, Tengzhou, 4Clinical Laboratory, PKU Care Luzhong Hospital, Zibo, Shandong, People’s Republic of China *These authors contributed equally to this work Background: Peptidylarginine deiminase (PAD catalyzes the conversion of arginine residues to citrulline residues, termed citrullination. Recent studies have suggested that PAD isoform 2 (PADI2 plays an important role in tumors, although its tumorigenic effect and mechanism are largely unknown. Materials and methods: Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA were used to investigate the expression level of PADI2 in various tumor tissues and patient blood samples, respectively. MNK-45 and Bel-7402 tumor cell lines originating from gastric and liver tumors, respectively, were treated with anti-PADI2 siRNA, and the subsequent cell proliferation, apoptosis and migration were observed. Polymerase chain reaction (PCR arrays, including Cancer PathwayFinder, Oncogenes and Tumor Suppressor Genes, p53 Signaling Pathway, Signal Transduction Pathway and Tumor Metastasis PCR arrays, were used to investigate the tumorigenic pathway of PADI2 in the siRNA-treated tumor cells. This analysis was verified by real-time PCR. Results: Immunohistochemistry detected significantly increased expression of PADI2 in invasive breast ductal carcinoma, cervical squamous cell carcinoma, colon adenocarcinoma, liver hepatocellular carcinoma, lung cancer, ovarian serous papillary adenocarcinoma and papillary thyroid carcinoma samples. ELISA detected a twofold increase in PADI2 expression in the blood of 48.3% of patients with liver cancer, 38% of patients with cervical

  3. Enhancement of osseointegration of polyethylene terephthalate artificial ligament by coating of silk fibroin and depositing of hydroxyapatite

    Directory of Open Access Journals (Sweden)

    Jiang J

    2014-09-01

    Full Text Available Jia Jiang,1,2 Fang Wan,1 Jianjun Yang,1 Wei Hao,3 Yaxian Wang,3 Jinrong Yao,3 Zhengzhong Shao,3 Peng Zhang,1 Jun Chen,1 Liang Zhou,4 Shiyi Chen11Fudan University Sports Medicine Center and Department of Sports Medicine and Arthroscopy Surgery, Huashan Hospital, 2State Key Laboratory of Molecular Engineering of Polymers, 3Laboratory of Advanced Materials, National Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, People’s Republic of China; 4Department of Forest Products, Anhui Agricultural University, Hefei Anhui Province, People’s Republic of ChinaBackground: Application of artificial ligament in anterior cruciate ligament reconstruction is one of the research focuses of sports medicine but the biological tendon–bone healing still remains a problem. The preliminary study of hydroxyapatite (HAP coating on the polyethylene terephthalate (PET surface could effectively induce the osteoblast differentiation, but the tendon–bone healing was still not stable. As a green synthesis process, the biomimetic mineralization can simulate the natural bone growth in vitro and in vivo.Methods: HAP crystals were grown under the guide of silk fibroin (SF PET surface by biomimetic route. Several techniques including scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy were utilized for proving the introduction of both SF and HAP. The viability and osseointegration of bone marrow stromal cells on the surface of three kinds of ligament, including PET group (non-coating group, PET+SF group (SF-coating group, and PET+SF+HAP group (combined HAP- and SF-coating group, were analyzed by CCK-8 assays and alkaline phosphatase (ALP detection. Seventy-two mature male New Zealand rabbits were randomly divided into three groups. Among them, 36 rabbits were sacrificed for mechanical testing, and

  4. Divan Şiirinde Mitolojik ve Efsanevî Şahısların Kullanımına İyi Bir Örnek: Nev’izâde Atâyî Divanı A Good Example To The Use Of Mythological And Legendary Figures In Divan Poetry: Divan Of Nev'izâde Atâyî

    Directory of Open Access Journals (Sweden)

    Mehmet Halil ERZEN

    2013-07-01

    Full Text Available "Mythology" in terms of the place in classical Turkish poetry, itsshape of handling and the contribution to the world of the poet'simagination draws attention as an important source that feeds thispoetry tradition. The poets of Divan have especially been influenced byPersian mythology; they have benefited from the opportunities that theold narratives offered while trying to catch the original expressions.Divan of Nev'izâde Atâyî that we have handled in this study has been agood example to to be the source for the divan poetry of mythology. Agreat number of mythological and legendary figures that we cameacross their use in the work, the imagination that the poet has wovenaround these names and his skill in handling these elements, oldnarrative in the tradition of classical Turkish poetry and richness ofmeaning created by individuals provide us significant informations. Theheroes with the source of Sehnâme referred in many couplets or thefigures whose origins are Arab and Greek have offered newopportunities for the poet in terms of strengthening the neededimagination and the possibility of expression. The semantic implicationsthat the people who took place in the work and the motives carried tothe poetry also have revealed the cultural richness of classical Turkishpoetry. In this case, the examination of Divan of Nev'izâde Atâyî interms of the handling of the mythological - legendary - historicalpersonalities will provide an opportunity to illustrate an importantaspect of the Klassical Turkish poetry. Because this work is seen tocontain quite rich material to exemplify the uses of intertextualparticularly on behalf of individuals. In the line with the poetization ofnew and original dreams, how Atâyî evaluated these figures and alsowith what aspects he interpreted is just possible with sorting andanalysis of this material. Klasik Türk şiirindeki yeri, ele alınış şekli ve şairin hayal dünyasına katkısı bakımından “mitoloji” bu şiir geleneğini besleyen önemli bir kaynak olarak dikkat çeker. Divan şairleri bilhassa Fars mitolojisinden etkilenmiş; orijinal ifadeler yakalamaya çalışırken eski anlatıların sunduğu olanaklardan yararlanmışlardır. Bu çalışmada ele aldığımız Nev’izâde Atâyî Divanı, mitolojinin divan şiirine kaynaklık etmesine iyi bir misal oluşturur. Eserde kullanımına rastladığımız mitolojik ve efsanevi şahsiyetlerin sayıca çokluğu, şairin bu isimler etrafında ördüğü imgelem ve söz konusu unsurları işlemedeki becerisi, Klasik Türk şiir geleneğinde eski anlatı ve şahısların yarattığı mânâ zenginliği konusunda bize dikkate değer bilgiler vermektedir. Birçok beyitte gönderme yapılan Şehnâme kaynaklı kahramanlar ya da Arap ve Yunan kökenli şahsiyetler, ihtiyaç duyulan hayal gücünü pekiştirmekte ve ifade imkânı bakımından şaire yeni olanaklar sunmaktadır. Eserde yer verilen kişi ve motiflerin şiire taşıdığı anlamsal açılımlar, Klasik Türk şiirinin kültürel zenginliğini de ayrıca ortaya koymaktadır. Bu durumda Nev’izâde Atâyî Divanı'nın mitolojik - efsanevi - tarihi kişiliklerin ele alınışı bakımından incelenmesi, Klasik Türk şiirini mühim bir yönüyle gözler önüne sermek fırsatı sağlayacaktır. Çünkü bu eserin, bilhassa şahıslar üzerinden metinler arası kullanımları örneklendirmek adına oldukça zengin malzemeyi ihtiva ettiği görülmektedir. Yeni ve orijinal hayallerin şiirleştirilmesi doğrultusunda Atâyî'nin söz konusu şahsiyetleri nasıl değerlendirdiği ve hangi yönleriyle yorumladığı da ancak bu malzemenin tasnif ve tahliliyle mümkündür.

  5. Calculating the variance and prediction intervals for estimates obtained from allometric relationships

    CSIR Research Space (South Africa)

    Nickless, A

    2010-09-01

    Full Text Available that across the range of x values, the variability in the error does not change (i.e. no heteroscedasticity). Often the power function in allometry is used: y = axbε This can be converted to: ln(yi) = β0 + β1 ln(xi) + εi The above assumptions now apply... to the regression relationship with the logged variables. Therefore ln(yi) is assumed to be normally distributed with mean µ=β0+β1 ln(xi) and variance σ2*. From regression theory it is known that the expected value (e) and variance (Var) of ln(yi) is given by...

  6. An Integrated Command and Control Architecture Concept for Unmanned Systems in the Year 2030

    Science.gov (United States)

    2010-06-01

    Tan Yean Wee ME5 Tong Kee Leong  Lu  Chin  Leong Chia Boon  Chye Henry Seet ME5 Lo Chee Hun ME5 Gabriel Tham Ho Liang Yoong Raymond Quah Quek Chee Luan Ang...Chia Tan Wei Chieh Chia Boon Chye Yionon Costica Lim Wei Han Eugene Ng Wei Gee Delvin...Gho Lo Chee Hun Tan Chin Wah John Ang Kha Luna Lu Chin Leong Tong Kee Leong

  7. Cloning and characterization of the densoviruses susceptible gene ...

    African Journals Online (AJOL)

    USER

    2010-06-21

    Jun 21, 2010 ... was located on genetic linkage 15 (Qin and Yi, 1996). Li .... The tree distances were generated according to the ClustalW algorithm and the tree was constructed using ... Foundation of China (30871826), China National ''863''.

  8. The investigation of STEM Self-Efficacy and Professional ...

    African Journals Online (AJOL)

    Yi-hui Liu. Chung Hsiao Elementary School, Pingtung County, Taiwan ... STEM project-based learning, using social learning theory (SLT) and SCCT as the ..... platform can include media reports and videos about female engineer role models;.

  9. An Investigation of the Interaction between Resazurin and Cd2+ and ...

    African Journals Online (AJOL)

    NICO

    Yi. * To whom correspondence ... reduction of protonated N-oxide group on the phenoxazin ring. This new irreversible ... resazurin shifted to more positive potential values (about. 50–80 mV) than that of ...

  10. Plasmonic Dye-Sensitized Solar Cells

    KAUST Repository

    Ding, I-Kang; Zhu, Jia; Cai, Wenshan; Moon, Soo-Jin; Cai, Ning; Wang, Peng; Zakeeruddin, Shaik M; Grä tzel, Michael; Brongersma, Mark L.; Cui, Yi; McGehee, Michael D.

    2010-01-01

    reflectors, which consist of 2D arrays of silver nanodomes, can enhance absorption through excitation of plasmonic modes and increased light scattering, as reported by Michael D. McGehee, Yi Cui, and co-workers.

  11. Kosmiline eksimus : Vene kapsel kukkus alla vales kohas / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Vene kosmoseaparaat laskus Kasahstanis kavandatud kohast 420 kilomeetri kaugusele, kuid korealasest teadlane Yi So-yeon, ameeriklasest astronaut Peggy A. Whitson ja venelasest pardainsener Juri Malantshenko pääsesid eluga

  12. Effects of Cypermethrin on Condition factor and Organosomatic ...

    African Journals Online (AJOL)

    KAMAL

    Keywords: Pollution, Fish, Organosomatic-index, Cypermethrin, Sublethal ... related to muscle and livers energy content (Jones et al., 1999; Lizama et al., 2002; Hasan .... physiology (Yi et al., 2007; Ozer et al., 2008; Mlamboo et al., 2009).

  13. Presidential Green Chemistry Challenge: 2012 Greener Synthetic Pathways Award

    Science.gov (United States)

    Presidential Green Chemistry Challenge 2012 award winner, Codexis and Professor Yi Tang, developed a synthesis for the high cholesterol drug, simvastatin, using an engineered acyltransferase enzyme and a low-cost acyl donor as a feedstock.

  14. PREFACE: Preface

    Science.gov (United States)

    Luo, Qingming; Wang, Lihong V.; Tuchin, Valery V.

    2011-02-01

    )Ruey-Jen Sung, Stanford University (USA)A Dean Sherry, The University of Texas at Dallas (USA)Bruce Tromberg, University of California/Irvine (USA)Fujia Yang, Nottingham University (UK)Jianquan Yao, Tianjin University (China)Yixin Zeng, Sun Yat-sen University Cancer Center (China)Baoyong Zheng, Hua Wei Technologies Corporation, Inc (China) Program CommitteeWei R Chen, University of Central Oklahoma (USA)Zhongping Chen, University of California/Irvine (USA)Arthur Chiou, National Yang-Ming University (Taiwan, China)Frank Y S Chuang, University of California, Davis (USA)Zhihua Ding, Zhejiang University (China)Congwu Du, Brookhaven National Laboratory (USA)Stefan Haacke, Strasbourg University - IPCMS-DON (France)Weiping Han, Agency for Science, Technology and Research (A*STAR) (Singapore)Zheng Huang, University of Colorado Health Sciences Center (USA)Zhiwei Huang, National University of Singapore (Singapore)Steven L Jacques, Oregon Health & Science University (USA)Fu-Jen Kao, National Yang-Ming University (Taiwan, China)Hideaki Koizumi, Hitachi, Ltd (Japan)Xingde Li, Johns Hopkins University (USA)Yong-qing Li, East Carolina University (USA)Chengyi Liu, South China Normal University (China)Hong Liu, University of Oklahoma (USA)Zuhong Lu, Southeast University (China)Dennis L Matthews, University of California/Davis (USA)Avraham Mayevsky, Bar Ilan University (Israel)Stephen P Morgan, University of Nottingham (UK)Shoko Nioka, University of Pennsylvania (USA)Yingtian Pan, State University of New York at Stony Brook (USA)Alexander V Priezzhev, MV Lomonosov Moscow State University (Russia)Jianan Y Qu, The Hongkong University of Science and Technology (Hong Kong, China)Colin J R Sheppard, National University of Singapore (Singapore)Mamoru Tamura, Tsinghua University (China)Sergey Ulyanov, Saratov State University (Russia)Ruikang K Wang, Oregon Health & Science University (USA)Xunbin Wei, Fudan University (China)Da Xing, South China Normal University (China)Haishan Zeng, BC Cancer Research

  15. Ethnic Variations in Central Corneal Thickness in a Rural Population in China: The Yunnan Minority Eye Studies

    OpenAIRE

    Pan, Chen-Wei; Li, Jun; Zhong, Hua; Shen, Wei; Niu, Zhiqiang; Yuan, Yuansheng; Chen, Qin

    2015-01-01

    Purpose To describe the ethnic differences in central corneal thickness (CCT) in population-based samples of ethnic Bai, Yi and Han people living in rural China. Methods 6504 adults (2119 ethnic Bai, 2202 ethnic Yi and 2183 ethnic Han) aged 50 years or older participated in the study. Each subject underwent standardized ocular examinations and interviewer-administered questionnaires for risk factor assessment. CCT was measured for both eyes using an ultrasound pachymeter. Regression and princ...

  16. Preemptive Approach to Improving Survival in Epithelial Ovarian Cancer

    Science.gov (United States)

    2012-06-01

    Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M cell...Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M

  17. 飞落在大山深处的彩虹(英文)

    Institute of Scientific and Technical Information of China (English)

    吕枫韵; 黄又璜

    2001-01-01

    Yunnan Province has abundant human, social, ecological and geographical resources. Here 26 ethnic cultures live in harmony with each other. Among these cultures the Yi ethnicity has the largest population and the most branches. They have their own language and writing and have developed unique customs and culture. Dresses are an important part of Yi culture. These garments record the history, religion, totems and folk customs

  18. International Expert - OECD/NEA

    International Nuclear Information System (INIS)

    Yi, Yong Sun

    2009-11-01

    This report was prepared to describe the activities of Yongsun Yi as a technical secretary for the Generation IV VHTR (Very High Temperature Reactor) system. The contents of the report are; i) the GIF (Generation IV International Forum); ii) the GIF governance and technical secretariat; iii) the brief description of the VHTR system iv) the activities of Yongsun Yi as the technical secretary for the VHTR system

  19. Mobile Technology in E-Learning for Undergraduate Medical Education on Emergent Otorhinolaryngology-Head and Neck Surgery Disorders: Pilot Randomized Controlled Trial.

    Science.gov (United States)

    Lee, Li-Ang; Wang, Shu-Ling; Chao, Yi-Ping; Tsai, Ming-Shao; Hsin, Li-Jen; Kang, Chung-Jan; Fu, Chia-Hsiang; Chao, Wei-Chieh; Huang, Chung-Guei; Li, Hsueh-Yu; Chuang, Cheng-Keng

    2018-03-08

    (difference 1.7, 95% CI 0.1-2.7; P=.03), and hedonic stimulation (difference 1.9, 95% CI 0.3-3.1; P=.01) compared with the PPS group. Qualitative feedback indicated that the various games in the IM module attracted the participants' attention but that the nonlinearly arranged materials affected their learning. Using M-TEL for undergraduate medical education on emergent ORL-HNS disorders, an IM module seems to be useful for gaining knowledge, but competency may need to occur elsewhere. While the small sample size reduces the statistical power of our results, its design seems to be appropriate to determine the effects of M-TEL using a larger group. ClinicalTrials.gov NCT02971735; https://clinicaltrials.gov/ct2/show/NCT02971735 (Archived by WebCite at http://www.webcitation.org/6waoOpCEV). ©Li-Ang Lee, Shu-Ling Wang, Yi-Ping Chao, Ming-Shao Tsai, Li-Jen Hsin, Chung-Jan Kang, Chia-Hsiang Fu, Wei-Chieh Chao, Chung-Guei Huang, Hsueh-Yu Li, Cheng-Keng Chuang. Originally published in JMIR Medical Education (http://mededu.jmir.org), 08.03.2018.

  20. Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

    Directory of Open Access Journals (Sweden)

    Wang F

    2015-01-01

    Full Text Available Feng Wang,1,2 Hai Li,3 Xiao-Gang Yan,4 Zhi-Wei Zhou,2 Zhi-Gang Yi,5 Zhi-Xu He,6 Shu-Ting Pan,7 Yin-Xue Yang,3 Zuo-Zheng Wang,1 Xueji Zhang,8 Tianxing Yang,9 Jia-Xuan Qiu,7 Shu-Feng Zhou21Department of Hepatobiliary Surgery, General Hospital, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital, Ningxia Medical University, 4Department of Oncological Surgery, The First People’s Hospital of Yinchuan, 5Department of General Surgery, Changqing Yangehu Hospital, Yinchuan, 6Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 7Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 8Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 9Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USAAbstract: Pancreatic cancer is the most aggressive cancer worldwide with poor response to current therapeutics. Alisertib (ALS, a potent and selective Aurora kinase A inhibitor, exhibits potent anticancer effects in preclinical and clinical studies; however, the effect and underlying mechanism of ALS in the pancreatic cancer treatment remain elusive. This study aimed to examine the effects of ALS on cell growth, autophagy, and epithelial-to-mesenchymal transition (EMT and to delineate the possible molecular mechanisms in human pancreatic cancer PANC-1 and BxPC-3 cells. The results showed that ALS exerted potent cell growth inhibitory, pro-autophagic, and EMT-suppressing effects in PANC-1 and BxPC-3 cells. ALS remarkably arrested PANC-1 and Bx

  1. A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects

    Directory of Open Access Journals (Sweden)

    Zhao SJ

    2017-03-01

    Full Text Available Shao-Jun Zhao,1,2,* De-Hua Wang,1,2 Yan-Wei Li,1,2 Lei Han,1,2 Xing Xiao,1,2 Min Ma,3,* David Chi-Cheong Wan,4 An Hong,1,2 Yi Ma1,2 1Institute of Biomedicine, Department of Cellular Biology, Jinan University, 2National Engineering Research Center of Genetic Medicine, Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, 3College of traditional Chinese Medicine, Institute of Integrated Traditional Chinese and Western Medicine, Jinan University, Guangdong, 4School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China *These authors contributed equally to this work Abstract: A novel neuroendocrine peptide, pituitary adenylate cyclase activating peptide (PACAP, was found to have an important role in carbohydrate or lipid metabolism and was susceptible to dipeptidyl peptidase IV degradation. It can not only mediate glucose-dependent insulin secretion and lower blood glucose by activating VPAC2 receptor, but also raise blood glucose by promoting glucagon production by VPAC1 receptor activation. Therefore, its therapeutic application is restricted by the exceedingly short-acting half-life and the stimulatory function for glycogenolysis. Herein, we generated novel peptide-conjugated selenium nanoparticles (SeNPs; named as SCD, comprising a 32-amino acid PACAP-derived peptide DBAYL that selectively binds to VPAC2, and chitosan-modified SeNPs (SeNPs-CTS, SC as slow-release carrier. The circulating half-life of SCD is 14.12 h in mice, which is 168.4- and 7.1-fold longer than wild PACAP (~5 min and DBAYL (~1.98 h, respectively. SCD (10 nmol/L significantly promotes INS-1 cell proliferation, glucose uptake, insulin secretion, insulin receptor expression and also obviously reduces intracellular reactive oxygen species levels in H2O2-injured INS-1 cells. Furthermore, the biological effects of SCD are stronger than Exendin-4 (a clinically approved drug

  2. MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

    Directory of Open Access Journals (Sweden)

    Yang SW

    2016-06-01

    Full Text Available Shih-Wei Yang,1,* Chi-Ying Tsai,2,* Yi-Chun Pan,3 Chun-Nan Yeh,4 Jong-Hwei S Pang,5 Masashi Takano,6 Atsushi Kittaka,6 Horng-Heng Juang,7 Tai C Chen,8 Kun-Chun Chiang4,9 1Department of Otolaryngology – Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, 2Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Taoyuan, 3Department of General Dentistry, Chang Gung Memorial Hospital, Chang Gung University, Keelung, 4General Surgery Department, Chang Gung Memorial Hospital, Keelung, 5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 6Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan; 7Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 8Endocrine Core Laboratory, Boston University School of Medicine, Boston, MA, USA; 9Zebrafish Center, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China *These authors contributed equally to this work Abstract: Even with multidisciplinary treatment, the prognosis and quality of life of patients diagnosed with head and neck squamous cell carcinoma (HNSCC are still not satisfactory. Previously, 19-Nor-2α-(3-hydroxypropyl-1α,25(OH2D3 (MART-10, the new brand 1α,25(OH2D3 analog, has been demonstrated to be an effective drug to inhibit HNSCC growth in vitro. Since most cancer patients die of metastasis, in this study, the antimetastatic effect of MART-10 on HNSCC was investigated. Our results reveal that both 1α,25(OH2D3 and MART-10 effectively repressed the migration and invasion of HNSCC cells, with MART-10 being much more potent than 1α,25(OH2D3. The antimetastatic effect of 1α,25(OH2D3 and MART-10 was mediated by attenuation of epithelial–mesenchymal transition (EMT, which was supported by the finding that the expression of EMT-inducing transcriptional factors, Sail and Twist, was inhibited by 1α,25(OH2D3 and MART

  3. Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Jiang Y

    2014-01-01

    Full Text Available Yan Jiang,1,* Zhen-Lin Zhang,2,* Zhong-Lan Zhang,3 Han-Min Zhu,4 Yi-Yong Wu,5 Qun Cheng,4 Feng-Li Wu,5 Xiao-Ping Xing,1 Jian-Li Liu,3 Wei Yu,6 Xun-Wu Meng11Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 2Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 3Department of Gynecology and Obstetrics, General Hospital of the People's Liberation Army, Beijing, 4Department of Geriatrics, Shanghai Huadong Hospital, Shanghai, 5Department of Gynecology and Obstetrics, Beijing Hospital, Ministry of Public Health, Beijing, 6Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China*These authors contributed equally to this workObjective: To evaluate whether the efficacy and safety of menatetrenone for the treatment of osteoporosis is noninferior to alfacalcidol in Chinese postmenopausal women.Method: This multicenter, randomized, double-blinded, double-dummy, noninferiority, positive drug-controlled clinical trial was conducted in five Chinese sites. Eligible Chinese women with postmenopausal osteoporosis (N=236 were randomized to Group M or Group A and received menatetrenone 45 mg/day or alfacalcidol 0.5 µg/day, respectively, for 1 year. Additionally, all patients received calcium 500 mg/day. Posttreatment bone mineral density (BMD, new fracture onsets, and serum osteocalcin (OC and undercarboxylated OC (ucOC levels were compared with the baseline value in patients of both groups.Results: A total of 213 patients (90.3% completed the study. After 1 year of treatment, BMD among patients in Group M significantly increased from baseline by 1.2% and 2.7% at the lumbar spine and trochanter, respectively (P<0.001; and the percentage increase of BMD in Group A was 2

  4. Analysis of pramipexole dose–response relationships in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Wang Y

    2016-12-01

    Full Text Available Ying Wang,1 Sheng-Gang Sun,2 Sui-Qiang Zhu,3 Chun-Feng Liu,4 Yi-Ming Liu,5 Qing Di,6 Hui-Fang Shang,7 Yan Ren,8 Wei Xiang,9 Sheng-Di Chen1 1Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 2Department of Neurology, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 3Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 4Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 5Department of Neurology, Qilu Hospital Affiliated to Shandong University, Jinan, 6Department of Neurology, Nanjing Brain Hospital, Nanjing, 7Department of Neurology, West China Hospital Affiliated to Sichuan University, Chengdu, 8Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, 9Medical Department, Boehringer Ingelheim (China Investment Co., Ltd., Shanghai, People’s Republic of China Background: Pramipexole (PPX, a non-ergot dopamine receptor agonist, is a first-line treatment for Parkinson’s disease (PD. A critical dose level above which a better benefit-to-harm ratio exists has not been examined.Methods: Chinese PD patients (n=464 were retrospectively analyzed by PPX maintenance dose, PD stage, combined levodopa dose, and baseline tremor contribution. The sum score of Baseline Activities of Daily Living (part II and Motor Examination (III of the Unified Parkinson’s Disease Rating Scale (UPDRS II+III was used as a covariate for final score adjustment.Results: Sustained-release (SR and immediate-release (IR PPX showed similar efficacy based on score changes at 18 weeks, with comparable tolerability. Approximately two-third of patients received PPX at ≥1.5 mg/d, and one fourth of patients had ≥20% tremor contribution to UPDRS II+III. After treatment, patients receiving PPX ≥1.5 mg/d showed

  5. Comparison of spontaneous brain activity revealed by regional homogeneity in AQP4-IgG neuromyelitis optica-optic neuritis versus MOG-IgG optic neuritis patients: a resting-state functional MRI study

    Directory of Open Access Journals (Sweden)

    Wang J

    2017-10-01

    Full Text Available Junqing Wang,1,* Yuan Tian,2,* Yi Shao,3,* Hui Feng,1 Limin Qin,1 Weiwei Xu,1 Hongjuan Liu,1 Quangang Xu,1 Shihui Wei,1 Lin Ma2 1Department of Ophthalmology, 2Department of Radiology, Chinese PLA General Hospital, Beijing, 3Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: Many previous studies have demonstrated that neuromyelitis optica (NMO patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG-IgG ON and aquaporin 4(AQP4-neuromyelitis optica-optic neuritis (ON remain unknown. In the current study, we investigated the brain neural homogeneity in MOG-IgG ON versus AQP4-IgG NMO-ON subjects by regional homogeneity (ReHo method using magnetic resonance imaging (MRI. Patients and methods: A total of 32 NMO-ON and ON subjects (21 with AQP4-IgG+NMO-ON and 11 with MOG-IgG+ON and 34 healthy controls (HCs closely matched for age were recruited, and scans were performed for all subjects. A one-way analysis of variance (ANOVA was performed to determine the regions in which the ReHo was different across the three groups. NMO-ON and ON subjects were distinguished from HCs by a receiver operating characteristic (ROC curve. The relationship between the mean ReHo in many brain regions and clinical features in NMO subjects was calculated by Pearson correlation analysis. Results: Compared with HCs, MOG-IgG+ON subjects had significantly decreased ReHo values in the posterior lobe of the left cerebellum and increased ReHo values in the left inferior frontal gyrus, right prefrontal gyrus, and left precentral/postcentral gyrus. AQP4-IgG+NMO-ON subjects showed higher ReHo values in the left inferior frontal gyrus and right middle temporal/occipital gyrus. Compared with MOG-IgG+ON subjects, AQP4-IgG+NMO-ON subjects had lower Re

  6. Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid–paclitaxel (CLA-PTX on B16-F10 melanoma

    Directory of Open Access Journals (Sweden)

    Du R

    2014-06-01

    Full Text Available Ruo Du,1 Ting Zhong,1 Wei-Qiang Zhang,1 Ping Song,1 Wen-Ding Song,1 Yang Zhao,1 Chao-Wang,1 Yi-Qun Tang,3 Xuan Zhang,1,2 Qiang Zhang1,2 1Department of Pharmaceutics, 2State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 3Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China Abstract: In the present study, we prepared a novel delivery system of iRGD (CRGDK/RGPD/EC-modified sterically stabilized liposomes (SSLs containing conjugated linoleic acid–paclitaxel (CLA-PTX. The anti-tumor effect of iRGD-SSL-CLA-PTX was investigated on B16-F10 melanoma in vitro and in vivo. The in vitro targeting effect of iRGD-modified SSLs was investigated in a real-time confocal microscopic analysis experiment. An endocytosis-inhibition assay was used to evaluate the endocytosis pathways of the iRGD-modified SSLs. In addition, the in vitro cellular uptake and in vitro cytotoxicity of iRGD-SSL-CLA-PTX were evaluated in B16-F10 melanoma cells. In vivo biodistribution and in vivo antitumor effects of iRGD-SSL-CLA-PTX were investigated in B16-F10 tumor-bearing mice. The induction of apoptosis by iRGD-SSL-CLA-PTX was evaluated in tumor-tissue sections. Real-time confocal microscopic analysis results indicated that the iRGD-modified SSLs internalized into B16-F10 cells faster than SSLs. The identified endocytosis pathway of iRGD-modified SSLs indicated that energy- and lipid raft-mediated endocytosis played a key role in the liposomes’ cellular uptake. The results of the cellular uptake experiment indicated that the increased cellular uptake of CLA-PTX in the iRGD-SSL-CLA-PTX-treated group was 1.9-, 2.4-, or 2.1-fold compared with that in the CLA-PTX group after a 2-, 4-, or 6-hour incubation, respectively. In the biodistribution test, the CLA-PTX level in tumor tissues from iRGD-SSL-CLA-PTX-treated mice at 1 hour (1.84±0.17 µg/g and 4 hours (1.17±0

  7. Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy

    Directory of Open Access Journals (Sweden)

    Wu JY

    2018-03-01

    Full Text Available Jun-Yi Wu,1,* Zhong-Xia Wang,1,* Guang Zhang,1 Xian Lu,1 Guang-Hui Qiang,2 Wei Hu,2 An-Lai Ji,3 Jun-Hua Wu,4 Chun-Ping Jiang1 1Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; 2Department of Hepatobiliary Surgery, Drum Tower Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; 3Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China; 4Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, Jiangsu, China *These authors contributed equally to this work Purpose: FTY720, known as fingolimod, is a new immunosuppressive agent with effective anticancer properties. Although it was recently confirmed that FTY720 inhibits cancer cell proliferation, FTY720 can also induce protective autophagy and reduce cytotoxicity. Blocking autophagy with Beclin 1 siRNA after treatment with FTY720 promotes apoptosis. The objective of this study was to enhance the anticancer effect of FTY720 in hepatocellular carcinoma (HCC by targeted co-delivery of FTY720 and Beclin 1 siRNA using calcium phosphate (CaP nanoparticles (NPs.Materials and methods: First, the siRNA was encapsulated within the CaP core. To form an asymmetric lipid bilayer structure, we then used an anionic lipid for the inner leaflet and a cationic lipid for the outer leaflet; after removing chloroform by rotary evaporation, these lipids were dispersed in a saline solution with FTY720. The NPs were analyzed by transmission electron microscopy, dynamic light scattering and ultraviolet–visible spectrophotometry. Cancer cell viability and cell death were analyzed by MTT assays, fluorescence-activated cell sorting analysis and Western blotting. In addition, the in vivo effects of the NPs were investigated using an athymic nude mouse subcutaneous transplantation tumor model.Results: When the CaP NPs, called

  8. Baicalein improves behavioral dysfunction induced by Alzheimer’s disease in rats

    Directory of Open Access Journals (Sweden)

    Zhou L

    2016-12-01

    Full Text Available Li Zhou, Sha Tan, Yi-long Shan, Yu-ge Wang, Wei Cai, Xue-hong Huang, Xi-yuan Liao, Hai-yan Li, Lei Zhang, Bing-jun Zhang, Zheng-qi Lu Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China Background: Alzheimer’s disease (AD is considered to be a neurodegenerative disorder that is characterized by increased oxidative stress. Medicinal plants, with their antioxidant properties, have been used to cure several human diseases. The aim of the current study was to explore the protective and therapeutic effect of baicalein on AD-induced rats. Materials and methods: Swiss Wistar rats were used in the study. The rats were divided into five groups. Group I: normal control group treated with water; Group II: disease control treated with AlCl3 to induce the mimicking AD for 4 successive weeks (SW; Group III: normal control group treated with baicalein (5 mg/kg for 2 SW followed by combination of baicalein and AlCl3­ for 4 SW; Group IV: normal control group treated with baicalein (10 mg/kg for 2 SW followed by combination of baicalein and AlCl3 for 4 SW; Group V: normal control group treated with rivastigmine (0.3 mg/kg for 2 SW followed by combination of rivastigmine and AlCl3 for 4 SW. Moreover, the therapeutic groups are as follows: Group VI: AD disease control treated with AlCl3 for 4 SW and serving as the therapeutic positive group; Group VII: AD disease control + baicalein (5 mg/kg for 12 SW; Group VIII: AD disease control + baicalein (10 mg/kg for 12 SW; Group IX: AD disease control + rivastigmine (0.3 mg/kg for 12 SW. Behavioral test, T-maze, and rotarod test were also performed before and after the treatment. At the end of the experimental study, all the rats were sacrificed and their brains were removed and divided into two portions. The first portion was homogenated for estimating the level of acetylcholinesterase (AchE and acetylcholine (Ach. Another portion was used

  9. Not Congruent but Quite Complementary: U.S. and Chinese Approaches to Nontraditional Security

    Science.gov (United States)

    2012-07-01

    Path of Peaceful Development (2005–2006), Chinese leaders con- nected reduction of terrorism, financial risk, and natural disasters to the maintenance ...the Darfur issue. . . . Both the United States and China have a continuing interest in the maintenance of peace and stability in the wider region.”34...East Turkestan], CCTV News, news.cctv.com/. 15. Yao Yao, “对我国反恐情报工作的思考—从 孟买恐怖袭击反思中国的反恐情报工作” [Reflections on Intelligence Work on China’s

  10. Convergence Theorem for Equilibrium and Variational Inequality Problems and a Family of Infinitely Nonexpansive Mappings in Hilbert Space

    Directory of Open Access Journals (Sweden)

    Zhou Yinying

    2014-01-01

    Full Text Available We introduce a hybrid iterative scheme for finding a common element of the set of common fixed points for a family of infinitely nonexpansive mappings, the set of solutions of the varitional inequality problem and the equilibrium problem in Hilbert space. Under suitable conditions, some strong convergence theorems are obtained. Our results improve and extend the corresponding results in (Chang et al. (2009, Min and Chang (2012, Plubtieng and Punpaeng (2007, S. Takahashi and W. Takahashi (2007, Tada and Takahashi (2007, Gang and Changsong (2009, Ying (2013, Y. Yao and J. C. Yao (2007, and Yong-Cho and Kang (2012.

  11. The Ancestors’ Legend

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The Fairy Lady of Wushan Mountain Yao Ji, youngest daughter of Emperor Yandi, sent to thesouth of Wushan Mountain in the Three Gorges, was named theFairy Lady of Wushan Mountain. When King Chu Huaiwangwas on a tour to Gaotang. he dreamed of the fair lady. Later,when King Chu Xiangwang was on the same tour, he too mether in a dream. Yao Ji grew a majestic plant, plucked it andmade it an iris. It was said that if stewed and eaten, the one whoate may chance to meet their lover in their dreams.

  12. Stemcell Information: SKIP000866 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  13. Stemcell Information: SKIP000868 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  14. Stemcell Information: SKIP000869 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  15. Stemcell Information: SKIP000867 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  16. Study on radiation discoloration of PE and its mechanisms

    International Nuclear Information System (INIS)

    Wang Huiliang; Wang Chun; Chen Wenxiu

    2001-01-01

    In order to find the major reason for the radiation discoloration of PE, the changes of yellow index (YI) of HDPE and LDPE under γ irradiation in air or N 2 and after irradiation are measured using colorimeter. The growth and decay of alkyl free radical formed in HDPE and LDPE, and the change of the absorbance of conjugated double bonds formed in PE are measured using ESR and UV-Visible spectrometer. The YI of HDPE is higher than that of LDPE at the same radiation dose. The YI of PE irradiated in air is higher than that of PE irradiated in N 2 at the same radiation dose. The YI of PE irradiated different dose decreases with post-irradiation storage time firstly, up to a certain time, it becomes stable. It is found that the formation and decay of free radicals is very similar to that of the change of YI, whereas, the change of the absorbance of conjugated double bonds formed in PE is different to the change of YI. The results are discussed, it is believed that the major reason for the radiation discoloration is the formation of trapped free radicals

  17. Editorial: Focus on Laser- and Beam-Driven Plasma Accelerators

    Science.gov (United States)

    Joshi, Chan; Malka, Victor

    2010-04-01

    , S Mangles, L O Silva, R Fonseca and P A Norreys Electro-optic shocks from blowout laser wakefields D F Gordon, A Ting, M H Helle, D Kaganovich and B Hafizi Onset of self-steepening of intense laser pulses in plasmas J Vieira, F Fiúza, L O Silva, M Tzoufras and W B Mori Analysis of laser wakefield dynamics in capillary tubes N E Andreev, K Cassou, F Wojda, G Genoud, M Burza, O Lundh, A Persson, B Cros, V E Fortov and C-G Wahlstrom Characterization of the beam loading effects in a laser plasma accelerator C Rechatin, J Faure, X Davoine, O Lundh, J Lim, A Ben-Ismaïl, F Burgy, A Tafzi, A Lifschitz, E Lefebvre and V Malka Energy gain scaling with plasma length and density in the plasma wakefield accelerator P Muggli, I Blumenfeld, C E Clayton, F J Decker, M J Hogan, C Huang, R Ischebeck, R H Iverson, C Joshi, T Katsouleas, N Kirby, W Lu, K A Marsh, W B Mori, E Oz, R H Siemann, D R Walz and M Zhou Generation of tens of GeV quasi-monoenergetic proton beams from a moving double layer formed by ultraintense lasers at intensity 1021-1023Wcm-2 Lu-Le Yu, Han Xu, Wei-Min Wang, Zheng-Ming Sheng, Bai-Fei Shen, Wei Yu and Jie Zhang Carbon ion acceleration from thin foil targets irradiated by ultrahigh-contrast, ultraintense laser pulses D C Carroll, O Tresca, R Prasad, L Romagnani, P S Foster, P Gallegos, S Ter-Avetisyan, J S Green, M J V Streeter, N Dover, C A J Palmer, C M Brenner, F H Cameron, K E Quinn, J Schreiber, A P L Robinson, T Baeva, M N Quinn, X H Yuan, Z Najmudin, M Zepf, D Neely, M Borghesi and P McKenna Numerical modelling of a 10-cm-long multi-GeV laser wakefield accelerator driven by a self-guided petawatt pulse S Y Kalmykov, S A Yi, A Beck, A F Lifschitz, X Davoine, E Lefebvre, A Pukhov, V Khudik, G Shvets, S A Reed, P Dong, X Wang, D Du, S Bedacht, R Zgadzaj, W Henderson, A Bernstein, G Dyer, M Martinez, E Gaul, T Ditmire and M C Downer Effects of laser prepulses on laser-induced proton generation D Batani, R Jafer, M Veltcheva, R Dezulian, O Lundh, F Lindau, A

  18. Ideede paraad Zürichis / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2000-01-01

    Üleeuroopaline noorte moeloojate etendus Barclay-Catwalk Zürichis ja Rotterdamis. Uued nimed: Wei Gao, Natasha ja Tamara Surguladze, Jacqueline Burtsche, Tom Notte, Jessy Heuvelink, Daniel Controversio jt.

  19. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Li Wei1 2 Cheng Pengfei2 Bei Jinzhong2 Wen Hanjiang2 Wang Hua1 2. School of Geodesy and Geomatics, Wuhan University, Wuhan 430 079, China. Chinese Academic of Surveying and Mapping, Beijing 100 830, China.

  20. Modulation instability of an intense laser beam in an unmagnetized ...

    Indian Academy of Sciences (India)

    Author Affiliations. San Qiu Liu1 Wei Tang1 Xiao Qing Li1 2. Department of Physics, Nanchang University, Nanchang 330047, People's Republic of China; Department of Physics, Nanjing Normal University, Nanjing 210097, People's Republic of China ...

  1. African Journal of Biotechnology - Vol 12, No 31 (2013)

    African Journals Online (AJOL)

    induced fatty liver model of consecutive extracts from Rosa davurica Pall · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ying Wei, Muyi Cai, Ruizeng Gu, Jun Lu, Feng Lin, Baoping Ji ...

  2. Combat Power Analysis is Combat Power Density

    Science.gov (United States)

    2012-05-17

    Lanchester equations, Weapon Effectiveness Index (WEI), Weighted Unit Value (WUV), Armored Division Equivalents (ADE), and Unit Frontages. The research...6 Lanchester Equations... Lanchester Equations ............................................................................................... 53 Appendix C: Relative Combat Power

  3. Quantum Fisher information on its own is not a valid measure of the coherence

    Science.gov (United States)

    Kwon, Hyukjoon; Tan, Kok Chuan; Choi, Seongjeon; Jeong, Hyunseok

    2018-06-01

    We show that contrary to the claim in Feng and Wei (2017), the quantum Fisher information itself is not a valid measure of the coherence based on the resource theory because it can increase via an incoherent operation.

  4. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Dong Jun Jee1 Tuo Yeong Lee1 Nathaniel Zhi-Wei Leon1. Department of Mathematics, Statistics and Computing, NUS High School of Mathematics and Science, 20 Clementi Avenue 1, Singapore 129957, Republic of Singapore ...

  5. Reference: 352 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available |Holtkamp Volker|Issakidis-Bourguet Emmanuelle|Kandlbinder Andrea|Lamkemeyer Petra|Laxa Miriam|Li Wenxue|Miginiac-Maslow Myroslawa|Schöttler Mark A|Tognetti Vanesa B|Weis Engelbert

  6. Video Gaming Let the Games Begin After years of hesitation, Microsoft and Sony may at last introduce their latest gaming products to the Chinese market

    Institute of Scientific and Technical Information of China (English)

    MICHAEL O'NEILL

    2006-01-01

    @@ Arough, handwritten sign hangs in the window of Ding Wei's shoebox sized video game store,one of a dozen or so similar outlets located in the warren of small lanes in the shadow of Beijing's ancient Bell Tower.

  7. 76 FR 10593 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-25

    ... Individual), Steven L. Leturno, Director, Application Type: QI Change. Combined Freight System, Inc. (NVO...), 148-08 Guy R. Brewer Blvd., Jamaica, NY 11434, Officers: Wei Hu, Vice President, (Qualifying...

  8. Effects of temperature, light, desiccation and cold storage on ...

    African Journals Online (AJOL)

    oyaide

    2015-03-25

    Mar 25, 2015 ... conservation (Hong and Ellis, 1996; Linington and. Pritchard, 2001). .... Taking into account final mean germination percentages ... Guo from the Center for Conservation of Medicinal. Plants ... Ma QY, Wei Z (1994). Flora of ...

  9. Productivity Effects of United States Multinational Enterprises : The Roles of Market Orientation and Regional Integration

    NARCIS (Netherlands)

    Smeets, Roger; Wei, Yingqi

    2010-01-01

    Smeets R. and Wei Y. Productivity effects of United States multinational enterprises: the roles of market orientation and regional integration, Regional Studies. This paper considers the role of market orientation and regional integration in foreign direct investment (FDI) productivity effects.

  10. 76 FR 45615 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-07-29

    ... capabilities and components thereof. The complaint names as respondents Huawei Technologies Co., Ltd. of China; FutureWei Technologies, Inc. d/b/a Huawei Technologies (USA) of TX; Nokia Corporation of Finland; Nokia...

  11. Peripheral nerve blocks versus general anesthesia for total knee replacement in elderly patients on the postoperative quality of recovery

    OpenAIRE

    Hong, Zhang; Wang,Mingjun; Yuan,Weixiu; Wang,Xiaolin; Maowei,Gong; Gong,Maowei; Zhao,Yi

    2014-01-01

    JunLe Liu,1,* WeiXiu Yuan,1,* XiaoLin Wang,1,* Colin F Royse,2,3 MaoWei Gong,1 Ying Zhao,1 Hong Zhang1 1Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital and Medical School of Chinese People's Liberation Army, Beijing, People's Republic of China; 2Anesthesia and Pain Management Unit, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia; 3Department of Anesthesia and Pain Management, The Royal Melbourne Hospital...

  12. Laryngoscope and a new tracheal tube assist lightwand intubation in difficult airways due to unstable cervical spine.

    Directory of Open Access Journals (Sweden)

    Cai-neng Wu

    Full Text Available The WEI Jet Endotracheal Tube (WEI JET is a new tracheal tube that facilitates both oxygenation and ventilation during the process of intubation and assists tracheal intubation in patients with difficult airway. We evaluated the effectiveness and usefulness of the WEI JET in combination with lightwand under direct laryngoscopy in difficult tracheal intubation due to unstable cervical spine.Ninety patients with unstable cervical spine disorders (ASA I-III with general anaesthesia were included and randomly assigned to three groups, based on the device used for intubation: lightwand only, lightwand under direct laryngoscopy, lightwand with WEI JET under direct laryngoscopy.No statistically significant differences were detected among three groups with respect to demographic characteristics and C/L grade. There were statistically significant differences between three groups for overall intubation success rate (p = 0.015 and first attempt success rate (p = 0.000. The intubation time was significantly longer in the WEI group (110.8±18.3 s than in the LW group (63.3±27.5 s, p = 0.000 and DL group (66.7±29.4 s, p = 0.000, but the lowest SpO2 in WEI group was significantly higher than other two groups (p<0.01. The WEI JET significantly reduced successful tracheal intubation attempts compared to the LW group (p = 0.043. The severity of sore throat was similar in three groups (p = 0.185.The combined use of WEI JET under direct laryngoscopy helps to assist tracheal intubation and improves oxygenation during intubation in patients with difficult airway secondary to unstable spine disorders.Chinese Clinical Trial Registry ChiCTR-TRC-14005141.

  13. A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system

    OpenAIRE

    Wang, Shaowei; Wei, Xiaochun; Sun, Xiaojuan; Chen, Chongwei; Zhou, Jingming; Zhang, Ge; Wu, Heng; Guo, Baosheng; Wei, Lei

    2018-01-01

    Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA; 3Integrated Traditional Chinese and Western Medicine, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Background: C...

  14. Spinning droplets: non-first generation East and Southeast Asian Australian poets and the discourse of water

    OpenAIRE

    McFarlane, Rosalind Nicole

    2017-01-01

    Poetry written by diasporic Asian groups in Australia has been gaining increasing attention, especially with the 2013 release of Contemporary Asian Australian Poets edited by Adam Aitken, Kim Cheng Boey and Michelle Cahill, the first anthology of this kind of work. This thesis aims to be the first instance of sustained critical attention paid to many of the poets included in this anthology, including Adam Aitken, Ivy Alvarez, Lachlan Brown, Lily Chan, Bella Li, Debbie Lim, Miriam Wei Wei Lo, ...

  15. Aerodynamic models for high-amplitude, low reynolds flapping airfoils

    OpenAIRE

    Morales Tirado, Elisa

    2015-01-01

    In this thesis a new aerodynamic model of insect-like flapping flight for micro air vehicles has been developed. The New Predicted Aerodynamic Model (NPAM) was based on the model described by Weis-Fogh model in Energetics of Hovering Flight in Hummingbirds and Drosophila. In order to achieved the NPAM some variations were introduced regarding the geometry of the problem under study and also some improvements was done to the theory developed by Weis-Fogh. To have the required ...

  16. Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-? for infantile hemangioma

    OpenAIRE

    Zhang, Ling; Wu, Hai Wei; Yuan, Weien; Zheng, Jia Wei

    2017-01-01

    Ling Zhang,1 Hai Wei Wu,1 Weien Yuan,2 Jia Wei Zheng1 1Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Background: Infantile hemangiomas (IHs) are the most common benign vascular tumor of infancy. They occur more frequently in female infants....

  17. Power Spectrum Density of Stochastic Oscillating Accretion Disk GB ...

    Indian Academy of Sciences (India)

    J., 672, 40. Harko, T., Mocanu, G. R. 2012, Mon. Not. R. Astron. Soc., 421, 3102. Jauncey, D. L., Macquart, J. P. 2001, Astron. Astrophys., 370, L9. Kato, S. 2001, Publ. Astron. Soc. Jpn., 53, 1. Leung, C. S., Wei, J. Y., Harko, T. et al. 2011a, J. Astrophys. Astr., 32, 189. Leung, C. S., Wei, J. Y., Kovacs, Z. et al. 2011b, Res. Astron.

  18. Review and Study of Physics Driven Pitting Corrosion Modeling in 2024-T3 Aluminum Alloys (Postprint)

    Science.gov (United States)

    2015-05-01

    aluminum subjected to pitting corrosion under fatigue conditions ”, Journal of Aircraft, Vol. 46, No. 4, pp. 1253-1259 Wei, R.P. (2001) “A model for...and material microstructure applied to corrosion and fatigue of aluminum and steel alloys”, Engineering Fracture Mechanics , Vol. 76, pp. 695-708 Wei...Fatigue Behavior of Aluminum Alloy 7075 -T6: Modeling and Experimental Studies", Materials Science and Engineering: A, vol. 297, Issue: 1-2, 15, pp. 223

  19. RLE (Research Laboratory of Electronics) Progress Report Number 130

    Science.gov (United States)

    1988-07-01

    Ippen, James G. Fujimoto, Wei-Zhu Lin, Beat Zysset, Robert W. Schoenlein, 4 Michael J. Lagasse The investigation of transient carrier dynamics in GaAs...G. Fujimoto, Wei-Zhu Lin, Reginald Birngruber, Beat Zysset, Robert W. Schoenleln Working in collaboration with researchers at the Massachusetts Eye... Binaural Hearing National Institutes of Health (Grant 5 RO 1 NS 10916) H. Steven Colburn, Nathaniel 1. Durlach, Patrick M. Zurek 17 Brooklyn College14 141

  20. PREFACE International Symposium on Spintronic Devices and Commercialization 2010

    Science.gov (United States)

    Du, You-wei; Judy, Jack; Qian, Zhenghong; Wang, Jianping

    2011-01-01

    very successful indeed. We are also grateful to the Advisory Committee, the Conference Chairs, the Excutive Chairs, the Academic Committee, the Organization Committee and the Secretariat for their fruitful work. We would especially like to thank all the organizers listed below for their support in all aspects of the conference. We would like to express our thanks to all the authors for their time and genuine efforts, and to the reviewers for their fruitful comments during the preparation of this volume. ISSDC'2010 ORGANIZATION Advisory Committee Chialing Chien, USAJunhao Chu, ChinaBernard Dieny, FranceKoichiro Inomata, Japan Liangmo Mei, ChinaJohn Sivertsen, USAMingjing Tu, ChinaDingsheng Wang, China Zhanguo Wang, ChinaQikun Xue, ChinaWenshan Zhan, China Conference Chairs Jack Judy, USAYouwei Du, China Executive Chairs Zhenghong Qian, USAJianping Wang, USA Organization Committee ChairJiyan Luo, China Vice ChairsGuilin Duan, ChinaLingling Sun, ChinaBaogen Shen, China MembersTiecheng Lu, ChinaDa Ma, ChinaYe Tian, China Jinsong Xu, ChinaQiuling XuChangmao Yang, China Guanghua Yu, ChinaYi Yan, China Academic Committee ChairsZhenghong Qian, USAYongbing Xu, UK Vice ChairsSeongtae Bae, SingaporeYong Jiang, ChinaDexin Wang, USA Huaiwu Zhang, ChinaJianhua Zhao, China MembersJianwang Cai, ChinaXiangdong Chen, ChinaHaifeng Ding, China Chunhong Hou, USAGunther Baubock, USABin Hu, USA Jungchun Huang, TaiwanDexuan Huo, ChinaYoon H Jeong, Korea Chihuang Lai, TaiwanRunwei Li, ChinaWei Liu, China Jing Shi, USAYasushi Takemura, JapanMark Tondra, USA Shan X Wang, USADi Wu, ChinaDesheng Xue, China Minglang Yan, USAShishen Yan, ChinaXiaofei Yang, China Chun Yeol You, KoreaWei Zhao, ChinaShiming Zhou, China Jianguo Zhu, China Secretariat Secretary-generalChangmao Yang, China Vice Secretary-generalJunli Wang, ChinaJinsong Xu, ChinaYe Tian, China MembersRu Bai, ChinaHongliang Zhan, China ISSDC' 2010 Organizers Department of Science and Technology, CSIC, China SpinIC Inc., China Hangzhou

  1. An authentication scheme for secure access to healthcare services.

    Science.gov (United States)

    Khan, Muhammad Khurram; Kumari, Saru

    2013-08-01

    Last few decades have witnessed boom in the development of information and communication technologies. Health-sector has also been benefitted with this advancement. To ensure secure access to healthcare services some user authentication mechanisms have been proposed. In 2012, Wei et al. proposed a user authentication scheme for telecare medical information system (TMIS). Recently, Zhu pointed out offline password guessing attack on Wei et al.'s scheme and proposed an improved scheme. In this article, we analyze both of these schemes for their effectiveness in TMIS. We show that Wei et al.'s scheme and its improvement proposed by Zhu fail to achieve some important characteristics necessary for secure user authentication. We find that security problems of Wei et al.'s scheme stick with Zhu's scheme; like undetectable online password guessing attack, inefficacy of password change phase, traceability of user's stolen/lost smart card and denial-of-service threat. We also identify that Wei et al.'s scheme lacks forward secrecy and Zhu's scheme lacks session key between user and healthcare server. We therefore propose an authentication scheme for TMIS with forward secrecy which preserves the confidentiality of air messages even if master secret key of healthcare server is compromised. Our scheme retains advantages of Wei et al.'s scheme and Zhu's scheme, and offers additional security. The security analysis and comparison results show the enhanced suitability of our scheme for TMIS.

  2. Zhang et al., Afr J Tradit Complement Altern Med. (2014) 11(6):66-76

    African Journals Online (AJOL)

    cadewumi

    So DNA barcodes for identifying herbal materials should have great usability and variation. Previous data suggested that ITS2 represented the most suitable region for DNA barcoding applications so it was proposed as a novel universal barcode for herbal materials (Chen et al.,. 2010, 2013; Yao et al., 2010). Until now, the ...

  3. Etude de la diversité, de l'endémisme et de la distribution spatiale ...

    African Journals Online (AJOL)

    ,. 96(1):. 1-11. DOI: 10.3417/2006205. Denguéadhé KTS, Decocq G, Adou Yao CY,. Blom EC, Van Rompaey RSAR. 2006. Plant species diversity in the southern part of the Taï National Parc (Côte d'Ivoire). Biodiversity and Conservation,.

  4. Analysis of regulatory networks constructed based on gene ...

    Indian Academy of Sciences (India)

    2013-12-09

    Dec 9, 2013 ... early diagnosis of complex diseases or cancer without obvious symptoms. [Gong J., Diao B., Yao G. J., ... expression levels of thousands of genes in a specific cell or tissue. Previous ..... base of the brain. It mainly controls the ...

  5. Decidability Issues for Extended Ping-Pong Protocols

    DEFF Research Database (Denmark)

    Huttel, Hans; Srba, Jiri

    2006-01-01

    We use some recent techniques from process algebra to draw several conclusions about the well studied class of ping-pong protocols introduced by Dolev and Yao. In particular we show that all nontrivial properties, including reachability and equivalence checking wrt. the whole van Glabbeek...

  6. Separation of Armchair SWNTs by Using Polymer Conformation Guided Assembly

    Science.gov (United States)

    2013-08-22

    Chan-Park, M. B. Diameter- and Metallicity-Selective Enrichment of Single-Walled Carbon Nanotubes Using Polymethacrylates with Pendant Aromatic...Emitting PPE-PPV Hybrid Polymers: Efficient Energy Transfer across the m-Phenylene Bridge . Macromolecules 2003, 36, 3848-3853. 34. Yao, J.; Chen, Y

  7. DNA methylation of PTEN gene promoter region is not correlated ...

    African Journals Online (AJOL)

    Yomi

    2012-02-23

    Feb 23, 2012 ... of Shandong, Qingdao Agricultural University, Qingdao, 266109, China. 2Daping ... (Kang et al., 2002), glioblastoma (Baeza et al., 2003), breast cancer ... DNA isolation by using micro DNA isolation kit (Tiangen, Beijing,. China) .... Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA (2004). The PI.

  8. Cloning and characterization of peptidylprolyl isomerase B in the ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-12-15

    Dec 15, 2009 ... 1Institute of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, P. R. China. 2Beijing ... 6 Tianshuiyuan Street, Chaoyang District, Beijing 100026, P. R. China. ... Kang et al., 2008). Cyclophilins were ..... Xu YX, Manley JL (2007). ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (2005).

  9. One new species of Amphinemura and description of the female of A. ancistroidea Li & Yang (Plecoptera: Nemouridae) from Guangxi Zhuang Autonomous Region of southern China.

    Science.gov (United States)

    Mo, Raorao; Yang, Ding; Wang, Guoquan; Li, Weihai

    2017-06-11

    A new nemourid species, Amphinemura yao sp. nov. is described from the Daoyao Mountains of Guangxi Zhuang Autonomous Region of southern China. Amphinemura ancistroidea Li & Yang, 2007 is newly recorded from Guangxi and the female is described for the first time including the internal vaginal complex. The new species is compared with related taxa.

  10. New species and records of the stonefly genus Neoperla (Plecoptera, Perlidae) from Jinhuacha Nature Reserve, Guangxi of China.

    Science.gov (United States)

    Wang, Guo-Quan; Li, Wei-Hai; Yang, Juan

    2013-01-01

    Two new Neoperla species (Neoperla mesospina, Neoperla latispina) are described from the adult male stage from the Jinhuacha Nature Reserve, Guangxi of China. The new species are compared with similar taxa. Taxonomic remarks are also provided for N. transversprojecta Du & Sivec and N. yao Stark. The latter species is newly recorded for Guangxi.

  11. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    KOUAME1*, Guy Fernand YAO2, .... activités de prospection et d'exploitation minière. On note toutefois la présence de forêt galerie, ..... fonction de la variation de pente sur les versants, comporte une différence significative au seuil de signification α ...

  12. Calibration of Load Duration Factor kmod

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Stang, Birgitte Friis Dela; Svensson, Staffan

    and the stochastic models are formulated in accordance with the load models in the Danish structural codes, DS 409, and DS 410. three damage accumulation models are considered, namely Gerhards model, Barret & Foschi's model, and Foschi & Yao's model. The parameters in these moels are fitted using data relevant...

  13. Gestion des forêts domaniales en période de conflits : cas de la forêt ...

    African Journals Online (AJOL)

    Gestion des forêts domaniales en période de conflits : cas de la forêt classée du Haut-Sassandra, Centre-Ouest de la Côte d'Ivoire. Akoua Tamia Madeleine Kouakou, Yao Sadaiou Sabas Barima, Souleymane Konate, Issouf Bamba, Justin Yatty Kouadio, Jan Bogaert ...

  14. Author Details

    African Journals Online (AJOL)

    Yao, M. K.. Vol 9, No 7S (2017) - Articles Aesthetic and semanticaccents of the neo-gothic interpretation in Russia Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  15. Symplocaceae

    African Journals Online (AJOL)

    There are only few reports on the chemical composition of ... However, literature searches have shown no report on ..... Jiang J, Feng Z, Wang Y, Zhang P. New phenolics from the roots of ... Song J, Li N, Xia Y, Gao Z, Zou SF, Kong L, Yao YJ, Jiao. YN, Yan YH ... Han YH, Kee JY, Park J, Kim HL, Jeong MY, Kim DS,. Jeon YD ...

  16. GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS ...

    African Journals Online (AJOL)

    Pavel M.E., Baum U., Hahn E.G., Hensen J. Doxorubucin and streptozocin after failed biotherapy of Neuroendocrine tumors. Int J. Gastrointest Cancer 2005; 35 179-185. 33. Yao J.C., Phan A., Hoff P.M., et al. Targeting vas- cular endothelial growth factor in advanced carci- noid tumors: a random assignment phase II study.

  17. Recursion Versus Replication in Simple Cryptographic Protocols

    DEFF Research Database (Denmark)

    Hüttel, Hans; Srba, Jiri

    2005-01-01

    We use some very recent techniques from process algebra to draw interesting conclusions about the well studied class of ping-pong protocols introduced by Dolev and Yao. In particular we show that all nontrivial properties, including reachability and equivalence checking wrt. the whole van Glabbee...

  18. chronic dehydration affects hydroelectrolytic equilibrium and adrenal

    African Journals Online (AJOL)

    A. Dekar-Madoui

    2017-05-01

    May 1, 2017 ... response but rather an index of metabolic strategy probably for metabolic ... [11] Dai WJ, Yao T. Effects of dehydration and salt-loading on ... [12] Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of.

  19. Jiecai Han

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Jiecai Han. Articles written in Bulletin of Materials Science. Volume 25 Issue 4 August 2002 pp 263-266 Synthesis. Self-propagating high temperature synthesis and magnetic properties of Ni0.35Zn0.65Fe2O4 powders · Yao Li Jiupeng Zhao Jiecai Han · More Details Abstract ...

  20. 'Iktibasi' katika Tenzi za Mwanakupona na Al-Inkishafi | Beja | Kioo ...

    African Journals Online (AJOL)

    Makala haya yanatazama tenzi za kale za Kiswahili kwa mkabala wa kitabu kitukufu cha Kurani na Sunnah za Mtume Muhammad (SAW). Wahakiki wengi wamechambua tenzi hizi za kale na kutoa maoni kwamba zina maudhui ya dini ya Kiislamu. Hata hivyo ushahidi halisi wa jinsi watunzi walivyochota maudhui yao ...

  1. KISWAHILI AU KIINGEREZA? SIASA NA LUGHA MUAFAKA YA ...

    African Journals Online (AJOL)

    Madhumuni ya makala hii ni kuonyesha kuwa wataalam wenye wajibu wa kushughulikia tatizo la utayari wa Kiswahili katika elimu walishamaliza kazi yao zamani na wakabainisha kuwa, kwa Tanzania, Kiswahili kikitumika mara moja katika mfumo mzima wa elimu badala ya Kiingereza au lugha nyingine, mabadiliko ya ...

  2. Genetic and phenotypic parameters of pelt traits in a Karakul control ...

    African Journals Online (AJOL)

    D.Sc.(Agric)-tesis, Univ. van die O.V.S.. VAN NIEKERK, A.1.A., SCHOEMAN, S.1. & NEL, lA., 1968. Oorerflikhede van en genetiese korrelasies tussen Karakoel- pelseienskappe. Hand. S.-Afr. Diereprod. 7, 161. YAO, T.S., SIMMONS, V.L. & SCHOTT, R.G., 1953. Heritablity of fur. ,;haracters and birth weight in Karakul lambs.

  3. Determination of Heavy Metal Ions in Tobacco and Tobacco Additives

    African Journals Online (AJOL)

    NJD

    This paper describes a new method for the simultaneous determination of heavy metal ions in tobacco and tobacco additives by ... The HPLC system consisted of a Waters 2690 Alliance separation ..... 1 Z.H. Shi and C.G. Fu, Talanta, 1997, 44, 593. ... 5 Q.F. Hu, G.Y. Yang, J.Y. Yin and Y. Yao, Talanta, 2002, 57, 751.

  4. Malawian ethnic music: concepts of hand clapping, foot stamping ...

    African Journals Online (AJOL)

    of this music. The songs used in this article are transcribed as heard and perceived from direct participation in singing them in their contexts. They are .... for understanding the concepts of pedagogy and memory aids that serve the. Yao well, for .... to some more general-non-verbal-aspects of the situation in which the words.

  5. Cloning and homologic analysis of Tpn I gene in silkworm Bombyx ...

    African Journals Online (AJOL)

    Cloning and homologic analysis of Tpn I gene in silkworm Bombyx mori. Y Zhao, Yao Q, X Tang, Q Wang, H Yin, Z Hu, J Lu, K Chen. Abstract. The troponin complex is composed of three subunits, Troponin C (the calcium sensor component) and Troponin T and I (structural proteins). Tpn C is encoded by multiple genes in ...

  6. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 127; Issue 9. Three silver (I) supramolecular compounds constructed from pyridinium or methylimidazolium polycations: Synthesis, crystal structure and properties. Yao Li Wen Li Zhang Hai Juan Du Chao-Hai Wang Ya Bin Lu Yun-Yin Niu. Volume 127 Issue 9 ...

  7. A new species of genus Oobius (Hymenoptera: Encyrtidae) from the Russian Far East that parasitizes eggs of Emerald Ash Borer

    Science.gov (United States)

    A new egg parasitoid of the emerald ash borer Agrilus planipennis Fairmaire (Coleoptera: Buprestidae) is described from the Vladivostok, Russia, Oobius primorskyensis Yao & Duan n. sp. Both morphological characters and analysis of DNA sequence divergence suggest that this species is different from t...

  8. Differences in the reproductive biology and diapause of two congeneric species of egg parasitoids (Hymenoptera:Encyrtidae) from northeast Asia: implications for biological control of the invasive emerald ash borer

    Science.gov (United States)

    Oobius primorskyensis Yao and Duan and Oobius agrili Zhang and Huang (Hymenoptera: Encyrtidae) constitute a cryptic species complex of egg parasitoids attacking the emerald ash borer Agrilus planipennis (Coleotpera: Buprestidae) in their native range of northeast Asia. While O. primorskyensis is c...

  9. A new species of oobius trjapitzin (hymenoptera:encyrtidae) from the russian far east that parasitizes eggs of emerald ash borer (coleoptera:buprestidae)

    Science.gov (United States)

    A new egg parasitoid of the emerald ash borer Agrilus planipennis Fairmaire (Coleoptera: Buprestidae) from the Russian Far East, Oobius primorskyensis Yao et Duan is described. Both morphological characters and analysis of DNA sequence divergence suggest that this species is different from the previ...

  10. African Journal of Biotechnology - Vol 14, No 12 (2015)

    African Journals Online (AJOL)

    Effects of temperature, light, desiccation and cold storage on germination of Sophora tonkinensis (Leguminosae) seeds · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. X Pu, YF Huang, CL Pan, L Yao, XR Ai, ZJ Deng, 1015-1019 ...

  11. Aspects of insertion in random trees

    NARCIS (Netherlands)

    Bagchi, Arunabha; Reingold, E.M.

    1982-01-01

    A method formulated by Yao and used by Brown has yielded bounds on the fraction of nodes with specified properties in trees bult by a sequence of random internal nodes in a random tree built by binary search and insertion, and show that in such a tree about bounds better than those now known. We

  12. Medium optimization for protopectinase production by batch culture of

    African Journals Online (AJOL)

    Medium optimization for protopectinase production by batch culture of. C Fan, Z Liu, L Yao. Abstract. Optimization of medium compositions for protopectinase production by Aspergillus terreus in submerged culture was carried out. The medium components having significant effect on protopectinase production were reported ...

  13. Hyperfine Level Interactions of Diamond Nitrogen Vacancy Ensembles Under Transverse Magnetic Fields

    Science.gov (United States)

    2015-10-06

    eigenvalues 0, ±h̄, corresponding to ms = 0,±1 [18]. Figure 1 shows the calculated energy levels as a function of axial field for a fixed transverse...Progress in 5 Physics 77, 056503 (2014). [9] G. Kucsko, P. C. Maurer, N. Y. Yao, M. Kubo , H. J. Noh, P. K. Lo, H. Park, and M. D. Lukin, Nature 500

  14. A novel missense mutation in collagenous domain of EDA gene in a ...

    Indian Academy of Sciences (India)

    Supplementary data: A novel missense mutation in collagenous domain of EDA gene in a. Chinese family with X-linked hypohidrotic ectodermal dysplasia. Daxu Li, Ran Xu, Fumeng Huang, Biyuan Wang, Yu Tao, Zijian Jiang, Hairui Li, Jianfeng Yao,. Peng Xu, Xiaokang Wu, Le Ren, Rui Zhang, John R. Kelsoe and Jie Ma.

  15. Determination of Chemical Constituents of the Marine Pulmonate ...

    African Journals Online (AJOL)

    Determination of Chemical Constituents of the Marine Pulmonate Slug, Paraoncidium reevesii. B Sun, H Shen, H Wu, L Yao, Z Cheng, Y Diao. Abstract. Purpose: To isolate and identify the chemical components of Paraoncidium reevesii. Methods: Silica gel column chromatography was used to isolate the components from ...

  16. Genetic diversity based on SSR markers in maize (Zea mays L.)

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 87; Issue 3. Genetic diversity based on SSR markers in maize (Zea mays L.) landraces from Wuling mountain region in China. Yao Qi-Lun Fang Ping Kang Ke-Cheng Pan Guang-Tang. Research Note Volume 87 Issue 3 December 2008 pp 287-291 ...

  17. Evaluation of essential oil composition and DNA diversity of mint ...

    African Journals Online (AJOL)

    use

    2011-11-23

    Nov 23, 2011 ... Full Length Research Paper. Evaluation of essential oil composition and DNA diversity of mint resources from China. Chen Xiao Hua, G. R. Wang and Yao Lei*. Aromatic Plant R&D Centre, School of Agriculture and Biology, Shanghai Jiao Tong University Shanghai 200240, China. Accepted 19 September ...

  18. 專論/台灣圖書館史數位圖書館建構之研究/王梅玲;蔡明月;陳志銘;柯雲娥;蔡佳縈;陳勇汀;林怡甄 | A Digital Library Pilot Study on Taiwan Libraries' History / Mei-Ling Wang; Ming-Yueh Tsay; Chih-Ming Chen; Yun-Er Ke; Chia-Ying Tsai; Yong-Ting Chen; Yi-Jen Lin

    Directory of Open Access Journals (Sweden)

    王梅玲、蔡明月、陳志銘、柯雲娥、蔡佳縈、陳勇汀、林怡甄

    2008-04-01

    Full Text Available

    圖書館是保存與詮釋人類文化重要的機構,1990 年代開始,網際網路的進步,促成數位圖書館蓬勃發展,有人預測它就是未來的圖書館,因此,圖書館界與教育界積極參與相關研究。台灣地區歷經日據時期、重建 時期、成長時期及茁壯時期四階段,建設許多圖書館,有其豐富的主題與素材值得發展成為數位圖書館。政治大學圖書資訊與檔案學研究所有鑑於此,提出「『台灣 百無圖書館史』數位圖書館」的構想,並獲得政大「發展國際一流大學及頂尖研究中心計畫」經費支持。本研究計畫目的包括:(1探索以台彎圖書館事業史為主 題的數位圖書館建構模式;(2建構數位圖書館以支援圖書資訊學教育與研究;(3研訂圖書館事業史料文獻的Metadata與數位資料格式;(4將圖 書文獻與文物數位化以建構數位館藏;(5發展數位圖書館系統與技術;(6研發數位圖書館網站的瀏覽與檢索功能;(7探討數位圖書館支援數位學習的模 式。計畫成果共研訂六種 Metadata標準:建置746筆數位化資料;以Dspace系統平台,依據需求設計台灣百年圖書館史系統架構與網站,最後提出結論與建議。

    Libraries are important social institutions that preserve and communicate human culture and knowledge. From the beginning of 1990s, the digital library has grown up rapidly based on the progress of the Internet. Libraries and educational institutions should be actively involved in digital library research and development. The Taiwan libraries’ history can be divided into four stages: Japanese occupation period, reconstruction period, growth period and strong period. In these processes, many events and libraries with rich materials that can be developed into a digital library. Graduate Institute of Library, Information and Archival Studies, National Chengchi University, planned the Digital Library Pilot Study on Taiwan Libraries’ History and got the university support. The pilot study objectives include: (1 exploring the digital library model on Taiwan libraries' history; (2 constructing digital library to support education and research in information and library science; (3 developing Metadata standards of library documents and heritage; (4 digitalizing documents and heritage to build digital collections (5 developing digital library systems and technology; (6 researching browsing and search functions of the digital library; (7 exploring the model of the digital library supports e-learning. In this pilot study, we developed six Metadata standards, built 746 digital resources, constructed a digital library system and web site, and proposed the conclusions and suggestions finally.

    頁次:15-38

  19. The study is believed to be used to treat illnesses Yau ceremony of Phutai. Natal village , Tambon Tao Ngoi, Tao Ngoi District, Sakon Nakhon Province

    Directory of Open Access Journals (Sweden)

    Boonchom Srisa-ard

    2016-12-01

    Full Text Available This research aimed to 1 study the beliefs and the cause of the ailments of the ceremony to Yau. Which is from Thailand, Village Natal district, Tao Ngoi District, Sakon Nakhon 2 to study the composition of the ceremony Yao and 3 to study the Yau ceremony. The method resources from data collection divided into two parts, there were 1 documentation research articles, theses, books, textbooks and information from the Internet, and 2 the interview with the people who knew the four ceremonies of You. The study found the phenomenon as follows: 1 Belief in the Yau ceremony, that Yau is believed to cure illness, disease caused by an act of the devil. The treatment with modern medicine can not be cured. Parents or family elders had prior therapy with Yau. The disease which is believed to occur in this manner must be gone because of Yao. Some of which can actually be cured, mean while some extended for several more years. The treatment facilities for patients is that Yao can be come home. And pitched immediate treatment faster than the health center or hospital where the procedure was hospitalized several timeconsuming steps. 2 The components of Yau ceremony, are Yau illnesses, Yau is patient, the Yao spit, and music instruments. 3 The ceremony of Yau has five phases: preparation before starting the ceremony. Next, the invitation to the major deities or spirits. then Yao toss the cause of the illness. the reassure patients to leave the various deities and spirits. leave the body return to and live in their residence.

  20. 'It was caused by the carelessness of the parents': cultural models of child malnutrition in southern Malawi.

    Science.gov (United States)

    Flax, Valerie L

    2015-01-01

    Parents' conceptions of child growth, health and malnutrition are culturally bound, making information about local understandings of malnutrition and its causes necessary for designing effective nutrition programmes. This study used ethnographic methods to elucidate cultural models of child care and malnutrition among the Yao of southern Malawi. Data were collected in six rural villages from 28 key informant interviews with village chiefs and traditional healers among others and 18 focus group discussions with parents and grandmothers of young children. For the Yao, lack of parental care is a key cause of poor child health and can lead to thinness (kunyililika) or swelling (kuimbangana). Parents are said to be careless if they are not attentive to the child's needs, are unable to provide adequate quality or quantity of food, or fail to follow sexual abstinence rules. Maintaining abstinence protects the family and failure to do so causes the transfer of 'heat' from a sexually active parent to a 'cold' child and results in child health problems, including signs and symptoms of malnutrition. These findings indicate that the Yao understanding of care is much broader than the concept of care during feeding described in the nutrition literature. In addition, the Yao note the importance of several key feeding practices supported by international agencies and understand the influence of illness on child nutritional status. These congruencies with the public health frame should be used together with information about the cultural context to design more socially and emotionally relevant care and nutrition programmes among the Yao. © 2013 John Wiley & Sons Ltd.

  1. Ethnic Variations in Pterygium in a Rural Population in Southwestern China: The Yunnan Minority Eye Studies.

    Science.gov (United States)

    Zhong, Hua; Chen, Qin; Li, Jun; Shen, Wei; Sheng, Xun; Niu, Zhiqiang; Zhou, Hua; Wei, Tao; Yuan, Yuansheng; Pan, Chen-Wei

    2016-01-01

    To determine the prevalence and associations of pterygium in a multiethnic adult population in rural China and to examine potential ethnic differences Methods: A total of 6418 adults (2133 ethnic Bai, 2130 ethnic Yi, and 2155 ethnic Han) aged 50 years or older participated in the study. Anterior segment examination was performed without pupil dilation using a slit lamp. Pterygium was defined as a raised fleshy triangular fibrovascular tissue growth of the conjunctiva encroaching onto a clear cornea. Pterygium was least prevalent among adults of Yi ethnicity (29.5%) compared with Bai (39.0%, p ethnicities. Those of Bai ethnicity were most likely to be affected by severe pterygium (7.5%), while Yi were least likely to be affected (3.8%). Multivariate analysis revealed that increasing age (odds ratio, OR, 1.017), female sex (OR 1.53), lower educational level (OR 1.25), higher blood pressure levels (OR 1.002), and greater time spent outdoors per day (OR 1.09) were significantly associated with a higher prevalence of pterygium, while Yi ethnicity (OR 0.65, comparing Yi with Han) and wearing brimmed hats outdoors (OR 0.82) were protective factors. Ethnicity was significantly associated with prevalence of pterygium. Our findings may be applicable to many other countries located within the "pterygium belt" for health resource allocation among different ethnic groups.

  2. Meaningful use of peak particle velocities at excavation surfaces for the optimisation of the rockburst criteria for tunnels and stopes

    CSIR Research Space (South Africa)

    Cichowicz, A

    2001-03-01

    Full Text Available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

  3. The Effect of Gamma Irradiation on Yellowness Index (Y I) and Mechanical Properties in Plastic Food Packaging

    International Nuclear Information System (INIS)

    Tanhindarto, Rindy P.; I, Dian

    2002-01-01

    An experiment has been done for measuring the yellowness index (Yi) and mechanical properties at food packaging material was caused by gamma irradiation. The samples were obtained from the manufacture. There were three of samples with types of poly acrylonitrile copolymer, PVdC laminated biaxially oriented polypropylene and poly vinyl chloride films. Samples were irradiated at ambient temperature by gamma rays with the doses of 0 up to 100 kGy. Yellowness Index (Yi) of sample was carried out by using chromameter Hunter Lab system. while mechanical properties measuring by stragraph. The purpose of the present experiment was the yellowness index (Yi) and mechanical properties of food packaging material after and before the irradiation. The effects of I year storage on irradiated and unirradiated samples were also investigated. The results showed that best of three samples of plastic food packaging was poly acrylonitrile copolymer film because the Yellowness Index (Yi) and mechanical properties of poly acrylonitrile copolymer did not give any measurable change on the plastic treated by irradiation up to 100 kGy. Storage for 1 year gave some measurable changes of e Yellowness Index (Yi) and mechanical properties on all the samples examined

  4. Evaluation of drought tolerance and yield capacity of barley (hordeum vulgare) genotypes under irrigated and water-stressed conditions

    International Nuclear Information System (INIS)

    Khokhar, M.I.; Silva, J.A.T.D

    2012-01-01

    Twelve barley genotypes developed through different selection methods were evaluated under drought and irrigated conditions. The results of a correlation matrix revealed highly significant associations between Grain Yield (Yp) and Mean Productivity (MP), Stress Tolerance Index (STI), Geometric Mean Productivity (GMP) and Yield Index (Yi) under irrigated conditions while the Mean Productivity (MP), Yield Stability Index (Yi), Stress Tolerance Index (STI), Geometric Mean Productivity (GMP) and Yield Index (Yi) had a high response under stressed condition. Based on a principal component analysis, Geometric Mean Productivity (GMP), Mean Productivity (MP) and Stress Tolerance Index (STI) were considered to be the best parameters for selection of drought-tolerant genotypes. The 2-row barley genotypes B-07023 and B-07021 performed better in yield response under drought conditions and were more stable under stress conditions. Furthermore, drought stress reduced the yield of some genotypes while others were tolerant to drought, suggesting genetic variability in this material for drought tolerance. (author)

  5. Optimal spatial sampling scheme to characterize mine tailings

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2009-08-01

    Full Text Available , the location and the covariates as external drift were used to estimate the heavy metal concentration, E[Z(x)] = b 0 + b1 · xu + b2 · xv + b3 ·GOE(x) + b4 · JAR(x) + b5 · FER(x) + b6 ·HEM(x) (8) +b 7 ·KAO(x) + b8 · COP(x) , S TC P M s S es si on s namely, a first... (4) E[Z(x)] = b 0 + ∑ bi · yi(x) = ∑ bi · yi(x) , i=1 i=0 where y0(x) = 1. The method of merging both sources of information uses {yi(x)} as an external drift function for the estimation of Z(x). The drift of Z(x) is defined externally through...

  6. Work environment impact scale: testing the psychometric properties of the Swedish version.

    Science.gov (United States)

    Ekbladh, Elin; Fan, Chia-Wei; Sandqvist, Jan; Hemmingsson, Helena; Taylor, Renée

    2014-01-01

    The Work Environment Impact Scale (WEIS) is an assessment that focuses on the fit between a person and his or her work environment. It is based on Kielhofner's Model of Human Occupation and designed to gather information on how clients experience their work environment. The aim of this study was to examine the psychometric properties of the Swedish version of the WEIS assessment instrument. In total, 95 ratings on the 17-item WEIS were obtained from a sample of clients with experience of sick leave due to different medical conditions. Rasch analysis was used to analyze the data. Overall, the WEIS items together cohered to form a single construct of increasingly challenging work environmental factors. The hierarchical ordering of the items along the continuum followed a logical and expected pattern, and the participants were validly measured by the scale. The three occupational therapists serving as raters validly used the scale, but demonstrated a relatively high rater separation index, indicating differences in rater severity. The findings provide evidence that the Swedish version of the WEIS is a psychometrically sound assessment across diagnoses and occupations, which can provide valuable information about experiences of work environment challenges.

  7. TRAF4 and Castration-Resistant Prostate Cancer

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-15-1-0536 TITLE: TRAF4 and Castration-Resistant Prostate Cancer PRINCIPAL INVESTIGATOR: Ping Yi CONTRACTING...Castration Resistant prostate cancer 5b. GRANT NUMBER W81XWH-15-1-0536 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Ping Yi 5d. PROJECT NUMBER 5e. TASK...to be a critical player in castration-resistant prostate cancers . It was suggested that the function of AR in CRPC is not to turn on the same

  8. Two Enhancements of the Logarithmic Least-Squares Method for Analyzing Subjective Comparisons

    Science.gov (United States)

    1989-03-25

    error term. 1 For this model, the total sum of squares ( SSTO ), defined as n 2 SSTO = E (yi y) i=1 can be partitioned into error and regression sums...of the regression line around the mean value. Mathematically, for the model given by equation A.4, SSTO = SSE + SSR (A.6) A-4 where SSTO is the total...sum of squares (i.e., the variance of the yi’s), SSE is error sum of squares, and SSR is the regression sum of squares. SSTO , SSE, and SSR are given

  9. The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia

    Science.gov (United States)

    2017-03-01

    AWARD NUMBER: W81XWH-16-1-0055 TITLE: The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia PRINCIPAL INVESTIGATOR: Yi...Immune-Mediated Aplastic Anemia 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0055 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Yi Zhang 5d... anemia (AA) is a condition of bone marrow failure (BMF) characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated

  10. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy

    DEFF Research Database (Denmark)

    Barsberg, Søren Talbro; Lee, Y.-I.; Rasmussen, Hanne Nina

    2018-01-01

    Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344......Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344...

  11. 清末民初における『レ・ミゼラブル』の移入と日本 : 陳景韓訳「哀史之一節逸犯」を例として

    OpenAIRE

    梁, 艶; Liang, Yan

    2011-01-01

    Victor Hugo was introduced into China through his Japanese translations. However, the route of the reception of his masterpiece Les Misérables in China has not yet been explained clearly. In this paper, I will take Ai Shi Zhi Yi Jie Yi Fan, a Chinese translation by Chen Jinghan of a part of Les Misérables, as an example to see how Les Misérables was introduced into China. By examining Japanese translations of Les Misérables, I come to the conclusion that Chen was influenced by Kuroiwa Ruikô's...

  12. Generalized reciprocity principle for discrete symplectic systems

    Directory of Open Access Journals (Sweden)

    Julia Elyseeva

    2015-12-01

    Full Text Available This paper studies transformations for conjoined bases of symplectic difference systems $Y_{i+1}=\\mathcal S_{i}Y_{i}$ with the symplectic coefficient matrices $\\mathcal S_i.$ For an arbitrary symplectic transformation matrix $P_{i}$ we formulate most general sufficient conditions for $\\mathcal S_{i},\\, P_{i}$ which guarantee that $P_{i}$ preserves oscillatory properties of conjoined bases $Y_{i}.$ We present examples which show that our new results extend the applicability of the discrete transformation theory.

  13. Bottle appeal drifts across the Pacific

    Science.gov (United States)

    Ebbesmeyer, Curtis; Ingraham, W. James, Jr.; McKinnon, Richard; Okubo, Akira; Wang, Dong-Ping; Strickland, Richard; Willing, Peter

    Pacific drift currents were used by a group of oceanographers to estimate the path of a drift bottle that was found on a beach of Barkley Sound in Vancouver Island by Richard Strickland on June 10, 1990. The Chinese rice wine bottle, which remained unopened until December 18, 1991, contained six leaflets, one appealing for the release of China's well-known dissident, Wei Jingsheng. The bottle was one of thousands set adrift as part of a propaganda effort from the islands of Quemoy and Matsu off mainland China shortly after Wei was sentenced in 1979 to 15 years in prison (see Figure 1 for locations). Wei was in poor health and still in prison when the bottle made its way across the Pacific Ocean.

  14. Mathematisches Bewusstsein

    Science.gov (United States)

    Kaenders, Rainer; Kvasz, Ladislav

    Wenn jemand sagt, dass ein Bus um 9 Uhr abfährt - weiß man es dann? Angenommen, man ist darüber unterrichtet, dass die Busse unter der Woche immer zur vollen Stunde abfahren - von 7 Uhr morgens bis 7 Uhr abends, weiß man es dann mit dem Wissen um diese allgemeine Regel besser, dass der Bus um 9 Uhr abfährt? Macht es einen Unterschied, ob man den Fahrplan erstellt, den Bus lenkt oder nur mitfährt, um sich dieser Tatsache bewusst zu sein?

  15. Graphene energy storage and conversion applications

    CERN Document Server

    Liu, Zhaoping

    2014-01-01

    Series PrefacePrefaceAuthorsGraphene Overview; Xufeng Zhou, Wei Wang, and Zhaoping LiuSynthesis of Graphene; Wei Wang, Hailiang Cao, Xufeng Zhou, and Zhaoping LiuApplications of Graphene in Lithium Ion Batteries; Xufeng Zhou and Zhaoping LiuApplications of Graphene in New-Concept Batteries; Xufeng Zhou and Zhaoping LiuApplications of Graphene in Supercapacitors; Chao Zheng, Xufeng Zhou, Hailiang Cao, and Zhaoping LiuApplications of Graphene in Solar Cells; Fuqiang Huang, Dongyun Wan, Hui Bi, and Tianquan LinApplications of Graphene in Fuel Cells; Xuejun Zhou, Jinli Qiao, and Yuyu LiuIndex.

  16. Appendix to Power Dissipation in Division

    DEFF Research Database (Denmark)

    Liu, Wei; Nannarelli, Alberto

    This document is an appendix to the paper: Wei Liu and Alberto Nannarelli, ”Power Dissipation in Division”, Proc. of 42nd Asilomar Conference on Signals, Systems, and Computers, October 2008. The purpose of the document is to provide the necessary information for the implementation of the archite......This document is an appendix to the paper: Wei Liu and Alberto Nannarelli, ”Power Dissipation in Division”, Proc. of 42nd Asilomar Conference on Signals, Systems, and Computers, October 2008. The purpose of the document is to provide the necessary information for the implementation...

  17. Study of provenance properties on ancient celadon of different kilns with NAA

    International Nuclear Information System (INIS)

    Feng Songlin; Fan Dongyu; Feng Xiangqian; Xu Qing; Cheng Lin; Lei Yong; Shen Yueming; Zhang Wenjiang; Zhua Zhenxi

    2005-01-01

    Provenance characteristic is an important scientific parameter to identify ancient porcelain wares unearthed from sites and graves. The porcelain samples of Si-Long-Kou Yue kiln of Zhejiang Province, Hong-Zhou kiln of Jiangxi Province and Yao-Zhou kiln of Shanxi Province have been analyzed with neutron activation analysis (NAA). The experimental data were studied with statistic methods. The results show that the chemical compositions of porcelain body samples for three kilns were different. The difference was able to be identified. The body materials of both Si-Long-Kou Yue kiln and Hong-Zhou kiln of Jiangxi were similar. The samples of Yao-Zhou kiln in north of China existed obvious difference. (authors)

  18. MiniLEGO

    DEFF Research Database (Denmark)

    Frederiksen, Tore Kasper; Jakobsen, Thomas Pelle; Nielsen, Jesper Buus

    2013-01-01

    One of the main tools to construct secure two-party computation protocols are Yao garbled circuits. Using the cut-and-choose technique, one can get reasonably efficient Yao-based protocols with security against malicious adversaries. At TCC 2009, Nielsen and Orlandi [28] suggested to apply cut......-and-choose at the gate level, while previously cut-and-choose was applied on the circuit as a whole. This idea allows for a speed up with practical significance (in the order of the logarithm of the size of the circuit) and has become known as the “LEGO” construction. Unfortunately the construction in [28] is based...... on a specific number-theoretic assumption and requires public-key operations per gate of the circuit. The main technical contribution of this work is a new XOR-homomorphic commitment scheme based on oblivious transfer, that we use to cope with the problem of connecting the gates in the LEGO construction. Our...

  19. 2691-IJBCS-Article-Rachel A Koum

    African Journals Online (AJOL)

    hp

    http://indexmedicus.afro.who.int. Evaluation de la compétitivité des systèmes piscicoles pratiqués en Côte d'Ivoire: gestion, alimentation et production. Hortense A. YAO1,2, Rachel A. KOUMI2*, Céline Sidonie K. NOBAH3,. Célestin B. ATSE2 et Paul E. KOUAMELAN1. 1UFR Biosciences, Université Félix Houphouët-Boigny, ...

  20. Genetic analysis of fertility restoration genes for WA- type ...

    African Journals Online (AJOL)

    Yomi

    gtg tcg ccg gtc aag aac. 55. RM7003. 12 ggc aga cat aca gct tat agc tgc aaa tga acc cct cta gc. 55 at a distance of 1.9 cm from each. Using RAPD and. RFLP markers, Yao et al. (1997) confirmed the location of Rf3 on chromosome 1 and mapped the second Rf locus (Rf4) on chromosome 10 at 3.3 cm from G4003. Jing et al.

  1. Effects of Simultaneous Radiofrequency Radiation and Chemical Exposure of Mammalian Cells. Volume 2

    Science.gov (United States)

    1988-07-01

    chromosome - - - - - - -I aberrations and sister chromatid exchanges (SCE). Yao (1982) exposed rat kangaroo RH5 and RH1l6 cells to 2.45 GHz radiation, and...control was reported in chromosome aberrations. Yac (1982) investigated the cytogenetic consequences of chronic microwave exposure on rat kangaroo RH5...was said to be 280C. The cells were exposed both as conidia, which are "rather inactive metabolically ," and also after DNA replication had been

  2. Recursion vs. Replication in Simple Cryptographic Protocols

    DEFF Research Database (Denmark)

    Huttel, Hans; Srba, Jiri

    2005-01-01

    We use some recent techniques from process algebra to draw several conclusions about the well studied class of ping-pong protocols introduced by Dolev and Yao. In particular we show that all nontrivial properties, including reachability and equivalence checking wrt. the whole van Glabbeek's spect...... of messages in the sense of Amadio, Lugiez and Vanackere. We conclude by showing that reachability analysis for a replicative variant of the protocol becomes decidable....

  3. Algorithms for classical and modern scheduling problems

    OpenAIRE

    Ott, Sebastian

    2016-01-01

    Subject of this thesis is the design and the analysis of algorithms for scheduling problems. In the first part, we focus on energy-efficient scheduling, where one seeks to minimize the energy needed for processing certain jobs via dynamic adjustments of the processing speed (speed scaling). We consider variations and extensions of the standard model introduced by Yao, Demers, and Shenker in 1995 [79], including the addition of a sleep state, the avoidance of preemption, and variable speed lim...

  4. Taxonomic studies of Glochidion (Phyllanthaceae) from the Indo-China Peninsula (I): G. shanense, a new species from Myanmar

    Science.gov (United States)

    Yao, Gang; Cai, Jie; Wu, Youheng; Yang, Xuefei; Oo, Thaung Naing; Moe, Aung Zaw; Luo, Shixiao

    2018-01-01

    Abstract Based on morphological studies performed on live plants in the field and specimens deposited in herbaria, a new species, Glochidion shanense Gang Yao & Shixiao Luo (Phyllantheae, Phyllanthaceae), is here described and illustrated. The species is morphologically most similar to G. ellipticum Wight, but can be distinguished from the latter by having hairy branchlets, longer pedicels, uniseriate and narrowly triangular sepals of female flowers, 4–5-locular ovaries, stout and cylindric persistent style on fruits. PMID:29670453

  5. Anti-CD30-targeted gold nanoparticles for photothermal therapy of L-428 Hodgkin’s cell [Erratum

    Directory of Open Access Journals (Sweden)

    Qu X

    2013-04-01

    Full Text Available ErratumQu X, Yao C, Wang J, Li Z, Zhang Z. International Journal of Nanomedicine. 2012;7:6095–6103. The caption for Figure 4 was incorrect in the published paper. The correct Figure 4 caption is as follows:Figure 4 Photothermal treatments of L-428 cells with gold-BerH2 conjugates. (A Without laser irradiation; (B with 532 nm laser irradiation with 50 mW, 5 pulses.Read the original article

  6. Simulations of Quantum Turing Machines by Quantum Multi-Stack Machines

    OpenAIRE

    Qiu, Daowen

    2005-01-01

    As was well known, in classical computation, Turing machines, circuits, multi-stack machines, and multi-counter machines are equivalent, that is, they can simulate each other in polynomial time. In quantum computation, Yao [11] first proved that for any quantum Turing machines $M$, there exists quantum Boolean circuit $(n,t)$-simulating $M$, where $n$ denotes the length of input strings, and $t$ is the number of move steps before machine stopping. However, the simulations of quantum Turing ma...

  7. Strategic Insights. Volume 10, Issue 1, Spring 2011

    Science.gov (United States)

    2011-01-01

    weapons in our arsenal and ban chemical and biological weapons. With persistence, there are solutions. A way around the attribution problem may be to...metal and plastic . America needs the ability to carpet bomb in cyberspace to create the deterrent we lack.13 In other words, Williamson was not only...Insights • Spring 2011 Volume 10, Issue 1 25 Cyber Conflict Between Taiwan and China Yao-chung Chang Introduction The Republic of China ( Taiwan

  8. Covariance of random stock prices in the Stochastic Dividend Discount Model

    OpenAIRE

    Agosto, Arianna; Mainini, Alessandra; Moretto, Enrico

    2016-01-01

    Dividend discount models have been developed in a deterministic setting. Some authors (Hurley and Johnson, 1994 and 1998; Yao, 1997) have introduced randomness in terms of stochastic growth rates, delivering closed-form expressions for the expected value of stock prices. This paper extends such previous results by determining a formula for the covariance between random stock prices when the dividends' rates of growth are correlated. The formula is eventually applied to real market data.

  9. : Their role in choice of major and success at university

    OpenAIRE

    Nagy, Gabriel

    2010-01-01

    Student interests and abilities are crucial to career-related transitions (Swanson & Fouad, 1999): they are key determinants of individual choices (Humphreys & Yao, 2002), and the fit between abilities and demands as well as interest congruence (i.e., the fit between individual interests and environmental opportunities) contribute to the success of the career paths chosen (Lubinski & Benbow, 2000). The aim of the present research was to investigate the role of vocational interests (based ...

  10. A molecular doorstop ensures a trickle through translational repression.

    Science.gov (United States)

    Brook, Matthew; Smith, Richard W P; Gray, Nicola K

    2012-03-30

    Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event. Copyright © 2012 Elsevier Inc. All rights reserved.

  11. 2690-IJBCS-Article-N'goran David Vincent K

    African Journals Online (AJOL)

    hp

    régime fourrager supplémenté par la farine de poisson et/ou du maïs-grain durant le cycle de reproduction. N'Goran David Vincent KOUAKOU* et Yao Brice Savier BROU. Département de Formation et de Recherche Agriculture et Ressources animales, Institut National. Polytechnique Félix Houphouët-Boigny, B.P. 1313 ...

  12. Palynologie et environnements de dépôt des sédiments d'âge ...

    African Journals Online (AJOL)

    Sédimentologie, biostrati- graphie.Thèse de Doctorat, univ.Pau, 366p. Digbehi Z. B ; Yao K. R ; Tea Y. Y. & Boblai G., 1996. Contribution à l'étude palynologique et environnementale du Campanien et du. Maastrichtien du bassin offshore de Côte d'Ivoire. Géologie Méditerranéenne, tome XXIII, n°2, 1996, pp. 155-171.

  13. Confidence Matters

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    China’s economy passed over a bumpy road last year. Influenced by the global economic crisis, China faces many uncertainties in 2009. Yao Jingyuan, Chief Economist of the National Bureau of Statistics, gave a speech at the 2009 China Mining Merger and Acquisition Forum at Tsinghua University on January 10 about the risks the country faces and the positive factors that still exist in China’s economic development. Excerpts follow.

  14. A Filtering Method to Reveal Crystalline Patterns from Atom Probe Microscopy Desorption Maps

    Science.gov (United States)

    2016-03-26

    reveal crystalline patterns from atom probe microscopy desorption maps Lan Yao Department of Materials Science and Engineering, University of Michigan, Ann...reveal the crystallographic information present in Atom Probe Microscopy (APM) data is presented. Themethod filters atoms based on the time difference...between their evaporation and the evaporation of the previous atom . Since this time difference correlates with the location and the local structure of

  15. Competitive Analysis for Online Leasing Problem with Compound Interest Rate

    OpenAIRE

    Yang, Xingyu; Zhang, Weiguo; Xu, Weijun; Zhang, Yong

    2011-01-01

    We introduce the compound interest rate into the continuous version of the online leasing problem and discuss the generalized model by competitive analysis. On the one hand, the optimal deterministic strategy and its competitive ratio are obtained; on the other hand, a nearly optimal randomized strategy is constructed and a lower bound for the randomized competitive ratios is proved by Yao's principle. With the help of numerical examples, the theoretical results show that the interest rate pu...

  16. Post-synthetic transformation of a Zn(ii) polyhedral coordination network into a new supramolecular isomer of HKUST-1.

    Science.gov (United States)

    Chen, Yao; Wojtas, Lukasz; Ma, Shengqian; Zaworotko, Michael J; Zhang, Zhenjie

    2017-08-03

    A Zn-based porphyrin containing metal-organic material (porphMOM-1) was transformed into a novel Cu-based porphyrin-encapsulating metal-organic material (porph@HKUST-1-β) via a one-pot post-synthetic modification (PSM) process involving both metal ion exchange and linker installation of trimesic acid. HKUST-1-β is the first example of yao topology and is to our knowledge the first supramolecular isomer of the archetypal coordination network HKUST-1.

  17. Coherent Control of Diamond Defects for Quantum Information Science and Quantum Sensing

    Science.gov (United States)

    2014-04-18

    information of G. Kucsko⇤, P. C. Maurer⇤, N. Yao, M. Kubo , H. J. Noh, P. Lo, H. Park, M. D. Lukin, Nanometer scale thermometry in a living cell, Nature 500, 54...appreciation goes to Minako Kubo , Prof. Peggy Lo and Prof. Hongkun Park from the chemistry department at Harvard for preparing biological sample...initio calculations [40]. From such calculations one finds that the lowest lying energy level is located within the valence band of diamond and the

  18. Submicron Structures and Various Technology

    Science.gov (United States)

    1990-06-01

    Submitted by Professor Jonathan Allen Professor Daniel Kleppner !1! Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge, MA...Alberto Moel, Joyce E. Palmer, Samuel L. Park, Hui Meng Quek , John H.F. Scott-Thomas, Ghavam Shahidi, Siang-Chun The, Anthony Yen Undergraduate...substrates; and Kathleen Early, Reza A. Ghanbari, Yao-Ching Ku, periodic structures for x-ray optics, spectros- Alberto Moel, Hui Meng Quek , Dr. Mark L

  19. Comparison of Automated and Manual Recording of Brief Episodes of Intracranial Hypertension and Cerebral Hypoperfusion and Their Association with Outcome After Severe Traumatic Brain Injury

    Science.gov (United States)

    2017-03-01

    which could limit our ability to evaluate the difference between EVD ICP and IPM ICP. Second, due to the complexity of the human brain and our...quartile 24.8 years and third quartile 49.3 years. There were 68 males and 13 females in this study group. In terms of the severity, those patients...Hypoperfusion and Their Association with Outcome After Severe Traumatic Brain Injury Peter Hu, PhD; Yao Li, MS; Shiming Yang, PhD; Catriona

  20. Transcriptional Regulation by KLF6, A Novel Tumor Suppressor Gene in Prostate Cancer, Through Interaction with HATS and HDACS

    Science.gov (United States)

    2006-03-01

    Kimmelman1, Rui F Qiao1, Goutham Narla2, Asoka Banno1, Nelson Lau3, Paula D Bos1, Nelson Nuñez Rodriguez1, Bertrand C Liang4, Abhijit Guha3, John A...Shen Yao, 1 Asoka Banno, 3 Eldad Hod, 1 Helen L. Reeves, 1 Rui F. Qiao, 3 Olga Camacho-Vanegas, 2 Alice Levine, 1 Alexander Kirschenbaum, 1,4 Andrew M

  1. On some winning strategies for the Iterated Prisoner's Dilemma or Mr. Nice Guy and the Cosa Nostra

    OpenAIRE

    Slany, Wolfgang; Kienreich, Wolfgang

    2006-01-01

    We submitted two kinds of strategies to the iterated prisoner's dilemma (IPD) competitions organized by Graham Kendall, Paul Darwen and Xin Yao in 2004 and 2005. Our strategies performed exceedingly well in both years. One type is an intelligent and optimistic enhanced version of the well known TitForTat strategy which we named OmegaTitForTat. It recognizes common behaviour patterns and detects and recovers from repairable mutual defect deadlock situations, otherwise behaving much like TitFor...

  2. Afrique Science: Revue Internationale des Sciences et Technologie ...

    African Journals Online (AJOL)

    Etude cinétique de la dégradation de l'Endosufane en solution · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Traore, K Mamadou, A Dembele, V Yao, Y Bekro, P Mazellier, B Legube, P Houenou, 362-3771. http://dx.doi.org/10.4314/afsci.v3i3.61620 ...

  3. Etude cinétique de la dégradation de l'Endosufane en solution ...

    African Journals Online (AJOL)

    Etude cinétique de la dégradation de l'Endosufane en solution. S Traore, K Mamadou, A Dembele, V Yao, Y Bekro, P Mazellier, B Legube, P Houenou. Abstract. Les pesticides sont fréquemment utilisés en Côte d'Ivoire. Leur détection dans les eaux de forage témoigne de leur mauvais usage et d'un grave problème ...

  4. Chinese herbal dose in ancient and modern times: a comparative study.

    Science.gov (United States)

    He, Shimin

    2013-04-01

    Appropriate dose guarantees Chinese herb's safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People's Republic of China (2010 Edition) at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria. Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian Jin Yao Fang, a famous ancient literature, have been reviewed and compared with those in the Pharmacopoeia of the People's Republic of China (2010 Edition). The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People's Republic of China (2010 Edition) haven't covered those in Bei Ji Qian Jin Yao Fang. Furthermore, maximal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang. The dose criteria in the Pharmacopoeia of the People's Republic of China (2010 Edition) are not comprehensive enough. Studying ancient literatures is an effective method to gain precious Chinese herbs' dose data and helps for new dose criteria's establishment in the future.

  5. Proceedings of the Korean Radioactive Waste Society Spring 2010

    International Nuclear Information System (INIS)

    2010-01-01

    This proceedings contains articles of the Korean Radioactive Waste Society Spring 2010. It was held on May 13-14, 2010 in Yesan, Korea. The main topics are as follows: Radioactive wastes policy and decontamination and decommissioning, Radioactive waste treatment, Radioactive waste disposal and site selection, Spent fuel and fuel cycle and Radiation safety and environment. (Yi, J. H.)

  6. Proceedings of the Korean Society Nuclear Medicine Spring Meeting 2002

    International Nuclear Information System (INIS)

    2002-01-01

    This proceedings contains articles of 2002 Spring meeting of the Korean Society Nuclear Medicine. It was held on May 17, 2002 in Suwon, Korea. This proceedings is comprised of 3 sessions. The subject titles of session are as follows: Gynecological and Colorectal cancer, Lung cancer and Lymphoma, and general nuclear medicine. (Yi, J. H.)

  7. Evaluation of effectiveness in a novel wound healing ointment ...

    African Journals Online (AJOL)

    Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen ...

  8. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Home; Journals; Journal of Astrophysics and Astronomy; Volume 35; Issue 3. Correlations between Optical Variability and Physical Parameters of Quasars. Wenwen Zuo Xue-Bing Wu Yi-Qing Liu Cheng-Liang Jiao. Part V: Black Holes (or Binary Black Holes) in Blazars Volume 35 Issue 3 September 2014 ...

  9. Effects of Taraxacum mongolicum on in vitro response of milk ...

    African Journals Online (AJOL)

    uwerhiavwe

    2013-03-06

    Mar 6, 2013 ... 4Department of Chinese Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, Taiwan. ... fed a diet with (treatment group, n=7, 150 g TM powder per head per day) ..... g/kg body weight showed no visible signs of acute.

  10. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 120; Issue 1. Issue front cover thumbnail. Volume 120, Issue 1. February 2010, pages 1-130. pp 1-6. On the General Dedekind Sums and its Reciprocity Formula · Yuan Yi · More Details Abstract Fulltext PDF. In this paper, we prove an interesting reciprocity ...

  11. An n-dimensional pseudo-differential operator involving the Hankel ...

    Indian Academy of Sciences (India)

    ji =0 bji x. 2 ji +μ+1/2 i. (x−1 i ∂/∂xi )ri + ji. (x. −μ−1/2 i φ(x1,..., xn)). ⎞. ⎠ ,. (1.8) where the bji are constants depending only on μ. For i = 1, 2,..., n, let (xi , yi , zi ) ...

  12. Southeast Asia Report.

    Science.gov (United States)

    1985-08-06

    the Senegalese ambassador; Fortunäto Isasi Cayo, the Peruvian ambassador; Ana Maria Gonzalez "Suarez, the Cuban ambassador; and Yi Song-Ki, the...who called Da Nang a city of military camps «ere correct, in the entire city there were only two cinemas but there were large houses of Prostitution

  13. Assessment of Group Preferences and Group Uncertainty for Decision Making

    Science.gov (United States)

    1976-06-01

    the individ- uals. decision making , group judgments should be preferred to individual judgments if obtaining group judgments costs more. -26- -YI IV... decision making group . IV. A. 3. Aggregation using conjugate distribution. Arvther procedure for combining indivi(jai probability judgments into a group...statisticized group group decision making group judgment subjective probability Delphi method expected utility nominal group 20. ABSTRACT (Continue on

  14. Optimized Breech Location in the Harry Diamond Laboratories 4-Inch Gas Gun

    Science.gov (United States)

    1982-04-01

    equation can be deduced from the program, it is camouflaged by changes in notation and is repeated here. PAY/ Ma2 = [u-N/(N +1)](1 —u/N)1 + N/(N + 1...AERO-ASTRONAUTICAL ENGINEERING ATTN PROF TING YI LI 2036 NEIL AVENUE COLUMBUS, OH 43210 OCEANICS, INC ATTN DR. PAUL KAPLAN PLAINVIEW LONG ISLAND

  15. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Author Affiliations. J. B. Su1 Z.-Q. Shen1 X. Chen1 Jiyune Yi2 D. R. Jiang1 Y. J. Yun3. Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China. Korea Astronomy and Space Science Institute, Daejeon 305-348, South Korea. Department of Physics and Astronomy, ...

  16. prediction of the impacts of climate changes on the stream flow

    African Journals Online (AJOL)

    HOD

    NNAMDI AZIKIWE UNIVERSITY, AWKA, ANAMBRA STATE, NIGERIA. 3, 4, 5, DEPT. ... 4, October 2017, pp. 1286 – 1295 ..... Cambridge University Press, Cambridge, 1994. ... [10] Park, J. Y., Park M. J., Ahn S. R., Park G. A., Yi,v., Kim. G. S., R.

  17. Hai-Feng Cheng

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Hai-Feng Cheng. Articles written in Bulletin of Materials Science. Volume 37 Issue 1 February 2014 pp 127-132. Investigation of thermoelectric SiC ceramics for energy harvesting applications on supersonic vehicles leading–edges · Xiao-Yi Han Jun Wang Hai-Feng Cheng.

  18. Role of the Neddylation Enzyme Uba3, A New Estrogen Receptor Corepressor in Breast Cancer

    Science.gov (United States)

    2006-09-01

    vs. MCF7) Gene symbol Genbank MCF7-T MCF-F Description Notch signaling pathway PSEN1 NM_007319 1.33 7.06 Presenilin 1 ( Alzheimer disease 3...Medicine Bloomington, Indiana 47405 3Department of Life Science and Institute of Molecular Biology National Chung Cheng University Chia -Yi Taiwan

  19. Anatomical factors predicting lower calyceal stone clearance after ...

    African Journals Online (AJOL)

    M. Khan

    2016-02-17

    Feb 17, 2016 ... Curr Opin Urol 2008;18:214–9. [9] Lingeman JE, Siegal YI, Steele B, Nyhus AW, Woods JR. Manage- ment of lower pole nephrolithiasis: a critical analysis. J Urol 1994;151: 663–7. [10] Sampaio FJB, Aragao AHM. Limitations of extracorporeal shock wave lithotripsy for lower caliceal stone: anatomic insight.

  20. Manganese, iron and copper contents in leaves of maize plants (Zea ...

    African Journals Online (AJOL)

    Yomi

    2012-01-12

    Jan 12, 2012 ... Zn added to the soil and Zn foliar spray at 0.5 weight percent of zinc sulfate) and B (0, ..... In order to determine Fe, Cu and Mn concentrations, leaf ..... Yi Y, Saleeba J, Guerinot ML, Manthey J, Luster D, Crowley DE (1994).