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Sample records for wu zi yuan

  1. Nonlinear bias compensation of ZiYuan-3 satellite imagery with cubic splines

    Science.gov (United States)

    Cao, Jinshan; Fu, Jianhong; Yuan, Xiuxiao; Gong, Jianya

    2017-11-01

    Like many high-resolution satellites such as the ALOS, MOMS-2P, QuickBird, and ZiYuan1-02C satellites, the ZiYuan-3 satellite suffers from different levels of attitude oscillations. As a result of such oscillations, the rational polynomial coefficients (RPCs) obtained using a terrain-independent scenario often have nonlinear biases. In the sensor orientation of ZiYuan-3 imagery based on a rational function model (RFM), these nonlinear biases cannot be effectively compensated by an affine transformation. The sensor orientation accuracy is thereby worse than expected. In order to eliminate the influence of attitude oscillations on the RFM-based sensor orientation, a feasible nonlinear bias compensation approach for ZiYuan-3 imagery with cubic splines is proposed. In this approach, no actual ground control points (GCPs) are required to determine the cubic splines. First, the RPCs are calculated using a three-dimensional virtual control grid generated based on a physical sensor model. Second, one cubic spline is used to model the residual errors of the virtual control points in the row direction and another cubic spline is used to model the residual errors in the column direction. Then, the estimated cubic splines are used to compensate the nonlinear biases in the RPCs. Finally, the affine transformation parameters are used to compensate the residual biases in the RPCs. Three ZiYuan-3 images were tested. The experimental results showed that before the nonlinear bias compensation, the residual errors of the independent check points were nonlinearly biased. Even if the number of GCPs used to determine the affine transformation parameters was increased from 4 to 16, these nonlinear biases could not be effectively compensated. After the nonlinear bias compensation with the estimated cubic splines, the influence of the attitude oscillations could be eliminated. The RFM-based sensor orientation accuracies of the three ZiYuan-3 images reached 0.981 pixels, 0.890 pixels, and 1

  2. Temporal Courses in EEG Theta and Alpha Activity in the Dynamic Health Qigong Techniques Wu Qin Xi and Liu Zi Jue

    Directory of Open Access Journals (Sweden)

    Diana Henz

    2018-01-01

    Full Text Available Health Qigong is a common technique of Traditional Chinese Medicine applied to strengthen mental and physical health. Several studies report increases in EEG theta and alpha activity after meditative Qigong techniques indicating a relaxed state of mind. To date, little is known on the effects of dynamic Health Qigong techniques that comprise bodily movements on brain activity. In the current study, we compared effects of two dynamic Health Qigong techniques on EEG brain activity. Subjects performed the techniques Wu Qin Xi (five animals play and Liu Zi Jue (six healing sounds in a within-subjects design. Eyes-open and eyes-closed resting EEG was recorded before and immediately after each 15-min practice block. Additionally, the Profile of Mood States (POMS questionnaire was administered at pretest, and after each 15-min practice block. Results show a decrease in alpha activity after 15 min, followed by an increase after 30 min in the Health Qigong technique Liu Zi Jue. Theta activity was decreased after 15 min, followed by an increase after 30 min in the technique Wu Qin Xi. Results of the POMS indicated an increased vigor-activity level with decreased fatigue and tension-anxiety levels in both techniques after 30 min of practice. Our results demonstrate different temporal dynamics in EEG theta and alpha activity for the Health Qigong techniques Wu Qin Xi and Liu Zi Jue. We hypothesize that the found brain activation patterns result from different attentional focusing styles and breathing techniques performed during the investigated Health Qigong techniques.

  3. YUAN-BO SUN

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. YUAN-BO SUN. Articles written in Journal of Genetics. Volume 97 Issue 1 March 2018 pp 173-178 RESEARCH ARTICLE. Investigating multiple dysregulated pathways in rheumatoid arthritis based on pathway interaction network · XIAN-DONG SONG XIAN-XU SONG GUI-BO LIU ...

  4. Kong Zi on Good Governance

    Directory of Open Access Journals (Sweden)

    Moses Aaron T. Angeles

    2008-12-01

    Full Text Available This paper will delve into the problem of Good Governance in the light of Kong Zi. What makes up a Just State? What are the elements that constitute a prosperous Kingdom? What principles of Confucianism can we employ to achieve a just and humane society? These are the primary questions that we will try to investigate as we go along. The paper will be thus divided into three essential parts: The Notion of Li and the Sovereign, The ConfucianMoral Ideal, and lastly, The Great Commonwealth.

  5. [Research on the original plants of Xian Zhao Zi (Senshosi)].

    Science.gov (United States)

    Kotaka, Shuji

    2008-01-01

    Since the Heian period, Xian Zhao Zi (Senshosi) has been used as part of the ceremony believed to help in a healthy pregnancy and safe birth. The purpose of this report is to consider which plants are original Xian Zhao Zi plants. Past research lists certain plants as Xian Zhao Zi, but it was difficult to draw any conclusions.

  6. Obituary: Chi Yuan (1937-2008)

    Science.gov (United States)

    Ho, Paul

    2011-12-01

    Chi Yuan graduated from the National Taiwan University in1959, and received his Masters of Science degree from the University of Florida in 1962, and his Doctor of Philosophy from the University of Michigan in 1966. He was a postdoctoral fellow with Professor C.C. Lin at MIT for three years, before taking his faculty post at the City College of New York in 1969. He attained full professorship at CCNY in 1981. From 1994-1996, Chi returned to Taiwan as Director of the newly found Academia Sinica Institute of Astronomy and Astrophysics (ASIAA). From 1997-2002, he was the recipient of an Outstanding Scholar Award, reserved for the most distinguished scientists employed in Taiwan. Chi retired from ASIAA in 2007, but continued to be active in his research during his two-year fight with brain cancer. Chi Yuan made his greatest impact with his work on the density-wave theory for spiral arm structures in galaxies, with C.C. Lin and Frank Shu. His early work elucidated the observational tests of density-wave theory, and the effects of magnetic fields in galactic shocks. In the 1980s, Chi Yuan worked on spiral density waves in Saturn's rings. In the past two decades, Chi Yuan concentrated on the problem of barred and spiral structures in the nuclei of galaxies, with their implications for fueling the central supermassive black holes. He also worked on the problem of the migration of giant extrasolar planets in their solar disks. These studies were made possible by his establishment of a program on computational fluid dynamics, which became one of the key initiatives in theory at the ASIAA. Among his academic records, two contributions are particularly notable. First, with Typhoon Lee, Fred Lo, and Frank Shu, Chi Yuan founded the ASIAA in order to stimulate the growth of astronomy in Taiwan. Second, and perhaps his greatest influence, has been his training and mentoring of a great number of students in astrophysics, especially for the last 20 years in Taiwan. Today, astronomy

  7. Wu Chien-Shiung: A brief biography

    Science.gov (United States)

    Chiang, Tsai-Chien

    2015-12-01

    My first encounter with professor Wu Chien-Shiung, a leading experimental physicist, 31 years ago inspired me to write her biography. I received much encouragement when planning this biography, especially from Dr. Yang Chen Ning, whose biography I wrote later. The real challenges in writing Wu's biography were finding the balance between both sides of her life and overcoming the obstacle that, unlike theoretical physicists (such as Yang), experimental physicists are inclined more to deeds than to words.

  8. [Professor WU Zhongchao's experience of penetration needling].

    Science.gov (United States)

    Zhang, Ning; Wang, Bing; Zhou, Yu

    2016-08-12

    Professor WU Zhongchao has unique application of penetration needling in clinical treatment. Professor WU applies penetration needling along meridians, and the methods of penetration needling include self-meridian penetration, exterior-interior meridian penetration, identical-name meridian penetration, different meridian penetration. The meridian differentiation is performed according to different TCM syndromes, locations and natures of diseases and acupoint nature, so as to make a comprehensive assessment. The qi movement during acupuncture is focused. In addition, attention is paid on anatomy and long-needle penetration; the sequence and direction of acupuncture is essential, and the reinforcing and reducing methods have great originality, presented with holding, waiting, pressing and vibrating. Based on classical acupoint, the acupoint of penetration needling is flexible, forming unique combination of acupoints.

  9. Liu Fang Yuan at The Huntington——An Overview

    Institute of Scientific and Technical Information of China (English)

    (USA)Laurie Sowd

    2009-01-01

    Liu Fang Yuan is a classical Chinese Garden, the Garden of Flowing Fragrance, a most remarkable project in Huntington. This project was conceived by James Folsom. It is an international business venture, complex construction project, unique China-US collaboration, and center of cultural memory. Inspired by the centuries-old Chinese tradition of private gardens, Liu Fang Yuan combines the scenic beauty of nature with the expressiveness of literature to give deeper meaning to the landscape. True to the authentic nature of a Chinese garden, the design respects the site. It extends to adapting some of the traditional elements of Chinese garden design to meet local needs for seismic safety and wheelchair accessibility. Liu Fang Yuan is the only truly seasonal garden at the Huntington, emphasizing and symbolizing the progression of winter, spring, summer, and autumn. The visitor experiences more than the visual realm. The garden's name, Liu Fang Yuan, has bolh literal and symbolic meanings refer to the scent of flowers and trees, also echoes the name of famed Ming dynasty painter Li Liufang. Liu Fang Yuan is truly a microcosm of The Huntington, bringing together botany, art and literature in a garden that will serve as a place of cultural memory and center for education about one of the great humanities traditions of the world.

  10. Lattice models and integrability: a special issue in honour of F Y Wu

    Science.gov (United States)

    Guttmann, A. J.; Jacobsen, J. L.

    2012-12-01

    Fa Yueh (Fred) Wu was born on 5 January 1932 in Nanking (now known as Nanjing), China, the capital of the Nationalist government. Wu began kindergarten in 1937 in a comfortable setting, as his father held a relatively high government position. But the Sino-Japanese war broke out in July 1937, and Nanking fell to Japanese hands in November. Fleeing the Japanese, his parents brought Wu to their hometown in Hunan, and then to the war capital Chungking (now Chongqing) in 1938, where they lived for eight years until the end of the war. Around that time the Japanese began bombing Chungking, and Wu's childhood memories were dominated by air raids, bombings and burning not dissimilar to those experienced by Londoners during the war. At times the air raids lasted for days disrupting everyday lives in Chungking, including Wu's schooling. One day during a fierce bombing raid, a bomb fell in their garden reducing a pavilion and the surrounding pond to a huge crater; another bomb fell just a few metres from the tunnel where his family took shelter, almost sealing the only entrance. The family moved the very next day to the countryside. As a result of the war, Wu attended seven schools before finishing his primary education. Fortunately, by the time he entered junior high school in 1943, the Japanese forces were on the wane and Wu entered the elite middle school, Nankai. His early academic performance in Nankai seemed to him mediocre, but he nevertheless impressed his geometry teacher by showing bursts of talent. With hindsight, this early interest in geometry may have led to his later insights in graphical analyses of statistical systems. The family returned to Nanking in 1946 after the Victory over Japan Day. By this time his father had become elected to the Legislative Yuan, the equivalent of the US Senate. Wu entered high school in Nanking in 1946. Since he came from an elite school in Chungking, he excelled in most of his classes, especially mathematics. Notwithstanding his

  11. Non-minimal Wu-Yang monopole

    International Nuclear Information System (INIS)

    Balakin, A.B.; Zayats, A.E.

    2007-01-01

    We discuss new exact spherically symmetric static solutions to non-minimally extended Einstein-Yang-Mills equations. The obtained solution to the Yang-Mills subsystem is interpreted as a non-minimal Wu-Yang monopole solution. We focus on the analysis of two classes of the exact solutions to the gravitational field equations. Solutions of the first class belong to the Reissner-Nordstroem type, i.e., they are characterized by horizons and by the singularity at the point of origin. The solutions of the second class are regular ones. The horizons and singularities of a new type, the non-minimal ones, are indicated

  12. Selection and Management of Medical Official during the Yuan Dynasty

    Directory of Open Access Journals (Sweden)

    Dae-Gi KIM

    2017-12-01

    Full Text Available Although the healthcare system of the Yuan Dynasty followed that of the Song Dynasty, there are certain differences between these two dynasties in terms of practices. Including appointing ‘Yihus’ in ‘Zhusehuji’ and setting up ‘Guanyitijusi’ to oversee Yihus, the Yuan Dynasty developed an effective management system for their physicians and, soon after the coronation of Khubilai, built ‘Yixue (Medical school’ all over its territories in order to establish an organized and substantial medical training system. Moreover, the Yuan Dynasty not only revived the civil service examination system system between 1314 and 1320 as well as the medical examination system, but also increased the quota for qualification to twice that of Confucian examination in Song. These changes resulted in producing many brilliant people at the time. In the second half of the reign of Emperor Chengzong it was decided that the incompetence of the government healthcare organizations and the abundance of charlatans could not be neglected any longer. Existing policies and systems was limited in educating and training proper physicians, and this problem was not restricted to the field of medicine. The need for new systems that could reform the social order led to the restoration of the civil service examination system. The civil service examination system for Confucianism and for medicine began in 1314 and 1316, respectively. The purpose of the medical examination system was to select medical officials. The medical examination system which started in 1316 had a significant impact on the medicine of the Yuan dynasty for many reasons. Firstly, the qualification to apply to the medical examination did not remain constricted to ‘Yixue’ but opened to all ‘Zhusehuji’; and secondly, the examination system did not have a restriction on the number of applicants was not restricted. The most important aspect of the examination system was that the number of test takers

  13. Selection and Management of Medical Official during the Yuan Dynasty.

    Science.gov (United States)

    Kim, Dae-Gi

    2017-12-01

    Although the healthcare system of the Yuan Dynasty followed that of the Song Dynasty, there are certain differences between these two dynasties in terms of practices. Including appointing 'Yihus' in 'Zhusehuji' and setting up 'Guanyitijusi' to oversee Yihus, the Yuan Dynasty developed an effective management system for their physicians and, soon after the coronation of Khubilai, built 'Yixue (Medical school)' all over its territories in order to establish an organized and substantial medical training system. Moreover, the Yuan Dynasty not only revived the civil service examination system system between 1314 and 1320 as well as the medical examination system, but also increased the quota for qualification to twice that of Confucian examination in Song. These changes resulted in producing many brilliant people at the time. In the second half of the reign of Emperor Chengzong it was decided that the incompetence of the government healthcare organizations and the abundance of charlatans could not be neglected any longer. Existing policies and systems was limited in educating and training proper physicians, and this problem was not restricted to the field of medicine. The need for new systems that could reform the social order led to the restoration of the civil service examination system. The civil service examination system for Confucianism and for medicine began in 1314 and 1316, respectively. The purpose of the medical examination system was to select medical officials. The medical examination system which started in 1316 had a significant impact on the medicine of the Yuan dynasty for many reasons. Firstly, the qualification to apply to the medical examination did not remain constricted to 'Yixue' but opened to all 'Zhusehuji'; and secondly, the examination system did not have a restriction on the number of applicants was not restricted. The most important aspect of the examination system was that the number of test takers that passed the first test was one hundred

  14. TL dating of vases with elephant ears in Yuan Dynasty

    International Nuclear Information System (INIS)

    Xia Junding; Wang Weida; Leung, P.L.

    2005-01-01

    Thermoluminescence (TL) dating using an activation method in pre-dose technique was described. Three vases in underglaze blue with elephant ears and one vase in underglaze red with elephant ears in Yuan Dynasty were dated by this method. The results show that the TL ages are all less than 100 a B.P., and in which sbc 648 and sbc 649 were imitated in recent years. This method is quick, convenient and reliable for porcelain dating with the age of less than 1000 a B.P.. As a comparison, a porcelain sample with underglaze blue in Yuan Dynasty was dated too, and its TL age is 620 ± 140 B.P.. In addition, some complex factors associated with dating have been discussed and a resolution has been raised, which will help improve the accuracy of TL dating. (authors)

  15. On soliton solutions of the Wu-Zhang system

    Directory of Open Access Journals (Sweden)

    Inc Mustafa

    2016-01-01

    Full Text Available In this paper, the extended tanh and hirota methods are used to construct soliton solutions for the WuZhang (WZ system. Singular solitary wave, periodic and multi soliton solutions of the WZ system are obtained.

  16. THE YUAN-TSEH LEE ARRAY FOR MICROWAVE BACKGROUND ANISOTROPY

    International Nuclear Information System (INIS)

    Ho, Paul T. P.; Altamirano, Pablo; Chang, C.-H.; Chang, S.-H.; Chang, S.-W.; Chen, C.-C.; Chen, K.-J.; Chen, M.-T.; Han, C.-C.; Ho, West M.; Huang, Y.-D.; Hwang, Y.-J.; Ibanez-Romano, Fabiola; Jiang Homin; Koch, Patrick M.; Kubo, Derek Y.; Li, C.-T.; Lim, Jeremy; Lin, K.-Y.; Liu, G.-C.

    2009-01-01

    The Yuan-Tseh Lee Array for microwave background anisotropy is the first interferometer dedicated to study the cosmic microwave background radiation at 3 mm wavelength. The choice of 3 mm is to minimize the contributions from foreground synchrotron radiation and Galactic dust emission. The initial configuration of seven 0.6 m telescopes mounted on a 6 m hexapod platform was dedicated in 2006 October on Mauna Loa, Hawaii. Scientific operations began with the detection of a number of clusters of galaxies via the thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak-lensing data to study the structure of dark matter. We also compare our data with X-ray data to derive the Hubble constant.

  17. [The essence of Professor Wu Lian-Zhong's acupuncture manipulation].

    Science.gov (United States)

    Liu, Jing; Guo, Yi; Wu, Lian-Zhong

    2014-05-01

    The painless needle insertion technique, summarized by Professor WU Lian-zhong during his decades of acupuncture clinical practice is introduced in this article, which is characterized as soft, flexible, fast, plucking and activating antipathogenic qi. The Sancai (three layers) lifting and thrusting manipulation technique is adopted by Professor WU for getting the qi sensation. And features of 10 kinds of needling sensation such as soreness, numbness, heaviness, distension, pain, cold, hot, radiation, jumping and contracture are summarized. Finger force, amplitude, speed and time length are also taken as the basis of reinforcing and reducing manipulations. Moreover, examples are also given to explain the needling technique on some specific points which further embodies Professor WU's unique experiences and understandings on acupuncture.

  18. Wu-Ling-San formula prophylaxis against recurrent calcium oxalate ...

    African Journals Online (AJOL)

    Wu-Ling-San (WLS) formula has been proved to prevent calcium oxalate nephrolithiasis both in vitro and in vivo. This is the first prospective, randomized and placebo-controlled clinical trial of WLS in calcium oxalate nephrolithiasis prevention. All patients who enrolled were asked to drink enough fluid to urinate at least 2 L ...

  19. Moessbauer study of the Ru porcelain of Chinese Song Dynasty and Yuan Dynasty

    International Nuclear Information System (INIS)

    Gao Zhengyao; Chen Xiande

    1994-01-01

    The Moessbauer spectra from the glazes of the Song Dynasty and the Yuan Dynasty Ru porcelains and the imitative ancient Ru porcelain are compared and analyzed. It is determined that the original firing atmosphere of the Yuan Dynasty Ru porcelain was reductive. The firing temperature was 1250 ± 20 C. The original firing atmosphere of the Song Dynasty Ru porcelain was also reductive; the firing temperature was above 1200 C. The coloring mechanism of these glazes is discussed. (orig.)

  20. Towards a Collective Intelligence: Transmediality and the Wu Ming Project

    Directory of Open Access Journals (Sweden)

    Melina Anne Masterson

    2014-11-01

    Full Text Available Dagli albori della Seconda Repubblica in Italia,  le strategie di dominio sui mass media dell’ex premier Silvio Berlusconi hanno avuto un effetto considerevole sull’immaginario culturale italiano. In un approccio multisensoriale e multimediale alla scrittura, il collettivo Wu Ming mette in questione i paradigmi culturali che negli ultimi venti anni sono diventati egemonici. L’esperienza di un romanzo dei Wu Ming va ben oltre la parola stampata poiché cerca di stimolare tutti i cinque sensi per arricchire il modo in cui il lettore vive quello che c’è sulla pagina, dimostrando esempi chiari della «convergence culture» coniata da Henry Jenkins. Questo saggio esamina l’interazione tra parola e immagine messa in atto dal collettivo tramite il sito Pinterest e illustra come questo aspetto del loro progetto rappresenti un microcosmo di un approccio complessivo alla creazione estetica e alla pratica culturale. Inoltre, questo saggio descrive in che modo il processo collettivo di consumo portato avanti dai Wu Ming contribuisca alla formazione delle «communities of sentiment» di Arjun Appadurai e alla «intelligenza collettiva» di Jenkins. Queste sono formazioni che rivitalizzano il concetto di cultura popolare per la nostra epoca digitale e offrono un’alternativa ad un immaginario culturale italiano sovra-determinato dalle pratiche del Berlusconismo.

  1. Combinatorial interpretation of Haldane-Wu fractional exclusion statistics.

    Science.gov (United States)

    Aringazin, A K; Mazhitov, M I

    2002-08-01

    Assuming that the maximal allowed number of identical particles in a state is an integer parameter, q, we derive the statistical weight and analyze the associated equation that defines the statistical distribution. The derived distribution covers Fermi-Dirac and Bose-Einstein ones in the particular cases q=1 and q--> infinity (n(i)/q-->1), respectively. We show that the derived statistical weight provides a natural combinatorial interpretation of Haldane-Wu fractional exclusion statistics, and present exact solutions of the distribution equation.

  2. Mössbauer study of the Ru porcelain of Chinese Song Dynasty and Yuan Dynasty

    Science.gov (United States)

    Zhengyao, Gao; Songhua, Chen; Xiande, Chen

    1994-12-01

    The Mössbauer spectra from the glazes of the Song Dynasty and the Yuan Dynasty Ru porcelains and the imitative ancient Ru porcelain are compared and analyzed. It is determined that the original firing atmosphere of the Yuan Dynasty Ru porcelain was reductive. The firing temperature was 1250±20 ‡C. The original firing atmosphere of the Song Dynasty Ru porcelain was also reductive; the firing temperature was above 1200 ‡C. The coloring mechanism of these glazes is discussed.

  3. Anhui Tongling Invests 1 Billion Yuan to Set up “Copper Industry Fund”

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>On September 12, the signing ceremony for "Anhui Copper Industry Fund" set up by Anhui Tongling Development & Investment Group Co., Ltd. and Shanghai V. Stone Investment Management Co., Ltd. was held in Tongling. The fund is 1 billion yuan.

  4. Professor Ta-You Wu and his ideas of science

    International Nuclear Information System (INIS)

    Ye Minghan; Dai Nianzu

    2005-01-01

    The career of Professor Ta-You Wu and his contributions in the latter half of his life in Taiwan, China are briefly reviewed. The authors focus our discussion on some of his ideas in pushing forward the advancement of science and technology in Taiwan and in promoting scientific standards. These ideas include: emphasis on the importance of basic science and qualified personnel as the foundation for the development of science and technology, and while advocating applied science he pointed out that 'future profits depend on high technology'. Thus, he contributed greatly to the rise of the economy in Taiwan. His view of the dispute between Bohr and Einstein is also briefly reviewed, as well as his principles of leadership as the president of Academia Sinica, Taiwan. (author)

  5. Effect of healthy Qigong “WuQinXi” exercise on peripheral blood T ...

    African Journals Online (AJOL)

    USER

    2010-07-19

    Jul 19, 2010 ... cell subgroups in elderly “WuQinXi” practitioners. Fifty healthy Chinese ... on health condition, diet, medical history, lifestyle and menstrual status, .... Mechanism of health-promotion of “WuQinXi” exercise created in East Hai ...

  6. We Can't Get No (Life) Satisfaction? Comment on Oswald and Wu (2010)

    Science.gov (United States)

    Pesta, Bryan J.; McDaniel, Michael A.; Bertsch, Sharon

    2010-01-01

    Oswald and Wu (2010; "Science") recently reported life satisfaction ranks for residents of the 50 U.S. states. Their rankings were framed as measures of "well-being," but were derived from responses to only a single survey item ("In general, how satisfied are you with your life?"). Here we contrast Oswald and Wu's subjective rankings with our…

  7. Research on Remote Sensing recognition features of Yuan Yang Terraces in Yunnan Province (China)

    Science.gov (United States)

    Xiang, Jie; Chen, Jianping; Lai, ZiLi; Yang, Wei

    2016-04-01

    Yuan Yang terraces is one of the most famous terraces in China, and it was successfully listed in the world heritage list at the 37th world heritage convention. On the one hand, Yuan Yang terraces retain more soil and water, to reduce both hydrological connectivity and erosion, and to support irrigation. On the other hand, It has the important tourism value, bring the huge revenue to local residents. In order to protect and make use of Yuan Yang terraces better, This study analyzed the spatial distribution and spectral characteristics of terraces:(1) Through visual interpretation, the study recognized the terraces based on the spatial adjusted remote sensing image (2010 Geoeye-1 with resolution of 1m/pix), and extracted topographic feature (elevation, slope, aspect, etc.) based on the digital elevation model with resolution of 20m/pix. The terraces cover a total area of about 11.58Km2, accounted for 24.4% of the whole study area. The terraces appear at range from 1400m to 1800m in elevation, 10°to 20°in slope, northwest to northeast in aspect; (2) Using the method of weight of evidence, this study assessed the importance of different topographic feature. The results show that the sort of importance: elevation>slope>aspect; (3) The study counted the Normalized Difference Vegetation Index (NDVI) changes of terraces throughout the year, based on the landsat-5 image with resolution of 30m/pix. The results show that the changes of terraces' NDVI are bigger than other stuff (e.g. forest, road, house, etc.). Those work made a good preparations for establishing the dynamic remote sensing monitoring system of Yuan Yang terraces.

  8. Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis

    Directory of Open Access Journals (Sweden)

    Xiangyang Yu

    2014-01-01

    Full Text Available Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction.

  9. Governing Civil Service Pay in China, by Alfred M. Wu. Copenhagen: NIAS Press, 2014. xvi+236 pp

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2016-01-01

    Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014.......Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014....

  10. Chien-Shiung Wu: An Icon of Physicist and Woman Scientist in China

    Science.gov (United States)

    Zhu, Yuelin

    2014-03-01

    Chien-Shiung Wu, the first female president of APS, is a well-known figure in China, a figure who serves as an inspiration for youths, especially young women, to study science and particularly physics. In this presentation, a historical perspective will be used to show how such an icon was formed. Born in 1912, the year of the Republic Revolution, Wu was in the first generation of physicists in China and her college mentor was a student of Marie Curie. When Wu came to the U.S. for graduate studies in the 1930s, it was a ``golden age'' for nuclear physics, and the invention of the cyclotron by E. O. Lawrence put UC Berkeley at the frontier. Wu was trained there, with Lawrence as her advisor, and later became an expert in Beta-decay. In 1956, Wu conceived and initiated the experiment of Cobalt-60, which, together with other two experiments, eventually proved the asymmetry of parity in weak-interactions, a hypothesis proposed by T. D. Lee and C. N. Yang. The importance of the experiment gained Wu an enormous reputation which spread even to China, when this was a period of hostility in Sino-American relations, and near total isolation due to the Cold-War. Wu was the daughter of a revolutionary, and an activist in college in patriotic student movements, and she combined this background with her scientific career as the way of ``Saving China with Science,'' a common belief reflecting the Zeitgeist of her time. Although she spent most of her life in the U.S., Wu never wavered in her love for or loyalty to her motherland. Her patriotism, as well as her scientific achievement, made Wu a legend in China, being called ``the Chinese Madam Curie.'' Even during the Cultural Revolution, a novel supposedly taking Wu as the original model was very popular in underground circles, widely spread by hand-written-copies. From 1979-1988, the CUSPEA program enrolled hundreds of China's best graduate students into physics departments in American universities. Although Wu herself was not

  11. Double soft limit of the graviton amplitude from the Cachazo-He-Yuan formalism

    Science.gov (United States)

    Saha, Arnab Priya

    2017-08-01

    We present a complete analysis for double soft limit of graviton scattering amplitude using the formalism proposed by Cachazo, He, and Yuan. Our results agree with that obtained via Britto-Cachazo-Feng-Witten (BCFW) recursion relations in [T. Klose, T. McLoughlin, D. Nandan, J. Plefka, and G. Travaglini, Double-soft limits of gluons and gravitons, J. High Energy Phys. 07 (2015) 135., 10.1007/JHEP07(2015)135]. In addition we find precise relations between degenerate and nondegenerate solutions of scattering equations with local and nonlocal terms in the soft factor.

  12. The yuan-dollar parity and its effects on Mexico's exports of manufacturing goods

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Cuevas Ahumada

    2014-06-01

    Full Text Available This paper evaluates the impact of Chinese exchange rate policy on Mexican manufacturing exports in the US market. To that end, an amplified export function which combines demandand supply-side variables is estimated. The empirical evidence shows that, in the long run, a real depreciation of the yuan visà- vis the US dollar reduces Mexican manufacturing sales in the US. The econometric work also suggests that lowering unit labor costs, perhaps by means of a comprehensive and coherent training policy package, could serve the purpose of offsetting the negative effects of an undervalued Chinese currency.

  13. Interlopers, Rogues, or Cosmopolitans? Wu Jianzhang and Early Modern Commercial Networks on the China Coast

    Directory of Open Access Journals (Sweden)

    Peter C. Perdue

    2017-12-01

    Full Text Available After the First Opium War (1839–1842, British and American merchants negotiated with Chinese officials in Shanghai to work out the framework of the new treaty port regime. One key player in these negotiations was Wu Jianzhang, a Cantonese merchant who became circuit intendant of the Shanghai region. Wu, however, also had links to Cantonese sailors and anti-Qing secret societies. When the Small Swords Society took Shanghai in 1853, he found himself entangled in conflicting responsibilities and networks. Foreign traders and Chinese officials regarded Wu, like other middlemen on the Chinese coast, with a mixture of respect and distrust. Wu’s situation, however, was not unique to the mid-nineteenth century. This article compares Wu to other intermediaries who played similar roles in the sixteenth and late nineteenth centuries, in order to show the ways in which Wu, his predecessors, and those who followed in his footsteps connected China to the wider world by navigating the treacherous waters of diplomacy, war, and commerce. The work of John K. Fairbank, who in the 1950s pioneered the study of such people as Wu Jianzhang, can find new meaning in the twenty-first century, enabling us to understand the transnational implications of China’s local social history.

  14. Ray Wu as Fifth Business: Deconstructing collective memory in the history of DNA sequencing.

    Science.gov (United States)

    Onaga, Lisa A

    2014-06-01

    The concept of 'Fifth Business' is used to analyze a minority standpoint and bring serious attention to the role of scientists who play a galvanizing role in a science but for multiple reasons appear less prominently in more common recounts of any particular development. Biochemist Ray Wu (1928-2008) published a DNA sequencing experiment in March 1970 using DNA polymerase catalysis and specific nucleotide labeling, both of which are foundational to general sequencing methods today. The scant mention of Wu's work from textbooks, research articles, and other accounts of DNA sequencing calls into question how scientific collective memory forms. This alternative history seeks to understand why a key figure in nucleic acid sequence analysis has remained less visibly connected or peripheral to solidifying narratives about the history of DNA sequencing. The study resists predictable dismissals of Wu's work in order to seriously examine the formation of his nucleic acid sequence analysis research program and how he shared his knowledge of sequencing during a period of rapid advancement in the field. An analysis of Wu's work on sequencing the cohesive ends of lambda bacteriophage in the 1960s and 1970s exemplifies how a variety of individuals and groups attempted to develop protocol for sequencing the order of nucleotide base pairs comprising DNA. This historical examination of the sociality of scientific research suggests a way to understand how Wu and others contributed to the very collective memory of DNA sequencing that Wu eventually tried to repair. The study of Wu, who was a Chinese immigrant to the United States, provides a foundation for further critical scholarship on the heterogeneous histories of Asian American bioscientists, the sociality of their scientific works, and how the resulting knowledge produced is preserved, if not evenly, in a scientific field's collective memory. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. The Hintermann-Merlini-Baxter-Wu and the infinite-coupling-limit Ashkin-Teller models

    Energy Technology Data Exchange (ETDEWEB)

    Huang Yuan, E-mail: huangy22@mail.ustc.edu.cn [Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Deng Youjin, E-mail: yjdeng@ustc.edu.cn [Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Jacobsen, Jesper Lykke, E-mail: jacobsen@lpt.ens.fr [Laboratoire de Physique Theorique, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Universite Pierre et Marie Curie, 4 place Jussieu, 75252 Paris (France); Salas, Jesus, E-mail: jsalas@math.uc3m.es [Grupo de Modelizacion, Simulacion Numerica y Matematica Industrial, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911 Leganes (Spain); Grupo de Teorias de Campos y Fisica Estadistica, Instituto Gregorio Millan, Universidad Carlos III de Madrid, Unidad asociada al IEM-CSIC, Madrid (Spain)

    2013-03-11

    We show how the Hintermann-Merlini-Baxter-Wu model (which is a generalization of the well-known Baxter-Wu model to a general Eulerian triangulation) can be mapped onto a particular infinite-coupling-limit of the Ashkin-Teller model. We work out some mappings among these models, also including the standard and mixed Ashkin-Teller models. Finally, we compute the phase diagram of the infinite-coupling-limit Ashkin-Teller model on the square, triangular, hexagonal, and kagome lattices.

  16. Impact of Mézières Rehabilitative Method in Patients with Parkinson’s Disease: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Teresa Paolucci

    2017-01-01

    Full Text Available The aim of this study was to assess the efficacy of Mézières method in improving trunk flexibility of the back muscles and balance in patients with Parkinson’s disease (PD. Materials and Methods. Thirty-six patients were randomized into 2 groups: the Mézières treatment group and the control group (home exercise group. The primary outcome was the improvement in balance per the Berg Balance Scale (BBS and the trunk flexibility of the back for the anterior flexion trunk test. Also, we evaluated pain, gait balance for the Functional Gait Assessment (FGA, disease-related disability for the Modified Parkinson’s Activity Scale and the Unified Parkinson’s Disease Rating Scale (UPDRS, the quality of life, and the functional exercise capacity. All the measures were evaluated at baseline (T0, at the end of the rehabilitative program (T1, and at the 12-week follow-up (T2. Results. In the Mézières group, the BBS (p<.001 and trunk flexion test (p<.001 improved significantly at T1 and remained the same at T2. Between groups, significant changes were reported in FGA (p=.027 and UPDRS Total (p=.007 at T1 and in FGA (p=.03 at T2. Conclusion. The Mézières approach is efficacious in improving the flexibility of the trunk and balance in PD patients.

  17. Cultivating a "Jian Zi": Exploring an Art Teacher's Responsive Pedagogy for the Development of Art Talent in Taiwan

    Science.gov (United States)

    Chen, Wei-Ren

    2017-01-01

    This qualitative case study explored the operational curricula of an art teacher's responsive pedagogy that focused on the differentiation aspects for artistically talented students in an elementary school in Taiwan. Findings indicate that cultivating a "Jian Zi" is the heart of the value system embedded in the art teacher's responsive…

  18. Study on elemental features of Longquan celadon at Fengdongyan kiln site in Yuan and Ming Dynasties by EDXRF

    Energy Technology Data Exchange (ETDEWEB)

    Li, L. [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yu Quan Lu, Beijing 100049 (China); Feng, S.L., E-mail: fengsl@ihep.ac.cn [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yu Quan Lu, Beijing 100049 (China); Feng, X.Q.; Xu, Q.; Yan, L.T.; Ma, B.; Liu, L. [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yu Quan Lu, Beijing 100049 (China)

    2012-12-01

    The energy dispersive X-ray fluorescence (EDXRF) is used to determine the chemical compositions of Longquan celadon body and glaze at Fengdongyan kiln in Yuan and Ming Dynasties. In order to analyze the elemental features in different cultural periods, 196 typical Longquan celadon shards are selected including the Early Yuan (EY), the Middle and Late Yuan (MLY), the Early Ming (EM) and the Middle Ming (MM) periods. The results indicate that the contents of K{sub 2}O, CaO, TiO{sub 2} and Fe{sub 2}O{sub 3} for celadon body and glaze are various in different cultural periods. The b values b=RO/(RO+R{sub 2}O), RO represents for alkali-earth metal elements and R{sub 2}O stands for alkali metal elements) show that the glazes of Longquan celadon in Yuan and Ming Dynasties belong to the category of calcium-alkali glaze. The principal component analysis (PCA) exhibits that the raw materials used for body and glaze in four periods have the inheritance relation. The only difference is that the raw materials for glaze in MM period were similar to those in EM period. The producing and firing technology of Longquan celadon had reached a higher level in the Early Ming Dynasty.

  19. On the de Rham–Wu decomposition for Riemannian and Lorentzian manifolds

    International Nuclear Information System (INIS)

    Galaev, Anton S

    2014-01-01

    It is explained how to find the de Rham decomposition of a Riemannian manifold and the Wu decomposition of a Lorentzian manifold. For that it is enough to find parallel symmetric bilinear forms on the manifold, and do some linear algebra. This result will allow to compute the connected holonomy group of an arbitrary Riemannian or Lorentzian manifold. (paper)

  20. Rap and Resistance: A Social Movement of the Wu-Tang Clan.

    Science.gov (United States)

    Chasteen, Amy L.; Shriver, Thomas

    1998-01-01

    Examines specific collective identity and political expression of the rap group the Wu-Tang Clan. Reveals a multi-layered political strategy that has been conscientiously designed and implemented to instigate a social movement. Prioritizes the voices of marginalized Black peoples and provides raw narratives about oppression. (MMU)

  1. Analysing the Wu metric on a class of eggs in Cn–II

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 127; Issue 3. Analysing the Wu metric on a class of eggs in C C n – I I .... G P BALAKUMAR1 PRACHI MAHAJAN2. Indian Statistical Institute, Chennai 600 113, India; Department of Mathematics, Indian Institute of Technology – Bombay, Mumbai 400 076, India ...

  2. Analysing the Wu metric on a class of eggs in ℂn – I

    Indian Academy of Sciences (India)

    G P BALAKUMAR

    An explicit description of the Wu metric on the Thullen domains (these are also ..... K(p,v), when p varies across Z. It suffices to focus attention on the case when p varies ... Substituting this into (6.3) and dividing throughout by ˜t2| ˆw|2p2. 1.

  3. Strength-based Supervision: Frameworks, Current Practice, and Future Directions A Wu-wei Method.

    Science.gov (United States)

    Edwards, Jeffrey K.; Chen, Mei-Whei

    1999-01-01

    Discusses a method of counseling supervision similar to the wu-wei practice in Zen and Taoism. Suggests that this strength-based method and an understanding of isomorphy in supervisory relationships are the preferred practice for the supervision of family counselors. States that this model of supervision potentiates the person-of-the-counselor.…

  4. Investigation of the Livengood–Wu integral for modelling autoignition in a high-pressure bomb

    NARCIS (Netherlands)

    Hu, Zhixin; Somers, Bart L.M.T.; Cracknell, Roger F.; Bradley, Derek

    2016-01-01

    The reaction progress variable, which is widely used in premixed and diffusion combustion studies, comprises a set of pre-selected intermediate species to denote reaction progress. Progress towards autoignition can also be traced by the Livengood–Wu (LW) integral. Autoignition occurs when the LW

  5. [Comparison of academic viewpoints between Yun Tie-qiao and Lu Yuan-lei].

    Science.gov (United States)

    Yang, Zhi-qing; Bi, Li-juan; Yang, Xing-lin

    2010-07-01

    Both Yun Tie-qiao and Lu Yuan-lei are medical professionals coming from the literary field with versatile and in-depth knowledge and extensive experience in medical education and clinical practice, all closely related to modern TCM development. Yun, the elder, insisted on reforming TCM and was early to advocate the academic idea of amalgamating western and traditional Chinese medicine; while Lu, the younger, insisted on the idea of "scientizing TCM" and was the representative of amalgamating western and traditional Chinese medicine in the later stage. They shared many common viewpoints, including venerating Zhang Zhongjing, stressing exogenous cold pathogens, advocating reformation and amalgamation of western medicine and TCM and objecting to the abolishment of TCM. However, there were discrepancies between them, including the relationship between the Inner Canon and the Essay on Exogenous Cold Diseases, warm disease theory, pulse theory, titles of TCM diseases and Japanese Kampo medicine. A comparison of them and noting their valuable contributions will be beneficial for the promotion of the development of TCM.

  6. Numerical evidence for quadrupolar-octopolar order in RETM{sub 2}(Al,Zi){sub 20}

    Energy Technology Data Exchange (ETDEWEB)

    Attig, Jan [Institute for Theoretical Physics, University of Cologne (Germany); Tse, Darrell; Lee, Eric Kin-Ho; Paramekanti, Arun; Kim, Yong Baek [Department of Physics, University of Toronto, ON (Canada)

    2016-07-01

    Motivated by recent experiments on materials of the type RETM{sub 2}(Al,Zi){sub 20} (where RE is a rare earth and TM a transition metal element) we investigate a minimal model for the pseudo-spin degrees of freedom of the rare earth ions. The model is described by J1-J2 pseudo-spin interactions in three-dimensions where the XY part models quadrupolar order and the Ising part models octopolar order. We use various computational methods such as simulating annealing to find the zero temperature phase digram and investigate further by using single-spin flip Monte Carlo simulations for finite temperature. One notable finding is the existence of non-coplanar spiral ordering of pseudo-spins, which may explain some of the experimental data on the electronic ordering in RETM{sub 2}(Al,Zi){sub 20}.

  7. Mellin-Barnes regularization, Borel summation and the Bender-Wu asymptotics for the anharmonic oscillator

    International Nuclear Information System (INIS)

    Kowalenko, V.; Rawlinson, A.A.

    1998-01-01

    We introduce the numerical technique of Mellin-Barnes regularization, which can be used to evaluate both convergent and divergent series. The technique is shown to be numerically equivalent to the corresponding results obtained by Borel summation. Both techniques are then applied to the Bender-Wu formula, which represents an asymptotic expansion for the energy levels of the anharmonic oscillator. We find that this formula is unable to give accurate values for the ground state energy, particularly when the coupling is greater than 0.1. As a consequence, the inability of the Bender-Wu formula to yield exact values for the energy level of the anharmonic oscillator cannot be attributed to its asymptotic nature. (authors)

  8. VizieR Online Data Catalog: ROSAT detected quasars. II. (Yuan+ 1998)

    Science.gov (United States)

    Yuan, W.; Brinkmann, W.; Siebert, J.; Voges, W.

    1997-11-01

    We have compiled a sample of all radio-quiet quasars or quasars without radio detection from the Veron-Cetty - Veron catalogue (1993, VV93, Cat. ) detected by ROSAT in the ALL-SKY SURVEY (RASS, Voges 1992, in Proc. of the ISY Conference `Space Science', ESA ISY-3, ESA Publications, p.9, See Cat. ), as targets of pointed observations, or as serendipitous sources from pointed observations publicly available from the ROSAT point source catalogue (ROSAT-SRC, Voges et al. 1995, Cat. ). For all sources we used the results of the Standard Analysis Software System (SASS, Voges et al. 1992, in Proc. of the ISY Conference `Space Science', ESA ISY-3, ESA Publications, p.223), employing the most recent processing for the Survey data (RASS-II, Voges et al. 1996, Cat. ). The total number of quasars is 846. 69 of the radio-quiet objects with radio detections have already been presented in a previous paper (Brinkmann, Yuan, & Siebert 1997, Cat. ) using the RASS-I results. 17 objects were found to be radio-loud from recent radio surveys and were marked in the table. When available, the power law photon indices and the corresponding absorption column densities (NH) were estimated from the two hardness ratios given by the SASS, both with free fitted NH and for Galactic absorption. The unabsorbed X-ray flux densities in the ROSAT band (0.1-2.4keV) were calculated from the count rates using the energy to counts conversion factor for power law spectra and Galactic absorption. As the photon index we used the value obtained for the individual source if the estimated 1-σ error is smaller than 0.5, otherwise we used the redshift-dependent mean value (see the paper for details). (1 data file).

  9. The complete mitochondrial genome of a stonefly species, Kamimuria chungnanshana Wu, 1948 (Plecoptera: Perlidae).

    Science.gov (United States)

    Wang, Kai; Ding, Shuangmei; Yang, Ding

    2016-09-01

    This study determined the complete mitochondrial (mt) genome of the stonefly, Kamimuria chungnanshana Wu, 1948. The mt genome is 15, 943 bp in size and contains 37 canonical genes which include 22 transfer RNA genes, 13 protein-coding genes, and two ribosomal RNA genes, the control region is 1062 bp in length. The phylogenetic tree shows that Kamimuria chungnanshana is sister group of Kamimuria wangi.

  10. Madame Wu Chien-Shiung the first lady of physics research

    CERN Document Server

    Chiang, Tsai-Chien

    2014-01-01

    Narrating the well-lived life of the "Chinese Madame Curie" - a recipient of the first Wolf Prize in Physics (1978), the first woman to receive an honorary doctorate from Princeton University, as well as the first female president of the American Physics Society - this book provides a comprehensive and honest account of the life of Dr. Chien-Shiung Wu, an outstanding and leading experimental physicist of the 20th century.

  11. Kladná elektroda na bázi MnOx pro PEMFC

    OpenAIRE

    Šmídek, Miroslav

    2011-01-01

    Předkládaná bakalářská práce uvádí do problematiky vodíkových palivových článků a zaměřuje se na nízkoteplotní palivové články s polymerním elektrolytem (PEMFC). Základním zaměřením práce je studium vlastností katalyzátorů na bázi MnOx na reálném palivovém článku typu PEMFC. Výstupem jsou pak změřené charakteristiky takto vytvořeného palivového článku. Construed bachelor work features into problems hydrogen fuel articles and survey on low-temperature fuell elements with polymeric electroly...

  12. Phylogeography of Sophora moorcroftiana Supports Wu's Hypothesis on the Origin of Tibetan Alpine Flora.

    Science.gov (United States)

    Cheng, Shanmei; Qiong, La; Lu, Fan; Yonezawa, Takahiro; Yin, Ganqiang; Song, Zhiping; Wang, Yuguo; Yang, Ji; Zhang, Wenju

    2017-06-01

    Wu hypothesized that the Tibetan flora originated mostly from the paleotropical Tertiary flora in the Hengduan Mountains by adapting to the cold and arid environments associated with the strong uplift of the Qinghai-Tibet Plateau (QTP). Here, we combine the phylogeographic history of Sophora moorcroftiana with that of Sophora davidii to explore the speciation of S. moorcroftiana to test this hypothesis. We collected 151 individuals from 17 populations and sequenced 2 chloroplast fragments and the internal transcribed spacer of rDNA. Five chlorotypes and 9 ribotypes were detected but no significant phylogeographic structure was revealed. The integrated results of phylogeographic studies of these 2 species clearly support the progenitor-derivative relationship between them. We infer that the western peripheral population of S. davidii migrated westwards from the Hengduan Mountains to the middle reaches of the Yarlung Zangbo River and differentiated from its ancestor in the process of adaptation to increasingly cold and arid environments with the uplift of the QTP and finally evolved into S. moorcroftiana during the Late Pliocene. In addition, our findings shed light on the idea that natural selection, as imposed by climate differentiation (especially mean diurnal range and precipitation seasonality), directly drove this peripatric speciation event after geographic isolation. The speciation of S. moorcroftiana is a strong case supporting Wu's hypothesis about the origin of Tibet's flora. © The American Genetic Association 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Effects of electroacupuncture and electroacupuncture plus Tao Hong Si Wu Wan in treating primary dysmenorrhea.

    Science.gov (United States)

    Miao, Edwin Yong; Miao, Miranda Yi-mo; Kildea, Daniel George; Lao, Yi-Wen

    2014-02-01

    This study investigated the efficacies of electroacupuncture and electroacupuncture combined with Tao Hong Si Wu Wan in treating primary dysmenorrhea and compared the results with those obtained using conventional medical treatment. One treatment group, group 1, was administered Tao Hong Si Wu Wan (2625 mg) while the other, group 2, was administered a placebo (2625 mg) twice daily for 3 months. Electroacupuncture was used in both treatment groups: two sessions per menstrual cycle for three menstrual cycles. The reference group, group 3, was administered ibuprofen, 600 mg, twice daily, for five menstrual cycles. Uses of the herb, placebo and ibuprofen were blinded. A ridit analysis was used for testing and interpreting the effects of treatment. Pain intensity was determined using a qualitative grading method in a blinded manner. The ridit scores in groups 1 and 2 were significantly higher than those in reference group immediately after treatment and three months later. Twelve months after the treatment, group 1 had a higher ridit score than group 2. In comparison to the reference group, groups 1 and 2 achieved better menstrual pain relief both immediately and 3 months after treatment. In addition, group 1 had better long-term pain relief than group 2. Copyright © 2014. Published by Elsevier B.V.

  14. Ignition delay time correlation of fuel blends based on Livengood-Wu description

    KAUST Repository

    Khaled, Fathi

    2017-08-17

    In this work, a universal methodology for ignition delay time (IDT) correlation of multicomponent fuel mixtures is reported. The method is applicable over wide ranges of temperatures, pressures, and equivalence ratios. n-Heptane, iso-octane, toluene, ethanol and their blends are investigated in this study because of their relevance to gasoline surrogate formulation. The proposed methodology combines benefits from the Livengood-Wu integral, the cool flame characteristics and the Arrhenius behavior of the high-temperature ignition delay time to suggest a simple and comprehensive formulation for correlating the ignition delay times of pure components and blends. The IDTs of fuel blends usually have complex dependences on temperature, pressure, equivalence ratio and composition of the blend. The Livengood-Wu integral is applied here to relate the NTC region and the cool flame phenomenon. The integral is further extended to obtain a relation between the IDTs of fuel blends and pure components. Ignition delay times calculated using the proposed methodology are in excellent agreement with those simulated using a detailed chemical kinetic model for n-heptane, iso-octane, toluene, ethanol and blends of these components. Finally, very good agreement is also observed for combustion phasing in homogeneous charge compression ignition (HCCI) predictions between simulations performed with detailed chemistry and calculations using the developed ignition delay correlation.

  15. Analisis Perbandingan Risiko Nilai Tukar Kurs Dinar (Emas, Dolar AS, Euro dan Yuan (Periode 2010 – 2015

    Directory of Open Access Journals (Sweden)

    Andi Triyawan

    2017-12-01

    Full Text Available Money is a tool intermediary humans to perform the transaction  payment  is national or international. In its development money undergoes several changes. Similarly, in the development of the world economy, there has been a financial crisis that hit in various countries, such as the global economic crisis. Crisis economic global is the crisis that occurred as a result of the problems of economic markets in the whole world who make entire sectors of the economy markets experienced a collapse and the impact on other sectors . Which becomes a problem in terms of this is the risk of the value of the exchange currency money and the occurrence of fluctuations in the value of exchange currency money internationally which led to a decrease in the value of the exchange currency for money in countries developing. That is, because the use of fiat money system based only on the belief of its value without any intrinsic value in fiat money form . The purpose of this research is to know how big is the risk of the value of exchange and volatility that is generated in the use of value exchange currency currency exchange rate of Dinar ( Gold , Dollars USA, Euro and Yuan as the eyes of money internationally. This research is a study of Library Research with quantitative research type, by obtaining secondary data from site Internet. By taking samples as much as 60 months of each exchange Dinar Gold, Dollars USA, Euro and Yuan by way of purposive sampling and using the Analysis Time Series with Eviews 7.2. The results of the research of this is that the volatility of the value of the exchange currency for money top is Dinar Emas with value of 0.036590, while the volatility of most small is the value of the exchange currency Yuan with a value of 0.018472. Dinar Gold has a value of volatility and risk value of the exchange of the most high , so that when the dinar gold is used in terms of trade internationally and the company would have borne the risk of market

  16. Orbinia wui, a new species from China, with redescription of O. dicrochaeta Wu, 1962 (Annelida, Orbiniidae).

    Science.gov (United States)

    Sun, Yue; Li, Xinzheng

    2018-04-04

    Two species of the genus Orbinia Quatrefages, 1865 are described including Orbinia dicrochaeta Wu, 1962 and Orbinia wui sp. n. The new species can easily be identified from other species in the genus by a combination of characters: branchiae first present from chaetiger 5, thoracic region with 14-16 chaetigers; first six thoracic neuropodia with 4-5 rows of uncini, with the last row short and curving ventral to anterior rows; subsequent thoracic neuropodia with four rows of subuluncini and one short row of uncini, arranged more densely than anterior chaetigers; both uncini and subuluncini surrounded by long sheath all of its length on concave side, sheath with developed transverse rows of barbs. This study suggests that the species of Orbinia may be divided into two groups. A taxonomic key and comparative table to all species of Orbinia is provided.

  17. Prof. Wu Xiaoqiu:China Is Striving for the World's Most Developed Capital Market

    Institute of Scientific and Technical Information of China (English)

    Sun Yongjian; Zhang Yue

    2007-01-01

    @@ China's capital market is a hot issue in the new year. The best strategy to develop the Chinese capital market in the coming 15 to 20 years was discussed in the China Capital Market Forum, which was held in China at Renmin University on January 13. Government officials, scholars, and entrepreneurs commented that by 2020, the Chinese capital market will develop into one of the best capital markets in the world,not only in terms of size, but also asset quality, liquidity and dynamic trade. Is this a realistic goal? What steps should we take to pursue this target? With these questions in mind, after the forum, China's Foreign Trade interviewed Prof. Wu Xiaoqiu, Vice President of Renmin University of China,and the Director of the Finance & Securities Institute of Renmin University.

  18. Using Dedications to Charles VI to Convey Political Messages: Honorat Bovet, Philippe de Mézières, Christine de Pizan, and Pierre Salmon

    DEFF Research Database (Denmark)

    Bourassa, Kristin

    2018-01-01

    The dedication of four French-language advice books to King Charles VI of France (r. 1380-1422), two just after the king’s declaration of personal rule (Philippe de Mézières’ Songe du viel pelerin and Honorat Bovet’s Arbre des batailles, both 1389) and two during the period dominated by Charles’s...

  19. A Response to Professor Wu Zongjie's "Interpretation, Autonomy, and Transformation: Chinese Pedagogic Discourse in a Cross-Cultural Perspective"

    Science.gov (United States)

    Curran, Thomas D.

    2014-01-01

    In response to an essay by Prof Wu Zongjie that was published in the "Journal of Curriculum Studies" [43(5), (2011), 569-590], I argue that, despite dramatic changes that have taken place in the language of Chinese academic discourse and pedagogy, evidence derived from the fields of psychology and the history of Chinese educational…

  20. 31 july 2014 - H. WU Ambassador Permanent Representative of the People's Republic of China to the United Nations

    CERN Multimedia

    Egli, Laurent

    2014-01-01

    His Excellency Mr Hailong WU Ambassador Permanent Representative of the People's Republic of China to the United Nations Office at Geneva and other international organizations in Switzerland visiting the ATLAS cavern with ATLAS Spokesperson D. Charlton and the LHC tunnel at Point 1 with Technology Department, Vacuum, Surfaces and Coatings Group P. Cruikshank.

  1. Effect of Zi Gui decoction on immune function in {sup 60}Co {gamma}-ray irradiated mice

    Energy Technology Data Exchange (ETDEWEB)

    Qiujun, Lu; Shafei, Huang; Xipeng, Zhou; Jiayun, Song; Zhongxiong, Tang [Dept. of Pharmacology, Institute of Radiation Medicine, Beijing (China)

    1995-02-01

    Zi Gui decoction (ZG), a complex preparation of traditional Chinese herbal medicine, mainly consists of Radix Angelicae and Radix Astragali. The effects of ZG on mitogen induced proliferation IL-1 and -2 production, natural killer (NK) cell activity in {sup 60}Co {gamma}-ray irradiated mice is investigated. After 5 Gy whole body irradiation. mice were treated i.g. with ZG (1.2, 1.8 g/kg/day) for 20 days. An enhancement in Con A- and LPS-induced proliferations of splenocytes from the two dosage groups were observed. There were marked increases in IL-1 activity in peritoneal macrophage culturesa and IL-2 activity in splenocyte cultures from irradiated mice treated with ZG. The two dosage groups also showed significant potentiation of NK cell activity against YAC-1 target cells. The above results indicated that ZG could promote the recovery of immune functions in {gamma}-ray irradiated mice.

  2. Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"

    Science.gov (United States)

    Tan, Sor-Hoon

    2011-01-01

    This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it…

  3. Dark energy fingerprints in the nonminimal Wu-Yang wormhole structure

    Science.gov (United States)

    Balakin, Alexander B.; Zayats, Alexei E.

    2014-08-01

    We discuss new exact solutions to nonminimally extended Einstein-Yang-Mills equations describing spherically symmetric static wormholes supported by the gauge field of the Wu-Yang type in a dark energy environment. We focus on the analysis of three types of exact solutions to the gravitational field equations. Solutions of the first type relate to the model, in which the dark energy is anisotropic; i.e., the radial and tangential pressures do not coincide. Solutions of the second type correspond to the isotropic pressure tensor; in particular, we discuss the exact solution, for which the dark energy is characterized by the equation of state for a string gas. Solutions of the third type describe the dark energy model with constant pressure and energy density. For the solutions of the third type, we consider in detail the problem of horizons and find constraints for the parameters of nonminimal coupling and for the constitutive parameters of the dark energy equation of state, which guarantee that the nonminimal wormholes are traversable.

  4. Monte Carlo study of the pure and dilute Baxter-Wu model

    International Nuclear Information System (INIS)

    Schreiber, Nir; Adler, Joan

    2005-01-01

    We studied the pure and dilute Baxter-Wu (BW) models using the Wang-Landau (WL) sampling method to calculate the density-of-states (DOS). We first used the exact result for the DOS of the Ising model to test our code. Then we calculated the DOS of the dilute Ising model to obtain a phase diagram, in good agreement with previous studies. We calculated the energy distribution, together with its first, second and fourth moments, to give the specific heat and the energy fourth order cumulant, better known as the Binder parameter, for the pure BW model. For small samples, the energy distribution displayed a doubly peaked shape, and finite size scaling analysis showed the expected reciprocal scaling of the positions of the peaks with L. The energy distribution yielded the expected BW α = 2/3 critical exponent for the specific heat. The Binder parameter minimum appeared to scale with lattice size L with an exponent θ B equal to the specific heat exponent. Its location (temperature) showed a large correction-to-scaling term θ 1 = 0.248 ± 0.025. For the dilute BW model we found a clear crossover to a single peak in the energy distribution even for small sizes and the expected α = 0 was recovered

  5. Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.

    Science.gov (United States)

    Tian, Y E; Teng, Li-Rong; Wang, Zhen-Zuo; Zhao, Min; Meng, Qing-Fan; Lu, Jia-Hui; Tian, Jian-Ming; Zhang, Wei-Wei; Zheng, Xiaoyi; Wang, D I; Teng, LE-Sheng

    2015-06-01

    Jia-Yuan-Qing pill (JYQP) composed of Porcellio laevis Latreille, Corydalis Rhizoma and Radix Cynanchi Paniculati at a ratio of 9:7:7 has been found to be an effective analgesic agent. The present study aimed to evaluate the safety, addictive potential and anti-cancer pain activity of JYQP in a rat model. During the 6-month chronic toxicity test, no significant changes in general behavior, defecation, postural abnormalities, dietary or water intake or blood biochemical parameters were observed in male and female rats. Although a high dose of JYQP (5 g/kg) caused swelling of the liver, spleen and kidney in male and female rats, no pathological changes were observed in all organs examined via hematoxylin and eosin staining. The analgesic effect of JYQP on bone cancer pain was successfully confirmed in a rat model of Walker 256 cell-induced bone cancer. In contrast to morphine, in a physical dependence test, JYQP produced no withdrawal symptoms following chronic administration. The data from this study provide experimental evidence supporting the clinical use of JYQP as an effective, safe and non-addictive agent for the treatment of bone cancer pain.

  6. Multi-objective Operation Chart Optimization for Aquatic Species Habitat Conservation of Cascaded Hydropower System on Yuan River, Southwestern China

    Science.gov (United States)

    Wen, X.; Lei, X.; Fang, G.; Huang, X.

    2017-12-01

    Extensive cascading hydropower exploitation in southwestern China has been the subject of debate and conflict in recent years. Introducing limited ecological curves, a novel approach for derivation of hydropower-ecological joint operation chart of cascaded hydropower system was proposed, aiming to optimize the general hydropower and ecological benefits, and to alleviate the ecological deterioration in specific flood/dry conditions. The physical habitat simulation model is proposed initially to simulate the relationship between streamflow and physical habitat of target fish species and to determine the optimal ecological flow range of representative reach. The ecological—hydropower joint optimization model is established to produce the multi-objective operation chart of cascaded hydropower system. Finally, the limited ecological guiding curves were generated and added into the operation chart. The JS-MDS cascaded hydropower system on the Yuan River in southwestern China is employed as the research area. As the result, the proposed guiding curves could increase the hydropower production amount by 1.72% and 5.99% and optimize ecological conservation degree by 0.27% and 1.13% for JS and MDS Reservoir, respectively. Meanwhile, the ecological deterioration rate also sees a decrease from 6.11% to 1.11% for JS Reservoir and 26.67% to 3.89% for MDS Reservoir.

  7. A new species of Nemoura (Plecoptera: Nemouridae) from Jiangsu Province, China, with new illustrations for Nemoura nankinensis Wu.

    Science.gov (United States)

    Chen, Zhi-Teng; DU, Yu-Zhou

    2017-04-12

    A new species of Nemoura (Plecoptera: Nemouridae), N. fusiformis sp. nov. from Jiangsu Province, China, is described and illustrated. The new species is characterized by a strongly sclerotized large hook formed by outer margin of the outer lobe of the paraproct and by the outer sclerite of cercus with a sub-triangular medial process. The new species is compared with similar taxa. Additionally, supplementary illustrations for N. nankinensis Wu, 1926 are also provided.

  8. PLE-wu, a new member of piggyBac transposon family from insect, is active in mammalian cells.

    Science.gov (United States)

    Wu, Chunxiao; Wang, Shu

    2014-10-01

    piggyBac, a highly active transposon in insect and mammalian cells, is a very useful tool in genome manipulation. A new piggyBac-like element (PLE), named PLE-wu, was identified from a mutant baculovirus cultured in sf9 insect cells. This new transposon is 2931 bp in length and encodes two active forms of transposase, a 708-amino acid-long transposase and a short 576-residue-long transposase translated from a downstream in-frame initiation codon. PLE-wu has asymmetric terminal structures, containing 6-bp inverted terminal repeats, 32-bp imperfect inverted and direct sub-terminal repeats. Similar to piggyBac, PLE-wu exhibits traceless excision activity in both insect and mammalian cells, restoring the original TTAA target sequence upon excision. It also retains the insertion activity in mammalian cells with a plasmid to chromosome transposition rate about 10-fold higher than random integration. Plasmid rescue assays revealed that the TTAA target sequence was duplicated at the junctions of the insertion site. Deletion of the terminal sequences including the sub-terminal repeats decreased the transposition activity of the 708-residue-long transposase, while the transposition activity of the short form of transposase was not affected. With its low sequence similarity to piggyBac, PLE-wu will contribute to the understanding the mechanism of PLE transposition, as well as design of new transposon systems with higher activity. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  9. MAGNETOSTRATIGRAPHY AND BIOSTRATIGRAPHY OF THE LATE TRIASSIC GURI ZI SECTION, ALBANIA: CONSTRAINT ON THE AGE OF THE CARNIAN-NORIAN BOUNDARY

    Directory of Open Access Journals (Sweden)

    GIOVANNI MUTTONI

    2005-07-01

    Full Text Available We present the magnetostratigraphy and conodont biostratigraphy across the Carnian-Norian boundary from a 70 m-thick limestone section located at Guri Zi in northern Albania. A total of 14 magnetozones were observed. The Carnian-Norian boundary is placed in a thin stratigraphic interval between the last occurrence of Paragondolella nodosa and the first occurrence of Epigondolella abneptis. Data from Guri Zi are in substantial agreement with already published data from Silicka Brezova in Slovakia and Pizzo Mondello in Sicily, which complessively indicate that the conodont Carnian-Norian boundary, when magnetostratigraphically traced onto the Newark astrochronological polarity time scale (APTS, has an age of ~228-227 Ma.

  10. Protection of nucleated bone marrow cells of mice against effect of radiation-induced micronucleus formation by using polysaccharides extracted from 'Zi Zhi' (a ganoderma)

    International Nuclear Information System (INIS)

    Chu Fang; Luo Houliang; Luo Gui; Chen Shunle; Liu Zhifang

    1988-01-01

    This paper describes the influence of polysaccharides extracted from 'Zi Zhi' (Ganoderma Sinese Zhao, Xu et Zhang) on the frequency of micronucleated cells induced by 60 Co gamma irradiation at different doses in bone marrow of mice. These polysaccharides of 'Zi Zhi' were shown to be of ability to protect nucleated bone marrow cells from micronucleus formation in irradiated mice. For Swiss mice, a dose reduction factor (DRF) was found to be 1.72 in the range of 0 to 4.728 Gy and for LACA mice, to be 1.73 in the range of 0 to 3.152 Gy. Such findings indicate that these polysaccharides are comparable to L-cysteine in their effeciency of protection

  11. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    OpenAIRE

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial...

  12. The Causes of Prosperity of Business in Yuan Dynasty%试论元朝商业繁荣的原因

    Institute of Scientific and Technical Information of China (English)

    梁凌霄; 魏楠; 李文文

    2014-01-01

    Nomads attaches great importance to business .Rulers of Yuan established water and land transporta-tion network extending in all directions after its grand unification , adopting a policy of opening to the outside world , which promoted business with west Asia countries , Europe, Africa.The government’s support, the shipbuilding industry and the progress of the seafaring are largely promoted the prosperity of the Yuan dynasty business .Yuan dynasty broken the traditional heavy farming business suppression policy , with prosperous business wrote a special page in the history of Chinese civilization .%游牧民族是重视商业的民族,蒙元统治者在大一统的国土上建立了四通八达的水陆交通网,实行对外开放政策,使得元朝西与西亚诸国、欧洲、非洲,南与缅甸等国都有商业往来。政府的支持,造船业和航海业的进步都在很大程度上促进了元朝商业的繁荣。元朝打破了传统的重农抑商政策,以繁荣的商业在中华五千年文明史上写下了别开生面的一页。

  13. The changes of densities and patterns of roads and rural buildings: a case study on Dongzhi Yuan of the Loess Plateau, China.

    Science.gov (United States)

    Bi, Xiaoli; Wang, Hui; Ge, Jianping

    2010-05-01

    Roads and buildings are considered as primary causes of rural landscape changes. In this study, linear regression models were used to analyze the dynamic influences of environmental factors and variables on roads and rural buildings from 1979 to 2005 in Dongzhi Yuan (tableland) of the Loess Plateau, China. The relationship between roads and rural buildings and their effects on Dongzhi Yuan are discussed also. The results showed that three environmental factors (topography, land cover, and development level) explained roads better than rural buildings referring densities and patterns. The environmental variables significantly related to roads have decreased, whereas those related to rural buildings have increased over time. Among these significant variables, percent of farmland mostly determined the densities and patterns of both roads and rural buildings. There was significant correlation between roads and rural buildings in terms of density and pattern. In addition, roads and rural buildings have increased greatly in gully areas of this region. Therefore, more attention should be paid to planning of roads and rural buildings in Dongzhi Yuan.

  14. Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

    Directory of Open Access Journals (Sweden)

    Chiu-Mei Chen

    2013-01-01

    Full Text Available Purpose. To explore the effects of SiJunZiTang (SJZT on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1 measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2 evaluations of monoamine (MA level in the brain; and (3 measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats’ vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg, the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P<0.05. For the experimental groups where the vagus nerves were cut, a comparison with the control group suggests that the group receiving SJZT (500 mg/kg orally for 21 days demonstrated a cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

  15. Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers.

    Science.gov (United States)

    Chen, Chiu-Mei; Lee, Chien-Ying; Lin, Po-Jung; Hsieh, Chin-Lang; Shih, Hung-Che

    2013-01-01

    Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2) evaluations of monoamine (MA) level in the brain; and (3) measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats' vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg), the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

  16. Liu Jun Zi Tang—A Potential, Multi-Herbal Complementary Therapy for Chemotherapy-Induced Neurotoxicity

    Directory of Open Access Journals (Sweden)

    Chun-Tang Chiou

    2018-04-01

    Full Text Available Liu Jun Zi Tang (LJZT has been used to treat functional dyspepsia and depression, suggesting its effects on gastrointestinal and neurological functions. LJZT is currently used as a complementary therapy to attenuate cisplatin-induced side effects, such as dyspepsia. However, its effect on chemotherapy-induced neuropathic pain or neurotoxicity has rarely been studied. Thus, we explored potential mechanisms underlying LJZT protection against cisplatin-induced neurotoxicity. We observed that LJZT attenuated cisplatin-induced thermal hyperalgesia in mice and apoptosis in human neuroblastoma SH-SY5Y cells. Furthermore, it also attenuated cisplatin-induced cytosolic and mitochondrial free radical formation, reversed the cisplatin-induced decrease in mitochondrial membrane potential, and increased the release of mitochondrial pro-apoptotic factors. LJZT not only activated the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α promoter region, but also attenuated the cisplatin-induced reduction of PGC-1α expression. Silencing of the PGC-1α gene counteracted the protection of LJZT. Taken together, LJZT mediated, through anti-oxidative effect and mitochondrial function regulation, to prevent cisplatin-induced neurotoxicity.

  17. FORTRAN Code for Glandular Dose Calculation in Mammography Using Sobol-Wu Parameters

    Directory of Open Access Journals (Sweden)

    Mowlavi A A

    2007-07-01

    Full Text Available Background: Accurate computation of the radiation dose to the breast is essential to mammography. Various the thicknesses of breast, the composition of the breast tissue and other variables affect the optimal breast dose. Furthermore, the glandular fraction, which refers to the composition of the breasts, as partitioned between radiation-sensitive glandular tissue and the adipose tissue, also has an effect on this calculation. Fatty or fibrous breasts would have a lower value for the glandular fraction than dense breasts. Breast tissue composed of half glandular and half adipose tissue would have a glandular fraction in between that of fatty and dense breasts. Therefore, the use of a computational code for average glandular dose calculation in mammography is a more effective means of estimating the dose of radiation, and is accurate and fast. Methods: In the present work, the Sobol-Wu beam quality parameters are used to write a FORTRAN code for glandular dose calculation in molybdenum anode-molybdenum filter (Mo-Mo, molybdenum anode-rhodium filter (Mo-Rh and rhodium anode-rhodium filter (Rh-Rh target-filter combinations in mammograms. The input parameters of code are: tube voltage in kV, half-value layer (HVL of the incident x-ray spectrum in mm, breast thickness in cm (d, and glandular tissue fraction (g. Results: The average glandular dose (AGD variation against the voltage of the mammogram X-ray tube for d = 4 cm, HVL = 0.34 mm Al and g=0.5 for the three filter-target combinations, as well as its variation against the glandular fraction of breast tissue for kV=25, HVL=0.34, and d=4 cm has been calculated. The results related to the average glandular absorbed dose variation against HVL for kV = 28, d=4 cm and g= 0.6 are also presented. The results of this code are in good agreement with those previously reported in the literature. Conclusion: The code developed in this study calculates the glandular dose quickly, and it is complete and

  18. Information Philosophy in China: Professor Wu Kun’s 30 Years of Academic Thinking in Information Philosophy

    Directory of Open Access Journals (Sweden)

    Guowu Li

    2011-10-01

    Full Text Available Professor Wu Kun, from Xi'an Jiaotong University of China, has been studying information philosophy for 30 years. He thinks information conception is one of the most fundamental areas in philosophy and has founded information philosophy. He has done original and pioneering research in information ontology, epistemology, social information theory, information production theory, information evolution theory, information value, and information thinking directions. He is the first scholar to develop a completely new view of theories, systems, and methods about information philosophy.

  19. His Excellency Mr Ken WU Ambassador Extraordinary and Plenipotentiary of the People’s Republic of China to Switzerland

    CERN Multimedia

    Jean Claude Gadmer

    2011-01-01

    Photo 1-5:The delegation visiting the ATLAS visitor Center with P.Jenni, ATLAS Collaboration former Spokesperson Photo 6-14,15-20:visiting the ATLAS experimental area Photo 15:Y. YANG,Attaché-Q. WAN,First Secretary-Z. Ren,ATLAS Collaboration,High Energy Group,Shandong University-H.E. Mr K. Wu-P. Jenni-R. Voss,Adviser for the People’s Republic of China-H. FENG,Counsellor Photo 21-38:Signature of the Guest Book with CERN Director-General R. Heuer

  20. [Professor WU Zhongchao's experience in the treatment of bi syndrome with fire needling therapy at lower he-sea points].

    Science.gov (United States)

    Zhou, Yu; Chen, Zhongjie; Liu, Chun; Wang, Bing; Zhang, Ning; Li, Caifen; Xie, Qian

    2016-07-12

    Bi syndrome is classified into five categories. Based on the syndrome differentiation of meridians and collaterals and zangfu theories, Professor WU Zhongchao proposed the fire needling therapy at the lower he -sea points for five types of bi syndromes. Professor WU stresses on the flexible application of fire needling therapy for bi syndrome at the lower he -sea points and innovated the unique five techniques of fire needling therapy, named lifting and threating needle of small amplitude at the lower he -sea points, the stimulation along the relevant meri-dians before fire needling, detecting the sensitive sites by gentle pressing the relevant lower he -sea points, combining the movement of affected upper limb or joint during fire needling, or combining with contralateral needling technique, and controlling the depth of fire needling based on the duration of sickness and depth of affected site. He pointed out that Shangjuxu (ST 37) is for skin bi syndrome, Zusanli (ST 36) for muscle bi syndrome, Yanglingquan (GB 34) for tendon bi syndrome, Weizhong (BL 40) for bone bi syndrome and Xiajuxu (ST 39) for vessel bi syndrome.

  1. Pašnāvības ziņu rāmējums latviešu, krievu un britu ziņu portālos: salīdzinošā analīze

    OpenAIRE

    Kozlovska, Alīna

    2014-01-01

    Bakalaura darba „Pašnāvības ziņu rāmējums latviešu, krievu un britu ziņu portālos: salīdzinošā analīze” pētāmā problēma ir pašnāvības ziņu mediācija atbilstoši ētikas principiem. Darba mērķis ir izpētīt portālu publikāciju rāmējumus un vēstījumos paustās attieksmes pret dzīves brīvprātīgu pārtraukšanu, salīdzinot dažādās mediju vidēs konstatētos rezultātus. Darba teorētiskajā daļā apskatītas interneta un jaunāko tehnoloģiju īpatnības, sensibilo tematu komunikācijas īpatnības un nāves medi...

  2. Zhuang Zi's Rhetorical Thoughts.

    Science.gov (United States)

    Wang, Haixia

    The memory of the student uprising at Tiananmen Square in 1989 invites one professor to examine more closely what she does: rhetoric and composition, especially rhetorical invention. To examine the kind of power exercised by official Chinese public discourse and whether language could help to avoid reoccurrences such as the loss of innocent…

  3. Biodesulfurization of Naphthothiophene and Benzothiophene through Selective Cleavage of Carbon-Sulfur Bonds by Rhodococcus sp. Strain WU-K2R

    Science.gov (United States)

    Kirimura, Kohtaro; Furuya, Toshiki; Sato, Rika; Ishii, Yoshitaka; Kino, Kuniki; Usami, Shoji

    2002-01-01

    Naphtho[2,1-b]thiophene (NTH) is an asymmetric structural isomer of dibenzothiophene (DBT), and in addition to DBT derivatives, NTH derivatives can also be detected in diesel oil following hydrodesulfurization treatment. Rhodococcus sp. strain WU-K2R was newly isolated from soil for its ability to grow in a medium with NTH as the sole source of sulfur, and growing cells of WU-K2R degraded 0.27 mM NTH within 7 days. WU-K2R could also grow in the medium with NTH sulfone, benzothiophene (BTH), 3-methyl-BTH, or 5-methyl-BTH as the sole source of sulfur but could not utilize DBT, DBT sulfone, or 4,6-dimethyl-DBT. On the other hand, WU-K2R did not utilize NTH or BTH as the sole source of carbon. By gas chromatography-mass spectrometry analysis, desulfurized NTH metabolites were identified as NTH sulfone, 2′-hydroxynaphthylethene, and naphtho[2,1-b]furan. Moreover, since desulfurized BTH metabolites were identified as BTH sulfone, benzo[c][1,2]oxathiin S-oxide, benzo[c][1,2]oxathiin S,S-dioxide, o-hydroxystyrene, 2-(2′-hydroxyphenyl)ethan-1-al, and benzofuran, it was concluded that WU-K2R desulfurized NTH and BTH through the sulfur-specific degradation pathways with the selective cleavage of carbon-sulfur bonds. Therefore, Rhodococcus sp. strain WU-K2R, which could preferentially desulfurize asymmetric heterocyclic sulfur compounds such as NTH and BTH through the sulfur-specific degradation pathways, is a unique desulfurizing biocatalyst showing properties different from those of DBT-desulfurizing bacteria. PMID:12147483

  4. The Economic Relationships Between China and the USA Through the Exchange Rate: A Look at the Yuan RMB-US$ Controversy from an European Perspective

    Institute of Scientific and Technical Information of China (English)

    Guido Ferrari

    2013-01-01

    In this paper,the debate on Yuan RMB & US$ exchange rate is analyzed from the financial-political point of view,supported with statistical-economic evidence in order to verify whether or not it is artificially kept undervalued,as claimed by the USA government and economists and therefore the cause of ChinaUSA strong trade imbalance which in turn affects the rate of unemployment in the USA.After discussing the different points of view in the subject,the paper stresses the strong re-valuation operated by the China 's government through the People's Bank of China,and after putting in evidence that the exchange rate cannot be imputed of being the main source of trade imbalance,concludes that the still existing undervaluation as compared to the purchasing power parity is "physiological",represents quite wellthe economic exchange rate and cannot be considered the cause of the unemployment rate in the USA.

  5. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

    Science.gov (United States)

    Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

    2010-01-15

    Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae.

  6. I Know You Are, But What Am I? : Anti-Individualism in the Development of Intellectual Humility and Wu-Wei

    NARCIS (Netherlands)

    Robinson, Brian; Alfano, M.R.

    2016-01-01

    Virtues are acquirable, so if intellectual humility is a virtue, it’s acquirable. But there is something deeply problematic—perhaps even paradoxical—about aiming to be intellectually humble. Drawing on Edward Slingerland’s analysis of the paradoxical virtue of wu-wei in Trying Not To Try, we argue

  7. Metaforu lietojums ziņu rakstos par 2016. gada ASV prezidenta vēlēšanām

    OpenAIRE

    Safronovs, Imants

    2017-01-01

    Bakalaura darbs ir veltīts metaforu lietojuma izmeklēšanai divu ASV laikrakstu (The Wall Street Journal un The New York Times) interneta vietnēs. Pētījums analizē konceptuālās metaforas lietojumu ziņu rakstos par 2016. ASV prezidenta vēlēšanām. Pētījuma mērķis ir izmeklēt konceptuālo metaforu nozīmi ASV prezidenta vēlēšanu konceptualizācijā. Pielietotā metode ir konceptuālo metaforu analīze. Apkopotie dati ļauj secināt, ka analizētajos rakstos koncetuālajām metaforām ir būtiska nozīme vēstīju...

  8. Mediji un populisms: ASV mediju dienaskārtība un ziņu atspoguļojums kā veicinošs faktors Donalda Trampa priekšvēlēšanu kampaņas atbalstam. 2011. un 2015. gada ziņu raidījumu salīdzinošā analīze

    OpenAIRE

    Aleksejeva, Santa

    2017-01-01

    Maģistra darba tēmas ir “Mediji un populisms: ASV mediju dienaskārtība un ziņu atspoguļojums kā veicinošs faktors Donalda Trampa priekšvēlēšanu kampaņas atbalstam. 2011. un 2015. gada ziņu raidījumu salīdzinošā analīze”. Pētījuma mērķis ir izpētīt mediju un populisma saikni un apstiprināt hipotēzi, ka mediju veidotā dienaskārtība un ziņu atspoguļojums par brīvo tirdzniecību, Pieejmās Aprūpes likumu un imigrāciju ASV televīzijas kanālos CNN, MSNBC un FOX News 2015. gadā ir veicinājis sabiedrīb...

  9. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  10. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2015-01-01

    Full Text Available Wu-tou decoction (WTD is a classic traditional Chinese medicine formula and has been used effectively to treat joint diseases clinically. Previous reports indicated that WTD possesses anti-inflammatory activity; however, its actions on pain have not been clarified. Here, we investigated the antinociceptive activity of WTD in CFA-induced mice, and its possible mechanism of the action associated with transient receptor potential (TRP ion channels was also explored. Our results showed that 1.58, 3.15, and 6.30 g/kg WTD significantly attenuated mechanical, cold, and heat hypersensitivities. Moreover, WTD effectively inhibited spontaneous nociceptive responses to intraplantar injections of capsaicin and cinnamaldehyde, respectively. WTD also effectively suppressed jumping and wet-dog-shake behaviors to intraperitoneal injection of icilin. Additionally, WTD significantly reduced protein expression of TRPV1 and TRPA1 in dorsal root ganglia and skins of injured paw. Collectively, our data demonstrate firstly that WTD exerts antinociceptive activity in inflammatory conditions by attenuating mechanical, cold, and heat hypersensitivities. This antinociceptive effect may result in part from inhibiting the activities of TRPV1, TRPA1, and TRPM8, and the suppression of TRPV1 and TRPA1 protein by WTD was also highly effective. These findings suggest that WTD might be an attractive and suitable therapeutic agent for the management of chronic inflammatory pain.

  11. The complete mitochondrial genome and its remarkable secondary structure for a stonefly Acroneuria hainana Wu (Insecta: Plecoptera, Perlidae).

    Science.gov (United States)

    Huang, Mingchao; Wang, Yuyu; Liu, Xingyue; Li, Weihai; Kang, Zehui; Wang, Kai; Li, Xuankun; Yang, Ding

    2015-02-15

    The Plecoptera (stoneflies) is a hemimetabolous order of insects, whose larvae are usually used as indicators for fresh water biomonitoring. Herein, we describe the complete mitochondrial (mt) genome of a stonefly species, namely Acroneuria hainana Wu belonging to the family Perlidae. This mt genome contains 13 PCGs, 22 tRNA-coding genes and 2 rRNA-coding genes that are conserved in most insect mt genomes, and it also has the identical gene order with the insect ancestral gene order. However, there are three special initiation codons of ND1, ND5 and COI in PCGs: TTG, GTG and CGA, coding for L, V and R, respectively. Additionally, the 899-bp control region, with 73.30% A+T content, has two long repeated sequences which are found at the 3'-end closing to the tRNA(Ile) gene. Both of them can be folded into a stem-loop structure, whose adjacent upstream and downstream sequences can be also folded into stem-loop structures. It is presumed that the four special structures in series could be associated with the D-loop replication. It might be able to adjust the replication speed of two replicate directions. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. [A Study on the quotations in the Wu xing da yi (The Gist of Five Phases) cited from Nei jing (Inner Canon)].

    Science.gov (United States)

    Wang, Zheng-Shan; Zhang, Qi-Cheng

    2013-07-01

    In the Wu xing da yi (The Gist of Five Phases), written by Xiao Ji of the Sui Dynasty, there were 9 quotations cited from Huang di nei jing (Inner Canon of Huangdi). By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages.

  13. 宋元泉州石建筑技术发展脉络%Development of Quanzhou Stone - Building Technology in Song - Yuan Dynasties

    Institute of Scientific and Technical Information of China (English)

    闫爱宾

    2009-01-01

    From the 11th to the 14th century, Stone architecture in Quanzhou developed into a highly- sophisticated industry. The stone bridge and multi -layered pagodas in Quanzhou are examples of some of the most developed stone architecture of their time. The origins of the technology used to construct such architecture can be traced beck to southern and central Fujian before the beginning of the Song Dynasty. This paper will examine these origins and the distribution of technology to explain the evolution of form and style within Stone architecture in Quanzhou from the Song to the Yuan Dynasty.%泉州宋元石构建筑在11至14世纪间由逐步积累而至极盛,形成了中国石建筑发展史上的一座高峰,其中尤其以石桥梁、楼阁武石塔为杰出代表.本文通过对宋以前闽中、闽南石桥梁与楼阁式石塔技术传播路线的梳理,深入解析泉州宋元石建筑形式、风格、技术的形成及演变过程.

  14. The Newly Unearthed in Jiangxi Area to Buy Land in the Song and Yuan Dynasties%新出土江西地区宋元时期买地券概述

    Institute of Scientific and Technical Information of China (English)

    李桥; 郭锐瑜

    2015-01-01

    买地券是中国古代亡者向神灵买地的契约凭证,具有很强的民间宗教色彩。通过对江西地区宋元时期买地券的研究,有助于我们了解宋元时期江西的民间信仰和丧葬习俗,丰富史学研究的成果。海棠花馆藏新出土江西地区买地券共36块,为宋元时期,出土地主要集中在江西抚州、洪州等,按其功能分为买地类、告神类、志券合一类三大类型,揭示了宋元时期买地券逐渐走向志券合一的过程,为宋元行政区划、江西地区道教信仰研究提供了重要材料,使学界对这批新出土江西地区宋元时期买地券有了全面清晰的认识。%Buy land to the deceased to the gods of ancient China to buy land contract certificate, with a strong folk religious overtones. Through the Song and Yuan dynasties in Jiangxi province to buy vouchers study helps us understand Jiangxi during the Song and Yuan folk beliefs and funeral customs, fruitful history studies. Begonia flowers in Jiangxi province to buy land holdings newly unearthed a total of 36 tickets for the Song and Yuan dynasties, the land mainly in Fuzhou, Jiangxi, Hongzhou, etc., according to their function into buying land class, tell God class, Chi coupons one three-large type, reveals the Song and Yuan dynasties buy land gradually Chi coupons unity process, the Song and Yuan administrative division, religion Taoism in Jiangxi province provides important material, so that this group of scholars during the Song and Yuan Newly Found in Jiangxi province to buy land coupons have comprehensive and clear understanding.

  15. [A molecular epidemiological study of KI polyomavirus and WU polyomavirus in children with acute respiratory infection in Tianjin, China].

    Science.gov (United States)

    Lin, Shu-Xiang; Wang, Wei; Guo, Wei; Yang, Hong-Jiang; Ma, Bai-Cheng; Fang, Yu-Lian; Xu, Yong-Sheng

    2017-07-01

    To investigate the relationship of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) with acute respiratory infection in children in Tianjin, China. A total of 3 730 nasopharyngeal secretions were collected from hospitalized children with acute respiratory infection in Tianjin Children's Hospital from January 2011 to December 2013. Viral nucleic acid was extracted, and virus infection (KIPyV and WUPyV) was determined by PCR. Some KIPyV-positive and WUPyV-positive PCR products were subjected to sequencing. Sequencing results were aligned with the known gene sequences of KIPyV and WUPyV to construct a phylogenetic tree. Amplified VP1 fragments of KIPyV were inserted into the cloning vector (PUCm-T) transformed into E. coli competent cells. Positive clones were identified by PCR and sequencing. The nucleotide sequences were submitted to GenBank. In addition, another seven common respiratory viruses in all samples were detected by direct immunofluorescence assay. In the 3 730 specimens, the KIPyV-positive rate was 12.14% (453/3 730) and the WUPyV-positive rate was 1.69% (63/3 730). The mean infection rate of KIPyV was significantly higher in June and July, while the mean infection rate of WUPyV peaked in February and March. Most of the KIPyV-positive or WUPyV-positive children were infections with KIPyV, WUPyV, and other respiratory viruses were observed in the children. The co-infection rate was 2.31% (86/3 730) and there were nine cases of co-infections with WUPyV and KIPyV. Thirty-five KIPyV-positive and twelve WUPyV-positive PCR products were sequenced and the alignment analysis showed that they had high homology with the known sequences (94%-100% vs 95%-100%). The VP1 gene sequences obtained from two KIPyV strains in this study were recorded in GenBank with the accession numbers of KY465925 and KY465926. For some children with acute respiratory infection in Tianjin, China, the acute respiratory infection may be associated with KIPyV and WUPy

  16. A diplomacia do Yuan Fraco The Yuan diplomacy

    Directory of Open Access Journals (Sweden)

    André Moreira Cunha

    2007-12-01

    Full Text Available O presente trabalho analisa as conexões entre a estratégia chinesa de desenvolvimento de longo prazo e as políticas de gestão da taxa de câmbio e dos fluxos de capitais. Argumenta-se que as segundas estão subordinadas às primeiras. Mais do que isso, o novo regime cambial implementado em 2005 é um bom exemplo de como as autoridades chinesas administram tensões contraditórias entre as pressões políticas e econômicas internas e externas.This paper analyses the connections between Chinese long-term development strategy and the policies regarding exchange rate regime and capital flows management. We argue that the second has been subordinated to the former. Moreover, the new exchange rate regime, implemented in 2005, is a good example of how Chinese authorities manage contradictories internal and external economic and political pressures.

  17. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Science.gov (United States)

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety. PMID:25793006

  18. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Lin-lin Hu

    2015-01-01

    Full Text Available Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT and Zhi Zi Chi Tang (ZZCT; SZR-ZZC for improving sleep quality and anxiety states with four indices of Polysomnography (PSG, the Insomnia Severity Index (ISI, the Pittsburgh Sleep Quality Index (PSQI, and the Self Rating Anxiety Scale (SAS. Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n=60 and the lorazepam tablet treatment group (n=59. Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P=0.029, the PSQI (P=0.017, and wake after sleep onset (WASO; P=0.008 scores and improved sleep architecture (P=0.000–0.003 after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

  19. ZiBuPiYin recipe protects db/db mice from diabetes-associated cognitive decline through improving multiple pathological changes.

    Directory of Open Access Journals (Sweden)

    Jing Chen

    Full Text Available Multiple organ systems, including the brain, which undergoes changes that may increase the risk of cognitive decline, are adversely affected by diabetes mellitus (DM. Here, we demonstrate that type 2 diabetes mellitus (T2DM db/db mice exhibited hippocampus-dependent memory impairment, which might associate with a reduction in dendritic spine density in the pyramidal neurons of brain, Aβ1-42 deposition in the prefrontal cortex (PFC and hippocampus, and a decreased expression of neurostructural proteins including microtubule-associated protein (MAP2, a marker of dendrites, and postsynaptic density 95 (PSD95, a marker of excitatory synapses. To investigate the effects of the ZiBuPiYin recipe (ZBPYR, a traditional Chinese medicine recipe, on diabetes-related cognitive decline (DACD, db/db mice received daily administration of ZBPYR over an experimental period of 6 weeks. We then confirmed that ZBPYR rescued learning and memory performance impairments, reversed dendritic spine loss, reduced Aβ1-42 deposition and restored the expression levels of MAP2 and PSD95. The present study also revealed that ZBPYR strengthened brain leptin and insulin signaling and inhibited GSK3β overactivity, which may be the potential mechanism or underlying targets of ZBPYR. These findings conclude that ZBPYR prevents DACD, most likely by improving dendritic spine density and attenuating brain leptin and insulin signaling pathway injury. Our findings provide further evidence for the effects of ZBPYR on DACD.

  20. Future changes in Yuan River ecohydrology: Individual and cumulative impacts of climates change and cascade hydropower development on runoff and aquatic habitat quality.

    Science.gov (United States)

    Wen, Xin; Liu, Zhehua; Lei, Xiaohui; Lin, Rongjie; Fang, Guohua; Tan, Qiaofeng; Wang, Chao; Tian, Yu; Quan, Jin

    2018-08-15

    The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and nonadditive ways, the purpose of this study is to predict the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify the individual and cumulative effect of cascade damming and climate change. The bias corrected and spatial downscaled Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Model (GCM) projections are employed to drive the Soil and Water Assessment Tool (SWAT) hydrological model and to simulate and predict runoff responses under diverse scenarios. Physical habitat simulation model is established to quantify the relationship between river hydrology and fish habitat, and the relative change rate is used to assess the individual and combined effects of cascade damming and climate change. Mean annual temperature, precipitation and runoff in 2015-2100 show an increasing trend compared with that in 1951-2010, with a particularly pronounced difference between dry and wet years. The ecological habitat quality is improved under cascade hydropower development since that ecological requirement has been incorporated in the reservoir operation policy. As for middle reach, the runoff change from January to August is determined mainly by damming, and climate change influence becomes more pronounced in dry seasons from September to December. Cascade development has an effect on runoff of lower reach only in dry seasons due to the limited regulation capacity of reservoirs, and climate changes have an effect on runoff in wet seasons. Climate changes have a less significant effect on fish habitat quality in middle reach than damming, but a more significant effect in lower reach. In addition, the effect of climate changes on fish habitat quality in lower reach is high

  1. A STUDY OF CHINESE YUAN (RMB APPRECIATION ACCOMPANYING WITH OTHERS FACTORS INCLUDING FOREIGN DIRECT INVESTMENT (FDI AND THEIR EFFECT ON CHINA ECONOMY

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    Ping-fu (Brian LAI

    2014-07-01

    Full Text Available The Chinese Yuan (RMB has been on the trend of appreciation over the last decade, and such a trend will likely be continuing for some years over the next decade. According to some scholars in their published literatures, the appreciation of RMB, the influx of Foreign Direct Investment (FDI has been ongoing accompanying the sustained growing economy in mainland China over the past decade. It is believed that the China economy has an implication from some significant factors including appreciation of RMB, interest rate of RMB, inflation and continuous increase of FDI for the next several years. The present study aims to provide an emphasis on investigation into effect on China economy as a result of appreciation of RMB and FDI together with some other factors, and to provide an outlook on the economy in China for the coming decades. First, a review was carried on relevant background information and development history of RMB and FDI. There are many reasons and factors behind leading to the sustained growth in the economy in China in the last decade and such effects were in coverage in the literature review. An overview of the development of RMB exchange mechanism, and other variables including (1 RMB exchange rate, (2 China interest rate, (3 Foreign Direct Investment (FDI, (4 Trade Balance of China, (5 Annual Inflation rate in China, (6 Energy Consumption in China, (7 Foreign Exchange Reserve in China, (8 China wages, (9 China External Debt and (10 China Consumer Price Index, which may have effect on the growth of the economy in China is covered in the literature review conducted in Chapter 2.

  2. Ultra high performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry for the rapid analysis of constituents in the traditional Chinese medicine formula Wu Ji Bai Feng Pill.

    Science.gov (United States)

    Duan, Shengnan; Qi, Wen; Zhang, Siwen; Huang, Kunkun; Yuan, Dan

    2017-10-01

    An ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in both positive and negative ion modes was established in order to comprehensively investigate the major constituents in Wu Ji Bai Feng Pill. Briefly, a Waters ACQUITY UPLC HSS C 18 column was used to separate the aqueous extract of Wu Ji Bai Feng Pill. A total of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid v/v were used as the mobile phase. All analytes were determined using quadrupole time-of-flight mass spectrometry with electrospray ionization source in positive and negative ion modes. At length, a total of 173 components including flavones and their glycosides, monoterpene glycosides, triterpene saponins, phenethylalchohol glycosides, iridoid glycosides, phthalides, tanshinones, phenolic acids, sesquiterpenoids and cyclopeptides were identified or tentatively characterized in Wu Ji Bai Feng Pill in an analysis of 16.0 min based on the accurate mass and tandem mass spectrometry behaviors. The developed method is rapid and highly sensitive to characterize the chemical constituents of Wu Ji Bai Feng Pill, which could not only be used for chemical standardization and quality control of Wu Ji Bai Feng Pill, but also be helpful for further study in vivo metabolism of Wu Ji Bai Feng Pill. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Enzymatic characterization and gene identification of aconitate isomerase, an enzyme involved in assimilation of trans-aconitic acid, from Pseudomonas sp. WU-0701.

    Science.gov (United States)

    Yuhara, Kahori; Yonehara, Hiromi; Hattori, Takasumi; Kobayashi, Keiichi; Kirimura, Kohtaro

    2015-11-01

    trans-Aconitic acid is an unsaturated organic acid that is present in some plants such as soybean and wheat; however, it remains unclear how trans-aconitic acid is degraded and/or assimilated by living cells in nature. From soil, we isolated Pseudomonas sp. WU-0701 assimilating trans-aconitic acid as a sole carbon source. In the cell-free extract of Pseudomonas sp. WU-0701, aconitate isomerase (AI; EC 5.3.3.7) activity was detected. Therefore, it seems likely that strain Pseudomonas sp. WU-0701 converts trans-aconitic acid to cis-aconitic acid with AI, and assimilates this via the tricarboxylic acid cycle. For the characterization of AI from Pseudomonas sp. WU-0701, we performed purification, determination of enzymatic properties and gene identification of AI. The molecular mass of AI purified from cell-free extract was estimated to be ~ 25 kDa by both SDS/PAGE and gel filtration analyses, indicating that AI is a monomeric enzyme. The optimal pH and temperature of purified AI for the reaction were 6.0 °C and 37 °C, respectively. The gene ais encoding AI was cloned on the basis of the N-terminal amino acid sequence of the protein, and Southern blot analysis revealed that only one copy of ais is located on the bacterial genome. The gene ais contains an ORF of 786 bp, encoding a polypeptide of 262 amino acids, including the N-terminal 22 amino acids as a putative periplasm-targeting signal peptide. It is noteworthy that the amino acid sequence of AI shows 90% and 74% identity with molybdenum ABC transporter substrate-binding proteins of Pseudomonas psychrotolerans and Xanthomonas albilineans, respectively. This is the first report on purification to homogeneity, characterization and gene identification of AI. The nucleotide sequence of ais described in this article is available in the DDBJ/EMBL/GenBank nucleotide sequence databases under the Accession No. LC010980. © 2015 FEBS.

  4. Overexpression of the NADP+-specific isocitrate dehydrogenase gene (icdA) in citric acid-producing Aspergillus niger WU-2223L.

    Science.gov (United States)

    Kobayashi, Keiichi; Hattori, Takasumi; Hayashi, Rie; Kirimura, Kohtaro

    2014-01-01

    In the tricarboxylic acid (TCA) cycle, NADP(+)-specific isocitrate dehydrogenase (NADP(+)-ICDH) catalyzes oxidative decarboxylation of isocitric acid to form α-ketoglutaric acid with NADP(+) as a cofactor. We constructed an NADP(+)-ICDH gene (icdA)-overexpressing strain (OPI-1) using Aspergillus niger WU-2223L as a host and examined the effects of increase in NADP(+)-ICDH activity on citric acid production. Under citric acid-producing conditions with glucose as the carbon source, the amounts of citric acid produced and glucose consumed by OPI-1 for the 12-d cultivation period decreased by 18.7 and 10.5%, respectively, compared with those by WU-2223L. These results indicate that the amount of citric acid produced by A. niger can be altered with the NADP(+)-ICDH activity. Therefore, NADP(+)-ICDH is an important regulator of citric acid production in the TCA cycle of A. niger. Thus, we propose that the icdA gene is a potentially valuable tool for modulating citric acid production by metabolic engineering.

  5. Wu-Chia-Pi Solution Attenuates Carbon Tetrachloride-Induced Hepatic Injury through the Antioxidative Abilities of Its Components Acteoside and Quercetin

    Directory of Open Access Journals (Sweden)

    Ching-Chiung Wang

    2012-12-01

    Full Text Available Wu-Chia-Pi medicated wine, composed nine Chinese medicines soaked in 35% alcohol, is widely used in Asia for its health-promoting functions. However, long-term consumption of alcohol could result in liver dysfunction. In this study, Wu-Chia-Pi solution (WCPS and extract (WCPE were prepared by modification of the principals given by the Committee on Chinese Medicine and Pharmacy in Taiwan. The aim of this study was to explore the protective effect of WCPS against carbon tetrachloride (CCl4-induced liver injury and to clarify its active component(s. Antioxidative effects of the test samples were evaluated via MDA inhibition, catalase activity and DPPH-scavenging assays. HPLC was used to analysis the active components. Results showed that WCPS (1 and 5 mL/kg significantly prevented CCl4-induced liver injury without chronic liver toxicity. Referring to the antioxidative activities, WCPE displayed significant MDA inhibitory and DPPH-scavenging activities with IC50 values of 0.91 ± 0.03 and 0.60 ± 0.04 mg/mL, respectively. Catalase activity was also enhanced by treatment of WCPE, acteoside and quercetin. Therefore, we suggest that acteoside and quercetin are the major contributors to the antioxidative and hepatoprotective activities of WCPS, and a possible mechanism could be mediated through reduction of oxidative stress.

  6. Tentative characterization of precursor compounds and co-factors of pigment formation in production of 'wu mi' from Vaccinium bracteatum Thunb. Leaves.

    Science.gov (United States)

    Fan, Mingcong; Fan, Yihui; Huang, Weiping; Wang, Li; Li, Yan; Qian, Haifeng; Zhang, Hui; Qi, Xiguang

    2018-10-01

    Vaccinium bracteatum leaves (VBTL) are traditionally used in China to dye rice grains, which assume a deep blue color, named 'Wu mi'. Information on the mechanism of pigment formation is limited. In this study, CIELAB color space parameters were used to represent the color of 'Wu mi'. Precursor compounds of pigments formed during the dyeing process were identified by UPLC Q-TOF MS analysis. The changes in co-factors for pigment formation in VBTL were measured at different growth stages. The L ∗ and b ∗ values of dyed rice increased as the leaves aged, whereas a ∗ values showed irregular changes. Six compounds were tentatively identified as pigment precursors by UPLC Q-TOF MS analysis. The pH and β-glucosidase activity at different growth stages of VBTL were indicated to be crucial co-factors for pigment formation. A tentative hypothesis is presented that iridoid glycosides are hydrolyzed by acids and β-glucosidases to form a dialdehyde structure that binds covalently with amino residues of lysine side chains in rice protein molecules. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Efficacy of MaZiRenWan, a Chinese Herbal Medicine, in Patients With Functional Constipation in a Randomized Controlled Trial.

    Science.gov (United States)

    Zhong, Linda Ld; Cheng, Chung-Wah; Kun, Wai; Dai, Liang; Hu, Dong-Dong; Ning, Zi-Wan; Xiao, Hai-Tao; Lin, Cheng-Yuan; Zhao, Ling; Huang, Tao; Tian, Ke; Chan, King-Hong; Lam, Ting-Wa; Chen, Xiao-Rui; Wong, Chi-Tak; Li, Min; Lu, Ai-Ping; Wu, Justin Cy; Bian, Zhao-Xiang

    2018-04-11

    The Chinese herbal medicine, MaZiRenWan (MZRW), has been used for more than 2000 years to treat constipation, but it has not been tested in a randomized controlled trial. We performed a trial to evaluate the efficacy and safety of MZRW, compared with the stimulant laxative senna or placebo, for patients with functional constipation (FC). We performed a double-blind, double-dummy, trial of 291 patients with FC based on Rome III criteria, seen at 8 clinics in Hong Kong from June 2013 through August 2015. Patients were observed for 2 weeks and then assigned randomly (1:1:1) to groups given MZRW (7.5 g, twice daily), senna (15 mg daily), or placebo for 8 weeks. Patients were then followed for 8 weeks and evaluated at baseline and weeks 4, 8 (end of treatment), and 16 (end of follow up). Participants recorded information on stool form and frequency, feeling of complete evacuation, and research medication taken. Data on individual bowel symptoms, global symptom improvement, and adverse events were collected. A complete response was defined as an increase ≥1 complete spontaneous bowel movement (CSBM)/week from baseline (the primary outcome). Secondary outcomes included response during the follow-up period, colonic transit, individual and global symptom assessments, quality of life measured with 36-item short form Chinese version, and adverse events. Although there was no statistically significant difference in proportions of patients with a complete response to MZRW (68%) vs. senna (57.7%) (P=.14) at week 8, there was a statistically significant difference vs. placebo (33.0%) (P<.005). At the 16-week timepoint (after the 8-week follow-up period), 47.4% of patients had a complete response to MZRW, 20.6% had a complete response to senna, and 17.5% had a complete response to placebo (P<.005 for MZRW vs. placebo). The group that received MZRW group also had significant increases in colonic transit and reduced severity of constipation, straining, incomplete evacuation, and

  8. Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.

    Science.gov (United States)

    Liu, Li; Ma, Hongyue; Tang, Yuping; Chen, Wenxing; Lu, Yin; Guo, Jianming; Duan, Jin-Ao

    2012-01-01

    The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions, the estrogen-like activity of 22 compounds was above 60% in 20 μg mL(-1). Furthermore, theoretical affinity of these compounds was certificated using the functional virtual screen of ER-α modulators by FlexX-Pharm. The accuracy of functional virtual screening of ER-α modulators could reach to 77.27%. The results showed that some compounds, such as organic acids and flavones in SWT series decoctions could be used as selective estrogen receptor modulators (SERMs) and could be selected for further development as potential agents for estrogen related diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Datu bāzes struktūras un datu tranformācija no relāciju datu bāzes uz NoSQL datu bāzi

    OpenAIRE

    Jērāne, Austra

    2013-01-01

    Bakalaura darbā „Datu bāzes struktūras un datu tranformācija no relāciju datu bāzes uz NoSQL datu bāzi” ir apkopota informācija par relāciju datu bāzu un NoSQL datu bāzu īpašībām un uz šī pētījuma pamata ir veikta dokumentu vadības sistēmas datu bāzes daļas tranformācija uz NoSQL datu bāzi.

  10. Structural and Biochemical Characterization of BdsA from Bacillus subtilis WU-S2B, a Key Enzyme in the “4S” Desulfurization Pathway

    Directory of Open Access Journals (Sweden)

    Tiantian Su

    2018-02-01

    Full Text Available Dibenzothiophene (DBT and their derivatives, accounting for the major part of the sulfur components in crude oil, make one of the most significant pollution sources. The DBT sulfone monooxygenase BdsA, one of the key enzymes in the “4S” desulfurization pathway, catalyzes the oxidation of DBT sulfone to 2′-hydroxybiphenyl 2-sulfonic acid (HBPSi. Here, we determined the crystal structure of BdsA from Bacillus subtilis WU-S2B, at the resolution of 2.2 Å, and the structure of the BdsA-FMN complex at 2.4 Å. BdsA and the BdsA-FMN complex exist as tetramers. DBT sulfone was placed into the active site by molecular docking. Seven residues (Phe12, His20, Phe56, Phe246, Val248, His316, and Val372 are found to be involved in the binding of DBT sulfone. The importance of these residues is supported by the study of the catalytic activity of the active site variants. Structural analysis and enzyme activity assay confirmed the importance of the right position and orientation of FMN and DBT sulfone, as well as the involvement of Ser139 as a nucleophile in catalysis. This work combined with our previous structure of DszC provides a systematic structural basis for the development of engineered desulfurization enzymes with higher efficiency and stability.

  11. The complete mitochondrial genome of the styloperlid stonefly species Styloperla spinicercia Wu (Insecta: Plecoptera) with family-level phylogenetic analyses of the Pteronarcyoidea.

    Science.gov (United States)

    Wang, Ying; Cao, Jinjun; Li, Weihai

    2017-03-13

    We present the complete mitochondrial (mt) genome sequence of the stonefly, Styloperla spinicercia Wu, 1935 (Plecoptera: Styloperlidae), the type species of the genus Styloperla and the first complete mt genome for the family Styloperlidae. The genome is circular, 16,129 base pairs long, has an A+T content of 70.7%, and contains 37 genes including the large and small ribosomal RNA (rRNA) subunits, 13 protein coding genes (PCGs), 22 tRNA genes and a large non-coding region (CR). All of the PCGs use the standard initiation codon ATN except ND1 and ND5, which start with TTG and GTG. Twelve of the PCGs stop with conventional terminal codons TAA and TAG, except ND5 which shows an incomplete terminator signal T. All tRNAs have the classic clover-leaf structures with the dihydrouridine (DHU) arm of tRNASer(AGN) forming a simple loop. Secondary structures of the two ribosomal RNAs are presented with reference to previous models. The structural elements and the variable numbers of tandem repeats are described within the control region. Phylogenetic analyses using both Bayesian (BI) and Maximum Likelihood (ML) methods support the previous hypotheses regarding family level relationships within the Pteronarcyoidea. The genetic distance calculated based on 13 PCGs and two rRNAs between Styloperla sp. and S. spinicercia is provided and interspecific divergence is discussed.

  12. Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts.

    Science.gov (United States)

    Wu, Chi-Ming; Chen, Po-Chun; Li, Te-Mao; Fong, Yi-Chin; Tang, Chih-Hsin

    2013-10-24

    Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is widely used for the treatment of gynopathies diseases such as menstrual discomfort, climacteric syndrome, dysmenorrhea, and other estrogen-related diseases. Recent studies have shown that SWT can treat primary dysmenorrhea, have anti-pruritic anti-inflammatory effects, and protect against radiation-induced bone marrow damage in an animal model. It has been reported that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption. However, the effect of SWT on bone cell function has not yet been reported. Alkaline phosphatase (ALP), bone morphogenetic proteins (BMP)-2, and osteopontin (OPN) mRNA expression was analyzed by qPCR. The mechanism of action of SWT extract was investigated using western blotting. The in vivo anti-osteoporotic effect of SWT extract was assessed in ovariectomized mice. Here, we report that SWT increases ALP, BMP-2, and OPN expression as well as bone mineralization. In addition, we show that the PI3K, Akt, and NF-κB signaling pathways may be involved in the SWT-mediated increase in gene expression and bone mineralization. Notably, treatment of mice with SWT extract prevented bone loss induced by ovariectomy in vivo. SWT may be used to stimulate bone formation for the treatment of osteoporosis.

  13. Identification of Multiple Ingredients for a Traditional Chinese Medicine Preparation (Bu-yang-huan-wu-tang by Liquid Chromatography Coupled with Tandem Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Tung-Hu Tsai

    2013-09-01

    Full Text Available Bu-yang-huan-wu-tang (BYHWT is a popular Traditional Chinese Medicine formula consisting of seven herbal medicines (Astragalus membranaceus, Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Carthamus tinctorius, Amygdalus persica and Pheretima aspergillum, that has been used in China for centuries to overcome stroke-induced disability. To ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass spectrometry (LC-MS/MS method for quantitative analysis of the major constituents in BYHWT. The herbal ingredients consisting of the cycloartane-type triterpene glycosides of astragaloside I, astragaloside II and astragaloside IV; isoflavones of formononetin, ononin calycosin, calycosin-7-O-β-d-glucoside; ligustilide and paeoniflorin were separated on a C18 column with gradient elution of methanol/10 mM ammonium acetate buffer–formic acid (100:0.1, v/v. This study was performed by a mass spectrometer using electrospray ionization (ESI with positive ionization ions monitored in the multiple reaction-monitoring (MRM mode. The linearity, accuracy, precision, limit of detection (LOD and lower limit of quantification (LLOQ were validated for this quantification method, and the sensitivity, reliability and reproducibility were all confirmed. The experiments provided a good method for analyzing BYHWT extracts. This study also quantitated the active components in various brands of commercially available products. The results indicated that the pharmaceutical industrial products of BYHWT exhibited considerable variation in their contents of the herbal compounds.

  14. Contamination and Human Health Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Oysters After the Wu Yi San Oil Spill in Korea.

    Science.gov (United States)

    Loh, Andrew; Yim, Un Hyuk; Ha, Sung Yong; An, Joon Geon; Kim, Moonkoo

    2017-07-01

    After the collision of the Singapore-registered oil tanker M/V Wu Yi San into the oil terminal of Yeosu, Korea on January 31, 2014, approximately 900 m 3 of oil and oil mixture were released from the ruptured pipelines. The oil affected more than 10 km of coastline along Gwangyang Bay. Emergency oil spill responses recovered bulk oil at sea and cleaned up the stranded oil on shore. As part of an emergency environmental impact assessment, region-wide monitoring of oil contamination in oyster had been conducted for 2 months. Highly elevated concentrations of polycyclic aromatic hydrocarbons (PAHs) were detected at most of the spill affected sites. Four days after the spill, the levels of PAHs in oysters increased dramatically to 627-81,000 ng/g, the average of which was 20 times higher than those found before the spill (321-4040 ng/g). The level of PAHs in these oysters increased until 10 days after the spill and then decreased. Due to the strong tidal current and easterly winter winds, the eastern part of the Bay-the Namhae region-was heavily contaminated compared with other regions. The accumulation and depuration of spilled oil in oyster corresponded with the duration and intensity of the cleanup activities, which is the first field observation in oil spill cases. Human health risk assessments showed that benzo[a]pyrene equivalent concentrations exceeded levels of concern in the highly contaminated sites, even 60 days after the spill.

  15. Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Zheng, Zhijie; Yan, Tongmeng; Chen, Weiying; Ye, Ling; Tang, Lan; Liu, Zhongqiu

    2012-08-01

    A rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry method was developed and validated for the determination and quantification of ephedrine in rat plasma samples. An Acquity UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) was used for chromatographic separation. Electrospray ionization in the positive mode was used, and the precursor-fragment ion pairs of m/z 166/148 and m/z 289/97 were adopted to characterize ephedrine and testosterone (internal standard), respectively. The method was validated using 10, 100 and 500 ng/mL of ephedrine. It demonstrated adequate levels of precision and accuracy, matrix effect, extraction recovery and stability. Linearity over the concentration range of 0.5-2000 ng/mL was acceptable with a correlation coefficient (r²) better than 0.990. To determine the pharmacokinetic behaviour of this sympathomimetic compound in the Sprague-Dawley rats, ephedrine hydrochloride, Herba Ephedrae single-herb and Wu Tou Tang decoctions were administered orally, and ephedrine hydrochloride was also administered by intravenous injection, and blood samples were collected over 24 h. Ephedrine was measured in plasma and pharmacokinetic parameters were determined by using the standard non-compartmental method and calculated by using Practical Pharmacokinetic Program-Version 87/97. The AUC(0-t) and T(max) values were significantly different (p Tang decoction compared to the other oral treatments, suggesting that some components in the decoction may reduce the bioavailability of ephedrine.

  16. Inhibition of Neoplastic Transformation and Chemically-Induced Skin Hyperplasia in Mice by Traditional Chinese Medicinal Formula Si-Wu-Tang

    Directory of Open Access Journals (Sweden)

    Mandy M. Liu

    2017-03-01

    Full Text Available Exploring traditional medicines may lead to the development of low-cost and non-toxic cancer preventive agents. Si-Wu-Tang (SWT, comprising the combination of four herbs, Rehmanniae, Angelica, Chuanxiong, and Paeoniae, is one of the most popular traditional Chinese medicines for women’s diseases. In our previous studies, the antioxidant Nrf2 pathways were strongly induced by SWT in vitro and in vivo. Since Nrf2 activation has been associated with anticarcinogenic effects, the purpose of this study is to evaluate SWT’s activity of cancer prevention. In the Ames test, SWT demonstrated an antimutagenic activity against mutagenicity induced by the chemical carcinogen 7,12-dimethylbenz(aanthracene (DMBA. In JB6 P+ cells, a non-cancerous murine epidermal model for studying tumor promotion, SWT inhibited epidermal growth factor (EGF-induced neoplastic transformation. The luciferase reporter gene assays demonstrated that SWT suppressed EGF-induced AP-1 and TNF-α-induced NF-κB activation, which are essential factors involved in skin carcinogenesis. In a DMBA-induced skin hyperplasia assay in ‘Sensitivity to Carcinogenesis’ (SENCAR mice, both topical and oral SWT inhibited DMBA-induced epidermal hyperplasia, expression of the proliferation marker Proliferating cell nuclear antigen (PCNA, and H-ras mutations. These findings demonstrate, for the first time, that SWT prevents tumor promoter and chemical-induced carcinogenesis in vitro and in vivo, partly by inhibiting DNA damage and blocking the activation of AP-1 and NF-κB.

  17. Dzimtes diskurss sporta žurnālistikā: Eiropas čempionātu basketbolā reprezentāciju Latvijas interneta ziņu portālos "Delfi" un "Tvnet" analīze (2008–2013) 

    OpenAIRE

    Ērmiņa, Evisa

    2014-01-01

    Maģistra darbā „Dzimtes diskurss sporta žurnālistikā: Eiropas čempionātu basketbolā reprezentāciju Latvijas interneta ziņu portālos "Delfi" un "Tvnet" analīze (2008-2013)” ir apskatītas Latvijas vīriešu un sieviešu basketbola izlases reprezentācijas Eiropas čempionātu laikā no 2008. līdz 2013. gadam (no maija līdz oktobrim) interneta ziņu portālos „Delfi” un „Tvnet”. Darba teorētiskā daļa satur atziņas par reprezentāciju, sociālās realitātes konstruēšanu, mediju ietekmi uz realitāti un ide...

  18. Studium tepelných vlastností materiálů akumulujících teplo na bázi fázové přeměny

    OpenAIRE

    Valentová, Kateřina

    2016-01-01

    Diplomová práce se zabývá studiem tepelných vlastností materiálů akumulující teplo na bázi fázové přeměny. Cílem této práce bylo proměřit tepelné vlastnosti materiálů využívající k akumulaci tepla fázovou přeměnu, a to především komerčního materiálu od firmy Phase Change Material Products Ltd pod názvem PlusICE A118. Takové materiály se označují jako PCM (z angl. Phase Change Material) a využívají se například jako tepelné akumulátory (izolanty) ve stavebnictví. Nejprve byly popsány fázové př...

  19. Ziştovi ve Yaş Antlaşması Arasında Tuna Kıyısında Bir Osmanlı Kenti: Silistre (1791–1793 The Danube Coast Between The Treaty Of Ziştovi And Yaş An Ottoman City: Silistra (1791 – 1793

    Directory of Open Access Journals (Sweden)

    Hava SELÇUK

    2013-07-01

    ınınkarşılanmasında( zahire, peksimet, silah vs önemli bir fonksiyonasahipti. Bu çalışmada kaynak olarak iki antlaşma arasında kadılartarafından tutulan 50 Numaralı Şer’iyye Sicili (1791-1793kullanılmıştır. 50 Numaralı Şer’iyye Sicili Ziştovi ve Yaş Antlaşmasıöncesi ve bu antlaşmalar sonrası Silistre’nin siyasi, sosyal, ekonomik veaskeri meselelerine ışık tutacak bilgiler ihtiva etmektedir. Şer’iyyeSicilleri, Osmanlı toplumunun siyasî, iktisadî, hukukî ve içtimaîdurumlarının ortaya çıkarılmasında önemli kaynaklardır. BulgaristanArşivi “Nationale Biblioteque” de bulunan 50 Numaralı Silistre Şer’iyyeSicili çalışmamızın ana kaynağını oluşturmaktadır. Söz konusudefterde miras davaları, aile, görevli tayinleri, gemi yapımı, elçilik, vergi(zahire, duhan, adat-ı ağnam vb. konuların yer aldığı iktisadî, askerî veiçtimaî olayları içeren iki yüz otuz üç belge bulunmaktadır. Askerikonulara ışık tutacak konulardaki ferman, emir, buyruldular şer’iyyesicillerine kayıt edilmiştir. Eşkıyalık, zahirenin gemilerle taşınması,ihtida (din değiştirme, tanassur ve Nemçe esirleri konularıincelenmiştir. Silistre’nin 1791–1793 yıllarına ait sicil kayıtlarındanhareketle bölgenin toplumsal hayatı ortaya konulmuştur.

  20. Wu Shangshi: One of the outstanding founders of Chinese modern geography%吴尚时对中国近代地理学的贡献与学术思想探讨

    Institute of Scientific and Technical Information of China (English)

    陈吉余; 吴超羽; 司徒尚纪

    2017-01-01

    Wu Shangshi (1904-1947) is considered one of the outstanding modem geographers emerging in the early 20th century in China.It is partly a result of the introduction of modem sciences from the West.Wu graduated as a gold medalist in Sun Yat-sen University (SYU) in 1928.He was then granted scholarship to study geography in France.He studied at the University of Lyon and the University of Grenoble under the supervision of A.Allix,M.Pardé and R.Blanchard,who was one of the best known students of V.de la Blanche.In 1934,Wu finished his study in France and returned to SYU to serve as a professor of geography.He was head of the department in 1939-1945,the most difficult and perilous period during the Japanese invasion.The university moved constantly to flee the flames of war.The thousands of miles across south and south-west China became Wu's research field.To continue one's work under such circumstances required an extraordinary determination and dedication to science.Excessive hard work in tough environments ruined his health.Wu died in 1947 at the age of 43.Among the second generation of Chinese modem geographers,Wu was a rare example of an integrated geographer.He combined comprehensive and complex geographic thought with a balanced approach between holistic perspective and detailed research.In addition,he possessed an outstanding ability to conduct field work.As such,many of his research findings have withstood the test of time and remain relevant to this day.For instance,Wu proposed "one belt and three arcs" to summarize the distribution of the mountain ranges in China.On the long debates of the stratigraphic sequence of the red bed formations "Danxia" and "Nanxiong",Wu suggested an alternative viewpoint that the two formations could be deposited at approximately the same time but in different faces and it has been confirmed by modem geologic investigation some 50 years later.Both contributions were listed on the "Great Geographical Discoveries of China in 100

  1. Globalization, Polanyi, and the Chinese Yuan

    Science.gov (United States)

    2007-12-01

    Archive/2004/Sep/23-184387.html (accessed June 12, 2007). 99 ŖND LD: APEC Finance Chiefs Paper over Forex Flexibility Issue," Kyodo News...2006). ŖND LD: APEC Finance Chiefs Paper Over Forex Flexibility Issue." Kyodo News International, Inc. and The Gale Group. http://findarticles.com

  2. Molecular diversity analysis of Tetradium ruticarpum (WuZhuYu) in China based on inter-primer binding site (iPBS) markers and inter-simple sequence repeat (ISSR) markers.

    Science.gov (United States)

    Xu, Jing-Yuan; Zhu, Yan; Yi, Ze; Wu, Gang; Xie, Guo-Yong; Qin, Min-Jian

    2018-01-01

    "Wu zhu yu", which is obtained from the dried unripe fruits of Tetradium ruticarpum (A. Jussieu) T. G. Hartley, has been used as a traditional Chinese medicine for treatment of headaches, abdominal colic, and hypertension for thousands of years. The present study was designed to assess the molecular genetic diversity among 25 collected accessions of T. ruticarpum (Wu zhu yu in Chinese) from different areas of China, based on inter-primer binding site (iPBS) markers and inter-simple sequence repeat (ISSR) markers. Thirteen ISSR primers generated 151 amplification bands, of which 130 were polymorphic. Out of 165 bands that were amplified using 10 iPBS primers, 152 were polymorphic. The iPBS markers displayed a higher proportion of polymorphic loci (PPL = 92.5%) than the ISSR markers (PPL = 84.9%). The results showed that T. ruticarpum possessed high loci polymorphism and genetic differentiation occurred in this plant. The combined data of iPBS and ISSR markers scored on 25 accessions produced five clusters that approximately matched the geographic distribution of the species. The results indicated that both iPBS and ISSR markers were reliable and effective tools for analyzing the genetic diversity in T. ruticarpum. Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  3. 赤凤逢源针刺手法治疗踝关节扭伤的研究%Study on the Chi Feng Feng Yuan manipulation of acupuncture in the treatment of ankle joint sprain

    Institute of Scientific and Technical Information of China (English)

    史莹莺

    2015-01-01

    目的:探讨赤凤逢源针刺手法治疗急性踝关节扭伤的临床疗效。方法:收治急性踝关节扭伤患者132例,按就诊顺序随机分为3组,针刺组44例,采用“赤凤逢源”法针刺治疗;教学组44例,参照《针灸学》治疗踝关节扭伤方法;扶他林组44例,采用扶他林乳剂外擦治疗。观察治疗后患者踝关节疼痛、肿胀及功能改善情况,并对3组患者治疗前、后踝关节症状评分进行比较。结果:3组患者治疗前后症状评分差值比较:①疼痛差值:针刺组2.59(0.92),教学组1.86(0.51),扶他林组1.5(0.876),F=21.669,P=0;肿胀差值:针刺组2.09(0.603),教学组2.09(0.96),扶他林组1.45(0.901),F=8.496,P=0;功能障碍:针刺组:2.14(1.091),教学组2.09(0.96),扶他林组1.77(0.642),F=2.053,P=0.133;总分差值:针刺组6.82(1.632),教学组6.18(1.968),扶他林组4.73(1.37),F=18.021,P=0。止痛效果针刺组疗效优于教学组更优于扶他林组(P1*2=0,P1*3=0,P2*3=0),肿胀疗效针刺组与教学组差不多但都优于扶他林组(P1*2=1.000,P1*3=0.001,P2*3=0.001),关节功能障碍疗效三组差别不大(P=0.133)。从总的疗效来看,针刺组与教学组疗效相近(P1*2=0.180),但均优于扶他林组(P1*2=0.18,P1*3=0.000,P2*3=0.000)。结论:赤凤逢源针刺手法治疗踝关节扭伤,能起到良好的活血止痛效果,值得临床推广应用。%Objective:To investigate the clinical curative effect of Chi Feng Feng Yuan acupuncture in the treatment of acute ankle sprain.Methods:132 patients with acute ankle joint sprain were selected.They were randomly divided into 3 groups according to the order of treatment.44 cases in the acupuncture group were given "Chi Feng Fegn Yuan" acupuncture therapy;the teaching group with 44 cases refered to the methods of "acupuncture" in the treatment of ankle joint sprain;the voltaren group with 44 cases were given votalin

  4. 滋水清肝饮联合针刺法治疗儿童抽动障碍的临床研究%Clinical research on Zi Shui Qing Gan Decoction combined with acupuncture treatment for tic disorder in children

    Institute of Scientific and Technical Information of China (English)

    殷二航

    2016-01-01

    Objective:To explore the clinical effect of Zi Shui Qing Gan Decoction combined with acupuncture treatment for tic disorder in children.Methods:64 children with tic disorder were selected.They were randomly divided into the control group and the observation group with 32 cases in each.The patients in the control group were treated with acupuncture,while the patients in the observation group were treated with Zi Shui Qing Gan Decoction combined with acupuncture treatment.We compared the clinical efficacy of the two groups.Results:The effective rate of observation group of 93.8%was significantly higher than 78.1%in the control group(P < 0.05).Conclusion:The clinical effect of Zi Shui Qing Gan Decoction combined with acupuncture treatment for tic disorder in children was significant.%目的:探讨滋水清肝饮联合针刺法治疗儿童抽动障碍的临床疗效。方法:收治儿童抽动障碍患儿64例,随机分为对照组和观察组各32例,对照组采用针刺法治疗,观察组采用滋水清肝饮联合针刺法治疗,比较两组临床疗效。结果:观察组治疗有效率93.8%,明显高于对照组的78.1%(P<0.05)。治疗后,与对照组相比,观察组的YGTSS评分显著降低(P<0.05)。结论:滋水清肝饮联合针刺法治疗儿童抽动障碍的临床疗效显著。

  5. Un imaginaire dévoilé/déphasé. Stratégies narratives et mémoire culturelle dans le roman 54 des Wu Ming

    Directory of Open Access Journals (Sweden)

    Matteo Martelli

    2015-02-01

    Full Text Available This essay analyses the narrative strategies through which cultural memory is portrayed in 54, a novel in which Wu Ming (a collective of four Italian fiction writers suggests a literary mapping of the Fifties. This is obtained by a recovery of a shared imaginary tradition which is close to the reader, mixing fictional and historical characters, films, books, different genres of popular literature. Nevertheless, the rewriting of these imaginary traditions involves their displacement, a presentation which is constantly created from an unusual point of view. Thus, shifting the image of what is already known, the text inquires into several modalities of a questioning about cultural memory and its redefinition in relation to contemporary culture. By focusing on these elements, this study proposes an analysis which starts from the construction of the characters, the role of suspense and the adoption of multiple traditions of novel writing.

  6. Determination of blood concentrations of main active compounds in Zi-Cao-Cheng-Qi decoction and their total plasma protein binding rates based on hollow fiber liquid phase microextraction coupled with high performance liquid chromatography.

    Science.gov (United States)

    Li, Miaomiao; Chen, Xuan; Hu, Shuang; Wang, Runqin; Peng, Xiaoli; Bai, Xiaohong

    2018-01-01

    Oil-in-salt hollow fiber liquid phase microextraction coupled with high performance liquid chromatography ultraviolet detection (HPLC-UV) was developed for determination of the blood concentrations of the main active compounds, hesperidin, honokiol, shikonin, magnolol, emodin and β,β'-dimethylacrylshikonin, after oral administration of Zi-Cao-Cheng-Qi decoction (ZCCQD) and their total plasma protein binding rates. In the procedure, a hollow fiber segment was immersed in organic solvent to fill the solvent in the fiber lumen and wall pore, and then the fiber was immersed into sodium chloride solution to cover a thin salt membrane on the fiber wall pore filling organic solvent. Various factors affecting the procedure, such as extraction solvent, sample phase pH, stirring rate, extraction time, NaCl concentration and fiber immersion time in the NaCl solution, were optimized. Under the optimum conditions, good linearities (r 2 ≥0.9905), low limits of detection (0.7-2.5ng/mL) or quantitation (1.2-12ng/mL), satisfactory precision (2.6%-12.8%) and accuracy (81.0%-114.2%) of this method, were observed. The results showed that, after oral administration of a 25g/kg dose, (1) the blood concentrations (at 0.5h) of hesperidin, honokiol, shikonin, magnolol, emodin and β,β'-dimethylacrylshikonin were 0.45, 0.40, 0.48, 0.74, 0.11 and 1.11μg/mL, respectively; (2) the total plasma protein binding rates of the six active compounds were 42.0% (hesperidin), 71.8% (honokiol), 64.6% (shikonin), 77.7% (magnolol), 75.3% (emodin) and 75.7% (β,β'-dimethylacrylshikonin), respectively. The proposed procedure coupled with HPLC shows obvious advantages, such as low solvent consumption, simple operation, high sensitivity and strong purifying and can be used for the determination of both the blood concentrations and total plasma protein binding rates of active compounds in traditional Chinese medicine. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics.

    Science.gov (United States)

    Liu, Pei; Li, Zhenhao; Qian, Dawei; Li, Wei; Shang, Er-Xin; Duan, Jin-Ao

    2013-06-15

    A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of the three main bioactive compounds, i.e., ligustilide, dehydrocostuslactone and α-cyperone in dog plasma after oral administration of the essential oil of Xiang-Fu-Si-Wu Formula (XEO). Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mLmin(-1), using 0.1% formic acid-acetonitrile as mobile phase. The MS/MS ion transit ions monitored were 190.5→90.9 for ligustilide, 231.1→185.1 for dehydrocostuslactone, 219.2→123.0 for α-cyperone and 748.5→158.1 for IS. Method validation was performed as per Food and Drug Administration guidelines and the results met the acceptance criteria. The lower limit of quantification (LLOQ) achieved was 5.12ng/mL for ligustilide, 1.06ng/mL for dehydrocostuslactone and 1.89ng/mL for α-cyperone, respectively, and the calibration curves obtained were linear (r>0.99) over the concentration range approximately 1-1000ng/mL. The intra- and inter-day precision was less than 15% and the accuracy was within ±9.2%. After validation, this method was successfully applied to a pharmacokinetic study where dogs were orally given 0.3g/kg XEO, equivalent to 183.6mg/kg of ligustilide, 5.0mg/kg of dehydrocostuslactone and 26.2mg/kg of α-cyperone, respectively. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. DNA damage and decrease of cellular oxidase activity in piglet ...

    African Journals Online (AJOL)

    DNA damage and decrease of cellular oxidase activity in piglet sertoli cells exposed to gossypol. Ming Zhang, Hui Yuan, Zuping He, Liyun Yuan, Jine Yi, Sijun Deng, Li Zhu, Chengzhi Guo, Yin Lu, Jing Wu, Lixin Wen, Qiang Wei, Liqun Xue ...

  9. Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang-Fu-Si-Wu Decoction effective fraction in normal and dysmenorrheal symptom rats.

    Science.gov (United States)

    Liu, Pei; Li, Wei; Li, Zhen-hao; Qian, Da-wei; Guo, Jian-ming; Shang, Er-xin; Su, Shu-lan; Tang, Yu-ping; Duan, Jin-ao

    2014-07-03

    Xiang-Fu-Si-Wu Decoction (XFSWD) has been widely used to treat primary dysmenorrhea in clinical practice for hundreds of years and shown great efficacy. One fraction of XFSWD, which was an elution product by macroporous adsorption resin from aqueous extract solution with 60% ethanol (XFSWE), showed great analgesic effect. The present study was conducted to investigate the possible pharmacokinetic and tissue distribution profiles of four major bioactive constituents (berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine) after oral administration of XFSWE in dysmenorrheal symptom rats, and to compare the difference between normal and dysmenorrheal symptom rats. Estradiol benzoate and oxytocin were used to produce dysmenorrheal symptom rat model. The experimental period was seven days. At the final day of experimental period, both normal and dysmenorrheal symptom rats were orally administrated with XFSWE, and then the blood and tissues samples were collected at different time points. Berberine, protopine, tetrahydrocoptisine and tetrahydropalmatine in blood and tissue samples were determined by LC-MS/MS. Pharmacokinetic parameters were calculated from the plasma concentration-time data using non-compartmental methods. The differences of pharmacokinetic parameters among groups were tested by one-way analysis of variance (ANOVA). There were statistically significant differences (Pnormal and dysmenorrheal symptom rats that orally administered with same dosage of XFSWE. In tissue distribution study, the results showed that the overall trend was C(Spleen)>C(Liver)>C(Kidney)>C(Uterus)>C(Heart)>C(Lung)>C(Ovary)>C(Brain)>C(Thymus), C(M-60 min)>C(M-120 min)>C(M-30 min)>C(C-60 min)>C(C-120 min)>C(C-30 min). The contents of protopine in liver, spleen and uterus were more than that in other tissues of dysmenorrheal symptom rats. Compared to normal rats, partial contents of the compounds in dysmenorrheal symptom rats׳ tissues at different time points had significant

  10. Zhu Qing Wang

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Zhu Qing Wang. Articles written in Journal of Chemical Sciences. Volume 121 Issue 4 July 2009 pp 543-548. Highly sensitive optical chemosensor for the detection of Cu using a rhodamine B spirolatam · Gen Hua Wu Dong Xiang Wang Da Yu Wu Yuan Gao Zhu Qing Wang.

  11. Implications of Chinese Yuan on China’s competitiveness

    OpenAIRE

    Uddin, Md Akther; Baddou, Mehdi; Gulzar Mohd, Rosana

    2015-01-01

    The stability and level of strength or weakness in exchange rates are prime considerations of monetary authorities and businesses, both domestic and international. This paper thus analyses the RMB’s appreciation and depreciation against its major trading partners’ currencies namely the USD, EUR, JPY, AUD and MYR. It also includes a review of their volatilities and most importantly, the economic implications of the RMB rates on exports and foreign investment flows. The Renminbi has come a long...

  12. Quality Assessment of Biodiesels from Lophira Lanceolata and Zi

    African Journals Online (AJOL)

    M.KYARI

    The purpose of this study was to produce and characterize biodiesels obtained from seeds of ... of biodiesel is very low as compared to fossil ... Sangere town in Adamawa and Maiduguri ... round bottom flask and pre-heated at .... rapeseed and soybean oils, indicating the oils ... storage; high level of unsaturated fatty acid.

  13. Classification of Ap-stars HR 830 and ZI CVn

    International Nuclear Information System (INIS)

    Zverko, J.

    1984-01-01

    Two ambiguously classified Ap-stars, HR 830 and 21 CVn, are studied. The observational data are compared with the data for normal stars αDel and αLyr. Star HR 830 is classified as Ap of type Si based on the enhanced absorption in the Si lines and photometric variability in UBV. 21 CVn is classified as Ap Si based on weaker absorption of helium, the variability of helium lines, photometric periodic variability and the properties of the UV spectrum. It is concluded that the photometric periodic variability is a good indicator of Ap-properties of rapidly rotating A and late B stars. (author)

  14. The distribution of QSO redshift (1 + Zi)/(1 + Zj)

    International Nuclear Information System (INIS)

    Drew, J.E.

    1978-01-01

    Following a general survey conducted by Burbidge and Burbidge (1975) to consider the case for line-Locking in QSO spectra and a later statistical study by Sargent and Boroson (1977), the method of the latter and the QSO sample of the former are investigated further. The results of Sargent and Boroson are confirmed and it is noted that uneven spectral resolution in the QSO sample has over-emphasized the 1.11 peak in the combined emission-absorption and absorption-absorption redshift ratio distribution. The sample is extended to include recently observed QSOs and the absorption redshift selection is designed to exclude all but the most certain absorption redshifts. Care is taken in the selection procedure to ensure that there is no personal bias either way regarding the line-locking hypothesis. A peak is found to occur in the distribution of (1 + sub(Zem))/(1 + sub(Zabs)), given by the extended sample, at 1.11 with a chance probability of 3 x 10 -5 . It is concluded that the present data suggests the peak is real and that a physical interaction between the QSO emission line regions and absorption systems concerned is required to explain its occurrence. However, the nature of the interaction is as yet unknown and there are difficulties with the possibility of line-locking. (orig.) [de

  15. Diagrams for certain quotients of PSL(2,Z[i])

    Indian Academy of Sciences (India)

    in their action on the complex plane. PSL(2, Z) is a Fuchsian group, 1 is discontinuous in C and therefore has no Fuchsian subgroups [2] of finite index. As with PSL (2, Z) and the other Euclidean Bianchi groups, many properties of 1 depends on its decomposition as a non-trivial amalgam. Real interest in Picard and Bianchi ...

  16. The influence of hallux valgus on pelvis and lower extremity movement during gait [Vliv valgózní deformity palce na pohyb pánve a dolních končetin při chůzi

    Directory of Open Access Journals (Sweden)

    Miloslav Klugar

    2011-12-01

    Full Text Available BACKGROUND: The hallux and the first metatarsophalangeal joint play a major role in load transmission during walking. OBJECTIVE: The main aim of this study was to investigate differences in kinematics of the pelvis and lower extremities during gait by comparing people with hallux valgus (HV and a control group (CG. METHODS: We compared subjects with asymptomatic bilateral HV (n = 6, 57.8 ± 5.64 years with those who had CG (n = 11, 50.7 ± 4.41 years. Gait analysis was investigated using an optoelectronic system Vicon MX. The subjects walked at self-selected speeds. In total, five trials of each subject were analyzed. The statistical processing was performed by means of the Student t-test. The effect size was determined using the ω2 measure. RESULTS: In people with HV there was a significantly smaller maximum of dorsal flexion during the stance phase (p 0.06 and a greater maximum of plantar flexion at the beginning of the stance phase (p 0.06. The maximum of knee extension at the end of the swing phase was significantly greater (p 0.06 in subjects with HV. In the frontal plane, a significantly smaller maximum of hip abduction (p 0.06 during the gait cycle was observed in people with HV. The range of the pelvic obliquity (p 0.06 and the pelvic rotation (p 0.06 were significantly smaller in people with HV. CONCLUSION: This study demonstrated that HV does not exclusively concern the foot. The valgus deformity of the big toe can negatively influence function of the lower extremities and can cause overloading of those segments as well.[VÝCHODISKA: Palec a I. metatarzofalangeální kloub hrají klíčovou úlohu v přenosu zatížení při chůzi. CÍLE: Účelem této studie bylo analyzovat a interpretovat rozdíly v kinematických parametrech chůze u osob s hallux valgus v porovnání s kontrolní skupinou. METODIKA: Porovnávali jsme osoby s asymptomatickou oboustrannou valgózní deformitou palce (n = 6; 57,8 ± 5,64 let s kontrolní skupinou

  17. Hydrothermal synthesis of porous Co(OH)2 nanoflake array film and ...

    Indian Academy of Sciences (India)

    sented discharge current and M (mg), V (V) and t (s) designate mass of ..... Chang Z R, Li H J, Tang H W, Yuan X Z and Wang H J 2009 Int. J. Hydrogen. Energy ... Interfaces 3 99. Kong L B, Liu M C, Lang J W, Liu M, Luo Y C and Kang L 2011 ... Yuan Y F, Xia X H, Wu J B, Yang J L, Chen Y B and Guo S Y 2011. Electrochim.

  18. The Frontier National Society Viewed by WU Luzhen:Case of East Simeng Survey in Inner Mongolia%吴禄贞视野中的边疆民族社会①--以内蒙古东四盟调查为例

    Institute of Scientific and Technical Information of China (English)

    王鹏辉

    2015-01-01

    Inner Mongolia Dongsimeng region formed Mongolian and Han mixed pattern of survival in Qing Dynasty, and formed an in-terdependent community of destiny. WU lu-zhen survey showing the internal crisis of Inner Mongolia Dongsimeng borderland ethnic society, involving many aspects,such as politics, livelihoods and economies, religion and customs, which showed its domestic policy and internation-al aggression interaction mechanism of social contradictions and resulted in the frontier ethnic society in Modern China.%有清一代,内蒙古东四盟地域已经形成蒙汉杂居的生存格局,并且结成相互依存的命运共同体。吴禄贞的调查呈现出内蒙古东四盟边疆民族社会的内在危机,涉及政治、生计与经济、宗教与风俗诸多方面,显现其国内新政与国际侵略互动的社会矛盾机制。内蒙古东四盟身处清末国内国际两种交冲的力量与历史传统的碰撞,逐渐生成中国近代的边疆民族社会。

  19. Trénink ve výškovém prostředí a jeho vliv na změny ve vybraných fyziologických ukazatelích reprezentantů Slovenské republiky v závodní chůzi Training in high altitude environments and its influence on the changes in selected physiological indicators of a Slovak Republic representative in walking

    Directory of Open Access Journals (Sweden)

    Martin Pupiš

    2005-02-01

    Full Text Available Příprava ve střední a vysoké nadmořské výšce je dlouhodobou součástí přípravy slovenských reprezentantů v závodní chůzi. Martin Pupiš je jedním z těch atletů, kteří pravidelně využívají tento systém. V tomto příspěvku popisujeme jeho přípravu ve čtyřech vysokohorských kempech v přípravných fázích v letech 1998/1999–2001/2002. Části roku, ve kterých se kempy odehrávaly, byly velmi podobné. Doba trvání byla rovněž stejná od 26 do 36 dnů. Průměrné množství závodní chůze a běhu bylo v rámci jednoho dne přibližně stejné během všech čtyř kempů. Poměr závodní chůze v kilometrech se zvýšil ze 70% na 80%. Podíl oblastí pro chůzi se měnil v závislosti na aktuální specializaci s nejvyšším počtem kilometrů ve vytrvalosti tempa. Reakce na přípravu ve vyšší nadmořské výšce byla velmi dobrá; když jsme analyzovali krevní složky – hematokrit, hemoglobin, erytocyty, střední množství erytocytů – zaznamenali jsme pozitivní změny; pouze u leukocytů nastal pokles. Middle and high altitude preparation is a longterm part of the preparation of our Slovak race walking representatives. Martin Pupiš is one of those athletes whose regularly makes use of this system. In our paper we report his preparation at four high altitude camps, in preparation phases in the years 1998/99–2001/02. The period of the year when the camps took place were very similar. Also the duration was from 26 days to 36 days. The average amount of racewalking and running was, for one day, approximately the same during all four camps. The proportion of race walking in kilometres increased from 70% to 80%. The proportion of walking zones changed depending on the current specialisation with the highest number of km in tempo endurance. The reaction to high altitude preparation was very good, when in analysed blood components – hematocrit, haemoglobin, erythrocytes, and a medium quantity

  20. SYNTHESES, STRUCTURES AND PROPERTIES Jian Wu1*, Fu

    African Journals Online (AJOL)

    Preferred Customer

    Printed in Ethiopia. © 2014 Chemical Society of Ethiopia ... 1Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi University ... The O–H···O and C–H···Cl hydrogen-bonding interactions play a significant role in.

  1. Supply chain management in selected clothing retail businesses / Jianling Wu

    OpenAIRE

    Wu, Jianling

    2004-01-01

    In today's highly competitive, global market place the pressure on organizations to find new ways to create and deliver value to customers grows ever strong. At the same time, market maturity combined with new sources of global competition has led to over-capacity in many industries leading to an inevitable pressure on price. Managers are increasingly interested in actively managing their supply chains because of environmental changes. The study is aimed to identify the importa...

  2. 对格里埃尔《声乐协奏曲》的两种演唱诠释---吴碧霞与德赛演唱的《声乐协奏曲》之比较%Interpretation of Two Types of Singing Performance of Gliere's"Vocal Concerto":A Comparison of"Vocal Con-certo"Sung by Wu Bixia and Natalie Dessay

    Institute of Scientific and Technical Information of China (English)

    张艳

    2015-01-01

    吴碧霞被誉为“中西合璧”的夜莺,无论在美声唱法还是民族唱法领域都有一定的造诣,演唱的歌曲都有丰富的表现力与感染力。纳塔利·德赛同样也被誉为20世纪末的“声音奇迹”,两个来自不同国度的歌唱家在演绎这首《声乐协奏曲》时,也有着不同的演唱风格与音响效果。通过对吴碧霞与德赛演唱的这首《声乐协奏曲》的比较分析,让我们更加清楚地认识到我国声乐发展的前景,并对两种风格的演唱进行文化的理解与思考。%Wu Bixia is hailed as a "nightingale" integrating the East and the West, as she has certain attainments in both bel canto and nazionale cantanti, and the songs sung by her are all highly expressive and attractive. Natalie Dessay is honored as a"vocal marvel" at the end of the 20th century. The two singers from two different countries have different singing styles and vo-cal effects when they sing"Vocal Concerto". Through a compara-tive analysis on"Vocal Concerto"sung by Wu Bixia and Natalie Dessay, we can more clearly learn about the prospect of the de-velopment of vocal music in China, thus understanding and re-flecting more about the cultures of the two styles.

  3. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Ping Chen1 2 Qing-Sheng Wu1 Ya-Ping Ding3 Pin-Shi Yuan1. Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China; Department of Chemistry, Chizhou College, Chizhou, Anhui 247000, P.R. China; Department of Chemistry, Shanghai University, Shanghai 200436, P.R. China ...

  4. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Yu-Song Guo Zhong-Duo Wang Cheng-Zhong Yan Yu-Lan Zhang Jin-Nan Zheng Yuan-Min Xu Tao Du Chu-Wu Liu · More Details Fulltext PDF ... Aifu Yang Dapeng Sun Shikai Liu Ying Dong Zhong Chen Zunchun Zhou · More Details Fulltext ...

  5. Geochemical characteristics of Mesoproterozoic metabasite dykes ...

    Indian Academy of Sciences (India)

    High Mg# observed in a number of samples indicates their derivation from .... show characteristic of orangeites, lamproites or ail- ... ite, and iron oxides. .... while preparing powder for the chemical analy- ses. ..... Cai K, Sun M, Yuan C, Zhao G, Xiao W, Long X and Wu .... Mallik A K, Gupta S N and Ray Barman T 1991 Dating.

  6. Genetic diversity of bitter taste receptor gene family in Sichuan

    Indian Academy of Sciences (India)

    Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations. YUAN SU DIYAN LI UMA GAUR YAN WANG NAN WU BINLONG CHEN HONGXIAN XU HUADONG YIN YAODONG HU QING ZHU. RESEARCH ARTICLE Volume 95 Issue 3 September 2016 pp 675-681 ...

  7. Fulltext PDF

    Indian Academy of Sciences (India)

    The paper “Anaerobic oxidation of methane in coastal sediment from Guishan Island. (Pearl River Estuary), South China Sea” by Zijun Wu, Huaiyang Zhou, Xiaotong Peng,. Nan Jia, Yuhong Wang and Linxi Yuan (Journal of Earth System Science, Volume 117,. No. 6, pages 935–944, December 2008) overlaps in scope and ...

  8. Percutaneous kyphoplasty combined with zoledronic acid infusion in the treatment of osteoporotic thoracolumbar fractures in the elderly

    OpenAIRE

    Shi,Chen; Zhang,Mi; Cheng,An-Yuan; Huang,Zi-Feng

    2018-01-01

    Chen Shi,1,* Mi Zhang,2,* An-Yuan Cheng,1 Zi-Feng Huang1 1Department of Trauma Surgery, Wuhan No 1 Hospital, Wuhan, China; 2Department of Orthopedics, Wuhan No 5 Hospital, Wuhan, China *These authors contributed equally to this work Objective: We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures...

  9. Percutaneous kyphoplasty combined with zoledronic acid infusion in the treatment of osteoporotic thoracolumbar fractures in the elderly

    OpenAIRE

    Shi C; Zhang M; Cheng AY; Huang ZF

    2018-01-01

    Chen Shi,1,* Mi Zhang,2,* An-Yuan Cheng,1 Zi-Feng Huang1 1Department of Trauma Surgery, Wuhan No 1 Hospital, Wuhan, China; 2Department of Orthopedics, Wuhan No 5 Hospital, Wuhan, China *These authors contributed equally to this work Objective: We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OV...

  10. Ground Deformation Detection Using China’s ZY-3 Stereo Imagery in an Opencast Mining Area

    OpenAIRE

    Wenmin Hu; Lixin Wu; Wei Zhang; Bin Liu; Jiaxing Xu

    2017-01-01

    Detection and extraction of mining-induced ground deformation can be used to understand the deformation process and space distribution and to estimate the deformation laws and trends. This study focuses on the application of ground deformation detection and extraction combined with digital surface model (DSM), derived from China’s ZiYuan-3 (ZY-3) satellite stereo imagery and the advanced spaceborne thermal emission and reflection radiometer global digital elevation model (ASTER GDEM) data. A ...

  11. [Hemothorax caused by primary pleural chondrosarcoma: a case report and review of literatureYuan].

    Science.gov (United States)

    Yuan, Y Q; Zhu, L Y; Zeng, H H; Zhou, R; Chen, P

    2016-11-12

    Objective: To analyze the clinical features of one case of spontaneous hemothorax caused by primary pleural chondrosarcoma and therefore to improve the understanding of this disease. Methods: The clinical features of a case with primary pleural chondrosarcoma were analyzed retrospectively and the related literatures were reviewed.The literature review was carried out with "primary pleural, chondrosarcoma" in Chinese and English respectively, as the search terms in Wanfang Data, CNKI and PubMed database from January 1980 to October 2015. A total of 6 articales, 1 in Chinese and 5 in English, were reviewed. Results: A 29 year-old male patient was admitted to the hospital because of fever, chest tightness, shortness of breath for 20 days. CT scan of the chest showed a mass near the right posterior fourth rib and right pleural effusion.Routine examination of the pleural effusion confirmed the presence of hemothorax. Thoracotomy was performed and revealed hemothorax in the right thorax, and a mass near the pleural apex. The tumor was removed by surgery and pleural decortication was also performed. Pathology study confirmed the diagnosis of high-differentiated chondrosarcoma. The patient was followed and there was no recurrence until now. A total of 6 case reports were retrieved from Wanfang Data, CNKI and PubMed. Five cases had complete data, including 2 males and 3 females(age from 28 to70), and another (a 78-year old male) without adequate data. Conclusions: Primary pleural chondrosarcoma is a rare disease, and hemothorax as the first manifestation is even rare. It is easily to be misdiagnosed due to nonspecific clinical symptoms.The final diagnosis depends ultimately on pathological biopsy. Thoracotomy is the most effective method for treatment of primary pleural chondrosarcoma.

  12. Yuan and Jing Afr J Tradit Complement Altern Med. (2011) 8(2):104 ...

    African Journals Online (AJOL)

    USER

    kinase C, which participates in ischemic neuron injury, and plays an important role in the ... pharmaceutical effects including two-way regulations of blood glucose and immunologic ..... positive cell-cycle regulating agent (Feng et al., 2008a).

  13. Wandering saints : Chan eccentrics in the art and culture of Song and Yuan China

    NARCIS (Netherlands)

    Paul, Paramita

    2009-01-01

    In Chinese history, few personalities compare to the Chan eccentrics. These legendary, exceptional monks, including the friends Hanshan and Shide, their teacher Fenggan, and Budai, supposedly dwelled in the mountains and cities of southeast China between the seventh and tenth centuries. Dressed in

  14. Yu šien yuan cha dzu czha t šia lie kutí

    Czech Academy of Sciences Publication Activity Database

    Chen, W.; Křížek, Michal

    2009-01-01

    Roč. 39, č. 15 (2009), s. 159-194 ISSN 1000-0984 R&D Projects: GA AV ČR(CZ) IAA100190803 Institutional research plan: CEZ:AV0Z10190503 Keywords : uniform partition * superconvergence * Céa's lemma Subject RIV: BA - General Mathematics

  15. The Yuan vs. the Dollar: China and the United States are Already in a Hot War

    Science.gov (United States)

    2005-05-19

    HotWar is named as such because it is a money-centric conflict where speculative money (Le., "Hof’ money in FOREX )reigns as an instrument of economic and...exchange ( FOREX ) market. Here, the USD valiantly attempts to defend its reserved position in the world, while it is dragged into collisions with the...the two nations; rather, the value ofthese two currencies, which perennially draw speculative (i.e., "hot") money in the FOREX markets, is the

  16. The Yuan vs. the Dollar: China and the United States are Already in a "Hot" War

    National Research Council Canada - National Science Library

    Daly, William R

    2005-01-01

    ...., "Hot" money in FOREX) reigns as an instrument of economic and financial power. Ironically, just as the Cold War symbolically ended with the fall of the Berlin Wall, this Hot War began with another fall...

  17. Dongfeng has fixed a sales goal of 80 billion yuan supported by Nissan

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    <正> The Nissan and Dongfeng Group-based Dongfeng Automobile Co., Ltd, which has the largest investment in the history of the industry, opened officially for business on July 1. With a total investment of USD 2 billion and 70,000 employees, the company is the first joint venture in China which plans a full range of truck, light commercial and passenger vehicles. According to president Nakamura, the company has established a management

  18. VizieR Online Data Catalog: High-mass starless clump candidates from ATLASGAL (Yuan+, 2017)

    Science.gov (United States)

    Yuan, J.; Wu, Y.; Ellingsen, S. P.; Evans, N. J., II; Henkel, C.; Wang, K.; Liu, H.-L.; Liu, T.; Li, J.-Z.; Zavagno, A.

    2017-08-01

    This work is based on data from several Galactic plane surveys covering wavelengths from mid-IR to submillimeter. The sample of dense clumps from the ATLASGAL survey (Schuller+ 2009A&A...504..415S) provides the basis for our investigation. The ATLASGAL survey mapped 420 square degrees of the Galactic plane between -80°MIPS) surveys have been used to identify possible young stellar object (YSO) candidates associated with ATLASGAL clumps. Far-IR data from the Hi-GAL survey (Herschel-PACS and -SPIRE) have been used to further constrain the starless clump candidates and investigate their dust properties. (2 data files).

  19. China currency dispute: is a rise in the yuan inevitable, necessary or desirable?

    OpenAIRE

    Tatom, John

    2007-01-01

    China-bashing has become a popular media and political sport. This is largely due to the U.S. trade imbalance and the belief, by some, that China is responsible for it because it manipulates its currency to hold down the dollar prices of its goods, unfairly creating a trade advantage that has contributed to the loss of U.S. businesses and jobs. This paper reviews the problem of the large trade imbalance that the United States has with China and its relationship to Chinese exchange rate poli...

  20. China Currency Dispute: Is a Rise in the Yuan Necessary, Inevitable or Desirable?

    OpenAIRE

    John A. Tatom

    2007-01-01

    China-bashing has become a popular media and political sport. This is largely due to the U.S. trade imbalance and the belief, by some, that China is responsible for it because it manipulates its currency to hold down the dollar prices of its goods, unfairly creating a trade advantage that has contributed to the loss of U.S. businesses and jobs. This paper reviews the problem of the large trade imbalance that the United States has with China and its relationship to Chinese exchange rate policy...

  1. Studies on Anti-Hepatoma Effect of Gan-Ai-Xiao Decoction | Yuan ...

    African Journals Online (AJOL)

    Purpose: To explore the anti-hepatoma effect of Gan-Ai-Xiao Decoction (GAXD), a folk remedy. Methods: High performance liquid chromatography (HPLC) was used to identify the major chemical components of GAXD ethanol extract (EE). The cytotoxic effect of GAXD EE against HepG2 cells was measured by methyl ...

  2. VizieR Online Data Catalog: Galaxy clusters: radio halos, relics and parameters (Yuan+, 2015)

    Science.gov (United States)

    Yuan, Z. S.; Han, J. L.; Wen, Z. L.

    2017-10-01

    A large number of radio halos, relics, and mini-halos have been discovered and measured in recent decades through observations with VLA (e.g., Giovannini & Feretti 2000NewA....5..335G; van Weeren et al. 2011A&A...533A..35V), GMRT (e.g., Venturi et al. 2007A&A...463..937V; Kale et al. 2015A&A...579A..92K), WSRT (e.g., van Weeren et al. 2010Sci...330..347V; Trasatti et al. 2015A&A...575A..45T), and also ATCA (e.g., Shimwell et al. 2014MNRAS.440.2901S, 2015MNRAS.449.1486S). We have checked the radio images of radio halos, relics, and mini-halos in the literature and collected in Table 1 the radio flux Sν at frequencies within a few per cent around 1.4 GHz, 610 MHz, and 325 MHz; we have interpolated the flux at an intermediate frequency if measurements are available at higher and lower frequencies. To establish reliable scaling relations, we include only the very firm detection of diffuse radio emission in galaxy clusters, and omit questionable detections or flux estimates due to problematic point-source subtraction. (3 data files).

  3. Yuan et al., Afr J Tradit Complement Altern Med. (2014) 11(4):120 ...

    African Journals Online (AJOL)

    cadewumi

    Conclusions: Izalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promising lead ... For the therapy of overactive bladder syndrome, many drugs such as anti-muscarinic agents have exhibited significant clinical benefits ... Figure 1: Chemical structure of izalpinin.

  4. 'Pays' -'Land'-'Yuan Lin'. The power of landscape (architecture) terms

    NARCIS (Netherlands)

    Bruns, D.; Brink, van den A.

    2012-01-01

    In order to continue building a common body of knowledge, landscape architecture researchers and practitioners must refer to the same fundamental concepts – particularly in those instances where different words are used to describe them. This paper puts the focus on ‘landscape’, probably the most

  5. Euros vs. yuan: comparing European and Chinese fishing access in West Africa.

    Directory of Open Access Journals (Sweden)

    Dyhia Belhabib

    Full Text Available We compare the performance of European Union (EU and Chinese fisheries access agreements with West African countries in terms of illegal and unreported fishing, economic equity, and patterns of exploitation. Bottom-up re-estimations of catch reveal that the EU (1.6 million t•year(-1 and China (2.3 million t•year(-1 report only 29% and 8%, respectively, of their estimated total catches (including estimated discards whenever possible from West African countries between 2000 and 2010. EU catches are declining, while Chinese catches are increasing and are yet to reach the historic maximum level of EU catches (3 million t•year(-1 on average in the 1970s-1980s. The monetary value of EU fishing agreements, correlated in theory with reported catches, is straightforward to access, in contrast to Chinese agreements. However, once quantified, the value of Chinese agreements is readily traceable within the African economy through the different projects they directly cover, in contrast to the funds disbursed [to host governments] by the EU. Overall, China provides resources equivalent to about 4% of the ex-vessel value [value at landing] of the catch taken by Chinese distant-water fleets from West African waters, while the EU pays 8%. We address the difficulties of separating fees directly related to fishing from other economic or political motivations for Chinese fees, which could introduce a bias to the present findings as this operation is not performed for EU access fees officially related to fishing. Our study reveals that the EU and China perform similarly in terms of illegal fishing, patterns of exploitation and sustainability of resource use, while under-reporting by the EU increases and that by China decreases. The EU agreements provide, in theory, room for improving scientific research, monitoring and surveillance, suggesting a better performance than for Chinese agreements, but the end-use of the EU funds are more difficult, and sometime impossible to ascertain.

  6. Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-? for infantile hemangioma

    OpenAIRE

    Zhang, Ling; Wu, Hai Wei; Yuan, Weien; Zheng, Jia Wei

    2017-01-01

    Ling Zhang,1 Hai Wei Wu,1 Weien Yuan,2 Jia Wei Zheng1 1Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Background: Infantile hemangiomas (IHs) are the most common benign vascular tumor of infancy. They occur more frequently in female infants....

  7. Preparation of ZiO2 specimens for transmission electron microscopy

    International Nuclear Information System (INIS)

    Bressiani, A.H.A.

    1987-01-01

    The determination of average grain size, of the presence of monoclinic, tetragonal and cubic phases, as well as their relative distributions are necessary for the study of several partially stabilized zirconia properties. However, the phase distributions can be changed during the preparation of specimens for transmission electron microscopy, yielding misleading results. In this work suitable preparation method is reported. (Author) [pt

  8. Konstrukce chemosenzorů na bázi cyklodextrinů

    Czech Academy of Sciences Publication Activity Database

    Hezký, Petr; Jindřich, J.

    2009-01-01

    Roč. 103, č. 11 (2009), s. 951-952 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /44./. 27.11.2009-29.11.2009, Liblice] Institutional research plan: CEZ:AV0Z40550506 Keywords : cyclodextrine * chemosensor Subject RIV: CC - Organic Chemistry

  9. Computational Thermodynamics of Materials Zi-Kui Liu and Yi Wang

    Energy Technology Data Exchange (ETDEWEB)

    Devanathan, Ram

    2017-02-01

    This authoritative volume introduces the reader to computational thermodynamics and the use of this approach to the design of material properties by tailoring the chemical composition. The text covers applications of this approach, introduces the relevant computational codes, and offers exercises at the end of each chapter. The book has nine chapters and two appendices that provide background material on computer codes. Chapter 1 covers the first and second laws of thermodynamics, introduces the spinodal as the limit of stability, and presents the Gibbs-Duhem equation. Chapter 2 focuses on the Gibbs energy function. Starting with a homogeneous system with a single phase, the authors proceed to phases with variable compositions, and polymer blends. The discussion includes the contributions of external electric and magnetic fields to the Gibbs energy. Chapter 3 deals with phase equilibria in heterogeneous systems, the Gibbs phase rule, and phase diagrams. Chapter 4 briefly covers experimental measurements of thermodynamic properties used as input for thermodynamic modeling by Calculation of Phase Diagrams (CALPHAD). Chapter 5 discusses the use of density functional theory to obtain thermochemical data and fill gaps where experimental data is missing. The reader is introduced to the Vienna Ab Initio Simulation Package (VASP) for density functional theory and the YPHON code for phonon calculations. Chapter 6 introduces the modeling of Gibbs energy of phases with the CALPHAD method. Chapter 7 deals with chemical reactions and the Ellingham diagram for metal-oxide systems and presents the calculation of the maximum reaction rate from equilibrium thermodynamics. Chapter 8 is devoted to electrochemical reactions and Pourbaix diagrams with application examples. Chapter 9 concludes this volume with the application of a model of multiple microstates to Ce and Fe3Pt. CALPHAD modeling is briefly discussed in the context of genomics of materials. The book introduces basic thermodynamic concepts clearly and directs readers to appropriate references for advanced concepts and details of software implementation. The list of references is quite comprehensive. The authors make liberal use of diagrams to illustrate key concepts. The two Appendices at the end discuss software requirements and the file structure, and present templates for special quasi-random structures. There is also a link to download pre-compiled binary files of the YPHON code for Linux or Microsoft Windows systems. The exercises at the end of the chapters assume that the reader has access to VASP, which is not freeware. Readers without access to this code can work on a limited number of exercises. However, results from other first principles codes can be organized in the YPHON format as explained in the Appendix. This book will serve as an excellent reference on computational thermodynamics and the exercises provided at the end of each chapter make it valuable as a graduate level textbook. Reviewer: Ram Devanathan is Acting Director of Earth Systems Science Division, Pacific Northwest National Laboratory, USA.

  10. Elucidation of mechanism of Si-jun-zi decoction-induced reversal of ...

    African Journals Online (AJOL)

    Methods: Spleen deficiency syndrome was induced in a rat model with reserpine. Liquid ... high-throughput quantification ability for ... HPLC grade acetonitrile was purchased from ..... study on the antitumor effect of flavonoid derivative 3d in.

  11. Sorbenty na bázi huminových látek a chitosanu

    Czech Academy of Sciences Publication Activity Database

    Havelcová, Martina; Mizera, Jiří; Machovič, V.; Přibyl, Oldřich; Borecká, Lenka; Krausová, Ivana

    2011-01-01

    Roč. 105, č. 12 (2011), s. 913-917 ISSN 0009-2770 R&D Projects: GA ČR GA106/09/0735 Institutional research plan: CEZ:AV0Z30460519; CEZ:AV0Z10480505 Keywords : humic substances * lignite * oxihumolite Subject RIV: DJ - Water Pollution ; Quality Impact factor: 0.529, year: 2011 http://www.chemicke-listy.cz/docs/full/2011_12_913-917.pdf

  12. Inbound marketing v provozní fázi webu

    OpenAIRE

    Váňa, Vojtěch

    2013-01-01

    The aim of the diploma thesis is the analysis of set inbound marketing components and suggestion of a strategical concept with the option of real processing of this web within the bounds of possibility of the set marketing components. In the theoretical part of the thesis, the whole strategy of inbound marketing and its general inbound marketing components are presented. In the practical part of the thesis, the analysis of the website magazine in connection with user behaviour is presented, i...

  13. LIMBA ROMÂNĂ DE ASTĂZI SI INFLUENŢA MEDIA (DAR NU NUMAI)

    OpenAIRE

    Dumitru TIUTIUCA

    2007-01-01

    The present paper reviews some specific phenomenafrequently considered to display ”negative” values, regarding the presenceof particular facts occurring in our contemporary Romanian language, someof them being determined and promoted by the powerful media influenceexerted within nowadays society. Actually, this kind of „paradigmaticchange”, which has been present also with the language domain, occurswithin the larger European and Postmodern milieu. The author’s premiseslie in the fundamental ...

  14. LIMBA ROMÂNĂ DE ASTĂZI SI INFLUENŢA MEDIA (DAR NU NUMAI

    Directory of Open Access Journals (Sweden)

    Dumitru TIUTIUCA

    2007-06-01

    Full Text Available The present paper reviews some specific phenomenafrequently considered to display ”negative” values, regarding the presenceof particular facts occurring in our contemporary Romanian language, someof them being determined and promoted by the powerful media influenceexerted within nowadays society. Actually, this kind of „paradigmaticchange”, which has been present also with the language domain, occurswithin the larger European and Postmodern milieu. The author’s premiseslie in the fundamental idea that language turns into a living organism andconsequently points out „the metamorphosis of living”: it is born, grows anddies, shows internal deformations, namely „the pathologies” called„language mistakes”, as well as various complexes and syndromes etc.Among these, there are brought into discussion the intricate issue ofRomanian language as of Latin origin, the acute offensive of Anglo-Saxon, Italian and Spanish neologisms, the contradictions occurred between their written and spoken forms, the persistence of „stereotype language” within structures, the pronunciation of foreign words, avoiding cacophonies, the aggression of the licentious and so on.

  15. Single-mode Laser by Parity-time Symmetry Breaking

    Science.gov (United States)

    2014-11-21

    solenoid -like Pds5B that reside in direct proximity to Wapl and the Smc3-Scc1 in- teraction interface (fig. S13), implying that Wapl and Pds5 control the...accepted 26 September 2014 10.1126/science.1256904 REPORTS ◥ OPTICS Single-mode laser by parity-time symmetry breaking Liang Feng,1* Zi Jing Wong,1...Ren-Min Ma,1* Yuan Wang,1,2 Xiang Zhang1,2† Effective manipulation of cavity resonant modes is crucial for emission control in laser physics and

  16. Wu et al., Afr J Tradit Complement Altern Med., (2018) 15 (1): 151 ...

    African Journals Online (AJOL)

    asdasd

    2017-12-29

    Dec 29, 2017 ... 1Department of Science and Technology and 2School of Biological Science and .... collected from Lu-mountain (Zibo, China) , and identified by the expert of plant taxonomy, Professor Shoujin FAN .... Biological Chemistry, 391, ... 21st century natural product research and drug development and traditional.

  17. Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China.

    Science.gov (United States)

    Zhu, Teng; Lu, Qing-Bin; Zhang, Shu-Yan; Wo, Ying; Zhuang, Lu; Zhang, Pan-He; Zhang, Xiao-Ai; Wei, Wei; Liu, Wei

    2017-05-01

    To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate. Altogether 122 (7.5%) of 1617 children found to be infected with WUPyV and 88 (72.1%) were coinfected with other viruses during 2012-2015. The phylogenetic analysis showed that 14 strains from our study formed two new clusters (Id and IIIc) within the Branch I and Branch III, respectively. WUPyV is persistently circulating in China. Surveillance on WUPyV infection in wider areas and long persistence is warranted.

  18. Reworked crustal of early Paleozoic WuYi Orogen revealed by receiver function data

    Science.gov (United States)

    Wei, Y.; Duan, Y.; Tian, X.; Zhao, Y.

    2017-12-01

    Intraplate orogenic belt, which occurs at the rigid and undeformable plate interiors, is a distinct new type of orogen rather than an interplate or plate marginal orogenic belt, whose deformation occurs exclusively at plate margins. Therefore, intraplate orogenic belts are the most obvious exception to the plate-tectonic paradigm, they are uncommon in Earth's history. The early Paleozoic Wuyi orogen in South China is one of the few examples of intraplate orogen, and is a key to understanding the process of intraplate orogenesis and global early Paleozoic geodynamics. In this study, we select teleseismic records from 45 mobile linear seismic stations deployed in Wuyi Mountain and 58 permanent stations setting in Jiangxi and Fujian provinces, from January 2011 to December 2012, and calculate the crustal thickness and average crustal Vp/Vs ratio using the H-κ stacking method. The main results include the following: 1) the crustal average Poission's ratio shows an increase tendency from land to sea, the interior of Wuyi orogen belt with an low ration less than 0.23, and the coastline with high ration which is up to 0.28, which indicate a very heterogeneous crustal structure and composition in Wuyi orogen and coast belt. 2) the crustal thickness ranges 28-34 km and shows a tendency of thinning from inland to coast in the region of SE China margin, which maight mean the eastern Eurasia lithospheric is extension and thinning induced by the subducted paleo-Pacific slab. To conclusion, we assume that Wuyi orogen experienced upper crustal thickening, lower crust and lithosphere delamination during the early Paleozoic orogeny, and lithosphere extension in Mesozoic. This research is founded by the Natural Science Foundation of China (41174052 and 41604048).

  19. Effect of Zhen-wu decoction on chronic heart failure in rats

    African Journals Online (AJOL)

    ... has been an increased hospitalization burden, and makes HF a global public health problem. The most effective and commonly used drugs for treatment of HF are angiotensin-converting enzyme (ACE) inhibitors, β-adrenoceptor blockers, and digitalis [5-7]. The American Heart. Association (AHA) and European Society of ...

  20. Selected Articles From Wu-Li T’Ung-Pao (Physics Bulletin) (Number 5, 1960)

    Science.gov (United States)

    1960-12-07

    seisstific research. W© had m©t eonstdsrabl© eueeeas.-’ Our ohe»ieal ®agi&®£>riag department had extracted’ rayos fsom the oomjs stock* Our...won. pi our ’diffusion process our *ch*in~^h.|tt~ X ^i"was.&böVO 85 percent and the saa responsible» for this iaehi&ic&l woxic vms only a high school

  1. and Jet Power/Emission in AGNs Zhongzu Wu1,∗ , Minfeng Gu2 ...

    Indian Academy of Sciences (India)

    Abstract. Neutral hydrogen (HI) 21-cm absorption has been detected against very powerful radio jets. In this paper, based on Gupta's sample. (Gupta et al. 2006), we present our preliminary study of the correlations between the HI column density N(HI) and the jet power, N(HI) versus the low frequency luminosity at 408 MHz, ...

  2. Effect of Zhen-wu decoction on chronic heart failure in rats | Liu ...

    African Journals Online (AJOL)

    Results: Compared with normal control group, ZWD group showed decreased arterial systolic pressure (SBP, 89.16 ± 17.27 mmHg), diastolic pressure (DBP, 72.54 ± 22.36 mmHg), mean arterial pressure (MAP, 72.64 ± 11.87 mmHg), heart rate (HR, 368.25 ± 39.12 beats/min), left ventricular systolic peak (LVSP, 105.27 ...

  3. Ignition delay time correlation of fuel blends based on Livengood-Wu description

    KAUST Repository

    Khaled, Fathi; Badra, Jihad; Farooq, Aamir

    2017-01-01

    observed for combustion phasing in homogeneous charge compression ignition (HCCI) predictions between simulations performed with detailed chemistry and calculations using the developed ignition delay correlation.

  4. Reviving ancient Chinese mathematics mathematics, history and politics in the work of Wu Wen-Tsun

    CERN Document Server

    Hudecek, Jiri

    2014-01-01

    Twentieth-century China has been caught between a desire to increase its wealth and power in line with other advanced nations, which, by implication, means copying their institutions, practices and values, whilst simultaneously seeking to preserve China's independence and historically formed identity. Over time, Chinese philosophers, writers, artists and politicians have all sought to reconcile these goals and this book shows how this search for a Chinese way penetrated even the most central, least contested area of modernity: science.Reviving Ancient Chinese Mathematics is a study of the life

  5. Moessbauer study of the firing technology of the moon-white Jun porcelain in Chinese Yuan Dynasty

    International Nuclear Information System (INIS)

    Chen Songhua

    1994-01-01

    The moon-white Jun porcelain glaze contains Fe 2 O 3 , Fe 3 O 4 and structural iron. The firing atmosphere of ancient Jun kilns was modestly reductive. The firing temperature was slightly above 1250 C. The glaze color appears moon-white, and is related to the low concentration of Fe 2+ . The coordination numbers of Fe 2+ and Fe 3+ are both 4. (orig.)

  6. His Excellency Professor Dr Che-Ho Wei, Chairman, National Science Council Executive Yuan, Republic of China

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Professor Dr. Che-Ho Wei signing the Guest Book with CERN Director-General, L. Maiani. Photo 02: Professor Dr. Che-Ho Wei. Photo 03::Professor Dr. Che-Ho Wei shaking hands with CERN Director-General, L. Maiani.

  7. Mössbauer study of the firing technology of the moon-white Jun porcelain in Chinese Yuan Dynasty

    Science.gov (United States)

    Songhua, Chen; Zhengyao, Gao; Zhongtian, Sun; Xiande, Chen

    1994-12-01

    The moon-white Jun porcelain glaze contains Fe2O3, Fe3O4 and structural iron. The firing atmosphere of ancient Jun kilns was modestly reductive. The firing temperature was slightly above 1250 ‡C. The glaze color appears moon-white, and is related to the low concentration of Fe2+. The coordination numbers of Fe2+ and Fe3+ are both 4.

  8. ZI-annual 1991. Annual for the brick and tile, structural ceramics and clay pipe industries. ZI-Jahrbuch 1991. Jahrbuch fuer die Ziegel-, Baukeramik- und Steinzeugroehren-Industrie

    Energy Technology Data Exchange (ETDEWEB)

    Schellbach, G [ed.

    1991-01-01

    This annual appearing in German and English gives information on important results of research development projects in Germany and the rest of Europe, and reports on technical innovations in plant and machinery for these industries. The content of the technical articles is concentrated on following main subjects: Drying of ceramic products, testing and improving the frost resistance of clay roofing tiles, improved static design and thermal insulation of brick structures. Subjects also dealt with in the field of environmental protection are fluorine binding and changes in the salts content of the brick/mortar system. (BWI).

  9. Obchodní vztahy ČR s Indonézií a jejich perspektivy

    OpenAIRE

    Pertl, Nikola

    2010-01-01

    This bachelor thesis analyses chronological development of business relations between the Czech Republic or Czechoslovakia and Indonesia, with focus on the period after World War I. The work should also inform about current state, opportunities and threats for the Czech trade with the fourth most populous country of the world. Last but not least, this thesis deals with the future prospects of the respective business relations, mainly based on primary research.

  10. SU iÇERiSiNDE AGIRLIGI DiKKATE ALINAN BiR KOLONUN BURKULMA ANALiZi

    Directory of Open Access Journals (Sweden)

    Yeliz PEKBEY

    2008-02-01

    Full Text Available EULER, 1744 yılında sabit enine kesitli çubukların kritik burkulma kuvvetlerini, çubuk agırlıgını ihmal ederek hesaplamıstır. Daha ekonomik çubuklar için, çubuk agırlıgının da dikkate alınması ve çözüm yapılması gerekir. Literatürde, 10 degisik mesnetleme durumu için çubuk agırlıgı da dikkate alınarak hava ortamında kritik burkulma kuvvetleri ve asimptotik burkulma kuvvetleri hesaplanmıs ve bu kuvvetlerden hareketle 4 mesnetleme durumu için sudaki kritik kuvvetlerin bulunabilecegi, diger 6 mesnetleme durumuna ait sudaki kritik burkulma kuvvetlerinin ise hava ortamındakinden hesaplanamayacagı belirtilmistir. Bu çalısmada, bugüne kadar kritik burkulma kuvvetleri hesaplanmamıs, su içerisinde, üst ucu ankastre mesnetli alt ucu ankastreli kayıcı mesnetli çubuk için çözüm verilmistir.

  11. LIMBII ROMÂNE DE ASTĂZI ŞI INFLUENŢA MEDIA (DAR NU NUMAI

    Directory of Open Access Journals (Sweden)

    Dumitru Tiutiuca

    2007-05-01

    Full Text Available The paper entitled Remarks on Contemporary Romanian Language reviews some specific phenomenafrequently considered to display „negative” values, regarding the presence of particular facts occurring in ourcontemporary Romanian language, some of them being determined and promoted by the powerful mediainfluence exerted within nowadays society. Actually, this kind of „paradigmatic change”, which has beenpresent also with the language domain, occurs within the larger European and Postmodern milieu. The author’spremises lie in the fundamental idea that language turns into a living organism and consequently points out „themetamorphosis of living”: it is born, grows and dies, shows internal deformations, namely „the pathologies”called „language mistakes”, as well as various complexes and syndromes etc. Among these, there are broughtinto discussion the intricate issue of Romanian language as of Latin origin, the acute offensive of Anglo-Saxon,Italian and Spanish neologisms, the contradictions occurred between their written and spoken forms, thepersistence of „stereotype language” within structures, the pronunciation of foreign words, avoidingcacophonies, the aggression of the licentious and so on.

  12. Internalisasi Nilai-nilai Multikultural dalam Tafsîr Al-Rāzi pada Pengembangan Pendekatan Pembelajaran Tafsir

    Directory of Open Access Journals (Sweden)

    M.Noor Hidayat

    2017-03-01

    Full Text Available  This article contains about study of multicultural values in the tafsîr Imām Fakhruddîn Al-Rāzî (Mafātîḥul Ghaib, which has different specification from other tafsir in the same era. It includes many arguments about theology and fiqh. Furthermore, the multicultural values in this tafsîr are implemented on the development approach of learning tafsîr. This study used library research with phenomenology approach by seeing the reality of tafsîr Imām Fakhruddîn Ar-Rāzî which is accepted and refered by many of firqah, besides tafsîr Maudhū’i is used tool to make the study of tafsir Imām Fakhruddîn Ar-Rāzî deeper. The result of this study consist of two parts: 1 An explanation of multicultural values concepts in tafsîr Mafātîḥul Ghaib, 2 Multicultural approach learning as the result of implementing multicultural values on learning approach.

  13. Strukturované produkty na bázi komodit a jejich ekonomický význam

    Directory of Open Access Journals (Sweden)

    Oldřich Rejnuš

    2014-03-01

    Full Text Available Purpose of the article: The article deals with issues of contemporary interconnecting of commodities market with financial investment instrument markets, with special regards to the influence of contemporary changes in commodities trading and creating individual sorts of structured products based on commodities. Considering the fact that mutual interconnections between commodities and financial investment instruments are not random, where, beside its theoretical interestingness, they have their insignificant economic importance, the aim of the article is to analyse contemporary utilization of individual sorts of commodity structured products both from the point of view of theoretical nature and, before all, their economic importance. In connection with it, reasons of contemporary spreading of synthetic financial derivative instruments derived from commodities, commodity stock exchange indexes or individually constructed, so called commodity baskets, are explored. And last but not least, it deals with a question whether this is just a temporary situation or continuation of the phenomenon can be supposed. Methodology/methods: The article deals with system analysis of relations between commodity underlying assets and individual sorts of structured products and analysis contemporary changes in ways how commodities are traded in stock exchanges; it is focused on how they influence creating structured products. Scientific aim: The aim of the research is to specify both positive and negative aspects of mutual interconnection of commodity instruments with individual structured products and to predict future development in this field with regards to possible influences on world economy. Findings: The article explains contemporary changes in the way how commodities are traded at world stock exchanges and it specifies both positive and negative influences of these changes on world economy. Conclusions: Based on accomplished analysis of connections between underlying commodity assets and individual sorts of structured products as well as contemporary changes of ways of commodities trading at stock exchange, internationally coordinated state regulation is recommended as well as stricter supervision of institutions working in this area.

  14. LIMBII ROMÂNE DE ASTĂZI ŞI INFLUENŢA MEDIA (DAR NU NUMAI)

    OpenAIRE

    Dumitru Tiutiuca

    2007-01-01

    The paper entitled Remarks on Contemporary Romanian Language reviews some specific phenomenafrequently considered to display „negative” values, regarding the presence of particular facts occurring in ourcontemporary Romanian language, some of them being determined and promoted by the powerful mediainfluence exerted within nowadays society. Actually, this kind of „paradigmatic change”, which has beenpresent also with the language domain, occurs within the larger European and Postmodern milieu....

  15. Power, identity and antiquarian approaches in modern Chinese art

    OpenAIRE

    Yang, Chia-Ling

    2014-01-01

    The pursuit of antiquity was important for scholarly artists in constructing their knowledge of history and cultural identity in late Imperial China. Following various publications by Bi Yuan 畢沅 (1730-1797), Wu Yi 武億 (1745-1799) and Qian Daxin 錢大昕 (1728-1804) in the 18th century, the study and collecting of rubbings of Northern Wei stone inscriptions and steles was popular. Such spread of interest in jinshi, inscriptions on metal and stone, also formed a base for studying seal carving, epigra...

  16. Factors of the HIV Transmission in Men Who Have Sex with Men in Suizhou City from 2009 to 2013

    Directory of Open Access Journals (Sweden)

    Fan Yang, MD

    2015-03-01

    Conclusions: HIV continues to spread rapidly among MSM in Suizhou City. The high-risk behavior among MSM remains a hindrance to HIV prevention. Innovative intervention approaches are essential for HIV surveillance and prevention among MSM in Suizhou City. Yang F, Shi X, He W, Wu S, Wang J, Zhao K, Yuan H, Martin K, and Zhang H. Factors of the HIV transmission in men who have sex with men in Suizhou City from 2009 to 2013. Sex Med 2015;3:24–31.

  17. 實徵研究/Information Literacy in the Workplace: A Cross-cultural Perspective/Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Yuhfen Diana Wu Yuhfen Diana Wu

    2012-04-01

    Full Text Available This cross-cultural study has two main purposes: to investigate how information literacy is perceived in the workplace and to discover how employees obtain information to carry out their jobs in an effective and timely fashion. This project applies a mix of research methods, including site visits, interviews, and a survey. More than 120 participants from forty companies were involved in this study. They were from a wide variety of industries in Taiwan and Silicon Valley, in Northern California, where many companies base offices or operations from around the world. Major obstacles in conducting cross-continent research are cost, time demands, scheduling, and adaptation to local culture. In this global economy, cross-cultural and cross-border research will help educators, such as librarians, understand the complexity of skills expected in the workplace. Much has been written on information literacy, yet very few can relate how information literacy is applied in the workplace. This primary study sheds some light to help academic librarians reposition themselves as researchers-educators integral to student success. 本論文為一跨文化性的研究,具有兩個主要目的:一是探討在職場中對於資訊素養的認知;二是探討員工如何及時有效的獲取和應用資訊來執行自己的任務。本研究採用混合式研究方法,包括實地考察、訪談和問卷調查。研究對象來自北加州矽谷和臺灣40家企業的120多名員工,他們分別從事不同行業。其中許多世界級的跨國企業選擇矽谷或臺灣作為公司總部或世界營運樞紐。進行跨洲研究的主要阻礙包括經費、時間、行程安排與適應當地的文化。跨文化和跨國界的研究將有助於教育工作者,如圖書館員,了解職場上所需技能的複雜性。目前已出版許多關於資訊素養的文獻,僅少涉及職場上資訊素養的應用。由於學術圖書館員在學生的學習過程中扮演不可或缺的角色,此初步研究,可幫助學術圖書館員重新為自己定位。 頁次:84-104

  18. A computational exploration of the McCoy-Tracy-Wu solutions of the third Painlevé equation

    Science.gov (United States)

    Fasondini, Marco; Fornberg, Bengt; Weideman, J. A. C.

    2018-01-01

    The method recently developed by the authors for the computation of the multivalued Painlevé transcendents on their Riemann surfaces (Fasondini et al., 2017) is used to explore families of solutions to the third Painlevé equation that were identified by McCoy et al. (1977) and which contain a pole-free sector. Limiting cases, in which the solutions are singular functions of the parameters, are also investigated and it is shown that a particular set of limiting solutions is expressible in terms of special functions. Solutions that are single-valued, logarithmically (infinitely) branched and algebraically branched, with any number of distinct sheets, are encountered. The algebraically branched solutions have multiple pole-free sectors on their Riemann surfaces that are accounted for by using asymptotic formulae and Bäcklund transformations.

  19. Geometric Potential Assessment for ZY3-02 Triple Linear Array Imagery

    Directory of Open Access Journals (Sweden)

    Kai Xu

    2017-06-01

    Full Text Available ZiYuan3-02 (ZY3-02 is the first remote sensing satellite for the development of China’s civil space infrastructure (CCSI and the second satellite in the ZiYuan3 series; it was launched successfully on 30 May 2016, aboard the CZ-4B rocket at the Taiyuan Satellite Launch Center (TSLC in China. Core payloads of ZY3-02 include a triple linear array camera (TLC and a multi-spectral camera, and this equipment will be used to acquire space geographic information with high-resolution and stereoscopic observations. Geometric quality is a key factor that affects the performance and potential of satellite imagery. For the purpose of evaluating comprehensively the geometric potential of ZY3-02, this paper introduces the method used for geometric calibration of the TLC onboard the satellite and a model for sensor corrected (SC products that serve as basic products delivered to users. Evaluation work was conducted by making a full assessment of the geometric performance. Furthermore, images of six regions and corresponding reference data were collected to implement the geometric calibration technique and evaluate the resulting geometric accuracy. Experimental results showed that the direct location performance and internal accuracy of SC products increased remarkably after calibration, and the planimetric and vertical accuracies with relatively few ground control points (GCPs were demonstrated to be better than 2.5 m and 2 m, respectively. Additionally, the derived digital surface model (DSM accuracy was better than 3 m (RMSE for flat terrain and 5 m (RMSE for mountainous terrain. However, given that several variations such as changes in the thermal environment can alter the camera’s installation angle, geometric performance will vary with the geographical location and imaging time changes. Generally, ZY3-02 can be used for 1:50,000 stereo mapping and can produce (and update larger-scale basic geographic information products.

  20. [The research on the edition of Daquanbencao (Complete Collection of Materia Medica)].

    Science.gov (United States)

    Li, Jian; Zhang, Wei; Zhang, Rui-xian

    2009-07-01

    Zhengleibencao (Classified Materia Medica) had been formed into several kinds of edition systems during its dissemination, among which there was the edition system of Daquanbencao (Complete Collection of Materia Medica). Daquanbencao was originally carved in the Jin dynasty, thereafter it was re-carved in the Yuan, Ming and Qing dynasties so as to form a series of editions such as the edition of Zhenyou in the second year of the Jin dynasty; the edition of the Zongwenshuyuan college in Dade renyan year of the Yuan dynasty; the WANG Qiu's carved edition of Shangyitang hall in the Ming dynasty; the carved edition of Jishanshuyuan, the Jishang mountain college in the Ming dynasty, the reprinted edition of PENG Duan-wu in the Ming dynasty, the supplementary edition of YANG Bi-da in the Qing dynasty;, and the carved edition of KE Feng-shi in the Qing dynasty. Among all the editions, Chongkanjingshizhengleidaquanbencao (Reprinted Classified Daquan Materia Medica from Historical Classics) was the representative one. As a representative of the above editions, the carved edition of WANG took the edition of the Zongwenshuyuan college of the Yuan dynasty as the original edition, but the images picture of materia medica adopted from the edition of Zhenghebencao (Materia Medica of the Zhenghe era).

  1. An Introduction to Human Resource Development in Taiwan, R.O.C. = Jong Hwa Min Gwo Ren Li Tz Yuan Fa Jaan Jyan Jieh.

    Science.gov (United States)

    Lee, Lung-Sheng; Chen, Ya-Yan

    In Taiwan, human resource development (HRD) is defined as the systematic education, training, and development employers provide for their employees as well as organizational development for corporations. A history of HRD development indicates that in the 1960s, the government began to implement planning measures for HRD in business and industry;…

  2. 專論/專利指標發展研究/阮明淑、梁峻齊(Ming-Shu Yuan, Chun-Chi Liang

    Directory of Open Access Journals (Sweden)

    阮明淑、梁峻齊 Ming-Shu Yuan, Chun-Chi Liang

    2009-10-01

    Full Text Available 有鑑於專利資訊在現今產業發展中扮演重要的角色,專利指標成為度量專利資訊的重要參考。本文整理專利指標的發展演進及其在臺灣地區的相關研究,歸納出專利指標的應用分類與意涵。目前在臺灣地區的專利指標相關應用研究中,可以將專利指標區分為專利一般特性指標、專利引用指標與專利技術指標等,分別描述專利的一般特徵、引用與被引用的情況,以及技術的表現。如此正好呈現專利資訊的本質,若再配合時間與專業領域的因素,並以數量、頻率或複合指標的形式呈現,即可對公司、產業與國家等不同的對象���供適切之參考依據。本研究說明目前專利指標研究的概況,可以作為未來相關專利指標研究發展的基礎,更希望可以提供相關政策制定和產業佈局上專利指標選用之參考。 Because nowadays the patent information plays the important role of the industrial development, the patent indexes become the important reference to evaluate the patent information. This article provides the development of the patent indexes and related researches in Taiwan, and generalizes the application of classification and implication of the patent indexes. Presently the related patent index researches in Taiwan could be distinguished the patent indexes into general characteristic, the quotation and the technology and so on. Such discrimination shows the essence of the patent information and if it can compare with the factors of time and professional fields and presents in the forms of the quantity, frequency or composite indexes, it can provide the appropriate information to the company, the industry or the country. This article not only offers the understanding of the present researches of the patent indexes, but also provides the reference of the policy formulation and the industrial layout. 頁次:88-106

  3. Ganja, závoje zbavená - klady a zápory možných terapeutik na bázi THC

    Czech Academy of Sciences Publication Activity Database

    Drašar, Pavel

    2001-01-01

    Roč. 95, č. 11 (2001), s. 736-737 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /36./. 19.11.2001-21.11.2001, Nymburk] Institutional research plan: CEZ:AV0Z4055905 Subject RIV: CE - Biochemistry

  4. ETO: hybridní polovodičová součástka na bázi vypínacího tyristoru GTO

    Czech Academy of Sciences Publication Activity Database

    Bartoš, Stanislav

    2006-01-01

    Roč. 16, č. 10 (2006), s. 4-6 ISSN 1210-0889 Institutional research plan: CEZ:AV0Z20570509 Keywords : ETO versus IGCT * hard- driven communication * benefits of ETO Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  5. Technology Education and Technology Teacher Education in Taiwan, R.O.C. = Zhong Hua Min Guo Ke Ji Jiao Yu Ji qi shi zi Jiao Yu.

    Science.gov (United States)

    Lee, Lung-Sheng Steven; Wang, Cheng-Pin Peter; Wang, Yen-chao; Shih, Neng-Mu; Yeh, Chung-ching

    Technology education in Taiwan begins with craft work at the elementary school level, and the most important point is the practical application. All junior high school students are required to take the Living Technology course. Content includes technology and life, information and communication, construction and manufacturing, and energy and…

  6. Studium interakcí hydroxylových radikálů a purinových bázi DNA

    Czech Academy of Sciences Publication Activity Database

    Fadrná, Renata

    2003-01-01

    Roč. 97, č. 9 (2003), s. 964-969 ISSN 0009-2770 Grant - others:GIT(AR) 101/02/U111/CZ Institutional research plan: CEZ:AV0Z4040901 Keywords : DNA * voltammetry * nucleids acids Subject RIV: CG - Electrochemistry Impact factor: 0.345, year: 2003

  7. Srovnání koroze historických a moderních materiálů na bázi železa

    Czech Academy of Sciences Publication Activity Database

    Majtás, Dušan; Pérez-Estébanez, Marta; Kreislová, K.; Mácová, Petra

    2016-01-01

    Roč. 2016, č. 1 (2016), s. 74-79. ISBN 978-80-87896-32-7. ISSN 1805-0050. [Konference konzervátorů-restaurátorů. Brno, 13.09.2016-15.09.2016] R&D Projects: GA MŠk(CZ) LO1219 Keywords : cultural heritage * metallic objects * corrosion Subject RIV: JK - Corrosion ; Surface Treatment of Materials

  8. 16 YAŞ GRUBU SPORCU GENÇ KIZLARDA MAX V02 VE BA ZI SOLUNUM PARAMETRELERİ ÜZERİNE BİR ARAŞTIRMA

    OpenAIRE

    MOĞULKOÇ, Rasim; BALTACI, A. Kasım; KELEŞTÎMUR, Haluk; KOÇ, Selahattin; ÖZMERDİVENLİ, Recep

    2018-01-01

    Atletizm ve basketbol sporunun 16 yaş grubu genç kızlarda bazı solunum parametreleri ile maksimal oksijen voliimii (MaxV02)'nü nasıl etkilediğinin ortaya konulabilmesi amacıyla planlanan çalışma, 12 kişilik kontrol ile 5 yıldır aktif spor yapan İS kişilik atletizm, 12 kişilik basketbolcu olmak üzere toplam 42 birey üzerinde gerçekleştirildi. Deneklerin MaxVOl'u indirekt metodla (Cooper Testi) ve solunum parametreleri spirometrede kuru sistemle tay...

  9. The relationship of family relations and interpersonal skills with communication technology [Więzi rodzinne i umiejętności interpersonalne a technologie komunikacyjne

    Directory of Open Access Journals (Sweden)

    Jolanta JAWORSKA

    2017-11-01

    Full Text Available The paper presents the role of proper relations within the family environment in a child’s social development and its influence on the quality of future relations with other people. Emphasis is put on the importance of a child’s first relations in its emotional development and the necessity to support a young person on their way to independence as a means of protection against loneliness and desperate attempts to seek social relations through communication technology. The function of affection is fundamental to a person’s development. The theory of affection explains the different forms of human emotional functioning. The author defines four patterns of affection: a trustful, an anxious and avoidant, an anxious and ambivalent, and a disorganised relation. Improper models cause developmental disorders. They influence a person’s entire life, their social skills and interpersonal relations. They result in problems with coming into one’s own, finding one’s identity, establishing proper relationships with one’s peers which constitute a great value for a young person. Improper attitudes of adults frequently block the development of autonomy and proper relationships of teenagers. The lack of relations with peers leads to anxiety and fear of loneliness, incapability of fulfilling the need to belong to a group initiates defensive mechanisms. For some they may lead to looking for contacts on the internet. The computer screen serves as a shield, it relieves one of the feeling of loneliness, leads to feeling of well-being. With its role as a substitute of peer relations in the real world, the internet may be a form of spending leisure time, a source of topics for discussion and games, a facilitator of identification with a peer group and its values, and even a plain for the development of individual identity. Media not only create social and educational chances, but they are also a source of dangers and addictions. The effects of internet addiction may take on various forms. The so-called paradox of the internet needs to be mentioned. Although the internet is used to communicate with others, its use leads to a weakening of the relations with one’s environment and increasing the feeling of loneliness. In order to support young people in establishing responsible and satisfying relations they should be provided with help in acquiring social skills which are the basic source of relations of affection and proper upbringing styles

  10. Příprava a charakterizace nanonosičů na bázi diamantu pro transfekci siRNA

    OpenAIRE

    Majer, Jan

    2016-01-01

    Although nanodiamonds were discovered and produced tens of years ago, they have been utilized in medical and biological fields just recently, particularly in drug and gene delivery into a cell and in bioimaging methods. Nanodiamonds can be modified with specific positively charged moieties for complexation with negatively charged nucleic acids. These complexes afterwards overcome extracellular and intracellular barriers and transport the nucleic acid either into cytosol or into the nucleus. O...

  11. Úzkopásmová PLC komunikace s vysokou datovou rychlostí na bázi OFDM techniky

    OpenAIRE

    Csiba, Patrik

    2015-01-01

    Tato bakalářská práce se zabývá úzkopásmovou PLC komunikací. V práci je popisována historie, princip úzkopásmové komunikace a popis čtyř dostupných úzkopásmových standardů (PRIME, G3-PLC, G.hnem, IEEE P1901.2) s jejich porovnáním. V další části jsou popisována experimentální měření, která jsou prováděna v domácím prostředí za použití dostupných modemů TMDSPLCKIT od firmy Texas Instruments, MT39-L1-ver.R modemů od firmy ModemTec a EVALKITST7580-1 od firmy STMicroelectronics. This bachelor p...

  12. Chemie iontů v plynné fázi a ve srážkách s povrchy

    Czech Academy of Sciences Publication Activity Database

    Herman, Zdeněk; Španěl, Patrik; Polášek, Martin; Roithová, Jana

    2005-01-01

    Roč. 55, č. 6 (2005), s. 591-596 ISSN 0009-0700 Institutional research plan: CEZ:AV0Z40400503 Keywords : chemical physics * SIFT mass spectrometry * SIMS Subject RIV: CF - Physical ; Theoretical Chemistry

  13. Jakostní požadavky na dříví smrku pro stavby na bázi dřeva

    OpenAIRE

    Nevřela, Josef

    2016-01-01

    The Bachelor thesis is focusing on issues of quality requirements of spruce-wood for wood-based buildings in Czech Republic. It contains detailed description of qualities which are valid for spruce-wood range of products in Czech Republic. The thesis also depicts the usage of spruce-wood range of products in wood-based buildings, furthermore comparison of qualities used by companies in terms of various markings. The thesis contains survey of companies from the field of wood-constructions show...

  14. Agrese a násilí vůči pedagogům pohledem pedagogů na gymnáziích

    OpenAIRE

    Franková, Monika

    2012-01-01

    The master thesis entitled Aggression and Violence towards Educators - from the Perspective of Secondary School Educators elaborates the problem of aggression and violence in school. The theoretical part contents a general description of the phenomena aggression and violence, further it focuses on school aggression, violence among pupils (bullying, cyber bullying) and other forms of school violence. The main research problems of the thesis are two forms of school violence: these are aggressio...

  15. Syntéza antimikrobiálních látek na bázi derivátů salicylové kyseliny

    OpenAIRE

    Tvrdý, Václav

    2016-01-01

    Schiff bases are widely used both in technical practice and in the field of medicine. For their antimicrobial activities are studied as potential antimacterial and abtifungal drugs. With increasing level of resistence to currently drugs is the development of new substances very intense. Salicylanilides are a group of substances with antimicrobial activity and are also intensively studied. Based on that we were synthesized novel Schiff bases resulting from salicylic acid, respectively salicyla...

  16. Kombinované sorbenty kovů na bázi nízkoenergetických uhlí a chitosanu

    Czech Academy of Sciences Publication Activity Database

    Mizera, Jiří; Havelcová, Martina; Machovič, Vladimír; Borecká, Lenka; Krausová, Ivana

    2009-01-01

    Roč. 5, č. 9 (2009), s. 213-214 ISSN 1336-7242. [Zjazd chemikov/61./. Tatranské Matliare, 07.09.2009-11.09.2009] R&D Projects: GA ČR GA106/09/0735 Institutional research plan: CEZ:AV0Z30460519; CEZ:AV0Z10480505 Keywords : chitosan * sorbent * oxihumolite Subject RIV: DD - Geochemistry

  17. Návrh materiálu na bázi dřeva s požární odolností

    OpenAIRE

    Jeřábková, Lucie

    2016-01-01

    Bachelor thesis compares the properties of composite materials with basalt fiber or with glass fiber. The main objective is comparison of the mechanical properties, which include fire resistance. Concretely, thesis will deal with bending properties of composite material with basalt fiber. These properties of composite material with basalt fiber will be compared with the bending properties of the composite material with glass fiber and plywood. The second part will deal with fire resistance of...

  18. History Writ Large: Big-character Posters, Red Logorrhoea and the Art of Words

    Directory of Open Access Journals (Sweden)

    Geremie R. Barmé

    2013-01-01

    Full Text Available The starting point of this paper is the 1986 artwork of the then Xiamen-based artist Wu Shanzhuan, called ‘Red Humor’, which reworked references to big-character posters (dazi bao 大字报 and other Mao-era forms of political discourse, recalling the Cultural Revolution. It explains how Wu’s installation offered a provocative microcosm of the overwhelming mood engendered by a logocentric movement to ‘paint the nation red’ with word-images during the years 1966-1967. This discussion of the hyper-real use of the dazi bao during China’s Cultural Revolution era (c.1964-1978 allows us to probe into ‘the legacies of the word made image’ in modern China. The paper argues that, since the 1980s, Wu Shanzhuan has had many emulators and ‘avant-garde successors’, since we have seen multiple examples of parodic deconstructions of the cultural authority of the Chinese character (zi in recent decades.

  19. 圖書館事業與交流/The Relationship of Leadership Development and Learning Organization Dimensions/Connie K. Haley, Yuhfen Diana Wu

    Directory of Open Access Journals (Sweden)

    Connie K. Haley, Yuhfen Diana Wu Connie K. Haley, Yuhfen Diana Wu

    2011-10-01

    Full Text Available This research examined the relationship among learning organization dimensions, leadership development, employee development, and their interactions with two demographic variables (gender and ethnicity in the context of libraries. The researchers conducted a multivariate analysis of the variance to assess the differences by leadership training groups (low training hours vs. high training hours, or by gender; and by workplace training groups (low vs. high, or by ethnicity (white vs. all others on a linear combination of the seven dimensions of the learning organization. A conclusive summary is provided along with contributive discussion. Implications and contributions to librarians are discussed in addition to future research recommendations. Also included are conclusive final thoughts accompanied by the limitations of this research. 本研究旨在探討美國圖書館界學習型組織,領導智能與員工發展之間的關系,以及它們與兩項人口變量(性別、種族)的相互作用。作者採用線性組合研究了學習型組織的七個範疇,並且使用多變量變異數分析方法來評估領導智能培訓組的差異(培訓時數多寡對比),在職培訓組的差異(培訓時數多寡對比),及種族的差異(白人或其他族裔對比)。除了討論未來研究方向的建議,作者並提供人力資源發展工作者和圖書館員一些啟示。研究最後提出作者的想法及本研究的侷限性。 頁次:146-165

  20. Impacts of land use change scenarios on hydrology and land use patterns in the Wu-Tu watershed in Northern Taiwan

    NARCIS (Netherlands)

    Lin Yu-Pin,; Hong Nien-Ming,; Wu Pei-Jung,; Wu Chen-Fa,; Verburg, P.H.

    2007-01-01

    Developing an approach for simulating and assessing land use changes and their effects on land use patterns and hydrological processes at the watershed level is essential in land use and water resource planning and management. This study provided a novel approach that combines a land use change

  1. The Review on Leveraging Success of Young Scholars in Business Discipline edited by Maciej Mitręga, CeDeWu, Warszawa 2014

    Directory of Open Access Journals (Sweden)

    Peter Kovacs

    2017-04-01

    Full Text Available The study aims to give a comprehensive review of young business scholars in the Visegrad countries (Poland, the Czech Republic, Slovakia and Hungary, describing their scientific performance, prospects and possibilities. The study provides a detailed analysis of the specific situation of the Visegrad countries through examining young scholars facing the challenge of 'publish or perish' in a changing academic world.(fragment of text

  2. 3.-6. II saab neljal järjestikusel õhtul kella 18-21 imetleda valguskuplit Tallinna vanalinna kohal

    Index Scriptorium Estoniae

    2005-01-01

    Valguskupli idee pärineb hollandi arhitektilt Winy Maasilt. Installatsioon on ZiZi & YoYo, MVRDV ja Arup grupi koostööprojekt. Kupli on teostanud ZiZi & YoYo koos Rogier van de Heide, Teemu Nurmelini jt. koostööpartneritega

  3. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

    Directory of Open Access Journals (Sweden)

    Hong X

    2013-09-01

    Full Text Available Xiaoyun Hong,1,2,* Liangming Wei,3,* Fei Wu,2,* Zaozhan Wu,2 Lizhu Chen,2 Zhenguo Liu,1 Weien Yuan2 1Department of Neurology, Xinhua Hospital, Shanghai, People's Republic of China; 2School of Pharmacy, Shanghai JiaoTong University, Shanghai, People's Republic of China; 3Research Institute of Micro/Nano Science and Technology, Shanghai JiaoTong University, Shanghai, People's Republic of China *These authors contributed equally to this work Abstract: Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation. Keywords: microneedle, dissolving, biodegradable, sustained release

  4. Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis

    Directory of Open Access Journals (Sweden)

    Yang HW

    2012-10-01

    Full Text Available Hung-Wei Yang,1,* Mu-Yi Hua,1,* Kun-Ju Lin,2,* Shiaw-Pyng Wey,3 Rung-Ywan Tsai,4 Siao-Yun Wu,5 Yi-Ching Lu,5 Hao-Li Liu,6 Tony Wu,7 Yunn-Hwa Ma5 1Chang Gung Molecular Medicine Research Center, Department of Chemical and Materials Engineering, 2Molecular Imaging Center, Department of Nuclear Medicine, Chang Gung Memorial Hospital, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China; 3Department of Medical Imaging and Radiological Sciences, 4Electronics and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsin-chu, Taiwan, Republic of China; 5Department of Physiology and Pharmacology and Healthy Aging Research Center, 6Department of Electrical Engineering, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, Republic of China; 7Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, Tao-Yuan, Taiwan, Republic of China*These authors contributed equally to this workAbstract: Low-toxicity magnetic nanocarriers (MNCs composed of a shell of poly [aniline-co-N-(1-one-butyric acid aniline] over a Fe3O4 magnetic nanoparticle core were developed to carry recombinant tissue plasminogen activator (rtPA in MNC-rtPA for targeted thrombolysis. With an average diameter of 14.8 nm, the MNCs exerted superparamagnetic properties. Up to 276 µg of active rtPA was immobilized per mg of MNCs, and the stability of the immobilized rtPA was greatly improved during storage at 4°C and 25°C. In vitro thrombolysis testing with a tubing system demonstrated that magnet-guided MNC-rtPA showed significantly improved thrombolysis compared with free rtPA and reduced the clot lysis time from 39.2 ± 3.2 minutes to 10.8 ± 4.2 minutes. In addition, magnet-guided MNC-rtPA at 20% of the regular rtPA dose restored blood flow within 15–25 minutes of treatment in a rat embolism model without triggering hematological toxicity. In conclusion, this improved system is based on magnetic targeting accelerated thrombolysis and is

  5. Framework of Jitter Detection and Compensation for High Resolution Satellites

    Directory of Open Access Journals (Sweden)

    Xiaohua Tong

    2014-05-01

    Full Text Available Attitude jitter is a common phenomenon in the application of high resolution satellites, which may result in large errors of geo-positioning and mapping accuracy. Therefore, it is critical to detect and compensate attitude jitter to explore the full geometric potential of high resolution satellites. In this paper, a framework of jitter detection and compensation for high resolution satellites is proposed and some preliminary investigation is performed. Three methods for jitter detection are presented as follows. (1 The first one is based on multispectral images using parallax between two different bands in the image; (2 The second is based on stereo images using rational polynomial coefficients (RPCs; (3 The third is based on panchromatic images employing orthorectification processing. Based on the calculated parallax maps, the frequency and amplitude of the detected jitter are obtained. Subsequently, two approaches for jitter compensation are conducted. (1 The first one is to conduct the compensation on image, which uses the derived parallax observations for resampling; (2 The second is to conduct the compensation on attitude data, which treats the influence of jitter on attitude as correction of charge-coupled device (CCD viewing angles. Experiments with images from several satellites, such as ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiaometer, LRO (Lunar Reconnaissance Orbiter and ZY-3 (ZiYuan-3 demonstrate the promising performance and feasibility of the proposed framework.

  6. Main Road Extraction from ZY-3 Grayscale Imagery Based on Directional Mathematical Morphology and VGI Prior Knowledge in Urban Areas

    Science.gov (United States)

    Liu, Bo; Wu, Huayi; Wang, Yandong; Liu, Wenming

    2015-01-01

    Main road features extracted from remotely sensed imagery play an important role in many civilian and military applications, such as updating Geographic Information System (GIS) databases, urban structure analysis, spatial data matching and road navigation. Current methods for road feature extraction from high-resolution imagery are typically based on threshold value segmentation. It is difficult however, to completely separate road features from the background. We present a new method for extracting main roads from high-resolution grayscale imagery based on directional mathematical morphology and prior knowledge obtained from the Volunteered Geographic Information found in the OpenStreetMap. The two salient steps in this strategy are: (1) using directional mathematical morphology to enhance the contrast between roads and non-roads; (2) using OpenStreetMap roads as prior knowledge to segment the remotely sensed imagery. Experiments were conducted on two ZiYuan-3 images and one QuickBird high-resolution grayscale image to compare our proposed method to other commonly used techniques for road feature extraction. The results demonstrated the validity and better performance of the proposed method for urban main road feature extraction. PMID:26397832

  7. Rigorous Line-Based Transformation Model Using the Generalized Point Strategy for the Rectification of High Resolution Satellite Imagery

    Directory of Open Access Journals (Sweden)

    Kun Hu

    2016-09-01

    Full Text Available High precision geometric rectification of High Resolution Satellite Imagery (HRSI is the basis of digital mapping and Three-Dimensional (3D modeling. Taking advantage of line features as basic geometric control conditions instead of control points, the Line-Based Transformation Model (LBTM provides a practical and efficient way of image rectification. It is competent to build the mathematical relationship between image space and the corresponding object space accurately, while it reduces the workloads of ground control and feature recognition dramatically. Based on generalization and the analysis of existing LBTMs, a novel rigorous LBTM is proposed in this paper, which can further eliminate the geometric deformation caused by sensor inclination and terrain variation. This improved nonlinear LBTM is constructed based on a generalized point strategy and resolved by least squares overall adjustment. Geo-positioning accuracy experiments with IKONOS, GeoEye-1 and ZiYuan-3 satellite imagery are performed to compare rigorous LBTM with other relevant line-based and point-based transformation models. Both theoretic analysis and experimental results demonstrate that the rigorous LBTM is more accurate and reliable without adding extra ground control. The geo-positioning accuracy of satellite imagery rectified by rigorous LBTM can reach about one pixel with eight control lines and can be further improved by optimizing the horizontal and vertical distribution of control lines.

  8. Main Road Extraction from ZY-3 Grayscale Imagery Based on Directional Mathematical Morphology and VGI Prior Knowledge in Urban Areas.

    Science.gov (United States)

    Liu, Bo; Wu, Huayi; Wang, Yandong; Liu, Wenming

    2015-01-01

    Main road features extracted from remotely sensed imagery play an important role in many civilian and military applications, such as updating Geographic Information System (GIS) databases, urban structure analysis, spatial data matching and road navigation. Current methods for road feature extraction from high-resolution imagery are typically based on threshold value segmentation. It is difficult however, to completely separate road features from the background. We present a new method for extracting main roads from high-resolution grayscale imagery based on directional mathematical morphology and prior knowledge obtained from the Volunteered Geographic Information found in the OpenStreetMap. The two salient steps in this strategy are: (1) using directional mathematical morphology to enhance the contrast between roads and non-roads; (2) using OpenStreetMap roads as prior knowledge to segment the remotely sensed imagery. Experiments were conducted on two ZiYuan-3 images and one QuickBird high-resolution grayscale image to compare our proposed method to other commonly used techniques for road feature extraction. The results demonstrated the validity and better performance of the proposed method for urban main road feature extraction.

  9. Main Road Extraction from ZY-3 Grayscale Imagery Based on Directional Mathematical Morphology and VGI Prior Knowledge in Urban Areas.

    Directory of Open Access Journals (Sweden)

    Bo Liu

    Full Text Available Main road features extracted from remotely sensed imagery play an important role in many civilian and military applications, such as updating Geographic Information System (GIS databases, urban structure analysis, spatial data matching and road navigation. Current methods for road feature extraction from high-resolution imagery are typically based on threshold value segmentation. It is difficult however, to completely separate road features from the background. We present a new method for extracting main roads from high-resolution grayscale imagery based on directional mathematical morphology and prior knowledge obtained from the Volunteered Geographic Information found in the OpenStreetMap. The two salient steps in this strategy are: (1 using directional mathematical morphology to enhance the contrast between roads and non-roads; (2 using OpenStreetMap roads as prior knowledge to segment the remotely sensed imagery. Experiments were conducted on two ZiYuan-3 images and one QuickBird high-resolution grayscale image to compare our proposed method to other commonly used techniques for road feature extraction. The results demonstrated the validity and better performance of the proposed method for urban main road feature extraction.

  10. An Uneven Illumination Correction Algorithm for Optical Remote Sensing Images Covered with Thin Clouds

    Directory of Open Access Journals (Sweden)

    Xiaole Shen

    2015-09-01

    Full Text Available The uneven illumination phenomenon caused by thin clouds will reduce the quality of remote sensing images, and bring adverse effects to the image interpretation. To remove the effect of thin clouds on images, an uneven illumination correction can be applied. In this paper, an effective uneven illumination correction algorithm is proposed to remove the effect of thin clouds and to restore the ground information of the optical remote sensing image. The imaging model of remote sensing images covered by thin clouds is analyzed. Due to the transmission attenuation, reflection, and scattering, the thin cloud cover usually increases region brightness and reduces saturation and contrast of the image. As a result, a wavelet domain enhancement is performed for the image in Hue-Saturation-Value (HSV color space. We use images with thin clouds in Wuhan area captured by QuickBird and ZiYuan-3 (ZY-3 satellites for experiments. Three traditional uneven illumination correction algorithms, i.e., multi-scale Retinex (MSR algorithm, homomorphic filtering (HF-based algorithm, and wavelet transform-based MASK (WT-MASK algorithm are performed for comparison. Five indicators, i.e., mean value, standard deviation, information entropy, average gradient, and hue deviation index (HDI are used to analyze the effect of the algorithms. The experimental results show that the proposed algorithm can effectively eliminate the influences of thin clouds and restore the real color of ground objects under thin clouds.

  11. Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells

    Directory of Open Access Journals (Sweden)

    Wang Y

    2012-05-01

    Full Text Available Ye Wang,1,2,* Xiao-Yuan Zi,1,* Juan Su,1 Hong-Xia Zhang,1 Xin-Rong Zhang,3 Hai-Ying Zhu,1 Jian-Xiu Li,1 Meng Yin,3 Feng Yang,3 Yi-Ping Hu,11Department of Cell Biology, 2School of Clinical Medicine, 3Department of Pharmaceuticals, Second Military Medical University, Shanghai, People's Republic of China*Authors contributed equally.Abstract: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.Keywords: nanomedicine, selective cytotoxicity, apoptosis, cell cycle arrest, mitochondrion-targeted nanomaterials

  12. 从《开元占经》看《三国演义》的星相占验%Understanding Astrology in the Romance of the Three Kingdoms with Theories from Kai Yuan Zhan Jing

    Institute of Scientific and Technical Information of China (English)

    张涛

    2015-01-01

    成书于公元8世纪左右的《开元占经》集天文学与占星术于一体,将“究天人之际,通古今之变”的三材之道与占卜结合起来,可谓是最具东方特色的古代天文学专著.以《开元占经》作为《三国演义》中有关观天预卜、禳星求福、星象变异、九州分野、灾异福瑞等现象的解读根据,分析其中星宿变化所对应的朝代更替、将相生死、人事变迁、行军布阵,可以帮助现代读者站在古代天文星象学角度更为全面地了解这部内蕴深厚、思想宏博的文学巨著.

  13. 圖書館事業與交流/Strategies for Developing an Institutional Repository: A Case Study of ScholarWorks@ UMass Amherst/Yuan Li, Marilyn Billings

    Directory of Open Access Journals (Sweden)

    Yuan Li Yuan Li

    2011-04-01

    Full Text Available ScholarWorks@UMass Amherst is an institutional repository that collects, manages, and disseminates intellectual output of UMass Amherst faculty, researchers, and students. In less than five years, it has become one of the top five Digital Commons repositories with more than 23,000 items and over half-a-million full-text downloads. ScholarWorks content recruitment strategies are examined as a case study for the development of an institutional repository. The authors aim to provide best practices for developing a digital repository in academic settings and inspire colleagues to explore and adapt new strategies. ScholarWorks@UMass Amherst 是麻省大學安城校區的機構典藏,主要用於收集、管理和發布本校教師、研究人員和學生的學術成果。自建立至今不到五年的時間,以23,000 件的學術成果收藏量和超過五十萬份的文件下載數,躋身為Digital Commons 排名前五的機構典藏。本文以ScholarWorks 的發展策略為實例來探究機構典藏的發展,旨在提供一實施範例作為同行參考,並期望能以此啟發業內同行開發與新策略採用。 頁次:81-98

  14. 專論/大學社群之共同故事萃取研究/阮明淑 | The Study on Extraction of Common Organizational Story within University Community / Ming-Shu Yuan

    Directory of Open Access Journals (Sweden)

    阮明淑 Ming-Shu Yuan

    2007-10-01

    Full Text Available

    說故事(storytelling為人類傳承文化及智慧的一種方式。在組織中,透過說故事能有效的轉移內隱知識,促進組織內外的溝通及學習,並有 助於組織價值的建立。大學是創新知識的重要來源之一,在知識經濟時代中佔有重要地位,若能善加利用說故事之方式,必能更有效傳播大學之理念、精神與文化。 因此本研究以世新大學為個案研究,使用深度訪談法萃取大學社群之組織共同故事,及共同故事對社群成員的意義與價值。研究結果歸納出六類世新大學之組織共同 故事,而其中,創辦人對於世新大學組織中之資深教職員影響深遠。

    Storytelling is a way of passing on wisdom and culture. In an organization, storytelling can transfer tacit knowledge effectively, improve communication and learning among members, and create organization value. Universities are important resources of innovative knowledge in the age of knowledge-based economy. The idea, spirit, and culture of universities can be conveyed effectively by storytelling. Based on the in-depth interviews, this study extracts common stories within university community and the meaning and value of those stories. Shih Hsin university is the survey object in this study. The result indicates that there are 6 types of common story in Shih Hsin University. furthermore, the common story about the founder of the institute has the greatest influence in the organization.

    頁次:64-80

  15. 狮子林:元江南临济山林禅的孑遗%The Lion Forest Garden: The Only Yuan Dynasty Garden of Rinzai Zen in Regions South of the Yangtze River

    Institute of Scientific and Technical Information of China (English)

    张婕

    2016-01-01

    世界遗产、苏州名园狮子林始建于元代,创立者天如惟则禅师是江南临济宗传人.历经600余年风雨变迁,狮子林亦寺亦园,屡易其主,现虽已改变了初建时的风貌,但大型拟态湖石假山群及多处禅意景点皆渗透禅理,营造出浓厚的佛教幻想意境,保留了山林禅的气息,成为元代江南园林临济宗孑遗,在中国寺庙园林史上硕果仅存,成为狮子林最令人瞩目的文化价值.

  16. Projects of Earth Sciences Supported by National Natural Science Foundation of China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    -shou 40001019\tGenetic Algorithm Approach to Automation and Intelligence of Map Name Placement\tFAN Hong 40001020\tEnvironmental Magnetic Study of Sedimentary Iron Cycling during Early Diagnoses\tZHANG Wei-guo 40001021\tModeling of Nitrogen and Water Input-yield-leaching Loss Response and the Nitrogen Transformation and Transportation\tZHANG Guo-liang 40001022\tThe Study on the Regional Differentiation of Lake Environment Response to Southwest Monsoon Climate\tPENG Jin-lan 40001023\tCritical Loads of Acid Deposition for Ecosystems and Their Exceedance in Regions Suffered from Acid Deposition in China\tTAO Fu-lu 40031010\tRegional Environmental Processes of Typical Trace Organic Pollutants\tTAO Shu 40061001\tAnalysis on the Structure of Karst Watershed and the Characteristics of Low Flow\tLIANG Hong 40061002\tThe Development Feature, Dynamic Mechanism and Coordination Research of Urban Concentric Region in West of Yunnan Province and Its Demonstration to Undeveloped, Minority Concentric Region of China\tWU Qi-yan 40061003\tThe REE Background Value and Its Influence on Soil Fertility in Laterite in the Hainan Island\tBI Hua 40061004\tStudies on the Mechanism of Soil Fertility Degradation and Techniques of Fertilization Under Arable Soils Condition in the "One-Jiang River and Two-He River" Region in Tibet\tCAI Xiao-bu 40061005\tA Study on Major Factors, Countermeasures and Mechanism of Bahia Grass Later-stage Degeneration at Rare-earth Tailings\tDONG Wen-da 40061006\tStudy on Soil Erosion and Land Use Security Pattern in Jinsha River Basin of Yunnan\tYANG Zi-sheng 40061007\tA Study on Environment Dynamic Chart of Southern Mountain Area of Ningxia under Eco-Restoration and Wide Development in West China\tSUI Yu-zhu 40061008\tThe Site Study of Environment Carrying Capacity for Tourism in Bita Reserve, Northwestern Yunnan\tYANG Gui-hua 40071001\tResearch on Sedimentary Processes and Varve Records of Lake Environment for Meromictic Lake on the Qinghai-Xizang (Tibet) Plateau\tLI Shi

  17. Využití hydrofóbních materiálů na bázi oxidu zirkoničitého pro úpravu vzorku

    OpenAIRE

    Nezvedová, Markéta

    2015-01-01

    - 1 - Abstract Application of hydrophobic materials based on zirconium dioxide for sample pre-treatment Rigorous thesis Mgr. Markéta Nezvedová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis Heyrovského 1203, Hradec Králové. In case of an analysis of a biological sample it is necessary to pre-treat the sample before the HPLC (High Performance Liquid Chromatography) analysis. The aim is to remove ballast components, ...

  18. Reactive Attachment Disorder (RAD in children living in a special childcare centres [Reaktywne zaburzenia więzi (RAD u dzieci przebywających w placówkach opiekuńczo-wychowawczych

    Directory of Open Access Journals (Sweden)

    Liliana KOŁODZIEJCZAK

    2017-11-01

    Full Text Available The role of parents in the upbringing of the child is especially important for a normal socialization and the successful development of the individual. But what happens when the child instead of receiving from their parents the a sense of security, respect and love, suffers extreme neglect or even abuse? And furthermore, how may the child feel that, despite numerous sufferings, is in the end is rejected by their loved-torturers and goes to the special education centre? As a result of adverse experiences such an entity may be accompanied by Reactive Attachment Disorder. RAD is a disorder of human relationships, which prevents initiating and maintaining relationships – especially those with loved ones. RAD makes it difficult, not only for the child, but also to those seeking to establish a deep, emotional contact with the child. Employees of childcare centres trying to break the barrier put up by the child who displays increasing resistance, undisguised reluctance, and sometimes aggression. Also an adoptive family faces the problem. Fresh parents see the fault in themselves, because when faced with such complex disorders of their child they do not have the knowledge of what to do to help the child feel at ease in their company. The article will widely discuss Reactive Disorders ties with pupils care and educational institution, their causes, diagnostic criteria and symptoms.

  19. Transformations of the family – social bond in the 21st century family [Przeobrażenia więzi rodzinno-społecznych w rodzinie XXI wieku

    Directory of Open Access Journals (Sweden)

    Urszula GAŁĘSKA

    2017-11-01

    Full Text Available The concept of the family (social bond has not been explained and precisely defined so far. The most common definition is known as a dual character of human relationships. Cultural, economic, legal, religious and social factors in which a family lives, influence considerably the typical family bonds. Transformations of the bond in the 21st century family are caused by changes which have occurred and continuue to occur in the structure, functions and organization of the family live. A system of mutually connected elements of the upbringing process in the family, between which all kinds of dynamic associations and interactions are clearly visible. So we should pay our attention to transformations of the family bond in incessantly changing conditions. It is necessary especially in social, economic and cultural areas, where the role of the traditional family is becoming less important.

  20. Vliv stupně sulfonace na mechanické a transportní vlastnosti membrán na bázi poly(2,6-dimethyl-1,4-fenylenoxidu)

    Czech Academy of Sciences Publication Activity Database

    Bouzek, K.; Podubecká, P.; Moravcová, S.; Schauer, Jan

    2004-01-01

    Roč. 95, č. 8 (2004), s. 541 ISSN 0009-2770. [Sjezd chemických společností /56./. 06.09.2004-09.09.2004, Ostrava] R&D Projects: GA AV ČR KSK4050111 Keywords : poly (phenylene oxide) * PEM fuel cell Subject RIV: CD - Macromolecular Chemistry

  1. Evaluación de los beneficios del Método Mézières incluido al programa de fisioterapia respiratoria de los pacientes con enfermedad pulmonar obstructiva crónica

    OpenAIRE

    Massoni, Anne-Charlotte

    2016-01-01

    La Enfermedad Pulmonar Obstructiva Crónica (EPOC), es un trastorno respiratorio causado mayoritariamente por el tabaquismo y caracterizado por una obstrucción progresiva y parcialmente reversible de las vías respiratorias, hiperinflación pulmonaria, manifestaciones sistémicas, expectoración anormal. Es la tercera causa de mortalidad en el mundo y se clasifica en 2: el enfisema y la bronquitis crónica. Nos centraremos en el aumento de deformaciones posturales, de la ansiedad y del dolor, la di...

  2. Jsou děti z víceletých gymnázií normální puberťáci? První výsledky z focus group

    Czech Academy of Sciences Publication Activity Database

    Vojtíšková, Kateřina

    2007-01-01

    Roč. 5, č. 9 (2007), s. 3-5 ISSN 1214-1720 R&D Projects: GA MŠk 2D06014 Institutional research plan: CEZ:AV0Z70280505 Keywords : leisure activities * focus group * family Subject RIV: AO - Sociology, Demography www.socioweb.cz

  3. Amabimus nos! Láska, žárlivost a nenávist na jevištích jezuitských gymnázií

    Czech Academy of Sciences Publication Activity Database

    Jacková, Magdaléna

    2014-01-01

    Roč. 4, č. 1 (2014), s. 21-30 ISSN 1804-6983 R&D Projects: GA ČR GPP406/12/P823 Institutional support: RVO:68378068 Keywords : Jesuit theatre * baroque drama * emotions Subject RIV: AJ - Letters, Mass-media, Audiovision

  4. Pokroky v syntéze molekulárních vodičů na bázi helicenových konjugátů

    Czech Academy of Sciences Publication Activity Database

    Rybáček, Jiří; Stará, Irena G.; Starý, Ivo

    2007-01-01

    Roč. 101, č. 11 (2007), s. 969 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /42./. 16.11.2007-18.11.2007, Liblice] R&D Projects: GA MŠk LC512; GA ČR GA203/06/1792 Institutional research plan: CEZ:AV0Z40550506 Keywords : helicenes * cyclotrimerisation * alkynes * Sonogashira reaction * molecular wires Subject RIV: CC - Organic Chemistry

  5. Christoph Landerer, Výuka logiky a psychologie na rakouských gymnáziích: Zimmermann, Lindner a jejich následný vliv - překlad

    Czech Academy of Sciences Publication Activity Database

    Bakešová, Alena

    2009-01-01

    Roč. 57, č. 4 (2009), s. 555-575 ISSN 0015-1831 Institutional research plan: CEZ:AV0Z90090514 Keywords : philosophical propaedeutics * Austrian schooling system * Herbartianism * "crisis of the self" Subject RIV: AA - Philosophy ; Religion

  6. Vývoj bioreaktorů na bázi imobilizovaných kultur ligninolytických hub pro biodegradaci průmyslových organických barviv

    Czech Academy of Sciences Publication Activity Database

    Novotný, Čeněk; Pavko, A.

    -, č. 1 (2010), s. 5-5 ISSN 1210-4612 R&D Projects: GA AV ČR IAA6020411; GA AV ČR IAAX00200901; GA MŠk MEB090629 Institutional research plan: CEZ:AV0Z50200510 Keywords : Irpex lacteus Subject RIV: EE - Microbiology, Virology

  7. K železářské výrobě kolem přelomu 12. a 13. století v Knovízi, okr. Kladno

    Czech Academy of Sciences Publication Activity Database

    Ježek, Martin; Řídký, Jaroslav; Varadzin, Ladislav; Zavřel, J.

    2011-01-01

    Roč. 63, č. 2 (2011), s. 331-339 ISSN 0323-1267 Institutional research plan: CEZ:AV0Z80020508 Keywords : Middle Ages * Central Bohemia * countryside * ironworks * metallurgy * raw mining Subject RIV: AC - Archeology, Anthropology, Ethnology

  8. Is Mo Zi Utilitarian: Contemporary Significance of Moist Ethics%墨子是功利主义者吗?--论墨家伦理思想的现代意义

    Institute of Scientific and Technical Information of China (English)

    郝长墀

    2005-01-01

    本文通过把墨子的兼爱思想与功利主义的功利原则、儒家的仁爱核心、莱维纳斯的我与他人的不对称关系相比较,得出了墨子思想可以是任何学派但绝对不是功利主义的结论.论证主要是围绕着"我"、"我们"、"他人"三个概念的关系展开的.墨子思想的现代性主要表现在它与当代西方伦理思想家莱维纳斯有着惊人的相似性.

  9. Casanovas are liars: behavioral syndromes, sperm competition risk, and the evolution of deceptive male mating behavior in live-bearing fishes [v3; ref status: indexed, http://f1000r.es/1zi

    Directory of Open Access Journals (Sweden)

    David Bierbach

    2013-10-01

    Full Text Available Male reproductive biology can by characterized through competition over mates as well as mate choice. Multiple mating and male mate choice copying, especially in internally fertilizing species, set the stage for increased sperm competition, i.e., sperm of two or more males can compete for fertilization of the female’s ova. In the internally fertilizing fish Poecilia mexicana, males respond to the presence of rivals with reduced expression of mating preferences (audience effect, thereby lowering the risk of by-standing rivals copying their mate choice. Also, males interact initially more with a non-preferred female when observed by a rival, which has been interpreted in previous studies as a strategy to mislead rivals, again reducing sperm competition risk (SCR. Nevertheless, species might differ consistently in their expression of aggressive and reproductive behaviors, possibly due to varying levels of SCR. In the current study, we present a unique data set comprising ten poeciliid species (in two cases including multiple populations and ask whether species can be characterized through consistent differences in the expression of aggression, sexual activity and changes in mate choice under increased SCR. We found consistent species-specific differences in aggressive behavior, sexual activity as well as in the level of misleading behavior, while decreased preference expression under increased SCR was a general feature of all but one species examined. Furthermore, mean sexual activity correlated positively with the occurrence of potentially misleading behavior. An alternative explanation for audience effects would be that males attempt to avoid aggressive encounters, which would predict stronger audience effects in more aggressive species. We demonstrate a positive correlation between mean aggressiveness and sexual activity (suggesting a hormonal link as a mechanistic explanation, but did not detect a correlation between aggressiveness and audience effects. Suites of correlated behavioral tendencies are termed behavioral syndromes, and our present study provides correlational evidence for the evolutionary significance of SCR in shaping a behavioral syndrome at the species level across poeciliid taxa.

  10. Přidaná hodnota studia na víceletých gymnáziích ve světle dostupných datových zdrojů

    Czech Academy of Sciences Publication Activity Database

    Straková, Jana

    2010-01-01

    Roč. 46, č. 2 (2010), s. 187-210 ISSN 0038-0288 R&D Projects: GA ČR GA403/08/0109 Institutional research plan: CEZ:AV0Z70280505 Keywords : student achievement * socioeconomic status * tracking Subject RIV: AO - Sociology, Demography Impact factor: 0.389, year: 2010 http://sreview.soc.cas.cz

  11. Raamat sõja seadustest / Linnart Mäll

    Index Scriptorium Estoniae

    Mäll, Linnart

    2001-01-01

    Vana-Hiina sõjateoreetikute Sun Zi ja Sun Bini raamatust: Sun, Zi ; Sun, Bin. Sõja seadused / klassikalisest hiina keelest tõlkinud ja kommenteerinud Märt Läänemets. Tln. : Eesti Keele Sihtasutus, 2001. (Sõjandusvaramu. Klassika)

  12. AFOSR (Air Force Office of Scientific Research) Technical Report Summaries, October-December 1986

    Science.gov (United States)

    1986-12-01

    Li LC~~~ C’:i OLL-r C, t’---~~ 7L L >, C~’-C (A f6 -c a. - Lr z - j- > L < C.L C, --- -- Cil m- i Ci c C cc <~ C2- C: CfL’Clf S CLUL 0-’C L al~ C0...n 3C LC - - U -L Cl - rn. xLI -0 - i a CCU W > U .0 -Mu V) C~ c v.(D 0) L) U L m cl c c c > 0 m,) MC0) z JLN < 0 rn C) aCCa - zi C-- -( ECIC , :zz...8217)O Ln .1. tE C- L C, 0 - m m7 r, 7C D 01 n L )cC t- 62 0) L) L L it L)C L C L.-) a)mC - r e 7C -. f6 L- a, -2 Ci -CI D- > w Ul WU mit C > Cin - .~ 0

  13. Modification to Math Model for Small Independent Action Forces (SIAF)

    Science.gov (United States)

    1973-12-15

    counterdetection situations. 1 6905-6008-RO-00 Page 2-44 WOcc = &&ls-.4 ZI- Lw _ _ _c__ _ _ _c z I.- 1 0 & a dC n u4.3C w 4.3 4n4 WLU cs td .~ 1--AiI I.- .C uj w...i et. - - S - U , )UU U aIA ~ U tiu W WQ wi W W U w td - l l -i M iA .j CA -o *m *o mc mc fP6-133 󈨁 a~ Ac a S o- I N S ag I 9E 30. Q CY " a𔃻 aac...I- 4f ow060 0 OLCO0 wuCo; O ~"-j~ I UzAc 30 1bd 4 OW b D- 6- 4bd d fo 6 udOw od Ś.464 .4 d Ot 6- 64W 6 b*64t PaI 7-55 NiI II a j l! I 1/. a

  14. Dollar Summary of Federal Supply Classification and Service Category by Company. Part 2 (B502-J066)

    Science.gov (United States)

    1990-01-01

    U 0 V ) V ( w~~~~ ae a11 - 4 W 4 0~~~~ a a4 " A 0 1> z~~~~ a. a0 4 0 4 1 4 ,0 4 - 4a%- %. 0 4a4 t4 i acca Lu awHIu 0a 0 0 0 Iw awa In InI I IK t0 n 4...6. 1 4. P7 4 % -. I-J x >- .4.-H %- t- 10 *- C 4 c 6. 01 C 4 .4 &i >, L. *.4 9U 10 0. l4. .- H C 0 3’ 0 c .4 X -4.4 ); Al 31 1. 0. 40V-4 3. Il- I... acca o - z ow zi1- crw z aa 0 0 w w-U 1-00 0 .Z 0 0 <~ ~0 0 : ac 0 ow 0w xD 0 0 1-w 0. < z :I- 0~ OcOZ0 0- H z< U n Z>- ao1 w 0 WI H Z 0 0 0 00-0 al

  15. Parental Choice of School, Class Strategies, and Educational Inequality: An Essay Review of "School Choice in China--A Different Tale?" (X. Wu, New York, NY: Routledge, 2014, 168 pp. ISBN 978-0-415-81769-1)

    Science.gov (United States)

    Liu, Shuning; Apple, Michael W.

    2016-01-01

    Given the increasingly global nature of marketized school choice policies, this makes it even more crucial to investigate how the multiple scales, forms, and emphases of school choice in different countries are influenced by particular political, economic, and cultural conditions. While much of the critical research on school choice policies has…

  16. 石头的记忆--吴少雄《惠安女人》舞剧音乐印象%Memory of Stones:Impressions of the Music of Wu Shaoxiong's Dance Drama Women of Huian

    Institute of Scientific and Technical Information of China (English)

    宋瑾

    2004-01-01

    @@ 2003年12月,由文化部主办的第三届全国舞剧观摩演出(比赛)在福州举行.由吴少雄作曲的荣获最佳作曲奖.这是作曲家继1992年(沈阳)第一届全国舞剧观摩演出(比赛)其作品(合作)获得作曲第一名之后,时隔11年再度捧冠.

  17. Russian olive - a suitable target for classical biological control in North America? In: Wu, Yun; Johnson, Tracy; Sing, Sharlene; Raghu, S.; Wheeler, Greg; Pratt, Paul; Warner, Keith; Center, Ted; Goolsby, John; Reardon, Richard, eds

    Science.gov (United States)

    K. Delaney; E. Espeland; A. Norton; S. Sing; K. Keever; J. L. Baker; M. Cristofaro; R. Jashenko; J. Gaskin; U. Schaffner

    2013-01-01

    Projects to develop biological control solutions against invasive plants are midto long-term endeavors that require considerable financial support over several years. Discussions of concerns and potential conflicts of interests often occur when biological control agents are first being proposed for release into the environment. Such late discussion, which in some cases...

  18. Correction: Wentao Wu, et al. Evolution Analysis of the Aux/IAA Gene Family in Plants Shows Dual Origins and Variable Nuclear Localization Signals. Int. J. Mol. Sci. 2017, 18, 2107

    Directory of Open Access Journals (Sweden)

    Wentao Wu

    2018-01-01

    Full Text Available The authors would like to insert some websites and citations in the following sentence, “First, the complete proteomes of these species were downloaded from the Phytozome website (Version 11; Available online: www.phytozome.org” in the “Materials and Methods” section on page 13, paragraph 3.1 of their paper published in the International Journal of Molecular Sciences [1].[...

  19. Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis

    Directory of Open Access Journals (Sweden)

    Ookawara Shigeo

    2008-04-01

    Full Text Available Abstract Background The zitter (zi/zi rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn, exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS in the brain. To date, the mechanisms underlying these phenotypes have remained unclear. Results Here, we show differentiation defects in zi/zi oligodendrocytes, accompanied by aberrant extension of cell-processes and hypomyelination. Axonal bundles were relatively preserved during postnatal development. With increasing in age, the injured oligodendrocytes in zi/zi rats become pathological, as evidenced by the accumulation of iron in their cell bodies. Immunohistochemical analysis revealed that atrn expression was absent from an oligodendrocyte lineage, including A2B5-positive progenitors and CNPase-positive differentiated cells. The number and distribution of Olig2-positive oligodendrocyte progenitors was unchanged in the zi/zi brain. Furthermore, an in vitro differentiation assay of cultured oligodendrocyte progenitors prepared from zi/zi brains revealed their normal competence for proliferation and differentiation into mature oligodendrocytes. Interestingly, we demonstrated the accelerated recruitment of ED1-positive macrophages/microglia to the developing zi/zi brain parenchyma prior to the onset of hypomyelination. Semiquantitative RT-PCR analysis revealed a significant up-regulation of CD26 and IL1-β in the zi/zi brain during this early postnatal stage. Conclusion We demonstrated that the onset of the impairment of oligodendrocyte differentiation occurs in a non-cell autonomous manner in zi/zi rats. Hypomyelination of oligodendrocytes was not due to a failure of the intrinsic program of oligodendrocytes, but rather, was caused by extrinsic factors that interrupt oligodendrocyte development. It is likely that macrophage/microglial activation in the zi/zi CNS leads to disturbances in

  20. Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis

    Directory of Open Access Journals (Sweden)

    Xu HX

    2016-01-01

    Full Text Available Hanxiao Xu,1 Yijun Tian,1 Xun Yuan,1 Yu Liu,2 Hua Wu,1 Qian Liu,1 Gen Sheng Wu,3,4 Kongming Wu1 1Department of Oncology, 2Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Oncology, 4Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA Abstract: Cluster of differentiation 44 (CD44 is a transmembrane glycoprotein that serves as the receptor for the extracellular matrix component hyaluronic acid. CD44 has been reported to play key roles in cell proliferation, motility, and survival, but its role in breast cancer remains controversial. In this study, we conducted a meta-analysis. A total of 23 published Gene Expression Omnibus databases were included to evaluate the association between CD44 mRNA expression and clinicopathological characteristics or prognosis of the patients with breast cancer. Our analysis revealed that CD44 expression was associated with clinicopathological features, including the histological grade, estrogen receptor status, progesterone receptor status, and human epidermal growth factor receptor-2 status. Higher levels of CD44 expression were observed in the basal subtype of breast cancer both at the mRNA and protein levels (odds ratio [OR] =2.08, 95% confidence interval [CI]: 1.72–2.52; OR =2.11, 95% CI: 1.67–2.68. Patients with CD44 overexpression exhibited significantly worse overall survival (hazard ratio =1.27; 95% CI: 1.04–1.55. Whole gene profile analysis revealed that CD44 expression was enriched in basal-type breast cancer and correlated with epithelial–mesenchymal transition and cancer stem cell gene profiles. In summary, our analyses indicated that CD44 potentially might be a prognostic marker for breast cancer and thus can serve as a therapeutic target for basal-type breast cancer. Keywords: breast cancer, CD44, survival prediction, meta

  1. Advances with microRNAs in Parkinson’s disease research

    Directory of Open Access Journals (Sweden)

    Ma L

    2013-10-01

    Full Text Available Liuqing Ma,1,2,* Liangming Wei,3,* Fei Wu,2,* Zhenhua Hu,2 Zhenguo Liu,1 Weien Yuan2 1Department of Neurology, Xinhua Hospital affiliated with Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2School of Pharmacy, Shanghai JiaoTong University, Shanghai, People’s Republic of China; 3Research Institute of Micro/Nano Science and Technology, Shanghai JiaoTong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Parkinson’s disease (PD is the second-most common age-dependent neurodegenerative disorder and is caused by severe degeneration of dopaminergic neurons in the substantia nigra pars compacta. Unfortunately, current treatment only targets symptoms and involves dopamine replacement therapy, which does not counteract progressive degeneration. MicroRNAs (miRNAs are a class of small RNA molecules implicated in post-transcriptional regulation of gene expression during development. Recent studies show that miRNAs are playing an important role in the pathophysiology of PD. miRNA-based therapy is a powerful tool with which to study gene function, investigate the mechanism of the disease, and validate drug targets. In this review, we focus on the recent advances of the use of miRNAs in the pathogenesis of PD. Keywords: miRNA, α-synuclein, LRRK2, miRNA-based therapy, pathophysiology

  2. A case of 18p deletion syndrome after blepharoplasty

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    Xu LJ

    2017-01-01

    Full Text Available Li-juan Xu,1 Lv-xian Wu,2 Qing Yuan,3 Zhi-gang Lv,1 Xue-yan Jiang2 1Department of Opthalmology, 2Department of Pediatrics, 3Department of Clinical Laboratory, Jinhua Central Hospital, Jinhua, Zhejiang, People’s Republic of China Objective: The deletion of the short arm of chromosome 18 is thought to be one of the rare chromosomal aberrations. Here, we report a case to review this disease.Case report: The proband is a five-and-a-half-year-old girl who has had phenotypes manifested mainly by ptosis, broad face, broad neck with low posterior hairline, mental retardation, short stature, and other malformations. Chromosomal analysis for her mother showed a normal karyotype. Her father and younger brother were phenotypically normal.Result: Phenotypical features were quite similar throughout other cases and in accordance with the usual phenotype of del(18p suggested within the same cases and among the del(18p cases described. She underwent blepharoplasty, which improved her appearance.Conclusion: 18p deletion syndrome is diagnosed by gene analysis. Plastic surgeries for improving the appearance might be an option for these patients. Keywords: chromosome, deletion, blepharoplasty

  3. High-Precision Attitude Post-Processing and Initial Verification for the ZY-3 Satellite

    Directory of Open Access Journals (Sweden)

    Xinming Tang

    2014-12-01

    Full Text Available Attitude data, which is the important data strongly correlated with the geometric accuracy of optical remote sensing satellite images, are generally obtained using a real-time Extended Kalman Filter (EKF with star-tracker and gyro data for current high-resolution satellites, such as Orb-view, IKONOS, Quickbird,Pleiades, and ZY-3.We propose a forward-backward Unscented Kalman Filter (UKF for post-processing, and the proposed method employs UKF to suppress noise by using an unscented transformation (UT rather than an EKF in a nonlinear attitude system. Moreover, this method makes full use of the collected data in the fixed-interval and computational resources on the ground, and it determines optimal attitude results by forward-backward filtering and weighted smoothing with the raw star-tracker and gyro data collected for a fixed period. In this study, the principle and implementation of the proposed method are described. The post-processed attitude was compared with the on-board attitude, and the absolute accuracy was evaluated by the two methods. One method compares the positioning accuracy of the object space coordinates with the post-processed and on-board attitude data without using ground control points (GCPs. The other method compares the tie-point residuals of the image coordinates after a free net adjustment. In addition, the internal and external parameters of the camera were accurately calibrated before use for an objective evaluation of the attitude accuracy. The experimental results reveal that the accuracy of the post-processed attitude is superior to the accuracy of the on-board processed attitude. This method has been applied to the ZiYuan-3 satellite system for processing the raw star-tracker and gyro data daily.

  4. Translational selection in human: More pronounced in housekeeping genes

    KAUST Repository

    Ma, Lina; Cui, Peng; Zhu, Jiang; Zhang, Zhihua; Zhang, Zhang

    2014-01-01

    by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering

  5. Frontiers in biochip technology

    National Research Council Canada - National Science Library

    Xing, Wan-Li; Cheng, Jing

    2006-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . Haiching Ma, Yuan Wang, Amy S. Pomaybo, and Connie Tsai 2. Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch...

  6. Farmers and Herders Benefit From Bank Loans

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    From 2000 to the end of 2004, the Tibet Branch of Agricultural Bank provided farmers and herders with loans that helped raise their average net income from 1,342 Yuan to 1,863 Yuan during the period.The net increase in income totaled nearly 1.1 billion Yuan.

  7. Wake-up radio systems : design, development, performance evaluation and comparison to conventional medium access control protocols for wireless sensor networks

    OpenAIRE

    Oller i Bosch, Joaquim

    2015-01-01

    During the recent years, the research related to Wake-up Radio (WuR) systems has gained noticeable interest. In WuR systems, a node initiating a communication first sends a Wake-up Call (WuC) by means of its Wake-up Transmitter (WuTx), to the Wake-up Receiver (WuRx) of a remote node to activate it in an on-demand manner. Until the reception of the WuC, the node's MCU and main data transceiver are in sleep mode. Hence, WuR drastically reduce the power required by wireless nodes. This thesis...

  8. The impact of the duration of an untreated episode on improvement of depression and somatic symptoms

    Directory of Open Access Journals (Sweden)

    Hung CI

    2015-08-01

    Full Text Available Ching-I Hung,1,2 Nan-Wen Yu,1,2 Chia-Yih Liu,1,2 Kuan-Yi Wu,1,2 Ching-Hui Yang3 1Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan, 2Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 3Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan Purpose: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD, after the patients had received 4 weeks of pharmacotherapy. Methods: In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS, composed of the depression subscale (DS and the somatic subscale (SS, was used. The SS included the pain subscale (PS and the nonpain somatic subscale (NPSS. Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs of depression and somatic symptoms. Results: Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. Conclusion: A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms. Keywords: early intervention, somatization, treatment response, prognosis, outcome

  9. Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

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    Li HF

    2015-06-01

    Full Text Available Huai-Feng Li,1–3,* Xu-An Wang,1–3,* Shan-Shan Xiang,1–3,* Yun-Ping Hu,1–3 Lin Jiang,1–3 Yi-Jun Shu,1–3 Mao-Lan Li,1–3 Xiang-Song Wu,1–3 Fei Zhang,1–3 Yuan-Yuan Ye,1–3 Hao Weng,1–3 Run-Fa Bao,1–3 Yang Cao,1–3 Wei Lu,1–3 Qian Dong,1–3 Ying-Bin Liu1–3 1Department of General Surgery, 2Laboratory of General Surgery, 3Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Oleanolic acid (OA, a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor prognosis. Unfortunately, the effects of OA on gallbladder carcinoma are unknown. In this study, we investigated the effects of OA on gallbladder cancer cells and the underlying mechanism. The results showed that OA inhibits proliferation of gallbladder cancer cells in a dose-dependent and time-dependent manner on MTT and colony formation assay. A flow cytometry assay revealed apoptosis and G0/G1 phase arrest in GBC-SD and NOZ cells. Western blot analysis and a mitochondrial membrane potential assay demonstrated that OA functions through the mitochondrial apoptosis pathway. Moreover, this drug inhibited tumor growth in nude mice carrying subcutaneous NOZ tumor xenografts. These data suggest that OA inhibits proliferation of gallbladder cancer cells by regulating apoptosis and the cell cycle process. Thus, OA may be a promising drug for adjuvant chemotherapy in gallbladder carcinoma. Keywords: oleanolic acid, gallbladder carcinoma, apoptosis, cell cycle arrest, mitochondrial pathway

  10. Taxonomic notes on Neoperla (Plecoptera: Perlidae) from Sichuan Province of China with the description of two new species.

    Science.gov (United States)

    Li, Weihai; Wang, Ying; Wang, Rongfeng

    2017-01-17

    Species of the perlid genus Neoperla from Sichuan Province, China are reviewed. Two new species are described, Neoperla caii Li & Wang, sp. nov. and N. emeishana Li & Wang, sp. nov. The new species are compared with related congeners. Available types of several known Neoperla species from Sichuan Province were studied and complementary descriptions or brief taxonomic comments are presented for N. bilineata Wu & Claassen, N. chui Wu & Claassen, N. microtumida Wu & Claassen, N. quadrata Wu & Claassen and N. truncata Wu.

  11. 古今中西之間--陳垣與20世紀中國史學%Between the Ancient and the Present and between China and the West:Prof. Chen Yuan and Chinese Historiography in the 20 th Century

    Institute of Scientific and Technical Information of China (English)

    陳智超

    2010-01-01

    Every historian should answer two questions related to each other, i. e. what is the relationship between history and reality and what is that between historiography and reality. Moreover, Chinese historians should answer other two questions also re-lated to each other, namely what is the relationship between China and the West and what is that between Chinese culture and Western culture. Based on their own outlook on the ancient and the present as well as on China and the West, every conscious Chinese historian of the 20 th century was bound to cherish a definite sense of responsi-bility and determined what role they played and what way they chose when taking on this responsibility. The present paper expounds Prof. Chen Yuan’ s answers to the above questions andhis practice concerned with them in the four stages of his lifetime.

  12. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors, supplement to: Dineshram, R; Chandramouli, K; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen (2016): Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors. Global Change Biology, 22(6), 2054-2068

    KAUST Repository

    Dineshram, R; Chandramouli, Kondethimmanahalli; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen

    2016-01-01

    survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae

  13. Post‐Secondary Students Prefer IM to E‐mail for Personal and Social Communication. A review of: Lancaster, Sean, David C. Yen, Albert H. Huang, and Shin‐Yuan Hung. “The Selection of Instant Messaging or E‐mail: College Students’ Perspective for Computer Communication.” Information Management & Computer Security 15.1 (2007: 5‐22.

    Directory of Open Access Journals (Sweden)

    Virginia Wilson

    2008-03-01

    Full Text Available Objective – This study investigates college students’ perceptions of instant messaging (IM and e‐mail for conveying emotions, aiding in relationship building, ease of use, and reliability.Design – A survey consisting of 59 questions was administered to 1,000 college students, resulting in 545 usable responses.Setting – The research took place at a midwestern university in the United States.Subjects – 1,000 Management Information Systems (MIS college students.Methods – A 59‐question survey was distributed to 1,000 MIS students during the 2005 academic year. 545 usable responses were returned. Participation was voluntary. During the pre‐phase of the research, four categories were determined: emotion, relationship, usage, and reliability. Questions were then written for a pilot study using Likert scaling. The post‐research phase involved evaluating the questions linguistically to ensure proper word usage, comprehension, and lack of bias. Main Results – The questions in the section on conveying emotion dealt with how well the two technologies (e‐mail and IM communicated feelings and emotions. While both technologies were acknowledged as being able to communicate more than merely text, IM was clearly preferred for expressing emotion. Fifty‐two percent of the respondents strongly agreed or agreed that they used emoticons (originally symbols created with letters and special characters; later evolving into graphical images produced and made available by IM companies to express emotion in IM, while fewer than 11% agreed or strongly agreed that they did so in e‐mail. More than 70% of the respondents strongly agreed or agreed that their friends used emoticons in IM,while fewer than 14% strongly agreed or agreed that their friends used emoticons in e‐mails. More than 75% of respondents agreed that it is easier to convey emotions in IM than via e‐mail. Analysis on the questions that dealt with the technologies as useful relationship builders again showed a preference for IM. IM was preferred by a greater number of respondents for fostering friendships, improving relationships with friends or team members, building relationships, social interaction, and social networking. This section also found that more than 75% of the respondents felt that IM was more useful than e‐mail when interacting with friends. However, when asked about interacting with co‐workers specifically, only 44% were in agreement. Nearly 32% were neutral on this point, while 24% were in disagreement. It appears that IM is preferred over e‐mail for fostering social and friendly relationships, but is not preferred when the interaction is work‐related and more professional. In terms of use, both technologies were considered easy to learn and use by more than 90% of respondents. In terms of preferred use, more than 60% of respondents use IM for personal and social interaction, while less than 1% uses IM for work‐related activities. Nearly 80% of respondents preferred using e‐mail for work, and nearly 75% preferred using IM for social interaction. Sixty‐three percent of respondents did not agree that IM is just as effective as face‐to‐face meetings, while nearly 75% did not agree that e‐mail can be as effective as meeting face‐to‐face. In the areas of reliability, security, and privacy of IM and e‐mail, respondents perceived e‐mail more favourably. Sixty-four percent of respondents agreed or strongly agreed that IM is very reliable, while 80% of respondents felt the same way about e‐mail. Just over 30% of those questioned agreed that IM is very secure, while more than 50% felt that way about email. However, the gap is narrower when users were queried as to whether or not they worry about security: 13% strongly agreedwith the statement that users do not worry about their security when using IM, while 15% strongly agreed with the statement as it pertained to e‐mail. The same types of questions were asked about perceived privacy. Nearly 50% agreed that their privacy is protected with e‐mail, while just under 35% had the same belief about IM. More than 60% of respondents reported that they do not worry about privacy when emailing, while about 53% of respondents do not worry about privacy with IM. Conclusion – IM was perceived more favourably than e‐mail in 3 of the 4 categories: conveying emotions, building relationships, and ease of use. In the reliability category, e‐mail was perceived more favourably. However, there is a division between social interaction and professional communication. IM is preferred for personal and social relationships, while e‐mail is preferred for work‐related communication. Neither of the technologies is as desirable as face‐to‐face meetings.

  14. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors, supplement to: Dineshram, R; Chandramouli, K; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen (2016): Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors. Global Change Biology, 22(6), 2054-2068

    KAUST Repository

    Dineshram, R

    2016-01-01

    The metamorphosis of planktonic larvae of the Pacific oyster (Crassostrea gigas) underpins their complex life-history strategy by switching on the molecular machinery required for sessile life and building calcite shells. Metamorphosis becomes a survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae might be affected in a future ocean, we examined changes in the proteome of metamorphosing larvae under multiple stressors: decreased pH (pH 7.4), increased temperature (30 °C), and reduced salinity (15 psu). Quantitative protein expression profiling using iTRAQ-LC-MS/MS identified more than 1300 proteins. Decreased pH had a negative effect on metamorphosis by down-regulating several proteins involved in energy production, metabolism, and protein synthesis. However, warming switched on these down-regulated pathways at pH 7.4. Under multiple stressors, cell signaling, energy production, growth, and developmental pathways were up-regulated, although metamorphosis was still reduced. Despite the lack of lethal effects, significant physiological responses to both individual and interacting climate change related stressors were observed at proteome level. The metamorphosing larvae of the C. gigas population in the Yellow Sea appear to have adequate phenotypic plasticity at the proteome level to survive in future coastal oceans, but with developmental and physiological costs.

  15. New opinion on the subtypes of poststroke depression in Chinese stroke survivors

    Directory of Open Access Journals (Sweden)

    Yue Y

    2017-03-01

    Full Text Available Yingying Yue,1,2 Rui Liu,3 Yin Cao,4 Yanfeng Wu,5 Shining Zhang,6 Huajie Li,7 Jijun Zhu,8 Wenhao Jiang,1,2 Aiqin Wu,9 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 2Institute of Psychosomatics, Medical school of Southeast university, Nanjing, 3School of Information Science and Engineering, Southeast University, Nanjing, 4Department of Neurology, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Changzhou, 5Department of Neurology, The Second Affiliated Hospital of Nanjing Medical University, 6Department of Psychiatry, Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 7Department of Neurology, Changzhou First People’s Hospital, Changzhou, 8Department of Neurology, Yancheng Third People’s Hospital, Yancheng, 9Department of Psychosomatics, The Affiliated First Hospital of Suzhou University, Suzhou, People’s Republic of China Aim: Poststroke depression (PSD is the most common complication of stroke. However, some stroke survivors with depression cannot meet the diagnostic criteria of PSD. The aim of this study was to propose the new conception of stroke patients with depression and then make them to receive reasonable diagnosis and treatment. Methods: We first put forward the opinion that the general PSD should consist of PSD disorder (PSDD and PSD symptoms (PSDS according to the Diagnostic and Statistical Manual of Mental Disorder – Fifth Edition (DSM-5 and ZhongDa diagnostic criteria – first edition (ZD-1, respectively. The ZD-1 was established based on the suggestions of 65 Chinese chief doctors considering that the symptoms of PSDS might be different from those of PSDD and the duration of DSM-5 was too strict. Then, 166 stroke inpatients were recruited, and the study was conducted using the diagnosis and classification of PSD to verify the new concept. Results: A total of 24 (14.46% and 80 (48.19% stroke

  16. Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

    Directory of Open Access Journals (Sweden)

    Cui FB

    2014-05-01

    Full Text Available Fang-bo Cui,1,* Qin Liu,1,* Ru-Tian Li,1 Jie Shen,1 Pu-yuan Wu,1 Li-Xia Yu,1 Wen-jing Hu,1 Feng-lei Wu,2 Chun-Ping Jiang,1 Guo-feng Yue,2 Xiao-Ping Qian,1 Xi-Qun Jiang,3 Bao-Rui Liu11The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, 2Nanjing Medical University, 3Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China*These authors contributed equally to this workAbstract: Radiotherapy is the main locoregional control modality for many types of unresectable tumors, including gastric cancer. However, many patients fail radiotherapy due to intrinsic radioresistance of cancer cells, which has been found to be strongly associated with cancer stem cell (CSC-like properties. In this study, we developed a nanoparticle formulation to deliver miR-200c, which is reported to inhibit CSC-like properties, and then evaluated its potential activity as a radiosensitizer. miR-200c nanoparticles significantly augmented radiosensitivity in three gastric cancer cell lines (sensitization enhancement ratio 1.13–1.25, but only slightly in GES-1 cells (1.06. In addition to radioenhancement, miR-200c nanoparticles reduced the expression of CD44, a putative CSC marker, and the percentage of CD44+ BGC823 cells. Meanwhile, other CSC-like properties, including invasiveness and resistance to apoptosis, could be suppressed by miR-200c nanoparticles. CSC-associated radioresistance mechanisms, involving reactive oxygen species levels and DNA repair capacity, were also attenuated. We have demonstrated that miR-200c nanoparticles are an effective radiosensitizer in gastric cancer cells and induce little radiosensitization in normal cells, which suggests that they are as a promising candidate for further preclinical and clinical evaluation

  17. Rural older people had lower mortality after accidental falls than non-rural older people

    Directory of Open Access Journals (Sweden)

    Huang JW

    2017-01-01

    Full Text Available Jen-Wu Huang,1,2 Yi-Ying Lin,2,3 Nai-Yuan Wu,4 Yu-Chun Chen5–7 1Department of Surgery, National Yang-Ming University Hospital, National Yang-Ming University, Yilan, Taiwan; 2Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan; 4Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan; 5Department of Medical Research and Education, National Yang-Ming University Hospital, Yilan, Taiwan; 6Faculty of Medicine and School of Medicine, National Yang-Ming University, Taipei, Taiwan; 7Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan Objective: This study aimed to investigate the mortality rate after falls of rural and non-rural older people and to explore the risk factors of mortality after falls among older people. Patients and methods: This population-based case–control study identified two groups from a nationwide claim database (National Health Insurance Research Database in Taiwan: a rural group and a non-rural group, which included 3,897 and 5,541 older people, respectively, who were hospitalized for accidental falls (The International Classification of Diseases, Ninth Revision, Clinical Modification: E880–E888 during 2006–2009. Both groups were followed up for 4 years after falls. Four-year cumulative all-cause mortality rate after falls was calculated, and the demographic factor, comorbidity, and medications were considered as the potential risk factors of mortality after falls. Results: The rural group had a significantly higher frequency of fall-related hospitalizations (7.4% vs 4.3%, P<0.001, but a lower 4-year cumulative all-cause mortality rate after falls than the non-rural group (8.8% vs 23.4%, P<0.001. After adjusting for age, gender, comorbidity, and medication use, the rural group had

  18. Dual tumor-targeted poly(lactic-co-glycolic acid–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

    Directory of Open Access Journals (Sweden)

    Chen J

    2017-08-01

    Full Text Available Jia Chen,1,2,* Qi Wu,1,* Li Luo,1 Yi Wang,1 Yuan Zhong,1 Han-Bin Dai,1 Da Sun,1,3 Mao-Ling Luo,4 Wei Wu,1 Gui-Xue Wang1 1Key Laboratory for Biorheological Science and Technology, Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University, Chongqing, 2Institute of Laboratory Animals, Sichuan Academy of Medical Science, Sichuan Provincial People’s Hospital, Chengdu, 3Institute of Life Sciences, Wenzhou University, Wenzhou, 4School of Medicine, Wuhan University, Wuhan, China *These authors contributed equally to this work Abstract: Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic-co-glycolic acid (PLGA–polyethylene glycol (PEG–folic acid (FA copolymer was able to self-assemble into nanoparticles with favorable hydrodynamic diameters of around 100 nm and negative surface charge in aqueous solution, which was expected to enhance intracellular antitumor drug delivery by advanced dual tumor-target effects, ie, enhanced permeability and retention induced the passive target, and FA mediated the positive target. Fluorescence-activated cell-sorting and confocal laser-scanning microscopy results confirmed that doxorubicin (model drug loaded into PLGA-PEG-FA nanoparticles was able to be delivered efficiently into tumor cells and accumulated at nuclei. In addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium, and zebrafish-development experiments demonstrated that PLGA-PEG-FA nanoparticles were biocompatible and secure for biomedical applications, even at high polymer concentration (0.1 mg/mL, both in vitro and in vivo. Therefore, PLGA-PEG-FA nanoparticles provide a feasible controlled-release platform for secure and efficient antitumor drug

  19. Proceedings of the 2016 China Cancer Immunotherapy Workshop

    Directory of Open Access Journals (Sweden)

    Bin Xue

    2016-10-01

    Full Text Available Table of contents A1 Proceedings of 2016 China Cancer Immunotherapy Workshop, Beijing, China Bin Xue, Jiaqi Xu, Wenru Song, Zhimin Yang, Ke Liu, Zihai Li A2 Set the stage: fundamental immunology in forty minutes Zihai Li A3 What have we learnt from the anti-PD-1/PD-L1 therapy of advanced human cancer? Lieping Chen A4 Immune checkpoint inhibitors in lung cancer Edward B. Garon A5 Mechanisms of response and resistance to checkpoint inhibitors in melanoma Siwen Hu-Lieskovan A6 Checkpoint inhibitor immunotherapy in lymphoid malignancies Wei Ding A7 Translational research to improve the efficacy of immunotherapy in genitourinary malignancies Chong-Xian Pan A8 Immune checkpoint inhibitors in gastrointestinal malignancies Weijing Sun A9 What’s next beyond PD-1/PDL1? Yong-Jun Liu A10 Cancer vaccines: new insights into the oldest immunotherapy strategy Lei Zheng A11 Bispecific antibodies for cancer immunotherapy Delong Liu A12 Updates on CAR-T immunotherapy Michel Sadelain A13 Adoptive T cell therapy: personalizing cancer treatment Cassian Yee A14 Immune targets and neoantigens for cancer immunotherapy Rongfu Wang A15 Phase I/IIa trial of chimeric antigen receptor modified T cells against CD133 in patients with advanced and metastatic solid tumors Meixia Chen, Yao Wang, Zhiqiang Wu, Hanren Dai, Can Luo, Yang Liu, Chuan Tong, Yelei Guo, Qingming Yang, Weidong Han A16 Cancer immunotherapy biomarkers: progress and issues Lisa H. Butterfield A17 Shaping of immunotherapy response by cancer genomes Timothy A. Chan A18 Unique development consideration for cancer immunotherapy Wenru Song A19 Immunotherapy combination Ruirong Yuan A20 Immunotherapy combination with radiotherapy Bo Lu A21 Cancer immunotherapy: past, present and future Ke Liu A22 Breakthrough therapy designation drug development and approval Max Ning A23 Current European regulation of innovative oncology medicines: opportunities for immunotherapy Harald Enzmann, Heinz Zwierzina

  20. Association between muscle atrophy/weakness and health care costs and utilization among patients receiving total knee replacement surgery: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Chen SY

    2013-08-01

    Full Text Available Shih-Yin Chen,1 Ning Wu,1 Yuan-Chi Lee,1 Yang Zhao21Health Economics and Epidemiology, Evidera, Lexington, Massachusetts, 2Health Economics and Outcomes Research, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USAPurpose: The aim of the study reported here was to examine health care resource utilization, costs, and risk of rehospitalization for total knee replacement (TKR patients with and without muscle atrophy/weakness (MAW.Patients and methods: Individuals aged 50–64 years with commercial insurance or 65+ years with Medicare Supplemental Insurance (Medicare who had a hospitalization for TKR between January 1, 2006 and September 30, 2009 were identified from a large US claims database. First hospitalization for TKR was defined as the index stay. All patients were classified into three cohorts according to when MAW was diagnosed relative to TKR: pre-MAW, post-MAW, and no MAW. The association between MAW and health care costs over the 12-month post-index period and the probability of rehospitalization were assessed via multivariate regressions.Results: The study sample included 53,696 Medicare and 46,058 commercial insurance TKR patients. Controlling for cross-cohort differences, both the pre- and post-MAW cohorts had significantly higher total health care costs (Medicare US$4,201 and US$9,404 higher, commercial insurance US$2,737 and US$6,640 higher, respectively than the no MAW cohort (all P < 0.05. The post-MAW cohort in both populations was also more likely to have any all-cause or replacement-related rehospitalization compared with the no MAW cohort.Conclusion: Among US patients undergoing TKR, those with MAW had higher health care utilization and costs than patients without MAW.Keywords: rehospitalization, resource utilization, Medicare, health insurance, USA

  1. Immobilization of collagen peptide on dialdehyde bacterial cellulose nanofibers via covalent bonds for tissue engineering and regeneration

    Directory of Open Access Journals (Sweden)

    Wen XX

    2015-07-01

    Full Text Available Xiaoxiao Wen,1 Yudong Zheng,1 Jian Wu,2 Lu-Ning Wang,1 Zhenya Yuan,1 Jiang Peng,3 Haoye Meng3 1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, People’s Republic of China; 2Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Soochow, People’s Republic of China; 3Institute of Orthopedics, Chinese PLA General Hospital, Beijing, People’s Republic of China Abstract: Bacterial cellulose (BC is an alternative nanostructured biomaterial to be utilized for a wide range of biomedical applications. Because of its low bioactivity, which restricted its practical application, collagen and collagen hydrolysate were usually composited into BC. It is necessary to develop a new method to generate covalent bonds between collagen and cellulose to improve the immobilization of collagen on BC. This study describes a facile dialdehyde BC/collagen peptide nanocomposite. BC was oxidized into dialdehyde bacterial cellulose (DBC by regioselective oxidation, and then composited with collagen peptide (Col-p via covalent bonds to form Schiff’s base type compounds, which was demonstrated by the results of microstructures, contact angle, Col-p content, and peptide-binding ratio. The peptide-binding ratio was further affected by the degree of oxidation, pH value, and zeta potential. In vitro desorption measurement of Col-p suggested a controlled release mechanism of the nanocomposite. Cell tests indicated that the prepared DBC/Col-p composite was bioactive and suitable for cell adhesion and attachment. This work demonstrates that the DBC/Col-p composite is a promising material for tissue engineering and regeneration. Keywords: bacterial cellulose, dialdehyde cellulose, collagen peptide, composite materials, cytoactivity 

  2. Polyethylene glycol–polylactic acid nanoparticles modified with cysteine–arginine–glutamic acid–lysine–alanine fibrin-homing peptide for glioblastoma therapy by enhanced retention effect

    Directory of Open Access Journals (Sweden)

    Wu J

    2014-11-01

    Full Text Available Junzhu Wu,1,2,* Jingjing Zhao,1,3,* Bo Zhang,1 Yong Qian,1 Huile Gao,1 Yuan Yu,1 Yan Wei,1 Zhi Yang,1 Xinguo Jiang,1 Zhiqing Pang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 2School of Pharmacy, Dali University, Xiaguan, 3School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Abstract: For a nanoparticulate drug-delivery system, crucial challenges in brain-glioblastoma therapy are its poor penetration and retention in the glioblastoma parenchyma. As a prevailing component in the extracellular matrix of many solid tumors, fibrin plays a critical role in the maintenance of glioblastoma morphology and glioblastoma cell differentiation and proliferation. We developed a new drug-delivery system by conjugating polyethylene glycol–polylactic acid nanoparticles (NPs with cysteine–arginine–glutamic acid–lysine–alanine (CREKA; TNPs, a peptide with special affinity for fibrin, to mediate glioblastoma-homing and prolong NP retention at the tumor site. In vitro binding tests indicated that CREKA significantly enhanced specific binding of NPs with fibrin. In vivo fluorescence imaging of glioblastoma-bearing nude mice, ex vivo brain imaging, and glioblastoma distribution demonstrated that TNPs had higher accumulation and longer retention in the glioblastoma site over unmodified NPs. Furthermore, pharmacodynamic results showed that paclitaxel-loaded TNPs significantly prolonged the median survival time of intracranial U87 glioblastoma-bearing nude mice compared with controls, Taxol, and NPs. These findings suggested that TNPs were able to target the glioblastoma and enhance retention, which is a valuable strategy for tumor therapy. Keywords: CREKA peptide, nanoparticles, retention effect, paclitaxel, glioblastoma

  3. Estimating net surface shortwave radiation from Chinese geostationary meteorological satellite FengYun-2D (FY-2D) data under clear sky.

    Science.gov (United States)

    Zhang, Xiaoyu; Li, Lingling

    2016-03-21

    Net surface shortwave radiation (NSSR) significantly affects regional and global climate change, and is an important aspect of research on surface radiation budget balance. Many previous studies have proposed methods for estimating NSSR. This study proposes a method to calculate NSSR using FY-2D short-wave channel data. Firstly, a linear regression model is established between the top-of-atmosphere (TOA) broadband albedo (r) and the narrowband reflectivity (ρ1), based on data simulated with MODTRAN 4.2. Secondly, the relationship between surface absorption coefficient (as) and broadband albedo (r) is determined by dividing the surface type into land, sea, or snow&ice, and NSSR can then be calculated. Thirdly, sensitivity analysis is performed for errors associated with sensor noise, vertically integrated atmospheric water content, view zenith angle and solar zenith angle. Finally, validation using ground measurements is performed. Results show that the root mean square error (RMSE) between the estimated and actual r is less than 0.011 for all conditions, and the RMSEs between estimated and real NSSR are 26.60 W/m2, 9.99 W/m2, and 23.40 W/m2, using simulated data for land, sea, and snow&ice surfaces, respectively. This indicates that the proposed method can be used to adequately estimate NSSR. Additionally, we compare field measurements from TaiYuan and ChangWu ecological stations with estimates using corresponding FY-2D data acquired from January to April 2012, on cloud-free days. Results show that the RMSE between the estimated and actual NSSR is 48.56W/m2, with a mean error of -2.23W/m2. Causes of errors also include measurement accuracy and estimations of atmospheric water vertical contents. This method is only suitable for cloudless conditions.

  4. WORD BORROWING AND VOCABULARY EXCHANGE IN TURKISH DIALECTS: CASE OF OSMANIYE TATAR DIALECT / TÜRK LEHÇELERI ARASINDA SÖZCÜK ALIS VERISI VE SÖZ VARLIĞI DEĞISIMI: OSMANIYE TATAR AĞZI ÖRNEĞI

    Directory of Open Access Journals (Sweden)

    Dr. Ercan ALKAYA

    2008-08-01

    Full Text Available The basic vocabulary which constructs the main vocabulary of alanguage is the word that is transferred from generation to generation in everylanguage, has importance of first degree and reflects important concepts aboutmankind and his environment. The words dealing with body, color, andconcepts about nature, animal names, numbers, and the most used verbs,words of holy concepts and persons and traditions consist of basic vocabularyof a language. In this study, the change in vocabulary of Kazan Tatar Turks, whomigrated from Kazan, Orenburg and Samara regions and inhabited in thevillage of Osmaniye of Çifteler, Eskisehir after 1884, was investigated. Thedialects of Tatar Turks who migrated from Kazan and its surrounding areawere affected by the local people who have been living in that region. Thoughthey still protect phonetical and morphological features of their language, itwas affected by the local dialect and Turkey Turkish.The main changes in the vocabulary of Tatar Turks in Osmaniye villagewere evaluated under several headings.

  5. Příprava referencí optických kmitočtů na bázi fotonických vláken plněných absorpčními plyny

    Czech Academy of Sciences Publication Activity Database

    Hrabina, Jan; Mikel, Břetislav; Holá, Miroslava; Číp, Ondřej; Lazar, Josef

    2016-01-01

    Roč. 61, 4-5 (2016), s. 98-100 ISSN 0447-6441 R&D Projects: GA ČR GA15-18430S; GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : frequency stabilization of lasers * photonics crystal fibers * absorption cells Subject RIV: BH - Optics, Masers, Lasers

  6. ADDITIONS FROM TARSUS REGION TO THE DICTIONARY OF COMPILATION (DERLEME SOZLUGU AND THE DICTIONARY OF MERSIN DIALECT (MERSIN AGZI SOZLUGU DERLEME SÖZLÜĞÜ VE MERSİN AĞZI SÖZLÜĞÜ’NE TARSUS YÖRESİNDEN KATKILAR

    Directory of Open Access Journals (Sweden)

    Mustafa TOKER

    2011-09-01

    Full Text Available Local dialects have begun to be forgotten rapidly following the mass communication media entered in lives. This situation deeply impacts dialects in terms of sound (phonetics, structure (morphology, and repertory of words (vocabulary. Turkish dialects are approaching the grammarrules of the written language by the impact of the mass communication media and facing weakening in terms of vocabulary by the time passes. In other words, local dialects are approaching the written language be ingunable to protect itself against the pressure of the written language and vocabulary is exposed to wear stemming from not beingused. These words which are facing extinction in the dialects should be registered in no time. Up to this time in this subject many studies belonging to various regions of our country have been done. This study was prepared as an addition to those studies. Kitle iletişim araçlarının insan hayatına girmesiyle yerel diller (ağızlar hızla unutulmaya başladı. Bu durum, ağızları gerek ses (fonetik, gerek yapı (morfoloji, ve gerekse de söz varlığı (vocabulary açısından derinden etkilemektedir. Türkiye Türkçesi ağızları bu kitle iletişim araçlarının etkisiyle yazı dilinin gramer kurallarına yakınlaşmakta, söz varlığı açısından da gün geçtikçe zayıflamaktadır. Başka bir ifadeyle, yerel diller yazı dilinin ağırlığı altında kendisini muhafaza edemeyerek yazı diline yaklaşmakta, söz varlığı da kullanılmaya kullanılmaya daralmaktadır. Ağızlardaki yok olma tehlikesiyle karşı karşıya olan bu kelimelerin bir an önce kayda geçirilmesi gerekmektedir. Bu zamana kadar konuyla ilgili olarak ülkemizin çeşitli yörelerine ait pek çok çalışma yapılmıştır. Bu çalışma da bu çalışmalara bir katkı olmak üzere hazırlanmıştır.

  7. Detekční systémy pro měření vyzařování vysokoteplotního plazmatu tokamaku COMPASS na bázi rychlých bolometrů a měkkých rentgenových detektorů

    OpenAIRE

    Vácha, Miroslav

    2010-01-01

    Title: Detection systems for measurements of high-temperature plasma radiation on the COMPASS tokamak by fast bolometers and soft X-ray detectors Author: Miroslav Vácha Department: Institute of Particle and Nuclear Physics Supervisor: Mgr. Vladimír Weinzettl, Ph.D., Institute of Plasma Physics AS CR, v.v.i. Supervisor's e-mail address: Abstract: Multi-channel spectroscopic diagnostics on the COMPASS tokamak com- prising AXUV-based bolometers, soft X-ray (SXR) and visible light...

  8. Detekční systémy pro měření vyzařování vysokoteplotního plazmatu tokamaku COMPASS na bázi rychlých bolometrů a měkkých rentgenových detektorů

    OpenAIRE

    Vácha, Miroslav

    2009-01-01

    Title: Detection systems for measurements of high-temperature plasma radiation on the COMPASS tokamak by fast bolometers and soft X-ray detectors Author: Miroslav Vácha Department: Institute of Particle and Nuclear Physics Supervisor: Mgr. Vladimír Weinzettl, Ph.D., Institute of Plasma Physics AS CR, v.v.i. Supervisor's e-mail address: Abstract: Multi-channel spectroscopic diagnostics on the COMPASS tokamak com- prising AXUV-based bolometers, soft X-ray (SXR) and visible light...

  9. Dva dětské pohřby na pozdně halštatském až časně laténském sídlišti v Dobrovízi, okr. Praha-západ

    Czech Academy of Sciences Publication Activity Database

    Psohlavcová, Monika; Stránská, Petra; Trojánková, Olga

    2017-01-01

    Roč. 21, č. 2 (2017), s. 833-845 ISSN 1214-3553 Institutional support: RVO:67985912 Keywords : infant grave * Late Hallstatt/Early La Tène settlement * import Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  10. Role rodiny a školy v reprodukci vzdělanostních nerovností. Sociologický pohled na úlohu víceletých gymnázií ve světle výzkumu PISA 2000

    Czech Academy of Sciences Publication Activity Database

    Matějů, Petr; Straková, Jana

    2003-01-01

    Roč. 39, č. 5 (2003), s. 625-652 ISSN 0038-0288 R&D Projects: GA ČR(CZ) GA403/03/0340 Institutional research plan: CEZ:AV0Z7028912 Keywords : education al inequalities * family * school Subject RIV: AO - Sociology, Demography Impact factor: 0.063, year: 2003

  11. Biodegradabilní kompozitní materiály na bázi pšeničného B-škrobu s upotřebním v zemědělství

    Czech Academy of Sciences Publication Activity Database

    Šárka, E.; Kruliš, Zdeněk; Kotek, Jiří; Růžek, L.; Koláček, J.; Hrušková, K.; Bubník, Z.

    2011-01-01

    Roč. 127, č. 12 (2011), s. 402-405 ISSN 1210-3306 R&D Projects: GA ČR GA525/09/0607 Institutional research plan: CEZ:AV0Z40500505 Keywords : wheat starch * B-starch * acetylated starch Subject RIV: JI - Composite Materials Impact factor: 0.645, year: 2009 http://www.cukr-listy.cz/on_line/2011/PDF/402-405.pdf

  12. Problematika výuky sexuální výchovy na druhém stupni základních škol a nižších třídách gymnázií

    OpenAIRE

    VOJÍKOVÁ, Klára

    2012-01-01

    The main topic of this thesis is to map the current state of teaching sex education in primary schools and grammar schools. First, I focus on the theoretical treatment of the subject when I am describing the appropriate age to teach, the content of sex education and why education is so important in schools. In the second part of my thesis I process data obtained at several schools using questionnaires. I am trying to find out what are the most common sources of information about sex education...

  13. Monitorování radiace v časné fázi nehody na jaderném zařízení - analýza všech typů měření použitelných pro korekci modelových předpovědí

    Czech Academy of Sciences Publication Activity Database

    Pecha, Petr; Kuča, P.; Češpírová, I.; Hofman, Radek

    2011-01-01

    Roč. 3, č. 2 (2011), s. 102-125 ISSN 1803-568X R&D Projects: GA MV(CZ) VG20102013018 Institutional research plan: CEZ:AV0Z10750506 Keywords : radiation protection * monitoring network * nuclear emergency Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2012/AS/pecha-radiation monitoring in the early phase of an accident at a nuclear facility.pdf

  14. Wpływ estrogenów na stężenie N-terminalnego propeptydu kolagenu typu I w płynie uzyskanym z przestrzennych hodowli ludzkich fibroblastów powięzi łonowo-cewkowej prowadzonych na siatkach polipropylenowych stosowanych w uroginekologii operacyjnej

    Directory of Open Access Journals (Sweden)

    Jacek Tomaszewski

    2010-02-01

    Full Text Available Objectives: Polypropylene meshes are widely used for surgical treatment of stress urinary incontinence(SUI and pelvic organ prolapse (POP. Synthesis and deposition of collagen induced by an inserted implant arelargely controlled by oestrogens. The aim of the study was to assess the rate of collagen type I (Col I synthesisby pubo-cervical fascia (PCF fibroblasts cultured with mono- or multifilament polypropylene meshes in thepresence of oestrogens. Material and Methods: Specimens of PCF were obtained during a surgical procedure from a 56-year-old womansuffering from SUI and POP. Fibroblasts were cultured with mono- or multifilament meshes and exposed to17β-oestradiol, oestriol or phytoestrogen daidzein. The cultures were run for 216 hrs and the media were replaced every 72 hrs. Procollagen type 1 N-terminal propeptide (PINP, a marker of Col I biosynthesis, was assessedin culture media by radioimmunoassay. Results: The biosynthesis of Col I was more abundant in the presence of monofilament than multifilamentmeshes. Fibroblasts exposed to oestriol or daidzein produced more Col I than those treated with oestradiol,regardless of the mesh applied. In the presence of monofilament mesh the rate of Col I synthesis induced byoestriol and daidzein increased persistently until the end of the experiment, whereas the peak concentration ofPINP in cultures treated with oestradiol was observed between 72 hrs and 144 hrs. In the presence of multifilamentmesh the rate of Col I production dropped after 144 hrs in all cultures. Conclusions: PCF fibroblasts produce more Col I when cultured on monofilament than on multifilamentmesh. This process may be enhanced by oestriol and phytoestrogens.

  15. Studium fragmentací iontů Ne s primární energií 400 MeV/n za různými materiály stínění pomocí detektorů stop v pevné fázi

    Czech Academy of Sciences Publication Activity Database

    Mrázová, Zlata; Jadrníčková, Iva; Brabcová, Kateřina; Spurný, František

    2010-01-01

    Roč. 18, 7/8 (2010), s. 233-234 ISSN 1210-7085 R&D Projects: GA AV ČR KJB100480901; GA ČR GA205/09/0171 Institutional research plan: CEZ:AV0Z10480505 Keywords : irradiation * LET * energy spectra Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  16. The Analysis of the Learning Strategies Utilized By Students in Music Class in Terms of Some Psychosocial Variables (Öğrencilerin Kullandığı Müziği Öğrenme Stratejilerinin Bazı Psikososyal Değişkenler Bakımından Analizi

    Directory of Open Access Journals (Sweden)

    Zeynep SEVER

    2011-10-01

    Full Text Available The aim of the study was to bring up learning strategies in music used by 4th, 5th and 6th graders in primary schools in terms of some psychosocial variables. This study is important as it lights the way for the future of our education system and specially strategy teaching in music. The problems and their possible solutions faced during learning of the music were represented. The Sample of this study was composed of totally 200, 4th, 5th and 6th graders in two different primary schools from İzmir-Bornova. The method of the study was Survey model. The opinions of the students regarding their strategies of learning music were gathered by the triple Likert type scale called “Scale for Strategies of Learning Music” which was developed by Kocabaş (1998b. The data analysis was computed under SSPS 15.0 program by using T-test and one way variance. The reliability of the scale of this study was 0,83. As a result of this study, it was observed that gender; school types, the existence of musical education outsources, a person in the family having musical background or playing a musical instrument were effective on the opinions about the strategies followed and used by students during learning music.

  17. Rozdíly v klinickém obraze a laboratorních nálezech v časné fázi aseptického zánětu CNS dle vyvolávajícího agens

    Czech Academy of Sciences Publication Activity Database

    Heinige, P.; Fajt, M.; Šilhánková, I.; Halašková, P.; Jiroušová, M.; Matějčková, Eva; Ješina, Pavel

    2006-01-01

    Roč. 61, č. 5 (2006), s. 273-273 ISSN 0069-2328. [Český pediatrický kongres s mezinárodní účastí /7./. 08.06.2006-11.06.2006, Praha] Keywords : CNS * aseptic inflammation Subject RIV: FG - Pediatrics

  18. Re?bus disainivõistlus ehk noored innovaatorid bussirevolutsiooni otsinguil

    Index Scriptorium Estoniae

    2005-01-01

    2005. a. algul agentuuri APCI (Agence pour la Promotion de la Creation Industrielle) poolt korraldatud disainivõistlusest Re?bus. Eestist valiti 30 finalisti hulka büroo ZiZi & YoYo töö. Edukamad võistlustööd olid juuni algul väljas rahvusvahelise ühistranspordi assotsiatsiooni (UITP) 56. kongressil Roomas

  19. Keeping Tradition

    NARCIS (Netherlands)

    Zenhong, C.; Buwalda, P.L.

    2011-01-01

    Chinese dumplings such as Jiao Zi and Bao Zi are two of the popular traditional foods in Asia. They are usually made from wheat flour dough (rice flour or starch is sometimes used) that contains fillings. They can be steamed, boiled and fried and are consumed either as a main meal or dessert. As

  20. Velocity Spectra in the Unstable Planetary Boundary Layer

    DEFF Research Database (Denmark)

    Højstrup, Jørgen

    1982-01-01

    Models for velocity spectra of all three components in the lower half of the unstable PBL are presented. The model spectra are written as a sum of two parts, nS(n) = A(fi, z/zi)w*2 + B(f, z/zi)u*02, a mixed layer part with a stability dependence, and a surface layer part without stability...

  1. Trend on teada, või kuidas? / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-

    1999-01-01

    Sisustusmess "Habitare'99" Helsingis. Praegune sisekujundusmood. Eestist olid messil ZiZi kodutekstiilid, Steel Line'i toodetud Tarmo Luisu lambid, kataloogi andmetel firmad Majestic ja Päikesedekoori OÜ. Noorte mööblidisainivõistluse võitsid Touko Korhonen ja Simo Puntila. Hindaja inglise disainiprofessor Ron Arad. Üks Soome Sisearhitektide Liidu kahest aastapreemiast Ben af Schultenile

  2. Täna kell 19.30 avatakse reisisadama endises politseimajas...

    Index Scriptorium Estoniae

    2005-01-01

    Ranna-ala arenguvõimalusi tutvustav näitus "Tagasi mere juurde. Mereõhk teeb vabaks", linnadevahelise projekti "Grands Travaux" osa. Väljapaneku on koostanud Tallinna linnavalitsusse ja AS Tallinna Sadam tellimusel disainibüroo ZiZi & YoYo

  3. ANALYSIS AND CORRECTION OF SYSTEMATIC HEIGHT MODEL ERRORS

    Directory of Open Access Journals (Sweden)

    K. Jacobsen

    2016-06-01

    Full Text Available The geometry of digital height models (DHM determined with optical satellite stereo combinations depends upon the image orientation, influenced by the satellite camera, the system calibration and attitude registration. As standard these days the image orientation is available in form of rational polynomial coefficients (RPC. Usually a bias correction of the RPC based on ground control points is required. In most cases the bias correction requires affine transformation, sometimes only shifts, in image or object space. For some satellites and some cases, as caused by small base length, such an image orientation does not lead to the possible accuracy of height models. As reported e.g. by Yong-hua et al. 2015 and Zhang et al. 2015, especially the Chinese stereo satellite ZiYuan-3 (ZY-3 has a limited calibration accuracy and just an attitude recording of 4 Hz which may not be satisfying. Zhang et al. 2015 tried to improve the attitude based on the color sensor bands of ZY-3, but the color images are not always available as also detailed satellite orientation information. There is a tendency of systematic deformation at a Pléiades tri-stereo combination with small base length. The small base length enlarges small systematic errors to object space. But also in some other satellite stereo combinations systematic height model errors have been detected. The largest influence is the not satisfying leveling of height models, but also low frequency height deformations can be seen. A tilt of the DHM by theory can be eliminated by ground control points (GCP, but often the GCP accuracy and distribution is not optimal, not allowing a correct leveling of the height model. In addition a model deformation at GCP locations may lead to not optimal DHM leveling. Supported by reference height models better accuracy has been reached. As reference height model the Shuttle Radar Topography Mission (SRTM digital surface model (DSM or the new AW3D30 DSM, based on ALOS

  4. Data mining and frequency analysis for licorice as a "Two-Face" herb in Chinese Formulae based on Chinese Formulae Database.

    Science.gov (United States)

    Guo, Jianming; Shang, Erxin; Zhao, Jinlong; Fan, Xinsheng; Duan, Jinao; Qian, Dawei; Tao, Weiwei; Tang, Yuping

    2014-09-25

    Liquorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L., Leguminosae. Licorice is described as 'National Venerable Master' in Chinese medicine and plays paradoxical roles, i.e. detoxification/strengthen efficacy and inducing/enhancing toxicity. Therefore, licorice was called "Two-Face" herb in this paper. The aim of this study is to discuss the paradoxical roles and the perspective usage of this "Two-Face" herb using data mining and frequency analysis. More than 96,000 prescriptions from Chinese Formulae Database were selected. The frequency and the prescription patterns were analyzed using Microsoft SQL Server 2000. Data mining methods (frequent itemsets) were used to analyze the regular patterns and compatibility laws of the constituent herbs in the selected prescriptions. The result showed that licorice (Radix glycyrrhizae) was the most frequently used herb in Chinese Formulae Database, other frequently used herbs including Radix Angelicae Sinensis (Dang gui), Radix et rhizoma ginseng (Ren shen), etc. Toxic herbs such as Radix aconiti lateralis praeparata (Fu zi), Rhizoma pinelliae (Ban xia) and Cinnabaris (Zhu sha) are top 3 herbs that most frequently used in combination with licorice. Radix et rhizoma ginseng (Ren shen), Poria (Fu ling), Radix Angelicae Sinensis (Dang gui) are top 3 nontoxic herbs that most frequently used in combination with licorice. Moreover, Licorice was seldom used with sargassum (Hai Zao), Herba Cirsii Japonici (Da Ji), Euphorbia kansui (Gan Sui) and Flos genkwa (Yuan Hua), which proved the description of contradictory effect of Radix glycyrrhizae and these herbs as recorded in Chinese medicine theory. This study showed the principle pattern of Chinese herbal drugs used in combination with licorice or not. The principle patterns and special compatibility laws reported here could be useful and instructive for scientific usage of licorice in clinic application. Further pharmacological and chemical researches are

  5. Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation.

    Science.gov (United States)

    Zhang, Xiaobing; van den Pol, Anthony N

    2017-05-26

    The neuronal substrate for binge eating, which can at times lead to obesity, is not clear. We find that optogenetic stimulation of mouse zona incerta (ZI) γ-aminobutyric acid (GABA) neurons or their axonal projections to paraventricular thalamus (PVT) excitatory neurons immediately (in 2 to 3 seconds) evoked binge-like eating. Minimal intermittent stimulation led to body weight gain; ZI GABA neuron ablation reduced weight. ZI stimulation generated 35% of normal 24-hour food intake in just 10 minutes. The ZI cells were excited by food deprivation and the gut hunger signal ghrelin. In contrast, stimulation of excitatory axons from the parasubthalamic nucleus to PVT or direct stimulation of PVT glutamate neurons reduced food intake. These data suggest an unexpected robust orexigenic potential for the ZI GABA neurons. Copyright © 2017, American Association for the Advancement of Science.

  6. Categorizing renal oncocytic neoplasms on core needle biopsy: a morphologic and immunophenotypic study of 144 cases with clinical follow-up. Alderman MA, Daignault S, Wolf JS Jr, Palapattu GS, Weizer AZ, Hafez KS, Kunju LP, Wu AJ. Hum Pathol.September 2016;55:1-10.

    Science.gov (United States)

    Kryvenko, Oleksandr N

    2017-06-01

    There is limited literature on renal oncocytic neoplasms diagnosed on core biopsy. All renal oncocytic neoplasm core biopsies from 2006 to 2013 were, retrospectively, reviewed. Morphologic features and an immunohistochemical panel of CK7, c-KIT, and S100A1 were assessed. Concordance with resection diagnosis, statistical analysis including a random forest classification, and follow-up were recorded. The postimmunohistochemical diagnoses of 144 renal oncocytic core biopsies were favor oncocytoma (67%), favor renal cell carcinoma (RCC) (12%), and cannot exclude RCC (21%). Diagnosis was revised following immunohistochemistry in 7% of cases. The most common features for oncocytoma (excluding dense granular cytoplasm) were nested architecture, edematous stroma, binucleation and tubular architecture; the most common features for favor RCC were sheet-like architecture, nuclear pleomorphism, papillary architecture, and prominent cell borders. High nuclear grade, necrosis, extensive papillary architecture, raisinoid nuclei, and frequent mitoses were not seen in oncocytomas. Comparing the pathologist and random forest classification, the overall out-of-bag estimate of classification error dropped from 23% to 13% when favor RCC and cannot exclude RCC was combined into 1 category. Resection was performed in 19% (28 cases) with a 94% concordance (100% of favor RCC biopsies and 90% of cannot exclude RCC biopsies confirmed as RCC; 83% of favor oncocytomas confirmed); ablation in 23%; and surveillance in 46%. Follow-up was available in 92% (median follow-up, 33 months) with no adverse outcomes. Renal oncocytic neoplasms comprise a significant subset (16%) of all core biopsies, and the majority (78%) can be classified as favor oncocytoma or favor RCC. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Commentary on "tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl) nitrosamine as the basis for urothelial cell carcinogenesis." He Z, Kosinska W, Zhao ZL, Wu XR, Guttenplan JB, Department of Basic Science, New York University Dental College, NY, USA.: Mutat Res 2012;742(1-2):92-5 [Epub 2011 Dec 4].

    Science.gov (United States)

    Scherr, Douglas S

    2014-02-01

    Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke. Of the carcinogens tested in mouse chemical carcinogenesis models, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is one that reproducibly causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. However, the basis for such a high-level tissue-specificity has not been explored. Using mutagenesis in lacI (Big Blue™) mice, we show here that BBN is a potent mutagen and it causes high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. After a 2-6-week treatment of 0.05% BBN in the drinking water, mutagenesis in urothelial cells of male and female mice was about two orders of magnitude greater than the spontaneous mutation background. In contrast, mutagenesis in smooth muscle cells of the urinary bladder was about five times lower than in urothelial tissue. No appreciable increase in mutagenesis was observed in kidney, ureter, liver or forestomach. In lacI (Big Blue™) rats, BBN mutagenesis was also elevated in urothelial cells, albeit not nearly as profoundly as in mice. This provides a potential explanation as to why rats are less prone than mice to the formation of aggressive form of bladder cancer induced by BBN. Our results suggest that the propensity to BBN-triggered mutagenesis of urothelial cells underlies its heightened susceptibility to this carcinogen and that mutagenesis induced by BBN represents a novel model for initiation of bladder carcinogenesis. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. The capital investment and electricity cost of 2 x 600 MW PWR nuclear power plant in China

    International Nuclear Information System (INIS)

    Li Zhihua; Xing Leiming

    1990-01-01

    The capital investment and electricity cost of 2 x 600 MW PWR nuclear power plant in China are studied. If the rate of interest R 1 and of escalation R 2 are 7.2% and 10.0% respectively for RMB and the rate of interest R 1 and of escalation R 2 are 6.5% and 2.0% respectively for MK, the total investment is 9270 M RMB Yuan, the Specific investment is 7320 RMB Yuan/kW, the average selling electricity cost is 0.16 RMB Yuan/(kW·h). If the selling electricity price is 0.24 RMB Yuan/(kW·h), the rate of inner return is 7.7%, the dynamic return period is 13 years, the national income is 15800 M RMB Yuan, the profit of nuclear power plant after taxation is 6800 M RMB Yuan

  9. Anti-tumor activity of polysaccharides extracted from Senecio ...

    African Journals Online (AJOL)

    *, Bao Zhang, Mingming Han, Xin Jin, Liyuan Sun and Tao Li. Department of ..... Yang J, Li X, Xue Y, Wang N, Liu W. Anti-hepatoma activity and mechanism of corn ... Peng W, Wu JG, Jiang YB, Liu YJ, Sun T, Wu N, Wu CJ. Antitumor activity of ...

  10. Committees

    Science.gov (United States)

    2012-11-01

    -RESIGA Politehnica University of Timisoara Romania Kazuhiro TANAKA Kyushu Institute of Technology Japan Yoshinobu TSUJIMOTO Osaka University Japan Local Organizing Committee Chairman Yulin WU Tsinghua University Beijing Executive Chairman Zhengwei WANG Tsinghua University Beijing Members Shuliang CAO Tsinghua University Beijing Cichang CHEN South West University of Petroleum Chengdu Hongxun CHEN Shanghai University Shanghai Jiang DAI China Sanxia General Co Yichang Huashu DOU National University of Singapore Singapore Fengqin HAN Huanan University of Sci & Tech Guangzhou Kun LI Hefei Inst of General Machinery Hefei Rennian LI Lanzhou University of Sci & Tech Lanzhou Wanhong LI National Natural Science Foundation of China Beijing Chao LIU Yangzhou University Yangzhou Li LU China Inst of Water Resources and Hydropower Research Beijing Xingqi LUO Xi'an University of Tech Xi'an Zhenyue MA Dalian University of Sci & Tech Dalian Jiegang MU Zhejiang University of Tech Hangzhou Daqing QIN Harbin Electric Machinery Group Harbin Fujun WANG China Agriculture University Beijing Guoyu WANG Beijing Institute of Technology (BIT) Beijing Leqin WANG Zhejiang University Hangzhou Yuzhen WU NERCSPV Beijing Hongyuan XU Tsinghua University Beijing Jiandong YANG Wuhan University Wuhan Minguan YANG Jiangsu University Zhenjiang Shouqi YUAN Jiangsu University Zhenjiang Lefu ZHANG Harbin Electric Machinery Group Harbin Lixiang ZHANG Yunnan University of Sci & Tech Kunming Shengchang ZHANG Zhejiang University of Tech Hangzhou Kun ZHAO China Water & Electric Consulting Corp Beijing Yuan ZHENG Hehai University Nanjing Jianzhong ZHOU Huazhong University of Sci & Tech Wuhan Lingjiu ZHOU China Agriculture University Beijing Hongwu ZHU China Petroleum University Beijing Zuchao ZHU Zhejiang Sci-Tech University Hangzhou Secretaries Shuhong LIU (Academic), liushuhong@tsinghua.edu.cn Xianwu LUO (Registration), luoxw@tsinghua.edu.cn Baoshan ZHU (Finance), bszhu@mail.tsinghua.edu.cn

  11. 「覆盆子」の生薬学的研究(第1報): 韓国産「覆盆子」の基源(I)

    OpenAIRE

    難波, 恒雄; 小松, かつ子; 小野, 淳子; 鳴橋, 直弘; 御影, 雅幸

    1986-01-01

    "Fu-pen-zi" (覆盆子) is the fruit drug, used in Chinese traditional medicine as the remedies for impotence, pollution and premature ejaculation, bet-wetting, frequency of urination, etc. "Fu-pen-zi" from China Continent is considered to be derived from immature fruits of Rubus chingii Hu in general, while in local from other Rubus fruits. On the other hand, the botanical origin of "Fu-pen-zi" produced in Korea is regarded as R. coreanus MIQ., R. crataegifolius BUNGE, R. parvifolius L., etc. Rubu...

  12. Two new genera and three new species of Epipaschiinae Meyrick from China (Lepidoptera, Pyralidae

    Directory of Open Access Journals (Sweden)

    Mingqiang Wang

    2017-12-01

    Full Text Available Two new genera of Epipaschiinae are described. The genus Arcanusa Wang, Chen & Wu, gen. n. is established for Ar. apexiarcanusa Wang, Chen & Wu, sp. n. and Ar. sinuosa (Moore, 1888, comb. n., described in Scopocera Moore, 1888 (junior synonym of Stericta Lederer, 1863. The female genitalia of Ar. sinuosa (Moore, 1888, comb. n. are described for the first time. Androconia Wang, Chen & Wu, gen. n. is erected, including two new species, An. rallusa Wang, Chen & Wu, sp. n. and An. morulusa Wang, Chen & Wu, sp. n. Illustrations of all adults and their genitalia, and a key to the two new genera are provided.

  13. State of the Market

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Finance Financial performance remained sound and stable in July, although loans increased at a quick pace, said the People's Bank of China (PBC), the country's central bank. In July, money supply increased more rapidly (see graph 1). A total of 28.4 billion yuan of cash was put into circulation in this month, 3.8 billion yuan less than in the

  14. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 2037 ... Vol 14, No 11 (2015), Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii, Abstract PDF. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, Wei-wei Wang, Yuan-yuan Luo, Hou-zhao Wang.

  15. Construction of full-length cDNA library of white flower Salvia ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-05-18

    May 18, 2009 ... of S. miltiorrhiza bge (Yuan et al., 1990; Wang et al.,. 1998; Huang et al., 2000). Hairy roots and ... or A. tumefaciens strains (Chen et al., 1997; Song et al.,. 1997). ..... Chen H, Yuan JP, Chen F, Zhang YL, Song JY (1997).

  16. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Journals; Proceedings – Mathematical Sciences; Volume 118; Issue 4. An Optimal Version of an Inequality Involving the Third Symmetric Means. Wen Jiajin Yuan Jun Yuan Shufeng. Volume 118 Issue 4 November ... Keywords. Third symmetric mean of degree; optimal values; inequality; descending dimension method.

  17. Aerial Photography and Imagery, Ortho-Corrected - 2009 Digital Orthophotos - Miami-Dade County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB one-foot orthophotos to be mapped consists of 1,306 cells (approximately 1,174 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  18. Konteinernaja globlizatsija / Mihhail Tuzhikov

    Index Scriptorium Estoniae

    Tuzhikov, Mihhail

    2003-01-01

    Ülevaade Läänemere sadamate konteinervedudest - statistika, tendentsid. Tabelid: Kaubavahetus kontinentide järgi; Kaubavahetus Euroopa ja maailma sadamates; Konteinerveo käive sadamates. Kommenteerivad Sergei Artjomov, Aldis Zieds, Antonio Passaro, Vatslavas Grigalauskas, Stanislav Baiko

  19. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Manatee County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  20. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Manatee County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  1. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Hillsborough County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 1,384 cells (approximately 1,241 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  2. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Pinellas County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  3. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Charlotte County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  4. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Sarasota County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  5. Aerial Photography and Imagery, Ortho-Corrected - 2009 Digital Orthophotos - Monroe County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB, 8-bit, one-foot orthophotos to be mapped consists of 810 cells (approximately 727 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  6. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Hardee County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  7. [Mihai Eminescu luulefestivalil osales Jüri Talvet

    Index Scriptorium Estoniae

    2014-01-01

    Mihai Eminescu luulefestivalil esitleti mahukat tõlkeantoloogiat "Antologia poeziei universal de astăzi" (Craiova: Editura Europa”, 2014), mille on koostanud Ion Deaconescu. Antoloogias on ka Jüri Talveti luulet

  8. Aerial Photography and Imagery, Ortho-Corrected - 2008 Digital Orthophotos - Pinellas County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR half-foot orthophotos to be mapped consists of 2,258 cells (approximately 2,025 square miles) flown with a Z/I Intergraph DMC airborne digital sensor....

  9. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Hillsborough County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  10. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - Sarasota County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  11. Aerial Photography and Imagery, Ortho-Corrected - 2010 Digital Orthophotos - DeSoto County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The RGB/CIR ONE-foot orthophotos to be mapped consists of 4,362 cells (approximately 3,912 square miles) flown with a Z/I Intergraph DMC airborne digital sensor. The...

  12. Modeling and analysis of mobility management in mobile communication networks.

    Science.gov (United States)

    Baek, Woon Min; Yoon, Ji Hyun; Kim, Chesoong

    2014-01-01

    Many strategies have been proposed to reduce the mobility management cost in mobile communication networks. This paper studies the zone-based registration methods that have been adopted by most mobile communication networks. We focus on two special zone-based registration methods, called two-zone registration (2Z) and two-zone registration with implicit registration by outgoing calls (2Zi). We provide a new mathematical model to analyze the exact performance of 2Z and 2Zi. We also present various numerical results, to compare the performance of 2Zi with those of 2Z and one-zone registration (1Z), and show that 2Zi is superior to 2Z as well as 1Z in most cases.

  13. Clinical features of brain metastases in breast cancer: an implication for hippocampal-sparing whole-brain radiation therapy

    Directory of Open Access Journals (Sweden)

    Wu S

    2016-12-01

    Full Text Available San-Gang Wu,1,* Jia-Yuan Sun,2,* Qin Tong,3 Feng-Yan Li,2 Zhen-Yu He2 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 3Department of Radiation Oncology, The First Affiliated Hospital of University of South China, Hengyang, People’s Republic of China *These authors contributed equally to this work Objective: The objectives of this study were to describe the distribution of brain metastases (BM in breast cancer patients and investigate the risk factors for perihippocampal metastases (PHM. Patients and methods: Retrospective analysis of the clinicopathological characteristics and patterns of BM was performed. Associations between clinicopathological characteristics and PHM (the hippocampus plus 5 mm margin were evaluated using logistic regression analyses. Results: A total of 1,356 brain metastatic lesions were identified in 192 patients. Patients with 1–3 BM, 4–9 BM, and ≥10 BM accounted for 63.0%, 18.8%, and 18.2%, respectively. There were only 7 (3.6% patients with hippocampal metastases (HM and 14 (7.3% patients with PHM. On logistic regression, the number of BM was an independent risk factor for PHM. Patients with ≥10 BM had a significantly higher risk of PHM compared with those with <10 BM. Breast cancer subtype (BCS was not associated with PHM. The number of BM was significantly correlated with various BCSs. Patients with hormone receptor (HR+/human epidermal growth factor receptor 2 (HER2+, HR-/HER2+, and HR-/HER2- subtypes had a higher probability of ≥10 BM, relative to patients with an HR+/HER2- subtype. Conclusion: Our study suggests that a low incidence of PHM may be acceptable to perform hippocampal-sparing whole-brain radiation therapy for breast cancer patients

  14. Preoperative lymphocyte-to-monocyte ratio represents a superior predictor compared with neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios for colorectal liver-only metastases survival

    Directory of Open Access Journals (Sweden)

    Peng JH

    2017-07-01

    Full Text Available Jianhong Peng,1,* Hui Li,2,* Qingjian Ou,1,* Junzhong Lin,1 Xiaojun Wu,1 Zhenhai Lu,1 Yunfei Yuan,1 Desen Wan,1 Yujing Fang,1 Zhizhong Pan1 1Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Systemic inflammation was recognized as an essential factor contributing to the development of malignancies. This study aimed to investigate the prognostic value of preoperative lymphocyte-to-monocyte ratio (LMR, neutrophil-to-lymphocyte ratio (NLR, and platelet-to-lymphocyte ratio (PLR in patients with colorectal liver-only metastases (CLOM undergoing hepatectomy. We retrospectively enrolled 150 consecutive patients with CLOM between 2000 and 2012. The optimal cutoff values of continuous LMR, NLR, and PLR were determined using the receiver operating characteristic curve analysis. Recurrence-free survival (RFS and overall survival (OS related to the LMR, NLR, and PLR were analyzed using both Kaplan–Meier and multivariate Cox regression methods. Elevated LMR (≥2.82 and lower NLR (<4.63 were significantly associated with better RFS and OS in patients with CLOM after hepatectomy, instead of lower PLR (<150.17. Multivariate Cox analysis identified elevated LMR as the only independent inflammatory factor for better RFS (hazard ratio, 0.591; 95% CI, 0.32–0.844; P=0.008 and OS (hazard ratio, 0.426; 95% CI, 0.254–0.716; P=0.001. In the subgroup analysis, elevated LMR was a significant favorable factor in both 5-year RFS and OS of patients with male gender, lymph node metastases, colon cancer, liver tumor with the largest diameter <5 cm, preoperative carcinoembryonic antigen level <200 ng/mL, negative hepatitis B virus infection, non

  15. Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system

    Directory of Open Access Journals (Sweden)

    Duan S

    2012-07-01

    Full Text Available Shi-Yue Duan, Xue-Mei Ge, Nan Lu, Fei Wu, Weien Yuan, Tuo JinSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of ChinaAbstract: A chemically dynamic spermine-based polymer: polyspermine imidazole-4, 5-amide (PSIA, Mw > 7 kDa was designed, synthesized, and evaluated in terms of its ability to deliver nucleic acids. This polymer was made from an endogenous monomer professionally condensing genes in sperms, spermine, and a known safety drug metabolite, imidazole-4, 5-dicarboxylic acid, through a bis-amide bond conjugated with the imidazole ring. This polymer can condense pDNA at a W/W ratio above 10 to form polyplexes (100–200 nm in diameter, which is consistent with the observation by transmission electron microscopy (TEM, and the zeta potential was in the range of 10–20 mV. The pDNA packaged polymer was stable in phosphate buffer solution (PBS at pH 7.4 (simulated body fluid while the polyplexes were releasing pDNA into the solution at pH 5.8 (simulated endo-lysosomes due to the degradation of the bis-amide linkages in response to changes in pH values. PSIA-polyplexes were able to achieve efficient cellular uptake and luciferase gene silencing by co-transfection of pDNA and siRNA in COS-7 cells and HepG2 cells with negligible cytotoxicity. Biodistribution of Rhodamine B-labeled PSIA-polyplexes after being systemically injected in BALB/c nude-mice showed that the polyplexes circulated throughout the body, accumulated mainly in the kidney at 4 hours of sample administration, and moved to the liver and spleen after 24 hours. All the results suggested that PSIA offered a promising example to balance the transfection efficiency and toxicity of a synthetic carrier system for the delivery of therapeutic nucleic acids.Keywords: gene delivery, polyspermine, cytotoxicity, transfection efficiency, biodistribution

  16. Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Jian YS

    2017-03-01

    Full Text Available You-Sin Jian,1 Ching-Wen Chen,1 Chih-An Lin,2 Hsiu-Ping Yu,1 Hua-Yang Lin,3 Ming-Yuan Liao,1 Shu-Huan Wu,1 Yan-Fu Lin,1 Ping-Shan Lai1,2,4,5 1Department of Chemistry, 2PhD Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 3Preclinical Development Research Department, Holy Stone Healthcare Co., Ltd., Taipei, 4Research Center for Sustainable Energy and Nanotechnology, 5Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan Abstract: Carrier-mediated drug delivery systems are promising therapeutics for targeted delivery and improved efficacy and safety of potent cytotoxic drugs. Nimesulide is a multifactorial cyclooxygenase 2 nonsteroidal anti-inflammatory drug with analgesic, antipyretic and potent anticancer properties; however, the low solubility of nimesulide limits its applications. Drugs conjugated with hyaluronic acid (HA are innovative carrier-mediated drug delivery systems characterized by CD44-mediated endocytosis of HA and intracellular drug release. In this study, hydrophobic nimesulide was conjugated to HA of two different molecular weights (360 kDa as HA with high molecular weight [HAH] and 43kDa as HA with low molecular weight [HAL] to improve its tumor-targeting ability and hydrophilicity. Our results showed that hydrogenated nimesulide (N-[4-amino-2-phenoxyphenyl]methanesulfonamide was successfully conjugated with both HA types by carbodiimide coupling and the degree of substitution of nimesulide was 1%, which was characterized by 1H nuclear magnetic resonance 400 MHz and total correlation spectroscopy. Both Alexa Fluor® 647 labeled HAH and HAL could selectively accumulate in CD44-overexpressing HT-29 colorectal tumor area in vivo, as observed by in vivo imaging system. In the in vitro cytotoxic test, HA–nimesulide conjugate displayed >46% cell killing ability at a nimesulide concentration of 400 µM in HT-29 cells, whereas

  17. MicroRNA expression profiles in chronic epilepsy rats and neuroprotection from seizures by targeting miR-344a

    Directory of Open Access Journals (Sweden)

    Liu XX

    2017-07-01

    Full Text Available Xixia Liu,1,2 Yuhan Liao,1 Xiuxiu Wang,1 Donghua Zou,1 Chun Luo,1 Chongdong Jian,1 Yuan Wu1 1Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 2Department of Rehabilitation, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Abstract: MicroRNA (miRNA is believed to play a crucial role in the cause and treatment of epilepsy by controlling gene expression. However, it is still unclear how miRNA profiles change after multiple prolonged seizures and aggravation of brain injury in chronic epilepsy (CE. To investigate the role of miRNA in epilepsy, we utilized the CE rat models with pentylenetetrazol (PTZ and miRNA profiles in the hippocampus. miRNA profiles were characterized using miRNA microarray analysis and were compared with the rats in the sham group, which received 0.9% physiological saline treatment at the same dose. Four up-regulated miRNAs (miR-139–3p, -770–5p, -127–5p, -331–3p and 5 down-regulated miRNAs (miR-802–5p, -380–5p, -183–5p, -547–5p, -344a/-344a–5p were found in the CE rats (fold change >1.5, P<0.05. Three of the dysregulated miRNAs were validated by quantitative real-time polymerase chain reaction, which revealed an outcome consistent with the initial results of the miRNA microarray analyses. Then, miR-344a agomir was intracerebroventricularly injected and followed by PTZ induction of CE models to investigate the effect of miR-344a in chronic neocortical epileptogenesis. After miRNA-344a agomir and scramble treatment, results showed a restoration of seizure behavior and a reduction in neuron damage in the cortex in miRNA-334a agomir treated rats. These data suggest that miRNA-344a might have a small modulatory effect on seizure-induced apoptosis signaling pathways in the cortex. Keywords: microRNA, chronic epilepsy, miR-344a, epigenetics, apoptosis

  18. Stereotactic body radiation therapy for patients with recurrent pancreatic adenocarcinoma at the abdominal lymph nodes or postoperative stump including pancreatic stump and other stump

    Directory of Open Access Journals (Sweden)

    Zeng XL

    2016-06-01

    Full Text Available Xian-Liang Zeng,* Huan-Huan Wang,* Mao-Bin Meng, Zhi-Qiang Wu, Yong-Chun Song, Hong-Qing Zhuang, Dong Qian, Feng-Tong Li, Lu-Jun Zhao, Zhi-Yong Yuan, Ping Wang Department of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China *These authors contributed equally to this work Background and aim: The aim of this study is to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT using CyberKnife in the treatment of patients with recurrent pancreatic adenocarcinoma at the abdominal lymph node or stump after surgery. Patients and methods: Between October 1, 2006 and May 1, 2015, patients with recurrent pancreatic adenocarcinoma at the abdominal lymph node or stump after surgery were enrolled and treated with SBRT at our hospital. The primary end point was local control rate after SBRT. Secondary end points were overall survival, time to symptom alleviation, and toxicity, assessed using the Common Terminology Criteria for Adverse Events version 4.0. Results: Twenty-four patients with 24 lesions (17 abdominal lymph nodes and seven stumps were treated with SBRT, of which five patients presented with abdominal lymph nodes and synchronous metastases in the liver and lung. The 6-, 12-, and 24-month actuarial local control rates were 95.2%, 83.8%, and 62.1%, respectively. For the entire cohort, the median overall survival from diagnosis and SBRT was 28.9 and 12.2 months, respectively. Symptom alleviation was observed in eleven of 14 patients (78.6% within a median of 8 days (range, 1–14 days after SBRT. Nine patients (37.5% experienced Common Terminology Criteria for Adverse Events version 4.0 grade 1–2 acute toxicities; one patient experienced grade 3 acute toxicity due to thrombocytopenia. Conclusion: SBRT is a safe and

  19. The value of radiotherapy in breast cancer patients with isolated ipsilateral supraclavicular lymph node metastasis without distant metastases at diagnosis: a retrospective analysis of Chinese patients

    Directory of Open Access Journals (Sweden)

    Wu SG

    2014-02-01

    Full Text Available San-Gang Wu,1,* Jia-Yuan Sun,2,* Juan Zhou,3,* Feng-Yan Li,2 Qin Lin,1 Huan-Xin Lin,2 Zhen-Yu He2 1Xiamen Cancer Center, Department of Radiation Oncology, the First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China; 2Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China; 3Xiamen Cancer Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China *These authors contributed equally to this work Background: The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. Methods: We performed a retrospective analysis of clinical data for 39 patients with ISLM from breast cancer without distant metastasis at diagnosis. Combined modality therapy, consisting of neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy with or without adjuvant radiotherapy, was offered to the patients. Results: The patients in this study accounted for 1% of all breast cancer patients treated during the same time period. The median follow-up was 35 months. The 5-year locoregional recurrence-free survival, distant metastasis-free survival, disease-free survival (DFS, and overall survival (OS were 57.3%, 42.3%, 34.4%, and 46.2%, respectively. Twenty-three patients received postoperative adjuvant radiotherapy. However, there was no significant difference in the 3- and 5-year locoregional recurrence-free survival (P=0.693, ISLM-free recurrence (P=0.964, distant metastasis-free survival (P=0.964, DFS (P=0.234, and OS (P=0.329 rates between the groups of patients who received or did not receive adjuvant radiotherapy

  20. Postoperative radiotherapy for invasive micropapillary carcinoma of the breast: an analysis of Surveillance, Epidemiology, and End Results database

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    Wu SG

    2017-10-01

    Full Text Available San-Gang Wu,1,* Wen-Wen Zhang,2,* Jia-Yuan Sun,2 Feng-Yan Li,2 Yong-Xiong Chen,3 Zhen-Yu He2 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 3Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen, People’s Republic of China *These authors contributed equally to this work Introduction: Invasive micropapillary carcinoma (IMPC of the breast poses a high risk of locoregional recurrence, and postoperative radiotherapy (PORT may be beneficial in IMPC. Hence, we determined the clinical value of PORT in IMPC patients. Patients and methods: We assessed clinicopathological factors extracted from the Surveillance, Epidemiology, and End Results database (2004–2013. Univariate and multivariate Cox proportional hazards regressions were performed to assess the independent prognostic factors on breast cancer-specific survival (BCSS and overall survival (OS. Results: Of the 881 study patients, 444 (50.4% and 437 (49.6% underwent breast-conserving surgery (BCS and mastectomy (MAST, respectively, of whom 357 (80.4% and 153 (35.0% underwent PORT, respectively. Patients with young age, large tumor size, or advanced nodal stage were more likely to undergo MAST and PORT compared with MAST alone. Patients with progesterone receptor-positive disease were more likely to receive BCS and PORT compared with BCS alone. The 5-year BCSS and OS were 95.7% and 90.9%, respectively. On multivariate analyses, tumor size, histological grade, and estrogen receptor status were independent predictors of BCSS and OS. The types of surgical procedures (MAST vs. BCS were not an independent predictor of survival outcomes. Patients who

  1. Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway

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    Huang Y

    2018-02-01

    Full Text Available Yan Huang, Sun Wu, Yuan Zhang, Lihua Wang, Yan Guo Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China Introduction: T-cell lymphoblastic lymphoma (T-LBL is a widely disseminated disease worldwide. Triptolide (TPL is purified from Chinese herb and displays anti-inflammatory, anti-fertility, anti-tumor and immunosuppressive effects. Materials and methods: Here, in vitro and in vivo experiments were conducted to investigate the anti-tumor effect of TPL treatment in T-LBL and the potential mechanism in T-LBL progression. Results: TPL inhibited cell proliferation of T-LBL cells (Jurkat cells and Molt-3 cells in a dose-dependent manner. Flow cytometry analysis showed that cell apoptosis rate was increased by TPL treatment. TPL also up-regulated the expression of Caspase-3, Bax and down-regulated the expression of Bcl-2, indicating that TPL promoted apoptosis in Jurkat cells. Moreover, TPL inhibited invasion ability of Jurkat cells and down-regulated the expression of MMP-3 and MMP-9 in a dose-dependent manner. The expression of Snail, Slug, Twist and Integrin αVβ6 was decreased and the expression of E-cadherin was increased by TPL treatment, indicating that TPL inhibited EMT of Jurkat cells. Apart from that, TPL treatment attenuated the phoslevels of PI3K, Akt and mTOR and suppressed AKT activation compared with control group, suggesting that TPL inhibited PI3K/Akt/mTOR signal pathway in T-LBL. In vivo experiments showed that TPL inhibited tumor growth of T-LBL and promoted apoptosis of tumor cells. The expression of PCNA, Bcl-2, Snail, p-PI3K, p-Akt and mTOR was suppressed by TPL in a dose-dependent manner, suggesting that TPL suppressed tumor growth and promoted apoptosis of tumor cells by inhibiting PI3K/Akt/mTOR signal pathway in T-LBL. Conclusion: In conclusion, TPL exerted anti-tumor effect in T-LBL by inhibiting cell viability, invasion and EMT via regulating the PI3K

  2. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Science.gov (United States)

    Ahn, Sang-Hyeon

    2009-12-01

    We investigated the formation of Pochonka (Song of the Sky Pacers) and Chonmun yucho (Selected and classified writings on astrology) of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contents of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson's Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson's Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson's Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern) published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts that Choson

  3. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Directory of Open Access Journals (Sweden)

    Sang-Hyeon Ahn

    2009-12-01

    Full Text Available We investigated the formation of Pochonka (Song of the Sky Pacers and Chonmun yucho (Selected and classified writings on astrology of the early Choson dynasty. We recognized that the songs in these books were deeply influenced by those in a Chinese book Tong-zhi published in 1161 A.D., based on the following facts; the contnts of both treatises are described in the same order; the first phrase of the song for Thai-wei-yuan has composed of five words rather than seven words; in particular, Choson`s Pochonka has the song that describes the position of the Milky Way relative to asterisms, which was supplemented by the author Zheng Qiao. Since Tong-zhi were brought into Koryo in 1364 A.D., Choson`s Pochonka must be formed after that time. In particular, compared with Chinese Pu-tien-ko, Choson`s Pochonka stresses the colors of asterisms in order to represent the origin of each asterism with respect to the astronomers, Shih-shen, Kan-te, and Wu-Hsien. We also find that the star-charts in Pochonka and Chonsang-yolcha-punyajido (Chart of the asterisms and the regions they govern published in the early Choson dynasty are significantly similar in names, number of stars, and shapes of asterisms in them. This fact means that the star-charts in Pochonka originated from either the parent chart of Chonsang-yolcha-punyajido or Chonsang-yolcha-punyajido itself. The parent rubbing was reappeared in 1392 A.D. and carved on stele in 1396 A.D., and so the publication of Pochonka can be dated back to A.D. 1392. Chonmun yucho is a book that was formed by footnoting Pochonka with astrological descriptions in Chinese treatises. The formation period of Chonmun yucho is estimated to be 1440-1450 A.D. from the facts such as the biographical survey of the author Yi Sunji. Furthermore, Pochonka was adopted as a textbook of the government service examination for the astronomy division in Soungwan or the Royal Bureau of Astronomy in 1430 A.D.. We inferred from these facts

  4. Developing selective histone deacetylases (HDACs inhibitors through ebselen and analogs

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    Wang Y

    2017-05-01

    Full Text Available Yuren Wang,1 Jason Wallach,2 Stephanie Duane,1 Yuan Wang,1 Jianghong Wu,1 Jeffrey Wang,1 Adeboye Adejare,2 Haiching Ma1 1Reaction Biology Corp., Malvern, 2Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA Abstract: Histone deacetylases (HDACs are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other diseases. Different subtypes of HDACs appear to play disparate roles in the cells and are associated with specific diseases. Therefore, substantial effort has been made to develop subtype-selective HDAC inhibitors. In an effort to discover existing scaffolds with HDAC inhibitory activity, we screened a drug library approved by the US Food and Drug Administration and a National Institutes of Health Clinical Collection compound library in HDAC enzymatic assays. Ebselen, a clinical safe compound, was identified as a weak inhibitor of several HDACs, including HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 with half maximal inhibitory concentrations approximately single digit of µM. Two ebselen analogs, ebselen oxide and ebsulfur (a diselenide analog of ebselen, also inhibited these HDACs, however with improved potencies on HDAC8. Benzisothiazol, the core structure of ebsulfur, specifically inhibited HDAC6 at a single digit of µM but had no inhibition on other HDACs. Further efforts on structure–activity relationship based on the core structure of ebsulfur led to the discovery of a novel class of potent and selective HDAC6 inhibitors with RBC-2008 as the lead compound with single-digit nM potency. This class of histone deacetylase inhibitor features a novel pharmacophore with an ebsulfur scaffold selectively targeting HDAC6. Consistent with its inhibition on HDAC6, RBC-2008 significantly increased the acetylation levels of α-tubulin in PC-3 cells. Furthermore, treatment with these compounds led to

  5. Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells

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    Zhou Z

    2017-10-01

    Full Text Available Zhaoxiu Zhou,* Shuang Liu,* Yanfen Zhang, Xiantao Yang, Yuan Ma, Zhu Guan, Yun Wu, Lihe Zhang, Zhenjun Yang State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA. Single strands of siRNA targeting to BRAFV600E gene (siMB3 conjugated with cRGD peptide at 3'-terminus or 5'-terminus via cleavable disulfide bond was synthesized and then annealed with corresponding strands to obtain single and bis-cRGD-siRNA conjugates. A cationic lipid material (CLD developed by our laboratory was mixed with the conjugates to generate nanocomplexes; their uniformity and electrical property were revealed by particle size and zeta potential measurement. Compared with CLD/siBraf, CLD/cRGD-siBraf achieved higher cell uptake and more excellent tumor-targeting ability, especially 21 (sense-5′/antisense-3″-cRGD-congjugate nanocomplex. Moreover, they can regulate multiple pathways to varying degree and reduce acidification of endosome. Compared with the gene silencing of different conjugates, single or bis-cRGD-conjugated siRNA showed little differences except 22 (5/5 which cRGD was conjugated at 5'-terminus of antisense strand and sense strand. However bis-cRGD conjugate 21 nanocomplex exhibited better specific target gene silencing at multiple time points. Furthermore, the serum stabilities of the bis-cRGD conjugates were higher than those of the single-cRGD conjugates. In conclusion, all these data suggested that CLD/bis-conjugates, especially CLD/21, can be an effective system for delivery of siRNA to target BRAFV600E gene for therapy of melanoma. Keywords: cRGD-siRNA conjugates, cationic lipids, targeting, silencing, intracellular pathways

  6. Differences in esophageal cancer characteristics and survival between Chinese and Caucasian patients in the SEER database

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    Lin MQ

    2016-10-01

    Full Text Available Min-Qiang Lin,1,* Yue-Ping Li,2,* San-Gang Wu,3 Jia-Yuan Sun,4 Huan-Xin Lin,4 Shi-Yang Zhang,5 Zhen-Yu He4 1Department of Scientific Management, The First Affiliated Hospital of Xiamen University, Xiamen, 2Public Health School of Fujian Medical University, Fuzhou, 3Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, 4Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 5Department of Hospital Infection Management, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China *These authors contributed equally to this work Background: To compare the clinicopathologic characteristics and survival of Chinese and Caucasian esophageal cancer (EC patients residing in the US, using a population-based national registry (Surveillance Epidemiology and End Results [SEER] database. Methods: Patients with EC were identified from the SEER program from 1988 to 2012. Kaplan–Meier survival methods and Cox proportional hazards regression were performed.Results: A total of 479 Chinese and 35,748 Caucasian EC patients were identified. Compared with Caucasian patients, the Chinese patients had a later year of diagnosis, remained married after EC was diagnosed, had esophageal squamous cell carcinomas (ESCCs more frequently, had tumors located in the upper-third and middle-third of the esophagus more frequently, and fewer patients presented with poorly/undifferentiated EC and underwent cancer-directed surgery. In Chinese patients, the incidence of esophageal adenocarcinomas (EACs increased from 1988 to 2012 (P=0.054, and the majority of EAC patients had tumors located in the lower thoracic esophagus. The overall survival (OS was not significantly different between Chinese and Caucasian patients (P=0.767. However, Chinese patients with ESCC had a significantly better

  7. Power, identity and antiquarian approaches in modern Chinese art’

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    Chia-Ling Yang

    2014-06-01

    Full Text Available The pursuit of antiquity was important for scholarly artists in constructing their knowledge of history and cultural identity in late Imperial China. Following various publications by Bi Yuan 畢沅 (1730-1797, Wu Yi 武億 (1745-1799 and Qian Daxin 錢大昕 (1728-1804 in the 18th century, the study and collecting of rubbings of Northern Wei stone inscriptions and steles was popular. Such spread of interest in jinshi, inscriptions on metal and stone, also formed a base for studying seal carving, epigraphy and archaic painting. While traditional antiquarians would cherish inscriptions which enabled them to correct mistakes in the transmitted historical texts and the Classics, however, much of the antiquarian activity was adapted to mere literary exercise or connoisseurship, for instance, to supplying materials which could provide models for seal-carving and calligraphy. Examples could be seen in the calligraphy works and seal carvings of the Xiling bajia 西泠八家 (Eight Masters of Xiling, i.e. Hangzhou, also known as Zhe School of Calligraphy and Carving. Their keen interest in seeking inspiration from steles for their artistic presentations has been recorded in their writing and painting. In addition, the way the scholar-collector of the 19th and early 20th centuries mounted the rubbings, seals, inscriptions, paintings, letters and textual evidence studies into one album shows a changing ideology: rubbings were not only for scholarly study in classical learning, but were regarded as part of the art form and were appreciated on various social occasions. The antiquarian movement ultimately served as a tool for re-writing art historiography in modern China. This paper aims to address the phenomenon and formation of the jinshi painting that dominated in late Imperial and early modern China. Through case studies of three important jinshi societies in Shanghai, I will investigate in what way literary taste from the southern region gradually

  8. Peer review statement

    Science.gov (United States)

    2012-11-01

    All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the editors of the 26th IAHR Symposium on Hydraulic Machinery and Systems proceedings. Reviews were conducted by expert referees from the International Technical Committee to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. The members of the Scientific Committee who selected and reviewed the papers included in the Proceedings of the 26th IAHR Symposium on Hydraulic Machinery and Systems are: Yulin WU Tsinghua University China François AVELLAN EPFL-LMH Switzerland (principal) Xingqi LUO Xi'an University of Sci & Tech China Martin BÖHLE Kaiserslautern University Germany Gerard BOIS Arts et Métiers ParisTech France Luca D'AGOSTINO University of Pisa Italy Eduard EGUSQUIZA Polytechnical University Catalonia Spain Richard FISHER Voith Hydro Inc USA Regiane FORTES-PATELLA Institute Polytechnique de Grenoble France Aleksandar GAJIC University of Belgrade Serbia Wei YANG China Agriculture University China YinLu YOUNG University of Michigan USA Adrian LUNGU Dunarea de Jos University of Galati Romania Arpad FAY University of Miskolcz Hungary José GONZÁLEZ Universidad de Oviedo Spain Baoshan ZHU Tsinghua University China Hongxun CHEN Shanghai University China Chisachi KATO University of Tokyo Japan Zhenyue MA Dalian University of Sci & Tech China Honggang FAN Tsinghua University China François GUIBAULT Ecole Polytechnique de Montreal Canada Pengcheng GUO Xian University of Technology China Leqing WANG Zhejiang University China Toshiaki IKOHAGI Tohoku University Japan Jiandong YANG Wuhan University China Jianzhong ZHOU Huazhong University of Sci & Tech China Jinwei LI NULL China Rennian LI Lanzhou University of Sci & Tech China Houlin LIU NULL China Juan LIU Tsinghua University China Shuhong LIU Tsinghua University China Xianwu LUO Tsinghua University China Michihiro NISHI Tsinghua

  9. Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

    Directory of Open Access Journals (Sweden)

    Wang YY

    2015-12-01

    Full Text Available Yuanyuan Wang, Rong Wang, Yujie Wang, Ruqin Peng, Yan Wu, Yongfang Yuan Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Background: Liver fibrosis is the consequence of diverse liver injuries and can eventually develop into liver cirrhosis. Ginkgo biloba extract (GBE is an extract from dried ginkgo leaves that has many pharmacological effects because of its various ingredients and has been shown to be hepatoprotective. Purpose and methods: Aimed to investigate the underlying protective mechanisms of GBE on carbon tetrachloride (CCl4-induced liver fibrosis in rats. Male Sprague Dawley rats were randomly divided into four groups: control group (C, model group (M, low-dose group (L, and high-dose group (H. Liver fibrosis was induced by CCl4 groups M, L, and H: group C was administered saline. In addition, GBE at different doses was used to treat groups L and H. Results: The results of hematoxylin and eosin staining, Masson’s trichrome staining, a liver function index, and a liver fibrosis index showed that GBE application noticeably mitigated fibrosis and improved the function of the liver. The western blotting and immunohistochemistry analyses indicated that GBE reduced liver fibrosis not only by inhibiting p38 MAPK and NF-κBp65 via inhibition of IκBα degradation but also by inhibiting hepatocyte apoptosis via downregulation of Bax, upregulation of Bcl-2, and subsequent inhibition of caspase-3 activation. Inflammation-associated factors and hepatic stellate cell (HSC-activation markers further demonstrated that GBE could effectively inhibit HSC activation and inflammation as a result of its regulation of p38 MAPK and nuclear factor-kappa B/IκBα signaling. Conclusion: Our findings indicated a novel role for GBE in the treatment of liver fibrosis. The potential mechanisms may be associated with the following signaling pathways: 1 the p38 MAPK

  10. pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein

    Directory of Open Access Journals (Sweden)

    Xu D

    2013-09-01

    Full Text Available Dan Xu,1 Fei Wu,1 Yinghui Chen,2,* Liangming Wei,3,* Weien Yuan1,* 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, 3Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, People's Republic of China*These authors contributed equally to this workBackground: Encapsulating exogenous proteins into a nanosized particulate system for delivery into cells is a great challenge. To address this issue, we developed a novel nanoparticle delivery method that differs from the nanoparticles reported to date because its core was composed of cross-linked dextran glassy nanoparticles which had pH in endosome-responsive environment and the protein was loaded in the core of cross-linked dextran glassy nanoparticles.Methods: In this study, dextran in a poly(ethylene glycol aqueous two-phase system created a different chemical environment in which proteins were encapsulated very efficiently (84.3% and 89.6% for enhanced green fluorescent protein and bovine serum albumin, respectively by thermodynamically favored partition. The structures of the nanoparticles were confirmed by confocal laser scanning microscopy and scanning electron microscopy.Results: The nanoparticles had a normal size distribution and a mean diameter of 186 nm. MTT assays showed that the nanoparticles were nontoxic up to a concentration of 2000 µg/mL in human hepatocarcinoma cell line SMMC-7721, HeLa, and BRL-3A cells. Of note, confocal laser scanning microscopy studies showed that nanoparticles loaded with fluorescein isothiocyanate-bovine serum albumin were efficiently delivered and released proteins into the cytoplasm of HeLa cells. Flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that nanoparticles with a functional protein (apoptin efficiently induced

  11. Retrovõtmes pühamu / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2005-01-01

    Tallinnasse Lasnamäele plaanitava Jumalaema kiriku arhitektuurikonkursi võidutööst arhitektuuribüroolt Z-Projekt (arhitektid Oleg Zhemtshugov, Nikolai Djatko, Jevgeni Kolomenkin). Kommenteerib kunstiteadlane Mari-Liis Paaver. Ergutuspreemiad said arhitektuuribüroo ZiZi & YoYo projekt (arhitektid Veronika Valk, Yoko Alender) ning arhitektuuribüroo Lokomotiiv (arhitektid Jüri Martson, Rasmus Reinolt, Ivo-Martin Veelma)

  12. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Juturu V

    2016-10-01

    Full Text Available Vijaya Juturu,1 James P Bowman,2 Jayant Deshpande1 1Department of Scientific and Clinical Affairs, OmniActive Health Technologies Inc., Morristown, NJ, 2James P Bowman & Associates LLC, Loveland, OH, USA Purpose: Carotenoids, especially lutein and zeaxanthin isomers (L/Zi, filter blue light and protect skin from environmental factors including high-energy sources. These carotenoids may be able to block the formation of melanin pathways, decrease cytokines, and increase antioxidants.Subjects and methods: This is a randomized, double-blind, placebo-controlled clinical trial over a 12-week supplementation period. Fifty healthy people (50 healthy subjects were recruited and 46 subjects completed the study (males and females, age: 18–45 years with mild-to-moderate dry skin were included in this study. Skin type of the subjects was classified as Fitzpatrick skin type II–IV scale. Subjects were administered with either an oral dietary supplement containing 10 mg lutein (L and 2 mg zeaxanthin isomers (Zi (L/Zi: RR-zeaxanthin and RS (meso-zeaxanthin or a placebo daily for 12 weeks. The minimal erythemal dose and skin lightening (L* were measured via the Chromameter®. The individual typological angle was calculated. Subjective assessments were also recorded.Results: Overall skin tone was significantly improved in the L/Zi group compared to placebo (P<0.0237, and luminance (L* values were significantly increased in the L/Zi group. Mean minimal erythemal dose was increased with L/Zi supplementation after 12 weeks of supplementation. L/Zi supplementation significantly increased the individual typological angle.Conclusion: L/Zi supplementation lightens and improves skin conditions. Keywords: lutein, zeaxanthin isomers, skin lightening, minimal erythemal dose, individual typological angle, overall skin tone

  13. FOREWORD: 6th International Conference on Pumps and Fans with Compressors and Wind Turbines (ICPF2013)

    Science.gov (United States)

    Wu, Yulin; Wang, Zhengwei; Yuan, Shouqi; Shi, Weidong; Liu, Shuhong; Luo, Xingqi; Wang, Fujun

    2013-12-01

    ; other fluid machinery and devices, such as, wind turbines, turbochargers and reversible pump-turbines, clearance and sealing, jets, filters and mixers; and their engineering application and their system behavior, especially, the application of the renewable energy of pumps, compressors, fans and blowers. The objective of the conference was to provide an opportunity for researchers, engineers and students to report on the latest developments in the fields of pumps, compressors, fans and turbochargers, as well as systems. The participants were encouraged to present their work in progress with a short lead time, and the conference promoted discussion of the problems encountered. The ICPF2013 brought together 191 scientists and researchers from 14 countries, affiliated with universities, technology centers and industrial firms to debate topics related to advanced technologies for pumps and fans, which would enhance the sustainable development of fluid machinery and fluid engineering. The Scientific Committee selected 166 technical papers on the following topics: (i) Principles of Fluid Machinery, (ii) Pumps, (iii) Compressors, Fans and Turbochargers, (iv) Turbines, (v) Cavitation and Multiphase Flow, (vi) Systems and Other Fluid Machinery, and 10 invited plenary and invited session lectures, which were presented at the conference, to be included in the proceedings. All the papers of ICPF2013, which were published in this volume of IOP Conference Series: Materials Science and Engineering, have been peer reviewed through processes administered by the editors of the ICPF2013, those are Yulin Wu, Zhengwei Wang, Shouqi Yuan, Weidong Shi, Shuhong Liu, Xingqi Luo and Fujun Wang. We sincerely hope that the 6th International Conference on Pumps and Fans with Compressors and Wind Turbines is a significant step forward in the worldwide efforts to address the present challenges facing modern fluid machines. Professor Yulin Wu Chairman of the Local Organizing Committee 6th International

  14. FOREWORD: International Symposium of Cavitation and Multiphase Flow (ISCM 2014)

    Science.gov (United States)

    Wu, Yulin

    2015-01-01

    multiphase flow detection Fluid-structure interaction induced by cavitation and multiphase flow Multi-scale modelling of cavitating flows and Multiphase Flow Cavitation nuclei: theory and experiments Supercavitation and its applications Synergetic effects of cavitation and silt-laden erosion Shock waves and microjets generated by cavitation Nonlinear oscillations of gas and vapour bubbles Fundamentals of physics of acoustic cavitation Sonochemistry and sonoluminescence Biomedical applications of cavitation effects Ultrasonic cavitation for molten metal treatment Cavitation for enhanced heat transfer The ISCM 2014 brought together 95 scientists, researchers and graduate students from 11 countries, affiliated with universities, technology centers and industrial firms to debate topics related to advanced technologies for cavitation and Multiphase Flow, which would enhance the sustainable development of cavitation and Multiphase Flow in interdisciplinary sciences and technology. The technical committee selected 54 technical papers on the following topics: (i) Hydrodynamic Cavitation, (ii) Super Cavitation, (iii) Pump Cavitation, (iv) Acoustic Cavitation, (v) Interdisciplinary Research of Cavitation and Multi-Phase Flows, and 13 invited plenary and invited forum lectures, which were presented at the symposium, to be included in the proceedings. All the papers of ISCM 2014, which are published in this Volume of IOP Conference Series: Materials Science and Engineering, had been peer reviewed through processes administered by the editors of the ISCM 2014, those are Yulin WU, Shouqi YUAN, Zhengwei WANG, Shuhong LIU, Xingqi LUO, Fujun WANG and Guoyu WANG. The papers published in this Volume include 54 technical papers and 3 full length texts of the invited lectures. We sincerely hope that the International Symposium on Cavitation and Multiphase Flow is a significant step forward in the world wide efforts to address the present challenges in the modern science and technology. Professor

  15. Influence of mycorhization and soil organic matters on lead and antimony transfers to vegetables cultivated in urban gardens: environmental and sanitary consequences

    Science.gov (United States)

    Pierart, Antoine; Braud, Armelle; Lebeau, Thierry; Séjalon-Delmas, Nathalie; Dumat, Camille

    2014-05-01

    . References: Feng, R., Wei, C., Tu, S., Ding, Y., Wang, R., Guo, J., 2013. The uptake and detoxification of antimony by plants: a review. Environ. Exp. Bot. 96, 28-34. Foucault, Y., Lévêque, T., Xiong, T., Schreck, E., Austruy, A., Shahid, M., Dumat, C., 2013. Green manure plants for remediation of soils polluted by metals and metalloids: Ecotoxicity and human bioavailability assessment. Chemosphere 93, 1430-1435. Gu, H.H., Li, F.P., Yu, Q., Gao, Y.Q., Yuan, X.T., 2013. The Roles of Arbuscular Mycorrhizal Fungus Glomus mosseae and Festuca arundinacea in Phytostabilization of Lead/Zinc Tailings. Adv. Mater. Res. 699, 245-250. Lebeau, T., Braud, A., Jézéquel, K., 2008. Performance of bioaugmentation-assisted phytoextraction applied to metal contaminated soils: A review. Environ. Pollut. 153, 497-522. Sharma, A., Sharma, H., 2013. Role of Vesicular Arbuscular Mycorrhiza in the Mycoremediation of Heavy Toxic Metals From Soil. Int J LifeSc Bt Pharm Res 2, 2418-2431. Wu, F., Fu, Z., Liu, B., Mo, C., Chen, B., Corns, W., Liao, H., 2011. Health risk associated with dietary co-exposure to high levels of antimony and arsenic in the world's largest antimony mine area. Sci. Total Environ. 409, 3344-3351. Xiong, T., Austruy, A., Dappe, V., Leveque, T., Sobanska, S., Foucault, Y., Dumat, C., 2013. Phytotoxicity and bioaccessibility of metals for vegetables exposed to atmosphere fine particles in polluted urban areas". Urban Environmental Pollution, Asian Edition, 17-20, Beijing, China.

  16. International Symposium of Cavitation and Multiphase Flow (ISCM 2014)

    International Nuclear Information System (INIS)

    Wu, Yulin

    2015-01-01

    multiphase flow detection Fluid-structure interaction induced by cavitation and multiphase flow Multi-scale modelling of cavitating flows and Multiphase Flow Cavitation nuclei: theory and experiments Supercavitation and its applications Synergetic effects of cavitation and silt-laden erosion Shock waves and microjets generated by cavitation Nonlinear oscillations of gas and vapour bubbles Fundamentals of physics of acoustic cavitation Sonochemistry and sonoluminescence Biomedical applications of cavitation effects Ultrasonic cavitation for molten metal treatment Cavitation for enhanced heat transfer The ISCM 2014 brought together 95 scientists, researchers and graduate students from 11 countries, affiliated with universities, technology centers and industrial firms to debate topics related to advanced technologies for cavitation and Multiphase Flow, which would enhance the sustainable development of cavitation and Multiphase Flow in interdisciplinary sciences and technology. The technical committee selected 54 technical papers on the following topics: (i) Hydrodynamic Cavitation, (ii) Super Cavitation, (iii) Pump Cavitation, (iv) Acoustic Cavitation, (v) Interdisciplinary Research of Cavitation and Multi-Phase Flows, and 13 invited plenary and invited forum lectures, which were presented at the symposium, to be included in the proceedings. All the papers of ISCM 2014, which are published in this Volume of IOP Conference Series: Materials Science and Engineering, had been peer reviewed through processes administered by the editors of the ISCM 2014, those are Yulin WU, Shouqi YUAN, Zhengwei WANG, Shuhong LIU, Xingqi LUO, Fujun WANG and Guoyu WANG. The papers published in this Volume include 54 technical papers and 3 full length texts of the invited lectures. We sincerely hope that the International Symposium on Cavitation and Multiphase Flow is a significant step forward in the world wide efforts to address the present challenges in the modern science and technology. Professor

  17. Commentary on "Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer." Gray PJ, Paly JJ, Yeap BY, Sanda MG, Sandler HM, Michalski JM, Talcott JA, Coen JJ, Hamstra DA, Shipley WU, Hahn SM, Zietman AL, Bekelman JE, Efstathiou JA. Harvard Radiation Oncology Program, Boston, MA.: Cancer 2013;119(9):1729-35. doi: 10.1002/cncr.27956. [Epub 2013 Feb 22].

    Science.gov (United States)

    Gottschalk, Alexander

    2014-04-01

    Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam therapy (PBT). The authors reviewed patient-reported outcomes data collected prospectively using validated instruments that assessed bowel and urinary quality of life (QOL) for patients with localized prostate cancer who received 3DCRT (n = 123), IMRT (n = 153) or PBT (n = 95). Clinically meaningful differences in mean QOL scores were defined as those exceeding half the standard deviation of the baseline mean value. Changes from baseline were compared within groups at the first post-treatment follow-up (2-3 months from the start of treatment) and at 12 months and 24 months. At the first post-treatment follow-up, patients who received 3DCRT and IMRT, but not those who received PBT, reported a clinically meaningful decrement in bowel QOL. At 12 months and 24 months, all 3 cohorts reported clinically meaningful decrements in bowel QOL. Patients who received IMRT reported clinically meaningful decrements in the domains of urinary irritation/obstruction and incontinence at the first post-treatment follow-up. At 12 months, patients who received PBT, but not those who received IMRT or 3DCRT, reported a clinically meaningful decrement in the urinary irritation/obstruction domain. At 24 months, none of the 3 cohorts reported clinically meaningful changes in urinary QOL. Patients who received 3DCRT, IMRT, or PBT reported distinct patterns of treatment-related QOL. Although the timing of toxicity varied between the cohorts, patients reported similar modest QOL decrements in the bowel domain and minimal QOL decrements in the urinary domains at 24 months. Prospective randomized trials are needed to further examine these differences. © 2013 Published by Elsevier Inc.

  18. Analysis of Coastline Extraction from Landsat-8 OLI Imagery

    Directory of Open Access Journals (Sweden)

    Yaolin Liu

    2017-10-01

    Full Text Available Coastline extraction is a fundamental work for coastal resource management, coastal environmental protection and coastal sustainable development. Due to the free access and long-term record, Landsat series images have the potential to be used for coastline extraction. However, dynamic features of different types of coastlines (e.g., rocky, sandy, artificial, caused by sea level fluctuation from tidal, storm and reclamation, make it difficult to be accurately extracted with coarse spatial resolution, e.g., 30 m, of Landsat images. To access this problem, we analyze the performance of coastline extraction by integrating downscaling, pansharpening and water index approaches in increasing the accuracy of coastline extraction from the latest Landsat-8 Operational Land Imager (OLI imagery. In order to prove the availability of the proposed method, we designed three strategies: (1 Strategy 1 uses the traditional water index method to extract coastline directly from original 30 m Landsat-8 OLI multispectral (MS image; (2 Strategy 2 extracts coastlines from 15 m fused MS images generated by integrating 15 m panchromatic (PAN band and 30 m MS image with ten pansharpening algorithms; (3 Strategy 3 first downscales the PAN band to a finer spatial resolution (e.g., 7.5 m band, and then extracts coastlines from pansharpened MS images generated by integrating downscaled spatial resolution PAN band and 30 m MS image with ten pansharpening algorithms. Using the coastline extracted from ZiYuan-3 (ZY-3 5.8 m MS image as reference, accuracies of coastlines extracted from MS images in three strategies were validated visually and quantitatively. The results show that, compared with coastline extracted directly from 30 m Landsat-8 MS image (strategy 1, strategy 3 achieves the best accuracies with optimal mean net shoreline movement (MNSM of −2.54 m and optimal mean absolute difference (MAD of 11.26 m, followed by coastlines extracted in strategy 2 with optimal MNSM

  19. Photogrammetric Processing Using ZY-3 Satellite Imagery

    Science.gov (United States)

    Kornus, W.; Magariños, A.; Pla, M.; Soler, E.; Perez, F.

    2015-03-01

    This paper evaluates the stereoscopic capacities of the Chinese sensor ZiYuan-3 (ZY-3) for the generation of photogrammetric products. The satellite was launched on January 9, 2012 and carries three high-resolution panchromatic cameras viewing in forward (22º), nadir (0º) and backward direction (-22º) and an infrared multi-spectral scanner (IRMSS), which is slightly looking forward (6º). The ground sampling distance (GSD) is 2.1m for the nadir image, 3.5m for the two oblique stereo images and 5.8m for the multispectral image. The evaluated ZY-3 imagery consists of a full set of threefold-stereo and a multi-spectral image covering an area of ca. 50km x 50km north-west of Barcelona, Spain. The complete photogrammetric processing chain was executed including image orientation, the generation of a digital surface model (DSM), radiometric image correction, pansharpening, orthoimage generation and digital stereo plotting. All 4 images are oriented by estimating affine transformation parameters between observed and nominal RPC (rational polynomial coefficients) image positions of 17 ground control points (GCP) and a subsequent calculation of refined RPC. From 10 independent check points RMS errors of 2.2m, 2.0m and 2.7m in X, Y and H are obtained. Subsequently, a DSM of 5m grid spacing is generated fully automatically. A comparison with the Lidar data results in an overall DSM accuracy of approximately 3m. In moderate and flat terrain higher accuracies in the order of 2.5m and better are achieved. In a next step orthoimages from the high resolution nadir image and the multispectral image are generated using the refined RPC geometry and the DSM. After radiometric corrections a fused high resolution colour orthoimage with 2.1m pixel size is created using an adaptive HSL method. The pansharpen process is performed after the individual geocorrection due to the different viewing angles between the two images. In a detailed analysis of the colour orthoimage artifacts are

  20. People’s Republic of China Scientific Abstracts No. 178

    Science.gov (United States)

    1977-10-27

    of hepatic colls were observed by eleotron microscopy after carbon tetrachloride intoxication in mice . The hepatic cellular injuries were protected...administration in [continuation of SHENG-WU HUA-HSUEH YU SHENG-WU WU-LI-HSUEH-PAO Vol 8, No A, Dec 76 pp 333-340] mice . It is transformed from lipid...preparations for monopolizing the technique by capi- talist and revisionist countries. In a socialist country, the author claims, the purpose of developing

  1. Effects of three warm-up regimens of equal distance on VO2 kinetics during supramaximal exercise in Thoroughbred horses.

    Science.gov (United States)

    Mukai, K; Hiraga, A; Takahashi, T; Ohmura, H; Jones, J H

    2010-11-01

    Several studies have indicated that even low-intensity warm-up increases O(2) transport kinetics and that high-intensity warm-up may not be needed in horses. However, conventional warm-up exercise for Thoroughbred races is more intense than those utilised in previous studies of equine warm-up responses. To test the hypothesis that warm-up exercise at different intensities alters the kinetics and total contribution of aerobic power to total metabolic power in subsequent supramaximal (sprint) exercise in Thoroughbred horses. Nine well-trained Thoroughbreds ran until fatigue at 115% of maximal oxygen consumption (VO2max) 10 min after warming-up under each of 3 protocols of equal running distance: 400 s at 30% VO2max (LoWU), 200 s at 60% VO2max (MoWU) and 120 s at 100% VO2max (HiWU). Variables measured during exercise were rates of O(2) and CO(2) consumption/production (VO2,VO2), respiratory exchange ratio (RER), heart rate, blood lactate concentration and accumulation rate and blood gas variables. VO2 was significantly higher in HiWU than in LoWU at the onset of the sprint exercise and HR was significantly higher in HiWU than in LoWU throughout the sprint. Accumulation of blood lactate, RER, P(a)CO(2) and PvCO2 in the first 60 s were significantly lower in HiWU than in LoWU and MoWU. There were no significant differences in stroke volume, run time or arterial-mixed venous O(2) concentration. These results suggest HiWU accelerates kinetics and reduces reliance on net anaerobic power compared with LoWU at the onset of the subsequent sprint. © 2010 EVJ Ltd.

  2. Assessment of private economic benefits and positive environmental externalities of tea plantation in China.

    Science.gov (United States)

    Xue, Hui; Ren, Xiaoyi; Li, Shiyu; Wu, Xu; Cheng, Hao; Xu, Bin; Gu, Baojing; Yang, Guofu; Peng, Changhui; Ge, Ying; Chang, Jie

    2013-10-01

    Tea plantations are rapidly expanding in China and other countries in the tropical and subtropical zones, driven by relatively high private economic benefit. However, the impact of tea plantations on the regional environment, including ecosystem services and disservices are unclear. In this study, we developed an assessment framework for determining the private economic benefits and environmental externalities (the algebraic sum of the regulating services and disservices) of tea plantations in China. Our results showed that tea plantations provided private economic benefits of 5,652 yuan ha(-1) year(-1) (7.6 yuan = 1 USD in 2007) for tea farmers, plus positive environmental externalities of 6,054 yuan ha(-1) year(-1) for the society. The environmental externalities were calculated as the sum of the value of four regulating services, including carbon sequestration (392 yuan ha(-1) year(-1)); soil retention (72 yuan ha(-1) year(-1)); soil fertility protection (3,189 yuan ha(-1) year(-1)) and water conservation (2,685 yuan ha(-1) year(-1)), and three disservices, including CO2 emission (-39 yuan ha(-1) year(-1)), N2O emission (-137 yuan ha(-1) year(-1)) and nonpoint source pollution (-108 yuan ha(-1) year(-1)). Before the private optimal level, the positive environmental externalities can be maintained by private economic benefits; if a social optimal level is required, subsidies from government are necessary.

  3. [A cost-benefit analysis of occupational disease reporting in China].

    Science.gov (United States)

    Tang, X Z; Zeng, Q; Liu, D S

    2017-03-20

    Objective: To perform a cost-benefit analysis of the occupational disease reporting system in China, and to provide a basis for effective resource allocation. Methods: The data on the cost of occupational diseases were collected from China Health Statistics Yearbook 2013, the estimated benefit data were collected from published articles in China and foreign countries, and the probability data were collected from the occupational diseasereports published by health and family planning administrative departments. Adecision-making tree was used for the cost-benefit analysis. Results: The estimated cost of occupational disease reporting was about 102.47 million yuan/year, consisting of a cost of reporting in national medical institutions of 1.25 million yuan/year, a management cost of 30.35 million yuan/year, a management cost in local public health institutions of 69.80 million yuan/year, a management cost in national public health institutions of 370 thousand yuan/year, and a cost of construction and maintenance of reporting system of 700 thousand yuan/year. The results of the decision tree analysis showed that when an occupational disease monitoring system was established, the incremental input for occupational disease monitoring and prevention/control was 2.1 billion yuan/year, the output was 6.5 billion yuan/year, and the benefit of occupational disease reporting system was 4.4 billion yuan/year. Conclusion: The benefit of occupational disease reporting system depends on the cost-benefit of occupational disease prevention and control measures, and proper prevention and control measures are extremely important for improving the benefit of occupational disease reporting system.

  4. Evaluation of nano-technology-modified zirconia oral implants: a study in rabbits.

    Science.gov (United States)

    Lee, Jaebum; Sieweke, Janet H; Rodriguez, Nancy A; Schüpbach, Peter; Lindström, Håkan; Susin, Cristiano; Wikesjö, Ulf M E

    2009-07-01

    The objective of this study was to screen candidate nano-technology-modified, micro-structured zirconia implant surfaces relative to local bone formation and osseointegration. Proprietary nano-technology surface-modified (calcium phosphate: CaP) micro-structured zirconia implants (A and C), control micro-structured zirconia implants (ZiUnite), and titanium porous oxide implants (TiUnite) were implanted into the femoral condyle in 40 adult male New Zealand White rabbits. Each animal received one implant in each hind leg; thus, 20 animals received A and C implants and 20 animals received ZiUnite and TiUnite implants in contralateral hind legs. Ten animals/group were euthanized at weeks 3 and 6 when biopsies of the implant sites were processed for histometric analysis using digital photomicrographs produced using backscatter scanning electron microscopy. The TiUnite surface demonstrated significantly greater bone-implant contact (BIC) (77.6+/-2.6%) compared with the A (64.6+/-3.6%) and C (62.2+/-3.1%) surfaces at 3 weeks (p0.05). Similarly, there were non-significant differences between the TiUnite and the ZiUnite surfaces (p>0.05). At 6 weeks, there were no significant differences in BIC between the TiUnite (67.1+/-4.2%), ZiUnite (69.7+/-5.7%), A (68.6+/-1.9%), and C (64.5+/-4.1%) surfaces (p>0.05). TiUnite and ZiUnite implant surfaces exhibit high levels of osseointegration that, in this model, confirm their advanced osteoconductive properties. Addition of CaP nano-technology to the ZiUnite surface does not enhance the already advanced osteoconductivity displayed by the TiUnite and ZiUnite implant surfaces.

  5. Advanced Materials and Processing 2010

    Science.gov (United States)

    Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

    2011-06-01

    Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

  6. China’s Foreign Trade: The Response to Changing the Exchange Rate

    Directory of Open Access Journals (Sweden)

    Izotov D. A.

    2011-12-01

    Full Text Available Based on official data of Chinese and international statistics assessment is given of the impact of the yuan revaluation on the parameters of China’s foreign trade by country (including in terms of crisis tendencies in the global economy. A regression analysis made it possible to obtain quantitative assessments of the responses of China’s foreign trade parameters by country, depending on different yuan revaluation (10% and 50% to the U.S. dollar. It is found that the yuan revaluation leads to reduction in the growth rates of both China’s exports and imports, with the responses by countries being different

  7. The long-term use of zygomatic implants: a 10-year clinical and radiographic report.

    Science.gov (United States)

    Aparicio, Carlos; Manresa, Carolina; Francisco, Karen; Ouazzani, Wafaa; Claros, Pedro; Potau, Josep M; Aparicio, Arnau

    2014-06-01

    The zygoma implant has been an effective option in the short-term management of the atrophic edentulous maxilla. To report on long-term outcomes in the rehabilitation of the atrophic maxilla using zygomatic (ZI) and regular implants (RI). 22 consecutive zygomatic patients in a maintenance program were included. Cumulative survival rate (CSR) of ZI, RI, prostheses, and complications were recorded during, at least, 10 years of loading. Implant mobility was tested using Periotest(®). Sinus health was radiographically and clinically assessed according to Lund-Mackay (L-M) score and Lanza and Kennedy survey, respectively. A satisfaction questionnaire and anatomical measurements were also performed. Patients received 22 prostheses, anchored on 172 implants. Forty-one were ZI. Three RI failed (10 years CSR = 97.71%). Two ZI were partly removed due to perimplant infection (10 years CSR = 95.12%). All patients maintained functional prostheses. One patient fractured framework twice. Loosening or fracturing screws happened in 11 patients. Seven patients fractured occlusal material. Four ZI abutments in two patients were disconnected because of uncomfortable prostheses. Alveolar height at the ZI head level on the right and left sides was 2.64 mm and 2.25 mm, respectively. Mean distance of ZI head center to ridge center, on the right and left sides was 4.54 mm and 5.67 mm, respectively. Mean Periotest values (PTv) of ZI were -4.375 PTv and -4.941 PTv before prostheses placement and after 10 years, respectively. Six patients experienced sinusitis 14-127 months postoperatively. 54.55% of the L-M scores did not present opacification (L-M = 0) in any sinus. Osteomeatal obstruction happened in eight patients (two bilateral). Two (9.09%) were diagnosed with sinusitis. Eighty-four percent reported satisfaction levels above 80%. 31.81% reported maximum satisfaction score (100%). The long-term rehabilitation of the severely atrophic maxillae using ZI is a predictable procedure. © 2012

  8. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Voice Intensity

    Directory of Open Access Journals (Sweden)

    Sofie Lundgren

    2011-01-01

    Full Text Available Deep brain stimulation of the subthalamic nucleus (STN-DBS in patients with Parkinson's disease (PD affects speech inconsistently. Recently, stimulation of the caudal zona incerta (cZi-DBS has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated. The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients. Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group, before- and 12 months after-surgery on- and off-stimulation. For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0 dB contra 72.1 (2.2 dB (=.002 for STN-DBS, and 71.6 (4.1 dB contra 72.8 (3.4 dB (=.03 for cZi-DBS, with significant interaction (<.001. Intensity decay showed no significant changes. The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.

  9. Extending the Applicability of the Generalized Likelihood Function for Zero-Inflated Data Series

    Science.gov (United States)

    Oliveira, Debora Y.; Chaffe, Pedro L. B.; Sá, João. H. M.

    2018-03-01

    Proper uncertainty estimation for data series with a high proportion of zero and near zero observations has been a challenge in hydrologic studies. This technical note proposes a modification to the Generalized Likelihood function that accounts for zero inflation of the error distribution (ZI-GL). We compare the performance of the proposed ZI-GL with the original Generalized Likelihood function using the entire data series (GL) and by simply suppressing zero observations (GLy>0). These approaches were applied to two interception modeling examples characterized by data series with a significant number of zeros. The ZI-GL produced better uncertainty ranges than the GL as measured by the precision, reliability and volumetric bias metrics. The comparison between ZI-GL and GLy>0 highlights the need for further improvement in the treatment of residuals from near zero simulations when a linear heteroscedastic error model is considered. Aside from the interception modeling examples illustrated herein, the proposed ZI-GL may be useful for other hydrologic studies, such as for the modeling of the runoff generation in hillslopes and ephemeral catchments.

  10. Scientists warn of increasing corruption despite 18% cash hike

    Science.gov (United States)

    Li, Jiao

    2013-04-01

    China has spent more than 1400bn (8729 billion yuan) on R&D over the past five years representing an average annual increase of over 18%, according to data from the country's National Bureau of Statistics.

  11. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. OuYang Yuhua1 2 Yuan Ping1. College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730 070, China. School of Mathematics, Physics and Software Engineering, Lanzhou Jiaotong University, Lanzhou 730 070, China.

  12. DNA binding and cleavage activity of a structurally characterized Ni(II)

    Indian Academy of Sciences (India)

    bChemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India. cDepartment of Chemistry, Chung Yuan Christian University, Chung Li, Taiwan 32023, ROC ..... Financial support by the Department of Science &.

  13. Soumitro Banerjee Department of Electrical Engineering Indian ...

    Indian Academy of Sciences (India)

    THEORY AND OPEN PROBLEMS. Soumitro Banerjee ... Any system whose status changes with time. • Dynamical systems .... Walking robots. • Hydraulic systems .... And to apply it in various fields of science and engineering. 1. Guohui Yuan ...

  14. Comment on: Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-analysis of prospective Studies, Nutrients 2017, 9, 688

    Directory of Open Access Journals (Sweden)

    Gilberto F. Hurtado-Torres

    2017-08-01

    Full Text Available Shen Yuan et al. [1] highlight the protective cardiometabolic effects of chocolate intake. Without doubt, their work contributes to support evidence about the salutary and wide protective effects of chocolate compounds, particularly flavanols and its derivatives.[...

  15. Disease: H01879 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01879 Wiedemann-Steiner syndrome; Alazami-Yuan syndrome Wiedemann-Steiner Syndrom...a N, Matsumoto N ... TITLE ... Delineation of clinical features in Wiedemann-Steiner syndrome caused by KMT2A

  16. African Journal of Biotechnology - Vol 11, No 69 (2012)

    African Journals Online (AJOL)

    In silico comparative analysis of EST-SSRs in three cotton genomes · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Daojun Yuan, Shaoguang Liang, Zhongxu Lin, Xianlong Zhang, 13269-13371 ...

  17. When the Night Falls

    Institute of Scientific and Technical Information of China (English)

    JOHN; BUTCHER

    2008-01-01

    Evenings in Beijing today are more about beer and dancing than tea and taiji Dug out in the Yuan Dynasty(1279-1368), Houhai Lake onceserved as berth for barges from theGrand Canal, bringing goods from

  18. Learning Han Cultures on Horseback

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The "Think Tank in the Plain of Golden Lotuses" played important roles in the founding of the Yuan Dynasty.It came into being because of the enthusiasm of Kublai towards Han cultures and his political ambitions.

  19. [Dynamic changes of Ruoergai Plateau wetland ecosystem service value].

    Science.gov (United States)

    Zhang, Xiao-Yun; Lü, Xian-Guo; Shen, Song-Ping

    2009-05-01

    Based on the satellite remote sensing data acquired in 1975 and 2006, and by using the assessment method of ecosystem service value, the dynamic changes of physical production value, gas regulation value, and water storage value of Ruoergai Plateau wetland ecosystem in 1975-2006 were studied. During study period, the total value of the three services decreased from 19.59 billion RMB Yuan to 12.38 billion Yuan RMB, among which, physical production value increased by 0.302 billion RMB Yuan, while the gas regulation and water storage value decreased by 7.507 billion RMB Yuan. The benefit from the increase of physical production was much less than the loss of ecosystem degradation. Overgrazing induced the biomass reduction and soil deterioration, resulting in the decline of Ruoergai Plateau wetland ecosystem service value and service capacity.

  20. Facile template-free hydrothermal synthesis and microstrain ...

    Indian Academy of Sciences (India)

    Administrator

    2009), solar cells (Yuan et al 2011), transparent elec- trodes (Kim et al ... increasing the peak width, intensity and shifting the 2θ peak position. ... Facile template-free hydrothermal synthesis and microstrain measurement of ZnO nanorods. 399.

  1. State of the Market

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Finance Financial performance remained sound and stable in the first half of this year, though deposits and loans increased at a quick pace, said the People's Bank of China (PBC), the country's central bank. During the January-June period, the increase of money supply began to slow (see graph 1). A total of 56.3 billion yuan of Graph 1: Money Supply, Jan-June trillion yuan % 40

  2. Are You Creditworthy?

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A central bank personal credit information database is set to help banks make informed decisions when approving credit cards or loans Deng Ming, a fresh graduate who works with a newspaper in Beijing, spends almost all her monthly salary. But she has 12 credit cards with credit lines ranging from 3,000 to 8,000 yuan, with the total credit line touching 60,000 yuan. Deng said she

  3. JPRS Report China.

    Science.gov (United States)

    1988-06-20

    191,800, up 1.5 percent from 1986. The total included 78,400 doctors, 38,900 nurses , and 74,500 other health workers. Progress was made in disease...eliminated rinderpest; essentially brought pleurop- neumonia, brucellosis, foot-and-mouth disease, anthrax, equine infectious anemia, swine erysipelas...investments of 4.5 billion yuan to build livestock commodity bases during the Seventh 5-Year Plan and 1 billion yuan for grassland construction, veterinary

  4. INTERNET ADVERTISING AT A GLANCE

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Shanghai-based Internet analysis and consulting company iResearch released its China Advertising Online Research Report 2005 in March. The report indicates that the market value of online advertising in China reached 3.13 billion yuan in 2005, up 77.1 percent over the previous year. The market observer predicts a 48 percent growth to 4.6 billion yuan for 2006.

  5. Glaring IPO

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China Everbright Bank dazzles the domestic stock market with China’s second largest IPO this year As it launched its initial public offering(IPO) in Shanghai on August 18, 2010,China Everbright Bank Co. Ltd. was greeted with a warm welcome- shares of the mid-sized bank closed at 3.66 yuan($0.54) on its first trading date, jumping 18 percent from the IPO price of 3.1 yuan($0.46).

  6. State of the Market

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Industrial Profits In the first two months, the combined profits of all state-owned enterprises as well as non-state enterprises with annual sales revenue of more than 5 million yuan (enterprises above designated size) totaled 203.4 billion yuan, increasing 21.8 percent compared with the same period last year, according to the National Bureau of Statistics (NBS) (see graph 1).

  7. State of the Market

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Industrial Profits From January to June, the total volume of profits made by all state-owned enterprises as well as non-state enterprises with annual sales revenue of more than 5 million yuan (enterprises above designated size) stood at 810.7 billion yuan, expanding 28 percent compared with the same period last year, according to the National Bureau of Statistics (NBS) (see graph 1).

  8. China’s Currency: Economic Issues and Options for U.S. Trade Policy

    Science.gov (United States)

    2008-05-22

    otherwise, the results may represent nothing more than spurious correlation. One rationale is called the “ Balassa - Samuelson ” effect: as countries get richer...the mobility of labor and capital in China may interfere with the Balassa - Samuelson effect.45 Cheung et al. are able to replicate others’ results...overall U.S. trade deficit is unsustainable, and revaluing the yuan would reduce it. This goes beyond an argument that China has fixed the yuan at an

  9. MARKET WATCH

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    By expanding yuan settlement in cross-border trade andallowing cross-border direct investment in the yuan, China aims to pushforward the internationalization of its currency. House prices are still holding up inChina, but property developers are under increasing pressures. China’s goldmarket bursts with vitality as investors seek safety amid soaringinflation. The automaker BYD faces serious headwinds due to a plunge insales. The telecom giant China Mobile faces slower growth in its customerbase due to cutthroat market competition.

  10. China Report, Economic Affairs, No. 381

    Science.gov (United States)

    1983-09-13

    taxes must be levied on the purchase and sales of livestock. Livestock butchery taxes must be imposed on livestock butchers . The regulations also...20 yuan is taxable and any sales below 20 yuan is exempt from taxation. Fire- wood, grass, poultry , eggs, vegetables, melons, fruits, and potatoes...aquatic products, poultry , fresh eggs, beef cattle, mutton sheep, frontier marketed tea, vegetables, cotton, cotton for wadding, silkworm cocoons

  11. Biisofraxidin on Apoptosis of Human Gastric Cancer BGC-823 Cells

    African Journals Online (AJOL)

    Wu et al. Trop J Pharm Res, October 2015; 14(10): 1803. Tropical Journal of Pharmaceutical Research ... Jian-Tao Wu1,2*, She-Min Lv1, Chun-Hui Lu1, Jun Gong1 and Jian-Bo An3 ..... Zhu AK, Zhou H, Xia JZ, Jin HC, Wang K, Yan J, Zuo JB,.

  12. Developing institutional collaboration between Wageningen university and the Chinese academy of agricultural sciences

    NARCIS (Netherlands)

    Bonnema, A.B.; Lin, Z.; Qu, L.; Jacobsen, E.

    2006-01-01

    Scientific co-operation between the Chinese Academy of Agricultural Sciences (CAAS) and Wageningen University (WU) has been underway since 1990, especially in the field of plant sciences. In 2001, CAAS and WU initiated a formal joint PhD training programme to further structure their co-operation.

  13. African Journal of Biotechnology - Vol 9, No 15 (2010)

    African Journals Online (AJOL)

    cDNA, genomic sequence cloning and overexpression of ribosomal protein S16 gene (RPS16) from the Giant Panda · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. W Hou, Y Hou, Y Hao, T Zhang, Z Peng, Y Wu, G Wu, 2185-2191 ...

  14. Synthesis of agarose–metal/semiconductor nanoparticles having ...

    Indian Academy of Sciences (India)

    Wintec

    Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur PO, Bangalore 560 064 b. Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific ..... Li P, Li J, Wu C, Wu Q and Li J 2005 Nanotechno- logy. 16 1912. 18. Gadi B and Jeffrey G 2005 Curr. Med. Chem. 12 2163. 19. Gadi B and ...

  15. ACUTE EFFECTS OF STATIC STRETCHING, DYNAMIC EXERCISES, AND HIGH VOLUME UPPER EXTREMITY PLYOMETRIC ACTIVITY ON TENNIS SERVE PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Ertugrul Gelen

    2012-12-01

    Full Text Available The purpose of this study was to compare the acute effects of static stretching; dynamic exercises and high volume upper extremity plyometric activity on tennis serve performance. Twenty-six elite young tennis players (15.1 ± 4.2 years, 167.9 ± 5.8 cm and 61.6 ± 8.1 kg performed 4 different warm-up (WU routines in a random order on non-consecutive days. The WU methods consisted of traditional WU (jogging, rally and serve practice (TRAD; traditional WU and static stretching (TRSS; traditional WU and dynamic exercise (TRDE; and traditional WU and high volume upper extremity plyometric activity (TRPLYP. Following each WU session, subjects were tested on a tennis serve ball speed test. TRAD, TRSS, TRDE and TRPLYO were compared by repeated measurement analyses of variance and post-hoc comparisons. In this study a 1 to 3 percent increase in tennis serve ball speed was recorded in TRDE and TRPLYO when compared to TRAD (p 0.05. ICCs for ball speed showed strong reliability (0.82 to 0.93 for the ball speed measurements.The results of this study indicate that dynamic and high volume upper extremity plyometric WU activities are likely beneficial to serve speed of elite junior tennis players.

  16. Women in physics

    CERN Document Server

    Indovino, Shaina

    2013-01-01

    What does it take to be a physicist? Lise Meitner, Katharine Blodgett, Maria Goeppert-Mayer, Chien-Shiung Wu, Ursula Franklin, Argelia Velez-Rodriguez, Sau Lan Wu, Shirley Ann Jackson, Lisa Randall and opportunities for women in physics today.

  17. DMPD: Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15331118 Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. Wu...e-associated up-regulation in macrophage PGE2 synthesis. PubmedID 15331118 Title Mechanism of age-associated... up-regulation in macrophage PGE2 synthesis. Authors Wu D, Meydani SN. Publicatio

  18. Spectrum-effect relationships between high performance liquid ...

    African Journals Online (AJOL)

    promoting effect on contractility of intestinal smooth was carried out to ... addition, the equation of spectrum-effect relationships {Y = 3.818 - 1.126X1 + ..... Peng W, Liu YJ, Wu N, Sun T, He XY, Gao YX, Wu CJ. ... Zheng QF, Zhao YL, Wang JB, Liu TT, Zhang B, Gong ... Zhao HY, Han X. Research thoughts and application.

  19. Download this PDF file

    African Journals Online (AJOL)

    pc

    2017-11-10

    Nov 10, 2017 ... ts of alkyl chain length on particles morphology were primarily studied ..... [3] Li Z, Yu L, Zheng L, Li N, Han S, Li G. Characterization studies on the ionic ... [4] Chiang YD, Lian HY, Leo SY, Wang SG, Yamauchi Y, Wu KC. ... [20] Yu YJ, Xing JL, Pang JL, Jiang SH, Lam KF, Yang TQ, Xue QS, Zhang K, Wu P.

  20. Fundamental Investigations into the Infrared Properties of Carbon Nanotubes

    Science.gov (United States)

    2013-01-23

    Vallejo , Rongtao Lu, Judy Wu. Development of Textured Magnesium Oxide Templates on Amorphous Polymer SurfacesUsing Ion-Beam-Assisted Deposition, Applied...Applied Physics Letters 99, 023111 (2011) 18. A. Elliot, Vallejo , R.T. Lu, and J.Z. Wu, “Development of Textured Magnesium Oxides Templates on

  1. Vegetation Impact on Soil Strength: A State of the Knowledge Review

    Science.gov (United States)

    2017-06-20

    CRREL SR-17-2 3 soil layers. However, their more thorough look at the Wu (1976) and Wal- dron (1977) root–soil model for soil cohesion indicated a...trafficability and mobility simulations (Wu 1976; Waldron 1977; Wal- dron and Dakessian 1981 as cited in Pirnazarov and Sellgren 2015). Figure 6. Maximum

  2. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Anhua Wu. Articles written in Bulletin of Materials Science. Volume 27 Issue 4 August 2004 pp 333-336 Crystal Growth. Bridgman growth and defects of Nd : Sr3Ga2Ge4O14 laser crystals · Jiaxuan Ding Anhua Wu Jiayue Xu · More Details Abstract Fulltext PDF.

  3. Steam supply and power cogeneration at Yanshan Petrochemical Co., Ltd.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the purpose of reducing greenhouse effect gas emissions, a project was studied for the improvement of cogeneration facilities with steam supply of 600t/h and electric output of 55MW at Beijing Yanshan Petrochemical Co., China. In Plan A, fuel is changed from heavy oil to natural gas, and two heavy oil boilers are replaced with two gas turbines and two exhaust heat recovery steam generators for steam supply of 241t/h per unit and electric output of 136.9MW per unit. In Plan B, the boilers are replaced with three gas turbines and three exhaust heat recovery steam generators for steam supply of 210t/h per unit and electric output of 79.5MW per unit. The initial investment is 700 million yuan {+-} 100 million yuan in Plan A, and 500 million yuan {+-} 100 million yuan in Plan B. The generating cost is 0.403 yuan/kWh in Plan A, and 0.455 yuan/kWh in Plan B. It was concluded that without Plan A, the project will not be economically successful. In Plan A, the energy conservation will be 887,847 toe/y heavy oil equivalent, which increases productivity. Further, the amount of greenhouse effect gas emissions will be 2,747,187 t-CO2/y. (NEDO)

  4. Differentiation of Cuscuta chinensis and Cuscuta australis by HPLC-DAD-MS analysis and HPLC-UV quantitation.

    Science.gov (United States)

    He, Xianghui; Yang, Wenzhi; Ye, Min; Wang, Qing; Guo, Dean

    2011-11-01

    Cuscuta chinensis and Cuscuta australis, the two botanical sources of the Chinese herbal medicine Tu-Si-Zi, were distinguished from each other based on qualitative and quantitative chemical analysis. By HPLC‑DAD‑MS, a total of 36 compounds were characterized from these two Cuscuta species, including 14 flavonoids, 17 quinic acid derivatives, and 5 lignans. In addition, HPLC‑UV was applied to determine seven major compounds (6 flavonoids plus chlorogenic acid) in 27 batches of Tu-Si-Zi. The results revealed that the amounts of the three classes of compounds varied significantly between the species. C. australis contained more flavonoids but less quinic acid derivatives and lignans than C. chinensis. Particularly, the amounts of kaempferol and astragalin in C. australis were remarkably higher than in C. chinensis. This finding could be valuable for the quality control of Tu-Si-Zi. © Georg Thieme Verlag KG Stuttgart · New York.

  5. Probabilistic mapping of deep brain stimulation effects in essential tremor

    Directory of Open Access Journals (Sweden)

    Till A Dembek

    2017-01-01

    Discussion: Our results support the assumption, that the ZI might be a very effective target for tremor suppression. However stimulation inside the ZI and in its close vicinity was also related to the occurrence of stimulation-induced side-effects, so it remains unclear whether the VIM or the ZI is the overall better target. The study demonstrates the use of PSMs for target selection and evaluation. While their accuracy has to be carefully discussed, they can improve the understanding of DBS effects and can be of use for other DBS targets in the therapy of neurological or psychiatric disorders as well. Furthermore they provide a priori information about expected DBS effects in a certain region and might be helpful to clinicians in programming DBS devices in the future.

  6. Phytochemical, Antimicrobial, and Toxicological Evaluation of Traditional Herbs Used to Treat Sore Throat

    Directory of Open Access Journals (Sweden)

    Arifa Mehreen

    2016-01-01

    Full Text Available The in vitro antibacterial activities of 29 traditional medicinal plants used in respiratory ailments were assessed on multidrug resistant Gram-positive and Gram-negative bacteria isolated from the sore throat patients and two reference strains. The methanolic, n-hexane, and aqueous extracts were screened by the agar well diffusion assay. Bioactive fractions of effective extracts were identified on TLC coupled with bioautography, while their toxicity was determined using haemolytic assay against human erythrocytes. Qualitative and quantitative phytochemical analysis of effective extracts was also performed. Methanolic extract of 18 plants showed antimicrobial activity against test strains. Adhatoda vasica (ZI = 17–21 mm, MIC: 7.12–62.5 μg/mL, Althaea officinalis (ZI = 16–20 mm, MIC: 15.62–31.25 μg/mL, Cordia latifolia (ZI = 16–20 mm, MIC: 12.62–62.5 μg/mL, Origanum vulgare (ZI = 20–22 mm, MIC: 3–15.62 μg/mL, Thymus vulgaris (ZI = 21–25 mm, MIC: 7.81–31.25 μg/mL, and Ziziphus jujuba (ZI = 14–20 mm, MIC: 7.81–31.25 μg/mL showed significant antibacterial activity. Alkaloid fractions of Adhatoda vasica, Cordia latifolia, and Origanum vulgare and flavonoid fraction of the Althaea officinalis, Origanum vulgare, Thymus Vulgaris, and Ziziphus jujuba exhibited antimicrobial activity. Effective plant extracts show 0.93–0.7% erythrocyte haemolysis. The results obtained from this study provide a scientific rationale for the traditional use of these herbs and laid the basis for future studies to explore novel antimicrobial compounds.

  7. Phytochemical, Antimicrobial, and Toxicological Evaluation of Traditional Herbs Used to Treat Sore Throat

    Science.gov (United States)

    Mehreen, Arifa; Waheed, Muzzamil; Liaqat, Iram; Arshad, Najma

    2016-01-01

    The in vitro antibacterial activities of 29 traditional medicinal plants used in respiratory ailments were assessed on multidrug resistant Gram-positive and Gram-negative bacteria isolated from the sore throat patients and two reference strains. The methanolic, n-hexane, and aqueous extracts were screened by the agar well diffusion assay. Bioactive fractions of effective extracts were identified on TLC coupled with bioautography, while their toxicity was determined using haemolytic assay against human erythrocytes. Qualitative and quantitative phytochemical analysis of effective extracts was also performed. Methanolic extract of 18 plants showed antimicrobial activity against test strains. Adhatoda vasica (ZI = 17–21 mm, MIC: 7.12–62.5 μg/mL), Althaea officinalis (ZI = 16–20 mm, MIC: 15.62–31.25 μg/mL), Cordia latifolia (ZI = 16–20 mm, MIC: 12.62–62.5 μg/mL), Origanum vulgare (ZI = 20–22 mm, MIC: 3–15.62 μg/mL), Thymus vulgaris (ZI = 21–25 mm, MIC: 7.81–31.25 μg/mL), and Ziziphus jujuba (ZI = 14–20 mm, MIC: 7.81–31.25 μg/mL) showed significant antibacterial activity. Alkaloid fractions of Adhatoda vasica, Cordia latifolia, and Origanum vulgare and flavonoid fraction of the Althaea officinalis, Origanum vulgare, Thymus Vulgaris, and Ziziphus jujuba exhibited antimicrobial activity. Effective plant extracts show 0.93–0.7% erythrocyte haemolysis. The results obtained from this study provide a scientific rationale for the traditional use of these herbs and laid the basis for future studies to explore novel antimicrobial compounds. PMID:27429983

  8. Spacecraft and Stellar Occultations by Turbulent Planetary Atmospheres. A Theoretical Investigation of Various Wave Propagation Effects and Their Impact on Derived Profiles of Refractivity, Temperature and Pressure,

    Science.gov (United States)

    1981-05-08

    by writing the electric field observer approaches the focal as E = A exp I i(kS - wt) 1, where A is le in the plane ofthc sky the amplitude and kS...lowest-order correction to the electric field E. Writing z- [@ (Yi-Yo) 2 + o (zI -z 0 c 0 (zI - o) 3 4c 2 (z, -Zo) 2 (, -yo) + ... (3.14) it is...si ellair oc cult at ions when t It(- tcondit ions leadlIn-,, to equation (7.2) are satisfied. Thus equtins 17. 1) and( ( 7.2) ielt the( vatriance

  9. Helicopter Controllability

    Science.gov (United States)

    1989-09-01

    106 3. Program CC Systems Technology, Inc. (STI) of Hawthorne, CA., develops and markets PC control system analysis and design software including...is marketed in Palo Alto, Ca., by Applied i and can be used for both linear and non- linear control system analysis. Using TUTSIM involves developing...gravity centroid ( ucg ) can be calculated as 112 n m pi - 2 zi acg n i (7-5) where pi = poles zi = zeroes n = number of poles m = number of zeroes If K

  10. A Sociolinguistic Assessment of the Darwazi Speech Variety in Afghanistan

    Directory of Open Access Journals (Sweden)

    Simone Beck

    2013-01-01

    Full Text Available This paper presents a sociolinguistic assessment of the Darwāzi speech varieties (including Tangshewi based on data collected during a survey conducted between August 31st and September 19th 2008 in the Darwāz area. The research was carried out under the auspices of the International Assistance Mission, a Non-Governmental Organization working in Afghanistan. The goal was to determine whether Dari, one of the two national languages, is adequate to be used in literature and primary school education, or whether the Darwāzi people would benefit from language development, including literature development and primary school education in the vernacular.

  11. Modeling Turbulence Generation in the Atmospheric Surface and Boundary Layers

    Science.gov (United States)

    2015-10-01

    hydrostatic equation: dP dz = −ρa g −→ ∫ ZI 0 ρa dz = − 1 g ∫ dP = + 1 g [P (0)− P (ZI)]. (6.14) The pressure at the surface is... surface pressure is estimated, we can compute a vertical pressure profile using the hydrostatic equation and a selected temperature profile based on dP... surface -layer atmosphere. By surface layer what is intended is a layer of foliage plus the surface itself. That is, a flat ground surface that

  12. Economic burden of illness among US patients experiencing fracture nonunion

    Directory of Open Access Journals (Sweden)

    Wu N

    2013-03-01

    Full Text Available Ning Wu,1 Yuan-chi Lee,1 Daniel Segina,2 Hallie Murray,3 Teresa Wilcox,1 Luke Boulanger1 1United BioSource Corporation, Lexington, MA, USA; 2Department of Orthopaedics, Holmes Regional Trauma Center, Melbourne, FL, USA; 3Biomet Spine and Bone Healing Technologies, Parsippany, NJ, USA Objectives: To compare economic outcomes in a real-world study of patients with fracture nonunion receiving non-invasive electrical bone growth stimulation (EBGS, low-intensity pulsed ultrasound stimulation (LIPUS, or other non-stimulation fracture management interventions (No-stim. Methods: Medical and pharmacy claims from a US commercially-insured population were analyzed to select adult patients newly diagnosed with a fracture nonunion between July 2006 and September 2009. The date of initial nonunion diagnosis was set as the index date. Three cohorts were constructed based on the first treatment prescribed post index date: EBGS, LIPUS, or No-stim. Baseline demographics, clinical characteristics, and health care costs 9 months before and 1 year after the index date were assessed. Multivariate regression analyses were performed to compare health care costs between cohorts in the post index period. Results: 11,628 patients (mean age 45.4 years; 45.7% males with a fracture nonunion were identified within the three treatment groups (EBGS: 29.5%, LIPUS: 12.3%, and No-stim: 58.2%. In the post-index period, EBGS patients were significantly less likely to receive fracture-related treatments when compared to the LIPUS (33.6% vs 42.2%, P < 0.01 and the No-stim (33.6% vs 60.3%, P < 0.01 cohorts. Additionally, after adjusting for demographic and clinical characteristics, the EBGS cohort had significantly lower predicted health care-associated costs 1 year post index date when compared to the LIPUS (mean: $21,632 vs $23,964, P < 0.01 and the No-stim (mean: $21,632 vs $23,843, P < 0.01 cohorts. Furthermore, the predicted fracture-related costs (FRC of EBGS patients were also

  13. Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis

    Directory of Open Access Journals (Sweden)

    Zhou X

    2018-05-01

    Full Text Available Xian-guo Zhou,1,2,* Xiao-liang Huang,1,2,* Si-yuan Liang,1–3 Shao-mei Tang,1,2 Si-kao Wu,1,2 Tong-tong Huang,1,2 Zeng-nan Mo,1,2,4 Qiu-yan Wang1,2,5 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 4Department of Urology and Nephrology, The First Affiliated Hospital of Guangxi, Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 5Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China *These authors contributed equally to this work Introduction: Colorectal cancer (CRC is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA and gene modules or representative biomarkers related to the pathological stage of colon cancer helps to predict prognosis and reveal the mechanisms behind cancer progression.Materials and methods: We applied a systems biology approach by combining differential expression analysis and weighted gene co-expression network analysis (WGCNA to detect the pathological stage-related miRNA and gene modules and construct a miRNA–gene network. The Cancer Genome Atlas (TCGA colon adenocarcinoma (CAC RNA-sequencing data and miRNA-sequencing data were subjected to WGCNA analysis, and the GSE29623, GSE35602 and GSE39396 were utilized to validate and

  14. Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Chen TX

    2018-01-01

    Full Text Available Tian-Xiang Chen,1 Bigyan Pudasaini,1 Jian Guo,2 Su-Gang Gong,1 Rong Jiang,1 Lan Wang,1 Qin-Hua Zhao,1 Wen-Hui Wu,1 Ping Yuan,1 Jin-Ming Liu1 1Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, Shanghai, People’s Republic of China; 2Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University, Shanghai, People’s Republic of China Background: Sex differences in chronic thromboembolic pulmonary hypertension (CTEPH have been revealed in few studies. Although right heart catheterization (RHC is the gold standard for clinical diagnosis and assessment of prognosis in pulmonary hypertension (PH, cardiopulmonary exercise testing (CPET has been a more widely used assessment of functional capacity, disease severity, prognosis, and treatment response in PH. We hypothesized that the “sex-specific” CPET indices could estimate the severity of inoperable CTEPH.Methods: Data were retrieved for 33 male (age, mean ± standard deviation [SD] =62.5±13.4 years and 40 female (age, mean ± SD =56.3±11.8 years patients with stable CTEPH who underwent both RHC and CPET at Shanghai Pulmonary Hospital from February 2010 to February 2016. Univariate and forward/backward multiple stepwise regression analysis was performed to assess the predictive value of CPET indices to hemodynamic parameters. Event-free survival was estimated using the Kaplan–Meier method and analyzed with the log-rank test. Cox proportional hazards models were performed to determine the independent event-free survival predictors.Results: Numerous CPET parameters were different between male and female patients with CTEPH and the control group. There were no significant differences in both clinical variables and RHC parameters between male and female patients with CTEPH. O2 pulse, workload, minute ventilation (VE, and end-tidal partial pressure of O2 (PETO2 at anaerobic threshold, as well as peak O2 pulse, workload, VE, and nadir

  15. Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-α for infantile hemangioma

    Directory of Open Access Journals (Sweden)

    Zhang L

    2017-07-01

    Full Text Available Ling Zhang,1 Hai Wei Wu,1 Weien Yuan,2 Jia Wei Zheng1 1Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Background: Infantile hemangiomas (IHs are the most common benign vascular tumor of infancy. They occur more frequently in female infants. The cause of hemangioma is currently unknown; however, current studies suggested the importance of estrogen (E2 signaling in hemangioma proliferation. Methods: Hemangioma-derived stem cells (HemSCs were cultured with estrogen for 48–72 h; the cell viability and proliferation were evaluated with the messenger RNA (mRNA and protein expression levels of fibroblast growth factor 2 (FGF2, vascular endothelial growth factor-A (VEGF-A and estrogen receptor-α (ER-α, by application of several in vitro assays, such as methyl thiazolyl tetrazolium (MTT, reverse transcriptase–polymerase chain reaction (RT-PCR, real-time PCR, enzyme-linked immunosorbent assay (ELISA and Western blotting. Also, the cell population’s response to external estrogen was investigated by in vivo experiments. HemSCs and human umbilical vein endothelial cells (HUVECs were mixed and injected subcutaneously into 20 flank of BALB/c-nu mice, which were randomly divided into 5 groups based on different E2 treatment doses (0, 0.01, 0.1 and 1 mg, respectively, 0.1 mg dimethyl sulfoxide (DMSO as control. Each group of mice were treated intramuscularly every week, then 2 and 4 weeks later, the subcutaneous implants were harvested and evaluated the tumor tissues with microvessel density (MVD assay and immunohistochemistry. Results: The study demonstrated that application of E2 increased the expression of FGF2, VEGF-A, and ER-α in HemSCs with the optimal concentration from 10−9 to 10−5 M. Two

  16. Role of estrogen in lung cancer based on the estrogen receptor-epithelial mesenchymal transduction signaling pathways

    Directory of Open Access Journals (Sweden)

    Zhao XZ

    2015-10-01

    Full Text Available Xiao-zhen Zhao,1,* Yu Liu,1,* Li-juan Zhou,1,* Zhong-qi Wang,1 Zhong-hua Wu,2 Xiao-yuan Yang31Department of Tumor, Longhua Hospital, 2Center of Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA*These authors contributed equally to this workBackground/aim: Estrogen is reported to promote the occurrence and development of several human cancers. Increasing evidence shows that most human lung tumors exert estrogen receptor expression. In the present study, we investigated the underlying mechanism of estrogen effect in lung cancer through estrogen receptor-epithelial–mesechymal-transition signaling pathways for the first time.Materials and methods: A total of 36 inbred C57BL/6 mice (18 male and 18 female were injected subcutaneously with human lung adenocarcinoma cell line, Lewis. After the lung tumor model was established, mice with lung adenocarcinoma were randomly divided into three groups for each sex (n=6, such as vehicle group, estrogen group, and estrogen plus tamoxifen group. The six groups of mice were sacrificed after 21 days of drug treatment. Tumor tissue was stripped and weighed, and tumor inhibition rate was calculated based on average tumor weight. Protein and messenger RNA (mRNA expressions of estrogen receptor α (ERα, estrogen receptor β (ERβ, phosphatidylinositol 3'-kinase (PI3K, AKT, E-cadherin, and vimentin were detected in both tumor tissue and lung tissue by using immunohistochemistry and real-time reverse transcription-polymerase chain reaction.Results: 1 For male mice: in the estrogen group, estrogen treatment significantly increased ERα protein and mRNA expressions in tumor tissue and protein expression of PI3K, AKT, and vimentin in both tumor tissue and lung tissue compared with the vehicle-treated group. Besides, m

  17. Did opening of the South China Sea impact development of the Asian Monsoon? Results from Oligocene microfossils, IODP Site U1435, northern South China Sea

    Science.gov (United States)

    Kulhanek, Denise K.; Su, Xin; Li, Qianyu; Gregory, Mitch; Warny, Sophie; Clift, Peter D.

    2016-04-01

    conditions. Warm-water indicators such as Discoaster and Sphenolithus are relatively common throughout the interval, with a small increase in abundance near the top of the section. On the other hand, species sensitive to nutrient and/or salinity conditions, such as Helicosphaera and Braarudosphaera, vary in abundance throughout the section. These variations may be linked to changes in rainfall intensity and runoff/nutrient input from the adjacent continent, reflecting variations in the monsoon. These records, together with other Oligocene records from the northern South China Sea, should help to shed light on variations in the Asian Monsoon during the transition from Greenhouse to Icehouse conditions in the Oligocene. References: Clift, P.D., Hodges, K.V., Heslop, D., Hannigan, R., Van Long, H., and Calves, G., 2008. Correlation of Himalayan exhumation rates and Asian monsoon intensity. Nature Geoscience, 1: 875-880. Guo, Z.T., Ruddiman, W.F., Hao, Q.Z., Wu, H.B., Qiao, Y.S., Zhu, R.X., Peng, S.Z., Wei, J.J., Yuan, B.Y., and Liu, T.S., 2002. Onset of Asian desertification by 22 Myr ago inferred from loess deposits in China. Nature, 416: 159-163. Licht, A., van Cappelle, M., Abels, H.A., Ladant, J.-B., Trabucho-Alexandre, J., France-Lanord, C., Donnadieu, Y., Vandenberghe, J., Rigaudier, T., Lécuyer, C., Terry Jr., D., Adriaens, R., Boura, A., Guo, Z., Aung Naing Soe, Quade, J., Dupont-Nivet, and Jaeger, J.-J., 2014. Asian monsoons in a late Eocene greenhouse world. Nature, 513: 501-506.

  18. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells

    Directory of Open Access Journals (Sweden)

    Yuan CX

    2015-03-01

    Full Text Available Chun-Xiu Yuan,1,2 Zhi-Wei Zhou,2,3 Yin-Xue Yang,4 Zhi-Xu He,3 Xueji Zhang,5 Dong Wang,6 Tianxing Yang,7 Si-Yuan Pan,8 Xiao-Wu Chen,9 Shu-Feng Zhou2 1Department of Oncology, General Hospital, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 4Department of Colorectal Surgery, General Hospital, Ningxia Medical University, Yinchuan, 5Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, 6Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 9Department of General Surgery, The First People’s Hospital of Shunde, Southern Medical University, Shunde, People’s Republic of China Abstract: Gastric cancer is the second leading cause of cancer-related death worldwide, with a poor response to current chemotherapy. Danusertib is a pan-inhibitor of the Aurora kinases and a third-generation Bcr-Abl tyrosine kinase inhibitor with potent anticancer effects, but its antitumor effect and underlying mechanisms in the treatment of human gastric cancer are unknown. This study aimed to investigate the effects of danusertib on cell growth, apoptosis, autophagy, and epithelial to mesenchymal transition and the molecular mechanisms involved in human gastric cancer AGS and NCI-N78 cells. The results showed that danusertib had potent growth-inhibitory, apoptosis-inducing, and

  19. Precooling and Warm-Up Effects on Time Trial Cycling During Heat Stress.

    Science.gov (United States)

    Al-Horani, Ramzi A; Wingo, Jonathan E; Ng, Jason; Bishop, Phillip; Richardson, Mark

    2018-02-01

    Heat stress limits endurance exercise performance. Combining precooling and warm-up prior to endurance exercise in the heat may exploit the benefits of both strategies while avoiding the potential negative consequences of each. This study tested the hypothesis that precooling combined with warm-up improves time trial cycling performance in the heat relative to either treatment alone. Nine healthy men completed three 16.1-km time trials in 33°C after: 1) precooling (ice slurry and ice vest) alone (PREC); 2) warm-up alone (WU); or 3) PREC plus WU (COMBO). Tre was lower after PREC compared to WU throughout exercise and lower than COMBO for the first 12 km; COMBO was lower than WU for the first 4 km. Tsk during PREC was lower than COMBO and WU for the first 8 km, and lower in COMBO than WU for the first 4 km. PREC lowered pre-exercise heart rate relative to COMBO and WU (68 ± 10, 106 ± 12, 101 ± 13 bpm, respectively), but it increased similarly during exercise. Local sweat rate (SR) was lower in PREC (0.1 ± 0.1 mg · cm-2 · min-1) than COMBO (0.5 ± 0.2 mg · cm-2 · min-1) and WU (0.6 ± 0.2 mg · cm-2 · min-1) for the first 4 km. Treatments did not differentially affect performance (PREC = 31.9 ± 1.9 min, COMBO = 32.6 ± 2.7 min, WU = 33.1 ± 2.9 min). We conclude precooling alone or with warm-up mitigated thermal strain during exercise, but did not significantly improve 16.1-km cycling time trial performance.Al-horani RA, Wingo JE, Ng J, Bishop P, Richardson M. Precooling and warm-up effects on time trial cycling during heat stress. Aerosp Med Hum Perform. 2018; 89(2):87-93.

  20. Evaluation of effectiveness in a novel wound healing ointment ...

    African Journals Online (AJOL)

    Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen ...

  1. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  2. On the Amortized Complexity of Zero Knowledge Protocols for Multiplicative Relations

    DEFF Research Database (Denmark)

    Cramer, Ronald; Damgård, Ivan Bjerre; Pastro, Valerio

    2012-01-01

    We present a protocol that allows to prove in zero-knowledge that committed values xi, yi, zi, i = 1,…,l satisfy xiyi = zi, where the values are taken from a finite field. For error probability 2− u the size of the proof is linear in u and only logarithmic in l. Therefore, for any fixed error...... theoretically secure. Using this type of commitments we obtain, in the preprocessing model, a perfect zero-knowledge interactive proof for circuit satisfiability of circuit C where the proof has size O(|C|). We then generalize our basic scheme to a protocol that verifies l instances of an algebraic circuit D...... over K with v inputs, in the following sense: given committed values xi,j and zi, with i = 1,…,l and j = 1,…,v, the prover shows that D(xi,1,…,xi,v) = zi for i = 1,…,l. The interesting property is that the amortized complexity of verifying one circuit only depends on the multiplicative depth...

  3. CARDIOVASCULAR EFFECTS AND CHANGES IN MIDBRAIN PERIAQUEDUCTAL GRAY NEURONAL-ACTIVITY INDUCED BY ELECTRICAL-STIMULATION OF THE HYPOTHALAMUS IN THE RAT

    NARCIS (Netherlands)

    VANDERPLAS, J; WIERSINGAPOST, JEC; MAES, FW; BOHUS, B

    1995-01-01

    The effects of low-intensity electrical stimulation of sites in the hypothalamus and zona incerta (ZI) on mean blood pressure (MBP), heart rate (HR), and neuronal activity in the midbrain periaqueductal gray (FAG) were investigated in rats. Longlasting depressor responses were elicited from 67 sites

  4. An n-dimensional pseudo-differential operator involving the Hankel ...

    Indian Academy of Sciences (India)

    ji =0 bji x. 2 ji +μ+1/2 i. (x−1 i ∂/∂xi )ri + ji. (x. −μ−1/2 i φ(x1,..., xn)). ⎞. ⎠ ,. (1.8) where the bji are constants depending only on μ. For i = 1, 2,..., n, let (xi , yi , zi ) ...

  5. Dual pathway for angiotensin II formation in human internal mammary arteries

    NARCIS (Netherlands)

    Voors, AA; Pinto, YM; Buikema, H; Urata, H; Oosterga, M; Roos, G; Grandjean, JG; Ganten, D; van Gilst, WH

    1 Angiotensin converting enzyme (ACE) is thought to be the main enzyme to convect antiotensin I to the vasoactive angiotensin II. Recently, in the human heart, it was found that the majority of angiotensin ZI formation was due to another enzyme, identified as human heart chymase. In the human

  6. The Impact of the Public Authorities’ Messages – the European Central Bank Case

    Directory of Open Access Journals (Sweden)

    Ioan Talpos

    2007-03-01

    Of course, the following core question still remains: “How sustainable could be the effects induced by the impact of different agency messages received by the various beneficiaries?” And this, because in the end “The one who knows does not speak and the one who speaks does not know” (LAO ZI - DAO DE JING.

  7. Swallowing Quality of Life After Zona Incerta Deep Brain Stimulation.

    Science.gov (United States)

    Sundstedt, Stina; Nordh, Erik; Linder, Jan; Hedström, Johanna; Finizia, Caterina; Olofsson, Katarina

    2017-02-01

    The management of Parkinson's disease (PD) has been improved, but management of signs like swallowing problems is still challenging. Deep brain stimulation (DBS) alleviates the cardinal motor symptoms and improves quality of life, but its effect on swallowing is not fully explored. The purpose of this study was to examine self-reported swallowing-specific quality of life before and after caudal zona incerta DBS (cZI DBS) in comparison with a control group. Nine PD patients (2 women and 7 men) completed the self-report Swallowing Quality of Life questionnaire (SWAL-QOL) before and 12 months after cZI DBS surgery. The postoperative data were compared to 9 controls. Median ages were 53 years (range, 40-70 years) for patients and 54 years (range, 42-72 years) for controls. No significant differences were found between the pre- or postoperative scores. The SWAL-QOL total scores did not differ significantly between PD patients and controls. The PD patients reported significantly lower scores in the burden subscale and the symptom scale. Patients with PD selected for cZI DBS showed good self-reported swallowing-specific quality of life, in many aspects equal to controls. The cZI DBS did not negatively affect swallowing-specific quality of life in this study.

  8. Pitch Variability in Patients with Parkinson's Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

    Science.gov (United States)

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; van Doorn, Jan

    2013-01-01

    Purpose: The purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson's disease (PD). Method: The authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight…

  9. Articulatory Closure Proficiency in Patients with Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus and Caudal Zona Incerta

    Science.gov (United States)

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik; van Doorn, Jan

    2014-01-01

    Purpose: The present study aimed at comparing the effects of deep brain stimulation (DBS) treatment of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) on the proficiency in achieving oral closure and release during plosive production of people with Parkinson's disease. Method: Nineteen patients participated preoperatively and…

  10. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate

    Directory of Open Access Journals (Sweden)

    Fredrik Karlsson

    2011-01-01

    Full Text Available The hypokinetic dysarthria observed in Parkinson's disease (PD affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS of the subthalamic nucleus (STN-DBS and of the caudal zona incerta (cZi-DBS are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients and cZi-DBS (7 patients in two articulatory diadochokinesis tasks (AMR and SMR using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric. The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS.

  11. Versal deformation of the Lie algebra $L_2$

    NARCIS (Netherlands)

    Fialowski, A.; Post, Gerhard F.

    1999-01-01

    We investigate deformations of the infinite dimensional vector field Lie algebra spanned by the fields $e_i = z^{i+1}d/dz$, where $i \\ge 2 $. The goal is to describe the base of a ``versal'' deformation; such a versal deformation induces all the other nonequivalent deformations and solves the

  12. Versal deformation of the Lie algebra L_2

    NARCIS (Netherlands)

    Post, Gerhard F.; Fialowski, Alice

    2001-01-01

    We investigate deformations of the infinite-dimensional vector-field Lie algebra spanned by the fields ei = zi + 1d/dz, where i ≥ 2. The goal is to describe the base of a “versal” deformation; such a versal deformation induces all the other nonequivalent deformations and solves the deformation

  13. Fulltext PDF

    Indian Academy of Sciences (India)

    all polynomials in a variable X with coefficients in any commutative ring A is itself a ... integers denoted by Z[i] where i is a fixed square root of. -1 in C. The Gaussian ... aim of algebraic number theory is to understand how usual prime numbers ...

  14. Observed development of the vertical structure of the marine boundary layer during the LASIE experiment in the Ligurian Sea

    DEFF Research Database (Denmark)

    Sempreviva, Anna Maria; Schiano, M.E.; Pensieri, S.

    2010-01-01

    sensors mounted on the buoy ODAS Italia1 located in the centre of the Gulf of Genoa. The evolution of the height (zi) of the MABL was monitored using radiosondes and a ceilometer on board of the N/O Urania. Here, we present the database and an uncommon case study of the evolution of the vertical structure...

  15. Design, Implementation and Evaluation of an Operating System for a Network of Transputers.

    Science.gov (United States)

    1987-06-01

    WHILE TRUE -- listen to linki SEQ receiving the header BYTE.SLICE.INPUT (linkl,headerl,1,header.size) -- decoding the block size block.sizelLO] z...I’m done BYTE.SLICE.OUTPUT (screen[0] ,header0,3,1) WHILE TRUE -- listen to linki SEQ- rec eiving the header BYTE.SLICE. IPUT (linkl,headerl,1

  16. AHP 10: Story: A Stolen Journey

    Directory of Open Access Journals (Sweden)

    Blo bzang tshe ring བློ་བཟང་ཚེ་རིང་།

    2011-06-01

    Full Text Available BIo bzang tshe ring (b 1984 is from A mgon Village, A mchog Town, Bsang chu County, Kan Iho Tibetan Autonomous Prefecture, Kan su'u Province. He says, "I wrote this story based on what I was told by the three men who brought the main character of the story to Zi ling City in their car."

  17. The effect of torrefaction on oil palm empty fruit bunch properties ...

    African Journals Online (AJOL)

    The effect of torrefaction on oil palm empty fruit bunch properties using microwave irradiation. M.I. Ahmad, Z.I. Rizman, M.S.M. Rasat, Z.A.Z. Alauddin, S.N.M. Soid, M.S.A. Aziz, M. Mohamed, M.H.M. Amini, M.F.M. Amin ...

  18. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. ZI-JING ZHANG. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ...

  19. jingjing tan

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. JINGJING TAN. Articles written in Sadhana. Volume 43 Issue 4 April 2018 pp 56. Swept blade influence on aerodynamic performance of steam turbine nozzle cascades · ZI-MING FENG JINGJING TAN XIAOLEI LIU CUI WEI · More Details Abstract Fulltext PDF. To improve the aerodynamic ...

  20. Fulltext PDF

    Indian Academy of Sciences (India)

    The decimal digits Xi and hence the functions Zi sat- isfy a property which is essentially probabilistic in na- ture. We shall explain this, though we do not use any probabilistic results. Suppose you have a bag containing three red balls and two black balls. If you pick a ball at random, what are the chances that it is red?

  1. Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain.

    Science.gov (United States)

    Whitt, Jessica L; Masri, Radi; Pulimood, Nisha S; Keller, Asaf

    2013-02-27

    Spinal cord injury (SCI) results not only in motor deficits, but produces, in many patients, excruciating chronic pain (SCI pain). We have previously shown, in a rodent model, that SCI causes suppression of activity in the GABAergic nucleus, the zona incerta (ZI), and concomitant increased activity in one of its main targets, the posterior nucleus of the thalamus (PO); the increased PO activity is correlated with the maintenance and expression of hyperalgesia after SCI. Here, we test the hypothesis that SCI causes a similar pathological increase in other thalamic nuclei regulated by the ZI, specifically the mediodorsal thalamus (MD), which is involved in the emotional-affective aspects of pain. We recorded single and multiunit activity from MD of either anesthetized or awake rats, and compared data from rats with SCI with data from sham-operated controls (anesthetized experiments) or with data from the same animals prelesion (awake experiments). Consistent with our hypothesis, MD neurons from rats with SCI show significant increases in spontaneous firing rates and in the magnitude and duration of responses to noxious stimuli. In a subset of anesthetized animals, similar changes in activity of MD neurons were produced by pharmacologically inactivating ZI in naive rats, suggesting that the changes in the MD after SCI are related to suppressed inhibition from the ZI. These data support our hypothesis that SCI pain results, at least in part, from a loss of inhibition to thalamic nuclei associated with both the sensory-discriminative and emotional-affective components of pain.

  2. Zero inflated Poisson and negative binomial regression models: application in education.

    Science.gov (United States)

    Salehi, Masoud; Roudbari, Masoud

    2015-01-01

    The number of failed courses and semesters in students are indicators of their performance. These amounts have zero inflated (ZI) distributions. Using ZI Poisson and negative binomial distributions we can model these count data to find the associated factors and estimate the parameters. This study aims at to investigate the important factors related to the educational performance of students. This cross-sectional study performed in 2008-2009 at Iran University of Medical Sciences (IUMS) with a population of almost 6000 students, 670 students selected using stratified random sampling. The educational and demographical data were collected using the University records. The study design was approved at IUMS and the students' data kept confidential. The descriptive statistics and ZI Poisson and negative binomial regressions were used to analyze the data. The data were analyzed using STATA. In the number of failed semesters, Poisson and negative binomial distributions with ZI, students' total average and quota system had the most roles. For the number of failed courses, total average, and being in undergraduate or master levels had the most effect in both models. In all models the total average have the most effect on the number of failed courses or semesters. The next important factor is quota system in failed semester and undergraduate and master levels in failed courses. Therefore, average has an important inverse effect on the numbers of failed courses and semester.

  3. The Leibniz-Hopf algebra and Lyndon words

    NARCIS (Netherlands)

    M. Hazewinkel (Michiel)

    1996-01-01

    textabstractLet ${cal Z$ denote the free associative algebra ${ol Z langle Z_1 , Z_2 , ldots rangle$ over the integers. This algebra carries a Hopf algebra structure for which the comultiplication is $Z_n mapsto Sigma_{i+j=n Z_i otimes Z_j$. This the noncommutative Leibniz-Hopf algebra. It carries a

  4. Relationships between Arachidonic Acid, Uterine Activity and Metabolic Regulation of Placental Lactogen Secretion.

    Science.gov (United States)

    1982-08-01

    and R.E. Fellows. 1976. Circulating placental lactogen levels in dairy and beef cattle . Endocrinology 99:1273. Brinsmead, M.W., B.J. Bancroft, G.D... castrate sows. Am. J. Physiol. 217:1431. Felber, J.P., N. Zaragza, M. Benu7zi-Badoni and A.R. Genazzani. 1972. The double effect of HCS and pregnancy

  5. Fabrication and characterization of PDLLA/pyrite composite bone ...

    Indian Academy of Sciences (India)

    Keywords. Polylactic acid; Chinese herbal medicine; pyrite; scaffold; bone regeneration; cell culture. ... Pyrite (FeS2, named as Zi-Ran-Tong in Chinese medicine), as a traditional Chinesemedicine, has been used in the Chinese population to treat bone diseases and to promote bone healing. The mechanical properties of ...

  6. Seasonal ice dynamics of the Northeast Greenland Ice Stream

    DEFF Research Database (Denmark)

    Vijay, Saurabh; Khan, Shfaqat Abbas; Simonsen, Sebastian Bjerregaard

    2018-01-01

    and temporal details. This study focus on the Northeast Greenland Ice Stream (NEGIS), which consists of three main outlets, 79 North glacier (79N), Zachariae Isstrøm (ZI) and Storstrømmen Glacier (SG). While both 79 North and Storstrømmen have floating tongues, Zachariae Isstrøm is mostly grounded...

  7. Author Details

    African Journals Online (AJOL)

    Zhang, Zi-Ran. Vol 14, No 1 (2017) - Articles Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  8. Testing reachability and stabilizability of systems over polynomial rings using Gröbner bases

    NARCIS (Netherlands)

    Habets, L.C.G.J.M.

    1993-01-01

    Conditions for the reachability and stabilizability of systems over polynomial rings are well-known in the literature. For a system $ \\Sigma = (A,B)$ they can be expressed as right-invertibility cconditions on the matrix $(zI - A \\mid B)$. Therefore there is quite a strong algebraic relationship

  9. In vitro antibacterial activity of methanol and water extracts of adiantum capillus veneris and tagetes patula against multidrug resistant bacterial strains

    International Nuclear Information System (INIS)

    Hussain, M.M.; Ahmad, B.; Bashid, E.; Hashim, S.

    2014-01-01

    The aim of present study was to screen the antimicrobial activities of extracts of leaves and stems of Adiantum capillus veneris and Tagetes patula against multidrug-resistant (MDR) bacterial strains. Extracts from the leaves and stems of these plants were extracted with methanol and water and tested for their antibacterial activity by disc diffusion method against ten MDR bacterial strains i.e., Citrobacter freundii, Escherichia coli, Providencia, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, Salmonella typhi, Shigella and Vibrio cholerae. Leaves methanol extract (LME) of Adiantum showed maximum Zone of Inhibition (ZI) against Providencia, Klebsiella pneumoniae, Shigella, Vibrio cholerae, Staphylococcus aureus, Proteus vulgaris and Salmonella typhi, whereas its stem methanol extract (SME) was very active against Escherichia coli, Klebsiella pneumoniae and Salmonella typhi. Similarly LME of Tagetes showed highest ZI against Escherichia coli and Vibrio cholerae while SME showed highest ZI to Escherichia coli, Vibrio cholerae, Providencia, Shigella and Klebsiella pneumoniae. Leaves water extract (LWE) of Adiantum was very active against all ten bacterial strains while its stem water extract (SWE) showed maximum ZI against Escherichia coli, Klebsiella pneumoniae and Salmonella typhi, Shigella, Proteus vulgaris and Providencia. LWE of Tagetes was only active against Vibrio cholerae whereas SWE was very active against Salmonella typhi and active against P. vulgaris, Citrobacter freundii and Vibrio cholerae. It was concluded from this study that extracts of both Adiantum and Tagetes have prominent activities against most of the MDR bacterial strains and needs further studies for utmost benefits. (author)

  10. Highland Medical Research Journal - Vol 14, No 2 (2014)

    African Journals Online (AJOL)

    Knowledge of malaria and practice of home management of malaria among mothers of under fives · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. ZI Hassan, TO Afolaranmi, YO Tagurum, HA Agbo, HM Sule, 58-62 ...

  11. The good and bad of stress : implications for memory and adaptive processes

    NARCIS (Netherlands)

    Wichmann, Romy

    2012-01-01

    Stress spedt een steeds grotere rol in onze moderne samenleving. Iedereen is er ooit mee geconfronteerd en moet ermee omgaan. Echter hoeft stress niet noodzakelijk slecht te zi.in. Op de korte termiin kan stress, of de lichamelijke reactie op stress, ons helpen om in tijden van druk beter te

  12. Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies

    Energy Technology Data Exchange (ETDEWEB)

    Best, Katharine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Guedj, Jeremie [Univ. of Paris (France). IAME; Madelain, Vincent [Univ. of Paris (France); de Lamballerie, Xavier [Aix-Marseille Univ. (France); L, So-Yonim [Harvard Univ., Cambridge, MA (United States). Center for Virology and Vaccine Research; Osuna, Christa E [Harvard Univ., Cambridge, MA (United States). Center for Virology and Vaccine Research; Whitney, James [Harvard Univ., Cambridge, MA (United States). Center for Virology and Vaccine Research; Perelson, Alan S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-24

    The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.

  13. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Hongling Wang. Articles written in Journal of Chemical Sciences. Volume 120 Issue 4 July 2008 pp 419-424. Microdetermination of human serum albumin by differential pulse voltammetry at a L-cysteine modified silver electrode · Liyuan Lu Yanqin Zi Hongling Wang.

  14. Convective Ignition of Propellant Cylinders in a Developing Cross-Flow Field.

    Science.gov (United States)

    1980-09-01

    measurements are required to identify surface dynamics phenomena, e.g., infrared pyrometer and high-speed photomicrography of the burning surface. (10...tcle W-V a Dv. rc The resistance R corresponds to open end acoustic radiation. Zi are the impedances of thi elements J. W is the frequency of Po- The

  15. ORTHOIMAGERY, MANATEE COUNTY, FL, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The 8-bit 3-Band (Red, Green, Blue) one-foot orthophotos were flown with a Z/I Intergraph DMC airborne digital sensor. The flight season was from December 15, 2008...

  16. Comparative study on calcium, magnesium and cobalt in diabetic ...

    African Journals Online (AJOL)

    Comparative study on calcium, magnesium and cobalt in diabetic and non diabetic patients (males) in Punjab, Pakistan. A Anjum, M Yousaf, M Zuber, HB Ahmad, AF Zahoor, ZI Khan, K Ahmad, S Naheed, KG Ali, A Jabbar, TH Bukhari, S Hina, S Ahmad, MK Mukhtar, M Arshad, A Hussain ...

  17. Zinc treatment increases the titre of ‘Candidatus Liberibacter asiaticus’ in Huanglongbing-affected citrus plants while affecting the bacterial microbiomes

    Science.gov (United States)

    Huanglongbing (HLB)-affected citrus often display zinc deficiency symptoms. In this study, supplemental zinc was applied to citrus to determine its effect on Candidatus Liberibacter asiaticus (Las) titer, HLB symptoms, and leaf microbiome. HLB-affected citrus were treated with various amounts of zi...

  18. People’s Republic of China Scientific Abstracts, Number 177

    Science.gov (United States)

    1977-10-06

    PAO [ARCHITECTURAL JOURNAL] No 2, June 1977 1 CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] No 4, December 1976 13 CHIH-WU TSA-CHIH [JOURNAL OF BOTANY...10424 CSO: 4009 12 ACTA BOTANICA SINICA AUTHOR: None ORG: Three-in-one Combination Experimental Group of Peking Ch’ung-wen Vegetable Station...Physiological Processes of Stored Tomatoes" SOURCE: Peking CHIH-WU HSUEH-PAO [ACTA BOTANICA SINICA] in Chinese Vol 18, No 4, Dec 76 pp 278-283 TEXT OF

  19. The Role of Retinal Determination Gene Network (RDGN) in Hormone Signaling Transduction and Prostate Tumorigenesis

    Science.gov (United States)

    2013-10-01

    Wu K, Wang L, Jiao X, Ju X, Li Z, Ertel A, Addya S, McCue P, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG. Androgen therapy resistant...Li Z, Hu J, Chen K, Wu J, Pestell RG. DACH1 inhibited prostate cancer cellular proliferation and Interleukon-6 signaling. AACR 103rd Annual Meeting...March 31 – April 4, 2012, Chicago, IL.  Wang J, Cai S, Chen K, Sun Y, Li S, Pestell RG, Wu K. Regulation of AR transcriptional activity and

  20. On the optimum processing conditions of Pb(Zr x Ti1-x )O3: revealing the mechanisms to increase the piezoelectric coefficients up to 1100 pm V-1

    Science.gov (United States)

    Zeibekis, M.; Vertsioti, G.; Stamopoulos, D.

    2016-03-01

    The ferroelectric compound family Pb(Zr x Ti1-x )O3 (PZT) is one of the most investigated and widely used piezoelectric materials. Optimization of the piezoelectric coefficients is observed for x ~ 0.52 (Pb(Zr0.52Ti0.48)O3) and is further promoted by the increase of grain size (GS). However, in some cases the piezoelectric properties of Pb(Zr0.52Ti0.48)O3 deteriorate upon processing due to the decrease of density, ρ, that is mostly ascribed to the appearance of byproduct phases. In the present study we discuss the influence of the processing conditions on the piezoelectric properties for polycrystalline Pb(Zr0.52Ti0.48)O3, specifically focusing on the sintering temperature, 1100 °C  ⩽  T sin  ⩽  1250 °C. To this end, we use atomic force microscopy (AFM), Archimedes’ method, x-ray diffraction (XRD) and a newly introduced local technique, based on a conventional optical microscope, which is further developed here to accommodate non-clamped specimens. The data obtained via this technique in the regime of relatively high electric fields evidence that the absolute piezoelectric coefficients, |d zi | (i  =  x, y) show a non-monotonic behavior with an unexpectedly high maximum value |d zi | ~ 1100 pm V-1 at T sin  =  1180 °C. These features are accompanied by a progressive increase of coercivity, reaching maximum value E C,i ~ 4.5-5.0 kV cm-1 (i  =  x, y) at T sin  =  1250 °C. To explain these findings, the |d zi | coefficients are compared with the microstructure and compositional information, coming from AFM, Archimedes’ method and XRD data. We conclude that the significantly high |d zi | values observed for samples prepared at T sin  =  1180 °C are motivated by the increase of mean GS, , while for T sin  >  1180 °C the decrease of density, ρ, ascribed to the appearance of byproduct phases, dominates and deteriorates |d zi |. These experimental results on |d zi |(T sin) are reliably

  1. FOREWORD: 26th IAHR Symposium on Hydraulic Machinery and Systems

    Science.gov (United States)

    Wu, Yulin; Wang, Zhengwei; Liu, Shuhong; Yuan, Shouqi; Luo, Xingqi; Wang, Fujun

    2012-11-01

    the value of hydraulic machinery to the end user, to the societies, and to improve societies understanding and appreciation of that value. The series of IAHR Symposia on Hydraulic Machinery and Cavitation started with the 1st edition in Nice, France, 1960. For the past decade, all the symposia have focused on an extended portfolio of topics under the name of 'Hydraulic Machinery and Systems', such as the 20th edition in Charlotte, USA, 2000, the 21st in Lausanne, Switzerland, 2002, the 22nd in Stockholm, Sweden, 2004, the 23rd in Yokohama, Japan, 2006, the 24th in Foz do Iguassu, Brasil, 2008, and the 25th in Timisoara, Romania, 2010. The 26th IAHR Symposium on Hydraulic Machinery and Systems brings together more than 250 scientists and researchers from 25 countries, affiliated with universities, technology centers and industrial firms to debate topics related to advanced technologies for hydraulic machinery and systems, which will enhance the sustainable development of water resources and hydropower production. The Scientific Committee has selected 268 papers, out of 430 abstracts submitted, on the following topics: (i) Hydraulic Turbines and Pumps, (ii) Sustainable Hydropower, (iii) Hydraulic Systems, (iv) Advances in Computational and Experimental Techniques, (v) Application in Industries and in Special Conditions, to be presented at the symposium and to be included in the proceedings. All the papers, published in this Volume 15 of IOP Conference Series: Earth and Environmental Science, have been peer reviewed through processes administered by the editors of the 26th IAHR Symposium on Hydraulic Machinery and Systems proceedings, those are Yulin Wu, Zhengwei Wang, Shuhong Liu, Shouqi Yuan, Xingqi Luo and Fujun Wang. We sincerely hope that this edition of the symposium will be a significant step forward in the worldwide efforts to address the present challenges facing the modern Hydraulic Machinery and Systems. Professor Yulin Wu Chairman of the Organizing Committee

  2. Projections of Somatosensory Cortex and Frontal Eye Fields onto Incertotectal Neurons in the Cat

    Science.gov (United States)

    Perkins, Eddie; Warren, Susan; Lin, Rick C.-S.; May, Paul J.

    2014-01-01

    The goal of this study was to determine whether the input-output characteristics of the zona incerta (ZI) are appropriate for it to serve as a conduit for cortical control over saccade-related activity in the superior colliculus. The study utilized the neuronal tracers wheat germ agglutinin-horseradish peroxidase (WGA-HRP) and biotinylated dextran amine (BDA) in the cat. Injections of WGA-HRP into primary somatosensory cortex (SI) revealed sparse, widespread nontopographic projections throughout ZI. In addition, region-specific areas of more intense termination were present in ventral ZI, although strict topography was not observed. In comparison, the frontal eye fields (FEF) also projected sparsely throughout ZI, but terminated more heavily, medially, along the border between the two sublaminae. Furthermore, retrogradely labeled incertocortical neurons were observed in both experiments. The relationship of these two cortical projections to incertotectal cells was also directly examined by retrogradely labeling incertotectal cells with WGA-HRP in animals that had also received cortical BDA injections. Labeled axonal arbors from both SI and FEF had thin, sparsely branched axons with numerous en passant boutons. They formed numerous close associations with the somata and dendrites of WGA-HRP-labeled incertotectal cells. In summary, these results indicate that both sensory and motor cortical inputs to ZI display similar morphologies and distributions. In addition, both display close associations with incertotectal cells, suggesting direct synaptic contact. From these data, we conclude that inputs from somatosensory and FEF cortex both play a role in controlling gaze-related activity in the superior colliculus by way of the inhibitory incertotectal projection. PMID:17083121

  3. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Keratinocytes (HGKs).

    Science.gov (United States)

    Grenade, Charlotte; De Pauw-Gillet, Marie-Claire; Pirard, Catherine; Bertrand, Virginie; Charlier, Corinne; Vanheusden, Alain; Mainjot, Amélie

    2017-03-01

    Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD-CAM composites, is poorly explored in the literature, in particular, no data are available regarding Human Gingival Keratinocytes (HGK). The first objective of this study was to evaluate the in vitro biocompatibility of PICNs with HGKs in comparison with other materials typically used for implant prostheses. The second objective was to correlate results with PICN monomer release and indirect cytotoxicity. HGK attachment, proliferation and spreading on PICN, grade V titanium (Ti), yttrium zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control) discs were evaluated using a specific insert-based culture system. For PICN and eM samples, monomer release in the culture medium was quantified by high performance liquid chromatography and indirect cytotoxicity tests were performed. Ti and Zi exhibited the best results regarding HGK viability, number and coverage. eM showed inferior results while PICN showed statistically similar results to eM but also to Ti regarding cell number and to Ti and Zi regarding cell viability. No monomer release from PICN discs was found, nor indirect cytotoxicity, as for eM. The results confirmed the excellent behavior of Ti and Zi with gingival cells. Even if polymer based, PICN materials exhibited intermediate results between Ti-Zi and eM. These promising results could notably be explained by PICN high temperature-high pressure (HT-HP) innovative polymerization mode, as confirmed by the absence of monomer release and indirect cytotoxicity. Copyright © 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  4. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Lihua Jiang1 Aiyi Zhu1 Jianse Zhang1 Changwen Wu1. National Engineering Research Center of Marine Facilities Aquaculture, College of Marine Science, Zhejiang Ocean University, Zhoushan 316022, China ...

  5. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Use of artificial neural network for spatial rainfall analysis .... GIS and SBF for estimating groundwater recharge of a mountainous basin in the Wu River ... Hydrogeological and geophysical study for deeper groundwater resource in quartzitic ...

  6. Arsenic bioleaching in medical realgar ore and arsenic- bearing ...

    African Journals Online (AJOL)

    Oxidation of these two ores by sulfuric acid was insignificant, as maximum arsenic leaching ratios ... Poor water solubility and weak gastrointestinal absorption of coarse ..... Wu XH, Sun DH, Zhuang ZX, Wang XR, Gong HF, Hong. JX, Lee FSC.

  7. Combined usage of testosterone and nandrolone may cause heart ...

    African Journals Online (AJOL)

    User

    2011-05-09

    May 9, 2011 ... blood urea nitrogen were measured with an auto-analyzer. Combined use of ... lation of protein synthesis in an anabolic manner (Wu,. 1997; Basaria et .... Ayotte C (2006). Significance Of 19-norandrosterone in athletes' urine.

  8. 76 FR 6769 - Office of Postsecondary Education, Overview Information, Undergraduate International Studies and...

    Science.gov (United States)

    2011-02-08

    ... propose the development of area or international studies programs to include language instruction in any..., Burmese, Cebuano (Visayan), Chechen, Chinese (Cantonese), Chinese (Gan), Chinese (Mandarin), Chinese (Min), Chinese (Wu), Croatian, Dari, Dinka, Georgian, Gujarati, Hausa, Hebrew (Modern), Hindi, Igbo, Indonesian...

  9. Vaimse tervise ümarlaud - ühisüritus vaimse tervise heaks / Lauraliisa Heidmets, Merike Sisask

    Index Scriptorium Estoniae

    Heidmets, Lauraliisa

    2009-01-01

    Ülevaade Eesti-Rootsi Vaimse Tervise ja Suitsidoloogia Instituudi (ERSI), sotsiaalministeeriumi ja Tervise Arengu Instituudi (TAI) korraldatud ümarlauast. Ettekannetega esinesid ka TLÜ sotsioloogia doktorandid Merike Sisask, Jing Wu, Piret Visnapuu ning prof. Airi Värnik

  10. Stochastic quantization of the Kink solution of phi4 field theory

    International Nuclear Information System (INIS)

    Kates, R.; Rosenblum, A.

    1989-01-01

    The method of Parisi-Wu Stochastic quantization in quantum field theory is compared to earlier work in classical field equations. The method is applied to solve for the propagator for Phi 4 field theory by perturbing the Kink solution

  11. Marginal scorch caused by Alternaria alternata on Purple-Caitai ...

    African Journals Online (AJOL)

    Marginal scorch caused by Alternaria alternata on Purple-Caitai (Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee) in China. Qijun Nie, Zhongjiu Jiao, Fengjuan Zhu, Zhenbiao Jiao, Xiaohui Deng, Zhengming Qiu, Jinping Wu ...

  12. African Journal of Biotechnology - Vol 11, No 70 (2012)

    African Journals Online (AJOL)

    Embryogenesis and plant regeneration from unpollinated ovaries of Amorphophallus konjac · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Lingling Zhao, Jinping Wu, Ying Diao, Zhongli Hu, 13472-13476 ...

  13. Wyrtki Jets: Role of Intraseasonal forcing

    Indian Academy of Sciences (India)

    44

    2018-04-16

    Apr 16, 2018 ... and global climate system (Vinayachandran et al., 1999; Murtugudde and .... wind forcing influence the WJs? and how does this relate to its observed ...... Lau, K., and H. Wu, 2010: Characteristics of precipitation, cloud, and la-.

  14. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2018-03-07

    Mar 7, 2018 ... Faculty of Business, Multimedia University, 75450 Melaka, Malaysia ..... call-taxi App. In 25th Australasian Conference on Information Systems, 2014, pp. .... [31] Wu M. L. SPSS statistical application practice: Questionnaire ...

  15. Transfusion reaction - hemolytic

    Science.gov (United States)

    ... Names Blood transfusion reaction Images Surface proteins causing rejection References Choate JD, Maitta RW, Tormey CA, Wu ... PA: Elsevier Saunders; 2016:chap 177. Hall JE. Blood types; transfusion; tissue and organ transplantation. In: Hall JE, ...

  16. Total phenolic, condensed tannin and antioxidant activity of four ...

    African Journals Online (AJOL)

    Administrator

    2011-09-07

    Sep 7, 2011 ... the common fruits and vegetables across the US (Wu et al., 2004). ... or pellicle were separated from the shell by cracking with a small hammer ..... shell (Carya Illinoensis), pomegranate husk (Punica granatum) and creosote ...

  17. Peng et al., Afr J Tradit Complement Altern Med. (2015) 12(5):35-45 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    as a kind of specific application of syndrome differentiation, You Gu Wu Yun, documented .... Zhi-Zhu-Wan (ZZW), a famous Chinese medical preparation used to treat functional dyspepsia, contains Aurantii fructus ..... Abdominal pain, vomiting,.

  18. Protective effect of rhamnopyranosyl vanilloyl isolated from ...

    African Journals Online (AJOL)

    Cai Tian Di Wang in 2013 and authenticated by. Chang-Wu Wang, a ... purchased from Abcam (Cambridge, UK) and ..... Hosaka T, Suzuki F, Kobayashi M, Seko Y, Kawamura Y, ... Han JJ, Ning N. Research progress on pharmacological.

  19. Lyme Disease Tests

    Science.gov (United States)

    ... Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 1538. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, 12th Edition: Mosby Elsevier Press, St. Louis, MO. ...

  20. Fungal Tests

    Science.gov (United States)

    ... Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 1569, 1570, 1532, 1616. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, Twelfth Edition: Mosby Elsevier Press, St. Louis, Missouri. ...

  1. Chickenpox and Shingles Tests

    Science.gov (United States)

    ... Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests , Fourth Edition: Saunders Elsevier, St. Louis, MO. Pp 1623. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology , Twelfth Edition: Mosby Elsevier Press, St. Louis, MO. ...

  2. An MOT-TDIE solver for analyzing transient fields on graphene-based devices

    KAUST Repository

    Shi, Yifei; Li, Ping; Uysal, Ismail Enes; Ulku, Huseyin Arda; Bagci, Hakan

    2016-01-01

    -RBC) and Poggio-Miller-Chang-Harrington-Wu-Tsai (TD-PMCHWT) integral equation, which are enforced on the surfaces of the graphene and dielectric substrate, respectively. The expressions of the time domain resistivity and conductivity of the graphene sheet

  3. Pop / Andri Riid

    Index Scriptorium Estoniae

    Riid, Andri, 1972-

    2008-01-01

    Heliplaatidest: Nice Try "Nice Try", Wu Tang Clan "8 Diagrams", Niki "Äike päike", Röövel Ööbik "Popsubterranea", Tijuana Mon Amour Broadcasting Inc. "Cold Jubilee (of the Snowqueen), "Holy Fuck "LP"

  4. Synthesis and characterization of electrochemically-reduced graphene

    Indian Academy of Sciences (India)

    Keywords. Graphene; electrochemical deposition; heat treatment; conductivity. 1. Introduction ... solar cells (Wu et al 2008; Sima et al 2011), molecular gas sensors ... solved in deionized (DI) water to obtain 0·01 M of electrolyte solution (Su et ...

  5. Media and Security Team

    Data.gov (United States)

    Federal Laboratory Consortium — The Media And Security Team led by Prof. Min Wu was established in Fall 2001 at University of Maryland, College Park. A number of research and education activities...

  6. Genomewide analysis of MATE-type gene family in maize reveals ...

    Indian Academy of Sciences (India)

    Huasheng Zhu and Jiandong Wu contributed equally to this work. As a group of secondary active transporters, the MATE gene family consists of multiple genes that widely exist in ..... Roots of the stress-treated plants were collected at 0,.

  7. T'ai Chi

    Science.gov (United States)

    ... are different styles of t'ai chi, including: Chen style Hao (or Wu Shi) style Hu Lei ... medical advice, diagnoses, and treatment, consult your doctor. © 1995- The Nemours Foundation. All rights reserved. Images provided ...

  8. Autism and green space_clean

    Data.gov (United States)

    U.S. Environmental Protection Agency — Autism and green space metrics in California elementary school districts. This dataset is associated with the following publication: Wu, J., and L. Jackson. Inverse...

  9. African Journal of Biotechnology - Vol 5, No 6 (2006)

    African Journals Online (AJOL)

    -related protein kinase2 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Huawen Zou, Xiuhai Zhang, JiuRan Zhao, Qing Yang, Zhongyi Wu, Fengge Wang, Conglin Huang, 490-496 ...

  10. Transient analysis of plasmonic nanostructures using an MOT-PMCHWT solver

    KAUST Repository

    Uysal, Ismail Enes; Ulku, Huseyin Arda; Bagci, Hakan

    2015-01-01

    A marching on in time (MOT) scheme for solving the Poggio-Miller-Chan-Harrington-Wu-Tsai (PMCHWT) surface integral equation on plasmonic nanostructures is described. The proposed scheme calls for temporal convolutions of the permittivity and Green

  11. Biological and technological effects of some mulberry varieties and ...

    African Journals Online (AJOL)

    egyptian hak

    synthesize different types of antioxidant compounds and activate key ... the nutrient uptake of rice plants, especially phosphorous and potassium (Wu et al ... agricultural products and cause detrimental effects to environment and human health.

  12. Electromagnetic properties of low-spin states in 102,104Pd

    International Nuclear Information System (INIS)

    Luontama, M.; Julin, R.; Kantele, J.; Passoja, A.; Trzaska, W.; Baecklin, A.; Jonsson, N.G.; Westerberg, L.

    1985-12-01

    Electromagnetic transitions from low-lying 0 + , 2 + , 4 + and 3 - states in 102 , 104 Pd have been studied with (p,2n) and (p,p) reactions and with Coulomb excitation. The E2 transition probabilities from the 0 3 + state in 102 Pd (13 W.u.) and from the 0 2 + state in 104 Pd (14 W.u.) are somewhat low for two-phonon states. Generally, the E2 transition rates are reasonably well reproduced by the IBA-2 and by the boson-expansion description. The intruding 0 2 + state (tsub(1/2) = 14.3 ns) in 102 Pd is connected to the 2 2 + and 2 3 + states via strong E2 transitions: B(E2;0 2 + →2 2 + )=96+-40 W.u.; B(E2;2 3 + →0 2 + )=17+-8 W.u

  13. Distribution of organochlorine pesticides and polychlorinated ...

    African Journals Online (AJOL)

    SARAH

    2015-04-30

    Apr 30, 2015 ... compartments of the environment (soil, water, air.) (Wu et al., 1999, Jiang ... toxicity and bioaccumulation through the food chain and their long-range ... they are used for fisheries, aquaculture, touristic and transport activities.

  14. Drawing the Ethical Line

    Institute of Scientific and Technical Information of China (English)

    ADAMMINTER

    2004-01-01

    An American businessman with over ten years experience in China opens his wallet in the back of a Shanghai taxi. Inside are several blue and green Shanghai Public Transportation Cards stacked like credit cards. “At my wife's office, the vendors show up and hand these out as gifts,”he says as he hands one to the driver. “She can accept them because [the company's] gift policy limits gifts to two-hundred yuan, and the vendor only puts two-hundred yuan on the card.” He opens the door and steps onto a busy street frequented by Shanghai's foreign business community. “Now you tell me: is that bribe? For two hundred yuan? I don't think so. It's a gift between business partners. It's China,you know?”

  15. [Financial burden of hepatitis B-related diseases and factors influencing the costs in Shenzhen, China].

    Science.gov (United States)

    Liang, Sen; Zhang, Shun-xiang; Ma, Qi-shan; Xiao, He-wei; Lü, Qiu-ying; Xie, Xu; Mei, Shu-jiang; Hu, Dong-sheng; Zhou, Bo-ping; Li, Bing; Chen, Jing-fang; Cui, Fu-qiang; Wang, Fu-zhen; Liang, Xiao-feng

    2010-12-01

    To investigate the direct, indirect and intangible costs due to hepatitis B-related diseases and to explore main factors associated with the costs in Shenzhen. Cluster sampling for cases collected consecutively during the study period was administrated. Subjects were selected from eligible hepatitis B-related patients. By pre-trained professional investigators, health economics-related information was collected, using a structured questionnaire. Hospitalization expenses were obtained through hospital records after the patients were discharged from hospital. Total economic burden of hepatitis B-related patients would involve direct, indirect and intangible costs. Direct costs were further divided into direct medical costs and direct nonmedical costs. Human Capital Approach was employed to measure the indirect costs both on patients and the caregivers in 1-year time span. Willing to pay method was used to estimate the intangible costs. Multiple linear stepwise regression models were conducted to determine the factors linked to the economic burden. On average, the total annual cost of per patient with hepatitis B-related diseases was 81 590.23 RMB Yuan. Among which, direct, indirect and intangible costs were 30 914.79 Yuan (account for 37.9%), 15 258.01 Yuan (18.7%), 35 417.43 Yuan (43.4%), respectively. The total annual costs per patient for hepatocellular carcinoma, severe hepatitis B, decompensated cirrhosis, compensated cirrhosis, chronic hepatitis B and acute hepatitis B were 194 858.40 Yuan, 144 549.20 Yuan, 120 333.60 Yuan, 79 528.81 Yuan, 66 282.46 Yuan and 39 286.81 Yuan, respectively. The ratio of direct to indirect costs based on the base-case estimation foot add to 2.0:1, increased from hepato-cellular carcinoma (0.7:1) to compensated cirrhosis (3.5:1), followed by acute hepatitis B (3.3:1), severe hepatitis B (2.8:1), decompensate cirrhosis (2.3:1) and chronic hepatitis B (2.2:1). Direct medical costs were more than direct nonmedical. Ratio between the

  16. Developing institutional collaboration between Wageningen University and the Chinese Academy of Agricultural Sciences

    OpenAIRE

    Bonnema, A.B.; Lin, Zhai; Qu, Liang; Jacobsen, E.

    2006-01-01

    Scientific co-operation between the Chinese Academy of Agricultural Sciences (CAAS) and Wageningen University (WU) has been underway since 1990, especially in the field of plant sciences. In 2001, CAAS and WU initiated a formal joint PhD training programme to further structure their co-operation. The goals of this co-operation are to: (1) initiate long-term institutional collaboration through capacity building; (2) jointly establish a modern laboratory; (3) jointly develop a cross-cultural sc...

  17. Effects of Estradiol on Post-Traumatic Stress Disorder Symptoms

    Science.gov (United States)

    2010-03-01

    Directed By: T. John Wu, Ph.D. Associate Professor, Department of Obstetrics and Gynecology Post-traumatic stress disorder (PTSD) is a complex...Preventing post-traumatic stress disorder after mass exposure to violence . Biosecur Bioterror 2005;3:154-63; discussion 64-5. 16. Baker DG...John Wu* Affiliations: *Program in Neuroscience and § Program in Molecular and Cellular Biology, Department of Obstetrics and Gynecology Uniformed

  18. New species and new records of Amphinemurinae (Plecoptera: Nemouridae) from Shaanxi Province of China.

    Science.gov (United States)

    Li, Weihai; Dong, Wenbin; Yang, Ding

    2018-03-27

    Three new species of the Amphinemurinae genus Amphinemura, A. dicroidea sp. nov., A. longihamita sp. nov. and A. microhamita sp. nov., are described from China. These new species are compared with related taxa. Amphinemura multispina (Wu) and Sphaeronemoura grandicauda (Wu) (also belonging to the Amphinemurinae) are recorded from Shaanxi Province, northwestern China for the first time. The adult male of A. multispina is redescribed and the adult female of S. grandicauda is also described based on new material.

  19. A comparative survey of the condition of tourism infrastructure in Iranian provinces using VIKOR and TOPSIS

    OpenAIRE

    Moslem Bagheri; Payam Shojaei; Maryam Tayebi Khorami

    2018-01-01

    Tourism infrastructure development in different regions of the world does not follow a symmetrically equal pattern. Because of the importance of infrastructure in the tourism development, the present research is an attempt to examine the hard elements of tourism infrastructure in different provinces of Iran, using the indicators proposed by Pearce and Wu (2015) [Pearce, P. L. & Wu, M. Y. (2015). Soft infrastructure at tourism sites: identifying key issues for Asian tourism from case studies. ...

  20. The efficacy and characteristics of warm-up and re-warm-up practices in soccer players: a systematic review.

    Science.gov (United States)

    Hammami, Amri; Zois, James; Slimani, Maamer; Russel, Mark; Bouhlel, Ezdine

    2018-01-01

    This review aimed 1) to evaluate the current research that examines the efficacy of warm-up (WU) and re-warm-up (RWU) on physical performance; and 2) to highlight the WU and RWU characteristics that optimise subsequent performance in soccer players. A computerized search was performed in the PubMed, ScienceDirect and Google Scholar (from 1995 to December 2015) for English-language, peer-reviewed investigations using the terms "soccer" OR "football" AND "warm-up" OR "stretching" OR "post-activation potentiation" OR "pre-activity" OR "re-warm-up" AND "performance" OR "jump" OR "sprint" OR "running". Twenty seven articles were retrieved. Particularly, 22 articles examined the effects of WU on soccer performance and 5 articles focused on the effects of RWU. Clear evidence exists supporting the inclusion of dynamic stretching or postactivation potentiation-based exercises within a WU as acute performance enhancements were reported (pooled estimate changes of +3.46% and +4.21%, respectively). The FIFA 11+ WU also significantly increases strength, jump, speed and explosive performances (changes from 1% to 20%). At half-time, active RWU protocols including postactivation potentiation practices and multidirectional speed drills attenuate temperature and performance reductions induced by habitual practice. The data obtained in the present review showed that the level of play did not moderate the effectiveness of WU and RWU on soccer performance. This review demonstrated that a static stretching WU reduced acute subsequent performance, while WU activities that include dynamic stretching, PAP-based exercises, and the FIFA 11+ can elicit positive effects in soccer players. The efficacy of an active RWU during half-time is also justified.