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Sample records for working park-fuel cell

  1. WORKING PARK-FUEL CELL COMBINED HEAT AND POWER SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Allan Jones

    2003-09-01

    This report covers the aims and objectives of the project which was to design, install and operate a fuel cell combined heat and power (CHP) system in Woking Park, the first fuel cell CHP system in the United Kingdom. The report also covers the benefits that were expected to accrue from the work in an understanding of the full technology procurement process (including planning, design, installation, operation and maintenance), the economic and environmental performance in comparison with both conventional UK fuel supply and conventional CHP and the commercial viability of fuel cell CHP energy supply in the new deregulated energy markets.

  2. Work productivity in rhinitis using cell phones

    DEFF Research Database (Denmark)

    Bousquet, J.; Bewick, Bridgette M; Arnavielhe, S

    2017-01-01

    Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app (Allergy Diary, Google Play Store and Apple.......83, PP

  3. Working electrode holder and electrochemical cell

    DEFF Research Database (Denmark)

    2016-01-01

    The present disclosure relates to a holder for a test object, more specifically to a holder for measuring electrochemical properties of the test object. One embodiment relates to a working electrode holder for measuring electrochemical properties of a front surface of a test object in a liquid...... in the bottom surface and configured for passage of said liquid, such that liquid is able to pass onto the electrically contacted front surface. The holder may be used in an electrochemical cell....

  4. Controling stem cell proliferation - CKIs at work

    NARCIS (Netherlands)

    Bruggeman, SWM; van Lohuizen, M

    2006-01-01

    The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

  5. Automated platform for designing multiple robot work cells

    Science.gov (United States)

    Osman, N. S.; Rahman, M. A. A.; Rahman, A. A. Abdul; Kamsani, S. H.; Bali Mohamad, B. M.; Mohamad, E.; Zaini, Z. A.; Rahman, M. F. Ab; Mohamad Hatta, M. N. H.

    2017-06-01

    Designing the multiple robot work cells is very knowledge-intensive, intricate, and time-consuming process. This paper elaborates the development process of a computer-aided design program for generating the multiple robot work cells which offer a user-friendly interface. The primary purpose of this work is to provide a fast and easy platform for less cost and human involvement with minimum trial and errors adjustments. The automated platform is constructed based on the variant-shaped configuration concept with its mathematical model. A robot work cell layout, system components, and construction procedure of the automated platform are discussed in this paper where integration of these items will be able to automatically provide the optimum robot work cell design according to the information set by the user. This system is implemented on top of CATIA V5 software and utilises its Part Design, Assembly Design, and Macro tool. The current outcomes of this work provide a basis for future investigation in developing a flexible configuration system for the multiple robot work cells.

  6. Do cell phones affect establishing electronic working length?

    Science.gov (United States)

    Hurstel, Justine; Guivarc'h, Maud; Pommel, Ludovic; Camps, Jean; Tassery, Hervé; Cohen, Stephen; Bukiet, Frédéric

    2015-06-01

    Patients often keep their cell phones on and nearby during root canal therapy. Cell phones release electromagnetic interference, which might disturb electronic working length measurements. The purpose of this ex vivo study was to determine the effect of a cell phone (Apple iPhone 5 [Apple, Cupertino, CA] or KP100 [LG, Seoul, Korea]) placed into direct contact with an electronic apex locator (EAL) (Dentaport Root ZX module [J Morita Corp, Tokyo, Japan] or Propex II [Dentsply Maillefer, Ballaigues, Switzerland]) on working length determination. Twenty-six human premolars without fractures or carious lesions were used; previously cleaned; and observed under magnification (×15) in order to check for the presence of only 1 apical foramen, the absence of apical resorption, an "open" apex, and accessory canals. The working length measurement was performed with a #15 K-file in the presence of 2.6% sodium hypochlorite under 4 conditions: (1) visually, under the microscope until the file tip reached the canal terminus; (2) electronically, without the cell phone in proximity; (3) electronically, with the cell phone in standby mode placed in physical contact with the EAL; and (4) electronically, with the cell phone activated by a call in the same position. The experimental model for electronic working length determination was a screw top plastic container filled with a saline solution. The measurements were repeated 3 times per canal under each condition. Scores of 1 to 3 categorized the stability of the readings as follows: (1) good stability; (2) unstable reading with minor difficulties determining the working length; and (3) major difficulties or impossible to determine the working length. A 2-way repeated measures analysis of variance (way 1: cell phone type and way 2: EAL model) was performed, and a second repeated measures analysis of variance was performed to seek a difference among the 4 working length determination conditions. Neither the cell phone type nor the EAL

  7. Modelling of robotic work cells using agent based-approach

    Science.gov (United States)

    Sękala, A.; Banaś, W.; Gwiazda, A.; Monica, Z.; Kost, G.; Hryniewicz, P.

    2016-08-01

    In the case of modern manufacturing systems the requirements, both according the scope and according characteristics of technical procedures are dynamically changing. This results in production system organization inability to keep up with changes in a market demand. Accordingly, there is a need for new design methods, characterized, on the one hand with a high efficiency and on the other with the adequate level of the generated organizational solutions. One of the tools that could be used for this purpose is the concept of agent systems. These systems are the tools of artificial intelligence. They allow assigning to agents the proper domains of procedures and knowledge so that they represent in a self-organizing system of an agent environment, components of a real system. The agent-based system for modelling robotic work cell should be designed taking into consideration many limitations considered with the characteristic of this production unit. It is possible to distinguish some grouped of structural components that constitute such a system. This confirms the structural complexity of a work cell as a specific production system. So it is necessary to develop agents depicting various aspects of the work cell structure. The main groups of agents that are used to model a robotic work cell should at least include next pattern representatives: machine tool agents, auxiliary equipment agents, robots agents, transport equipment agents, organizational agents as well as data and knowledge bases agents. In this way it is possible to create the holarchy of the agent-based system.

  8. New Designs of Biofuel Cells and Their Work Testing

    Science.gov (United States)

    Stom, D. I.; Zhdanova, G. O.; Kashevskii, A. V.

    2017-11-01

    The developed designs and modifications of biofuel elements (BFC) are presented. The approbation of their work using strains and consortia of microorganisms is given. The proposed designs made it possible to solve a number of problems that arise when working with BFC: 1) gain access to the contents of the anode BFC space without disturbing its sterility and anaerobic environment; 2) take samples from the anode space for chemical and microbiological analysis without interrupting the BFC operation; 3) conduct continuous monitoring of electrochemical processes directly in the anode space (Ox-Red media, electrode charge, concentration of hydrogen and other ions by means of potentiometry).

  9. Organic and perovskite solar cells: Working principles, materials and interfaces.

    Science.gov (United States)

    Marinova, Nevena; Valero, Silvia; Delgado, Juan Luis

    2017-02-15

    In the last decades organic solar cells (OSCs) have been considered as a promising photovoltaic technology with the potential to provide reasonable power conversion efficiencies combined with low cost and easy processability. Unexpectedly, Perovskite Solar Cells (PSCs) have experienced unprecedented rise in Power Conversion Efficiency (PCE) thus emerging as a highly efficient photovoltaic technology. OSCs and PSCs are two different kind of devices with distinct charge generation mechanism, which however share some similarities in the materials processing, thus standard strategies developed for OSCs are currently being employed in PSCs. In this article, we recapitulate the main processes in these two types of photovoltaic technologies with an emphasis on interfacial processes and interfacial modification, spotlighting the materials and newest approaches in the interfacial engineering. We discuss on the relevance of well-known materials coming from the OSCs field, which are now being tested in the PSCs field, while maintaining a focus on the importance of the material design for highly efficient, stable and accessible solar cells. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Power output and carrier dynamics studies of perovskite solar cells under working conditions.

    Science.gov (United States)

    Yu, Man; Wang, Hao-Yi; Hao, Ming-Yang; Qin, Yujun; Fu, Li-Min; Zhang, Jian-Ping; Ai, Xi-Cheng

    2017-08-02

    Perovskite solar cells have emerged as promising photovoltaic systems with superb power conversion efficiency. For the practical application of perovskite devices, the greatest concerns are the power output density and the related dynamics under working conditions. In this study, the working conditions of planar and mesoscopic perovskite solar cells are simulated and the power output density evolutions with the working voltage are highlighted. The planar device exhibits higher capability of outputting power than the mesoscopic one. The transient photoelectric conversion dynamics are investigated under the open circuit, short circuit and working conditions. It is found that the power output and dynamic processes are correlated intrinsically, which suggests that the power output is the competitive result of the charge carrier recombination and transport. The present work offers a unique view to elucidating the relationship between the power output and the charge carrier dynamics for perovskite solar cells in a comprehensive manner, which would be beneficial to their future practical applications.

  11. Virtual reality based support system for layout planning and programming of an industrial robotic work cell.

    Science.gov (United States)

    Yap, Hwa Jen; Taha, Zahari; Dawal, Siti Zawiah Md; Chang, Siow-Wee

    2014-01-01

    Traditional robotic work cell design and programming are considered inefficient and outdated in current industrial and market demands. In this research, virtual reality (VR) technology is used to improve human-robot interface, whereby complicated commands or programming knowledge is not required. The proposed solution, known as VR-based Programming of a Robotic Work Cell (VR-Rocell), consists of two sub-programmes, which are VR-Robotic Work Cell Layout (VR-RoWL) and VR-based Robot Teaching System (VR-RoT). VR-RoWL is developed to assign the layout design for an industrial robotic work cell, whereby VR-RoT is developed to overcome safety issues and lack of trained personnel in robot programming. Simple and user-friendly interfaces are designed for inexperienced users to generate robot commands without damaging the robot or interrupting the production line. The user is able to attempt numerous times to attain an optimum solution. A case study is conducted in the Robotics Laboratory to assemble an electronics casing and it is found that the output models are compatible with commercial software without loss of information. Furthermore, the generated KUKA commands are workable when loaded into a commercial simulator. The operation of the actual robotic work cell shows that the errors may be due to the dynamics of the KUKA robot rather than the accuracy of the generated programme. Therefore, it is concluded that the virtual reality based solution approach can be implemented in an industrial robotic work cell.

  12. The evolutionary origin of somatic cells under the dirty work hypothesis.

    Directory of Open Access Journals (Sweden)

    Heather J Goldsby

    2014-05-01

    Full Text Available Reproductive division of labor is a hallmark of multicellular organisms. However, the evolutionary pressures that give rise to delineated germ and somatic cells remain unclear. Here we propose a hypothesis that the mutagenic consequences associated with performing metabolic work favor such differentiation. We present evidence in support of this hypothesis gathered using a computational form of experimental evolution. Our digital organisms begin each experiment as undifferentiated multicellular individuals, and can evolve computational functions that improve their rate of reproduction. When such functions are associated with moderate mutagenic effects, we observe the evolution of reproductive division of labor within our multicellular organisms. Specifically, a fraction of the cells remove themselves from consideration as propagules for multicellular offspring, while simultaneously performing a disproportionately large amount of mutagenic work, and are thus classified as soma. As a consequence, other cells are able to take on the role of germ, remaining quiescent and thus protecting their genetic information. We analyze the lineages of multicellular organisms that successfully differentiate and discover that they display unforeseen evolutionary trajectories: cells first exhibit developmental patterns that concentrate metabolic work into a subset of germ cells (which we call "pseudo-somatic cells" and later evolve to eliminate the reproductive potential of these cells and thus convert them to actual soma. We also demonstrate that the evolution of somatic cells enables phenotypic strategies that are otherwise not easily accessible to undifferentiated organisms, though expression of these new phenotypic traits typically includes negative side effects such as aging.

  13. Virtual reality based support system for layout planning and programming of an industrial robotic work cell.

    Directory of Open Access Journals (Sweden)

    Hwa Jen Yap

    Full Text Available Traditional robotic work cell design and programming are considered inefficient and outdated in current industrial and market demands. In this research, virtual reality (VR technology is used to improve human-robot interface, whereby complicated commands or programming knowledge is not required. The proposed solution, known as VR-based Programming of a Robotic Work Cell (VR-Rocell, consists of two sub-programmes, which are VR-Robotic Work Cell Layout (VR-RoWL and VR-based Robot Teaching System (VR-RoT. VR-RoWL is developed to assign the layout design for an industrial robotic work cell, whereby VR-RoT is developed to overcome safety issues and lack of trained personnel in robot programming. Simple and user-friendly interfaces are designed for inexperienced users to generate robot commands without damaging the robot or interrupting the production line. The user is able to attempt numerous times to attain an optimum solution. A case study is conducted in the Robotics Laboratory to assemble an electronics casing and it is found that the output models are compatible with commercial software without loss of information. Furthermore, the generated KUKA commands are workable when loaded into a commercial simulator. The operation of the actual robotic work cell shows that the errors may be due to the dynamics of the KUKA robot rather than the accuracy of the generated programme. Therefore, it is concluded that the virtual reality based solution approach can be implemented in an industrial robotic work cell.

  14. Optimization of Ferritic Steel Porous Supports for Protonic Fuel Cells Working at 600°C

    DEFF Research Database (Denmark)

    Molin, Sebastian; Chen, Ming; Bonanos, Nikolaos

    2014-01-01

    oxide fuel cell. In this work corrosion properties of a Fe22Cr0.4Mn alloy in porous form are evaluated in humidified hydrogen at 600°C and a method to improve its corrosion resistance is reported. Supports in the not modified state corrode rapidly by formation of dual phase oxides whereas after...... the modification by preoxidation supports offer high corrosion resistance allowing construction of fuel cells....

  15. An electrochemical cell for the efficient turn around of wafer working electrodes.

    Science.gov (United States)

    Wozniak, Nicholas R; Frey, Alyssa A; Osterbur, Lucas W; Boman, Timothy S; Hampton, Jennifer R

    2010-03-01

    We present a new design for an electrochemical cell for use with wafer working electrodes. The key feature of the design is the use of half turn thumb screws to form a liquid-tight seal between an o-ring and the sample surface. The assembly or disassembly of the cell requires a half turn of each thumb screw, which facilitates the quick turn around of wafer samples. The electrochemical performance of the cell is demonstrated by cyclic voltammetry and double step chronoamperometry measurements of the ferricyanide/ferrocyanide couple.

  16. Development of the work on fuel cells in the Ministry for Atomic Energy of Russian Federation

    Energy Technology Data Exchange (ETDEWEB)

    Lubovin, B.Y.; Novitski, E.Z.

    1996-04-01

    This paper describes research on fuel cells in the Russian Federation. The beginning of the practical work on fuel cells in Russia dates back to the 50`s and 60`s when the Ural Electrochemical Plant and the Ural Electromechanical Plant of the Ministry of Medium Machine-Building of the USSR, all Russian Research Institute of the power sources and many other institutes of the Ministry of Electrotechnical Industry of the USSR got to the development of the alkaline fuel cells for the spaceships according to the tasks of the SPC `Energy` and for the submarines on the tasks of the Ministry of Defense.

  17. An electrochemical cell for the efficient turn around of wafer working electrodes

    Science.gov (United States)

    Wozniak, Nicholas R.; Frey, Alyssa A.; Osterbur, Lucas W.; Boman, Timothy S.; Hampton, Jennifer R.

    2010-03-01

    We present a new design for an electrochemical cell for use with wafer working electrodes. The key feature of the design is the use of half turn thumb screws to form a liquid-tight seal between an o-ring and the sample surface. The assembly or disassembly of the cell requires a half turn of each thumb screw, which facilitates the quick turn around of wafer samples. The electrochemical performance of the cell is demonstrated by cyclic voltammetry and double step chronoamperometry measurements of the ferricyanide/ferrocyanide couple.

  18. High work function transparent middle electrode for organic tandem solar cells

    NARCIS (Netherlands)

    Moet, D. J. D.; de Bruyn, P.; Blom, P. W. M.

    2010-01-01

    The use of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) in combination with ZnO as middle electrode in solution-processed organic tandem solar cells requires a pH modification of the PEDOT:PSS dispersion. We demonstrate that this neutralization leads to a reduced work function

  19. Work productivity in rhinitis using cell phones: The MASK pilot study

    NARCIS (Netherlands)

    Bousquet, J.; Bewick, M.; Arnavielhe, S.; Mathieu-Dupas, E.; Murray, R.; Bedbrook, A.; Caimmi, D. P.; Vandenplas, O.; Hellings, P. W.; Bachert, C.; Anto, J. M.; Bergmann, K. C.; Bindslev-Jensen, C.; Bosnic-Anticevich, S.; Bouchard, J.; Canonica, G. W.; Chavannes, N. H.; Cruz, A. A.; Dahl, R.; Demoly, P.; de Vries, G.; Devillier, P.; Fink-Wagner, A.; Fokkens, W. J.; Fonseca, J.; Guldemond, N. A.; Haahtela, T.; Hellqvist-Dahl, B.; Just, J.; Keil, T.; Klimek, L.; Kowalski, M. L.; Kuna, P.; Kvedariene, V.; Laune, D.; Larenas-Linnemann, D.; Mullol, J.; Pereira, A. M.; Carreiro-Martins, P.; Melén, E.; Morais-Almeida, M.; Nogueira-Silva, L.; O'Hehir, R. E.; Papadopoulos, N. G.; Passalacqua, G.; Portejoie, F.; Price, D.; Ryan, D.; Samolinski, B.; Sheikh, A.; Simons, F. E. R.; Spranger, O.; Todo Bom, A.; Tomazic, P. V.; Triggiani, M.; Valero, A.; Valovirta, E.; Valiulis, A.; van Eerd, M.; Wickman, M.; Young, I.; Zuberbier, T.

    2017-01-01

    Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app (Allergy Diary, Google Play Store and Apple App

  20. Fuel cell technology for classroom instruction. Basic principles, experiments, work sheets. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Voigt, Cornelia; Hoeller, Stefan; Kueter, Uwe

    2009-07-01

    This book provides a clear introduction and overview to fuel cell technology and its associated subject areas. Examples of experiments using solar cells, electrolysis and fuel cells convey the knowledge for forthcoming tests in an understandable manner. The preparation of classroom experiments is made considerably easier for the teacher thanks to the experiment work sheets. These contain the necessary information concerning the material, set-up and execution of the experiment, and questions for evaluation purposes. Online-Shop The training documents and student work sheets combine the basic knowledge, questions and answers, and are ideal for copying. A comprehensive glossary at the end of the book explains all the important technical terms. (orig.)

  1. Effect of Structure, Temperature, and Metal Work Function on Performance of Organometallic Perovskite Solar Cells

    Science.gov (United States)

    Hossain, M. I.; Aïssa, B.

    2017-03-01

    The impact of hole transport materials (HTMs) on the performance of methylammonium lead halide (CH3NH3PbI3)-based perovskite solar cells has been investigated using computational analysis. The main objective is to replace the HTM with the aim of enhancing the lifetime and decreasing the overall cost of the device. As the CH3NH3PbI3 absorber layer shows an absorption coefficient as high as 105/cm, all photons with incident energy larger the material bandgap are absorbed within only a 400-nm-thick layer. Also, all the electronic and optical properties of such an absorber layer are suitable for use in photovoltaic (PV) devices. Hence, the effects of the HTM thickness, operating temperature, incident light spectrum, and metal electrode work function on the charge collection were studied numerically. For a cell with Cu2O as HTM, efficiency exceeding 25% is predicted for a 350-nm-thick absorber layer. Also, a fully optimized device architecture without HTM shows the possibility of fabricating a perovskite solar cell with PV efficiency exceeding 15%. We expect considerable minimization of the energy loss in this structure due to charge transfer across the heterojunction. Moreover, the effect of temperature on perovskite solar cells and potential electrodes with different work functions has been investigated. Our results are believed to help open an experimental avenue to achieve optimum results for perovskite solar cells with various structures.

  2. Data sharing in stem cell translational science: policy statement by the International Stem Cell Forum Ethics Working Party.

    Science.gov (United States)

    Bredenoord, Annelien L; Mostert, Menno; Isasi, Rosario; Knoppers, Bartha M

    2015-01-01

    Data and sample sharing constitute a scientific and ethical imperative but need to be conducted in a responsible manner in order to protect individual interests as well as maintain public trust. In 2014, the Global Alliance for Genomics and Health (GA4GH) adopted a common Framework for Responsible Sharing of Genomic and Health-Related Data. The GA4GH Framework is applicable to data sharing in the stem cell field, however, interpretation is required so as to provide guidance for this specific context. In this paper, the International Stem Cell Forum Ethics Working Party discusses those principles that are specific to translational stem cell science, including engagement, data quality and safety, privacy, security and confidentiality, risk-benefit analysis and sustainability.

  3. Working memory cells' behavior may be explained by cross-regional networks with synaptic facilitation.

    Directory of Open Access Journals (Sweden)

    Sergio Verduzco-Flores

    2009-08-01

    Full Text Available Neurons in the cortex exhibit a number of patterns that correlate with working memory. Specifically, averaged across trials of working memory tasks, neurons exhibit different firing rate patterns during the delay of those tasks. These patterns include: 1 persistent fixed-frequency elevated rates above baseline, 2 elevated rates that decay throughout the tasks memory period, 3 rates that accelerate throughout the delay, and 4 patterns of inhibited firing (below baseline analogous to each of the preceding excitatory patterns. Persistent elevated rate patterns are believed to be the neural correlate of working memory retention and preparation for execution of behavioral/motor responses as required in working memory tasks. Models have proposed that such activity corresponds to stable attractors in cortical neural networks with fixed synaptic weights. However, the variability in patterned behavior and the firing statistics of real neurons across the entire range of those behaviors across and within trials of working memory tasks are typical not reproduced. Here we examine the effect of dynamic synapses and network architectures with multiple cortical areas on the states and dynamics of working memory networks. The analysis indicates that the multiple pattern types exhibited by cells in working memory networks are inherent in networks with dynamic synapses, and that the variability and firing statistics in such networks with distributed architectures agree with that observed in the cortex.

  4. Unified Quantum Model of Work Generation in Thermoelectric Generators, Solar and Fuel Cells

    Directory of Open Access Journals (Sweden)

    Robert Alicki

    2016-05-01

    Full Text Available In the previous papers, the idea of “hidden oscillations” has been applied to explain work generation in semiconductor photovoltaic cells and thermoelectric generators. The aim of this paper is firstly to extend this approach to fuel cells and, secondly, to create a unified quantum model for all types of such devices. They are treated as electron pumps powered by heat or chemical engines. The working fluid is electron gas and the necessary oscillating element (“piston” is provided by plasma oscillation. Those oscillations are localized around the junction that also serves as a diode rectifying fast electric charge oscillations and yielding a final output direct current (DC. The dynamics of the devices are governed by the Markovian master equations that can be derived in a rigorous way from the underlying Hamiltonian models and are consistent with the laws of thermodynamics. The new ingredient is the derivation of master equations for systems driven by chemical reactions.

  5. Ergonomic Optimization of a Manufacturing System Work Cell in a Virtual Environment

    Directory of Open Access Journals (Sweden)

    F. Caputo

    2006-01-01

    Full Text Available The paper deals with the development of a methodology for studying, in a virtual environment, the ergonomics of a work cell in an automotive manufacturing system. The methodology is based on the use of digital human models and virtual reality techniques in order to simulate, in a virtual environment, human performances during the execution of assembly operations. The objective is to define the optimum combination of those geometry features that influence human postures during assembly operation in a work cell. In the demanding global marketplace, ensuring that human factors are comprehensively addressed is becoming an increasingly important aspect of design. Manufacturers have to design work cells that conform to all relevant Health and Safety standards. The proposed methodology can assist the designer to evaluate the performance of workers in a workplace before it has been realized. The paper presents an analysis of a case study proposed by COMAU, a global supplier of industrial automation systems for the automotive manufacturing sector and a global provider of full maintenance services. The study and all the virtual simulations have been carried out in the Virtual Reality Laboratory of the Competence Regional Center for the qualification of transportation systems (CRdC “Trasporti” - www.centrodicompetenzatrasporti.unina. it, which was founded by the Campania region with the aim of delivering advanced services and introducing new technologies into local companies operating in the field of transport. 

  6. The Temperature Effect on the Working Characteristics of Solar Cells Based on Organometal Halide Perovskite Crystals

    Science.gov (United States)

    Dewinggih, Tanti; Shobih; Muliani, Lia; Herman; Hidayat, Rahmat

    2017-07-01

    Organometal halide perovskites have been much studied as an active material in a new generation of solar cell with high power conversion efficiency. The chemical reactions involved in their crystallization process are simple but the crystallization process and the formed crystal are very sensitive to temperature and humidity. In general, if the electronic structure of this active material is easily affected by temperature, the working performance of its solar cell will be also easily affected by temperature. In this work, we investigated the temperature effect on the working performance, namely the J-V characteristics, of CH3NH3PbI3 perovskite based solar cell. The measurement result show that the J-V characteristic significantly changed with temperature. The J-V curve shows a diode characteristic at room temperature but it changes to an Ohmic characteristic at high temperature. This characteristics change may be due to the degradation of the perovskite crystals, which may be caused by separation and recrystallization PbI2 inside the perovskite layer.

  7. Work productivity in rhinitis using cell phones: The MASK pilot study.

    Science.gov (United States)

    Bousquet, J; Bewick, M; Arnavielhe, S; Mathieu-Dupas, E; Murray, R; Bedbrook, A; Caimmi, D P; Vandenplas, O; Hellings, P W; Bachert, C; Anto, J M; Bergmann, K C; Bindslev-Jensen, C; Bosnic-Anticevich, S; Bouchard, J; Canonica, G W; Chavannes, N H; Cruz, A A; Dahl, R; Demoly, P; De Vries, G; Devillier, P; Fink-Wagner, A; Fokkens, W J; Fonseca, J; Guldemond, N A; Haahtela, T; Hellqvist-Dahl, B; Just, J; Keil, T; Klimek, L; Kowalski, M L; Kuna, P; Kvedariene, V; Laune, D; Larenas-Linnemann, D; Mullol, J; Pereira, A M; Carreiro-Martins, P; Melén, E; Morais-Almeida, M; Nogueira-Silva, L; O'Hehir, R E; Papadopoulos, N G; Passalacqua, G; Portejoie, F; Price, D; Ryan, D; Samolinski, B; Sheikh, A; Simons, F E R; Spranger, O; Todo Bom, A; Tomazic, P V; Triggiani, M; Valero, A; Valovirta, E; Valiulis, A; van Eerd, M; Wickman, M; Young, I; Zuberbier, T

    2017-10-01

    Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale (VAS). A mobile phone app (Allergy Diary, Google Play Store and Apple App Store) collects data from daily visual analogue scales (VAS) for overall allergic symptoms (VAS-global measured), nasal (VAS-nasal), ocular (VAS-ocular) and asthma symptoms (VAS-asthma) as well as work (VAS-work). A combined nasal-ocular score is calculated. The Allergy Diary is available in 21 countries. The app includes the Work Productivity and Activity Impairment Allergic Specific Questionnaire (WPAI:AS) in six EU countries. All consecutive users who completed the VAS-work from 1 June to 31 October 2016 were included in the study. A total of 1136 users filled in 5818 days of VAS-work. Symptoms of allergic rhinitis were controlled (VAS-global 50). There was a significant correlation between VAS-global calculated and VAS-work (Rho=0.83, P<0.00001, Spearman's rank test). In 144 users, there was a significant correlation between VAS-work and WPAI:AS (Rho=0.53, P<0.0001). This pilot study provides not only proof-of-concept data on the work impairment collected with the app but also data on the app itself, especially the distribution of responses for the VAS. This supports the interpretation that persons with rhinitis report both the presence and the absence of symptoms. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

  8. Transfer printing methods for flexible thin film solar cells: basic concepts and working principles.

    Science.gov (United States)

    Lee, Chi Hwan; Kim, Dong Rip; Zheng, Xiaolin

    2014-09-23

    Fabricating thin film solar cells (TFSCs) on flexible substrates will not only broaden the applications of solar cells, but also potentially reduce the installation cost. However, a critical challenge for fabricating flexible TFSCs on flexible substrates is the incompatibility issues between the thermal, mechanical, and chemical properties of these substrates and the fabrication conditions. Transfer printing methods, which use conventional substrates for the fabrication and then deliver the TFSCs onto flexible substrates, play a key role to overcome these challenges. In this review, we discuss the basic concepts and working principles of four major transfer printing methods associated with (1) transfer by sacrificial layers, (2) transfer by porous Si layer, (3) transfer by controlled crack, and (4) transfer by water-assisted thin film delamination. We also discuss the challenges and opportunities for implementing these methods for practical solar cell manufacture.

  9. Fabrication of working and counter electrodes on plastic substrates for flexible dye-sensitized solar cells

    Directory of Open Access Journals (Sweden)

    Lai Yeong-Lin

    2017-01-01

    Full Text Available This paper presents the fabrication technologies related to flexible titanium-dioxide (TiO2 working electrodes and graphite counter electrodes on plastic substrates for dye-sensitized solar cells (DSSCs. The DSSC on a plastic substrate had a sandwich structure consisting of a TiO2 working electrode, an electrolyte, and a graphite counter electrode. Nano-crystalline TiO2 powder, titanium (IV bis (ammonium lactato dihydroxide (TALH, de-ionized water (DI water, and Triton X-100 were added to the mixture of PDMS base and curing agents to form TiO2 colloids for the TiO2 working electrode. The material analysis of the TiO2 working electrode and the graphite counter electrode employed field-emission scanning electron microscopy (FE-SEM, atomic force microscopy (AFM, and X-ray diffraction (XRD. Nano-crystalline TiO2 powder was used to form the TiO2 working electrode. The surface characteristics of the TiO2 and graphite films were investigated herein. The low-cost fabrication technologies of the TiO2 working electrode and graphite counter electrode on the plastic substrate were clearly demonstrated.

  10. The Impact of Sex Work Interruption on Blood-Derived T Cells in Sex Workers from Nairobi, Kenya.

    Science.gov (United States)

    Omollo, Kenneth; Boily-Larouche, Geneviève; Lajoie, Julie; Kimani, Makobu; Cheruiyot, Julianna; Kimani, Joshua; Oyugi, Julius; Fowke, Keith Raymond

    Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead to recruitment of activated T cells to the FGT, thereby increasing risk of HIV infection. The purpose of this study was to evaluate the impact of sex work on activation and memory phenotypes of peripheral T cells among female sex workers (FSW) from Nairobi, Kenya. Thirty FSW were recruited from the Pumwani Sex Workers Cohort, 10 in each of the following groups: HIV-exposed seronegative (at least 7 years in active sex work), HIV positive, and New Negative (HIV negative, less than 3 years in active sex work). Blood was obtained at three different phases (active sex work, abstinence from sex work-sex break, and following resumption of sex work). Peripheral blood mononuclear cells were isolated and stained for phenotypic markers (CD3, CD4, CD8, and CD161), memory phenotype markers (CD45RA and CCR7), activation markers (CD69, HLA-DR, and CD95), and the HIV coreceptor (CCR5). T-cell populations were compared between groups. In HIV-positive women, CD8+CCR5+ T cells declined at the sex break period, while CD4+CD161+ T cells increased when returning to sex work. All groups showed no significant changes in systemic T-cell activation markers following the interruption of sex work, however, significant reductions in naive CD8+ T cells were noted. For each of the study points, HIV positives had higher effector memory and CD8+CD95+ T cells and lower naive CD8+ T cells than the HIV-uninfected groups. Interruption of sex work had subtle effects on systemic T-cell memory phenotypes.

  11. Associative memory cells and their working principle in the brain [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Jin-Hui Wang

    2018-01-01

    Full Text Available The acquisition, integration and storage of exogenous associated signals are termed as associative learning and memory. The consequences and processes of associative thinking and logical reasoning based on these stored exogenous signals can be memorized as endogenous signals, which are essential for decision making, intention, and planning. Associative memory cells recruited in these primary and secondary associative memories are presumably the foundation for the brain to fulfill cognition events and emotional reactions in life, though the plasticity of synaptic connectivity and neuronal activity has been believed to be involved in learning and memory. Current reports indicate that associative memory cells are recruited by their mutual synapse innervations among co-activated brain regions to fulfill the integration, storage and retrieval of associated signals. The activation of these associative memory cells initiates information recall in the mind, and the successful activation of their downstream neurons endorses memory presentations through behaviors and emotion reactions. In this review, we aim to draw a comprehensive diagram for associative memory cells, working principle and modulation, as well as propose their roles in cognition, emotion and behaviors.

  12. Optimization of Ferritic Steel Porous Supports for Protonic Fuel Cells Working at 600°C

    DEFF Research Database (Denmark)

    Venkatachalam, Vinothini; Molin, Sebastian; Chen, Ming

    2014-01-01

    , and is particularly helpful for a porous metal supported cell because it limits the corrosion of the metal by exposure to water vapor in the anode gas. In this work, we show the effect of composition and microstructure on the high temperature corrosion and phase stability (formation of sigma phase/Laves phase......) of porous alloys. Alloys in the compositional range Fe-20%Cr to Fe-32%Cr were evaluated and the effects of surface modification on corrosion resistance were studied using thermogravimetry, x-ray diffractometry and electron microscopy. The results show that surface modified porous ferritic steels are very...

  13. The effect of shift work on red blood cell distribution width.

    Science.gov (United States)

    Loprinzi, Paul D

    2015-04-01

    Limited research demonstrates that shift work (e.g., evening shift, night shift, rotating shift) increases the risk of certain health outcomes, such as hypertriglyceridemia and metabolic syndrome. Red blood cell distribution width (RDW), which is commonly assessed and reported by physicians, is a novel biomarker of cardiovascular disease. However, no study has examined the association of shift work on RDW, which was the purpose of this study. Data from the 2005-2010 NHANES were used. RDW was assessed from a blood sample; shift work was assessed from a questionnaire, and various demographic, behavioral/psychological, occupational, and biological parameters were included as covariates. The fully adjusted model showed that the odds of having an elevated RDW for women on rotating shift vs. day shift increased by 46% (OR=1.46; 95% CI: 1.03-2.08). Women on a rotating shift had increased odds of having an elevated RDW, which is concerning as elevated RDW increases the risk of cardiovascular disease and mortality. Health care professionals are encouraged to include questions about organization of work schedules and their tolerance of such schedules during the patient's consultation. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Burnout, Moral Distress, Work-Life Balance, and Career Satisfaction among Hematopoietic Cell Transplantation Professionals.

    Science.gov (United States)

    Neumann, Joyce L; Mau, Lih-Wen; Virani, Sanya; Denzen, Ellen M; Boyle, Deborah A; Boyle, Nancy J; Dabney, Jane; De KeselLofthus, Alexandra; Kalbacker, Marion; Khan, Tippu; Majhail, Navneet S; Murphy, Elizabeth A; Paplham, Pamela; Parran, Leslie; Perales, Miguel-Angel; Rockwood, Todd H; Schmit-Pokorny, Kim; Shanafelt, Tait D; Stenstrup, Elaine; Wood, William A; Burns, Linda J

    2017-12-02

    A projected shortage of hematopoietic cell transplantation (HCT) health professionals was identified as a major issue during the National Marrow Donor Program/Be The Match System Capacity Initiative. Work-related distress and work-life balance were noted to be potential barriers to recruitment/retention. This study examined these barriers and their association with career satisfaction across HCT disciplines. A cross-sectional, 90-item, web-based survey was administered to advanced practice providers, nurses, physicians, pharmacists, and social workers in 2015. Participants were recruited from membership lists of 6 professional groups. Burnout (measured with the Maslach Burnout Inventory subscales of emotional exhaustion and depersonalization) and moral distress (measured by Moral Distress Scale-Revised) were examined to identify work-related distress. Additional questions addressed demographics, work-life balance, and career satisfaction. Of 5759 HCT providers who received an individualized invitation to participate, 914 (16%) responded; 627 additional participants responded to an open link survey. Significant differences in demographic and practice characteristics existed across disciplines (P burnout differed across disciplines (P burnout, whereas social workers had the lowest prevalence at less than one-third. Moral distress scores ranged from 0 to 336 and varied by discipline (P burnout varied by discipline; however, moral distress was a significant contributing factor for all providers. Those with burnout were more likely to report inadequate work-life balance and a low level of career satisfaction; however, overall there was a high level of career satisfaction across disciplines. Burnout, moral distress, and inadequate work-life balance existed at a variable rate in all HCT disciplines, yet career satisfaction was high. These results suggest specific areas to address in the work environment for HCT health professionals, especially the need for relief of

  15. Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus

    Directory of Open Access Journals (Sweden)

    Apiwat Sirichoat

    2015-10-01

    Full Text Available Asiatic acid is a pentacyclic triterpene from Centella asiatica. Previous studies have reported that asiatic acid exhibits antioxidant and neuroprotective activities in cell culture. It also prevents memory deficits in animal models. The objective of this study was to investigate the relationship between spatial working memory and changes in cell proliferation within the hippocampus after administration of asiatic acid to male Spraque-Dawley rats. Control rats received vehicle (propylene glycol while treated rats received asiatic acid (30 mg/kg orally for 14 or 28 days. Spatial memory was determined using the novel object location (NOL test. In animals administered asiatic acid for both 14 and 28 days, the number of Ki-67 positive cells in the subgranular zone of the dentate gyrus was significantly higher than in control animals. This was associated with a significant increase in their ability to discriminate between novel and familiar object locations in a novel object discrimination task, a hippocampus-dependent spatial memory test. Administration of asiatic acid also significantly increased doublecortin (DCX and Notch1 protein levels in the hippocampus. These findings demonstrate that asiatic acid treatment may be a potent cognitive enhancer which improves hippocampal-dependent spatial memory, likely by increasing hippocampal neurogenesis.

  16. Polystyrene-block-Poly(ionic liquid) Copolymers as Work Function Modifiers in Inverted Organic Photovoltaic Cells.

    Science.gov (United States)

    Park, Jong Baek; Isik, Mehmet; Park, Hea Jung; Jung, In Hwan; Mecerreyes, David; Hwang, Do-Hoon

    2018-02-07

    Interfacial layers play a critical role in building up the Ohmic contact between electrodes and functional layers in organic photovoltaic (OPV) solar cells. These layers are based on either inorganic oxides (ZnO and TiO 2 ) or water-soluble organic polymers such as poly[(9,9-dioctyl-2,7-fluorene)-alt-(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)] and polyethylenimine ethoxylated (PEIE). In this work, we have developed a series of novel poly(ionic liquid) nonconjugated block copolymers for improving the performance of inverted OPV cells by using them as work function modifiers of the indium tin oxide (ITO) cathode. Four nonconjugated polyelectrolytes (n-CPEs) based on polystyrene and imidazolium poly(ionic liquid) (PSImCl) were synthesized by reversible addition-fragmentation chain transfer polymerization. The ratio of hydrophobic/hydrophilic block copolymers was varied depending on the ratio of polystyrene to the PSImCl block. The ionic density, which controls the work function of the electrode by forming an interfacial dipole between the electrode and the block copolymers, was easily tuned by simply changing the PSImCl molar ratio. The inverted OPV device with the ITO/PS 29 -b-PSImCl 60 cathode achieved the best power conversion efficiency (PCE) of 7.55% among the synthesized block copolymers, exhibiting an even higher PCE than that of the reference OPV device with PEIE (7.30%). Furthermore, the surface properties of the block copolymers films were investigated by contact angle measurements to explore the influence of the controlled hydrophobic/hydrophilic characters on the device performances.

  17. Working Memory in Children With Neurocognitive Effects From Sickle Cell Disease: Contributions of the Central Executive and Processing Speed.

    Science.gov (United States)

    Smith, Kelsey E; Schatz, Jeffrey

    2016-01-01

    Children with sickle cell disease (SCD) are at risk for working memory deficits due to multiple disease processes. We assessed working memory abilities and related functions in 32 school-age children with SCD and 85 matched comparison children using Baddeley's working memory model as a framework. Children with SCD performed worse than controls for working memory, central executive function, and processing/rehearsal speed. Central executive function was found to mediate the relationship between SCD status and working memory, but processing speed did not. Cognitive remediation strategies that focus on central executive processes may be important for remediating working memory deficits in SCD.

  18. Return to work for patients with diffuse large B-cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation

    DEFF Research Database (Denmark)

    Arboe, Bente; Olsen, Maja Halgren; Goerloev, Jette Soenderskov

    2017-01-01

    BACKGROUND: Autologous stem cell transplantation (ASCT) is the standard treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL) or transformed indolent lymphoma (TIL). The treatment is mainly considered for younger patients still available for the work market. In this study...

  19. Boron-Doped Graphite for High Work Function Carbon Electrode in Printable Hole-Conductor-Free Mesoscopic Perovskite Solar Cells.

    Science.gov (United States)

    Duan, Miao; Tian, Chengbo; Hu, Yue; Mei, Anyi; Rong, Yaoguang; Xiong, Yuli; Xu, Mi; Sheng, Yusong; Jiang, Pei; Hou, Xiaomeng; Zhu, Xiaotong; Qin, Fei; Han, Hongwei

    2017-09-20

    Work function of carbon electrodes is critical in obtaining high open-circuit voltage as well as high device performance for carbon-based perovskite solar cells. Herein, we propose a novel strategy to upshift work function of carbon electrode by incorporating boron atom into graphite lattice and employ it in printable hole-conductor-free mesoscopic perovskite solar cells. The high-work-function boron-doped carbon electrode facilitates hole extraction from perovskite as verified by photoluminescence. Meanwhile, the carbon electrode is endowed with an improved conductivity because of a higher graphitization carbon of boron-doped graphite. These advantages of the boron-doped carbon electrode result in a low charge transfer resistance at carbon/perovskite interface and an extended carrier recombination lifetime. Together with the merit of both high work function and conductivity, the power conversion efficiency of hole-conductor-free mesoscopic perovskite solar cells is increased from 12.4% for the pristine graphite electrode-based cells to 13.6% for the boron-doped graphite electrode-based cells with an enhanced open-circuit voltage and fill factor.

  20. Monoclonal B-cell lymphocytosis: Recommendations from the Dutch Working Group on CLL for daily practice

    NARCIS (Netherlands)

    te Raa, G. D.; van Oers, M. H.; Kater, A. P.

    2012-01-01

    Monoclonal B-cell lymphocytosis (MBL) is defined by the presence of small B-cell clones in asymptomatic individuals. Usually, MBL cells are characterised by a chronic lymphocytic leukaemia (CLL) phenotype ('CLL phenotype MBL'); however, an atypical phenotype ('atypical-CLL phenotype MBL') or

  1. Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex.

    Science.gov (United States)

    Pulungan, Zulhaini Sartika A; Sofro, Zaenal Muttaqien; Partadiredja, Ginus

    2018-01-01

    Fluoride is a chemical compound known to bring about fluorosis. It is thought to disrupt the central nervous system because of its ability to induce excitotoxicity and oxidative stress. Any damage of pyramidal cells in the prefrontal cortex would result in cognitive function and working memory regulation disorders. The present study aimed at investigating the effects of sodium fluoride (NaF) on the working memory and estimated total number of medial prefrontal cortex pyramidal cells of adult male rats. Thirty-two male Wistar rats were assigned into four groups, namely control and three treated groups receiving 5, 10 and 20 mg/kg BW, respectively, of oral NaF solution for 30 days. The working memory test was carried out using a Y-maze. The number of pyramidal cells in the medial prefrontal cortex was estimated using an unbiased stereological method. There was no significant difference among groups in the working memory and number of pyramidal neurons in the medial prefrontal cortex cells.

  2. Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop.

    Science.gov (United States)

    Graham, Christopher F; Solter, Davor; Gearhart, John D; Nadeau, Joseph H; Knowles, Barbara B

    2016-01-01

    In 2016, a symposium was convened in Leroy C. Stevens' honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leadership of Peter Andrews, who have worked together to characterize a significant number of human pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in vivo. Those at the ISCI meeting puzzled through one of the thorniest problems in the therapeutic use of the differentiated derivatives of pluripotent stem cells for human therapy; namely, pluripotent stem cells can differentiate into any cell type in the adult organism, but they also have the capacity for unlimited self-renewal, hence if mutated they may have tumorigenic potential. The meeting considered how these cells might become genetically or epigenetically abnormal and how the safety of these cells for human therapeutic uses could be assessed and assured. The symposium was an opportunity to pay tribute to Leroy Stevens and to the basic science origins of this newest aspect of regenerative medicine. It was a time to reflect on the past and on how it can influence the future of our field.

  3. A Group Counseling Approach for Persons Who Work With Sickle Cell Anemia Clients.

    Science.gov (United States)

    Calvin, Richmond

    Although many workshops on sickle cell anemia have been held, it is still difficult to implement a comprehensive training program for sickle cell anemia clients in many communities. Research data on the topic are somewhat nebulous and insufficient political and social pressure have been exerted to change attitudes and take action towards the…

  4. The SCD - Stem Cell Differentiation ESA project: preparatory work for the spaceflight mission

    NARCIS (Netherlands)

    Versari, S.; Barenghi, L.; van Loon, J.; Bradamante, S.

    2016-01-01

    Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mesenchymal stem cells (BMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been

  5. Investigation of metal-gate work-function variability in FinFET structures and implications for SRAM cell design

    Science.gov (United States)

    Rathore, Rituraj Singh; Rana, Ashwani K.

    2017-10-01

    In sub-20 nm CMOS technology nodes, the parameter variability has become a main hurdle during the scaling of devices. Recently, the use of metal gate stacks in nano-scale FinFET structure has a significant impact on the intrinsic parameter fluctuations due to the granular nature of metals. A 14 nm FinFET structure has been considered to study the impact of metal-gate work-function variability by using the 3-D device and mixed mode circuit simulation. The present work investigates the impact of work function variability (WFV) on electrical characteristics of various possible FinFET architectures followed by the regression model. Further, the investigation has been extended to study the stability performance of 6-T SRAM cell under the influence of WFV. It is observed that work function variation may result in considerable performance degradation in device as well as SRAM operation in nano domain.

  6. Fermi Potential across Working Solid Oxide Cells with Zirconia or Ceria Electrolytes

    DEFF Research Database (Denmark)

    Jacobsen, Torben; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2014-01-01

    Two kinds of electrochemical relevant potentials are important in order to describe several observed phenomena in operating electrochemical cells with solid electrolytes. This paper gives illustrative examples of how the profiles of the two potential types, the Galvani potential, φ, and the elect...... stabilized zirconia (YSZ) electrolytes. The nature of the two potential types and the importance of each of them for the cell operation are explained....

  7. Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Jiri Ruzicka

    2016-01-01

    Full Text Available The transplantation of stem cells may have a therapeutic effect on the pathogenesis and progression of neurodegenerative disorders. In the present study, we transplanted human mesenchymal stem cells (MSCs into the lateral ventricle of a triple transgenic mouse model of Alzheimer´s disease (3xTg-AD at the age of eight months. We evaluated spatial reference and working memory after MSC treatment and the possible underlying mechanisms, such as the influence of transplanted MSCs on neurogenesis in the subventricular zone (SVZ and the expression levels of a 56 kDa oligomer of amyloid β (Aβ*56, glutamine synthetase (GS and glutamate transporters (Glutamate aspartate transporter (GLAST and Glutamate transporter-1 (GLT-1 in the entorhinal and prefrontal cortices and the hippocampus. At 14 months of age we observed the preservation of working memory in MSC-treated 3xTg-AD mice, suggesting that such preservation might be due to the protective effect of MSCs on GS levels and the considerable downregulation of Aβ*56 levels in the entorhinal cortex. These changes were observed six months after transplantation, accompanied by clusters of proliferating cells in the SVZ. Since the grafted cells did not survive for the whole experimental period, it is likely that the observed effects could have been transiently more pronounced at earlier time points than at six months after cell application.

  8. Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer's Disease.

    Science.gov (United States)

    Ruzicka, Jiri; Kulijewicz-Nawrot, Magdalena; Rodrigez-Arellano, Jose Julio; Jendelova, Pavla; Sykova, Eva

    2016-01-25

    The transplantation of stem cells may have a therapeutic effect on the pathogenesis and progression of neurodegenerative disorders. In the present study, we transplanted human mesenchymal stem cells (MSCs) into the lateral ventricle of a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) at the age of eight months. We evaluated spatial reference and working memory after MSC treatment and the possible underlying mechanisms, such as the influence of transplanted MSCs on neurogenesis in the subventricular zone (SVZ) and the expression levels of a 56 kDa oligomer of amyloid β (Aβ*56), glutamine synthetase (GS) and glutamate transporters (Glutamate aspartate transporter (GLAST) and Glutamate transporter-1 (GLT-1)) in the entorhinal and prefrontal cortices and the hippocampus. At 14 months of age we observed the preservation of working memory in MSC-treated 3xTg-AD mice, suggesting that such preservation might be due to the protective effect of MSCs on GS levels and the considerable downregulation of Aβ*56 levels in the entorhinal cortex. These changes were observed six months after transplantation, accompanied by clusters of proliferating cells in the SVZ. Since the grafted cells did not survive for the whole experimental period, it is likely that the observed effects could have been transiently more pronounced at earlier time points than at six months after cell application.

  9. On the possibility of the in-cell molecular motors working as cargo moorings only

    CERN Document Server

    Lisowski, Bartosz

    2012-01-01

    Although active transport is considered the most efficient way of depositing materials in the appropriate compartments within living cells, free diffusion remains the energetically cheapest and most widespread determinant of the in-cell dynamics. Here we investigate the hypothesis of cargoes - vesicles or organelles - being transported by the means of free diffusion, limited spatially by the molecular motors. Routinely navigating through ever-changing and unsteady environment, utilizing chemical energy (e.g. from hydrolyzing ATP), as the result they transport cell's crucial components, such as neurotransmitters and organelles. In our model the motor, which we identify with kinesin-1 walking along the microtubule, tethers the cargo in the same manner as a mooring rope attached to a bollard holds a ship from drifting toward the open sea. We study the model behavior in the context of optical trap single molecule experiments, mimicking their procedures in our simulations and investigate how the mechanical propert...

  10. US DOE-EM On-Site Disposal Cell Working Group - Fostering Communication On Performance Assessment Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger R. [Savannah River Site (SRS), Aiken, SC (United States); Suttora, Linda C. [U.S. Department of Energy, Office of Site Restoration, Germantown, MD (United States); Phifer, Mark [Savannah River Site (SRS), Aiken, SC (United States)

    2014-03-01

    On-site disposal cells are in use and being considered at several U.S. Department of Energy (USDOE) sites as the final disposition for large amounts of waste associated with cleanup of contaminated areas and facilities. These facilities are typically developed with regulatory oversight from States and/or the US Environmental Protection Agency (USEPA) in addition to USDOE. The facilities are developed to meet design standards for disposal of hazardous waste as well as the USDOE performance based standards for disposal of radioactive waste. The involvement of multiple and different regulators for facilities across separate sites has resulted in some differences in expectations for performance assessments and risk assessments (PA/RA) that are developed for the disposal facilities. The USDOE-EM Office of Site Restoration formed a working group to foster improved communication and sharing of information for personnel associated with these Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) disposal cells and work towards more consistent assumptions, as appropriate, for technical and policy considerations related to performance and risk assessments in support of a Record of Decision and Disposal Authorization Statement. The working group holds teleconferences, as needed, focusing on specific topics of interest. The topics addressed to date include an assessment of the assumptions used for performance assessments and risk assessments (PA/RAs) for on-site disposal cells, requirements and assumptions related to assessment of inadvertent intrusion, DOE Manual 435.1-1 requirements, and approaches for consideration of the long-term performance of liners and covers in the context of PAs. The working group has improved communication among the staff and oversight personnel responsible for onsite disposal cells and has provided a forum to identify and resolve common concerns.

  11. Investigation of the performance decay of anodic PtRu catalyst with working time of direct methanol fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhen-Bo; Zuo, Peng-Jian; Yin, Ge-Ping [Department of Applied Chemistry, Harbin Institute of Technology, Harbin 150001 (China); Wang, Xin-Peng; Yang, Bo-Qian; Feng, Xian-Ping [Department of Physics, University of Puerto Rico, P.O. Box 23343, San Juan, PR 00931 (United States)

    2008-06-15

    Life tests of direct methanol fuel cells (DMFC) were carried out with three individual single cells at a current density of 100 mA cm{sup -2} for three different times under ambient pressure and at a cell temperature of 60 C. X-ray diffraction (XRD) and X-ray photoelectron spectra (XPS) were used to characterize the anodic PtRu catalysts before and after the life tests. XRD results showed that the particle sizes of anodic catalysts increased from an original value of 2.8 to 3.0, 3.2, and 3.3 nm, whereas their lattice parameters first increased and then decreased from an original value of 3.8761 to 3.8879, 3.8777, and 3.8739 Aa before and after 117, 210, and 312 working hours, respectively. XPS results indicated that during cells' working the contents of Pt and Ru oxides in anodic catalysts increased, but the metal content gradually decreased with test times. Polarization curves, power density curves, and in situ CO-stripping cyclic voltammetric (CV) curves were also plotted to evaluate the performances of fuel cells and electrochemically active surface areas (S{sub EAS}) of anodic catalysts before and after life tests. After different time tests, the performances of DMFC lowered to different extents and could not recover their initial performances. The S{sub EAS} of anodic catalyst decreased slightly by 4.78 and 9.03 m{sup 2} g{sup -1} after 117 and 312 working hours, respectively. The utilization of anodic catalysts lowered slightly. This indicates that the change of (S{sub EAS}) and utilization of anodic catalysts are not the main factors affecting the performance degradation of DMFC. The dissolution of Ru metal from anodic catalysts surface could be one of the main factors for the performance degradation of the PtRu black catalyst. (author)

  12. Pacing the Cell: Walking and Productivity in the Work of Bruce Nauman

    Directory of Open Access Journals (Sweden)

    Ruth Burgon

    2016-12-01

    Full Text Available After graduating from art school in the late 1960s Bruce Nauman found himself pacing his studio, unsure how to produce work as a professional artist. Out of this practice arose several films and videos recording these performances of studio pacing. This paper draws upon Michel Foucault’s Discipline and Punish (1975, translated into English 1977 to shed light upon the aesthetic of confinement and incarceration found in Nauman’s use of the walking body in this early work.

  13. Fermi Potential across Working Solid Oxide Cells with Zirconia or Ceria Electrolytes

    DEFF Research Database (Denmark)

    Jacobsen, Torben; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2014-01-01

    observed for ceria based electrolytes, but also in case of solid oxide electrolyser cells (SOEC) with yttria stabilized zirconia (YSZ) big electronic leak currents have been observed for very high overvoltages on one or both electrodes. Furthermore, it is important to realize that the potential gradient...

  14. Voluntary premarital screening to prevent sickle cell disease in Jamaica: does it work?

    NARCIS (Netherlands)

    Serjeant, G.R.; Serjeant, B.E.; Mason, K.P.; Gibson, F.; Gardner, R.; Warren, L.; Jonker, M.A.

    2017-01-01

    To determine whether identifying haemoglobin genotype, and providing education and counselling to senior school students will influence their choice of partner and reduce the frequency of births with sickle cell disease. The Manchester Project provided free voluntary blood tests to determine

  15. Tuning the ITO work function by capacitively coupled plasma and its application in inverted organic solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Ming [Laboratory of Plasma Physics and Materials, Beijing Institute of Graphic Communication, Beijing (China); Zhang, Chunmei, E-mail: zhangchunmei@bigc.edu.cn [Laboratory of Plasma Physics and Materials, Beijing Institute of Graphic Communication, Beijing (China); Chen, Qiang [Laboratory of Plasma Physics and Materials, Beijing Institute of Graphic Communication, Beijing (China); State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an (China)

    2016-11-01

    Highlights: • The work function of ITO was reduced by plasma treatment. • The reduction of the work function was attributed to the variation in chemical component of ITO surface. • The inverted solar cell without electron transport layer was fabricated using plasma-treated ITO. • Optimal power conversion efficiency of 3.22% was achieved. - Abstract: In this paper, we investigated the performance of inverted organic solar cells (OSCs) with plasma-treated indium tin oxide (ITO) as the cathode for omitting an electron transport layer. The Ar plasma was produced by capcitively coupled plasma setup under 20 Pa chamber pressure. For the device with the structure of plasma-treated ITO/P3HT:PCBM/MoO{sub 3}/Ag, a power conversion efficiency (PCE) of 3.22% was achieved, whereas PCE of 1.13% was recorded from the device fabricated with the pristine ITO. The photovoltaic performance was found to be dependent on the applied power of plasma. After analyzing by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS), we concluded that the chemical component variation of ITOs surface resulted in the decrease of ITO work function, which meant that the ITO Fermi level became shallow relative to the vacuum level. The low work function of ITO should be responsible for the improvement of inverted OSCs because of the better energy level alignment between ITO and the photoactive layer.

  16. Effect of cold working on biocompatibility of Ni-free high nitrogen austenitic stainless steels using Dalton's Lymphoma cell line

    Energy Technology Data Exchange (ETDEWEB)

    Talha, Mohd [Centre of Advanced Study, Department of Metallurgical Engineering, Indian Institute of Technology (Banaras Hindu University) Varanasi 221005, Uttar Pradesh (India); Kumar, Sanjay [Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh (India); Behera, C.K. [Centre of Advanced Study, Department of Metallurgical Engineering, Indian Institute of Technology (Banaras Hindu University) Varanasi 221005, Uttar Pradesh (India); Sinha, O.P., E-mail: opsinha.met@itbhu.ac.in [Centre of Advanced Study, Department of Metallurgical Engineering, Indian Institute of Technology (Banaras Hindu University) Varanasi 221005, Uttar Pradesh (India)

    2014-02-01

    The aims of the present work are to explore the effect of cold working on in-vitro biocompatibility of indigenized low cost Ni-free nitrogen containing austenitic stainless steels (HNSs) and to compare it with conventionally used biomedical grade, i.e. AISI 316L and 316LVM, using Dalton's Lymphoma (DL) cell line. The MTT assay [3-(4,5-dimethythiazol 2-yl)-2,5-diphenyltetrazolium bromide] was performed on DL cell line for cytotoxicity evaluation and cell adhesion test. As a result, it was observed that the HNS had higher cell proliferation and cell growth and it increases by increasing nitrogen content and degree of cold working. The surface wettability of the alloys was also investigated by water contact angle measurements. The value of contact angles was found to decrease with increase in nitrogen content and degree of cold working. This indicates that the hydrophilic character increases with increasing nitrogen content and degree of cold working which further attributed to enhance the surface free energy (SFE) which would be conducive to cell adhesion which in turn increases the cell proliferation. - Graphical abstract: Effect of cold working on in-vitro biocompatibility of indigenized Ni-free nitrogen bearing austenitic stainless steels was explored using Dalton's Lymphoma cell line. Cell proliferation and cell adhesion increase by increasing the degree of cold working and nitrogen content in steel indicating that indigenized material is more biocompatible and no negative effect of cold working on these steels. - Highlights: • Effect of cold working on biocompatibility of Ni-free austenitic stainless steels • Cell proliferation and adhesion increase with nitrogen and degree of cold working. • Contact angle values decrease with nitrogen and degree of cold working.

  17. Mathematical model of a plate fin heat exchanger operating under solid oxide fuel cell working conditions

    Science.gov (United States)

    Kaniowski, Robert; Poniewski, Mieczysław

    2013-12-01

    Heat exchangers of different types find application in power systems based on solid oxide fuel cells (SOFC). Compact plate fin heat exchangers are typically found to perfectly fit systems with power output under 5 kWel. Micro-combined heat and power (micro-CHP) units with solid oxide fuel cells can exhibit high electrical and overall efficiencies, exceeding 85%, respectively. These values can be achieved only when high thermal integration of a system is assured. Selection and sizing of heat exchangers play a crucial role and should be done with caution. Moreover, performance of heat exchangers under variable operating conditions can strongly influence efficiency of the complete system. For that reason, it becomes important to develop high fidelity mathematical models allowing evaluation of heat exchangers under modified operating conditions, in high temperature regimes. Prediction of pressure and temperatures drops at the exit of cold and hot sides are important for system-level studies. Paper presents dedicated mathematical model used for evaluation of a plate fin heat exchanger, operating as a part of micro-CHP unit with solid oxide fuel cells.

  18. Spent metal working fluids produced alterations on photosynthetic parameters and cell-ultrastructure of leaves and roots of maize plants.

    Science.gov (United States)

    Grijalbo, Lucía; Fernandez-Pascual, Mercedes; García-Seco, Daniel; Gutierrez-Mañero, Francisco Javier; Lucas, Jose Antonio

    2013-09-15

    In this work we assess the capacity of maize (Zea mays) plants to phytoremediate spent metal working fluids (MWFs) and its effects on photosynthesis and ultrastructure of mesophyll and root cells. A corn-esparto fibre system patented by us has been used to phytoremediate MWFs in hydroponic culture. Furthermore, a plant growth promoting rhizobacteria (PGPR) has been used to improve the process. The results show that this system is capable of significantly reducing the chemical oxygen demand, under local legislation limits. However, plant systems are really damaged, mainly its photosynthetic system, as shown by the photosynthetical parameters. Nevertheless, strain inoculated improves these parameters, especially Hill reaction. The ultrastructure of photosynthetic apparatus was also affected. Chloroplast number decreased and becomes degraded in the mesophyll of MWFs treated plants. In some cases even plasmolysis of chloroplast membrane was detected. Early senescence symptoms were detected in root ultrastructural study. Severe cellular damage was observed in the parenchymal root cells of plants grown with MWFs, while vascular bundles cell remained unchanged. It seems that the inoculation minimises the damage originated by the MWFs pollutants, appearing as less degenerative organelles and higher chloroplast number than in non-inoculated ones. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Barium Staminate as Semiconductor Working Electrodes for Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Fu-an Guo

    2010-01-01

    Full Text Available Dye-sensitized solar cells (DSSCs are fabricated with perovskite-type BaSnO3 as the photoelectrode materials. Different preparation methods including coprecipitation, hydrothermal, and solid state reaction are employed to synthesize BaSnO3 particles to optimize the photoelectric activities of electrode materials. The photoelectric properties of BaSnO3 particles and the performances of DSSCs are investigated by surface photovoltage spectroscopy and current-voltage measurements. The light-to-electricity conversion of 1.1% is preliminarily reached on the DSSC made of the coprecipitation-derived BaSnO3 particles. Large current density of hole injection into the HOMO level of N719 dye from the valence band of BaSnO3 and reduced photogenerated charge recombination in BaSnO3 could be responsible for the observed solar cell performance of the DSSC fabricated from the coprecipitation-derived BaSnO3 particles.

  20. Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise

    Directory of Open Access Journals (Sweden)

    Robert D Hyldahl

    2014-12-01

    Full Text Available Optimal repair and adaptation of skeletal muscle is facilitated by resident stem cells (satellite cells. To understand how different exercise modes influence satellite cell dynamics, we measured satellite cell activity in conjunction with markers of muscle damage and inflammation in human skeletal muscle following a single work- and intensity-matched bout of eccentric (ECC or concentric contractions (CON. Participants completed a single bout of ECC (n=7 or CON (n=7 of the knee extensors. A muscle biopsy was obtained before and 24 h after exercise. Functional measures and immunohistochemical analyses were used to determine the extent of muscle damage and indices of satellite cell activity. Cytokine concentrations were measured using a multiplexed magnetic bead assay. Isokinetic peak torque decreased following ECC (p<0.05 but not CON. Greater histological staining of the damage marker Xin was observed in muscle samples of ECC vs CON. Tenasin C immunoreactivity increased 15 fold (P<0.01 following ECC and was unchanged following CON. The inflammatory cytokines interferon gamma-induced protein 10 (IP-10 and monocyte chemotactic protein 1 (MCP-1 increased pre- to post-ECC (4.26 ± 1.4 vs. 10.49 ± 5.8 pg/ml, and 3.06 ± 0.7 vs. 6.25 ± 4.6 pg/ml, respectively; p<0.05. There was no change in any cytokine post-CON. Satellite cell content increased 27% pre- to post-ECC (0.10 ± 0.031 vs. 0.127 ± 0.041, respectively; p<0.05. There was no change in satellite cell number in CON (0.099 ± 0.027 vs. 0.102 ± 0.029, respectively. There was no fiber type-specific satellite cell response following either exercise mode. ECC but not CON resulted in an increase in MyoD positive nuclei per myofiber pre- to post-exercise (p<0.05, but there was no change in MyoD DNA binding activity in either condition. In conclusion, ECC but not CON results in functional and histological evidence of muscle damage that is accompanied by increased satellite cell activity 24 h post-exercise.

  1. In situ electrochemical high-energy X-ray diffraction using a capillary working electrode cell geometry.

    Science.gov (United States)

    Young, Matthias J; Bedford, Nicholas M; Jiang, Naisheng; Lin, Deqing; Dai, Liming

    2017-07-01

    The ability to generate new electrochemically active materials for energy generation and storage with improved properties will likely be derived from an understanding of atomic-scale structure/function relationships during electrochemical events. Here, the design and implementation of a new capillary electrochemical cell designed specifically for in situ high-energy X-ray diffraction measurements is described. By increasing the amount of electrochemically active material in the X-ray path while implementing low-Z cell materials with anisotropic scattering profiles, an order of magnitude enhancement in diffracted X-ray signal over traditional cell geometries for multiple electrochemically active materials is demonstrated. This signal improvement is crucial for high-energy X-ray diffraction measurements and subsequent Fourier transformation into atomic pair distribution functions for atomic-scale structural analysis. As an example, clear structural changes in LiCoO2 under reductive and oxidative conditions using the capillary cell are demonstrated, which agree with prior studies. Accurate modeling of the LiCoO2 diffraction data using reverse Monte Carlo simulations further verifies accurate background subtraction and strong signal from the electrochemically active material, enabled by the capillary working electrode geometry.

  2. Putting microbes to work: dairy fermentation, cell factories and bioactive peptides. Part I: overview.

    Science.gov (United States)

    Hayes, Maria; Ross, R Paul; Fitzgerald, Gerald F; Stanton, Catherine

    2007-04-01

    A variety of milk-derived biologically active peptides have been shown to exert both functional and physiological roles in vitro and in vivo, and because of this are of particular interest for food science and nutrition applications. Biological activities associated with such peptides include immunomodulatory, antibacterial, anti-hypertensive and opioid-like properties. Milk proteins are recognized as a primary source of bioactive peptides, which can be encrypted within the amino acid sequence of dairy proteins, requiring proteolysis for release and activation. Fermentation of milk proteins using the proteolytic systems of lactic acid bacteria (LAB) is an attractive approach for generation of functional foods enriched in bioactive peptides given the low cost and positive nutritional image associated with fermented milk drinks and yoghurt. In this review, we discuss the exploitation of such fermentation towards the development of functional foods conferring specific health benefits to the consumer beyond basic nutrition. In particular, in Part I, we focus on the release of encrypted bioactive peptides from a range of food protein sources, as well as the use of LAB as cell factories for the de novo generation of bioactivities.

  3. BCL-x{sub L}/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells

    Energy Technology Data Exchange (ETDEWEB)

    Perri, Mariarita; Yap, Jeremy L.; Yu, Jianshi [Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine Street, Baltimore, MD 21201 (United States); Cione, Erika [Department of Pharmacy, Health and Nutritional Sciences, Ed. Polifunzionale, University of Calabria, 87036 Rende, CS (Italy); Fletcher, Steven [Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine Street, Baltimore, MD 21201 (United States); Kane, Maureen A., E-mail: mkane@rx.umaryland.edu [Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine Street, Baltimore, MD 21201 (United States)

    2014-10-01

    The acute promyelocytic leukemia (APL) subtype of acute myeloid leukemia (AML) is characterized by chromosomal translocations that result in fusion proteins, including the promyelocytic leukemia–retinoic acid receptor, alpha fusion protein (PML–RARα). All-trans retinoic acid (atRA) treatment is the standard drug treatment for APL yielding cure rates >80% by activating transcription and proteasomal degradation of retinoic acid receptor, alpha (RARα). Whereas combination therapy with As{sub 2}O{sub 3} has increased survival further, patients that experience relapse and are refractory to atRA and/or As{sub 2}O{sub 3} is a clinically significant problem. BCL-2 family proteins regulate apoptosis and over-expression of anti-apoptotic B-cell leukemia/lymphoma 2 (BCL-2) family proteins has been associated with chemotherapeutic resistance in APL including impairment of the ability of atRA to induce growth arrest and differentiation. Here we investigated the novel BH3 domain mimetic, JY-1-106, which antagonizes the anti-apoptotic BCL-2 family members B-cell lymphoma-extra large (BCL-x{sub L}) and myeloid cell leukemia-1 (MCL-1) alone and in combination with retinoids including atRA, AM580 (RARα agonist), and SR11253 (RARγ antagonist). JY-1-106 reduced cell viability in HL-60 cells alone and in combination with retinoids. The combination of JY-1-106 and SR11253 had the greatest impact on cell viability by stimulating apoptosis. These studies indicate that dual BCL-x{sub L}/MCL-1 inhibitors and retinoids could work cooperatively in leukemia treatment. - Highlights: • Novel Bcl-x{sub L}/Mcl-1 inhibitor JY-1-106 reduces HL60 cell viability. • JY-1-106 is investigated in combination with retinoic acid, AM580, and SR11253. • AM580 is an RARα agonist; SR11253 is an RARγ antagonist. • Combined use of JY-1-106/SR11253 exhibited the greatest cell viability reduction. • JY-1-106 alone or in combination with retinoids induces apoptosis.

  4. Work plan for phase 1A paleochannel studies at the Cheney disposal cell, Grand Junction, Colorado: Draft

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    This document will serve as a Work Plan for continuing paleochannel characterization activities at the Cheney disposal site near Grand Junction, Colorado. Elevated levels of nitrate were encountered in ground water from two monitor wells installed in alluvial paleochannels near the Cheney disposal cell in 1994. This triggered a series of investigations (Phase 1) designed to determine the source of nitrate and other chemical constituents in ground water at the site. A comprehensive summary of the Phase 1 field investigations (limited to passive monitoring and modeling studies) conducted by the Remedial Action Contractor (RAC) and Technical Assistance Contractor (TAC) to date is provided in Section 2.0 of this document. Results of Phase 1 were inconclusive regarding the potential interaction between the disposal cell and the paleochannels, so additional Phase 1A investigations are planned. Recommendations for Phase 1A tasks and possible future activities are discussed in Section 3.0. Detailed information on the implementation of the proposed Phase 1A tasks appears in Section 4.0 and will provide the basis for Statements of Work (SOW) for each of these tasks. A detailed sampling plan is provided to ensure quality and a consistency with previous data collection efforts.

  5. Energy dispersive X-ray diffraction applied to laboratory investigation on proton exchange membrane water content in working fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Isopo, A.; Rossi Albertini, V. [Istituto di Struttura della Materia - CNR, Roma (Italy); Nobili, F. [Scuola di Scienze e Tecnologie - Sezione Chimica, Universita degli Studi di Camerino (Italy)

    2012-10-15

    An original method, based on the energy-dispersive X-ray diffraction, has been recently proposed as a possible laboratory tool to accomplish long time resolved investigation of the water content in a proton exchange membrane fuel cell. However, this method has never been applied to a real working fuel cell. Therefore, a clear comprehension of its effectiveness in terms of relevant parameters such as time and space resolution, sensitivity, and reproducibility has not yet been achieved. In this paper, all these aspects are discussed and clarified. In order to focus on the method overall effectiveness and on the extent of possible improvements, a basic experimental configuration for both the electrochemical station and the X-ray equipment has been set. The method is described with particular attention to its operating principle and to the evaluation of the errors introduced in data assessment. Finally, applications to some model experiments, in particular working states of the device, are provided and the obtained results are discussed. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  6. Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC.

    Science.gov (United States)

    Rao, S G; Williams, G V; Goldman-Rakic, P S

    1999-04-01

    Studies on the cellular mechanisms of working memory demonstrated that neurons in dorsolateral prefrontal cortex (dPFC) exhibit directionally tuned activity during an oculomotor delayed response. To determine the particular contributions of pyramidal cells and interneurons to spatial tuning in dPFC, we examined both individually and in pairs the tuning properties of regular-spiking (RS) and fast-spiking (FS) units that represent putative pyramidal cells and interneurons, respectively. Our main finding is that FS units possess spatially tuned sensory, motor, and delay activity (i. e., "memory fields") similar to those found in RS units. Furthermore, when recorded simultaneously at the same site, the majority of neighboring neurons, whether FS or RS, displayed isodirectional tuning, i.e., they shared very similar tuning angles for the sensory and delay phases of the task. As the trial entered the response phase of the task, many FS units shifted their direction of tuning and became cross-directional to adjacent RS units by the end of the trial. These results establish that a large part of inhibition in prefrontal cortex is spatially oriented rather than being untuned and simply regulating the threshold response of pyramidal cell output. Moreover, the isodirectional tuning between adjacent neurons supports a functional microcolumnar organization in dPFC for spatial memory fields similar to that found in other areas of cortex for sensory receptive fields.

  7. Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment.

    Science.gov (United States)

    Das, Sudeshna; Mishra, K P; Ganju, Lilly; Singh, S B

    2017-12-15

    Over activation of glial cell derived innate immune factors induces neuro-inflammation that results in neurodegenerative disease, like working memory impairment. In this study, we have investigated the role of andrographolide, a major constituent of Andrographis paniculata plant, in reduction of reactive glial cell derived working memory impairment. Real time PCR, Western bloting, flow cytometric and immunofluorescence studies demonstrated that andrographolide inhibited lipopolysaccharide (LPS)-induced overexpression of HMGB1, TLR4, NFκB, COX-2, iNOS, and release of inflammatory mediators in primary mix glial culture, adult mice prefrontal cortex and hippocampus region. Active microglial and reactive astrocytic makers were also downregulated after andrographolide treatment. Andrographolide suppressed overexpression of microglial MIP-1α, P2X7 receptor and its downstream signaling mediators including-inflammasome NLRP3, caspase1 and mature IL-1β. Furthermore, in vivo maze studies suggested that andrographolide treatment reversed LPS-induced behavioural and working memory disturbances including regulation of expression of protein markers like PKC, p-CREB, amyloid beta, APP, p-tau, synapsin and PSD-95. Andrographolide, by lowering expression of pro apoptotic genes and enhancing the expression of anti-apoptotic gene showed its anti-apoptotic nature that in turn reduces neurodegeneration. Morphology studies using Nissl and FJB staining also showed the neuroprotective effect of andrographolide in the prefrontal cortex region. The above studies indicated that andrographolide prevented neuroinflammation-associated neurodegeneration and improved synaptic plasticity markers in cortical as well as hippocampal region which suggests that andrographolide could be a novel pharmacological countermeasure for the treatment of neuroinflammation and neurological disorders related to memory impairment. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Exposure to metal-working fluids in the automobile industry and the risk of male germ cell tumours.

    Science.gov (United States)

    Behrens, Thomas; Pohlabeln, Hermann; Mester, Birte; Langner, Ingo; Schmeisser, Nils; Ahrens, Wolfgang

    2012-03-01

    In a previous analysis of a case-control study of testicular cancer nested in a cohort of automobile workers, we observed an increased risk for testicular cancer among workers who had ever been involved in occupational metal-cutting tasks. We investigated whether this risk increase was due to exposure to metal-working fluids (MWF). Occupational exposure to MWF was assessed in detail using a job-specific questionnaire for metal-cutting work. We calculated ORs and associated 95% CIs individually matched for age (±2 years) and adjusted for a history of cryptorchidism by conditional logistic regression. The prevalence of exposure to MWF was 39.8% among cases and 40.1% among controls. For total germ cell tumours and seminomas we did not observe risk increases for metal-cutting tasks or occupational exposure to MWF (OR 0.95; 95% CI 0.69 to 1.32 and OR 0.88; 95% CI 0.58 to 1.35, respectively). However, dermal exposure to oil-based MWF was associated with an increased risk for non-seminomatous testicular cancer. Dermal exposure to oil-based MWF for more than 5000 h showed particularly high risk estimates (OR 4.72; 95% CI 1.48 to 15.09). Long-term dermal exposure to oil-based MWF was a risk factor for the development of non-seminomatous testicular germ cell cancer. Possible measures to reduce exposure include the introduction of engineering control measures such as venting or enclosing of machines, and enforcing the use of personal protective equipment during metal cutting.

  9. Tuning of a graphene-electrode work function to enhance the efficiency of organic bulk heterojunction photovoltaic cells with an inverted structure

    Science.gov (United States)

    Jo, Gunho; Na, Seok-In; Oh, Seung-Hwan; Lee, Sangchul; Kim, Tae-Soo; Wang, Gunuk; Choe, Minhyeok; Park, Woojin; Yoon, Jongwon; Kim, Dong-Yu; Kahng, Yung Ho; Lee, Takhee

    2010-11-01

    We demonstrate the fabrication of inverted-structure organic solar cells (OSCs) with graphene cathodes. The graphene film used in this work was work-function-engineered with an interfacial dipole layer to reduce the work function of graphene, which resulted in an increase in the built-in potential and enhancement of the charge extraction, thereby enhancing the overall device performance. Our demonstration of inverted-structure OSCs with work-function-engineering of graphene electrodes will foster the fabrication of more advanced structure OSCs with higher efficiency.

  10. Low Work Function Lacunary Polyoxometalates as Electron Transport Interlayers for Inverted Polymer Solar Cells of Improved Efficiency and Stability.

    Science.gov (United States)

    Tountas, Marinos; Topal, Yasemin; Polydorou, Ermioni; Soultati, Anastasia; Verykios, Apostolis; Kaltzoglou, Andreas; Papadopoulos, Theodoros A; Auras, Florian; Seintis, Kostas; Fakis, Mihalis; Palilis, Leonidas C; Tsikritzis, Dimitris; Kennou, Stella; Koutsoureli, Matroni; Papaioannou, George; Ersöz, Mustafa; Kus, Mahmut; Falaras, Polycarpos; Davazoglou, Dimitris; Argitis, Panagiotis; Vasilopoulou, Maria

    2017-07-12

    Effective interface engineering has been shown to play a vital role in facilitating efficient charge-carrier transport, thus boosting the performance of organic photovoltaic devices. Herein, we employ water-soluble lacunary polyoxometalates (POMs) as multifunctional interlayers between the titanium dioxide (TiO2) electron extraction/transport layer and the organic photoactive film to simultaneously enhance the efficiency, lifetime, and photostability of polymer solar cells (PSCs). A significant reduction in the work function (WF) of TiO2 upon POM utilization was observed, with the magnitude being controlled by the negative charge of the anion and the selection of the addenda atom (W or Mo). By inserting a POM interlayer with ∼10 nm thickness into the device structure, a significant improvement in the power conversion efficiency was obtained; the optimized POM-modified poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro-2-[(2- 33 ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl

  11. Group Work.

    Science.gov (United States)

    Wilson, Kristy J; Brickman, Peggy; Brame, Cynthia J

    2018-01-01

    Science, technology, engineering, and mathematics faculty are increasingly incorporating both formal and informal group work in their courses. Implementing group work can be improved by an understanding of the extensive body of educational research studies on this topic. This essay describes an online, evidence-based teaching guide published by CBE-Life Sciences Education ( LSE ). The guide provides a tour of research studies and resources related to group work (including many articles from LSE ). Instructors who are new to group work, as well as instructors who have experienced difficulties in implementing group work, may value the condensed summaries of key research findings. These summaries are organized by teaching challenges, and actionable advice is provided in a checklist for instructors. Education researchers may value the inclusion of empirical studies, key reviews, and meta-analyses of group-work studies. In addition to describing key features of the guide, this essay also identifies areas in which further empirical studies are warranted. © 2018 K. J. Wilson et al. CBE—Life Sciences Education © 2018 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6.

    Science.gov (United States)

    Cao, Guoshuai; Wang, Jian; Zheng, Xiaodong; Wei, Haiming; Tian, Zhigang; Sun, Rui

    2015-12-11

    Immune cells are believed to participate in initiating anti-tumor effects during regular tumor therapy such as chemotherapy, radiation, hyperthermia, and cytokine injection. One of the mechanisms underlying this process is the expression of so-called stress-inducible immunostimulating ligands. Although the activating receptor NKG2D has been proven to play roles in tumor therapy through targeting its ligands, the role of NKp30, another key activating receptor, is seldom addressed. In this study, we found that the NKp30 ligand B7-H6 was widely expressed in tumor cells and closely correlated to their susceptibility to NK cell lysis. Further studies showed that treatment of tumor cells with almost all standard tumor therapeutics, including chemotherapy (cisplatin, 5-fluorouracil), radiation therapy, non-lethal heat shock, and cytokine therapy (TNF-α), could up-regulate the expression of B7-H6 in tumor cells and enhance tumor sensitivity to NK cell cytolysis. B7-H6 shRNA treatment effectively dampened sensitization of tumor cells to NK-mediated lysis. Our study not only reveals the possibility that tumor therapeutics work as stress inducers to enhance tumor sensitivity to NK cell cytolysis but also suggests that B7-H6 could be a potential target for tumor therapy in the future. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Molecular and Cellular Characterization of Space Flight Effects on Microvascular Endothelial Cell Function - PreparatoryWork for the SFEF Project

    Science.gov (United States)

    Balsamo, Michele; Barravecchia, Ivana; Mariotti, Sara; Merenda, Alessandra; De Cesari, Chiara; Vukich, Marco; Angeloni, Debora

    2014-12-01

    Exposure to microgravity during space flight (SF) of variable length induces suffering of the endothelium (the cells lining all blood vessels), mostly responsible for health problems found in astronauts and animals returning from space. Of interest to pre-nosological medicine, the effects of microgravity on astronauts are strikingly similar to the consequences of sedentary life, senescence and degenerative diseases on Earth, although SF effects are accelerated and reversible. Thus, microgravity is a significant novel model for better understanding of common pathologies. A comprehensive cell and molecular biology study is needed in order to explain pathophysiological findings after SFs. This project will study the effects of microgravity and cosmic radiation on endothelial cells (ECs) cultured on the International Space Station through analysis of 1) cell transcriptome, 2) DNA methylome, 3) DNA damage and cell senescence, 4) variations in cell cycle and cell morphology. This project has been selected by the European Space Agency and the Italian Space Agency and is presently in preparation. The ground study presented here was performed to determine the biological and engineering requirements that will allow us to retrieve suitable samples after culturing, fixing and storing ECs in space. We expect to identify molecular pathways activated by space microgravity in microvascular ECs, which may shed light on pathogenic molecular mechanisms responsible for endothelial suffering shared by astronauts and individuals affected with aging, degenerative and sedentary life-associated pathologies on Earth.

  14. Boosting the power conversion efficiency of perovskite solar cells using self-organized polymeric hole extraction layers with high work function.

    Science.gov (United States)

    Lim, Kyung-Geun; Kim, Hak-Beom; Jeong, Jaeki; Kim, Hobeom; Kim, Jin Young; Lee, Tae-Woo

    2014-10-08

    A self-organized hole extraction layer (SOHEL) with high work function (WF) is designed for energy level alignment with the ionization potential level of CH3 NH3 PbI3 . The SOHEL increases the built-in potential, photocurrent, and power conversion efficiency (PCE) of CH3 NH3 PbI3 perovskite solar cells. Thus, interface engineering of the positive electrode of solution-processed planar heterojunction solar cells using a high-WF SOHEL is a very effective way to achieve high device efficiency (PCE = 11.7% on glass). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Allogeneic stem cell transplantation in patients with aggressive primary cutaneous T-cell lymphoma - a case series of the ADF working group "cutaneous lymphomas".

    Science.gov (United States)

    Moritz, Rose K C; Ditschkowski, Markus; Klemke, Claus-Detlev; Terras, Sarah; Schlaak, Max; Knorr, Martin; Theurich, Sebastian; Hegenbart, Ute; Kremens, Bernhard; Beelen, Dietrich W; Stücker, Markus; Kreuter, Alexander

    2014-01-01

    Allogeneic stem cell transplantation (alloSCT) is a treatment option for primary cutaneous T-cell lymphomas that may induce long-lasting complete remissions. Little information is available on safety and efficacy. We retrospectively reviewed the data from patients with primary cutaneous T-cell lymphoma treated in the Departments of Dermatology of the Universities of Bochum, Mannheim and Cologne who received subsequent alloSCT between 2005 and 2012. Nine patients with aggressive primary cutaneous T-cell-lymphoma received alloSCT. With a follow-up of 14 to 36 months after transplantation, 4 patients are alive and in complete remission. Two patients had recurrent disease post-transplantation, which was successfully treated with donor lymphocyte infusions. Non-relapse mortality was observed in three patients in advanced disease stages within six months after alloSCT. One patient showed only partial remission and died of disease after 32 months and one patient died 26 months after alloSCT with cause of death unknown. This report documents the possible benefit of a graft-versus-lymphoma effect in primary cutaneous T-cell lymphoma, as has been observed for other T-cell malignancies and emphasizes that alloSCT warrants further studies in this setting. © 2014 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  16. Do the Defects Make It Work? Defect Engineering in Pi-Conjugated Polymers and Their Solar Cells: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wang, D.; Reese, M.; Kopidakis N.; Gregg, B. A.

    2008-05-01

    The charged defect density in common pi-conjugated polymers such as poly(3-hexylthiophene), P3HT, is around 1018 cm-3. Despite, or perhaps because of, this huge defect density, bulk heterojunction solar cells made from these polymers and a C60 derivative such as PCBM exhibit some of the highest efficiencies (~5%) yet obtained in solid state organic photovoltaic cells. We discuss defects in molecular organic semiconductors and in pi-conjugated polymers. These defects can be grouped in two categories, covalent and noncovalent. Somewhat analogous to treating amorphous silicon with hydrogen, we introduce chemical methods to modify the density and charge of the covalent defects in P3HT by treating it with electrophiles such as dimethyl sulfate and nucleophiles such as sodium methoxide. The effects of these treatments on the electrical and photovoltaic properties and stability of organic PV cells is discussed in terms of the change in the number and chemical properties of the defects. Finally, we address the question of whether the efficiency of OPV cells requires the presence of these defects which function as adventitious p-type dopants. Their presence relieves the resistance limitations usually encountered in cleaner organic semiconductors and can create built-in electric fields at junctions.

  17. Improved Work Function of Poly(3,4-ethylenedioxythiophene): Poly(styrenesulfonic acid) and its Effect on Hybrid Silicon/Organic Heterojunction Solar Cells

    Science.gov (United States)

    Shen, Xiaojuan; Chen, Ling; Pan, Jianmei; Hu, Yue; Li, Songjun; Zhao, Jie

    2016-11-01

    Hybrid silicon/organic solar cells have been recently extensively investigated due to their simple structure and low-cost fabrication process. However, the efficiency of the solar cells is greatly limited by the barrier height as well as the carrier recombination at the silicon/organic interface. In this work, hydrochloroplatinic acid (H2PtCl6) is employed into the poly(3,4-ethlenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) solution, and the work function (WF) of the PEDOT:PSS layer has been successfully improved. Based on the Pt-modified PEDOT:PSS layer, the efficiency of the silicon/PEDOT:PSS cell can be increased to 11.46%, corresponding to 20% enhancement to the one without platinum (Pt) modification. Theoretical and experimental results show that, when increasing the WF of the PEDO:PSS layer, the barrier height between the silicon/PEDOT:PSS interface can be effectively enhanced. Meanwhile, the carrier recombination at the interface is significantly reduced. These results can contribute to better understanding of the interfacial mechanism of silicon/PEDOT:PSS interface, and further improving the device performance of silicon/organic solar cells.

  18. "From Snail Mode to Rocket Ship Mode": Adolescents and Young Adults' Experiences of Returning to Work and School After Hematopoietic Cell Transplantation.

    Science.gov (United States)

    Brauer, Eden R; Pieters, Huibrie C; Ganz, Patricia A; Landier, Wendy; Pavlish, Carol; Heilemann, MarySue V

    2017-12-01

    Resuming normal activities, such as work and school, is an important dimension of psychosocial recovery in cancer survivorship. Minimal data exist regarding adolescents or young adults' experiences of returning to school or work after cancer. The purpose of this study was to explore the processes of resuming work and school among adolescents and young adults after hematopoietic cell transplantation (HCT). In-depth interviews were conducted with 18 adolescents and young adults, who were 15-29 years when they underwent HCT and 6-60 months post-transplant at study enrollment. Interview transcripts were systematically analyzed using Grounded Theory methodology. Participants described the context in which they attempted to return to work or school, specific challenges they faced, and strategies they developed in these environments. Feeling left behind from their peers and their pre-diagnosis selves, participants described "rushing" back to school and work impulsively, taking on too much too quickly while facing overwhelming physical and cognitive demands. Factors motivating this sense of urgency as well as barriers to successful and sustainable reentry in these settings are also addressed. Findings are discussed in the context of important opportunities for clinical management, age-appropriate interventions, and implications for future research. A better understanding of psychosocial late effects, specifically related to school and work trajectories after cancer, is critical to survivorship care for adolescent and young adult cancer survivors.

  19. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.

    Science.gov (United States)

    Li, Xiaohan; Kikuchi, Keiji; Takano, Yasuo

    2011-01-01

    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world. The evolution and progression of HNSCC are considered to result from multiple stepwise alterations of cellular and molecular pathways in squamous epithelium. Recently, inhibitor of growth gene (ING) family consisting of five genes, ING1 to ING5, was identified as a new tumor suppressor gene family that was implicated in the downregulation of cell cycle and chromatin remodeling. In contrast, it has been shown that ING1 and ING2 play an oncogenic role in some cancers, this situation being similar to TGF-β. In HNSCC, the ING family has been reported to be downregulated, and ING translocation from the nucleus to the cytoplasm may be a critical event for carcinogenesis. In this paper, we describe our recent results and briefly summarize current knowledge regarding the biologic functions of ING in HNSCC.

  20. The photovoltaic performance of CdS quantum dots sensitized solar cell using graphene/TiO2 working electrode

    Science.gov (United States)

    Badawi, Ali; Al-Hosiny, N.; Abdallah, S.

    2015-05-01

    Graphene/titania (G/TiO2) nanocomposite photoanodes were fabricated for CdS quantum dots sensitized solar cells (QDSSCs) applications. The effect of G/TiO2 ratio (0, 0.1, 0.2, 0.5, and 1.0 wt.%) on the photovoltaic performance of CdS QDSSCs was investigated. CdS QDs were deposited onto G/TiO2 nanocomposite films by successive ionic layer adsorption and reaction (SILAR) technique for six cycles. The current density-voltage (J-V) characteristic curves of the assembled solar cells were measured at AM1.5 simulated sunlight. The optimal G/TiO2 ratio was 0.2 wt.% for photovoltaic performance. CdS QDSSCs based on 0.2 wt.% G/TiO2 nanocomposite photoanode achieve 32% increase in conversion efficiency (η) compared with those based on plain TiO2 NPs photoanode. The photovoltage-decay curves of the assembled cell were recorded. The electron-hole back recombination rates decrease significantly for CdS QDSSCs based on 0.2 wt.% ratio of G/TiO2 nanocomposite photoanode. The lifetime constants (τ) is much larger for CdS QDSSCs based on 0.2 wt.% ratio of G/TiO2 nanocomposite photoanode compared to those based on plain TiO2 NPs photoanodes.

  1. MoS2 Quantum Dots with a Tunable Work Function for High-Performance Organic Solar Cells.

    Science.gov (United States)

    Xing, Wang; Chen, Yusheng; Wang, Xinlong; Lv, Lei; Ouyang, Xinhua; Ge, Ziyi; Huang, Hui

    2016-10-12

    An efficient hole extraction layer (HEL) is critical to achieve high-performance organic solar cells (OSCs). In this study, we developed a pinhole-free and efficient HEL based on MoS2 quantum dots (QDs) combined with UV-ozone (UVO) treatment. The optophysical properties and morphology of MoS2 QDs and their photovoltaic performance are investigated. The results showed that MoS2 QDs can form homogeneous films and can be applied as an interfacial layer not only for donors with shallow highest occupied molecular orbital (HOMO) but also for those with deep HOMO energy levels after UVO treatment (O-MoS2 QDs). The solar cells based on O-MoS2 QDs yield a power conversion efficiency (PCE) of 8.66%, which is 71% and 12% higher than those of the OSCs with pristine MoS2 QD and O-MoS2 nanosheets, respectively, and the highest PCEs for OSCs containing MoS2 materials. Furthermore, the stability of solar cells based on MoS2 QDs is greatly improved in comparison with state-of-the-art PEDOT:PSS. These results demonstrate the great potential of O-MoS2 QDs as an efficient HEL for high-performance OSCs.

  2. The effects of black garlic on the working memory and pyramidal cell number of medial prefrontal cortex of rats exposed to monosodium glutamate.

    Science.gov (United States)

    Nurmasitoh, Titis; Sari, Dwi Cahyani Ratna; Partadiredja, Ginus

    2017-12-27

    Monosodium glutamate-induced exitotoxicity causes oxidative stress in many brain areas, including the medial prefrontal cortex. The ethanolic garlic (Allium sativum) extract is considered as a neuroprotective substance. The present study aimed at investigating the effects of the ethanolic fermented garlic extract on the working memory and the pyramidal cell number of the medial prefrontal cortex of adolescent male Wistar rats exposed to monosodium glutamate (MSG). Twenty-five rats were randomly divided into five groups. The C- group was given 0.9% NaCl solution. The C + group was given 2 mg/g bw of MSG. The T1, T2, and T3 groups were given MSG and garlic extract (0.0125, 0.025, and 0.05 mg/g bw, respectively). All treatments were conducted for 10 days. The working memory capability of the rats was measured using Y-maze test. The total number of pyramidal cells of the medial prefrontal cortex was estimated using physical fractionator method. The working memory performances of the T1, T2, and T3 groups were significantly better than that of the C + group. There were no significant differences between groups in the estimated total number of pyramidal cell of medial prefrontal cortex. The MSG may not cause the death of neurons, but it may modify neuronal architectures that are sufficient to disrupt memory functions. Black garlic may play a role as an antioxidant agent that prevents the prefrontal cortex from glutamate-induced oxidative stress. It is concluded that the ethanolic fermented garlic extract prevented the working memory impairment following MSG administration.

  3. Novel nanostructure zinc zirconate, zinc oxide or zirconium oxide pastes coated on fluorine doped tin oxide thin film as photoelectrochemical working electrodes for dye-sensitized solar cell.

    Science.gov (United States)

    Hossein Habibi, Mohammad; Askari, Elham; Habibi, Mehdi; Zendehdel, Mahmoud

    2013-03-01

    Zinc zirconate (ZnZrO(3)) (ZZ), zinc oxide (ZnO) (ZO) and zirconium oxide (ZrO(2)) (ZRO) nano-particles were synthesized by simple sol-gel method. ZZ, ZO and ZRO nano-particles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and UV-Vis diffuse reflectance spectrum (DRS). Nanoporous ZZ, ZO and ZRO thin films were prepared doctor blade technique on the fluorine-doped tin oxide (FTO) and used as working electrodes in dye sensitized solar cells (DSSC). Their photovoltaic behavior were compared with standard using D35 dye and an electrolyte containing [Co(bpy)(3)](PF(6))(2), [Co(pby)(3)](PF(6))(3), LiClO(4), and 4-tert-butylpyridine (TBP). The properties of DSSC have been studied by measuring their short-circuit photocurrent density (Jsc), open-circuit voltage (VOC) and fill factor (ff). The application of ZnZrO(3) as working electrode produces a significant improvement in the fill factor (ff) of the dye-sensitized solar cells (ff=56%) compared to ZnO working electrode (ff=40%) under the same condition. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Research Methodology and Study Design Working Group Report.

    Science.gov (United States)

    Shaw, Bronwen E; Hahn, Theresa; Martin, Paul J; Mitchell, Sandra A; Petersdorf, Effie W; Armstrong, Gregory T; Shelburne, Nonniekaye; Storer, Barry E; Bhatia, Smita

    2017-01-01

    The increasing numbers of hematopoietic cell transplantations (HCTs) performed each year, the changing demographics of HCT recipients, the introduction of new transplantation strategies, incremental improvement in survival, and the growing population of HCT survivors demand a comprehensive approach to examining the health and well-being of patients throughout life after HCT. This report summarizes strategies for the conduct of research on late effects after transplantation, including consideration of the study design and analytic approaches; methodologic challenges in handling complex phenotype data; an appreciation of the changing trends in the practice of transplantation; and the availability of biospecimens to support laboratory-based research. It is hoped that these concepts will promote continued research and facilitate the development of new approaches to address fundamental questions in transplantation outcomes. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  5. How molecular motors work in the crowded environment of living cells: coexistence and efficiency of normal and anomalous transport.

    Directory of Open Access Journals (Sweden)

    Igor Goychuk

    Full Text Available Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included.

  6. Ion Implantation-Modified Fluorine-Doped Tin Oxide by Zirconium with Continuously Tunable Work Function and Its Application in Perovskite Solar Cells.

    Science.gov (United States)

    Han, Dong; Wu, Cuncun; Zhao, Yunbiao; Chen, Yi; Xiao, Lixin; Zhao, Ziqiang

    2017-12-06

    In recent years, perovskite solar cells have drawn a widespread attention. As an electrode material, fluorine-doped tin oxide (FTO) is widely used in various kinds of solar cells. However, the relatively low work function (WF) (∼4.6 eV) limits its application. The potential barrier between the transparent conductive oxide electrode and the hole transport layer (HTL) in inverted perovskite solar cells results in a decrease in device performance. In this paper, we propose a method to adjust WF of FTO by implanting zirconium ions into the FTO surface. The WF of FTO can be precisely and continuously tuned between 4.59 and 5.55 eV through different dopant concentration of zirconium. In the meantime, the modified FTO, which had a WF of 5.1 eV to match well the highest occupied molecular orbital energy level of poly(3,4-ethylenedioxylenethiophene):polystyrene sulfonate, was used as the HTL in inverted planar perovskite solar cells. Compared with the pristine FTO electrode-based device, the open circuit voltage increased from 0.82 to 0.91 V, and the power conversion efficiency increased from 11.6 to 14.0%.

  7. In situ electrochemical high-energy X-ray diffraction using a capillary working electrode cell geometry

    Energy Technology Data Exchange (ETDEWEB)

    Young, Matthias J.; Bedford, Nicholas M.; Jiang, Naisheng; Lin, Deqing; Dai, Liming

    2017-05-26

    The ability to generate new electrochemically active materials for energy generation and storage with improved properties will likely be derived from an understanding of atomic-scale structure/function relationships during electrochemical events. Here, the design and implementation of a new capillary electrochemical cell designed specifically forin situhigh-energy X-ray diffraction measurements is described. By increasing the amount of electrochemically active material in the X-ray path while implementing low-Zcell materials with anisotropic scattering profiles, an order of magnitude enhancement in diffracted X-ray signal over traditional cell geometries for multiple electrochemically active materials is demonstrated. This signal improvement is crucial for high-energy X-ray diffraction measurements and subsequent Fourier transformation into atomic pair distribution functions for atomic-scale structural analysis. As an example, clear structural changes in LiCoO2under reductive and oxidative conditions using the capillary cell are demonstrated, which agree with prior studies. Accurate modeling of the LiCoO2diffraction data using reverse Monte Carlo simulations further verifies accurate background subtraction and strong signal from the electrochemically active material, enabled by the capillary working electrode geometry.

  8. Low Work-function Poly(3,4-ethylenedioxylenethiophene): Poly(styrene sulfonate) as Electron-transport Layer for High-efficient and Stable Polymer Solar Cells

    OpenAIRE

    Yong Zhang; Lie Chen; Xiaotian Hu; Lin Zhang,; Yiwang Chen

    2015-01-01

    Low-work-function poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) modified with polyethylenimine (PEIE) was used as an electron transport layer (ETL) for polymer solar cells (PSCs). A thin layer of PEIE film was spin-coated onto the surface on the PEDOT:PSS films, thus substantially changing their charge selectivity from supporting hole transport to supporting electron transport. It was also found that the PEDOT:PSS/PEIE ETL exhibited higher interfacial contact, a more fa...

  9. Poetry, science and hope in the Prose des cellules HeLa (prose for the HeLa cells) in Marcel Thiry’s poetic work

    OpenAIRE

    Halen, Pierre

    2014-01-01

    International audience; If the process of natural sciences, so-called “exact sciences”, can be enlightened by theology and philosophy, it can also be seen by a literary gaze, and in this case by a poetic approach. A work published in 1969 by the Belgian poet Marcel Thiry, entitled Prose des cellules HeLa (prose for the HeLa cells), shows the possibility for knowledges to hold a dialogue which brings out their complementary nature. Using resources of various worldviews (myths from Greek Antiqu...

  10. Langerhans Cell Histiocytosis (LCH): Guidelines for Diagnosis, Clinical Work-Up, and Treatment for Patients Till the Age of 18 Years

    Science.gov (United States)

    Haupt, Riccardo; Minkov, Milen; Astigarraga, Itziar; Schäfer, Eva; Nanduri, Vasanta; Jubran, Rima; Egeler, R Maarten; Janka, Gritta; Micic, Dragan; Rodriguez-Galindo, Carlos; Van Gool, Stefaan; Visser, Johannes; Weitzman, Sheila; Donadieu, Jean

    2013-01-01

    These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work-up, and treatment and long-term follow-up of LCH patients are presented. PMID:23109216

  11. Study of working pressure on the optoelectrical properties of Al–Y codoped ZnO thin-film deposited using DC magnetron sputtering for solar cell applications

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Feng-Hao [Institute of Microelectronics, Department of Electrical Engineering, National Cheng Kung University, No. 1, Dasyue Road, East District, Tainan City 701, Taiwan (China); Wang, Na-Fu; Tsai, Yu-Zen; Chuang, Ming-Chieh; Cheng, Yu-Song [Department of Electronic Engineering, Cheng Shiu University, 840 Chengcing Road, Niaosong District, Kaohsiung City 833, Taiwan (China); Houng, Mau-Phon, E-mail: mphoung@eembox.ncku.edu.tw [Institute of Microelectronics, Department of Electrical Engineering, National Cheng Kung University, No. 1, Dasyue Road, East District, Tainan City 701, Taiwan (China)

    2013-09-01

    Low cost transparent conductive Al–Y codoped ZnO (AZOY) thin-films were prepared on a glass substrate using a DC magnetron sputtering technique with various working pressures in the range of 5–13 mTorr. The relationship among the structural, electrical, and optical properties of sputtered AZOY films was studied as a function of working pressure. The XRD measurements show that the crystallinity of the films degraded as the working gas pressure increased. The AZOY thin-film deposited at a working pressure of 5 mTorr exhibited the lowest electrical resistivity of 4.3 × 10{sup −4} Ω cm, carrier mobility of 30 cm{sup 2}/V s, highest carrier concentration of 4.9 × 10{sup 20} cm{sup −3}, and high transmittance in the visible region (400–800 nm) of approximately 90%. Compared with Al doped ZnO (AZO) thin-films deposited using DC or RF magnetron sputtering methods, a high carrier mobility was observed in our AZOY thin-films. This result can be used to effectively decrease the absorption of near infrared-rays in solar cell applications. The mechanisms are attributed to the larger transition energy between Ar atoms and sputtering particles and the size compensation of the dopants. Finally, the optimal quality AZOY thin-film was used as an emitter layer (or window layer) to form AZOY/n-Si heterojunction solar cells, which exhibited a stable conversion efficiency (η) of 9.4% under an AM1.5 illumination condition.

  12. Return to work for patients with diffuse large B-cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation

    DEFF Research Database (Denmark)

    Arboe, Bente; Olsen, Maja Halgren; Goerloev, Jette Soenderskov

    2017-01-01

    followed until RTW, disability or old-age pension, death, or December 31, 2015, whichever came first. A total of 205 patients were followed with disability pension as the event of interest. Cox models were used to determine cause-specific hazards. RESULTS: During follow-up, 82 (50%) patients returned...... to work. The rate of returning to work in the first year following ASCT was decreased for patients being on sick leave at the time of relapse (hazard ratio [HR] 0.3 [0.2;0.5]) and increased for patients aged ≥55 years (HR 1.9 [1.1;3.3]). In all, 56 (27%) patients were granted disability pension. Being...... on sick leave at the time of relapse was positively associated with receiving a disability pension in the first 2 years after ASCT (HR 3.7 [1.8;7.7]). CONCLUSION: Patients on sick leave at the time of relapse have a poorer prognosis regarding RTW and have a higher rate of disability pension. Furthermore...

  13. Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group.

    Science.gov (United States)

    Manola, Judith; Royston, Patrick; Elson, Paul; McCormack, Jennifer Bacik; Mazumdar, Madhu; Négrier, Sylvie; Escudier, Bernard; Eisen, Tim; Dutcher, Janice; Atkins, Michael; Heng, Daniel Y C; Choueiri, Toni K; Motzer, Robert; Bukowski, Ronald

    2011-08-15

    To develop a single validated model for survival in metastatic renal cell carcinoma (mRCC) using a comprehensive international database. A comprehensive database of 3,748 patients including previously reported clinical prognostic factors was established by pooling patient-level data from clinical trials. Following quality control and standardization, descriptive statistics were generated. Univariate analyses were conducted using proportional hazards models. Multivariable analysis using a log-logistic model stratified by center and multivariable fractional polynomials was conducted to identify independent predictors of survival. Missing data were handled using multiple imputation methods. Three risk groups were formed using the 25th and 75th percentiles of the resulting prognostic index. The model was validated using an independent data set of 645 patients treated with tyrosine kinase inhibitor (TKI) therapy. Median survival in the favorable, intermediate and poor risk groups was 26.9 months, 11.5 months, and 4.2 months, respectively. Factors contributing to the prognostic index included treatment, performance status, number of metastatic sites, time from diagnosis to treatment, and pretreatment hemoglobin, white blood count, lactate dehydrogenase, alkaline phosphatase, and serum calcium. The model showed good concordance when tested among patients treated with TKI therapy (C statistic = 0.741, 95% CI: 0.714-0.768). Nine clinical factors can be used to model survival in mRCC and form distinct prognostic groups. The model shows utility among patients treated in the TKI era. ©2011 AACR.

  14. Mobility Work

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Bossen, Claus

    2005-01-01

    We posit the concept of Mobility Work to describe efforts of moving about people and things as part of accomplishing tasks. Mobility work can be seen as a spatial parallel to the concept of articulation work proposed by the sociologist Anselm Strauss. Articulation work describes efforts...... of coordination necessary in cooperative work, but focuses, we argue, mainly on the temporal aspects of cooperative work. As a supplement, the concept of mobility work focuses on the spatial aspects of cooperative work. Whereas actors seek to diminish the amount of articulation work needed in collaboration...... by constructing Standard Operation Procedures (SOPs), actors minimise mobility work by constructing Standard Operation Configurations (SOCs). We apply the concept of mobility work to the ethnography of hospital work, and argue that mobility arises because of the need to get access to people, places, knowledge and...

  15. Stereotactic body radiotherapy for renal cell cancer and pancreatic cancer : Literature review and practice recommendations of the DEGRO Working Group on Stereotactic Radiotherapy.

    Science.gov (United States)

    Panje, Cédric; Andratschke, Nikolaus; Brunner, Thomas B; Niyazi, Maximilian; Guckenberger, Matthias

    2016-12-01

    This report of the Working Group on Stereotactic Radiotherapy of the German Society of Radiation Oncology (DEGRO) aims to provide a literature review and practice recommendations for stereotactic body radiotherapy (SBRT) of primary renal cell cancer and primary pancreatic cancer. A literature search on SBRT for both renal cancer and pancreatic cancer was performed with focus on prospective trials and technical aspects for clinical implementation. Data on renal and pancreatic SBRT are limited, but show promising rates of local control for both treatment sites. For pancreatic cancer, fractionated SBRT should be preferred to single-dose treatment to reduce the risk of gastrointestinal toxicity. Motion-compensation strategies and image guidance are paramount for safe SBRT delivery in both tumor entities. SBRT for renal cancer and pancreatic cancer have been successfully evaluated in phase I and phase II trials. Pancreatic SBRT should be practiced carefully and only within prospective protocols due to the risk of severe gastrointestinal toxicity. SBRT for primary renal cell cancer appears a viable option for medically inoperable patients but future research needs to better define patient selection criteria and the detailed practice of SBRT.

  16. Improved open-circuit voltage in Cu(In,Ga)Se{sub 2} solar cells with high work function transparent electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Jäger, Timo, E-mail: timo.jaeger@empa.ch; Romanyuk, Yaroslav E.; Bissig, Benjamin; Pianezzi, Fabian; Nishiwaki, Shiro; Reinhard, Patrick; Steinhauser, Jérôme; Tiwari, Ayodhya N. [Empa—Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Thin Films and Photovoltaics, Überlandstrasse 129, 8600 Dübendorf (Switzerland); Schwenk, Johannes [Empa—Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Nanoscale Materials Science, Überlandstrasse 129, 8600 Dübendorf (Switzerland)

    2015-06-14

    Hydrogenated indium oxide (IOH) is implemented as transparent front contact in Cu(In,Ga)Se{sub 2} (CIGS) solar cells, leading to an open circuit voltage V{sub OC} enhanced by ∼20 mV as compared to reference devices with ZnO:Al (AZO) electrodes. This effect is reproducible in a wide range of contact sheet resistances corresponding to various IOH thicknesses. We present the detailed electrical characterization of glass/Mo/CIGS/CdS/intrinsic ZnO (i-ZnO)/transparent conductive oxide (TCO) with different IOH/AZO ratios in the front TCO contact in order to identify possible reasons for the enhanced V{sub OC}. Temperature and illumination intensity-dependent current-voltage measurements indicate that the dominant recombination path does not change when AZO is replaced by IOH, and it is mainly limited to recombination in the space charge region and at the junction interface of the solar cell. The main finding is that the introduction of even a 5 nm-thin IOH layer at the i-ZnO/TCO interface already results in a step-like increase in V{sub OC}. Two possible explanations are proposed and verified by one-dimensional simulations using the SCAPS software. First, a higher work function of IOH as compared to AZO is simulated to yield an V{sub OC} increase by 21 mV. Second, a lower defect density in the i-ZnO layer as a result of the reduced sputter damage during milder sputter-deposition of IOH can also add to a maximum enhanced V{sub OC} of 25 mV. Our results demonstrate that the proper choice of the front TCO contact can reduce the parasitic recombination and boost the efficiency of CIGS cells with improved corrosion stability.

  17. Highly sensitive assays are mandatory for the differential diagnosis of patients presenting with symptoms of mast cell activation: diagnostic work-up of 38 patients.

    Science.gov (United States)

    Van den Poel, Bea; Kochuyt, Anne-Marie; Del Biondo, Elke; Dewaele, Barbara; Lierman, Els; Tousseyn, Thomas; de Hertogh, Gert; Vandenberghe, Peter; Boeckx, Nancy

    2017-04-01

    Mastocytosis is a heterogeneous disease caused by excessive mast cell (MC) proliferation. Diagnosis of systemic mastocytosis (SM) is based on the presence of major and minor criteria defined by the World Health Organization. Symptoms of MC activation can also occur in patients without SM or without allergic or inflammatory disease. These MC activation syndromes (MCAS) can be divided into primary (monoclonal) MCAS (MMAS) vs. secondary and idiopathic MCAS. In this single center study, the diagnostic work-up of 38 patients with a clinical suspicion of SM and/or with elevated basic tryptase levels is presented. Clinical symptoms, biochemical parameters, results of bone marrow investigation, flow cytometric immunophenotyping, and molecular analysis were retrospectively reviewed. Twenty-three patients were found to have a monoclonal MC disorder of which 19 were diagnosed with SM and 4 with MMAS. In 13/19 SM patients, multifocal MC infiltrates in the bone marrow were found (major criterion), while in 6 the diagnosis was based on the presence of ≥3 minor criteria. Flow cytometric analysis of bone marrow showed CD25 expression of MCs in all patients with SM and MMAS (range: 0.002-0.3% of cells). In bone marrow, the KIT D816V mutation was detected in all SM patients but in only 2 patients with MMAS (range: 0.007-9% mutated cells). Basic tryptase elevation was demonstrated in 16/19 patients with SM but also in 9/19 patients without SM. Our study reveals the heterogeneity of primary MC disorders and the importance of sensitive assays in patients suspected of having SM.

  18. Cross-sectional study on respiratory effect of toner-exposed work in manufacturing plants, Japan: pulmonary function, blood cells, and biochemical markers.

    Science.gov (United States)

    Kitamura, H; Terunuma, N; Kurosaki, S; Hata, K; Ide, R; Kuga, H; Kakiuchi, N; Masuda, M; Totsuzaki, T; Osato, A; Uchino, B; Kitahara, K; Iwasaki, A; Yoshizumi, K; Morimoto, Y; Kasai, H; Murase, T; Higashi, T

    2009-06-01

    The aim of the study is to examine the relationship between toner-exposed work and health indices related to respiratory disorders and to confirm the baseline of a cohort study to clarify the effect of toner exposure in manufacturing plants. Subjects were 1614 male workers (809 toner-exposed workers and 805 referents) who were engaged in toner manufacturing plants in Japan (Fuji Xerox Co., Ltd). The age of subjects was from 19 to 59 years, and the average age was 40.2 years(median 40 years, SD 7.67). We conducted a pulmonary function test (PEFR, VC, FVC, FEV(1.0)%, V25/Ht) and a blood cell test (RBC, Hb, Hct, Plt, WBC, cell contents of WBC) and measured biochemical indices in blood (ALT, AST, gamma-GTP, CRP, IgE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine. Student t-test and logistic regression analysis were applied to compare between the toner-exposed workers and the referents and to analyze the relationship among indices of effects and independent factors. There was no significant difference between the two groups in blood cell count and biochemical indices. Inflammation- and allergy-related markers such as 8OHdG and IgE also showed no significant difference between toner-exposed workers and the referents. The influence of smoking on pulmonary function indices was observed, but there was no relationship between the pulmonary function and toner-exposed work. In this article, we report a preliminary cross-sectional analysis in the subjects of a cohort study. No difference in pulmonary function indices was observed between the toner-exposed workers and the referents, and there was no consistent relationship between the exposure status and examined indices; however, the prevalence of subjective respiratory symptoms was higher in the exposed workers as presented in another report. Further analysis is important in the ongoing cohort study to clarify the effect of toner exposure on respiratory systems.

  19. Developmental Work

    DEFF Research Database (Denmark)

    Møller, Niels; Hvid, Helge; Kristensen, Tage Søndergaard

    2003-01-01

    Human Deveoplment and Working Life - Work for Welfare explores whether the development of human resources at company level can improve individuals' quality of life, companies' possibilities of development, and welfare and democracy in society. Chapter two discuss the concept "developmental work......" from theoretical and empirical perspectives....

  20. Work Experience and Work Involvement.

    Science.gov (United States)

    Lorence, Jon; Mortimer, Jeylan T.

    1981-01-01

    Examines the interrelations of work experience and psychological involvement in work among male college graduates over a 10-year period. Both the occupational socialization and the occupational selection hypotheses are supported by the data analysis. (Author/JOW)

  1. [Reduced-intensity conditioning haematopoietic stem cell transplantation in genetic diseases: Experience of the Spanish Working Group for Bone Marrow Transplantation in Children].

    Science.gov (United States)

    López-Granados, Lucía; Torrent, Montserrat; Sastre, Ana; Gonzalez-Vicent, Marta; Díaz de Heredia, Cristina; Argilés, Bienvenida; Pascual, Antonia; Pérez-Hurtado, José M; Sisinni, Luisa; Diaz, Miguel Ángel; Elorza, Izaskun; Dasí, M Angeles; Badell, Isabel

    2017-07-07

    Haematopoietic stem cell transplantation (HSCT) involves implanting cellular elements capable of generating a new and healthy haematopoietic system. Reduced intensity conditioning (RIC) consists of an immunosuppressive treatment to facilitate a progressive implant with lower morbidity. This type of conditioning can also lead to myelosuppression, which is potentially reversible over time. Reduced intensity conditioning enables HSCT to be performed on patients with genetic diseases for whom added comorbidity is undesirable due to the high doses of chemotherapy that accompanies conventional myeloablative regimens. An analysis was performed on the outcomes of 68 paediatric patients with genetic diseases who underwent HSCT with RIC between 2005 and 2013 in the of Paediatric Haematopoietic Stem Cell Transplantation Units that are part of the Spanish Working Group for Bone Marrow Transplantation in Children. A multicentre study was conducted including 68 patients, of whom 43 had Primary Immunodeficiency, 21 with congenital haematological diseases, and 4 with metabolic diseases. Fifty (73.5%) of the 68 patients were still alive. The Overall Survival (OS) at nine years was 0.74. Twenty-three (33.8%) had some event during the course of the HSCT, with an event-free survival rate of 0.66. The OS in patients with haematological diseases was 0.81, being 0.7 in primary immunodeficiencies, and 0.4 in metabolic diseases. No significant difference was observed between the 3 groups of diseases. As regards the source of haematopoietic progenitors, there was an OS rate of 0.74 in patients transplanted with peripheral blood, 0.70 with bone marrow, and 0.70 and with cord blood, with no statistically significant differences. Favourable results have been obtained in HSCT with reduced intensity conditioning in genetic diseases. It should be noted that the risks and benefits of the RIC in patients with metabolic diseases need to be assessed on an individual basis. Copyright © 2017

  2. Low Work-function Poly(3,4-ethylenedioxylenethiophene): Poly(styrene sulfonate) as Electron-transport Layer for High-efficient and Stable Polymer Solar Cells

    Science.gov (United States)

    Zhang, Yong; Chen, Lie; Hu, Xiaotian; Zhang, Lin; Chen, Yiwang

    2015-08-01

    Low-work-function poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) modified with polyethylenimine (PEIE) was used as an electron transport layer (ETL) for polymer solar cells (PSCs). A thin layer of PEIE film was spin-coated onto the surface on the PEDOT:PSS films, thus substantially changing their charge selectivity from supporting hole transport to supporting electron transport. It was also found that the PEDOT:PSS/PEIE ETL exhibited higher interfacial contact, a more favorable active morphology, and improved charge mobility. By virtue of these beneficial properties, inverted PSCs based on low-bandgap semiconducting photoactive layers achieved a notably improved power conversion efficiency (PCE) of 7.94%, superior even to the corresponding performance of devices with only a ZnO layer. Surpassing our expectations, compared with the extreme degradation of device stability observed when pure PEDOT:PSS is used, PEIE-modified PEDOT:PSS can considerably suppress device degradation because of the hydrophobic and alkaline nature of PEIE, which not only reduces the hygroscopicity of the PEDOT:PSS but also neutralizes the acidic PEDOT:PSS and thus prevents the corrosion of the ITO cathode. These results demonstrate the potential of PEIE-modified PEDOT:PSS for use as an efficient ETL in commercial printed electronic devices.

  3. High-efficiency inverted polymer solar cells with transparent and work-function tunable MoO{sub 3}-Al composite film as cathode buffer layer

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jian; Fang, Gang [Graduate School of the Chinese Academy of Sciences, Beijing (China); Shao, Shuyan; Meng, Bin; Xie, Zhiyuan; Wang, Lixiang [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun (China)

    2012-05-22

    High-efficiency inverted polymer solar cells based on PCDTBT:PC{sub 70}BM blend with the MoO{sub 3}-Al composite film as the cathode buffer layer and the MoO{sub 3}/Al as the anode have been demonstrated. A V{sub OC} of 0.88 V, a J{sub SC} of 10.88 mA cm{sup -2}, a FF of 70.7% and a PCE of 6.77% are achieved. The MoO{sub 3}-Al composite films are highly transparent with adjustable work functions which can be fine tuned based on the Al content in the composite, thus allowing us to optimize the interfacial property at cathode buffer layer/BHJ interfaces to reduce recombination loss and to improve the photovoltaic performance. This new approach has simplified the device fabrication and will render economizing in large scale applications. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Projects Work!

    Science.gov (United States)

    Textor, Martin R.

    2005-01-01

    The great educational value of projects is emphasized by contrasting negative aspects of the life of today's children with the goals of project work. This is illustrated by a project "Shopping." It is shown what children are learning in such projects and what the advantages of project work are. Relevant topic areas, criteria for selecting a…

  5. Sedentary work

    DEFF Research Database (Denmark)

    Eriksen, Dorte; Rosthøj, Susanne; Burr, Hermann

    2015-01-01

    OBJECTIVE: The aim of this study is to investigate the association between five-year changes in occupational sitting and body mass index (BMI) in working adults. METHODS: We analyzed data from The Danish Work Environment Cohort Study (2005 and 2010, n=3.482). Data on occupational sitting, weight...

  6. Case work

    DEFF Research Database (Denmark)

    Shaw, Ian Frank

    2016-01-01

    Answers to the question just what is the ?case? partly defined the fields of sociology and social work in early 20th century Chicago. Drawing on the archives of the University of Chicago, I describe and appraise the way the ?case? figured in social work at Chicago and elsewhere. I ask...

  7. Work Stress

    OpenAIRE

    Roeters, Anne

    2014-01-01

    Most of us agree that stress is a growing problem within organizations. We hear about the postal workers who had killed fellow employees and supervisors, and then hear that a major cause of tension is at work. Friends tell us that they are stressed due to increased workload and he has to work overtime because the company is restructured. We read the polls that employees complain about the stress in trying to balance family life with the work. Stress is a dynamic condition in which an individu...

  8. Stereotactic body radiotherapy for renal cell cancer and pancreatic cancer. Literature review and practice recommendations of the DEGRO Working Group on Stereotactic Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Panje, Cedric; Andratschke, Nikolaus; Guckenberger, Matthias [Zurich University Hospital, Department of Radiation Oncology, Zurich (Switzerland); Brunner, Thomas B. [Freiburg University Hospital, Department of Radiation Oncology, Freiburg (Germany); Niyazi, Maximilian [University of Munich, Department of Radiation Oncology, Munich (Germany)

    2016-12-15

    This report of the Working Group on Stereotactic Radiotherapy of the German Society of Radiation Oncology (DEGRO) aims to provide a literature review and practice recommendations for stereotactic body radiotherapy (SBRT) of primary renal cell cancer and primary pancreatic cancer. A literature search on SBRT for both renal cancer and pancreatic cancer was performed with focus on prospective trials and technical aspects for clinical implementation. Data on renal and pancreatic SBRT are limited, but show promising rates of local control for both treatment sites. For pancreatic cancer, fractionated SBRT should be preferred to single-dose treatment to reduce the risk of gastrointestinal toxicity. Motion-compensation strategies and image guidance are paramount for safe SBRT delivery in both tumor entities. SBRT for renal cancer and pancreatic cancer have been successfully evaluated in phase I and phase II trials. Pancreatic SBRT should be practiced carefully and only within prospective protocols due to the risk of severe gastrointestinal toxicity. SBRT for primary renal cell cancer appears a viable option for medically inoperable patients but future research needs to better define patient selection criteria and the detailed practice of SBRT. (orig.) [German] Die Arbeitsgruppe ''Stereotaktische Radiotherapie'' der Deutschen Gesellschaft fuer Radioonkologie (DEGRO) legt eine Zusammenfassung der aktuellen Literatur und daraus resultierende Empfehlungen zur Durchfuehrung der stereotaktischen Strahlentherapie (SBRT) beim Nierenzellkarzinom und beim Pankreaskarzinom vor. Es erfolgte eine Literaturrecherche zur Evidenz der SBRT beim Nierenzell- und Pankreaskarzinom, wobei der Schwerpunkt auf prospektive Studien und technische Aspekte fuer die klinische Umsetzung gelegt wurde. Fuer die SBRT beim Pankreaskarzinom und Nierenzellkarzinom sind bisher nur wenige Studien veroeffentlicht worden, die jedoch konsistent eine hohe Rate an lokaler Tumorkontrolle

  9. Should PET/CT be implemented in the routine imaging work-up of locally advanced head and neck squamous cell carcinoma? A prospective analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cacicedo, Jon; Bilbao, Pedro [Cruces University Hospital, Radiation Oncology Department, Barakaldo, Bizkaia (Basque Country) (Spain); BioCruces Health Research Institute, Bizkaia, Basque Country (Spain); Fernandez, Iratxe [Cruces University Hospital, Nuclear Medicine Department, Barakaldo (Spain); Hoyo, Olga del; Hortelano, Eduardo [Cruces University Hospital, Radiation Oncology Department, Barakaldo, Bizkaia (Basque Country) (Spain); Dolado, Ainara [Cruces University Hospital, Radiodiagnostic and Medical Imaging Department, Barakaldo (Spain); Gomez-Suarez, Javier [Cruces University Hospital, Otolaryngology Department, Barakaldo (Spain); Sancho, Aintzane [Cruces University Hospital, Medical Oncology Department, Barakaldo (Spain); Pijoan, Jose I. [BioCruces Health Research Institute, Bizkaia, Basque Country (Spain); Cruces University Hospital, Clinical Epidemiology Unit, Barakaldo (Spain); CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid (Spain); Alvarez, Julio [Cruces University Hospital, Oral and Maxillofacial Surgery Department, Barakaldo (Spain); Espinosa, Jose M. [Cruces University Hospital, Medical Physics Department, Barakaldo (Spain); Gaafar, Ayman [Cruces University Hospital, Department of Pathology, Barakaldo (Spain)

    2015-08-15

    The objective of this study was to determine the incremental staging information provided by positron emission tomography/computed tomography (PET/CT) and its impact on management plans in patients with untreated stage III-IV head and neck squamous cell carcinoma (HNSCC). We prospectively studied, between September 2011 and February 2013, 84 consecutive patients [median age 63.5 years (39-84); 73 men] with histologically confirmed HNSCC. First, based on a conventional work-up (physical examination, CT imaging of the head, neck and chest), the multidisciplinary Head and Neck Tumour Board documented the TNM stage and a management plan for each patient, outlining the modalities to be used, including surgery, radiation therapy (RT), chemotherapy or a combination. After release of the PET/CT results, new TNM staging and management plans were agreed on by the multidisciplinary Tumour Board. Any changes in stage or intended management due to the PET/CT findings were then analysed. The impact on patient management was classified as: low (treatment modality, delivery and intent unchanged), moderate (change within the same treatment modality: type of surgery, radiation technique/dose) or high (change in treatment intent and/or treatment modality → curative to palliative, or surgery to chemoradiation or detection of unknown primary tumour or a synchronous second primary tumour). TNM stage was validated by histopathological analysis, additional imaging or follow-up. Accuracy of the conventional and PET/CT-based staging was compared using McNemar's test. Conventional and PET/CT stages were discordant in 32/84 (38 %) cases: the T stage in 2/32 (6.2 %), the N stage in 21/32 (65.7 %) and the M stage 9/32 (28.1 %). Patient management was altered in 22/84 (26 %) patients, with a moderate impact in 8 (9.5 %) patients and high impact in 14 (16.6 %) patients. PET/CT TNM classification was significantly more accurate (92.5 vs 73.7 %) than conventional staging with a p value < 0

  10. Does "Social Work Abstracts" Work?

    Science.gov (United States)

    Holden, Gary; Barker, Kathleen; Covert-Vail, Lucinda; Rosenberg, Gary; Cohen, Stephanie A.

    2008-01-01

    Objective: The current study seeks to provide estimates of the adequacy of journal coverage in the Social Work Abstracts (SWA) database. Method: A total of 23 journals listed in the Journal Citation Reports social work category during the 1997 to 2005 period were selected for study. Issue-level coverage estimates were obtained for SWA and…

  11. Working Collaboratively

    DEFF Research Database (Denmark)

    Holder, Anna; Lovett, George

    2009-01-01

    identified as a transformative global force of the last decade, most notably in knowledge and information publishing, communication and creation. This paper presents a structured conversation on changing understandings of collaboration, and the realities of collaborative methodology in architectural work....... Ideas of the platforms and structures necessary to support ‘creative’ collaborations are advanced and tested, and a vocabulary of key terms is developed. The conversation extends to reflect on the role of the architecture profession in supporting or enabling collaboration in architectural works....

  12. Construction work

    CERN Multimedia

    2004-01-01

    Construction work on building 179 will start on the 16th February 2004 and continue until November 2004. The road between buildings 179 and 158 will temporarily become a one way street from Route Democrite towards building 7. The parking places between buildings 179 and 7 will become obsolete. The ISOLDE collaboration would like to apologize for any inconveniences.

  13. Heart Work

    Science.gov (United States)

    Madden, Sandra R.; Gonzales, Alicia C.

    2017-01-01

    It is not every day that a former student greets a teacher with, "Your course changed my life." The authors are the professor and student of the transformative course. Alicia Gonzales wanted to understand how to work with students to co-construct an environment where persistent problem solving in a technologically rich classroom was the…

  14. Road works

    CERN Multimedia

    GS Department

    2010-01-01

    From Monday 11 October until Friday 29 October 2010, the flow of traffic will be disrupted by road works at the roundabout in front of Restaurant No. 2; The number of spaces available in the car park in front of Rest. No. 2 will be reduced. Thank you for your understanding during this period. GS/SEM Group

  15. Demolition work

    CERN Multimedia

    2004-01-01

    Because of demolition work inside Bldg. 251, two containers will be placed on the route Démocrite. For security reasons, the part of this road in front of barrack 553 will be closed to circulation from 5 to 12 November. Thank you, in advance for your understanding. PH-SMI

  16. Wetlands Work

    Science.gov (United States)

    Messina, Linda; Blanchard, Pamela Borne

    2004-01-01

    This article describes how a biology teacher's search for a cross-curricular project in science, math, history, and environmental science, that would help her students connect what they were learning in the classroom to their everyday life, resulted in an ongoing stewardship project. Working together with the Louisiana Sea Grant College Program…

  17. The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.

    Science.gov (United States)

    Brabin, Charles; Appleford, Peter J; Woollard, Alison

    2011-08-01

    Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 expression is directly regulated by the GATA factor ELT-1. elt-1(RNAi) animals display similar seam cell lineage defects to bro-1 mutants, but have an additional phenotype in which seam cells lose their stem cell-like properties and differentiate inappropriately by fusing with the hyp7 epidermal syncytium. This phenotype is dependent on the fusogen EFF-1, which we show is repressed by ELT-1 in seam cells. Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation.

  18. Whole-body-MR imaging including DWIBS in the work-up of patients with head and neck squamous cell carcinoma: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Noij, Daniel P., E-mail: d.noij@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Boerhout, Els J., E-mail: e.boerhout@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Pieters-van den Bos, Indra C., E-mail: i.pieters@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Comans, Emile F., E-mail: efi.comans@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Oprea-Lager, Daniela, E-mail: d.oprea-lager@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Reinhard, Rinze, E-mail: r.reinhard@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Hoekstra, Otto S., E-mail: os.hoekstra@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Bree, Remco de, E-mail: r.debree@vumc.nl [Department Otolaryngology/Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Graaf, Pim de, E-mail: p.degraaf@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands); Castelijns, Jonas A., E-mail: j.castelijns@vumc.nl [Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam (Netherlands)

    2014-07-15

    Objectives: To assess the feasibility of whole-body magnetic resonance imaging (WB-MRI) including diffusion-weighted whole-body imaging with background-body-signal-suppression (DWIBS) for the evaluation of distant malignancies in head and neck squamous cell carcinoma (HNSCC); and to compare WB-MRI findings with {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F-FDG-PET/CT) and chest-CT. Methods: Thirty-three patients with high risk for metastatic spread (26 males; range 48–79 years, mean age 63 ± 7.9 years (mean ± standard deviation) years) were prospectively included with a follow-up of six months. WB-MRI protocol included short-TI inversion recovery and T1-weighted sequences in the coronal plane and half-fourier acquisition single-shot turbo spin-echo T2 and contrast-enhanced-T1-weighted sequences in the axial plane. Axial DWIBS was reformatted in the coronal plane. Interobserver variability was assessed using weighted kappa and the proportion specific agreement (PA). Results: Two second primary tumors and one metastasis were detected on WB-MRI. WB-MRI yielded seven clinically indeterminate lesions which did not progress at follow-up. The metastasis and one second primary tumor were found when combining {sup 18}F-FDG-PET/CT and chest-CT findings. Interobserver variability for WB-MRI was κ = 0.91 with PA ranging from 0.82 to 1.00. For {sup 18}F-FDG-PET/CT κ could not be calculated due to a constant variable in the table and PA ranged from 0.40 to 0.99. Conclusions: Our WB-MRI protocol with DWIBS is feasible in the work-up of HNSCC patients for detection and characterization of distant pathology. WB-MRI can be complementary to {sup 18}F-FDG-PET/CT, especially in the detection of non {sup 18}F-FDG avid second primary tumors.

  19. Standardization work

    Science.gov (United States)

    Malavallon, Olivier

    1995-04-01

    For several years now, the main civil aircraft manufacturers (Airbus and its partners, Boeing, Fokker, McDonnell Douglas) have been working jointly on the writing of technical recommendations and the drawing up of an international standard. This work concerns the evaluation of the processes and products used to strip aeronautical paint systems. This procedure was initiated on request from the main airlines. In effect, the airlines are faced with situations in which the financial and operational objectives are becoming increasingly important. The need was felt to rationalize and, if possible, harmonize the criteria and technical requirements of the various civil aircraft manufacturers in order to facilitate in-service maintenance of the fleets of airlines operating Airbus, Boeing, Douglas aircraft, etc.

  20. Working memory.

    Science.gov (United States)

    Baddeley, A

    1992-01-31

    The term working memory refers to a brain system that provides temporary storage and manipulation of the information necessary for such complex cognitive tasks as language comprehension, learning, and reasoning. This definition has evolved from the concept of a unitary short-term memory system. Working memory has been found to require the simultaneous storage and processing of information. It can be divided into the following three subcomponents: (i) the central executive, which is assumed to be an attentional-controlling system, is important in skills such as chess playing and is particularly susceptible to the effects of Alzheimer's disease; and two slave systems, namely (ii) the visuospatial sketch pad, which manipulates visual images and (iii) the phonological loop, which stores and rehearses speech-based information and is necessary for the acquisition of both native and second-language vocabulary.

  1. Works notice

    CERN Multimedia

    GS Department

    2009-01-01

    We would like to inform you that renovation work on the road lighting equipment will take place on the Meyrin site between 19 October and 18 December 2009. During this period, traffic will be disrupted on the Schrödinger, Perrin and Siegbahn roads, ie from Building 274 to Building 188. We request that you comply with the road signs and thank you for your understanding. GS-SEM Group

  2. RESUMING WORK

    CERN Multimedia

    Medical Service

    2002-01-01

    In application of the Staff Rules and Regulations, every member of the CERN personnel is required to undergo a medical examination on resuming work after sick leave: if the medical absence has been for 21 calendar days or longer, if absent more than 48 hours due to professional accident. It is incumbent upon the member of the personnel himself/herself to contact the Medical Service 73186, without awaiting its summons. Medical Service

  3. RESUMING WORK

    CERN Multimedia

    Medical Service

    2001-01-01

    In application of the Staff Rules and Regulations, every member of the CERN personnel is required to undergo a medical examination on resuming work after sick leave: if the medical absence has been for 21 calendar days or longer, if absent more than 48 hours due to professional accident. It is incumbent upon the member of the personnel himself/herself to contact the Medical Service 73186, without awaiting its summons.

  4. Paid work and unpaid work

    DEFF Research Database (Denmark)

    Bonke, Jens

    Time-use information is preferably obtained from diaries, as this method is considered more reliable than information from questionnaires. The diary-technique seems to be unique in catching the rhythm of every day life and thereby the structuring of work and leisure during a well-defined and memo...

  5. RESUMING WORK

    CERN Multimedia

    2003-01-01

    In application of the Staff Rules and Regulations, every member of the CERN personnel is required to undergo a medical examination on resuming work after sick leave: - if the medical absence has been for 21 calendar days or longer - if absent more than 48 hours due to professional accident It is incumbent upon the member of the personnel himself/herself to contact the Medical Service Tel. 73186, without awaiting its summons. The purpose of this exam is not to check on the absenteeism, but to support the professional reinsertion. Medical Service

  6. RESUMING WORK

    CERN Document Server

    2004-01-01

    In application of the Staff Rules and Regulations, every member of the CERN personnel is required to undergo a medical examination on resuming work after sick leave: • if the medical absence has been for 21 calendar days or longer • if absent more than 48 hours due to professional accident It is incumbent upon the member of the personnel himself/herself to contact the Medical Service tel. 73186, without awaiting its summons. The purpose of this exam is not to check on the absenteeism, but to support the professional reinsertion. Medical Service

  7. RESUMING WORK

    CERN Document Server

    2003-01-01

    In application of the Staff Rules and Regulations, every member of the CERN personnel is required to undergo a medical examination on resuming work after sick leave: - if the medical absence has been for 21 calendar days or longer - if absent more than 48 hours due to professional accident It is incumbent upon the member of the personnel himself/herself to contact the Medical Service tel. 73186, without awaiting its summons. The purpose of this exam is not to check on the absenteeism, but to support the professional reinsertion. Medical Service

  8. Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years

    Directory of Open Access Journals (Sweden)

    Eric Domingos Mariano

    2014-06-01

    Full Text Available Spinal cord injury (SCI and amyotrophic laterals sclerosis (ALS are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective : The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method : Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion : The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.

  9. Allogeneic stem-cell transplantation in patients with Waldenstrom macroglobulinemia: report from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.

    NARCIS (Netherlands)

    Kyriakou, C.; Canals, C.; Cornelissen, J.J.; Socie, G.; Willemze, R.; Ifrah, N.; Greinix, H.T.; Blaise, D.; Deconinck, E.; Ferrant, A.; Schattenberg, A.V.M.B.; Harousseau, J.L.; Sureda, A.; Schmitz, N.

    2010-01-01

    PURPOSE: Allogeneic stem-cell transplantation (alloSCT) is a curative therapeutic option for patients with low-grade lymphoid malignancies. Information regarding alloSCT in Waldenstrom macroglobulinemia (WM) is limited. This study presents the long-term outcome of a large series of patients with WM

  10. EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1.

    Directory of Open Access Journals (Sweden)

    Miguel Sáinz-Jaspeado

    Full Text Available Angiogenesis is the result of the combined activity of the tumor microenvironment and signaling molecules. The angiogenic switch is represented as an imbalance between pro- and anti-angiogenic factors and is a rate-limiting step in the development of tumors. Eph receptor tyrosine kinases and their membrane-anchored ligands, known as ephrins, constitute the largest receptor tyrosine kinase (RTK subfamily and are considered a major family of pro-angiogenic RTKs. Ewing sarcoma (EWS is a highly aggressive bone and soft tissue tumor affecting children and young adults. As other solid tumors, EWS are reliant on a functional vascular network for the delivery of nutrients and oxygen and for the removal of waste. Based on the biological roles of EphA2 in promoting angiogenesis, we explored the functional role of this receptor and its relationship with caveolin-1 (CAV1 in EWS angiogenesis. We demonstrated that lack of CAV1 results in a significant reduction in micro vascular density (MVD on 3 different in vivo models. In vitro, this phenomenon correlated with inactivation of EphA2 receptor, lack of AKT response and downregulation of bFGF. We also demonstrated that secreted bFGF from EWS cells acted as chemoattractant for endothelial cells. Furthermore, interaction between EphA2 and CAV1 was necessary for the right localization and signaling of the receptor to produce bFGF through AKT and promote migration of endothelial cells. Finally, introduction of a dominant-negative form of EphA2 into EWS cells mostly reproduced the effects occurred by CAV1 silencing, strongly suggesting that the axis EphA2-CAV1 participates in the promotion of endothelial cell migration toward the tumors favoring EWS angiogenesis.

  11. [Peripheral stem cell collection, search for predictive factors: a multicenter study. Working Group on Transfusion and Therapeutic Techniques of the French Blood Transfusion Society ].

    Science.gov (United States)

    Clément, A; Coffe, C; Adjizian, J C; Villard, F; Jolly, D; Desbois, I; Léon, A

    2000-10-01

    A multicentric study involving 12 centers was made to investigate the results of peripheral stem cell collection carried out between 1996 and 1997 from 655 patients with hemopathic syndromes or malignant tumors, The aim of this investigation was to determine the predictive factors for transplant quality, and to thereby optimize collection procedures. Information sheets were completed for 1,346 cytapheretic sessions, i.e., 655 grafts. The samples were taken after induction chemotherapy and exposure to hematopoeitic colony-stimulating growth factors (except the LMCs). Each graft was defined as being of good or bad quality depending on the number of CD34+ cells that it contained. Based on the data available in the literature, a workgroup consensus was reached that a level of CD34+ cells +/- 2.10(6)/kg recipient body weight constituted a good transplant criterion. The 2 subgroups (good graft versus lower quality graft) were compared by univariate analysis followed by discriminant multivariate analysis. It was established that a number of parameters were significantly linked to the criterion of collection quality; however, 3 predictive factors emerged from the multivariate analysis--the level of circulating CD34+ cells; the number of cytaphereses; the number of blood volumes treated. It was concluded that the level of circulating CD34+ cells seems to be an essential aspect in predicting the quality of the transplant and the number of cytaphereses required to obtain a sufficiently rich collection. Moreover, it also appears that at least 2 blood volumes should be treated to optimize the results.

  12. Creativity and Innovation in the Context of Team-work: an Evaluation in the Self-management Cells and Quality Control Circles of Ambev S.C. Branch

    Directory of Open Access Journals (Sweden)

    Valeska Nahas Guimarães

    2007-01-01

    Full Text Available This paper is about changes in the business world. The main goal is to study the implications related to people’s creativity expression owing to work organization in small groups in the Ambev S.C. branch. This is a qualitative study based on a case study. 21 self-management circles and 18 quality control circles in the organization were found. The self management circles are responsible for achieving the organizational main goals and the quality control circles to bring best practices and new ideas. The result shows that quality control circles are more powerful than the self management circles as a space to develop people creativity and organizational innovation. It is relevant to stress that in the CCQs there are more multidisciplinary and common purpose guided to a collective objective desired by all the members of the team. On the other hand, in the CGA´s there are more discipline to accept the common tactics to people reach the objectives of the group and the corporative aims. The conclusion is that the changes in the business environment make the small work group very important to a company’s creativity and a fundamental strategy differentiation in the process of work organization in the context of the business world.

  13. Work team

    Directory of Open Access Journals (Sweden)

    RBE Editorial

    2016-06-01

    Full Text Available Work Team 2016 (Jan-Jul1. Editorial TeamChief-editorsBayardo Bapstista Torres, Instituto de Química (USP, BrasilEduardo Galembeck, Depto. Bioquímica, Instituto de Biologia, Universidade de Campinas (Unicamp, Brasil Co-editorsGabriel Gerber Hornink, Depto. Bioquímica, Instituto de Ciências Biomédicas, Universidade - Federal de Alfenas (Unifal-MG, BrasilVera Maria Treis Trindade, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS, Brasil Editorial BoardAdriana Cassina, Department of Biochemistry, Facultad de Medicina, Universidad de la República, UruguayAngel Herráez, Departamento de Bioquímica y Biología molecular, Universidad de Alcalá de Henares, Madrid, SpainAndré Amaral Gonçalves Bianco, Universidade Federal de São Paulo (Unifesp, BrasilDenise Vaz de Macedo, Depto. Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp, BrasilEneida de Paula, Depto. Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp, BrasilJose Antonio Martinez Oyanedel, Universidad de Concepción, ChileJosep Maria Fernández Novell, Department of Molecular Biology & Biochemistry, Universitat de Barcelona, SpainLeila Maria Beltramini, Instituto de Física de São Carlos, Universidade Estadual de São Paulo (USP, BrasilManuel João da Costa, Escola de Ciências da Saúde, Universidade do Minho, PortugalMaria Lucia Bianconi, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro (UFRJ, BrasilMaría Noel Alvarez, Department of Biochemistry, Facultad de Medicina, Universidad de la República, UruguayMiguel Ángel Medina Torres, Department of Molecular Biology & Biochemistry Faculty of Sciences University of Málaga, SpainNelma Regina Segnini Bossolan, Instituto de Física de São Carlos, Universidade de São Paulo (USP, BrasilPaulo De Avila Junior, Centro de Ciências Naturais e Humanas (CCNH Universidade Federal do ABC (UFABC

  14. Creativity and innovation in the context of team-work: an evaluation in the self-management cells and quality control circles of Ambev S.C. Branch

    OpenAIRE

    Valeska Nahas Guimarães; Felipe de Faria Monaco

    2007-01-01

    This paper is about changes in the business world. The main goal is to study the implications related to people's creativity expression owing to work organization in small groups in the Ambev S.C. branch. This is a qualitative study based on a case study. 21 self-management circles and 18 quality control circles in the organization were found. The self management circles are responsible for achieving the organizational main goals and the quality control circles to bring best practices and new...

  15. Development of A Novel Methode for COD (Chemical Oxygen Demand Measurement based onPhotoelectrochemical Cell: Characterization of TiO2/ITO Film Working Electrode

    Directory of Open Access Journals (Sweden)

    Y.K. Krisnandi

    2009-04-01

    Full Text Available Nanosize TiO2 film,immobilized on an ITO (Indium Tin Oxide glass, was successfully fabricated. The film was prepared by a dip coatingtechnique in a hydrothermal sol-gel system and subjected to a heat treatment at 100°C up to 450°C. Characterization ofthe film by XRD, AFM, BET methods revealed the occurrence of anatase form and 9.64 nm in crystallite size; havingthree dimensional profile and roughness with height of typically 9.8 nm; and surface area of 58.21 m2/g. The film thenwas employed as a working electrode in a photo electrochemical system (PES. This PES generated a photocurrent thatproportional to the organic chemical concentration in the water sample. Integration of the photocurrent versus timegives a charge (Q that represent the event of complete mineralization of organic chemical in the TiO2 surface and canbe correlated to the Chemical Oxygen Demand (COD of measured water. This system has a potential to be developedfor a novel COD sensor.

  16. Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population-based case-control study FB-181.

    Science.gov (United States)

    Schmitt, J; Haufe, E; Trautmann, F; Schulze, H-J; Elsner, P; Drexler, H; Bauer, A; Letzel, S; John, S M; Fartasch, M; Brüning, T; Seidler, A; Dugas-Breit, S; Gina, M; Weistenhöfer, W; Bachmann, K; Bruhn, I; Lang, B M; Bonness, S; Allam, J P; Grobe, W; Stange, T; Westerhausen, S; Knuschke, P; Wittlich, M; Diepgen, T L

    2017-08-27

    Squamous cell carcinoma (SCC) is one of the most frequent types of cancer constituting a significant public health burden. Prevention strategies focus on limiting ultraviolet (UV) exposure during leisure time. However, the relative impact of occupational and nonoccupational UV exposure for SCC occurrence is unclear. To investigate the association between occupational and nonoccupational UV exposure for SCC in a multicentre population-based case-control study hypothesizing that high occupational UV exposure increases the risk of SCC. Consecutive patients with incident SCC (n = 632) were recruited from a German national dermatology network. Population-based controls (n = 996) without history of skin cancer were recruited from corresponding residents' registration offices and propensity score matched to cases. Lifetime UV exposure, sociodemographic and clinical characteristics were assessed by trained physicians. Occupational and nonoccupational UV exposure doses were estimated by masked investigators using established reference values. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were assessed using conditional logistic regression adjusting for relevant confounders. Total solar UV exposure was significantly associated with increased SCC. The OR for high (> 90th percentile) vs. low (percentile) and high vs, moderate (40-59th percentile) occupational UV exposure was 1·95 (95% CI 1·19-3·18) and 2·44 (95% CI 1·47-4·06) for SCC. Adjusting for occupational UV exposure, nonoccupational UV exposure was not significantly related to SCC incidence. Dose-response relationships were observed for occupational but not for nonoccupational solar UV exposure. Solar occupational UV exposure is a major determinant of incident SCC. Our findings indicate that prevention strategies should be further expanded to the occupational setting. © 2017 British Association of Dermatologists.

  17. Meaningful work, work engagement and organisational commitment

    OpenAIRE

    Madelyn Geldenhuys; Karolina Łaba; Cornelia M. Venter

    2014-01-01

    Orientation: Meaningful work can yield benefits for organisations and lead to positive work outcomes such as satisfied, engaged and committed employees, individual and organisational fulfilment, productivity, retention and loyalty.Research purpose: The aim of the study was to investigate the relationships amongst psychological meaningfulness, work engagement and organisational commitment and to test for a possible mediation effect of work engagement on the relationship between psychological ...

  18. Meaningful work, work engagement and organisational commitment

    Directory of Open Access Journals (Sweden)

    Madelyn Geldenhuys

    2014-02-01

    Full Text Available Orientation: Meaningful work can yield benefits for organisations and lead to positive work outcomes such as satisfied, engaged and committed employees, individual and organisational fulfilment, productivity, retention and loyalty.Research purpose: The aim of the study was to investigate the relationships amongst psychological meaningfulness, work engagement and organisational commitment and to test for a possible mediation effect of work engagement on the relationship between psychological meaningfulness and organisational commitment.Motivation for the study: Managers have to rethink ways of improving productivity and performance at work, due to the diverse, and in some instances escalating, needs of employees (e.g. financial support to uphold their interest in and enjoyment of working.Research approach, design and method: A quantitative approach was employed to gather the data for the study, utilising a cross-sectional survey design. The sample (n = 415 consisted of working employees from various companies and positions in Gauteng, South Africa.Main findings: The results confirmed a positive relationship between psychological meaningfulness, work engagement and organisational commitment. Further, psychological meaningfulness predicts work engagement, whilst psychological meaningfulness and work engagement predict organisational commitment.Practical/managerial implications: Employers identifying their employees’ commitment patterns and mapping out strategies for enhancing those that are relevant to organisational goals will yield positive work outcomes (e.g. employees who are creative, seek growth or challenges for themselves.Contribution/value-add: This study contributes to the literature through highlighting the impact that meaningful work has on sustaining employee commitment to the organisation.

  19. New ways of working and work engagement

    NARCIS (Netherlands)

    Baudewijns, C.; Gerards, R.; de Grip, A.

    2015-01-01

    This article investigates whether New Ways of Working (NWW) are related to employee work engagement in the Netherlands. We test our hypotheses using a sample of 656 employees from 14 industry sectors and 12 occupational fields. Our study reveals that three facets of NWW positively affect work

  20. Passion for work: Work engagement versus workaholism.

    OpenAIRE

    Gorgievski-Duijvesteijn, Marjan; Bakker, Arnold

    2010-01-01

    textabstractIntroduction: Nothing great in the world has been accomplished without passion. Georg Wilhelm Friedrich Hegel (1770-1831) Is passion needed for excellent performance? The question of what predicts outstanding performance at work remains timely and relevant. The term “passion for work” emerged from qualitative research on entrepreneurs’ motivation, and has been defined as a selfish, passionate love for the work (Shane, Locke & Collins, 2003). Passion for work has been proposed as k...

  1. Dye···TiO{sub 2} Interfacial Structure of Dye-Sensitised Solar Cell Working Electrodes Buried under a Solution of I-/I{sub 3}- Redox Electrolyte

    Energy Technology Data Exchange (ETDEWEB)

    McCree-Grey, Jonathan; Cole, Jacqueline M.; Holt, Stephen A.; Evans, Peter J.; Gong, Yun

    2017-08-28

    Dye-sensitised solar cells (DSCs) have niche prospects for electricity-generating windows that could equip buildings for energy-sustainable future cities. However, this 'smart window' technology is being held back by a lack of understanding in how the dye interacts with its device environment at the molecular level. A better appreciation of the dye center dot center dot center dot TiO2 interfacial structure of the DSC working electrodes would be particularly valuable since associated structure-function relationships could be established; these rules would provide a 'toolkit' for the molecular engineering of more suitable DSC dyes via rational design. Previous materials characterisation efforts have been limited to determining this interfacial structure within an environment exposed to air or situated in a solvent medium. This study is the first to reveal the structure of this buried interface within the functional device environment, and represents the first application of in situ neutron reflectometry to DSC research. By incorporating the electrolyte into the structural model of this buried interface, we reveal how lithium cations from the electrolyte constituents influence the dye center dot center dot center dot TiO2 binding configuration of an organic sensitiser, MK-44, via Li+ complexation to the cyanoacrylate group. This dye is the molecular congener of the high-performance MK-2 DSC dye, whose hexa-alkyl chains appear to stabilise it from Li+ complexation. Our in situ neutron reflectometry findings are built up from auxiliary structural models derived from ex situ X-ray reflectometry and corroborated via density functional theory and UV/vis absorption spectroscopy. Significant differences between the in situ and ex situ dye center dot center dot center dot TiO2 interfacial structures are found, highlighting the need to characterise the molecular structure of DSC working electrodes while in a fully assembled device.

  2. Riding Third: Social Work in Ambulance Work

    Science.gov (United States)

    Campbell, Hilary; Rasmussen, Brian

    2012-01-01

    This research explored the possible role of social work alongside emergency ambulance services. An ethnographic study included semistructured interviews and direct observations collected over 300 hours while riding in ambulances in an urban setting. The data suggest that social work could play a role by providing needed psychosocial care during…

  3. Knowledge work and work-related stress

    DEFF Research Database (Denmark)

    Ipsen, Christine

    2006-01-01

    . These companies employ highly educated and com-petent people who apply their personal knowledge to generate new knowledge in close relationship with both custom-ers and colleagues. The employees are self-managed and work in networks and decentralised structures around pro-jects. Their working life is described...... tied to the employees. The opportunities are on the other more financially tangible in terms of increased efficiency, decreased sick-leave, extra time for new developments, less mistakes made, increased working capacity, quality, effi-ciency and productivity....

  4. Aspirin to Zoloft: Ways Medicines Work

    Science.gov (United States)

    ... View All Articles | Inside Life Science Home Page Aspirin to Zoloft: Ways Medicines Work By Emily Carlson ... biology of how cancer cells grow. Antihistamines, Antidepressants, Aspirin Adrenergic receptor with carazolol, a beta-blocker. View ...

  5. Balancing Machine Work, Comfort Work, and Sentimental Work

    DEFF Research Database (Denmark)

    Pedersen, Maria Ie; Hansen, Magnus; Hertzum, Morten

    2011-01-01

    To improve prehospital care ambulances carry increasingly sophisticated equipment aimed at initiating patient care already at the scene of injury. The competent use of this equipment is central to prehospital care but it also competes for increasing amounts of the ambulance crew’s time and attent......To improve prehospital care ambulances carry increasingly sophisticated equipment aimed at initiating patient care already at the scene of injury. The competent use of this equipment is central to prehospital care but it also competes for increasing amounts of the ambulance crew’s time...... and attention. We investigate ambulance care in three of Denmark’s five healthcare regions, which staff ambulances with emergency medical technicians, paramedics, and physicians. Using the concept of illness trajectory we analyse how the ambulance crews balance machine work, which involves continuously...... monitoring the equipment, comfort work, which is actions taken to relieve the pain or discomfort of the patient, and sentimental work, which is care for the patient’s physical and mental well-being, often verbal in nature. The analysis shows that comfort and sentimental work often takes priority over machine...

  6. Patterns of work injuries

    DEFF Research Database (Denmark)

    Lander, Flemming; Nielsen, Kent Jacob; Rasmussen, Kurt

    2014-01-01

    To compare work injuries treated in an emergency department (ED) and injuries reported to the Danish Working Environment Authority (DWEA).......To compare work injuries treated in an emergency department (ED) and injuries reported to the Danish Working Environment Authority (DWEA)....

  7. Struggling at work

    DEFF Research Database (Denmark)

    Hjarsbech, Pernille U; Nielsen, Maj Britt D.; Andersen, Malene Friis

    2015-01-01

    with problems at work. Methods: From a survey study on work and mental health in Denmark, we invited participants for in-depth interviews. Using grounded theory, we conducted 13 semi structured interviews with employees, at work, experiencing depressive symptoms. Findings: Work was pivotal for the informants...

  8. CTOs at work

    CERN Document Server

    Donaldson, Scott; Donaldson, Gary

    2012-01-01

    Scott Donaldson, Stanley Siegel and Gary Donaldson interview many of the world's most influential chief technology officers in CTOs at Work, offering a brand-new companion volume to the highly acclaimed elite At Work books including Coders at Work, CIOS at Work and Venture Capitalists at Work. As the words "at work" suggest, the authors focus on how their interviewees tackle the day-to-day work of the CTO while revealing much more: how they got there, how they manage and allocate projects, and how they interact with business units and ensure that their companies take advantage of technologies,

  9. Abstract: Body Work

    DEFF Research Database (Denmark)

    Otto, Lene

    2012-01-01

    This panel will explore the usefulness of the term ‘body work’ in cultural history. Body work is understood as work focusing on the bodies of others as component in a range of occupations in health and social care, as well as in unpaid work in the family. How can the notion of body work inform...... cultural history of health and illness whether through a micro-social focus on the intercorporeal aspects of work in health and social care, or through clarifying our understanding of the times and spaces of work, or through highlighting the relationship between mundane body work and global processes....... The British sociologist Julia Twigg has introduced and explored the term `bodywork', most recently in Body Work in Health and Social Care - Critical Themes, New Agendas (2011). She extends the term body work from applying to the work that individuals undertake on their own bodies, often as part of regimens...

  10. Live to work or love to work: work craving and work engagement.

    Science.gov (United States)

    Wojdylo, Kamila; Baumann, Nicola; Fischbach, Lis; Engeser, Stefan

    2014-01-01

    According to the theory of work craving, a workaholic has a craving for self-worth compensatory incentives and an expectation of relief from negative affect experienced through neurotic perfectionism and an obsessive-compulsive style of working. Research has shown that workaholism and work engagement should be considered as two distinct work styles with different health consequences. However, the mechanisms underlying the adoption of these work styles have been neglected. The present study proposes that work craving and work engagement are differentially associated with self-regulatory competencies and health. In particular, we expected that the working styles mediate the relationships between emotional self-regulation and health. In the cross-sectional study, 469 teachers from German schools completed online administered questionnaires. By means of structural equation modeling, we tested two indirect paths: a) from self-relaxation deficits via work craving to poor health and b) from self-motivation competencies via work engagement to good health. As expected, we found evidence that a) the negative relationship of self-relaxation deficits on health was partially mediated by work craving and b) the positive relationship of self-motivation competencies on health was partially mediated by work engagement. The present study emphasizes the importance of self-regulation competencies for healthy or unhealthy work styles. Whereas work craving was associated with a low ability to down-regulate negative emotions and poor health, work engagement was associated with a high ability to up-regulate positive emotions and good health.

  11. Anti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

    Science.gov (United States)

    Baron, Frédéric; Mohty, Mohamad; Blaise, Didier; Socié, Gérard; Labopin, Myriam; Esteve, Jordi; Ciceri, Fabio; Giebel, Sebastian; Gorin, Norbert Claude; Savani, Bipin N; Schmid, Christoph; Nagler, Arnon

    2017-02-01

    Allogeneic hematopoietic stem cell transplantation is increasingly used as treatment for patients with life-threatening blood diseases. Its curative potential is largely based on immune-mediated graft-versus-leukemia effects caused by donor T cells contained in the graft. Unfortunately, donor T cells are also the cause of graft-versus-host disease. The vast majority of human leukocyte antigen-matched allogeneic hematopoietic stem cell transplants are nowadays carried out with peripheral blood stem cells as the stem cell source. In comparison with bone marrows, peripheral blood stem cells contain more hematopoietic stem/progenitor cells but also one log more T cells. Consequently, the use of peripheral blood stem cells instead of bone marrow has been associated with faster hematologic recovery and a lower risk of relapse in patients with advanced disease, but also with a higher incidence of chronic graft-versus-host disease. These observations have been the basis for several studies aimed at assessing the impact of immunoregulation with anti-thymocyte globulin on transplantation outcomes in patients given human leukocyte antigen-matched peripheral blood stem cells from related or unrelated donors. After a brief introduction on anti-thymocyte globulin, this article reviews recent studies assessing the impact of anti-thymocyte globulin on transplantation outcomes in patients given peripheral blood stem cells from human leukocyte antigen-matched related or unrelated donors as well as in recipients of grafts from human leukocyte antigen haploidentical donors. Copyright© Ferrata Storti Foundation.

  12. Predicting Sustainable Work Behavior

    DEFF Research Database (Denmark)

    Hald, Kim Sundtoft

    2013-01-01

    . Employee characteristics and general attitudes towards safety and work condition are included in the extended model. A survey was handed out to 654 employees in Chinese factories. This research contributes by demonstrating how employee- characteristics and general attitudes towards safety and work...... condition influence their sustainable work behavior. A new definition of sustainable work behavior is proposed.......Sustainable work behavior is an important issue for operations managers – it has implications for most outcomes of OM. This research explores the antecedents of sustainable work behavior. It revisits and extends the sociotechnical model developed by Brown et al. (2000) on predicting safe behavior...

  13. The Ambiguity of Work

    DEFF Research Database (Denmark)

    Humle, Didde Maria

    2014-01-01

    This article contributes to the current debate among organizational and work-life researchers on the double-sided nature of knowledge work, which offers great freedom and satisfaction on the one hand and the potential to be overly demanding and stressful on the other. This contribution involves...... drawing on the results of an ethnographic case study of a consultancy house; more specifically, it comprises an exploration of the narrative identity work of consultants as they perform work practice stories of self, work, and the organization negotiating why the work they do is both challenging...

  14. Prediction of Allogeneic Hematopoietic Stem-Cell Transplantation Mortality 100 Days After Transplantation Using a Machine Learning Algorithm: A European Group for Blood and Marrow Transplantation Acute Leukemia Working Party Retrospective Data Mining Study.

    Science.gov (United States)

    Shouval, Roni; Labopin, Myriam; Bondi, Ori; Mishan-Shamay, Hila; Shimoni, Avichai; Ciceri, Fabio; Esteve, Jordi; Giebel, Sebastian; Gorin, Norbert C; Schmid, Christoph; Polge, Emmanuelle; Aljurf, Mahmoud; Kroger, Nicolaus; Craddock, Charles; Bacigalupo, Andrea; Cornelissen, Jan J; Baron, Frederic; Unger, Ron; Nagler, Arnon; Mohty, Mohamad

    2015-10-01

    Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentially curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data mining (DM) approach, may serve for transplantation-related mortality risk prediction. This work is a retrospective DM study on a cohort of 28,236 adult HSCT recipients from the AL registry of the European Group for Blood and Marrow Transplantation. The primary objective was prediction of overall mortality (OM) at 100 days after HSCT. Secondary objectives were estimation of nonrelapse mortality, leukemia-free survival, and overall survival at 2 years. Donor, recipient, and procedural characteristics were analyzed. The alternating decision tree machine learning algorithm was applied for model development on 70% of the data set and validated on the remaining data. OM prevalence at day 100 was 13.9% (n=3,936). Of the 20 variables considered, 10 were selected by the model for OM prediction, and several interactions were discovered. By using a logistic transformation function, the crude score was transformed into individual probabilities for 100-day OM (range, 3% to 68%). The model's discrimination for the primary objective performed better than the European Group for Blood and Marrow Transplantation score (area under the receiver operating characteristics curve, 0.701 v 0.646; P<.001). Calibration was excellent. Scores assigned were also predictive of secondary objectives. The alternating decision tree model provides a robust tool for risk evaluation of patients with AL before HSCT, and is available online (http://bioinfo.lnx.biu.ac.il/∼bondi/web1.html). It is presented as a continuous probabilistic score for the prediction of day 100 OM, extending prediction to 2 years. The DM method has proved useful for clinical prediction in HSCT. © 2015 by American Society of Clinical Oncology.

  15. Identity Work and Emotions

    DEFF Research Database (Denmark)

    Winkler, Ingo

    2018-01-01

    This paper reviews the empirical literature on identity work and identifies two distinct approaches to incorporating emotion. The majority of empirical studies use emotion to describe the experiences of identity work. In doing so, the authors (a) mention the emotions that people feel in situations...... that trigger identity work, (b) illustrate identity work as an emotional endeavour, and (c) describe the emotional impact of successful and unsuccessful identity work. There is also an emerging literature that examines the mutual constitution of emotions and identity work. These authors address emotional...... labour, affective social identification, emotional attachment and detachment, and humour when studying identity work. This paper suggests that, to understand better the relation between emotions and identity work, future research should examine the role of emotions in problematizing identity...

  16. Eye Injuries at Work

    Science.gov (United States)

    ... work. Use machine guarding, work screens or other engineering controls. Use proper eye protection. Wear protective eyewear ... Us About the Academy Jobs at the Academy Financial Relationships with Industry Medical Disclaimer Privacy Policy Terms ...

  17. NCPC Commemorative Works Catalog

    Data.gov (United States)

    National Capital Planning Commission — The CWC is a complete list of Washington DC's commemorative works on federal land. Each record includes a work's title, location, a short description of its purpose,...

  18. Ethnography at work

    DEFF Research Database (Denmark)

    Moeran, Brian

    their understanding of their companies' organizational structures, strategies and daily work practices. Asking crucial questions about the role of the anthropologist in the field, "Ethnography at Work" introduces students to ways in which anthropologists study social systems in business....

  19. Work Coordination Engine

    Science.gov (United States)

    Zendejas, Silvino; Bui, Tung; Bui, Bach; Malhotra, Shantanu; Chen, Fannie; Kim, Rachel; Allen, Christopher; Luong, Ivy; Chang, George; Sadaqathulla, Syed

    2009-01-01

    The Work Coordination Engine (WCE) is a Java application integrated into the Service Management Database (SMDB), which coordinates the dispatching and monitoring of a work order system. WCE de-queues work orders from SMDB and orchestrates the dispatching of work to a registered set of software worker applications distributed over a set of local, or remote, heterogeneous computing systems. WCE monitors the execution of work orders once dispatched, and accepts the results of the work order by storing to the SMDB persistent store. The software leverages the use of a relational database, Java Messaging System (JMS), and Web Services using Simple Object Access Protocol (SOAP) technologies to implement an efficient work-order dispatching mechanism capable of coordinating the work of multiple computer servers on various platforms working concurrently on different, or similar, types of data or algorithmic processing. Existing (legacy) applications can be wrapped with a proxy object so that no changes to the application are needed to make them available for integration into the work order system as "workers." WCE automatically reschedules work orders that fail to be executed by one server to a different server if available. From initiation to completion, the system manages the execution state of work orders and workers via a well-defined set of events, states, and actions. It allows for configurable work-order execution timeouts by work-order type. This innovation eliminates a current processing bottleneck by providing a highly scalable, distributed work-order system used to quickly generate products needed by the Deep Space Network (DSN) to support space flight operations. WCE is driven by asynchronous messages delivered via JMS indicating the availability of new work or workers. It runs completely unattended in support of the lights-out operations concept in the DSN.

  20. Reasoning=working Memoryattention

    Science.gov (United States)

    Buehner, M.; Krumm, S.; Pick, M.

    2005-01-01

    The purpose of this study was to clarify the relationship between attention, components of working memory, and reasoning. Therefore, twenty working memory tests, two attention tests, and nine intelligence subtests were administered to 135 students. Using structural equation modeling, we were able to replicate a functional model of working memory…

  1. Motivational Orientations in Work

    Science.gov (United States)

    Murtonen, Mari; Olkinuora, Erkki; Palonen, Tuire; Hakkarainen, Kai; Lehtinen, Erno

    2008-01-01

    The rapid development in working life during recent decades has changed the structures of work organisations and expectations of employees' work. Differing forms of professional employment and different types of organisational environments likely promote different types of motivational patterns in workers. The aim of this study was to apply a…

  2. Authenticity at work

    NARCIS (Netherlands)

    van den Bosch, Ralph

    2016-01-01

    Authenticity at work, loosely defined as the degree to which an individual stays true to their core self, has impact on workers in the workplace. This thesis shows that authenticity at work can be measured with a reliable and valid instrument: the IAM Work. Furthermore, results of this thesis show

  3. Performative Work in Tourism

    DEFF Research Database (Denmark)

    Bærenholdt, Jørgen Ole; Jensen, Hanne Louise

    2009-01-01

    performative work. For many workers, the performative aspect has contributed to their personal development, especially where self-control at work contributes to enhancing self-esteem. Second, performative work is also often vulnerable, involving various emotional strategies to cope with its challenges. While...

  4. Working hours and productivity

    NARCIS (Netherlands)

    Collewet, Marion; Sauermann, Jan

    2017-01-01

    This paper studies the link between working hours and productivity using daily information on working hours and performance of a sample of call centre agents. We exploit variation in the number of hours worked by the same employee across days and weeks due to central scheduling, enabling us to

  5. Work-related stress

    NARCIS (Netherlands)

    Houtman, I.L.D.

    2005-01-01

    Changes in the content and organisation of work in recent decades have resulted in an intensification of work, which is commonly regarded as a cause of stress. This report presents trends in the risks and consequences of work-related stress, and identifies how these can be prevented. The focus

  6. Does Leave Work?

    NARCIS (Netherlands)

    Heleen van Luijn; Saskia Keuzenkamp

    2004-01-01

    More and more people have to combine work and care responsibilities, and work part-time or use daycare and after-school care facilities to help them do so. The Work and Care Act, which came into force on 1 December 2001, combined all the existing schemes - such as parental and maternity leave -

  7. The Developmental Work

    DEFF Research Database (Denmark)

    Møller, Niels; Hvid, Helge

    2001-01-01

    AbstractIn the nineties, the concept of the developmental work (DW) has become a significant point of orientation for the actors on Danish labour market. The DW has moved the focus of the labour market from wages and working time towards work and production. For employees, the DW promises develop...

  8. Live to work or love to work: work craving and work engagement.

    Directory of Open Access Journals (Sweden)

    Kamila Wojdylo

    Full Text Available OBJECTIVE: According to the theory of work craving, a workaholic has a craving for self-worth compensatory incentives and an expectation of relief from negative affect experienced through neurotic perfectionism and an obsessive-compulsive style of working. Research has shown that workaholism and work engagement should be considered as two distinct work styles with different health consequences. However, the mechanisms underlying the adoption of these work styles have been neglected. The present study proposes that work craving and work engagement are differentially associated with self-regulatory competencies and health. In particular, we expected that the working styles mediate the relationships between emotional self-regulation and health. METHODS: In the cross-sectional study, 469 teachers from German schools completed online administered questionnaires. By means of structural equation modeling, we tested two indirect paths: a from self-relaxation deficits via work craving to poor health and b from self-motivation competencies via work engagement to good health. RESULTS: As expected, we found evidence that a the negative relationship of self-relaxation deficits on health was partially mediated by work craving and b the positive relationship of self-motivation competencies on health was partially mediated by work engagement. CONCLUSIONS: The present study emphasizes the importance of self-regulation competencies for healthy or unhealthy work styles. Whereas work craving was associated with a low ability to down-regulate negative emotions and poor health, work engagement was associated with a high ability to up-regulate positive emotions and good health.

  9. Meaning in Work Life

    DEFF Research Database (Denmark)

    Ravn, Ib

        An important aspect of modern work is the meaning that people find in it. Research on this topic has typically asked respondents to name the elements of their work they see as meaningful (e.g., Meaning of Working International Research Team, 1987).     However, a theory of what makes work...... meaningful is still lacking (Harpaz & Fu, 2002), as are definitions of key terms. Here, I define meaning as the experience that something fits into a wider context or coheres within a larger whole.     I conceptualize meaning in work life as deriving from four factors, each of which helps us contribute...

  10. [Rehabilitation and work participation].

    Science.gov (United States)

    Bethge, Matthias

    2017-04-01

    Work participation is increasingly seen as a primary outcome of rehabilitation measures. Randomised controlled trials from several different countries and the reviews and meta-analyses based on them show that multidisciplinary rehabilitation programmes improve work participation, return-to-work rates, and reduce sickness absence in patients with back pain, depression, and cancer. In Germany, such programmes were implemented as work-related medical rehabilitation. This intervention targets patients with poor work ability and an increased risk of permanent work disability. Randomised controlled trials have confirmed a reduction of sickness absence and increased rates of sustainable work participation in favour of work-related medical rehabilitation as compared to common medical rehabilitation. Dissemination of these programmes and translation of research evidence into practice progresses. An additional important strategy to support returning to work following rehabilitation is graded return to work. There is emerging evidence of sustainable employment effects in favour of graded return to work. A direct involvement of the workplace and a closer cooperation with employers and occupational health physicians may further improve the outcomes of rehabilitation programmes. Strategies that synergistically integrate safety, health promotion and rehabilitation may achieve more favourable outcomes than separated actions.

  11. The Ambiguity of work

    DEFF Research Database (Denmark)

    Humle, Didde Maria

    2014-01-01

    This article contributes to the current debate among organizational and work-life researchers on the double-sided nature of knowledge work, which offers great freedom and satisfaction on the one hand and the potential to be overly demanding and stressful on the other. This contribution involves...... drawing on the results of an ethnographic case study of a consultancy house; more spe- cifically, it comprises an exploration of the narrative identity work of consultants as they perform work practice stories of self, work, and the organization negotiating why the work they do is both challenging...... and rewarding. The type of knowledge work explored is characterized by its immaterial nature in the sense that the primary input is the competences, knowledge, and commitment of the consultants and the output is the joy, success, and satisfaction of candidates, clients, and collaborators. The article...

  12. Working with Musculoskeletal Pain

    Science.gov (United States)

    Wynne-Jones, Gwenllian; Varnava, Alice; Main, Chris J; Phillips, Ceri J

    2009-01-01

    Pain has a significant impact on work in terms of presenteeism, sickness absence, and long-term incapacity for work A bio-psychosocial approach is required in understanding pain-related disability and incapacity for work Long-term absence from work is associated with a number of negative outcomes including; poverty, social exclusion and poorer physical and psychosocial well-being Return to work can improve recovery for people with musculoskeletal complaints and pain Interventions to reduce the impact of pain on work can operate at clinical, worker, workplace, and wider systems levels A broader whole systems approach to pain management needs to be adopted, with a greater focus on work retention as well as rehabilitation PMID:26527353

  13. The Ambiguity of Work

    DEFF Research Database (Denmark)

    Humle, Didde Maria

    2014-01-01

    This article contributes to the current debate among organizational and work-life researchers on the double-sided nature of knowledge work, which offers great freedom and satisfaction on the one hand and the potential to be overly demanding and stressful on the other. This contribution involves...... drawing on the results of an ethnographic case study of a consultancy house; more specifically, it comprises an exploration of the narrative identity work of consultants as they perform work practice stories of self, work, and the organization negotiating why the work they do is both challenging...... and rewarding. The type of knowledge work explored is characterized by its immaterial nature in the sense that the primary input is the competences, knowledge, and commitment of the consultants and the output is the joy, success, and satisfaction of candidates, clients, and collaborators. The article...

  14. The Ambiguity of Work

    DEFF Research Database (Denmark)

    Humle, Didde Maria

    2014-01-01

    drawing on the results of an ethnographic case study of a consultancy house; more specifically, it comprises an exploration of the narrative identity work of consultants as they perform work practice stories of self, work, and the organization negotiating why the work they do is both challenging...... source of empirical material in the examination of how we create meaning in relationship to the work we do and the organizations by which we are employed.......This article contributes to the current debate among organizational and work-life researchers on the double-sided nature of knowledge work, which offers great freedom and satisfaction on the one hand and the potential to be overly demanding and stressful on the other. This contribution involves...

  15. Comparison of unrelated cord blood and peripheral blood stem cell transplantation in adults with myelodysplastic syndrome after reduced-intensity conditioning regimen: a collaborative study from Eurocord (Cord blood Committee of Cellular Therapy & Immunobiology Working Party of EBMT) and Chronic Malignancies Working Party

    NARCIS (Netherlands)

    Robin, M.; Ruggeri, A.; Labopin, M.; Niederwieser, D.; Tabrizi, R.; Sanz, G.; Bourhis, J.H.; Biezen, A. van; Koenecke, C.; Blaise, D.; Tischer, J.; Craddock, C.; Maillard, N.; Mohty, M.; Russel, N.; Schetelig, J.; Finke, J.; Gluckman, E.; Witte, T.J. de; Rocha, V.; Kroger, N.

    2015-01-01

    Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment in patients with higher risk myelodysplastic syndrome (MDS), but the choice of the optimal alternative stem cell source is still a subject of debate in patients lacking an HLA-matched sibling donor. Here, we report on

  16. The farrier's work environment.

    Science.gov (United States)

    Löfqvist, Lotta; Pinzke, Stefan

    2012-01-01

    The horse industry in Sweden has rapidly expanded in recent years. This increasing number of horses implies a greater need for more farriers. Shoeing a horse is hard physical work, and includes awkward work postures and repetitive movements. It is well known that hard physical work increases the risk of injuries and musculoskeletal problems. The risk is especially high for musculoskeletal disorders when certain movements are constantly repeated. Heavy or repeated unilateral loads lead to considerable stress on the muscles, which can lead to rupture and fatigue that can cause long term problems. A case study showed that farriers worked 75% of their work time with their backs in bent positions (often more than 70 degrees). Farriers are also exposed to risk factors in their physical environment like dust, noise and poor lighting. Risk of kicks and bites, eye injuries and burns are other factors that make their work environment hazardous. There are only a few studies available that have documented the farriers' working environment and these are not of recent date. A US study from 1984 described kicks and bites from horses, metal splinters in the eyes, heat exhaustion and problematic postures to be perceived as the greatest risks in their work. The back, knees and wrists were the most exposed body regions. There is a need for more current and in-depth studies investigating the farriers' working conditions in order to gain more knowledge of their health and work environment. The aim of the present study is to investigate the physical health and work environment of farriers. The investigation will use questionnaires, work load measurements and workplace analysis. The results will serve as a base for improvements concerning the design of the workplace, equipment, tools and aids as well as supplying recommendations about physical exercise and the correct work technique, etc. The results are planned to be incorporated in the education of farriers.

  17. Dressing up for School Work

    DEFF Research Database (Denmark)

    Brodersen, Ann Christina; Iversen, Ole Sejer

    2007-01-01

    This paper approaches heterogeneity and heterogeneous technology as assets, rather than limitations, in the development of computer supported cooperative work. We demonstrate how heterogeneous technologies sustain teachers’ and students’ school work by presenting four different prototypes (the Hy......ConExplorer, the eCell, the iGameFloor and the eBag) that complement one another because they offer different functionalities and are, at the same time, designed with the wholeness of school activities, particularly group-based ones, in mind. Thus, they provide teachers and students with a broad range of IT support...... to aid them in and outside of the classroom. We take the school domain as our point of departure, but argue that the focus on heterogeneous technologies is applicable for the general area of CSCW....

  18. Extractable Work from Correlations

    Directory of Open Access Journals (Sweden)

    Martí Perarnau-Llobet

    2015-10-01

    Full Text Available Work and quantum correlations are two fundamental resources in thermodynamics and quantum information theory. In this work, we study how to use correlations among quantum systems to optimally store work. We analyze this question for isolated quantum ensembles, where the work can be naturally divided into two contributions: a local contribution from each system and a global contribution originating from correlations among systems. We focus on the latter and consider quantum systems that are locally thermal, thus from which any extractable work can only come from correlations. We compute the maximum extractable work for general entangled states, separable states, and states with fixed entropy. Our results show that while entanglement gives an advantage for small quantum ensembles, this gain vanishes for a large number of systems.

  19. Working around technologies

    DEFF Research Database (Denmark)

    Dupret, Katia

    2017-01-01

    This study discusses how professionalism and work ethics influence how health care professionals work around new technologies. When people avoid using technologies, they are not necessarily ceasing to engage in their work activities. The workaround strategies presented here are rather practical...... expressions of professionals’ active encounter with the complexity of work situations, and can therefore be important signs of professional ethical judgement. Drawing on science and technology studies and the concept of invisible work, the study discusses workaround situations that arise in health care work...... in Denmark. The aim and contribution of the study is twofold. First, it attempts to revitalise the discussion on technology workaround strategies as responsible professionalism. Second, it will direct attention to and contribute to an understanding of how the normativity embedded in technological development...

  20. Unhappy expatriates at work

    DEFF Research Database (Denmark)

    Selmer, Jan; Lauring, Jakob

    2014-01-01

    While some expatriates could feel deeply unhappy trying to deal with the challenges of living and working abroad, few rigorous academic studies have presented evidence of the association between unhappiness among expatriates and their work outcomes. That is surprising since unhappiness could well...... have a substantial effect on performing certain work tasks which is the reason for the foreign assignment. Based on the survey responses of 428 expatriate academics, results of this exploratory study show that unhappiness conceptualised as Subjective Ill-Being (SIB) had a strong negative association...... with work adjustment, work performance, work effectiveness, and job satisfaction as well as a strong positive relationship with time to proficiency. These results are discussed in detail and their implications are drawn....

  1. Organizing Independent Student Work

    Directory of Open Access Journals (Sweden)

    Zhadyra T. Zhumasheva

    2015-03-01

    Full Text Available This article addresses issues in organizing independent student work. The author defines the term “independence”, discusses the concepts of independent learner work and independent learner work under the guidance of an instructor, proposes a classification of assignments to be done independently, and provides methodological recommendations as to the organization of independent student work. The article discusses the need for turning the student from a passive consumer of knowledge into an active creator of it, capable of formulating a problem, analyzing the ways of solving it, coming up with an optimum outcome, and proving its correctness. The preparation of highly qualified human resources is the primary condition for boosting Kazakhstan’s competitiveness. Independent student work is a means of fostering the professional competence of future specialists. The primary form of self-education is independent work.

  2. Back pain - returning to work

    Science.gov (United States)

    Nonspecific back pain - work; Backache - work; Lumbar pain - work; Pain - back - chronic; Low back pain - work; Lumbago - work ... strong. If walking is too hard for you, work with a physical therapist to develop an exercise ...

  3. Predicting sustainable work behavior

    OpenAIRE

    Sundtoft Hald, Kim

    2013-01-01

    Sustainable work behavior is an important issue for operations managers – it has implications for most outcomes of OM. This research explores the antecedents of sustainable work behavior. It revisits and extends the sociotechnical model developed by Brown et al. (2000) on predicting safe behavior. Employee characteristics and general attitudes towards safety and work condition are included in the extended model. A survey was handed out to 654 employees in Chinese factories. This research ...

  4. Analysis of Undesignated Work

    Science.gov (United States)

    2016-04-01

    jobs . So, while they may be cost-effective in producing more months of total work, there may be significant requirements for undesignated work that...able to forecast undesignated work requirements through 2025. We took into account variances in 3 data for Navy platforms contained in the...accessions, and the constant 45 report on board churn that doubles and triples the on-the- job -training (OJT) requirements for ship’s crew

  5. [The chronobiology of work].

    Science.gov (United States)

    Vercellotti, E

    1982-06-16

    The arrival of the industrial age and the availability of artificial light, which lengthens the working day and makes night work possible, have created the problem of man's changing biological functions and rhythms. After a brief note on experimental chronobiology (which permits regulated manipulation of experimental environmental conditions and the study of responses), chronopathology is defined and its implications for man are considered. At present there is no legislation regulating shift work, but it is hoped that the law will take chronobiological methods into account. In this context the basic aspects of shift work are discussed and the two main types - semi-continuous and continuous - are analysed. Firms' experience of shift work is compared with reports in the literature. Present hygiene and environmental conditions, ergonomics and automation combine to make work less and less physically demanding and increase adaptability to shift work. It is therefore hoped that research chronobiology, psychology and psychosociology will provide increasingly precise information about ways of using shift work in the hope of constructing an ecology of the working man.

  6. KAROSHI (WORK TO DEATH

    Directory of Open Access Journals (Sweden)

    Moh. Toriqul Chaer

    2017-05-01

    Full Text Available When the tide of unemployment hit the USA and Europe, in Japan the opposite phenomenon occurs. In 2002, in Japan deaths were recorded because of excessive works. In this country, the phenomenon of death because of excessive works is called Karoshi. Karoshi is common in Japan.  It becomes deadly syndrome as a consequence of long hours works. The debate about deaths from excessive work already sticking out in Japan since the 70s. The first official case of Karoshi was reported in 1969 when a 29-year-old male worker died because of stroke. It is estimated over ten thousand workers died each year due to death by brain and stroke caused by an overload work. Karoshi often happen to male workers dominantly. The main cause of karoshi is stress due to high pressure in the work environment, and work habits of exceeding a  standard of normal working time (8 hours. In addition, their extra time to work is imbalance with and the salary they earn. In its development, the phenomenon of karoshi contributes to the term salaryman and workaholic.

  7. Working with RNA

    DEFF Research Database (Denmark)

    Nielsen, Henrik

    2011-01-01

    Working with RNA is not a special discipline in molecular biology. However, RNA is chemically and structurally different from DNA and a few simple work rules have to be implemented to maintain the integrity of the RNA. Alkaline pH, high temperatures, and heavy metal ions should be avoided when...... possible and ribonucleases kept in check. The chapter outlines the specific precautions recommended for work with RNA and describes some of the modifications to standard protocols in molecular biology that are relevant to RNA work. The methods are applicable to all types of RNA and require a minimum...

  8. Working or shirking?

    OpenAIRE

    Nicholas Bloom; James Liang; John Roberts; Zhichun Jenny Ying

    2012-01-01

    Over 10% of US employees now regularly work from home (WFH), but there is widespread skepticism over its impact highlighted by phrases like "shirking from home". We report the results of a WFH experiment at Ctrip, a 13,000 employee NASDAQ listed Chinese multinational. Call center employees who volunteered to WFH were randomly assigned to work from home or in the office for 9 months. Work from home led to a 13% performance increase, of which about 9.5% is from working more minutes per shift (f...

  9. Human Work Interaction Design

    DEFF Research Database (Denmark)

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume....... The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability...

  10. Work and Rights.

    Science.gov (United States)

    Sen, Amartya

    2000-01-01

    Examines four conceptual features of decent work essential to its achievement in a context of globalization: (1) an inclusive approach, (2) rights-based thinking, (3) placing work within a broad economic, political, and social context, and (4) extension of thinking from international to truly global. Contains 17 references. (JOW)

  11. Successful aging at work

    NARCIS (Netherlands)

    Zacher, Hannes

    2015-01-01

    The expression successful aging at work and related terms such as active, healthy, and productive aging at work are frequently used by organizational researchers and practitioners. However, there are no concrete definitions or theoretical frameworks that explain their meaning, assumptions, and

  12. Work Values across Generations

    Science.gov (United States)

    Hansen, Jo-Ida C.; Leuty, Melanie E.

    2012-01-01

    Mainstream publication discussions of differences in generational cohorts in the workplace suggest that individuals of more recent generations, such as Generation X and Y, have different work values than do individuals of the Silent and Baby Boom generations. Although extant research suggests that age may influence work values, few of the…

  13. Work injuries and disability

    DEFF Research Database (Denmark)

    Tüchsen, Finn; Christensen, Karl Bang; Feveile, Helene

    2009-01-01

    PROBLEM: This study estimated the hazard ratio for disability pension retirement (DPR) for persons who have experienced a work injury causing absence lasting at least one day after the accidental injury occurred and to estimate the fraction of DPR attributable to work injuries. METHODS: A total...

  14. How Does Fluoride Work?

    Science.gov (United States)

    ... A Movies & More Quizzes Kids' Dictionary of Medical Words En Español What Other Kids Are Reading How Does Fluoride Work? Is ... There's fluoride in your toothpaste and even in your water. But how does it work to keep teeth ...

  15. Human Work Interaction Design

    DEFF Research Database (Denmark)

    . The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability...

  16. Working environment committees

    DEFF Research Database (Denmark)

    Scheller, Vibeke Kristine; Hansen, Agnete Meldgaard; Nielsen, Klaus T.

    In Denmark, a new Working Environment Act was passed in 2010. The assumptions behind the act are that increased flexibility in the organization of OHS work will: 1) enable a more systematic approach, 2) elevate OHS issues to a strategic level within the company, and 3) integrate these concerns...

  17. Human Work Interaction Design

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume...

  18. COMMUNICATION OF WORK METHODS.

    Science.gov (United States)

    KONZ, STEPHAN A.; AND OTHERS

    THE ECONOMIC IMPLICATIONS OF PROGRAMED INSTRUCTION FOR WORK TRAINING UNDER CONTROLLED CONDITIONS WERE INVESTIGATED. "WORK TRAINING" REQUIRED THE MEMORIZATION OF PROCEDURES DURING THE TRAINING PERIOD. ONE EXPERIMENT UTILIZED 20 UNSKILLED FEMALES WHO COMPLETED A LAYERED ASSEMBLY BY REFERRING TO A TYPED LIST OR SLIDES OF THE ASSEMBLY WHICH WERE…

  19. European works councils

    DEFF Research Database (Denmark)

    Knudsen, Herman Lyhne

    2003-01-01

    The theme adressed by this paper is the opportunities for European Works Councils (EWCs) of gaining influence on corporate decisions in multinational companies.......The theme adressed by this paper is the opportunities for European Works Councils (EWCs) of gaining influence on corporate decisions in multinational companies....

  20. European works councils

    DEFF Research Database (Denmark)

    Knudsen, Herman Lyhne

    2004-01-01

    The theme addressed by this artcle is the opportunities for European Works Councils of gaining influence on corporate decisions in multinational companies.......The theme addressed by this artcle is the opportunities for European Works Councils of gaining influence on corporate decisions in multinational companies....

  1. Mothers, work and childcare

    NARCIS (Netherlands)

    Ingrid Ooms; Evelien Eggink; Edwin van Gameren

    2007-01-01

    Original title: Moeders, werk en kinderopvang in model. The government wants women to go out to work more. The choices made by women between working and looking after children are accordingly receiving a great deal of attention. This report describes which factors influence these choices by

  2. Back to Work

    Science.gov (United States)

    Fernandez, Kim

    2010-01-01

    The economic downturn hit working America particularly hard, as agricultural, automotive, manufacturing, and retail jobs in many corners of the country all but evaporated. Consumers continue to cut back, and jobless rates in many states have eclipsed levels not seen in decades. Out of work and under pressure, many Americans are turning to the…

  3. Social Work and Science

    Science.gov (United States)

    Gehlert, Sarah

    2016-01-01

    Interest has grown in the past few years about the place of social work in science. Questions remain, such as whether social work should be considered a science, and if so, where it fits into the constellation of sciences. This article attempts to shed light on these questions. After briefly considering past and present constructions of science…

  4. Group Work. Research Brief

    Science.gov (United States)

    Walker, Karen

    2010-01-01

    According to Johnson and Johnson, group work helps increase student retention and satisfaction, develops strong oral communication and social skills, as well as higher self-esteem (University of Minnesota, n.d.). Group work, when planned and implemented deliberately and thoughtfully helps students develop cognitive and leadership skills as well as…

  5. Work based learning

    OpenAIRE

    Adams, David M.

    2014-01-01

    Entry submitted for publication in The SAGE Encyclopedia of Action Research. Provides a full definition of Work based learning, including origins, historical context, significant characteristics, the relationship between work based learning and action research and their shared foundations, and future prospects.

  6. Drafting Work Sample.

    Science.gov (United States)

    Shawsheen Valley Regional Vocational-Technical High School, Billerica, MA.

    This manual contains a work sample intended to assess a handicapped student's interest in and to screen interested students into a training program in basic mechanical drawing. (The course is based on the entry level of an assistant drafter.) Section 1 describes the assessment, correlates the work performed and worker traits required for…

  7. COLD-WORKED HARDWARE

    Directory of Open Access Journals (Sweden)

    N. M. Strizhak

    2007-01-01

    Full Text Available The different types of cold-worked accessory are examined in the article. The necessity of development of such type of accessory in the Republic of Belarus due to requirements of market is shown. High emphasis is placed on the methods of increase of plasticity of cold-worked accessory from usual mill of RUP and CIS countries.

  8. Too old to work?

    Directory of Open Access Journals (Sweden)

    Per Erik Solem

    2009-10-01

    Full Text Available The article reviews Norwegian and international research on aging and work; causes of early exit,attitudes towards older workers, aging and work performance, and trends of changes in working life.Workers seem to have become too old to work at increasingly younger ages. Recent and futuredemographic changes call for initiatives to keep older workers in the work force. In many countriesfavourable early retirement arrangements are reversed in order to stop pulling older workers prematurelyout of work. The other main group of factors causing early exit, the push factors in the work environment,have until recently attracted less attention. Even if older workers in general seem to be no less effectivethan younger workers, employers prefer to recruit younger workers, and to dismiss older workers whenreducing the staff. However, employers’ cognitions of older workes’ performance is quite nuanced. Thereseems to be an emotional ambivalence where negative feelings are less openly expressed, still they seemto have a strong influence on decisions. Ways of influencing attitudes towards older workers arediscussed. Companies creating working conditions to stimulate, include and motivate middle-aged andolder workers may get an advantage in the market. This may even benefit workers of all ages.

  9. How Lungs Work

    Science.gov (United States)

    ... To Quit Help Someone Quit Join Freedom From Smoking GET INVOLVED Events Become An Advocate Volunteer Ways To Give www.lung.org > Lung Health and Diseases > How Lungs Work How Lungs Work The Respiratory System Your lungs are part of the respiratory system, ...

  10. Work zone safety analysis.

    Science.gov (United States)

    2013-11-01

    This report presents research performed analyzing crashes in work zones in the state of New Jersey so as to : identify critical areas in work zones susceptible to crashes and key factors that contribute to these crashes. A field : data collection on ...

  11. Negotiating work identity

    Directory of Open Access Journals (Sweden)

    Tamsen Saayman

    2011-03-01

    Full Text Available Orientation: The study explored the dynamics of work identity negotiation and construction.Research purpose: The aim of the study was to investigate identity tensions and demands that mobilise identity work in the work environment.Motivation for the study: The study hoped to improve the understanding of the dynamics of identity construction and negotiation.Research design, approach and method: Using grounded theory methodology in the context of qualitative field research, the researchers conducted two unstructured interviews with 28 employees of a South African manufacturing company.Main findings: The five primary dimensions the data yielded were personal identity, individual agency, social identity, social practice and job.Practical/managerial implications: This study has implications for organisations that want to improve productivity through understanding work identity.Contribution/value-add: The article presents a conceptual model of the demands and tensions that influence work identity.

  12. Human Work Interaction Design

    DEFF Research Database (Denmark)

    . The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability......This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications....

  13. Human Work Interaction Design

    DEFF Research Database (Denmark)

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume. ......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications........ The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability...

  14. Human Work Interaction Design

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume....... The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications....

  15. [Lifestyle interventions at work?].

    Science.gov (United States)

    Hulshof, Carel T J

    2013-01-01

    So far many worksite lifestyle or health promotion programmes have shown only moderate evidence of effectiveness and cost-effectiveness. However, participation in work is in itself an important determinant of health. For this reason ensuring of fitting work and sustained workability should be an aspect of health policy. Workers' health is not only determined by their working environment but also by health practices and lifestyle factors. Under certain preconditions (e.g. on a voluntary basis, confidentiality, integration with health protection) lifestyle interventions during work time can contribute to a healthier working population. As such programmes may result in financial and social benefits for employers, they should be partly responsible for paying the costs. From a societal perspective, governmental commitment to a preventive policy and the involvement of health and income insurance companies are also required.

  16. Fragmented Work Stories

    DEFF Research Database (Denmark)

    Humle, Didde Maria; Reff Pedersen, Anne

    2015-01-01

    stories. We argue that meaning by story making is not always created by coherence and causality; meaning is created by different types of fragmentation: discontinuities, tensions and editing. The objective of this article is to develop and advance antenarrative practice analysis of work stories......Following a strand of narrative studies pointing to the living conditions of storytelling and the micro-level implications of working within fragmented narrative perspectives, this article contributes to narrative research on work stories by focusing on how meaning is created from fragmented...... by exploring how different types of fragmentation create meanings. This is done by studying the work stories of job and personnel consultants and by drawing on the results of a narrative, ethnographic study of a consultancy. The analysis demonstrates how work stories are social practices negotiated, retold...

  17. Working in virtual knowledge

    DEFF Research Database (Denmark)

    Antonijević, Smiljana; Dormans, Stefan; Wyatt, Sally

    2012-01-01

    of routine, often rather lonely activity contrasts sharply with the much more exciting one of teams of scientists working together in a laboratory, collecting samples, analyzing data and sharing ideas. But the reality of scholarly work in the humanities and social sciences has always been otherwise. Scholars...... possibilities for augmenting or disrupting such collaborative work, by shifting the boundaries between visible and invisible tasks, influencing the division of labor within teams, as well as by bringing to light various affective underpinnings of scholarly practice. In this chapter, we focus on such affective......Scholarly work, especially in the humanities and social sciences, is often seen as solitary. The lone, creative individual, reading and writing while sitting on a chair and gazing out a window, is a powerful image even as it draws attention to the very unglamorous nature of such work. This image...

  18. Fish Stem Cell Cultures

    OpenAIRE

    Hong, Ni; Li, Zhendong; Hong, Yunhan

    2011-01-01

    Stem cells have the potential for self-renewal and differentiation. First stem cell cultures were derived 30 years ago from early developing mouse embryos. These are pluripotent embryonic stem (ES) cells. Efforts towards ES cell derivation have been attempted in other mammalian and non-mammalian species. Work with stem cell culture in fish started 20 years ago. Laboratory fish species, in particular zebrafish and medaka, have been the focus of research towards stem cell cultures. Medaka is th...

  19. Current practices used for the prevention of central venous catheter-associated infection in hematopoietic stem cell transplantation recipients: a survey from the Infectious Diseases Working Party and Nurses' Group of EBMT

    NARCIS (Netherlands)

    Snarski, E.; Mank, A.; Iacobelli, S.; Hoek, J.; Styczyński, J.; Babic, A.; Cesaro, S.; Johansson, E.

    2015-01-01

    Central line-associated bloodstream infection (CLABSI) is one of the most common infectious complications after hematopoietic stem cell transplantation. To prevent this complication, international guidelines recommend the implementation of the CLABSI 'prevention bundle' consisting of hand hygiene,

  20. Electrochemical cell

    Science.gov (United States)

    Nagy, Zoltan; Yonco, Robert M.; You, Hoydoo; Melendres, Carlos A.

    1992-01-01

    An electrochemical cell has a layer-type or sandwich configuration with a Teflon center section that houses working, reference and counter electrodes and defines a relatively narrow electrolyte cavity. The center section is surrounded on both sides with thin Teflon membranes. The membranes are pressed in place by a pair of Teflon inner frames which are in turn supported by a pair of outer metal frames. The pair of inner and outer frames are provided with corresponding, appropriately shaped slits that are in plane generally transverse to the plane of the working electrode and permit X-ray beams to enter and exit the cell through the Teflon membranes that cover the slits so that the interface between the working electrode and the electrolyte within the cell may be analyzed by transmission geometry. In one embodiment, the center section consists of two parts, one on top of the other. Alternatively, the center section of the electrochemical cell may consist of two intersliding pieces or may be made of a single piece of Teflon sheet material. The electrolyte cavity is shaped so that the electrochemical cell can be rotated 90.degree. in either direction while maintaining the working and counter electrodes submerged in the electrolyte.

  1. Hospital nurses' work motivation.

    Science.gov (United States)

    Toode, Kristi; Routasalo, Pirkko; Helminen, Mika; Suominen, Tarja

    2015-06-01

    The knowledge surrounding nurses' work motivation is currently insufficient, and previous studies have rarely taken into account the role of many influential background factors. This study investigates the motivation of Estonian nurses in hospitals, and how individual and organisational background factors influence their motivation to work. The study is quantitative and cross-sectional. An electronically self-reported questionnaire was used for data collection. The sample comprised of 201 Registered Nurses working in various hospital settings in Estonia. Data were analysed using descriptive statistics, two-sample Wilcoxon rank-sum (Mann-Whitney) test, Kruskal-Wallis equality-of-populations rank test and Spearman's correlation. Both extrinsic and intrinsic motivations were noted among hospital nurses. Nurses were moderately externally motivated (M = 3.63, SD = 0.89) and intrinsically strongly motivated (M = 4.98, SD = 1.03). A nurses' age and the duration of service were positively correlated with one particular area of extrinsic work motivation, namely introjected regulation (p extrinsic motivation (p = 0.016) and intrinsic work motivation (p = 0.004). The findings expand current knowledge of nurses' work motivation by describing the amount and orientation of work motivation among hospital nurses and highlighting background factors which should be taken into account in order to sustain and increase their intrinsic work motivation. The instrument used in the study can be an effective tool for nurse managers to determine a nurse's reasons to work and to choose a proper motivational strategy. Further research and testing of the instrument in different countries and in different contexts of nursing is however required. © 2014 Nordic College of Caring Science.

  2. Making motherhood work

    Directory of Open Access Journals (Sweden)

    Rachel Thomson

    2011-07-01

    Full Text Available Motherhood can be a critical moment in the making of gendered biographies, and in the negotiation of a gendered division of labour within a household. This paper draws on the 'Making of Modern Motherhoods' study, which combined interviews with a diverse group of expectant first time mothers and family case studies in order to build an intergenerational and longitudinal perspective on contemporary mothering situations within the UK. In this paper, the category 'work' is used as a lens through which to encounter new motherhood. After contextualising working motherhood in relation to a sociological literature the paper draws on interviews undertaken with women towards the end of their pregnancy with their first child to reveal something of the emergent collision of working and maternal identities, women's experiences of being pregnant at work including the anticipation and managing of maternity leave. The second part presents a case study, which animates the personal drama involved in reconciling working and maternal commitments, tracing how a woman's feelings about work change over time in negotiation with partner, family and the market. As Sue Sharpe observed in her 1984 book on working mothers, 'full-time mothering has never been accessible to all women in the same way at the same time' (1984: 22. Social class, locality and migration shape a range of cultures of mothering within which work features very differently. Divisions exist between women who share a generational location as well as between women of different generations. This complexity is revealed through a juxtaposition of the voices of mothers and grandmothers, which show how work may both, divide and unite women in the project of motherhood.

  3. Work and Home

    Science.gov (United States)

    ... Disease T Cells d What Causes MS? Disproved Theories Viruses Clusters d Who Gets MS? Pediatric MS ... Review of Society's Research Programs d Careers d Leadership Board of Directors Senior Leadership Team Founder Sylvia ...

  4. How connected vehicles work.

    Science.gov (United States)

    2011-01-01

    Connected vehicles have the potential to transform the way Americans travel through the creation : of a safe, interoperable wireless communications networka system that includes cars, buses, : trucks, trains, traffic signals, cell phones, and othe...

  5. Work environment quality

    DEFF Research Database (Denmark)

    Knudsen, Herman; Busck, Ole Gunni; Lind, Jens

    2011-01-01

    The article explores how employee participation influences the quality of the work environment and workers’ well-being at 11 Danish workplaces from within six different industries. Both direct participation and representative forms of participation at the workplace level were studied. Statistical...... as well as qualitative comparative analyses reveal that work environment quality and high levels of participation go hand in hand. Within a typology of participation models the highest level of participation, including strong elements of collective participation, and also the best work environment...

  6. Ethnography at work

    DEFF Research Database (Denmark)

    Moeran, Brian

    that of a rival firm. "Ethnography at Work" follows the experiences of the author as a participant observer in the day-to-day running of a Japanese advertising agency. The book reveals the intricate behind-the-scenes planning, discussion, negotiations and strategies needed to ensure that the agency's presentation...... their understanding of their companies' organizational structures, strategies and daily work practices. Asking crucial questions about the role of the anthropologist in the field, "Ethnography at Work" introduces students to ways in which anthropologists study social systems in business....

  7. Learned helplessness at work.

    Science.gov (United States)

    Lennerlöf, L

    1988-01-01

    The development of theory and research on learned helplessness is reviewed and criticized on some points, e.g., for its reliance on artificial laboratory experiments. Some empirical findings are presented, indicating a connection between certain work characteristics and learned helplessness. Other research traditions have emphasized the importance of job qualifications, freedom of action, and development possibilities for well-being and health. There is, however, hardly and research on learned helplessness at work. Learned helplessness hypotheses should be tested on data from real life; if applied to work environment research, the theory of learned helplessness could generate important results.

  8. Apparel at Work

    DEFF Research Database (Denmark)

    Bjerck, Mari

    project called Uni-Form funded by the Research Council of Norway. The dissertation presents findings from ethnographic fieldwork in six male-dominated occupations; construction, skilled manual work, industrial production, off- and onshore gas and oil production, industrial fishing and the Navy. It also...... analyses the project Uni-Form’s product development process and seeks to show how work research can benefit from employing more materiality-based studies. Work clothes and uniforms for women in male-dominated occupations have come in the form of men’s clothes or feminized copies of men's clothes where form......This dissertation is concerned with work uniforms for women in male-dominated manual occupations. As such, it has analysed parts of the gender-segregated labour market in light of material conditions that dress workers every day. This has been done on the background of a research and development...

  9. Work Practice Characteristics

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    2003-01-01

    investigation of how groupware is employed to support new ways of working in a large European financial organisation are analysed to illustrate situations with high and low integration of groupware. The framework of work practice characteristics is discussed in the light of these findings and implications......Integrating groupware in work practices poses a range of interrelated problems comprising organisational and technological issues. These are complex issues, since they derive from the combined influence of a range of heterogeneous elements and emergent phenomena in the intersection of groupware...... supported cooperative work (CSCW) the paper argues that the interrelations of heterogeneous elements and emergent phenomena arising from the integration of groupware in practice should be made visible from a perspective encompassing both the social and the technical. Two cases from an empirical...

  10. Audit of public work

    Directory of Open Access Journals (Sweden)

    Valtencir Godinho de Camargo

    2011-09-01

    Full Text Available The municipal public works, especially the reform and small constructions, with mobilization of manpower with up to 20 employees, where it is not mandatory elaboration of Program Conditions and Work Environment in the Construction Industry, are conducted without meeting the regulatory norm, which are motivated by the deficiency in the elaboration of the budget, the bidding documents, in the contract and supervision. The unfamiliarity specialized in the area of the Engineering of Safety of the Work adds to the factors that lead the public agency take unnecessary risks, as the objective responsibility, the labor charges and indemnities for illnesses, accidents or deaths. This article aims to indicate the guidelines for the program to health and safety is applied effectively in public works.

  11. Social Work Research

    DEFF Research Database (Denmark)

    Social work research has gathered a greater transparency and clarity of identity in North American and parts of Europe. Furthermore, the rapid emergence of social work research in other European countries, China, India, Japan and elsewhere in Asia and Pacific Rim countries, and gradually in South...... America, has created a need for a collection that can contribute to both shaping and making accessible key and sometimes hard-to-access sources. This four-volume collection answers this need, bringing together key literature in a single resource and structuring it into thematic volumes to enable clear...... understanding of the different aspects involved in the research. Volume One: Historical Trajectories, Purposes and Key Concepts Volume Two: Key Decisions about Research Strategy Volume Three: The Practice of Social Work Research Volume Four: The Contexts of Social Work Research...

  12. Work finishes on CNGS

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Construction work on the CERN Neutrinos to Gran Sasso (CNGS) project is completed. These views are of the l km long CNGS vacuum tube, where particles decay to produce neutrinos, just before it is sealed.

  13. Play at Work

    DEFF Research Database (Denmark)

    Meier Sørensen, Bent; Spoelstra, Sverre

    2012-01-01

    The interest in organizational play is growing, both in popular business discourse and organization studies. As the presumption that play is dysfunctional for organizations is increasingly discarded, the existing positions may be divided into two camps; one proposes ‘serious play’ as an engine...... for business and the other insists that work and play are largely indistinguishable in the postindustrial organization. Our field study of a design and communications company in Denmark shows that organizational play can be much more than just functional to the organization. We identify three ways in which...... workplaces engage in play: play as a (serious) continuation of work, play as a (critical) intervention into work and play as an (uninvited) usurpation of work....

  14. Coordinating Work with Groupware

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    2003-01-01

    One important goal of employing groupware is to make possible complex collaboration between geographically distributed groups. This requires a dual transformation of both technology and work practice. The challenge is to re­duce the complexity of the coordination work by successfully inte......­grating the protocol stipulating the collaboration and the ar­te­fact, in form of the groupware application, mediating the col­laboration. This paper analyses a generic groupware application that was deployed in a large financial organisation in order to support working groups distributed throughout four countries....... Using the CSCW frame­work of coordination mechanisms, we have elicited six general factors influencing the integration of the groupware application in two situations....

  15. Ticket To Work

    Data.gov (United States)

    Social Security Administration — Captures information on disability beneficiaries that are participating in one of the "the return to work initiative"; to help become self sufficient, and to limit...

  16. HIP OSTEOARTHRITIS AND WORK

    Science.gov (United States)

    Harris, E Clare; Coggon, David

    2016-01-01

    Epidemiological evidence points strongly to a hazard of hip osteoarthritis from heavy manual work. Harmful exposures may be reduced by elimination or redesign of processes and use of mechanical aids. Reducing obesity might help to protect workers whose need to perform heavy lifting cannot be eliminated. Particularly high relative risks have been reported in farmers, and hip osteoarthritis is a prescribed occupational disease in the UK for long-term employees in agriculture. Even where it is not attributable to employment, hip osteoarthritis impacts importantly on capacity to work. Factors that may influence work participation include the severity of disease, the physical demands of the job, age, and the size of the employer. Published research does not provide a strong guide to the timing of return to work following hip arthroplasty for osteoarthritis, and it is unclear whether patients should avoid heavy manual tasks in their future employment. PMID:26612242

  17. Patterns of Work Identification

    Science.gov (United States)

    Hebden, J. E.

    1975-01-01

    The paper examines ways in which the concept of work identification may provide a useful means of delineating the boundaries of occupational groups. Two kinds of identification are discussed: identification with employing organizations and identification with occupation.

  18. Refugees’ rights to work

    Directory of Open Access Journals (Sweden)

    Emily E Arnold-Fernández

    2013-09-01

    Full Text Available Host economies benefit when refugees work. Nations seeking economic growth and political stability should allow refugees to access employment and to enjoy employment-related rights.

  19. Pregnancy and work

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000609.htm Pregnancy and work To use the sharing features on this page, ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  20. Work and Inertial Frames

    Science.gov (United States)

    Kaufman, Richard

    2017-12-01

    A fairly recent paper resolves a large discrepancy in the internal energy utilized to fire a cannon as calculated by two inertial observers. Earth and its small reaction velocity must be considered in the system so that the change in kinetic energy is calculated correctly. This paper uses a car in a similar scenario, but considers the work done by forces acting over distances. An analysis of the system must include all energy interactions, including the work done on the car and especially the (negative) work done on Earth in a moving reference frame. This shows the importance of considering the force on Earth and the distance Earth travels. For calculation of work in inertial reference frames, the center of mass perspective is shown to be useful. We also consider the energy requirements to efficiently accelerate a mass among interacting masses.

  1. Aeromobility and work

    DEFF Research Database (Denmark)

    Lassen, Claus

    2006-01-01

    . The boundary between work and tourism is not distinct and there is a very complex connection between travel, work, tourism, and play. He shows that actually, there is a strong ‘material' impact from supposedly ‘immaterial' organisations and this ‘materiality' is particularly linked to the extension of forms......In this paper, the hypothesis is that there is a connection between international aeromobility, knowledge organisations, and environmental impacts. The object is therefore to examine the driving forces, mechanisms, and patterns of meaning behind the increase in international long-distance work...... mobility. The author will draw on a case study which involves two Danish examples of ‘knowledge organisations'. He argues that it is necessary to rethink central concepts of travel, tourism, and working life, in order to understand and describe this kind of international mobility in these organisations...

  2. Sustainable Commuting @Work

    Directory of Open Access Journals (Sweden)

    S. Castellani

    2014-10-01

    Full Text Available Local governments are seeking effective ways to promote sustainable commuting for reducing energy consumption and improving commuters’ experience. They often use so-called “Workplace Travel Plans” as policy interventions to engage work organizations as active players, promoting sustainable commuting amongst their employees. However, it remains difficult to systematically engage work organizations and commuters in such efforts for a number of reasons, ranging from preferences to constraints that they have to deal with. We aim at providing commuters, work organizations, and public administrators with tools that facilitate this engagement. In this paper, we discuss the requirements for the design of technology supporting corresponding services for commuters and work organizations and we shortly illustrate the infrastructure that we are developing to provide such services.

  3. RadWorks Project

    Data.gov (United States)

    National Aeronautics and Space Administration — For the first two years of the project (FY12-13), the RadWorks project has consisted of two top-level elements. The first element involved the prototype and...

  4. Evolution of working memory

    National Research Council Canada - National Science Library

    Peter Carruthers

    2013-01-01

    Working memory (WM) is fundamental to many aspects of human life, including learning, speech and text comprehension, prospection and future planning, and explicit "system 2" forms of reasoning, as well as overlapping...

  5. How the Body Works

    Science.gov (United States)

    ... Weight for Me? What Is an Intellectual Disability? Movie: Endocrine System How the Body Works Main ... consult your doctor. © 1995- The Nemours Foundation. All rights reserved. Images provided by The Nemours Foundation, iStock, Getty Images, ...

  6. Work and Recognition

    DEFF Research Database (Denmark)

    Willig, Rasmus

    2004-01-01

    individual and collective identity formation and has led to an increase in social pathological illnesses such as stress and depression. By juxtaposing these analyses with Honneth’s theory on recognition, we conclude that the contemporary logic of work is unable to provide adequate forms of recognition......The article deals with the relationship between work and recognition, taking Axel Honneth’s social-philosophical theory of the struggle for recognition as its point of departure. In order to give sociological substance to Honneth’s theory, we turn to three contemporary social theorists - Jean......-Pierre Le Goff, Christophe Dejours and Emmanuel Renault. In spite of many differences, their work is united by a critical description of the logic of work and its consequences for individual individuation. These theorists agree that the growth of autonomy, flexibility and mobility has destabilised...

  7. Analysis of Undesignated Work

    Science.gov (United States)

    2016-04-01

    CNP Chief of Naval Personnel CNSF Commander, Naval Surface Forces (COMNAVSURFOR) CREO Career Reenlistment Objective CS Culinary Specialist EC...section, we define undesignated work and review the history of the demand for undesignated work over time. Since the standup of the All-Volunteer Force...Further, when transitioning BA from ratings to PACT, they overestimated sailors’ propensity for the Culinary Specialist (CS) and Mineman (MN

  8. Multicultural group work

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2014-01-01

    Motivation for the activity I use this strategy for forming groups to ensure diverse/multicultural groups that combine a variety of different strengths and resources based on student's academic, disciplinary, linguistic, national, personal and work backgrounds.......Motivation for the activity I use this strategy for forming groups to ensure diverse/multicultural groups that combine a variety of different strengths and resources based on student's academic, disciplinary, linguistic, national, personal and work backgrounds....

  9. Work related shoulder disorders

    DEFF Research Database (Denmark)

    Svendsen, Susanne Wulff; Bonde, Jens Peter; Mathiassen, S.E.

    2004-01-01

    Aims: To determine quantitative exposure-response relations between work with highly elevated arms and supraspinatus tendinitis, shoulder pain with disability, and shoulder pain without disability. Methods: A cross sectional study was conducted in a historical cohort of 1886 males from three occu...... between current work with highly elevated arms and clinically verified shoulder disorders. Substantial long term cumulative effects were not shown. A potential for primary prevention was revealed....

  10. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience, IT Department

  11. Quality of work life

    OpenAIRE

    Jaiswal, Anshul

    2014-01-01

    Although studies on the Quality of work Life (QWL) have been conducted since the early 20th century, there is no consensus about the real meaning of this term. Over the last years, QWL has been understood as the dynamic and comprehensive management of physical, technological, social and psychological factors that affect culture and renew the organizational environment. Quality of work life (QWL) and employee job satisfaction are increasingly being identified as progressive indicators related ...

  12. Existential Social Work

    Directory of Open Access Journals (Sweden)

    Donald F. Krill

    2014-05-01

    Full Text Available The existential impact upon social work began in the 1960’s with the emphasis upon freedom, responsibility and a sense of the absurd. It affirmed human potential while faulting the deterministic thinking that was popular with psychological theorists at that time. It was open to the prospects of spirituality, but was less than optimistic concerning great progress among social institutions. It was a forerunner to the strengths-based social work programs of our present day.

  13. Language Works. Linguistic Journal

    DEFF Research Database (Denmark)

    Hartling, Anna Sofie; Nørreby, Thomas Rørbeck; Skovse, Astrid Ravn

    2016-01-01

    Language works! – and with this initiative and this journal we want to give the opportunity to many more students to present their linguistic research to each other, to the scientific community and to all interested.......Language works! – and with this initiative and this journal we want to give the opportunity to many more students to present their linguistic research to each other, to the scientific community and to all interested....

  14. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period, access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience. IT Department

  15. Insomnia in shift work.

    Science.gov (United States)

    Vallières, Annie; Azaiez, Aïda; Moreau, Vincent; LeBlanc, Mélanie; Morin, Charles M

    2014-12-01

    Shift work disorder involves insomnia and/or excessive sleepiness associated with the work schedule. The present study examined the impact of insomnia on the perceived physical and psychological health of adults working on night and rotating shift schedules compared to day workers. A total of 418 adults (51% women, mean age 41.4 years), including 51 night workers, 158 rotating shift workers, and 209 day workers were selected from an epidemiological study. An algorithm was used to classify each participant of the two groups (working night or rotating shifts) according to the presence or absence of insomnia symptoms. Each of these individuals was paired with a day worker according to gender, age, and income. Participants completed several questionnaires measuring sleep, health, and psychological variables. Night and rotating shift workers with insomnia presented a sleep profile similar to that of day workers with insomnia. Sleep time was more strongly related to insomnia than to shift work per se. Participants with insomnia in the three groups complained of anxiety, depression, and fatigue, and reported consuming equal amounts of sleep-aid medication. Insomnia also contributed to chronic pain and otorhinolaryngology problems, especially among rotating shift workers. Work productivity and absenteeism were more strongly related to insomnia. The present study highlights insomnia as an important component of the sleep difficulties experienced by shift workers. Insomnia may exacerbate certain physical and mental health problems of shift workers, and impair their quality of life. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Measuring return to work.

    Science.gov (United States)

    Wasiak, Radoslaw; Young, Amanda E; Roessler, Richard T; McPherson, Kathryn M; van Poppel, Mireille N M; Anema, Johannes R

    2007-12-01

    It is argued that one of the factors limiting the understanding of return to work (RTW) following work disability is the use of measurement tools that do not capture a complete picture of workers' RTW experiences. To facilitate the investigation of RTW, the current authors proposed a developmental conceptualization of RTW, which argues for an expanded awareness that encompasses four phases: off work, work reintegration, work maintenance and advancement. This paper reports on work undertaken with the aim of operationalizing the conceptualization. A review of the RTW and related literature, with databases searched including PubMed, EconLit, and PsycInfo. We began by extracting details of RTW instruments used by previous researchers. We then interpreted these within the context of the phases of RTW. Using the International Classification of Functioning, Disability, and Health (ICF) to inform our thinking and coding structure, we conceptualized phase-based RTW outcomes and categorized them as 'tasks and actions', 'contextual' or 'process driven'. Iteratively, we reviewed existing instruments for their use as measures of RTW. Where gaps in instrumentation were found, the wider vocational and career assessment literature was searched for instruments that could be adapted for use in RTW research. Results indicate that, although numerous research instruments have been used to assess RTW, within the scientific literature some important dimensions of RTW lack instrumentation. In particular, we found that outcomes such as goal setting, motivation, expectation, job seeking, work maintenance, and career advancement require operationalization. Amongst the outcomes had been operationalized, we found considerable variation in conceptual development and application. The lack of consistency and comprehensiveness of RTW measurement is one of the factors compromising the advancement of the field of RTW research. It is suggested that a more complete and psychometrically sound array of

  17. Conserving tigers in working landscapes.

    Science.gov (United States)

    Chanchani, Pranav; Noon, Barry R; Bailey, Larissa L; Warrier, Rekha A

    2016-06-01

    Tiger (Panthera tigris) conservation efforts in Asia are focused on protected areas embedded in human-dominated landscapes. A system of protected areas is an effective conservation strategy for many endangered species if the network is large enough to support stable metapopulations. The long-term conservation of tigers requires that the species be able to meet some of its life-history needs beyond the boundaries of small protected areas and within the working landscape, including multiple-use forests with logging and high human use. However, understanding of factors that promote or limit the occurrence of tigers in working landscapes is incomplete. We assessed the relative influence of protection status, prey occurrence, extent of grasslands, intensity of human use, and patch connectivity on tiger occurrence in the 5400 km(2) Central Terai Landscape of India, adjacent to Nepal. Two observer teams independently surveyed 1009 km of forest trails and water courses distributed across 60 166-km(2) cells. In each cell, the teams recorded detection of tiger signs along evenly spaced trail segments. We used occupancy models that permitted multiscale analysis of spatially correlated data to estimate cell-scale occupancy and segment-scale habitat use by tigers as a function of management and environmental covariates. Prey availability and habitat quality, rather than protected-area designation, influenced tiger occupancy. Tiger occupancy was low in some protected areas in India that were connected to extensive areas of tiger habitat in Nepal, which brings into question the efficacy of current protection and management strategies in both India and Nepal. At a finer spatial scale, tiger habitat use was high in trail segments associated with abundant prey and large grasslands, but it declined as human and livestock use increased. We speculate that riparian grasslands may provide tigers with critical refugia from human activity in the daytime and thereby promote tiger occurrence

  18. Bike 2 Work

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Are you a CERN cyclist? If so, join the Bike 2 Work competition that has just started! The more kilometres you travel by bike, the closer you’ll get to winning…   Yngve Inntjore Levinsen works at CERN, in the BE Department, and is one of the many people who travel to work by bike. Convinced by the benefits and the well-being that this mode of transport brings, he decided to promote it by running a competition. “Everyone working at CERN can participate,” says Yngve. “They just need to sign up on the competition website, or via their Facebook login. Then, participants simply have to report regularly the number of kilometres they cover by bike, travelling between home and work, or during the day between different points at CERN. ” The competition began on 1 March and will last all year long. The 2012 results will be announced at the end of the year. Of course, the winner will be the cyclist who has travelled the most kilometres during the ...

  19. ALARA and work management

    Energy Technology Data Exchange (ETDEWEB)

    Schieber, C. [Centre d`etude sur l`Evaluation de la Protection dans le domaine Nucleaire, Fontenay-aux-Roses (France); Perin, M. [Environmental Radiation Protection and Security Dept., Saint-Denis (France); Saumon, P. [Framatome, Lyon (France)

    1995-03-01

    At the request of Electricite de France (EDF) and Framatome, the Nuclear Protection Evaluation Centre (CEPN) developed a three-year research project, between 1991 and 1993, to evaluate the impact of various work management factors that can influence occupational exposures in nuclear power plants (NPPs) and to assess the effectiveness of protective actions implemented to reduce them. Three different categories of factors have been delineated: those linked to working conditions (such as ergonomic of work areas and protective suits), those characterizing the operators (qualification, experience level, motivation, etc.). In order to quantify the impact of these factors, a detailed survey was carried out in five French NPPs, focusing on three types of operations: primary valves maintenance, decontamination of reactor cavity, and specialized maintenance operations on the steam generator. This survey was augmented by a literature review on the influence of {open_quotes}hostile{close_quotes} environment on working conditions. Finally, a specific study was performed in order to quantify the impact of various types of protective suits used in French nuclear installations according to the type of work to be done. All of these factors have been included in a model aiming at quantifying the effectiveness of protection actions, both from dosimetric and economic point of views.

  20. Working Memory and Neurofeedback.

    Science.gov (United States)

    YuLeung To, Eric; Abbott, Kathy; Foster, Dale S; Helmer, D'Arcy

    2016-01-01

    Impairments in working memory are typically associated with impairments in other cognitive faculties such as attentional processes and short-term memory. This paper briefly introduces neurofeedback as a treatment modality in general, and, more specifically, we review several of the current modalities successfully used in neurofeedback (NF) for the treatment of working memory deficits. Two case studies are presented to illustrate how neurofeedback is applied in treatment. The development of Low Resolution Electromagnetic Tomography (LORETA) and its application in neurofeedback now makes it possible to specifically target deep cortical/subcortical brain structures. Developments in neuroscience concerning neural networks, combined with highly specific yet practical NF technologies, makes neurofeedback of particular interest to neuropsychological practice, including the emergence of specific methodologies for treating very difficult working memory (WM) problems.

  1. Ethnography at work

    DEFF Research Database (Denmark)

    Moeran, Brian

    to a potential client will be preferred over that of a rival firm. The book shows how detailed ethnography can lead to an understanding of numerous different, but interlocking, theoretical issues. It demonstrates how ethnography can travel beyond the academic realm and be used by business personnel to heighten...... their understanding of their companies' organizational structures, strategies and daily work practices. Asking crucial questions about the role of the anthropologist in the field, "Ethnography at Work" introduces students to ways in which anthropologists study social systems in business....... that of a rival firm. "Ethnography at Work" follows the experiences of the author as a participant observer in the day-to-day running of a Japanese advertising agency. The book reveals the intricate behind-the-scenes planning, discussion, negotiations and strategies needed to ensure that the agency's presentation...

  2. Reconfigurable assembly work station

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yhu-Tin; Abell, Jeffrey A.; Spicer, John Patrick

    2017-11-14

    A reconfigurable autonomous workstation includes a multi-faced superstructure including a horizontally-arranged frame section supported on a plurality of posts. The posts form a plurality of vertical faces arranged between adjacent pairs of the posts, the faces including first and second faces and a power distribution and position reference face. A controllable robotic arm suspends from the rectangular frame section, and a work table fixedly couples to the power distribution and position reference face. A plurality of conveyor tables are fixedly coupled to the work table including a first conveyor table through the first face and a second conveyor table through the second face. A vision system monitors the work table and each of the conveyor tables. A programmable controller monitors signal inputs from the vision system to identify and determine orientation of the component on the first conveyor table and control the robotic arm to execute an assembly task.

  3. Connecting work and education

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    2004-01-01

    The aim of this article is to examine the interplay between learning in school and learning in the workplace - and its problems. Historically, education and work have become separated and each developed its own rationale – a school rationale and a production rationale, both of which may form...... the foundation for interplay. Concurrently with this, the learners apply a subjective rationale based on their personal expectations and interests in education and work in the course of their lives. Using the three players, school, work place and employee as a starting point, three different rationales upon...... which to base interplay can be deduced. Since viable interplay may not be established based on one rationale alone, we need an institutional framework to mediate between them. This article proposes that a modernized version of the Dual System of vocational education may be best to provide...

  4. Distributed Project Work

    DEFF Research Database (Denmark)

    Borch, Ole; Kirkegaard, B.; Knudsen, Morten

    1998-01-01

    for information exchange in the traditional project environment is performed. A group of teachers and a student group using small project examples test the method. The first test group used a prototype for testing and found the new activity synchronization difficult to adapt, so the method was finally adjusted...... to be very precises and with success used on the second test group. Distributed project work is coming pretty soon and with little improvement in server tools, projects in different topics with a large and inhomogeneous profile of users are realistic.......Project work has been used for many years at Aalborg University to improve learning of theory and methods given in courses. In a closed environment where the students are forming a group in a single room, the interaction behaviour is more or less given from the natural life. Group work...

  5. American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma

    DEFF Research Database (Denmark)

    Giralt, Sergio; Garderet, Laurent; Durie, Brian

    2015-01-01

    In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has ...

  6. Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk Chronic Lymphocytic Leukemia - A Retrospective Analysis From the Chronic Malignancies Working Party of the EBMT

    DEFF Research Database (Denmark)

    van Gelder, Michel; Ziagkos, Dimitris; de Wreede, Liesbeth

    2017-01-01

    BACKGROUND: Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free survival (PFS) with kinase- and BCL2-inhibitors (KI, BCL2i). Allogeneic hematopoietic stem cell transplantation (alloHCT) may result in sustained PFS, especially i...

  7. Capillary-based micro-battery cell for in situ X-ray powder diffraction studies of working batteries: a study of the initial intercalation and deintercalation of lithium into graphite

    DEFF Research Database (Denmark)

    Johnsen, Rune; Norby, Poul

    2013-01-01

    to obtain diffraction from a single electrode at a time, which facilitates detailed structural and microstructural studies of the electrode materials. The micro-battery cell is potentially also applicable for in situ X-ray absorption spectroscopy and smallangle X-ray scattering experiments. The in situ XRPD...

  8. Work environment factors and work sustainability in Norwegian cooks

    National Research Council Canada - National Science Library

    Svedahl, Sindre Rabben; Svendsen, Kristin; Romundstad, Pål R; Qvenild, Torgunn; Strømholm, Tonje; Aas, Oddfrid; Hilt, Bjørn

    .... We aimed to elucidate work environment and work sustainability in Norwegian cooks. A questionnaire inquiring about working conditions and work participation was sent to 2082 cooks who had qualified from 1988 onwards...

  9. Organizing design work

    DEFF Research Database (Denmark)

    Scheuer, John Damm

    2016-01-01

    The aim of this paper is to demonstrate the importance of the kind of understanding of organizing that is implied by design theories for project managers' understanding and organizing of design work. Five theories and their organizing consequences for project managers organizing of design work...... are analyzed. The paper contributes to design research and organization studies by putting the organizing of design projects on the research agenda. It also contributes by demonstrating the importance of being aware of the ontological and epistemological assumptions and organizing consequences of different...

  10. Work breakdown structure guide

    Energy Technology Data Exchange (ETDEWEB)

    1987-02-06

    Utilization of the work breakdown structure (WBS) technique is an effective aid in managing Department of Energy (DOE) programs and projects. The technique provides a framework for project management by focusing on the products that are being developed or constructed to solve technical problems. It assists both DOE and contractors in fulfilling their management responsibilities. This document provides guidance for use of the WBS technique for product oriented work identification and definition. It is one in a series of policy and guidance documents supporting DOE's project manaagement system.

  11. Distributed Project Work

    DEFF Research Database (Denmark)

    Borch, Ole; Kirkegaard, B.; Knudsen, Morten

    1998-01-01

    for information exchange in the traditional project environment is performed. A group of teachers and a student group using small project examples test the method. The first test group used a prototype for testing and found the new activity synchronization difficult to adapt, so the method was finally adjusted......Project work has been used for many years at Aalborg University to improve learning of theory and methods given in courses. In a closed environment where the students are forming a group in a single room, the interaction behaviour is more or less given from the natural life. Group work...

  12. Motorway maintenance work

    CERN Multimedia

    2005-01-01

    Built 20 years ago, the airport section of the Geneva motorway bypass is now in need of maintenance work and alterations to bring it into line with the new standards. Two-lane traffic will be maintained in both directions during the work, which will be carried out in 2006 and 2007, but there will be various temporary special traffic arrangements in force. We should like to thank you in advance for your understanding. Civil Engineering Department, DAEL, State of Geneva More information: tel. 163 or www.autoroute-aeroport.ch Fewer cars, fewer traffic jams, with www.covoiturage.ch

  13. Human Work Interaction Design

    DEFF Research Database (Denmark)

    Gonçalves, Frederica; Campos, Pedro; Clemmensen, Torkil

    2015-01-01

    In this paper, we review research in the emerging practice and research field of Human Work Interaction Design (HWID). We present a HWID frame-work, and a sample of 54 papers from workshops, conferences and journals from the period 2009-2014. We group the papers into six topical groups, and then at....... Furthermore, much focus has been on studying design sketching or implemented systems-in-use, while little attention has been paid to mature design (prototypes) or early implementation (content templates). In conclusion, we recommend an update to the framework so that it can be also useful for research...

  14. 30 CFR 75.332 - Working sections and working places.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Working sections and working places. 75.332... and working places. (a)(1) Each working section and each area where mechanized mining equipment is... simultaneously engaged in cutting, mining, or loading coal or rock from working places within the same working...

  15. How Do Pain Relievers Work? (For Kids)

    Science.gov (United States)

    ... Pain relievers work with your cells, your body's nerve endings, your nervous system , and your brain to keep you from feeling ... to this chemical. When prostaglandin is released, the nerve endings respond ... through the nervous system to the brain. They tell the brain everything ...

  16. Working With New Designs

    DEFF Research Database (Denmark)

    Visholm, Steen; Beck, Ulla Charlotte

    2014-01-01

    In this paper the learning concept of group relations conferences are discussed. The authors have worked with group relations conferences (GRC) in different contexts for many years-mainly as a part of educational programmes for managers and consultants (OPU at IGA Copenhagen, MPO at Roskilde...

  17. Outsourcing of experimental work

    DEFF Research Database (Denmark)

    Nielsen, Henrik

    2011-01-01

    With the development of new technologies for simultaneous analysis of many genes, transcripts, or proteins (the "omics" revolution), it has become common to outsource parts of the experimental work. In order to maintain the integrity of the research projects, it is important that the interphase...

  18. Creatvity in Project Work

    DEFF Research Database (Denmark)

    Bjørner, Thomas; Kofoed, Lise B.; Bruun-Pedersen, Jon Ram

    2012-01-01

    that they are creative during all stages in the project work. However, it is also significant that the Medialogy students believe that they are more creative in the beginning of their projects and during the design and implementation stages, whereas the analysis is a less creative part. In general, the Medialogy...

  19. Why Wheels Work.

    Science.gov (United States)

    Stepp, Richard D.

    1982-01-01

    Discusses how the wheel works. The inherent mechanical advantage of wheel-and-axle system is that it reduced the distance the load-bearing surfaces have to slip relative to one another when the whole apparatus advances some given distance reducing (with leverage) the force needed to propel the system. (Author/JN)

  20. Working Group Report: Neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    de Gouvea, A.; Pitts, K.; Scholberg, K.; Zeller, G. P. [et al.

    2013-10-16

    This document represents the response of the Intensity Frontier Neutrino Working Group to the Snowmass charge. We summarize the current status of neutrino physics and identify many exciting future opportunities for studying the properties of neutrinos and for addressing important physics and astrophysics questions with neutrinos.

  1. Information for working mothers.

    Science.gov (United States)

    Montgomery, Kristen S

    2002-01-01

    Women are entering, staying, or returning to the workforce following childbirth in increasing numbers. They report various amounts of success in the workplace after they become mothers. This column presents a review of five Web sites that provide useful resources to working Moms.

  2. Information for Working Mothers

    OpenAIRE

    Montgomery, Kristen S.

    2002-01-01

    Women are entering, staying, or returning to the workforce following childbirth in increasing numbers. They report various amounts of success in the workplace after they become mothers. This column presents a review of five Web sites that provide useful resources to working Moms.

  3. City of open works

    DEFF Research Database (Denmark)

    Riesto, Svava; Søberg, Martin; Braae, Ellen Marie

    2012-01-01

    . These contemporary approaches are closely con-nected to challenges following the transformation of existing urban structures – the re-use of metropolis. And the resulting projects are often created as more or less open works; they challenge existing typologies through a particularly inclusive and hetero...

  4. Empathy in Social Work

    Science.gov (United States)

    Eriksson, Karl; Englander, Magnus

    2017-01-01

    A dominant conceptualization of empathy in social work practice and education, provided by Karen Gerdes and Elizabeth Segal, relies heavily on the simulation theory adopted directly from the cognitive neurosciences. The aim was to critically challenge such a view by reporting on some recent empirical findings from the field in which professional…

  5. Heterogeneity and Work Teams

    Science.gov (United States)

    Dyaram, Lata; Kamalanabhan, T. J.

    2008-01-01

    This paper attempts to extend and contribute to the domestic diversity literature by presenting a comprehensive model that takes into consideration the Indian work set up. It proposes to examine the effects of the composition of information systems development teams in Indian firms. Besides the conventional demographics which were studied…

  6. Working Effectively with Interpreters

    Science.gov (United States)

    Cellitti, Anarella

    2010-01-01

    The United States is becoming increasingly diverse, so early childhood educators are often among the first to work with families whose primary languages are other than English. Many parents, guardians, and family members do speak English but not fluently enough to feel comfortable communicating with teachers or administrators. When educators and…

  7. Writers at Work.

    Science.gov (United States)

    DeSalvo, Louise A.

    1979-01-01

    Argues that educators need to demystify the writing process so that students can approach the world of literature realistically. Suggests that exposure to how writers work and to the kinds of situations from which they draw inspiration can provide insights into what is required of a would-be writer. (FL)

  8. Working Model Hearts

    Science.gov (United States)

    Brock, David

    2009-01-01

    Despite student interest, the heart is often a poorly understood topic in biology. To help students understand this vital organ's physiology, the author created this investigation activity involving the mammalian heart and its role in the circulatory system. Students design, build, and demonstrate working artificial "hearts" to exhibit what they…

  9. Podcasting as Transformative Work

    Science.gov (United States)

    Vasquez, Vivian Maria

    2015-01-01

    Although technology is most often heralded an intrinsic efficiency, the process of using technology to create a text is full of opportunities to learn new information, create and distribute knowledge, and engage in identity work. This article explores how the production of 1 such technological text, a podcast, offered students opportunities to…

  10. Temptation at work

    NARCIS (Netherlands)

    Bucciol, A.; Houser, D.; Piovesan, M.

    2011-01-01

    To encourage worker productivity offices prohibit Internet use. Consequently, many employees delay Internet activity to the end of the workday. Recent work in social psychology, however, suggests that using willpower to delay gratification can negatively impact performance. We report data from an

  11. NASA@Work

    Science.gov (United States)

    Davis, Jeffrey R.

    2014-01-01

    NASA@work is an agency-wide website designed to increase innovation and access to ideas and knowledge from within the NASA community. Individuals (challenge owners) post their specific problem or "challenge." Anyone in the community (solvers) can contribute to the interactive discussions and submit proposed solutions with the opportunity to win an award.

  12. Ways into Work

    Science.gov (United States)

    Morrice, Linda

    2005-01-01

    Refugees with higher qualifications often find themselves under-utilised in the only jobs they can get. A project at the University of Sussex explored refugees' own perceptions of the barriers they face and designed a course to address them. This article discusses the research project which was specifically designed to work with refugees who had…

  13. Gender Inequality at Work.

    Science.gov (United States)

    Jacobs, Jerry A., Ed.

    These 14 papers address many dimensions of gender inequality at work. The empirical studies include examinations of original surveys, secondary analyses of large data sets, and historical reports assaying the significance of personal, family, and structural factors with regard to gender in the workplace. An introduction (Jacobs) sketches how sex…

  14. The work of leadership.

    Science.gov (United States)

    Heifetz, R A; Laurie, D L

    1997-01-01

    More and more companies today are facing adaptive challenges: changes in societies, markets, and technology around the globe are forcing them to clarify their values, develop new strategies, and learn new ways of operating. And the most important task for leaders in the face of such challenges is mobilizing people throughout the organization to do adaptive work. Yet for many senior executives, providing such leadership is difficult. Why? One reason is that they are accustomed to solving problems themselves. Another is that adaptive change is distressing for the people going through it. They need to take on new roles, relationships, values, and approaches to work. Many employees are ambivalent about the sacrifices required of them and look to senior executives to take problems off their shoulders. But both sets of expectations have to be unlearned. Rather than providing answers, leaders have to ask tough questions. Rather than protecting people from outside threats, leaders should let the pinch of reality stimulate them to adapt. Instead of orienting people to their current roles, leaders must disorient them so that new relationships can develop. Instead of quelling conflict, leaders should draw the issues out. Instead of maintaining norms, leaders must challenge "the way we do business" and help others distinguish immutable values from the historical practices that have become obsolete. The authors offer six principles for leading adaptive work: "getting on the balcony," identifying the adaptive challenge, regulating distress, maintaining disciplined attention, giving the work back to people, and protecting voices of leadership from below.

  15. Better Work Environments.

    Science.gov (United States)

    Murray, Chris

    2002-01-01

    Looks at equipment, process, and training aspects of backpack vacuum cleaners that facilitate good ergonomics and high productivity levels, focusing on: designing new equipment for bodies and productivity; creating comfortable backpack harnesses; improving the work process via team training; and providing ergonomic training to ensure that backpack…

  16. Working on the environment

    NARCIS (Netherlands)

    Ruepert, Angela Maria

    2016-01-01

    Organizations increasingly recognize that environmental problems will reduce if their employees would act more pro-environmentally, but struggle with the question how to realise this. This PhD project shows that employees act more pro-environmentally at work when they care about the environment, and

  17. High Performance Work Systems

    NARCIS (Netherlands)

    J.P.P.E.F. Boselie (Paul); A. van der Wiele (Ton)

    2002-01-01

    textabstractResearch, summarized and classified in the work of Delery and Doty (1996), Guest (1997), Paauwe and Richardson (1997) and Boselie et al. (2001), suggests significant impact of Human Resources Management (HRM) on the competitive advantage of organizations. The mainstream research on this

  18. Working in the Cold

    Centers for Disease Control (CDC) Podcasts

    2016-02-08

    During the winter, many workers are outdoors, working in cold, wet, icy, or snowy conditions. Learn how to identify symptoms that tell you there may be a problem and protect yourself from cold stress.  Created: 2/8/2016 by National Institute for Occupational Safety and Health (NIOSH).   Date Released: 2/8/2016.

  19. Third Year work

    OpenAIRE

    Durrant, Adam

    2008-01-01

    A pavilion based in Reaseheath College's woodland walk. Built for the discussion and exhibition of work involving combination of organic 'grow your own architecture' materials with man-made synthetic materials which may offer some benefits organics cannot such as u-values etc... The subject matter falls under 'living architecture'.

  20. Work and leisure

    National Research Council Canada - National Science Library

    Veal, Anthony James; Haworth, John Trevor

    2004-01-01

    ... and quality of life in the spotlight. Profound transformations in the nature and organisation of work are occurring, with potentially far-reaching social and economic consequences. Increasingly, organisations demand greater flexibility from their workforces and are introducing new technologies and practices in response to global competitive pres...

  1. Working Women: Indian Perspective

    Directory of Open Access Journals (Sweden)

    Dharmendra MEHTA

    2014-06-01

    Full Text Available In India, due to unprecedented rise in the cost of living, ris-ing prices of commodities, growing expenses on children ed-ucation, huge rate of unemployment, and increasing cost of housing properties compel every Indian family to explore all the possible ways and means to increase the household income. It is also witnessed that after globalization Indian women are able to get more jobs but the work they get is more casual in nature or is the one that men do not prefer to do or is left by them to move to higher or better jobs. Working women refers to those in paid employment. They work as lawyers, nurses, doctors, teachers and secretaries etc. There is no profession today where women are not employed. University of Oxford’s Professor Linda Scott recently coined the term the Double X Economy to describe the global economy of women. The present paper makes an attempt to discuss issues and challenges that are being faced by Indian working women at their respective workstations.

  2. Change through Group Work.

    Science.gov (United States)

    McAllan, Les; Friedman, Amy; Spears, Evans

    Perhaps the most well known treatment modalities in the field of prevention and treatment of addiction are groups. Group settings serve to bring individuals with addictions together at one time in one place to work on relevant issues together. Groups may serve as a safe environment for learning new social and relationship skills, gaining…

  3. Doing Home Works

    DEFF Research Database (Denmark)

    Nelund, Sidsel

    2013-01-01

    of aesthetic analysis of artworks and ethnographic fieldwork (Georgina Born); and 3) the use of generative ethnographic stories as a writing tool (Helen Verran). The latter two, especially, are then employed in analysing the Beirut-based extended exhibition, ‘Home Works: A Forum on Cultural Practices...

  4. Working during cancer treatment

    Science.gov (United States)

    ... weekend to recover. Talk to your manager about working at home some days, if possible. You can spend less time commuting and rest when you need to. Let your boss know your treatment schedule ... out if you have to be out of the office. Consider talking first to one or two people ...

  5. Quantifiers and working memory

    NARCIS (Netherlands)

    Szymanik, J.; Zajenkowski, M.

    2010-01-01

    The paper presents a study examining the role of working memory in quantifier verification. We created situations similar to the span task to compare numerical quantifiers of low and high rank, parity quantifiers and proportional quantifiers. The results enrich and support the data obtained

  6. Academic Work and Performativity

    Science.gov (United States)

    Kenny, John

    2017-01-01

    Neoliberal reforms in higher education have resulted in corporate managerial practices in universities and a drive for efficiency and productivity in teaching and research. As a result, there has been an intensification of academic work, increased stress for academics and an emphasis on accountability and performativity in universities. This paper…

  7. The Work Ethic Game.

    Science.gov (United States)

    Nelson, Kate

    1992-01-01

    Describes the development of "The Work Ethic Game" that focuses on integrity in the workplace. Explains that the game is divided into three categories: legal, judgment, and policy issues. Discusses different personality types in the typical employee population. Includes possibilities for use at different education levels. (DK)

  8. Stay Safe at Work

    Science.gov (United States)

    ... over again, like typing or working on an assembly line. This can lead to a type of ... Privacy Policy Site Map Viewers & Players Contact Us Language Assistance Available Español 繁體中文 Tiếng Việt 한국어 Français ...

  9. Farm Women and Work.

    Science.gov (United States)

    Sander, William

    1986-01-01

    The participation by farm women in on-farm and off-farm work is estimated and the effects of female earnings on farm family income are measured. It is shown that farm women make significant contributions to income and help manage income instability. (Author/CH)

  10. Measuring innovative work behaviour

    NARCIS (Netherlands)

    de Jong, J.; den Hartog, D.

    2010-01-01

    Both scientists and practitioners emphasize the importance of innovative work behaviour (IWB) of individual employees for organizational success, but the measurement of IWB is still at an evolutionary stage. This article is concerned with developed a measure of IWB with four potential dimensions:

  11. IPD-Work consortium

    DEFF Research Database (Denmark)

    Kivimäki, Mika; Singh-Manoux, Archana; Virtanen, Marianna

    2015-01-01

    underestimation of the population attributable risk (PAR) of job strain for CHD, and policy implications arising from the findings of the IPD-Work consortium; and (iii) outline general principles for designing evidence-based policy and prevention from good-quality evidence, including future directions...

  12. Academic Work and Performance

    Science.gov (United States)

    Gunter, Helen M.

    2012-01-01

    Reading current accounts of higher education demonstrates the flux and damage of rapid neoliberal changes to the type and conduct of academic work. Opening the Times Higher Education magazine on the 28 April 2011 shows articles about cuts in staffing and undergraduate provision in England, concerns about the quality of for-profit higher education…

  13. Situated Literacies at Work.

    Science.gov (United States)

    Searle, Jean

    2002-01-01

    Gathered data about work practices related to three motels and two eco-tourism sites. Findings suggest that actual workplace practices involve socially constructed literacies depending on the user's ability to make judgments on using the text or obtaining information from the text. (SLD)

  14. Working as a Team

    Science.gov (United States)

    Brooks, Hannah

    2017-01-01

    In most STEM industries, teamwork is essential. Engineers, scientists, statisticians, and medical professionals, for example, must communicate with one another and work together. Someday, students may enter the STEM (science, technology, engineering, and math) workforce, where they also will need to collaborate effectively. This article describes…

  15. Know When Antibiotics Work

    Centers for Disease Control (CDC) Podcasts

    2015-04-15

    This podcast provides a brief background about antibiotics and quick tips to help prevent antibiotic resistance.  Created: 4/15/2015 by Division of Bacterial Diseases (DBD), National Center for Immunization and Respiratory Disease (NCIRD), Get Smart: Know When Antibiotics Work Program.   Date Released: 4/16/2015.

  16. Facilities removal working group

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This working group`s first objective is to identify major economic, technical, and regulatory constraints on operator practices and decisions relevant to offshore facilities removal. Then, the group will try to make recommendations as to regulatory and policy adjustments, additional research, or process improvements and/or technological advances, that may be needed to improve the efficiency and effectiveness of the removal process. The working group will focus primarily on issues dealing with Gulf of Mexico platform abandonments. In order to make the working group sessions as productive as possible, the Facilities Removal Working Group will focus on three topics that address a majority of the concerns and/or constraints relevant to facilities removal. The three areas are: (1) Explosive Severing and its Impact on Marine Life, (2) Pile and Conductor Severing, and (3) Deep Water Abandonments This paper will outline the current state of practice in the offshore industry, identifying current regulations and specific issues encountered when addressing each of the three main topics above. The intent of the paper is to highlight potential issues for panel discussion, not to provide a detailed review of all data relevant to the topic. Before each panel discussion, key speakers will review data and information to facilitate development and discussion of the main issues of each topic. Please refer to the attached agenda for the workshop format, key speakers, presentation topics, and panel participants. The goal of the panel discussions is to identify key issues for each of the three topics above. The working group will also make recommendations on how to proceed on these key issues.

  17. Plasmacytoid dendritic cell proliferations and neoplasms involving the bone marrow : Summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016.

    Science.gov (United States)

    Tzankov, Alexandar; Hebeda, Konnie; Kremer, Markus; Leguit, Roos; Orazi, Attilio; van der Walt, Jon; Gianelli, Umberto

    2017-05-01

    Two distinct forms of neoplasms derived from plasmacytoid dendritic cells (PDC) exist: mature PDC proliferations associated with myeloid neoplasms and blastic PDC neoplasms (BPDCN). Ten cases of PDC proliferations and neoplasms in the bone marrow have been submitted to the bone marrow workshop held at the 18th EAHP meeting. Based on observations from the submitted cases, scattered PDC (≤1% of cells) and PDC aggregates (≤10 PDC/HPF) reflect the normal bone marrow composition, while in myelodysplastic syndromes (MDS), there is a propensity for larger/more PDC aggregates (1-5% and 35 PDC/HPF). A shared PTPN11 mutation between a mature PDC proliferation and an accompanying MDS provides evidence of clonal relationship in such instances and shows that PDC are a part of the malignant clone. CD123 and CD303 should be considered backbone markers to histopathologically establish the diagnosis of BPDCN, since they are detectable in almost all cases and properly well on biopsies subjected to different fixations. Expression of some T-cell markers (e.g., CD2 and CD7 but not CD3), B-cell markers (e.g., CD79a but not CD19 and CD20), and myeloid markers (e.g., CD33 and CD117 but not myeloperoxidase) can be observed in BPDCN. Genetical data of the summarized cases corroborate the important role of chromosomal losses in BPDCN. Together with five previously reported instances, one additional workshop case with MYC rearrangement proposes that translocations of MYC may be recurrent. The frequent nature of deleterious mutations of IKZF3 and deletions of IKZF1 suggests a role for the Ikaros family proteins in BPDCN.

  18. The Director's Work on Himself

    DEFF Research Database (Denmark)

    Kuhlmann, Annelis

    2008-01-01

    A reading of Stanislavsky's major works about the actor's work on himself from the viewpoint of the director's work on himself.......A reading of Stanislavsky's major works about the actor's work on himself from the viewpoint of the director's work on himself....

  19. Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years’ experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases

    Science.gov (United States)

    Farge, Dominique; Labopin, Myriam; Tyndall, Alan; Fassas, Athanasios; Mancardi, Gian Luigi; Van Laar, Jaap; Ouyang, Jian; Kozak, Tomas; Moore, John; Kötter, Ina; Chesnel, Virginie; Marmont, Alberto; Gratwohl, Alois; Saccardi, Riccardo

    2010-01-01

    Background Autologous hematopoietic stem cell transplantation has been used since 1996 for the treatment of severe autoimmune diseases refractory to approved therapies. We evaluated the long-term outcomes of these transplants and aimed to identify potential prognostic factors. Design and Methods In this observational study we analyzed all first autologous hematopoietic stem cell transplants for autoimmune diseases reported to the European Group for Blood and Marrow Transplantation (EBMT) registry between 1996–2007. The primary end-points for analysis were overall survival, progression-free survival and transplant-related mortality at 100 days. Results Nine hundred patients with autoimmune diseases (64% female; median age, 35 years) who underwent a first autologous hematopoietic stem cell transplant were included. The main diseases were multiple sclerosis (n=345), systemic sclerosis (n=175), systemic lupus erythematosus (n=85), rheumatoid arthritis (n=89), juvenile arthritis (n=65), and hematologic immune cytopenia (n=37). Among all patients, the 5-year survival was 85% and the progression-free survival 43%, although the rates varied widely according to the type of autoimmune disease. By multivariate analysis, the 100-day transplant-related mortality was associated with the transplant centers’ experience (P=0.003) and type of autoimmune disease (P=0.03). No significant influence of transplant technique was identified. Age less than 35 years (P=0.004), transplantation after 2000 (P=0.0015) and diagnosis (P=0.0007) were associated with progression-free survival. Conclusions This largest cohort studied worldwide shows that autologous hematopoietic stem cell transplantation can induce sustained remissions for more than 5 years in patients with severe autoimmune diseases refractory to conventional therapy. The type of autoimmune disease, rather than transplant technique, was the most relevant determinant of outcome. Results improved with time and were associated with

  20. While working around security

    DEFF Research Database (Denmark)

    Mathiasen, Niels Raabjerg; Bødker, Susanne; Petersen, Marianne Graves

    This paper describes our work at two levels. First of all the paper discusses how users of IT deal with issues of IT security in their everyday life. Secondly, we discuss how the kind of understanding of IT security that comes out of careful analyses of use confronts the ways in which usable...... IT security is established in the literature. Recent literature has called for better conceptual models as a starting point for improving IT security. In contrast to such models we propose to dress up designers by helping them better understand the work that goes into everyday security. The result...... is a methodological toolbox that helps address and design for usable and useful IT security. We deploy examples of analyses and design, carried out by ourselves and by others to fine-tune our design perspective; in particular we use examples from three current research projects....

  1. Progression in work readiness

    DEFF Research Database (Denmark)

    Jensen, Sophie Danneris

    2013-01-01

    in social work programs (amongst others Boaz & Blewett 2010 and Koivisto 2008). Initially there will be a short presentation of the research topic of my Ph.D. and the central research question related to the project. Following this is a methodological discussion in two levels - the first discussion......This paper is based partly on literature concerning the construction of identities in social work settings (especially Juhila & Abrams 2011, Eskelinen & Olesen 2010) and partly on literature that addresses the dilemmas and challenges in providing evidence about the effectiveness of interventions...... at a meta level, where the problems concerning evidence, measurements of effects and how to improve interventions and practice will be addressed. At the second, micro level, the discussion will be about the specific data collection methods in the project and how the identities of the clients can...

  2. "We work on experiments"

    CERN Multimedia

    BBC

    1975-01-01

    Short BBC (?) report on CERN. Emphasis on international collaboration, with Soviets and Chinese highlighted. At end, interview with Danish physicist (our of sync) who talks about working on Sundays and how experiments have 25 people, therefore it is a long way to glory. ISR. Comments: Film scratched and dirty. Colour pink. Looses sync at the end. Video transfer ends before the end of the film.

  3. Tram works (TCMC)

    CERN Multimedia

    GS Department

    2011-01-01

    In order to allow the final switchover of traffic, as part of the on-going Tram works (TCMC), please note that the traffic lights at Entrance B will be out of service from 7 to 14 February. In order to ensure traffic safety and allow CERN employees to exit the site, a temporary roundabout will be installed during this week. Department of General Infrastructure Services (GS) GS-SE Group

  4. Multibunch working group

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The goal of this working group was to foment discussions about the use and limitations of multi-bunch, representatives from most operating or in-project synchrotron radiation sources (ALS, SPEAR, BESSY-2, SPRING-8, ANKA, DELTA, PEP-2, DIAMOND, ESRF...) have presented their experience. The discussions have been led around 3 topics: 1) resistive wall instabilities and ion instabilities, 2) higher harmonic cavities, and 3) multibunch feedback systems.

  5. WORK AND LEARNER IDENTITY

    DEFF Research Database (Denmark)

    Kondrup, Sissel

    2015-01-01

    The aim of this article is to suggest a theoretical framework than can assess to how people’s engagement in specific historical and social work practices are significant to their development, maintenance or transformation of a learner identity. Such a framework is crucial in order to grasp how di...... different groups have distinctive conditions for meeting the obligation of forming a proactive learner identity and engage in lifelong learning prevalent in both national and transnational policies on lifelong learning....

  6. Abandoning wells working group

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The primary objective of this working group is to identify major technical, regulatory, and environmental issues that are relevant to the abandonment of offshore wellbores. Once the issues have been identified, the working group also has the objective of making recommendations or providing potential solutions for consideration. Areas for process improvement will be identified and {open_quotes}best practices{close_quotes} will be discussed and compared to {open_quotes}minimum standards.{close_quotes} The working group will primarily focus on wellbore abandonment in the Gulf of Mexico. However, workshop participants are encouraged to discuss international issues which may be relevant to wellbore abandonment practices in the Gulf of Mexico. The Abandoning Wells Group has identified several major areas for discussion that have concerns related to both operators and service companies performing wellbore abandonments in the Gulf of Mexico. The following broad topics were selected for the agenda: (1) MMS minimum requirements and state regulations. (2) Co-existence of best practices, new technology, and P & A economics. (3) Liability and environmental issues relating to wellbore abandonment.

  7. Gender and Working Life

    Directory of Open Access Journals (Sweden)

    Tapio Bergholm

    2011-11-01

    Full Text Available Analysis of occupational segregation by sex and gendered practices in the workplace are complex, multidimensional and contested fields of research and academic discourse. Since the 1960s, we have seen a rapid growth in both quantity and quality of academic work in this field. Earlier simplistic main (male stream as well as straightforward feminist explanations has been roundly criticised and deconstructed. It is now clear that the study of gender relations in working life is far more complicated than it was believed decades ago. The central question in gender research is how gendered structures – in which men in general have more power, more prestigious positions and higher pay – are reproduced in a world in which demography, economy, production, education and therefore society and family have changed over time. Nordic countries represents an interesting geographical arena to examine gender relations in working life, because many factors, which have been seen in other countries as causes for female subordination, appear in other forms. At present, the labour force participation rate of women in Nordic countries is nearly equal to that of men, but there are still substantial differences. Women are better educated than men, and also, to a large extent unionised. Although these factors make Nordic women stand out globally, gender equality at work or at home has not yet been achieved. The male breadwinner is still a societal norm and a construct, which conditions the behaviour of organisations and individuals in many circumstances in working life. This influence can be obvious or obscure. From the 1990s, research has turned to focus also on the fate of the male workforce during deindustrialisation and global restructuring. Participation rate of men in gainful employment have diminished in all industrialised countries (Crouch; 1999, Walby; 1997. Nordic countries are not an exception to this trend. Men’s difficulties to adapt to a new service

  8. NASA Work Experience

    Science.gov (United States)

    Frandsen, Athela F.

    2015-01-01

    I have had the opportunity to support the analytical laboratories in chemical analysis of unknown samples, using Optical Microscopy (OM), Polarizing Light Microscopy (PLM), Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEMEDS), and X-ray Powder Diffraction (XPD). I have assisted in characterizing fibers pulled from a spacecraft, a white fibrous residue discovered in a jet refueler truck, brown residue from a plant habitat slated for delivery to the ISS (International Space Station), corrosion on a pipe from a sprinkler, and air filtration material brought back from the ISS. I also conducted my own fiber study in order to practice techniques and further my understanding of background concepts. Furthermore, I had the opportunity to participate in diverse work assignments, where I was assigned to work with other branches of the engineering department for 1-2 days each. The first was in the Materials Science branch where I participated in the construction of the plant habitat intended for use in research aboard the ISS. The second was in the Testing Design branch where I assisted with tensile and hardness testing of over 40 samples. In addition, I have had the privilege to attend multiple tours of the NASA KSC campus, including to the Astronaut Crew Quarters, the VAB (the main area, the Columbia room, and the catwalk), the Visitor Center housing the shuttle Atlantis, the Saturn-V exhibit, the Prototype laboratory, SWAMP WORKS, the Shuttle Landing Facility, the Crawler, and the Booster Fabrication Facility (BFF). Lastly, much of my coursework prepared me for this experience, including numerous laboratory courses with topics diverse as chemistry, physics, and biology.

  9. The works of archimedes

    CERN Document Server

    Archimedes

    2002-01-01

    The complete works of antiquity's great geometer appear here in a highly accessible English translation by a distinguished scholar. Remarkable for his range of thought and his mastery of treatment, Archimedes addressed such topics as the famous problems of the ratio of the areas of a cylinder and an inscribed sphere; the measurement of a circle; the properties of conoids, spheroids, and spirals; and the quadrature of the parabola. This edition offers an informative introduction with many valuable insights into the ancient mathematician's life and thought as well as the views of his contemporar

  10. MPD work at MIT

    Science.gov (United States)

    Martinez-Sanchez, Manuel

    1991-01-01

    MPD work at MIT is presented in the form of the view-graphs. The following subject areas are covered: the MIT program, its goals, achievements, and roadblocks; quasi one-dimensional modeling; two-dimensional modeling - transport effects and Hall effect; microscopic instabilities in MPD flows and modified two stream instability; electrothermal stability theory; separation of onset and anode depletion; exit plane spectroscopic measurements; phenomena of onset as performance limiter; explanations of onset; geometry effects on onset; onset at full ionization and its consequences; relationship to anode depletion; summary on self-field MPD; applied field MPD - the logical growth path; the case for AF; the challenges of AF MPD; and recommendations.

  11. Art/Net/Work

    DEFF Research Database (Denmark)

    Andersen, Christian Ulrik; Lindstrøm, Hanne

    2006-01-01

    The seminar Art|Net|Work deals with two important changes in our culture. On one side, the network has become essential in the latest technological development. The Internet has entered a new phase, Web 2.0, including the occurrence of as ‘Wiki’s’, ‘Peer-2-Peer’ distribution, user controlled...... the praxis of the artist. We see different kinds of interventions and activism (including ‘hacktivism’) using the network as a way of questioning the invisible rules that govern public and semi-public spaces. Who ‘owns’ them? What kind of social relationships do they generate? On what principle...

  12. Outsourcing of experimental work.

    Science.gov (United States)

    Nielsen, Henrik

    2011-01-01

    With the development of new technologies for simultaneous analysis of many genes, transcripts, or proteins (the "omics" revolution), it has become common to outsource parts of the experimental work. In order to maintain the integrity of the research projects, it is important that the interphase between the researcher and the service is further developed. This involves robust protocols for sample preparation, an informed choice of analytical tool, development of standards for individual technologies, and transparent data analysis. This chapter introduces some of the problems related to analysis of RNA samples in the "omics" context and gives a few hints and key references related to sample preparation for the non-specialist.

  13. Fit for work

    DEFF Research Database (Denmark)

    Brorholt, Grete

    "Fit for work - Attraktiv sundhed og sikkerhed på en hospitalsafdeling i Region Hovedstaden" undersøger hvorledes sundhedsvæsenets forandringer påvirker medarbejdere, ledere og organisation. Udgangspunktet for afhandlingen er en interesse for psykisk arbejdsmiljø, og hvordan reformerne i kølvandet...... vidensvirksomhed i konkurrencestaten. Afhandlingen undersøger, hvordan disse policy-forandringer peger i retning af et bestemt styringsrationale — en ‘sundhedsorden’— som fremskriver en bestemt medarbejder- figur, hvori medarbejdere og ledere forventes at engagere og udfolde sig i et udfordrende og attraktivt, men...

  14. Temptation at work

    DEFF Research Database (Denmark)

    Bucciol, Alessandro; Houser, Daniel; Piovesan, Marco

    2013-01-01

    To encourage worker productivity, companies routinely adopt policies requiring employees to delay gratification. For example, offices might prohibit use of the internet for personal purposes during regular business hours. Recent work in social psychology, however, suggests that using willpower...... to delay gratification can negatively impact performance. We report data from an experiment where subjects in a Willpower Treatment are asked to resist the temptation to join others in watching a humorous video for 10 minutes. In relation to a baseline treatment that does not require willpower, we show...

  15. Mac at Work

    CERN Document Server

    Sparks, David

    2011-01-01

    Bridge the gap between using a Mac at home and at the office. Now that you love your Mac at home, you want to use one at the office without missing a beat of productivity or professionalism. This unique guide shows you how.  You'll find best Mac business practices for handling word processing, spreadsheet and presentation creation, task and project management, and graphics. The book also explores topics such as hardware maintenance, how to synchronize with multiple computers, data backup, and communication with Windows networks.: Covers the nuts and bolts of using a Mac at work, including sync

  16. Working Women: Indian Perspective

    OpenAIRE

    Dharmendra MEHTA; Naveen K MEHTA; Rajesh Kumar MEHTA

    2014-01-01

    In India, due to unprecedented rise in the cost of living, ris-ing prices of commodities, growing expenses on children ed-ucation, huge rate of unemployment, and increasing cost of housing properties compel every Indian family to explore all the possible ways and means to increase the household income. It is also witnessed that after globalization Indian women are able to get more jobs but the work they get is more casual in nature or is the one that men do not prefer to do or is left by them...

  17. Human Work Interaction Design

    DEFF Research Database (Denmark)

    Gonçalves, Frederica; Campos, Pedro; Clemmensen, Torkil

    2015-01-01

    In this paper, we review research in the emerging practice and research field of Human Work Interaction Design (HWID). We present a HWID framework, and a sample of 54 HWID related papers from workshops, conferences and journals from the period 2009–2014. We group the papers into six topical groups....... Furthermore, much focus has been on studying design sketching or implemented systems-in-use, while little attention has been paid to mature design (prototypes) or early implementation (content templates). In conclusion, we recommend an update to the framework so that it can be also useful for research...

  18. Temptation at work.

    Directory of Open Access Journals (Sweden)

    Alessandro Bucciol

    Full Text Available To encourage worker productivity, companies routinely adopt policies requiring employees to delay gratification. For example, offices might prohibit use of the internet for personal purposes during regular business hours. Recent work in social psychology, however, suggests that using willpower to delay gratification can negatively impact performance. We report data from an experiment where subjects in a Willpower Treatment are asked to resist the temptation to join others in watching a humorous video for 10 minutes. In relation to a baseline treatment that does not require willpower, we show that resisting this temptation detrimentally impacts economic productivity on a subsequent task.

  19. Nanostructured Organic Solar Cells

    DEFF Research Database (Denmark)

    Radziwon, Michal Jędrzej; Rubahn, Horst-Günter; Madsen, Morten

    Recent forecasts for alternative energy generation predict emerging importance of supporting state of art photovoltaic solar cells with their organic equivalents. Despite their significantly lower efficiency, number of application niches are suitable for organic solar cells. This work reveals...... the principles of bulk heterojunction organic solar cells fabrication as well as summarises major differences in physics of their operation....

  20. A working Christmas

    CERN Multimedia

    2005-01-01

    The repair of faulty elements in the cryogenic distribution line is making great progress in building 927 at CERN. While many of us were relaxing over the two-week Christmas break, the team repairing elements of the LHC cryogenic distribution line - or QRL - continued working, keeping the repair schedule on course for completion by the end of March. Pipe elements with faulty sliding tables are being repaired by the ICS consortium, in charge of installing the cryo-magnets in their cryostats. This team began repairs at the beginning of November, fixing 10 elements a week (See Bulletin 42/2004 from 11 October 2004). However, during the five-week winter shutdown of the magnet test facility they are being assisted by 20 personnel who normally work on magnet testing. With the extra help a repair rate of five pipe elements a day has been reached - 25 elements a week - thanks to the remarkable effort of the ICS personnel led by Patrick Voisin, the DBS personnel assuring the transport and handling of the elements, an...

  1. Automatization of lexicographic work

    Directory of Open Access Journals (Sweden)

    Iztok Kosem

    2013-12-01

    Full Text Available A new approach to lexicographic work, in which the lexicographer is seen more as a validator of the choices made by computer, was recently envisaged by Rundell and Kilgarriff (2011. In this paper, we describe an experiment using such an approach during the creation of Slovene Lexical Database (Gantar, Krek, 2011. The corpus data, i.e. grammatical relations, collocations, examples, and grammatical labels, were automatically extracted from 1,18-billion-word Gigafida corpus of Slovene. The evaluation of the extracted data consisted of making a comparison between the time spent writing a manual entry and a (semi-automatic entry, and identifying potential improvements in the extraction algorithm and in the presentation of data. An important finding was that the automatic approach was far more effective than the manual approach, without any significant loss of information. Based on our experience, we would propose a slightly revised version of the approach envisaged by Rundell and Kilgarriff in which the validation of data is left to lower-level linguists or crowd-sourcing, whereas high-level tasks such as meaning description remain the domain of lexicographers. Such an approach indeed reduces the scope of lexicographer’s work, however it also results in the ability of bringing the content to the users more quickly.

  2. Effects on the work of a direct ethanol fuel cell as function of compacting force applied to the cell; Efeitos no funcionamento de uma celula a combustivel com alimentacao direta de etanol (CCADE) em funcao da forca de compactacao aplicada a celula

    Energy Technology Data Exchange (ETDEWEB)

    Belchior, P.M.; Forte, M.M.C. [UFRGS - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil); Serafin, R.; Fusiger, V.; Carpenter, D. [FURB - Fundacao Universidade Regional de Blumenau, SC (Brazil)

    2010-07-01

    This experiment aimed to verify the influence due to the variation of the compacting force applied to a DEFC. According to the tests, as the increase of cell compacting, the performance improves significantly. According applied tests, when the high electrical conductivity components are used, small differences of the cell compacting can generate a large difference on the total ohmic resistance. Through the tests one can conclude that with the increase of cell compacting, the contact probably increase among the distribution of reagents and the diffuser layer, improving the cell performance. (author)

  3. Do Microfractures Work?

    Directory of Open Access Journals (Sweden)

    Prejbeanu Radu

    2016-11-01

    Full Text Available It has been observed that injuries, which involve only a part of the joint cartilage thickness, show a partial healing ability, but some healing potential is present in the case of injuries that affect the subchondral osseous tissue. The methods of treatment for chondral defects are nonsurgical: pharmacological chondroprotection (nutraceuticals containing chondroitin sulphate and glucosamine sulphate, viscosupplementation, PRP and cytokine modulation. The surgical options include palliative approaches, marrow stimulation, and cell-based regeneration techniques. The microfracturing technique has started to be used in the ’80s using equine models. The basic principle of microfracturing is to stimulate cartilage repair, not regeneration. It represents the first line of therapy for cartilage defects that affect its full thickness. The advantages of microfracturing are: it is a minimally invasive procedure, technical simplicity, decreased surgical morbidity, and low costs, thus making it a common procedure. However, microfracturing is not a bulletproof technique. There is a high rate of treatment failure after 5 years. Constant decline of the outcome during the 5-year follow-up after surgery is also described. Lesion size represents a better predictor regarding outcome, compared to age. The best results are obtained in young patients, small lesions and low-demand patients. Microfractures can be augmented using BMAC (bone marrow aspirate concentrate containing 0-0.1% progenitor cells. The matrix aids in the improvement of microfractures, and it also increases the stability of the blood clot, acting as a barrier that avoids the fibroblast invasion of the graft. There is still a place for microfractures in chondral defects. Better results can be achieved with an improved technique, an optimized rehabilitation, and adding several augmentation techniques.

  4. While Working Around Security

    DEFF Research Database (Denmark)

    Mathiasen, Niels Raabjerg

    Users of technology encounter various IT security mechanisms in their everyday lives. If these mechanisms fail to support everyday activities, they either get in the way, or the users find a way to work around them. Even though users manage to carry out everyday activities by using substandard...... IT security mechanisms or via workarounds, it will influence their experience of security. If researchers and designers only focus on IT security artifacts and fail to take the user experience into account, incorrect processes or workarounds will occur. Accordingly, to get users to follow the correct process...... may seem to be a criterion of success, even though it may yield a less appropriate experience of security. This dissertation deals with an improved understanding of IT security sensitive IT artifacts and presents three design methods, and a framework for addressing the complexities and contingencies...

  5. Swamp Works- Multiple Projects

    Science.gov (United States)

    Carelli, Jonathan M.; Schuler, Jason M.; Chandler, Meredith L.

    2013-01-01

    My Surface Systems internship over the summer 2013 session covered a broad range of projects that utilized multiple fields of engineering and technology. This internship included a project to create a command center for a 120 ton regolith bin, for the design and assembly of a blast shield to add further protection for the Surface Systems engineers, for the design and assembly of a portable four monitor hyper wall strip that could extend as large as needed, research and programming a nano drill that could be utilized on a next generation robot or rover, and social media tasks including the making of videos, posting to social networking websites and creation of a new outreach program to help spread the word about the Swamp Works laboratory.

  6. Aggression at Work

    DEFF Research Database (Denmark)

    Høgh, Annie

    response in victims. It was also an aim of the thesis to study whether aspects of the work environment, social climate and personal dispositions would mediate potential relationships between exposure to bullying, nasty teasing or violence and different health effects and stress reactions.      The study...... symptoms and a lower physiological stress response. Gender differences in health effects were focused on specifically and reported for exposure to nasty teasing. The results are discussed and different explanations are suggested.      Victims of bullying and nasty teasing reported lower support from co...... as a mediator of the relationships between violence and different stress-reactions. Negative affectivity acted as a partial mediator between being bullied and different health effects.      Thus, the longitudinal studies showed that exposure to nasty teasing predicted fatigue in women five years later...

  7. Working Group Report: Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Artuso, M.; et al.,

    2013-10-18

    Sensors play a key role in detecting both charged particles and photons for all three frontiers in Particle Physics. The signals from an individual sensor that can be used include ionization deposited, phonons created, or light emitted from excitations of the material. The individual sensors are then typically arrayed for detection of individual particles or groups of particles. Mounting of new, ever higher performance experiments, often depend on advances in sensors in a range of performance characteristics. These performance metrics can include position resolution for passing particles, time resolution on particles impacting the sensor, and overall rate capabilities. In addition the feasible detector area and cost frequently provides a limit to what can be built and therefore is often another area where improvements are important. Finally, radiation tolerance is becoming a requirement in a broad array of devices. We present a status report on a broad category of sensors, including challenges for the future and work in progress to solve those challenges.

  8. On the Work Itself

    DEFF Research Database (Denmark)

    Vikkelsø, Signe

    ’ of organizational life. A widespread argument for this decreased significance holds that it is no longer relevant to speak in terms of overarching purposes as organizations manoeuvre in rapidly changing environments where tasks and purposes are multiple, ambiguous and in flux. Another is that the definition...... and illustrate the problems of bewilderment and fragmentation arising from neglecting the issue. A bewilderment and fragmentation that also characterises contemporary organization theory as a discipline, I argue. Employing the notion of ‘reality device’ I conclude that understanding the core tasks...... of an organization is an indispensable means to register and evaluate the empirical reality of organizations and the work to be done in order to accomplish those tasks....

  9. Working environment interventions

    DEFF Research Database (Denmark)

    Hasle, Peter; Limborg, Hans Jørgen; Nielsen, Klaus T.

    2014-01-01

    is paid to why and how public and private organisations subsequently are to improve their working environment. This paper suggests a model which can bridge this gap. It is based on a combination of theories about basic policy instruments (regulation, incentives and information) with realistic analysis...... analysis of the case shows how various actors, including the authorities, employers, unions and bi-partite committees, developed a programme combining the policy instruments over a considerable period of time and that all three institutional mechanisms affected the outcome. This integration of various......, and the importance of joint messages from employers and unions. The model thus provides new insights into the relationship between policy instruments and workplace health and safety outcomes...

  10. Humboldt's works on Mexico

    Directory of Open Access Journals (Sweden)

    Ulrike Leitner

    2000-10-01

    Full Text Available Article in English, Abstracts in Spanish and English. Humboldt wrote about Mexico from the perspective of a scientific explorer and naturalist. His works include his diaries, the Essai politique sur le royaume de la Nouvelle-Espagne, the Tablas géograficas, the Vues des Cordillères and a geographic atlas. Concerning the scientific aspect, the lack of a section on Mexico in the Relation historique is not a real deficit, since this can be found in the Essai. But only the diaries and letters from the journey, both published by the Alexander-von-Humboldt Research Centre, Berlin, can be considered an adequate substitute.The following will show the origin of Humboldt's writings on Mexico, offer historical and bibliographical facts and present the publications "Beiträge zur Alexander von Humboldt-Forschung", as well as Humboldt’s handwritten estate as far as they are available to us.

  11. Working Environment and Technological Development

    DEFF Research Database (Denmark)

    Clausen, Christian; Nielsen, Klaus T.; Jensen, Per Langaa

    1997-01-01

    The paper describes the purpose, themes, overarching research questions and specific projects of the programme: Working Environment and Technological Development. The major research themes are:1) Management concepts and the working environment, which considers the visions...... and their and their concept of working environment2) Technology renewal, which considers the role of the working environment in connection with the development and use of concrete technologies3) Working environment planning, which considers the existing efforts to place the working environment in a planning process....

  12. Decent Work: A Psychological Perspective

    OpenAIRE

    David eBlustein; Chad eOlle; Alice eConnors-Kellgren; AJ eDiamonti

    2016-01-01

    This contribution, which serves as the lead article for the Research Section entitled From Meaning of Working to Meaningful Lives: The Challenges of Expanding Decent Work, explores current challenges in the development and operationalization of decent work. Based on an initiative from the International Labor Organization (ILO; 1999), decent work represents an aspirational statement about the quality of work that should be available to all people who seek to work around the globe. Within rece...

  13. Work Zone Data Collection Trailer

    Data.gov (United States)

    Federal Laboratory Consortium — The Work Zone Data Collection Trailer was designed and constructed to enhance data collection and analysis capabilities for the "Evaluating Roadway Construction Work...

  14. Exploring Work Values: Helping Students Articulate Their Good (Work) Life

    Science.gov (United States)

    Carlstrom, Aaron H.; Hughey, Kenneth F.

    2014-01-01

    The current article builds on "Living the Good (Work) Life: Implications of General Values for Work Values" (Carlstrom, 2011) by presenting ways to address work values in career advising. The following questions are addressed in the current article: When should students explore work values in career advising? What career development and…

  15. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

    Science.gov (United States)

    Kröger, Nicolaus; Holler, Ernst; Kobbe, Guido; Bornhäuser, Martin; Schwerdtfeger, Rainer; Baurmann, Herrad; Nagler, Arnon; Bethge, Wolfgang; Stelljes, Matthias; Uharek, Lutz; Wandt, Hannes; Burchert, Andreas; Corradini, Paolo; Schubert, Jörg; Kaufmann, Martin; Dreger, Peter; Wulf, Gerald G; Einsele, Hermann; Zabelina, Tatjana; Kvasnicka, Hans Michael; Thiele, Jürgen; Brand, Ronald; Zander, Axel R; Niederwieser, Dietger; de Witte, Theo M

    2009-12-17

    From 2002 to 2007, 103 patients with primary myelofibrosis or postessential thrombocythemia and polycythemia vera myelofibrosis and a median age of 55 years (range, 32-68 years) were included in a prospective multicenter phase 2 trial to determine efficacy of a busulfan (10 mg/kg)/fludarabine (180 mg/m(2))-based reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation from related (n = 33) or unrelated donors (n = 70). All but 2 patients (2%) showed leukocyte and platelet engraftment after a median of 18 and 22 days, respectively. Acute graft-versus-host disease grade 2 to 4 occurred in 27% and chronic graft-versus-host disease in 43% of the patients. Cumulative incidence of nonrelapse mortality at 1 year was 16% (95% confidence interval, 9%-23%) and significantly lower for patients with a completely matched donor (12% vs 38%; P = .003). The cumulative incidence of relapse at 3 years was 22% (95% confidence interval, 13%-31%) and was influenced by Lille risk profile (low, 14%; intermediate, 22%; and high, 34%; P = .02). The estimated 5-year event-free and overall survival was 51% and 67%, respectively. In a multivariate analysis, age older than 55 years (hazard ratio = 2.70; P = .02) and human leukocyte antigen-mismatched donor (hazard ratio = 3.04; P = .006) remained significant factors for survival. The study was registered at www.clinicaltrials.gov as #NCT 00599547.

  16. Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT.

    Science.gov (United States)

    Canaani, Jonathan; Beohou, Eric; Labopin, Myriam; Socié, Gerard; Huynh, Anne; Volin, Liisa; Cornelissen, Jan; Milpied, Noel; Gedde-Dahl, Tobias; Deconinck, Eric; Fegueux, Nathalie; Blaise, Didier; Mohty, Mohamad; Nagler, Arnon

    2017-04-01

    The French, American, and British (FAB) classification system for acute myeloid leukemia (AML) is extensively used and is incorporated into the AML, not otherwise specified (NOS) category in the 2016 WHO edition of myeloid neoplasm classification. While recent data proposes that FAB classification does not provide additional prognostic information for patients for whom NPM1 status is available, it is unknown whether FAB still retains a current prognostic role in predicting outcome of AML patients undergoing allogeneic stem cell transplantation. Using the European Society of Blood and Bone Marrow Transplantation registry we analyzed outcome of 1690 patients transplanted in CR1 to determine if FAB classification provides additional prognostic value. Multivariate analysis revealed that M6/M7 patients had decreased leukemia free survival (hazard ratio (HR) of 1.41, 95% confidence interval (CI), 1.01-1.99; P = .046) in addition to increased nonrelapse mortality (NRM) rates (HR, 1.79; 95% CI, 1.06-3.01; P = .028) compared with other FAB types. In the NPM1 wt AML, NOS cohort, FAB M6/M7 was also associated with increased NRM (HR, 2.17; 95% CI, 1.14-4.16; P = .019). Finally, in FLT3-ITD + patients, multivariate analyses revealed that specific FAB types were tightly associated with adverse outcome. In conclusion, FAB classification may predict outcome following transplantation in AML, NOS patients. © 2017 Wiley Periodicals, Inc.

  17. Work family conflict in its relations to perceived working situation and work engagement.

    Science.gov (United States)

    Mache, Stefanie; Bernburg, Monika; Groneberg, David A; Klapp, Burghard F; Danzer, Gerhard

    2016-02-15

    These days physicians' work is characterized by an increase in economic demands, pressure and challenges in establishing a balance between work and family life. The current study investigates the relationship between physicians' job demands and resources, perceived job stress, work-family conflict, work engagement and job satisfaction. 564 clinicians specialising in different medical fields participated in the cross-sectional study. Self-administered questionnaires, including the COPSOQ and the UWES- Scale were administered. Our results illustrated significant relationships between physicians' work engagement and their job satisfaction as well as between job stress and work family conflict. Moreover, perceived job stress moderated the effect of high job demands on work family conflict. In addition, significant gender differences have been found in perceived stress levels, work family conflict and work engagement. This study proves and verified associations between work engagement, work-family conflict, job demands and resources that may influence employees' satisfaction. Implications for both working physicians and hospital management are given.

  18. Blended working: for whom it may (not work.

    Directory of Open Access Journals (Sweden)

    Nico W Van Yperen

    Full Text Available Similarly to related developments such as blended learning and blended care, blended working is a pervasive and booming trend in modern societies. Blended working combines on-site and off-site working in an optimal way to improve workers' and organizations' outcomes. In this paper, we examine the degree to which workers feel that the two defining features of blended working (i.e., time-independent working and location-independent working enhance their own functioning in their jobs. Blended working, enabled through the continuing advance and improvement of high-tech ICT software, devices, and infrastructure, may be considered beneficial for workers' perceived effectiveness because it increases their job autonomy. However, because blended working may have downsides as well, it is important to know for whom blended working may (not work. As hypothesized, in a sample of 348 workers (51.7% women, representing a wide range of occupations and organizations, we found that the perceived personal effectiveness of blended working was contingent upon workers' psychological need strength. Specifically, the perceived effectiveness of both time-independent working and location-independent working was positively related to individuals' need for autonomy at work, and negatively related to their need for relatedness and need for structure at work.

  19. Blended working: for whom it may (not) work.

    Science.gov (United States)

    Van Yperen, Nico W; Rietzschel, Eric F; De Jonge, Kiki M M

    2014-01-01

    Similarly to related developments such as blended learning and blended care, blended working is a pervasive and booming trend in modern societies. Blended working combines on-site and off-site working in an optimal way to improve workers' and organizations' outcomes. In this paper, we examine the degree to which workers feel that the two defining features of blended working (i.e., time-independent working and location-independent working) enhance their own functioning in their jobs. Blended working, enabled through the continuing advance and improvement of high-tech ICT software, devices, and infrastructure, may be considered beneficial for workers' perceived effectiveness because it increases their job autonomy. However, because blended working may have downsides as well, it is important to know for whom blended working may (not) work. As hypothesized, in a sample of 348 workers (51.7% women), representing a wide range of occupations and organizations, we found that the perceived personal effectiveness of blended working was contingent upon workers' psychological need strength. Specifically, the perceived effectiveness of both time-independent working and location-independent working was positively related to individuals' need for autonomy at work, and negatively related to their need for relatedness and need for structure at work.

  20. Working Together in Class

    Directory of Open Access Journals (Sweden)

    Pateşan Marioara

    2017-12-01

    Full Text Available The scores obtained by the military students are very important as a lot of opportunities depend on them: the choice of the branch, selection for different in and off-campus activities, the appointment to the workplace and so on. A qualifier, regardless of its form of effective expression, can make a difference in a given context of issuing a value judgment, in relation to the student's performance assessment. In our research we tried to find out what motives students, what determines them to get actively involved in the tasks they are given and the ways we can improve their participation in classes and assignments. In order to have an educated generation we need to have not only well prepared teachers but ones that are open-minded, flexible and in pace with the methodological novelties that can improve the teaching learning process in class. Along the years we have noticed that in classes where students constituted a cohesive group with an increasing degree of interaction between members, the results were better than in a group that did not appreciate team-work. In this article we want to highlight the fact that a teacher can bring to class the appropriate methods and procedures can contribute decisively to the strengthening of the group cohesion and high scores.

  1. Maritime Work and Communication

    Directory of Open Access Journals (Sweden)

    Peter Andersen

    2001-05-01

    Full Text Available This paper presents findings from the project "Elastic Systems" under the Danish Center for Human Machine Interaction. The project aims at developing methods for analyzing dynamic maritime work processes and for designing flexible instrument interfaces that will support changing work environments. Here I only address the former issue, the design issues being published elsewhere, e.g. in Andersen(1999 and Andersen & May (2001. More data can be found in Andersen(2000. The purpose of the present paper is twofold: (1 to present characteristics of maritime work and communication, and (2 to suggest a conceptual framework that covers communicative as well as non-communicative acts. The latter purpose is motivated in two ways. Theoretical motivation: we know that language is self-referential, so that it can speak of non-linguistic entities like ships and waves as well as its own properties, such as the correct wording or style. The easiest way to accomplish this is for language to treat both domains in a similar way. The other motivation is more practical: it is a fact that communication and physical actions are interwoven in maritime work, and a theory that builds on a sharp distinction between these two kinds of behaviors will miss this basic characteristic. The data is from a voyage aboard Sally Maersk from Algeciras to Goteborg and back to Rotterdam. We recorded 60 hours of high quality video, and the paper builds upon a 16 hours trip from Felixstowe to Rotterdam, supplemented by data from simulated voyages in the simulator at the Danish Maritime Institute. The conceptual framework is based on Lind 1994 and Lind 2000 and distinguishes between the following types of action types: (1 Prevent(suppress, avoid: if I hadn't done it, then an undesirable state would have developed. Prevent drifting by using auxiliary rudder. (2 Maintain: if I hadn't done it, then a desirable state would have disappeared. Maintain course. (3 Help: a positive state would have

  2. Working the Dark Side

    DEFF Research Database (Denmark)

    Bjering, Jens Christian Borrebye

    A few days after the terror attacks of 9/11, then Vice President Dick Cheney appeared on television with a call for “working the dark side.” While still unclear what this expression entailed at the time, Cheney's comment appears in retrospect to almost have been prophetic for the years to come...... – years where parts of the U.S. Army and intelligence community set up a rampant torture regime all across the world. Yet, the connection between a so-called “dark side,” “working” this “dark side,” and the torture that followed is not a given, but, instead, a consequence of a set of very specific legal......, political, and personal choices in the early years after 9/11. This dissertation is an investigation into how the notion of a “dark side” took form, and of how and why the specific make-up of this“dark side” ended up creating a torture regime which already today seems almost unreal. The dissertation's first...

  3. Ansel Adams: early works

    Science.gov (United States)

    Throckmorton, Jodi

    2010-02-01

    Ansel Adams (1902-1984), photographer, musician, naturalist, explorer, critic, and teacher, was a giant in the field of landscape photography. In his images of the unspoiled Western landscape, he strove to capture the sublime: the transcendentalist concept that nature can generate the experience of awe for the viewer. Many viewers are familiar with the heroic, high-contrast prints on high-gloss paper that Adams made to order beginning in the 1970s; much less well known are the intimate prints that the artist crafted earlier in his career. This exhibition focuses on these masterful small prints from the 1920s into the 1950s. During this time period, Adams's printing style changed dramatically. The painterly, soft-focus, warm-toned style of the Parmelian Prints of the High Sierras from the 1920s evolved into the sharp-focus style of the f/64 school of photography that Adams co-founded in the 1930s with Edward Weston and Imogen Cunningham. After World War II, Adams opted for a cooler, higher-contrast look for his prints. Throughout the various styles in which he chose to work, Adams explored the power of nature and succeeded in establishing landscape photography as a legitimate form of modern art.

  4. Proposal Improvements That Work

    Science.gov (United States)

    Dunn, F.

    1998-01-01

    Rocketdyne Propulsion and Power, an operating location of Boeing in Canoga Park, California is under contract with NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama for design, development, production, and mission support of Space Shuttle Main Engines (SSMEs). The contract was restructured in 1996 to emphasize a mission contracting environment under which Rocketdyne supports the Space Transportation System launch manifest of seven flights a year without the need for a detailed list of contract deliverables such as nozzles, turbopumps, and combustion devices. This contract structure is in line with the overall Space Shuttle program goals established by the NASA to fly safely, meet the flight manifest, and reduce cost. Rocketdyne's Contracts, Pricing, and Estimating team has worked for the past several years with representatives from MSFC, the local Defense Contract Management Command, and the DCAA to improve the quality of cost proposals to MSFC for contract changes on the SSME. The contract changes on the program result primarily from engineering change proposals for product enhancements to improve safety, maintainability, or operability in the space environment. This continuous improvement team effort has been successful in improving proposal quality, reducing cycle time, and reducing cost. Some of the principal lessons learned are highlighted here to show how proposal improvements can be implemented to enhance customer satisfaction and ensure cost proposals can be evaluated easily by external customers.

  5. Social strategies that work.

    Science.gov (United States)

    Piskorski, Mikołaj Jan

    2011-11-01

    Although most companies have collected lots of friends and followers on social platforms such as Facebook, few have succeeded in generating profits there. That's because they merely port their digital strategies into social environments by broadcasting their commercial messages or seeking customer feedback. To succeed on social platforms, says Harvard Business School's Piskorski, businesses need to devise social strategies that are consistent with users' expectations and behavior in these venues--namely, people want to connect with other people, not with companies. The author defines successful social strategies as those that reduce costs or increase customers' willingness to pay by helping people establish or strengthen relationships through doing free work on a company's behalf. Citing successes at Zynga, eBay, American Express, and Yelp, Piskorski shows that social strategies can generate profits by helping people connect in exchange for tasks that benefit the company such as customer acquisition, marketing, and content creation. He lays out a systematic way to build a social strategy and shows how a major credit card company he advised used the method to roll out its own strategy.

  6. [Work, cardiopathy, and sports].

    Science.gov (United States)

    Assanelli, D; Cottarelli, C; Salvadori, G; Rubino, F; Fernando, F; Biffi, A

    2004-01-01

    Heart disease is the main cause of early disability and premature death in Europe. Regular physical activity may prevent heart disease, diabetes, ictus, and obesity. Nevertheless, a certain resistance to a dynamic lifestyle, lack of free time, lack of motivation and other factors are frequently encountered. To stress the importance of physical activity in the prevention of cardiovascular disease. A literature review of the main risk factors for cardiovascular disease was carried out. It has been shown that physical exercise is beneficial to the cardiovascular apparatus and to the bones and joints, by improving some metabolic parameters. Recent studies have shown that a personalized, moderate physical activity should be suggested for primary and secondary prevention, in particular for subjects with coronary artery disease and left ventricular dysfunction. An increase in sports activity and physical exercise at work and at school is recommended so as to improve quality of life and promote home rehabilitation. Some promising experience has already been made among workers and their families with excellent results, as shown by a follow-up period of three years.

  7. Cleaning of work clothing

    CERN Multimedia

    2007-01-01

    As of March 2007, the laundry service (TS/FM) will introduce a new procedure for the collection of work clothing and its redistribution when returned to CERN from the laundry. Clothes will no longer be collected from and distributed to the usual points, but will have to be deposited and exchanged at a pre-defined location and at specific times, as follows: For Meyrin site: in Bldg. 2/ R-402 Each second Thursday between 8-00 and 9-30. Starting on Thursday, March 22, 2007. For Prévessin site and SM18: in Bldg. 933/ R-007. Each second Thursday between 10-00 and 11-30. Starting on Thursday, March 22, 2007. Notices explaining the procedure to be followed will be posted at the collection points used until now. No change in present practice is foreseen, however, for LHC Points 2 and 5. If you require any further information please call the laundry service on 16 2056 or 16 0053.

  8. Cleaning of work clothing

    CERN Multimedia

    2007-01-01

    As of March 2007, the laundry service (TS/FM) will introduce a new procedure for the collection of work clothing and its redistribution when returned to CERN from the laundry. Clothes will no longer be collected from and distributed to the usual points, but will have to be deposited and exchanged at a pre-defined location and specific time, as specified below: For Meyrin site: Bldg. 2/ R-402 Every second Thursday between 8-00 and 9-30. Starting on Thursday, March 22, 2007. For Prévessin site and SM18: Bldg. 933/ R-007. Every second Thursday between 10-00 and 11-30. Starting on Thursday, March 22, 2007. Notices explaining the procedure to be followed will be posted at the collection points used until now. No change in present practice is foreseen, however, for LHC Points 2 and 5. If you require any further information please call the laundry service on 16 2056 or 16 0053.

  9. Cleaning of work clothing

    CERN Multimedia

    2007-01-01

    As of March 2007, the laundry service (TS/FM) will introduce a new procedure for the collection of work clothing and its redistribution when returned to CERN from the laundry. Clothes will no longer be collected from and distributed to the usual points, but will have to be deposited and exchanged at a pre-defined location and specific time, as specified below: For Meyrin site: Bldg. 2/ R-402 Every second Thursday between 8.00 a.m. and 9.30 a.m. Starting on Thursday, March 22, 2007. For Prévessin site and SM18: Bldg. 933/ R-007. Every second Thursday between 10.00 a.m. and 11.30 a.m. Starting on Thursday, March 22, 2007. Notices explaining the procedure to be followed will be posted at the collection points used until now. No change in present practice is foreseen, however, for LHC Points 2 and 5. If you require any further information please call the laundry service on 16 2056 or 16 0053.

  10. Pregnant and other works

    Directory of Open Access Journals (Sweden)

    Elinor Carucci

    2013-01-01

    Full Text Available I have been photographing my children, Eden and Emmanuelle since I got pregnant in 2003. I photograph as a mother, from a mother's point of view, showing the different aspects of motherhood as I see them; the beautiful and the ugly, the magic and the frustration, the extremes that live side by side when you are a mother. I try to photograph them all. Crying, sadness, anxiety, mourning the body I will never have again, the woman I will never be again. The strong physical connection to the children, erotic at times, something I found out many mothers experience but do not talk about much. With my images I try to sing a love song to my children, they are my inspiration. Their love, sadness, joy and neediness are for me the most meaningful moments of my life, the moments I want to photograph and preserve. Those images are taken from my life, they are very personal, they are about being a mother, being a child, the intensity of raising a child. This work is about the essence of being human.

  11. How Google works

    CERN Document Server

    Schmidt, Eric; Eagle, Alan

    2014-01-01

    Google Executive Chairman and ex-CEO Eric Schmidt and former SVP of Products Jonathan Rosenberg came to Google over a decade ago as proven technology executives. At the time, the company was already well-known for doing things differently, reflecting the visionary--and frequently contrarian--principles of founders Larry Page and Sergey Brin. If Eric and Jonathan were going to succeed, they realized they would have to relearn everything they thought they knew about management and business. Today, Google is a global icon that regularly pushes the boundaries of innovation in a variety of fields. HOW GOOGLE WORKS is an entertaining, page-turning primer containing lessons that Eric and Jonathan learned as they helped build the company. The authors explain how technology has shifted the balance of power from companies to consumers, and that the only way to succeed in this ever-changing landscape is to create superior products and attract a new breed of multifaceted employees whom Eric and Jonathan dub "smart creat...

  12. Putting super-resolution fluorescence microscopy to work

    OpenAIRE

    Lippincott-Schwartz, J; Manley, Suliana

    2009-01-01

    Super-resolution microscopy is poised to revolutionize our understanding of the workings of the cell. But the technology still has some limitations, and these must be taken into consideration if widespread application is to yield biological insight.

  13. Distracted driving due to visual working memory load.

    Science.gov (United States)

    2014-07-01

    In an attempt to understand the : specific mechanism by which distractions (such as cell : - : phone use) can interfere with : driving, this work tested the idea that driving performance depends on available space within visual short : - : term memor...

  14. Association of Macroeconomic Factors With Nonrelapse Mortality After Allogeneic Hematopoietic Cell Transplantation for Adults With Acute Lymphoblastic Leukemia: An Analysis From the Acute Leukemia Working Party of the EBMT.

    Science.gov (United States)

    Giebel, Sebastian; Labopin, Myriam; Ibatici, Adalberto; Browne, Paul; Czerw, Tomasz; Socie, Gerard; Unal, Ali; Kyrcz-Krzemien, Slawomira; Bacigalupo, Andrea; Goker, Hakan; Potter, Mike; Furness, Caroline L; McQuaker, Grant; Beelen, Dietrich; Milpied, Noel; Campos, Antonio; Craddock, Charles; Nagler, Arnon; Mohty, Mohamad

    2016-03-01

    From a global perspective, the rates of allogeneic hematopoietic cell transplantation (alloHCT) are closely related to the economic status of a country. However, a potential association with outcome has not yet been documented. The goal of this study was to evaluate effects of health care expenditure (HCE), Human Development Index (HDI), team density, and center experience on nonrelapse mortality (NRM) after HLA-matched sibling alloHCT for adults with acute lymphoblastic leukemia (ALL). A total of 983 patients treated with myeloablative alloHCT between 2004 and 2008 in 24 European countries were included. In a univariate analysis, the probability of day 100 NRM was increased for countries with lower current HCE (8% vs. 3%; p = .06), countries with lower HDI (8% vs. 3%; p = .02), and centers with less experience (8% vs. 5%; p = .04). In addition, the overall NRM was increased for countries with lower current HCE (21% vs. 17%; p = .09) and HDI (21% vs. 16%; p = .03) and for centers with lower activity (21% vs. 16%; p = .07). In a multivariate analysis, the strongest predictive model for day 100 NRM included current HCE greater than the median (hazard ratio [HR], 0.39; p = .002). The overall NRM was mostly predicted by HDI greater than the median (HR, 0.65; p = .01). Both lower current HCE and HDI were associated with decreased probability of overall survival. Both macroeconomic factors and the socioeconomic status of a country strongly influence NRM after alloHCT for adults with ALL. Our findings should be considered when clinical studies in the field of alloHCT are interpreted. ©AlphaMed Press.

  15. Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP of the European Society for Blood and Marrow Transplantation (EBMT

    Directory of Open Access Journals (Sweden)

    Xavier Poiré

    2017-01-01

    Full Text Available Abstract Background Acute myeloid leukaemia (AML with 17p abnormalities (abn(17p carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT appears as the only potential curative option. Methods To address outcomes after allo-SCT in patients with abn(17p, we retrospectively analysed de novo or secondary AML undergoing SCT between 2000 and 2013 from the EBMT registry. Results One hundred thirty-nine patients with confirmed abn(17p have been selected. At the time of transplant, one hundred twenty-five were in first remission (CR1. Median age was 54 years old. Abn(17p was associated with a monosomal karyotype in 83% of patients, complex karyotype in 91%, monosomy 5 or 5q deletion (-5/5q- in 55%, monosomy 7 (-7 in 39% and both -5/5q and -7 in 27%. Seventy-three patients (59% had a reduced-intensity conditioning regimen. The 2-year overall survival (OS and leukaemia-free survival (LFS were 28 and 24%, respectively. The 2-year non-relapse mortality (NRM was 15%, and 2-year relapse incidence (RI was 61%. The cumulative incidence of grade II to IV acute graft-versus-host disease (GvHD was 24% and that of chronic GvHD was 21%. In multivariate analysis, the presence of a -5/5q- in addition to abn(17p was significantly and independently associated with worse OS, LFS and higher RI. Age and donor types did not correlate with outcome. Conditioning intensity was not statistically associated with OS, LFS and NRM when adjusted for patients’ age. Conclusions In contrast to the dismal prognosis reported for AML patients harbouring abn(17p undergoing conventional chemotherapy, allogeneic SCT provides responses in about 25% of those patients transplanted in CR1.

  16. Reincentivizing – a new theory of work and work absence

    Directory of Open Access Journals (Sweden)

    Thulesius Hans O

    2007-07-01

    Full Text Available Abstract Background Work capacity correlates weakly to disease concepts, which in turn are insufficient to explain sick leave behavior. With data mainly from Sweden, a welfare state with high sickness absence rates, our aim was to develop an explanatory theory of how to understand and deal with work absence and sick leave. Methods We used classic grounded theory for analyzing data from >130 interviews with people working or on sick leave, physicians, social security officers, and literature. Several hundreds of typed and handwritten memos were the basis for writing up the theory. Results In this paper we present a theory of work incentives and how to deal with work absence. We suggest that work disability can be seen as hurt work drivers or people caught in mode traps. Work drivers are specified as work capacities + work incentives, monetary and non-monetary. Also, people can get trapped in certain modes of behavior through changed capacities or incentives, or by inertia. Different modes have different drivers and these can trap the individual from reincentivizing, ie from going back to work or go on working. Hurt drivers and mode traps are recognized by driver assessments done on several different levels. Mode driver calculations are done by the worker. Then follows employer, physician, and social insurance officer assessments. Also, driver assessments are done on the macro level by legislators and other stakeholders. Reincentivizing is done by different repair strategies for hurt work drivers such as body repair, self repair, work-place repair, rehumanizing, controlling sick leave insurance, and strengthening monetary work incentives. Combinations of these driver repair strategies also do release people from mode traps. Conclusion Reincentivizing is about recognizing hurt work drivers and mode traps followed by repairing and releasing the same drivers and traps. Reincentivizing aims at explaining what is going on when work absence is dealt

  17. Clinical utility of18F-FDG positron emission tomography/computed tomography scan vs.99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis.

    Science.gov (United States)

    Lauridsen, Trine K; Iversen, Kasper K; Ihlemann, Nikolaj; Hasbak, Philip; Loft, Annika; Berthelsen, Anne K; Dahl, Anders; Dejanovic, Danijela; Albrecht-Beste, Elisabeth; Mortensen, Jann; Kjær, Andreas; Bundgaard, Henning; Bruun, Niels Eske

    2017-05-01

    The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether 18 FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.

  18. A Relational Theory of Working

    Science.gov (United States)

    Blustein, David L.

    2011-01-01

    Building on diverse influences from critical perspectives in vocational psychology and the relational movement in contemporary psychological discourse, this article introduces the relational theory of working. Attending to the full array of people who work and who want to work, the relational theory conceptualizes working as an inherently…

  19. Social Work Education in Denmark

    DEFF Research Database (Denmark)

    Skytte, Marianne

    2005-01-01

    The development of the social work education and the education for social educators in Denmark. The undergraduate programs and the possibilities for further study within social work in Denmark.......The development of the social work education and the education for social educators in Denmark. The undergraduate programs and the possibilities for further study within social work in Denmark....

  20. Desert Pathfinder at Work

    Science.gov (United States)

    2005-09-01

    The Atacama Pathfinder Experiment (APEX) project celebrates the inauguration of its outstanding 12-m telescope, located on the 5100m high Chajnantor plateau in the Atacama Desert (Chile). The APEX telescope, designed to work at sub-millimetre wavelengths, in the 0.2 to 1.5 mm range, passed successfully its Science Verification phase in July, and since then is performing regular science observations. This new front-line facility provides access to the "Cold Universe" with unprecedented sensitivity and image quality. After months of careful efforts to set up the telescope to work at the best possible technical level, those involved in the project are looking with satisfaction at the fruit of their labour: APEX is not only fully operational, it has already provided important scientific results. "The superb sensitivity of our detectors together with the excellence of the site allow fantastic observations that would not be possible with any other telescope in the world," said Karl Menten, Director of the group for Millimeter and Sub-Millimeter Astronomy at the Max-Planck-Institute for Radio Astronomy (MPIfR) and Principal Investigator of the APEX project. ESO PR Photo 30/05 ESO PR Photo 30/05 Sub-Millimetre Image of a Stellar Cradle [Preview - JPEG: 400 x 627 pix - 200k] [Normal - JPEG: 800 x 1254 pix - 503k] [Full Res - JPEG: 1539 x 2413 pix - 1.3M] Caption: ESO PR Photo 30/05 is an image of the giant molecular cloud G327 taken with APEX. More than 5000 spectra were taken in the J=3-2 line of the carbon monoxide molecule (CO), one of the best tracers of molecular clouds, in which star formation takes place. The bright peak in the north of the cloud is an evolved star forming region, where the gas is heated by a cluster of new stars. The most interesting region in the image is totally inconspicuous in CO: the G327 hot core, as seen in methanol contours. It is a truly exceptional source, and is one of the richest sources of emission from complex organic molecules in the

  1. [Working under supervision].

    Science.gov (United States)

    Pafko, P; Mach, J

    2013-08-01

    A graduate from a medical school who has obtained only, so called, adequate competence/ expertise must work under a supervision of a doctor who has the relevant specialised competence certification in order for the graduate to obtain this specialised competence as well. It is recommended to determine in writing which activities the doctor in training can perform alone during that time, which need to be supervised by the responsible doctor, and which treatment he is not yet prepared to perform at all. The head doctor or the head of the clinic is responsible for ensuring a full-time supervision of the doctor trainee by a certified specialist. If the trainee has obtained a certificate of completion of the basic level training of the relevant specialised module then he can serve during emergency hours under the condition that the presence of a specialised doctor is ensured to be within 20 minutes if needed. The head doctor, the head of the clinic or the specialised medical supervisor have no universal responsibility for any possible misconduct of the trainee. Everyone is responsible for his own conduct. The responsibility of the head doctor and the head of the clinic may be relevant if they did not fulfil the duties of being a supervising doctor. The responsibility may also be relevant if the supervising was neglected. Responsibility for the trainee may arise if he did not respect the orders from the supervisor or if the misconduct was such that it would be unacceptable even for a doctor without the relevant professional competence. If it is the case that the misconduct happens despite the supervising being absolutely correct, and under the conditions that the misconduct was unavoidable, the supervising attested professional doctor cannot be responsible for the consequences. Manual misconduct during a surgery is usually regarded to be accepted risk not violation of the rules of medical science.

  2. FOR MUSEUM WORK

    Directory of Open Access Journals (Sweden)

    Margherita Sani

    2017-05-01

    Full Text Available The role of museums in society has expanded significantly in the last decades: from temples of knowledge to forums for debate and discussion, from repositories of objects to people-centred institutions with social responsibilities and functions. This shift reflects an ongoing trend to democratise museums and make them more accessible to wider audiences and responsive to the public’s changing needs, in particular the interests of local communities, whose composition has changed in recent years to include migrants and people of different ethnic backgrounds. With annual migration flows to the EU as a whole projected to increase from about 1 043 000 people in 2010 to 1 332 500 by 2020, the question of how cultural institutions can contribute to effective integration and dialogue has become more relevant than ever. Funders and society at large expect museums to play their part in facilitating the integration and peaceful coexistence of newcomers, with financial resources being made available, also at the EU level, to support them in this effort. Many questions can be raised as to whether it is right and appropriate to charge museums with these responsibilities and whether this would push the boundaries of their work too far and give the social function an exceedingly prominent role over the traditional conservation and educational tasks museums already fulfil. But this discussion seems to be already obsolete in the light of the growing body of evidence on good practices available at the European level. This essay aims to illustrate some of them, as well as to discuss some underpinning theoretical issues and methodological approaches.

  3. How venture capital works.

    Science.gov (United States)

    Zider, B

    1998-01-01

    The popular mythology surrounding the U.S. venture-capital industry derives from a previous era. Venture capitalists who nurtured the computer industry in its infancy were legendary both for their risk taking and for their hands-on operating experience. But today things are different, and separating the myths from the realities is crucial to understanding this important piece of the U.S. economy. Today's venture capitalists are more like conservative bankers than the risk takers of days past. They have carved out a specialized niche in the capital markets, filling a void that other institutions cannot serve. They are the linch-pins in an efficient system for meeting the needs of institutional investors looking for high returns, of entrepreneurs seeking funding, and of investment bankers looking for companies to sell. Venture capitalists must earn a consistently superior return on investments in inherently risky businesses. The myth is that they do so by investing in good ideas and good plans. In reality, they invest in good industries--that is, industries that are more competitively forgiving than the market as a whole. And they structure their deals in a way that minimizes their risk and maximizes their returns. Although many entrepreneurs expect venture capitalists to provide them with sage guidance as well as capital, that expectation is unrealistic. Given a typical portfolio of ten companies and a 2,000-hour work year, a venture capital partner spends on average less than two hours per week on any given company. In addition to analyzing the current venture-capital system, the author offers practical advice to entrepreneurs thinking about venture funding.

  4. Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

    Directory of Open Access Journals (Sweden)

    Eolia Brissot

    2017-06-01

    Full Text Available Abstract Background Primary refractory acute myeloid leukemia (PRF-AML is associated with a dismal prognosis. Allogeneic stem cell transplantation (HSCT in active disease is an alternative therapeutic strategy. The increased availability of unrelated donors together with the significant reduction in transplant-related mortality in recent years have opened the possibility for transplantation to a larger number of patients with PRF-AML. Moreover, transplant from unrelated donors may be associated with stronger graft-mediated anti-leukemic effect in comparison to transplantations from HLA-matched sibling donor, which may be of importance in the setting of PRF-AML. Methods The current study aimed to address the issue of HSCT for PRF-AML and to compare the outcomes of HSCT from matched sibling donors (n = 660 versus unrelated donors (n = 381, for patients with PRF-AML between 2000 and 2013. The Kaplan-Meier estimator, the cumulative incidence function, and Cox proportional hazards regression models were used where appropriate. Results HSCT provide patients with PRF-AML a 2-year leukemia-free survival and overall survival of about 25 and 30%, respectively. In multivariate analysis, two predictive factors, cytogenetics and time from diagnosis to transplant, were associated with lower leukemia-free survival, whereas Karnofsky performance status at transplant ≥90% was associated with better leukemia-free survival (LFS. Concerning relapse incidence, cytogenetics and time from diagnosis to transplant were associated with increased relapse. Reduced intensity conditioning regimen was the only factor associated with lower non-relapse mortality. Conclusions HSCT was able to rescue about one quarter of the patients with PRF-AML. The donor type did not have any impact on PRF patients’ outcomes. In contrast, time to transplant was a major prognostic factor for LFS. For patients with PRF-AML who do not have a matched sibling donor, HSCT from an

  5. Work engagement: drivers and effects

    OpenAIRE

    Bakhuys Roozeboom, M.M.C.; Schelvis, R.

    2014-01-01

    The concept of work engagement fits into the tradition of positive psychology, a recent paradigm shift in psychology which focuses on mental health rather than mental illness. This article gives an introduction to the concept of work engagement. Different definitions and viewpoints of the work engagement concept are discussed. This article will discuss the drivers of work engagement, as well as the associated effects that work engagement has on the health and wellbeing of workers and organisa...

  6. Supporting clinician educators to achieve “work-work balance”

    Directory of Open Access Journals (Sweden)

    Jerry M Maniate

    2016-10-01

    Full Text Available Clinician Educators (CE have numerous responsibilities in different professional domains, including clinical, education, research, and administration. Many CEs face tensions trying to manage these often competing professional responsibilities and achieve “work-work balance.” Rich discussions of techniques for work-work balance amongst CEs at a medical education conference inspired the authors to gather, analyze, and summarize these techniques to share with others. In this paper we present the CE’s “Four Ps”; these are practice points that support both the aspiring and established CE to help improve their performance and productivity as CEs, and allow them to approach work-work balance.

  7. Restructuring Teachers' Work

    Directory of Open Access Journals (Sweden)

    Lisa Kirtman

    2002-05-01

    Full Text Available Despite repeated attempts to reform schools, teachers' work has remained surprisingly stable. The purpose of this study was to investigate implementation of a state-funded restructuring initiative that intended broad changes in teachers' professional roles. Sponsors of the founding legislation reasoned that changes in teachers' roles would contribute to higher student achievement. This study examined the question of whether and how this program of comprehensive whole-school change promoted changes in teachers' roles in school governance, collegial relations, and the classroom. Further, the study traced the relationship of these changes to one another, and weighed the likelihood that they had the capacity to affect core educational practices. Theoretically, this study is situated in the available literature on teachers' collegial relations; participation in shared decision making; and classroom roles, relationships and practice. Three elementary schools served as the sites for intensive qualitative data collection completed over a two-year period. The schools differed in geographic location (two urban, one rural, but all enrolled a racially, ethnically and linguistically diverse population of students, and more than half of the students in each school qualified for free or reduced price lunch. The study resulted in multiple types and sources of data on teachers' professional roles, including: observations in classrooms, collegial interactions, and governance situations; interviews with teachers (including teacher leaders, parents, administrators, and students; and documents pertaining to the restructuring plans and process. Findings show that changes in the three areas were achieved unevenly in the three schools. All three schools introduced changes in classroom practice and roles, ranging from the adoption of multi-age classrooms to more modest innovations in curriculum or instruction. In only one case were changes in professional roles outside

  8. Seventh Edition Fuel Cell Handbook

    Energy Technology Data Exchange (ETDEWEB)

    NETL

    2004-11-01

    Provides an overview of fuel cell technology and research projects. Discusses the basic workings of fuel cells and their system components, main fuel cell types, their characteristics, and their development status, as well as a discussion of potential fuel cell applications.

  9. Work-Family Facilitation and Conflict, Working Fathers and Mothers, Work-Family Stressors and Support

    Science.gov (United States)

    Hill, E. Jeffrey

    2005-01-01

    Work-family research frequently focuses on the conflict experienced by working mothers. Using data from the National Study of the Changing Workforce (N = 1,314), this study also examined work-family facilitation and working fathers. Ecological systems, family stress, family resilience, and sex role theories were used to organize the data and…

  10. The effects of work alienation on organisational commitment, work effort and work-to-family enrichment.

    Science.gov (United States)

    Tummers, Lars G; Den Dulk, Laura

    2013-09-01

    The aim of this study was to analyse the effects of work alienation on organisational commitment, work effort and work-to-family enrichment. There is substantial research on the effects of work alienation on passive job performance, such as organisational commitment. However, studies analysing work alienation on active performance, such as work effort, and outside work, such as work-to-family enrichment, are scarce. Two dimensions of work alienation are considered: powerlessness and meaninglessness. Hypotheses are tested using surveys collected among a national sample of midwives in the Netherlands (respondents: 790, response rate 61%). the findings indicate that work alienation (powerlessness and meaninglessness) influence organisational commitment, work effort and--to a lesser extent--work-to-family enrichment. High work meaninglessness, in particular, has negative effects on these outcomes. When people feel that they have no influence in their work (hence, when they feel 'powerless') and especially when the feel that their work is not worthwhile (when they feel 'meaningless') this has substantial negative effects. Managers should increase the meaningfulness that people attach to their work, thereby maintaining a high-quality workforce. Possible strategies include: (1) improving person-job fit, (2) developing high-quality relationships, (3) better communicating the results people help to deliver. © 2013 John Wiley & Sons Ltd.

  11. "Work Gave Me a Lot of Confianza": Chicanas' Work Commitment and Work Identity.

    Science.gov (United States)

    Pesquera, Beatriz M.

    1991-01-01

    Extensive interviews with 24 married Chicana workers with children examined socialization to work in family of origin, early employment, educational attainment, and familial and employment factors influencing levels of work commitment and work identity. Professional, clerical, and blue-collar workers all had strong work commitment but differed in…

  12. The effects of work alienation on organizational commitment, work effort and work-to-family enrichment

    NARCIS (Netherlands)

    L.G. Tummers (Lars); L. den Dulk (Laura)

    2013-01-01

    textabstractAim: The aim of this study was to analyze the effects of work alienation on organizational commitment, work effort and work-to-family enrichment. Background: There is substantial research on the effects of work alienation on passive job performance, such as organizational commitment.

  13. Decent Work: A Psychological Perspective

    Directory of Open Access Journals (Sweden)

    David eBlustein

    2016-03-01

    Full Text Available This contribution, which serves as the lead article for the Research Section entitled From Meaning of Working to Meaningful Lives: The Challenges of Expanding Decent Work, explores current challenges in the development and operationalization of decent work. Based on an initiative from the International Labor Organization (ILO; 1999, decent work represents an aspirational statement about the quality of work that should be available to all people who seek to work around the globe. Within recent years, several critiques have been raised about decent work from various disciplines, highlighting concerns about a retreat from the social justice ethos that had initially defined the concept. In addition, other scholars have observed that decent work has not included a focus on the role of meaning and purpose at work. To address these concerns, we propose that a psychological perspective can help to revitalize the decent work agenda by infusing a more specific focus on individual experiences and by reconnecting decent work to its social justice origins. As an illustration of the advantages of a psychological perspective, we explore the rise of precarious work and also connect the decent work agenda to the Psychology-of-Working Framework and Theory (Blustein, 2006; Duffy, Blustein, Diemer, and Autin, in press.

  14. Decent Work: A Psychological Perspective.

    Science.gov (United States)

    Blustein, David L; Olle, Chad; Connors-Kellgren, Alice; Diamonti, A J

    2016-01-01

    This contribution, which serves as the lead article for the Research Topic entitled "From Meaning of Working to Meaningful Lives: The Challenges of Expanding Decent Work," explores current challenges in the development and operationalization of decent work. Based on an initiative from the International Labor Organization [ILO] (1999) decent work represents an aspirational statement about the quality of work that should be available to all people who seek to work around the globe. Within recent years, several critiques have been raised about decent work from various disciplines, highlighting concerns about a retreat from the social justice ethos that had initially defined the concept. In addition, other scholars have observed that decent work has not included a focus on the role of meaning and purpose at work. To address these concerns, we propose that a psychological perspective can help to revitalize the decent work agenda by infusing a more specific focus on individual experiences and by reconnecting decent work to its social justice origins. As an illustration of the advantages of a psychological perspective, we explore the rise of precarious work and also connect the decent work agenda to the Psychology-of-Working Framework and Theory (Blustein, 2006; Duffy et al., 2016).

  15. Work-Life Balance and Work Satisfaction in Workplace

    OpenAIRE

    Soo, Chin Hock

    2014-01-01

    This study aims to investigate whether the workplace environment in an ICT organizations are conducive for the employees to use work-life balance and secondary investigation will involving whether the ability to have work-life balance will increase the happiness and this job satisfaction and leads to higher productivity. A questionnaire which consisted of all the work-life balance activities in the ICT organization were sent out and a total of 94 respondents whom worked in ICT organizations h...

  16. Impact of working hours on work-life balance

    OpenAIRE

    Holly, Sarah; Mohnen, Alwine

    2012-01-01

    To examine the influence of working hours on employees' satisfaction, this article uses a large, representative set of panel data from German households (GSOEP). The results show that high working hours and overtime in general do not lead to decreased satisfaction. Rather, increasing working hours and overtime have positive effects on life and job satisfaction, whereas the desire to reduce working hours has a negative impact on satisfaction. In 2009, nearly 60% of employees wanted to reduce t...

  17. Poor working conditions and work stress among Canadian sex workers.

    Science.gov (United States)

    Duff, P; Sou, J; Chapman, J; Dobrer, S; Braschel, M; Goldenberg, S; Shannon, K

    2017-10-01

    While sex work is often considered the world's oldest profession, there remains a dearth of research on work stress among sex workers (SWs) in occupational health epidemiological literature. A better understanding of the drivers of work stress among SWs is needed to inform sex work policy, workplace models and standards. To examine the factors that influence work stress among SWs in Metro Vancouver. Analyses drew from a longitudinal cohort of SWs, known as An Evaluation of Sex Workers' Health Access (AESHA) (2010-14). A modified standardized 'work stress' scale, multivariable linear regression with generalized estimating equations was used to longitudinally examine the factors associated with work stress. In multivariable analysis, poor working conditions were associated with increased work stress and included workplace physical/sexual violence (β = 0.18; 95% confidence interval (CI) 0.06, 0.29), displacement due to police (β = 0.26; 95% CI 0.14, 0.38), working in public spaces (β = 0.73; 95% CI 0.61, 0.84). Older (β = -0.02; 95% CI -0.03, -0.01) and Indigenous SWs experienced lower work stress (β = -0.25; 95% CI -0.43, -0.08), whereas non-injection (β = 0.32; 95% CI 0.14, 0.49) and injection drug users (β = 0.17; 95% CI 0.03, 0.31) had higher work stress. Vancouver-based SWs' work stress was largely shaped by poor work conditions, such as violence, policing, lack of safe workspaces. There is a need to move away from criminalized approaches which shape unsafe work conditions and increase work stress for SWs. Policies that promote SWs' access to the same occupational health, safety and human rights standards as workers in other labour sectors are also needed.

  18. Work pressure is major cause of accidents at work

    NARCIS (Netherlands)

    Smulders, P.

    2004-01-01

    The work-related accident rate in the Netherlands is 6.4%. The highest rates were found in the construction and agricultural sectors and in the police force. Workers subject to heavy work and work pressure are shown to have an accident rate up to five times greater than for workers who seldom or

  19. The Process of Identity Work: Negotiating a Work Identity

    NARCIS (Netherlands)

    Crafford, A.; Adams, B.G.; Saayman, T.; Vinkenburg, C.J.; Jansen, P.G.W.; Roodt, G.

    2015-01-01

    Identity work is an important process in negotiating, regulating and maintaining a coherent sense of self-(identity). In this chapter we discuss how identity work is particularly useful in establishing a work identity. The crux of the discussion in this chapter is based on the qualitative phase of

  20. Work Ethic Characteristics: Perceived Work Ethics of Supervisors and Workers

    Science.gov (United States)

    Petty, Gregory C.; Hill, Roger B.

    2005-01-01

    The purpose of this study was to compare the work ethics of supervisors with that of the employees they manage. The study investigated the occupational work ethics of both workers and their supervisors in a variety of businesses and industries to determine if there was a significant difference in the work ethics of these two groups as measured by…

  1. Military Social Work: Opportunities and Challenges for Social Work Education

    Science.gov (United States)

    Wooten, Nikki R.

    2015-01-01

    Military social work is a specialized field of practice spanning the micro-macro continuum and requiring advanced social work knowledge and skills. The complex behavioral health problems and service needs of Iraq and Afghanistan veterans highlight the need for highly trained social work professionals who can provide militarily relevant and…

  2. Work teams and psychosocial risks and work stress

    NARCIS (Netherlands)

    Oeij, P.; Kraan, K.O.; Dhondt, S.

    2014-01-01

    Teamworking is a ‘double-edged sword’. On the one hand, teamworking has been recognised as a way of reducing work-related stress work-related stress by enhancing employees’ job autonomy. Conversely, there is a risk that teamworking could increase employee stress levels by enhancing work pressure.

  3. Identity at work: Exploring strategies for Identity Work

    Directory of Open Access Journals (Sweden)

    Byron G. Adams

    2012-01-01

    Full Text Available Orientation: This study explored strategies for identity work that are central to the negotiation and regulation of employee work identity.Research purpose: The main aim of this study was to explore employee narratives and identify the strategies available to them in the process of identity work, as they defined themselves at work.Motivation for the study: As there is a scarcity of research on identity work in South Africa, this study wanted to advance knowledge about identity work and the strategies used for regulating and negotiating an identity at work by exploring these constructs in this context.Research design, approach and method: A qualitative research process formed the basis for this study. Nineteen employees from a global manufacturing company participated in two semi-structured in-depth interviews. Grounded theory was applied to analyse and interpret the data.Main findings: Nine strategies for identity work were identified and categorised into four broad themes (personal philosophies; relationships; career management and negotiating balance.Practical/managerial implications: Employees followed various strategies for defining themselves at work and this may have some implications for employee work engagement and productivity.Contribution/value-add: This study expands on current theoretical knowledge of identity work, and provides insights into the strategies people use to regulate and negotiate their identities at work

  4. Social Work Learning Spaces: The Social Work Studio

    Science.gov (United States)

    Zufferey, Carole; King, Sue

    2016-01-01

    This paper explores the contribution of a physical learning space to student engagement in social work education. Drawing on a constructivist methodology, this paper examines the findings of a survey conducted with students and staff in a social work and human service programme about their experiences of a Social Work Studio learning space. The…

  5. Work outcomes of unhappy expatriates

    DEFF Research Database (Denmark)

    Selmer, Jan; Lauring, Jakob

    While some expatriates could feel deeply unhappy trying to deal with the challenges of living and working abroad, few rigorous academic studies have presented evidence of the association between unhappiness among expatriates and their work outcomes. That is surprising since performing certain work...... tasks is the reason for the foreign assignment. Based on the survey responses of 428 expatriate academics, results of this exploratory study show that subjective ill-being had a strong negative association with work adjustment, work performance, work effectiveness, job satisfaction as well as a strong...

  6. Phosphoric Acid Fuel Cells Test and Evaluation

    National Research Council Canada - National Science Library

    Unger, Robert J; Kenner, Scott; Binder, Michael J; Holcomb, Franklin H

    2004-01-01

    ...) Fuel Cell Technology Program facilitates the development of Fuel Cell Technology. This work provided testing and evaluations of fuel cells in support of life-cycle-cost reduction and performance improvement goals...

  7. Work environment factors and work sustainability in Norwegian cooks.

    Science.gov (United States)

    Svedahl, Sindre Rabben; Svendsen, Kristin; Romundstad, Pål R; Qvenild, Torgunn; Strømholm, Tonje; Aas, Oddfrid; Hilt, Bjørn

    2016-01-01

    Cooks have increased morbidity and mortality. A high turnover has also been reported. We aimed to elucidate work environment and work sustainability in Norwegian cooks. A questionnaire inquiring about working conditions and work participation was sent to 2082 cooks who had qualified from 1988 onwards. Of these, 894 responded. Time at work was analyzed with Kaplan-Meier plots and possible determinants for quitting work as a cook was analyzed with Cox regression. The median time at work was 16.6 years. There were differences in sustainability between types of kitchens for both sexes (p = 0.00). The median time in the profession was 9.2 years for the cooks in restaurants, while the cooks in institutions and canteens showed a substantially higher sustainability with 75.4% still at work after 10 years, and 57% still at work after 20 years in the profession. Of those still at work as a cook, 91.4% reported a good or very good contentment, and the 67.4% who expected to stay in the profession the next 5 years frequently answered that excitement of cooking, the social working environment, and the creative features of cooking were reasons to continue. Musculoskeletal complaints were the most common health-related reason for leaving work as a cook, while working hours was the most common non-health-related reason. There are significant differences in work sustainability between the cooks in the different types of kitchens. The identified determinants for length of time in the occupation can be used for preventive purposes. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  8. How Piercings and Tattooing Work

    Science.gov (United States)

    ... About skin: Your body's largest organ Piercings and tattoos: Cool or dangerous? How piercings and tattooing work "); ( ... bite and sting Eczema: Itchy skin Piercings and tattoos: Cool or dangerous? How piercings and tattooing work ...

  9. [Working conditions in operating rooms].

    Science.gov (United States)

    Kułagowska, Ewa

    2007-01-01

    The aim of this study was to get acquainted with the opinions of the nursing staff on working conditions at their workplace. The study was carried out in a group of 398 nurses working in various kinds of operating rooms at 11 public hospitals. A questionnaire was used as a major tool of this study. The questionnaires were filled in by 259 operating room nurses (circulating nurses) and 139 nurse-anesthetists. The collected data show that working conditions in operating rooms do not ensure safety of the nursing staff at work. The main sources of problems are: work organization, technical factors, work equipment, work space, knowledge of hazards and strenuous factors among nurses, ways of preventing and/or limiting them. These elements are serious occupational risk factors influencing the work process and health status of nurses.

  10. How Does a Pacemaker Work?

    Science.gov (United States)

    ... the NHLBI on Twitter. How Does a Pacemaker Work? A pacemaker consists of a battery, a computerized ... these recordings to adjust your pacemaker so it works better for you. Your doctor can program the ...

  11. Implementing New Ways of Working

    DEFF Research Database (Denmark)

    Granlien, Maren Sander; Hertzum, Morten

    2009-01-01

    Successful deployment of information technology (IT) involves implementation of new ways of working. Under-recognition of this organizational element of implementation entails considerable risk of not attaining the benefits that motivated deployment, yet knowledge of how to work systematically...

  12. Working mothers: Family-work conflict, job performance and family/work variables

    Directory of Open Access Journals (Sweden)

    Cynthia J Patel

    2006-02-01

    Full Text Available The present study examined the relationship between family-work conflict, job performance and selected work and family characteristics in a sample of working mothers employed at a large retail organization. The hypothesis of a negative relationship between family-work conflict and job performance was rejected. Married women reported significantly higher family-work conflict than unmarried women, while women in the highest work category gained the highest job performance rating. More than half the sample indicated that paid work was more important than their housework and reported that their working had a positive impact on their families. The findings are discussed in relation to the changing work and family identities of non-career women.

  13. Human Work Interaction Design. Work Analysis and HCI

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume. ......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications.......This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume....... The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability...

  14. Biopsychosocial correlates of work motivation

    OpenAIRE

    Liesienė, Justina; Endriulaitienė, Auksė

    2008-01-01

    Background, purpose. Work motivation is a potential predictor of employee turnover, job satisfaction, commitment, job performance and psychological wellbeing. Researchers argue that motivated employees work more effectively. The purpose of the current study was to identify biological (gender, age and health), psychological (personality traits) and social (marital status, children, work sector and position) factors related to employees’ work motivation. It was also predicted that subjectively...

  15. Biopsychosocial correlates of work motivation

    OpenAIRE

    Gaubė, Justina; Endriulaitienė, Auksė

    2008-01-01

    Work motivation is a potential predictor of employee turnover, job satisfaction, commitment, job performance and psychological wellbeing. Researchers argue that motivated employees work more effectively. The purpose of the current study was to identify biological (gender, age and health), psychological (personality traits) and social (marital status, children, work sector and position) factors related to employees’ work motivation. It was also predicted that subjectively perceived job effecti...

  16. Special working conditions of juveniles

    OpenAIRE

    Tomek, Pavel

    2010-01-01

    Resumé: In my rigorous work I dealt with the legal arrangement of the special working conditions of juveniles and minors. These conditions are being legally arranged since over two centuries. One of the characteristical signs in the development of this legal arrangement is enlarging the legal protection of working minors as well as of juveniles resulting namely in shortening the working hours for minors, determinations of the minimal age for taking a job, determinations of the obligatory scho...

  17. Work Engagement of Kindergarten Teachers

    OpenAIRE

    Nick, Riika

    2012-01-01

    The purpose of this study was to find out the factors of work engagement of kindergarten teachers and the elements of these factors. Work engagement is one part of work well-being. This final thesis was a qualitative study. The method for collecting data was theme interview, which is a qualitative study method. For this study I interviewed five kindergarten teachers. The data were analyzed by thematic analysis. As a theoretical framework I used work engagement, which is divided into three...

  18. Work environment factors and work sustainability in Norwegian cooks

    Directory of Open Access Journals (Sweden)

    Sindre Rabben Svedahl

    2016-02-01

    Full Text Available Objectives: Cooks have increased morbidity and mortality. A high turnover has also been reported. We aimed to elucidate work environment and work sustainability in Norwegian cooks. Material and Methods: A questionnaire inquiring about working conditions and work participation was sent to 2082 cooks who had qualified from 1988 onwards. Of these, 894 responded. Time at work was analyzed with Kaplan-Meier plots and possible determinants for quitting work as a cook was analyzed with Cox regression. Results: The median time at work was 16.6 years. There were differences in sustainability between types of kitchens for both sexes (p = 0.00. The median time in the profession was 9.2 years for the cooks in restaurants, while the cooks in institutions and canteens showed a substantially higher sustainability with 75.4% still at work after 10 years, and 57% still at work after 20 years in the profession. Of those still at work as a cook, 91.4% reported a good or very good contentment, and the 67.4% who expected to stay in the profession the next 5 years frequently answered that excitement of cooking, the social working environment, and the creative features of cooking were reasons to continue. Musculoskeletal complaints were the most common health-related reason for leaving work as a cook, while working hours was the most common non-health-related reason. Conclusions: There are significant differences in work sustainability between the cooks in the different types of kitchens. The identified determinants for length of time in the occupation can be used for preventive purposes.

  19. Work, organisational practices, and margin of manoeuver during work reintegration.

    Science.gov (United States)

    O'Hagan, Fergal

    2017-09-29

    Many individuals of working age experience cardiovascular disease and are disabled from work as a result. The majority of research in cardiac work disability has focused on individual biological and psychological factors influencing work disability despite evidence of the importance of social context in work disability. In this article, the focus is on work and organisational features influencing the leeway (margin of manoeuvre) workers are afforded during work reintegration. A qualitative method was used. A large auto manufacturing plant was selected owing to work, organisational, and worker characteristics. Workplace context was assessed through site visits and meetings with stakeholders including occupational health, human resources and union personnel and a review of collective agreement provisions relating to seniority, benefits and accommodation. Worker experience was assessed using a series of in-depth interviews with workers (n = 12) returning to work at the plant following disabling cardiac illness. Data was analysed using qualitative content analysis. Workers demonstrated variable levels of adjustment to the workplace that could be related to production expectations and work design. Policies and practices around electronic rate monitoring, seniority and accommodation, and disability management practices affected the buffer available to workers to adjust to the workplace. Work qualities and organisational resources establish a margin of manoeuver for work reintegration efforts. Practitioners need to inform themselves of the constraints on work accommodation imposed by work organisation and collective agreements. Organisations and labour need to reconsider policies and practices that creates unequal accommodation conditions for disabled workers. Implications for rehabilitation Margin of manoeuvre offers a framework for evaluating and structuring work reintegration programmes. Assessing initial conditions for productivity expectations, context and ways

  20. Youth Work Experience and Employability.

    Science.gov (United States)

    Hamilton, Stephen F.; And Others

    This paper examines the effects of youth work experience on subsequent employability. The paper begins with a speculative consideration of the ways in which work experience might affect later employability. Three types of research literature are then reviewed: (1) economic studies of the relation between youth work and subsequent employment and…

  1. Professors' Observations on Their Work.

    Science.gov (United States)

    Myers, Betty; Mager, Gerald M.

    Previous studies of professors of education have noted what activities comprised the work of being a professor, how professors allocated time to the various work tasks, how they would have preferred to allocate time, and insights they had about their work. In this study, parallel data were gathered on the broader education professoriate. Survey…

  2. Toward a Youth Work Profession

    Science.gov (United States)

    Emslie, Michael

    2013-01-01

    There is growing interest in the professionalization of the youth work field in Australia and the United States. In this article I draw on relevant literature from the sociology of professions to explore the appeal of professionalization for youth work. The interest in professionalism is examined along with the strategies youth work practitioners…

  3. Systematic Quality Work in Preschool

    Science.gov (United States)

    Sheridan, Sonja; Williams, Pia; Sandberg, Anette

    2013-01-01

    The purpose of this study was to investigate the meaning that Swedish preschool teachers ascribe to systematic quality work. In Sweden, all preschools are required to work systematically with quality issues. This involves several interdependent steps that follow each other in a specific order. Although the concept of systematic quality work might…

  4. Work shifts in Emergency Medicine

    Directory of Open Access Journals (Sweden)

    Roberto Recupero

    2007-06-01

    Full Text Available Emergency Medicine is known as a high stress specialty. The adverse effect of constantly rotating shifts is the single most important reason given for premature attrition from the field. In this work problems tied with night shift work will be taken into account and some solutions to reduce the impact of night work on the emergency physicians will be proposed.

  5. How Do Asthma Medicines Work?

    Science.gov (United States)

    ... a Kid Who's Bullied? How Do Asthma Medicines Work? KidsHealth > For Kids > How Do Asthma Medicines Work? Print A A A en español ¿Cómo funcionan ... control medicines (also called controller or maintenance medicines) work over a long period of time by keeping ...

  6. Sectoral profiles of working conditions

    NARCIS (Netherlands)

    Houtman, I.L.D.; Andries, F.; Berg, R. van den; Dhondt, S.

    2002-01-01

    This report looks at trends in working conditions across different sectors Over the period 1995-2000. Basing its findings on the Third European Survey on Working Conditions (2000) in the 15 EU Member States and Norway, it examines the quality of working life in eighteen different sectors. It

  7. Sectoral profiles of working conditions

    NARCIS (Netherlands)

    Houtman, I.L.D.; Parent-Thirion, A.

    2003-01-01

    This report looks at trends in working conditions across different sectors over a five-year period 1995-2000. Basing its findings on the Third European Survey on Working Conditions carried out by the Foundation in 2000 in the 15 EU Member States and Norway, it examines the quality of working life in

  8. Breastfeeding and returning to work

    OpenAIRE

    Public Health Agency

    2010-01-01

    This leaflet aims to encourage breastfeeding mothers to continue breastfeeding after they have returned to work. It highlights the benefits of continuing to breastfeed, sets out the options for combining breastfeeding and work, explains the rights breastfeeding mothers have to support from their employer, and outlines what facilities and equipment mothers will need to express milk at work.

  9. Shift Work: Improving Daytime Sleep

    Science.gov (United States)

    ... Good daytime sleep is possible, though, if shift work is a necessary part of your work life. To promote better sleep during the day: ... Take naps. Napping late in the day before work might help you make up your sleep debt. ...

  10. Work engagement: drivers and effects

    NARCIS (Netherlands)

    Bakhuys Roozeboom, M.M.C.; Schelvis, R.

    2014-01-01

    The concept of work engagement fits into the tradition of positive psychology, a recent paradigm shift in psychology which focuses on mental health rather than mental illness. This article gives an introduction to the concept of work engagement. Different definitions and viewpoints of the work

  11. Action research and Care Work

    DEFF Research Database (Denmark)

    Andersen, John; Bilfeldt, Anette

    The paper is a about planning and empowerment in care work at public nursing homes and the role of action research. It is based on ongoing work in the “Center for Demokratisk Samfundsudvikling og Aktionsforskning” at Roskilde University and the transnational research network KATARSIS, which works...

  12. Explorations in Social Work Education

    Science.gov (United States)

    Tie'er, Shi

    2013-01-01

    Social work education leans toward the applied approach emphasizing the practical and experiential. At present, many schools still offer social work education in the traditional academic model emphasizing textual learning. This approach is not suitable to the knowledge, student or teacher orientation in social work, and its pedagogy. To develop…

  13. Stem Cells

    Science.gov (United States)

    Stem cells are cells with the potential to develop into many different types of cells in the body. ... the body. There are two main types of stem cells: embryonic stem cells and adult stem cells. Stem ...

  14. Psychological context of work meaningfulness

    Directory of Open Access Journals (Sweden)

    Karel Paulík

    2014-12-01

    Full Text Available There is a significant shift of approach to the management of organizations and workers in recent decades. This shift in management philosophy is characterized by converting from traditional, conventional (rather bureaucratic management models to rather humanistic/existential oriented models. This transition comes partly from the understanding that human resources are the most promising and effective way for organization development, partly from a shift in the understanding of the role of organizations in society. The key point of these approaches has become a "meaning" or "meaningfulness" in relation to the work and organization. The importance of work meaningfulness is not only in its potential to increase the competitiveness of organizations, but especially in its major (mostly positive impacts on the employee himself and his work (and by that the organization and its performance. Work meaningfulness is strongly connected to the work engagement, which represents the active personal participation in the work process, manifested by vigor, active cooperation, willingness to contribute to the company's success and dedication to work. Work engagement seems to be next important factor affecting work attitudes and achievements of employees. The paper gives an overview of various approaches to work meaningfulness and work engagement, on the basis of which authors propose new model of work meaningfulness with overlap to work engagement. The work meaningfulness is not seen as one-dimensional variable, but consists of complex of interacting factors and processes that define an individual perceived meaning and importance of the work. Meaningful work is influenced by three areas. The first is the organizational culture. This is defined as a specific pattern of values, norms, beliefs, attitudes and assumptions that are often not clearly expressed, but affect the way individuals behave in an organization and how things are done. The second area is the work

  15. Quantitative methods for analyzing cell-cell adhesion in development.

    Science.gov (United States)

    Kashef, Jubin; Franz, Clemens M

    2015-05-01

    During development cell-cell adhesion is not only crucial to maintain tissue morphogenesis and homeostasis, it also activates signalling pathways important for the regulation of different cellular processes including cell survival, gene expression, collective cell migration and differentiation. Importantly, gene mutations of adhesion receptors can cause developmental disorders and different diseases. Quantitative methods to measure cell adhesion are therefore necessary to understand how cells regulate cell-cell adhesion during development and how aberrations in cell-cell adhesion contribute to disease. Different in vitro adhesion assays have been developed in the past, but not all of them are suitable to study developmentally-related cell-cell adhesion processes, which usually requires working with low numbers of primary cells. In this review, we provide an overview of different in vitro techniques to study cell-cell adhesion during development, including a semi-quantitative cell flipping assay, and quantitative single-cell methods based on atomic force microscopy (AFM)-based single-cell force spectroscopy (SCFS) or dual micropipette aspiration (DPA). Furthermore, we review applications of Förster resonance energy transfer (FRET)-based molecular tension sensors to visualize intracellular mechanical forces acting on cell adhesion sites. Finally, we describe a recently introduced method to quantitate cell-generated forces directly in living tissues based on the deformation of oil microdroplets functionalized with adhesion receptor ligands. Together, these techniques provide a comprehensive toolbox to characterize different cell-cell adhesion phenomena during development. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. SolidWorks Administration Bible

    CERN Document Server

    Lombard, Matt

    2009-01-01

    What you need to prepare, install, and maintain SolidWorks. It's not enough to know how to use SolidWorks, if your job also requires you to install or maintain it, train new users, and implement standards. This in-depth guide was written for those of you who have to actually manage your company's SolidWorks system. From hardware selection to helping users to licensing and more, this is the everyday, bread-and-butter SolidWorks administration resource that IT and CAD managers have been seeking.:; SolidWorks is a powerful 3D solid modeling system that is popular with CAD users everywhere, but of

  17. Neurocognitive architecture of working memory

    Science.gov (United States)

    Eriksson, Johan; Vogel, Edward K.; Lansner, Anders; Bergström, Fredrik; Nyberg, Lars

    2015-01-01

    The crucial role of working memory for temporary information processing and guidance of complex behavior has been recognized for many decades. There is emerging consensus that working memory maintenance results from the interactions among long-term memory representations and basic processes, including attention, that are instantiated as reentrant loops between frontal and posterior cortical areas, as well as subcortical structures. The nature of such interactions can account for capacity limitations, lifespan changes, and restricted transfer after working-memory training. Recent data and models indicate that working memory may also be based on synaptic plasticity, and that working memory can operate on non-consciously perceived information. PMID:26447571

  18. [Working conditions of community nurses].

    Science.gov (United States)

    Kułagowska, Ewa; Kosińska, Maria

    2010-01-01

    To ensure the most efficient workplace health promotion it is essential to identify and monitor health conditions of employees and all components of the work process, as well as to recognize their cause-effect relationships. Community nurses form an occupational group with a specific type of workplace that is usually located in the patient's place of residence and thus not inspected in terms of safety and hygiene. The aim of the study was to identify working conditions of community nurses with special reference to occupational hazards. An anonymous questionnaire was used as a major tool of this survey. It contained 33 questions, concerning the work process, working conditions, work loads and arduousness, hazards and work-related complaints. The questionnaire was completed by 86 community nurses working in the Upper Silesia region. Community nurses generally assessed their work as hard. A more thorough analysis revealed that nursing and curative care, nursing and hygienic care and rehabilitation were regarded by community nurses as hard, whereas social diagnostics and curative diagnostics were assessed as much easier tasks. Excessive physical load, forced position at work, aggressive patients, patients' aggressive family members, dangerous domestic animals, low quality of technical devices in patients' homes were reported as the greatest hazards. The obtained results reveal that working conditions of community nurses do not ensure their safety at work.

  19. Beyond Work-Life "Integration".

    Science.gov (United States)

    Williams, Joan C; Berdahl, Jennifer L; Vandello, Joseph A

    2016-01-01

    Research on the work-family interface began in the 1960s and has grown exponentially ever since. This vast amount of research, however, has had relatively little impact on workplace practice, and work-family conflict is at an all-time high. We review the work-family research to date and propose that a shift of attention is required, away from the individual experience of work and family and toward understanding how identity and status are defined at work. Several factors enshrine cherished identities around current workplace norms. The work devotion schema demands that those who are truly committed to their work will make it the central or sole focus of their lives, without family demands to distract them. Importantly, the work devotion schema underwrites valued class and gender identities: Work devotion is a key way of enacting elite class status and functions as the measure of a man--the longer the work hours and higher the demand for his attention, the better. Advocating change in the way work is done and life is lived meets resistance because it places these cherished identities at risk. Resistance to these identity threats keeps current workplace norms in place. This is why even the business case-which shows that current practices are not economically efficient-fails to persuade organizations to enact change. What is needed now is sustained attention to the implicit psychological infrastructure that cements the mismatch between today's workplace and today's workforce.

  20. Work activities within sustainable development

    Directory of Open Access Journals (Sweden)

    Francisco Duarte

    2015-06-01

    Full Text Available This paper presents the main results of a Franco-Brazilian Research project entitled "Work, Innovation and Development". The aim is to conceptually consider work activity within sustainable development, and to contribute methodologically towards developing strategies for designing sustainable work systems. After a brief description of the factors and the dimensions that have contributed to the creation of ideas on sustainable development, we will put forward two main approaches for understanding work activity within the context of sustainability, these being: the durability of work activity and the development of work activities for sustainable development. Both approaches are presented and examples are given. This is followed by a discussion of the design of sustainable work systems that focuses particularly on the political and technical dimensions of project management.

  1. Increasing work-time influence

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Garde, Anne Helene; Aust, Birgit

    2012-01-01

    This quasi-experimental study investigated how an intervention aiming at increasing eldercare workers' influence on their working hours affected the flexibility, variability, regularity and predictability of the working hours. We used baseline (n = 296) and follow-up (n = 274) questionnaire data......-operation with colleagues. In subgroup B and C, the participants ended up discussing the potential consequences of more work-time influence without actually implementing any changes. PRACTITIONER SUMMARY: Employee work-time influence may buffer the adverse effects of shift work. However, our intervention study suggested...... that while increasing the individual flexibility, increasing work-time influence may also result in decreased regularity of the working hours and less continuity in the care of clients and co-operation with colleagues....

  2. Work environment and school dropout

    DEFF Research Database (Denmark)

    Hansen, Claus D.; Andersen, Johan Hviid; Lund, Thomas

    Aim The aim of this presentation is to examine the possible impact of work environment (and especially psychosocial work environment) on school dropout. The questions raised are: to what extent do psychosocial work environment and especially the social relations between young apprentices...... and their colleagues and managers play a role in dropping out of upper secondary education? Methods A cohort of 3058 adolescents born in 1989 and a cohort of approximately 2000 young adults born in 1983 are used to examine the associations between work environment and subsequent dropout in upper secondary educational...... indicated that ‘being treated badly by superior’ was part of the reason for doing so. Further analyses show that reporting repetitive and monotonous work tasks increases the risk of dropping out (OR: 1.74) and that reporting bad working climate at ones work place increases the risk of considering...

  3. Unskilled Work and Learner Identity

    DEFF Research Database (Denmark)

    Kondrup, Sissel

    2014-01-01

    The paper examines how unskilled work forms conditions for meeting the obligation to position oneself as an educable subject and engage in formal learning activities. Sensitivity to peoples’ work-life-experiences is necessary to understand their orientation toward different learning activities...... a critical theoretical approach inspired by Salling-Olesen’s and Archer’s concepts of identity and concerns can contribute to an understanding of the relationship between work and learner identity. Through narrative work-life interviews I examine how engagement in unskilled work in small and medium sized....... The main argument is that participation research must abandon the notion of motivation as an individual attribute and apply a dialectic concept of learner identity acknowledging work-life as a pivotal space for learning and formation of identity. I outline how a work-life-historical approach combining...

  4. Unskilled Work and Learner Identity

    DEFF Research Database (Denmark)

    Kondrup, Sissel

    The paper examines how unskilled work forms conditions for meeting the obligation to position oneself as an educable subject and engage in formal learning activities. Sensitivity to peoples’ work-life-experiences is necessary to understand their orientation toward different learning activities...... a critical theoretical approach inspired by Salling- Olesen’s and Archer’s concepts of identity and concerns can contribute to an understanding of the relationship between work and learner identity. Through narrative work-life interviews I examine how engagement in unskilled work in small and medium sized....... The main argument is that participation research must abandon the notion of motivation as an individual attribute and apply a dialectic concept of learner identity acknowledging work-life as a pivotal space for learning and formation of identity. I outline how a work-life-historical approach combining...

  5. Shift work, long working hours, and later risk of dementia

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Garde, AH; Ishtiak-Ahmed, K

    2017-01-01

    –1971 and 1985–1986), long working hours defined as >45 hours per week (collected in 1970–1971), socioeconomic status, sleep, stress, and cardiovascular risk factors. Information about dementia diagnoses was obtained from registers. Participants were followed until 2014 (mean length of follow-up was 17.8 years......Objectives: The aim of this study was to investigate the effect of shift work and long working hours in midlife on the risk of dementia in old age. Methods: The present study comprised 4766 participants from the Copenhagen Male Study. We used information on shift work (collected in 1970......). We employed Poisson regression for the survival analyses and estimated incidence rate ratios (IRR) and their 95% confidence intervals (CI). Results: We found no statistically significant association between shift work (IRR 0.86, 95% CI 0.70–1.05) or long working hours (IRR 0.97, 95% CI 0...

  6. Work engagement and meaningful work across generational cohorts

    Directory of Open Access Journals (Sweden)

    Crystal Hoole

    2015-03-01

    Full Text Available Orientation: Engaging employees and providing employees with a sense of meaning at work is not a one-size-fits-all approach. Although research has shown that differences between work engagement and meaningful work amongst generational cohorts exist, results are still inconclusive. With age becoming increasingly more important as a diversity factor, a better understanding of the dynamics between work engagement and meaningful work across different generational cohorts is necessary to design the right strategy for each organisation’s unique parameters.Research purpose: The aim of this study was to determine whether there is a relationship between work engagement and meaningful work and whether there are significant variances between the levels of work engagement and meaningful work between different generational cohorts.Motivation for study: Work engagement has consistently been highlighted by researchers and human resources experts as a recommended solution to provide companies with the upper hand when it comes to creating a competitive edge. Yet, levels of work engagement are far from ideal, requiring intensified efforts to identify solutions towards raising overall engagement levels. In recent years, much of the focus in terms of generating engagement has been aimed in the direction of financial rewards and other benefits; some organisational experts are of the opinion that a shift is occurring towards meaningful work instead of monetary rewards as the driver of engagement. The changing nature of the work landscape also suggests that generational cohorts experience work engagement and meaningful work differently. Understanding these complexities is mandatory in creating solutions towards improving levels of engagement and meaningful work.Research approach, design and method: A cross-sectional quantitative research approach has been followed. The Utrecht Work Engagement Scale (UWES and Psychological Meaningful Scale (PMS were administered to

  7. Changing Work and Work-Family Conflict: Evidence from the Work, Family, and Health Network*

    OpenAIRE

    Kelly, Erin L.; Moen, Phyllis; Oakes, J. Michael; Fan, Wen; Okechukwu, Cassandra; Davis, Kelly D.; Hammer, Leslie; Kossek, Ellen; King, Rosalind Berkowitz; Hanson, Ginger; Mierzwa, Frank; Casper, Lynne

    2014-01-01

    Schedule control and supervisor support for family and personal life are work resources that may help employees manage the work-family interface. However, existing data and designs have made it difficult to conclusively identify the effects of these work resources. This analysis utilizes a group-randomized trial in which some units in an information technology workplace were randomly assigned to participate in an initiative, called STAR, that targeted work practices, interactions, and expecta...

  8. Human Work Interaction Design. Work Analysis and HCI

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume. ......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications....

  9. Military Social Work: Opportunities and Challenges for Social Work Education

    OpenAIRE

    Wooten, Nikki R.

    2015-01-01

    Military social work is a specialized field of practice spanning the micro-macro continuum and requiring advanced social work knowledge and skills. The complex behavioral health problems and service needs of Iraq and Afghanistan veterans highlight the need for highly trained social work professionals who can provide militarily-relevant and culturally-responsive evidence-informed services. Responding to the military behavioral health workforce and service needs of recently returned veterans pr...

  10. Working hours and Work-Life Balance Satisfaction in Couples

    OpenAIRE

    Georges, Nathalie; Méda, Dominique; Trancart, Danièle

    2010-01-01

    Over the past several years, many studies have highlighted the strategic nature of working hours, the way they are determined, their regularity and their predictability to judge the qualities of a job and how family life and work life are reconciled. Our results confirm those obtained by previous studies and clarify them, while also showing that both the working hours of the persons questioned and those of their spouse constitute a central variable. We will first review the results from the a...

  11. Does Working from Home Work? Evidence from a Chinese Experiment

    OpenAIRE

    Nicholas Bloom; James Liang; John Roberts; Zhichun Jenny Ying

    2013-01-01

    A rising share of employees now regularly engage in working from home (WFH), but there are concerns this can lead to "shirking from home". We report the results of a WFH experiment at Ctrip, a 16,000-employee, NASDAQ-listed Chinese travel agency. Call center employees who volunteered to WFH were randomly assigned either to work from home or in the office for nine months. Home working led to a 13% performance increase, of which 9% was from working more minutes per shift (fewer breaks and sick ...

  12. Work, work-life conflict and health in an industrial work environment.

    Science.gov (United States)

    Hämmig, O; Bauer, G F

    2014-01-01

    Work-life conflict has been poorly studied as a cause of ill-health in occupational medicine. To study associations between physical and psychosocial working conditions, including work-life conflict on the one hand and general, physical and mental health outcomes on the other. Cross-sectional data were used from an employee survey among the workforces of four medium-sized and large companies in Switzerland. Physical work factors included five demands and exposures such as heavy loads, repetitive work and poor posture. Psychosocial factors included 14 demands and limited resources such as time pressure, overtime, monotonous work, job insecurity, low job autonomy, low social support and work-life conflict. Health outcomes studied were self-rated health, sickness absence, musculoskeletal disorders, sleep disorders, stress and burnout. There was a response rate of 49%; 2014 employees participated. All adverse working conditions were positively associated with several poor health outcomes in both men and women. After mutual adjustment for all work factors and additional covariates, only a few, mainly psychosocial work factors remained significant as risk factors for health. Work-life conflict, a largely neglected work-related psychosocial factor in occupational medicine, turned out to be the only factor that was significantly and strongly associated with all studied health outcomes and was consistently found to be the strongest or second strongest of all the studied risk factors. Even in an industrial work environment, psychosocial work factors, and particularly work-life conflict, play a key role and need to be taken into consideration in research and workplace health promotion.

  13. Impact of work pressure, work stress and work-family conflict on firefighter burnout.

    Science.gov (United States)

    Smith, Todd D; DeJoy, David M; Dyal, Mari-Amanda Aimee; Huang, Gaojian

    2017-10-25

    Little research has explored burnout and its causes in the American fire service. Data were collected from career firefighters in the southeastern United States (n = 208) to explore these relationships. A hierarchical regression model was tested to examine predictors of burnout including sociodemographic characteristics (model 1), work pressure (model 2), work stress and work-family conflict (model 3) and interaction terms (model 4). The main findings suggest that perceived work stress and work-family conflict emerged as the significant predictors of burnout (both p burnout among firefighters.

  14. [Difficulties at work and work motivation of ulcerative colitis suffers].

    Science.gov (United States)

    Nasu, Ayami; Yamada, Kazuko; Morioka, Ikuharu

    2015-01-01

    Because ulcerative colitis (UC) repeats remission and relapse, it is necessary to keep the condition at the relapse time in mind when considering support to provide UC suffers with at the workplace. The aim of this survey was to clarify the difficulties at work and work motivation that UC suffers feel at present and experience at the worsening time, and the factors for maintaining work motivation. We carried out an anonymous questionnaire survey of patients with present or past work experience. The difficulties at work (17 items) and work motivation (4 items) in the past week and at the time when the symptoms were most intensive during work were investigated using a newly designed questionnaire. We regarded the time in the past week as the present, and the time when the symptoms were most intensive during work as the worsening time. There were 70 respondents (response rate 32.0%). Their mean age was 43.8 years, and their mean age at onset was 33.8 years. All subjects, except 2 subjects after surgery, took medicine. Fifty-three (75.7%) of the subjects were in remission at the present, and most of them (91.4%) managed their physical condition well. Difficulties at work that many subjects worried about at the present were relevant to work conditions, such as "Others at workplace do not understand having an intractable and relapsing disease" (41.4%) or "Feel delayed or lack of chance of promotion or career advancement due to the disease" (38.6%). At the worsening time, the management of physical condition went wrong, and the frequency of hospital visits was increased, but few subjects consulted with superiors or colleagues at workplace. Difficulties at work that many subjects underwent at the worsening time were relevant to symptoms, such as "Feel physically tired" (80.0%) or "Decline foods or alcoholic beverages offered at business parties" (72.9%). Those who maintained work motivation even at the worsening time received no work-related consideration and had an

  15. Women's work and health in Iran: a comparison of working and non-working mothers.

    Science.gov (United States)

    Ahmad-Nia, Shirin

    2002-03-01

    This paper analyses research on the impact of work on mothers' health in Tehran (Iran) within a role analytic framework. A survey was conducted of a representative sample of working and non-working mothers in Tehran in 1998 (N = 1065, 710 working mothers, and 355 non-working mothers). Three main explanatory factors were examined (socio-demographic, work and work-related, and social-life context variables) alongside a range of mental and physical health outcome variables. Unlike in the West, where women's paid work is generally associated with better health, statistically significant differences between working and non-working women were not found in Tehran. It is argued that this is a result of the counter-balance of the positive and negative factors associated with paid work, such as increased stress on one hand and self-esteem on the other. Iranian society's particular socio-cultural climate has contributed to this finding, with its dominant gender-role ideology; the priority and extra weight placed on women's traditional roles as wives and mothers, and the remarkably influential impact of husbands' attitudes on women's health.

  16. Work Attitudes and Work Ethic as Predictors of Work Engagement among Polish Employees

    Directory of Open Access Journals (Sweden)

    Czerw Agnieszka

    2015-12-01

    Full Text Available The purpose of this study was to investigate the relationship between work engagement and the psychological traits of employees, such as attitudes towards work and work ethic. Additionally, the study included demographic characteristics of employees and organizational characteristics. Research was conducted using the Polish adaptations of two well known methods: Multidimensional Work Ethic Profile and Utrecht Work Enagagement Scale, as well as the Work Attitude Questionnaire (WAQ - a new Polish method. 360 adult employees of two large Polish regions took part in the study. The analysis showed a significant influence of hedonic-autotelic attitude, as well as four dimensions of work ethic on work engagement. It seems to be an important conclusion that work engagement turned out to be far more determined by the subject’s psychological traits than demographic and organizational ones. These results, indicating the special role of the perception of work as a central value, can be used only in the area of attitudes towards work formed during adolescence (e.g., at school, in career counseling but also in the area of motivating the employees by the organization.

  17. Working at Getting to Work: Negotiating Transportation and Low-Wage Work in Rural Michigan

    Directory of Open Access Journals (Sweden)

    E. Brooke Kelly

    2013-10-01

    Full Text Available This article examines the efforts that low-income mothers go through to get to work in two rural Michigan county contexts. The author relies on qualitative, in-depth interview data with one group of Latina mothers, who worked in agricultural labor often migrating with their families, and another group of white settled mothers in a county dominated by service jobs. Their accounts reveal the backstage labor needed to get to low-wage jobs in rural areas. Commuting, moving, and/or migrating necessitate much effort and planning. Without public transportation, mothers often "scramble" with unreliable, and often unsafe, vehicles. They also rely on friends and family members, negotiate with employers, coordinate their journey to work with the schedules of family members, and take risks to get to work. Programs and policies that provide assistance with reliable transportation, child care, and work and family balance should reduce the work of getting to work.

  18. Recent work on material interface reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Mosso, S.J.; Swartz, B.K. [Los Alamos National Lab., NM (United States)

    1997-12-31

    For the last 15 years, many Eulerian codes have relied on a series of piecewise linear interface reconstruction algorithms developed by David Youngs. In a typical Youngs` method, the material interfaces were reconstructed based upon nearly cell values of volume fractions of each material. The interfaces were locally represented by linear segments in two dimensions and by pieces of planes in three dimensions. The first step in such reconstruction was to locally approximate an interface normal. In Youngs` 3D method, a local gradient of a cell-volume-fraction function was estimated and taken to be the local interface normal. A linear interface was moved perpendicular to the now known normal until the mass behind it matched the material volume fraction for the cell in question. But for distorted or nonorthogonal meshes, the gradient normal estimate didn`t accurately match that of linear material interfaces. Moreover, curved material interfaces were also poorly represented. The authors will present some recent work in the computation of more accurate interface normals, without necessarily increasing stencil size. Their estimate of the normal is made using an iterative process that, given mass fractions for nearby cells of known but arbitrary variable density, converges in 3 or 4 passes in practice (and quadratically--like Newton`s method--in principle). The method reproduces a linear interface in both orthogonal and nonorthogonal meshes. The local linear approximation is generally 2nd-order accurate, with a 1st-order accurate normal for curved interfaces in both two and three dimensional polyhedral meshes. Recent work demonstrating the interface reconstruction for curved surfaces will /be discussed.

  19. Work for Passion or Money?

    DEFF Research Database (Denmark)

    Bille, Trine; Løyland, Knut; Holm, Anders

    2017-01-01

    adds to the literature by estimating the significance of these various income sources on the time allocated to arts work, non-arts work, and leisure. The results provide convincing evidence for the work-preference model, and ad hoc evidence shows that art grants have a significant positive effect......This paper assesses the relative impact of work for money or work for passion on Norwegian artists by examining artists’ labor supply. Our contribution is twofold. The first is to test the work-preference model and the second is to investigate the impact of arts grants on artists’ labor supply....... The empirical specification draws two distinctions: between arts and non-arts income and between labor and non-labor income. Non-labor income is divided into three different sources: (1) spouse's income, (2) income from financial assets and social benefits, and (3) arts grants and subsidies. Our contribution...

  20. [Work-Related Medical Rehabilitation].

    Science.gov (United States)

    Bethge, M

    2017-02-01

    Work-related medical rehabilitation (WMR) is a strategy to improve work participation in patients with poor work ability. This review summarizes the state of knowledge on WMR. The prevalence of poor work ability and corresponding need for WMR is high (musculoskeletal disorders: 43%; mental disorders: 57%). The meta-analysis of randomized controlled trials in patients with musculoskeletal disorders shows better return to work outcomes after one year in favor of WMR patients than compared to patients participating in usual medical rehabilitation. The amount of work-related measures in rehabilitation was clearly increased during recent years. A direct involvement of the workplace and a closer cooperation with employers and occupational health physicians may further improve the outcomes of WMR. © Georg Thieme Verlag KG Stuttgart · New York.

  1. It Worked There. Will It Work Here? Researching Teaching Methods

    Science.gov (United States)

    Davis, Andrew

    2017-01-01

    "It worked there. Will it work here?" We have to be able to identify the "it" in that aphoristic question. Classifications of teaching methods belong in the social realm, where human intentions play a fundamental role in how phenomena are categorized. The social realm is characterized with the help of John Searle. Social…

  2. Globalization and working time: working hours and flexibility in Germany

    NARCIS (Netherlands)

    Burgoon, B.; Raess, D.

    2009-01-01

    This article challenges popular wisdom that economic globalization uniformly increases working time in industrialized countries. International investment and trade, they argue, have uneven effects for workplace bargaining over standard hours and over work-time flexibility, such as use of temporary

  3. Een internationale bachelor Social Work : eindrapportage internationale bachelor Social Work

    NARCIS (Netherlands)

    Frank Salemans

    2006-01-01

    Vergelijkende Europese studie in opdracht van Kees van Aken, toenmalig directeur van de opleiding Social Work i.o. van de Hogeschool Zuyd, naar welke verschillende varianten er mogelijk zijn als er gesproken wordt over een Internationale Bachelor Social Work - Maastricht. Op welke manieren zijn er

  4. Callings, work role fit, psychological meaningfulness and work ...

    African Journals Online (AJOL)

    Our aim in this study was to investigate the relationships among a calling orientation, work role fit, psychological meaningfulness and work engagement of teachers in Zambia. A quantitative approach was followed and a cross-sectional survey was used. The sample (n = 150) included 75 basic and 75 secondary school ...

  5. Mobile work: Ergonomics in a rapidly changing work environment.

    Science.gov (United States)

    Honan, Meg

    2015-01-01

    Places of work have been completely transformed by innovations in mobile work tools and ever-present access to internet data. This article characterizes use patterns and provides preliminary considerations for productive and comfortable use of common mobile devices. Two surveys described trends in mobile work. In the first, ergonomics professionals who oversee programs reported common mobile devices, their users and what data is accessed. The second, an end user survey, explored common activities performed on mobile devices, duration of use and locations where mobile work is common. The survey results provide a baseline data point for the status of mobile work in early 2014. Research indicates that additional risks have been introduced to the neck, thumbs and hands when using mobile devices. Possible trends regarding device use and work locations emerge. Intervention studies provide some direction for the practitioner. Practical strategies are outlined to reduce exposure intensity and duration. Contemporary mobile work presents tremendous change and opportunity for ergonomists and researchers to keep pace with fitting the changing models of work to the person. Continued research is needed on current mobile device use patterns to better understand ergonomic risk exposure in this rapidly changing realm.

  6. Human Work Interaction Design. Work Analysis and HCI

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume. ...

  7. What's Working in Working Memory Training? An Educational Perspective

    Science.gov (United States)

    Redick, Thomas S.; Shipstead, Zach; Wiemers, Elizabeth A.; Melby-Lervåg, Monica; Hulme, Charles

    2015-01-01

    Working memory training programs have generated great interest, with claims that the training interventions can have profound beneficial effects on children's academic and intellectual attainment. We describe the criteria by which to evaluate evidence for or against the benefit of working memory training. Despite the promising results of initial…

  8. ASSESSMENT OF WORK-SPACE AND WORK-METHOD DESIGNS ...

    African Journals Online (AJOL)

    related injuries among its workforce. This research assessed work-space (WsD) and work-method designs (WmD), level of compliance with recommended standards (RSs) and effects on workers' wellbeing. Clearances for services in 55 supine ...

  9. Renovation work at Restaurant 1

    CERN Multimedia

    2006-01-01

    Due to the age of the present kitchen and freeflow installations in Restaurant 1, essential renovation work is due to be carried out. The work is scheduled to last from September 2006 to May 2007. Work on the self-service area of the restaurant will commence in November. Every effort will be made to minimise the inconvenience caused to users of the restaurant and we thank you in advance for your co-operation during this period.

  10. Equality Work in Finnish Ministries

    OpenAIRE

    Tanhua, Inkeri

    2015-01-01

    The aim of this thesis is to contribute to knowledge about the equality work in public sector organisations. Especially, my aim is to bring light into everyday experiences of doing equality work. This is achieved through interviewing equality workers in Finnish ministries. The study draws also on my personal experiences as an equality consultant. The main question I ask is: Which issues influence the content of equality work? According to feminist research, promoting equality is always a poli...

  11. Human Work Interaction Design. Work Analysis and HCI

    DEFF Research Database (Denmark)

    Lopes, Arminda; Ørngreen, Rikke

    . The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability......This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications....

  12. Human Work Interaction Design. Work Analysis and HCI

    DEFF Research Database (Denmark)

    Paasch, Kasper

    2013-01-01

    . The papers reflect many different areas and address many complex and diverse work domains, ranging from medical user interfaces, work and speech interactions at elderly care facilities, greenhouse climate control, navigating through large oil industry engineering models, crisis management, library usability......This book constitutes the thoroughly refereed post-conference proceedings of the Third IFIP WG 13.6 Working Conference on Human Work Interaction Design, HWID 2012, held in Copenhagen, Denmark, in December 2012. The 16 revised papers presented were carefully selected for inclusion in this volume......, and mobile probing. They have been organized in the following topical sections: work analysis: dimensions and methods; interactions, models and approaches; and evaluations, interactions and applications....

  13. Work flow analysis: eliminating non-value-added work.

    Science.gov (United States)

    Capuano, Terry; Bokovoy, Joanna; Halkins, Deborah; Hitchings, Kim

    2004-05-01

    To evaluate the impact of implemented work environment changes on nursing and support staff roles. In 1999, the authors identified key drivers of unnecessary work associated with the day-to-day delivery of patient care in their institution and implemented changes based on their results. Both quantitative and qualitative methods were used. Work sampling and focus groups were used to evaluate work flow. Activity categories were identified and clearly defined by advanced practice nurses. All compiled data were subsequently synthesized and cross-checked with the information acquired through independent, multidisciplinary validation studies. There were significant changes (P <.0001) noted in overall distribution of observed activities for nurses and all support staff. The significant changes noted in overall distribution of observed activities reflect the important adjustments made in both job descriptions and the environment to eliminate key drivers of unnecessary work in the delivery of patient care.

  14. Staggered Bargaining and Hours Worked

    OpenAIRE

    Samuel Danthine; Stephane Auray

    2004-01-01

    A matching model with labor/leisure choice and staggered bargaining is used to explain (i)differences in GDP per hour and GDP per capita, (ii) differences in employment, (iii) differences in the proportion of part-time work across countries. The model predicts that the higher the level of rigidity in wages and hours the lower are GDP per capita, employment, part-time work and hours worked, but the higher is GDP per hours worked. In addition, it predicts that a country with a high level of rig...

  15. Bargaining frictions and hours worked

    OpenAIRE

    Stéphane AURAY; Danthine, Samuel

    2005-01-01

    A matching model with labor/leisure choice and bargaining frictions is used to explain (i) differences in GDP per hour and GDP per capita, (ii) differences in employment, (iii) differences in the proportion of part-time work across countries. The model predicts that the higher the level of rigidity in wages and hours the lower are GDP per capita, employment, part-time work and hours worked, but the higher is GDP per hours worked. In addition, it predicts that a country with a high level of ri...

  16. Working Conditions, Lifestyles and Health

    DEFF Research Database (Denmark)

    Cottini, Elena; Ghinetti, Paolo

    The aim of this paper is to investigate whether employee health is affected by the environment in which the individual works - in terms of both physical and psychosocial working conditions - and by his or her lifestyle. Health measures are computed from Danish data, and refer to both self assessed...... general health and two more objective health measures: mental health specific to work-related problems, and physical health. We find that both bad working conditions and bad lifestyles reduce health, especially in its self-assessed component. The impact of lifetsyle indicators have a more modest health...

  17. [Work-related stress urticaria].

    Science.gov (United States)

    Landex, Nadia Lander

    2016-12-12

    A medical doctor occasionally experienced itching papular exanthema during work hours. Careful history taking and a diary of symptoms demonstrated an association between the urticaria and stressful work situations. Urticaria can have many triggers, and stress is among the well-known triggers. The usual treatment of urticaria consists of avoiding triggers and, if necessary, antihistamines. Whereas it might be difficult to follow these recommendations in the case of work-related urticaria, the disorder may be perceived as a reminder of work situations which are going awry.

  18. Skeletal muscle satellite cells

    Science.gov (United States)

    Schultz, E.; McCormick, K. M.

    1994-01-01

    of control is to determine which of the many growth factors that can alter satellite cell behavior in vitro are at work in vivo. Little work has been done to determine what controls are at work after a regeneration response has been initiated. It seems likely that, after injury, growth factors are liberated through proteolytic activity and initiate an activation process whereby cells enter into a proliferative phase. After myofibers are formed, it also seems likely that satellite cell behavior is regulated through diffusible factors arising from the fibers rather than continuous control by circulating factors.(ABSTRACT TRUNCATED AT 400 WORDS).

  19. Interprofessional Cooperation as Collective Ethics Work

    NARCIS (Netherlands)

    François Gillet; dr Ed de Jonge

    2015-01-01

    Sarah Banks (2012) describes ethics work mainly as the effort people put into developing themselves as good practitioners. She discerns six aspects of ethics work: identity work, framing work, reason work, emotion work, role work and performance work. Although ethics work focuses on the ethical

  20. [Investigating work, age, health and work participation in the ageing work force in Germany].

    Science.gov (United States)

    Ebener, M; Hasselhorn, H M

    2015-04-01

    Working life in Germany is changing. The work force is ageing and the number of people available to the labour market will - from now on - shrink considerably. Prospectively, people will have to work longer; but still today, most people leave employment long before reaching official retirement age. What are the reasons for this? In this report, a conceptual framework and the German lidA Cohort Study are presented. The "lidA conceptual framework on work, age, health and work participation" visualises determinants of employment (11 "domains") in higher working age, e. g., "work", "health", "social status" and "life style". The framework reveals 4 key characteristics of withdrawal from work: leaving working life is the result of an interplay of different domains (complexity); (early) retirement is a process with in part early determinants in the life course (processual character); retirement has a strong individual component (individuality); retirement is embedded in a strong structural frame (structure). On the basis of this framework, the "lidA Cohort Study on work, age, health and work participation" (www.lida-studie.de) investigates long-term effects of work on health and work participation in the ageing work force in Germany. It is the only large study in Germany operationalising the concept of employability in a broad interdisciplinary approach. Employees subject to social security and born in 1959 or in 1965 will be interviewed (CAPI) every 3 years (N[wave 1]=6 585, N[wave 2]=4 244) and their data will be linked (where consented) with social security data covering employment history and with health insurance data. The study design ("Schaie's most efficient design") allows for a tri-factor model that isolates the impact of age, cohort and time. In 2014, the second wave was completed. In the coming years lidA will analyse the association of work, health and work participation, and identify age as well as generation differences. lidA will investigate the

  1. The profound precariousness of work through temporary work agency

    Directory of Open Access Journals (Sweden)

    Mihaela-Emilia Marica

    2016-12-01

    Full Text Available The increase in the number of atypical work contracts in the field of industry relationships, as part of a major European trend towards gaining more flexibility in the labour market, is significant and cannot be overlooked in most member countries of the European Union. This finding is corroborated by the recent surveys conducted across Europe, that reveal the prevalence of these flexible ways of organizing work, over the archetypal template of the individual work contract. However, this range of atypical contractual arrangements and the great number of versions and subcategories they include, are describing a number of negative features that seem to characterize these new forms of employment. Since the field of atypical employment is complex and we cannot analyse the incidence of these negative effects for all the atypical methods of employment, in the following article we will limit ourselves to explore the pressing issues related to the system of temporary work through work agencies. As we shall see, all aspects of the salary field, of health and safety at work and the level of insecurity and instability of labour through temporary work agency reveals a strong character associated with this kind of precarious employment.

  2. Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party

    Directory of Open Access Journals (Sweden)

    Marie Thérèse Rubio

    2017-01-01

    Full Text Available Abstract Background The impact of the use of anti-thymocyte globulin (ATG in allogeneic stem cell transplantation performed with HLA-identical sibling donors following fludarabine and 4 days intravenous busulfan myeloablative conditioning regimen has been poorly explored. Methods We retrospectively analyzed 566 patients who underwent a first HLA-identical allogeneic stem cell transplantation with this conditioning regimen for acute myeloid leukemia in first complete remission between 2006 and 2013 and compared the outcomes of 145 (25.6% patients who received ATG (ATG group to 421 (74.4% who did not (no-ATG group. The Kaplan-Meier estimator, the cumulative incidence function, and Cox proportional hazards regression models were used where appropriate. Results Patients in the ATG group were older, received more frequently peripheral blood stem cell grafts from older donors, and were transplanted more recently. With a median follow-up of 19 months, patients in the ATG group had reduced 2-year cumulative incidence of chronic graft-versus-host disease (GVHD (31 vs. 52%, p = 0.0002 and of its extensive form (8 vs. 26%, p < 0.0001 but similar relapse incidence (22 vs. 27%, p = 0.23 leading to improved GVHD and relapse-free survival (GRFS (60 vs. 40%, p = 0.0001. In multivariate analyses, the addition of ATG was independently associated with lower chronic GVHD (HR = 0.46, p = 0.0001, improved leukemia-free survival (HR = 0.67, p = 0.027, overall survival (HR = 0.65, p = 0.027, and GRFS (HR = 0.51, p = 4 × 10−5. Recipient age above 50 years was the only other factor associated with worse survivals. Conclusions These results suggest that the use of ATG with fludarabine and 4 days intravenous busulfan followed by HLA-identical sibling donor allogeneic stem cell transplantation for acute myeloid leukemia improves overall transplant outcomes due to reduced incidence of chronic GVHD without increased

  3. Strategies for Successful Group Work

    Science.gov (United States)

    Nipp, Mary Beth; Palenque, Stephanie Maher

    2017-01-01

    The thought of group work, or CLC Groups often strikes fear and loathing in the hearts and minds of both students and instructors. According to Swan, Shen, and Hiltz (2006) collaborative work presents the possibilities of many difficulties including a largely unequal contribution of group participants, an inability of the students to manage the…

  4. Work, environment and reproductive health

    NARCIS (Netherlands)

    C.A. Snijder (Claudia)

    2012-01-01

    textabstractWith the increasing labour force participation among women in Western countries, many women will work during their reproductive years. This will increase the likelihood that women during their reproductive years will be exposed to a variety of risk factors at work that may

  5. FY 1994 Annual Work Plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    This is the third Office of Inspector General (OIG)Annual Work Plan. Its purpose is to summarize work completed in Fiscal Year (FY) 1993, identify ongoing projects from previous fiscal years which the OIG intends to continue into FY 1994, and announce planned projects which the OIG intends to begin in FY 19994.

  6. Work, Experience and Adult Education

    DEFF Research Database (Denmark)

    Rasmussen, Palle

    2006-01-01

    A presentation and discussion of the theories of work, experience and adult education developed by the German philosopher and sociologist Oskar Negt.......A presentation and discussion of the theories of work, experience and adult education developed by the German philosopher and sociologist Oskar Negt....

  7. Group Work with Transgender Clients

    Science.gov (United States)

    Dickey, Lore M.; Loewy, Michael I.

    2010-01-01

    Drawing on the existing literature, the authors' research and clinical experiences, and the first author's personal journey as a member and leader of the transgender community, this article offers a brief history of group work with transgender clients followed by suggestions for group work with transgender clients from a social justice…

  8. Working with the News Media.

    Science.gov (United States)

    Ordovensky, Pat; Marx, Gary

    This booklet provides advice on how schools can forge useful working relationships with the news media. Nineteen ground rules for working with print or broadcast media are outlined. The most important rule for all occasions is to make sure that your information is true. Strategies are described for using various tools of the trade, such as the…

  9. Personality, Sex, and Work Values.

    Science.gov (United States)

    Hales, Loyde; Hartman, Timothy

    1978-01-01

    The Vocational Preference Inventory (VPA) and the Ohio Work Values Inventory (OWVI) were administered to 115 undergraduates. A two-factor MANOVA was performed with personality types (VPI) and sex as independent variables and work values (OWVI) as dependent variables. The F-ratios for main effects were significant. (Author/SJL)

  10. Working postures: prediction and evaluation

    NARCIS (Netherlands)

    Delleman, N.J.

    1999-01-01

    To date, workstation designers cannot see the effects of a design on working posture before a mock-up/prototype is available. At that moment, usually the margin for creating the conditions required for adopting favourable working postures is still very limited. Posture prediction at an early design

  11. Counseling for Work and Relationship

    Science.gov (United States)

    Richardson, Mary Sue

    2012-01-01

    Counseling for work and relationship is a social constructionist perspective, informed by feminist and social justice values, and responsive to radical changes in contemporary lives, that fosters a shift in vocational psychology from helping people develop careers to helping people construct lives through work and relationship. The first and major…

  12. Working group report: Quantum chromodynamics

    Indian Academy of Sciences (India)

    The participants of the QCD working sub-group are: Rahul Basu, D Indumathi,. E Laenen, Swapan Majhi, Prakash Mathews, Anuradha Misra, Asmita Mukherjee,. R Ratabole, V Ravindran and W Vogelsang. The main focus of this working group had been to concentrate on some issues in resummation which are essential to ...

  13. Work orientations of female returners

    NARCIS (Netherlands)

    Doorewaard, H.; Hendrickx, J.; Verschuren, P.J.M.

    2004-01-01

    Hakim's Preference Theory on the heterogeneity of the work-life preferences of women, and in particular its implicit assumption that a woman's preference to work or to stay at home is based on her personal choices, has frequently been criticized. Other researchers emphasize the constraining

  14. Working group report: Collider Physics

    Indian Academy of Sciences (India)

    This is summary of the activities of the working group on collider physics in the IXth Workshop on High Energy Physics Phenomenology (WHEPP-9) held at the Institute of Physics, Bhubaneswar, India in January 2006. Some of the work subsequently done on these problems by the subgroups formed during the workshop is ...

  15. Working group report: Neutrino physics

    Indian Academy of Sciences (India)

    Working group report: Neutrino physics. Coordinators: SANDHYA CHOUBEY1,∗ and D INDUMATHI2. Working group members: S Agarwalla1, A Bandyopadhyay1, G Bhattacharyya3,. E J Chun4, B Dasgupta5, A Dighe5, P Ghoshal5, A K Giri6, S Goswami1,. M Hirsch7, T Kajita8, M Kaplinghat9, H S Mani10, R Mohanta11,.

  16. Quantum chromodynamics: Working group report

    Indian Academy of Sciences (India)

    This is the report of the QCD working group at WHEPP-6. Discussions and work on heavy ion collisions, polarized scattering, and collider phenomenology are reported. Keywords. QCD; polarized scattering; light front field theory; heavy ion physics; non-equilibrium field theory; parton distributions at LHC; fragmentation ...

  17. African Journal of Social Work

    African Journals Online (AJOL)

    The African Journal of Social Work is an international refereed journal that serves as a forum for exchanging ideas and knowledge and discussing issues relevant to social work practice, education and research in the African region. Producing 2 issues a year, the Journal is published by the National Association of Social ...

  18. Challenges Facing Group Work Online

    Science.gov (United States)

    Chang, Bo; Kang, Haijun

    2016-01-01

    Online group work can be complicated because of its asynchronous characteristics and lack of physical presence, and its requirements for skills in handling technology, human relationships, and content-related tasks. This study focuses on the administrative, logistical and relationship-related challenges in online group work. Challenges in areas…

  19. Motivational Issues in Knowledge Work

    Directory of Open Access Journals (Sweden)

    Anca BOGDAN

    2008-01-01

    Full Text Available The paper discusses the place of emotions in modern theories of motivation, and the influence of the knowledge-oriented paradigm on redefining motivation and rethinking ways of rendering work, knowledge work, in particular, more efficient, in a society in which human participation and deployment of intellectual capital become key factors of success, replacing traditional, tangible-focused, factors of production.

  20. Social Symbolic Work in Context

    DEFF Research Database (Denmark)

    Brincker, Benedikte

    This paper reports on a research project that explores social symbolic work. The social symbolic work in question seeks to introduce education in entrepreneurship into the school curriculum in a remote part of Greenland – in order to contribute to regional development. The paper investigates how ...... and agility (MMA)....