WorldWideScience

Sample records for yale-chile musyc wide

  1. THE MULTIWAVELENGTH SURVEY BY YALE-CHILE (MUSYC): DEEP MEDIUM-BAND OPTICAL IMAGING AND HIGH-QUALITY 32-BAND PHOTOMETRIC REDSHIFTS IN THE ECDF-S

    International Nuclear Information System (INIS)

    Cardamone, Carolin N.; Van Dokkum, Pieter G.; Urry, C. Megan; Brammer, Gabriel; Taniguchi, Yoshi; Gawiser, Eric; Bond, Nicholas; Taylor, Edward; Damen, Maaike; Treister, Ezequiel; Cobb, Bethany E.; Schawinski, Kevin; Lira, Paulina; Murayama, Takashi; Saito, Tomoki; Sumikawa, Kentaro

    2010-01-01

    We present deep optical 18-medium-band photometry from the Subaru telescope over the ∼30' x 30' Extended Chandra Deep Field-South, as part of the Multiwavelength Survey by Yale-Chile (MUSYC). This field has a wealth of ground- and space-based ancillary data, and contains the GOODS-South field and the Hubble Ultra Deep Field. We combine the Subaru imaging with existing UBVRIzJHK and Spitzer IRAC images to create a uniform catalog. Detecting sources in the MUSYC 'BVR' image we find ∼40,000 galaxies with R AB 3.5. For 0.1 < z < 1.2, we find a 1σ scatter in Δz/(1 + z) of 0.007, similar to results obtained with a similar filter set in the COSMOS field. As a demonstration of the data quality, we show that the red sequence and blue cloud can be cleanly identified in rest-frame color-magnitude diagrams at 0.1 < z < 1.2. We find that ∼20% of the red sequence galaxies show evidence of dust emission at longer rest-frame wavelengths. The reduced images, photometric catalog, and photometric redshifts are provided through the public MUSYC Web site.

  2. A PUBLIC, K-SELECTED, OPTICAL-TO-NEAR-INFRARED CATALOG OF THE EXTENDED CHANDRA DEEP FIELD SOUTH (ECDFS) FROM THE MULTIWAVELENGTH SURVEY BY YALE-CHILE (MUSYC)

    International Nuclear Information System (INIS)

    Taylor, Edward N.; Franx, Marijn; Quadri, Ryan F.; Damen, Maaike; Hildebrandt, Hendrik; Van Dokkum, Pieter G.; Herrera, David; Gawiser, Eric; Bell, Eric F.; Barrientos, L. Felipe; Blanc, Guillermo A.; Castander, Francisco J.; Gonzalez-Perez, Violeta; Hall, Patrick B.; Kriek, Mariska; Labbe, Ivo; Lira, Paulina; Maza, Jose; Rudnick, Gregory; Treister, Ezequiel

    2009-01-01

    We present a new, K-selected, optical-to-near infrared photometric catalog of the Extended Chandra Deep Field South (ECDFS), making it publicly available to the astronomical community. 22 Imaging and spectroscopy data and catalogs are freely available through the MUSYC Public Data Release webpage: http://www.astro.yale.edu/MUSYC/. The data set is founded on publicly available imaging, supplemented by original z'JK imaging data collected as part of the MUltiwavelength Survey by Yale-Chile (MUSYC). The final photometric catalog consists of photometry derived from UU 38 BVRIz'JK imaging covering the full 1/2 x 1/2 square circ of the ECDFS, plus H-band photometry for approximately 80% of the field. The 5σ flux limit for point sources is K (AB) tot = 22.0. This is also the nominal completeness and reliability limit of the catalog: the empirical completeness for 21.75 85%. We have verified the quality of the catalog through both internal consistency checks, and comparisons to other existing and publicly available catalogs. As well as the photometric catalog, we also present catalogs of photometric redshifts and rest-frame photometry derived from the 10-band photometry. We have collected robust spectroscopic redshift determinations from published sources for 1966 galaxies in the catalog. Based on these sources, we have achieved a (1σ) photometric redshift accuracy of Δz/(1 + z) = 0.036, with an outlier fraction of 7.8%. Most of these outliers are X-ray sources. Finally, we describe and release a utility for interpolating rest-frame photometry from observed spectral energy distributions, dubbed InterRest. 23 InterRest is available via http://www.strw.leidenuniv.nl/~ent/InterRest. Documentation and a complete walkthrough can be found at the same address.

  3. THE SIMPLE SURVEY: OBSERVATIONS, REDUCTION, AND CATALOG

    International Nuclear Information System (INIS)

    Damen, M.; Franx, M.; Taylor, E. N.; Labbe, I.; Van Dokkum, P. G.; Muzzin, A.; Brandt, W. N.; Dickinson, M.; Gawiser, E.; Illingworth, G. D.; Kriek, M.; Marchesini, D.; Papovich, C.; Rix, H.-W.

    2011-01-01

    We present the Spitzer IRAC/MUSYC Public Legacy Survey in the Extended CDF-South (SIMPLE), which consists of deep IRAC observations covering the ∼1600 arcmin 2 area surrounding GOODS-S. The limiting magnitudes of the SIMPLE IRAC mosaics typically are 23.8, 23.6, 21.9, and 21.7, at 3.6 μm, 4.5 μm, 5.8 μm, and 8.0 μm, respectively (5σ total point source magnitudes in AB). The SIMPLE IRAC images are combined with the 10' x 15' GOODS IRAC mosaics in the center. We give detailed descriptions of the observations, data reduction, and properties of the final images, as well as the detection and photometry methods used to build a catalog. Using published optical and near-infrared data from the Multiwavelength Survey by Yale-Chile (MUSYC), we construct an IRAC-selected catalog, containing photometry in UBVRIz'JHK, [3.6 μm], [4.5 μm], [5.8 μm], and [8.0 μm]. The catalog contains 43,782 sources with S/N >5 at 3.6 μm, 19,993 of which have 13-band photometry. We compare this catalog to the publicly available MUSYC and FIREWORKS catalogs and discuss the differences. Using a high signal-to-noise sub-sample of 3391 sources with ([3.6] + [4.5])/2 * >10 11 M sun ) are passively evolving, in agreement with earlier results from surveys covering less area.

  4. Just how wide should 'wide reading' be?

    Science.gov (United States)

    Lipscomb, Martin

    2015-10-01

    Educationalists introduce students to literature search strategies that, with rare exceptions, focus chiefly on the location of primary research reports and systematic reviews of those reports. These sources are, however, unlikely to adequately address the normative and/or metaphysical questions that nurses frequently and legitimately interest themselves in. To meet these interests, non-research texts exploring normative and/or metaphysical topics might and perhaps should, in some situations, be deemed suitable search targets. This seems plausible and, moreover, students are encouraged to 'read widely'. Yet accepting this proposition creates significant difficulties. Specifically, if non-research scholarly sources and artistic or literary (humanities) products dealing with normative/metaphysical issues were included in what are, at present, scientifically orientated searches, it is difficult to draw boundaries around what--if anything--is to be excluded. Engaging with this issue highlights problems with qualitative scholarship's designation as 'evidence'. Thus, absurdly, if qualitative scholarship's findings are labelled evidence because they generate practice-relevant understanding/insight, then any literary or artistic artefact (e.g. a throwaway lifestyle magazine) that generates kindred understandings/insights is presumably also evidence? This conclusion is rejected and it is instead proposed that while artistic, literary, and qualitative inquiries can provide practitioners with powerful and stimulating non-evidential understanding, these sources are not evidence as commonly conceived. © 2015 John Wiley & Sons Ltd.

  5. Wide-Gap Chalcopyrites

    CERN Document Server

    Siebentritt, Susanne

    2006-01-01

    Chalcopyrites, in particular those with a wide band gap, are fascinating materials in terms of their technological potential in the next generation of thin-film solar cells and in terms of their basic material properties. They exhibit uniquely low defect formation energies, leading to unusual doping and phase behavior and to extremely benign grain boundaries. This book collects articles on a number of those basic material properties of wide-gap chalcopyrites, comparing them to their low-gap cousins. They explore the doping of the materials, the electronic structure and the transport through interfaces and grain boundaries, the formation of the electric field in a solar cell, the mechanisms and suppression of recombination, the role of inhomogeneities, and the technological role of wide-gap chalcopyrites.

  6. Ultra wide band antennas

    CERN Document Server

    Begaud, Xavier

    2013-01-01

    Ultra Wide Band Technology (UWB) has reached a level of maturity that allows us to offer wireless links with either high or low data rates. These wireless links are frequently associated with a location capability for which ultimate accuracy varies with the inverse of the frequency bandwidth. Using time or frequency domain waveforms, they are currently the subject of international standards facilitating their commercial implementation. Drawing up a complete state of the art, Ultra Wide Band Antennas is aimed at students, engineers and researchers and presents a summary of internationally recog

  7. World wide biomass resources

    NARCIS (Netherlands)

    Faaij, A.P.C.

    2012-01-01

    In a wide variety of scenarios, policy strategies, and studies that address the future world energy demand and the reduction of greenhouse gas emissions, biomass is considered to play a major role as renewable energy carrier. Over the past decades, the modern use of biomass has increased

  8. Wide angle isotope separator

    International Nuclear Information System (INIS)

    Kantrowitz, A.

    1976-01-01

    A method and apparatus is described for particle separation. The method uses a wide angle radially expanding vapor of a particle mixture. In particular, selective ionization of one isotope type in the particle mixture is produced in a multichamber separator and the ionized isotope type is accelerated out of the path of the vapor expansion for separate collection

  9. Jihadism, Narrow and Wide

    DEFF Research Database (Denmark)

    Sedgwick, Mark

    2015-01-01

    The term “jihadism” is popular, but difficult. It has narrow senses, which are generally valuable, and wide senses, which may be misleading. This article looks at the derivation and use of “jihadism” and of related terms, at definitions provided by a number of leading scholars, and at media usage....... It distinguishes two main groups of scholarly definitions, some careful and narrow, and some appearing to match loose media usage. However, it shows that even these scholarly definitions actually make important distinctions between jihadism and associated political and theological ideology. The article closes...

  10. With eyes wide open

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Pedersen, Chistina Hee

    2013-01-01

    and that vulnerability and discomfort are often overlooked as transformative forces. The analysis draws on data from a classroom context in which university students tested methods for facilitating creative thinking in a course on data production and creativity. The data stem from a session on the method “Lego Serious...... in constructions of group identity when an external facilitator disrupts a context. We argue that the facilitation of creative methods calls for keeping our eyes wide open for tensions, for they are the mulch that improves the soil....

  11. World wide spatial capital.

    Science.gov (United States)

    Sen, Rijurekha; Quercia, Daniele

    2018-01-01

    In its most basic form, the spatial capital of a neighborhood entails that most aspects of daily life are located close at hand. Urban planning researchers have widely recognized its importance, not least because it can be transformed in other forms of capital such as economical capital (e.g., house prices, retail sales) and social capital (e.g., neighborhood cohesion). Researchers have already studied spatial capital from official city data. Their work led to important planning decisions, yet it also relied on data that is costly to create and update, and produced metrics that are difficult to compare across cities. By contrast, we propose to measure spatial capital in cheap and standardized ways around the world. Hence the name of our project "World Wide Spatial Capital". Our measures are cheap as they rely on the most basic information about a city that is currently available on the Web (i.e., which amenities are available and where). They are also standardized because they can be applied in any city in the five continents (as opposed to previous metrics that were mainly applied in USA and UK). We show that, upon these metrics, one could produce insights at the core of the urban planning discipline: which areas would benefit the most from urban interventions; how to inform planning depending on whether a city's activity is mono- or poly-centric; how different cities fare against each other; and how spatial capital correlates with other urban characteristics such as mobility patterns and road network structure.

  12. Weaving a wide net.

    Science.gov (United States)

    Garber, Linda

    2002-10-01

    SUMMARY Any single approach tostudents' heterosexism and homophobia, however well conceived and executed, is most successful when supported by an integrated campus approach to the problem. Taking as a model the multifaceted efforts at California State University, Fresno-a large public institution located in what can be considered the state's Bible Belt-this essay discusses the strengths and logistics of a campus-wide program to address homophobia and alleviate LGBTQ students' feelings of alienation from the institution and their oppression in society. The efforts of CSUF take place at a number of different levels-classroom, academic department, student services, faculty networking-and can be considered a successful work in progress.

  13. World wide spatial capital.

    Directory of Open Access Journals (Sweden)

    Rijurekha Sen

    Full Text Available In its most basic form, the spatial capital of a neighborhood entails that most aspects of daily life are located close at hand. Urban planning researchers have widely recognized its importance, not least because it can be transformed in other forms of capital such as economical capital (e.g., house prices, retail sales and social capital (e.g., neighborhood cohesion. Researchers have already studied spatial capital from official city data. Their work led to important planning decisions, yet it also relied on data that is costly to create and update, and produced metrics that are difficult to compare across cities. By contrast, we propose to measure spatial capital in cheap and standardized ways around the world. Hence the name of our project "World Wide Spatial Capital". Our measures are cheap as they rely on the most basic information about a city that is currently available on the Web (i.e., which amenities are available and where. They are also standardized because they can be applied in any city in the five continents (as opposed to previous metrics that were mainly applied in USA and UK. We show that, upon these metrics, one could produce insights at the core of the urban planning discipline: which areas would benefit the most from urban interventions; how to inform planning depending on whether a city's activity is mono- or poly-centric; how different cities fare against each other; and how spatial capital correlates with other urban characteristics such as mobility patterns and road network structure.

  14. Wide area monitoring study

    International Nuclear Information System (INIS)

    Wogman, N.A.; Holdren, G.R. Jr.

    1999-01-01

    Environmental sampling can be used to complement the safeguarding of nuclear material, especially in the detection of undeclared nuclear activities. Routine monitoring of nuclear installations has provided valuable information about the fate of key signature materials within different environmental settings. The approach collates information regarding the generation of individual radiochemical signatures within different nuclear processes, the potential for release of these signatures to the environment and, the chemical form and mobility of the signatures in environmental media along which the material could migrate. Meteorological, geological and hydrological information is used to determine where to sample, what to sample, and how often to sample to provide the greatest likelihood for detection. Multiple strategies can be used to implement wide area monitoring for safeguards purposes. The most complex, and expensive of these, involves establishing extensive networks of fixed location sampling sites. The sites would be operated continuously, and would be instrumented with automated sampling, analysis, and communication equipment to relay information regarding potential anomalies to control centers in near-real time. Alternative strategies can be used to supplement fixed location monitoring equipment, especially in regions that cannot support (financially or logistically) the fixed stations. Through combinations of these various strategies, using a variety of environmental media to monitor a region, we believe that a competent network, one with a quantifiable probability for detecting undeclared nuclear activities, can be designed. While this approach cannot and should not replace other inspection and monitoring activities, it can potentially contribute valuable information to an international safeguards system. (author)

  15. Wide Awake Hand Surgery.

    Science.gov (United States)

    Lied, Line; Borchgrevink, Grethe E; Finsen, Vilhjalmur

    2017-09-01

    "Wide awake hand surgery", where surgery is performed in local anaesthesia with adrenaline, without sedation or a tourniquet, has become widespread in some countries. It has a number of potential advantages and we wished to evaluate it among our patients. All 122 patients treated by this method during one year were evaluated by the surgeons and the patients on a numerical scale from 0 (best/least) to 10 (worst/most). Theatre time was compared to that recorded for a year when regional or general anaesthesia had been used. The patients' mean score for the general care they had received was 0.1 (SD 0.6), for pain during lidocaine injection 2.4 (SD 2.2), for pain during surgery 0.9 (SD 1.5), and for other discomfort during surgery 0.5 (SD 1.4). Eight reported that they would want general anaesthesia if they were to be operated again. The surgeons' mean evaluation of bleeding during surgery was 1.6 (SD 1.8), oedema during surgery 0.4 (SD 1.1), general disadvantages with the method 1.0 (SD 1.6) and general advantages 6.5 (SD 4.3). The estimation of advantages was 9.9 (DS 0.5) for tendon suture. 28 patients needed intra-operative additional anaesthesia. The proportion was lower among trained hand surgeons and fell significantly during the study period. Non-surgical theatre time was 46 (SD 15) minutes during the study period and 55 (SD 22) minutes during the regional/general period (p theatre.

  16. UNUSUALLY WIDE BINARIES: ARE THEY WIDE OR UNUSUAL?

    International Nuclear Information System (INIS)

    Kraus, Adam L.; Hillenbrand, Lynne A.

    2009-01-01

    We describe an astrometric and spectroscopic campaign to confirm the youth and association of a complete sample of candidate wide companions in Taurus and Upper Sco. Our survey found 15 new binary systems (three in Taurus and 12 in Upper Sco) with separations of 3''-30'' (500-5000 AU) among all of the known members with masses of 2.5-0.012 M sun . The total sample of 49 wide systems in these two regions conforms to only some expectations from field multiplicity surveys. Higher mass stars have a higher frequency of wide binary companions, and there is a marked paucity of wide binary systems near the substellar regime. However, the separation distribution appears to be log-flat, rather than declining as in the field, and the mass ratio distribution is more biased toward similar-mass companions than the initial mass function or the field G-dwarf distribution. The maximum separation also shows no evidence of a limit at ∼ sun . We attribute this result to the post-natal dynamical sculpting that occurs for most field systems; our binary systems will escape to the field intact, but most field stars are formed in denser clusters and undergo significant dynamical evolution. In summary, only wide binary systems with total masses ∼ sun appear to be 'unusually wide'.

  17. System Wide Information Management (SWIM)

    Science.gov (United States)

    Hritz, Mike; McGowan, Shirley; Ramos, Cal

    2004-01-01

    This viewgraph presentation lists questions regarding the implementation of System Wide Information Management (SWIM). Some of the questions concern policy issues and strategies, technology issues and strategies, or transition issues and strategies.

  18. World-wide environmental problems

    International Nuclear Information System (INIS)

    Wohlers, H.C.

    1975-01-01

    Man and the physical and natural resources necessary to support him in a civilized society are on a collision course. It is simple to say that man cannot continue to grow in number at an ever-increasing rate without a destructive effect upon the environment. Positive scientific proof for this impending calamity is not now available, yet many indications--sometimes physical and sometimes natural--point toward major world-wide environmental troubles in the near future. A number of environmental problems are described, particularly as they relate to the total world system. A computer model simulating future world-wide environmental trends from 1900 to 2100 A.D. is evaluated and suggested as a major tool for data-gathering purposes to determine the extent of world-wide environmental problems. It is suggested that scientists take an active role in the study of the environment, particularly in relation to man's future on earth

  19. Wide gap semiconductor microwave devices

    International Nuclear Information System (INIS)

    Buniatyan, V V; Aroutiounian, V M

    2007-01-01

    A review of properties of wide gap semiconductor materials such as diamond, diamond-like carbon films, SiC, GaP, GaN and AlGaN/GaN that are relevant to electronic, optoelectronic and microwave applications is presented. We discuss the latest situation and perspectives based on experimental and theoretical results obtained for wide gap semiconductor devices. Parameters are taken from the literature and from some of our theoretical works. The correspondence between theoretical results and parameters of devices is critically analysed. (review article)

  20. World Wide Web Homepage Design.

    Science.gov (United States)

    Tillman, Michael L.

    This paper examines hypermedia design and draws conclusions about how educational research and theory applies to various aspects of World Wide Web (WWW) homepage design. "Hypermedia" is defined as any collection of information which may be textual, graphical, visual, or auditory in nature and which may be accessed via a nonlinear route.…

  1. The World Wide Web Revisited

    Science.gov (United States)

    Owston, Ron

    2007-01-01

    Nearly a decade ago the author wrote in one of the first widely-cited academic articles, Educational Researcher, about the educational role of the web. He argued that educators must be able to demonstrate that the web (1) can increase access to learning, (2) must not result in higher costs for learning, and (3) can lead to improved learning. These…

  2. Wide Bandgap Extrinsic Photoconductive Switches

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, James S. [State Univ. of New York (SUNY), Plattsburgh, NY (United States); Univ. of California, Davis, CA (United States)

    2012-01-20

    Photoconductive semiconductor switches (PCSS) have been investigated since the late 1970s. Some devices have been developed that withstand tens of kilovolts and others that switch hundreds of amperes. However, no single device has been developed that can reliably withstand both high voltage and switch high current. Yet, photoconductive switches still hold the promise of reliable high voltage and high current operation with subnanosecond risetimes. Particularly since good quality, bulk, single crystal, wide bandgap semiconductor materials have recently become available. In this chapter we will review the basic operation of PCSS devices, status of PCSS devices and properties of the wide bandgap semiconductors 4H-SiC, 6H-SiC and 2H-GaN.

  3. Wide range neutron flux monitor

    International Nuclear Information System (INIS)

    Endo, Yorimasa; Fukushima, Toshiki.

    1983-01-01

    Purpose: To provide a wide range neutron-flux monitor adapted such that the flux monitoring function and alarming function can automatically by shifted from pulse counting system to cambel method system. Constitution: A wide range neutron-flux monitor comprises (la) pulse counting system and (lb) cambel-method system for inputting detection signals from neutron detectors and separating them into signals for the pulse measuring system and the cambel measuring system, (2) overlap detection and calculation circuit for detecting the existence of the overlap of two output signals from the (la) and (lb) systems, and (3) trip circuit for judging the abnormal state of neutron detectors upon input of the detection signals. (Seki, T.)

  4. NCenter wide band neutrino beam

    International Nuclear Information System (INIS)

    Stutte, L.G.

    1985-01-01

    This memo describes the physical properties of the currently operating N-Center wide band neutrino beam---commonly called the triplet train, following a past tradition of a triplet lens configuration. In reality, in order to gain a larger momentum acceptance and to minimize the angular divergence of the beam, a quadruplet beam (4 lenses) employing point-to-parallel optics at a central momentum of 300 GeV was built. 6 refs., 13 figs., 1 tab

  5. Wide range neutron detection system

    International Nuclear Information System (INIS)

    Todt, W.H. Sr.

    1978-01-01

    A neutron detection system for reactor control is described which is operable over a wide range of neutron flux levels. The system includes a fission type ionization chamber neutron detector, means for gamma and alpha signal compensation, and means for operating the neutron detector in the pulse counting mode for low neutron flux levels, and in the direct current mode for high neutron flux levels

  6. Wide and High Additive Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Post, Brian K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Roschli, Alex C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    The goal of this project is to develop and demonstrate the enabling technologies for Wide and High Additive Manufacturing (WHAM). WHAM will open up new areas of U.S. manufacturing for very large tooling in support of the transportation and energy industries, significantly reducing cost and lead time. As with Big Area Additive Manufacturing (BAAM), the initial focus is on the deposition of composite materials.

  7. Wide Bandgap Extrinsic Photoconductive Switches

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, James S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-07-03

    Semi-insulating Gallium Nitride, 4H and 6H Silicon Carbide are attractive materials for compact, high voltage, extrinsic, photoconductive switches due to their wide bandgap, high dark resistance, high critical electric field strength and high electron saturation velocity. These wide bandgap semiconductors are made semi-insulating by the addition of vanadium (4H and 6HSiC) and iron (2H-GaN) impurities that form deep acceptors. These deep acceptors trap electrons donated from shallow donor impurities. The electrons can be optically excited from these deep acceptor levels into the conduction band to transition the wide bandgap semiconductor materials from a semi-insulating to a conducting state. Extrinsic photoconductive switches with opposing electrodes have been constructed using vanadium compensated 6H-SiC and iron compensated 2H-GaN. These extrinsic photoconductive switches were tested at high voltage and high power to determine if they could be successfully used as the closing switch in compact medical accelerators.

  8. World wide developments in shortwall and wide web mining techniques

    Energy Technology Data Exchange (ETDEWEB)

    Pollard, T

    1975-11-01

    The paper describes the progress to date with continuous pillar extraction, and how the typical longwall powered support has been modified to be both strong enough and stable enough to provide roof support for very wide webs. It also describes the operating systems which have been specially designed. The next stages of development are discussed, particularly the provision of continuous conveyor haulage in place of the present-day shuttle car. The author suggests that marrying American coal-getting technology and British roof support technology might increase productivity.

  9. Wide-range voltage modulation

    International Nuclear Information System (INIS)

    Rust, K.R.; Wilson, J.M.

    1992-06-01

    The Superconducting Super Collider's Medium Energy Booster Abort (MEBA) kicker modulator will supply a current pulse to the abort magnets which deflect the proton beam from the MEB ring into a designated beam stop. The abort kicker will be used extensively during testing of the Low Energy Booster (LEB) and the MEB rings. When the Collider is in full operation, the MEBA kicker modulator will abort the MEB beam in the event of a malfunction during the filling process. The modulator must generate a 14-μs wide pulse with a rise time of less than 1 μs, including the delay and jitter times. It must also be able to deliver a current pulse to the magnet proportional to the beam energy at any time during ramp-up of the accelerator. Tracking the beam energy, which increases from 12 GeV at injection to 200 GeV at extraction, requires the modulator to operate over a wide range of voltages (4 kV to 80 kV). A vacuum spark gap and a thyratron have been chosen for test and evaluation as candidate switches for the abort modulator. Modulator design, switching time delay, jitter and pre-fire data are presented

  10. Improving the wide resonance approximation

    International Nuclear Information System (INIS)

    Aboustta, Mohamed A.; Martinez, Aquilino S.

    1999-01-01

    A resonance is considered wide if its practical width, in energy, exceeds the average energy loss per collision, E(1-α A )/2, of the absorbing material. When the mass number, A, is taken infinite, the scattering produces only a change in the direction of motion of the neutron and not in its energy. Based on this assumption, the integral in the slowing-down equation describing the contribution of the resonant absorber is evaluated by taking its limit when α A →1. This work questions the necessity to take such a limit and shows that it is still possible to obtain a simple and more accurate expression for the integral without taking such limit

  11. Improving the wide resonance approximation

    Energy Technology Data Exchange (ETDEWEB)

    Aboustta, Mohamed A.; Martinez, Aquilino S

    1999-03-01

    A resonance is considered wide if its practical width, in energy, exceeds the average energy loss per collision, E(1-{alpha}{sub A})/2, of the absorbing material. When the mass number, A, is taken infinite, the scattering produces only a change in the direction of motion of the neutron and not in its energy. Based on this assumption, the integral in the slowing-down equation describing the contribution of the resonant absorber is evaluated by taking its limit when {alpha}{sub A}{yields}1. This work questions the necessity to take such a limit and shows that it is still possible to obtain a simple and more accurate expression for the integral without taking such limit.

  12. Enterprise wide transparent information access

    International Nuclear Information System (INIS)

    Brown, J.

    1995-05-01

    The information management needs of the Department of Energy (DOE) represents a fertile domain for the development of highly sophisticated yet intuitive enterprise-wide computing solutions. These solutions must support business operations, research agendas, technology development efforts, decision support, and other application areas with a user base ranging from technical staff to the highest levels of management. One area of primary interest is in the Environmental Restoration and Waste Management Branch of DOE. In this arena, the issue of tracking and managing nuclear waste related to the long legacy of prior defense production and research programs is one of high visibility and great concern. The Tank Waste Information Network System (TWINS) application has been created by the Pacific Northwest Laboratory (PNL) for the DOE to assist in managing and accessing the information related to this mission. The TWINS solution addresses many of the technical issues faced by other efforts to provide integrated information access to a wide variety of stakeholders. TWINS provides secure transparent access to distributed heterogeneous multimedia information sources from around the DOE complex. The users interact with the information through a consistent user interface that presents the desired data in a common format regardless of the structure of the source information. The solutions developed by the TWINS project represent an integration of several technologies and products that can be applied to other mission areas within DOE and other government agencies. These solutions are now being applied to public and private sector problem domains as well. The successful integration and inter-operation of both commercial and custom modules into a flexible and extensible information architecture will help ensure that new problems facing DOE and other clients can be addressed more rapidly in the future by re-use of existing tools and techniques proven viable through the TWINS efforts

  13. Wide area continuous offender monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Hoshen, J. [Lucent Technologies (United States); Drake, G. [New Mexico Dept. of Corrections, Santa Fe, NM (United States); Spencer, D. [Sandia National Labs., Albuquerque, NM (United States)

    1996-11-01

    The corrections system in the U.S. is supervising over five million offenders. This number is rising fast and so are the direct and indirect costs to society. To improve supervision and reduce the cost of parole and probation, first generation home arrest systems were introduced in 1987. While these systems proved to be helpful to the corrections system, their scope is rather limited because they only cover an offender at a single location and provide only a partial time coverage. To correct the limitations of first-generation systems, second-generation wide area continuous electronic offender monitoring systems, designed to monitor the offender at all times and locations, are now on the drawing board. These systems use radio frequency location technology to track the position of offenders. The challenge for this technology is the development of reliable personal locator devices that are small, lightweight, with long operational battery life, and indoors/outdoors accuracy of 100 meters or less. At the center of a second-generation system is a database that specifies the offender`s home, workplace, commute, and time the offender should be found in each. The database could also define areas from which the offender is excluded. To test compliance, the system would compare the observed coordinates of the offender with the stored location for a given time interval. Database logfiles will also enable law enforcement to determine if a monitored offender was present at a crime scene and thus include or exclude the offender as a potential suspect.

  14. Wide Field Radio Transient Surveys

    Science.gov (United States)

    Bower, Geoffrey

    2011-04-01

    The time domain of the radio wavelength sky has been only sparsely explored. Nevertheless, serendipitous discovery and results from limited surveys indicate that there is much to be found on timescales from nanoseconds to years and at wavelengths from meters to millimeters. These observations have revealed unexpected phenomena such as rotating radio transients and coherent pulses from brown dwarfs. Additionally, archival studies have revealed an unknown class of radio transients without radio, optical, or high-energy hosts. The new generation of centimeter-wave radio telescopes such as the Allen Telescope Array (ATA) will exploit wide fields of view and flexible digital signal processing to systematically explore radio transient parameter space, as well as lay the scientific and technical foundation for the Square Kilometer Array. Known unknowns that will be the target of future transient surveys include orphan gamma-ray burst afterglows, radio supernovae, tidally-disrupted stars, flare stars, and magnetars. While probing the variable sky, these surveys will also provide unprecedented information on the static radio sky. I will present results from three large ATA surveys (the Fly's Eye survey, the ATA Twenty CM Survey (ATATS), and the Pi GHz Survey (PiGSS)) and several small ATA transient searches. Finally, I will discuss the landscape and opportunities for future instruments at centimeter wavelengths.

  15. Wide spectral band beam analysis

    Science.gov (United States)

    Aharon, Oren

    2015-03-01

    The reality in laser beam profiling is that measurements are performed over a wide spectrum of wavelengths and power ranges. Many applications use multiple laser wavelengths with very different power levels, a fact which dictates a need for a better measuring tool. Rapid progress in the fiber laser area has increased the demand for lasers in the wavelength range of 900 - 1030 nm, while the telecommunication market has increased the demand for wavelength range of 1300nm - 1600 nm, on the other hand the silicone chip manufacturing and mass production requirements tend to lower the laser wavelength towards the 190nm region. In many cases there is a need to combine several lasers together in order to perform a specific task. A typical application is to combine one visible laser for pointing, with a different laser for material processing with a very different wavelength and power level. The visible laser enables accurate pointing before the second laser is operated. The beam profile of the intensity distribution is an important parameter that indicates how a laser beam will behave in an application. Currently a lab, where many different lasers are used, will find itself using various laser beam profilers from several vendors with different specifications and accuracies. It is the propose of this article to present a technological breakthrough in the area of detectors, electronics and optics allowing intricate measurements of lasers with different wavelength and with power levels that vary many orders of magnitude by a single beam profiler.

  16. Unit 148 - World Wide Web Basics

    OpenAIRE

    148, CC in GIScience; Yeung, Albert K.

    2000-01-01

    This unit explains the characteristics and the working principles of the World Wide Web as the most important protocol of the Internet. Topics covered in this unit include characteristics of the World Wide Web; using the World Wide Web for the dissemination of information on the Internet; and using the World Wide Web for the retrieval of information from the Internet.

  17. Directional Wide-Angle Range Finder (DWARF)

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation, the Directional Wide-Angle Range Finder (DWARF) is the creation of a laser range-finder with a wide field-of-view (FOV) and a directional...

  18. Introduction to the world wide web.

    Science.gov (United States)

    Downes, P K

    2007-05-12

    The World Wide Web used to be nicknamed the 'World Wide Wait'. Now, thanks to high speed broadband connections, browsing the web has become a much more enjoyable and productive activity. Computers need to know where web pages are stored on the Internet, in just the same way as we need to know where someone lives in order to post them a letter. This section explains how the World Wide Web works and how web pages can be viewed using a web browser.

  19. Wide-Field Imaging Using Nitrogen Vacancies

    Science.gov (United States)

    Englund, Dirk Robert (Inventor); Trusheim, Matthew Edwin (Inventor)

    2017-01-01

    Nitrogen vacancies in bulk diamonds and nanodiamonds can be used to sense temperature, pressure, electromagnetic fields, and pH. Unfortunately, conventional sensing techniques use gated detection and confocal imaging, limiting the measurement sensitivity and precluding wide-field imaging. Conversely, the present sensing techniques do not require gated detection or confocal imaging and can therefore be used to image temperature, pressure, electromagnetic fields, and pH over wide fields of view. In some cases, wide-field imaging supports spatial localization of the NVs to precisions at or below the diffraction limit. Moreover, the measurement range can extend over extremely wide dynamic range at very high sensitivity.

  20. Wireless Wide Area Networks for School Districts.

    Science.gov (United States)

    Nair, Prakash

    This paper considers a basic question that many schools districts face in attempting to develop affordable, expandable district-wide computer networks that are resistant to obsolescence: Should these wide area networks (WANs) employ wireless technology, stick to venerable hard-wired solutions, or combine both. This publication explores the…

  1. World-Wide Web: The Information Universe.

    Science.gov (United States)

    Berners-Lee, Tim; And Others

    1992-01-01

    Describes the World-Wide Web (W3) project, which is designed to create a global information universe using techniques of hypertext, information retrieval, and wide area networking. Discussion covers the W3 data model, W3 architecture, the document naming scheme, protocols, document formats, comparison with other systems, experience with the W3…

  2. Reduction operator for wide-SIMDs reconsidered

    NARCIS (Netherlands)

    Waeijen, L.J.W.; She, D.; Corporaal, H.; He, Y.

    2014-01-01

    It has been shown that wide Single Instruction Multiple Data architectures (wide-SIMDs) can achieve high energy efficiency, especially in domains such as image and vision processing. In these and various other application domains, reduction is a frequently encountered operation, where multiple input

  3. Innovation in Science Education - World-Wide.

    Science.gov (United States)

    Baez, Albert V.

    The purpose of this book is to promote improvements in science education, world-wide, but particularly in developing countries. It is addressed to those in positions to make effective contributions to the improvement of science education. The world-wide role of science education, the goals of innovative activities, past experience in efforts to…

  4. Michelson wide-field stellar interferometry

    NARCIS (Netherlands)

    Montilla, I.

    2004-01-01

    The main goal of this thesis is to develop a system to permit wide field operation of Michelson Interferometers. A wide field of view is very important in applications such as the observation of extended or multiple objects, the fringe acquisition and/ or tracking on a nearby unresolved object, and

  5. Management van World-Wide Web Servers

    NARCIS (Netherlands)

    van Hengstum, F.P.H.; Pras, Aiko

    1996-01-01

    Het World Wide Web is een populaire Internet toepassing waarmee het mogelijk is documenten aan willekeurige Internet gebruikers aan te bieden. Omdat hiervoor nog geen voorzieningen zijn getroffen, was het tot voor kort niet goed mogelijk het World Wide Web op afstand te beheren. De Universiteit

  6. Consistency in the World Wide Web

    DEFF Research Database (Denmark)

    Thomsen, Jakob Grauenkjær

    Tim Berners-Lee envisioned that computers will behave as agents of humans on the World Wide Web, where they will retrieve, extract, and interact with information from the World Wide Web. A step towards this vision is to make computers capable of extracting this information in a reliable...... and consistent way. In this dissertation we study steps towards this vision by showing techniques for the specication, the verication and the evaluation of the consistency of information in the World Wide Web. We show how to detect certain classes of errors in a specication of information, and we show how...... the World Wide Web, in order to help perform consistent evaluations of web extraction techniques. These contributions are steps towards having computers reliable and consistently extract information from the World Wide Web, which in turn are steps towards achieving Tim Berners-Lee's vision. ii...

  7. The World Wide Web of War

    National Research Council Canada - National Science Library

    Smith, Craig A

    2006-01-01

    Modern communications, combined with the near instantaneous publication of information on the World Wide Web, are providing the means to dramatically affect the pursuit, conduct, and public opinion of war on both sides...

  8. Nasa-wide Standard Administrative Systems

    Science.gov (United States)

    Schneck, P.

    1984-01-01

    Factors to be considered in developing agency-wide standard administrative systems for NASA include uniformity of hardware and software; centralization vs. decentralization; risk exposure; and models for software development.

  9. IOT Overview: Wide-Field Imaging

    Science.gov (United States)

    Selman, F. J.

    The Wide Field Imager (WFI) instrument at La Silla has been the workhorse of wide-field imaging instruments at ESO for several years. In this contribution I will summarize the issues relating to its productivity for the community both in terms of the quality and quantity of data that has come out of it. Although only surveys of limited scope have been completed using WFI, it is ESO's stepping-stone to the new generation of survey telescopes.

  10. AA, wide quadrupole on measurement stand

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Please look up 8101024 first. Shims and washers on the wide quadrupoles (QFW, QDW; located in the lattice where dispersion was large) served mostly for corrections of those lattice parameters which were a function of momentum. After mounting shims and washers, the quadrupoles were measured to determine their magnetic centre and to catalogue the effect of washer constellations. Raymond Brown is busy measuring a wide quad.

  11. AA, assembly of wide bending magnet

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    The very particular lattice of the AA required 2 types of dipoles (bending magnets; BST, short and wide; BLG, long and narrow). The wide ones had a steel length of 2.71 m, a "good field" width of 0.564 m, and a weight of about 75 t. Here we see the copper coils being hoisted onto the lower half of a BST. See also 7811105, 8006050. For a BLG, see 8001044.

  12. Emergency Medicine for medical students world wide!

    DEFF Research Database (Denmark)

    Perinpam, Larshan; Thi Huynh, Anh-Nhi

    2015-01-01

    A guest blog from Larshan Perinpam (President of ISAEM) and Anh-Nhi Thi Huynh (Vice president of external affairs, ISAEM) - http://blogs.bmj.com/emj/2015/04/17/emergency-medicine-for-medical-students-world-wide/......A guest blog from Larshan Perinpam (President of ISAEM) and Anh-Nhi Thi Huynh (Vice president of external affairs, ISAEM) - http://blogs.bmj.com/emj/2015/04/17/emergency-medicine-for-medical-students-world-wide/...

  13. Wide dynamic range beam profile monitor

    International Nuclear Information System (INIS)

    Lee, D.M.; Brown, D.; Hardekopf, R.; Bilskie, J.R.; van Dyck, O.B.V.

    1985-01-01

    An economical harp multiplexer system has been developed to achieve a wide dynamic range. The harp system incorporates a pneumatically actuated harp detector with ceramic boards and carbon wires; a high-sensitivity multiplexer packaged in a double-wide NIM module; and flat, shielded ribbon cable consisting of individual twisted pairs. The system multiplexes 30 wires in each of the x and y planes simultaneously and operates with or without computer control. The system has operated in beams of 100 nA to 1 mA, 1- to 120-Hz repetition rate, with a signal-to-noise ratio of greater than 10/1

  14. So Wide a Web, So Little Time.

    Science.gov (United States)

    McConville, David; And Others

    1996-01-01

    Discusses new trends in the World Wide Web. Highlights include multimedia; digitized audio-visual files; compression technology; telephony; virtual reality modeling language (VRML); open architecture; and advantages of Java, an object-oriented programming language, including platform independence, distributed development, and pay-per-use software.…

  15. Enterprise-Wide Process & Performance Excellence:

    DEFF Research Database (Denmark)

    Edgeman, Rick; Kristensen, Kai; Eskildsen, Jacob Kjær

    2013-01-01

    Program value proposition, content, organization, and strategy are elaborated herein. This elaboration is the result of careful study of business and social trends, along with careful listening to collaborating enterprises. It is in this latter sense that the Enterprise-Wide Process & Performance...... Excellence certificate program is a product of a co-creation process....

  16. Review The Ooty Wide Field Array

    Indian Academy of Sciences (India)

    c Indian Academy of Sciences. DOI 10.1007/s12036-017-9430-4. Review. The Ooty Wide Field ... salient features of the upgrade, as well as its main science drivers. There are three ..... tecture for low frequency arrays, Ph.D. thesis, Jawaharalal.

  17. Happy 20th Birthday, World Wide Web!

    CERN Multimedia

    2009-01-01

    On 13 March CERN celebrated the 20th anniversary of the World Wide Web. Check out the video interview with Web creator Tim Berners-Lee and find out more about the both the history and future of the Web. To celebrate CERN also launched a brand new website, CERNland, for kids.

  18. Wide Band to ''Double Band'' upgrade

    International Nuclear Information System (INIS)

    Kasper, P.; Currier, R.; Garbincius, P.; Butler, J.

    1988-06-01

    The Wide Band beam currently uses electrons obtained from secondary photon conversions to produce the photon beam incident on the experimental targets. By transporting the positrons produced in these conversions as well as the electrons it is possible to almost double the number of photons delivered to the experiments per primary beam proton. 11 figs

  19. WorldWide Web: Hypertext from CERN.

    Science.gov (United States)

    Nickerson, Gord

    1992-01-01

    Discussion of software tools for accessing information on the Internet focuses on the WorldWideWeb (WWW) system, which was developed at the European Particle Physics Laboratory (CERN) in Switzerland to build a worldwide network of hypertext links using available networking technology. Its potential for use with multimedia documents is also…

  20. Wide-band segmented power distribution networks

    NARCIS (Netherlands)

    Tereshchenko, O.V.; Buesink, Frederik Johannes Karel; Leferink, Frank Bernardus Johannes

    2013-01-01

    This paper discusses a novel design of Power Distribution Network (PDN). By physical structuring of the power plane into repetitive symmetrical and asymmetrical segments of varying size, suppression of the propagation of unwanted noise throughout the PDN over a wide frequency range is achieved.

  1. Digital demodulator for wide bandwidth SAR

    DEFF Research Database (Denmark)

    Jørgensen, Jørn Hjelm

    2000-01-01

    A novel approach to the design of efficient digital quadrature demodulators for wide bandwidth SAR systems is described. Efficiency is obtained by setting the intermediate frequency to 1/4 the ADC sampling frequency. One channel is made filter-free by synchronizing the local oscillator...

  2. Utilization of the world wide web

    International Nuclear Information System (INIS)

    Mohr, P.; Mallard, G.; Ralchenko, U.; Schultz, D.

    1998-01-01

    Two aspects of utilization of the World Wide Web are examined: (i) the communication of technical data through web cites that provide repositories of atomic and molecular data accessible through searchable databases; and (ii) the communication about issues of mutual concern among data producers, data compilers and evaluators, and data users. copyright 1998 American Institute of Physics

  3. News Resources on the World Wide Web.

    Science.gov (United States)

    Notess, Greg R.

    1996-01-01

    Describes up-to-date news sources that are presently available on the Internet and World Wide Web. Highlights include electronic newspapers; AP (Associated Press) sources and Reuters; sports news; stock market information; New York Times; multimedia capabilities, including CNN Interactive; and local and regional news. (LRW)

  4. Telepresence Robots in the Wide Wild World

    NARCIS (Netherlands)

    Bruijnes, Merijn; van Delden, Robby; Vroon, Jered Hendrik

    2017-01-01

    Mobile remote presence systems (MRPs) are the logical next step in telepresence, but what are the ethical, social, legal, and technical implications of such systems going into the wide wild world? We explored these potential issues by immersing ourselves in a range of possible applications by

  5. Lensless imaging for wide field of view

    Science.gov (United States)

    Nagahara, Hajime; Yagi, Yasushi

    2015-02-01

    It is desirable to engineer a small camera with a wide field of view (FOV) because of current developments in the field of wearable cameras and computing products, such as action cameras and Google Glass. However, typical approaches for achieving wide FOV, such as attaching a fisheye lens and convex mirrors, require a trade-off between optics size and the FOV. We propose camera optics that achieve a wide FOV, and are at the same time small and lightweight. The proposed optics are a completely lensless and catoptric design. They contain four mirrors, two for wide viewing, and two for focusing the image on the camera sensor. The proposed optics are simple and can be simply miniaturized, since we use only mirrors for the proposed optics and the optics are not susceptible to chromatic aberration. We have implemented the prototype optics of our lensless concept. We have attached the optics to commercial charge-coupled device/complementary metal oxide semiconductor cameras and conducted experiments to evaluate the feasibility of our proposed optics.

  6. Re-Framing the World Wide Web

    Science.gov (United States)

    Black, August

    2011-01-01

    The research presented in this dissertation studies and describes how technical standards, protocols, and application programming interfaces (APIs) shape the aesthetic, functional, and affective nature of our most dominant mode of online communication, the World Wide Web (WWW). I examine the politically charged and contentious battle over browser…

  7. The LOFT wide field monitor simulator

    DEFF Research Database (Denmark)

    Donnarumma, I.; Evangelista, Y.; Campana, R.

    2012-01-01

    We present the simulator we developed for the Wide Field Monitor (WFM) aboard the Large Observatory For Xray Timing (LOFT) mission, one of the four ESA M3 candidate missions considered for launch in the 2022–2024 timeframe. The WFM is designed to cover a large FoV in the same bandpass as the Large...

  8. Internet and The World Wide Web

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 2. Internet and The World Wide Web. Neelima Shrikhande. General Article Volume 2 Issue 2 February 1997 pp 64-74. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/002/02/0064-0074 ...

  9. AA, wide quadrupole on measurement stand

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Please look up 8101024 and 8103203 first. Wide quadrupole (QFW, QDW) with end-shims and shimming washers on the measurement stand. With the measurement coil one measured the harmonics of the magnetic field, determined the magnetic centre, and catalogued the effect of washer constellations.

  10. Wide-Screen Cinema and Stereophonic Sound.

    Science.gov (United States)

    Wysotsky, Michael Z.

    Developments in the techniques of wide screen cinema and stereophonic sound throughout the world are detailed in this book. Particular attention is paid to progress in the Soviet Union in these fields. Special emphasis is placed on the Soviet view of stereophonic sound as a vital adjunct in the search for enchanced realism as opposed to the…

  11. Wide-Scale Adoption of Photovoltaic Energy

    DEFF Research Database (Denmark)

    Yang, Yongheng; Enjeti, Prasad; Blaabjerg, Frede

    2015-01-01

    Current grid standards largely require that low-power (e.g., several kilowatts) single-phase photovoltaic (PV) systems operate at unity power factor (PF) with maximum power point tracking (MPPT), and disconnect from the grid under grid faults by means of islanding detection. However, in the case...... of wide-scale penetration of single-phase PV systems in the distributed grid, disconnection under grid faults can contribute to 1) voltage flickers, 2) power outages, and 3) system instability. This article explores grid code modifications for a wide-scale adoption of PV systems in the distribution grid....... In addition, based on the fact that Italy and Japan have recently undertaken a major review of standards for PV power conversion systems connected to low-voltage networks, the importance of low voltage ride-through (LVRT) for single-phase PV power systems under grid faults is considered, along with three...

  12. Analytical approximations for wide and narrow resonances

    International Nuclear Information System (INIS)

    Suster, Luis Carlos; Martinez, Aquilino Senra; Silva, Fernando Carvalho da

    2005-01-01

    This paper aims at developing analytical expressions for the adjoint neutron spectrum in the resonance energy region, taking into account both narrow and wide resonance approximations, in order to reduce the numerical computations involved. These analytical expressions, besides reducing computing time, are very simple from a mathematical point of view. The results obtained with this analytical formulation were compared to a reference solution obtained with a numerical method previously developed to solve the neutron balance adjoint equations. Narrow and wide resonances of U 238 were treated and the analytical procedure gave satisfactory results as compared with the reference solution, for the resonance energy range. The adjoint neutron spectrum is useful to determine the neutron resonance absorption, so that multigroup adjoint cross sections used by the adjoint diffusion equation can be obtained. (author)

  13. Analytical approximations for wide and narrow resonances

    Energy Technology Data Exchange (ETDEWEB)

    Suster, Luis Carlos; Martinez, Aquilino Senra; Silva, Fernando Carvalho da [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear]. E-mail: aquilino@lmp.ufrj.br

    2005-07-01

    This paper aims at developing analytical expressions for the adjoint neutron spectrum in the resonance energy region, taking into account both narrow and wide resonance approximations, in order to reduce the numerical computations involved. These analytical expressions, besides reducing computing time, are very simple from a mathematical point of view. The results obtained with this analytical formulation were compared to a reference solution obtained with a numerical method previously developed to solve the neutron balance adjoint equations. Narrow and wide resonances of U{sup 238} were treated and the analytical procedure gave satisfactory results as compared with the reference solution, for the resonance energy range. The adjoint neutron spectrum is useful to determine the neutron resonance absorption, so that multigroup adjoint cross sections used by the adjoint diffusion equation can be obtained. (author)

  14. Logarithmic circuit with wide dynamic range

    Science.gov (United States)

    Wiley, P. H.; Manus, E. A. (Inventor)

    1978-01-01

    A circuit deriving an output voltage that is proportional to the logarithm of a dc input voltage susceptible to wide variations in amplitude includes a constant current source which forward biases a diode so that the diode operates in the exponential portion of its voltage versus current characteristic, above its saturation current. The constant current source includes first and second, cascaded feedback, dc operational amplifiers connected in negative feedback circuit. An input terminal of the first amplifier is responsive to the input voltage. A circuit shunting the first amplifier output terminal includes a resistor in series with the diode. The voltage across the resistor is sensed at the input of the second dc operational feedback amplifier. The current flowing through the resistor is proportional to the input voltage over the wide range of variations in amplitude of the input voltage.

  15. Promoting and supporting PBL interests world wide

    DEFF Research Database (Denmark)

    Enemark, Stig; Kolmos, Anette; Moesby, Egon

    2006-01-01

    of projects world wide focusing on institutional change toward a more student centred, project organised, and problem based approach to learning. The Centre is also establishing a UCPBL Global Network on Problem Based Learning in order to facilitate better access to and co-operation within the PBL area.......-Based Learning (PBL) in Engineering Education, an increasing number of universities and engineering schools throughout the world are seeking consultancy and cooperation with Aalborg University. The establishment of UCPBL is therefore a timely opportunity to merge the efforts into one organisational structure...... aiming to promote and support PBL interests worldwide. This paper presents the UCPBL profile and plan of action. This includes a wide range of activities such as promoting research and development within the various PBL models and their implementation; Education and training in PBL through offering...

  16. Swell propagation across a wide continental shelf

    OpenAIRE

    Hendrickson, Eric J.

    1996-01-01

    The effects of wave refraction and damping on swell propagation across a wide continental shelf were examined with data from a transect of bottom pressure recorders extending from the beach to the shelf break near Duck, North Carolina. The observations generally show weak variations in swell energy across the shelf during benign conditions, in qualitative agreement with predictions of a spectral refraction model. Although the predicted ray trajectories are quite sensitive to the irregular she...

  17. PENYEBARAN INFORMASI MENGGUNAKAN WWW (WORLD WIDE WEB

    Directory of Open Access Journals (Sweden)

    Ika Atman Satya

    2011-12-01

    Full Text Available Media Informasi secara tradisional telah kita kenai dengan menggunakan koran, televisi, radio dan buku referensi. Media informasi tersebut untuk penyebarannya memerlukan penunjang agar informasi tersebut dapat disebarkan secara lutis. Selain penggunaan media tradisional tersebut penyebaran informasi dengan menggunakan jaringan komputer Internet juga berkembang. Salah satu cara penyebaran informasi dengan menggunakan aplikasi WWW (World Wide Web yang mempunyai kemampuan menggabungkan gambar, text dan suara secara interaktif. Pada tulisan ini akan dibahas tentang kemampuan, penggunaan dan pengembangan server WWW.

  18. Excessive current in wide superconducting films

    International Nuclear Information System (INIS)

    Volotskaya, V.G.; Sivakov, A.G.; Turutanov, O.G.

    1986-01-01

    The resistive state of a wide long film due to superconductivity destruction by current is studied. The voltage-independent excess current I 0 is observed on I-V curves at high transport currents. The two-dimensional image of the current-carrying sample obtained by laser scanning technique in this current range indicates that the whole film is in the resistive state. The current I 0 is measured as a function of magnetic field and SHF power

  19. Economics of area-wide pest control

    International Nuclear Information System (INIS)

    Mumford, J.D.

    2000-01-01

    Area-wide pest management is commonly practised throughout the world, probably much more so than is generally recognised (Lindquist 2000, Klassen 2000). Apart from highly publicised area-wide schemes such as the sterile insect technique (SIT) for fruit flies, pheromone disruption for cotton bollworms and classical biological control, there are many examples of actions such as concerted host plant eradication, enforced closed crop seasons, organised pesticide rotation for resistance management, coordination of resistant crop genotypes, etc., some going back several centuries, which should also be considered as area-wide practices. Each of these is faced with many of the economic issues generally associated with area-wide management which will be discussed below. In general, there are to be four major questions to answer in devising an area-wide pest management programme: 1) Should a particular pest be controlled locally or area-wide? 2) What is an appropriate area over which management should be attempted? 3) Within that area what form of control is most efficient? 4) What level of organisation should be used to get the job done? It should be noted that apart from clearly objective measures such as technical effectiveness (say, mortality) or cost efficiency (mortality per dollar), there are many subjective measures that come into the evaluation of area-wide control due to the element of risk (for example, in quarantine and eradication), the boundaries of externalities (for example, variable probabilities of pesticide drift under different conditions or target organism sensitivities) and time preferences for returns on capital investments (such as insect rearing facilities or research to develop pheromone technologies). As a result of these subjective components, it may sometimes be difficult to reach clearly agreed decisions based on objective economic analyses, even with a consensus on the data used. There are three general classes of economic problems in comparing

  20. A wide field X-ray camera

    International Nuclear Information System (INIS)

    Sims, M.; Turner, M.J.L.; Willingale, R.

    1980-01-01

    A wide field of view X-ray camera based on the Dicke or Coded Mask principle is described. It is shown that this type of instrument is more sensitive than a pin-hole camera, or than a scanning survey of a given region of sky for all wide field conditions. The design of a practical camera is discussed and the sensitivity and performance of the chosen design are evaluated by means of computer simulations. The Wiener Filter and Maximum Entropy methods of deconvolution are described and these methods are compared with each other and cross-correlation using data from the computer simulations. It is shown that the analytic expressions for sensitivity used by other workers are confirmed by the simulations, and that ghost images caused by incomplete coding can be substantially eliminated by the use of the Wiener Filter and the Maximum Entropy Method, with some penalty in computer time for the latter. The cyclic mask configuration is compared with the simple mask camera. It is shown that when the diffuse X-ray background dominates, the simple system is more sensitive and has the better angular resolution. When sources dominate the simple system is less sensitive. It is concluded that the simple coded mask camera is the best instrument for wide field imaging of the X-ray sky. (orig.)

  1. Proceedings of wide band gap semiconductors

    International Nuclear Information System (INIS)

    Moustakas, T.D.; Pankove, J.I.; Hamakawa, Y.

    1992-01-01

    This book contains the proceedings of wide band gap semiconductors. Wide band gap semiconductors are under intense study because of their potential applications in photonic devices in the visible and ultraviolet part of the electromagnetic spectrum, and devices for high temperature, high frequency and high power electronics. Additionally, due to their unique mechanical, thermal, optical, chemical, and electronic properties many wide band gap semiconductors are anticipated to find applications in thermoelectric, electrooptic, piezoelectric and acoustooptic devices as well as protective coatings, hard coatings and heat sinks. Material systems covered in this symposium include diamond, II-VI compounds, III-V nitrides, silicon carbide, boron compounds, amorphous and microcrystalline semiconductors, chalcopyrites, oxides and halides. The various papers addressed recent experimental and theoretical developments. They covered issues related to crystal growth (bulk and thin films), structure and microstructure, defects, doping, optoelectronic properties and device applications. A theoretical session was dedicated to identifying common themes in the heteroepitaxy and the role of defects in doping, compensation and phase stability of this unique class of materials. Important experimental milestones included the demonstrations of bright blue injection luminescence at room temperatures from junctions based on III-V nitrides and a similar result from multiple quantum wells in a ZnSe double heterojunction at liquid nitrogen temperatures

  2. Widely distributed SEP events and pseudostreamers

    Science.gov (United States)

    Panasenco, O.; Panasenco, A.; Velli, M.

    2017-12-01

    Our analysis of the pseudostreamer magnetic topology reveals new interesting implications for understanding SEP acceleration in CMEs. The possible reasons for the wide distribution of some SEP events can be the presence of pseudostreamers in the vicinity of the SEP source region which creates conditions for the existence of strong longitudinal spread of energetic particles as well as an anomalous longitudinal solar wind magnetic field component. We reconstructed the 3D magnetic configurations of pseudostreamers with a potential field source surface (PFSS) model, which uses as a lower boundary condition the magnetic field derived from an evolving surface-flux transport model. In order to estimate the possible magnetic connections between the spacecraft and the SEP source region, we used the Parker spiral, ENLIL and PFSS models. We found that in cases of the wide SEP distributions a specific configuration of magnetic field appears to exist at low solar latitudes all the way around the sun, we named this phenomenon a pseudostreamers belt. It appears that the presence of the well developed pseudostreamer or, rather multiple pseudostreamers, organized into the pseudostreamer belt can be considered as a very favorable condition for wide SEP events.

  3. Calibration device for wide range monitor

    International Nuclear Information System (INIS)

    Kodoku, Masaya; Sato, Toshifumi.

    1989-01-01

    The calibration device for a wide range monitor according to the present invention can continuously calibrate the entire counting regions of a wide range monitor. The wide range monitor detect the reactor power in the neutron source region by means of a pulse counting method and detects the reactor power in the intermediate region by means of a cambell method. A calibration signal outputting means is disposed for continuously outputting, as such calibration signals, pulse number varying signals in which the number of pulses per unit time varies depending on the reactor power in the neutron source region to be simulated and amplitude square means varying signal in which the mean square value of amplitude varies depending on the reactor power in the intermediate region to be simulated. By using both of the calibration signals, calibration can be conducted for the nuclear reactor power in the neutron source region and the intermediate region even if the calibration is made over two regions, further, calibration for the period present over the two region can be conducted easily as well. (I.S.)

  4. THE SPITZER DEEP, WIDE-FIELD SURVEY

    International Nuclear Information System (INIS)

    Ashby, M. L. N.; Brodwin, M.; Stern, D.; Griffith, R.; Eisenhardt, P.; Gorjian, V.; Kozlowski, S.; Kochanek, C. S.; Bock, J. J.; Borys, C.; Brand, K.; Grogin, N. A.; Brown, M. J. I.; Cool, R.; Cooray, A.; Croft, S.; Dey, A.; Eisenstein, D.; Gonzalez, A. H.; Ivison, R. J.

    2009-01-01

    The Spitzer Deep, Wide-Field Survey (SDWFS) is a four-epoch infrared survey of 10 deg. 2 in the Booetes field of the NOAO Deep Wide-Field Survey using the IRAC instrument on the Spitzer Space Telescope. SDWFS, a Spitzer Cycle 4 Legacy project, occupies a unique position in the area-depth survey space defined by other Spitzer surveys. The four epochs that make up SDWFS permit-for the first time-the selection of infrared-variable and high proper motion objects over a wide field on timescales of years. Because of its large survey volume, SDWFS is sensitive to galaxies out to z ∼ 3 with relatively little impact from cosmic variance for all but the richest systems. The SDWFS data sets will thus be especially useful for characterizing galaxy evolution beyond z ∼ 1.5. This paper explains the SDWFS observing strategy and data processing, presents the SDWFS mosaics and source catalogs, and discusses some early scientific findings. The publicly released, full-depth catalogs contain 6.78, 5.23, 1.20, and 0.96 x 10 5 distinct sources detected to the average 5σ, 4''-diameter, aperture-corrected limits of 19.77, 18.83, 16.50, and 15.82 Vega mag at 3.6, 4.5, 5.8, and 8.0 μm, respectively. The SDWFS number counts and color-color distribution are consistent with other, earlier Spitzer surveys. At the 6 minute integration time of the SDWFS IRAC imaging, >50% of isolated Faint Images of the Radio Sky at Twenty cm radio sources and >80% of on-axis XBooetes sources are detected out to 8.0 μm. Finally, we present the four highest proper motion IRAC-selected sources identified from the multi-epoch imaging, two of which are likely field brown dwarfs of mid-T spectral class.

  5. WIRELESS MINE-WIDE TELECOMMUNICATIONS TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    Zvi H. Meiksin

    2004-03-01

    A comprehensive mine-wide, two-way wireless voice and data communication system for the underground mining industry was developed. The system achieves energy savings through increased productivity and greater energy efficiency in meeting safety requirements within mines. The mine-wide system is comprised of two interfaced subsystems: a through-the-earth communications system and an in-mine communications system. The mine-wide system permits two-way communication among underground personnel and between underground and surface personnel. The system was designed, built, and commercialized. Several systems are in operation in underground mines in the United States. The use of these systems has proven they result in considerable energy savings. A system for tracking the location of vehicles and people within the mine was also developed, built and tested successfully. Transtek's systems are being used by the National Institute of Occupational Safety and Health (NIOSH) in their underground mine rescue team training program. This project also resulted in a spin-off rescue team lifeline and communications system. Furthermore, the project points the way to further developments that can lead to a GPS-like system for underground mines allowing the use of autonomous machines in underground mining operations, greatly reducing the amount of energy used in these operations. Some products developed under this program are transferable to applications in fields other than mining. The rescue team system is applicable to use by first responders to natural, accidental, or terrorist-caused building collapses. The in-mine communications system can be installed in high-rise buildings providing in-building communications to security and maintenance personnel as well as to first responders.

  6. Pickering Nuclear site wide groundwater monitoring system

    International Nuclear Information System (INIS)

    DeWilde, J.; Chin-Cheong, D.; Lledo, C.; Wootton, R.; Belanger, D.; Hansen, K.

    2001-01-01

    Ontario Power Generation Inc. (OPG) is continuing its efforts to understand the chemical and physical characteristics of the groundwater flow systems beneath the Pickering Nuclear Generating Station (PNGS). To this end, OPG constructed a site-wide Groundwater Monitoring System (GMS) at the PNGS to provide support to other ongoing environmental investigations and to provide a means to monitor current and future groundwater environmental issues. This paper will present the results of this work, including the development of a state-of-the-art data management system for storage and retrieval of environmental data for the site, which has applications for other power generation facilities. (author)

  7. Wide Strip Casting Technology of Magnesium Alloys

    Science.gov (United States)

    Park, W.-J.; Kim, J. J.; Kim, I. J.; Choo, D.

    Extensive investigations relating to the production of high performance and low cost magnesium sheet by strip casting have been performed for the application to automotive parts and electronic devices. Research on magnesium sheet production technology started in 2004 by Research Institute of Industrial Science and Technology (RIST) with support of Pohang Iron and Steel Company (POSCO). POSCO has completed the world's first plant to manufacture magnesium coil. Another big project in order to develop wide strip casting technology for the automotive applications of magnesium sheets was started in succession.

  8. FGWAS: Functional genome wide association analysis.

    Science.gov (United States)

    Huang, Chao; Thompson, Paul; Wang, Yalin; Yu, Yang; Zhang, Jingwen; Kong, Dehan; Colen, Rivka R; Knickmeyer, Rebecca C; Zhu, Hongtu

    2017-10-01

    Functional phenotypes (e.g., subcortical surface representation), which commonly arise in imaging genetic studies, have been used to detect putative genes for complexly inherited neuropsychiatric and neurodegenerative disorders. However, existing statistical methods largely ignore the functional features (e.g., functional smoothness and correlation). The aim of this paper is to develop a functional genome-wide association analysis (FGWAS) framework to efficiently carry out whole-genome analyses of functional phenotypes. FGWAS consists of three components: a multivariate varying coefficient model, a global sure independence screening procedure, and a test procedure. Compared with the standard multivariate regression model, the multivariate varying coefficient model explicitly models the functional features of functional phenotypes through the integration of smooth coefficient functions and functional principal component analysis. Statistically, compared with existing methods for genome-wide association studies (GWAS), FGWAS can substantially boost the detection power for discovering important genetic variants influencing brain structure and function. Simulation studies show that FGWAS outperforms existing GWAS methods for searching sparse signals in an extremely large search space, while controlling for the family-wise error rate. We have successfully applied FGWAS to large-scale analysis of data from the Alzheimer's Disease Neuroimaging Initiative for 708 subjects, 30,000 vertices on the left and right hippocampal surfaces, and 501,584 SNPs. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Review of stellarator research world wide

    International Nuclear Information System (INIS)

    Shonet, J.L.

    1987-01-01

    The world-wide effort in stellarators has evolved considerably during the past few years. Stellarator facilities are located in the Australia, Federal Republic of Germany, Japan, the Soviet Union, Spain, the United Kingdom and the United States. Dimensions of stellarators range from less than 20 centimeters in major radius to more than 2 meters, and magnetic field values between 0.2 Tesla to more than 3.0 Tesla. Stellarators are made in a variety of magnetic configurations with wide ranges of toroidal aspect ratios and methods of generating the stellarator magnetic surfaces. In particular, continuous helical coils, twisted modular coils, or twisted vacuum chambers all provide different means to generate nested toroidal magnetic surfaces without the need for currents flowing in the plasma. The goal of present day experiments is to accumulate a physics data base. This is being done by increasing electron and ion temperatures with non-ohmic heating, by transport and scaling studies considering neoclassical scaling, global scaling, effects of electric fields, the bootstrap current and magnetic islands. Higher betas are being attempted by designing suitable magnetic configurations, pellet injection and/or minimizing transport losses. Plasma-wall interactions and particle control are being examined by divertor, pumped-limiter and carbonization experiments

  10. [Wide QRS tachycardia preceded by pacemaker spikes].

    Science.gov (United States)

    Romero, M; Aranda, A; Gómez, F J; Jurado, A

    2014-04-01

    The differential diagnosis and therapeutic management of wide QRS tachycardia preceded by pacemaker spike is presented. The pacemaker-mediated tachycardia, tachycardia fibrillo-flutter in patients with pacemakers, and runaway pacemakers, have a similar surface electrocardiogram, but respond to different therapeutic measures. The tachycardia response to the application of a magnet over the pacemaker could help in the differential diagnosis, and in some cases will be therapeutic, as in the case of a tachycardia-mediated pacemaker. Although these conditions are diagnosed and treated in hospitals with catheterization laboratories using the application programmer over the pacemaker, patients presenting in primary care clinic and emergency forced us to make a diagnosis and treat the haemodynamically unstable patient prior to referral. Copyright © 2012 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  11. Genome-wide Analysis of Gene Regulation

    DEFF Research Database (Denmark)

    Chen, Yun

    to protein: through epigenetic modifications, transcription regulators or post-transcriptional controls. The following papers concern several layers of gene regulation with questions answered by different HTS approaches. Genome-wide screening of epigenetic changes by ChIP-seq allowed us to study both spatial...... and temporal alterations of histone modifications (Papers I and II). Coupling the data with machine learning approaches, we established a prediction framework to assess the most informative histone marks as well as their most influential nucleosome positions in predicting the promoter usages. (Papers I...... they regulated or if the sites had global elevated usage rates by multiple TFs. Using RNA-seq, 5’end-seq in combination with depletion of 5’exonuclease as well as nonsensemediated decay (NMD) factors, we systematically analyzed NMD substrates as well as their degradation intermediates in human cells (Paper V...

  12. World-Wide Web the information universe

    CERN Document Server

    Berners-Lee, Tim; Groff, Jean-Francois; Pollermann, Bernd

    1992-01-01

    Purpose - The World-Wide Web (W-3) initiative is a practical project designed to bring a global information universe into existence using available technology. This paper seeks to describe the aims, data model, and protocols needed to implement the "web" and to compare them with various contemporary systems. Design/methodology/approach - Since Vannevar Bush's article, men have dreamed of extending their intellect by making their collective knowledge available to each individual by using machines. Computers provide us two practical techniques for human-knowledge interface. One is hypertext, in which links between pieces of text (or other media) mimic human association of ideas. The other is text retrieval, which allows associations to be deduced from the content of text. The W-3 ideal world allows both operations and provides access from any browsing platform. Findings - Various server gateways to other information systems have been produced, and the total amount of information available on the web is...

  13. Plant Wide Assessment for SIFCO Industries, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Kelly Kissock, Arvind Thekdi et. al.

    2005-07-06

    Sifco Industries carreid out a plant wide energy assessment under a collaborative program with the U.S. Department of Energy during October 2004 to September 2005. During the year, personnel from EIS, E3M, DPS, BuyCastings.Com, and Sifco plant facilities and maintenance personnel, as a team collected energy use, construction, process, equipment and operational information about the plant. Based on this information, the team identified 13 energy savings opportunities. Near term savings opportunities have a total potential savings of about $1,329,000 per year and a combined simple payback of about 11 months. Implementation of these recommendations would reduce CO2 emissions by about 16,000,000 pounds per year, which would reduce overall plant CO2 emissions by about 45%. These totals do not include another $830,000 per year in potential savings with an estimated 9-month payback, from converting the forging hammers from steam to compressed air.

  14. Wide Angle Michelson Doppler Imaging Interferometer (WAMDII)

    Science.gov (United States)

    Roberts, B.

    1986-01-01

    The wide angle Michelson Doppler imaging interferometer (WAMDII) is a specialized type of optical Michelson interferometer working at sufficiently long path difference to measure Doppler shifts and to infer Doppler line widths of naturally occurring upper atmospheric Gaussian line emissions. The instrument is intended to measure vertical profiles of atmospheric winds and temperatures within the altitude range of 85 km to 300 km. The WAMDII consists of a Michelson interferometer followed by a camera lens and an 85 x 106 charge coupled device photodiode array. Narrow band filters in a filter wheel are used to isolate individual line emissions and the lens forms an image of the emitting region on the charge coupled device array.

  15. Community wide interventions for increasing physical activity.

    Science.gov (United States)

    Baker, Philip R A; Francis, Daniel P; Soares, Jesus; Weightman, Alison L; Foster, Charles

    2015-01-05

    Multi-strategic community wide interventions for physical activity are increasingly popular but their ability to achieve population level improvements is unknown. To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity. We searched the Cochrane Public Health Group Segment of the Cochrane Register of Studies,The Cochrane Library, MEDLINE, MEDLINE in Process, EMBASE, CINAHL, LILACS, PsycINFO, ASSIA, the British Nursing Index, Chinese CNKI databases, EPPI Centre (DoPHER, TRoPHI), ERIC, HMIC, Sociological Abstracts, SPORT Discus, Transport Database and Web of Science (Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index). We also scanned websites of the EU Platform on Diet, Physical Activity and Health; Health-Evidence.org; the International Union for Health Promotion and Education; the NIHR Coordinating Centre for Health Technology (NCCHTA); the US Centre for Disease Control and Prevention (CDC) and NICE and SIGN guidelines. Reference lists of all relevant systematic reviews, guidelines and primary studies were searched and we contacted experts in the field. The searches were updated to 16 January 2014, unrestricted by language or publication status. Cluster randomised controlled trials, randomised controlled trials, quasi-experimental designs which used a control population for comparison, interrupted time-series studies, and prospective controlled cohort studies were included. Only studies with a minimum six-month follow up from the start of the intervention to measurement of outcomes were included. Community wide interventions had to comprise at least two broad strategies aimed at physical activity for the whole population. Studies which randomised individuals from the same community were excluded. At least two review authors independently extracted the data and assessed the risk of bias. Each study was assessed for the setting, the number of included components

  16. Generalization of the Wide-Sense Markov Concept to a Widely Linear Processing

    International Nuclear Information System (INIS)

    Espinosa-Pulido, Juan Antonio; Navarro-Moreno, Jesús; Fernández-Alcalá, Rosa María; Ruiz-Molina, Juan Carlos; Oya-Lechuga, Antonia; Ruiz-Fuentes, Nuria

    2014-01-01

    In this paper we show that the classical definition and the associated characterizations of wide-sense Markov (WSM) signals are not valid for improper complex signals. For that, we propose an extension of the concept of WSM to a widely linear (WL) setting and the study of new characterizations. Specifically, we introduce a new class of signals, called widely linear Markov (WLM) signals, and we analyze some of their properties based either on second-order properties or on state-space models from a WL processing standpoint. The study is performed in both the forwards and backwards directions of time. Thus, we provide two forwards and backwards Markovian representations for WLM signals. Finally, different estimation recursive algorithms are obtained for these models

  17. Traffic Flow Wide-Area Surveillance system

    Energy Technology Data Exchange (ETDEWEB)

    Allgood, G.O.; Ferrell, R.K.; Kercel, S.W.; Abston, R.A.

    1994-09-01

    Traffic management can be thought of as a stochastic queuing process where the serving time at one of its control points is dynamically linked to the global traffic pattern, which is, in turn, dynamically linked to the control point. For this closed-loop system to be effective, the traffic management system must sense and interpret a large spatial projection of data originating from multiple sensor suites. This concept is the basis for the development of a Traffic Flow Wide-Area Surveillance (TFWAS) system. This paper presents the results of a study by Oak Ridge National Laboratory to define the operational specifications and characteristics, to determine the constraints, and to examine the state of technology of a TFWAS system in terms of traffic management and control. In doing so, the functions and attributes of a TFWAS system are mapped into an operational structure consistent with the Intelligent Vehicle Highway System (IVHS) concept and the existing highway infrastructure. This mapping includes identifying candidate sensor suites and establishing criteria, requirements, and performance measures by which these systems can be graded in their ability and practicality to meet the operational requirements of a TFWAS system. In light of this, issues such as system integration, applicable technologies, impact on traffic management and control, and public acceptance are addressed.

  18. Golden Jubilee Photos: World Wide Web

    CERN Multimedia

    2004-01-01

    At the end of the 1980s, the Internet was already a valuable tool to scientists, allowing them to exchange e-mails and to access powerful computers remotely. A more simple means of sharing information was needed, however, and CERN, with its long tradition of informatics and networking, was the ideal place to find it. Moreover, hundreds of scientists from all over the world were starting to work together on preparations for the experiments at the Large Electron-Positron (LEP) collider. In 1989, Tim Berners-Lee (see photo), a young scientist working at CERN, drafted a proposal for an information-management system combining the internet, personal computers and computer-aided document consultation, known as hypertext. In 1990 he was joined by Robert Cailliau and the weaving of the World Wide Web began in earnest, even though only two CERN computers were allocated to the task at the time. The Web subsequently underwent a steady expansion to include the world's main particle physics institutes. The Web was not the...

  19. Bitcoin – the World-Wide Currency

    Directory of Open Access Journals (Sweden)

    Shuba Olena А.

    2017-11-01

    Full Text Available The article is aimed at researching bitcoin, the digital currency. It has been found that Bitcoin is a cryptocurrency, that is, the virtual money, which has no material equivalent. The history of creation and development of cryptocurrency was reviewed. There is a reduction in volatility, which guarantees the security of currency, as well as the increase in currency volume and the inability to estimate the profitability of bitcoins. The dynamics of the value of digital currency in US dollars over recent years has been analyzed. Improvement of attitude of many countries to the considered cryptocurrency, in particular the USA, Germany, Spain, Canada, Australia, Israel and Scandinavian countries has been identified. The reasons of Ukraine’s interest in Bitcoin have been considered. Possibilities of creation of cryptocurrency on the territory of Ukraine have been analyzed, i.e. cost of electricity for mining, the legal status of mining firms, and the attitude of the National Bank of Ukraine to the digital currency. It has been concluded that the recognition of Bitcoin by the world countries in the future will allow it to be granted the status of world-wide currency.

  20. Metasurface Enabled Wide-Angle Fourier Lens.

    Science.gov (United States)

    Liu, Wenwei; Li, Zhancheng; Cheng, Hua; Tang, Chengchun; Li, Junjie; Zhang, Shuang; Chen, Shuqi; Tian, Jianguo

    2018-06-01

    Fourier optics, the principle of using Fourier transformation to understand the functionalities of optical elements, lies at the heart of modern optics, and it has been widely applied to optical information processing, imaging, holography, etc. While a simple thin lens is capable of resolving Fourier components of an arbitrary optical wavefront, its operation is limited to near normal light incidence, i.e., the paraxial approximation, which puts a severe constraint on the resolvable Fourier domain. As a result, high-order Fourier components are lost, resulting in extinction of high-resolution information of an image. Other high numerical aperture Fourier lenses usually suffer from the bulky size and costly designs. Here, a dielectric metasurface consisting of high-aspect-ratio silicon waveguide array is demonstrated experimentally, which is capable of performing 1D Fourier transform for a large incident angle range and a broad operating bandwidth. Thus, the device significantly expands the operational Fourier space, benefitting from the large numerical aperture and negligible angular dispersion at large incident angles. The Fourier metasurface will not only facilitate efficient manipulation of spatial spectrum of free-space optical wavefront, but also be readily integrated into micro-optical platforms due to its compact size. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Community wide interventions for increasing physical activity.

    Science.gov (United States)

    Baker, Philip Ra; Francis, Daniel P; Soares, Jesus; Weightman, Alison L; Foster, Charles

    2011-04-13

    Multi-strategic community wide interventions for physical activity are increasingly popular but their ability to achieve population level improvements is unknown. To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity. We searched the Cochrane Public Health Group Specialised Register, The Cochrane Library, MEDLINE, MEDLINE in Process, EMBASE, CINAHL, LILACS, PsycINFO, ASSIA, The British Nursing Index, Chinese CNKI databases, EPPI Centre (DoPHER, TRoPHI), ERIC, HMIC, Sociological Abstracts, SPORTDiscus, Transport Database and Web of Science (Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index). We also scanned websites of the EU Platform on Diet, Physical Activity and Health; Health-Evidence.ca; the International Union for Health Promotion and Education; the NIHR Coordinating Centre for Health Technology (NCCHTA) and NICE and SIGN guidelines. Reference lists of all relevant systematic reviews, guidelines and primary studies were followed up. We contacted experts in the field from the National Obesity Observatory Oxford, Oxford University; Queensland Health, Queensland University of Technology, the University of Central Queensland; the University of Tennessee and Washington University; and handsearched six relevant journals. The searches were last updated to the end of November 2009 and were not restricted by language or publication status. Cluster randomised controlled trials, randomised controlled trials (RCT), quasi-experimental designs which used a control population for comparison, interrupted time-series (ITS) studies, and prospective controlled cohort studies (PCCS) were included. Only studies with a minimum six-month follow up from the start of the intervention to measurement of outcomes were included. Community wide interventions had to comprise at least two broad strategies aimed at physical activity for the whole population. Studies which randomised

  2. Natural background radiation exposures world-wide

    International Nuclear Information System (INIS)

    Bennett, B.G.

    1993-01-01

    The average radiation dose to the world's population from natural radiation sources has been assessed by UNSCEAR to be 2.4 mSv per year. The components of this exposure, methods of evaluation and, in particular, the variations in the natural background levels are presented in this paper. Exposures to cosmic radiation range from 0.26 mSv per year at sea level to 20 times more at an altitude of 6000 m. Exposures to cosmogenic radionuclides ( 3 H, 14 C) are relatively insignificant and little variable. The terrestrial radionuclides 40 K, 238 U, and 232 Th and the decay products of the latter two constitute the remainder of the natural radiation exposure. Wide variations in exposure occur for these components, particularly for radon and its decay products, which can accumulate to relatively high levels indoors. Unusually high exposures to uranium and thorium series radionuclides characterize the high natural background areas which occur in several localized regions in the world. Extreme values in natural radiation exposures have been estimated to range up to 100 times the average values. (author). 15 refs, 3 tabs

  3. Traffic flow wide-area surveillance system

    Science.gov (United States)

    Allgood, Glenn O.; Ferrell, Regina K.; Kercel, Stephen W.; Abston, Ruth A.

    1995-01-01

    Traffic management can be thought of as a stochastic queuing process where the serving time at one of its control points is dynamically linked to the global traffic pattern, which is, in turn, dynamically linked to the control point. For this closed-loop system to be effective, the traffic management system must sense and interpret a large spatial projection of data originating from multiple sensor suites. This concept is the basis for the development of a traffic flow wide-area surveillance (TFWAS) system. This paper presents the results of a study by Oak Ridge National Laboratory to define the operational specifications and characteristics, to determine the constraints, and to examine the state of technology of a TFWAS system in terms of traffic management and control. In doing so, the functions and attributes of a TFWAS system are mapped into an operational structure consistent with the Intelligent Vehicle Highway System (IVHS) concept and the existing highway infrastructure. This mapping includes identifying candidate sensor suites and establishing criteria, requirements, and performance measures by which these systems can be graded in their ability and practicality to meet the operational requirements of a TFWAS system. In light of this, issues such as system integration, applicable technologies, impact on traffic management and control, and public acceptance are addressed.

  4. World Wide Web of Your Wide Web? Juridische aspecten van zoekmachine-personalisatie

    NARCIS (Netherlands)

    Oostveen, M.

    2012-01-01

    Het world wide web is een enorme bron van informatie. Iedere internetgebruiker maakt gebruik van zoekmachines om die informatie te kunnen vinden. Veel gebruikers weten echter niet dat zoekresultaten behorende bij een bepaalde zoekterm niet voor iedereen hetzelfde zijn. Dit personaliseren van

  5. The Wide Field Imager instrument for Athena

    Science.gov (United States)

    Meidinger, Norbert; Barbera, Marco; Emberger, Valentin; Fürmetz, Maria; Manhart, Markus; Müller-Seidlitz, Johannes; Nandra, Kirpal; Plattner, Markus; Rau, Arne; Treberspurg, Wolfgang

    2017-08-01

    ESA's next large X-ray mission ATHENA is designed to address the Cosmic Vision science theme 'The Hot and Energetic Universe'. It will provide answers to the two key astrophysical questions how does ordinary matter assemble into the large-scale structures we see today and how do black holes grow and shape the Universe. The ATHENA spacecraft will be equipped with two focal plane cameras, a Wide Field Imager (WFI) and an X-ray Integral Field Unit (X-IFU). The WFI instrument is optimized for state-of-the-art resolution spectroscopy over a large field of view of 40 amin x 40 amin and high count rates up to and beyond 1 Crab source intensity. The cryogenic X-IFU camera is designed for high-spectral resolution imaging. Both cameras share alternately a mirror system based on silicon pore optics with a focal length of 12 m and large effective area of about 2 m2 at an energy of 1 keV. Although the mission is still in phase A, i.e. studying the feasibility and developing the necessary technology, the definition and development of the instrumentation made already significant progress. The herein described WFI focal plane camera covers the energy band from 0.2 keV to 15 keV with 450 μm thick fully depleted back-illuminated silicon active pixel sensors of DEPFET type. The spatial resolution will be provided by one million pixels, each with a size of 130 μm x 130 μm. The time resolution requirement for the WFI large detector array is 5 ms and for the WFI fast detector 80 μs. The large effective area of the mirror system will be completed by a high quantum efficiency above 90% for medium and higher energies. The status of the various WFI subsystems to achieve this performance will be described and recent changes will be explained here.

  6. Genome wide selection in Citrus breeding.

    Science.gov (United States)

    Gois, I B; Borém, A; Cristofani-Yaly, M; de Resende, M D V; Azevedo, C F; Bastianel, M; Novelli, V M; Machado, M A

    2016-10-17

    Genome wide selection (GWS) is essential for the genetic improvement of perennial species such as Citrus because of its ability to increase gain per unit time and to enable the efficient selection of characteristics with low heritability. This study assessed GWS efficiency in a population of Citrus and compared it with selection based on phenotypic data. A total of 180 individual trees from a cross between Pera sweet orange (Citrus sinensis Osbeck) and Murcott tangor (Citrus sinensis Osbeck x Citrus reticulata Blanco) were evaluated for 10 characteristics related to fruit quality. The hybrids were genotyped using 5287 DArT_seq TM (diversity arrays technology) molecular markers and their effects on phenotypes were predicted using the random regression - best linear unbiased predictor (rr-BLUP) method. The predictive ability, prediction bias, and accuracy of GWS were estimated to verify its effectiveness for phenotype prediction. The proportion of genetic variance explained by the markers was also computed. The heritability of the traits, as determined by markers, was 16-28%. The predictive ability of these markers ranged from 0.53 to 0.64, and the regression coefficients between predicted and observed phenotypes were close to unity. Over 35% of the genetic variance was accounted for by the markers. Accuracy estimates with GWS were lower than those obtained by phenotypic analysis; however, GWS was superior in terms of genetic gain per unit time. Thus, GWS may be useful for Citrus breeding as it can predict phenotypes early and accurately, and reduce the length of the selection cycle. This study demonstrates the feasibility of genomic selection in Citrus.

  7. Wide Bandgap Semiconductor Opportunities in Power Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Das, Sujit [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Marlino, Laura D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Armstrong, Kristina O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2018-01-01

    The report objective is to explore the Wide Bandgap (WBG) Power Electronics (PE) market, applications, and potential energy savings in order to identify key areas where further resources and investments of the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE EERE) would have the most impact on U.S. competiveness. After considering the current market, several potential near-term application areas were identified as having significant market and energy savings potential with respect to clean energy applications: (1) data centers (uninterruptible power supplies and server power supplies); (2) renewable energy generation (photovoltaic-solar and wind); (3) motor drives (industrial, commercial and residential); (4) rail traction; and, (5) hybrid and electric vehicles (traction and charging). After the initial explorative analyses, it became clear that, SiC, not GaN, would be the principal WBG power device material for the chosen markets in the near future. Therefore, while GaN is discussed when appropriate, this report focuses on SiC devices, other WBG applications (e.g., solid-state transformers, combined heat and power, medical, and wireless power), the GaN market, and GaN specific applications (e.g., LiDAR, 5G) will be explored at a later date. In addition to the market, supply and value chain analyses addressed in Section 1 of this report, a SWOT (Strength, Weakness, Opportunity, Threat) analysis and potential energy savings analysis was conducted for each application area to identify the major potential WBG application area(s) with a U.S. competitiveness opportunity in the future.

  8. Real Time Wide Area Radiation Surveillance System

    Science.gov (United States)

    Biafore, M.

    2012-04-01

    We present the REWARD project, financed within the FP7 programme, theme SEC-2011.1.5-1 (Development of detection capabilities of difficult to detect radioactive sources and nuclear materials - Capability Project). Within this project, we propose a novel mobile system for real time, wide area radiation surveillance. The system is based on the integration of new miniaturized solid-state radiation sensors: a CdZnTe detector for gamma radiation and a high efficiency neutron detector based on novel silicon technologies. The sensing unit will include a wireless communication interface to send the data remotely to a monitoring base station which also uses a GPS system to calculate the position of the tag. The system will also incorporate middleware and high level software to provide web-service interfaces for the exchange of information, and that will offer top level functionalities as management of users, mobile tags and environment data and alarms, database storage and management and a web-based graphical user interface. Effort will be spent to ensure that the software is modular and re-usable across as many architectural levels as possible. Finally, an expert system will continuously analyze the information from the radiation sensor and correlate it with historical data from the tag location in order to generate an alarm when an abnormal situation is detected. The system will be useful for many different scenarios, including such lost radioactive sources and radioactive contamination. It will be possible to deploy in emergency units and in general in any type of mobile or static equipment. The sensing units will be highly portable thanks to their low size and low energy consumption. The complete system will be scalable in terms of complexity and cost and will offer very high precision on both the measurement and the location of the radiation. The modularity and flexibility of the system will allow for a realistic introduction to the market. Authorities may start with a

  9. Camera Trajectory fromWide Baseline Images

    Science.gov (United States)

    Havlena, M.; Torii, A.; Pajdla, T.

    2008-09-01

    angle θ of its corresponding rays w.r.t. the optical axis as θ = ar 1+br2 . After a successful calibration, we know the correspondence of the image points to the 3D optical rays in the coordinate system of the camera. The following steps aim at finding the transformation between the camera and the world coordinate systems, i.e. the pose of the camera in the 3D world, using 2D image matches. For computing 3D structure, we construct a set of tentative matches detecting different affine covariant feature regions including MSER, Harris Affine, and Hessian Affine in acquired images. These features are alternative to popular SIFT features and work comparably in our situation. Parameters of the detectors are chosen to limit the number of regions to 1-2 thousands per image. The detected regions are assigned local affine frames (LAF) and transformed into standard positions w.r.t. their LAFs. Discrete Cosine Descriptors are computed for each region in the standard position. Finally, mutual distances of all regions in one image and all regions in the other image are computed as the Euclidean distances of their descriptors and tentative matches are constructed by selecting the mutually closest pairs. Opposed to the methods using short baseline images, simpler image features which are not affine covariant cannot be used because the view point can change a lot between consecutive frames. Furthermore, feature matching has to be performed on the whole frame because no assumptions on the proximity of the consecutive projections can be made for wide baseline images. This is making the feature detection, description, and matching much more time-consuming than it is for short baseline images and limits the usage to low frame rate sequences when operating in real-time. Robust 3D structure can be computed by RANSAC which searches for the largest subset of the set of tentative matches which is, within a predefined threshold ", consistent with an epipolar geometry. We use ordered sampling as

  10. Wide Band and Wide Azimuth Beam Effect on High-resolution Synthetic Aperture Radar Radiometric Calibration

    Directory of Open Access Journals (Sweden)

    Hong Jun

    2015-06-01

    Full Text Available Passive corner reflectors and active transponders are often used as man-made reference targets in Synthetic Aperture Radar (SAR radiometric calibration, With the emergence of new radar systems and the increasing demand for greater accuracy, wide-band and wide-beam radars challenge the hypothesis that the Radar Cross Section (RCS of reference targets is constant. In this study, the FEKO electromagnetic simulation software is used to obtain the change curve of the target RCS as a function of frequency and aspect angle while incorporating high-resolution point-target SAR simulation, and quantitatively analyzing the effect of the modulation effect on SAR images. The simulation results suggest that the abovementioned factors affect the SAR calibration by more than 0.2 dB within a fractional bandwidth greater than 10% or azimuth beam width of more than 20°, which must be corrected in the data processing.

  11. World Wide Web voted most wonderful wonder by web-wide world

    CERN Multimedia

    2007-01-01

    The results are in, and the winner is...the World Wide Web! An online survey conducted by the CNN news group ranks the World Wide Web-invented at CERN--as the most wonderful of the seven modern wonders of the world. (See Bulletin No. 49/2006.) There is currently no speculation about whether they would have had the same results had they distributed the survey by post. The World Wide Web won with a whopping 50 per cent of the votes (3,665 votes). The runner up was CERN again, with 16 per cent of voters (1130 votes) casting the ballot in favour of the CERN particle accelerator. Stepping into place behind CERN and CERN is 'None of the Above' with 8 per cent of the votes (611 votes), followed by the development of Dubai (7%), the bionic arm (7%), China's Three Gorges Damn (5%), The Channel Tunnel (4%), and France's Millau viaduct (3%). Thanks to everyone from CERN who voted. You can view the results on http://edition.cnn.com/SPECIALS/2006/modern.wonders/

  12. Genome-Wide Mutagenesis in Borrelia burgdorferi.

    Science.gov (United States)

    Lin, Tao; Gao, Lihui

    2018-01-01

    population of mutants with different tags, after recovered from different tissues of infected mice and ticks, mutants from output pool and input pool are detected using high-throughput, semi-quantitative Luminex ® FLEXMAP™ or next-generation sequencing (Tn-seq) technologies. Thus far, we have created a high-density, sequence-defined transposon library of over 6600 STM mutants for the efficient genome-wide investigation of genes and gene products required for wild-type pathogenesis, host-pathogen interactions, in vitro growth, in vivo survival, physiology, morphology, chemotaxis, motility, structure, metabolism, gene regulation, plasmid maintenance and replication, etc. The insertion sites of 4480 transposon mutants have been determined. About 800 predicted protein-encoding genes in the genome were disrupted in the STM transposon library. The infectivity and some functions of 800 mutants in 500 genes have been determined. Analysis of these transposon mutants has yielded valuable information regarding the genes and gene products important in the pathogenesis and biology of B. burgdorferi and its tick vectors.

  13. Contracting Data Analysis: Assessment of Government-Wide Trends

    Science.gov (United States)

    2017-03-01

    CONTRACTING DATA ANALYSIS Assessment of Government -wide Trends Report to Congressional Addressees March 2017...Office Highlights of GAO-17-244SP, a report to congressional addressees March 2017 CONTRACTING DATA ANALYSIS Assessment of Government -wide...Trends What GAO Found GAO’s analysis of government -wide contracting data found that while defense obligations to buy products and services

  14. Wide and ultra-wide bandgap oxides: where paradigm-shift photovoltaics meets transparent power electronics

    Science.gov (United States)

    Pérez-Tomás, Amador; Chikoidze, Ekaterine; Jennings, Michael R.; Russell, Stephen A. O.; Teherani, Ferechteh H.; Bove, Philippe; Sandana, Eric V.; Rogers, David J.

    2018-03-01

    Oxides represent the largest family of wide bandgap (WBG) semiconductors and also offer a huge potential range of complementary magnetic and electronic properties, such as ferromagnetism, ferroelectricity, antiferroelectricity and high-temperature superconductivity. Here, we review our integration of WBG and ultra WBG semiconductor oxides into different solar cells architectures where they have the role of transparent conductive electrodes and/or barriers bringing unique functionalities into the structure such above bandgap voltages or switchable interfaces. We also give an overview of the state-of-the-art and perspectives for the emerging semiconductor β- Ga2O3, which is widely forecast to herald the next generation of power electronic converters because of the combination of an UWBG with the capacity to conduct electricity. This opens unprecedented possibilities for the monolithic integration in solar cells of both self-powered logic and power electronics functionalities. Therefore, WBG and UWBG oxides have enormous promise to become key enabling technologies for the zero emissions smart integration of the internet of things.

  15. Review of wide band-gap semiconductors technology

    Directory of Open Access Journals (Sweden)

    Jin Haiwei

    2016-01-01

    Full Text Available Silicon carbide (SiC and gallium nitride (GaN are typical representative of the wide band-gap semiconductor material, which is also known as third-generation semiconductor materials. Compared with the conventional semiconductor silicon (Si or gallium arsenide (GaAs, wide band-gap semiconductor has the wide band gap, high saturated drift velocity, high critical breakdown field and other advantages; it is a highly desirable semiconductor material applied under the case of high-power, high-temperature, high-frequency, anti-radiation environment. These advantages of wide band-gap devices make them a hot spot of semiconductor technology research in various countries. This article describes the research agenda of United States and European in this area, focusing on the recent developments of the wide band-gap technology in the US and Europe, summed up the facing challenge of the wide band-gap technology.

  16. Fast neutron dosimeter with wide base silicon diode

    International Nuclear Information System (INIS)

    Ma Lu

    1986-01-01

    This paper briefly introduces a wide base silicon diode fast neutron dosimeter with wide measuring range and good energy response to fast neutron. It is suitable to be used to detect fast neutrons in the mixed field of γ-ray, thermal neutrons and fast neutrons

  17. Use of World Wide Web and NCSA Mcsaic at Langley

    Science.gov (United States)

    Nelson, Michael

    1994-01-01

    A brief history of the use of the World Wide Web at Langley Research Center is presented along with architecture of the Langley Web. Benefits derived from the Web and some Langley projects that have employed the World Wide Web are discussed.

  18. Basic support for cooperative work on the World Wide Web

    NARCIS (Netherlands)

    Bentley, R.; Appelt, W.; Busbach, U.; Hinrichs, E.; Kerr, D.; Sikkel, Nicolaas; Trevor, J.; Woetzel, G.

    The emergence and widespread adoption of the World Wide Web offers a great deal of potential in supporting cross-platform cooperative work within widely dispersed working groups. The Basic Support for Cooperative Work (BSCW) project at GMD is attempting to realize this potential through development

  19. Michelson wide-field stellar interferometry : Principles and experimental verification

    NARCIS (Netherlands)

    Montilla, I.; Pereira, S.F.; Braat, J.J.M.

    2005-01-01

    A new interferometric technique for Michelson wide-field interferometry is presented that consists of a Michelson pupil-plane combination scheme in which a wide field of view can be achieved in one shot. This technique uses a stair-shaped mirror in the intermediate image plane of each telescope in

  20. Database Support for Workflow Management: The WIDE Project

    NARCIS (Netherlands)

    Grefen, P.W.P.J.; Pernici, B; Sánchez, G.; Unknown, [Unknown

    1999-01-01

    Database Support for Workflow Management: The WIDE Project presents the results of the ESPRIT WIDE project on advanced database support for workflow management. The book discusses the state of the art in combining database management and workflow management technology, especially in the areas of

  1. A Design of Wide Band and Wide Beam Cavity-Backed Slot Antenna Array with Slant Polarization

    Directory of Open Access Journals (Sweden)

    Huiying Qi

    2016-01-01

    Full Text Available Design of antenna array under the limitation of restricted size is a challenging problem. Cavity-backed slot antenna is widely used because of its advantages of small size, wide band, and wide beam. In this paper, a design of wide band and wide beam cavity-backed slot antenna array with the slant polarization is proposed. To obtain wide band and wide beam with limited size, the inverted microstrip-fed cavity-backed slot antenna (IMF-CBSA is adopted as the element of 1 × 4 antenna array. The slant polarized antennas and their feeding networks are adopted because of their simple structures. The performance of the proposed antenna array is verified by the simulations and experiments. The measured VSWR < 2 bandwidth is 55% at the center frequency 21.8 GHz, and the gain is larger than 12.2 dB. Experimental results demonstrate that the proposed design achieves wide band and beam with the size of 68 mm × 56 mm × 14.5 mm.

  2. A Wide Spectral Range Reflectance and Luminescence Imaging System

    Directory of Open Access Journals (Sweden)

    Tapani Hirvonen

    2013-10-01

    Full Text Available In this study, we introduce a wide spectral range (200–2500 nm imaging system with a 250 μm minimum spatial resolution, which can be freely modified for a wide range of resolutions and measurement geometries. The system has been tested for reflectance and luminescence measurements, but can also be customized for transmittance measurements. This study includes the performance results of the developed system, as well as examples of spectral images. Discussion of the system relates it to existing systems and methods. The wide range spectral imaging system that has been developed is however highly customizable and has great potential in many practical applications.

  3. Integrated wide-band low-background amplifiers

    International Nuclear Information System (INIS)

    Il'yushchenko, I.I.

    1980-01-01

    Ways of increasing stability and reproduction of characteristics of wide-band integral amplifiers that would to the least extent increase their background noises, are discussed. Considered are some certain flowsheets of integral wide-band amplifiers with low background noise of foreign production which differ from one another by construction of inlet cascades as well as by the applied feedback type. The principal flowsheets of the amplifiers and their main performances are presented. The analysis of the data obtained has revealed that microcircuits made of cascades with a common emitter and local combined feedback are most wide-band among all the considered microcircuits [ru

  4. Wide-band slow-wave systems simulation and applications

    CERN Document Server

    Staras, Stanislovas

    2012-01-01

    The field of electromagnetics has seen considerable advances in recent years, based on the wide applications of numerical methods for investigating electromagnetic fields, microwaves, and other devices. Wide-Band Slow-Wave Systems: Simulation and Applications presents new technical solutions and research results for the analysis, synthesis, and design of slow-wave structures for modern electronic devices with super-wide pass-bands. It makes available, for the first time in English, significant research from the past 20 years that was previously published only in Russian and Lithuanian. The aut

  5. Ultra-low-energy wide electron exposure unit

    International Nuclear Information System (INIS)

    Yonago, Akinobu; Oono, Yukihiko; Tokunaga, Kazutoshi; Kishimoto, Junichi; Wakamoto, Ikuo

    2001-01-01

    Heat and ultraviolet ray processes are used in surface dryness of paint, surface treatment of construction materials and surface sterilization of food containers. A process using a low-energy wide-area electron beam (EB) has been developed that features high speed and low drive cost. EB processing is not widespread in general industry, however, due to high equipment cost and difficult maintenance. We developed an ultra-low-energy wide-area electron beam exposure unit, the Mitsubishi Wide Electron Exposure Unit (MIWEL) to solve these problems. (author)

  6. A simple three dimensional wide-angle beam propagation method

    Science.gov (United States)

    Ma, Changbao; van Keuren, Edward

    2006-05-01

    The development of three dimensional (3-D) waveguide structures for chip scale planar lightwave circuits (PLCs) is hampered by the lack of effective 3-D wide-angle (WA) beam propagation methods (BPMs). We present a simple 3-D wide-angle beam propagation method (WA-BPM) using Hoekstra’s scheme along with a new 3-D wave equation splitting method. The applicability, accuracy and effectiveness of our method are demonstrated by applying it to simulations of wide-angle beam propagation and comparing them with analytical solutions.

  7. Soil Compressibility Models for a Wide Stress Range

    KAUST Repository

    Chong, Song-Hun; Santamarina, Carlos

    2016-01-01

    Soil compressibility models with physically correct asymptotic void ratios are required to analyze situations that involve a wide stress range. Previously suggested models and other functions are adapted to satisfy asymptotic void ratios at low

  8. A micro-controller based wide range survey meter

    International Nuclear Information System (INIS)

    Bhingare, R.R.; Bajaj, K.C.; Kannan, S.

    2004-01-01

    Wide range survey meters (1μSv/h -10 Sv/h) with the detector(s) mounted at the end of a two-to-four meter-long extendable tube are widely used for radiation protection survey of difficult to reach locations and high dose rate areas, The commercially available survey meters of this type use two GM counters to cover a wide range of dose rate measurement. A new micro-controller based wide range survey meter using two Si diode detectors has been developed. The use of solid state detectors in the survey meter has a number of advantages like low power consumption, lighter battery powered detector probe, elimination of high voltage for the operation of the detectors, etc. The design uses infrared communication between the probe and the readout unit through a light-weight collapsible extension tube for high reliability. The design details and features are discussed in detail. (author)

  9. Detection of plane, poorly oriented wide flaws using focused transducers

    International Nuclear Information System (INIS)

    Vadder, D. de; Azou, P.; Bastien, P.; Saglio, R.

    1976-01-01

    The detection of plane, poorly oriented, wide flaws by ultrasonic non destructive testing is distinctly improved when using focused transducers. An increased echo can be obtained crossing the defect limit [fr

  10. Informal science education: lifelong, life-wide, life-deep.

    Science.gov (United States)

    Sacco, Kalie; Falk, John H; Bell, James

    2014-11-01

    Informal Science Education: Lifelong, Life-Wide, Life-Deep Informal science education cultivates diverse opportunities for lifelong learning outside of formal K-16 classroom settings, from museums to online media, often with the help of practicing scientists.

  11. Seattle wide-area information for travelers (SWIFT) : architecture study

    Science.gov (United States)

    1998-10-19

    The SWIFT (Seattle Wide-area Information For Travelers) Field Operational Test was intended to evaluate the performance of a large-scale urban Advanced Traveler Information System (ATIS) deployment in the Seattle area. The unique features of the SWIF...

  12. Distributing Congestion Management System Information Using the World Wide Web

    Science.gov (United States)

    1997-01-01

    The Internet is a unique medium for the distribution of information, and it provides a tremendous opportunity to take advantage of peoples innate interest in transportation issues as they relate to their own lives. In particular, the World Wide Web (...

  13. Panchromatic cooperative hyperspectral adaptive wide band deletion repair method

    Science.gov (United States)

    Jiang, Bitao; Shi, Chunyu

    2018-02-01

    In the hyperspectral data, the phenomenon of stripe deletion often occurs, which seriously affects the efficiency and accuracy of data analysis and application. Narrow band deletion can be directly repaired by interpolation, and this method is not ideal for wide band deletion repair. In this paper, an adaptive spectral wide band missing restoration method based on panchromatic information is proposed, and the effectiveness of the algorithm is verified by experiments.

  14. Genome-wide association study of multiplex schizophrenia pedigrees

    DEFF Research Database (Denmark)

    Levinson, Douglas F; Shi, Jianxin; Wang, Kai

    2012-01-01

    The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).......The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)....

  15. Security Analysis of a Software Defined Wide Area Network Solution

    OpenAIRE

    Rajendran, Ashok

    2016-01-01

    Enterprise wide area network (WAN) is a private network that connects the computers and other devices across an organisation's branch locations and the data centers. It forms the backbone of enterprise communication. Currently, multiprotocol label switching (MPLS) is commonly used to provide this service. As a recent alternative to MPLS, software-dened wide area networking (SD-WAN) solutions are being introduced as an IP based cloud-networking service for enterprises. SD-WAN virtualizes the n...

  16. U.S. Geological Survey World Wide Web Information

    Science.gov (United States)

    ,

    2003-01-01

    The U.S. Geological Survey (USGS) invites you to explore an earth science virtual library of digital information, publications, and data. The USGS World Wide Web sites offer an array of information that reflects scientific research and monitoring programs conducted in the areas of natural hazards, environmental resources, and cartography. This list provides gateways to access a cross section of the digital information on the USGS World Wide Web sites.

  17. Genome-wide association study of clinical dimensions of schizophrenia

    DEFF Research Database (Denmark)

    Fanous, Ayman H; Zhou, Baiyu; Aggen, Steven H

    2012-01-01

    Multiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia.......Multiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia....

  18. Wide color gamut display with white and emerald backlighting.

    Science.gov (United States)

    Duan, Lvyin; Lei, Zhichun

    2018-02-20

    This paper proposes a wide color gamut approach that uses white and emerald lighting units as the backlight of the liquid crystal display. The white and emerald backlights are controlled by the image to be displayed. The mixing ratio of the white and the emerald lighting is analyzed so that the maximal color gamut coverage ratio can be achieved. Experimental results prove the effectiveness of the wide color gamut approach using white and emerald backlights.

  19. WorldWideScience.org: Bringing Light to Grey

    OpenAIRE

    Hitson, Brian A. (OSTI-DOE); Johnson, Lorrie A. (OSTI-DOE); GreyNet, Grey Literature Network Service

    2008-01-01

    WorldWideScience.org and its governance structure, the WorldWideScience Alliance, are putting a brighter spotlight on grey literature. Through this new tool, grey literature is getting broader exposure to audiences all over the world. Improved access to and sharing of research information is the key to accelerating progress and breakthroughs in any field, especially science. Includes: Conference preprint, Powerpoint presentation, Abstract and Biographical notes, Pratt student commentary ...

  20. A Genome-Wide Breast Cancer Scan in African Americans

    Science.gov (United States)

    2010-06-01

    SNPs from the African American breast cancer scan to COGs , a European collaborative study which is has designed a SNP array with that will be genotyped...Award Number: W81XWH-08-1-0383 TITLE: A Genome-wide Breast Cancer Scan in African Americans PRINCIPAL INVESTIGATOR: Christopher A...SUBTITLE A Genome-wide Breast Cancer Scan in African Americans 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-08-1-0383 5c. PROGRAM

  1. GWAMA: software for genome-wide association meta-analysis

    Directory of Open Access Journals (Sweden)

    Mägi Reedik

    2010-05-01

    Full Text Available Abstract Background Despite the recent success of genome-wide association studies in identifying novel loci contributing effects to complex human traits, such as type 2 diabetes and obesity, much of the genetic component of variation in these phenotypes remains unexplained. One way to improving power to detect further novel loci is through meta-analysis of studies from the same population, increasing the sample size over any individual study. Although statistical software analysis packages incorporate routines for meta-analysis, they are ill equipped to meet the challenges of the scale and complexity of data generated in genome-wide association studies. Results We have developed flexible, open-source software for the meta-analysis of genome-wide association studies. The software incorporates a variety of error trapping facilities, and provides a range of meta-analysis summary statistics. The software is distributed with scripts that allow simple formatting of files containing the results of each association study and generate graphical summaries of genome-wide meta-analysis results. Conclusions The GWAMA (Genome-Wide Association Meta-Analysis software has been developed to perform meta-analysis of summary statistics generated from genome-wide association studies of dichotomous phenotypes or quantitative traits. Software with source files, documentation and example data files are freely available online at http://www.well.ox.ac.uk/GWAMA.

  2. High-Temperature Electronics: A Role for Wide Bandgap Semiconductors?

    Science.gov (United States)

    Neudeck, Philip G.; Okojie, Robert S.; Chen, Liang-Yu

    2002-01-01

    It is increasingly recognized that semiconductor based electronics that can function at ambient temperatures higher than 150 C without external cooling could greatly benefit a variety of important applications, especially-in the automotive, aerospace, and energy production industries. The fact that wide bandgap semiconductors are capable of electronic functionality at much higher temperatures than silicon has partially fueled their development, particularly in the case of SiC. It appears unlikely that wide bandgap semiconductor devices will find much use in low-power transistor applications until the ambient temperature exceeds approximately 300 C, as commercially available silicon and silicon-on-insulator technologies are already satisfying requirements for digital and analog very large scale integrated circuits in this temperature range. However, practical operation of silicon power devices at ambient temperatures above 200 C appears problematic, as self-heating at higher power levels results in high internal junction temperatures and leakages. Thus, most electronic subsystems that simultaneously require high-temperature and high-power operation will necessarily be realized using wide bandgap devices, once the technology for realizing these devices become sufficiently developed that they become widely available. Technological challenges impeding the realization of beneficial wide bandgap high ambient temperature electronics, including material growth, contacts, and packaging, are briefly discussed.

  3. Ultra-wide-field imaging in diabetic retinopathy.

    Science.gov (United States)

    Ghasemi Falavarjani, Khalil; Tsui, Irena; Sadda, Srinivas R

    2017-10-01

    Since 1991, 7-field images captured with 30-50 degree cameras in the Early Treatment Diabetic Retinopathy Study were the gold standard for fundus imaging to study diabetic retinopathy. Ultra-wide-field images cover significantly more area (up to 82%) of the fundus and with ocular steering can in many cases image 100% of the fundus ("panretinal"). Recent advances in image analysis of ultra-wide-field imaging allow for precise measurements of the peripheral retinal lesions. There is a growing consensus in the literature that ultra-wide-field imaging improves detection of peripheral lesions in diabetic retinopathy and leads to more accurate classification of the disease. There is discordance among studies, however, on the correlation between peripheral diabetic lesions and diabetic macular edema and optimal management strategies to treat diabetic retinopathy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Chapter 10: Mining genome-wide genetic markers.

    Directory of Open Access Journals (Sweden)

    Xiang Zhang

    Full Text Available Genome-wide association study (GWAS aims to discover genetic factors underlying phenotypic traits. The large number of genetic factors poses both computational and statistical challenges. Various computational approaches have been developed for large scale GWAS. In this chapter, we will discuss several widely used computational approaches in GWAS. The following topics will be covered: (1 An introduction to the background of GWAS. (2 The existing computational approaches that are widely used in GWAS. This will cover single-locus, epistasis detection, and machine learning methods that have been recently developed in biology, statistic, and computer science communities. This part will be the main focus of this chapter. (3 The limitations of current approaches and future directions.

  5. Rethinking economy-wide rebound measures: An unbiased proposal

    International Nuclear Information System (INIS)

    Guerra, Ana-Isabel; Sancho, Ferran

    2010-01-01

    In spite of having been first introduced in the last half of the ninetieth century, the debate about the possible rebound effects from energy efficiency improvements is still an open question in the economic literature. This paper contributes to the existing research on this issue proposing an unbiased measure for economy-wide rebound effects. The novelty of this economy-wide rebound measure stems from the fact that not only actual energy savings but also potential energy savings are quantified under general equilibrium conditions. Our findings indicate that the use of engineering savings instead of general equilibrium potential savings downward biases economy-wide rebound effects and upward-biases backfire effects. The discrepancies between the traditional indicator and our proposed measure are analysed in the context of the Spanish economy.

  6. Estimating System-wide Impacts of Smart Grid Demonstrations

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Kevin P.; Lightner, Eric M.; Fuller, Jason C.

    2015-03-01

    Quantifying the impact of a new technology on a single specific distribution feeder is relatively easy, but it does not provide insight into the complexities and variations of a system-wide deployment. It is the inability to extrapolate system-wide impacts that hinders the deployment of many promising new technologies. This paper presents a method of extrapolating technology impacts, either simulated or from a field demonstration, from a limited number of distribution feeders to a system-wide impact. The size of the system can vary from the service territory of a single utility, to a region, or to an entire country. The paper will include an example analysis using the United States Department of Energy (DOE) funded Smart Grid Investment Grant (SGIG) projects, extrapolating their benefits to a national level.

  7. Architecture and Fault Identification of Wide-area Protection System

    Directory of Open Access Journals (Sweden)

    Yuxue Wang

    2012-09-01

    Full Text Available Wide-area protection system (WAPS is widely studied for the purpose of improvng the performance of conventional backup protection. In this paper, the system architecture of WAPS is proposed and its key technologies are discussed in view of engineering projects. So a mixed structurecentralized-distributed structure which is more suitable for WAPS in limited power grid region, is obtained based on the advantages of the centralized structure and distributed structure. Furthermore, regional distance protection algorithm was taken as an example to illustrate the functions of the constituent units. Faulted components can be detected based on multi-source imformation fuse in the algorithm. And the algorithm cannot only improve the selectivity, the rapidity, and the reliability of relaying protection but also has high fault tolerant capability. A simulation of 220 kV grid systems in Easter Hubei province shows the effectiveness of the wide-area protection system presented by this paper.

  8. A novel statistic for genome-wide interaction analysis.

    Directory of Open Access Journals (Sweden)

    Xuesen Wu

    2010-09-01

    Full Text Available Although great progress in genome-wide association studies (GWAS has been made, the significant SNP associations identified by GWAS account for only a few percent of the genetic variance, leading many to question where and how we can find the missing heritability. There is increasing interest in genome-wide interaction analysis as a possible source of finding heritability unexplained by current GWAS. However, the existing statistics for testing interaction have low power for genome-wide interaction analysis. To meet challenges raised by genome-wide interactional analysis, we have developed a novel statistic for testing interaction between two loci (either linked or unlinked. The null distribution and the type I error rates of the new statistic for testing interaction are validated using simulations. Extensive power studies show that the developed statistic has much higher power to detect interaction than classical logistic regression. The results identified 44 and 211 pairs of SNPs showing significant evidence of interactions with FDR<0.001 and 0.001wide interaction analysis is a valuable tool for finding remaining missing heritability unexplained by the current GWAS, and the developed novel statistic is able to search significant interaction between SNPs across the genome. Real data analysis showed that the results of genome-wide interaction analysis can be replicated in two independent studies.

  9. Interoperation of World-Wide Production e-Science Infrastructures

    CERN Document Server

    Riedel, M; Soddemann, T; Field, L; Navarro, JP; Casey, J; Litmaath, M; Baud, J; Koblitz, B; Catlett, C; Skow, D; Wang, S; Saeki, Y; Sato, H; Matsuoka, S; Geddes, N

    Many production Grid and e-Science infrastructures have begun to offer services to end-users during the past several years with an increasing number of scientific applications that require access to a wide variety of resources and services in multiple Grids. Therefore, the Grid Interoperation Now—Community Group of the Open Grid Forum—organizes and manages interoperation efforts among those production Grid infrastructures to reach the goal of a world-wide Grid vision on a technical level in the near future. This contribution highlights fundamental approaches of the group and discusses open standards in the context of production e-Science infrastructures.

  10. Adiponectin Concentrations: A Genome-wide Association Study

    OpenAIRE

    Jee, Sun Ha; Sull, Jae Woong; Lee, Jong-Eun; Shin, Chol; Park, Jongkeun; Kimm, Heejin; Cho, Eun-Young; Shin, Eun-Soon; Yun, Ji Eun; Park, Ji Wan; Kim, Sang Yeun; Lee, Sun Ju; Jee, Eun Jung; Baik, Inkyung; Kao, Linda

    2010-01-01

    Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP a...

  11. Playing with the internet through world wide web

    International Nuclear Information System (INIS)

    Kim, Seon Tae; Jang, Jin Seok

    1995-07-01

    This book describes how to use the internet with world wide web. It is divided into six chapters, which are Let's go to the internet ocean, the internet in information superhighway are, connecting the world with a telephone wire such as link with the internet cable and telephone modem, internet service providers, text mode connection, Domain and IP address, the principle and use of world wide web ; business, music, fashion, movie and photo, internet news and e-mail, making internet map with web language, and from installation to application of base program such as TCP/IP, SLIP/PPP 3270 Emulator, Finger and NCSA Mosaic.

  12. From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research.

    Science.gov (United States)

    Zhang, Y-P; Zhang, Y-Y; Duan, D D

    2016-01-01

    Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the wide individual variations in fat distribution, degree of fatness or health risks, and genetic variants identified in the genome-wide association studies (GWAS). In this review, we will address this important issue with the introduction of phenome, phenomics, and phenome-wide association study (PheWAS). We will discuss the new paradigm shift from GWAS to PheWAS in obesity research. In the era of precision medicine, phenomics and PheWAS provide the required approaches to better definition and classification of obesity according to the association of obese phenome with their unique molecular makeup, lifestyle, and environmental impact. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Non-uniform sampling and wide range angular spectrum method

    International Nuclear Information System (INIS)

    Kim, Yong-Hae; Byun, Chun-Won; Oh, Himchan; Lee, JaeWon; Pi, Jae-Eun; Heon Kim, Gi; Lee, Myung-Lae; Ryu, Hojun; Chu, Hye-Yong; Hwang, Chi-Sun

    2014-01-01

    A novel method is proposed for simulating free space field propagation from a source plane to a destination plane that is applicable for both small and large propagation distances. The angular spectrum method (ASM) was widely used for simulating near field propagation, but it caused a numerical error when the propagation distance was large because of aliasing due to under sampling. Band limited ASM satisfied the Nyquist condition on sampling by limiting a bandwidth of a propagation field to avoid an aliasing error so that it could extend the applicable propagation distance of the ASM. However, the band limited ASM also made an error due to the decrease of an effective sampling number in a Fourier space when the propagation distance was large. In the proposed wide range ASM, we use a non-uniform sampling in a Fourier space to keep a constant effective sampling number even though the propagation distance is large. As a result, the wide range ASM can produce simulation results with high accuracy for both far and near field propagation. For non-paraxial wave propagation, we applied the wide range ASM to a shifted destination plane as well. (paper)

  14. Economy-wide Impact of Investment in Road Infrastructure in ...

    African Journals Online (AJOL)

    In this study an attempt has been made to examine economy wide impact of investment in road infrastructure using a recursive dynamic CGE model. The study used an updated version of the 2005/06 EDRI Social Accounting Matrix. Simulations with the CGE model confirm that with the increasing availability of road ...

  15. Note: A wide temperature range MOKE system with annealing capability.

    Science.gov (United States)

    Chahil, Narpinder Singh; Mankey, G J

    2017-07-01

    A novel sample stage integrated with a longitudinal MOKE system has been developed for wide temperature range measurements and annealing capabilities in the temperature range 65 K temperatures without adversely affecting the cryostat and minimizes thermal drift in position. In this system the hysteresis loops of magnetic samples can be measured simultaneously while annealing the sample in a magnetic field.

  16. WorldWideScience.org: the global science gateway.

    Science.gov (United States)

    Fitzpatrick, Roberta Bronson

    2009-10-01

    WorldWideScience.org is a Web-based global gateway connecting users to both national and international scientific databases and portals. This column will provide background information on the resource as well as introduce basic searching practices for users.

  17. Sources of Militaria on the World Wide Web | Walker | Scientia ...

    African Journals Online (AJOL)

    Having an interest in military-type topics is one thing, finding information on the web to quench your thirst for knowledge is another. The World Wide Web (WWW) is a universal electronic library that contains millions of web pages. As well as being fun, it is an addictive tool on which to search for information. To prevent hours ...

  18. Reactor Engineering Division Material for World Wide Web Pages

    International Nuclear Information System (INIS)

    1996-01-01

    This document presents the home page of the Reactor Engineering Division of Argonne National Laboratory. This WWW site describes the activities of the Division, an introduction to its wide variety of programs and samples of the results of research by people in the division

  19. a potential source of spurious associations in genome-wide ...

    Indian Academy of Sciences (India)

    2010-04-01

    Apr 1, 2010 ... Genome-wide association studies (GWAS) examine the entire human genome with the goal of identifying genetic variants. (usually single nucleotide polymorphisms (SNPs)) that are associated with phenotypic traits such as disease status and drug response. The discordance of significantly associated ...

  20. Touring the Campus Library from the World Wide Web.

    Science.gov (United States)

    Mosley, Pixey Anne; Xiao, Daniel

    1996-01-01

    The philosophy, design, implementation and evaluation of a World Wide Web-accessible Virtual Library Tour of Texas A & M University's Evans Library is presented. Its design combined technical computer issues and library instruction expertise. The tour can be used to simulate a typical walking tour through the library or heading directly to a…

  1. Plesionika edwardsi (Brandt, 1851) is a marine species of wide ...

    African Journals Online (AJOL)

    spamer

    Plesionika edwardsi (Brandt, 1851) is a marine species of wide distribution at low latitudes. It is known from the Western Pacific (Philippines,. Indonesia), the Western Atlantic (from South. Carolina and North Bahamas to the Gulf of Mexico), the Eastern Atlantic (from North-West Spain to. Sierra Leone, including the ...

  2. The World Wide Web and the Television Generation.

    Science.gov (United States)

    Maddux, Cleborne D.

    1996-01-01

    The hypermedia nature of the World Wide Web may represent a true paradigm shift in telecommunications, but barriers exist to the Web having similar impact on education. Some of today's college students compare the Web with "bad TV"--lengthy pauses, links that result in error messages, and animation and sound clips that are too brief.…

  3. Open-Loop Wide-Bandwidth Phase Modulation Techniques

    Directory of Open Access Journals (Sweden)

    Nitin Nidhi

    2011-01-01

    Full Text Available The ever-increasing growth in the bandwidth of wireless communication channels requires the transmitter to be wide-bandwidth and power-efficient. Polar and outphasing transmitter topologies are two promising candidates for such applications, in future. Both these architectures require a wide-bandwidth phase modulator. Open-loop phase modulation presents a viable solution for achieving wide-bandwidth operation. An overview of prior art and recent approaches for phase modulation is presented in this paper. Phase quantization noise cancellation was recently introduced to lower the out-of-band noise in a digital phase modulator. A detailed analysis on the impact of timing and quantization of the cancellation signal is presented. Noise generated by the transmitter in the receive band frequency poses another challenge for wide-bandwidth transmitter design. Addition of a noise transfer function notch, in a digital phase modulator, to reduce the noise in the receive band during phase modulation is described in this paper.

  4. Mechatronic design exploration for wide format printing systems

    NARCIS (Netherlands)

    Bruijnen, D.J.H.

    2007-01-01

    This work aims at increasing the performance of Wide Format Printing Systems (WFPS) via a mechatronic approach. With increasing performance is meant that one or more of the categories: productivity, print quality, reliability and/or cost of production, is improved without sacrificing one of the

  5. Teaching Critical Evaluation Skills for World Wide Web Resources.

    Science.gov (United States)

    Tate, Marsha; Alexander, Jan

    1996-01-01

    Outlines a lesson plan used by an academic library to evaluate the quality of World Wide Web information. Discusses the traditional evaluation criteria of accuracy, authority, objectivity, currency, and coverage as it applies to the unique characteristics of Web pages: their marketing orientation, variety of information, and instability. The…

  6. An area wide control of fruit flies in Mauritius

    International Nuclear Information System (INIS)

    Sookar, P.; Permalloo, S.; Gungah, B.; Alleck, M.; Seewooruthun, S.I.; Soonnoo, A.R.

    2006-01-01

    An area-wide National Fruit Fly Control Programme (NFFCP) was initiated in 1994, funded by the European Union until 1999 and now fully financed by the Government of Mauritius. The NFFCP targets some 75,000 backyard fruit trees owners mainly. The bait application and male annihilation techniques (BAT e MAT) are currently being applied against the fruit flies attacking fleshy fruits and are targeting selected major fruit growing areas in the north, north-east, central and western parts of the island. Successful control has been achieved using these two techniques as demonstrated by trap catches and fruit samplings. The level of fruit fly damage to fruits has been reduced. Presently, the bait-insecticide mixture is being supplied free of charge to the public. The current status of the area-wide suppression programme is such that continuous use of BAT/MAT is a never ending process and as such is not viable. In this context, a TC project on Feasibility studies for integrated use of sterile insect technique for area wide tephritid fruit fly control.Studies are also being carried out on mass rearing of the peach fruit fly for small scale trials on SIT so as to eventually integrate this control method in our area-wide control programme. (author)

  7. Fracture Analysis of the FAA/NASA Wide Stiffened Panels

    Science.gov (United States)

    Seshadri, B. R.; Newman, J. C., Jr.; Dawicke, D. S.; Young, R. D.

    1999-01-01

    This paper presents the fracture analyses conducted on the FAA/NASA stiffened and unstiffened panels using the STAGS (STructural Analysis of General Shells) code with the critical crack-tip-opening angle (CTOA) fracture criterion. The STAGS code with the "plane-strain" core option was used in all analyses. Previous analyses of wide, flat panels have shown that the high-constraint conditions around a crack front, like plane strain, has to be modeled in order for the critical CTOA fracture criterion to predict wide panel failures from small laboratory tests. In the present study, the critical CTOA value was determined from a wide (unstiffened) panel with anti-buckling guides. The plane-strain core size was estimated from previous fracture analyses and was equal to about the sheet thickness. Rivet flexibility and stiffener failure was based on methods and criteria, like that currently used in industry. STAGS and the CTOA criterion were used to predict load-against-crack extension for the wide panels with a single crack and multiple-site damage cracking at many adjacent rivet holes. Analyses were able to predict stable crack growth and residual strength within a few percent (5%) of stiffened panel tests results but over predicted the buckling failure load on an unstiffened panel with a single crack by 10%.

  8. An area wide control of fruit flies in Mauritius

    Energy Technology Data Exchange (ETDEWEB)

    Sookar, P.; Permalloo, S.; Gungah, B.; Alleck, M.; Seewooruthun, S.I.; Soonnoo, A.R., E-mail: ento@intnet.m, E-mail: moa-entomology@mail.gov.m [Ministry of Agro Industry and Fisheries Reduit, Republic of Mauritius (Mauritius)

    2006-07-01

    An area-wide National Fruit Fly Control Programme (NFFCP) was initiated in 1994, funded by the European Union until 1999 and now fully financed by the Government of Mauritius. The NFFCP targets some 75,000 backyard fruit trees owners mainly. The bait application and male annihilation techniques (BAT e MAT) are currently being applied against the fruit flies attacking fleshy fruits and are targeting selected major fruit growing areas in the north, north-east, central and western parts of the island. Successful control has been achieved using these two techniques as demonstrated by trap catches and fruit samplings. The level of fruit fly damage to fruits has been reduced. Presently, the bait-insecticide mixture is being supplied free of charge to the public. The current status of the area-wide suppression programme is such that continuous use of BAT/MAT is a never ending process and as such is not viable. In this context, a TC project on Feasibility studies for integrated use of sterile insect technique for area wide tephritid fruit fly control.Studies are also being carried out on mass rearing of the peach fruit fly for small scale trials on SIT so as to eventually integrate this control method in our area-wide control programme. (author)

  9. Tim Berners-Lee, World Wide Web inventor

    CERN Multimedia

    1998-01-01

    The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

  10. Genome-wide association study identifies five new schizophrenia loci

    NARCIS (Netherlands)

    Ripke, S.; Sanders, A. R.; Kendler, K. S.; Levinson, D. F.; Sklar, P.; Holmans, P. A.; Lin, D. Y.; Duan, J.; Ophoff, R. A.; Andreassen, O. A.; Scolnick, E.; Cichon, S.; St Clair, D.; Corvin, A.; Gurling, H.; Werge, T.; Rujescu, D.; Blackwood, D. H.; Pato, C. N.; Malhotra, A. K.; Purcell, S.; Dudbridge, F.; Neale, B. M.; Rossin, L.; Visscher, P. M.; Posthuma, D.; Ruderfer, D. M.; Fanous, A.; Stefansson, H.; Steinberg, S.; Mowry, B. J.; Golimbet, V.; de Hert, M.; Jonsson, E. G.; Bitter, I.; Pietilainen, O. P.; Collier, D. A.; Tosato, S.; Agartz, I.; Albus, M.; Alexander, M.; Amdur, R. L.; Amin, F.; Bass, N.; Bergen, S. E.; Black, D. W.; Borglum, A. D.; Brown, M. A.; Bruggeman, R.; Buccola, N. G.; Byerley, W. F.; Cahn, W.; Cantor, R. M.; Carr, V. J.; Catts, S. V.; Choudhury, K.; Cloninger, C. R.; Cormican, P.; Craddock, N.; Danoy, P. A.; Datta, S.; de Haan, L.; Demontis, D.; Dikeos, D.; Djurovic, S.; Donnely, P.; Donohoe, G.; Duong, L.; Dwyer, S.; Fink-Jensen, A.; Freedman, R.; Freimer, N. B.; Friedl, M.; Georgieva, L.; Giegling, I.; Gill, M.; Glenthoj, B.; Godard, S.; Hamshere, M.; Hansen, M.; Hartmann, A. M.; Henskens, F. A.; Hougaard, D. M.; Hultman, C. M.; Ingason, A.; Jablensky, A. V.; Jakobsen, K. D.; Jay, M.; Jurgens, G.; Kahn, R. S.; Keller, M. C.; Kenis, G.; Kenny, E.; Kim, Y.; Kirov, G. K.; Konnerth, H.; Konte, B.; Krabbendam, L.; Krasucki, R.; Lasseter, V. K.; Laurent, C.; Lawrence, J.; Lencz, T.; Lerer, F. B.; Liang, K. Y.; Lichtenstein, P.; Lieberman, J. A.; Linszen, D. H.; Lonnqvist, J.; Loughland, C. M.; Maclean, A. W.; Maher, B. S.; Maier, W.; Mallet, J.; Malloy, P.; Mattheisen, M.; Mattingsdal, M.; McGhee, K. A.; McGrath, J. J.; McIntosh, A.; McLean, D. E.; McQuillin, A.; Melle, I.; Michie, P. T.; Milanova, V.; Morris, D. W.; Mors, O.; Mortensen, P. B.; Moskvina, V.; Muglia, P.; Myin-Germeys, I.; Nertney, D. A.; Nestadt, G.; Nielsen, J.; Nikolov, I.; Nordentoft, M.; Norton, N.; Nothen, M. M.; O'Dushlaine, C. T.; Olincy, A.; Olsen, L.; O'Neill, F. A.; Orntoft, T. F.; Owen, M. J.; Pantelis, C.; Papadimitriou, G.; Pato, M. T.; Peltonen, L.; Petursson, H.; Pickard, B.; Pimm, J.; Pulver, A. E.; Puri, V.; Quested, D.; Quinn, E. M.; Rasmussen, H. B.; Rethelyi, J. M.; Ribble, R.; Rietschel, M.; Riley, B. P.; Ruggeri, M.; Schall, U.; Schulze, T. G.; Schwab, S. G.; Scott, R. J.; Shi, J.; Sigurdsson, E.; Silvermann, J. M.; Spencer, C. C.; Stefansson, K.; Strange, A.; Strengman, E.; Stroup, T. S.; Suvisaari, J.; Terenius, L.; Thirumalai, S.; Thygesen, J. H.; Timm, S.; Toncheva, D.; van den Oord, E.; van Os, J.; van Winkel, R.; Veldink, J.; Walsh, D.; Wang, A. G.; Wiersma, D.; Wildenauer, D. B.; Williams, H. J.; Williams, N. M.; Wormley, B.; Zammit, S.; Sullivan, P. F.; O'Donovan, M. C.; Daly, M. J.; Gejman, P. V.

    2011-01-01

    We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded

  11. The features of modelling semiconductor lasers with a wide contact

    Directory of Open Access Journals (Sweden)

    Rzhanov Alexey

    2017-01-01

    Full Text Available The aspects of calculating the dynamics and statics of powerful semiconductor laser diodes radiation are investigated. It takes into account the main physical mechanisms influencing power, spectral composition, far and near field of laser radiation. It outlines a dynamic distributed model of a semiconductor laser with a wide contact and possible algorithms for its implementation.

  12. The development of area wide traffic management scenarios

    NARCIS (Netherlands)

    Van Zuylen, H.J.; Lu, S.; Li, J.; Yusen, C.

    2014-01-01

    Traffic management in cities with congestion is a big challenge with still unused opportunities. Intersection control is a corner stone but this should be done in an area-wide context. The dominant traffic process on urban roads is the traffic flow on the intersections. Spill back is a most

  13. The Receiver System for the Ooty Wide Field Array

    Indian Academy of Sciences (India)

    The legacy Ooty Radio Telescope (ORT) is being reconfigured as a 264-element synthesis telescope, called the Ooty Wide Field Array (OWFA). Its antenna elements are the contiguous 1.92 m sections of the parabolic cylinder. It will operate in a 38-MHz frequency band centred at 326.5 MHz and will be equipped with a ...

  14. Wide baseline stereo matching based on double topological relationship consistency

    Science.gov (United States)

    Zou, Xiaohong; Liu, Bin; Song, Xiaoxue; Liu, Yang

    2009-07-01

    Stereo matching is one of the most important branches in computer vision. In this paper, an algorithm is proposed for wide-baseline stereo vision matching. Here, a novel scheme is presented called double topological relationship consistency (DCTR). The combination of double topological configuration includes the consistency of first topological relationship (CFTR) and the consistency of second topological relationship (CSTR). It not only sets up a more advanced model on matching, but discards mismatches by iteratively computing the fitness of the feature matches and overcomes many problems of traditional methods depending on the powerful invariance to changes in the scale, rotation or illumination across large view changes and even occlusions. Experimental examples are shown where the two cameras have been located in very different orientations. Also, epipolar geometry can be recovered using RANSAC by far the most widely method adopted possibly. By the method, we can obtain correspondences with high precision on wide baseline matching problems. Finally, the effectiveness and reliability of this method are demonstrated in wide-baseline experiments on the image pairs.

  15. Supporting Parent Engagement in Programme-Wide Behavioural Intervention Implementation

    Science.gov (United States)

    Cummings, Katrina P.

    2017-01-01

    Positive behaviour intervention and support (PBIS) models are evolving as an effective means to promote social and emotional competence among young children and address challenging behaviours. This study was designed to gain insights into parental involvement in programme-wide implementation of the "Pyramid" model. Interviews were…

  16. Electrolytes for Wide Operating Temperature Lithium-Ion Cells

    Science.gov (United States)

    Smart, Marshall C. (Inventor); Bugga, Ratnakumar V. (Inventor)

    2016-01-01

    Provided herein are electrolytes for lithium-ion electrochemical cells, electrochemical cells employing the electrolytes, methods of making the electrochemical cells and methods of using the electrochemical cells over a wide temperature range. Included are electrolyte compositions comprising a lithium salt, a cyclic carbonate, a non-cyclic carbonate, and a linear ester and optionally comprising one or more additives.

  17. Genome-wide linkage analysis for human longevity

    DEFF Research Database (Denmark)

    Beekman, Marian; Blanché, Hélène; Perola, Markus

    2013-01-01

    Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian...

  18. Wikinews interviews World Wide Web co-inventor Robert Cailliau

    CERN Multimedia

    2007-01-01

    "The name Robert Caillau may not ring a bell to the general pbulic, but his invention is the reason why you are reading this: Dr. Cailliau together with his colleague Sir Tim Berners-Lee invented the World Wide Web, making the internet accessible so it could grow from an academic tool to a mass communication medium." (9 pages)

  19. Towards a Wide-coverage Tableau Method for Natural Logic

    NARCIS (Netherlands)

    Abzianidze, Lasha; Murata, Tsuyoshi; Mineshima, Koji; Bekki, Daisuke

    2015-01-01

    The rst step towards a wide-coverage tableau prover for natural logic is presented. We describe an automatized method for obtaining Lambda Logical Forms from surface forms and use this method with an implemented prover to hunt for new tableau rules in textual entailment data sets. The collected

  20. Proposed residual stress model for roller bent wide flange sections

    NARCIS (Netherlands)

    Spoorenberg, R.C.; Snijder, H.H.; Hoenderkamp, J.C.D.

    2011-01-01

    The manufacturing process of structural wide flange steel sections introduces residual stresses in the material. These stresses due to hot-rolling or welding influence the inelastic buckling response of structural steel members and need to be taken into account in the design. Based on experimental

  1. Tim Berners-Lee: inventor de la World Wide Web

    OpenAIRE

    Universidad de Granada. Biblioteca

    2015-01-01

    El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

  2. Plant-wide Control Strategy for Improving Produced Water Treatment

    DEFF Research Database (Denmark)

    Yang, Zhenyu; Pedersen, Simon; Løhndorf, Petar Durdevic

    2016-01-01

    This work focuses on investigation and development of an innovative Produced Water Treatment (PWT) technology for offshore oil & gas production by employing the model-based plant-wide control strategy. The key contributions lie in two folds: (i) the advanced anti-slug analysis and control...

  3. A World Wide Web Region-Based Image Search Engine

    DEFF Research Database (Denmark)

    Kompatsiaris, Ioannis; Triantafyllou, Evangelia; Strintzis, Michael G.

    2001-01-01

    In this paper the development of an intelligent image content-based search engine for the World Wide Web is presented. This system will offer a new form of media representation and access of content available in WWW. Information Web Crawlers continuously traverse the Internet and collect images...

  4. Exposure measuring techniques for wide band mobile radio-communications

    International Nuclear Information System (INIS)

    Trinchero, S.; Benedetto, A.; Anglesio, L.; D'Amore, G.; Trinchero, D.

    2004-01-01

    The paper illustrates the limits and performances of different experimental monitoring techniques, which are applied to digitally modulated radiofrequency electromagnetic fields used for mobile telecommunications. Different experimental set-ups have been developed, verified and applied for the analysis and characterisation of wide band probes and narrow band measuring procedures. (authors)

  5. A multifaceted hospital-wide intervention increases hand hygiene ...

    African Journals Online (AJOL)

    A multifaceted hospital-wide intervention increases hand hygiene compliance. B Patel, H Engelbrecht, H McDonald, V Morris, W Smythe. Abstract. Background. Hand hygiene is an important and basic practice that should be used by all healthcare staff to protect both themselves and their patients against infection.

  6. Genome-wide association study of Tourette's syndrome

    NARCIS (Netherlands)

    Scharf, J. M.; Yu, D.; Mathews, C. A.; Neale, B. M.; Stewart, S. E.; Fagerness, J. A.; Evans, P.; Gamazon, E.; Edlund, C. K.; Service, S. K.; Tikhomirov, A.; Osiecki, L.; Illmann, C.; Pluzhnikov, A.; Konkashbaev, A.; Davis, L. K.; Han, B.; Crane, J.; Moorjani, P.; Crenshaw, A. T.; Parkin, M. A.; Reus, V. I.; Lowe, T. L.; Rangel-Lugo, M.; Chouinard, S.; Dion, Y.; Girard, S.; Cath, D. C.; Smit, J. H.; King, R. A.; Fernandez, T. V.; Leckman, J. F.; Kidd, K. K.; Kidd, J. R.; Pakstis, A. J.; State, M. W.; Herrera, L. D.; Romero, R.; Fournier, E.; Sandor, P.; Barr, C. L.; Phan, N.; Gross-Tsur, V.; Benarroch, F.; Pollak, Y.; Budman, C. L.; Bruun, R. D.; Erenberg, G.; Naarden, A. L.; Hoekstra, P. J.

    2013-01-01

    Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association

  7. World Wide Web Homepages: An Examination of Content and Audience.

    Science.gov (United States)

    Reynolds, Betty; And Others

    This paper shows how the content of a World Wide Web page is selected and how an examination of the intended audience influences content. Examples from the New Mexico Tech (NMT) Library homepage show what sources are selected and what level of detail is appropriate for the intended audience. Six fundamental functions of libraries and information…

  8. Service Learning and Building Community with the World Wide Web

    Science.gov (United States)

    Longan, Michael W.

    2007-01-01

    The geography education literature touts the World Wide Web (Web) as a revolutionary educational tool, yet most accounts ignore its uses for public communication and creative expression. This article argues that students can be producers of content that is of service to local audiences. Drawing inspiration from the community networking movement,…

  9. Introduction to the World Wide Web and Mosaic

    Science.gov (United States)

    Youngblood, Jim

    1994-01-01

    This tutorial provides an introduction to some of the terminology related to the use of the World Wide Web and Mosaic. It is assumed that the user has some prior computer experience. References are included to other sources of additional information.

  10. Contemporary Approaches to Critical Thinking and the World Wide Web

    Science.gov (United States)

    Buffington, Melanie L.

    2007-01-01

    Teaching critical thinking skills is often endorsed as a means to help students develop their abilities to navigate the complex world in which people live and, in addition, as a way to help students succeed in school. Over the past few years, this author explored the idea of teaching critical thinking using the World Wide Web (WWW). She began…

  11. Dissemination of watershed management information through the World Wide Web

    Science.gov (United States)

    Malchus B. Baker; Deborah J. Young

    2000-01-01

    Information and related literature on watershed management practices is sometimes not widely known nor readily accessible. New electronic technologies provide unique tools for disseminating research findings to scientists, educators, land management professionals, and the public. This paper illustrates how the usefulness and accessibility of research information from...

  12. Radar Images of the Earth and the World Wide Web

    Science.gov (United States)

    Chapman, B.; Freeman, A.

    1995-01-01

    A perspective of NASA's Jet Propulsion Laboratory as a center of planetary exploration, and its involvement in studying the earth from space is given. Remote sensing, radar maps, land topography, snow cover properties, vegetation type, biomass content, moisture levels, and ocean data are items discussed related to earth orbiting satellite imaging radar. World Wide Web viewing of this content is discussed.

  13. The Relationship of the World Wide Web to Thinking Skills.

    Science.gov (United States)

    Bradshaw, Amy C.; Bishop, Jeanne L.; Gens, Linda S.; Miller, Sharla L.; Rogers, Martha A.

    2002-01-01

    Discusses use of the World Wide Web in education and its possibilities for developing higher order critical thinking skills to successfully deal with the demands of the future information society. Suggests that teachers need to provide learning environments that are learner-centered, authentic, problem-based, and collaborative. (Contains 61…

  14. Perspectives for Electronic Books in the World Wide Web Age.

    Science.gov (United States)

    Bry, Francois; Kraus, Michael

    2002-01-01

    Discusses the rapid growth of the World Wide Web and the lack of use of electronic books and suggests that specialized contents and device independence can make Web-based books compete with print. Topics include enhancing the hypertext model of XML; client-side adaptation, including browsers and navigation; and semantic modeling. (Author/LRW)

  15. Using the World Wide Web To Teach Francophone Culture.

    Science.gov (United States)

    Beyer, Deborah Berg; Van Ells, Paula Hartwig

    2002-01-01

    Examined use of the World Wide Web to teach Francophone culture. Suggests that bolstering reading comprehension in the foreign language and increased proficiency in navigating the Web are potential secondary benefits gained from the cultural Web-based activities proposed in the study.(Author/VWL)

  16. White Supremacists, Oppositional Culture and the World Wide Web

    Science.gov (United States)

    Adams, Josh; Roscigno, Vincent J.

    2005-01-01

    Over the previous decade, white supremacist organizations have tapped into the ever emerging possibilities offered by the World Wide Web. Drawing from prior sociological work that has examined this medium and its uses by white supremacist organizations, this article advances the understanding of recruitment, identity and action by providing a…

  17. Genome-wide association study identifies five new schizophrenia loci.

    LENUS (Irish Health Repository)

    Ripke, Stephan

    2011-10-01

    We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).

  18. Observing GRBs with the LOFT Wide Field Monitor

    DEFF Research Database (Denmark)

    Brandt, Søren; Hernanz, M.; Feroci, M.

    2013-01-01

    (LAD) with a monitor (WFM) instrument. The WFM is based on the coded mask principle, and 5 camera units will provide coverage of more than 1/3 of the sky. The prime goal of the WFM is to detect transient sources to be observed by the LAD. With its wide...

  19. Genome-wide association studies (GWAS) of adiposity

    DEFF Research Database (Denmark)

    Oskari Kilpeläinen, Tuomas; Ingelsson, Erik

    2016-01-01

    Adiposity is strongly heritable and one of the leading risk factors for type 2 diabetes, cardiovascular disease, cancer, and premature death. In the past 8 years, genome-wide association studies (GWAS) have greatly increased our understanding of the genes and biological pathways that regulate...

  20. Advances in wide bandgap SiC for optoelectronics

    DEFF Research Database (Denmark)

    Ou, Haiyan; Ou, Yiyu; Argyraki, Aikaterini

    2014-01-01

    Silicon carbide (SiC) has played a key role in power electronics thanks to its unique physical properties like wide bandgap, high breakdown field, etc. During the past decade, SiC is also becoming more and more active in optoelectronics thanks to the progress in materials growth and nanofabrication...

  1. Leadership Development: A Lever for System-Wide Educational Change

    Science.gov (United States)

    Naicker, Suraiya R.; Mestry, Raj

    2016-01-01

    The continuous poor performance of South Africa's learners is detrimental to its developing economy. The need for education change prompted two universities to initiate a system-wide change strategy in a poorly performing school district. The leverage for change was leadership development, involving school principals and district officials. The…

  2. Benchmark ultra-cool dwarfs in widely separated binary systems

    Directory of Open Access Journals (Sweden)

    Jones H.R.A.

    2011-07-01

    Full Text Available Ultra-cool dwarfs as wide companions to subgiants, giants, white dwarfs and main sequence stars can be very good benchmark objects, for which we can infer physical properties with minimal reference to theoretical models, through association with the primary stars. We have searched for benchmark ultra-cool dwarfs in widely separated binary systems using SDSS, UKIDSS, and 2MASS. We then estimate spectral types using SDSS spectroscopy and multi-band colors, place constraints on distance, and perform proper motions calculations for all candidates which have sufficient epoch baseline coverage. Analysis of the proper motion and distance constraints show that eight of our ultra-cool dwarfs are members of widely separated binary systems. Another L3.5 dwarf, SDSS 0832, is shown to be a companion to the bright K3 giant η Cancri. Such primaries can provide age and metallicity constraints for any companion objects, yielding excellent benchmark objects. This is the first wide ultra-cool dwarf + giant binary system identified.

  3. Process Support for Cooperative Work on the World Wide Web

    NARCIS (Netherlands)

    Sikkel, Nicolaas; Neumann, Olaf; Sachweh, Sabine

    The World Wide Web is becoming a dominating factor in information technology. Consequently, computer supported cooperative work on the Web has recently drawn a lot of attention. Process Support for Cooperative Work (PSCW) is a Web based system supporting both structured and unstructured forms of

  4. Yoga as a School-Wide Positive Behavior Support

    Science.gov (United States)

    Accardo, Amy L.

    2017-01-01

    A yoga-based school-wide positive behavior support (SWPBS) may provide a foundation for teaching mindfulness and self-regulation in K-12 schools. Here, the use of yoga as a SWPBS was examined through a review of existing literature and interviews of yoga program facilitators. Yoga was reported to be effective as a pedagogical approach, and found…

  5. Surfing the World Wide Web to Education Hot-Spots.

    Science.gov (United States)

    Dyrli, Odvard Egil

    1995-01-01

    Provides a brief explanation of Web browsers and their use, as well as technical information for those considering access to the WWW (World Wide Web). Curriculum resources and addresses to useful Web sites are included. Sidebars show sample searches using Yahoo and Lycos search engines, and a list of recommended Web resources. (JKP)

  6. An Architecture for a Wide Area Distributed System

    NARCIS (Netherlands)

    Homburg, P.; Steen, M.R. van; Tanenbaum, A.S.

    1996-01-01

    Distributed systems provide sharing of resources and information over a computer network. A key design issue that makes these systems attractive is that all aspects related to distribution are transparent to users. Unfortunately, general-purpose wide area distributed systems that allow users to

  7. Starting the Conversation: University-Wide Research Data Management Policy

    Science.gov (United States)

    Erway, Ricky

    2013-01-01

    This call for action addresses the high-level benefits of adopting a university-wide policy regarding research data management. It identifies the various university stakeholders and suggests that the library initiate a conversation among them in order to get buy-in for a proactive, rather than reactive, high-level policy for responsible data…

  8. Doped silicene: Evidence of a wide stability range

    KAUST Repository

    Cheng, Yingchun; Zhu, Zhiyong; Schwingenschlö gl, Udo

    2011-01-01

    to the carrier concentration, it is stable in a wide doping range. The frequencies of the E2g-Γ and A′-K Raman modes can be used to probe the carrier concentration. In addition, the phonon dispersion displays Kohn anomalies at the Γ and K points which are reduced

  9. Interactivity, Information Processing, and Learning on the World Wide Web.

    Science.gov (United States)

    Tremayne, Mark; Dunwoody, Sharon

    2001-01-01

    Examines the role of interactivity in the presentation of science news on the World Wide Web. Proposes and tests a model of interactive information processing that suggests that characteristics of users and Web sites influence interactivity, which influences knowledge acquisition. Describes use of a think-aloud method to study participants' mental…

  10. Collaborative Design of World Wide Web Pages: A Case Study.

    Science.gov (United States)

    Andrew, Paige G; Musser, Linda R.

    1997-01-01

    This case study of the collaborative design of an earth science World Wide Web page at Pennsylvania State University highlights the role of librarians. Discusses the original Web site and links, planning, the intended audience, and redesign and recommended changes; and considers the potential contributions of librarians. (LRW)

  11. 15 CFR 922.163 - Prohibited activities-Sanctuary-wide.

    Science.gov (United States)

    2010-01-01

    ... an exotic species of plant, invertebrate, fish, amphibian, or mammals into the Sanctuary. (8) Damage... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Prohibited activities-Sanctuary-wide... RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys National Marine Sanctuary...

  12. Measurements of 42 Wide CPM Pairs with a CCD

    Science.gov (United States)

    Harshaw, Richard

    2015-11-01

    This paper addresses the use of a Skyris 618C color CCD camera as a means of obtaining data for analysis in the measurement of wide common proper motion stars. The equipment setup is described and data collection procedure outlined. Results of the measures of 42 CPM stars are presented, showing the Skyris is a reliable device for the measurement of double stars.

  13. Additional Surgery after Breast-Conserving Surgery Varies Widely

    Science.gov (United States)

    A study published in the Feb. 1, 2012, issue of JAMA found that the number of women who have one or more additional surgeries to remove suspected residual tumor tissue (re-excisions) following breast-conserving surgery (BCS) for breast cancer varies widely across surgeons and hospitals.

  14. Traffic flow wide-area surveillance system definition

    Energy Technology Data Exchange (ETDEWEB)

    Allgood, G.O.; Ferrell, R.K.; Kercel, S.W.; Abston, R.A.; Carnal, C.L. [Oak Ridge National Lab., TN (United States); Moynihan, P.I. [Jet Propulsion Lab., Pasadena, CA (United States)

    1994-11-01

    Traffic Flow Wide-Area Surveillance (TFWAS) is a system for assessing the state of traffic flow over a wide area for enhanced traffic control and improved traffic management and planning. The primary purpose of a TFWAS system is to provide a detailed traffic flow description and context description to sophisticated traffic management and control systems being developed or envisioned for the future. A successful TFWAS system must possess the attributes of safety, reconfigurability, reliability, and expandability. The primary safety premise of TFWAS is to ensure that no action or failure of the TFWAS system or its components can result in risk of injury to humans. A wide variety of communication techniques is available for use with TFWAS systems. These communication techniques can be broken down into two categories, landlines and wireless. Currently used and possible future traffic sensing technologies have been examined. Important criteria for selecting TFWAS sensors include sensor capabilities, costs, operational constraints, sensor compatibility with the infrastructure, and extent. TFWAS is a concept that can take advantage of the strengths of different traffic sensing technologies, can readily adapt to newly developed technologies, and can grow with the development of new traffic control strategies. By developing innovative algorithms that will take information from a variety of sensor types and develop descriptions of traffic flows over a wide area, a more comprehensive understanding of the traffic state can be provided to the control system to perform the most reasonable control actions over the entire wide area. The capability of characterizing the state of traffic over an entire region should revolutionize developments in traffic control strategies.

  15. Variability in the measurement of hospital-wide mortality rates.

    Science.gov (United States)

    Shahian, David M; Wolf, Robert E; Iezzoni, Lisa I; Kirle, Leslie; Normand, Sharon-Lise T

    2010-12-23

    Several countries use hospital-wide mortality rates to evaluate the quality of hospital care, although the usefulness of this metric has been questioned. Massachusetts policymakers recently requested an assessment of methods to calculate this aggregate mortality metric for use as a measure of hospital quality. The Massachusetts Division of Health Care Finance and Policy provided four vendors with identical information on 2,528,624 discharges from Massachusetts acute care hospitals from October 1, 2004, through September 30, 2007. Vendors applied their risk-adjustment algorithms and provided predicted probabilities of in-hospital death for each discharge and for hospital-level observed and expected mortality rates. We compared the numbers and characteristics of discharges and hospitals included by each of the four methods. We also compared hospitals' standardized mortality ratios and classification of hospitals with mortality rates that were higher or lower than expected, according to each method. The proportions of discharges that were included by each method ranged from 28% to 95%, and the severity of patients' diagnoses varied widely. Because of their discharge-selection criteria, two methods calculated in-hospital mortality rates (4.0% and 5.9%) that were twice the state average (2.1%). Pairwise associations (Pearson correlation coefficients) of discharge-level predicted mortality probabilities ranged from 0.46 to 0.70. Hospital-performance categorizations varied substantially and were sometimes completely discordant. In 2006, a total of 12 of 28 hospitals that had higher-than-expected hospital-wide mortality when classified by one method had lower-than-expected mortality when classified by one or more of the other methods. Four common methods for calculating hospital-wide mortality produced substantially different results. This may have resulted from a lack of standardized national eligibility and exclusion criteria, different statistical methods, or

  16. Wired World-Wide Web Interactive Remote Event Display

    Energy Technology Data Exchange (ETDEWEB)

    De Groot, Nicolo

    2003-05-07

    WIRED (World-Wide Web Interactive Remote Event Display) is a framework, written in the Java{trademark} language, for building High Energy Physics event displays. An event display based on the WIRED framework enables users of a HEP collaboration to visualize and analyze events remotely using ordinary WWW browsers, on any type of machine. In addition, event displays using WIRED may provide the general public with access to the research of high energy physics. The recent introduction of the object-oriented Java{trademark} language enables the transfer of machine independent code across the Internet, to be safely executed by a Java enhanced WWW browser. We have employed this technology to create a remote event display in WWW. The combined Java-WWW technology hence assures a world wide availability of such an event display, an always up-to-date program and a platform independent implementation, which is easy to use and to install.

  17. Genome-wide association studies and resting heart rate

    DEFF Research Database (Denmark)

    Oskari Kilpeläinen, Tuomas

    2016-01-01

    Genome-wide association studies (GWASs) have revolutionized the search for genetic variants regulating resting heart rate. In the last 10 years, GWASs have led to the identification of at least 21 novel heart rate loci. These discoveries have provided valuable insights into the mechanisms...... and pathways that regulate heart rate and link heart rate to cardiovascular morbidity and mortality. GWASs capture majority of genetic variation in a population sample by utilizing high-throughput genotyping chips measuring genotypes for up to several millions of SNPs across the genome in thousands...... of individuals. This allows the identification of the strongest heart rate associated signals at genome-wide level. While GWASs provide robust statistical evidence of the association of a given genetic locus with heart rate, they are only the starting point for detailed follow-up studies to locate the causal...

  18. The Evolving Wide Area Network Infrastructure in the LHC era

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    The global network is more than ever taking its role as the great "enabler" for many branches of science and research. Foremost amongst such science drivers is of course the LHC/LCG programme, although there are several other sectors with growing demands of the network. Common to all of these is the realisation that a straightforward over provisioned best efforts wide area IP service is probably not enough for the future. This talk will summarise the needs of several science sectors, and the advances being made to exploit the current best efforts infrastructure. It will then describe current projects aimed as provisioning "better than best efforts" services (such bandwidth on demand), the global optical R&D testbeds and the strategy of the research network providers to move towards hybrid multi-service networks for the next generation of the global wide area production network.

  19. Origin of African Physacanthus (Acanthaceae via wide hybridization.

    Directory of Open Access Journals (Sweden)

    Erin A Tripp

    Full Text Available Gene flow between closely related species is a frequent phenomenon that is known to play important roles in organismal evolution. Less clear, however, is the importance of hybridization between distant relatives. We present molecular and morphological evidence that support origin of the plant genus Physacanthus via "wide hybridization" between members of two distantly related lineages in the large family Acanthaceae. These two lineages are well characterized by very different morphologies yet, remarkably, Physacanthus shares features of both. Chloroplast sequences from six loci indicate that all three species of Physacanthus contain haplotypes from both lineages, suggesting that heteroplasmy likely predated speciation in the genus. Although heteroplasmy is thought to be unstable and thus transient, multiple haplotypes have been maintained through time in Physacanthus. The most likely scenario to explain these data is that Physacanthus originated via an ancient hybridization event that involved phylogenetically distant parents. This wide hybridization has resulted in the establishment of an independently evolving clade of flowering plants.

  20. Wide-angle display developments by computer graphics

    Science.gov (United States)

    Fetter, William A.

    1989-01-01

    Computer graphics can now expand its new subset, wide-angle projection, to be as significant a generic capability as computer graphics itself. Some prior work in computer graphics is presented which leads to an attractive further subset of wide-angle projection, called hemispheric projection, to be a major communication media. Hemispheric film systems have long been present and such computer graphics systems are in use in simulators. This is the leading edge of capabilities which should ultimately be as ubiquitous as CRTs (cathode-ray tubes). These assertions are not from degrees in science or only from a degree in graphic design, but in a history of computer graphics innovations, laying groundwork by demonstration. The author believes that it is timely to look at several development strategies, since hemispheric projection is now at a point comparable to the early stages of computer graphics, requiring similar patterns of development again.

  1. Two wide-angle imaging neutral-atom spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    McComas, D.J.

    1997-12-31

    The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a new capability for stereoscopically imaging the magnetosphere. By imaging the charge exchange neutral atoms over a broad energy range (1 < E , {approximately} 100 keV) using two identical instruments on two widely-spaced high-altitude, high-inclination spacecraft, TWINS will enable the 3-dimensional visualization and the resolution of large scale structures and dynamics within the magnetosphere for the first time. These observations will provide a leap ahead in the understanding of the global aspects of the terrestrial magnetosphere and directly address a number of critical issues in the ``Sun-Earth Connections`` science theme of the NASA Office of Space Science.

  2. Institution-wide peer mentoring: Benefits for mentors

    Directory of Open Access Journals (Sweden)

    Susan Beltman

    2012-08-01

    Full Text Available Extensive research has shown the benefits of mentoring, including peer mentoring, for higher education students, especially in their first year. However, few studies have focussed exclusively on the outcomes for the mentors themselves. This paper reports the findings of data gathered over three years about a university-wide peer mentoring program. Benefits identified by 858 mentors were coded inductively and four major categories emerged: altruistic, cognitive, social and personal growth. The findings have implications for the promotion of mentor programs to administrators and to prospective mentors. The study provides evidence that university-wide peer mentoring programs offer multiple positive outcomes for the mentors involved, and potentially for higher education institutions administering and supporting such programs. 

  3. Two wide-angle imaging neutral-atom spectrometers

    International Nuclear Information System (INIS)

    McComas, D.J.

    1997-01-01

    The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a new capability for stereoscopically imaging the magnetosphere. By imaging the charge exchange neutral atoms over a broad energy range (1 < E , ∼ 100 keV) using two identical instruments on two widely-spaced high-altitude, high-inclination spacecraft, TWINS will enable the 3-dimensional visualization and the resolution of large scale structures and dynamics within the magnetosphere for the first time. These observations will provide a leap ahead in the understanding of the global aspects of the terrestrial magnetosphere and directly address a number of critical issues in the ''Sun-Earth Connections'' science theme of the NASA Office of Space Science

  4. Wide Binaries in TGAS: Search Method and First Results

    Science.gov (United States)

    Andrews, Jeff J.; Chanamé, Julio; Agüeros, Marcel A.

    2018-04-01

    Half of all stars reside in binary systems, many of which have orbital separations in excess of 1000 AU. Such binaries are typically identified in astrometric catalogs by matching the proper motions vectors of close stellar pairs. We present a fully Bayesian method that properly takes into account positions, proper motions, parallaxes, and their correlated uncertainties to identify widely separated stellar binaries. After applying our method to the >2 × 106 stars in the Tycho-Gaia astrometric solution from Gaia DR1, we identify over 6000 candidate wide binaries. For those pairs with separations less than 40,000 AU, we determine the contamination rate to be ~5%. This sample has an orbital separation (a) distribution that is roughly flat in log space for separations less than ~5000 AU and follows a power law of a -1.6 at larger separations.

  5. Genome-wide association study of serum selenium concentrations

    DEFF Research Database (Denmark)

    Gong, Jian; Hsu, Li; Harrison, Tabitha

    2013-01-01

    Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated...... this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s Health Initiative (WHI). We...... tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p

  6. Advanced MOKE magnetometry in wide-field Kerr-microscopy

    Science.gov (United States)

    Soldatov, I. V.; Schäfer, R.

    2017-10-01

    The measurement of MOKE (Magneto-Optical Kerr Effect) magnetization loops in a wide-field Kerr microscope offers the advantage that the relevant domain images along the loop can be readily recorded. As the microscope's objective lens is exposed to the magnetic field, the loops are usually strongly distorted by non-linear Faraday rotations of the polarized light that occur in the objective lens and that are superimposed to the MOKE signal. In this paper, an experimental method, based on a motorized analyzer, is introduced which allows to compensate the Faraday contributions, thus leading to pure MOKE loops. A wide field Kerr microscope, equipped with this technology, works well as a laser-based MOKE magnetometer, additionally offering domain images and thus providing the basis for loop interpretation.

  7. High voltage wide range marx generator design and construction

    International Nuclear Information System (INIS)

    Thompson, J.E.

    1976-01-01

    A wide range, long pulse, Marx generator has been designed and constructed for the purpose of exciting a thermionic electron gun utilized for quasi-cw gas laser medium ionization. The Marx generator has been specifically designed to operate over a voltage range variable from 100 kV to 200 kV into a resistive load of between 83 kΩ and open circuit. This wide operating range, both in voltage and load impedance, was obtained using interstage coupling capacitors to assure overvoltage and subsequent breakdown of the three element spark gap switches used. This paper will discuss the motivation and specific application for the Marx generator and will present the relevant design procedure with particular emphasis on the interstage coupling and triggering techniques employed. Experimental data regarding the measured Marx generator performance will also be presented

  8. World-wide online monitoring interface of the ATLAS experiment

    CERN Document Server

    Kolos, S; The ATLAS collaboration; Mineev, M; Hauser, R; Salnikov, A

    2014-01-01

    The ATLAS collaboration accounts for more than 3000 members located all over the world. The efficiency of the experiment can be improved allowing system experts not present on site to follow the ATLAS operations in real-time, spotting potential problems which otherwise may remain unattended for a non-negligible time. Taking into account the wide geographical spread of the ATLAS collaboration, the solution of this problem is to have all monitoring information with minimal access latency available world-wide. We have implemented a framework which defines a standard approach for retrieving arbitrary monitoring information from the ATLAS private network via HTTP. An information request is made by specifying one of the predefined URLs with some optional parameters refining data which has to be shipped back in XML format. The framework takes care of receiving, parsing and forwarding such requests to the appropriate plugins. The plugins retrieve the requested data and convert it to XML (or optionally to JSON) format...

  9. Plant-wide integrated equipment monitoring and analysis system

    International Nuclear Information System (INIS)

    Morimoto, C.N.; Hunter, T.A.; Chiang, S.C.

    2004-01-01

    A nuclear power plant equipment monitoring system monitors plant equipment and reports deteriorating equipment conditions. The more advanced equipment monitoring systems can also provide information for understanding the symptoms and diagnosing the root cause of a problem. Maximizing the equipment availability and minimizing or eliminating consequential damages are the ultimate goals of equipment monitoring systems. GE Integrated Equipment Monitoring System (GEIEMS) is designed as an integrated intelligent monitoring and analysis system for plant-wide application for BWR plants. This approach reduces system maintenance efforts and equipment monitoring costs and provides information for integrated planning. This paper describes GEIEMS and how the current system is being upgraded to meet General Electric's vision for plant-wide decision support. (author)

  10. Soil Compressibility Models for a Wide Stress Range

    KAUST Repository

    Chong, Song-Hun

    2016-03-03

    Soil compressibility models with physically correct asymptotic void ratios are required to analyze situations that involve a wide stress range. Previously suggested models and other functions are adapted to satisfy asymptotic void ratios at low and high stress levels; all updated models involve four parameters. Compiled consolidation data for remolded and natural clays are used to test the models and to develop correlations between model parameters and index properties. Models can adequately fit soil compression data for a wide range of stresses and soil types; in particular, models that involve the power of the stress σ\\'β display higher flexibility to capture the brittle response of some natural soils. The use of a single continuous function avoids numerical discontinuities or the need for ad hoc procedures to determine the yield stress. The tangent stiffness-readily computed for all models-should not be mistaken for the small-strain constant-fabric stiffness. © 2016 American Society of Civil Engineers.

  11. Development of high frequency and wide bandwidth Johnson noise thermometry

    International Nuclear Information System (INIS)

    Crossno, Jesse; Liu, Xiaomeng; Kim, Philip; Ohki, Thomas A.; Fong, Kin Chung

    2015-01-01

    We develop a high frequency, wide bandwidth radiometer operating at room temperature, which augments the traditional technique of Johnson noise thermometry for nanoscale thermal transport studies. Employing low noise amplifiers and an analog multiplier operating at 2 GHz, auto- and cross-correlated Johnson noise measurements are performed in the temperature range of 3 to 300 K, achieving a sensitivity of 5.5 mK (110 ppm) in 1 s of integration time. This setup allows us to measure the thermal conductance of a boron nitride encapsulated monolayer graphene device over a wide temperature range. Our data show a high power law (T ∼ 4) deviation from the Wiedemann-Franz law above T ∼ 100 K

  12. Two wide-angle imaging neutral-atom spectrometers (TWINS)

    International Nuclear Information System (INIS)

    McComas, D.J.; Blake, B.; Burch, J.

    1998-01-01

    Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) is a revolutionary new mission designed to stereoscopically image the magnetosphere in charge exchange neutral atoms for the first time. The authors propose to fly two identical TWINS instruments as a mission of opportunity on two widely-spaced high-altitude, high-inclination US Government spacecraft. Because the spacecraft are funded independently, TWINS can provide a vast quantity of high priority science observations (as identified in an ongoing new missions concept study and the Sun-Earth Connections Roadmap) at a small fraction of the cost of a dedicated mission. Because stereo observations of the near-Earth space environs will provide a particularly graphic means for visualizing the magnetosphere in action, and because of the dedication and commitment of the investigator team to the principles of carrying space science to the broader audience, TWINS will also be an outstanding tool for public education and outreach

  13. Simulation studies of a wide area health care network.

    Science.gov (United States)

    McDaniel, J. G.

    1994-01-01

    There is an increasing number of efforts to install wide area health care networks. Some of these networks are being built to support several applications over a wide user base consisting primarily of medical practices, hospitals, pharmacies, medical laboratories, payors, and suppliers. Although on-line, multi-media telecommunication is desirable for some purposes such as cardiac monitoring, store-and-forward messaging is adequate for many common, high-volume applications. Laboratory test results and payment claims, for example, can be distributed using electronic messaging networks. Several network prototypes have been constructed to determine the technical problems and to assess the effectiveness of electronic messaging in wide area health care networks. Our project, Health Link, developed prototype software that was able to use the public switched telephone network to exchange messages automatically, reliably and securely. The network could be configured to accommodate the many different traffic patterns and cost constraints of its users. Discrete event simulations were performed on several network models. Canonical star and mesh networks, that were composed of nodes operating at steady state under equal loads, were modeled. Both topologies were found to support the throughput of a generic wide area health care network. The mean message delivery time of the mesh network was found to be less than that of the star network. Further simulations were conducted for a realistic large-scale health care network consisting of 1,553 doctors, 26 hospitals, four medical labs, one provincial lab and one insurer. Two network topologies were investigated: one using predominantly peer-to-peer communication, the other using client-server communication.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7949966

  14. Genome-wide association study of pathological gambling.

    Science.gov (United States)

    Lang, M; Leménager, T; Streit, F; Fauth-Bühler, M; Frank, J; Juraeva, D; Witt, S H; Degenhardt, F; Hofmann, A; Heilmann-Heimbach, S; Kiefer, F; Brors, B; Grabe, H-J; John, U; Bischof, A; Bischof, G; Völker, U; Homuth, G; Beutel, M; Lind, P A; Medland, S E; Slutske, W S; Martin, N G; Völzke, H; Nöthen, M M; Meyer, C; Rumpf, H-J; Wurst, F M; Rietschel, M; Mann, K F

    2016-08-01

    Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes and pathways may improve understanding of aetiology and facilitate therapy and prevention. Here, we report the first genome-wide association study of pathological gambling. Our aims were to identify pathways involved in pathological gambling, and examine whether there is a genetic overlap between pathological gambling and alcohol dependence. Four hundred and forty-five individuals with a diagnosis of pathological gambling according to the Diagnostic and Statistical Manual of Mental Disorders were recruited in Germany, and 986 controls were drawn from a German general population sample. A genome-wide association study of pathological gambling comprising single marker, gene-based, and pathway analyses, was performed. Polygenic risk scores were generated using data from a German genome-wide association study of alcohol dependence. No genome-wide significant association with pathological gambling was found for single markers or genes. Pathways for Huntington's disease (P-value=6.63×10(-3)); 5'-adenosine monophosphate-activated protein kinase signalling (P-value=9.57×10(-3)); and apoptosis (P-value=1.75×10(-2)) were significant. Polygenic risk score analysis of the alcohol dependence dataset yielded a one-sided nominal significant P-value in subjects with pathological gambling, irrespective of comorbid alcohol dependence status. The present results accord with previous quantitative formal genetic studies which showed genetic overlap between non-substance- and substance-related addictions. Furthermore, pathway analysis suggests shared pathology between Huntington's disease and pathological gambling. This finding is consistent with previous imaging studies. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  15. Multi Agent System Based Wide Area Protection against Cascading Events

    DEFF Research Database (Denmark)

    Liu, Zhou; Chen, Zhe; Liu, Leo

    2012-01-01

    In this paper, a multi-agent system based wide area protection scheme is proposed in order to prevent long term voltage instability induced cascading events. The distributed relays and controllers work as a device agent which not only executes the normal function automatically but also can...... the effectiveness of proposed protection strategy. The simulation results indicate that the proposed multi agent control system can effectively coordinate the distributed relays and controllers to prevent the long term voltage instability induced cascading events....

  16. Data handling for the wide-angle hall jet experiment

    International Nuclear Information System (INIS)

    Cassel, D.; Engelmann, R.; Gordon, H.; Grannis, P.; Mallik, U.; Meadows, B.; Morris, T.; Plano, R.; Saulys, A.; Stein, S.

    1978-01-01

    The data handling needs for a jet production experiment in the wide-angle hall are discussed. The several layers of triggering and a data acquisition system were designed, the configuration of the local intersection computer system was discussed, and the time required to analyze a typical event was estimated. It was concluded that the experiment does not appear to place unrealistic demands on detector technology. The slow trigger was believed to be the crucial aspect of the experiment. 15 figures, 1 tables

  17. Building a Practical Framework for Enterprise-Wide Security Management

    Science.gov (United States)

    2004-04-28

    several widely accepted and used sources (specifically ISO 17799, COBIT , ITIL, and selected NIST 800 series special publications) led us to a set of eight...1 • ISO 17799/British Standards Institute 7799 Part 2 • Control Objectives for Information and related Technology ( COBIT ) • Information Technology...The article addresses CMM, COBIT , ITIL, Six Sigma, ISO 9000, and Malcolm Baldrige Framework sources: British Standards Institution (BSI). IT

  18. Community-Wide Zero Energy Ready Home Standard

    Energy Technology Data Exchange (ETDEWEB)

    Herk, A. [IBACOS, Inc., Pittsburgh, PA (United States); Beggs, T. [IBACOS, Inc., Pittsburgh, PA (United States)

    2016-02-05

    This report outlines the steps a developer can take when creating and implementing high performance standards such as the U.S. Department of Energy’s (DOE’s) Zero Energy Ready Home (ZERH) standards on a community-wide scale. The report also describes the specific examples of how this process is underway in the Stapleton community in Denver, Colorado, by the developer Forest City.

  19. Tim Berners-Lee, World Wide Web inventor

    CERN Multimedia

    1994-01-01

    Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

  20. THE FORMATION MECHANISM OF GAS GIANTS ON WIDE ORBITS

    International Nuclear Information System (INIS)

    Dodson-Robinson, Sarah E.; Veras, Dimitri; Ford, Eric B.; Beichman, C. A.

    2009-01-01

    The recent discoveries of massive planets on ultra-wide orbits of HR 8799 and Fomalhaut present a new challenge for planet formation theorists. Our goal is to figure out which of three giant planet formation mechanisms-core accretion (with or without migration), scattering from the inner disk, or gravitational instability-could be responsible for Fomalhaut b, HR 8799 b, c and d, and similar planets discovered in the future. This paper presents the results of numerical experiments comparing the long-period planet formation efficiency of each possible mechanism in model A star, G star, and M star disks. First, a simple core accretion simulation shows that planet cores forming beyond 35 AU cannot reach critical mass, even under the most favorable conditions one can construct. Second, a set of N-body simulations demonstrates that planet-planet scattering does not create stable, wide-orbit systems such as HR 8799. Finally, a linear stability analysis verifies previous work showing that global spiral instabilities naturally arise in high-mass disks. We conclude that massive gas giants on stable orbits with semimajor axes a ∼> 35 AU form by gravitational instability in the disk. We recommend that observers examine the planet detection rate as a function of stellar age, controlling for the planets' dimming with time. Any age trend would indicate that planets on wide orbits are transient relics of scattering from the inner disk. If planet detection rate is found to be independent of stellar age, it would confirm our prediction that gravitational instability is the dominant mode of producing detectable planets on wide orbits. We also predict that the occurrence ratio of long-period to short-period gas giants should be highest for M dwarfs due to the inefficiency of core accretion and the expected small fragment mass (∼10 M Jup ) in their disks.

  1. Collaborative Information Agents on the World Wide Web

    Science.gov (United States)

    Chen, James R.; Mathe, Nathalie; Wolfe, Shawn; Koga, Dennis J. (Technical Monitor)

    1998-01-01

    In this paper, we present DIAMS, a system of distributed, collaborative information agents which help users access, collect, organize, and exchange information on the World Wide Web. Personal agents provide their owners dynamic displays of well organized information collections, as well as friendly information management utilities. Personal agents exchange information with one another. They also work with other types of information agents such as matchmakers and knowledge experts to facilitate collaboration and communication.

  2. Role of Librarian in Internet and World Wide Web Environment

    OpenAIRE

    K. Nageswara Rao; KH Babu

    2001-01-01

    The transition of traditional library collections to digital or virtual collections presented the librarian with new opportunities. The Internet, Web en-vironment and associated sophisticated tools have given the librarian a new dynamic role to play and serve the new information based society in bet-ter ways than hitherto. Because of the powerful features of Web i.e. distributed, heterogeneous, collaborative, multimedia, multi-protocol, hyperme-dia-oriented architecture, World Wide Web has re...

  3. WorldWide Telescope Ambassadors: A Year 3 Update

    OpenAIRE

    Udomprasert, Patricia S; Goodman, Alyssa A.; Wong, Curtis

    2013-01-01

    We give a brief overview of some key features of WorldWide Telescope and its Ambassadors Program, and we describe two goals for expanding the program in the coming year: scaling up training efforts; and developing “plug and play” Visualization Lab modules that teach key Earth and Space Science concepts to students while emphasizing important scientific processes and skills. We discuss several different ways that members of the astronomy education and outreach community can incorporate WWT-bas...

  4. ALGORITHMIC support for THE System Wide Information Management concept

    OpenAIRE

    2016-01-01

    The theoretical problems of computer support for the "System Wide Information Management" concept, which was proposed by experts of the International Civil Aviation Organization, are discussed. Within the framework of its provisions certain new requirements for all initial stages of air traffic management preceding the direct aircrafts control are formulated. Algorithmic instruments for ensuring a conflictlessness of a summary plan for the use of airspace during the plan’s implementation are ...

  5. Designing Phononic Crystals with Wide and Robust Band Gaps

    Science.gov (United States)

    Jia, Zian; Chen, Yanyu; Yang, Haoxiang; Wang, Lifeng

    2018-04-01

    Phononic crystals (PnCs) engineered to manipulate and control the propagation of mechanical waves have enabled the design of a range of novel devices, such as waveguides, frequency modulators, and acoustic cloaks, for which wide and robust phononic band gaps are highly preferable. While numerous PnCs have been designed in recent decades, to the best of our knowledge, PnCs that possess simultaneous wide and robust band gaps (to randomness and deformations) have not yet been reported. Here, we demonstrate that by combining the band-gap formation mechanisms of Bragg scattering and local resonances (the latter one is dominating), PnCs with wide and robust phononic band gaps can be established. The robustness of the phononic band gaps are then discussed from two aspects: robustness to geometric randomness (manufacture defects) and robustness to deformations (mechanical stimuli). Analytical formulations further predict the optimal design parameters, and an uncertainty analysis quantifies the randomness effect of each designing parameter. Moreover, we show that the deformation robustness originates from a local resonance-dominant mechanism together with the suppression of structural instability. Importantly, the proposed PnCs require only a small number of layers of elements (three unit cells) to obtain broad, robust, and strong attenuation bands, which offer great potential in designing flexible and deformable phononic devices.

  6. Formation of the wide asynchronous binary asteroid population

    International Nuclear Information System (INIS)

    Jacobson, Seth A.; Scheeres, Daniel J.; McMahon, Jay

    2014-01-01

    We propose and analyze a new mechanism for the formation of the wide asynchronous binary population. These binary asteroids have wide semimajor axes relative to most near-Earth and main belt asteroid systems. Confirmed members have rapidly rotating primaries and satellites that are not tidally locked. Previously suggested formation mechanisms from impact ejecta, from planetary flybys, and directly from rotational fission events cannot satisfy all of the observations. The newly hypothesized mechanism works as follows: (1) these systems are formed from rotational fission, (2) their satellites are tidally locked, (3) their orbits are expanded by the binary Yarkovsky-O'Keefe-Radzievskii-Paddack (BYORP) effect, (4) their satellites desynchronize as a result of the adiabatic invariance between the libration of the secondary and the mutual orbit, and (5) the secondary avoids resynchronization because of the YORP effect. This seemingly complex chain of events is a natural pathway for binaries with satellites that have particular shapes, which define the BYORP effect torque that acts on the system. After detailing the theory, we analyze each of the wide asynchronous binary members and candidates to assess their most likely formation mechanism. Finally, we suggest possible future observations to check and constrain our hypothesis.

  7. Adiponectin Concentrations: A Genome-wide Association Study

    Science.gov (United States)

    Jee, Sun Ha; Sull, Jae Woong; Lee, Jong-Eun; Shin, Chol; Park, Jongkeun; Kimm, Heejin; Cho, Eun-Young; Shin, Eun-Soon; Yun, Ji Eun; Park, Ji Wan; Kim, Sang Yeun; Lee, Sun Ju; Jee, Eun Jung; Baik, Inkyung; Kao, Linda; Yoon, Sungjoo Kim; Jang, Yangsoo; Beaty, Terri H.

    2010-01-01

    Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10−15 in the initial sample, p = 6.58 × 10−39 in the second genome-wide sample, and p = 2.12 × 10−32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10−83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10−58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults. PMID:20887962

  8. Genome-Wide Detection and Analysis of Multifunctional Genes

    Science.gov (United States)

    Pritykin, Yuri; Ghersi, Dario; Singh, Mona

    2015-01-01

    Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular functioning, thereby leading to a better understanding of the functional landscape of the cell. However, to date, genome-wide analysis of multifunctional genes (and the proteins they encode) has been limited. Here we introduce a computational approach that uses known functional annotations to extract genes playing a role in at least two distinct biological processes. We leverage functional genomics data sets for three organisms—H. sapiens, D. melanogaster, and S. cerevisiae—and show that, as compared to other annotated genes, genes involved in multiple biological processes possess distinct physicochemical properties, are more broadly expressed, tend to be more central in protein interaction networks, tend to be more evolutionarily conserved, and are more likely to be essential. We also find that multifunctional genes are significantly more likely to be involved in human disorders. These same features also hold when multifunctionality is defined with respect to molecular functions instead of biological processes. Our analysis uncovers key features about multifunctional genes, and is a step towards a better genome-wide understanding of gene multifunctionality. PMID:26436655

  9. Designing Phononic Crystals with Wide and Robust Band Gaps

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yanyu [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jia, Zian [State University of New York at Stony Brook; Yang, Haoxiang [State University of New York at Stony Brook; Wang, Lifeng [State University of New York at Stony Brook

    2018-04-16

    Phononic crystals (PnCs) engineered to manipulate and control the propagation of mechanical waves have enabled the design of a range of novel devices, such as waveguides, frequency modulators, and acoustic cloaks, for which wide and robust phononic band gaps are highly preferable. While numerous PnCs have been designed in recent decades, to the best of our knowledge, PnCs that possess simultaneous wide and robust band gaps (to randomness and deformations) have not yet been reported. Here, we demonstrate that by combining the band-gap formation mechanisms of Bragg scattering and local resonances (the latter one is dominating), PnCs with wide and robust phononic band gaps can be established. The robustness of the phononic band gaps are then discussed from two aspects: robustness to geometric randomness (manufacture defects) and robustness to deformations (mechanical stimuli). Analytical formulations further predict the optimal design parameters, and an uncertainty analysis quantifies the randomness effect of each designing parameter. Moreover, we show that the deformation robustness originates from a local resonance-dominant mechanism together with the suppression of structural instability. Importantly, the proposed PnCs require only a small number of layers of elements (three unit cells) to obtain broad, robust, and strong attenuation bands, which offer great potential in designing flexible and deformable phononic devices.

  10. Wide-area situation awareness in electric power grid

    Science.gov (United States)

    Greitzer, Frank L.

    2010-04-01

    Two primary elements of the US energy policy are demand management and efficiency and renewable sources. Major objectives are clean energy transmission and integration, reliable energy transmission, and grid cyber security. Development of the Smart Grid seeks to achieve these goals by lowering energy costs for consumers, achieving energy independence and reducing greenhouse gas emissions. The Smart Grid is expected to enable real time wide-area situation awareness (SA) for operators. Requirements for wide-area SA have been identified among interoperability standards proposed by the Federal Energy Regulatory Commission and the National Institute of Standards and Technology to ensure smart-grid functionality. Wide-area SA and enhanced decision support and visualization tools are key elements in the transformation to the Smart Grid. This paper discusses human factors research to promote SA in the electric power grid and the Smart Grid. Topics that will be discussed include the role of human factors in meeting US energy policy goals, the impact and challenges for Smart Grid development, and cyber security challenges.

  11. Genome-wide DNA polymorphism analyses using VariScan

    Directory of Open Access Journals (Sweden)

    Vilella Albert J

    2006-09-01

    Full Text Available Abstract Background DNA sequence polymorphisms analysis can provide valuable information on the evolutionary forces shaping nucleotide variation, and provides an insight into the functional significance of genomic regions. The recent ongoing genome projects will radically improve our capabilities to detect specific genomic regions shaped by natural selection. Current available methods and software, however, are unsatisfactory for such genome-wide analysis. Results We have developed methods for the analysis of DNA sequence polymorphisms at the genome-wide scale. These methods, which have been tested on a coalescent-simulated and actual data files from mouse and human, have been implemented in the VariScan software package version 2.0. Additionally, we have also incorporated a graphical-user interface. The main features of this software are: i exhaustive population-genetic analyses including those based on the coalescent theory; ii analysis adapted to the shallow data generated by the high-throughput genome projects; iii use of genome annotations to conduct a comprehensive analyses separately for different functional regions; iv identification of relevant genomic regions by the sliding-window and wavelet-multiresolution approaches; v visualization of the results integrated with current genome annotations in commonly available genome browsers. Conclusion VariScan is a powerful and flexible suite of software for the analysis of DNA polymorphisms. The current version implements new algorithms, methods, and capabilities, providing an important tool for an exhaustive exploratory analysis of genome-wide DNA polymorphism data.

  12. Overcoming mixed waste management obstacles - A company wide approach

    International Nuclear Information System (INIS)

    Buckley, R.N.

    1996-01-01

    The dual regulation of mixed waste by the Nuclear Regulatory Commission and the Environmental Protection Agency has significantly complicated the treatment, storage and disposal of this waste. Because of the limited treatment and disposal options available, facilities generating mixed waste are also being forced to acquire storage permits to meet requirements associated with the Resource Conservation and Recovery Act. Due to the burdens imposed by the regulatory climate, Entergy Operations has undertaken a proactive approach to managing its mixed waste. Their approach is company wide and simplistic in nature. Utilizing the peer groups to develop strategies and a company wide procedure for guidance on mixed waste activities, they have focused on areas where they have the most control and can achieve the greatest benefits from their efforts. A key aspect of the program includes training and employee awareness regarding mixed waste minimization practices. In addition, Entergy Operations is optimizing the implementation of regulatory provisions that facilitate more flexible management practices for mixed waste. This presentation focuses on the team approach to developing mixed waste managements programs and the utilization of innovative thinking and planning to minimize the regulatory burdens. It will also describe management practices and philosophies that have provided more flexibility in implementing a safe and effective company wide mixed waste management program

  13. Region of Interest Selection Interface for Wide-Angle Arthroscope

    Directory of Open Access Journals (Sweden)

    Jung Kyunghwa

    2015-01-01

    Full Text Available We have proposed a new interface for an wide-angle endoscope for solo surgery. The wide-angle arthroscopic view and magnified region of interest (ROI within the wide view were shown simultaneously. With a camera affixed to surgical instruments, the position of the ROI could be determined by manipulating the surgical instrument. Image features acquired by the A-KAZE approach were used to estimate the change of position of the surgical instrument by tracking the features every time the camera moved. We examined the accuracy of ROI selection using three different images, which were different-sized square arrays and tested phantom experiments. When the number of ROIs was twelve, the success rate was best, and the rate diminished as the size of ROIs decreased. The experimental results showed that the method of using a camera without additional sensors satisfied the appropriate accuracy required for ROI selection, and this interface was helpful in performing surgery with fewer assistants.

  14. Development of Autonomous Magnetometer Rotorcraft For Wide Area Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mark D. McKay; Matthew O. Anderson

    2011-08-01

    Large areas across the United States and internationally are potentially contaminated with unexploded ordinance (UXO), with some ranges encompassing tens to hundreds of thousands of acres. Technologies are needed which will allow for cost effective wide area scanning with (1) near 100% coverage and (2) near 100% detection of subsurface ordnance or features indicative of subsurface ordnance. The current approach to wide area assessment is a multi-level one, in which medium - altitude fixed wing optical imaging is used for an initial site assessment. This assessment is followed with low altitude manned helicopter based magnetometry. Subsequent to this wide area assessment targeted surface investigations are performed using either towed geophysical sensor arrays or man portable sensors. In order to be an effective tool for small UXO detection, the sensing altitude for magnetic site investigations needs to be on the order of 1 to 3 meters. These altitude requirements mean that manned helicopter surveys will generally only be feasible in large, open and relatively flat terrains. While such surveys are effective in mapping large areas relatively fast there are substantial mobilization/demobilization, staffing and equipment costs associated with these surveys, resulting in costs of approximately $100-$150/acre. In addition, due to the low altitude there are substantial risks to pilots and equipment. Surface towed arrays provide highresolution maps but have other limitations, e.g. in their ability to navigate rough terrain effectively. Thus there is a need for other systems, which can be used for effective data collection. An Unmanned Aerial Vehicle (UAV) magnetometer platform is an obvious alternative. The motivation behind such a system is that it reduces risk to operators, is lower in initial and Operational and Maintenance (O&M) costs (and can thus potentially be applied to smaller sites) and has the potential of being more effective in terms of detection and possibly

  15. Genetically contextual effects of smoking on genome wide DNA methylation.

    Science.gov (United States)

    Dogan, Meeshanthini V; Beach, Steven R H; Philibert, Robert A

    2017-09-01

    Smoking is the leading cause of death in the United States. It exerts its effects by increasing susceptibility to a variety of complex disorders among those who smoke, and if pregnant, to their unborn children. In prior efforts to understand the epigenetic mechanisms through which this increased vulnerability is conveyed, a number of investigators have conducted genome wide methylation analyses. Unfortunately, secondary to methodological limitations, these studies were unable to examine methylation in gene regions with significant amounts of genetic variation. Using genome wide genetic and epigenetic data from the Framingham Heart Study, we re-examined the relationship of smoking status to genome wide methylation status. When only methylation status is considered, smoking was significantly associated with differential methylation in 310 genes that map to a variety of biological process and cellular differentiation pathways. However, when SNP effects on the magnitude of smoking associated methylation changes are also considered, cis and trans-interaction effects were noted at a total of 266 and 4353 genes with no marked enrichment for any biological pathways. Furthermore, the SNP variation participating in the significant interaction effects is enriched for loci previously associated with complex medical illnesses. The enlarged scope of the methylome shown to be affected by smoking may better explicate the mediational pathways linking smoking with a myriad of smoking related complex syndromes. Additionally, these results strongly suggest that combined epigenetic and genetic data analyses may be critical for a more complete understanding of the relationship between environmental variables, such as smoking, and pathophysiological outcomes. © 2017 Wiley Periodicals, Inc.

  16. Genome-wide association study of antisocial personality disorder.

    Science.gov (United States)

    Rautiainen, M-R; Paunio, T; Repo-Tiihonen, E; Virkkunen, M; Ollila, H M; Sulkava, S; Jolanki, O; Palotie, A; Tiihonen, J

    2016-09-06

    The pathophysiology of antisocial personality disorder (ASPD) remains unclear. Although the most consistent biological finding is reduced grey matter volume in the frontal cortex, about 50% of the total liability to developing ASPD has been attributed to genetic factors. The contributing genes remain largely unknown. Therefore, we sought to study the genetic background of ASPD. We conducted a genome-wide association study (GWAS) and a replication analysis of Finnish criminal offenders fulfilling DSM-IV criteria for ASPD (N=370, N=5850 for controls, GWAS; N=173, N=3766 for controls and replication sample). The GWAS resulted in suggestive associations of two clusters of single-nucleotide polymorphisms at 6p21.2 and at 6p21.32 at the human leukocyte antigen (HLA) region. Imputation of HLA alleles revealed an independent association with DRB1*01:01 (odds ratio (OR)=2.19 (1.53-3.14), P=1.9 × 10(-5)). Two polymorphisms at 6p21.2 LINC00951-LRFN2 gene region were replicated in a separate data set, and rs4714329 reached genome-wide significance (OR=1.59 (1.37-1.85), P=1.6 × 10(-9)) in the meta-analysis. The risk allele also associated with antisocial features in the general population conditioned for severe problems in childhood family (β=0.68, P=0.012). Functional analysis in brain tissue in open access GTEx and Braineac databases revealed eQTL associations of rs4714329 with LINC00951 and LRFN2 in cerebellum. In humans, LINC00951 and LRFN2 are both expressed in the brain, especially in the frontal cortex, which is intriguing considering the role of the frontal cortex in behavior and the neuroanatomical findings of reduced gray matter volume in ASPD. To our knowledge, this is the first study showing genome-wide significant and replicable findings on genetic variants associated with any personality disorder.

  17. Genome-Wide Approaches to Drosophila Heart Development

    Directory of Open Access Journals (Sweden)

    Manfred Frasch

    2016-05-01

    Full Text Available The development of the dorsal vessel in Drosophila is one of the first systems in which key mechanisms regulating cardiogenesis have been defined in great detail at the genetic and molecular level. Due to evolutionary conservation, these findings have also provided major inputs into studies of cardiogenesis in vertebrates. Many of the major components that control Drosophila cardiogenesis were discovered based on candidate gene approaches and their functions were defined by employing the outstanding genetic tools and molecular techniques available in this system. More recently, approaches have been taken that aim to interrogate the entire genome in order to identify novel components and describe genomic features that are pertinent to the regulation of heart development. Apart from classical forward genetic screens, the availability of the thoroughly annotated Drosophila genome sequence made new genome-wide approaches possible, which include the generation of massive numbers of RNA interference (RNAi reagents that were used in forward genetic screens, as well as studies of the transcriptomes and proteomes of the developing heart under normal and experimentally manipulated conditions. Moreover, genome-wide chromatin immunoprecipitation experiments have been performed with the aim to define the full set of genomic binding sites of the major cardiogenic transcription factors, their relevant target genes, and a more complete picture of the regulatory network that drives cardiogenesis. This review will give an overview on these genome-wide approaches to Drosophila heart development and on computational analyses of the obtained information that ultimately aim to provide a description of this process at the systems level.

  18. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.

    Science.gov (United States)

    Riechmann, J L; Heard, J; Martin, G; Reuber, L; Jiang, C; Keddie, J; Adam, L; Pineda, O; Ratcliffe, O J; Samaha, R R; Creelman, R; Pilgrim, M; Broun, P; Zhang, J Z; Ghandehari, D; Sherman, B K; Yu, G

    2000-12-15

    The completion of the Arabidopsis thaliana genome sequence allows a comparative analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis dedicates over 5% of its genome to code for more than 1500 transcription factors, about 45% of which are from families specific to plants. Arabidopsis transcription factors that belong to families common to all eukaryotes do not share significant similarity with those of the other kingdoms beyond the conserved DNA binding domains, many of which have been arranged in combinations specific to each lineage. The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription.

  19. Wide Operating Voltage Range Fuel Cell Battery Charger

    DEFF Research Database (Denmark)

    Hernandez Botella, Juan Carlos; Mira Albert, Maria del Carmen; Sen, Gokhan

    2014-01-01

    DC-DC converters for fuel cell applications require wide voltage range operation due to the unique fuel cell characteristic curve. Primary parallel isolated boost converter (PPIBC) is a boost derived topology for low voltage high current applications reaching an efficiency figure up to 98...... by two the converter input-to-output voltage gain. This allows covering the conditions when the fuel cell stack operates in the activation region (maximum output voltage) and increases the degrees of freedom for converter optimization. The transition between operating modes is studied because represents...

  20. Microbial genome-wide association studies: lessons from human GWAS.

    Science.gov (United States)

    Power, Robert A; Parkhill, Julian; de Oliveira, Tulio

    2017-01-01

    The reduced costs of sequencing have led to whole-genome sequences for a large number of microorganisms, enabling the application of microbial genome-wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to further advance our understanding of infectious diseases. These advances include insights into pressing global health problems, such as antibiotic resistance and disease transmission. In this Review, we outline the methodologies of GWAS, the current state of the field of microbial GWAS, and how lessons from human GWAS can direct the future of the field.

  1. Doped silicene: Evidence of a wide stability range

    KAUST Repository

    Cheng, Yingchun

    2011-06-17

    The effects of doping on the lattice structure, electronic structure, phonon spectrum, and electron-phonon coupling of low-buckling silicene are studied by first-principles calculations. Although the lattice is found to be very sensitive to the carrier concentration, it is stable in a wide doping range. The frequencies of the E2g-Γ and A′-K Raman modes can be used to probe the carrier concentration. In addition, the phonon dispersion displays Kohn anomalies at the Γ and K points which are reduced by doping. This implies that the electron-phonon coupling cannot be neglected in field-effect transistor applications. Copyright © 2011 EPLA.

  2. Area-wide population suppression of codling moth

    International Nuclear Information System (INIS)

    Calkins, C.O.; Knight, A.L.; Richardson, G.; Bloem, K.A.

    2000-01-01

    The area-wide pest population control concept began with E.F. Knipling (1979) in the 1970s. Control of a pest population on individual fields does little to control the overall pest population because only a portion of the population is being affected. Expanding control tactics beyond individual farms tends to suppress the population on a wider scale and frequently results in suppression of the population for more than one year. The Agriculture Research Service (ARS) believes that this concept has not been addressed with the focus and support that it deserves. The ARS Administration made a conscious decision in 1994 to create a series of area-wide programmes funded out of ARS-based funds that had previously been used for pilot tests. These programmes involve a coordinated effort among ARS and university scientists, growers, and fieldmen for agriculture supply centres and fruit packing houses. The first area-wide programme supported by ARS was the codling moth (CM), Cydia pomonella L. (Lepidoptera: Tortricidae) suppression programme. The codling moth is the key pest of pome fruit throughout the western United States (Beers et al. 1993). About half of the insecticides applied on these crops are directed toward this pest. A non-insecticidal control technique, mating disruption (MD), is available to replace the organophosphates. Removal of the hard pesticides directed against this pest would do the most to allow natural enemies to survive and reproduce in the orchards, which in turn would have the effect of reducing secondary pests. Elimination of the pesticides would also remove much of the health risks to workers and would minimise buildup of pesticide resistance. The objectives of the Codling Moth Area-wide Program are to enhance the efficacy of the non-pesticide approach, to demonstrate that mating disruption will work if conducted properly, to develop biological technology to lower costs of control that complement mating disruption, to implement effective

  3. Genome-wide detection of selection and other evolutionary forces

    DEFF Research Database (Denmark)

    Xu, Zhuofei; Zhou, Rui

    2015-01-01

    As is well known, pathogenic microbes evolve rapidly to escape from the host immune system and antibiotics. Genetic variations among microbial populations occur frequently during the long-term pathogen–host evolutionary arms race, and individual mutation beneficial for the fitness can be fixed...... to scan genome-wide alignments for evidence of positive Darwinian selection, recombination, and other evolutionary forces operating on the coding regions. In this chapter, we describe an integrative analysis pipeline and its application to tracking featured evolutionary trajectories on the genome...

  4. Pest management strategies: Area-wide and conventional

    International Nuclear Information System (INIS)

    Lindquist, D.A.

    2000-01-01

    Conventional Insect Control The usual approach to insect control is to treat the commodity only after a damaging population of insects has developed. In other words, the producer, home owner or casual gardener fights a defensive battle. He reacts to an insect attack. When he sees the enemy or the damage caused by the enemy, he loads up his sprayer with an insecticide and mounts a counter attack. Most insect control procedures are applied by an individual producer on his own relatively small production area. This conventional insect control approach encourages the producer to make his own decisions about whether or not any insect control is to be used, which insect control method or product to use, when to use it, how to use it, who applies it, etc. Advice to producers on insect control is usually available from government extension personnel, private insect control consultants or representatives of companies that sell insecticides or other insect control materials or methods. The conventional procedure results in great variability in the efficacy of insect control because each producer makes his own decisions. The objective of conventional insect control is to protect the commodity. This is usually accomplished by treating the commodity, be it cows or corn or rice in a warehouse. Conventional insect control requires virtually no planning to achieve results. The 'programme' is short-term, frequently measured in days until the next insecticide application is needed. It is reactive (defensive). Area-wide Insect Control Area-wide insect control is applied against an important insect pest over a relatively large area involving many individual producers of the same or similar crops. The 'area' is a combination of geography and the range of hosts of the target insect pest. The term 'area' in 'area-wide' refers to the area where the target insect population survives. The area is not limited to production of the major crop(s) to be protected. It is very likely that a large

  5. Widely tunable femtosecond solitonic radiation in photonic crystal fiber cladding

    DEFF Research Database (Denmark)

    Peng, J. H.; Sokolov, A. V.; Benabid, F.

    2010-01-01

    We report on a means to generate tunable ultrashort optical pulses. We demonstrate that dispersive waves generated by solitons within the small-core features of a photonic crystal fiber cladding can be used to obtain femtosecond pulses tunable over an octave-wide spectral range. The generation...... process is highly efficient and occurs at the relatively low laser powers available from a simple Ti:sapphire laser oscillator. The described phenomenon is general and will play an important role in other systems where solitons are known to exist....

  6. Trends in the wide web converting markets for UV curing

    International Nuclear Information System (INIS)

    Fisher, R.

    1999-01-01

    As we prepare to enter a new decade, the use of ultraviolet (UV) energy to initiate the polymerization of coatings in the wide web segment of the Converting industry continues to increase. As is typical in the Converting industry, while many of the significant advances in technology have been developed around the world, they have been driven initially by the Western European markets. This was true with regards to the introduction of water-borne Pressure Sensitive Adhesives and thermal curing 100% solids silicone release coatings during the late 1970s and early 1980s, but this trend has changed with regards to the current state-of-the-art in UV curing

  7. Bayes-Based Fault Discrimination in Wide Area Backup Protection

    Directory of Open Access Journals (Sweden)

    WANG, Z.

    2012-02-01

    Full Text Available Multivariate statistical analysis is an effective tool to finish the fault location for electric power system. In Bayesian discriminant analysis as a subbranch, by the research of several populations, one can calculate the conditional probability that some samples belong to these populations, and compare the corresponding probability. The sample will be classified as population with maximum probability. In this paper, based on Bayesian discriminant analysis principle, a great number of simulation examples have confirmed that the results of Bayesian fault discriminant in wide area backup protection are accurate and reliable.

  8. World-wide termination of nuclear energy application

    International Nuclear Information System (INIS)

    Quirin, W.

    1991-01-01

    It is easy to require the widely discussed termination of nuclear energy application, but it is hardly possible to realise it, unless one is prepared to accept enormous economic and ecological problems. The article investigates, whether the other energy carriers or energy saving methods, respectively, would be in a position to replace the nuclear energy. Thereby the aspects of securing the supply and its economy are of considerable importance. The author describes furthermore the effects of terminating nuclear energy on the growing world population and the economy of trading countries. Ecological problems that may also be aggravated are dealt with, too. (orig.) [de

  9. Distributing flight dynamics products via the World Wide Web

    Science.gov (United States)

    Woodard, Mark; Matusow, David

    1996-01-01

    The NASA Flight Dynamics Products Center (FDPC), which make available selected operations products via the World Wide Web, is reported on. The FDPC can be accessed from any host machine connected to the Internet. It is a multi-mission service which provides Internet users with unrestricted access to the following standard products: antenna contact predictions; ground tracks; orbit ephemerides; mean and osculating orbital elements; earth sensor sun and moon interference predictions; space flight tracking data network summaries; and Shuttle transport system predictions. Several scientific data bases are available through the service.

  10. Economics of area-wide sit control programs

    International Nuclear Information System (INIS)

    Enkerlin, Walther

    2003-01-01

    The economic feasibility of using the sterile insect technique (SIT) to control certain key insect pests has been demonstrated clearly. The successful implementation of a number of area-wide and large-scale SIT programs has produced substantial economic benefits for the beneficiaries of the technology. The economic advantages of this technology will become more evident as indirect benefits of SIT application are incorporated into total program benefit estimates. Awareness of the technical and economic advantages of the SIT, and market forces favoring the use of environmentally clean pest control methods, will encourage private investment in this technology. (author)

  11. Status of research reactor spent fuel world-wide

    International Nuclear Information System (INIS)

    Ritchie, I.G.

    2004-01-01

    Results compiled in the research reactor spent fuel database are used to assess the status of research reactor spent fuel world-wide. Fuel assemblies, their types, enrichment, origin of enrichment and geological distribution among the industrialised and developed countries of the world are discussed. Fuel management practices in wet and dry storage facilities and the concerns of reactor operators about long-term storage of their spent fuel are presented and some of the activities carried out by the International Atomic Energy Agency to address the issues associated with research reactor spent fuel are outlined. (author)

  12. Mapping world-wide science at the paper level.

    Energy Technology Data Exchange (ETDEWEB)

    Klavans, Richard (SciTech Strategies, Inc., Berwyn, PA); Boyack, Kevin W.

    2005-01-01

    This article describes recent improvements in mapping a highly representative set of the world-wide scientific literature. The process described in this article extends existing work in this area in three major ways. First, we argue that a separate structural analysis of current literature vs. reference literature is required for R&D planning. Second, visualization software is used to improve coverage of the literature while maintaining structural integrity. Third, quantitative techniques for measuring the structural integrity of a map are introduced. Maps with high structural integrity, covering far more of the available literature, are presented.

  13. Cloning and expression of a widely expressed receptor tyrosine phosphatase

    DEFF Research Database (Denmark)

    Sap, J; D'Eustachio, P; Givol, D

    1990-01-01

    We describe the identification of a widely expressed receptor-type (transmembrane) protein tyrosine phosphatase (PTPase; EC 3.1.3.48). Screening of a mouse brain cDNA library under low-stringency conditions with a probe encompassing the intracellular (phosphatase) domain of the CD45 lymphocyte...... antigen yielded cDNA clones coding for a 794-amino acid transmembrane protein [hereafter referred to as receptor protein tyrosine phosphatase alpha (R-PTP-alpha)] with an intracellular domain displaying clear homology to the catalytic domains of CD45 and LAR (45% and 53%, respectively). The 142-amino acid...

  14. Area-wide traffic calming for preventing traffic related injuries.

    Science.gov (United States)

    Bunn, F; Collier, T; Frost, C; Ker, K; Roberts, I; Wentz, R

    2003-01-01

    It is estimated that by 2020 road traffic crashes will have moved from ninth to third in the world disease burden ranking, as measured in disability adjusted life years, and second in developing countries. The identification of effective strategies for the prevention of traffic related injuries is of global health importance. Area-wide traffic calming schemes that discourage through traffic on residential roads is one such strategy. To evaluate the effectiveness of area-wide traffic calming in preventing traffic related crashes, injuries, and deaths. We searched the following electronic databases: Cochrane Injuries Group's Specialised Register, Cochrane Controlled Trials Register, MEDLINE, EMBASE and TRANSPORT (NTIS, TRIS, TRANSDOC). We searched the web sites of road safety organisations, handsearched conference proceedings, checked reference lists of relevant papers and contacted experts in the area. The search was not restricted by language or publication status. Randomised controlled trials, and controlled before-after studies of area-wide traffic calming schemes. Two reviewers independently extracted data on type of study, characteristics of intervention and control areas, and length of data collection periods. Before and after data were collected on the total number of road traffic crashes, all road user deaths and injuries, pedestrian-motor vehicle collisions and road user deaths. The statistical package STATA was used to calculate rate ratios for each study, which were then pooled to give an overall estimate using a random effects model. We found no randomised controlled trials, but 16 controlled before-after trials met our inclusion criteria. Seven studies were done in Germany, six in the UK, two in Australia and one in the Netherlands. There were no studies in low or middle income countries. Eight trials reported the number of road traffic crashes resulting in deaths. The pooled rate ratio was 0.63 (0.14, 2.59 95% CI). Sixteen studies reported the number

  15. Inkjet-Printed Ultra Wide Band Fractal Antennas

    KAUST Repository

    Maza, Armando Rodriguez

    2012-05-01

    In this work, Paper-based inkjet-printed Ultra-wide band (UWB) fractal antennas are presented. Three new designs, a combined UWB fractal monopole based on the fourth order Koch Snowflake fractal which utilizes a Sierpinski Gasket fractal for ink reduction, a Cantor-based fractal antenna which performs a larger bandwidth compared to previously published UWB Cantor fractal monopole antenna, and a 3D loop fractal antenna which attains miniaturization, impedance matching and multiband characteristics. It is shown that fractals prove to be a successful method of reducing fabrication cost in inkjet printed antennas while retaining or enhancing printed antenna performance.

  16. A Wide Spectrum Neutron Polarizer for a Pulsed Neutron Source

    International Nuclear Information System (INIS)

    Nikitenko, Yu.V.

    1994-01-01

    A wide spectrum neutron polarizer for a pulsed neutron source is considered. The polarizer is made in a form of a set of magnetized mirrors placed on a drum. Homogeneous rotation of the polarizer is synchronized with the power pulses of the neutron source. The polarizer may be utilized in a collimated neutron beam with cross section of the order of magnitude of 100 cm 2 within a wavelength from 2 up to 20 A on sources with a pulse repetition frequency up to 50 Hz. (author). 5 refs.; 3 figs

  17. Business use of the World-Wide Web

    Directory of Open Access Journals (Sweden)

    C. Cockburn

    1995-01-01

    Full Text Available Two methods were employed in this study of the use of the World Wide Web by business: first, a sample of 300 businesses with Web sites, across a wide range of industry types, was examined, by selecting (rather than sampling companies from the Yahoo! directory. The sites were investigated in relation to several areas - the purpose of the Web site, the use being made of electronic mail and the extent to which multi-media was being utilised. In addition, any other aspects of the site which were designed to make it more interesting to potential customers were also noted. Secondly, an electronic-mail questionnaire was sent to 222 of the 300 companies surveyed: that is, those that provided an e-mail address for contact. 14 were returned immediately due to unknown addresses or technical problems. Of the remaining 208, 102 replies were received, five of which were of no relevance, leaving 97 completed questionnaires to examine; a response rate of 47%, which is surprisingly good for a survey of this kind.

  18. WFIRST: Astrometry with the Wide-Field Imager

    Science.gov (United States)

    Bellini, Andrea; WFIRST Astrometry Working Group

    2018-01-01

    The wide field of view and stable, sharp images delivered by WFIRST's Wide-Field Imager make it an excellent instrument for astrometry, one of five major discovery areas identified in the 2010 Decadal Survey. Compared to the Hubble Space Telescope, WFIRST's wider field of view with similar image quality will provide hundreds more astrometric targets per image as well as background galaxies and stars with precise positions in the Gaia catalog. In addition, WFIRST will operate in the infrared, a wavelength regime where the most precise astrometry has so far been achieved with adaptive optics images from large ground-based telescopes. WFIRST will provide at least a factor of three improvement in astrometry over the current state of the art in this wavelength range, while spanning a field of view thousands of times larger. WFIRST is thus poised to make major contributions to multiple science topics in which astrometry plays an important role, without major alterations to the planned mission or instrument. We summarize a few of the most compelling science cases where WFIRST astrometry could prove transformational.

  19. IDENTIFICATION OF WIDE COMPATIBILITY VARIETIES IN SOME TROPICAL JAPONICA RICE

    Directory of Open Access Journals (Sweden)

    A. Hairmansis

    2013-07-01

    Full Text Available The F1 hybrid sterility in indica/japonica crosses is the major barrier in developing hybrid rice varieties between these two diverse germplasm. The sterility problem in japonica/indica hybrids can be overcome by using wide compatibility genes. The objective of this study was to identify wide compatibility varieties (WCVs in some tropical japonica rice. Twenty five tropical japonica varieties as male parents were crossed with indica (IR64 and japonica (Akitakomachi testers as female parents. The crosses were planted following a randomized complete block design with three replications. Varieties having average spikelet fertility of more than 70% with both the indica and japonica testers were rated as WCVs. Result from this study showed that six tropical japonica varieties were classified as WCVs, i.e., Cabacu, Grogol, Kencana Bali, Klemas, Lampung Lawer, and Napa. Hybrid sterility is caused by partial sterility of male and female gametes. The WCVs from the present study can be used in hybrid rice breeding program to solve hybrid sterility in indica/japonica hybrids.

  20. Genome-wide association studies of obesity and metabolic syndrome.

    Science.gov (United States)

    Fall, Tove; Ingelsson, Erik

    2014-01-25

    Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were largely unknown, with the exception of a few forms of monogenic extreme obesity. Since genome-wide association studies (GWAS) became available, large advances have been made. The first single nucleotide polymorphism robustly associated with increased body mass index (BMI) was in 2007 mapped to a gene with for the time unknown function. This gene, now known as fat mass and obesity associated (FTO) has been repeatedly replicated in several ethnicities and is affecting obesity by regulating appetite. Since the first report from a GWAS of obesity, an increasing number of markers have been shown to be associated with BMI, other measures of obesity or fat distribution and metabolic syndrome. This systematic review of obesity GWAS will summarize genome-wide significant findings for obesity and metabolic syndrome and briefly give a few suggestions of what is to be expected in the next few years. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  1. Genome-wide mapping of DNA strand breaks.

    Directory of Open Access Journals (Sweden)

    Frédéric Leduc

    Full Text Available Determination of cellular DNA damage has so far been limited to global assessment of genome integrity whereas nucleotide-level mapping has been restricted to specific loci by the use of specific primers. Therefore, only limited DNA sequences can be studied and novel regions of genomic instability can hardly be discovered. Using a well-characterized yeast model, we describe a straightforward strategy to map genome-wide DNA strand breaks without compromising nucleotide-level resolution. This technique, termed "damaged DNA immunoprecipitation" (dDIP, uses immunoprecipitation and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin end-labeling (TUNEL to capture DNA at break sites. When used in combination with microarray or next-generation sequencing technologies, dDIP will allow researchers to map genome-wide DNA strand breaks as well as other types of DNA damage and to establish a clear profiling of altered genes and/or intergenic sequences in various experimental conditions. This mapping technique could find several applications for instance in the study of aging, genotoxic drug screening, cancer, meiosis, radiation and oxidative DNA damage.

  2. On-line plant-wide monitoring using neural networks

    International Nuclear Information System (INIS)

    Turkcan, E.; Ciftcioglu, O.; Eryurek, E.; Upadhyaya, B.R.

    1992-06-01

    The on-line signal analysis system designed for a multi-level mode operation using neural networks is described. The system is capable of monitoring the plant states by tracking different number of signals up to 32 simultaneously. The data used for this study were acquired from the Borssele Nuclear Power Plant (PWR type), and using the on-line monitoring system. An on-line plant-wide monitoring study using a multilayer neural network model is discussed in this paper. The back-propagation neural network algorithm is used for training the network. The technique assumes that each physical state of the power plant can be represented by a unique pattern of instrument readings which can be related to the condition of the plant. When disturbance occurs, the sensor readings undergo a transient, and form a different set of patterns which represent the new operational status. Diagnosing these patterns can be helpful in identifying this new state of the power plant. To this end, plant-wide monitoring with neutral networks is one of the new techniques in real-time applications. (author). 9 refs.; 5 figs

  3. A genome-wide association study of aging.

    Science.gov (United States)

    Walter, Stefan; Atzmon, Gil; Demerath, Ellen W; Garcia, Melissa E; Kaplan, Robert C; Kumari, Meena; Lunetta, Kathryn L; Milaneschi, Yuri; Tanaka, Toshiko; Tranah, Gregory J; Völker, Uwe; Yu, Lei; Arnold, Alice; Benjamin, Emelia J; Biffar, Reiner; Buchman, Aron S; Boerwinkle, Eric; Couper, David; De Jager, Philip L; Evans, Denis A; Harris, Tamara B; Hoffmann, Wolfgang; Hofman, Albert; Karasik, David; Kiel, Douglas P; Kocher, Thomas; Kuningas, Maris; Launer, Lenore J; Lohman, Kurt K; Lutsey, Pamela L; Mackenbach, Johan; Marciante, Kristin; Psaty, Bruce M; Reiman, Eric M; Rotter, Jerome I; Seshadri, Sudha; Shardell, Michelle D; Smith, Albert V; van Duijn, Cornelia; Walston, Jeremy; Zillikens, M Carola; Bandinelli, Stefania; Baumeister, Sebastian E; Bennett, David A; Ferrucci, Luigi; Gudnason, Vilmundur; Kivimaki, Mika; Liu, Yongmei; Murabito, Joanne M; Newman, Anne B; Tiemeier, Henning; Franceschini, Nora

    2011-11-01

    Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p < 5 × 10(-8)). We found 14 independent SNPs that predicted risk of death, and 8 SNPs that predicted event-free survival (p < 10(-5)). These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease. In addition to considerable overlap between the traits, pathway and network analysis corroborated these findings. These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Genome-Wide Expression Profiling of Complex Regional Pain Syndrome

    Science.gov (United States)

    Jin, Eun-Heui; Zhang, Enji; Ko, Youngkwon; Sim, Woo Seog; Moon, Dong Eon; Yoon, Keon Jung; Hong, Jang Hee; Lee, Won Hyung

    2013-01-01

    Complex regional pain syndrome (CRPS) is a chronic, progressive, and devastating pain syndrome characterized by spontaneous pain, hyperalgesia, allodynia, altered skin temperature, and motor dysfunction. Although previous gene expression profiling studies have been conducted in animal pain models, there genome-wide expression profiling in the whole blood of CRPS patients has not been reported yet. Here, we successfully identified certain pain-related genes through genome-wide expression profiling in the blood from CRPS patients. We found that 80 genes were differentially expressed between 4 CRPS patients (2 CRPS I and 2 CRPS II) and 5 controls (cut-off value: 1.5-fold change and pCRPS patients and 18 controls by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). We focused on the MMP9 gene that, by qRT-PCR, showed a statistically significant difference in expression in CRPS patients compared to controls with the highest relative fold change (4.0±1.23 times and p = 1.4×10−4). The up-regulation of MMP9 gene in the blood may be related to the pain progression in CRPS patients. Our findings, which offer a valuable contribution to the understanding of the differential gene expression in CRPS may help in the understanding of the pathophysiology of CRPS pain progression. PMID:24244504

  5. Concept definition of traffic flow wide-area surveillance

    Energy Technology Data Exchange (ETDEWEB)

    Allgood, G.O.; Ferrell, R.K.; Kercel, S.W.

    1994-07-01

    Traffic management can be thought of as a stochastic queuing process where the serving time at one of its control points is dynamically linked to the global traffic pattern, which is, in turn, dynamically linked to the control point. For this closed-loop system to be effective, the traffic management system must sense and interpret large spatial projections of data originating from multiple sensor suites. The intent of the Wide-Area Surveillance (WAS) Project is to build upon this concept and define the operational specifications and characteristics of a Traffic Flow Wide-Area Surveillance (TFWAS) system in terms of traffic management and control. In doing so, the functional capabilities of a TFWAS will be mapped onto an operational profile that is consistent with the Federal Highway Administration`s Intelligent Vehicle Highway System. This document provides the underlying foundation of this work by offering a concept definition for the TFWAS system. It concentrates on answering the question: ``What is the system?`` In doing so, the report develops a hierarchy of specialized definitions.

  6. Wide-bandgap epitaxial heterojunction windows for silicon solar cells

    Science.gov (United States)

    Landis, Geoffrey A.; Loferski, Joseph J.; Beaulieu, Roland; Sekula-Moise, Patricia A.; Vernon, Stanley M.

    1990-01-01

    It is shown that the efficiency of a solar cell can be improved if minority carriers are confined by use of a wide-bandgap heterojunction window. For silicon (lattice constant a = 5.43 A), nearly lattice-matched wide-bandgap materials are ZnS (a = 5.41 A) and GaP (a = 5.45 A). Isotype n-n heterojuntions of both ZnS/Si and GaP/Si were grown on silicon n-p homojunction solar cells. Successful deposition processes used were metalorganic chemical vapor deposition (MO-CVD) for GaP and ZnS, and vacuum evaporation of ZnS. Planar (100) and (111) and texture-etched - (111)-faceted - surfaces were used. A decrease in minority-carrier surface recombination compared to a bare surface was seen from increased short-wavelength spectral response, increased open-circuit voltage, and reduced dark saturation current, with no degradation of the minority carrier diffusion length.

  7. From Narrow to Wide Band Normalizer for LHC

    CERN Document Server

    Vismara, Giuseppe

    1997-01-01

    The narrow band normalizer (NBN) based on the phase processor is working to full satisfaction in the LEP BOM system for almost 10 years. Recently a new idea for a wide band normaliser (WBN) based on a time processor exploiting a single oscillation period has been developed. The position information is converted into a time difference between the zero crossing of two recombined and shaped electrode signals. It appears that the NBN can be easily adapted to perform as a wide band processor. To do so, the BP filter and the 90° Hybrid are replaced by low pass filter and delay lines. A prototype based on the present NBN has been developed and tested to prove the feasibility of the new idea. The paper gives an overview of the advantages and limitations of the BOM NB processor. It summarizes the useful LHC parameters and describes the specifications for the beam position acquisition system. After describing the basic principles, it analyzes in detail all the blocks of the processing chain and presents the measurem...

  8. Epigenome-Wide Association Study of Tic Disorders.

    Science.gov (United States)

    Zilhão, Nuno R; Padmanabhuni, Shanmukha S; Pagliaroli, Luca; Barta, Csaba; Smit, Dirk J A; Cath, Danielle; Nivard, Michel G; Baselmans, Bart M L; van Dongen, Jenny; Paschou, Peristera; Boomsma, Dorret I

    2015-12-01

    Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-(15)) developmental process (GO:0032502, p = 2.96 × 10(-12)), and cellular developmental process (GO:0048869, p = 1.96 × 10(-12)). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

  9. Genome-Wide Association Study of Antiphospholipid Antibodies

    Directory of Open Access Journals (Sweden)

    M. Ilyas Kamboh

    2013-01-01

    Full Text Available Background. The persistent presence of antiphospholipid antibodies (APA may lead to the development of primary or secondary antiphospholipid syndrome. Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown. In this study, we have performed a genome-wide association study (GWAS in an effort to identify susceptibility loci/genes for three main APA: anticardiolipin antibodies (ACL, lupus anticoagulant (LAC, and anti-β2 glycoprotein I antibodies (anti-β2GPI. Methods. DNA samples were genotyped using the Affymetrix 6.0 array containing 906,600 single-nucleotide polymorphisms (SNPs. Association of SNPs with the antibody status (positive/negative was tested using logistic regression under the additive model. Results. We have identified a number of suggestive novel loci with Pwide significance, many of the suggestive loci are potential candidates for the production of APA. We have replicated the previously reported associations of HLA genes and APOH with APA but these were not the top loci. Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings.

  10. Genomic research and wide data sharing: views of prospective participants.

    Science.gov (United States)

    Trinidad, Susan Brown; Fullerton, Stephanie M; Bares, Julie M; Jarvik, Gail P; Larson, Eric B; Burke, Wylie

    2010-08-01

    Sharing study data within the research community generates tension between two important goods: promoting scientific goals and protecting the privacy interests of study participants. This study was designed to explore the perceptions, beliefs, and attitudes of research participants and possible future participants regarding genome-wide association studies and repository-based research. Focus group sessions with (1) current research participants, (2) surrogate decision-makers, and (3) three age-defined cohorts (18-34 years, 35-50, >50). Participants expressed a variety of opinions about the acceptability of wide sharing of genetic and phenotypic information for research purposes through large, publicly accessible data repositories. Most believed that making de-identified study data available to the research community is a social good that should be pursued. Privacy and confidentiality concerns were common, although they would not necessarily preclude participation. Many participants voiced reservations about sharing data with for-profit organizations. Trust is central in participants' views regarding data sharing. Further research is needed to develop governance models that enact the values of stewardship.

  11. Genome-wide association study of Tourette Syndrome

    Science.gov (United States)

    Scharf, Jeremiah M.; Yu, Dongmei; Mathews, Carol A.; Neale, Benjamin M.; Stewart, S. Evelyn; Fagerness, Jesen A; Evans, Patrick; Gamazon, Eric; Edlund, Christopher K.; Service, Susan; Tikhomirov, Anna; Osiecki, Lisa; Illmann, Cornelia; Pluzhnikov, Anna; Konkashbaev, Anuar; Davis, Lea K; Han, Buhm; Crane, Jacquelyn; Moorjani, Priya; Crenshaw, Andrew T.; Parkin, Melissa A.; Reus, Victor I.; Lowe, Thomas L.; Rangel-Lugo, Martha; Chouinard, Sylvain; Dion, Yves; Girard, Simon; Cath, Danielle C; Smit, Jan H; King, Robert A.; Fernandez, Thomas; Leckman, James F.; Kidd, Kenneth K.; Kidd, Judith R.; Pakstis, Andrew J.; State, Matthew; Herrera, Luis Diego; Romero, Roxana; Fournier, Eduardo; Sandor, Paul; Barr, Cathy L; Phan, Nam; Gross-Tsur, Varda; Benarroch, Fortu; Pollak, Yehuda; Budman, Cathy L.; Bruun, Ruth D.; Erenberg, Gerald; Naarden, Allan L; Lee, Paul C; Weiss, Nicholas; Kremeyer, Barbara; Berrío, Gabriel Bedoya; Campbell, Desmond; Silgado, Julio C. Cardona; Ochoa, William Cornejo; Restrepo, Sandra C. Mesa; Muller, Heike; Duarte, Ana V. Valencia; Lyon, Gholson J; Leppert, Mark; Morgan, Jubel; Weiss, Robert; Grados, Marco A.; Anderson, Kelley; Davarya, Sarah; Singer, Harvey; Walkup, John; Jankovic, Joseph; Tischfield, Jay A.; Heiman, Gary A.; Gilbert, Donald L.; Hoekstra, Pieter J.; Robertson, Mary M.; Kurlan, Roger; Liu, Chunyu; Gibbs, J. Raphael; Singleton, Andrew; Hardy, John; Strengman, Eric; Ophoff, Roel; Wagner, Michael; Moessner, Rainald; Mirel, Daniel B.; Posthuma, Danielle; Sabatti, Chiara; Eskin, Eleazar; Conti, David V.; Knowles, James A.; Ruiz-Linares, Andres; Rouleau, Guy A.; Purcell, Shaun; Heutink, Peter; Oostra, Ben A.; McMahon, William; Freimer, Nelson; Cox, Nancy J.; Pauls, David L.

    2012-01-01

    Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel, and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (p<5 × 10−8); the top signal was found in rs7868992 on chromosome 9q32 within COL27A1 (p=1.85 × 10−6). A secondary analysis including an additional 211 cases and 285 controls from two closely-related Latin-American population isolates from the Central Valley of Costa Rica and Antioquia, Colombia also identified rs7868992 as the top signal (p=3.6 × 10−7 for the combined sample of 1496 cases and 5249 controls following imputation with 1000 Genomes data). This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder. PMID:22889924

  12. Mitigating fluorescence spectral overlap in wide-field endoscopic imaging

    Science.gov (United States)

    Hou, Vivian; Nelson, Leonard Y.; Seibel, Eric J.

    2013-01-01

    Abstract. The number of molecular species suitable for multispectral fluorescence imaging is limited due to the overlap of the emission spectra of indicator fluorophores, e.g., dyes and nanoparticles. To remove fluorophore emission cross-talk in wide-field multispectral fluorescence molecular imaging, we evaluate three different solutions: (1) image stitching, (2) concurrent imaging with cross-talk ratio subtraction algorithm, and (3) frame-sequential imaging. A phantom with fluorophore emission cross-talk is fabricated, and a 1.2-mm ultrathin scanning fiber endoscope (SFE) is used to test and compare these approaches. Results show that fluorophore emission cross-talk could be successfully avoided or significantly reduced. Near term, the concurrent imaging method of wide-field multispectral fluorescence SFE is viable for early stage cancer detection and localization in vivo. Furthermore, a means to enhance exogenous fluorescence target-to-background ratio by the reduction of tissue autofluorescence background is demonstrated. PMID:23966226

  13. Genome-Wide Association Study of Serum Selenium Concentrations

    Directory of Open Access Journals (Sweden)

    Ulrike Peters

    2013-05-01

    Full Text Available Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO Cancer Screening and the Women’s Health Initiative (WHI. We tested association between 2,474,333 single nucleotide polymorphisms (SNPs and serum selenium concentrations using linear regression models. In the first stage (PLCO 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003 in the second stage (WHI. Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11 and had p between 2.62 × 10−7 and 4.04 × 10−7 in the combined analysis (PLCO + WHI. Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

  14. Limiting photocurrent analysis of a wide channel photoelectrochemical flow reactor

    International Nuclear Information System (INIS)

    Davis, Jonathan T; Esposito, Daniel V

    2017-01-01

    The development of efficient and scalable photoelectrochemical (PEC) reactors is of great importance for the eventual commercialization of solar fuels technology. In this study, we systematically explore the influence of convective mass transport and light intensity on the performance of a 3D-printed PEC flow cell reactor based on a wide channel, parallel plate geometry. Using this design, the limiting current density generated from the hydrogen evolution reaction at a p-Si metal–insulator–semiconductor (MIS) photocathode was investigated under varied reactant concentration, fluid velocity, and light intensity. Additionally, a simple model is introduced to predict the range of operating conditions (reactant concentration, light intensity, fluid velocity) for which the photocurrent generated in a parallel plate PEC flow cell is limited by light absorption or mass transport. This model can serve as a useful guide for the design and operation of wide-channel PEC flow reactors. The results of this study have important implications for PEC reactors operating in electrolytes with dilute reactant concentrations and/or under high light intensities where high fluid velocities are required in order to avoid operation in the mass transport-limited regime. (paper)

  15. Marine: a new wide range neutron monitoring system concept

    Energy Technology Data Exchange (ETDEWEB)

    Trama, J.C.; Lescop, B.; Lefevre, J.; Nguyen, T.; Sudres, C. [CEA Saclay, 91 - Gif sur Yvette (France). Dept. d' Electronique et d' Instrumentation Nucleaire; Pasdeloup, P. [Technicatome, 13 - Les Milles (France)

    2001-07-01

    In a Nuclear Power Plant, the developed power is proportional to the emitted neutron flux. The 10 to 11 decades measurement range from source to power generally needs 3 distinct neutron measurement chains to be monitored. A wide range neutron monitoring system may cover this range with only one sensor followed by adequate electronics. In the past this concept has been developed with an analogue technology which was presenting some drawbacks (slow log amplifier, components perenniality). In this paper, we introduce a completely new design, that makes use of a recent technology, including full linear input electronics, and advanced digital signal processing. As far as the sensor is concerned, both a well known commercial fission chamber, or an innovative wide range sensor presenting a high sensitivity may be used. The basic concept is that the single signal is continuously processed by three different electronic stages, each one being dedicated to approximately one third of the full range: pulse, Campbelling and current modes. After amplification, appropriate shaping, this signal is numerically filtered by a Kalman filter algorithm to compute the neutron flux as well as the reactor period. A specifically developed test module allows the surveillance of the sensor and the electronics via stimuli injections and characteristic curves plotting. A computerised simulation of the whole chain is used to validate the signal processing algorithms evolutions. In the paper we will specifically develop the metrological performances of this chain and the general agreement that exists between simulated and measured values. (authors)

  16. Remote sensing education and Internet/World Wide Web technology

    Science.gov (United States)

    Griffith, J.A.; Egbert, S.L.

    2001-01-01

    Remote sensing education is increasingly in demand across academic and professional disciplines. Meanwhile, Internet technology and the World Wide Web (WWW) are being more frequently employed as teaching tools in remote sensing and other disciplines. The current wealth of information on the Internet and World Wide Web must be distilled, nonetheless, to be useful in remote sensing education. An extensive literature base is developing on the WWW as a tool in education and in teaching remote sensing. This literature reveals benefits and limitations of the WWW, and can guide its implementation. Among the most beneficial aspects of the Web are increased access to remote sensing expertise regardless of geographic location, increased access to current material, and access to extensive archives of satellite imagery and aerial photography. As with other teaching innovations, using the WWW/Internet may well mean more work, not less, for teachers, at least at the stage of early adoption. Also, information posted on Web sites is not always accurate. Development stages of this technology range from on-line posting of syllabi and lecture notes to on-line laboratory exercises and animated landscape flyovers and on-line image processing. The advantages of WWW/Internet technology may likely outweigh the costs of implementing it as a teaching tool.

  17. A Pooled Genome-Wide Association Study of Asperger Syndrome.

    Directory of Open Access Journals (Sweden)

    Varun Warrier

    Full Text Available Asperger Syndrome (AS is a neurodevelopmental condition characterized by impairments in social interaction and communication, alongside the presence of unusually repetitive, restricted interests and stereotyped behaviour. Individuals with AS have no delay in cognitive and language development. It is a subset of Autism Spectrum Conditions (ASC, which are highly heritable and has a population prevalence of approximately 1%. Few studies have investigated the genetic basis of AS. To address this gap in the literature, we performed a genome-wide pooled DNA association study to identify candidate loci in 612 individuals (294 cases and 318 controls of Caucasian ancestry, using the Affymetrix GeneChip Human Mapping version 6.0 array. We identified 11 SNPs that had a p-value below 1x10-5. These SNPs were independently genotyped in the same sample. Three of the SNPs (rs1268055, rs7785891 and rs2782448 were nominally significant, though none remained significant after Bonferroni correction. Two of our top three SNPs (rs7785891 and rs2782448 lie in loci previously implicated in ASC. However, investigation of the three SNPs in the ASC genome-wide association dataset from the Psychiatric Genomics Consortium indicated that these three SNPs were not significantly associated with ASC. The effect sizes of the variants were modest, indicating that our study was not sufficiently powered to identify causal variants with precision.

  18. Accessing NASA Technology with the World Wide Web

    Science.gov (United States)

    Nelson, Michael L.; Bianco, David J.

    1995-01-01

    NASA Langley Research Center (LaRC) began using the World Wide Web (WWW) in the summer of 1993, becoming the first NASA installation to provide a Center-wide home page. This coincided with a reorganization of LaRC to provide a more concentrated focus on technology transfer to both aerospace and non-aerospace industry. Use of WWW and NCSA Mosaic not only provides automated information dissemination, but also allows for the implementation, evolution and integration of many technology transfer and technology awareness applications. This paper describes several of these innovative applications, including the on-line presentation of the entire Technology OPportunities Showcase (TOPS), an industrial partnering showcase that exists on the Web long after the actual 3-day event ended. The NASA Technical Report Server (NTRS) provides uniform access to many logically similar, yet physically distributed NASA report servers. WWW is also the foundation of the Langley Software Server (LSS), an experimental software distribution system which will distribute LaRC-developed software. In addition to the more formal technology distribution projects, WWW has been successful in connecting people with technologies and people with other people.

  19. Gigwa-Genotype investigator for genome-wide analyses.

    Science.gov (United States)

    Sempéré, Guilhem; Philippe, Florian; Dereeper, Alexis; Ruiz, Manuel; Sarah, Gautier; Larmande, Pierre

    2016-06-06

    Exploring the structure of genomes and analyzing their evolution is essential to understanding the ecological adaptation of organisms. However, with the large amounts of data being produced by next-generation sequencing, computational challenges arise in terms of storage, search, sharing, analysis and visualization. This is particularly true with regards to studies of genomic variation, which are currently lacking scalable and user-friendly data exploration solutions. Here we present Gigwa, a web-based tool that provides an easy and intuitive way to explore large amounts of genotyping data by filtering it not only on the basis of variant features, including functional annotations, but also on genotype patterns. The data storage relies on MongoDB, which offers good scalability properties. Gigwa can handle multiple databases and may be deployed in either single- or multi-user mode. In addition, it provides a wide range of popular export formats. The Gigwa application is suitable for managing large amounts of genomic variation data. Its user-friendly web interface makes such processing widely accessible. It can either be simply deployed on a workstation or be used to provide a shared data portal for a given community of researchers.

  20. Geological problems in radioactive waste isolation - A world wide review

    Energy Technology Data Exchange (ETDEWEB)

    Witherspoon, P.A. [Lawrence Berkeley Lab., CA (United States)

    1991-06-01

    The problem of isolating radioactive wastes from the biosphere presents specialists in the earth sciences with some of the most complicated problems they have ever encountered. This is especially true for high-level waste (HLW), which must be isolated in the underground and away from the biosphere for thousands of years. The most widely accepted method of doing this is to seal the radioactive materials in metal canisters that are enclosed by a protective sheath and placed underground in a repository that has been carefully constructed in an appropriate rock formation. Much new technology is being developed to solve the problems that have been raised, and there is a continuing need to publish the results of new developments for the benefit of all concerned. Table 1 presents a summary of the various formations under investigation according to the reports submitted for this world wide review. It can be seen that in those countries that are searching for repository sites, granitic and metamorphic rocks are the prevalent rock type under investigation. Six countries have developed underground research facilities that are currently in use. All of these investigations are in saturated systems below the water table, except the United States project, which is in the unsaturated zone of a fractured tuff.

  1. Wide-area-distributed storage system for a multimedia database

    Science.gov (United States)

    Ueno, Masahiro; Kinoshita, Shigechika; Kuriki, Makato; Murata, Setsuko; Iwatsu, Shigetaro

    1998-12-01

    We have developed a wide-area-distribution storage system for multimedia databases, which minimizes the possibility of simultaneous failure of multiple disks in the event of a major disaster. It features a RAID system, whose member disks are spatially distributed over a wide area. Each node has a device, which includes the controller of the RAID and the controller of the member disks controlled by other nodes. The devices in the node are connected to a computer, using fiber optic cables and communicate using fiber-channel technology. Any computer at a node can utilize multiple devices connected by optical fibers as a single 'virtual disk.' The advantage of this system structure is that devices and fiber optic cables are shared by the computers. In this report, we first described our proposed system, and a prototype was used for testing. We then discussed its performance; i.e., how to read and write throughputs are affected by data-access delay, the RAID level, and queuing.

  2. A wide-bandwidth and high-sensitivity robust microgyroscope

    International Nuclear Information System (INIS)

    Sahin, Korhan; Sahin, Emre; Akin, Tayfun; Alper, Said Emre

    2009-01-01

    This paper reports a microgyroscope design concept with the help of a 2 degrees of freedom (DoF) sense mode to achieve a wide bandwidth without sacrificing mechanical and electronic sensitivity and to obtain robust operation against variations under ambient conditions. The design concept is demonstrated with a tuning fork microgyroscope fabricated with an in-house silicon-on-glass micromachining process. When the fabricated gyroscope is operated with a relatively wide bandwidth of 1 kHz, measurements show a relatively high raw mechanical sensitivity of 131 µV (° s −1 ) −1 . The variation in the amplified mechanical sensitivity (scale factor) of the gyroscope is measured to be less than 0.38% for large ambient pressure variations such as from 40 to 500 mTorr. The bias instability and angle random walk of the gyroscope are measured to be 131° h −1 and 1.15° h −1/2 , respectively

  3. Genome-wide association analyses of expression phenotypes.

    Science.gov (United States)

    Chen, Gary K; Zheng, Tian; Witte, John S; Goode, Ellen L; Gao, Lei; Hu, Pingzhao; Suh, Young Ju; Suktitipat, Bhoom; Szymczak, Silke; Woo, Jung Hoon; Zhang, Wei

    2007-01-01

    A number of issues arise when analyzing the large amount of data from high-throughput genotype and expression microarray experiments, including design and interpretation of genome-wide association studies of expression phenotypes. These issues were considered by contributions submitted to Group 1 of the Genetic Analysis Workshop 15 (GAW15), which focused on the association of quantitative expression data. These contributions evaluated diverse hypotheses, including those relevant to cancer and obesity research, and used various analytic techniques, many of which were derived from information theory. Several observations from these reports stand out. First, one needs to consider the genetic model of the trait of interest and carefully select which single nucleotide polymorphisms and individuals are included early in the design stage of a study. Second, by targeting specific pathways when analyzing genome-wide data, one can generate more interpretable results than agnostic approaches. Finally, for datasets with small sample sizes but a large number of features like the Genetic Analysis Workshop 15 dataset, machine learning approaches may be more practical than traditional parametric approaches. (c) 2007 Wiley-Liss, Inc.

  4. WorldWide Telescope Ambassadors, a Year 3 Update

    Science.gov (United States)

    Udomprasert, Patricia S.; Goodman, A. A.; Wong, C.

    2013-01-01

    The WorldWide Telescope Ambassadors (WWTA) Program has a track record of inspiring middle school students and getting them excited about science. The WorldWide Telescope (WWT) is a stunningly beautiful and freely available data visualization environment developed by Microsoft Research in collaboration with professional astronomers. Trained volunteer Ambassadors show teachers and students how to use WWT in their classrooms to explore and learn about our Universe. Our initial study has shown that WWT increases student understanding of astrophysical concepts and interest in astronomy and science. As an example of how excited students feel about learning astronomy with WWT, one middle school boy exclaimed, “This is way cooler than Call of Duty!” Our vision is to capitalize on the demonstrated inspirational and educational potential of WWT to increase the number of students who express interest in STEM fields. In this oral presentation, we provide a status update on the WWTA program, including ongoing results from our work with over 700 middle school students to date, and preliminary results from a new NSF-funded study comparing learning and interest gains for students studying Moon phases with WWT vs with the 2-dimensional simulator activity that accompanies their textbook. More information is available at wwtambassadors.org

  5. Magnetic systems for wide-aperture neutron polarizers and analyzers

    Energy Technology Data Exchange (ETDEWEB)

    Gilev, A.G. [Neutron Research Department, Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roscha, Gatchina, St. Petersburg 188300 (Russian Federation); Pleshanov, N.K., E-mail: pnk@pnpi.spb.ru [Neutron Research Department, Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roscha, Gatchina, St. Petersburg 188300 (Russian Federation); Bazarov, B.A.; Bulkin, A.P.; Schebetov, A.F. [Neutron Research Department, Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roscha, Gatchina, St. Petersburg 188300 (Russian Federation); Syromyatnikov, V.G. [Neutron Research Department, Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roscha, Gatchina, St. Petersburg 188300 (Russian Federation); Physical Department, St. Petersburg State University, Ulyanovskaya, 1, Petrodvorets, St. Petersburg 198504 (Russian Federation); Tarnavich, V.V.; Ulyanov, V.A. [Neutron Research Department, Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roscha, Gatchina, St. Petersburg 188300 (Russian Federation)

    2016-10-11

    Requirements on the field uniformity in neutron polarizers are analyzed in view of the fact that neutron polarizing coatings have been improved during the past decade. The design of magnetic systems that meet new requirements is optimized by numerical simulations. Magnetic systems for wide-aperture multichannel polarizers and analyzers are represented, including (a) the polarizer to be built at channel 4-4′ of the reactor PIK (Gatchina, Russia) for high-flux experiments with a 100×150 mm{sup 2} beam of polarized cold neutrons; (b) the fan analyzer covering a 150×100 mm{sup 2} window of the detector at the Magnetism Reflectometer (SNS, ORNL, USA); (c) the polarizer and (d) the fan analyzer covering a 220×110 mm{sup 2} window of the detector at the reflectometer NERO, which is transferred to PNPI (Russia) from HZG (Germany). Deviations of the field from the vertical did not exceed 2°. The polarizing efficiency of the analyzer at the Magnetism Reflectometer reached 99%, a record level for wide-aperture supermirror analyzers.

  6. Wide bandgap collector III-V double heterojunction bipolar transistors

    International Nuclear Information System (INIS)

    Flitcroft, R.M.

    2000-10-01

    This thesis is devoted to the study and development of Heterojunction Bipolar Transistors (HBTs) designed for high voltage operation. The work concentrates on the use of wide bandgap III-V semiconductor materials as the collector material and their associated properties influencing breakdown, such as impact ionisation coefficients. The work deals with issues related to incorporating a wide bandgap collector into double heterojunction structures such as conduction band discontinuities at the base-collector junction and results are presented which detail, a number of methods designed to eliminate the effects of such discontinuities. In particular the use of AlGaAs as the base material has been successful in eliminating the conduction band spike at this interface. A method of electrically injecting electrons into the collector has been employed to investigate impact ionisation in GaAs, GaInP and AlInP which has used the intrinsic gain of the devices to extract impact ionisation coefficients over a range of electric fields beyond the scope of conventional optical injection techniques. This data has enabled the study of ''dead space'' effects in HBT collectors and have been used to develop an analytical model of impact ionisation which has been incorporated into an existing Ebers-Moll HBT simulator. This simulator has been shown to accurately reproduce current-voltage characteristics in both the devices used in this work and for external clients. (author)

  7. The PEP-II/BaBar Project-Wide Database using World Wide Web and Oracle*Case

    International Nuclear Information System (INIS)

    Chan, A.; Crane, G.; MacGregor, I.; Meyer, S.

    1995-12-01

    The PEP-II/BaBar Project Database is a tool for monitoring the technical and documentation aspects of the accelerator and detector construction. It holds the PEP-II/BaBar design specifications, fabrication and installation data in one integrated system. Key pieces of the database include the machine parameter list, components fabrication and calibration data, survey and alignment data, property control, CAD drawings, publications and documentation. This central Oracle database on a UNIX server is built using Oracle*Case tools. Users at the collaborating laboratories mainly access the data using World Wide Web (WWW). The Project Database is being extended to link to legacy databases required for the operations phase

  8. Genome-wide association study of antisocial personality disorder

    Science.gov (United States)

    Rautiainen, M-R; Paunio, T; Repo-Tiihonen, E; Virkkunen, M; Ollila, H M; Sulkava, S; Jolanki, O; Palotie, A; Tiihonen, J

    2016-01-01

    The pathophysiology of antisocial personality disorder (ASPD) remains unclear. Although the most consistent biological finding is reduced grey matter volume in the frontal cortex, about 50% of the total liability to developing ASPD has been attributed to genetic factors. The contributing genes remain largely unknown. Therefore, we sought to study the genetic background of ASPD. We conducted a genome-wide association study (GWAS) and a replication analysis of Finnish criminal offenders fulfilling DSM-IV criteria for ASPD (N=370, N=5850 for controls, GWAS; N=173, N=3766 for controls and replication sample). The GWAS resulted in suggestive associations of two clusters of single-nucleotide polymorphisms at 6p21.2 and at 6p21.32 at the human leukocyte antigen (HLA) region. Imputation of HLA alleles revealed an independent association with DRB1*01:01 (odds ratio (OR)=2.19 (1.53–3.14), P=1.9 × 10-5). Two polymorphisms at 6p21.2 LINC00951–LRFN2 gene region were replicated in a separate data set, and rs4714329 reached genome-wide significance (OR=1.59 (1.37–1.85), P=1.6 × 10−9) in the meta-analysis. The risk allele also associated with antisocial features in the general population conditioned for severe problems in childhood family (β=0.68, P=0.012). Functional analysis in brain tissue in open access GTEx and Braineac databases revealed eQTL associations of rs4714329 with LINC00951 and LRFN2 in cerebellum. In humans, LINC00951 and LRFN2 are both expressed in the brain, especially in the frontal cortex, which is intriguing considering the role of the frontal cortex in behavior and the neuroanatomical findings of reduced gray matter volume in ASPD. To our knowledge, this is the first study showing genome-wide significant and replicable findings on genetic variants associated with any personality disorder. PMID:27598967

  9. Technology Development for 3-D Wide Swath Imaging Supporting ACE

    Science.gov (United States)

    Racette, Paul; Heymsfield, Gerry; Li, Lihua; Mclinden, Matthew; Park, Richard; Cooley, Michael; Stenger, Pete; Hand, Thomas

    2014-01-01

    The National Academy of Sciences Decadal Survey (DS) Aerosol-Cloud-Ecosystems Mission (ACE) aims to advance our ability to observe and predict changes to the Earth's hydrological cycle and energy balance in response to climate forcing, especially those changes associated with the effects of aerosol on clouds and precipitation. ACE is focused on obtaining measurements to reduce the uncertainties in current climate models arising from the lack in understanding of aerosol-cloud interactions. As part of the mission instrument suite, a dual-frequency radar comprised of a fixed-beam 94 gigahertz (W-band) radar and a wide-swath 35 gigahertz (Ka-band) imaging radar has been recommended by the ACE Science Working Group.In our 2010 Instrument Incubator Program project, we've developed a radar architecture that addresses the challenge associated with achieving the measurement objectives through an innovative, shared aperture antenna that allows dual-frequency radar operation while achieving wide-swath (100 kilometers) imaging at Ka-band. The antenna system incorporates 2 key technologies; a) a novel dual-band reflectorreflectarray and b) a Ka-band Active Electronically Scanned Array (AESA) feed module. The dual-band antenna is comprised of a primary cylindrical reflectorreflectarray surface illuminated by a point-focus W-band feed (compatible with a quasi-optical beam waveguide feed, such as that employed on CloudSat); the Ka-band AESA line feed provides wide-swath across-track scanning. The benefits of this shared-aperture approach include significant reductions in ACE satellite payload size, weight, and cost, as compared to a two aperture approach. Four objectives were addressed in our project. The first entailed developing the tools for the analysis and design of reflectarray antennas, assessment of candidate reflectarray elements, and validation using test coupons. The second objective was to develop a full-scale aperture design utilizing the reflectarray surface and to

  10. An information filtering system prototype for world wide web; Prototipo di sistema di information filtering per world wide web

    Energy Technology Data Exchange (ETDEWEB)

    Bordoni, L. [ENEA Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Funzione Centrale Studi

    1999-07-01

    In this report the architecture of an information filtering system for world wide web, developed by the Rome Third University (Italy) for ENEA (National Agency for New Technology, Energy and the Environment), is described. This prototype allows for selecting documents in text/HTML format from the web according to the interests of users. A user modeling shell allows ro build a model of user's interests, obtained during the interaction. The experimental results support the choice of embedding methods for this kind of application. [Italian] In questo rapporto viene descritta l'architettura di un sistema adattivo di information filtering su world wide web, sviluppato dall'universita' di Roma III in collaborazione con l'ENEA. Il prototipo descritto e' in grado di selezionare documenti in formato testo/html, raccolti dal web, in accordo con le caratteristiche e gli interessi degli utenti. Una shell di modellazione utente consente di costruire un modello degli interessi dell'utente, ottenuto nel corso dell'interazione. I risultati sperimentali rafforzano la scelta di usare metodi di modellazione utente per questo genere di applicazioni.

  11. An information filtering system prototype for world wide web; Prototipo di sistema di information filtering per world wide web

    Energy Technology Data Exchange (ETDEWEB)

    Bordoni, L [ENEA Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Funzione Centrale Studi

    1999-07-01

    In this report the architecture of an information filtering system for world wide web, developed by the Rome Third University (Italy) for ENEA (National Agency for New Technology, Energy and the Environment), is described. This prototype allows for selecting documents in text/HTML format from the web according to the interests of users. A user modeling shell allows ro build a model of user's interests, obtained during the interaction. The experimental results support the choice of embedding methods for this kind of application. [Italian] In questo rapporto viene descritta l'architettura di un sistema adattivo di information filtering su world wide web, sviluppato dall'universita' di Roma III in collaborazione con l'ENEA. Il prototipo descritto e' in grado di selezionare documenti in formato testo/html, raccolti dal web, in accordo con le caratteristiche e gli interessi degli utenti. Una shell di modellazione utente consente di costruire un modello degli interessi dell'utente, ottenuto nel corso dell'interazione. I risultati sperimentali rafforzano la scelta di usare metodi di modellazione utente per questo genere di applicazioni.

  12. On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

    Directory of Open Access Journals (Sweden)

    Petersen Ann-Kristin

    2012-06-01

    Full Text Available Abstract Background Genome-wide association studies (GWAS with metabolic traits and metabolome-wide association studies (MWAS with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to the etiology of complex diseases. Hypothesis-free testing of ratios between all possible metabolite pairs in GWAS and MWAS has proven to be an innovative approach in the discovery of new biologically meaningful associations. The p-gain statistic was introduced as an ad-hoc measure to determine whether a ratio between two metabolite concentrations carries more information than the two corresponding metabolite concentrations alone. So far, only a rule of thumb was applied to determine the significance of the p-gain. Results Here we explore the statistical properties of the p-gain through simulation of its density and by sampling of experimental data. We derive critical values of the p-gain for different levels of correlation between metabolite pairs and show that B/(2*α is a conservative critical value for the p-gain, where α is the level of significance and B the number of tested metabolite pairs. Conclusions We show that the p-gain is a well defined measure that can be used to identify statistically significant metabolite ratios in association studies and provide a conservative significance cut-off for the p-gain for use in future association studies with metabolic traits.

  13. Genome-wide comparative analysis of four Indian Drosophila species.

    Science.gov (United States)

    Mohanty, Sujata; Khanna, Radhika

    2017-12-01

    Comparative analysis of multiple genomes of closely or distantly related Drosophila species undoubtedly creates excitement among evolutionary biologists in exploring the genomic changes with an ecology and evolutionary perspective. We present herewith the de novo assembled whole genome sequences of four Drosophila species, D. bipectinata, D. takahashii, D. biarmipes and D. nasuta of Indian origin using Next Generation Sequencing technology on an Illumina platform along with their detailed assembly statistics. The comparative genomics analysis, e.g. gene predictions and annotations, functional and orthogroup analysis of coding sequences and genome wide SNP distribution were performed. The whole genome of Zaprionus indianus of Indian origin published earlier by us and the genome sequences of previously sequenced 12 Drosophila species available in the NCBI database were included in the analysis. The present work is a part of our ongoing genomics project of Indian Drosophila species.

  14. Wide Panel Testing Technique for Evaluating Repair Weld Strengths

    Science.gov (United States)

    Rogers, Patrick R.; Bynum, Julian E.; Shah, Sandeep R.

    1998-01-01

    This paper describes a new tensile testing technique for evaluating the overall effect of a repair weld on the strength of a welded joint. Previously, repair weld strengths have been evaluated using one-inch width tensile specimens, but this technique does not capture all of the effects that result from a repair. The new technique involves testing of "wide panel" tensile specimens which contain the full length of a repair weld within a longer initial weld, allowing the specimen to capture the combined effects of residual stresses, local strength degradation, and load redistribution around a repair. The development of strains in the repair area of standard aluminum alloy specimens and new high-performance aluminum-lithium alloy specimens was observed and evaluated using photoelastic material. The results of this evaluation show an increased sensitivity to repair welding residual stresses in the aluminum-lithium alloy specimens.

  15. Genomic selection: genome-wide prediction in plant improvement.

    Science.gov (United States)

    Desta, Zeratsion Abera; Ortiz, Rodomiro

    2014-09-01

    Association analysis is used to measure relations between markers and quantitative trait loci (QTL). Their estimation ignores genes with small effects that trigger underpinning quantitative traits. By contrast, genome-wide selection estimates marker effects across the whole genome on the target population based on a prediction model developed in the training population (TP). Whole-genome prediction models estimate all marker effects in all loci and capture small QTL effects. Here, we review several genomic selection (GS) models with respect to both the prediction accuracy and genetic gain from selection. Phenotypic selection or marker-assisted breeding protocols can be replaced by selection, based on whole-genome predictions in which phenotyping updates the model to build up the prediction accuracy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Sharing waste management data over a wide area computer network

    International Nuclear Information System (INIS)

    Menke, W.; Friberg, P.

    1992-01-01

    In this paper the authors envision a time when waste management professionals from any institution will be able to access high quality data, regardless of where this data may actually be archived. They will not have to know anything about where the data actually resides or what format it is stored in. They will only have to specify the type of data and the workstation software will handle the rest of the details of finding them and accessing them. A method - now in use at the Lamont-Doherty Geological Observatory of Columbia University and several other institutions - of achieving this vision is described in this paper. Institutions make views of their databases publicly available to users of the wide-area network (e.g. Internet), using database serving software that runs on one of their computers. This software completely automates the process of finding out what kind of data are available and of retrieving them

  17. Ultra Wide Band RFID Neutron Tags for Nuclear Materials Monitoring

    International Nuclear Information System (INIS)

    Nekoogar, F.; Dowla, F.; Wang, T.

    2010-01-01

    Recent advancements in the ultra-wide band Radio Frequency Identification (RFID) technology and solid state pillar type neutron detectors have enabled us to move forward in combining both technologies for advanced neutron monitoring. The LLNL RFID tag is totally passive and will operate indefinitely without the need for batteries. The tag is compact, can be directly mounted on metal, and has high performance in dense and cluttered environments. The LLNL coin-sized pillar solid state neutron detector has achieved a thermal neutron detection efficiency of 20% and neutron/gamma discrimination of 1E5. These performance values are comparable to a fieldable 3 He based detector. In this paper we will discuss features about the two technologies and some potential applications for the advanced safeguarding of nuclear materials.

  18. JR-curves of wide plates and CT25 specimens

    International Nuclear Information System (INIS)

    Aurich, D.; Wobst, K.; Krafka, H.

    1987-01-01

    In connection with the problem of the applicability of the characteristic specimen date - i.e. the initiation and stable crack propagation under maximal loads, together with the elastic-plastic material behaviour - to that of actual components, spot-check type beside tests were conducted using wide-plate central crack, central notch (CCT, CNT) and double external crack (DECT) samples. The material in question was an StE 460 steel. A comparison between the determined values shows that the assessed pressure vessel behaviour differs extensively to the values derived from the CCT and CNT specimens. The corresponding results obtained from the CT25 and DECT specimens vary only slightly in the region of interest and correspond to real vessel values. (orig./DG) [de

  19. Biosurfactant-producing yeasts widely inhabit various vegetables and fruits.

    Science.gov (United States)

    Konishi, Masaaki; Maruoka, Naruyuki; Furuta, Yoshifumi; Morita, Tomotake; Fukuoka, Tokuma; Imura, Tomohiro; Kitamoto, Dai

    2014-01-01

    The isolation of biosurfactant-producing yeasts from food materials was accomplished. By a combination of a new drop collapse method and thin-layer chromatography, 48 strains were selected as glycolipid biosurfactant producers from 347 strains, which were randomly isolated from various vegetables and fruits. Of the producers, 69% were obtained from vegetables of the Brassica family. Of the 48 producers, 15 strains gave relatively high yields of mannosylerythritol lipids (MELs), and were identified as Pseudozyma yeasts. These strains produced MELs from olive oil at yields ranging from 8.5 to 24.3 g/L. The best yield coefficient reached 0.49 g/g as to the carbon sources added. Accordingly, MEL producers were isolated at high efficiency from various vegetables and fruits, indicating that biosurfactant producers are widely present in foods. The present results should facilitate their application in the food and related industries.

  20. Cobalt catalyzed hydroesterification of a wide range of olefins

    Energy Technology Data Exchange (ETDEWEB)

    Van Rensburg, H.; Hanton, M.; Tooze, R.P.; Foster, D.F. [Sasol Technology UK, St Andrews (United Kingdom)

    2011-07-01

    Petrochemical raw materials are an essential raw material for the production of detergents with a substantial portion of synthetic fatty alcohols being produced via hydroformylation of oil or coal derived olefins. Carbonylation processes other than hydroformylation have to date not been commercially employed for the production of fatty esters or alcohols. In this document we highlight the opportunities of converting olefins to esters using cobalt catalyzed alkoxycarbonylation. This process is highly versatile and applicable to a wide range of olefins, linear or branched, alpha or internal in combination with virtually any chain length primary or secondary alcohol allowing the synthesis of a diverse array of compounds such as ester ethoxylated surfactants, methyl branched detergents, lubricants and alkyl propanoates. Furthermore, alkoxycarbonylation of a broad olefin/paraffin hydrocarbon range could be used to produce the corresponding broad cut detergent alcohols. (orig.)

  1. Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

    DEFF Research Database (Denmark)

    Dijkstra, Akkelies E; Smolonska, Joanna; van den Berge, Maarten

    2014-01-01

    by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism...... (SNP). RESULTS: A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10(-6), OR = 1.17), located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1) on chromosome 3. The risk allele (G) was associated with higher mRNA expression...... of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations. METHODS: GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed...

  2. A GPU-Based Wide-Band Radio Spectrometer

    Science.gov (United States)

    Chennamangalam, Jayanth; Scott, Simon; Jones, Glenn; Chen, Hong; Ford, John; Kepley, Amanda; Lorimer, D. R.; Nie, Jun; Prestage, Richard; Roshi, D. Anish; Wagner, Mark; Werthimer, Dan

    2014-12-01

    The graphics processing unit has become an integral part of astronomical instrumentation, enabling high-performance online data reduction and accelerated online signal processing. In this paper, we describe a wide-band reconfigurable spectrometer built using an off-the-shelf graphics processing unit card. This spectrometer, when configured as a polyphase filter bank, supports a dual-polarisation bandwidth of up to 1.1 GHz (or a single-polarisation bandwidth of up to 2.2 GHz) on the latest generation of graphics processing units. On the other hand, when configured as a direct fast Fourier transform, the spectrometer supports a dual-polarisation bandwidth of up to 1.4 GHz (or a single-polarisation bandwidth of up to 2.8 GHz).

  3. Protyping machine vision software on the World Wide Web

    Science.gov (United States)

    Karantalis, George; Batchelor, Bruce G.

    1998-10-01

    Interactive image processing is a proven technique for analyzing industrial vision applications and building prototype systems. Several of the previous implementations have used dedicated hardware to perform the image processing, with a top layer of software providing a convenient user interface. More recently, self-contained software packages have been devised and these run on a standard computer. The advent of the Java programming language has made it possible to write platform-independent software, operating over the Internet, or a company-wide Intranet. Thus, there arises the possibility of designing at least some shop-floor inspection/control systems, without the vision engineer ever entering the factories where they will be used. It successful, this project will have a major impact on the productivity of vision systems designers.

  4. Nation-Wide Mobile Network Energy Evolution Analysis

    DEFF Research Database (Denmark)

    Perez, Eva; Frank, Philipp; Micallef, Gilbert

    2013-01-01

    Mobile network operators are facing a challenging dilemma. While on the one hand they are committed to reducing their carbon emissions, and energy consumption, they are also required to continuously upgrade existing networks, ensuring that the relentless growth in data traffic can still be suppor......Mobile network operators are facing a challenging dilemma. While on the one hand they are committed to reducing their carbon emissions, and energy consumption, they are also required to continuously upgrade existing networks, ensuring that the relentless growth in data traffic can still...... be supported. In most cases, these upgrades increase the energy consumption of the network even further. This paper presents a nation-wide case study, based on a commercial network of a leading European operator, intended to provide a clear understanding of how the energy consumption of mobile networks...... is expected to evolve from 2012 until 2020. The study also considers an efficient network capacity evolution path, including base station equipment improvement forecasts....

  5. Genome-wide transcriptional reprogramming under drought stress

    KAUST Repository

    Chen, Hao

    2012-01-01

    Soil water deficit is one of the major factors limiting plant productivity. Plants cope with this adverse environmental condition by coordinating the up- or downregulation of an array of stress responsive genes. Reprogramming the expression of these genes leads to rebalanced development and growth that are in concert with the reduced water availability and that ultimately confer enhanced stress tolerance. Currently, several techniques have been employed to monitor genome-wide transcriptional reprogramming under drought stress. The results from these high throughput studies indicate that drought stress-induced transcriptional reprogramming is dynamic, has temporal and spatial specificity, and is coupled with the circadian clock and phytohormone signaling pathways. © 2012 Springer-Verlag Berlin Heidelberg. All rights are reserved.

  6. First operation of the wide-area remote experiment system

    International Nuclear Information System (INIS)

    Furukawa, Y.; Hasegawa, K.; Ueno, G.

    2012-01-01

    The Wide-area Remote Experiment System (WRES) at Spring-8 has been successfully developed. The system communicates with remote users on the basis of SSL/TLS with bi-directional authentication to avoid interference from unauthorized access to the system. The system has a message-filtering system to allow remote users access only to the corresponding beamline equipment and safety interlock system. This is to protect persons inside the experimental station from injury from any accidental motion of heavy equipment. The system also has a video streaming system to monitor samples or experimental equipment. We have tested the system from the point of view of safety, stability, reliability etc. and successfully performed the first experiment from a remote site, i.e., RIKEN's Wako campus, which is 480 km away from Spring-8, at the end of October 2010. (authors)

  7. Honeywell's Compact, Wide-angle Uv-visible Imaging Sensor

    Science.gov (United States)

    Pledger, D.; Billing-Ross, J.

    1993-01-01

    Honeywell is currently developing the Earth Reference Attitude Determination System (ERADS). ERADS determines attitude by imaging the entire Earth's limb and a ring of the adjacent star field in the 2800-3000 A band of the ultraviolet. This is achieved through the use of a highly nonconventional optical system, an intensifier tube, and a mega-element CCD array. The optics image a 30 degree region in the center of the field, and an outer region typically from 128 to 148 degrees, which can be adjusted up to 180 degrees. Because of the design employed, the illumination at the outer edge of the field is only some 15 percent below that at the center, in contrast to the drastic rolloffs encountered in conventional wide-angle sensors. The outer diameter of the sensor is only 3 in; the volume and weight of the entire system, including processor, are 1000 cc and 6 kg, respectively.

  8. Jet disruption in wide-angle tailed radio galaxies

    International Nuclear Information System (INIS)

    Burns, J.O.; Norman, M.L.; Clarke, D.A.

    1986-01-01

    The mechanisms responsible for the bending of the jets and tails of wide-angle tailed (WAT) radio galaxies in clusters are investigated theoretically, with a focus on sharp bends and rapid jet disruption. Large (1 Mpc) and small (200 kpc) WATs are differentiated, and it is suggested that the jet-tail transition in large WATs is due to collisions between the jet and cool clouds of the intracluster medium (ICM). The transition in small WATs is attributed to the passage of the jet through a planar Mach disk perpendicular to the jet flow direction. Such a disk is shown in numerical simulations to form when there is a shocklike jump in ambient pressure at the ISM/ICM interface; the origins of such a jump are explored. 14 references

  9. A wide range and high speed automatic gain control

    International Nuclear Information System (INIS)

    Tacconi, E.; Christiansen, C.

    1993-05-01

    Automatic gain control (AGC) techniques have been largely used since the beginning of electronics, but in most of the applications the dynamic response is slow compared with the carrier frequency. The problem of developing an automatic gain control with high dynamic response and wide control range simultaneously is analyzed in this work. An ideal gain control law, with the property that the total loop gain remains constant independent of the carrier amplitude, is obtained. The resulting AGC behavior is compared by computer simulations with a linear multiplier AGC. The ideal gain control law can be approximated using a transconductance amplifier. A practical circuit that has been used at CERN in the radio frequency loops of the Booster Synchrotron is presented. The circuit has high speed and 80-dB gain control range

  10. Corn rootworm area-wide management across the United States

    International Nuclear Information System (INIS)

    Chandler, Laurence D.; Coppedge, James R.; Richard Edwards, C.; Tollefson, Jon J.; Wilde, Gerald E.

    2000-01-01

    The western corn rootworm, Diabrotica virgifera virgifera LeConte, northern corn rootworm, D. barberi Smith and Lawrence, and Mexican corn rootworm, D. virgifera zeae Krysan and Smith are among the most economically and environmentally important pests of United States maize (Zea mays L.) production systems (Metcalf 1986). Annually, 8 to 10 million hectares of maize are treated with soil applied insecticides to protect the crop from larval feeding damage. Crop rotation, however, is also widely used to minimise the need for soil insecticide applications. Insecticides for adult rootworm management are also frequently used. Numerous problems are currently associated with corn rootworm management approaches. Soil insecticides are normally used to protect maize roots from larval feeding damage. However, they are ineffective in controlling the management of corn rootworm populations (Gray et al. 1992, Sutter et al. 1991). It is not uncommon for large numbers of rootworms to develop within treated fields. Thus, when maize is grown in the same field year after year (continuous cropping), soil insecticide applications must be used to protect the plant. These applications are generally made without knowledge (prophylactic) of the rootworm population levels within the field due to the difficulty of sampling for immature life stages. Western corn rootworm resistance to chlorinated hydrocarbon insecticides has been extensively documented (Ball and Weekman 1962). Recently, two distinct populations of western corn rootworms in Nebraska were found to be resistant to carbaryl and methyl parathion which are commonly used for adult control (Meinke et al. 1998). Although the occurrence of resistance has not spread outside of these areas, the potential for increased tolerance of western corn rootworm populations to carbamate and organophosphate insecticides across the region does exist. In response to many of the management problems discussed above, scientists with the USDA Agricultural

  11. High frequency modulation circuits based on photoconductive wide bandgap switches

    Science.gov (United States)

    Sampayan, Stephen

    2018-02-13

    Methods, systems, and devices for high voltage and/or high frequency modulation. In one aspect, an optoelectronic modulation system includes an array of two or more photoconductive switch units each including a wide bandgap photoconductive material coupled between a first electrode and a second electrode, a light source optically coupled to the WBGP material of each photoconductive switch unit via a light path, in which the light path splits into multiple light paths to optically interface with each WBGP material, such that a time delay of emitted light exists along each subsequent split light path, and in which the WBGP material conducts an electrical signal when a light signal is transmitted to the WBGP material, and an output to transmit the electrical signal conducted by each photoconductive switch unit. The time delay of the photons emitted through the light path is substantially equivalent to the time delay of the electrical signal.

  12. Wide Range Portable Radiation Survey Meter for Emergency Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Gangadharan, P.; Bhave, D. G.; Gokarn, R. S.; Khadake, R. G. [Directorate Of Radiation Protection, Bhabha Atomic Research Centre, Trombay, Bombay (India)

    1969-05-15

    The paper describes a portable battery-operated radiation survey meter for monitoring a wide range of X- and gamma-ray exposure rates from 1 mR/h to 100 R/h. The instrument Incorporates a halogen GM tube as the detector and a count-rate meter for indication. A transistorized d.c. -d.c. converter supplies the necessary high voltage to the GM counter. The instrument response has been made energy independent in the energy range 80 keV to 1.25 MeV. Further, the response is linear over the entire range of exposure rates. Suitable extension rods have been designed to provide sufficient separation between the probe and the meter in cases where remote monitoring is necessary because of high fields. (author)

  13. Update on wide- and ultra-widefield retinal imaging

    Directory of Open Access Journals (Sweden)

    Samir S Shoughy

    2015-01-01

    Full Text Available The peripheral retina is the site of pathology in many ocular diseases and ultra-widefield (UWF imaging is one of the new technologies available to ophthalmologists to manage some of these diseases. Currently, there are several imaging systems used in practice for the purpose of diagnostic, monitoring disease progression or response to therapy, and telemedicine. These include modalities for both adults and pediatric patients. The current systems are capable of producing wide- and UWF color fundus photographs, fluorescein and indocyanine green angiograms, and autofluorescence images. Using this technology, important clinical observations have been made in diseases such as diabetic retinopathy, uveitides, retinal vascular occlusions and tumors, intraocular tumors, retinopathy of prematurity, and age-related macular degeneration. Widefield imaging offers excellent postoperative documentation of retinal detachment surgery. New applications will soon be available to integrate this technology into large volume routine clinical practice.

  14. New Class of Wide Energy Gap Benzotriimidazole Optical Materials

    Directory of Open Access Journals (Sweden)

    Jianmin Shi

    2017-10-01

    Full Text Available A new class of wide energy gap benzotriimidazole materials have been synthesized by a two-step condensation reaction. All of the benzotriimidazole compounds have π-π* absorption bands in the range of 250–400 nm. The photoluminescence (PL quantum efficiency of each benzotriimidazole depends strongly on the presence of electron withdrawing groups. PL quantum efficiencies of benzotriimidazoles without electron withdrawing groups were less than desirable (40–43%, while molecules with electron withdrawing groups displayed much stronger PL with efficiencies in the range of 73–75%. The electron withdrawing groups shift the emission to a longer wavelength, towards a more “true blue” color. This new class of benzotriimidazole optical materials could be used as electron-injecting and electron-transporting blue luminescence materials for potential organic light-emitting diode (OLED applications.

  15. Brain-wide neuronal dynamics during motor adaptation in zebrafish.

    Science.gov (United States)

    Ahrens, Misha B; Li, Jennifer M; Orger, Michael B; Robson, Drew N; Schier, Alexander F; Engert, Florian; Portugues, Ruben

    2012-05-09

    A fundamental question in neuroscience is how entire neural circuits generate behaviour and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to record the activity of large populations of neurons at the cellular level, throughout the brain of larval zebrafish expressing a genetically encoded calcium sensor, while the paralysed animals interact fictively with a virtual environment and rapidly adapt their motor output to changes in visual feedback. We decompose the network dynamics involved in adaptive locomotion into four types of neuronal response properties, and provide anatomical maps of the corresponding sites. A subset of these signals occurred during behavioural adjustments and are candidates for the functional elements that drive motor learning. Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-cell resolution during behaviour.

  16. Affordable Digital Planetariums with WorldWide Telescope

    Science.gov (United States)

    Rosenfield, P.; Connolly, A.; Fay, J.; Sayres, C.; Tofflemire, B.

    2011-09-01

    Digital planetariums can provide a broader range of educational experiences than the more classical planetariums that use star-balls. This is because of their ability to project images, content from current research, and the 3-D distribution of the stars and galaxies. While there are hundreds of planetariums in the country, the reason that few of these are fully digital is the cost. In collaboration with Microsoft Research (MSR), we have developed a way to digitize existing planetariums for approximately $40,000 using freely available software. We describe here how off the shelf equipment, together with a WorldWide Telescope client, can provide a rich and truly interactive experience. This will enable students and the public to pan though multi-wavelength full-sky scientific data sets, explore 3-D visualizations of our Solar System (including trajectories of millions of minor planets), near-by stars, and the SDSS galaxy catalog.

  17. Designing and implementing a trust-wide quality assurance programme.

    Science.gov (United States)

    Coope, Sally-Ann

    2018-04-02

    Derbyshire Community Health Services (DCHS) NHS Foundation Trust provides a wide range of community-based health services. After the Care Quality Commission (CQC) found gaps in the trust's assurance process, its board decided to develop a method of continuous quality improvements that could be used as a basis for the trust's quality assurance system. The trust adapted and built on an acute model so it was suitable for community services. The final assurance system, Quality Always, has four elements: the clinical assessment and accreditation scheme; leadership development; 'champions' within clinical teams to support and promote the scheme; and dashboards to record and monitor progress. A system to recognise and reward achievement was essential for success. Quality Always has resulted in better care quality, an improved CQC rating, a sense of achievement among staff, the development of support networks, learning (especially among support staff) and good practice being shared.

  18. Wide area methane emissions mapping with airborne IPDA lidar

    Science.gov (United States)

    Bartholomew, Jarett; Lyman, Philip; Weimer, Carl; Tandy, William

    2017-08-01

    Methane emissions from natural gas production, storage, and transportation are potential sources of greenhouse gas emissions. Methane leaks also constitute revenue loss potential from operations. Since 2013, Ball Aerospace has been developing advanced airborne sensors using integrated path differential absorption (IPDA) LIDAR instrumentation to identify methane, propane, and longer-chain alkanes in the lowest region of the atmosphere. Additional funding has come from the U.S. Department of Transportation, Pipeline and Hazardous Materials Administration (PHMSA) to upgrade instrumentation to a broader swath coverage of up to 400 meters while maintaining high spatial sampling resolution and geolocation accuracy. Wide area coverage allows efficient mapping of emissions from gathering and distribution networks, processing facilities, landfills, natural seeps, and other distributed methane sources. This paper summarizes the benefits of advanced instrumentation for aerial methane emission mapping, describes the operating characteristics and design of this upgraded IPDA instrumentation, and reviews technical challenges encountered during development and deployment.

  19. Plate-wide stress relaxation explains European Palaeocene basin inversions

    DEFF Research Database (Denmark)

    Nielsen, S.B.; Thomsen, Erik; Hansen, D.L.

    2005-01-01

    of the in-plane tectonic stress. The onset of relaxation inversions was plate-wide and simultaneous, and may have been triggered by stress changes caused by elevation of the North Atlantic lithosphere by the Iceland plume or the drop in NS convergence rate between Africa and Europe.......During Late Cretaceous and Cenozoic times many Paleozoic and Mesozoic rifts and basin structures in the interior of the European continent underwent several phases of inversion. The main phases occurred during the Late Cretaceous and Middle Paleocene, and have been explained by pulses...... Paleocene phase was characterized by domal uplift of a wider area with only mild fault movements, and formation of more distal and shallow marginal troughs. A simple flexural model explains how domal, secondary inversion follows inevitably from primary, convergence related inversion upon relaxation...

  20. Wide-Range Probing of Dzyaloshinskii-Moriya Interaction

    Science.gov (United States)

    Kim, Duck-Ho; Yoo, Sang-Cheol; Kim, Dae-Yun; Min, Byoung-Chul; Choe, Sug-Bong

    2017-03-01

    The Dzyaloshinskii-Moriya interaction (DMI) in magnetic objects is of enormous interest, because it generates built-in chirality of magnetic domain walls (DWs) and topologically protected skyrmions, leading to efficient motion driven by spin-orbit torques. Because of its importance for both potential applications and fundamental research, many experimental efforts have been devoted to DMI investigation. However, current experimental probing techniques cover only limited ranges of the DMI strength and have specific sample requirements. Thus, there are no versatile methods to quantify DMI over a wide range of values. Here, we present such an experimental scheme, which is based on the angular dependence of asymmetric DW motion. This method can be used to determine values of DMI much larger than the maximum strength of the external magnetic field strength, which demonstrates that various DMI strengths can be quantified with a single measurement setup. This scheme may thus prove essential to DMI-related emerging fields in nanotechnology.

  1. Lake-wide distribution of Dreissena in Lake Michigan, 1999

    Science.gov (United States)

    Fleischer, Guy W.; DeSorcie, Timothy J.; Holuszko, Jeffrey D.

    2001-01-01

    The Great Lakes Science Center has conducted lake-wide bottom trawl surveys of the fish community in Lake Michigan each fall since 1973. These systematic surveys are performed at depths of 9 to 110 m at each of seven index sites around Lake Michigan. Zebra mussel (Dreissena polymorpha) populations have expanded to all survey locations and at a level to sufficiently contribute to the bottom trawl catches. The quagga (Dreissena bugensis), recently reported in Lake Michigan, was likely in the catches though not recognized. Dreissena spp. biomass ranged from about 0.6 to 15 kg/ha at the various sites in 1999. Dreissenid mussels were found at depths of 9 to 82 m, with their peak biomass at 27 to 46 m. The colonization of these exotic mussels has ecological implications as well as potential ramifications on the ability to sample fish consistently and effectively with bottom trawls in Lake Michigan.

  2. Wide bandwidth transimpedance amplifier for extremely high sensitivity continuous measurements.

    Science.gov (United States)

    Ferrari, Giorgio; Sampietro, Marco

    2007-09-01

    This article presents a wide bandwidth transimpedance amplifier based on the series of an integrator and a differentiator stage, having an additional feedback loop to discharge the standing current from the device under test (DUT) to ensure an unlimited measuring time opportunity when compared to switched discharge configurations while maintaining a large signal amplification over the full bandwidth. The amplifier shows a flat response from 0.6 Hz to 1.4 MHz, the capability to operate with leakage currents from the DUT as high as tens of nanoamperes, and rail-to-rail dynamic range for sinusoidal current signals independent of the DUT leakage current. Also available is a monitor output of the stationary current to track experimental slow drifts. The circuit is ideal for noise spectral and impedance measurements of nanodevices and biomolecules when in the presence of a physiological medium and in all cases where high sensitivity current measurements are requested such as in scanning probe microscopy systems.

  3. AID/APOBEC cytosine deaminase induces genome-wide kataegis

    Directory of Open Access Journals (Sweden)

    Lada Artem G

    2012-12-01

    Full Text Available Abstract Clusters of localized hypermutation in human breast cancer genomes, named “kataegis” (from the Greek for thunderstorm, are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have sequenced the genomes of yeast mutants induced in diploids by expression of the gene for PmCDA1, a hypermutagenic deaminase from sea lamprey. Analysis of the distribution of 5,138 induced mutations revealed localized clusters very similar to those found in tumors. Our data provide evidence that unleashed cytosine deaminase activity is an evolutionary conserved, prominent source of genome-wide kataegis events. Reviewers This article was reviewed by: Professor Sandor Pongor, Professor Shamil R. Sunyaev, and Dr Vladimir Kuznetsov.

  4. Development of a wide-range tritium-concentration detector

    Energy Technology Data Exchange (ETDEWEB)

    Jun, F.; Zhe, L.; Shicheng, L.; Jiangfeng, S.; Deli, L. [China Academy of Engineering Physics, Mianyang (China)

    2015-03-15

    According to the requirements of the tritium related systems of the TBM (Test Blanket Module) for monitoring the on-line tritium concentration, a wide-range tritium-concentration detector has been developed to measure the tritium concentration in the range of 10{sup 4} Bq/ml - 5*10{sup 8} Bq/ml. This detector is combined with a low-memory helium ionization chamber. The weak current signal collected in the ionization chamber is converted to the voltage signal by an I-V converter. The minimum weak current which the detector could be measured is 10{sup -14} A. The performance of the background current and the current response linearity of the prototype have been tested. The test result indicates that the linear response of the current signal of the prototype without connecting the ionization chamber is good. The linear correlation coefficient is R{sup 2} = 0.998.

  5. Development of a wide-range tritium-concentration detector

    International Nuclear Information System (INIS)

    Jun, F.; Zhe, L.; Shicheng, L.; Jiangfeng, S.; Deli, L.

    2015-01-01

    According to the requirements of the tritium related systems of the TBM (Test Blanket Module) for monitoring the on-line tritium concentration, a wide-range tritium-concentration detector has been developed to measure the tritium concentration in the range of 10 4 Bq/ml - 5*10 8 Bq/ml. This detector is combined with a low-memory helium ionization chamber. The weak current signal collected in the ionization chamber is converted to the voltage signal by an I-V converter. The minimum weak current which the detector could be measured is 10 -14 A. The performance of the background current and the current response linearity of the prototype have been tested. The test result indicates that the linear response of the current signal of the prototype without connecting the ionization chamber is good. The linear correlation coefficient is R 2 = 0.998

  6. World wide web implementation of the Langley technical report server

    Science.gov (United States)

    Nelson, Michael L.; Gottlich, Gretchen L.; Bianco, David J.

    1994-01-01

    On January 14, 1993, NASA Langley Research Center (LaRC) made approximately 130 formal, 'unclassified, unlimited' technical reports available via the anonymous FTP Langley Technical Report Server (LTRS). LaRC was the first organization to provide a significant number of aerospace technical reports for open electronic dissemination. LTRS has been successful in its first 18 months of operation, with over 11,000 reports distributed and has helped lay the foundation for electronic document distribution for NASA. The availability of World Wide Web (WWW) technology has revolutionized the Internet-based information community. This paper describes the transition of LTRS from a centralized FTP site to a distributed data model using the WWW, and suggests how the general model for LTRS can be applied to other similar systems.

  7. Judging nursing information on the world wide web.

    Science.gov (United States)

    Cader, Raffik

    2013-02-01

    The World Wide Web is increasingly becoming an important source of information for healthcare professionals. However, finding reliable information from unauthoritative Web sites to inform healthcare can pose a challenge to nurses. A study, using grounded theory, was undertaken in two phases to understand how qualified nurses judge the quality of Web nursing information. Data were collected using semistructured interviews and focus groups. An explanatory framework that emerged from the data showed that the judgment process involved the application of forms of knowing and modes of cognition to a range of evaluative tasks and depended on the nurses' critical skills, the time available, and the level of Web information cues. This article mainly focuses on the six evaluative tasks relating to assessing user-friendliness, outlook and authority of Web pages, and relationship to nursing practice; appraising the nature of evidence; and applying cross-checking strategies. The implications of these findings to nurse practitioners and publishers of nursing information are significant.

  8. Precise digital integration in wide time range: theory and realization

    International Nuclear Information System (INIS)

    Batrakov, A.M.; Pavlenko, A.V.

    2017-01-01

    The digital integration method based on using high-speed precision analog-to-digital converters (ADC) has become widely used over the recent years. The paper analyzes the limitations of this method that are caused by the signal properties, ADC sampling rate and noise spectral density of the ADC signal path. This analysis allowed creating digital integrators with accurate synchronization and achieving an integration error of less than 10 −5 in the time range from microseconds to tens of seconds. The structure of the integrator is described and its basic parameters are presented. The possibilities of different ADC chips in terms of their applicability to digital integrators are discussed. A comparison with other integrating devices is presented.

  9. The design of the wide field monitor for LOFT

    DEFF Research Database (Denmark)

    Brandt, Søren; Hernanz, M.; Alvarez, L.

    2014-01-01

    is designed to carry on-board two instruments with sensitivity in the 2-50 keV range: a 10 m 2 class Large Area Detector (LAD) with a monitor (WFM) making use of coded masks and providing an instantaneous coverage of more than 1/3 of the sky. The prime goal of the WFM...... will be to detect transient sources to be observed by the LAD. However, thanks to its unique combination of a wide field of view (FoV) and energy resolution (better than 500 eV), the WFM will be also an excellent monitoring instrument to study the long term variability of many classes of X-ray sources. The WFM...

  10. Ozone formation in pulsed SDBD in a wide pressure range

    Science.gov (United States)

    Starikovskiy, Andrey; Nudnova, Maryia; mipt Team

    2011-10-01

    Ozone concentration in surface anode-directed DBD for wide pressure range (150 - 1300 torr) was experimentally measured. Voltage and pressure effect were investigated. Reduced electric field was measured for anode-directed and cathode-directed SDBD. E/n values in cathode-directed SDBD is higher than in cathode-directed on 50 percent at atmospheric pressure. E/n value increase leads to decrease the rate of oxygen dissociation and Ozone formation at lower pressures. Radiating region thickness of sliding discharge was measured. Typical thickness of radiating zone is 0.4-1.0 mm within pressure range 220-740 torr. It was shown that high-voltage pulsed nanosecond discharge due to high E/n value produces less Ozone with compare to other discharges. Kinetic model was proposed to describe Ozone formation in the pulsed nanosecond SDBD.

  11. AUTOMATIC ADJUSTMENT OF WIDE-BASE GOOGLE STREET VIEW PANORAMAS

    Directory of Open Access Journals (Sweden)

    E. Boussias-Alexakis

    2016-06-01

    Full Text Available This paper focuses on the issue of sparse matching in cases of extremely wide-base panoramic images such as those acquired by Google Street View in narrow urban streets. In order to effectively use affine point operators for bundle adjustment, panoramas must be suitably rectified to simulate affinity. To this end, a custom piecewise planar projection (triangular prism projection is applied. On the assumption that the image baselines run parallel to the street façades, the estimated locations of the vanishing lines of the façade plane allow effectively removing projectivity and applying the ASIFT point operator on panorama pairs. Results from comparisons with multi-panorama adjustment, based on manually measured image points, and ground truth indicate that such an approach, if further elaborated, may well provide a realistic answer to the matching problem in the case of demanding panorama configurations.

  12. A comparison of multivariate genome-wide association methods

    DEFF Research Database (Denmark)

    Galesloot, Tessel E; Van Steen, Kristel; Kiemeney, Lambertus A L M

    2014-01-01

    Joint association analysis of multiple traits in a genome-wide association study (GWAS), i.e. a multivariate GWAS, offers several advantages over analyzing each trait in a separate GWAS. In this study we directly compared a number of multivariate GWAS methods using simulated data. We focused on six...... methods that are implemented in the software packages PLINK, SNPTEST, MultiPhen, BIMBAM, PCHAT and TATES, and also compared them to standard univariate GWAS, analysis of the first principal component of the traits, and meta-analysis of univariate results. We simulated data (N = 1000) for three...... for scenarios with an opposite sign of genetic and residual correlation. All multivariate analyses resulted in a higher power than univariate analyses, even when only one of the traits was associated with the QTL. Hence, use of multivariate GWAS methods can be recommended, even when genetic correlations between...

  13. A Genome-Wide Association Study Primer for Clinicians

    Directory of Open Access Journals (Sweden)

    Tzu-Hao Wang

    2009-06-01

    Full Text Available Genome-wide association studies (GWAS use high-throughput genotyping technology to relate hundreds of thousands of genetic markers (genotypes to clinical conditions and measurable traits (phenotypes. This review is intended to serve as an introduction to GWAS for clinicians, to allow them to better appreciate the value and limitations of GWAS for genotype-disease association studies. The input of clinicians is vital for GWAS, since disease heterogeneity is frequently a confounding factor that can only really be solved by clinicians. For diseases that are difficult to diagnose, clinicians should ensure that the cases do indeed have the disease; for common diseases, clinicians should ensure that the controls are truly disease-free.

  14. Control and test software for IRAM WideX correlator

    International Nuclear Information System (INIS)

    Blanchet, S.; Broguiere, D.; Chavatte, P.; Morel, F.; Perrigouard, A.; Torres, M.

    2012-01-01

    IRAM is an international research institute for radio astronomy. It has designed a new correlator called WideX for the Plateau de Bure interferometer (an array of six 15-meter telescopes) in the French Alps. The device started its official service in February 2010. This correlator must be driven in real-time at 32 Hz for sending parameters and for data acquisition. With 3.67 million channels, distributed over 1792 dedicated chips, that produce a 1.87 Gbits/sec data output rate, the data acquisition and processing and also the automatic hardware-failure detection are big challenges for the software. This article presents the software that has been developed to drive and test the correlator. In particular it presents an innovative usage of a high speed optical link, initially developed for the CERN ALICE experiment, associated with real-time Linux (RTAI) to achieve our goals. (authors)

  15. Dynamics of Mass Transfer in Wide Symbiotic Systems

    Science.gov (United States)

    de Val-Borro, Miguel; Karovska, M.; Sasselov, D.

    2010-01-01

    We investigate the formation of accretion disks around the secondary in detached systems consisting of an Asymptotic Giant Branch (AGB) star and a compact accreting companion as a function of mass loss rate and orbital parameters. In particular, we study winds from late-type stars that are gravitationally focused by a companion in a wide binary system using hydrodynamical simulations. For a typical slow and massive wind from an evolved star there is a stream flow between the stars with accretion rates of a few percent of the mass loss from the primary. Mass transfer through a focused wind is an important mechanism for a broad range of interacting binary systems and can explain the formation of Barium stars and other chemically peculiar stars.

  16. Wide angle view of MOCR activity during STS-3 mission

    Science.gov (United States)

    1982-01-01

    Wide angle view of Mission Operation Control Room (MOCR) activity during Day 2 of STS-3 mission. This view shows many of th consoles, tracking map, and Eidophor-controlled data screens. Flight controllers in the foreground are (l.r.) R. John Rector and Chares L. Dumie. They are seated at the EECOM console. The 'thermodillo' contraption, used by flight controllers to indicate the Shuttle's position in relation to the sun for various tests, can be seen at right (28732); closeup view of the 'thermodillo'. The position of the armadillo's tail indicates position of the orbiter in relation to sun (28733); Mission Specialist/Astronaut Sally K. Ride, STS-3 orbit team spacecraft communicator (CAPCOM), talks to flight director during mission control center activity. Mission Specialist/Astronaut George D. Nelson, backup orbit team CAPCOM, watches the monitor at his console (28734).

  17. Wide angle spectrometers for intermadiate energy electron accelerators

    International Nuclear Information System (INIS)

    Leconte, P.

    1982-10-01

    It is shown that improvements of the detector acceptances (in solid angle and momentum bite) is as important as increased duty cycle for coincidence experiments. To have a maximum efficiency and thus to reduce the cost of experiments, it is imperative to develop maximum solid angle systems. This implies an axial symmetry with respect to the incoming beam. At Saclay, we have investigated some of the properties of specific detectors covering up to 90% of 4π steradians for a high energy, 100% duty cycle electron accelerator. The techniques of wide angle spectrometers have already been explored on a large scale in high energy physics. However, in the case of charged particles, such detectors, compared to classical iron dipole spectrometers, present a smaller resolving power and a rather low background rejection. The choice of which of these two solutions is to be used depends on the conditions of the specific experiment

  18. WAMDII: The Wide Angle Michelson Doppler Imaging Interferometer

    Science.gov (United States)

    1992-01-01

    As part of an effort to learn more about the upper atmosphere and how it is linked to the weather experienced each day, NASA and NRCC are jointly sponsoring the Wide Angle Michelson Doppler Imaging Interferometer (WAMDII) Mission. WAMDII will measure atmospheric temperature and wind speed in the upper atmosphere. In addition to providing data on the upper atmosphere, the wind speed and temperature readings WAMDII takes will also be highly useful in developing and updating computer simulated models of the upper atmosphere. These models are used in the design and testing of equipment and software for Shuttles, satellites, and reentry vehicles. In making its wind speed and temperature measurements, WAMDII examines the Earth's airglow, a faint photochemical luminescence caused by the influx of solar ultraviolet energy into the upper atmosphere. During periods of high solar flare activity, the amount of this UV energy entering the upper atmosphere increases, and this increase may effect airglow emissions.

  19. Method for integrating a train of fast, nanosecond wide pulses

    International Nuclear Information System (INIS)

    Rose, C.R.

    1987-01-01

    This paper describes a method used to integrate a train of fast, nanosecond wide pulses. The pulses come from current transformers in a RF LINAC beamline. Because they are ac signals and have no dc component, true mathematical integration would yield zero over the pulse train period or an equally erroneous value because of a dc baseline shift. The circuit used to integrate the pulse train first stretches the pulses to 35 ns FWHM. The signals are then fed into a high-speed, precision rectifier which restores a true dc baseline for the following stage - a fast, gated integrator. The rectifier is linear over 55dB in excess of 25 MHz, and the gated integrator is linear over a 60 dB range with input pulse widths as short as 16 ns. The assembled system is linear over 30 dB with a 6 MHz input signal

  20. Type 1 diabetes genome-wide association studies

    DEFF Research Database (Denmark)

    Pociot, Flemming

    2017-01-01

    Genetic studies have identified >60 loci associated with the risk of developing type 1 diabetes (T1D). The vast majority of these are identified by genome-wide association studies (GWAS) using large case-control cohorts of European ancestry. More than 80% of the heritability of T1D can be explained...... by GWAS data in this population group. However, with few exceptions, their individual contribution to T1D risk is low and understanding their function in disease biology remains a huge challenge. GWAS on its own does not inform us in detail on disease mechanisms, but the combination of GWAS data...... with other omics-data is beginning to advance our understanding of T1D etiology and pathogenesis. Current knowledge supports the notion that genetic variation in both pancreatic β cells and in immune cells is central in mediating T1D risk. Advances, perspectives and limitations of GWAS are discussed...

  1. Genome-wide patterns of nucleotide polymorphism in domesticated rice

    DEFF Research Database (Denmark)

    Caicedo, Ana L; Williamson, Scott H; Hernandez, Ryan D

    2007-01-01

    Domesticated Asian rice (Oryza sativa) is one of the oldest domesticated crop species in the world, having fed more people than any other plant in human history. We report the patterns of DNA sequence variation in rice and its wild ancestor, O. rufipogon, across 111 randomly chosen gene fragments......, and use these to infer the evolutionary dynamics that led to the origins of rice. There is a genome-wide excess of high-frequency derived single nucleotide polymorphisms (SNPs) in O. sativa varieties, a pattern that has not been reported for other crop species. We developed several alternative models...... to explain contemporary patterns of polymorphisms in rice, including a (i) selectively neutral population bottleneck model, (ii) bottleneck plus migration model, (iii) multiple selective sweeps model, and (iv) bottleneck plus selective sweeps model. We find that a simple bottleneck model, which has been...

  2. Lithuanian on-line periodicals on the World Wide Web

    Directory of Open Access Journals (Sweden)

    Lina Sarlauskiene

    2001-01-01

    Full Text Available Deals with Lithuanian full-text electronic periodicals distributed through the World Wide Web. An electronic periodical is usually defined as a regular publication on some particular topic distributed in digital form, chiefly through the Web, but also by electronic mail or digital disk. The author has surveyed 106 publications. Thirty-four are distributed only on the Web, and 72 have printed versions. The number of analysed publications is not very big, but four years of electronic publishing and the variety of periodicals enables us to establish the causes of this phenomenon, the main features of development, and some perspectives. Electronic periodicals were analysed according to their type, purpose, contents, publisher, regularity, language, starting date and place of publication, and other features.

  3. Modelling of monovacancy diffusion in W over wide temperature range

    International Nuclear Information System (INIS)

    Bukonte, L.; Ahlgren, T.; Heinola, K.

    2014-01-01

    The diffusion of monovacancies in tungsten is studied computationally over a wide temperature range from 1300 K until the melting point of the material. Our modelling is based on Molecular Dynamics technique and Density Functional Theory. The monovacancy migration barriers are calculated using nudged elastic band method for nearest and next-nearest neighbour monovacancy jumps. The diffusion pre-exponential factor for monovacancy diffusion is found to be two to three orders of magnitude higher than commonly used in computational studies, resulting in attempt frequency of the order 10 15 Hz. Multiple nearest neighbour jumps of monovacancy are found to play an important role in the contribution to the total diffusion coefficient, especially at temperatures above 2/3 of T m , resulting in an upward curvature of the Arrhenius diagram. The probabilities for different nearest neighbour jumps for monovacancy in W are calculated at different temperatures

  4. Wide spectrum antireflective coating for laser fusion systems. Final report

    International Nuclear Information System (INIS)

    Yoldas, B.E; Partlow, D.P.; Smith, H.D.; Mattox, D.M.

    1984-01-01

    A method of depositing a laser damage resistant, wide-spectrum antireflective coating on fused silica has been developed. This work was sponsored under a subcontract with the University of California, with technical direction from the Lawrence Livermore National Laboratory. The coating is applied from a specific silanol polymer solution and converted to a porous SiO 2 film. The pore size of the film is first reduced by a heat treatment to prevent uv scattering. Then gradation of the pore volume is achieved by a mild etching to a sufficient depth to prevent a smoother index transition from air to the substrate glass. The resulting antireflectivity covers the entire transmission range of silica and may be extended to a wavelength as short as 250 nm. Laser damage thresholds as high as 9 j/cm 2 have been demonstrated on processed samples

  5. Wide-field surveys from the SNAP mission

    International Nuclear Information System (INIS)

    2002-01-01

    The Supernova/Acceleration Probe (SNAP) is a proposed space-borne observatory that will survey the sky with a wide-field optical/NIR imager. The images produced by SNAP will have an unprecedented combination of depth, solid-angle, angular resolution, and temporal sampling. Two 7.5 square-degree fields will be observed every four days over 16 months to a magnitude depth of AB = 27.7 in each of nine filters. Co-adding images over all epochs will give an AB = 30.3 per filter. A 300 square-degree field will be surveyed with no repeat visits to AB = 28 per filter. The nine filters span 3500-17000 (angstrom). Although the survey strategy is tailored for supernova and weak gravitational lensing observations, the resulting data supports a broad range of auxiliary science programs

  6. Simultaneous wide-range stopping power determination for several ions

    Energy Technology Data Exchange (ETDEWEB)

    Alanko, T. E-mail: tommi.alanko@phys.jyu.fi; Trzaska, W.H.; Lyapin, V.; Raeisaenen, J.; Tiourine, G.; Virtanen, A

    2002-05-01

    A new procedure to extract simultaneously continuous stopping power curves for several ions and several absorbers over a wide energy range and with statistical errors reduced to negligible level is presented. The method combines our novel time-of-flight based method with the capability of our K130 cyclotron and ECR ion-source to produce the so-called ion cocktails. The potential of the method is demonstrated with a 6.0 MeV/u cocktail consisting of {sup 16}O{sup 4+}, {sup 28}Si{sup 7+} and {sup 40}Ar{sup 10+} ions. The stopping power in polycarbonate in the energy range of 0.35-5 MeV/u has been determined with absolute uncertainty of less than 2.3% and with relative below 0.2%. The results are compared with literature data and with SRIM2000 parameterisation including cores and bonds corrections.

  7. Quantum conductance of carbon nanotubes in a wide energy range

    International Nuclear Information System (INIS)

    Zhang, Yong

    2015-01-01

    The differential conductance of armchair and zigzag carbon nanotubes (CNTs) in a wide energy range has been numerically calculated by using the tight-binding model and the Green’s function method. The effects of the contact coupling between CNTs and electrodes on conductance have been explored. The ballistic conductance is proportional to the band numbers and has a ladder-like feature. As the increase of the contact coupling, the conductance oscillations appear and they are robust against the coupling. More importantly, on the first step of the conductance ladder, the armchair CNTs have two quasi-periodic conductance oscillations, i.e. a rapid conductance oscillation superimposed on a slow fluctuation background; while the zigzag CNTs have only one conductance oscillation. But on the second conductance step, all CNTs have two quasi-periodic conductance oscillations. The physical origin of the conductance oscillations has been revealed

  8. Business Planning for a Campus-Wide Biobank.

    Science.gov (United States)

    Tarling, Tamsin E; Lasser, Frances; Carter, Candace; Matzke, Lise A M; Dhugga, Gurm; Arora, Nidhi; Dee, Simon; LeBlanc, Jodi; Babinsky, Sindy; O'Donoghue, Sheila; Cheah, Stefanie; Watson, Peter; Vercauteren, Suzanne M

    2017-02-01

    Biobanks are resources that facilitate research. Many biobanks exist around the world, but most tend to focus on a specific disease or research area. BC Children's Hospital and BC Women's Hospital are located on the same campus (Oak Street Campus) in Vancouver, BC, Canada. A campus-wide biobank has been established on the site of these two hospitals to collect specimens and annotated data from children or women seeking medical care at either of the hospitals. Such an initiative requires careful planning and consideration of many factors such as buy in and support of key stakeholders, governance, financial planning, and optimizing specimen collection. We developed a business plan to account for the many aspects associated with integrating the "BC Children's Hospital BioBank." This document describes the approach our business plan took for the implementation of our biobank and the progress, including deviations from the business plan. We also provide a perspective on the current status with a focus on sustainability.

  9. The effect of problems on supply chain wide efficiency

    Directory of Open Access Journals (Sweden)

    Micheline J. Naude

    2011-11-01

    This article reports on an exploratory empirical study to illustrate the effect of problems at one party in the supply chain on the whole supply chain. The study was done at automotive component manufacturers. To determine how problems at one place permeate through the whole supply chain, correlation testing was done between supply-side, internal operations, and distribution or customer-side problems. The study found that problems experienced at one place in the supply chain had a negative impact throughout the supply chain. Automotive supply chains should therefore be managed more as a system, taking into consideration the effect of decision making and actions at one part of the supply chain on other parts of the supply chain. There should be a supply chain wide co-operative effort to find solutions to inefficiencies at all places in the supply chain.

  10. Wide-band coherent receiver development for enhanced surveillance

    International Nuclear Information System (INIS)

    Simpson, M.L.; Richards, R.K.; Hutchinson, D.P.

    1998-03-01

    Oak Ridge National Laboratory (ORNL) has been developing advanced coherent IR heterodyne receivers for plasma diagnostics in fusion reactors for over 20 years. Recent progress in wide band IR detectors and high speed electronics has significantly enhanced the measurement capabilities of coherent receivers. In addition, developments in new HgCdTe and quantum well IR photodetector (QWIP) focal plane arrays are providing the possibility of both active and passive coherent imaging. In this paper the authors discuss the implications of these new enabling technologies to the IR remote sensing community for enhanced surveillance. Coherent receivers, as opposed to direct or thermal detection, provide multiple dimensions of information about a scene or target in a single detector system. Combinations of range, velocity, temperature, and chemical species information are all available from a coherent heterodyne receiver. They present laboratory data showing measured noise equivalent power (NEP) of new QWIP detectors with heterodyne bandwidths greater than 7 GHz. For absorption measurements, a wide band coherent receiver provides the capability of looking between CO 2 lines at off-resonance peaks and thus the measurement of lines normally inaccessible with conventional heterodyne or direct detection systems. Also described are differential absorption lidar (DIAL) and Doppler laboratory measurements using an 8 x 8 HgCdTe focal plane array demonstrating the snapshot capability of coherent receiver detector arrays for enhanced chemical plume and moving hardbody capture. Finally they discuss a variety of coherent receiver configurations that can suppress (or enhance) sensitivity of present active remote sensing systems to speckle, glint, and other measurement anomalies

  11. WorldWide Telescope in High School Astronomy Competitions

    Science.gov (United States)

    Constantin, Ana-Maria; Goodman, A. A.; Udomprasert, P. S.

    2014-01-01

    This project aims to improve astronomy education at the high school level, and to increase awareness in astronomy for pre-university students, on an international scale. In 2013, the WorldWide Telescope Ambassadors Program began a collaboration with the International Olympiad in Astronomy and Astrophysics (IOAA), which was held in the city of Volos, Greece in August 2013. Now at its VIIth edition, IOAA is the largest annual astronomy competition for high school students, and it consists of one team task and three individual ones - Theoretical, Data Analysis, and Observational. Each of the participating countries (35 in 2013, compared to 21 in 2007) is responsible for selecting up to five representative students for the International round. IOAA is meant to promote future collaborations between these students, and to encourage friendships inside a global scientific community. Ana-Maria Constantin, a current Harvard undergraduate student and a former medalist of IOAA, represented WorldWide Telescope Ambassadors in Greece by giving a talk on the advantages of using WWT as a tool for research and education. As a result, the President and the International Board of the Olympiad have expressed support for including WWT in the competition for future editions. WWTA is working with the Organizing Board for next year’s competition in Romania, to include WWT as a testing tool. This poster will summarize key points from the WWTA presentation in Greece, present ideas for WWT-based activities in future IOAA competitions, and outline plans for new collaborations from representatives of Sri Lanka, Poland, Bangladesh, and Colombia. Given the positive feedback we have received after the presentation in Greece, we are also considering future implementations of WWT in summer research camps for high school students, such as the Summer Science Program.

  12. Wide-Temperature Electrolytes for Lithium-Ion Batteries.

    Science.gov (United States)

    Li, Qiuyan; Jiao, Shuhong; Luo, Langli; Ding, Michael S; Zheng, Jianming; Cartmell, Samuel S; Wang, Chong-Min; Xu, Kang; Zhang, Ji-Guang; Xu, Wu

    2017-06-07

    Formulating electrolytes with solvents of low freezing points and high dielectric constants is a direct approach to extend the service-temperature range of lithium (Li)-ion batteries (LIBs). In this study, we report such wide-temperature electrolyte formulations by optimizing the ethylene carbonate (EC) content in the ternary solvent system of EC, propylene carbonate (PC), and ethyl methyl carbonate (EMC) with LiPF 6 salt and CsPF 6 additive. An extended service-temperature range from -40 to 60 °C was obtained in LIBs with lithium nickel cobalt aluminum oxide (LiNi 0.80 Co 0.15 Al 0.05 O 2 , NCA) as cathode and graphite as anode. The discharge capacities at low temperatures and the cycle life at room temperature and elevated temperatures were systematically investigated together with the ionic conductivity and phase-transition behaviors. The most promising electrolyte formulation was identified as 1.0 M LiPF 6 in EC-PC-EMC (1:1:8 by wt) with 0.05 M CsPF 6 , which was demonstrated in both coin cells of graphite∥NCA and 1 Ah pouch cells of graphite∥LiNi 1/3 Mn 1/3 Co 1/3 O 2 . This optimized electrolyte enables excellent wide-temperature performances, as evidenced by the high capacity retention (68%) at -40 °C and C/5 rate, significantly higher than that (20%) of the conventional LIB electrolyte, and the nearly identical stable cycle life as the conventional LIB electrolyte at room temperature and elevated temperatures up to 60 °C.

  13. An optimal design for millimeter-wide facture plugging zone

    Directory of Open Access Journals (Sweden)

    Yili Kang

    2015-01-01

    Full Text Available Lost circulation control in millimeter-wide fractures has been a challenge in well drilling all the time. Low pressure-bearing capacity of a plugging zone will result in excessive consumption of lost circulation materials (LCMs and extra down time. In this study, laboratory experiments were conducted on the plugging of millimeter-wide fractures to evaluate the plugging effects of different types of LCM including rigid granules, elastic particles and fiber. Maximum plugging pressure, total loss volume before sealing and plugging time were taken as the evaluation index of the LCM plugging effect. According to the experimental results, the synergistic plugging mechanisms of different LCM combinations were also analyzed. Experimental results showed that the total loss volume of the plugging zone formed by rigid and elastic particle combination was generally greater than 400 mL, and the maximum plugging pressure of the plugging zone formed by elastic particle and fiber combination was generally less than 6 MPa. In contrast, the plugging zone formed by the combination of the three types of LCMs has the maximum plugging pressure of up to 13 MPa and total loss volume before sealing of 75 mL. In the synergistic plugging process, rigid granules form a frame with high pressure-bearing capacity in the narrower parts of the fractures; elastic particles generate elastic force through elastic deformation to increase the friction between a fracture and a plugging zone to make the plugging zone more stable; fibers filling in the pore space between the particles increase the tightness and integrity of the plugging zone. The experimental results can provide guidance for the optimal design of LCMs used in the field.

  14. Genome-wide expression profiling of complex regional pain syndrome.

    Directory of Open Access Journals (Sweden)

    Eun-Heui Jin

    Full Text Available Complex regional pain syndrome (CRPS is a chronic, progressive, and devastating pain syndrome characterized by spontaneous pain, hyperalgesia, allodynia, altered skin temperature, and motor dysfunction. Although previous gene expression profiling studies have been conducted in animal pain models, there genome-wide expression profiling in the whole blood of CRPS patients has not been reported yet. Here, we successfully identified certain pain-related genes through genome-wide expression profiling in the blood from CRPS patients. We found that 80 genes were differentially expressed between 4 CRPS patients (2 CRPS I and 2 CRPS II and 5 controls (cut-off value: 1.5-fold change and p<0.05. Most of those genes were associated with signal transduction, developmental processes, cell structure and motility, and immunity and defense. The expression levels of major histocompatibility complex class I A subtype (HLA-A29.1, matrix metalloproteinase 9 (MMP9, alanine aminopeptidase N (ANPEP, l-histidine decarboxylase (HDC, granulocyte colony-stimulating factor 3 receptor (G-CSF3R, and signal transducer and activator of transcription 3 (STAT3 genes selected from the microarray were confirmed in 24 CRPS patients and 18 controls by quantitative reverse transcription-polymerase chain reaction (qRT-PCR. We focused on the MMP9 gene that, by qRT-PCR, showed a statistically significant difference in expression in CRPS patients compared to controls with the highest relative fold change (4.0±1.23 times and p = 1.4×10(-4. The up-regulation of MMP9 gene in the blood may be related to the pain progression in CRPS patients. Our findings, which offer a valuable contribution to the understanding of the differential gene expression in CRPS may help in the understanding of the pathophysiology of CRPS pain progression.

  15. A genome-wide association study of attempted suicide

    Science.gov (United States)

    Willour, Virginia L.; Seifuddin, Fayaz; Mahon, Pamela B.; Jancic, Dubravka; Pirooznia, Mehdi; Steele, Jo; Schweizer, Barbara; Goes, Fernando S.; Mondimore, Francis M.; MacKinnon, Dean F.; Perlis, Roy H.; Lee, Phil Hyoun; Huang, Jie; Kelsoe, John R.; Shilling, Paul D.; Rietschel, Marcella; Nöthen, Markus; Cichon, Sven; Gurling, Hugh; Purcell, Shaun; Smoller, Jordan W.; Craddock, Nicholas; DePaulo, J. Raymond; Schulze, Thomas G.; McMahon, Francis J.; Zandi, Peter P.; Potash, James B.

    2011-01-01

    The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. While attempted suicide linkage regions have been identified on 2p11–12 and 6q25–26, there are likely many more such loci, the discovery of which will require a much higher resolution approach, such as the genome-wide association study (GWAS). With this in mind, we conducted an attempted suicide GWAS that compared the single nucleotide polymorphism (SNP) genotypes of 1,201 bipolar (BP) subjects with a history of suicide attempts to the genotypes of 1,497 BP subjects without a history of suicide attempts. 2,507 SNPs with evidence for association at p<0.001 were identified. These associated SNPs were subsequently tested for association in a large and independent BP sample set. None of these SNPs were significantly associated in the replication sample after correcting for multiple testing, but the combined analysis of the two sample sets produced an association signal on 2p25 (rs300774) at the threshold of genome-wide significance (p= 5.07 × 10−8). The associated SNPs on 2p25 fall in a large linkage disequilibrium block containing the ACP1 gene, a gene whose expression is significantly elevated in BP subjects who have completed suicide. Furthermore, the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. Larger GWAS sample sets will be required to confirm the signal on 2p25 and to identify additional genetic risk factors increasing susceptibility for attempted suicide. PMID:21423239

  16. Testing Modified Gravity Theories via Wide Binaries and GAIA

    Science.gov (United States)

    Pittordis, Charalambos; Sutherland, Will

    2018-06-01

    The standard ΛCDM model based on General Relativity (GR) including cold dark matter (CDM) is very successful at fitting cosmological observations, but recent non-detections of candidate dark matter (DM) particles mean that various modified-gravity theories remain of significant interest. The latter generally involve modifications to GR below a critical acceleration scale ˜10-10 m s-2. Wide-binary (WB) star systems with separations ≳ 5 kAU provide an interesting test for modified gravity, due to being in or near the low-acceleration regime and presumably containing negligible DM. Here, we explore the prospects for new observations pending from the GAIA spacecraft to provide tests of GR against MOND or TeVes-like theories in a regime only partially explored to date. In particular, we find that a histogram of (3D) binary relative velocities, relative to equilibrium circular velocity predicted from the (2D) projected separation predicts a rather sharp feature in this distribution for standard gravity, with an 80th (90th) percentile value close to 1.025 (1.14) with rather weak dependence on the eccentricity distribution. However, MOND/TeVeS theories produce a shifted distribution, with a significant increase in these upper percentiles. In MOND-like theories without an external field effect, there are large shifts of order unity. With the external field effect included, the shifts are considerably reduced to ˜0.04 - 0.08, but are still potentially detectable statistically given reasonably large samples and good control of contaminants. In principle, followup of GAIA-selected wide binaries with ground-based radial velocities accurate to ≲ 0.03 { km s^{-1}} should be able to produce an interesting new constraint on modified-gravity theories.

  17. Tema y narración en Eyes Wide Shut

    Directory of Open Access Journals (Sweden)

    Cánovas Méndez, Marcos

    2011-04-01

    Full Text Available The narrative and thematic complexity of the film Eyes Wide Shut, directed by Stanley Kubrick, requires an interpretation that takes into account the interrelation between the subject of the film, the plot and the novella on which it is based, Traumnovelle (Dream Story, by Arthur Schnitzler. The plot revolves around a single theme, the sexual impulses of a couple –and the dreams and fantasies related to them– in a story where sexual episodes follow one another throughout. The scenes portrayed are a projection of the unconscious mind (in dreams, in fantasies, and also in far-fetched reality, acquiring increasing intensity till the bathos of everyday life returns at the end of the film.A partir de la complejidad argumental y temática de la película Eyes Wide Shut, dirigida por Stanley Kubrick, se presenta una propuesta interpretativa que analiza la relación entre el tema de la película, la trama narrativa y la novela en que se basa, Traumnovelle (Relato soñado, de Arthur Schnitzler. La estructura argumental se sostiene en un elemento temático específico, los impulsos sexuales de una pareja –y los sueños y las fantasías vinculados–, en una trama en la que se suceden episodios que representan estos impulsos. Las escenas proyectan las tendencias del inconsciente de los personajes (en sueños, en fantasías y también en situaciones dudosamente reales de forma cada vez más intensa, hasta llegar al anticlímax de cotidianidad con que concluye la película.

  18. Wide-area monitoring to detect undeclared nuclear facilities

    International Nuclear Information System (INIS)

    Wogman, N.

    1994-09-01

    The International Atomic Energy Agency (IAEA) is committed to strengthening and streamlining the overall effectiveness of the IAEA safeguards system. The IAEA is investigating the use of environmental monitoring techniques to strengthen its capability to detect undeclared nuclear activities. The IAEA's Program 93+2 Initiative has been established to develop, test, and assess strengthening techniques and measures. Some of the techniques have been validated and are being implemented during routine safeguards inspections. The effectiveness of other techniques is being studied as a part of extensive field trials conducted at nuclear facilities of various Member States during 1993 and 1994. Proposals based on the results of these investigations and recommendations for new safeguards activities are expected to be presented to the March 1995 Board of Governors Meeting. The techniques in use or under study during IAEA field trials address various types of environmental monitoring applications as outlined under Program 93+2's Task 3, Environmental Monitoring Techniques for Safeguards Applications, namely, the use of short-range monitoring during inspections and visits to investigate sites of possible undeclared activities. With the exception of wide-area water sampling in Iraq, the use of long-range monitoring, in the absence of any indication of undeclared nuclear activities, remains largely unexamined by the IAEA. The efficacy of long-range monitoring depends on the availability of mobile signature isotopes or compounds and on the ability to distinguish the nuclear signatures from background signals and attributing them to a source. The scope of this paper is to provide technical information to the International Atomic Energy Agency (IAEA) on possible wide-area survey techniques for the detection of undeclared nuclear activities. The primary focus is the detection of effluents from reprocessing activities

  19. Status of computed tomography dosimetry for wide cone beam scanners

    International Nuclear Information System (INIS)

    2011-01-01

    International standardization in dosimetry is essential for the successful exploitation of radiation technology. To provide such standardization in diagnostic radiology, the IAEA published Code of Practice entitled Dosimetry in Diagnostic Radiology: An International Code of Practice (IAEA Technical Reports Series No. 457; 2007), which recommends procedures for calibration and dosimetric measurement both in standards dosimetry laboratories, especially Secondary Standards Dosimetry Laboratories (SSDLs), and in clinical centres for radiology, as found in most hospitals. These standards address the main dosimetric methodologies needed in clinical diagnostic radiology, with the calibration of associated dosimetric equipment, including the measurement methodologies for computed tomography (CT). For some time now there has been a growing awareness that radiation dose originating from medical diagnostic procedures in radiology, is contributing an increasing proportion to the total population dose, with a large component coming from CT examinations. This is accompanied by rapid developments in CT technology, including the use of increasingly wide X ray scanning beams, which are presenting problems in dosimetry that currently cannot be adequately addressed by existing standards. This situation has received attention from a number of professional bodies, and institutions have proposed and are investigating new and adapted dosimetric models in order to find robust solutions to these problems that are critically affecting clinical application of CT dosimetry. In view of these concerns, and as a response to a recommendation from a coordinated research project that reviewed the implementation of IAEA Technical Reports Series No. 457, a meeting was held to review current dosimetric methodologies and to determine if a practical solution for dosimetry for wide X ray beam CT scanners was currently available. The meeting rapidly formed the view that there was an interim solution that

  20. Medical mentoring via the evolving world wide web.

    Science.gov (United States)

    Jaffer, Usman; Vaughan-Huxley, Eyston; Standfield, Nigel; John, Nigel W

    2013-01-01

    Mentoring, for physicians and surgeons in training, is advocated as an essential adjunct in work-based learning, providing support in career and non-career related issues. The World Wide Web (WWW) has evolved, as a technology, to become more interactive and person centric, tailoring itself to the individual needs of the user. This changing technology may open new avenues to foster mentoring in medicine. DESIGN, SYSTEMATIC REVIEW, MAIN OUTCOME MEASURES: A search of the MEDLINE database from 1950 to 2012 using the PubMed interface, combined with manual cross-referencing was performed using the following strategy: ("mentors"[MeSH Terms] OR "mentors"[All Fields] OR "mentor"[All Fields]) AND ("internet"[MeSH Terms] OR "internet"[All Fields]) AND ("medicine"[MeSH Terms] OR "medicine"[All Fields]) AND ("humans"[MeSH Terms] AND English[lang]). Abstracts were screened for relevance (UJ) to the topic; eligibility for inclusion was simply on screening for relevance to online mentoring and web-based technologies. Forty-five papers were found, of which 16 were relevant. All studies were observational in nature. To date, all medical mentoring applications utilizing the World Wide Web have enjoyed some success limited by Web 1.0 and 2.0 technologies. With the evolution of the WWW through 1.0, 2.0 and 3.0 generations, the potential for meaningful tele- and distance mentoring has greatly improved. Some engagement has been made with these technological advancements, however further work is required to fully realize the potential of these technologies. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  1. Genome-wide association studies in asthma: progress and pitfalls

    Directory of Open Access Journals (Sweden)

    March ME

    2015-01-01

    Full Text Available Michael E March,1 Patrick MA Sleiman,1,2 Hakon Hakonarson1,2 1Center for Applied Genomics, Children's Hospital of Philadelphia Research Institute, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Genetic studies of asthma have revealed that there is considerable heritability to the phenotype. An extensive history of candidate-gene studies has identified a long list of genes associated with immune function that are potentially involved in asthma pathogenesis. However, many of the results of candidate-gene studies have failed to be replicated, leaving in question the true impact of the implicated biological pathways on asthma. With the advent of genome-wide association studies, geneticists are able to examine the association of hundreds of thousands of genetic markers with a phenotype, allowing the hypothesis-free identification of variants associated with disease. Many such studies examining asthma or related phenotypes have been published, and several themes have begun to emerge regarding the biological pathways underpinning asthma. The results of many genome-wide association studies have currently not been replicated, and the large sample sizes required for this experimental strategy invoke difficulties with sample stratification and phenotypic heterogeneity. Recently, large collaborative groups of researchers have formed consortia focused on asthma, with the goals of sharing material and data and standardizing diagnosis and experimental methods. Additionally, research has begun to focus on genetic variants that affect the response to asthma medications and on the biology that generates the heterogeneity in the asthma phenotype. As this work progresses, it will move asthma patients closer to more specific, personalized medicine. Keywords: asthma, genetics, GWAS, pharmacogenetics, biomarkers

  2. Identification of neural outgrowth genes using genome-wide RNAi.

    Directory of Open Access Journals (Sweden)

    Katharine J Sepp

    2008-07-01

    Full Text Available While genetic screens have identified many genes essential for neurite outgrowth, they have been limited in their ability to identify neural genes that also have earlier critical roles in the gastrula, or neural genes for which maternally contributed RNA compensates for gene mutations in the zygote. To address this, we developed methods to screen the Drosophila genome using RNA-interference (RNAi on primary neural cells and present the results of the first full-genome RNAi screen in neurons. We used live-cell imaging and quantitative image analysis to characterize the morphological phenotypes of fluorescently labelled primary neurons and glia in response to RNAi-mediated gene knockdown. From the full genome screen, we focused our analysis on 104 evolutionarily conserved genes that when downregulated by RNAi, have morphological defects such as reduced axon extension, excessive branching, loss of fasciculation, and blebbing. To assist in the phenotypic analysis of the large data sets, we generated image analysis algorithms that could assess the statistical significance of the mutant phenotypes. The algorithms were essential for the analysis of the thousands of images generated by the screening process and will become a valuable tool for future genome-wide screens in primary neurons. Our analysis revealed unexpected, essential roles in neurite outgrowth for genes representing a wide range of functional categories including signalling molecules, enzymes, channels, receptors, and cytoskeletal proteins. We also found that genes known to be involved in protein and vesicle trafficking showed similar RNAi phenotypes. We confirmed phenotypes of the protein trafficking genes Sec61alpha and Ran GTPase using Drosophila embryo and mouse embryonic cerebral cortical neurons, respectively. Collectively, our results showed that RNAi phenotypes in primary neural culture can parallel in vivo phenotypes, and the screening technique can be used to identify many new

  3. Trade issues and area-wide pest management

    International Nuclear Information System (INIS)

    Griffin, Robert L.

    2000-01-01

    Food security and economic security are unarguably desirable objectives for all nations - indeed for the world. Equally important is the sustainability of designs that achieve these objectives without disadvantaging others or damaging the environment. Considering area-wide pest management in the context of these interrelated global policy forces is essential to fully understand its role in both the protection of plant resources and in facilitation of trade. The case for food security begins with the realisation that there are currently about 800 million people in the world who are suffering from malnutrition due to lack of food. The World Food Summit, convened in November 1996, urgently called for coordinated world-wide action to ensure 'food for all'. A key strategy for realising this goal is reducing losses due to plant pests. In this light, area-wide pest management can be viewed as a valuable addition to the toolbox of pest management strategies. It can also be one of the most sustainable and cost-effective options to consider for pest management. However, just as the problem of world hunger is not solved by a single farmer, area-wide pest management cannot be successful at the individual level. It requires commitment and cooperation to make it feasible - the same type of commitment and cooperation that was expressed at the World Food Summit. Where economic security is concerned, one need not look far to see a world of growing economic integration and widening circles of development. As the World Trade Organisation celebrates the 50th anniversary of the rules-based trading system which began with the GATT after World War II, it is clear that globalisation and the liberalisation of trade have become permanent fixtures in international policy formulation and are integral to the economic security of all nations. Now, more than ever before, the world's prosperity rests on maintaining an open international economy based on commonly agreed rules. The significance of

  4. Test Review for Preschool-Wide Evaluation Tool (PreSET) Manual: Assessing Universal Program-Wide Positive Behavior Support in Early Childhood

    Science.gov (United States)

    Rodriguez, Billie Jo

    2013-01-01

    The Preschool-Wide Evaluation Tool (PreSET; Steed & Pomerleau, 2012) is published by Paul H. Brookes Publishing Company in Baltimore, MD. The PreSET purports to measure universal and program-wide features of early childhood programs' implementation fidelity of program-wide positive behavior intervention and support (PW-PBIS) and is,…

  5. A Reconfigurable Series Resonant DC-DC Converter for Wide-Input and Wide-Output Voltages

    DEFF Research Database (Denmark)

    Shen, Yanfeng; Wang, Huai; Qin, Zian

    2017-01-01

    This paper proposes a dual-bridge based LC series resonant dc-dc converter. The input inverter unit incorporates two bridge structures, i.e., a full-bridge inverter and a half-bridge inverter. For the output rectifier, it can be a full-bridge rectifier or an asymmetric half-bridge rectifier....... Different from the conventional resonant converter, a fixed-frequency PWM control is employed which makes the optimization of magnetic components easier. The primary-side switches can achieve ZVS and the secondary-side diodes turn off with ZCS. In addition, the root-mean-square (RMS) values...... of the transformer currents do not significantly vary with respect to the voltage variation. Therefore, this converter can maintain high efficiency over a wide voltage range. The topology and operating principle are firstly described. Then the dc voltage gain and the RMS current characteristics are detailed. Finally...

  6. Development of autonomous magnetometer rotorcraft for wide area assessment

    Energy Technology Data Exchange (ETDEWEB)

    Roelof Versteeg; Matt Anderson; Les Beard; Eric Corban; Darryl Curley; Jeff Gamey; Ross Johnson; Dwight Junkin; Mark McKay; Jared Salzmann; Mikhail Tchernychev; Suraj Unnikrishnan; Scott Vinson

    2010-04-01

    Large areas across the United States are potentially contaminated with UXO, with some ranges encompassing tens to hundreds of thousands of acres. Technologies are needed which will allow for cost effective wide area scanning with 1) near 100 % coverage and 2) near 100 % detection of subsurface ordnance or features indicative of subsurface ordnance. The current approach to wide area assessment is a multi-level one, in which medium - altitude fixed wing optical imaging is used for an initial site assessment. This assessment is followed with low altitude manned helicopter based magnetometry. Subsequent to this wide area assessment targeted surface investigations are performed using either towed geophysical sensor arrays or man portable sensors. In order to be an effective tool for small UXO detection, the sensing altitude for magnetic site investigations needs to be on the order of 1 – 3 meters. These altitude requirements mean that manned helicopter surveys will generally only be feasible in large, open and relatively flat terrains. While such surveys are effective in mapping large areas relatively fast there are substantial mobilization/demobilization, staffing and equipment costs associated with these surveys (resulting in costs of approximately $100-$150/acre). In addition, due to the low altitude there are substantial risks to pilots and equipment. Surface towed arrays provide high resolution maps but have other limitations, e.g. in their ability to navigate rough terrain effectively. There is thus a need for other systems which can be used for effective data collection. An UAV (Unmanned Aerial Vehicle) magnetometer platform is an obvious alternative. The motivation behind such a system is that it reduces risk to operators, is lower in initial and Operational and Maintenance (O&M) costs (and can thus potentially be applied to smaller sites) and has the potential of being more effective in terms of detection and possibly characterization (through the use of

  7. Information about liver transplantation on the World Wide Web.

    Science.gov (United States)

    Hanif, F; Sivaprakasam, R; Butler, A; Huguet, E; Pettigrew, G J; Michael, E D A; Praseedom, R K; Jamieson, N V; Bradley, J A; Gibbs, P

    2006-09-01

    Orthotopic liver transplant (OLTx) has evolved to a successful surgical management for end-stage liver diseases. Awareness and information about OLTx is an important tool in assisting OLTx recipients and people supporting them, including non-transplant clinicians. The study aimed to investigate the nature and quality of liver transplant-related patient information on the World Wide Web. Four common search engines were used to explore the Internet by using the key words 'Liver transplant'. The URL (unique resource locator) of the top 50 returns was chosen as it was judged unlikely that the average user would search beyond the first 50 sites returned by a given search. Each Web site was assessed on the following categories: origin, language, accessibility and extent of the information. A weighted Information Score (IS) was created to assess the quality of clinical and educational value of each Web site and was scored independently by three transplant clinicians. The Internet search performed with the aid of the four search engines yielded a total of 2,255,244 Web sites. Of the 200 possible sites, only 58 Web sites were assessed because of repetition of the same Web sites and non-accessible links. The overall median weighted IS was 22 (IQR 1 - 42). Of the 58 Web sites analysed, 45 (77%) belonged to USA, six (10%) were European, and seven (12%) were from the rest of the world. The median weighted IS of publications originating from Europe and USA was 40 (IQR = 22 - 60) and 23 (IQR = 6 - 38), respectively. Although European Web sites produced a higher weighted IS [40 (IQR = 22 - 60)] as compared with the USA publications [23 (IQR = 6 - 38)], this was not statistically significant (p = 0.07). Web sites belonging to the academic institutions and the professional organizations scored significantly higher with a median weighted IS of 28 (IQR = 16 - 44) and 24(12 - 35), respectively, as compared with the commercial Web sites (median = 6 with IQR of 0 - 14, p = .001). There

  8. High Precision Sunphotometer using Wide Dynamic Range (WDR) Camera Tracking

    Science.gov (United States)

    Liss, J.; Dunagan, S. E.; Johnson, R. R.; Chang, C. S.; LeBlanc, S. E.; Shinozuka, Y.; Redemann, J.; Flynn, C. J.; Segal-Rosenhaimer, M.; Pistone, K.; Kacenelenbogen, M. S.; Fahey, L.

    2016-12-01

    High Precision Sunphotometer using Wide Dynamic Range (WDR) Camera TrackingThe NASA Ames Sun-photometer-Satellite Group, DOE, PNNL Atmospheric Sciences and Global Change Division, and NASA Goddard's AERONET (AErosol RObotic NETwork) team recently collaborated on the development of a new airborne sunphotometry instrument that provides information on gases and aerosols extending far beyond what can be derived from discrete-channel direct-beam measurements, while preserving or enhancing many of the desirable AATS features (e.g., compactness, versatility, automation, reliability). The enhanced instrument combines the sun-tracking ability of the current 14-Channel NASA Ames AATS-14 with the sky-scanning ability of the ground-based AERONET Sun/sky photometers, while extending both AATS-14 and AERONET capabilities by providing full spectral information from the UV (350 nm) to the SWIR (1,700 nm). Strengths of this measurement approach include many more wavelengths (isolated from gas absorption features) that may be used to characterize aerosols and detailed (oversampled) measurements of the absorption features of specific gas constituents. The Sky Scanning Sun Tracking Airborne Radiometer (3STAR) replicates the radiometer functionality of the AATS-14 instrument but incorporates modern COTS technologies for all instruments subsystems. A 19-channel radiometer bundle design is borrowed from a commercial water column radiance instrument manufactured by Biospherical Instruments of San Diego California (ref, Morrow and Hooker)) and developed using NASA funds under the Small Business Innovative Research (SBIR) program. The 3STAR design also incorporates the latest in robotic motor technology embodied in Rotary actuators from Oriental motor Corp. having better than 15 arc seconds of positioning accuracy. Control system was designed, tested and simulated using a Hybrid-Dynamical modeling methodology. The design also replaces the classic quadrant detector tracking sensor with a

  9. Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis.

    Science.gov (United States)

    Hayden, Lystra P; Cho, Michael H; McDonald, Merry-Lynn N; Crapo, James D; Beaty, Terri H; Silverman, Edwin K; Hersh, Craig P

    2017-01-01

    Previous studies have indicated that in adult smokers, a history of childhood pneumonia is associated with reduced lung function and chronic obstructive pulmonary disease. There have been few previous investigations using genome-wide association studies to investigate genetic predisposition to pneumonia. This study aims to identify the genetic variants associated with the development of pneumonia during childhood and over the course of the lifetime. Study subjects included current and former smokers with and without chronic obstructive pulmonary disease participating in the COPDGene Study. Pneumonia was defined by subject self-report, with childhood pneumonia categorized as having the first episode at pneumonia (843 cases, 9,091 control subjects) and lifetime pneumonia (3,766 cases, 5,659 control subjects) were performed separately in non-Hispanic whites and African Americans. Non-Hispanic white and African American populations were combined in the meta-analysis. Top genetic variants from childhood pneumonia were assessed in network analysis. No single-nucleotide polymorphisms reached genome-wide significance, although we identified potential regions of interest. In the childhood pneumonia analysis, this included variants in NGR1 (P = 6.3 × 10 -8 ), PAK6 (P = 3.3 × 10 -7 ), and near MATN1 (P = 2.8 × 10 -7 ). In the lifetime pneumonia analysis, this included variants in LOC339862 (P = 8.7 × 10 -7 ), RAPGEF2 (P = 8.4 × 10 -7 ), PHACTR1 (P = 6.1 × 10 -7 ), near PRR27 (P = 4.3 × 10 -7 ), and near MCPH1 (P = 2.7 × 10 -7 ). Network analysis of the genes associated with childhood pneumonia included top networks related to development, blood vessel morphogenesis, muscle contraction, WNT signaling, DNA damage, apoptosis, inflammation, and immune response (P ≤ 0.05). We have identified genes potentially associated with the risk of pneumonia. Further research will be required to confirm these

  10. An Open Access Database of Genome-wide Association Results

    Directory of Open Access Journals (Sweden)

    Johnson Andrew D

    2009-01-01

    Full Text Available Abstract Background The number of genome-wide association studies (GWAS is growing rapidly leading to the discovery and replication of many new disease loci. Combining results from multiple GWAS datasets may potentially strengthen previous conclusions and suggest new disease loci, pathways or pleiotropic genes. However, no database or centralized resource currently exists that contains anywhere near the full scope of GWAS results. Methods We collected available results from 118 GWAS articles into a database of 56,411 significant SNP-phenotype associations and accompanying information, making this database freely available here. In doing so, we met and describe here a number of challenges to creating an open access database of GWAS results. Through preliminary analyses and characterization of available GWAS, we demonstrate the potential to gain new insights by querying a database across GWAS. Results Using a genomic bin-based density analysis to search for highly associated regions of the genome, positive control loci (e.g., MHC loci were detected with high sensitivity. Likewise, an analysis of highly repeated SNPs across GWAS identified replicated loci (e.g., APOE, LPL. At the same time we identified novel, highly suggestive loci for a variety of traits that did not meet genome-wide significant thresholds in prior analyses, in some cases with strong support from the primary medical genetics literature (SLC16A7, CSMD1, OAS1, suggesting these genes merit further study. Additional adjustment for linkage disequilibrium within most regions with a high density of GWAS associations did not materially alter our findings. Having a centralized database with standardized gene annotation also allowed us to examine the representation of functional gene categories (gene ontologies containing one or more associations among top GWAS results. Genes relating to cell adhesion functions were highly over-represented among significant associations (p -14, a finding

  11. New Subarray Readout Patterns for the ACS Wide Field Channel

    Science.gov (United States)

    Golimowski, D.; Anderson, J.; Arslanian, S.; Chiaberge, M.; Grogin, N.; Lim, Pey Lian; Lupie, O.; McMaster, M.; Reinhart, M.; Schiffer, F.; Serrano, B.; Van Marshall, M.; Welty, A.

    2017-04-01

    At the start of Cycle 24, the original CCD-readout timing patterns used to generate ACS Wide Field Channel (WFC) subarray images were replaced with new patterns adapted from the four-quadrant readout pattern used to generate full-frame WFC images. The primary motivation for this replacement was a substantial reduction of observatory and staff resources needed to support WFC subarray bias calibration, which became a new and challenging obligation after the installation of the ACS CCD Electronics Box Replacement during Servicing Mission 4. The new readout patterns also improve the overall efficiency of observing with WFC subarrays and enable the processing of subarray images through stages of the ACS data calibration pipeline (calacs) that were previously restricted to full-frame WFC images. The new readout patterns replace the original 512×512, 1024×1024, and 2048×2046-pixel subarrays with subarrays having 2048 columns and 512, 1024, and 2048 rows, respectively. Whereas the original square subarrays were limited to certain WFC quadrants, the new rectangular subarrays are available in all four quadrants. The underlying bias structure of the new subarrays now conforms with those of the corresponding regions of the full-frame image, which allows raw frames in all image formats to be calibrated using one contemporaneous full-frame "superbias" reference image. The original subarrays remain available for scientific use, but calibration of these image formats is no longer supported by STScI.

  12. Wide-area SWIR arrays and active illuminators

    Science.gov (United States)

    MacDougal, Michael; Hood, Andrew; Geske, Jon; Wang, Chad; Renner, Daniel; Follman, David; Heu, Paula

    2012-01-01

    We describe the factors that go into the component choices for a short wavelength (SWIR) imager, which include the SWIR sensor, the lens, and the illuminator. We have shown the factors for reducing dark current, and shown that we can achieve well below 1.5 nA/cm2 for 15 μm devices at 7°C. We have mated our InGaAs detector arrays to 640x512 readout integrated integrated circuits (ROICs) to make focal plane arrays (FPAs). In addition, we have fabricated high definition 1920x1080 FPAs for wide field of view imaging. The resulting FPAs are capable of imaging photon fluxes with wavelengths between 1 and 1.6 microns at low light levels. The dark current associated with these FPAs is extremely low, exhibiting a mean dark current density of 0.26 nA/cm2 at 0°C. FLIR has also developed a high definition, 1920x1080, 15 um pitch SWIR sensor. In addition, FLIR has developed laser arrays that provide flat illumination in scenes that are normally light-starved. The illuminators have 40% wall-plug efficiency and provide low-speckle illumination, provide artifact-free imagery versus conventional laser illuminators.

  13. Histone Acetylome-wide Association Study of Autism Spectrum Disorder.

    Science.gov (United States)

    Sun, Wenjie; Poschmann, Jeremie; Cruz-Herrera Del Rosario, Ricardo; Parikshak, Neelroop N; Hajan, Hajira Shreen; Kumar, Vibhor; Ramasamy, Ramalakshmi; Belgard, T Grant; Elanggovan, Bavani; Wong, Chloe Chung Yi; Mill, Jonathan; Geschwind, Daniel H; Prabhakar, Shyam

    2016-11-17

    The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brains. Despite etiological heterogeneity, ≥68% of syndromic and idiopathic ASD cases shared a common acetylome signature at >5,000 cis-regulatory elements in prefrontal and temporal cortex. Similarly, multiple genes associated with rare genetic mutations in ASD showed common "epimutations." Acetylome aberrations in ASD were not attributable to genetic differentiation at cis-SNPs and highlighted genes involved in synaptic transmission, ion transport, epilepsy, behavioral abnormality, chemokinesis, histone deacetylation, and immunity. By correlating histone acetylation with genotype, we discovered >2,000 histone acetylation quantitative trait loci (haQTLs) in human brain regions, including four candidate causal variants for psychiatric diseases. Due to the relative stability of histone modifications postmortem, we anticipate that the HAWAS approach will be applicable to multiple diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Recent Advances in Wide-Bandgap Photovoltaic Polymers.

    Science.gov (United States)

    Cai, Yunhao; Huo, Lijun; Sun, Yanming

    2017-06-01

    The past decade has witnessed significant advances in the field of organic solar cells (OSCs). Ongoing improvements in the power conversion efficiency of OSCs have been achieved, which were mainly attributed to the design and synthesis of novel conjugated polymers with different architectures and functional moieties. Among various conjugated polymers, the development of wide-bandgap (WBG) polymers has received less attention than that of low-bandgap and medium-bandgap polymers. Here, we briefly summarize recent advances in WBG polymers and their applications in organic photovoltaic (PV) devices, such as tandem, ternary, and non-fullerene solar cells. Addtionally, we also dissuss the application of high open-circuit voltage tandem solar cells in PV-driven electrochemical water dissociation. We mainly focus on the molecular design strategies, the structure-property correlations, and the photovoltaic performance of these WBG polymers. Finally, we extract empirical regularities and provide invigorating perspectives on the future development of WBG photovoltaic materials. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Electronic materials with a wide band gap: recent developments

    Directory of Open Access Journals (Sweden)

    Detlef Klimm

    2014-09-01

    Full Text Available The development of semiconductor electronics is reviewed briefly, beginning with the development of germanium devices (band gap Eg = 0.66 eV after World War II. A tendency towards alternative materials with wider band gaps quickly became apparent, starting with silicon (Eg = 1.12 eV. This improved the signal-to-noise ratio for classical electronic applications. Both semiconductors have a tetrahedral coordination, and by isoelectronic alternative replacement of Ge or Si with carbon or various anions and cations, other semiconductors with wider Eg were obtained. These are transparent to visible light and belong to the group of wide band gap semiconductors. Nowadays, some nitrides, especially GaN and AlN, are the most important materials for optical emission in the ultraviolet and blue regions. Oxide crystals, such as ZnO and β-Ga2O3, offer similarly good electronic properties but still suffer from significant difficulties in obtaining stable and technologically adequate p-type conductivity.

  16. On Data Transfers Over Wide-Area Dedicated Connections

    Energy Technology Data Exchange (ETDEWEB)

    Rao, Nageswara S. [ORNL; Liu, Qiang [ORNL

    2018-01-01

    Dedicated wide-area network connections are employed in big data and high-performance computing scenarios, since the absence of cross-traffic promises to make it easier to analyze and optimize data transfers over them. However, nonlinear transport dynamics and end-system complexity due to multi-core hosts and distributed file systems make these tasks surprisingly challenging. We present an overview of methods to analyze memory and disk file transfers using extensive measurements over 10 Gbps physical and emulated connections with 0–366 ms round trip times (RTTs). For memory transfers, we derive performance profiles of TCP and UDT throughput as a function of RTT, which show concave regions in contrast to entirely convex regions predicted by previous models. These highly desirable concave regions can be expanded by utilizing large buffers and more parallel flows. We also present Poincar´e maps and Lyapunov exponents of TCP and UDT throughputtraces that indicate complex throughput dynamics. For disk file transfers, we show that throughput can be optimized using a combination of parallel I/O and network threads under direct I/O mode. Our initial throughput measurements of Lustre filesystems mounted over long-haul connections using LNet routers show convex profiles indicative of I/O limits.

  17. Genome-Wide Specific Selection in Three Domestic Sheep Breeds.

    Directory of Open Access Journals (Sweden)

    Huihua Wang

    Full Text Available Commercial sheep raised for mutton grow faster than traditional Chinese sheep breeds. Here, we aimed to evaluate genetic selection among three different types of sheep breed: two well-known commercial mutton breeds and one indigenous Chinese breed.We first combined locus-specific branch lengths and di statistical methods to detect candidate regions targeted by selection in the three different populations. The results showed that the genetic distances reached at least medium divergence for each pairwise combination. We found these two methods were highly correlated, and identified many growth-related candidate genes undergoing artificial selection. For production traits, APOBR and FTO are associated with body mass index. For meat traits, ALDOA, STK32B and FAM190A are related to marbling. For reproduction traits, CCNB2 and SLC8A3 affect oocyte development. We also found two well-known genes, GHR (which affects meat production and quality and EDAR (associated with hair thickness were associated with German mutton merino sheep. Furthermore, four genes (POL, RPL7, MSL1 and SHISA9 were associated with pre-weaning gain in our previous genome-wide association study.Our results indicated that combine locus-specific branch lengths and di statistical approaches can reduce the searching ranges for specific selection. And we got many credible candidate genes which not only confirm the results of previous reports, but also provide a suite of novel candidate genes in defined breeds to guide hybridization breeding.

  18. Genome-Wide Specific Selection in Three Domestic Sheep Breeds.

    Science.gov (United States)

    Wang, Huihua; Zhang, Li; Cao, Jiaxve; Wu, Mingming; Ma, Xiaomeng; Liu, Zhen; Liu, Ruizao; Zhao, Fuping; Wei, Caihong; Du, Lixin

    2015-01-01

    Commercial sheep raised for mutton grow faster than traditional Chinese sheep breeds. Here, we aimed to evaluate genetic selection among three different types of sheep breed: two well-known commercial mutton breeds and one indigenous Chinese breed. We first combined locus-specific branch lengths and di statistical methods to detect candidate regions targeted by selection in the three different populations. The results showed that the genetic distances reached at least medium divergence for each pairwise combination. We found these two methods were highly correlated, and identified many growth-related candidate genes undergoing artificial selection. For production traits, APOBR and FTO are associated with body mass index. For meat traits, ALDOA, STK32B and FAM190A are related to marbling. For reproduction traits, CCNB2 and SLC8A3 affect oocyte development. We also found two well-known genes, GHR (which affects meat production and quality) and EDAR (associated with hair thickness) were associated with German mutton merino sheep. Furthermore, four genes (POL, RPL7, MSL1 and SHISA9) were associated with pre-weaning gain in our previous genome-wide association study. Our results indicated that combine locus-specific branch lengths and di statistical approaches can reduce the searching ranges for specific selection. And we got many credible candidate genes which not only confirm the results of previous reports, but also provide a suite of novel candidate genes in defined breeds to guide hybridization breeding.

  19. Reconstructing Roma history from genome-wide data.

    Directory of Open Access Journals (Sweden)

    Priya Moorjani

    Full Text Available The Roma people, living throughout Europe and West Asia, are a diverse population linked by the Romani language and culture. Previous linguistic and genetic studies have suggested that the Roma migrated into Europe from South Asia about 1,000-1,500 years ago. Genetic inferences about Roma history have mostly focused on the Y chromosome and mitochondrial DNA. To explore what additional information can be learned from genome-wide data, we analyzed data from six Roma groups that we genotyped at hundreds of thousands of single nucleotide polymorphisms (SNPs. We estimate that the Roma harbor about 80% West Eurasian ancestry-derived from a combination of European and South Asian sources-and that the date of admixture of South Asian and European ancestry was about 850 years before present. We provide evidence for Eastern Europe being a major source of European ancestry, and North-west India being a major source of the South Asian ancestry in the Roma. By computing allele sharing as a measure of linkage disequilibrium, we estimate that the migration of Roma out of the Indian subcontinent was accompanied by a severe founder event, which appears to have been followed by a major demographic expansion after the arrival in Europe.

  20. Analysis of the most widely used Building Environmental Assessment methods

    International Nuclear Information System (INIS)

    Gu, Zhenhong; Wennersten, R.; Assefa, G.

    2006-01-01

    Building Environmental Assessment (BEA) is a term used for several methods for environmental assessment of the building environment. Generally, Life Cycle Assessment (LCA) is an important foundation and part of the BEA method, but current BEA methods form more comprehensive tools than LCA. Indicators and weight assignments are the two most important factors characterizing BEA. From the comparison of the three most widely used BEA methods, EcoHomes (BREEAM for residential buildings), LEED-NC and GBTool, it can be seen that BEA methods are shifting from ecological, indicator-based scientific systems to more integrated systems covering ecological, social and economic categories. Being relatively new methods, current BEA systems are far from perfect and are under continuous development. The further development of BEA methods will focus more on non-ecological indicators and how to promote implementation. Most BEA methods are developed based on regional regulations and LCA methods, but they do not attempt to replace these regulations. On the contrary, they try to extend implementation by incentive programmes. There are several ways to enhance BEA in the future: expand the studied scope from design levels to whole life-cycle levels of constructions, enhance international cooperation, accelerate legislation and standardize and develop user-oriented assessment systems

  1. Genome-wide association studies in Alzheimer's disease.

    Science.gov (United States)

    Bertram, Lars; Tanzi, Rudolph E

    2009-10-15

    Genome-wide association studies (GWAS) have gained considerable momentum over the last couple of years for the identification of novel complex disease genes. In the field of Alzheimer's disease (AD), there are currently eight published and two provisionally reported GWAS, highlighting over two dozen novel potential susceptibility loci beyond the well-established APOE association. On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1). Furthermore, consistent replication has been recently announced for CLU (clusterin, also known as apolipoprotein J). Finally, there are at least three replicated loci in hitherto uncharacterized genomic intervals on chromosomes 14q32.13, 14q31.2 and 6q24.1 likely implicating the existence of novel AD genes in these regions. In this review, we will discuss the characteristics and potential relevance to pathogenesis of the outcomes of all currently available GWAS in AD. A particular emphasis will be laid on findings with independent data in favor of the original association.

  2. Simulation of push-pull inverter using wide bandgap devices

    Science.gov (United States)

    Al-badri, Mustafa; Matin, Mohammed A.

    2016-09-01

    This paper discusses the use of wide bandgap devices (SiC-MOSFET) in the design of a push-pull inverter which provides inexpensive low power dc-ac inverters. The parameters used were 1200V SiC MOSFET(C2M0040120D) made by power company ROHM. This modeling was created using parameters that were provided from a device datasheet. The spice model is provided by this company to study the effect of adding this component on push-pull inverter ordinary circuit and compared results between SiC MOSFET and silicon MOSFET (IRFP260M). The results focused on Vout and Vmos stability as well as on output power and MOSFET power loss because it is a very crucial aspect on DC-AC inverter design. These results are done using the National Instrument simulation program (Multisim 14). It was found that power loss is better in the 12 and 15 vdc inverter. The Vout in the SIC MOSFET circuit shows more stability in the high current low resistance load in comparison to the Silicon MOSFET circuit and this will improve the overall performance of the circuit.

  3. Highball: A high speed, reserved-access, wide area network

    Science.gov (United States)

    Mills, David L.; Boncelet, Charles G.; Elias, John G.; Schragger, Paul A.; Jackson, Alden W.

    1990-01-01

    A network architecture called Highball and a preliminary design for a prototype, wide-area data network designed to operate at speeds of 1 Gbps and beyond are described. It is intended for applications requiring high speed burst transmissions where some latency between requesting a transmission and granting the request can be anticipated and tolerated. Examples include real-time video and disk-disk transfers, national filestore access, remote sensing, and similar applications. The network nodes include an intelligent crossbar switch, but have no buffering capabilities; thus, data must be queued at the end nodes. There are no restrictions on the network topology, link speeds, or end-end protocols. The end system, nodes, and links can operate at any speed up to the limits imposed by the physical facilities. An overview of an initial design approach is presented and is intended as a benchmark upon which a detailed design can be developed. It describes the network architecture and proposed access protocols, as well as functional descriptions of the hardware and software components that could be used in a prototype implementation. It concludes with a discussion of additional issues to be resolved in continuing stages of this project.

  4. Performability indicators for the traffic analysis of wide area networks

    International Nuclear Information System (INIS)

    Tsopelas, Panagiotis; Platis, Agapios

    2003-01-01

    In connecting computing networks, reliability term is strongly related to the availability of connections of Wide Area networks (WANs) or Local Area networks (LANs). In this paper we will examine the network connections activity of a Greek University in order to provide two sources of information: The Quantity of Information Not Delivered (QIND) and the Information Flow Interruption (IFI). These indicators will provide us with the inference of information from observable characteristics of data flow(s), even when the data is encrypted or otherwise not directly available (traffic), which is lost due to failures or upgrades inside this network. The reliability analysis is obtained by collecting the network failures data (duration and frequency) and traffic (total and average) for a specified period of 1 year. It is assumed that the numerical analysis is based on the fact that the lifetime follows and exponential distribution (here as we are working on discrete time the distribution must be the geometric distribution). Hence a Markov chain model seems suitable for modelling the functioning of this system. An algorithm concentrates the results in a transition probability matrix and calculates the reward functions for the QIND/IFI indicators with the use of the power method. Finally, the application part provides an example of how final results can be used to evaluate the observed network

  5. WEBSLIDE: A "Virtual" Slide Projector Based on World Wide Web

    Science.gov (United States)

    Barra, Maria; Ferrandino, Salvatore; Scarano, Vittorio

    1999-03-01

    We present here the design key concepts of WEBSLIDE, a software project whose objective is to provide a simple, cheap and efficient solution for showing slides during lessons in computer labs. In fact, WEBSLIDE allows the video monitors of several client machines (the "STUDENTS") to be synchronously updated by the actions of a particular client machine, called the "INSTRUCTOR." The system is based on the World Wide Web and the software components of WEBSLIDE mainly consists in a WWW server, browsers and small Cgi-Bill scripts. What makes WEBSLIDE particularly appealing for small educational institutions is that WEBSLIDE is built with "off the shelf" products: it does not involve using a specifically designed program but any Netscape browser, one of the most popular browsers available on the market, is sufficient. Another possible use is to use our system to implement "guided automatic tours" through several pages or Intranets internal news bulletins: the company Web server can broadcast to all employees relevant information on their browser.

  6. Genome-wide association study of proneness to anger.

    Directory of Open Access Journals (Sweden)

    Eric Mick

    Full Text Available Community samples suggest that approximately 1 in 20 children and adults exhibit clinically significant anger, hostility, and aggression. Individuals with dysregulated emotional control have a greater lifetime burden of psychiatric morbidity, severe impairment in role functioning, and premature mortality due to cardiovascular disease.With publically available data secured from dbGaP, we conducted a genome-wide association study of proneness to anger using the Spielberger State-Trait Anger Scale in the Atherosclerosis Risk in Communities (ARIC study (n = 8,747.Subjects were, on average, 54 (range 45-64 years old at baseline enrollment, 47% (n = 4,117 were male, and all were of European descent by self-report. The mean Angry Temperament and Angry Reaction scores were 5.8 ± 1.8 and 7.6 ± 2.2. We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected pgc = 2.2E-07, λ = 1.0015 on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3-gated channels to regulate calcium influx and intracellular release in the post-synaptic density. These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament.

  7. The world wide web: exploring a new advertising environment.

    Science.gov (United States)

    Johnson, C R; Neath, I

    1999-01-01

    The World Wide Web currently boasts millions of users in the United States alone and is likely to continue to expand both as a marketplace and as an advertising environment. Three experiments explored advertising in the Web environment, in particular memory for ads as they appear in everyday use across the Web. Experiments 1 and 2 examined the effect of advertising repetition on the retention of familiar and less familiar brand names, respectively. Experiment 1 demonstrated that repetition of a banner ad within multiple web pages can improve recall of familiar brand names, and Experiment 2 demonstrated that repetition can improve recognition of less familiar brand names. Experiment 3 directly compared the retention of familiar and less familiar brand names that were promoted by static and dynamic ads and demonstrated that the use of dynamic advertising can increase brand name recall, though only for familiar brand names. This study also demonstrated that, in the Web environment, much as in other advertising environments, familiar brand names possess a mnemonic advantage not possessed by less familiar brand names. Finally, data regarding Web usage gathered from all experiments confirm reports that Web usage among males tends to exceed that among females.

  8. Munchausen Syndrome and the Wide Spectrum of Factitious Disorders.

    Science.gov (United States)

    Tatu, Laurent; Aybek, Selma; Bogousslavsky, Julien

    2018-01-01

    Since its initial description in 1851, Munchausen syndrome has been widely used interchangeably with factitious disorder. Nevertheless, this syndrome is only one form of factitious disorder that is both severe and chronic. The syndrome was named after Karl Friedrich Hieronymus, Baron von Münchhausen (1720-1797), a German nobleman who became famous as a narrator of false and exaggerated exploits. His name was progressively corrupted to Munchausen. Factitious disorders and Munchausen syndrome remain a great diagnosis challenge for physicians. All medical specialities are concerned by these disorders. The diagnosis process involves a first step to exclude an unusual presentation of a common medical condition. The second step consists of excluding somatoform disorders and malingering. Unfortunately, the boundaries between factitious disorder, somatization, and malingering are often unclear. In 1977, the term "Munchausen's syndrome by proxy" was coined to define a situation where a person produces false symptoms in another one, especially a child. This term was extended to similar interactions between human and pets. Because varied conditions have been included in the definition of this syndrome, there is ongoing debate about alternative names. © 2018 S. Karger AG, Basel.

  9. Between the Sheets: a Library-wide Inventory with Google

    Directory of Open Access Journals (Sweden)

    Craig Boman

    2017-10-01

    Full Text Available When it comes to taking an inventory of physical items, libraries often rely on their traditional integrated library system’s (ILS à la carte add ons; outside vendors; or other possibly outdated, complex, and often expensive methods. For libraries with shrinking budgets and other limited resources, high costs can put these methods out of reach. At the University of Dayton Libraries, we set out to develop an inexpensive and reasonably easy-to-use method for conducting a library-wide physical item inventory. In this article, we explain a custom built Google Sheets-based library inventory system, along with some code for the implementation of a RESTful API (written in PHP that interacts with our ILS. We will also explain our use of Google Apps scripts in our Google Sheet, which are crucial to our systems. Although this method used a specific ILS (Innovative Interfaces' Sierra product and custom-built RESTful APIs, it may be possible to use similar approaches with other ILS software. Additional notes include areas for improvement and recommendations for interoperability with other ILS systems.

  10. Wide angle Compton scattering within the SCET factorization framework

    International Nuclear Information System (INIS)

    Kivel, N.

    2016-01-01

    Existing data for the electromagnetic proton form factors and for the cross section of the wide angle Compton scattering (WACS) show that the hard two-gluon exchange mechanism (collinear factorization) is still not applicable in the kinematical region where Mandelstam variables s ∼ -t ∼ -u are about a few GeV 2 . On the other hand these observables can be described in phenomenological models where spectator quarks are soft which assumes a large contribution due to the soft-overlap mechanism. It turns out that the simple QCD factorization picture is not complete and must also include the soft-overlap contribution which can be described as a certain matrix element in the soft collinear effective theory (SCET). Then the leading power contribution to WACS amplitude is described as a sum of the hard- and soft-spectator contributions. The existing experimental data allows one to check certain conclusions based on the assumption about dominant role of the soft-spectator mechanism. (author)

  11. Economy-wide impacts of biofuels in Argentina

    International Nuclear Information System (INIS)

    Timilsina, Govinda R.; Chisari, Omar O.; Romero, Carlos A.

    2013-01-01

    Argentina is one of the world's largest biodiesel producers and the largest exporter, using soybeans as feedstock. Using a computable general equilibrium model that explicitly represents the biofuel industry, this study carries out several simulations on two sets of issues: (i) international markets for biofuel and feedstock, such as an increase in prices of soybean, soybean oil, and biodiesel, and (ii) domestic policies related to biofuels, such as an introduction of biofuel mandates. Both sets of issues can have important consequences to the Argentinean economy. The simulations indicate that increases in international prices of biofuels and feedstocks would increase Argentina's gross domestic product and social welfare. Increases in international prices of ethanol and corn also can benefit Argentina, but to a lesser extent. The domestic mandates for biofuels, however, would cause small losses in economic output and social welfare because they divert part of biodiesel and feedstock from exports to lower-return domestic consumption. An increase in the export tax on either feedstock or biodiesel also would lead to a reduction in gross domestic product and social welfare, although government revenue would rise. - Highlights: ► Argentina is one of the largest biodiesel producer and exporter using soybeans. ► Economy-wide impacts are assessed using a CGE model for Argentina. ► Policies simulated are feedstock and biodiesel price change, and domestic mandates. ► Increases in international prices of biofuels and feedstock benefit the country. ► Domestic mandates for biofuels cause small losses in economic output

  12. THz Imaging by a Wide-band Compact FEL

    CERN Document Server

    Uk Jeong Young; Cheol Lee Byung; Hee-Park, S

    2004-01-01

    We have developed a laboratory-scale users facility with a compact THz FEL. The FEL operates in the wide wavelength range of 100–1200 μm, which corresponds to 0.3-3 THz. THz radiation from the FEL shows well collimated Gaussian spatial distribution and narrow spectral width of 0.3 μm, which is Fourier transform limited by the estimated pulse duration of 20 ps. The main application of the FEL is THz imaging for bio-medical researches. We are developing THz imaging techniques by 2-D scanning, single pulse capturing with the electro-optic method, and 3-D holography. High power, coherent, and pulsed feature of the FEL radiation is expected to show much better performance in advanced THz imaging of 3-D tomography by comparing with incoherent and weak THz sources. By controlling the optical delay between reference beam and scattered light from an object, we can get its 3-D tomography by the holograms. The coherent and pulse length of the FEL beam is measured to be 3-6 mm. In this paper we will show a...

  13. Wide-Field Astronomical Surveys in the Next Decade

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Michael A.; /Princeton U.; Tyson, J.Anthony; /UC, Davis; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Axelrod, T.S.; /LSST Corp.; Becker, Andrew C.; /Washington U., Seattle, Astron. Dept.; Bickerton, Steven J.; /Princeton U.; Blanton, Michael R.; /New York U.; Burke, David L.; /SLAC; Condon, J.J.; /NRAO, Socorro; Connolly, A.J.; /Washington U., Seattle, Astron. Dept.; Cooray, Asantha R.; /UC, Irvine; Covey, Kevin R.; /Harvard U.; Csabai, Istvan; /Eotvos U.; Ferguson, Henry C.; /Baltimore, Space Telescope Sci.; Ivezic, Zeljko; /Washington U., Seattle, Astron. Dept.; Kantor, Jeffrey; /LSST Corp.; Kent, Stephen M.; /Fermilab; Knapp, G.R.; /Princeton U.; Myers, Steven T.; /NRAO, Socorro; Neilsen, Eric H., Jr.; /Fermilab; Nichol, Robert C.; /Portsmouth U., ICG /Harish-Chandra Res. Inst. /Caltech, IPAC /Potsdam, Max Planck Inst. /Harvard U. /Hawaii U. /UC, Berkeley, Astron. Dept. /Baltimore, Space Telescope Sci. /NOAO, Tucson /Carnegie Mellon U. /Chicago U., Astron. Astrophys. Ctr.

    2011-11-14

    Wide-angle surveys have been an engine for new discoveries throughout the modern history of astronomy, and have been among the most highly cited and scientifically productive observing facilities in recent years. This trend is likely to continue over the next decade, as many of the most important questions in astrophysics are best tackled with massive surveys, often in synergy with each other and in tandem with the more traditional observatories. We argue that these surveys are most productive and have the greatest impact when the data from the surveys are made public in a timely manner. The rise of the 'survey astronomer' is a substantial change in the demographics of our field; one of the most important challenges of the next decade is to find ways to recognize the intellectual contributions of those who work on the infrastructure of surveys (hardware, software, survey planning and operations, and databases/data distribution), and to make career paths to allow them to thrive.

  14. Plant Mating Systems Often Vary Widely Among Populations

    Directory of Open Access Journals (Sweden)

    Michael R. Whitehead

    2018-04-01

    Full Text Available Most flowering plants are hermaphroditic, yet the proportion of seeds fertilized by self and outcross pollen varies widely among species, ranging from predominant self-fertilization to exclusive outcrossing. A population's rate of outcrossing has important evolutionary outcomes as it influences genetic structure, effective population size, and offspring fitness. Because most mating system studies have quantified outcrossing rates for just one or two populations, past reviews of mating system diversity have not been able to characterize the extent of variation among populations. Here we present a new database of more than 30 years of mating system studies that report outcrossing rates for three or more populations per species. This survey, which includes 741 populations from 105 species, illustrates substantial and prevalent among-population variation in the mating system. Intermediate outcrossing rates (mixed mating are common; 63% of species had at least one mixed mating population. The variance among populations and within species was not significantly correlated with pollination mode or phylogeny. Our review underscores the need for studies exploring variation in the relative influence of ecological and genetic factors on the mating system, and how this varies among populations. We conclude that estimates of outcrossing rates from single populations are often highly unreliable indicators of the mating system of an entire species.

  15. Probing dopants in wide semiconductor quantum point contacts

    International Nuclear Information System (INIS)

    Yakimenko, I I; Berggren, K-F

    2016-01-01

    Effects of randomly distributed impurities on conductance, spin polarization and electron localization in realistic gated semiconductor quantum point contacts (QPCs) have been simulated numerically. To this end density functional theory in the local spin-density approximation has been used. In the case when the donor layer is embedded far from the two-dimensional electron gas (2DEG) the electrostatic confinement potential exhibits the conventional parabolic form, and thus the usual ballistic transport phenomena take place both in the devices with split gates alone and with an additional metallic gate on the top. In the opposite case, i.e. when the randomly distributed donors are placed not far away from the 2DEG layer, there are drastic changes like the localization of electrons in the vicinity of confinement potential minima which give rise to fluctuations in conductance and resonances. The conductance as a function of the voltage applied to the top gate for asymmetrically charged split gates has been calculated. In this case resonances in conductance caused by randomly distributed donors are shifted and decrease in amplitude while the anomalies caused by interaction effects remain unmodified. It has been also shown that for a wide QPC the polarization can appear in the form of stripes. The importance of partial ionization of the random donors and the possibility of short range order among the ionized donors are emphasized. The motivation for this work is to critically evaluate the nature of impurities and how to guide the design of high-mobility devices. (paper)

  16. Wide range optofluidically tunable multimode interference fiber laser

    International Nuclear Information System (INIS)

    Antonio-Lopez, J E; LiKamWa, P; Sanchez-Mondragon, J J; May-Arrioja, D A

    2014-01-01

    An optofluidically tunable fiber laser based on multimode interference (MMI) effects with a wide tuning range is proposed and demonstrated. The tunable mechanism is based on an MMI fiber filter fabricated using a special fiber known as no-core fiber, which is a multimode fiber (MMF) without cladding. Therefore, when the MMI filter is covered by liquid the optical properties of the no-core fiber are modified, which allow us to tune the peak wavelength response of the MMI filter. Rather than applying the liquid on the entire no-core fiber, we change the liquid level along the no-core fiber, which provides a highly linear tuning response. In addition, by selecting the adequate refractive index of the liquid we can also choose the tuning range. We demonstrate the versatility of the optofluidically tunable MMI filter by wavelength tuning two different gain media, erbium doped fiber and a semiconductor optical amplifier, achieving tuning ranges of 55 and 90 nm respectively. In both cases, we achieve side-mode suppression ratios (SMSR) better than 50 dBm with output power variations of less than 0.76 dBm over the whole tuning range. (paper)

  17. Spatial characterization of the edge barrier in wide superconducting films

    Science.gov (United States)

    Sivakov, A. G.; Turutanov, O. G.; Kolinko, A. E.; Pokhila, A. S.

    2018-03-01

    The current-induced destruction of superconductivity is discussed in wide superconducting thin films, whose width is greater than the magnetic field penetration depth, in weak magnetic fields. Particular attention is paid to the role of the boundary potential barrier (the Bin-Livingston barrier) in critical state formation and detection of the edge responsible for this critical state with different mutual orientations of external perpendicular magnetic field and transport current. Critical and resistive states of the film were visualized using the space-resolving low-temperature laser scanning microscopy (LTLSM) method, which enables detection of critical current-determining areas on the film edges. Based on these observations, a simple technique was developed for investigation of the critical state separately at each film edge, and for the estimation of residual magnetic fields in cryostats. The proposed method only requires recording of the current-voltage characteristics of the film in a weak magnetic field, thus circumventing the need for complex LTLSM techniques. Information thus obtained is particularly important for interpretation of studies of superconducting film single-photon light emission detectors.

  18. Development of wide area environment accelerator operation and diagnostics method

    Science.gov (United States)

    Uchiyama, Akito; Furukawa, Kazuro

    2015-08-01

    Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs), the use of standard protocols such as the hypertext transfer protocol (HTTP) is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN) faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  19. State-wide performance criteria for international safeguards

    International Nuclear Information System (INIS)

    Budlong-Sylvester, K.W.; Pilat, Joseph F.; Stanbro, W.D.

    2001-01-01

    Traditionally, the International Atomic Energy Agency (IAEA) has relied upon prescriptive criteria to guide safeguards implementation. The prospect of replacing prescriptive safeguards criteria with more flexible performance criteria would constitute a structural change in safeguards and raises several important questions. Performance criteria imply that while safeguards goals will be fixed, the means of attaining those goals will not be explicitly prescribed. What would the performance objectives be under such a system? How would they be formulated? How would performance be linked to higher level safeguards objectives? How would safeguards performance be measured State-wide? The implementation of safeguards under performance criteria would also signal a dramatic change in the manner the Agency does business. A higher degree of flexibility could, in principle, produce greater effectiveness and efficiency, but would come with a need for increased Agency responsibility in practice. To the extent that reliance on prescriptive criteria decreases, the burden of justifying actions and ensuring their transparency will rise. Would there need to be limits to safeguards implementation? What would be the basis for setting such limits? This paper addresses these and other issues and questions relating to both the formulation and the implementation of performance-based criteria.

  20. Transcriptome-wide patterns of divergence during allopatric evolution.

    Science.gov (United States)

    Pereira, Ricardo J; Barreto, Felipe S; Pierce, N Tessa; Carneiro, Miguel; Burton, Ronald S

    2016-04-01

    Recent studies have revealed repeated patterns of genomic divergence associated with species formation. Such patterns suggest that natural selection tends to target a set of available genes, but is also indicative that closely related taxa share evolutionary constraints that limit genetic variability. Studying patterns of genomic divergence among populations within the same species may shed light on the underlying evolutionary processes. Here, we examine transcriptome-wide divergence and polymorphism in the marine copepod Tigriopus californicus, a species where allopatric evolution has led to replicate sets of populations with varying degrees of divergence and hybrid incompatibility. Our analyses suggest that relatively small effective population sizes have resulted in an exponential decline of shared polymorphisms during population divergence and also facilitated the fixation of slightly deleterious mutations within allopatric populations. Five interpopulation comparisons at three different stages of divergence show that nonsynonymous mutations tend to accumulate in a specific set of proteins. These include proteins with central roles in cellular metabolism, such as those encoded in mtDNA, but also include an additional set of proteins that repeatedly show signatures of positive selection during allopatric divergence. Although our results are consistent with a contribution of nonadaptive processes, such as genetic drift and gene expression levels, generating repeatable patterns of genomic divergence in closely related taxa, they also indicate that adaptive evolution targeting a specific set of genes contributes to this pattern. Our results yield insights into the predictability of evolution at the gene level. © 2016 John Wiley & Sons Ltd.

  1. Thermodynamic performance analysis of ramjet engine at wide working conditions

    Science.gov (United States)

    Ou, Min; Yan, Li; Tang, Jing-feng; Huang, Wei; Chen, Xiao-qian

    2017-03-01

    Although ramjet has the advantages of high-speed flying and higher specific impulse, the performance parameters will decline seriously with the increase of flight Mach number and flight height. Therefore, the investigation on the thermodynamic performance of ramjet is very crucial for broadening the working range. In the current study, a typical ramjet model has been employed to investigate the performance characteristics at wide working conditions. First of all, the compression characteristic analysis is carried out based on the Brayton cycle. The obtained results show that the specific cross-section area (A2 and A5) and the air-fuel ratio (f) have a great influence on the ramjet performance indexes. Secondly, the thermodynamic calculation process of ramjet is given from the view of the pneumatic thermal analysis. Then, the variable trends of the ramjet performance indexes with the flow conditions, the air-fuel ratio (f), the specific cross-sectional area (A2 and A5) under the fixed operating condition, equipotential dynamic pressure condition and variable dynamic pressure condition have been discussed. Finally, the optimum value of the specific cross-sectional area (A5) and the air-fuel ratio (f) of the ramjet model at a fixed work condition (Ma=3.5, H=12 km) are obtained.

  2. Thermodynamic Property Model of Wide-Fluid Phase Propane

    Directory of Open Access Journals (Sweden)

    I Made Astina

    2007-05-01

    Full Text Available A new thermodynamic property model for propane is expressed in form of the Helmholtz free energy function. It consists of eight terms of the ideal-gas part and eighteen terms of the residual part. Accurate experimental data of fluid properties and theoretical approach from the intermolecular potential were simultaneously considered in the development to insure accuracy and to improve reliability of the equation of state over wide range of pressures and temperatures. Based on the state range of experimental data used in the model development, the validity range is judged from the triple-point of 85.48 K to temperature of 450 K and pressure up to 60 MPa. The uncertainties with respect to different properties are estimated to be 0.03% in ideal-gas isobaric specific heat, 0.2% in liquid phase density, 0.3% in gaseous phase density 1% in specific heats, 0.1% in vapor-pressure except at very low temperatures, 0.05% in saturated-liquid density, 0.02% in speed of sound of the gaseous phase and 1% in speed of sound of the liquid phase.

  3. Anhydrous crystals of DNA bases are wide gap semiconductors.

    Science.gov (United States)

    Maia, F F; Freire, V N; Caetano, E W S; Azevedo, D L; Sales, F A M; Albuquerque, E L

    2011-05-07

    We present the structural, electronic, and optical properties of anhydrous crystals of DNA nucleobases (guanine, adenine, cytosine, and thymine) found after DFT (Density Functional Theory) calculations within the local density approximation, as well as experimental measurements of optical absorption for powders of these crystals. Guanine and cytosine (adenine and thymine) anhydrous crystals are predicted from the DFT simulations to be direct (indirect) band gap semiconductors, with values 2.68 eV and 3.30 eV (2.83 eV and 3.22 eV), respectively, while the experimentally estimated band gaps we have measured are 3.83 eV and 3.84 eV (3.89 eV and 4.07 eV), in the same order. The electronic effective masses we have obtained at band extremes show that, at low temperatures, these crystals behave like wide gap semiconductors for electrons moving along the nucleobases stacking direction, while the hole transport are somewhat limited. Lastly, the calculated electronic dielectric functions of DNA nucleobases crystals in the parallel and perpendicular directions to the stacking planes exhibit a high degree of anisotropy (except cytosine), in agreement with published experimental results.

  4. Study of Wide Swath Synthetic Aperture Ladar Imaging Techology

    Directory of Open Access Journals (Sweden)

    Zhang Keshu

    2017-02-01

    Full Text Available Combining synthetic-aperture imaging and coherent-light detection technology, the weak signal identification capacity of Synthetic Aperture Ladar (SAL reaches the photo level, and the image resolution exceeds the diffraction limit of the telescope to obtain high-resolution images irrespective to ranges. This paper introduces SAL, including the development path, technology characteristics, and the restriction of imaging swath. On the basis of this, we propose to integrate the SAL technology for extending its swath. By analyzing the scanning-operation mode and the signal model, the paper explicitly proposes that the former mode will be the developmental trend of the SAL technology. This paper also introduces the flight demonstrations of the SAL and the imaging results of remote targets, showing the potential of the SAL in long-range, high-resolution, and scanning-imaging applications. The technology and the theory of the scanning mode of SAL compensates for the defects related to the swath and operation efficiency of the current SAL. It provides scientific foundation for the SAL system applied in wide swath, high resolution earth observation, and the ISAL system applied in space-targets imaging.

  5. Modal density of rectangular structures in a wide frequency range

    Science.gov (United States)

    Parrinello, A.; Ghiringhelli, G. L.

    2018-04-01

    A novel approach to investigate the modal density of a rectangular structure in a wide frequency range is presented. First, the modal density is derived, in the whole frequency range of interest, on the basis of sound transmission through the infinite counterpart of the structure; then, it is corrected by means of the low-frequency modal behavior of the structure, taking into account actual size and boundary conditions. A statistical analysis reveals the connection between the modal density of the structure and the transmission of sound through its thickness. A transfer matrix approach is used to compute the required acoustic parameters, making it possible to deal with structures having arbitrary stratifications of different layers. A finite element method is applied on coarse grids to derive the first few eigenfrequencies required to correct the modal density. Both the transfer matrix approach and the coarse grids involved in the finite element analysis grant high efficiency. Comparison with alternative formulations demonstrates the effectiveness of the proposed methodology.

  6. Facility-wide synchronization of standard FAIR equipment controllers

    International Nuclear Information System (INIS)

    Rauch, S.; Terpstra, W.; Panschow, W.; Thieme, M.; Prados, C.; Zweig, M.; Kreider, M.; Beck, D.; Bär, R.

    2012-01-01

    The standard equipment controller under development for the new FAIR accelerator facility is the Scalable Control Unit (SCU). It is designed to synchronize and control the actions of up to 12 purpose-built slave cards, connected in a proprietary crate by a parallel backplane. Inter-crate coordination and facility-wide synchronization are a core FAIR requirement and thus precise timing of SCU slave actions is of vital importance. The SCU consists primarily of two components, an x86 COM Express daughter board and a carrier board with an Altera Arria II GX FPGA, interconnected by PCI Express. The x86 receives configuration and set values with which it programs the real-time event-condition-action (ECA) unit in the FPGA. The ECA unit receives event messages via the timing network, which also synchronizes the clocks of all SCUs in the facility using White Rabbit. Matching events trigger actions on the SCU slave cards such as: ramping magnets, triggering kickers, etc. Timing requirements differ depending on the action taken. For softer real-time actions, an interrupt can be generated for complex processing on the x86. Alternatively, the FPGA can directly fire a pulse out a LEMO output or an immediate SCU bus operation. The delay and synchronization achievable in each case differs and this paper examines the timing performance of each to determine which approach is appropriate for the required actions. (author)

  7. MIMAS, setting the world-wide standard for plutonium recycling

    International Nuclear Information System (INIS)

    Vandergheynst Alain; Yvon Vanderborck

    2005-01-01

    Deployment of MIMAS MOX fuel irradiation started in 1985 with loading and irradiation in French 900 MWe PWR of EDF. A 20-year comprehensive R and D programme preceded it. This success was greatly facilitated by some early strategy advantages: 1) Development and licensing of a 'UO 2 -like' MOX fuel rod fully interchangeable with UO 2 rods; 2) Joint SCK/BN operation of the BR2 (MTR) and BR3 (PWR) reactors, pilot and industrial MOX fuel plants, PIE hot laboratories in the Mol/Dessel site. The period since 1985 saw the occurrence of some concurrent facts, that have incontestably led MIMAS to the world-wide leader position (99 % of actual MOX fuel is MIMAS): 1) BN-MIMAS has been selected by Cogema for its plants MELOX and Cadarache and has demonstrated to be a flexible, scalable, and industrial process. 2) MIMAS has been further selected by JNFL for its Japanese domestic MOX plant (Rokkasho-mura) and by US-DOE for its domestic MOX plant (Savannah-NC) for the disposition of 34-ton weapon-Pu. 3) Satisfactory fabrication and irradiation over 1840 metric tons of MIMAS MOX fuel. In order to face the worldwide on-going electricity market liberalisation, MIMAS makers and vendors must definitely improve the MOX performances to compete with continuously improving UO 2 fuel. The facing of this continuous challenge is also reviewed in the paper. (authors)

  8. Infant Gastroesophageal Reflux Information on the World Wide Web.

    Science.gov (United States)

    Balgowan, Regina; Greer, Leah C; D'Auria, Jennifer P

    2016-01-01

    The purpose of this study was to describe the type and quality of health information about infant gastroesophageal reflux (GER) that a parent may find on the World Wide Web. The data collection tool included evaluation of Web site quality and infant GER-specific content on the 30 sites that met the inclusion criteria. The most commonly found content categories in order of frequency were management strategies, when to call a primary care provider, definition, and clinical features. The most frequently mentioned strategies included feeding changes, infant positioning, and medications. Thirteen of the 30 Web sites included information on both GER and gastroesophageal reflux disease. Mention of the use of medication to lessen infant symptoms was found on 15 of the 30 sites. Only 10 of the 30 sites included information about parent support and coping strategies. Pediatric nurse practitioners (PNPs) should utilize well-child visits to address the normalcy of physiologic infant GER and clarify any misperceptions parents may have about diagnosis and the role of medication from information they may have found on the Internet. It is critical for PNPs to assist in the development of Web sites with accurate content, advise parents on how to identify safe and reliable information, and provide examples of high-quality Web sites about child health topics such as infant GER. Copyright © 2016 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

  9. Information on infantile colic on the World Wide Web.

    Science.gov (United States)

    Bailey, Shana D; D'Auria, Jennifer P; Haushalter, Jamie P

    2013-01-01

    The purpose of this study was to explore and describe the type and quality of information on infantile colic that a parent might access on the World Wide Web. Two checklists were used to evaluate the quality indicators of 24 Web sites and the colic-specific content. Fifteen health information Web sites met more of the quality parameters than the nine commercial sites. Eight Web sites included information about colic and infant abuse, with six being health information sites. The colic-specific content on 24 Web sites reflected current issues and controversies; however, the completeness of the information in light of current evidence varied among the Web sites. Strategies to avoid complications of parental stress or infant abuse were not commonly found on the Web sites. Pediatric professionals must guide parents to reliable colic resources that also include emotional support and understanding of infant crying. A best evidence guideline for the United States would eliminate confusion and uncertainty about which colic therapies are safe and effective for parents and professionals. Copyright © 2013 National Association of Pediatric Nurse Practitioners. Published by Mosby, Inc. All rights reserved.

  10. Non-mydriatic, wide field, fundus video camera

    Science.gov (United States)

    Hoeher, Bernhard; Voigtmann, Peter; Michelson, Georg; Schmauss, Bernhard

    2014-02-01

    We describe a method we call "stripe field imaging" that is capable of capturing wide field color fundus videos and images of the human eye at pupil sizes of 2mm. This means that it can be used with a non-dilated pupil even with bright ambient light. We realized a mobile demonstrator to prove the method and we could acquire color fundus videos of subjects successfully. We designed the demonstrator as a low-cost device consisting of mass market components to show that there is no major additional technical outlay to realize the improvements we propose. The technical core idea of our method is breaking the rotational symmetry in the optical design that is given in many conventional fundus cameras. By this measure we could extend the possible field of view (FOV) at a pupil size of 2mm from a circular field with 20° in diameter to a square field with 68° by 18° in size. We acquired a fundus video while the subject was slightly touching and releasing the lid. The resulting video showed changes at vessels in the region of the papilla and a change of the paleness of the papilla.

  11. Development of wide area environment accelerator operation and diagnostics method

    Directory of Open Access Journals (Sweden)

    Akito Uchiyama

    2015-08-01

    Full Text Available Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs, the use of standard protocols such as the hypertext transfer protocol (HTTP is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  12. Genome-wide identification of KANADI1 target genes.

    Directory of Open Access Journals (Sweden)

    Paz Merelo

    Full Text Available Plant organ development and polarity establishment is mediated by the action of several transcription factors. Among these, the KANADI (KAN subclade of the GARP protein family plays important roles in polarity-associated processes during embryo, shoot and root patterning. In this study, we have identified a set of potential direct target genes of KAN1 through a combination of chromatin immunoprecipitation/DNA sequencing (ChIP-Seq and genome-wide transcriptional profiling using tiling arrays. Target genes are over-represented for genes involved in the regulation of organ development as well as in the response to auxin. KAN1 affects directly the expression of several genes previously shown to be important in the establishment of polarity during lateral organ and vascular tissue development. We also show that KAN1 controls through its target genes auxin effects on organ development at different levels: transport and its regulation, and signaling. In addition, KAN1 regulates genes involved in the response to abscisic acid, jasmonic acid, brassinosteroids, ethylene, cytokinins and gibberellins. The role of KAN1 in organ polarity is antagonized by HD-ZIPIII transcription factors, including REVOLUTA (REV. A comparison of their target genes reveals that the REV/KAN1 module acts in organ patterning through opposite regulation of shared targets. Evidence of mutual repression between closely related family members is also shown.

  13. Psoriasis prediction from genome-wide SNP profiles

    Directory of Open Access Journals (Sweden)

    Fang Xiangzhong

    2011-01-01

    Full Text Available Abstract Background With the availability of large-scale genome-wide association study (GWAS data, choosing an optimal set of SNPs for disease susceptibility prediction is a challenging task. This study aimed to use single nucleotide polymorphisms (SNPs to predict psoriasis from searching GWAS data. Methods Totally we had 2,798 samples and 451,724 SNPs. Process for searching a set of SNPs to predict susceptibility for psoriasis consisted of two steps. The first one was to search top 1,000 SNPs with high accuracy for prediction of psoriasis from GWAS dataset. The second one was to search for an optimal SNP subset for predicting psoriasis. The sequential information bottleneck (sIB method was compared with classical linear discriminant analysis(LDA for classification performance. Results The best test harmonic mean of sensitivity and specificity for predicting psoriasis by sIB was 0.674(95% CI: 0.650-0.698, while only 0.520(95% CI: 0.472-0.524 was reported for predicting disease by LDA. Our results indicate that the new classifier sIB performs better than LDA in the study. Conclusions The fact that a small set of SNPs can predict disease status with average accuracy of 68% makes it possible to use SNP data for psoriasis prediction.

  14. High-Temperature, Wirebondless, Ultracompact Wide Bandgap Power Semiconductor Modules

    Science.gov (United States)

    Elmes, John

    2015-01-01

    Silicon carbide (SiC) and other wide bandgap semiconductors offer great promise of high power rating, high operating temperature, simple thermal management, and ultrahigh power density for both space and commercial power electronic systems. However, this great potential is seriously limited by the lack of reliable high-temperature device packaging technology. This Phase II project developed an ultracompact hybrid power module packaging technology based on the use of double lead frames and direct lead frame-to-chip transient liquid phase (TLP) bonding that allows device operation up to 450 degC. The new power module will have a very small form factor with 3-5X reduction in size and weight from the prior art, and it will be capable of operating from 450 degC to -125 degC. This technology will have a profound impact on power electronics and energy conversion technologies and help to conserve energy and the environment as well as reduce the nation's dependence on fossil fuels.

  15. Genome-Wide Association Studies of the Human Gut Microbiota.

    Directory of Open Access Journals (Sweden)

    Emily R Davenport

    Full Text Available The bacterial composition of the human fecal microbiome is influenced by many lifestyle factors, notably diet. It is less clear, however, what role host genetics plays in dictating the composition of bacteria living in the gut. In this study, we examined the association of ~200K host genotypes with the relative abundance of fecal bacterial taxa in a founder population, the Hutterites, during two seasons (n = 91 summer, n = 93 winter, n = 57 individuals collected in both. These individuals live and eat communally, minimizing variation due to environmental exposures, including diet, which could potentially mask small genetic effects. Using a GWAS approach that takes into account the relatedness between subjects, we identified at least 8 bacterial taxa whose abundances were associated with single nucleotide polymorphisms in the host genome in each season (at genome-wide FDR of 20%. For example, we identified an association between a taxon known to affect obesity (genus Akkermansia and a variant near PLD1, a gene previously associated with body mass index. Moreover, we replicate a previously reported association from a quantitative trait locus (QTL mapping study of fecal microbiome abundance in mice (genus Lactococcus, rs3747113, P = 3.13 x 10-7. Finally, based on the significance distribution of the associated microbiome QTLs in our study with respect to chromatin accessibility profiles, we identified tissues in which host genetic variation may be acting to influence bacterial abundance in the gut.

  16. Development of stable monolithic wide-field Michelson interferometers.

    Science.gov (United States)

    Wan, Xiaoke; Ge, Jian; Chen, Zhiping

    2011-07-20

    Bulk wide-field Michelson interferometers are very useful for high precision applications in remote sensing and astronomy. A stable monolithic Michelson interferometer is a key element in high precision radial velocity (RV) measurements for extrasolar planets searching and studies. Thermal stress analysis shows that matching coefficients of thermal expansion (CTEs) is a critical requirement for ensuring interferometer stability. This requirement leads to a novel design using BK7 and LAK7 materials, such that the monolithic interferometer is free from thermal distortion. The processes of design, fabrication, and testing of interferometers are described in detail. In performance evaluations, the field angle is typically 23.8° and thermal sensitivity is typically -2.6×10(-6)/°C near 550 nm, which corresponds to ∼800 m/s/°C in the RV scale. Low-cost interferometer products have been commissioned in multiple RV instruments, and they are producing high stability performance over long term operations. © 2011 Optical Society of America

  17. Wide field and diffraction limited array camera for SIRTF

    International Nuclear Information System (INIS)

    Fazio, G.G.; Koch, D.G.; Melnick, G.J.

    1986-01-01

    The Infrared Array Camera for the Space Infrared Telescope Facility (SIRTF/IRAC) is capable of two-dimensional photometry in either a wide field or diffraction-limited mode over the wavelength interval from 2 to 30 microns. Three different two-dimensional direct readout (DRO) array detectors are being considered: Band 1-InSb or Si:In (2-5 microns) 128 x 128 pixels, Band 2-Si:Ga (5-18 microns) 64 x 64 pixels, and Band 3-Si:Sb (18-30 microns) 64 x 64 pixels. The hybrid DRO readout architecture has the advantages of low read noise, random pixel access with individual readout rates, and nondestructive readout. The scientific goals of IRAC are discussed, which are the basis for several important requirements and capabilities of the array camera: (1) diffraction-limited resolution from 2-30 microns, (2) use of the maximum unvignetted field of view of SIRTF, (3) simultaneous observations within the three infrared spectral bands, and (4) the capability for broad and narrow bandwidth spectral resolution. A strategy has been developed to minimize the total electronic and environmental noise sources to satisfy the scientific requirements. 7 references

  18. Assessing Predictive Properties of Genome-Wide Selection in Soybeans

    Directory of Open Access Journals (Sweden)

    Alencar Xavier

    2016-08-01

    Full Text Available Many economically important traits in plant breeding have low heritability or are difficult to measure. For these traits, genomic selection has attractive features and may boost genetic gains. Our goal was to evaluate alternative scenarios to implement genomic selection for yield components in soybean (Glycine max L. merr. We used a nested association panel with cross validation to evaluate the impacts of training population size, genotyping density, and prediction model on the accuracy of genomic prediction. Our results indicate that training population size was the factor most relevant to improvement in genome-wide prediction, with greatest improvement observed in training sets up to 2000 individuals. We discuss assumptions that influence the choice of the prediction model. Although alternative models had minor impacts on prediction accuracy, the most robust prediction model was the combination of reproducing kernel Hilbert space regression and BayesB. Higher genotyping density marginally improved accuracy. Our study finds that breeding programs seeking efficient genomic selection in soybeans would best allocate resources by investing in a representative training set.

  19. Assessing Predictive Properties of Genome-Wide Selection in Soybeans.

    Science.gov (United States)

    Xavier, Alencar; Muir, William M; Rainey, Katy Martin

    2016-08-09

    Many economically important traits in plant breeding have low heritability or are difficult to measure. For these traits, genomic selection has attractive features and may boost genetic gains. Our goal was to evaluate alternative scenarios to implement genomic selection for yield components in soybean (Glycine max L. merr). We used a nested association panel with cross validation to evaluate the impacts of training population size, genotyping density, and prediction model on the accuracy of genomic prediction. Our results indicate that training population size was the factor most relevant to improvement in genome-wide prediction, with greatest improvement observed in training sets up to 2000 individuals. We discuss assumptions that influence the choice of the prediction model. Although alternative models had minor impacts on prediction accuracy, the most robust prediction model was the combination of reproducing kernel Hilbert space regression and BayesB. Higher genotyping density marginally improved accuracy. Our study finds that breeding programs seeking efficient genomic selection in soybeans would best allocate resources by investing in a representative training set. Copyright © 2016 Xavie et al.

  20. Wide-band neutrino beams at 1000 GeV

    International Nuclear Information System (INIS)

    Malensek, A.; Stutte, L.

    1983-01-01

    In a previous publication, S. Mori discussed various broad-band neutrino and antineutrino beams using 1000 GeV protons on target. A new beam (SST) has been designed which provides the same neutrino flux as the quadrupole triplet (QT) while suppressing the wrong sign flux by a factor of 18. It also provides more than twice as much high energy antineutrino flux than the sign-selected bare target (SSBT) and in addition, has better neutrino suppression. While it is possible to increase the flux obtained from the single horn system over that previously described, the conclusion which states any horn focussing system seems to be of marginal use for Tevatron neutrino physics, is unchanged. Neutrino and antineutrino event rates and wrong sign backgrounds were computed using NUADA for a 100 metric ton detector of radius 1.5 meters. Due to radiation considerations and the existing transformer location, the horn beam is placed in its usual position inside the Target Tube. All other beams are placed in Fronthall. Thus, for the wide-band Fronthall trains a decay distance of 520 meters is used, versus 400 meters for the horn train

  1. Role of Librarian in Internet and World Wide Web Environment

    Directory of Open Access Journals (Sweden)

    K. Nageswara Rao

    2001-01-01

    Full Text Available The transition of traditional library collections to digital or virtual collections presented the librarian with new opportunities. The Internet, Web en-vironment and associated sophisticated tools have given the librarian a new dynamic role to play and serve the new information based society in bet-ter ways than hitherto. Because of the powerful features of Web i.e. distributed, heterogeneous, collaborative, multimedia, multi-protocol, hyperme-dia-oriented architecture, World Wide Web has revolutionized the way people access information, and has opened up new possibilities in areas such as digital libraries, virtual libraries, scientific information retrieval and dissemination. Not only the world is becoming interconnected, but also the use of Internet and Web has changed the fundamental roles, paradigms, and organizational culture of libraries and librarians as well. The article describes the limitless scope of Internet and Web, the existence of the librarian in the changing environment, parallelism between information sci-ence and information technology, librarians and intelligent agents, working of intelligent agents, strengths, weaknesses, threats and opportunities in-volved in the relationship between librarians and the Web. The role of librarian in Internet and Web environment especially as intermediary, facilita-tor, end-user trainer, Web site builder, researcher, interface designer, knowledge manager and sifter of information resources is also described.

  2. Drought Stress Responses of Sunflower Germplasm Developed after Wide Hybridization

    Directory of Open Access Journals (Sweden)

    Roumiana Dimova Vassilevska-Ivanova

    2016-10-01

    Full Text Available Response of sunflower germplasms viz. cultivated sunflower H. annuus and two breeding lines H. annuus x T. rotundifolia and H. annuus x V. encelioides developed after wide hybridization were used for identification of drought tolerant sunflower genotypes at the seedling growth stage. Three water stress levels of zero (control, -0.4, and -0.8 MPa were developed using polyethyleneglycol-6000 (PEG-6000. Physiological and biochemical stress determining parameters such as root and shoots length, fresh weight, antioxidant enzyme activities (superoxide dismutase (SOD, catalase (CAT, guaiacol peroxidase (GPO, ascorbate peroxidase (APX and antioxidant metabolite content (total antioxidant capacity, total phenols and total flavonoids content were compared between seedlings of all three genotypes. Results revealed that sunflower genotypes have similar responses at two osmotic potentials for shoot and root length and fresh weight. The data also showed that drought stresss could induce oxidative stress, as indicated by the increase level of ascorbate peroxidase and guaiacol peroxidase at -04 MPa in H. annuus cv 1114. Although the activity of ascorbate peroxidase and guaiacol peroxidase was differentially influenced by drought, the changes of antioxidant enzyme activities such as catalase, superoxide dismutase, guaiacol peroxidase, and ascorbate peroxidase subjected to drought stress follow a similar pattern in both breeding lines, indicating that similar defense systems might be involved in the oxidative stress injury in sunflowers. Increase in content of phenols and flavonoids were detected for all three genotypes under stress, which showed that these were major antioxidant metabolites in scavenging cellular H2O2.

  3. Multifunctional Antenna with Reconfigurable Ultra-Wide Band Characteristics

    Directory of Open Access Journals (Sweden)

    A. Verma

    2017-09-01

    Full Text Available In this paper a multifunctional antenna is presented which offers an ultra-wideband (UWB operation, an UWB operation with two switchable notches and reconfigurable dual-band operation for WiMAX and WLAN applications, respectively. Total seven functions/states could be achieved from a single antenna using an electronic switching. The antenna uses dual slots on the ground plane to provide a wide bandwidth, ranging from 3.1 GHz to 10.6 GHz. U-Shaped slot and C-Shaped printed strip in the ground are used to generate two notches at 3.6 GHz(WiMAX and 5.2 GHz (WLAN/ WiFi bands, respectively. Moreover, four parasitic strips are added in the feed side to make antenna functional at either3.6 GHz or 5.2 GHz or both. Total Five PIN diodes are required to obtain seven operations from the proposed antenna. Seven structures are fabricated and measured to verify the seven states and results are found in good agreement with estimated results obtained from the simulation.

  4. Multislot microstrip antenna for ultra-wide band applications

    Directory of Open Access Journals (Sweden)

    Noor M. Awad

    2018-01-01

    Full Text Available In this paper designs of both planar ultra-wide band (UWB antenna and UWB antenna with two rejected bands are given. The antenna consists of a rectangular patch etched on FR4-substrate with 50 Ω feed line. The rectangular patch has one round cut at each corner with one slot in the ground plane. The simulated bandwidth with return loss (RL ⩾ 10 dB is 3.42–11.7 GHz. The rejected bands are the WLAN and X-bands, achieved by inserting slots in the patch and the feed. The simulated results of the proposed antenna indicate higher gain at the passbands while a sharp drop at the rejected bands is seen. The radiation pattern is of dipole shape in the E-plane and almost omnidirectional in the H-plane. The high frequency structure simulator (HFSS is used to design and simulate the antennas behavior over the different frequency ranges. Measurements confirm the antenna characteristic as predicted in the simulation with a slight shift in frequencies.

  5. Training and Maintaining System-Wide Reliability in Outcome Management.

    Science.gov (United States)

    Barwick, Melanie A; Urajnik, Diana J; Moore, Julia E

    2014-01-01

    The Child and Adolescent Functional Assessment Scale (CAFAS) is widely used for outcome management, for providing real time client and program level data, and the monitoring of evidence-based practices. Methods of reliability training and the assessment of rater drift are critical for service decision-making within organizations and systems of care. We assessed two approaches for CAFAS training: external technical assistance and internal technical assistance. To this end, we sampled 315 practitioners trained by external technical assistance approach from 2,344 Ontario practitioners who had achieved reliability on the CAFAS. To assess the internal technical assistance approach as a reliable alternative training method, 140 practitioners trained internally were selected from the same pool of certified raters. Reliabilities were high for both practitioners trained by external technical assistance and internal technical assistance approaches (.909-.995, .915-.997, respectively). 1 and 3-year estimates showed some drift on several scales. High and consistent reliabilities over time and training method has implications for CAFAS training of behavioral health care practitioners, and the maintenance of CAFAS as a global outcome management tool in systems of care.

  6. System-wide Benefits of Intermeal Fasting by Autophagy.

    Science.gov (United States)

    Martinez-Lopez, Nuria; Tarabra, Elena; Toledo, Miriam; Garcia-Macia, Marina; Sahu, Srabani; Coletto, Luisa; Batista-Gonzalez, Ana; Barzilai, Nir; Pessin, Jeffrey E; Schwartz, Gary J; Kersten, Sander; Singh, Rajat

    2017-12-05

    Autophagy failure is associated with metabolic insufficiency. Although caloric restriction (CR) extends healthspan, its adherence in humans is poor. We established an isocaloric twice-a-day (ITAD) feeding model wherein ITAD-fed mice consume the same food amount as ad libitum controls but at two short windows early and late in the diurnal cycle. We hypothesized that ITAD feeding will provide two intervals of intermeal fasting per circadian period and induce autophagy. We show that ITAD feeding modifies circadian autophagy and glucose/lipid metabolism that correlate with feeding-driven changes in circulating insulin. ITAD feeding decreases adiposity and, unlike CR, enhances muscle mass. ITAD feeding drives energy expenditure, lowers lipid levels, suppresses gluconeogenesis, and prevents age/obesity-associated metabolic defects. Using liver-, adipose-, myogenic-, and proopiomelanocortin neuron-specific autophagy-null mice, we mapped the contribution of tissue-specific autophagy to system-wide benefits of ITAD feeding. Our studies suggest that consuming two meals a day without CR could prevent the metabolic syndrome. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Deepest Wide-Field Colour Image in the Southern Sky

    Science.gov (United States)

    2003-01-01

    LA SILLA CAMERA OBSERVES CHANDRA DEEP FIELD SOUTH ESO PR Photo 02a/03 ESO PR Photo 02a/03 [Preview - JPEG: 400 x 437 pix - 95k] [Normal - JPEG: 800 x 873 pix - 904k] [HiRes - JPEG: 4000 x 4366 pix - 23.1M] Caption : PR Photo 02a/03 shows a three-colour composite image of the Chandra Deep Field South (CDF-S) , obtained with the Wide Field Imager (WFI) camera on the 2.2-m MPG/ESO telescope at the ESO La Silla Observatory (Chile). It was produced by the combination of about 450 images with a total exposure time of nearly 50 hours. The field measures 36 x 34 arcmin 2 ; North is up and East is left. Technical information is available below. The combined efforts of three European teams of astronomers, targeting the same sky field in the southern constellation Fornax (The Oven) have enabled them to construct a very deep, true-colour image - opening an exceptionally clear view towards the distant universe . The image ( PR Photo 02a/03 ) covers an area somewhat larger than the full moon. It displays more than 100,000 galaxies, several thousand stars and hundreds of quasars. It is based on images with a total exposure time of nearly 50 hours, collected under good observing conditions with the Wide Field Imager (WFI) on the MPG/ESO 2.2m telescope at the ESO La Silla Observatory (Chile) - many of them extracted from the ESO Science Data Archive . The position of this southern sky field was chosen by Riccardo Giacconi (Nobel Laureate in Physics 2002) at a time when he was Director General of ESO, together with Piero Rosati (ESO). It was selected as a sky region towards which the NASA Chandra X-ray satellite observatory , launched in July 1999, would be pointed while carrying out a very long exposure (lasting a total of 1 million seconds, or 278 hours) in order to detect the faintest possible X-ray sources. The field is now known as the Chandra Deep Field South (CDF-S) . The new WFI photo of CDF-S does not reach quite as deep as the available images of the "Hubble Deep Fields

  8. Optical characterization of wide-gap detector-grade semiconductors

    International Nuclear Information System (INIS)

    Elshazly, E.S.

    2011-01-01

    Wide bandgap semiconductors are being widely investigated because they have the potential to satisfy the stringent material requirements of high resolution, room temperature gamma-ray spectrometers. In particular, Cadmium Zinc Telluride (Cd 1-x Zn x Te, x∼0.1) and Thallium Bromide (Tl Br), due to their combination of high resistivity, high atomic number and good electron mobility, have became very promising candidates for use in X- and gamma-ray detectors operating at room temperature. In this study, carrier trapping times were measured in CZT and Tl Br as a function of temperature and material quality. Carrier lifetimes and tellurium inclusion densities were measured in detector-grade Cadmium Zinc Telluride (CZT) crystals grown by the High Pressure Bridgman method and Modified Bridgman method. Excess carriers were produced in the material using a pulsed YAG laser with a 1064 nm wavelength and 7 ns pulse width. Infrared microscopy was used to measure the tellurium defect densities in CZT crystals. The electronic decay was optically measured at room temperature. Spatial mapping of lifetimes and defect densities in CZT was performed to determine the relationship between defect density and electronic decay. A significant and strong correlation was found between the volume fraction of tellurium inclusions and the carrier trapping time. Carrier trapping times and tellurium inclusions were measured in CZT in the temperature range from 300 K to 110 K and the results were analyzed using a theoretical trapping model. Spatial mapping of carrier trapping times and defect densities in CZT was performed to determine the relationship between defect density and electronic decay. While a strong correlation between trapping time and defect density of tellurium inclusions was observed, there was no significant change in the trap energy. Carrier trapping times were measured in detector grade thallium bromide (Tl Br) and compared with the results for cadmium zinc telluride (CZT) in

  9. A Genome-wide Association Study of Myasthenia Gravis

    Science.gov (United States)

    Renton, Alan E.; Pliner, Hannah A.; Provenzano, Carlo; Evoli, Amelia; Ricciardi, Roberta; Nalls, Michael A.; Marangi, Giuseppe; Abramzon, Yevgeniya; Arepalli, Sampath; Chong, Sean; Hernandez, Dena G.; Johnson, Janel O.; Bartoccioni, Emanuela; Scuderi, Flavia; Maestri, Michelangelo; Raphael Gibbs, J.; Errichiello, Edoardo; Chiò, Adriano; Restagno, Gabriella; Sabatelli, Mario; Macek, Mark; Scholz, Sonja W.; Corse, Andrea; Chaudhry, Vinay; Benatar, Michael; Barohn, Richard J.; McVey, April; Pasnoor, Mamatha; Dimachkie, Mazen M.; Rowin, Julie; Kissel, John; Freimer, Miriam; Kaminski, Henry J.; Sanders, Donald B.; Lipscomb, Bernadette; Massey, Janice M.; Chopra, Manisha; Howard, James F.; Koopman, Wilma J.; Nicolle, Michael W.; Pascuzzi, Robert M.; Pestronk, Alan; Wulf, Charlie; Florence, Julaine; Blackmore, Derrick; Soloway, Aimee; Siddiqi, Zaeem; Muppidi, Srikanth; Wolfe, Gil; Richman, David; Mezei, Michelle M.; Jiwa, Theresa; Oger, Joel; Drachman, Daniel B.; Traynor, Bryan J.

    2016-01-01

    IMPORTANCE Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology underlying myasthenia gravis is not well understood. OBJECTIVE To identify genetic variants that alter susceptibility to myasthenia gravis, we performed a genome-wide association study. DESIGN, SETTING, AND PARTICIPANTS DNA was obtained from 1032 white individuals from North America diagnosed as having acetylcholine receptor antibody–positive myasthenia gravis and 1998 race/ethnicity-matched control individuals from January 2010 to January 2011. These samples were genotyped on Illumina OmniExpress single-nucleotide polymorphism arrays. An independent cohort of 423 Italian cases and 467 Italian control individuals were used for replication. MAIN OUTCOMES AND MEASURES We calculated P values for association between 8114394 genotyped and imputed variants across the genome and risk for developing myasthenia gravis using logistic regression modeling. A threshold P value of 5.0 × 10−8 was set for genome-wide significance after Bonferroni correction for multiple testing. RESULTS In the over all case-control cohort, we identified association signals at CTLA4 (rs231770; P = 3.98 × 10−8; odds ratio, 1.37; 95% CI, 1.25–1.49), HLA-DQA1 (rs9271871; P = 1.08 × 10−8; odds ratio, 2.31; 95% CI, 2.02 – 2.60), and TNFRSF11A (rs4263037; P = 1.60 × 10−9; odds ratio, 1.41; 95% CI, 1.29–1.53). These findings replicated for CTLA4 and HLA-DQA1 in an independent cohort of Italian cases and control individuals. Further analysis revealed distinct, but overlapping, disease-associated loci for early- and late-onset forms of myasthenia gravis. In the late-onset cases, we identified 2 association peaks: one was located in TNFRSF11A (rs4263037; P = 1.32 × 10−12; odds ratio, 1.56; 95% CI, 1.44–1.68) and the other was detected

  10. Trapping guidelines for area-wide fruit fly programmes

    International Nuclear Information System (INIS)

    2003-11-01

    Different traps and lures have been developed and used over decades to survey fruit fly populations. The first attractant for male fruit flies was methyl eugenol (ME) (for Bactrocera zonata, Howlett, 1912) followed by kerosene for Mediterranean fruit fly, Ceratitis capitata, (medfly), Severin and Severin, 1913. In 1956, Angelica seed oil was used to trap medfly (Steiner et al, 1957). Beroza et al. (1961) discovered trimedlure (TML) to be effective for the same purpose. Beroza and Green, 1963, demonstrated cuelure to be an effective attractant for Bactrocera cucurbitae. Food baits based on protein solutions, fermenting sugar solutions, fruit juices, and vinegar have been used since 1918 for the capture of females of several species. The McPhail trap was the first device to be used with protein baits (McPhail, 1929). Steiner traps were developed in 1957 (Steiner et al., 1957) and Jackson traps in 1971 for TML (Harris et al., 1971). These traps are currently used in various countries for fruit fly surveys in support of control activities and eradication campaigns. The combination of a McPhail trap with a protein attractant, Jackson trap with TML, and the Steiner trap with ME or cuelure (CUE), has remained unchanged for several decades. Global trends in increasing food quality, revenue sources, and fruit and vegetable trade, has resulted in an increased worldwide movement of fruit fly species and requires refinement of survey systems. After years of validating trapping technology through coordinated research programmes (CRP's) and extensive technical assistance to member countries, the Joint Division FAO/IAEA proposes the use of proven technologies in improving trap sensitivity in area-wide fruit fly control programmes (IAEA 1996 and IAEA 1998). These proven technologies include the use of synthetic food lures such as female attractants that can be used for several species of Anastrepha, Bactrocera and Ceratitis. Other citations of information on these developments are

  11. Trapping guidelines for area-wide fruit fly programmes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-01

    Different traps and lures have been developed and used over decades to survey fruit fly populations. The first attractant for male fruit flies was methyl eugenol (ME) (for Bactrocera zonata, Howlett, 1912) followed by kerosene for Mediterranean fruit fly, Ceratitis capitata, (medfly), Severin and Severin, 1913. In 1956, Angelica seed oil was used to trap medfly (Steiner et al, 1957). Beroza et al. (1961) discovered trimedlure (TML) to be effective for the same purpose. Beroza and Green, 1963, demonstrated cuelure to be an effective attractant for Bactrocera cucurbitae. Food baits based on protein solutions, fermenting sugar solutions, fruit juices, and vinegar have been used since 1918 for the capture of females of several species. The McPhail trap was the first device to be used with protein baits (McPhail, 1929). Steiner traps were developed in 1957 (Steiner et al., 1957) and Jackson traps in 1971 for TML (Harris et al., 1971). These traps are currently used in various countries for fruit fly surveys in support of control activities and eradication campaigns. The combination of a McPhail trap with a protein attractant, Jackson trap with TML, and the Steiner trap with ME or cuelure (CUE), has remained unchanged for several decades. Global trends in increasing food quality, revenue sources, and fruit and vegetable trade, has resulted in an increased worldwide movement of fruit fly species and requires refinement of survey systems. After years of validating trapping technology through coordinated research programmes (CRP's) and extensive technical assistance to member countries, the Joint Division FAO/IAEA proposes the use of proven technologies in improving trap sensitivity in area-wide fruit fly control programmes (IAEA 1996 and IAEA 1998). These proven technologies include the use of synthetic food lures such as female attractants that can be used for several species of Anastrepha, Bactrocera and Ceratitis. Other citations of information on these developments are

  12. An Autonomous Data Reduction Pipeline for Wide Angle EO Systems

    Science.gov (United States)

    Privett, G.; George, S.; Feline, W.; Ash, A.; Routledge, G.

    The UK’s National Space and Security Policy states that the identification of potential on-orbit collisions and re-entry warning over the UK is of high importance, and is driving requirements for indigenous Space Situational Awareness (SSA) systems. To meet these requirements options are being examined, including the creation of a distributed network of simple, low cost commercial–off-the-shelf electro-optical sensors to support survey work and catalogue maintenance. This paper outlines work at Dstl examining whether data obtained using readily-deployable equipment could significantly enhance UK SSA capability and support cross-cueing between multiple deployed systems. To effectively exploit data from this distributed sensor architecture, a data handling system is required to autonomously detect satellite trails in a manner that pragmatically handles highly variable target intensities, periodicity and rates of apparent motion. The processing and collection strategies must be tailored to specific mission sets to ensure effective detections of platforms as diverse as stable geostationary satellites and low altitude CubeSats. Data captured during the Automated Transfer Vehicle-5 (ATV-5) de-orbit trial and images captured of a rocket body break up and a deployed deorbit sail have been employed to inform the development of a prototype processing pipeline for autonomous on-site processing. The approach taken employs tools such as Astrometry.Net and DAOPHOT from the astronomical community, together with image processing and orbit determination software developed inhouse by Dstl. Interim results from the automated analysis of data collected from wide angle sensors are described, together with the current perceived limitations of the proposed system and our plans for future development.

  13. Radiation resistance of wide-bandgap semiconductor power transistors

    Energy Technology Data Exchange (ETDEWEB)

    Hazdra, Pavel; Popelka, Stanislav [Department of Microelectronics, Czech Technical University in Prague (Czech Republic)

    2017-04-15

    Radiation resistance of state-of-the-art commercial wide-bandgap power transistors, 1700 V 4H-SiC power MOSFETs and 200 V GaN HEMTs, to the total ionization dose was investigated. Transistors were irradiated with 4.5 MeV electrons with doses up to 2000 kGy. Electrical characteristics and introduced defects were characterized by current-voltage (I-V), capacitance-voltage (C-V), and deep level transient spectroscopy (DLTS) measurements. Results show that already low doses of 4.5 MeV electrons (>1 kGy) cause a significant decrease in threshold voltage of SiC MOSFETs due to embedding of the positive charge into the gate oxide. On the other hand, other parameters like the ON-state resistance are nearly unchanged up to the dose of 20 kGy. At 200 kGy, the threshold voltage returns back close to its original value, however, the ON-state resistance increases and transconductance is lowered. This effect is caused by radiation defects introduced into the low-doped drift region which decrease electron concentration and mobility. GaN HEMTs exhibit significantly higher radiation resistance. They keep within the datasheet specification up to doses of 2000 kGy. Absence of dielectric layer beneath the gate and high concentration of carriers in the two dimensional electron gas channel are the reasons of higher radiation resistance of GaN HEMTs. Their degradation then occurs at much higher doses due to electron mobility degradation. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. World's Biggest Astronomy Event on the World-Wide

    Science.gov (United States)

    1996-06-01

    `Astronomy On-Line' will connect students all over Europe Astronomy On-Line is a major, all-European project that will take place in conjunction with the 4th European Week for Scientific and Technological Culture later this year. It is based on intensive use of the World-Wide-Web (WWW) and represents the first large-scale attempt in the world to bring together pupils and their teachers all over one continent to explore challenging scientific questions, using modern communication tools, both for obtaining and for communicating information. The programme will be carried out in a collaboration between the European Association for Astronomy Education (EAAE) [1] and the European Southern Observatory, and together with the European Commission (EC). The active phase of Astronomy On-Line will start on October 1 and reach a climax on November 18 - 22, 1996 . What is `Astronomy On-Line'? In this project, a large number of students and their teachers at schools all over Europe, together with professional and amateur astronomers and others interested in astronomy, will become associated in a unique experience that makes intensive use of the vast possibilities of the World-Wide-Web (WWW). Although the exact number of participants will not be known until the beginning of October, it is expected to run into thousands, possibly many more. The unusual size and scope of Astronomy On-Line will contribute to make it an important all-European media event. The central idea is that the participants, through the WWW, will `meet' in a `marketplace' where a number of different `shops' will be available, each of which will tempt them with a number of exciting and educational `events', carefully prepared to cater for different age groups, from 12 years upwards. The events will cover a wide spectrum of activities, some of which will be timed to ensure the proper progression of this very complex project through its main phases. The benefits In fact, Astronomy On-Line will be the first

  15. Tropical cyclone cooling combats region-wide coral bleaching.

    Science.gov (United States)

    Carrigan, Adam D; Puotinen, Marji

    2014-05-01

    Coral bleaching has become more frequent and widespread as a result of rising sea surface temperature (SST). During a regional scale SST anomaly, reef exposure to thermal stress is patchy in part due to physical factors that reduce SST to provide thermal refuge. Tropical cyclones (TCs - hurricanes, typhoons) can induce temperature drops at spatial scales comparable to that of the SST anomaly itself. Such cyclone cooling can mitigate bleaching across broad areas when well-timed and appropriately located, yet the spatial and temporal prevalence of this phenomenon has not been quantified. Here, satellite SST and historical TC data are used to reconstruct cool wakes (n=46) across the Caribbean during two active TC seasons (2005 and 2010) where high thermal stress was widespread. Upon comparison of these datasets with thermal stress data from Coral Reef Watch and published accounts of bleaching, it is evident that TC cooling reduced thermal stress at a region-wide scale. The results show that during a mass bleaching event, TC cooling reduced thermal stress below critical levels to potentially mitigate bleaching at some reefs, and interrupted natural warming cycles to slow the build-up of thermal stress at others. Furthermore, reconstructed TC wave damage zones suggest that it was rare for more reef area to be damaged by waves than was cooled (only 12% of TCs). Extending the time series back to 1985 (n = 314), we estimate that for the recent period of enhanced TC activity (1995-2010), the annual probability that cooling and thermal stress co-occur is as high as 31% at some reefs. Quantifying such probabilities across the other tropical regions where both coral reefs and TCs exist is vital for improving our understanding of how reef exposure to rising SSTs may vary, and contributes to a basis for targeting reef conservation. © 2014 John Wiley & Sons Ltd.

  16. Regular Topologies for Gigabit Wide-Area Networks. Volume 1

    Science.gov (United States)

    Shacham, Nachum; Denny, Barbara A.; Lee, Diane S.; Khan, Irfan H.; Lee, Danny Y. C.; McKenney, Paul

    1994-01-01

    In general terms, this project aimed at the analysis and design of techniques for very high-speed networking. The formal objectives of the project were to: (1) Identify switch and network technologies for wide-area networks that interconnect a large number of users and can provide individual data paths at gigabit/s rates; (2) Quantitatively evaluate and compare existing and proposed architectures and protocols, identify their strength and growth potentials, and ascertain the compatibility of competing technologies; and (3) Propose new approaches to existing architectures and protocols, and identify opportunities for research to overcome deficiencies and enhance performance. The project was organized into two parts: 1. The design, analysis, and specification of techniques and protocols for very-high-speed network environments. In this part, SRI has focused on several key high-speed networking areas, including Forward Error Control (FEC) for high-speed networks in which data distortion is the result of packet loss, and the distribution of broadband, real-time traffic in multiple user sessions. 2. Congestion Avoidance Testbed Experiment (CATE). This part of the project was done within the framework of the DARTnet experimental T1 national network. The aim of the work was to advance the state of the art in benchmarking DARTnet's performance and traffic control by developing support tools for network experimentation, by designing benchmarks that allow various algorithms to be meaningfully compared, and by investigating new queueing techniques that better satisfy the needs of best-effort and reserved-resource traffic. This document is the final technical report describing the results obtained by SRI under this project. The report consists of three volumes: Volume 1 contains a technical description of the network techniques developed by SRI in the areas of FEC and multicast of real-time traffic. Volume 2 describes the work performed under CATE. Volume 3 contains the source

  17. Wide-Temperature Electrolytes for Lithium-Ion Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qiuyan; Jiao, Shuhong; Luo, Langli; Ding, Michael S.; Zheng, Jianming; Cartmell, Samuel S.; Wang, Chong-Min; Xu, Kang; Zhang, Ji-Guang; Xu, Wu

    2017-05-26

    Formulating electrolytes with solvents of low freezing points and high dielectric constants is a direct approach to extend the service temperature range of lithium (Li)-ion batteries (LIBs), for which propylene carbonate (PC), ethyl methyl carbonate (EMC), diethyl carbonate (DEC), methyl butyrate (MB) are excellent candidates. In this work, we report such low temperature electrolyte formulations by optimizing the content of ethylene carbonate (EC) in the EC-PC-EMC ternary solvent system with LiPF6 salt and CsPF6 additive. An extended service temperature range from 40°C to 60°C was obtained in LIBs with lithium nickel cobalt aluminum mixed oxide (LiNi0.80Co0.15Al0.05O2, NCA) as cathode and graphite as anode. The discharge capacities at low temperatures and the cycle life at room and elevated temperatures were systematically investigated in association with the ionic conductivity and phase transition behaviors. The most promising electrolyte formulation was identified as 1.0 M LiPF6 in EC-PC-EMC (1:1:8 by wt.) with 0.05 M CsPF6, which was demonstrated in both coin cells of graphite||NCA and 1 Ah pouch cells of graphite||LiNi1/3Mn1/3Co1/3O2. This optimized electrolyte enables excellent wide-temperature performances, as evidenced by the 68% capacity retention at 40C and C/5 rate, and nearly identical stable cycle life at room and elevated temperatures up to 60C.

  18. Genome-wide identification of direct HBx genomic targets

    KAUST Repository

    Guerrieri, Francesca

    2017-02-17

    Background The Hepatitis B Virus (HBV) HBx regulatory protein is required for HBV replication and involved in HBV-related carcinogenesis. HBx interacts with chromatin modifying enzymes and transcription factors to modulate histone post-translational modifications and to regulate viral cccDNA transcription and cellular gene expression. Aiming to identify genes and non-coding RNAs (ncRNAs) directly targeted by HBx, we performed a chromatin immunoprecipitation sequencing (ChIP-Seq) to analyse HBV recruitment on host cell chromatin in cells replicating HBV. Results ChIP-Seq high throughput sequencing of HBx-bound fragments was used to obtain a high-resolution, unbiased, mapping of HBx binding sites across the genome in HBV replicating cells. Protein-coding genes and ncRNAs involved in cell metabolism, chromatin dynamics and cancer were enriched among HBx targets together with genes/ncRNAs known to modulate HBV replication. The direct transcriptional activation of genes/miRNAs that potentiate endocytosis (Ras-related in brain (RAB) GTPase family) and autophagy (autophagy related (ATG) genes, beclin-1, miR-33a) and the transcriptional repression of microRNAs (miR-138, miR-224, miR-576, miR-596) that directly target the HBV pgRNA and would inhibit HBV replication, contribute to HBx-mediated increase of HBV replication. Conclusions Our ChIP-Seq analysis of HBx genome wide chromatin recruitment defined the repertoire of genes and ncRNAs directly targeted by HBx and led to the identification of new mechanisms by which HBx positively regulates cccDNA transcription and HBV replication.

  19. Wide Spectrum of Traumatic Rhabdomyolysis in Earthquake Victims

    Directory of Open Access Journals (Sweden)

    Shahnaz Atabak

    2009-12-01

    Full Text Available In the natural disasters such as earthquake, based on severity of trauma, time under the rubble and quality/quantity of hydratation we will confront with a spectrum of traumatic rhabdomyolysis. In present study we evaluate victims of Bam earthquake to show different stage of muscle trauma, from minor trauma with almost normal level of muscle enzyme to those with moderate trauma leading to crush injury and finally to advanced crush syndrome. Questionnaire consisted of clinical, biochemical and demographic items was designed and completed by our research team retrospectively. We divided the patients to crush and non-crush and also crush injury and crush syndrome, and then compared aforementioned items between them. Clinical and laboratory data of 2962 hospitalized victims, with an average age of 28.4(SD14.2 years (range 1-90 were collected (40% female. 611 patients were affected with crush injury (20%. These were entrapped 2.2 hours longer than the others (P<0.001. Mean IV intake in first 5 days was 3.6(SD2.6 liters for these patients in compare with 2.5(SD1.4 liters for others (P<0.001. 200 cases showed complete feature of crush syndrome. Electrolyte imbalance and systemic complications were drastically increased in the worst patients with crush syndrome. In approach to crushed patients of natural disasters by attention to the wide spectrum of muscle damage and systemic problems, the stepwise management protocol based on severity of traumatic rhabdomyolysis is inevitable and warranted.

  20. Pilot projects and nation-wide immunization in India.

    Science.gov (United States)

    Haxton, D

    1984-01-01

    These studies identify possibilities for expanding immunization coverage in India and show that there have been positive experiences in going to scale with immunizationation at the district level. Reasons for success are discussed. The promotion of social awareness and participation through all available channels is of central importance. Continuing attention should be directed to vaccine supply and distribution systems, program management and manpower training, especially at the community level. There are many opportunities for extending involvement in immunization efforts and broad-spectrum programs beyond the confines of the health system, and for flexibility in program organization. Planning must incorporate political commitment as well as the provision of adequate financial resources. India launched the Expanded Program on Immunization (EPI) in 1978. 6 diseases are currently on the official schedule for progressive nation-wide immunization: tuberculosis, poliomyelitis, whooping cough, diptheria, tetanus and typhoid. The experiences of 3 efforts in Dewas, in Bidar, (2 rural areas), and in Delhi (an urban area) are covered. Immunization coverage before the intensive efforts did not exceed 30%. Major elements of program organization were: nonhealth sector political and administrative involvement from the state; multisectoral planning committees at different levels; household surveys to identify children to be immunized; training sessions for each category of workers; and strengthening the cold chain. Factors in operational design and implementation include: vaccination posts in the community; selection of acceptable vaccination days; reminders the day before vaccination; collection of children; immunization cards as a device for informing about next round; counteraction of side-effects; follow-up of drop-outs; monitoring for corrective action involving all participants; and formal evaluation by local medical colleges. Intensive immunization in the 3 pilot sites

  1. Genome accessibility is widely preserved and locally modulated during mitosis.

    Science.gov (United States)

    Hsiung, Chris C-S; Morrissey, Christapher S; Udugama, Maheshi; Frank, Christopher L; Keller, Cheryl A; Baek, Songjoon; Giardine, Belinda; Crawford, Gregory E; Sung, Myong-Hee; Hardison, Ross C; Blobel, Gerd A

    2015-02-01

    Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors and chromatin features remain associated with individual loci during mitosis originated the hypothesis that such mitotically retained molecular signatures could provide transcriptional memory through mitosis. To understand the role of chromatin structure in mitotic memory, we performed the first genome-wide comparison of DNase I sensitivity of chromatin in mitosis and interphase, using a murine erythroblast model. Despite chromosome condensation during mitosis visible by microscopy, the landscape of chromatin accessibility at the macromolecular level is largely unaltered. However, mitotic chromatin accessibility is locally dynamic, with individual loci maintaining none, some, or all of their interphase accessibility. Mitotic reduction in accessibility occurs primarily within narrow, highly DNase hypersensitive sites that frequently coincide with transcription factor binding sites, whereas broader domains of moderate accessibility tend to be more stable. In mitosis, proximal promoters generally maintain their accessibility more strongly, whereas distal regulatory elements tend to lose accessibility. Large domains of DNA hypomethylation mark a subset of promoters that retain accessibility during mitosis and across many cell types in interphase. Erythroid transcription factor GATA1 exerts site-specific changes in interphase accessibility that are most pronounced at distal regulatory elements, but has little influence on mitotic accessibility. We conclude that features of open chromatin are remarkably stable through mitosis, but are modulated at the level of individual genes and regulatory elements. © 2015 Hsiung et al.; Published by

  2. Genephony: a knowledge management tool for genome-wide research

    Directory of Open Access Journals (Sweden)

    Riva Alberto

    2009-09-01

    Full Text Available Abstract Background One of the consequences of the rapid and widespread adoption of high-throughput experimental technologies is an exponential increase of the amount of data produced by genome-wide experiments. Researchers increasingly need to handle very large volumes of heterogeneous data, including both the data generated by their own experiments and the data retrieved from publicly available repositories of genomic knowledge. Integration, exploration, manipulation and interpretation of data and information therefore need to become as automated as possible, since their scale and breadth are, in general, beyond the limits of what individual researchers and the basic data management tools in normal use can handle. This paper describes Genephony, a tool we are developing to address these challenges. Results We describe how Genephony can be used to manage large datesets of genomic information, integrating them with existing knowledge repositories. We illustrate its functionalities with an example of a complex annotation task, in which a set of SNPs coming from a genotyping experiment is annotated with genes known to be associated to a phenotype of interest. We show how, thanks to the modular architecture of Genephony and its user-friendly interface, this task can be performed in a few simple steps. Conclusion Genephony is an online tool for the manipulation of large datasets of genomic information. It can be used as a browser for genomic data, as a high-throughput annotation tool, and as a knowledge discovery tool. It is designed to be easy to use, flexible and extensible. Its knowledge management engine provides fine-grained control over individual data elements, as well as efficient operations on large datasets.

  3. Genome-wide association study of schizophrenia in Japanese population.

    Directory of Open Access Journals (Sweden)

    Kazuo Yamada

    Full Text Available Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits. Genetic variants should explain a considerable portion of the risk for schizophrenia, and genome-wide association study (GWAS is a potentially powerful tool for identifying the risk variants that underlie the disease. Here, we report the results of a three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach. Firstly, we examined 115,770 single nucleotide polymorphisms (SNPs in 120 patient-parents trio samples from Japanese schizophrenia pedigrees. In stage II, we evaluated 1,632 SNPs (1,159 SNPs of p<0.01 and 473 SNPs of p<0.05 that located in previously reported linkage regions. The second sample consisted of 1,012 case-control samples of Japanese origin. The most significant p value was obtained for the SNP in the ELAVL2 [(embryonic lethal, abnormal vision, Drosophila-like 2] gene located on 9p21.3 (p = 0.00087. In stage III, we scrutinized the ELAVL2 gene by genotyping gene-centric tagSNPs in the third sample set of 293 family samples (1,163 individuals of Chinese descent and the SNP in the gene showed a nominal association with schizophrenia in Chinese population (p = 0.026. The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology.

  4. Finding Emotional-Laden Resources on the World Wide Web

    Directory of Open Access Journals (Sweden)

    Diane Rasmussen Neal

    2011-03-01

    Full Text Available Some content in multimedia resources can depict or evoke certain emotions in users. The aim of Emotional Information Retrieval (EmIR and of our research is to identify knowledge about emotional-laden documents and to use these findings in a new kind of World Wide Web information service that allows users to search and browse by emotion. Our prototype, called Media EMOtion SEarch (MEMOSE, is largely based on the results of research regarding emotive music pieces, images and videos. In order to index both evoked and depicted emotions in these three media types and to make them searchable, we work with a controlled vocabulary, slide controls to adjust the emotions’ intensities, and broad folksonomies to identify and separate the correct resource-specific emotions. This separation of so-called power tags is based on a tag distribution which follows either an inverse power law (only one emotion was recognized or an inverse-logistical shape (two or three emotions were recognized. Both distributions are well known in information science. MEMOSE consists of a tool for tagging basic emotions with the help of slide controls, a processing device to separate power tags, a retrieval component consisting of a search interface (for any topic in combination with one or more emotions and a results screen. The latter shows two separately ranked lists of items for each media type (depicted and felt emotions, displaying thumbnails of resources, ranked by the mean values of intensity. In the evaluation of the MEMOSE prototype, study participants described our EmIR system as an enjoyable Web 2.0 service.

  5. Context effects on processing widely deviant sounds in newborn infants

    Directory of Open Access Journals (Sweden)

    Gábor Péter Háden

    2013-09-01

    Full Text Available Detecting and orienting towards sounds carrying new information is a crucial feature of the human brain that supports adaptation to the environment. Rare, acoustically widely deviant sounds presented amongst frequent tones elicit large event related brain potentials (ERPs in neonates. Here we tested whether these discriminative ERP responses reflect only the activation of fresh afferent neuronal populations (i.e., neuronal circuits not affected by the tones or they also index the processing of contextual mismatch between the rare and the frequent sounds.In two separate experiments, we presented sleeping newborns with 150 different environmental sounds and the same number of white noise bursts. Both sounds served either as deviants in an oddball paradigm with the frequent standard stimulus a tone (Novel/Noise deviant, or as the standard stimulus with the tone as deviant (Novel/Noise standard, or they were delivered alone with the same timing as the deviants in the oddball condition (Novel/Noise alone.Whereas the ERP responses to noise–deviants elicited similar responses as the same sound presented alone, the responses elicited by environmental sounds in the corresponding conditions morphologically differed from each other. Thus whereas the ERP response to the noise sounds can be explained by the different refractory state of stimulus specific neuronal populations, the ERP response to environmental sounds indicated context sensitive processing. These results provide evidence for an innate tendency of context dependent auditory processing as well as a basis for the different developmental trajectories of processing acoustical deviance and contextual novelty.

  6. Susceptibility to chronic mucus hypersecretion, a genome wide association study.

    Directory of Open Access Journals (Sweden)

    Akkelies E Dijkstra

    Full Text Available Chronic mucus hypersecretion (CMH is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA study of CMH in Caucasian populations.GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years. Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP.A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10(-6, OR = 1.17, located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1 on chromosome 3. The risk allele (G was associated with higher mRNA expression of SATB1 (4.3×10(-9 in lung tissue. Presence of CMH was associated with increased SATB1 mRNA expression in bronchial biopsies from COPD patients. SATB1 expression was induced during differentiation of primary human bronchial epithelial cells in culture.Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a cis-eQTL for SATB1, together with our additional observation that SATB1 expression increases during epithelial differentiation provide suggestive evidence that SATB1 is a gene that affects CMH.

  7. Genome-wide associations of gene expression variation in humans.

    Directory of Open Access Journals (Sweden)

    Barbara E Stranger

    2005-12-01

    Full Text Available The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis- to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.

  8. Genome-Wide Associations of Gene Expression Variation in Humans.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis- to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.

  9. Cell wide responses to low oxygen exposure in Desulfovibriovulgaris Hildenborough

    Energy Technology Data Exchange (ETDEWEB)

    Mukhopadhyay, A.; Redding, A.; Joachimiak, M.; Arkin, A.; Borglin, S.; Dehal, P.; Chakraborty, R.; Geller, J.; Hazen, T.; He, Q.; Joyner, D.; Martin, V.; Wall, J.; Yang, Z.; Zhou, J.; Keasling, J.

    2007-03-11

    The responses of the anaerobic, sulfate-reducing Desulfovibrio vulgaris Hildenborough to low oxygen exposure (0.1% O{sub 2}) were monitored via transcriptomics and proteomics. Exposure to 0.1% O{sub 2} caused a decrease in growth rate without affecting viability. A concerted up regulation in the predicted peroxide stress response regulon (PerR) genes was observed in response to the 0.1% O{sub 2} exposure. Several of these candidates also showed increases in protein abundance. Among the remaining small number of transcript changes was the up regulation of the predicted transmembrane tetraheme cytochrome c3 complex. Other known oxidative stress response candidates remained unchanged during this low O{sub 2} exposure. To fully understand the results of the 0.1% O{sub 2} exposure, transcriptomics and proteomics data were collected for exposure to air using a similar experimental protocol. In contrast to the 0.1% O{sub 2} exposure, air exposure was detrimental to both the growth rate and viability and caused dramatic changes at both the transcriptome and proteome levels. Interestingly, the transcripts of the predicted PerR regulon genes were down regulated during air exposure. Our results highlight the differences in the cell wide response to low and high O{sub 2} levels of in D. vulgaris and suggest that while exposure to air is highly detrimental to D. vulgaris, this bacterium can successfully cope with periodic exposure to low O{sub 2} levels in its environment.

  10. Effective inactivation of a wide range of viruses by pasteurization.

    Science.gov (United States)

    Gröner, Albrecht; Broumis, Connie; Fang, Randel; Nowak, Thomas; Popp, Birgit; Schäfer, Wolfram; Roth, Nathan J

    2018-01-01

    Careful selection and testing of plasma reduces the risk of blood-borne viruses in the starting material for plasma-derived products. Furthermore, effective measures such as pasteurization at 60°C for 10 hours have been implemented in the manufacturing process of therapeutic plasma proteins such as human albumin, coagulation factors, immunoglobulins, and enzyme inhibitors to inactivate blood-borne viruses of concern. A comprehensive compilation of the virus reduction capacity of pasteurization is presented including the effect of stabilizers used to protect the therapeutic protein from modifications during heat treatment. The virus inactivation kinetics of pasteurization for a broad range of viruses were evaluated in the relevant intermediates from more than 15 different plasma manufacturing processes. Studies were carried out under the routine manufacturing target variables, such as temperature and product-specific stabilizer composition. Additional studies were also performed under robustness conditions, that is, outside production specifications. The data demonstrate that pasteurization inactivates a wide range of enveloped and nonenveloped viruses of diverse physicochemical characteristics. After a maximum of 6 hours' incubation, no residual infectivity could be detected for the majority of enveloped viruses. Effective inactivation of a range of nonenveloped viruses, with the exception of nonhuman parvoviruses, was documented. Pasteurization is a very robust and reliable virus inactivation method with a broad effectiveness against known blood-borne pathogens and emerging or potentially emerging viruses. Pasteurization has proven itself to be a highly effective step, in combination with other complementary safety measures, toward assuring the virus safety of final product. © 2017 The Authors Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

  11. Low cost and thin metasurface for ultra wide band and wide angle polarization insensitive radar cross section reduction

    Science.gov (United States)

    Ameri, Edris; Esmaeli, Seyed Hassan; Sedighy, Seyed Hassan

    2018-05-01

    A planar low cost and thin metasurface is proposed to achieve ultra-wideband radar cross section (RCS) reduction with stable performance with respect to polarization and incident angles. This metasurface is composed of two different artificial magnetic conductor unit cells arranged in a chessboard like configuration. These unit cells have a Jerusalem cross pattern with different thicknesses, which results in wideband out-phase reflection and RCS reduction, consequently. The designed metasurface reduces RCS more than 10-dB from 13.6 GHz to 45.5 GHz (108% bandwidth) and more than 20-dB RCS from 15.2 GHz to 43.6 GHz (96.6%). Moreover, the 10-dB RCS reduction bandwidth is very stable (more than 107%) for both TE and TM polarizations. The good agreement between simulations and measurement results proves the design, properly. The ultra-wide bandwidth, low cost, low profile, and stable performance of this metasurface prove its high capability compared with the state-of-the-art references.

  12. A System-Wide Approach to Diabetic Nephropathy

    KAUST Repository

    Palafox, Luis

    2011-07-07

    Diabetes mellitus is a complex human disease that affects more than 280 million people worldwide. One of the diabetic long-term complications is diabetic nephropathy that it is responsible for 50% of all end-stage renal disease. The complexity of diabetes and the lack of comprehensive systematic studies have halted the development of drugs and clinical therapies for the treatment of diabetes and its major complications. The present project, based on the db/db mice as animal model, investigates the repercussions of diabetes mellitus in the transcriptome as well as the mechanism of action of pirfenidone, an antifibrotic drug, in the treatment of diabetic nephropathy. The study was centered on the system-wide measurements transcriptional state of the mouse kidney. The expression profile of three experimental groups: control, diabetic, and diabetic treated with the drug, were analyzed using expression clustering, gene ontology enrichment analysis, protein-protein interaction network mapping, and gene expression behavior. The results show significant expression dysregulation of genes involved in RNA processing, fatty acid oxidation, and oxidative phosphorylation under the diabetic condition. The drug is able to regulate the expression levels of RNA processing genes but it does not show any effect in the expression profile of genes required in the oxidative phosphorylation and in the fatty acid metabolism. In conclusion diabetes mellitus induce the dysregulation of the splicing apparatus, the oxidative phosphorylation, and the fatty acid metabolic pathway at an expression level. The malfunction of these biological pathways causes cellular stress by increasing the concentration of reactive oxygen species within the cell due to a high oxidative and respiratory activity of mitochondria in addition to the increased demand of the folding machinery as a consequence of a dysregulation of the splicing apparatus. Pirfenidone regulates the expression of RNA processing genes mainly

  13. Genome-wide selection signatures in Pinzgau cattle

    Directory of Open Access Journals (Sweden)

    Radovan Kasarda

    2015-08-01

    Full Text Available The aim of this study was to identify the evidence of recent selection based on estimation of the integrated Haplotype Score (iHS, population differentiation index (FST and characterize affected regions near QTL associated with traits under strong selection in Pinzgau cattle. In total 21 Austrian and 19 Slovak purebreed bulls genotyped with Illumina bovineHD and  bovineSNP50 BeadChip were used to identify genomic regions under selection. Only autosomal loci with call rate higher than 90%, minor allele frequency higher than 0.01 and Hardy-Weinberg equlibrium limit of 0.001 were included in the subsequent analyses of selection sweeps presence. The final dataset was consisted from 30538 SNPs with 81.86 kb average adjacent SNPs spacing. The iHS score were averaged into non-overlapping 500 kb segments across the genome. The FST values were also plotted against genome position based on sliding windows approach and averaged over 8 consecutive SNPs. Based on integrated Haplotype Score evaluation only 7 regions with iHS score higher than 1.7 was found. The average iHS score observed for each adjacent syntenic regions indicated slight effect of recent selection in analysed group of Pinzgau bulls. The level of genetic differentiation between Austrian and Slovak bulls estimated based on FST index was low. Only 24% of FST values calculated for each SNP was greather than 0.01. By using sliding windows approach was found that 5% of analysed windows had higher value than 0.01. Our results indicated use of similar selection scheme in breeding programs of Slovak and Austrian Pinzgau bulls. The evidence for genome-wide association between signatures of selection and regions affecting complex traits such as milk production was insignificant, because the loci in segments identified as affected by selection were very distant from each other. Identification of genomic regions that may be under pressure of selection for phenotypic traits to better understanding of the

  14. WISH: Wide-field Imaging Durvayor for High-redshift

    Science.gov (United States)

    Yamada, Toru

    2015-08-01

    We introduce the concept and current status of WISH project and discuss the science cases. WISH is a proposed space science mission for JAXA, which is dedicated for the deep and wide-field near-infrared imaging surveys. The mission contains the 1.5m cooled telescope as well as the imager with the FoV of ~850 square arcmin. The main goal of WISH is to detect and study galaxies at z=8-15 in the earliest history of structure formation in the universe. The key feature is to conduct WISH Ultra Deep Survey, which images in total of 100 square degrees in 6 broad-band filters at 0.9-4.5 micron down to 28AB magnitude. While more than 10^5 galaxies at z=8-9, 10^4 galaxies at z=11-12 will be detected, WISH-UDS is designed to constrain UV luminosity function at z=15. Depending on the models of the earliest evolution history, 1-1000 galaxies at z~15 (~100 galaxies for the moderate cases) will be detected. The UV spectral properties as well as the clustering properties of galaxies at z=8-15 can be studied as well; UV slope can be measured up to z=15, and the stellar and dark-matter-halo masses can be obtained up to z=9. WISH UDS can provide excellent opportunities for studying SNe at high redshift. Up to ~7000 type Ia SNe at z>1 can be detected and the distance modulus can be constrained with the precision of 0.9-1.5% at z>1.5. More than 100 Super Luminous SNe at z>6, and 10 SLSN at z>10 can also be detected, which allow us to study the earliest history of massive star formation in the universe. WISH imaging surveys as well as WISHSpec, which is an optional parallel-operation simple IFU spectrograph, also provide unique opportunities in various astronomical fields. WISH mission proposal was submitted to JAXA in February 2015 for the first down selection of JAXA Large Strategic Science Mission targeting the launch date in 2020-22. International collaborations including SAO (G.Fazio et al.), LAM (D. Burgarella et al.) and Canada (M.Sawicki et al.) are also actively coordinated.

  15. Genome-wide identification of significant aberrations in cancer genome.

    Science.gov (United States)

    Yuan, Xiguo; Yu, Guoqiang; Hou, Xuchu; Shih, Ie-Ming; Clarke, Robert; Zhang, Junying; Hoffman, Eric P; Wang, Roger R; Zhang, Zhen; Wang, Yue

    2012-07-27

    Somatic Copy Number Alterations (CNAs) in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus events from random background aberrations. Here we introduce Significant Aberration in Cancer (SAIC), a new method for characterizing and assessing the statistical significance of recurrent CNA units. Three main features of SAIC include: (1) exploiting the intrinsic correlation among consecutive probes to assign a score to each CNA unit instead of single probes; (2) performing permutations on CNA units that preserve correlations inherent in the copy number data; and (3) iteratively detecting Significant Copy Number Aberrations (SCAs) and estimating an unbiased null distribution by applying an SCA-exclusive permutation scheme. We test and compare the performance of SAIC against four peer methods (GISTIC, STAC, KC-SMART, CMDS) on a large number of simulation datasets. Experimental results show that SAIC outperforms peer methods in terms of larger area under the Receiver Operating Characteristics curve and increased detection power. We then apply SAIC to analyze structural genomic aberrations acquired in four real cancer genome-wide copy number data sets (ovarian cancer, metastatic prostate cancer, lung adenocarcinoma, glioblastoma). When compared with previously reported results, SAIC successfully identifies most SCAs known to be of biological significance and associated with oncogenes (e.g., KRAS, CCNE1, and MYC) or tumor suppressor genes (e.g., CDKN2A/B). Furthermore, SAIC identifies a number of novel SCAs in these copy number data that encompass tumor related genes and may warrant further studies. Supported by a well-grounded theoretical framework, SAIC has been developed and used to identify SCAs in various cancer copy number data sets, providing useful information to study the landscape of cancer genomes. Open-source and platform-independent SAIC software is

  16. Genome-wide identification of significant aberrations in cancer genome

    Directory of Open Access Journals (Sweden)

    Yuan Xiguo

    2012-07-01

    Full Text Available Abstract Background Somatic Copy Number Alterations (CNAs in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus events from random background aberrations. Here we introduce Significant Aberration in Cancer (SAIC, a new method for characterizing and assessing the statistical significance of recurrent CNA units. Three main features of SAIC include: (1 exploiting the intrinsic correlation among consecutive probes to assign a score to each CNA unit instead of single probes; (2 performing permutations on CNA units that preserve correlations inherent in the copy number data; and (3 iteratively detecting Significant Copy Number Aberrations (SCAs and estimating an unbiased null distribution by applying an SCA-exclusive permutation scheme. Results We test and compare the performance of SAIC against four peer methods (GISTIC, STAC, KC-SMART, CMDS on a large number of simulation datasets. Experimental results show that SAIC outperforms peer methods in terms of larger area under the Receiver Operating Characteristics curve and increased detection power. We then apply SAIC to analyze structural genomic aberrations acquired in four real cancer genome-wide copy number data sets (ovarian cancer, metastatic prostate cancer, lung adenocarcinoma, glioblastoma. When compared with previously reported results, SAIC successfully identifies most SCAs known to be of biological significance and associated with oncogenes (e.g., KRAS, CCNE1, and MYC or tumor suppressor genes (e.g., CDKN2A/B. Furthermore, SAIC identifies a number of novel SCAs in these copy number data that encompass tumor related genes and may warrant further studies. Conclusions Supported by a well-grounded theoretical framework, SAIC has been developed and used to identify SCAs in various cancer copy number data sets, providing useful information to study the landscape of cancer genomes

  17. Stability criteria for wide binary stars harboring Oort Clouds

    Science.gov (United States)

    Calandra, M. F.; Correa-Otto, J. A.; Gil-Hutton, R. A.

    2018-03-01

    Context. In recent years, several numerical studies have been done in the field of the stability limit. Although, many of them included the analysis of asteroids or planets, is not possible to find in the literature any work on how the presence of a binary star could affect other possible configurations in a three-body problem. In order to develop this subject we consider other structures like Oort Clouds in wide binary systems. Regarding the existence of Oort Clouds in extrasolar systems there are recent works that do not reject its possible existence. Aim. The aim of this work is to obtain the stability limit for Oort Cloud objects considering different masses of the secondary star and zero and non-zero inclinations of the particles. We improve our numerical treatment getting a mathematical fit that allows us to find the limit and compare our results with other previous works in the field. Methods: We use a symplectic integrator to integrate binary systems where the primary star is m1 = 1 M⊙ and the secondary, m2, takes 0.25 M⊙ and 0.66 M⊙ in two sets of simulations S1 and S2. The orbital parameters of the secondary star were varied in order to study different scenarios. We also used two different integration times (one shorter than the other) and included the presence of 1000 to 10 000 massless particles in circular orbits to form the Oort Cloud. The particles were disposed in four different inclination planes to investigate how the presence of the binary companion could affect the stability limit. Results: Using the Maximum Eccentricity Method, emax, together with the critical semimajor axis acrit we found that the emax criteria could reduce the integration times to find the limit. For those cases where the particles were in inclined orbits we found that there are particle groups that survive the integration time with a high eccentricity. These particle groups are found for our two sets of simulations, meaning that they are independent of the secondary

  18. World-Wide Web Tools for Locating Planetary Images

    Science.gov (United States)

    Kanefsky, Bob; Deiss, Ron (Technical Monitor)

    1995-01-01

    The explosive growth of the World-Wide Web (WWW) in the past year has made it feasible to provide interactive graphical tools to assist scientists in locating planetary images. The highest available resolution images of any site of interest can be quickly found on a map or plot, and, if online, displayed immediately on nearly any computer equipped with a color screen, an Internet connection, and any of the free WWW browsers. The same tools may also be of interest to educators, students, and the general public. Image finding tools have been implemented covering most of the solar system: Earth, Mars, and the moons and planets imaged by Voyager. The Mars image-finder, which plots the footprints of all the high-resolution Viking Orbiter images and can be used to display any that are available online, also contains a complete scrollable atlas and hypertext gazetteer to help locating areas. The Earth image-finder is linked to thousands of Shuttle images stored at NASA/JSC, and displays them as red dots on a globe. The Voyager image-finder plots images as dots, by longitude and apparent target size, linked to online images. The locator (URL) for the top-level page is http: //ic-www.arc.nasa.gov/ic/projects/bayes-group/Atlas/. Through the efforts of the Planetary Data System and other organizations, hundreds of thousands of planetary images are now available on CD-ROM, and many of these have been made available on the WWW. However, locating images of a desired site is still problematic, in practice. For example, many scientists studying Mars use digital image maps, which are one third the resolution of Viking Orbiter survey images. When they douse Viking Orbiter images, they often work with photographically printed hardcopies, which lack the flexibility of digital images: magnification, contrast stretching, and other basic image-processing techniques offered by off-the-shelf software. From the perspective of someone working on an experimental image processing technique for

  19. Wide-Field Optic for Autonomous Acquisition of Laser Link

    Science.gov (United States)

    Page, Norman A.; Charles, Jeffrey R.; Biswas, Abhijit

    2011-01-01

    An innovation reported in Two-Camera Acquisition and Tracking of a Flying Target, NASA Tech Briefs, Vol. 32, No. 8 (August 2008), p. 20, used a commercial fish-eye lens and an electronic imaging camera for initially locating objects with subsequent handover to an actuated narrow-field camera. But this operated against a dark-sky background. An improved solution involves an optical design based on custom optical components for the wide-field optical system that directly addresses the key limitations in acquiring a laser signal from a moving source such as an aircraft or a spacecraft. The first challenge was to increase the light collection entrance aperture diameter, which was approximately 1 mm in the first prototype. The new design presented here increases this entrance aperture diameter to 4.2 mm, which is equivalent to a more than 16 times larger collection area. One of the trades made in realizing this improvement was to restrict the field-of-view to +80 deg. elevation and 360 azimuth. This trade stems from practical considerations where laser beam propagation over the excessively high air mass, which is in the line of sight (LOS) at low elevation angles, results in vulnerability to severe atmospheric turbulence and attenuation. An additional benefit of the new design is that the large entrance aperture is maintained even at large off-axis angles when the optic is pointed at zenith. The second critical limitation for implementing spectral filtering in the design was tackled by collimating the light prior to focusing it onto the focal plane. This allows the placement of the narrow spectral filter in the collimated portion of the beam. For the narrow band spectral filter to function properly, it is necessary to adequately control the range of incident angles at which received light intercepts the filter. When this angle is restricted via collimation, narrower spectral filtering can be implemented. The collimated beam (and the filter) must be relatively large to

  20. Rotorcraft Aeromechanics Branch Home Page on the World Wide Web

    Science.gov (United States)

    Peterson, Randall L.; Warmbrodt, William (Technical Monitor)

    1996-01-01

    The tilt rotor aircraft holds great promise for improving air travel in the future. It's benefits include vertical take off and landing combined with airspeeds comparable to propeller driven aircraft. However, the noise from a tilt rotor during approach to a landing is potentially a significant barrier to widespread acceptance of these aircraft. This approach noise is primarily caused by Blade Vortex Interactions (BVI), which are created when the blade passes near or through the vortex trailed by preceding blades. The XV- 15 Aeroacoustic test will measure the noise from a tilt rotor during descent conditions and demonstrate several possible techniques to reduce the noise. The XV- 15 Aeroacoustic test at NASA Ames Research Center will measure acoustics and performance for a full-scale XV-15 rotor. A single XV-15 rotor will be mounted on the Ames Rotor Test Apparatus (RTA) in the 80- by 120-Foot Wind Tunnel. The test will be conducted in helicopter mode with forward flight speeds up to 100 knots and tip path plane angles up to +/- 15 degrees. These operating conditions correspond to a wide range of tilt rotor descent and transition to forward flight cases. Rotor performance measurements will be made with the RTA rotor balance, while acoustic measurements will be made using an acoustic traverse and four fixed microphones. The acoustic traverse will provide limited directionality measurements on the advancing side of the rotor, where BVI noise is expected to be the highest. Baseline acoustics and performance measurements for the three-bladed rotor will be obtained over the entire test envelope. Acoustic measurements will also be obtained for correlation with the XV-15 aircraft Inflight Rotor Aeroacoustic Program (IRAP) recently conducted by Ames. Several techniques will be studied in an attempt to reduce the highest measured BVI noise conditions. The first of these techniques will use sub-wings mounted on the blade tips. These subwings are expected to alter the size

  1. World-Wide Effort Produces Dramatic "Movie" of Cosmic Jet

    Science.gov (United States)

    2001-05-01

    Astronomers using a world-wide collection of radio telescopes, including the National Science Foundation's Very Long Baseline Array (VLBA) of the National Radio Astronomy Observatory (NRAO), have made a dramatic "movie" of a voracious, superdense neutron star repeatedly spitting out subatomic particles at nearly the speed of light into two narrow jets as it pulls material from a companion star. The movie shows these jets ejecting clouds of hot plasma that are then "zapped" by pulses of energy in the jets as they move away from the neutron star. Frame from Radio-Telescope 'Movie' of Scorpius X-1 "We have directly measured the speed of energy flow in a cosmic jet for the first time," said Ed Fomalont, an astronomer at the NRAO in Charlottesville, Virginia. Fomalont worked with Barry Geldzahler and Charles Bradshaw of George Mason University in Fairfax, Virginia. The astronomers used the VLBA, the NSF's Very Large Array (VLA) and the Green Bank 140-foot telescope, along with radio telescopes from the European VLBI Network, Australia, Japan and South Africa to record the double-star system's eruptions continuously for 56 hours. "This study is going to be extremely valuable in helping us understand a phenomenon that we see throughout the universe," Fomalont said. Cosmic jets of superfast particles are ejected from the cores of numerous galaxies. On a smaller scale, similar jets are ejected from binary-star systems closer to home, in our own Milky Way Galaxy. While the jets from galaxy cores are thought to be powered by supermassive black holes millions of times more massive than the Sun, the closer "microquasars" are powered by much smaller black holes or by neutron stars only a few times more massive than the sun. "Studying one of the closer, smaller examples will help us understand how they all work, including the bigger ones," Geldzahler said. "The jets coming from distant galaxies are harder to study because of their much greater distance and the slowness of their

  2. 76 FR 46854 - Hewlett Packard Company, Imaging and Printing Group, World Wide Product Data Management...

    Science.gov (United States)

    2011-08-03

    ..., Imaging and Printing Group, World Wide Product Data Management Operations, Including On-Site Leased... Company, Imaging and Printing Group, World Wide Products Data Management Operations, Boise, Idaho and Fort... of Hewlett Packard Company, Imaging and Printing Group, World Wide Product Data Management Operations...

  3. Wide area stability analysis and control of interconnected power systems with HVDC and FACTS devices

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yong

    2012-11-01

    In order to damp low-frequency oscillations and improve the overall stability of large-scale interconnected power systems, this book investigates the wide-area stability analysis and control methods from different perspectives. The flexible and fast control capability of high-voltage (FACTS) is investigated in detail to implement a wide-area measurement based damping control. A sequential and global mixed optimization method is proposed to simultaneously optimize local and wide area damping controllers. A wide-area robust coordination method is presented to coordinate multiple wide-area damping controllers (WADC). A delay-dependent robust design method is also proposed to handle time-varying delays commonly existing in wide-area signal communication. A closed-loop hardware experiment is used to validate the damping performance. The research activities of this book include power system stability analysis and control, wide-area damping control as well as HVDC and FACTS technologies.

  4. Evaluation of the uniformity of wide circular reference source and application of correction factors

    International Nuclear Information System (INIS)

    Silva Junior, I.A.; Xavier, M.; Siqueira, P.T.D.; Sordi, G.A.A.; Potiens, M.P.A.

    2017-01-01

    In this work the uniformity of wide circular reference sources is evaluated. This kind of reference source is still widely used in Brazil. In previous works wide rectangular reference sources were analyzed and it was shown the importance of the application of correction factors in calibration procedures of radiation monitors. Now a transposition of the methods used formerly is performed, evaluating the uniformities of circular reference sources and calculating the associated correction factors. (author)

  5. Fault Identification Algorithm Based on Zone-Division Wide Area Protection System

    OpenAIRE

    Xiaojun Liu; Youcheng Wang; Hub Hu

    2014-01-01

    As the power grid becomes more magnified and complicated, wide-area protection system in the practical engineering application is more and more restricted by the communication level. Based on the concept of limitedness of wide-area protection system, the grid with complex structure is divided orderly in this paper, and fault identification and protection action are executed in each divided zone to reduce the pressure of the communication system. In protection zone, a new wide-area...

  6. Application and development of non contact angle-wide viewing system in vitreous retinal surgery

    Directory of Open Access Journals (Sweden)

    Rong-Hua He

    2016-07-01

    Full Text Available Wide-angle viewing system as an important auxiliary device can clearly observe the whole fundus field of vision in vitreous surgery, which enable vitreoretinal surgery more efficient, safer and more effective. So it has very high application value in ophthalmologic operation. In this paper, we studied the development and application of wide-angle viewing system in vitreoretinal surgery in recent years, from which we summed up the advantage of non-contact wide-angle viewing system in clinical field, and pointed out the shortcomings. The ultimate goal is to make the non-contact wide-angle viewing system better applied in vitreous surgery.

  7. Graded index and randomly oriented core-shell silicon nanowires for broadband and wide angle antireflection

    Directory of Open Access Journals (Sweden)

    P. Pignalosa

    2011-09-01

    Full Text Available Antireflection with broadband and wide angle properties is important for a wide range of applications on photovoltaic cells and display. The SiOx shell layer provides a natural antireflection from air to the Si core absorption layer. In this work, we have demonstrated the random core-shell silicon nanowires with both broadband (from 400nm to 900nm and wide angle (from normal incidence to 60º antireflection characteristics within AM1.5 solar spectrum. The graded index structure from the randomly oriented core-shell (Air/SiOx/Si nanowires may provide a potential avenue to realize a broadband and wide angle antireflection layer.

  8. Wide applicability of high-Tc pairing originating from coexisting wide and incipient narrow bands in quasi-one-dimensional systems

    Science.gov (United States)

    Matsumoto, Karin; Ogura, Daisuke; Kuroki, Kazuhiko

    2018-01-01

    We study superconductivity in the Hubbard model on various quasi-one-dimensional lattices with coexisting wide and narrow bands originating from multiple sites within a unit cell, where each site corresponds to a single orbital. The systems studied are the two-leg and three-leg ladders, the diamond chain, and the crisscross ladder. These one-dimensional lattices are weakly coupled to form two-dimensional (quasi-one-dimensional) ones, and the fluctuation exchange approximation is adopted to study spin-fluctuation-mediated superconductivity. When one of the bands is perfectly flat and the Fermi level intersecting the wide band is placed in the vicinity of, but not within, the flat band, superconductivity arising from the interband scattering processes is found to be strongly enhanced owing to the combination of the light electron mass of the wide band and the strong pairing interaction due to the large density of states of the flat band. Even when the narrow band has finite bandwidth, the pairing mechanism still works since the edge of the narrow band, due to its large density of states, plays the role of the flat band. The results indicate the wide applicability of the high-Tc pairing mechanism due to coexisting wide and "incipient" narrow bands in quasi-one-dimensional systems.

  9. Quality control and conduct of genome-wide association meta-analyses

    DEFF Research Database (Denmark)

    Winkler, Thomas W; Day, Felix R; Croteau-Chonka, Damien C

    2014-01-01

    Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC...

  10. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

    NARCIS (Netherlands)

    Cornelis, M. C.; Byrne, E. M.; Esko, T.; Nalls, M. A.; Ganna, A.; Paynter, N.; Monda, K. L.; Amin, N.; Fischer, K.; Renstrom, F.; Ngwa, J. S.; Huikari, V.; Cavadino, A.; Nolte, I. M.; Teumer, A.; Yu, K.; Marques-Vidal, P.; Rawal, R.; Manichaikul, A.; Wojczynski, M. K.; Vink, J. M.; Zhao, J. H.; Burlutsky, G.; Lahti, J.; Mikkilä, V.; Lemaitre, R. N.; Eriksson, J.; Musani, S. K.; Tanaka, T.; Geller, F.; Luan, J.; Hui, J.; Mägi, R.; Dimitriou, M.; Garcia, M. E.; Ho, W.-K.; Wright, M. J.; Rose, L. M.; Magnusson, P. K. E.; Pedersen, N. L.; Couper, D.; Oostra, B. A.; Hofman, A.; Ikram, M. A.; Tiemeier, H. W.; Uitterlinden, A. G.; van Rooij, F. J. A.; Barroso, I.; Johansson, I.; Xue, L.; Kaakinen, M.; Milani, L.; Power, C.; Snieder, H.; Stolk, R. P.; Baumeister, S. E.; Biffar, R.; Gu, F.; Bastardot, F.; Kutalik, Z.; Jacobs, D. R.; Forouhi, N. G.; Mihailov, E.; Lind, L.; Lindgren, C.; Michaëlsson, K.; Morris, A.; Jensen, M.; Khaw, K.-T.; Luben, R. N.; Wang, J. J.; Männistö, S.; Perälä, M.-M.; Kähönen, M.; Lehtimäki, T.; Viikari, J.; Mozaffarian, D.; Mukamal, K.; Psaty, B. M.; Döring, A.; Heath, A. C.; Montgomery, G. W.; Dahmen, N.; Carithers, T.; Tucker, K. L.; Ferrucci, L.; Boyd, H. A.; Melbye, M.; Treur, J. L.; Mellström, D.; Hottenga, J. J.; Prokopenko, I.; Tönjes, A.; Deloukas, P.; Kanoni, S.; Lorentzon, M.; Houston, D. K.; Liu, Y.; Danesh, J.; Rasheed, A.; Mason, M. A.; Zonderman, A. B.; Franke, L.; Kristal, B. S.; Karjalainen, J.; Reed, D. R.; Westra, H.-J.; Evans, M. K.; Saleheen, D.; Harris, T. B.; Dedoussis, G.; Curhan, G.; Stumvoll, M.; Beilby, J.; Pasquale, L. R.; Feenstra, B.; Bandinelli, S.; Ordovas, J. M.; Chan, A. T.; Peters, U.; Ohlsson, C.; Gieger, C.; Martin, N. G.; Waldenberger, M.; Siscovick, D. S.; Raitakari, O.; Eriksson, J. G.; Mitchell, P.; Hunter, D. J.; Kraft, P.; Rimm, E. B.; Boomsma, D. I.; Borecki, I. B.; Loos, R. J. F.; Wareham, N. J.; Vollenweider, P.; Caporaso, N.; Grabe, H. J.; Neuhouser, M. L.; Wolffenbuttel, B. H. R.; Hu, F. B.; Hyppönen, E.; Järvelin, M.-R.; Cupples, L. A.; Franks, P. W.; Ridker, P. M.; van Duijn, C. M.; Heiss, G.; Metspalu, A.; North, K. E.; Ingelsson, E.; Nettleton, J. A.; van Dam, R. M.; Chasman, D. I.; Nalls, Michael A.; Plagnol, Vincent; Hernandez, Dena G.; Sharma, Manu; Sheerin, Una-Marie; Saad, Mohamad; Simón-Sánchez, Javier; Schulte, Claudia; Lesage, Suzanne; Sveinbjörnsdóttir, Sigurlaug; Arepalli, Sampath; Barker, Roger; Ben-Shlomo, Yoav; Berendse, Henk W.; Berg, Daniela; Bhatia, Kailash; de Bie, Rob M. A.; Biffi, Alessandro; Bloem, Bas; Bochdanovits, Zoltan; Bonin, Michael; Bras, M.; Brockmann, Kathrin; Brooks, Janet; Burn, David J.; Charlesworth, Gavin; Chen, Honglei; Chinnery, Patrick F.; Chong, Sean; Clarke, Carl E.; Cookson, Mark R.; Cooper, J. Mark; Corvol, Jean Christophe; Counsell, Carl; Damier, Philippe; Dartigues, Jean-François; Deloukas, Panos; Deuschl, Günther; Dexter, David T.; van Dijk, Karin D.; Dillman, Allissa; Durif, Frank; Dürr, Alexandra; Edkins, Sarah; Evans, Jonathan R.; Foltynie, Thomas; Dong, Jing; Gardner, Michelle; Gibbs, J. Raphael; Goate, Alison; Gray, Emma; Guerreiro, Rita; Harris, Clare; van Hilten, Jacobus J.; Hofman, Albert; Hollenbeck, Albert; Holton, Janice; Hu, Michele; Huang, Xuemei; Hershey, Milton S.; Wurster, Isabel; Mätzler, Walter; Hudson, Gavin; Hunt, Sarah E.; Huttenlocher, Johanna; Illig, Thomas; München, Helmholtz Zentrum; Jónsson, Pálmi V.; Lambert, Jean-Charles; Langford, Cordelia; Lees, Andrew; Lichtner, Peter; Limousin, Patricia; Lopez, Grisel; Lorenz, Delia; McNeill, Alisdair; Moorby, Catriona; Moore, Matthew; Morris, Huw R.; Morrison, Karen E.; O' Sullivan, Sean S.; Pearson, Justin; Perlmutter, Joel S.; Pétursson, Hjörvar; Pollak, Pierre; Potter, Simon; Ravina, Bernard; Revesz, Tamas; Riess, Olaf; Rivadeneira, Fernando; Rizzu, Patrizia; Ryten, Mina; Sawcer, Stephen; Schapira, Anthony; Scheffer, Hans; Shaw, Karen; Sidransky, Ellen; Smith, Colin; Spencer, Chris C. A.; Stefánsson, Hreinn; Bettella, Francesco; Stockton, Joanna D.; Strange, Amy; Talbot, Kevin; Tanner, M.; Tashakkori-Ghanbaria, Avazeh; Tison, François; Trabzuni, Daniah; Traynor, Bryan J.; Uitterlinden, André G.; Velseboer, Daan; Vidailhet, Marie; Walker, Robert; van de Warrenburg, Bart; Wickremaratchi, Mirdhu; Williams, Nigel; Williams-Gray, Caroline H.; Winder-Rhodes, Sophie; Stefánsson, Kári; Martinez, Maria; Sabatier, Paul; Wood, Nicholas W.; Hardy, John; Heutink, Peter; Brice, Alexis; Gasser, Thomas; Singleton, Andrew B.; Singleton, Andrew; Cookson, Mark; Hernandez, Dena; Nalls, Michael; Zonderman, Alan; Ferrucci, Luigi; Johnson, Robert; Longo, Dan; O'Brien, Richard; Traynor, Bryan; Troncoso, Juan; van der Brug, Marcel; Zielke, Ronald; Weale, Michael; Ramasamy, Adaikalavan; Box, P. O.

    2015-01-01

    Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to

  11. Genome-wide screening and identification of antigens for rickettsial vaccine development

    Science.gov (United States)

    The capacity to identify immunogens for vaccine development by genome-wide screening has been markedly enhanced by the availability of complete microbial genome sequences coupled to rapid proteomic and bioinformatic analysis. Critical to this genome-wide screening is in vivo testing in the context o...

  12. Building and Maintaining an Effective Campus-Wide Coalition for Suicide Prevention

    Science.gov (United States)

    Kaslow, Nadine J.; Garcia-Williams, Amanda; Moffitt, Lauren; McLeod, Mark; Zesiger, Heather; Ammirati, Rachel; Berg, John P.; McIntosh, Belinda J.

    2012-01-01

    Preventing suicide is a commonly shared priority among college administrators, faculty, staff, students, and family members. Coalitions are popular health promotion mechanisms for solving community-wide problems and are valuable in campus-wide suicide prevention efforts. This article provides an example of an effective suicide prevention…

  13. 75 FR 9277 - Proposed Information Collection (Nation-Wide Customer Satisfaction Surveys) Activity: Comment...

    Science.gov (United States)

    2010-03-01

    ... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0712] Proposed Information Collection (Nation-Wide Customer Satisfaction Surveys) Activity: Comment Request AGENCY: Veterans Health Administration... use of other forms of information technology. Title: Nation-wide Customer Satisfaction Surveys, VA...

  14. 77 FR 64382 - Agency Information Collection (Nation-Wide Customer Satisfaction Surveys) Activities Under OMB...

    Science.gov (United States)

    2012-10-19

    ... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0712] Agency Information Collection (Nation-Wide Customer Satisfaction Surveys) Activities Under OMB Review AGENCY: Veterans Health Administration... ``OMB Control No. 2900-0712.'' SUPPLEMENTARY INFORMATION: Title: Nation-wide Customer Satisfaction...

  15. 77 FR 2349 - Proposed Information Collection (Nation-wide Customer Satisfaction Surveys) Activity: Comment...

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0712] Proposed Information Collection (Nation-wide Customer Satisfaction Surveys) Activity: Comment Request AGENCY: Veterans Health Administration... techniques or the use of other forms of information technology. Title: Nation-wide Customer Satisfaction...

  16. 75 FR 25320 - Agency Information Collection (Nation-wide Customer Satisfaction Surveys) Activities Under OMB...

    Science.gov (United States)

    2010-05-07

    ... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0712] Agency Information Collection (Nation-wide Customer Satisfaction Surveys) Activities Under OMB Review AGENCY: Veterans Health Administration... ``OMB Control No. 2900-0712.'' SUPPLEMENTARY INFORMATION: Title: Nation-wide Customer Satisfaction...

  17. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index

    DEFF Research Database (Denmark)

    Minster, Ryan L; Sanders, Jason L; Singh, Jatinder

    2015-01-01

    BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted...

  18. Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

    DEFF Research Database (Denmark)

    Sud, Amit; Thomsen, Hauke; Law, Philip J.

    2017-01-01

    Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 co...

  19. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

    NARCIS (Netherlands)

    Cornelis, M. C.; Byrne, E. M.; Esko, T.; Nalls, M. A.; Ganna, A.; Paynter, N.; Monda, K. L.; Amin, N.; Fischer, K.; Renstrom, F.; Ngwa, J. S.; Huikari, V.; Cavadino, A.; Nolte, I. M.; Teumer, A.; Yu, K.; Marques-Vidal, P.; Rawal, R.; Manichaikul, A.; Wojczynski, M. K.; Vink, J. M.; Zhao, J. H.; Burlutsky, G.; Lahti, J.; Mikkila, V.; Lemaitre, R. N.; Eriksson, J.; Musani, S. K.; Tanaka, T.; Geller, F.; Luan, J.; Hui, J.; Maegi, R.; Dimitriou, M.; Garcia, M. E.; Ho, W-K; Wright, M. J.; Rose, L. M.; Magnusson, P. K. E.; Pedersen, N. L.; Couper, D.; Oostra, B. A.; Hofman, A.; Ikram, M. A.; Tiemeier, H. W.; Uitterlinden, A. G.; van Rooij, F. J. A.; Barroso, I.; Johansson, I.; Xue, L.; Kaakinen, M.; Milani, L.; Power, C.; Snieder, H.; Stolk, R. P.; Baumeister, S. E.; Biffar, R.; Gu, F.; Bastardot, F.; Kutalik, Z.; Jacobs, D. R.; Forouhi, N. G.; Mihailov, E.; Lind, L.; Lindgren, C.; Michaelsson, K.; Morris, A.; Jensen, M.; Khaw, K-T; Luben, R. N.; Wang, J. J.; Mannisto, S.; Perala, M-M; Kahonen, M.; Lehtimaki, T.; Viikari, J.; Mozaffarian, D.; Mukamal, K.; Psaty, B. M.; Doering, A.; Heath, A. C.; Montgomery, G. W.; Dahmen, N.; Carithers, T.; Tucker, K. L.; Ferrucci, L.; Boyd, H. A.; Melbye, M.; Treur, J. L.; Mellstrom, D.; Hottenga, J. J.; Prokopenko, I.; Toenjes, A.; Deloukas, P.; Kanoni, S.; Lorentzon, M.; Houston, D. K.; Liu, Y.; Danesh, J.; Rasheed, A.; Mason, M. A.; Zonderman, A. B.; Franke, L.; Kristal, B. S.; Karjalainen, J.; Reed, D. R.; Westra, H-J; Evans, M. K.; Saleheen, D.; Harris, T. B.; Dedoussis, G.; Curhan, G.; Stumvoll, M.; Beilby, J.; Pasquale, L. R.; Feenstra, B.; Bandinelli, S.; Ordovas, J. M.; Chan, A. T.; Peters, U.; Ohlsson, C.; Gieger, C.; Martin, N. G.; Waldenberger, M.; Siscovick, D. S.; Raitakari, O.; Eriksson, J. G.; Mitchell, P.; Hunter, D. J.; Kraft, P.; Rimm, E. B.; Boomsma, D. I.; Borecki, I. B.; Loos, R. J. F.; Wareham, N. J.; Vollenweider, P.; Caporaso, N.; Grabe, H. J.; Neuhouser, M. L.; Wolffenbuttel, B. H. R.; Hu, F. B.; Hyppoenen, E.; Jarvelin, M-R; Cupples, L. A.; Franks, P. W.; Ridker, P. M.; van Duijn, C. M.; Heiss, G.; Metspalu, A.; North, K. E.; Ingelsson, E.; Nettleton, J. A.; van Dam, R. M.; Chasman, D. I.

    Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to

  20. Examining Barriers to Sustained Implementation of School-Wide Prevention Practices

    Science.gov (United States)

    Turri, Mary G.; Mercer, Sterett H.; McIntosh, Kent; Nese, Rhonda N. T.; Strickland-Cohen, M. Kathleen; Hoselton, Robert

    2016-01-01

    The purpose of this study was to determine if an experimental 5-item measure of barriers to implementing and sustaining school-wide prevention practices, the "Assessment of Barriers to Implementation and Sustainability in Schools" (ABISS), would relate to objective measures of school-wide positive behavioral interventions and supports…