WorldWideScience

Sample records for wnt-mediated pro-tumourigenic role

  1. Cigarette smoke condensate promotes pro-tumourigenic stromal-epithelial interactions by suppressing miR-145.

    Science.gov (United States)

    Pal, A; Melling, G; Hinsley, E E; Kabir, T D; Colley, H E; Murdoch, C; Lambert, D W

    2013-04-01

    Exposure to factors released from tobacco during chewing or smoking is recognized as a major risk factor for oral carcinogenesis and influences the phenotype of oral epithelial cells and fibroblasts within the underlying stroma. Micro(mi)RNA can regulate the expression of genes within cells, and previous studies show that tobacco products can alter the miRNA profiles in lung epithelial cells. However, the molecular alterations occurring in oral fibroblasts exposed to tobacco constituents remain to be elucidated. Oral fibroblasts were exposed to cigarette smoke condensate (CSC) and miRNA expression compared to untreated controls using tiling low-density arrays (TLDA). Expression of miRNA-145 was confirmed by quantitative (q)RT-PCR. The effect of CSC on fibroblast cell viability, motility and matrix metalloproteinase (MMP)-2 expression was measured using MTS, a wound scratch assay and qRT-PCR, respectively. Oral cancer cell migration in response to culture supernatants from mock, control or pre-miR-145-transfected CSC-treated fibroblasts was analysed by chemotaxis assay. TLDA analysis identified widespread changes in the miRNA expression profile of fibroblasts exposed to CSC. Pri-, pre- and mature miRNA-145 were significantly down-regulated in response to CSC, and this was accompanied by up-regulated expression of MMP-2 and increased migration of fibroblasts compared to untreated controls. Re-expression of miR-145 abrogated the ability of fibroblasts to promote oral cancer cell chemotaxis in response to CSC. These findings suggest that tobacco constituents influence the expression of miRNA within oral fibroblasts promoting a phenotype that increases oral cancer migration and sheds new light on the mechanisms underlying oral cancer pathogenesis. © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  2. The Interplay between Wnt Mediated Expansion and Negative Regulation of Growth Promotes Robust Intestinal Crypt Structure and Homeostasis.

    Directory of Open Access Journals (Sweden)

    Huijing Du

    2015-08-01

    Full Text Available The epithelium of the small intestinal crypt, which has a vital role in protecting the underlying tissue from the harsh intestinal environment, is completely renewed every 4-5 days by a small pool of stem cells at the base of each crypt. How is this renewal controlled and homeostasis maintained, particularly given the rapid nature of this process? Here, based on the recent observations from in vitro "mini gut" studies, we use a hybrid stochastic model of the crypt to investigate how exogenous niche signaling (from Wnt and BMP combines with auto-regulation to promote homeostasis. This model builds on the sub-cellular element method to account for the three-dimensional structure of the crypt, external regulation by Wnt and BMP, internal regulation by Notch signaling, as well as regulation by internally generated diffusible signals. Results show that Paneth cell derived Wnt signals, which have been observed experimentally to sustain crypts in cultured organs, have a dramatically different influence on niche dynamics than does mesenchyme derived Wnt. While this signaling can indeed act as a redundant backup to the exogenous gradient, it introduces a positive feedback that destabilizes the niche and causes its uncontrolled expansion. We find that in this setting, BMP has a critical role in constraining this expansion, consistent with observations that its removal leads to crypt fission. Further results also point to a new hypothesis for the role of Ephrin mediated motility of Paneth cells, specifically that it is required to constrain niche expansion and maintain the crypt's spatial structure. Combined, these provide an alternative view of crypt homeostasis where the niche is in a constant state of expansion and the spatial structure of the crypt arises as a balance between this expansion and the action of various sources of negative regulation that hold it in check.

  3. The Interplay between Wnt Mediated Expansion and Negative Regulation of Growth Promotes Robust Intestinal Crypt Structure and Homeostasis.

    Science.gov (United States)

    Du, Huijing; Nie, Qing; Holmes, William R

    2015-08-01

    The epithelium of the small intestinal crypt, which has a vital role in protecting the underlying tissue from the harsh intestinal environment, is completely renewed every 4-5 days by a small pool of stem cells at the base of each crypt. How is this renewal controlled and homeostasis maintained, particularly given the rapid nature of this process? Here, based on the recent observations from in vitro "mini gut" studies, we use a hybrid stochastic model of the crypt to investigate how exogenous niche signaling (from Wnt and BMP) combines with auto-regulation to promote homeostasis. This model builds on the sub-cellular element method to account for the three-dimensional structure of the crypt, external regulation by Wnt and BMP, internal regulation by Notch signaling, as well as regulation by internally generated diffusible signals. Results show that Paneth cell derived Wnt signals, which have been observed experimentally to sustain crypts in cultured organs, have a dramatically different influence on niche dynamics than does mesenchyme derived Wnt. While this signaling can indeed act as a redundant backup to the exogenous gradient, it introduces a positive feedback that destabilizes the niche and causes its uncontrolled expansion. We find that in this setting, BMP has a critical role in constraining this expansion, consistent with observations that its removal leads to crypt fission. Further results also point to a new hypothesis for the role of Ephrin mediated motility of Paneth cells, specifically that it is required to constrain niche expansion and maintain the crypt's spatial structure. Combined, these provide an alternative view of crypt homeostasis where the niche is in a constant state of expansion and the spatial structure of the crypt arises as a balance between this expansion and the action of various sources of negative regulation that hold it in check.

  4. Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.

    Science.gov (United States)

    Chien, Shih-Chieh Jason; Gurling, Mark; Kim, Changsung; Craft, Teresa; Forrester, Wayne; Garriga, Gian

    2015-08-01

    Wnts are a conserved family of secreted glycoproteins that regulate various developmental processes in metazoans. Three of the five Caenorhabditis elegans Wnts, CWN-1, CWN-2 and EGL-20, and the sole Wnt receptor of the Ror kinase family, CAM-1, are known to regulate the anterior polarization of the mechanosensory neuron ALM. Here we show that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control ALM polarity. We also show that CAM-1 has two functions in this process: an autonomous signaling function that promotes anterior polarization and a nonautonomous Wnt-antagonistic function that inhibits anterior polarization. These antagonistic activities can account for the weak ALM phenotypes displayed by cam-1 mutants. Our observations suggest that CAM-1 could function as a Wnt receptor in many developmental processes, but the analysis of cam-1 mutants may fail to reveal CAM-1's role as a receptor in these processes because of its Wnt-antagonistic activity. In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

    KAUST Repository

    Kay, Sophie K.

    2017-03-01

    The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch’s interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict the likely consequences of biochemical knockouts upon cell fate selection processes. Chemical reaction network theory (CRNT) is a powerful, generalised framework which assesses the capacity of our model for monostability or multistability, by analysing properties of the underlying network structure without recourse to specific parameter values or functional forms for reaction rates. CRNT highlights the role of β-catenin in stabilising the Notch pathway and damping oscillations, demonstrating that Wnt-mediated actions on the Hes1 promoter can induce dynamic transitions in the Notch system, from multistability to monostability. Time-dependent model simulations of cell pairs reveal the stabilising influence of Wnt upon the Notch pathway, in which β-catenin- and Dsh-mediated action on the Hes1 promoter are key in shaping the subcellular dynamics. Where Notch-mediated transcription of Hes1 dominates, there is Notch oscillation and maintenance of fate flexibility; Wnt-mediated transcription of Hes1 favours bistability akin to cell fate selection. Cells could therefore regulate the proportion of Wnt- and Notch-mediated control of the Hes1 promoter to coordinate the timing of cell fate selection as they migrate through the intestinal epithelium and are subject to reduced Wnt stimuli. Furthermore, mutant cells characterised by hyperstimulation of the Wnt pathway may, through coupling with Notch, invert cell fate in neighbouring healthy cells, enabling an aberrant cell to maintain

  6. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

    Directory of Open Access Journals (Sweden)

    Sophie K Kay

    2017-02-01

    Full Text Available The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict the likely consequences of biochemical knockouts upon cell fate selection processes. Chemical reaction network theory (CRNT is a powerful, generalised framework which assesses the capacity of our model for monostability or multistability, by analysing properties of the underlying network structure without recourse to specific parameter values or functional forms for reaction rates. CRNT highlights the role of β-catenin in stabilising the Notch pathway and damping oscillations, demonstrating that Wnt-mediated actions on the Hes1 promoter can induce dynamic transitions in the Notch system, from multistability to monostability. Time-dependent model simulations of cell pairs reveal the stabilising influence of Wnt upon the Notch pathway, in which β-catenin- and Dsh-mediated action on the Hes1 promoter are key in shaping the subcellular dynamics. Where Notch-mediated transcription of Hes1 dominates, there is Notch oscillation and maintenance of fate flexibility; Wnt-mediated transcription of Hes1 favours bistability akin to cell fate selection. Cells could therefore regulate the proportion of Wnt- and Notch-mediated control of the Hes1 promoter to coordinate the timing of cell fate selection as they migrate through the intestinal epithelium and are subject to reduced Wnt stimuli. Furthermore, mutant cells characterised by hyperstimulation of the Wnt pathway may, through coupling with Notch, invert cell fate in neighbouring healthy cells, enabling an aberrant

  7. Roles of Wnt signaling in bone formation and resorption

    Directory of Open Access Journals (Sweden)

    Yasuhiro Kobayashi

    2008-07-01

    Full Text Available Wnt proteins (Wnts are palmitoylated and glycosylated ligands that play a central role in the early development of organs and tissues. The discovery that loss-of-function mutations in low density lipoprotein receptor-related protein 5 (LRP5, a Wnt co-receptor, led to low bone mass in humans revealed the possible role of Wnt signaling in the regulation of bone remodeling. Many findings obtained from detailed analyses of mice having mutations of Wnt signaling molecules have confirmed that Wnt signaling has potential roles in bone remodeling in both physiological and pathological conditions. There are two pathways of Wnt signaling: β-catenin-dependent canonical and -independent non-canonical pathways. Wnts act on osteoblast precursor cells and promote their differentiation into mature osteoblasts through the β-catenin-dependent canonical pathway. In addition, Wnts suppress bone resorption by regulating the receptor activator of NF-κB ligand (RANKL/osteoprotegerin (OPG ratio through the same pathway in mature osteoblasts. In contrast, recent studies have shown that the activation of the β-catenin-independent non-canonical pathway enhances the RANKL-induced osteoclast formation in mouse macrophage cultures. These results indicate that Wnt-mediated signals are involved in several aspects of bone formation and bone resorption. This review will summarize the current knowledge of the roles of Wnt signaling in bone formation and resorption.

  8. ROS signalling in the biology of cancer.

    Science.gov (United States)

    Moloney, Jennifer N; Cotter, Thomas G

    2017-06-03

    Increased reactive oxygen species (ROS) production has been detected in various cancers and has been shown to have several roles, for example, they can activate pro-tumourigenic signalling, enhance cell survival and proliferation, and drive DNA damage and genetic instability. Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour cells express elevated levels of antioxidant proteins to detoxify elevated ROS levels, establish a redox balance, while maintaining pro-tumourigenic signalling and resistance to apoptosis. Tumour cells have an altered redox balance to that of their normal counterparts and this identifies ROS manipulation as a potential target for cancer therapies. This review discusses the generation and sources of ROS within tumour cells, the regulation of ROS by antioxidant defence systems, as well as the effect of elevated ROS production on their signalling targets in cancer. It also provides an insight into how pro- and anti-tumourigenic ROS signalling pathways could be manipulated in the treatment of cancer. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. The receptor RAGE: Bridging inflammation and cancer

    Directory of Open Access Journals (Sweden)

    Hess Jochen

    2009-05-01

    Full Text Available Abstract The receptor for advanced glycation end products (RAGE is a single transmembrane receptor of the immunoglobulin superfamily that is mainly expressed on immune cells, neurons, activated endothelial and vascular smooth muscle cells, bone forming cells, and a variety of cancer cells. RAGE is a multifunctional receptor that binds a broad repertoire of ligands and mediates responses to cell damage and stress conditions. It activates programs responsible for acute and chronic inflammation, and is implicated in a number of pathological diseases, including diabetic complications, stroke, atheriosclerosis, arthritis, and neurodegenerative disorders. The availability of Rage knockout mice has not only advanced our knowledge on signalling pathways within these pathophysiological conditions, but also on the functional importance of the receptor in processes of cancer. Here, we will summarize molecular mechanisms through which RAGE signalling contributes to the establishment of a pro-tumourigenic microenvironment. Moreover, we will review recent findings that provide genetic evidence for an important role of RAGE in bridging inflammation and cancer.

  10. Resistance of R-Ras knockout mice to skin tumour induction

    Science.gov (United States)

    May, Ulrike; Prince, Stuart; Vähätupa, Maria; Laitinen, Anni M.; Nieminen, Katriina; Uusitalo-Järvinen, Hannele; Järvinen, Tero A. H.

    2015-01-01

    The R-ras gene encodes a small GTPase that is a member of the Ras family. Despite close sequence similarities, R-Ras is functionally distinct from the prototypic Ras proteins; no transformative activity and no activating mutations of R-Ras in human malignancies have been reported for it. R-Ras activity appears inhibitory towards tumour proliferation and invasion, and to promote cellular quiescence. Contrary to this, using mice with a deletion of the R-ras gene, we found that R-Ras facilitates DMBA/TPA-induced skin tumour induction. The tumours appeared in wild-type (WT) mice on average 6 weeks earlier than in R-Ras knockout (R-Ras KO) mice. WT mice developed almost 6 times more tumours than R-Ras KO mice. Despite strong R-Ras protein expression in the dermal blood vessels, no R-Ras could be detected in the epidermis from where the tumours arose. The DMBA/TPA skin tumourigenesis-model is highly dependent upon inflammation, and we found a greatly attenuated skin inflammatory response to DMBA/TPA-treatment in the R-Ras KO mice in the context of leukocyte infiltration and proinflammatory cytokine expression. Thus, these data suggest that despite its characterised role in promoting cellular quiescence, R-Ras is pro-tumourigenic in the DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment. PMID:26133397

  11. The complement system in cancer: Ambivalence between tumour destruction and promotion.

    Science.gov (United States)

    Mamidi, Srinivas; Höne, Simon; Kirschfink, Michael

    2017-01-01

    Constituting a part of the innate immune system, the complement system consists of over 50 proteins either acting as part of a 3-branch activation cascade, a well-differentiated regulatory system in fluid phase or on each tissue, or as receptors translating the activation signal to multiple cellular effector functions. Complement serves as first line of defence against infections from bacteria, viruses and parasites by orchestrating the immune response through opsonisation, recruitment of immune cells to the site of infection and direct cell lysis. Complement is generally recognised as a protective mechanism against the formation of tumours in humans, but is often limited by various resistance mechanisms interfering with its cytotoxic action, now considered as a great barrier of successful antibody-based immunotherapy. However, recent studies also indicate a pro-tumourigenic potential of complement in certain cancers and under certain conditions. In this review, we present recent findings on the possible dual role of complement in destroying cancer, especially if resistance mechanisms are blocked, but also under certain inflammatory conditions-promoting tumour development. Copyright © 2015 Elsevier GmbH. All rights reserved.

  12. ASPM regulates Wnt signaling pathway activity in the developing brain.

    Science.gov (United States)

    Buchman, Joshua J; Durak, Omer; Tsai, Li-Huei

    2011-09-15

    Autosomal recessive primary microcephaly (MCPH) is a neural developmental disorder in which patients display significantly reduced brain size. Mutations in Abnormal Spindle Microcephaly (ASPM) are the most common cause of MCPH. Here, we investigate the underlying functions of Aspm in brain development and find that Aspm expression is critical for proper neurogenesis and neuronal migration. The Wnt signaling pathway is known for its roles in embryogenesis, and genome-wide siRNA screens indicate that ASPM is a positive regulator of Wnt signaling. We demonstrate that knockdown of Aspm results in decreased Wnt-mediated transcription, and that expression of stabilized β-catenin can rescue this deficit. Finally, coexpression of stabilized β-catenin can rescue defects observed upon in vivo knockdown of Aspm. Our findings provide an impetus to further explore Aspm's role in facilitating Wnt-mediated neurogenesis programs, which may contribute to psychiatric illness etiology when perturbed.

  13. A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.

    Science.gov (United States)

    Terriente-Félix, Ana; Pérez, Lidia; Bray, Sarah J; Nebreda, Angel R; Milán, Marco

    2017-04-01

    Myeloproliferative neoplasms (MPNs) of the Philadelphia-negative class comprise polycythaemia vera, essential thrombocythaemia and primary myelofibrosis (PMF). They are associated with aberrant numbers of myeloid lineage cells in the blood, and in the case of overt PMF, with development of myelofibrosis in the bone marrow and failure to produce normal blood cells. These diseases are usually caused by gain-of-function mutations in the kinase JAK2. Here, we use Drosophila to investigate the consequences of activation of the JAK2 orthologue in haematopoiesis. We have identified maturing haemocytes in the lymph gland, the major haematopoietic organ in the fly, as the cell population susceptible to induce hypertrophy upon targeted overexpression of JAK. We show that JAK activates a feed-forward loop, including the cytokine-like ligand Upd3 and its receptor, Domeless, which are required to induce lymph gland hypertrophy. Moreover, we present evidence that p38 MAPK signalling plays a key role in this process by inducing expression of the ligand Upd3. Interestingly, we also show that forced activation of the p38 MAPK pathway in maturing haemocytes suffices to generate hypertrophic organs and the appearance of melanotic tumours. Our results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of MPNs. Based on the shared molecular mechanisms underlying MPNs in flies and humans, the interplay between Drosophila JAK and p38 signalling pathways unravelled in this work might have translational relevance for human MPNs. © 2017. Published by The Company of Biologists Ltd.

  14. Entrepreneurship and Role Models

    NARCIS (Netherlands)

    N. Bosma (Niels); S.J.A. Hessels (Jolanda); V. Schutjens (Veronique); M. van Praag (Mirjam); I. Verheul (Ingrid)

    2011-01-01

    textabstractIn the media role models are increasingly being acknowledged as an influential factor in explaining the reasons for the choice of occupation and career. Various conceptual studies have proposed links between role models and entrepreneurial intentions. However, empirical research aimed at

  15. Semantic Role Labeling

    CERN Document Server

    Palmer, Martha; Xue, Nianwen

    2011-01-01

    This book is aimed at providing an overview of several aspects of semantic role labeling. Chapter 1 begins with linguistic background on the definition of semantic roles and the controversies surrounding them. Chapter 2 describes how the theories have led to structured lexicons such as FrameNet, VerbNet and the PropBank Frame Files that in turn provide the basis for large scale semantic annotation of corpora. This data has facilitated the development of automatic semantic role labeling systems based on supervised machine learning techniques. Chapter 3 presents the general principles of applyin

  16. Roles within the Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  17. Role-Playing Mitosis.

    Science.gov (United States)

    Wyn, Mark A.; Stegink, Steven J.

    2000-01-01

    Introduces a role playing activity that actively engages students in the learning process of mitosis. Students play either chromosomes carrying information, or cells in the cell membrane. (Contains 11 references.) (Author/YDS)

  18. Teachers' interpersonal role identity

    NARCIS (Netherlands)

    van der Want, Anna C.; den Brok, Perry; Beijaard, Douwe; Brekelmans, Mieke; Claessens, Luce C A; Pennings, Helena J M

    2014-01-01

    This article investigates the link between teachers' appraisal of specific interpersonal situations in classrooms and their more general interpersonal identity standard, which together form their interpersonal role identity. Using semi-structured and video-stimulated interviews, data on teachers'

  19. Teachers' Interpersonal Role Identity

    NARCIS (Netherlands)

    van der Want, Anna C.; den Brok, Perry; Beijaard, Douwe; Brekelmans, Mieke; Claessens, Luce C A; Pennings, Helena J M

    2015-01-01

    This article investigates the link between teachers' appraisal of specific interpersonal situations in classrooms and their more general interpersonal identity standard, which together form their interpersonal role identity. Using semi-structured and video-stimulated interviews, data on teachers'

  20. Reviewing Roles and Responsibilities.

    Science.gov (United States)

    Hull, Howard; Robertson, John

    1981-01-01

    Outlines the roles of the following groups in creating and maintaining a quality school art program: superintendents and boards of education, principals, parent teacher organizations, state art supervisors, classroom teachers, local art supervisors, and certified art specialists. (SJL)

  1. Human Resource Management Roles

    OpenAIRE

    Tamara R. Mitchell

    2017-01-01

    The roles of Human Resource and Management play a vital role in the success of the organization. Internal recruitment is more valuable than external recruitment because it is less expensive, the employee’s skills are well known and companies that do internal recruitment have an important tool to boost morale in the organization. Performance management is an important part of an organization. The most important thing is that it strengthens the supervisor and employee relationship and promotes ...

  2. Teacher roles in Learning Games

    DEFF Research Database (Denmark)

    Magnussen, Rikke

    2007-01-01

    the roles as forensic experts who solve a series of murder cases. When teachers use this type of games, they have to adapt to new teaching situations and roles. This includes the fictional role in a game, but also the role as a supervisor for a group of students that play the role as professional experts. I...

  3. Gender roles revised?

    DEFF Research Database (Denmark)

    Gustafsson, Jessica

    2018-01-01

    the basis for this chapter is set in Kenya, where family relations and gender roles is presently undergoing changes. The data was gathered in Uasin Gishu County, Kenya, an area, which is predominantly rural, but also home to the city Eldoret and its surrounding peri-urban areas. The situation for women...... phones be understood in relation to, and inform us about changing gender relations in contemporary Kenya? The chapter demonstrates that on the one hand, distinctive gendered usage of mobile phones is present - practices that are direct consequences of prevailing gender roles. On the other hand...... in many relationships and marriages. The phenomenon of mpango wa kando and how women relate and deal with it, is interesting from a gender point of view, as it highlights the tension between traditional and modern culture and is therefore an interesting departure to discuss whether and how gender roles...

  4. Role of the Physician Anesthesiologist

    Science.gov (United States)

    ... Team Physician Anesthesiologist Role of the Physician Anesthesiologist Role of the Physician Anesthesiologist When preparing for surgery, ... points and beyond. Physician anesthesiologists play a vital role in a patient’s medical care, making decisions to ...

  5. Adults Role in Bullying

    Science.gov (United States)

    Notar, Charles E.; Padgett, Sharon

    2013-01-01

    Do adults play a role in bullying? Do parents, teachers, school staff, and community adult leaders influence bullying behavior in children and teenagers? This article will focus on research regarding all adults who have almost daily contact with children and teens and their part in how bullying is identified, addressed, and prevented. This article…

  6. Teachers' Interpersonal Role Identity

    Science.gov (United States)

    van der Want, Anna C.; den Brok, Perry; Beijaard, Douwe; Brekelmans, Mieke; Claessens, Luce C. A.; Pennings, Helena J. M.

    2015-01-01

    This article investigates the link between teachers' appraisal of specific interpersonal situations in classrooms and their more general interpersonal identity standard, which together form their interpersonal role identity. Using semi-structured and video-stimulated interviews, data on teachers' appraisals and interpersonal identity standards…

  7. Role of assessment

    African Journals Online (AJOL)

    User

    students' learning. In the section, assessment as a means of curriculum operation and experience in everyday classroom context is also discussed. Moreover, the section focuses on roles of course instructor in integrating assessment with everyday classroom instruction, and in facilitating appropriate learning environments.

  8. Tribbles role in reproduction.

    Science.gov (United States)

    Basatvat, Shaghayegh; Carter, Deborah Angela Louise; Kiss-Toth, Endre; Fazeli, Alireza

    2015-10-01

    Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events. © 2015 Authors; published by Portland Press Limited.

  9. Strategic Roles of Manufacturing

    DEFF Research Database (Denmark)

    Yang, Cheng

    Addressing three development trends of manufacturing, this thesis aims to explore: (1) facing challenges on manufacturing (globalisation, knowledge-based manufacturing and servitisation of manufacturing), what kinds of roles does manufacturing play within industrial companies; (2) along...... with the trend of globalisation, how do industrial companies develop their global manufacturing networks? These two questions are actually interlinked. On the one hand, facing increasing offshoring and outsourcing of production activities, industrial companies have to understand how to develop their global...... manufacturing networks. On the other hand, ongoing globalisation also brings tremendous impacts to post-industrial economies (e.g. Denmark). A dilemma therefore arises, i.e. whether it is still necessary to keep manufacturing in these post-industrial economies; if yes, what kinds of roles manufacturing should...

  10. Microorganisms (Microbes), Role of

    DEFF Research Database (Denmark)

    Fenchel, Tom

    2013-01-01

    Microorganisms (microbes) are those life forms too small to be seen by the naked eye; that is, those that require a microscope or other form of magnification in order to be observed. The term microorganism is thus a functional description rather than a taxonomic one, and the grouping includes...... a wide variety of organisms. The article focuses on the functional role of microbes in the biosphere and in different types of habitats - especially in terms of flow of energy and matter....

  11. The motivational theory of role modeling : How role models influence role aspirants' goals

    NARCIS (Netherlands)

    Morgenroth, Thekla; Ryan, Michelle K.; Peters, Kim

    2015-01-01

    Role models are often suggested as a way of motivating individuals to set and achieve ambitious goals, especially for members of stigmatized groups in achievement settings. Yet, the literature on role models tends not to draw on the motivational literature to explain how role models may help role

  12. Categorizing entities by common role.

    Science.gov (United States)

    Goldwater, Micah B; Markman, Arthur B

    2011-04-01

    Many categories group together entities that play a common role across situations. For example, guest and host refer to complementary roles in visiting situations and, thus, are role-governed categories (A. B. Markman & Stilwell, Journal of Experiment & Theoretical Artificial Intelligence, 13, 329-358, 2001). However, categorizing an entity by role is one of many possible classification strategies. This article examines factors that promote role-governed categorization over thematic-relation-based categorization (Lin & Murphy, Journal of Experimental Psychology: General, 130, 3-28, 2001). In Experiments 1a and 1b, we demonstrate that the use of novel category labels facilitates role-governed categorization. In Experiments 2a and 2b, we demonstrate that analogical comparison facilitates role-governed categorization. In Experiments 1b and 2b, we show that these facilitatory factors induce a general sensitivity to role information, as opposed to only promoting role-governed categorization on an item-by-item basis.

  13. Roles and Role Conflict of Women in Infertile Couples.

    Science.gov (United States)

    Allison, Janet R.

    1979-01-01

    Explores the experience of role conflict for women in infertile couples. Findings lead to an understanding of infertility as part of an interactional system for dealing with potentially intolerable sources of role conflict. (Author)

  14. Role Models on Dope

    DEFF Research Database (Denmark)

    Christiansen, Ask Vest; Gleaves, John

    2014-01-01

    Compared to football-players cyclists are virtuous role models. Yes, Lance Armstrong, Michael Rasmussen and other riders have doped, and because of this they have received the predicate as the most immoral athletes in the sporting world. But if morality is not only a question of whether a person...... has enhanced his or hers performances by the use of various drugs (and lied about it), but also is about human beings’ relations and interactions, then cycling isn’t as depraved as we like to tell each other. Football is much worse....

  15. Congruency between role perception and role performance of ...

    African Journals Online (AJOL)

    A study was conducted to ascertain the level of congruency between extension agents' role perception and role performance with a view to providing policy makers and extension practitioners with better understanding of the role inconsistencies that are contributing to the ineffectiveness of extension agents and in ...

  16. Perceived Role Achievement and Role Expectation of Local ...

    African Journals Online (AJOL)

    Questionnaire and interview schedule were used to collect data on agricultural role expectation and role achievement of LGAs from 179 LG staff members and 145 farmers using multistage sampling. Data were analysed using mean score, standard deviation and students' t-test. The mean scores for farmers on role ...

  17. Neuroendocrine Role for VGF

    Directory of Open Access Journals (Sweden)

    Jo Edward Lewis

    2015-02-01

    Full Text Available The vgf gene (non-acronymic is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain derived neurotrophic factor, and glial derived growth factor. The VGF gene gives rise to a 68kDa precursor polypeptide which is induced robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific pro-hormone convertases in these cells results in the production of a number of smaller peptides. The VGF gene and peptides are widely expressed throughout the brain, particularly the hypothalamus and hippocampus, and in peripheral tissues including the pituitary gland, the adrenal glands and the pancreas, and in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. VGF peptides have been associated with a number of neuroendocrine roles and in this mini-review we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction and cognition.

  18. CULTURE AND GENDER ROLE DIFFERENCES

    National Research Council Canada - National Science Library

    Angelica-Nicoleta NECULĂESEI (ONEA)

    2015-01-01

    .... The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers...

  19. Roles in Innovative Software Teams

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2010-01-01

    With inspiration from role-play and improvisational theater, we are developing a framework for innovation in software teams called Essence. Based on agile principles, Essence is designed for teams of developers and an onsite customer. This paper reports from teaching experiments inspired by design...... science, where we tried to assign differentiated roles to team members. The experiments provided valuable insights into the design of roles in Essence. These insights are used for redesigning how roles are described and conveyed in Essence....

  20. Role Play in Language Learning.

    Science.gov (United States)

    Livingstone, Carol

    A guide to the use of role playing in the foreign language classroom outlines in general terms what role play is, provides examples, analyzes its uses, and gives practical assistance in planning activities. The following topics are examined: aspects of role behavior (formality, register, function, attitude, para-linguistic and extra-linguistic…

  1. Nutritional role of folate.

    Science.gov (United States)

    Ebara, Shuhei

    2017-09-01

    Folate functions as a coenzyme to transfer one-carbon units that are necessary for deoxythymidylate synthesis, purine synthesis, and various methylation reactions. Ingested folate becomes a functional molecule through intestinal absorption, circulation, transport to cells, and various modifications to its structure. Associations between nutritional folate status and chronic diseases such as cardiovascular disease, cancer, and cognitive dysfunction have been reported. It has also been reported that maternal folate nutritional status is related to the risk of neural tube defects (NTDs) in the offspring. It has also been recommended that folate be consumed in the diet to promote the maintenance of good health. To reduce the risk of NTDs, supplementation with folic acid (a synthetic form of folate) during the periconceptional period has also been recommended. This paper describes the basic features and nutritional role of folate. © 2017 Japanese Teratology Society.

  2. Climate's Role in Terroir

    Science.gov (United States)

    Jones, G. V.

    2012-12-01

    The marriage between a given winegrape cultivar planted in its ideal climate, over favorable topography and physical soil characteristics, combine to create the potential to produce fine wine. The French term terroir embodies this potential as a holistic concept that relates to both environmental and cultural factors that together influence the grape growing to wine production continuum. While the landscape, geology, soil, and climate strongly interact to influence the vine's balance of nutrients and water, climate is clearly of prevailing importance in that it limits where grapes can be grown at both the global and site scale. This talk will review the nature of climate's role in terroir through a discussion of the structure of climate in wine regions globally and how this structure influences cultivar suitability. Furthermore, the talk will use two of the most commonly planted red wine cultivars as examples - Pinot Noir and Cabernet Sauvignon - providing details on the historic, current, and future climate structure of wine regions growing these cultivars. In general the examination reveals that cool climate cultivars tend to have a narrower climate niche for high quality wine production, than do warmer climate cultivars, with less range of adaptation. Furthermore, the range of the climate suitability of these two cultivars shows that potentially new terroirs for each are waiting to be found.

  3. Novel roles of gastrin.

    Science.gov (United States)

    Dimaline, Rod; Varro, Andrea

    2014-07-15

    The existence of the hormone gastrin in the distal stomach (antrum) has been known for almost 110 years, and the physiological function of this amidated peptide in regulating gastric acid secretion via the CCK2 receptor is now well established. In this brief review we consider important additional roles of gastrin, including regulation of genes encoding proteins such as plasminogen activator inhibitors and matrix metalloproteinases that have important actions on extracellular matrix remodelling. These actions are, at least in part, effected by paracrine signalling pathways and make important contributions to maintaining functional integrity of the gastric epithelium. Recent studies also provide support for the idea that gastrin, in concert with other hormones, could potentially contribute a post-prandial incretin effect. We also review recent developments in the biology of other gastrin gene products, including the precursor progastrin, which causes proliferation of the colonic epithelium and in certain circumstances may induce cancer formation. Glycine-extended biosynthetic processing intermediates also have proliferative effects in colonic mucosa and in some oesophageal cancer cell lines. Whether these additional gene products exert their effects through the CCK2 receptor or a separate entity is currently a matter of debate. © 2014 The Authors. The Journal of Physiology © 2014 The Physiological Society.

  4. Novel roles of gastrin

    Science.gov (United States)

    Dimaline, Rod; Varro, Andrea

    2014-01-01

    The existence of the hormone gastrin in the distal stomach (antrum) has been known for almost 110 years, and the physiological function of this amidated peptide in regulating gastric acid secretion via the CCK2 receptor is now well established. In this brief review we consider important additional roles of gastrin, including regulation of genes encoding proteins such as plasminogen activator inhibitors and matrix metalloproteinases that have important actions on extracellular matrix remodelling. These actions are, at least in part, effected by paracrine signalling pathways and make important contributions to maintaining functional integrity of the gastric epithelium. Recent studies also provide support for the idea that gastrin, in concert with other hormones, could potentially contribute a post-prandial incretin effect. We also review recent developments in the biology of other gastrin gene products, including the precursor progastrin, which causes proliferation of the colonic epithelium and in certain circumstances may induce cancer formation. Glycine-extended biosynthetic processing intermediates also have proliferative effects in colonic mucosa and in some oesophageal cancer cell lines. Whether these additional gene products exert their effects through the CCK2 receptor or a separate entity is currently a matter of debate. PMID:24665102

  5. Role Engagement and Anonymity in Synchronous Online Role Play

    Directory of Open Access Journals (Sweden)

    Sarah Cornelius

    2011-06-01

    Full Text Available Role play activities provide opportunities for learners to adopt unfamiliar roles, engage in interactions with others, and get involved in realistic tasks. They are often recommended to foster the development of soft skills and a wider perspective of the world. Such activities are widely used as an online teaching approach, with examples ranging from the simple use of email to the employment of virtual worlds and Web 2.0 technologies.This paper provides a case study of a role play activity which employs real-time anonymous discussion forums and aims to improve our understanding of effective role play and the impact of anonymity. This role play has been effective in educating learners about different perspectives on the issue of Quality in Further Education. The context and implementation of the role play are outlined, and the learners’ interactions and experiences are explored using an investigative analysis of discussion transcripts and semi-structured interviews with participants. The findings suggest that role engagement and anonymity are important components for success in synchronous online role play. Evidence is presented that provides an insight into the factors which encourage role engagement, including prior experiences and contributions from peers. The impact of anonymity is also explored since many participants did not regard the study environment as real and attempted to identify their peers.

  6. Role model and prototype matching

    DEFF Research Database (Denmark)

    Lykkegaard, Eva; Ulriksen, Lars

    2016-01-01

    Previous research has found that young people’s prototypes of science students and scientists affect their inclination to choose tertiary STEM programs (Science, Technology, Engineering and Mathematics). Consequently, many recruitment initiatives include role models to challenge these prototypes......’ meetings with the role models affected their thoughts concerning STEM students and attending university. The regular self-to-prototype matching process was shown in real-life role-models meetings to be extended to a more complex three-way matching process between students’ self-perceptions, prototype...... images and situation-specific conceptions of role models. Furthermore, the study underlined the positive effect of prolonged role-model contact, the importance of using several role models and that traditional school subjects catered more resistant prototype images than unfamiliar ones did...

  7. A Critical Role for Role-Playing Pedagogy

    Science.gov (United States)

    Shapiro, Shawna; Leopold, Lisa

    2012-01-01

    This article draws from practitioners' experience and from scholarship in a variety of disciplines to construct a rationale for incorporating what we call "critical role-play" in the English-for-academic-purposes (EAP) classroom. We discuss the historical significance of role-play in TESOL and explore why this type of pedagogy has become less…

  8. Role Engagement and Anonymity in Synchronous Online Role Play

    Science.gov (United States)

    Cornelius, Sarah; Gordon, Carole; Harris, Margaret

    2011-01-01

    Role play activities provide opportunities for learners to adopt unfamiliar roles, engage in interactions with others, and get involved in realistic tasks. They are often recommended to foster the development of soft skills and a wider perspective of the world. Such activities are widely used as an online teaching approach, with examples ranging…

  9. Role ambiguity, role conflict and work overload and their influence ...

    African Journals Online (AJOL)

    For some educators who assume the dual role of teaching in the classroom and taking on a further role of sport facilitator within a school environment can become highly emotional. The potential for stress is high since they have to work with class sizes of 40 and more learners for long periods of time and at the same time ...

  10. Perceived Role Achievement and Role Expectation of Local ...

    African Journals Online (AJOL)

    USER

    Food and Agricultural Organization (FAO) ... on agricultural role expectation and role achievement of LGAs from 179 LG staff members and 145 farmers ... maintenance and regulation of slaughter houses, slaughter slab, markets, market gardens ..... sector. A paper presented at a 3-day workshop for Agricultural Officers.

  11. The role of incentives in nurses' aspirations to management roles.

    Science.gov (United States)

    Wong, Carol A; Spence Laschinger, Heather K; Cziraki, Karen

    2014-06-01

    The objective of this study was to describe findings from a study examining nurses' perceptions of incentives for pursuing management roles. Upcoming retirements of nurse managers and a reported lack of interest in manager roles signal concerns about a leadership shortage. However, there is limited research on nurses' career aspirations and specifically the effect of perceived incentives for pursuing manager roles. Data from a national, cross-sectional survey of Canadian nurses were analyzed (n = 1241) using multiple regression to measure the effect of incentives on nurses' career aspirations. Twenty-four percent of nurses expressed interest in pursuing management roles. Age, education, and incentives explained 43% of the variance in career aspirations. Intrinsically oriented incentives such as new challenges, autonomy, and the opportunity to influence others were the strongest predictors of aspirations to management roles. Ensuring an adequate supply of nurse managers will require proactive investment in the identification, recruitment, and development of nurses with leadership potential.

  12. Roles of Communication Problems and Communication Strategies on Resident-Related Role Demand and Role Satisfaction.

    Science.gov (United States)

    Savundranayagam, Marie Y; Lee, Christopher

    2017-03-01

    This study investigated the impact of dementia-related communication difficulties and communication strategies used by staff on resident-related indicators of role demand and role satisfaction. Formal/paid long-term care staff caregivers (N = 109) of residents with dementia completed questionnaires on dementia-related communication difficulties, communication strategies, role demand (ie, residents make unreasonable demands), and role satisfaction (measured by relationship closeness and influence over residents). Three types of communication strategies were included: (a) effective repair strategies, (b) completing actions by oneself, and (c) tuning out or ignoring the resident. Analyses using structural equation modeling revealed that communication problems were positively linked with role demand. Repair strategies were positively linked with relationship closeness and influence over residents. Completing actions by oneself was positively linked to role demand and influence over residents, whereas tuning out was negatively linked with influence over residents. The findings underscore that effective caregiver communication skills are essential in enhancing staff-resident relationships.

  13. Role-Oriented Enterprise Systems

    DEFF Research Database (Denmark)

    Holst, Philip; Beringer, Joerg; Winther, Jacob

    This paper examines the concept of role-­oriented enterprise systems by investigating motivations for and approaches to constructing and reflecting predefined organizational roles in user interfaces of packaged enterprise systems. The research is conducted as case studies of Microsoft and SAP...

  14. Understanding medical practice team roles.

    Science.gov (United States)

    Hills, Laura

    2015-01-01

    Do you believe that the roles your employees play on your medical practice team are identical to their job titles or job descriptions? Do you believe that team roles are determined by personality type? This article suggests that a more effective way to build and manage your medical practice team is to define team roles through employee behaviors. It provides 10 rules of behavioral team roles that can help practice managers to select and build high-performing teams, build more productive team relationships, improve the employee recruitment process, build greater team trust and understanding; and increase their own effectiveness. This article describes in detail Belbin's highly regarded and widely used team role theory and summarizes four additional behavioral team role theories and systems. It offers lessons learned when applying team role theory to practice. Finally, this article offers an easy-to-implement method for assessing current team roles. It provides a simple four-question checklist that will help practice managers balance an imbalanced medical practice team.

  15. Restructuring the Assistant Principal's Role.

    Science.gov (United States)

    Williams, Fredonia B.

    1995-01-01

    Assistant principals should be expected, encouraged, and empowered to work beyond their disciplines, outside their cultures, and above their traditional roles. The assistant principal's role in team management is to become an advocate for excellence, a visionary leader, a change agent, a communicator, a motivator, and a determinant of school…

  16. Union Roles in Workplace Literacy.

    Science.gov (United States)

    Hensley, Stephen Michael

    1993-01-01

    Discusses roles for labor unions in resolving workforce deficiencies, suggesting that labor, management, and government must work together to develop cooperative training initiatives. Describes labor's historic role in basic and workplace literacy training, lists skills workers need in the "new" workplace, describes exemplary union-management…

  17. Role clarity and role conflict among Swedish diabetes specialist nurses.

    Science.gov (United States)

    Boström, Eva; Hörnsten, Asa; Lundman, Berit; Stenlund, Hans; Isaksson, Ulf

    2013-10-01

    To explore diabetes specialist nurses (DSNs)' perceptions of their role in terms of clarity, conflict and other psychosocial work aspects. A cross-sectional study was conducted among DSNs in a county in northern Sweden. The DSNs answered the Nordic Questionnaire of Psychological and Social Factors at Work (QPS Nordic) about psychosocial aspects of their work. Statistical analysis compared DSNs with a reference group of different health professionals. Correlations between role clarity, role conflict, and other variables were analysed. The DSNs perceived more, and higher, job demands, including quantitative, decision-making and learning demands, but also more positive challenges at work compared with the reference group. Role clarity correlated with experiences of health promotion, perception of mastery, co-worker support, and empowering leadership, while role conflict correlated with quantitative and learning demands. The DSNs perceived high demands but also positive challenges in their work. Their role expectations correlated with several psychosocial work aspects. It is important that DSNs should be presented with positive challenges as meaningful incentives for further role development and enhanced mastery of their work. Copyright © 2013 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  18. The Nephrology Clinical Research Nurse Role: Potential Role Conflicts.

    Science.gov (United States)

    Micklos, Lisa

    2016-01-01

    Clinical research nursing is becoming more visible to nephrology professionals. As more nephrology practices and units are participating in clinical trials, clinical research nursing is gaining interest as a career niche among nephrology nurses. This unique specialty requires that nephrology clinical nurse nurses (CRNs) reconcile the roles of nurse as caregiver and nurse as researcher, which may result in a role conflict. Nephrology nurses should be aware that they may experience this role conflict when transitioning from patient care to a position as a clinical research nurse. These nurses can rely on the American Nurses Association's Code of Ethics for Nurses and the Oncology Nursing Society's Oncology Clinical Trials Nurse Competencies to help reconcile the potential role conflict.

  19. New strategic roles of manufacturing

    DEFF Research Database (Denmark)

    Yang, Cheng; Johansen, John; Boer, Harry

    2008-01-01

    This paper aims to view manufacturing from a new angle, and tries to look beyond fit, focus and trade-offs, approaches which may no longer be sufficient for long-term competitive success. Four cases from different industries are described and used to illustrate and discuss the possibility...... of manufacturing playing new strategic roles. Backward, forward and lateral interactive support are suggested to explicate how manufacturing can realize its new strategic roles. Finally, four new strategic roles of manufacturing are suggested. They are: innovation manufacturing, ramp-up manufacturing, primary...... manufacturing, and service manufacturing....

  20. CULTURE AND GENDER ROLE DIFFERENCES

    Directory of Open Access Journals (Sweden)

    Angelica-Nicoleta NECULĂESEI (ONEA

    2015-06-01

    Full Text Available Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation of these issues from the interdisciplinary perspective is the subject of this article. Briefly, the article refers to: importance of communication in transmission of roles of those two sexes, cultural dimensions that reflect role differences invarious cultures, discrimination issues and ethics of sexual difference.

  1. Occupational Therapy's Role with Autism

    Science.gov (United States)

    Fact Sheet Occupational Therapy’s Role with Autism Autism is a developmental disorder—typically diagnosed around age 3 years— that affects brain functions, specifically those areas that control social behaviors ...

  2. [The changing role of physicians].

    Science.gov (United States)

    Siegrist, J

    2012-09-01

    Despite a very successful process of professionalisation during the past 150 years, today's physicians face several challenges urging them to adapt their traditional professional role and the patient-physician relationship inherent in this role. Among these challenges, a growing economic influence on physicians' practices, new demands from particular groups of patients (consumerism, role of the Internet etc.), and increasing inter-professional competition deserve special attention. New evidence of an association between a stressful work environment and physician's increased health risks provides additional support in favour of this notion. This contribution suggests potential directions of change of the physician's role by pointing to (a) a growing 'feminisation' of medicine, (b) an even stronger emphasis on patient needs and (c) extended teamwork and inter-professional cooperation.

  3. The Emerging Roles of Thyroglobulin

    Directory of Open Access Journals (Sweden)

    Yuqian Luo

    2014-01-01

    Full Text Available Thyroglobulin (Tg, the most important and abundant protein in thyroid follicles, is well known for its essential role in thyroid hormone synthesis. In addition to its conventional role as the precursor of thyroid hormones, we have uncovered a novel function of Tg as an endogenous regulator of follicular function over the past decade. The newly discovered negative feedback effect of Tg on follicular function observed in the rat and human thyroid provides an alternative explanation for the observation of follicle heterogeneity. Given the essential role of the regulatory effects of Tg, we consider that dysregulation of normal Tg function is associated with multiple human thyroid diseases including autoimmune thyroid disease and thyroid cancer. Additionally, extrathyroid Tg may serve a regulatory function in other organs. Further exploration of Tg action, especially at the molecular level, is needed to obtain a better understanding of both the physiological and pathological roles of Tg.

  4. Team Effectiveness and Leadership Roles

    OpenAIRE

    Duygulu, Ethem; Ciraklar, Nurcan

    2008-01-01

    In this study we aim to explain the patterns of leadership roles for team effectiveness in non economic organizations compared to economic organizations. For this purpose, we studied three successful organization types, i.e the amateur sports clubs (football, basketball), theater companies and, regional folk groups. Our basic hypothesis is that the relationship between the type of organization (specially teams) and the role of leadership is not random. Therefore, we believe that a...

  5. CULTURE AND GENDER ROLE DIFFERENCES

    OpenAIRE

    Angelica-Nicoleta NECULĂESEI (ONEA)

    2015-01-01

    Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation...

  6. The roles of viruses in periodontal diseases

    OpenAIRE

    C C Azodo; P Erhabor

    2015-01-01

    The roles of bacteria in the etiopathogenesis of periodontal disease are well-understand, but that of the virus found in the periodontal environment are poorly understood. The aim of this literature review was to report the roles of viruses in periodontal diseases. The roles of viruses in periodontal diseases were categorized into the role in disease etiology, role in the pathogenesis of periodontal diseases, role in diseases progression and role in response to treatment. Clearer understandin...

  7. Functional role(s) of phagosomal Rab GTPases

    Science.gov (United States)

    Gutierrez, Maximiliano Gabriel

    2013-01-01

    Rab GTPases are at the central node of the machinery that regulates trafficking of organelles, including phagosomes. Thanks to the unique combination of high quality phagosome purification with highly sensitive proteomic studies, the network of Rab proteins that are dynamically associated with phagosomes during the process of maturation of this organelle is relatively well known. Whereas the phagosomal functions of many of the Rab proteins associated with phagosomes are characterized, the role(s) of most of these trafficking regulators remains to be identified. In some cases, even when the function in the context of phagosome biology is described, phagosomal Rab proteins seem to have similar roles. This review summarizes the current knowledge about the identity and function of phagosomal Rab GTPases, with a particular emphasis on new evidence that clarify these seemingly overlapping Rab functions during phagosome maturation. PMID:24088602

  8. teashirt is required for head-versus-tail regeneration polarity in planarians

    Science.gov (United States)

    Owen, Jared H.; Wagner, Daniel E.; Chen, Chun-Chieh; Petersen, Christian P.; Reddien, Peter W.

    2015-01-01

    Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with RNAi of the Wnt pathway genes β-catenin-1, wnt1, Dvl-1/2 or wntless. teashirt was required for β-catenin-1-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for Wnt-mediated specification of posterior blastemas. PMID:25725068

  9. The tale of the three brothers - Shh, Wnt and Fgf during development of the thalamus

    Directory of Open Access Journals (Sweden)

    Anja IH Hagemann

    2012-05-01

    Full Text Available The thalamic complex is an essential part of the brain that requires a combination of specialized activities to attain its final complexity. In the following review we will describe the induction process of the mid-diencephalic organizer (MDO where three different signaling pathways merge: Wnt, Shh and Fgf. Here, we dissect the function of each signaling pathway in the thalamus in chronological order of their appearance. First we describe the Wnt mediated induction of the MDO and compartition of the caudal forebrain, then the Shh mediated determination of proneural gene expression before discussing recent progress in characterizing Fgf function during thalamus development. Then, we focus on transcription factors, which are regulated by these pathways and which play a pivotal role in neurogenesis in the thalamus. The three signaling pathways act together in a strictly regulated chronology to orchestrate the development of the entire thalamus.

  10. POSSIBLE ROLES OF EPIPLOIC APPENDAGES

    Directory of Open Access Journals (Sweden)

    Flavia Di Noto

    2016-04-01

    Full Text Available Historically, only the energy storage function had been attributed to adipose tissue. However, recent studies have shown that it is also able to secrete several substances which act in a paracrine or endocrine manner, contributing to the maintenance of organism’s homeostasis. It has been reported that the visceral fat has distinctive secreting characteristics. Based on previous scientific observations, here we shall describe the possible functional role of epiploic appendages. The epiploic appendages may play an important role in the metabolic regulation and/or in immune defense through the secretion of specific factors, such as leptin and some inflammatory cytokines. Leptin has been seen to be involved both in the regulation of hunger signals, in coordination with the hypothalamus, and in complex immune defense processes. The exact understanding of the behavior of this hormone could play a key role in understanding the functions ascribed to the epiploic appendages.

  11. [The role in verbal communication].

    Science.gov (United States)

    Panini, Roberta; Fiorini, Fulvio

    2015-01-01

    The content of the thought is expressed by words articulated correctly according to grammar and syntax. The meanings are conveyed through words but also through the way they are used, the manner of communication. The real reason of communication is the intention, the purpose, often implicit, which determines the source of a speech. It is possible to identify a direct aim (the purpose of communicating) and an indirect objective (the role intention), understood as keeping a role between the speaker and the listener. The role is also indicated by the non-verbal or paraverbal component of the message, that is the tone of voice, the emphasis and the posture of the communicator. In the multitude of possible relationship (affective, social, business, political, religious), frequently bounded together, we can recognize three categories of relations: symmetrical, reciprocal and complementary.

  12. Digital Parenting and Changing Roles

    Directory of Open Access Journals (Sweden)

    Işıl KABAKÇI YURDAKUL

    2013-12-01

    Full Text Available Information and communication technologies are developing rapidly. Developing technologies are integrated in many fields of life. This situation facilitated almost all fields of life. Owing to integration process, children’s technology use and adaption is easy compare to their parents. But technology use and adaption brings several disadvantages for children. Computer and the Internet have been used nearly all home in about last five years. Parents who were worried about their children when they played outside are worried about their children when they are on net at home. Due to these developments, parenting notion has gain new different dimensions and parenting roles are changed. Parents should now be digital parent, the Internet Parent or online parent. In this paper Digital Parenting is examined and described in additon to thisdigital parenting roles are determined. Based on these roles recommendations are presented for future studies and practices

  13. Organizational Roles, Cognitive Roles, and Problem-Solving Styles.

    Science.gov (United States)

    Steckroth, Richard Lee; And Others

    1980-01-01

    Describes a study testing Korman's Model of Work Behavior which hypothesized that individuals will seek out and be satisfied with those roles that are most consistent with their self-evaluations or self-cognitions. The results of the study, which involved 96 managers, showed moderate support for Korman's thesis. (Author/LLS)

  14. Perceived Role Achievement and Role Expectation of Local ...

    African Journals Online (AJOL)

    USER

    Government Agricultural Programmes in Southeast, Nigeria ... Data were analysed using mean score, standard deviation and students' t-test. The mean scores for farmers on role expectation were, for provision of water scheme (2.7), market ..... a big gap in the understanding of the two groups of respondents about the.

  15. Osteoblast Role in Rheumatic Diseases

    Directory of Open Access Journals (Sweden)

    Addolorata Corrado

    2017-06-01

    Full Text Available Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK-RANK ligand (RANKL-osteoprotegerin (OPG signaling, bone morphogenetic proteins (BMPs pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases.

  16. The roles of viruses in periodontal diseases

    Directory of Open Access Journals (Sweden)

    C C Azodo

    2015-01-01

    Full Text Available The roles of bacteria in the etiopathogenesis of periodontal disease are well-understand, but that of the virus found in the periodontal environment are poorly understood. The aim of this literature review was to report the roles of viruses in periodontal diseases. The roles of viruses in periodontal diseases were categorized into the role in disease etiology, role in the pathogenesis of periodontal diseases, role in diseases progression and role in response to treatment. Clearer understanding of roles of viruses in periodontal diseases will facilitate the provision of effective periodontal disease prevention and treatment.

  17. Balancing multiple roles through consensus

    DEFF Research Database (Denmark)

    Oshima, Sae

    2014-01-01

    upon every client request or concern. However, simply yielding to the customer’s opinions can threaten the stylist’s role as a beauty expert, one who possesses their own professional standards. The analysis reveals that the participants frequently transform revision requests/offers into mutual...

  18. The freelance nurse writer role.

    Science.gov (United States)

    Sayers, B

    1999-01-01

    Freelance nurse writers are skilled in facilitating a dialogue and writing from the perspective of the group. This article, written by an experienced freelance author, describes efficient methods to incorporate information gleaned from group interviews. The author provides tips on what type of projects to look for, how to develop the role, and even how to charge.

  19. Role Attribute 1.0

    NARCIS (Netherlands)

    S. Pemberton (Steven); B. Adida (Ben); M. Birbeck (Mark); T.V. Raman; R. Schwerdtfeger

    2012-01-01

    htmlabstractThe Role Attribute defined in this specification allows the author to annotate markup languages with machine-extractable semantic information about the purpose of an element. Use cases include accessibility, device adaptation, server-side processing, and complex data description. This

  20. ISO 9000: The Librarian's Role.

    Science.gov (United States)

    Dobson, Chris; Ernst, Carolyn

    1999-01-01

    Describes the special library's role in implementing ISO 9000 (i.e., a series of international quality-assurance standards developed by the International Organization of Standards). Topics discussed include document and data control, keeping the standards current, documentation of procedures, the ISO 9000 audit, and benefits for the library. (MES)

  1. The Multiple Roles of Mentors

    Science.gov (United States)

    Sanchez, Sabrina R.; Roegman, Rachel; Goodwin, A. Lin

    2016-01-01

    Teaching Residents at Teachers College (TR@TC) is an 18-month program that prepares teachers for high-needs schools in New York City in two areas: teaching English to speakers of other languages (TESOL) and teaching students with disabilities. Student teachers, called residents, spend a year working with a mentor teacher. Mentors play three roles:…

  2. Transitioning between Work and Family Roles as a Function of Boundary Flexibility and Role Salience

    Science.gov (United States)

    Winkel, Doan E.; Clayton, Russell W.

    2010-01-01

    This study investigates the manner in which people separate their work and family roles and how they manage the boundaries of these two important roles. Specifically, we focus on how role flexibility and salience influence transitions between roles. Results indicate that the ability and willingness to flex a role boundary and role salience are…

  3. The Effect of Role Ambiguity and Role Conflict on Performance of Vice Principals: The Mediating Role of Burnout

    Science.gov (United States)

    Celik, Kazim

    2013-01-01

    Problem Statement: Role ambiguity and role conflict are considered issues that affect performance and lead to burnout. While numerous studies have analyzed role ambiguity or role conflict in relation to burnout or performance, few studies have studied all of these issues together. Since vice principals are expected to carry out a variety of…

  4. The Information and Communication Technology User Role: Implications for the Work Role and Inter-Role Spillover.

    Science.gov (United States)

    Piszczek, Matthew M; Pichler, Shaun; Turel, Ofir; Greenhaus, Jeffrey

    2016-01-01

    Management and organization research has traditionally focused on employees' work role and the interface between their work and family roles. We suggest that persons assume a third role in modern society that is relevant to work and organizations, namely the Information and Communication Technology User (ICTU) role. Based on role theory and boundary theory, we develop propositions about the characteristics of this role, as well as how ICTU role characteristics are related to boundary spanning activity, inter-role spillover with the work role, and work role performance. To this end, we first conceptualize the ICTU role and its associations with work and family roles. We then apply identity theory and boundary management theory to advance our understanding of how the ICTU role is related to criteria that are important to individuals and to organizations, namely self-selection into certain types of work roles and positive and negative inter-role spillover. The implications of this role for theory, research, and practice in management and organizations are discussed.

  5. The Information and Communication Technology User Role: Implications for the Work Role and Inter-Role Spillover

    Science.gov (United States)

    Piszczek, Matthew M.; Pichler, Shaun; Turel, Ofir; Greenhaus, Jeffrey

    2016-01-01

    Management and organization research has traditionally focused on employees’ work role and the interface between their work and family roles. We suggest that persons assume a third role in modern society that is relevant to work and organizations, namely the Information and Communication Technology User (ICTU) role. Based on role theory and boundary theory, we develop propositions about the characteristics of this role, as well as how ICTU role characteristics are related to boundary spanning activity, inter-role spillover with the work role, and work role performance. To this end, we first conceptualize the ICTU role and its associations with work and family roles. We then apply identity theory and boundary management theory to advance our understanding of how the ICTU role is related to criteria that are important to individuals and to organizations, namely self-selection into certain types of work roles and positive and negative inter-role spillover. The implications of this role for theory, research, and practice in management and organizations are discussed. PMID:28082936

  6. Putting Role 1 first: the Role 1 capability review.

    Science.gov (United States)

    Hodgetts, T J; Findlay, S

    2012-09-01

    To quantify the risk for delivering care at Role 1 in the Land Environment (point of wounding to hospital care) on current operations and set the conditions for systematic change to enhance future capability. UK, US and Danish Army Role 1 Subject Matter Experts (SMEs) (1) Questionnaire study ofUK SMEs to determine capability gaps; (2) Questionnaire study of US and Danish SMEs to benchmark UK capability; (3) Semi-structured interviews of UK SMEs; (4) In-theatre evaluation of deployed Role 1. Thirty two SMEs completed the questionnaire (68% response rate), comprising 25 medical officers (20 in clinical appointments; five in command and staff appointments), six nurses and one medical support officer. Results of the entire review were collated as a cross-Defence Lines of Development analysis, separating the specific experience of 1 Medical Regiment's Hybrid Foundation Training (HFT), Mission Specific Training (MST) and deployment cycle from the analysis gained from questionnaire studies, SME consultation and documentary evidence. The review generated 77 recommendations and 38 sub-recommendations. The top six messages of the review were (1) To balance the expressed desire to increase the ratio of trained Team Medics with the reality of generating credible instructors with clinical experience; (2) To recognise that inadequate experience for Combat Medical Technicians in Primary Healthcare in the Firm Base undermines their operational preparedness; (3) To recognise that Current Regimental Aid Post (RAP) at contingency without power lacks the rudimentary infrastructure of a modern Medical Treatment Facility; (4) To recognise that inappropriate deployment of personnel with chronic disease or acutely limiting conditions is a consistent trend for 20 years that highlights continuing system weaknesses in applying protective medical grading; (5) To accept that General Practitioner manning requires re-evaluating as an Operational Pinch Point, reviewing all options to maintain

  7. Crosstalk between Wnt Signaling and RNA Processing in Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Michael Bordonaro

    2013-01-01

    Full Text Available RNA processing involves a variety of processes affecting gene expression, including the removal of introns through RNA splicing, as well as 3' end processing (cleavage and polyadenylation. Alternative RNA processing is fundamentally important for gene regulation, and aberrant processing is associated with the initiation and progression of cancer. Deregulated Wnt signaling, which is the initiating event in the development of most cases of human colorectal cancer (CRC, has been linked to modified RNA processing, which may contribute to Wnt-mediated colonic carcinogenesis. Crosstalk between Wnt signaling and alternative RNA splicing with relevance to CRC includes effects on the expression of Rac1b, an alternatively spliced gene associated with tumorigenesis, which exhibits alternative RNA splicing that is influenced by Wnt activity. In addition, Tcf4, a crucial component of Wnt signaling, also exhibits alternative splicing, which is likely involved in colonic tumorigenesis. Modulation of 3' end formation, including of the Wnt target gene COX-2, also can influence the neoplastic process, with implications for CRC. While many human genes are dependent on introns and splicing for normal levels of gene expression, naturally intronless genes exist with a unique metabolism that allows for intron-independent gene expression. Effects of Wnt activity on the RNA metabolism of the intronless Wnt-target gene c-jun is a likely contributor to cancer development. Further, butyrate, a breakdown product of dietary fiber and a histone deacetylase inhibitor, upregulates Wnt activity in CRC cells, and also modulates RNA processing; therefore, the interplay between Wnt activity, the modulation of this activity by butyrate, and differential RNA metabolism in colonic cells can significantly influence tumorigenesis. Determining the role played by altered RNA processing in Wnt-mediated neoplasia may lead to novel interventions aimed at restoring normal RNA metabolism for

  8. The Role of Nuclear Diplomacy

    Directory of Open Access Journals (Sweden)

    S. Sriwidjaja

    2007-01-01

    Full Text Available In the midst of nuclear countries and non-nuclear countries in the framework of non-proliferation and disarmament, Indonesia has played an important role. Indonesia has been actively involved in each activity at the international level to create a world free from nuclear weapons. This involvements needs to be maintained and increased in the years to come. As a large country, Indonesia should play a key role in the field of nuclear diplomacy. All of the efforts of nuclear diplomacy as mentioned above had a clear objective to support Indonesia’s energy program, at the institution framework as well as capacity building. Indonesia’s effort is also directed to attain appropriated international public acceptance.

  9. Immunonutrition: the role of taurine.

    LENUS (Irish Health Repository)

    Redmond, H P

    2012-02-03

    Taurine is a sulfonated beta amino acid derived from methionine and cysteine metabolism. It is present in high concentrations in most tissues and in particular in proinflammatory cells such as polymorphonuclear phagocytes. Initial investigation into the multifaceted properties of this non-toxic physiologic amino acid revealed a link between retinal dysfunction and dietary deficiency. Since then a role for this amino acid has been found in membrane stabilization, bile salt formation, antioxidation, calcium homeostasis, growth modulation, and osmoregulation. Our own group has demonstrated a key role for taurine in modulation of apoptosis in a variety of cell types. This review summarizes our current knowledge of taurine in nutrition, host proinflammatory cell homeostasis, therapeutic applications, and its potential immunoregulatory properties. It is our belief that taurine, similar to arginine and glutamine, is now more than worthy of critical clinical analysis.

  10. Role of MYC in Medulloblastoma

    Science.gov (United States)

    Roussel, Martine F.; Robinson, Giles W.

    2013-01-01

    Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosis (Roussel et al. 1979) and its cloning (Vennstrom et al. 1982), c-MYC (MYC), as well as its paralogs MYCN and MYCL1, has been shown to play essential roles in cycling progenitor cells born from proliferating zones during embryonic development, and in all proliferating cells after birth. MYC deletion induces cell-cycle exit or cell death, depending on the cell type and milieu, whereas MYC and MYCN amplification or overexpression promotes cell proliferation and occurs in many cancers. Here, we review the relationship of MYC family proteins to the four molecularly distinct medulloblastoma subgroups, discuss the possible roles MYC plays in each of these subgroups and in the developing cells of the posterior fossa, and speculate on possible therapeutic strategies targeting MYC. PMID:24186490

  11. Cultural management and government role

    Directory of Open Access Journals (Sweden)

    Edalat Nemati

    2012-08-01

    Full Text Available Culture plays an important role on human lives and it has been in four ancient civilizations of China, Iran, Egypt and Greece. The civilization achievements are normally categorized in two different groups of material and immaterial. Practical experience of the material, social objective is called as a civilization and the mental aspect of spiritual experiences, spiritual and personal is called culture. The purpose of this research is to find a framework for cross-cultural management. First, we define the cultural planning and we review the existing cultural examples in Iranian society and try to provide an overall analysis. The paper also investigates the role of government on creating adaptive culture within the society and explains that government must act as leadership in creating value added culture.

  12. Role of magnesium in hypertension.

    Science.gov (United States)

    Sontia, Bruno; Touyz, Rhian M

    2007-02-01

    Magnesium affects blood pressure by modulating vascular tone and reactivity. It acts as a calcium channel antagonist, it stimulates production of vasodilator prostacyclins and nitric oxide and it alters vascular responses to vasoactive agonists. Magnesium deficiency has been implicated in the pathogenesis of hypertension with epidemiological and experimental studies demonstrating an inverse correlation between blood pressure and serum magnesium levels. Magnesium also influences glucose and insulin homeostasis, and hypomagnesemia is associated with metabolic syndrome. Although most epidemiological and experimental studies support a role for low magnesium in the pathophysiology of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of hypertension is unclear. The present review addresses the role of magnesium in the regulation of vascular function and blood pressure and discusses the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia.

  13. The role of big laboratories

    CERN Document Server

    Heuer, Rolf-Dieter

    2013-01-01

    This paper presents the role of big laboratories in their function as research infrastructures. Starting from the general definition and features of big laboratories, the paper goes on to present the key ingredients and issues, based on scientific excellence, for the successful realization of large-scale science projects at such facilities. The paper concludes by taking the example of scientific research in the field of particle physics and describing the structures and methods required to be implemented for the way forward.

  14. Pharmacist's Role in Diabetes Care

    Centers for Disease Control (CDC) Podcasts

    2008-05-19

    This podcast is for a professional audience and discusses the role pharmacists can play on the diabetes care team, through collaborative practice agreements and medication therapy management.  Created: 5/19/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Diabetes Translation (DDT), National Diabetes Education Program (NDEP).   Date Released: 6/4/2008.

  15. Role Attribute 1.0

    OpenAIRE

    Pemberton, Steven; Adida, Ben; Birbeck, Mark; Raman, T.V.; Schwerdtfeger, R.

    2012-01-01

    htmlabstractThe Role Attribute defined in this specification allows the author to annotate markup languages with machine-extractable semantic information about the purpose of an element. Use cases include accessibility, device adaptation, server-side processing, and complex data description. This attribute can be integrated into any markup language. In particular, schema implementations are provided to facilitate with languages based upon XHTML Modularization [XHTML-MODULARIZATION11-2e]. The ...

  16. Teaching leadership with role theory.

    Science.gov (United States)

    Holle, M L; Blatchley, M E

    1989-01-01

    A model based on Mintzberg's use of role theory to describe managerial functions was applied to nursing education. The model builds on interpersonal, informational, and decisional activities of managers (Mintzberg, 1978), and identifies nine subroles that are frequently carried out by managers in nursing. Organization of material using this structure has been well-accepted both by baccalaureate nursing students and by practicing nurses whose educational background in management concepts is limited.

  17. Role ambiguity, employee gender, and workplace friendship.

    Science.gov (United States)

    Chen, Chien-Yu; Mao, Hsiao-Yen; Hsieh, An-Tien

    2012-06-01

    The importance of workplace friendship is recognized by researchers and practitioners, but its antecedents with respect to work roles are not well understood. Employees' gender might moderate a relationship between work roles and friendships. Data from a survey of 221 international tourist hotel employees showed that a key aspect of job support, role ambiguity, was negatively related to having workplace friendships. However, employees' gender did not moderate this relationship. Role clarity (the opposite of role ambiguity) may facilitate workplace friendships.

  18. The Role of CGRPin Nociception?

    Directory of Open Access Journals (Sweden)

    R. G. Hill

    2001-01-01

    Full Text Available The failure of NK1 receptor antagonists to show analgesic activity in clinical trials in spite of abundant preclinical evidence for a role of this neuropeptide in nociception, makes it somewhat dangerous to speculate on the nociceptive role of other neuropeptides, especially with respect to therapeutic utility of receptor antagonists! However, CGRP is the primary afferent peptide with the strongest evidence of a role in pain perception. It is found in a greater proportion of sensory neurones than other peptides and is a constituent of A[delta ] as well as C-fibres. Inflammation of peripheral tissues upregulates production of CGRP in sensory ganglia, coincident with the development of hyperalgesia, and CGRP knockout mice have attenuated hyperalgesic responses. CGRP is released into the dorsal horn of the spinal cord (DHSC by noxious peripheral stimuli and excites nociceptive DHSC neurones on local application. The peptide antagonist CGRP8-37 blocks the response to exogenous CGRP and can reduce the response of DHSC neurones to noxious peripheral stimuli. CGRP8-37 has also been shown to have behavioural antinociceptive properties when given intrathecally. Conversely, injection of CGRP itself to the PAG or n. accumbens has been reported to have antinociceptive effects that are reversed by CGRP8-37. With the advent of potent non-peptide antagonists such as BIBN4096BS we should soon be able to determine whether systemic blockade of all CGRP receptors produces antinociception without limiting side effects.

  19. [The father's role and dysorexia].

    Science.gov (United States)

    Marocco Muttini, C

    1993-09-01

    Of all eating disorders it is widely acknowledged that dysrexia has increased; this syndrome appears most frequently to affect the more affluent socio-economic classes. This paper focuses on a single case from which more general conclusions are then drawn. After an earlier episode of bulimia, a girl suffering from anorexia was found to live in a family context in which the father provided a weak psychological reference point. He was often away on work during the girl's childhood and only takes part in the family life as the provider of material wellbeing without playing a direct affective or pedagogical role. A situation of this type represents a way of fulfilling family roles in today's society where ensuring the family's comfortable lifestyle acts as a substitute for the affective role which the parent is not able to sustain due to unresolved neurotic nuclei. Society can now augment certain forms of defence in view of efficiency and productivity which detract from a genuine personal evolution. This leads to the development of neuroses in the younger generation which the mental health services must identify and correct using new psychopedagogic proposals.

  20. Role of leptin in reproduction.

    Science.gov (United States)

    Bajari, Tarek M; Nimpf, Johannes; Schneider, Wolfgang J

    2004-06-01

    This article focuses on recently gained knowledge concerning the different emerging aspects of the role of leptin in reproduction, through both its central hypothalamus-mediated and peripheral actions. As delineated in murine models, STAT3-independent signals triggered by the leptin receptor are clearly important in fertility, and candidate pathways such as those via phosphatidylinositol-3 kinase and extracellular signal-related kinase are implicated in leptin-regulated cascades. Another aspect whose importance has recently been revealed is that of the bioavailability of leptin in general, and the fate and action of carrier-bound versus free leptin at central and peripheral sites in particular. Besides the well-established role of leptin in the control of appetite and energy expenditure in humans and animals, evidence for a major involvement of the hormone in the function of the reproductive system is rapidly accumulating through physiological and molecular genetic approaches. Powerful animal models that facilitate the dissection of increasingly complex pathways, together with detailed studies in man, will soon delineate in detail the diverse roles of leptin in biological regulation. The development of therapeutic agents primarily directed against obesity must therefore take into consideration the consequences of treatment not only on the amelioration of leptin resistance, but also on the bioactivity of leptin in the context of growth, glucose homeostasis, and last but not least, fertility.

  1. Role strain in occupational therapy fieldwork educators.

    Science.gov (United States)

    Barton, Rebecca; Corban, Ashley; Herrli-Warner, Lauren; McClain, Emily; Riehle, Danielle; Tinner, Eboni

    2013-01-01

    The purpose of this study was to determine if occupational therapy fieldwork educators are experiencing role strain. Were recruited from a convenience sample of a university database of 315 fieldwork sites. The Role Strain in Occupational Therapy Fieldwork Educators Inventory was used to gather qualitative and quantitative data about practice. The overall mean for role strain was 2.34/5 with a 73% return rate. The majority of participants fell into the moderate to low role strain category. Individuals with 5-10 years of practice had the greatest amount of role strain (2.43, SD 0.51, n=60). Participants working in pediatric settings had role strain in the moderate range. Nine items emerged with the highest amount of role strain, such as coping with job expectations and inadequate time to meet role expectations. Creation of strategies to reduce role strain should be a priority in our changing healthcare environment.

  2. Role Overload, Role Self Distance, Role Stagnation as Determinants of Job Satisfaction and Turnover Intention in Banking Sector.

    Science.gov (United States)

    Kunte, Monica; Gupta, Priya; Bhattacharya, Sonali; Neelam, Netra

    2017-01-01

    This study examined the relationship of the organizational role stress: Role overload, role self-distance, and role stagnation with job satisfaction and turnover intention with a sample of banking employees in India. In this research, we used the RODS scale developed by Prohit and Pareek (2010) for measuring occupational role scale. The reliability of the scale came out to be 0.71. The majority of employees of all ranks, in both private and public sector banks, suffer from high role stress of all types. It was found that role overload and role stagnation are inversely associated with banking employees' job satisfaction. Private sector bank employees have more role stress and more unsatisfied than employees of public sector banks. Employees Turnover intention was found to be positively impacted by job satisfaction, contrary to many other studies. Possible reasons have been suggested. Job satisfaction was found to play a partial mediating role in the relationship between role overload and turnover intention with 40% mediation. Further, employees with longer tenure (work experience) have less role stress and are more satisfied. This study is unique in the sense there is hardly any study linking role stress to job satisfaction and turnover intention, specially in Indian context.

  3. Role Overload, Role Self Distance, Role Stagnation as Determinants of Job Satisfaction and Turnover Intention in Banking Sector

    Science.gov (United States)

    Kunte, Monica; Gupta, Priya; Bhattacharya, Sonali; Neelam, Netra

    2017-01-01

    Purpose: This study examined the relationship of the organizational role stress: Role overload, role self-distance, and role stagnation with job satisfaction and turnover intention with a sample of banking employees in India. Methodology: In this research, we used the RODS scale developed by Prohit and Pareek (2010) for measuring occupational role scale. The reliability of the scale came out to be 0.71. Findings: The majority of employees of all ranks, in both private and public sector banks, suffer from high role stress of all types. It was found that role overload and role stagnation are inversely associated with banking employees' job satisfaction. Private sector bank employees have more role stress and more unsatisfied than employees of public sector banks. Employees Turnover intention was found to be positively impacted by job satisfaction, contrary to many other studies. Possible reasons have been suggested. Job satisfaction was found to play a partial mediating role in the relationship between role overload and turnover intention with 40% mediation. Further, employees with longer tenure (work experience) have less role stress and are more satisfied. Originality: This study is unique in the sense there is hardly any study linking role stress to job satisfaction and turnover intention, specially in Indian context. PMID:29200554

  4. About sleep's role in memory.

    Science.gov (United States)

    Rasch, Björn; Born, Jan

    2013-04-01

    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

  5. About Sleep's Role in Memory

    Science.gov (United States)

    2013-01-01

    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of “sleep and memory” research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems. PMID:23589831

  6. Interstitial pregnancy: role of MRI

    Energy Technology Data Exchange (ETDEWEB)

    Filhastre, M.; Lesnik, A. [Lapeyronie Hospital, Department of Radiology, Montpellier Cedex 5 (France); Dechaud, H.; Taourel, P. [Arnaud de Villeneuve Hospital, Department of Gynecology, Montpellier (France)

    2005-01-01

    We report the MRI features of two cases of interstitial pregnancy. In both cases, MRI was able to localize the ectopic pregnancy by showing a gestational structure surrounded by a thick wall in the upper part of the uterine wall separated from the endometrium by an uninterrupted junctional zone. Because US may confuse angular and interstitial pregnancies and because interstitial pregnancy has a particular evolutive course, MR imaging may play a key role in the diagnosis and management of women with interstitial pregnancy. (orig.)

  7. Osteoblast role in osteoarthritis pathogenesis.

    Science.gov (United States)

    Maruotti, Nicola; Corrado, Addolorata; Cantatore, Francesco P

    2017-11-01

    Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregulation of osteoblast function, bone remodeling, and mineralization, leading to osteoarthritis development. Moreover, osteoblasts produce numerous transcription factors, growth factors, and other proteic molecules which are involved in osteoarthritis pathogenesis. © 2017 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

  8. Betwixt and between: Role conflict, role ambiguity and role definition in project-based dual-leadership structures.

    Science.gov (United States)

    Ebbers, Joris J; Wijnberg, Nachoem M

    2017-11-01

    Project-based organizations in the film industry usually have a dual-leadership structure, based on a division of tasks between the dual leaders - the director and the producer - in which the former is predominantly responsible for the artistic and the latter for the commercial aspects of the film. These organizations also have a role hierarchically below and between the dual leaders: the 1st assistant director. This organizational constellation is likely to lead to role conflict and role ambiguity experienced by the person occupying that particular role. Although prior studies found negative effects of role conflict and role ambiguity, this study shows they can also have beneficial effects because they create space for defining the role expansively that, in turn, can be facilitated by the dual leaders defining their own roles more narrowly. In a more general sense, this study also shows the usefulness of analyzing the antecedents and consequences of roles, role definition, and role crafting in connection to the behavior of occupants of adjacent roles.

  9. I am my (high-power) role: power and role identification.

    Science.gov (United States)

    Joshi, Priyanka D; Fast, Nathanael J

    2013-07-01

    Research indicates that power liberates the self, but findings also show that the powerful are susceptible to situational influences. The present article examines whether enacting roles that afford power leads people to identify with the roles or, instead, liberates them from role expectations altogether. The results of three experiments support the hypothesis that power enhances role identification. Experiment 1 showed that enacting a particular role resulted in greater implicit and explicit role identification when the role contained power. In Experiment 2, infusing a role with power resulted in greater role identification and role-congruent behavior. Experiment 3 demonstrated that power resulted in greater role-congruent self-construal, such that having power in a close relationship caused participants to define themselves relationally, whereas having power in a group situation caused participants to embrace a collective self-construal. Implications for research on power, roles, and the self are discussed.

  10. Role of fibrinolysis in sepsis.

    Science.gov (United States)

    Gando, Satoshi

    2013-06-01

    Sepsis, defined as infection-induced systemic inflammatory response syndrome, invariably leads to hemostatic abnormalities ranging from insignificant coagulopathy to disseminated intravascular coagulation (DIC). The inflammation-induced activation of coagulation, the downregulation of physiologic anticoagulant pathways, and impairment of fibrinolysis play a pivotal role in the pathogenesis of microvascular fibrin thrombosis and multiple organ dysfunction syndrome (MODS) in DIC associated with sepsis. The balance between tissue plasminogen activator and plasminogen activator inhibitor-1 mainly regulates fibrinolytic activity. Thrombin-activatable fibrinolysis inhibitor and neutrophil elastase also modulate fibrinolysis. Dynamic changes in these molecules are deeply involved in the pathomechanisms of the impairment of fibrinolysis, leading to MODS in DIC associated with sepsis. Evidence indicates that physical entrapment of bacteria by fibrin at the site of infection may limit their capacity to disseminate into nearby tissues, organs, and systemic circulation. Under this circumstance, impairment of fibrinolysis has protective role in the host defense. Given the protective and pathologic potential of fibrinolysis during sepsis, therapeutics that control DIC as a systemic syndrome, while maintaining the host defense at the infectious foci, are required for the protection against both the development of MODS and for the host defense mechanisms. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  11. Role-Playing in Consumer Economics Education

    Science.gov (United States)

    Singleton, M. Wells; And Others

    1977-01-01

    Discusses the teacher's responsibilities in role-playing situations in consumer education; identifies four different kinds of simulations; and suggests six topics for role-playing about consumer issues. (AV)

  12. Utilizing Peer Mentor Roles in Learning Communities

    Science.gov (United States)

    Rieske, Laura Jo; Benjamin, Mimi

    2015-01-01

    For a number of learning community programs, peer mentors provide an additional layer of staffing support. This chapter highlights peer mentor roles from a sample of programs and suggests important components for the construction of these roles.

  13. Identifying Role Diffusion in School Counseling

    Science.gov (United States)

    Astramovich, Randall L.; Hoskins, Wendy J.; Gutierrez, Antonio P.; Bartlett, Kerry A.

    2013-01-01

    Role ambiguity in professional school counseling is an ongoing concern despite recent advances with comprehensive school counseling models. The study outlined in this article examined role diffusion as a possible factor contributing to ongoing role ambiguity in school counseling. Participants included 109 graduate students enrolled in a…

  14. Gender, Gender Role, and Body Image.

    Science.gov (United States)

    Jackson, Linda A.; And Others

    This study examined the importance of gender and gender role in understanding self-perceptions of body image. Male and female college students (N=166) who differed in gender role as measured by the Bem Sex Role Inventory completed the Body-Self Relations Questionnaire, a new measure of body image containing 140 items which fit a 3 x 3 matrix that…

  15. Nature or Nurture? Gender Roles Scavenger Hunt

    Science.gov (United States)

    Whalen, Shannon; Maurer-Starks, Suanne

    2008-01-01

    The examination of gender roles and stereotypes and their subsequent impact on sexual behavior is a concept for discussion in many sex education courses in college and sex education units in high school. This analysis often leads to a discussion of the impact of nature vs. nurture on gender roles. The gender roles scavenger hunt is an interactive…

  16. Changing Instructor's Roles in Virtual Worlds

    Science.gov (United States)

    Berge, Zane L.

    2008-01-01

    Berge's Instructor's Roles Model categorized the instructor's roles as pedagogical, social, managerial, and technical. Developed more than a decade ago, this model described changing roles for instructors as they transitioned from in-person classrooms to teaching online. Today, as virtual worlds emerge and are being used as educational platforms,…

  17. Restaurant Role-Play in Psychology

    Science.gov (United States)

    Borya, Anthony

    2013-01-01

    Research methods is perceived as a technical and difficult topic by some students. Using role-play to teach it can make it more accessible, meaningful and engaging. Role-playing the familiar roles of customer and waiting staff at a restaurant and discussing the variables that may affect the size of tips can help students to learn some of the key…

  18. How to Turn Bystanders into Role Players.

    Science.gov (United States)

    Laird, Dugan; House, Ruth Sizemore

    1984-01-01

    To give trainees a deeper level of experience, instructors often use role plays. In a role play, of course, learners enact the situation rather than merely talk about it. In a significant way, role plays let learners escape the environment of the classroom in order to behave as they would in real life. (SSH)

  19. Family Roles, Alcoholism, and Family Dysfunction.

    Science.gov (United States)

    Alford, Karola M.

    1998-01-01

    Examines family roles in college undergraduates (N=748). Comparing role identification found no differences between children of alcoholics (ACOA) and non-ACOAs. Differences were found in participants from dysfunctional families. Results suggest a need for clinicians to re-think the use of role conceptualization in therapeutic work with ACOAs, with…

  20. Emerging Role of Information Communication Technologies in ...

    African Journals Online (AJOL)

    Emerging Role of Information Communication Technologies in Extension Service Delivery in Nigeria: A Review. ... MN Okeke, HU Nwalieji, CO Uzuegbunam ... It highlights the emerging role of ICTs in agricultural extension service delivery in Nigeria and suggests areas of improvement in fulfilling the roles. ICTs play ...

  1. Does the Role Checklist Measure Occupational Participation?

    Directory of Open Access Journals (Sweden)

    Tore Bonsaksen

    2015-07-01

    Full Text Available Background: Among the Model of Human Occupation (MOHO assessments, the Role Checklist is one of the most established. In spite of its widespread use, no studies have examined role examples and their association with the three embedded levels of doing, as established in the MOHO theory. Method: A cross-sectional survey of 293 respondents from the US, the UK, Japan, Switzerland, Sweden, and Norway produced 7,182 role examples. The respondents completed Part I of the Role Checklist and provided examples of each internalized role they performed. Responses were classified as occupational skill, occupational performance, or occupational participation. Results: Thirty-three percent of the examples were classified as examples of occupational participation, whereas 65% were classified as examples of occupational performance. Four roles linked mostly with occupational participation, another four roles linked mostly with occupational performance, and the two remaining roles were mixed between occupational participation and occupational performance. Discussion: The Role Checklist assesses a person’s involvement in internalized roles at the level of both occupational participation and occupational performance. There are differences among countries with regard to how roles are perceived and exemplified, and different roles relate differently to the occupational performance and occupational participation levels of doing. There are related implications for occupational therapists.

  2. Maternal Influences on Daughters' Gender Role Attitudes.

    Science.gov (United States)

    Ex, Carine T. G. M.; Janssens, Jan M. A. M.

    1998-01-01

    Studied the gender role attitudes of 165 adolescent girls as mediated by their mothers' attitudes and child-rearing styles. Overall, data demonstrate the importance of mothers in the development of daughters' gender role attitudes. Child-rearing style and maternal gender role attitudes are important, with maternal education and employment having…

  3. Role perceptions and reported actual role content of hospital nurses in Mainland China.

    Science.gov (United States)

    Lu, Hong; While, Alison E; Louise Barriball, K

    2008-04-01

    The study aimed to explore nurses' views and experiences regarding their working roles in Mainland China. Ministry of Health guidance relating to the hospital nurse's role has been widely used in Mainland China since 1982 but it does not adequately cover the development of new roles arising from recent health care system reforms. This has led to increasing concerns about the potential of role conflict and role ambiguity for nurses especially where role expectations are not reflected in actual role content leading to job dissatisfaction and higher turnover. A cross-sectional survey design using postal questionnaires comprising demographic questions and four scales measuring role perception and actual role content, job satisfaction, occupational stress, role conflict and role ambiguity was used. Five hundred and twelve hospital nurses in Beijing participated representing a response rate of 81%. Most respondents reported that staff nurses should undertake most of the roles described in the domain of patients' physical care, psychosocial and communication and professional aspects of patient care and patient care management and there was overall consensus regarding the roles of other health care personnel. Further, they reported that nurses always or sometimes carried out these roles. Different role perceptions were reported across educational groups. Additionally, nurses' ratings of role perception and actual role content were related to their ratings of job satisfaction, occupational stress, role conflict and role ambiguity (p actual role of nurses provides the basis for developing strategies to reduce resulting occupational stress, role conflict and role ambiguity and increase job satisfaction. Additionally the findings provide a basis for international comparison of actual nurse role content and the potential support needs of nurses from Mainland China who move to work in other health care systems.

  4. Nanotechnology: Role in dental biofilms

    Directory of Open Access Journals (Sweden)

    Bhardwaj Sonia

    2009-01-01

    Full Text Available Biofilms are surface- adherent populations of microorganisms consisting of cells, water and extracellular matrix material Nanotechnology is promising field of science which can guide our understanding of the role of interspecies interaction in the development of biofilm. Streptococcus mutans with other species of bacteria has been known to form dental biofilm. The correlation between genetically modified bacteria Streptococcus mutans and nanoscale morphology has been assessed using AFMi.e atomic force microscopy. Nanotechnology application includes 16 O/ 18 O reverse proteolytic labeling,use of quantum dots for labeling of bacterial cells, selective removal of cariogenic bacteria while preserving the normal oral flora and silver antimicrobial nanotechnology against pathogens associated with biofilms. The future comprises a mouthwash full of smart nanomachines which can allow the harmless flora of mouth to flourish in a healthy ecosystem

  5. Negotiating gender roles through media

    DEFF Research Database (Denmark)

    Gustafsson, Jessica

    in developing counties is rare. Moreover, new technology is not adopted by a stagnant society, but rather a society where social relations and identities are in constant flux (Tenhunen 2008: 529). One aspect of the Kenyan society that according to several scholars is undergoing changes at the moment...... is the family and so are subsequently gender relations. The African family is traditionally based on clear gender roles that influence resource distribution and power relations in the family (Kelbert and Hossain 2014: 24, Wamue-Ngare & Njoroge 2011: 10f). The traditional norms and views on family have long been...... faced with external influences such as Christianity (Oburu 2011: 154) and colonial rule (Wamue-Ngare & Njoroge 2011: 14) and the 2010 constitution is evidence that Kenya has adopted ‘universal’ ideas of gender equality even though implementation might take time. Scholars like Oburu (2011), Wamue...

  6. PHYSIOLOGICAL ROLE OF NATURAL CAROTINOIDS

    Directory of Open Access Journals (Sweden)

    A.N. Zav'yalova

    2008-01-01

    Full Text Available A system role of carotinoids in human organism and factors influencing on its bioavailability are described in this article. A data of content of carotinoids in some eatable plants and factual provision of German and Japanese population with β-carotin, and author's proper data of content of β-carotin in blood plasma of schoolchildren of St. Petersburg were presented. A factual provision of children with inflammatory and erosive ulcerous lesions of upper gastrointestinal tract (GIT with β-carotin was compared to disorders of food behavior: preference of «fast food» and rare use of fruits and vegetables.Key words: children, nutrition, carotinoids, diseases of gastrointestinal tract.

  7. Fluoride: its role in dentistry

    Directory of Open Access Journals (Sweden)

    Livia Maria Andaló Tenuta

    2010-01-01

    Full Text Available In spite of decades of research on fluoride and the recognition of its role as the cornerstone of dental caries reduction in the last fifty years, questions still arise on its use at community, self-applied and professional application levels. Which method of fluoride delivery should be used? How and when should it be used? How can its benefits be maximized and still reduce the risks associated with its use? These are only some of the challenging questions facing us daily. The aim of this paper is to present scientific background to understand the importance of each method of fluoride use considering the current caries epidemiological scenario, and to discuss how individual or combined methods can be used based on the best evidence available.

  8. Role of platelets in inflammation

    Directory of Open Access Journals (Sweden)

    Kadir Serkan Yalçın

    2012-09-01

    Full Text Available Inflammation, which is extremely useful process for humanbody is the response of living vascular tissues topathological phenomena that removes the pathogens andinitiates the healing procedure. Microorganisms, physicaltrauma, chemical, mechanical, irradiation, or thermal injury,ischemia and immune reactions are most commoncauses of this exceptionally important event for humanbody. Platelets are non-nucleated cells in blood that producedin bone marrow as derived from megakaryocytes.Apart from stop bleeding and achieving hemostasis thereare incredibly important roles of platelets in inflammation.Platelets contain important mediators for inflammationlike neutrophils or macrophages and can alter the courseof mechanism. In this article changing platelet function ininflammation and the effect of these functions to the processof inflammation will be discussed.Key words: Platelet, inflammation, cytokines

  9. Role Relationships in Research: Noticing an Elephant

    Directory of Open Access Journals (Sweden)

    Judith C. Lapadat

    2005-06-01

    Full Text Available Using a collaborative writing process, three researchers reflect on their role relationships as researchers engaged together in a classroom study. Researcher role relationships are revealed to be complex, multifaceted, and implicated in every choice and act on a moment-by-moment basis in the classroom and in the processes of the research. Personal dilemmas of role choices and power differentials, including how the power shifted according to what they chose to value and who could influence the classroom drama, are some of the role relationship themes that emerged. The improvisation of researcher role is theorizing situated in praxis.

  10. Psychiatrists' Perceptions of Role-Playing Games.

    Science.gov (United States)

    Lis, Eric; Chiniara, Carl; Biskin, Robert; Montoro, Richard

    2015-09-01

    The literature has seen a surge in research on the mental health impacts of technologies such as Facebook, video games, and massively-multiplayer online role-playing games such as World of Warcraft, but little is known regarding the mental health impact of non-video role-playing games, such as Dungeons & Dragons. The present study examines how psychiatrists' perceive role-playing games and whether they play them. Psychiatrists at a tertiary care centre in Canada completed a questionnaire assessing history of playing role-playing games and whether they associate them with psychopathology. Forty-eight psychiatrists responded. Twenty-three percent have played a role-playing game over their lifetimes. Twenty-two percent believed there was an association between psychopathology and role-playing games. A majority of psychiatrists who responded do not associate role-playing games with psychopathology. Implications for clinical practice and future research are discussed.

  11. Sex role charactersitics of males in nursing.

    Science.gov (United States)

    Fisher, M

    1999-09-01

    Sex role stereotypes are widely held concepts that attribute unique sets of characteristics to each sex. The feminine sex role stereotype coupled with the nature of nursing work, renders the profession more appropriate for females. Due to the pressures imposed by hegemonic masculinities, it is perceived that male nurses, as a consequence of their biological sex, are unable to possess the feminine sex role. A survey design was used to ascertain differences in sex role identity between male and female nurses in a contemporary Australian work force. The short form of the Bem Sex Role Inventory (BSRI) was distributed to 98 nurses to determine their perceived sex role identity. There was no significant difference between male and female nurses in masculine and feminine scores, and sex type categories. The results of this preliminary investigation supports the view that a significant proportion of male nurses see themselves having the personal attributes synonymous with the feminine sex role.

  12. I Play Roles, Therefore I Am

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Waade, Anne Marit

    2007-01-01

    The attention paid to live-action role-playing and other forms of leisure role-playing has exploded over the past few years, both due to the fact that the role-playing community continues to attract a lot of new members, the fact that role-playing as a creative, self-organizing and self......-reflecting activity is getting an increasingly growing attention from the media, and the fact that educators, teachers, and development consultants have discovered the potential inherent in role-playing, both as an idea and a strategy. In this essay, we place leisure role-playing in a broader perspective, not only...... in relation to actual phenomena in mediatized popular culture (such as computer games) or to storytelling in organizations, but also in relation to role-playing as a tradition and theoretical consideration within education, theatre, and the social sciences. The points and discussions are based on our book...

  13. Gender Role Conflict, Professional Role Confidence, and Intentional Persistence in Engineering Students in China

    Science.gov (United States)

    Yang, Xueyan; Wang, Xinhong; Zhang, Lin; Weidman, John C.

    2017-01-01

    In the current study, the relationship between gender role conflict, professional role confidence, and intentional persistence was examined using data from a survey of male and female Chinese engineering students. Intentional persistence was significantly associated with gender role conflict and professional role confidence; however, the pattern…

  14. The On-Site Mentor of Counseling Interns: Perceptions of Ideal Role and Actual Role Performance

    Science.gov (United States)

    Lazovsky, Rivka; Shimoni, Aviva

    2007-01-01

    This study examined the role of the ideal on-site mentor and the actual mentor's role performance, as perceived by 158 mentor counselors and 171 school counseling interns. Results indicated that the ideal mentor's professional traits were given priority by both groups and that the teacher role was the most salient among role domains. In the actual…

  15. CERN's role in medical applications

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    Last week, CERN hosted the first meeting of the International Strategy Committee for medical applications. This Committee will help CERN establish its roadmap in the field of research and development activities for medical applications. Here the CERN Bulletin speaks with the Chair of the Committee as he shares his expectations and his vision.   Dr Michael Baumann is the Director of the Radiation Oncology department at the Carl Gustav Carus University Hospital in Dresden and of the Institute for Radiooncology of the Helmholtz-Zentrum Dresden-Rossendorf (Germany). He has recently been appointed Chair of CERN’s International Strategy Committee for medical applications – the team of experts who will advise the CERN Medical Applications Study Group led by Steve Myers. “CERN has a tremendous record in physics and basic research,” says Baumann. “I think that it has a very important role in steering some of the R&D that cannot be done at universities ...

  16. Ritual's role in profound change.

    Science.gov (United States)

    1995-03-01

    In today's healthcare environment, characterized by downsizing, restructuring, mergers, and acquisitions, organizational cultures and employees are experiencing rapid--and often tense--changes. Ritual can facilitate change by acknowledging it and allowing the grieving process to take its course. The success of an organizational culture change can depend on whether the organization and its members have been given an opportunity to grieve. Until they grieve their losses, people cannot embrace the new. Organizational leaders who have survived downsizing must come to grips with their own survivor status first and then lead others in the organization through the current painful but irrevocable shift in their relationship to the organization. The use of ritual helps organizational survivors see the connection between the grieving process and their survivor symptoms of denial, anger, depression, guilt, fear, insecurity, anxiety, and uncertainty. A good ritual should allow those present to rise above barriers that separate, worries that overburden, and blindness that limits and to gather as one with God. As a rule, a good ritual is participative and recognizes the audience's diversity. The ritual should not just address those present but invite them to act, pray, or sing. Ritual is an important way to provide a structure that allows people to express their emotions. For leaders, it can be a visible way to acknowledge grief and show support for organizational members. For ritual to have any meaning, key leaders need to be present and perhaps have a role in the creation and enactment of the ritual.

  17. OCCUPATIONAL ROLE AFTER PSYCHIATRIC HOSPITALIZATION

    Directory of Open Access Journals (Sweden)

    GH.R GHASSEMI

    2003-03-01

    Full Text Available Introduction: Severe Psychiatricillness is accompanied by gross disturbances in patient's occupational role. This study presents a comparative picture of work performance before and after psychiatric hospitalization. Method: Subjects comprised 440 psychiatric admitters from Noor Medical center - Isfahan - Iran, who were followed from November 1999 to November 2000. Their work adjustment was measured by means of Weiss man's index. Data were computer analyzed using SPSS by running paired t- student and ANOVA. Results: Majority of the patients (53 % were without permanent sources of income before psychiatric hospitalization, about 12 percent of those who were working prior to hospitalization lost their job after being discharged from hospital. Better work adjustment before hospitalization was positively correlated with better work adjustment after discharge for working patients (r =0/66. Working ability of the patients after discharge was lesser than before the attack f9r patients with regular and irregular job (P < 001. Discussion: Job loss or poor working ability after psychiatric admission reported by several researchers and has bean confirmed in this study as well. These observatoins have been discussed in view of the current socio economic problems in the society and nature of psychiatric disturbances.

  18. Gender roles and sexual behaviour.

    Science.gov (United States)

    1997-01-01

    In social science studies, differences are identified between men's and women's perceptions of their own and the opposite sex's roles and responsibilities in society. In a Korean study of 849 school and university students, male respondents were significantly more accepting of their friends' sexual activities than were females. A study of 1000 young people in tertiary education institutions in Ilorin, Nigeria, found casual sex to be more than 5 times more common among males than among females. A study of young men and women in rural Thailand found that respondents who had not been married were more liberal about male premarital sexual activity than they were about women's activities. 98% of male and 44% of female factory workers surveyed in Chiang Mai, Thailand, believed premarital sex was acceptable for men. However, only 50% of the males and 15% of the females found such behavior acceptable for women. A study in Vietnam of the sexual behavior of university students found that a majority of both men and women believe sexual intercourse should occur only within marriage.

  19. Understanding Classroom Roles in Inquiry Education

    Directory of Open Access Journals (Sweden)

    Cheryl L. Walker

    2015-10-01

    Full Text Available Inquiry-based teaching and learning are rooted in social constructivism and are central to curricular reform. Role theory and social constructivism provided insight into a commonly observed but insufficiently understood phenomenon in inquiry. Within inquiry, role shifts have been described as the switching of roles between students and teachers; however, the process may be better conceptualized as role diversification because students and teachers may undertake multiple roles simultaneously in inquiry. This article expands on existing research and proposes a framework potentially applicable to both learners and teachers, but here focused on learners. Beyond exploration, engagement, and stabilization of roles, diversification was added and described. This framework expanded on current education theory, adding new insight to a minimally explored topic, with implications for students, teachers, consultants, and researchers.

  20. Emerging roles for eicosanoids in renal diseases.

    Science.gov (United States)

    Câmara, Niels O S; Martins, Joilson O; Landgraf, Richardt G; Jancar, Sonia

    2009-01-01

    Eicosanoids are products of arachidonic acid metabolism which have important roles in renal homeostasis and disease. In recent years the development of genetically modified animals and new drugs targeting eicosanoids producing enzymes and receptors has unveiled new roles for eicosanoids in kidney function. This review provides an overview of eicosanoid biosynthesis and receptors and discusses recent findings on their role in acute and chronic renal diseases and in renal transplantation. Products of the cyclooxygenases, 5-lipoxygenase, and cytochrome P450 pathways of arachidonic acid metabolism act through distinct receptors presented at different segment of the nephron. Apart from its role in renal physiology and hemodynamic, eicosanoids actively participate in the pathogenesis of acute and chronic renal diseases and have immunoregulatory role in kidney transplantation. The new discoveries on the role of eicosanoids in kidney functions and the development of drugs targeting eicosanoids synthesis or action should help to envisage novel therapeutic approaches for patients suffering from renal diseases.

  1. Effects of role variables on job satisfaction.

    Science.gov (United States)

    Sherman, E C

    1998-01-01

    This study examines the effects of role variables on job satisfaction among physician and non-physician executives in hospital settings. Positive relationships were found for both groups between role variables and job satisfaction. The results indicate that role variables have a significant effect on stress, job satisfaction, and organizational commitment in the physician executive and the non-physician health care executive. On a theoretical level, this research allowed for an extended test of role theory, specifically as it applies to the management of health care. The implications of these findings for role theory and the physician executive are discussed. Since this study is of an exploratory nature, it offers new insights into the field of health care management, and the physician's role as the executive.

  2. Project organization, roles and functions.

    Science.gov (United States)

    1986-06-01

    This discussion of the roles and functions in the integrated project which provides services in maternal and child health, family planning; nutrition, environmental sanitation, and income-generating projects in the Philippines covers the functions of the National Coordinating Committee, the Provincial Coordinating Committee, the Municipal Coordinating Committee, implementing units, the teams of development workers (TDWs), and coordinating/monitoring units. The National Coordinating Committee provides general directions and guidelines for the implementation of the project through the POPCOM/JICA central staff based at the POPCOM central office in Metro Manila. Functions of the Provincial Coordinating Committee include: resolve problems arising from issues of coordination involving members of the TDWs; ensure participation of provincial units of the various participating ministries; provide guidelines on the delivery of integrated services by TDWs; monitor the activities of TDWs, the municipal coordinating committee, and its various units; and review and endorse the city/provincial integrated project work plan to the regional office. The Municipal Coordinating Committee recommends policies to the national coordinating committee through the provincial coordinating committee to strenthen project implementation in the municipalities. Its functions include: resolve problems arising from issues involving the members of the TDWs; regularly monitor the activities of the TDWs; and provide assistance to the TDWs in the implementation of guidelines. Actual implementation of the project is carried out by the local government, represented by the barangay captain. He is assisted by the TDWs which come from various participating ministries of the government. The TDWs are in effect the task force of the municipal mayor who assist the barangay captain in the delivery of services and the conduct of information, education, and communication campaigns. 3 units assist the various

  3. Life's role in environmental regulation

    Science.gov (United States)

    Kump, L. R.

    2016-12-01

    The fusion of geological and biological perspectives on the operation of the Earth system is revolutionizing the way we think about the interactions of life and environment. No longer does life simply adapt to environmental change; those adaptations in turn modify the environment. Emerging from these interactions is the possibility of environmental regulation, the essence of Lovelock's Gaia Hypothesis. The long-term carbon cycle, for example, reflects a balance between the sources and sinks of carbon including volcanism, weathering of rocks exposed subaerially or on the seafloor, carbonate mineral formation, and the burial of organic carbon. The traditional view of these processes limits biological influences to the production and remineralization of organic matter and the formation of mineral skeletons. With the geobiological revolution we now also recognize the important role biological activity plays in accelerating weathering processes. Weathering rates depend on a variety of factors that we represent in numerical models with rate laws we adapt from inorganic chemistry. These can be characterized as zero-order (independent), first-order (linear), etc. and these functions are all monotonic. Yet one of the hallmark features of life is that it responds to changes in its environment parabolically: rates of physiological processes exhibit minima, optima, and maxima with respect to environment variables (temperature, pH, salinity, pO2, pCO2, . . .). Incorporation of physiological-style rate laws, and in general the explicit representation of life in models of Earth surface processes, demonstrates how the biota influence environmental stability on geologic time scales.

  4. Adoption Process of Instructors to Online Roles

    OpenAIRE

    BERİGEL, Muhammet; Karal, Hasan

    2013-01-01

    Online learning activities has started to rise in 1990s and continued to develop in 2000s with new instructional technologies. Online developments caused a dramatic evolution in instructors online roles, and raises fundamental questions about how instructors will adopt these changing roles for their teaching-learning activities. At this study adoption process of instructors online roles was investigated deeply using ethnographic case study methodology. Sample of study is 3 instructors at non-...

  5. The Role of Communication in Military Leadership

    OpenAIRE

    Monika Lewińska

    2015-01-01

    The aim of the paper is to discuss the role of communication in military leadership. First of all, basic terms related to communication, command and military leadership are explained. In the following parts of the paper it is intended to answer the question contained in the title: what is the role of communication in the military leadership? To precise the issue: is the role of communication in military organisations similar to civilian leadership and management or does it significantly differ?

  6. Roles of Variables and Program Analysis

    OpenAIRE

    Bishop, Craig; Johnson, Colin G.

    2005-01-01

    The idea of roles of variables is to provide a vocabulary for describing the way in which variables are used by experienced programmers. This paper presents work on a system that is designed to automatically check students' role assignments in simple procedural programming. This is achieved by applying program analysis techniques, in particular program slicing and data flow analysis, to programs that students have written and annotated with role assignments.

  7. THE ROLES OF MOSQUE LIBRARIES THROUGH HISTORY

    OpenAIRE

    Nurdin Laugu

    2007-01-01

    Since the formation of the Islamic society by prophet Muhammad, mosque libraries fulfilled several important roles that deserve scholarly attention. Therefore, this article elicits the significance of these various roles within Muslim societies through Islamic history. Until present day, almost all mosque libraries provide a variety of collections, concerning both religious and non-religious issues, such as social science and education. In line with these roles, this paper presents different ...

  8. The Role of Communication in Military Leadership

    Directory of Open Access Journals (Sweden)

    Monika Lewińska

    2015-06-01

    Full Text Available The aim of the paper is to discuss the role of communication in military leadership. First of all, basic terms related to communication, command and military leadership are explained. In the following parts of the paper it is intended to answer the question contained in the title: what is the role of communication in the military leadership? To precise the issue: is the role of communication in military organisations similar to civilian leadership and management or does it significantly differ?

  9. Kinerja Extra-Role Dan Kebijakan Kompensasi

    OpenAIRE

    Garay, Hannah.D Vanzuela

    2006-01-01

    The voluntary and spontaneity behavior of an individual to do errands outside his/her responsibility and current tasks for the sake of his/her organization's progress is found to be useful in boosting organizational effectiveness. This behavior is known as extra-role performance or organizational citizenship behavior (OCB). However, there are not many re¬searches done to study further on the role of compensation policy in the development of extra-role performance of the individual. The focal ...

  10. Gender role, sexual orientation and suicide risk.

    Science.gov (United States)

    Fitzpatrick, Kathleen Kara; Euton, Stephanie J; Jones, Jamie N; Schmidt, Norman B

    2005-07-01

    There has been interest in the relationship between homosexuality, gender role and suicide risk. Though homosexuals are more likely to identify as cross-gender, research has not simultaneously examined sexual orientation and gender role in assessing suicide risk. In the current study, the unique and interactive effects of sexual orientation and gender role were assessed in regard to suicidal ideation, related psychopathology and measures of coping. 77 participants were recruited from an undergraduate psychology subject pool (n=47) or from gay, lesbian and transgender student organizations (n=30) and assessed on measures of gender role, homosexuality, and psychopathology. Consistent with expectations, cross-gender role (i.e., personality traits associated with the opposite sex) is a unique predictor of suicidal symptoms. Moreover, gender role accounted for more of the overall variance in suicidal symptoms, positive problem orientation, peer acceptance and support, than sexual orientation. After accounting for gender role, sexual orientation contributed little to the variance in suicidal symptoms, associated pathology and problem-solving deficits. There was no support for gender role by sexual orientation interaction effects. The cross-sectional nature of the data limits statements regarding causality. Cross-gendered individuals, regardless of sexual orientation, appear to have higher risk for suicidal symptoms. Researchers and clinicians should assess gender role in evaluations of youth samples.

  11. The perspective of medical students regarding the roles and characteristics of a clinical role model.

    Science.gov (United States)

    Bahmanbijari, Bahareh; Beigzadeh, Amin; Etminan, Abbas; Najarkolai, Atena Rahmati; Khodaei, Marzieh; Askari, Seyed Mostafa Seyed

    2017-04-01

    As medical students spend most of their time with their clinical teachers and imitate their roles and characteristics during the school year, it is important to identify the roles and characteristics that they find essential in their role models. These traits play a part in their future professions as doctors. The aim of this study was to determine the perspective of students, interns, and residents regarding the roles and characteristics of a clinical role model. In an analytical cross-sectional study, a structured and self-developed questionnaire was completed by 185 medical students at educational hospitals of Kerman University of Medical Sciences during April and May 2015. Participants were selected using convenience sampling method. For data analysis, we used descriptive and inferential statistics. SPSS software version 16 was used as needed. In total, 90 medical students (48.7%), 65 interns (35.1%), and 30 residents (16.2%) participated in this study. Male respondents (n=75) comprised 40.5% and female respondents (n=110) 59.5% of the study sample. The three most important roles of a clinical teacher were organizer role (99.7), teacher role (101.7), and supporter role (109.5) for students, interns, and residents respectively. On the other hand, supporter role (85.4), communicator role (86.4) and organizer role (83.4) were ranked as the least important for students, interns, and residents respectively. There was no significant association among the three batches and the roles of a clinical teacher (p>0.05). Conversely, Females rated the roles of a clinical teacher significantly higher than males (pstudents as role models in medical schools, great attention should be given to their roles. Teachers must be aware that their roles have an impact on students' professional development and performance.

  12. A Role for TACI in Prostate Neoplasia

    Science.gov (United States)

    2008-01-01

    AD_________________ Award Number: W81XWH-05-1-0137 TITLE: A Role for TACI in Prostate Neoplasia ...NUMBER A Role for TACI in Prostate Neoplasia 5b. GRANT NUMBER W81XWH-05-1-0137 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT

  13. Higher Education Leadership Roles in Knowledge Processing

    Science.gov (United States)

    Martin, Jeffery S.; Marion, Russell

    2005-01-01

    Purpose: To examine the critical roles of leadership in higher education and to define how such roles enable an environment that embraces the demands of a knowledge-based organization. Design/methodology/approach: Through interviews with executive leadership in several higher education institutions, the ontology of knowledge management was…

  14. The Smallpox Threat: The School Nurse's Role

    Science.gov (United States)

    Martin, Mary E.; Didion, Judy

    2003-01-01

    Today, with the threat of bioterrorism and war, there is a new dimension to the traditional role of the school nurse. The smallpox threat to public health will invoke the school nurse's role as an educator, liaison, and consultant in the community. This article discusses smallpox, the vaccination process, adverse effects, and postvaccination care.…

  15. THE ROLE OF FORENSIC DENTIST FOLLOWING MASS ...

    African Journals Online (AJOL)

    and dental practitioners of the crucial role of dentist in victim's identification and to further motivate relevant ... role of forensic dental personnel in human identification following such occurrences. The various forensic dental modalities of .... dental or systemic diseases. Presence of erosion can suggest alcohol or substance ...

  16. Making Fashion Sustainable : The Role of Designers

    NARCIS (Netherlands)

    van der Velden, N.M.

    2016-01-01

    The dissertation ‘Making Fashion Sustainable – The Role of Designers’ describes the PhD research of Natascha M. van der Velden on the envisioned role designers could take responsibility for in the transition towards a more sustainable fashion industry.
    The current worldwide textile and apparel

  17. Invisible Roles of Doctoral Program Specialists

    Science.gov (United States)

    Bachman, Eva Burns; Grady, Marilyn L.

    2016-01-01

    The purpose of this study was to investigate the roles of doctoral program specialists in Big Ten universities. Face-to-face interviews with 20 doctoral program specialists employed in institutions in the Big Ten were conducted. Participants were asked to describe their roles within their work place. The doctoral program specialists reported their…

  18. Making a role for nurses in CCGs.

    Science.gov (United States)

    Moore, Alison

    2016-07-13

    What do nurses in clinical commissioning groups (CCGs) do? The answer is lots, but their role and influence varies greatly between CCGs. In May, a report from NHS Clinical Commissioners (NHSCC) - the membership organisation of CCGs - highlighted the key responsibilities of nurses and the important contribution they make in what are often pressured and demanding roles (see tinyurl.com/CCG-nurses ).

  19. The role of aspirin in women's health

    NARCIS (Netherlands)

    Verheugt, F.W.A.; Bolte, A.C.

    2011-01-01

    BACKGROUND: The aim of this review is to discuss the role of aspirin for various conditions in women. METHODS: A nonsystematic review of articles published on PubMed((R)) that examines the role of aspirin in women. RESULTS: Aspirin is associated with a significant reduction of stroke risk in women,

  20. Moving educational role-play beyond entertainment

    DEFF Research Database (Denmark)

    Duus Henriksen, Thomas

    2010-01-01

    Educational role-play has long proved an effective tool for consultants trying to develop the skills that employees are using for performing certain job functions. However, while educational role-play often is presented as an entertaining means for learning, such insistence on making learning gam...

  1. Occupations, Role Characteristics, and Intergenerational Transmission.

    Science.gov (United States)

    Spenner, Kenneth I.

    1981-01-01

    Analysis of correlations in role relationships involving parent occupation and child's career choice and occupational aspiration were made to determine which characteristics of occupations play a part in intergenerational role transmission. Requirements and rewards were found to be the salient features. (Author/SK)

  2. Patent, Nanotechnology, and the Role of University

    Directory of Open Access Journals (Sweden)

    Agus Sardjono

    2011-01-01

    Full Text Available University has significant contribution tot the development of nanotechnology, The role of university can be implemented through the TTLO, particulary in an effort to build a bridge for bottom-up nanotechnology for commercial purposes. There will be an increasingly significant link betweent the patent system on the university role in the development of nanotechnology.

  3. Processes and Roles In Remote Online Education

    DEFF Research Database (Denmark)

    Borch, Ole M.; Madsen, Per Printz; Helbo, Jan

    2005-01-01

    solving. Staff must be trained in the facilitator role and be experienced in using tools for development and using the educational digital platform. This article is mainly focusing on processes, staff and student roles in project work, course work, collaborative activities and how to perform exams...

  4. Role-Playing in Counselor Student Development

    Science.gov (United States)

    Osborn, Debra; Costas, Lisa

    2013-01-01

    This study examined how role-plays impacted 27 counseling students' overall skills as measured by instructor ratings and self-ratings during practice triads in a microskills course. A Mann-Whitney U nonparametric test revealed no significant difference for scripted versus personal concerns role-plays. Students indicated a strong belief that…

  5. Sales Role Play: An Online Simulation

    Science.gov (United States)

    Newberry, Robert; Collins, Marianne

    2017-01-01

    The online role play simulation as described in this article addresses critical skills as identified by practitioners and includes background materials, buyer and seller profiles, a sale/no-sale decision matrix, as well as a grading rubric, thereby facilitating a variety of selling scenarios. Both the buyer and the seller have integral roles in…

  6. Roles for vitamin K beyond coagulation

    Science.gov (United States)

    Recent interest in vitamin K has been motivated by evidence of physiological roles beyond that of coagulation. Vitamin K and vitamin K-dependent proteins may be involved in regulation of calcification, energy metabolism, and inflammation. However, the evidence for many of these proposed roles in the...

  7. [Role of innate immunity in tolerance induction].

    Science.gov (United States)

    Dolgikh, M S

    2015-01-01

    This review considers the role of innate immunity in mechanisms of transplant tolerance and rejection, analyse the role of innate immunity cells (dendritic cells-DC, NK, must and other cells) in these processes, and the pathes of creation of tolerogenic DC for transplant rejection therapy and tolerance.

  8. Student Perception of Faculty Role Models.

    Science.gov (United States)

    Lange, Brian; Friedman, Richard

    1985-01-01

    Questionnaires to compare faculty self-perceptions with dental students' perceptions of the role they desired to achieve are described. Results indicated a minimal relationship between the self-perceptions of faculty and the students' identification of their desired future role in the dental profession. (Author/MLW)

  9. The Role of the Primary School Head.

    Science.gov (United States)

    Davies, Lester

    1987-01-01

    This study uses Henry Mintzberg's structural observation method to examine British primary school head teachers' work patterns and determine the nature of their role. Head teachers' days were characterized by brevity, variety, and fragmentation similar to those discussed in findings of other empirical managerial studies. Leadership roles stressed…

  10. The Online School Librarian: Roles and Responsibilities

    Science.gov (United States)

    Beck, Dennis

    2015-01-01

    Children across the United States of America are maturing in a media-saturated society. Unfortunately, this often results in poor content choices and evaluative skills. North American schools have attempted to address this problem through information literacy skills. One role key to teaching these skills is the role of the school librarian.…

  11. Using Role Play to Debate Animal Testing

    Science.gov (United States)

    Agell, Laia; Soria, Vanessa; Carrió, Mar

    2015-01-01

    The use of animals in biomedical research is a socio-scientific issue in which decision-making is complicated. In this article, we describe an experience involving a role play activity performed during school visits to the Barcelona Biomedical Research Park (PRBB) to debate animal testing. Role playing games require students to defend different…

  12. Future role of fossil generation in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Kakaras, Emmanouil [European Power Plant Suppliers Association (EPPSA), Brussels (Belgium); Mitsubishi Hitachi Power Systems Europe GmbH, Duisburg (Germany); Latte, Tom de; Clerens, Patrick [European Power Plant Suppliers Association (EPPSA), Brussels (Belgium); Stein-Brzozwska, Gosia; Agraniotis, Michalis [Mitsubishi Hitachi Power Systems Europe GmbH, Duisburg (Germany)

    2016-04-01

    Thermal power plants have always played a crucial role in a safe and secure energy supply. In the last few years, however, there has been an increasing deployment of intermittent Renewable Energy Sources (i-RES). This means that European thermal power plants are now also asked to play a partner role to the irregular and fluctuating energy production from these i-RES.

  13. The democratic role orientation by journalists

    DEFF Research Database (Denmark)

    Svith, Flemming

    2017-01-01

    This paper investigates the democratic role orientation in news media and the perception and preference in the population towards the democratic practice of these news media.......This paper investigates the democratic role orientation in news media and the perception and preference in the population towards the democratic practice of these news media....

  14. The Role of Aesthetics in Web Design

    DEFF Research Database (Denmark)

    Thorlacius, Lisbeth

    2007-01-01

    is to present and discuss the four main areas in which aesthetics play an important role in the design of successful Web sites: aesthetics play an important role in supporting the content and the functionality, in appealing to the taste of the target audience, in creating the desired image for the sender...

  15. Role playing research before Dungeons and Dragons

    DEFF Research Database (Denmark)

    Lieberoth, Andreas

    of Dungeons and Dragons the hobby community quickly took up this more serious mantle as well. Looking to a few unfortunate cases, and the obvious psychological power of role playing experience, many came to believe that role playing can have a profound psychological impact, but few evidence based studies have......Role playing games as we know them today evolved as a merging between war games, fantasy literature and, shortly thereafter, historical enactment. Historically, practices akin to role-playing and simulation is quite a bit older as tools for learning or social meaning making, but after the birth...... been published (for a review, see Lieberoth & Trier-Knudsen, 2015). Sometimes the therapeutic concept of “”Psychodrama”” is evoked as an earlier 20th century case (and suggested efficacy) of role playing as a positive tool for personal and psychological change, but digging a bit deeper, it turns out...

  16. Social roles among recruits in Switzerland: Do social roles relate to alcohol use and does role change have an impact?

    Science.gov (United States)

    Kuntsche, Sandra; Astudillo, Mariana; Gmel, Gerhard

    2016-03-01

    Young men are likely to report high levels of alcohol use. Previous studies found a reduction in alcohol use when adopting adult social roles. This study examines the frequency of parenthood, partnership and stable employment among young men in Switzerland. It tests whether the alcohol use of those with adult social roles differs from those without and whether changes in social roles relate to changes in alcohol use. Data was available from 5025 men (20.0 years) at baseline (August 2010 to November 2011) and 15 months later. Changes in social roles and their impact on alcohol use were examined in multiple regression models. At baseline, 15.8% had a job and 4.9% a stable partner, and 1.5% had a child or were expecting one (30.5%, 6.1% and 2.2% at follow-up). Having a partner was associated with a significant decrease in annual frequency of drinking and weekly risky single-occasion drinking (RSOD) at follow-up. A higher number of social roles at follow-up was associated with a significant decrease in weekly RSOD. Apart from a significant decrease in weekly RSOD among those remaining in a stable partnership, role development was not found to have significant effects on alcohol use between baseline and follow-up. In Switzerland, an early engagement in permanent social roles is uncommon. Nevertheless, holding single or multiple social roles was commonly associated with reduced alcohol use, although not always significantly so. In western European countries, the engagement in adult social roles is postponed to later ages. Copyright © 2015. Published by Elsevier Ltd.

  17. Role Conflict and Role Ambiguity of Chief Executive Officers in International Joint Ventures

    OpenAIRE

    Oded Shenkar; Yoram Zeira

    1992-01-01

    This study examines the organizational and personal correlates of role conflict and role ambiguity of chief executive officers heading international joint ventures. Role conflict was found to be lower when the number of parent firms was higher and when the CEO had spent more years with the organization. Role ambiguity was found to be lower when the CEO had more years of education, when the Power Distance and Masculinity/Femininity gap between parents were lower, and when the Individualism/Col...

  18. Performance Implications of In-role and Extra-role Behavior of Frontline Service Employees

    OpenAIRE

    D. VANDAELE; P. GEMMEL

    2006-01-01

    Despite the growing body of literature on different employee behaviors such as organizational citizenship behavior or boundary spanning behavior, few research studies have investigated the impact of both in-role and extra-role behavior on performance outcomes, especially in business services settings. In this study we investigate how in-role behavior, extra-role behavior, and their interrelation influences employee performed productivity and quality in business security services. Data from 1,...

  19. Nurse Practitioner Role Transition: A Concept Analysis.

    Science.gov (United States)

    Barnes, Hilary

    2015-01-01

    A concept analysis of nurse practitioner (NP) role transition. The Affordable Care Act is expected to provide 32 million Americans with health insurance, and NPs are gaining attention in addressing this increasing demand for healthcare providers. However, there is limited analysis of the transition from registered nurse to NP. Oftentimes, during this transition, there is a shift from an experienced, expert status to an inexperienced, novice status, with a subsequent loss of confidence in one's ability and competence. This can hinder successful role development and affect employment continuity within the first year of practice. NP role transition was examined using Walker and Avant's method of concept analysis. Electronic databases were searched using the terms role transition and nurse practitioner. Thirty articles from nursing, psychology, and business were included. The four defining attributes of NP role transition are absorption of the role, the shift from provider of care to prescriber of care, straddling two identities, and mixed emotions. Personal and environmental antecedents and consequences of the concept are identified. The development of empirical knowledge on NP role transition through further research is important in order for new-to-practice NPs to become high-quality, full-functioning providers. © 2014 Wiley Periodicals, Inc.

  20. Transsexual parenthood and new role assumptions.

    Science.gov (United States)

    Faccio, Elena; Bordin, Elena; Cipolletta, Sabrina

    2013-01-01

    This study explores the parental role of transsexuals and compares this to common assumptions about transsexuality and parentage. We conducted semi-structured interviews with 14 male-to-female transsexuals and 14 men, half parents and half non-parents, in order to explore four thematic areas: self-representation of the parental role, the description of the transsexual as a parent, the common representations of transsexuals as a parent, and male and female parental stereotypes. We conducted thematic and lexical analyses of the interviews using Taltac2 software. The results indicate that social representations of transsexuality and parenthood have a strong influence on processes of self-representation. Transsexual parents accurately understood conventional male and female parental prototypes and saw themselves as competent, responsible parents. They constructed their role based on affection toward the child rather than on the complementary role of their wives. In contrast, men's descriptions of transsexual parental roles were simpler and the descriptions of their parental role coincided with their personal experiences. These results suggest that the transsexual journey toward parenthood involves a high degree of re-adjustment, because their parental role does not coincide with a conventional one.

  1. Role expansion on interprofessional primary care teams: Barriers of role self-efficacy among clinical associates.

    Science.gov (United States)

    Giannitrapani, Karleen F; Soban, Lynn; Hamilton, Alison B; Rodriguez, Hector; Huynh, Alexis; Stockdale, Susan; Yano, Elizabeth M; Rubenstein, Lisa V

    2016-12-01

    Interprofessional team-based models of primary care that expand the role of clinical associates (CAs) are increasingly adopted in primary care practices. In this study we query team members of a newly implemented patient centered medical home (PCMH) to identify facilitators and barriers of occupational role self-efficacy, a belief of possessing the capacity to execute their new team based role effectively. 79 key informants, members of primary care teams at six Veterans Health Administration (VA) clinics, were interviewed to assess their experiences with implementing expanded roles for CAs. All sites had implemented Patient Aligned Care Teams, the VA's version of PCMH. Three themes that produced the self-efficacy necessary for successful role expansion of CAs were identified: (1) role training (2) time and resources for roles and (3) cross-disciplinary role agreement. Sub-themes emerged around role challenges. Training sub themes included incomplete or limited training, inconsistencies in trainings within a site, and not receiving training with team members. Insufficient resources sub-themes included limited time for expanded tasks, inadequate space, low staffing, and poor task mix. Cross-disciplinary agreement failed to occur specifically when there was insufficient coordination between medicine and nursing leadership about staff roles, poor primary care provider (PCPs) knowledge of the boundaries of staff roles, and lack of synchronicity between staff roles and what PCPs would like staff roles to include. These identified themes have implications for healthcare professionals working in interprofessional teams in a variety of settings and indicate the need for interdisciplinary leadership based solutions. Clarifying the factors that impact self-efficacy for the role expansion of PACT staff can inform strategies for role transformation for enhanced primary care delivery. Published by Elsevier Inc.

  2. Aggression toward gay men as gender role enforcement: effects of male role norms, sexual prejudice, and masculine gender role stress.

    Science.gov (United States)

    Parrott, Dominic J

    2009-08-01

    This study examined sexual prejudice and masculine gender role stress as mediators of the relations between male gender norms and anger and aggression toward gay men. Participants were 150 self-identified heterosexual men who completed measures of adherence to male gender role norms, sexual prejudice, masculine gender role stress, and state anger. Participants then viewed a video depicting intimate relationship behavior between 2 gay men, reported state anger a second time, and competed in a laboratory aggression task against either a heterosexual or a gay male. Results indicated that adherence to the antifemininity norm exerted an indirect effect, primarily through sexual prejudice, on increases in anger. Adherence to the status and antifemininity norms exerted indirect effects, also through sexual prejudice, on physical aggression toward the gay, but not the heterosexual, male. Findings provide the first multivariate evidence for determinants of aggression toward gay men motivated by gender role enforcement.

  3. Conflict of two roles. The issue of a dual role - parent as a teacher

    OpenAIRE

    Mejstříková, Kamila

    2012-01-01

    TITLE: A conflict of two roles. The issue of a dual role - parent as a teacher. RESUMÉ The topic of this thesis is the issue of two roles - a role of a teacher and a parent. The goal of the thesis is to research the main key features arising from the issue of the conflict of dual role of a parent and a teacher at the same time. The empirical part of the thesis tries to outline problems which the parents, or let me say, teachers experience in the home and school environment based on the fact t...

  4. Mexican-American adolescents' gender role attitude development: the role of adolescents' gender and nativity and parents' gender role attitudes.

    Science.gov (United States)

    Updegraff, Kimberly A; McHale, Susan M; Zeiders, Katharine H; Umaña-Taylor, Adriana J; Perez-Brena, Norma J; Wheeler, Lorey A; Rodríguez De Jesús, Sue A

    2014-12-01

    Gender development has long term implications for education and career endeavors and family formation behaviors, but we know very little about the role of sociocultural factors in developmental and individual differences. In this study, we investigated one domain of gender development, gender role attitudes, in Mexican-American adolescents (N = 246; 51 % female), using four phases of longitudinal data across 8 years. Data were collected when adolescents averaged 12.51 years (SD = 0.58), 14.64 years (SD = 0.59), 17.72 years (SD = 0.57), and 19.60 years of age (SD = 0.66). Mothers' and fathers' gender role attitudes also were assessed in Phases 1, 3, and 4. Findings revealed that gender attitude development varied as a function of the interaction between adolescents' nativity and gender. Among Mexico-born adolescents, females exhibited significant declines in traditional attitudes from early to late adolescence, but males' attitudes were stable over time. U.S.-born females and males, in contrast, did not differ in their gender attitude trajectories. Examining the links between mothers', fathers', and adolescents' gender role attitudes revealed within-person associations between mothers' and adolescents' gender role attitudes: on occasions when mothers reported more traditional attitudes relative to their own cross-time average, adolescents also reported more traditional attitudes than usual. In addition, fathers' more traditional gender role attitudes were associated with daughters', but not sons', more traditional gender role attitudes at the between-person level. The discussion focuses on the interpretation of Mexican-American adolescents' gender role attitude development from a cultural ecological perspective.

  5. Mexican American Adolescents’ Gender Role Attitude Development: The Role of Adolescents’ Gender and Nativity and Parents’ Gender Role Attitudes

    Science.gov (United States)

    Updegraff, Kimberly A.; McHale, Susan M.; Zeiders, Katharine H.; Umaña-Taylor, Adriana J.; Perez-Brena, Norma J.; Wheeler, Lorey A.; Rodríguez De Jesús, Sue A.

    2014-01-01

    Gender development has long term implications for education and career endeavors and family formation behaviors, but we know very little about the role of sociocultural factors in developmental and individual differences. In this study, we investigated one domain of gender development, gender role attitudes, in Mexican American adolescents (N = 246; 51% female), using four phases of longitudinal data across eight years. Data were collected when adolescents averaged 12.51 years (SD = 0.58), 14.64 years (SD = 0.59), 17.72 years (SD = 0.57), and 19.60 years of age (SD = 0.66). Mothers’ and fathers’ gender role attitudes also were assessed in Phases 1, 3, and 4. Findings revealed that gender attitude development varied as a function of the interaction between adolescents’ nativity and gender. Among Mexico-born adolescents, females exhibited significant declines in traditional attitudes from early to late adolescence, but males’ attitudes were stable over time. U.S.-born females and males, in contrast, did not differ in their gender attitude trajectories. Examining the links between mothers’, fathers’, and adolescents’ gender role attitudes revealed within-person associations between mothers’ and adolescents’ gender role attitudes: on occasions when mothers reported more traditional attitudes relative to their own cross-time average, adolescents also reported more traditional attitudes than usual. In addition, fathers’ more traditional gender role attitudes were associated with daughters’, but not sons’, more traditional gender role attitudes at the between-person level. The discussion focuses on the interpretation of Mexican American adolescents’ gender role attitude development from a cultural ecological perspective. PMID:24777649

  6. AFRICOM’s Role in Water Security

    Science.gov (United States)

    2012-06-01

    Command,” U.S. AFRICOM Public Affairs, March 17, 2009. U.S. ARMY WAR COLLEGE Center for Strategic Leadership 650 Wright Avenue Carlisle, PA 17103-5049 OFFICIAL BUSINESS AFRICOM’s Role in Water Securty ...AFRICOM’s Role in Water Security Cadet Christopher Best Water represents one of the great diplomatic and development opportunities of our time. It’s...AFRICOM’s role in preserving U.S. interests in Africa by fostering water security. It will start with a discussion of major water challenges facing

  7. Designing Goals for Online Role-Players

    OpenAIRE

    Montola, Markus

    2005-01-01

    The increasing popularity of massively multi-player online role-playing and the rise of the role-playing-related pervasive gaming create a new challenge for the digital gaming industry. The role-player audience is growing in addition to the digital gamer audience. Catering to the both crowds requires re-thinking in the game design. In this paper I propose that one of the most fundamental differences is the difference in goal structures and the idea of "meaningful" play between the two gaming ...

  8. Nursing role implications for family caregiving.

    Science.gov (United States)

    Grant, Marcia; Ferrell, Betty

    2012-11-01

    To describe the clinical, education, and research roles of professional nurses caring for family caregivers. DATA SCORES: Review of literature and Websites on the professional nursing role and family caregivers. The growing number of family caregivers of cancer patients will need education and support. The professional oncology nurse is best suited to assess, teach, and support these family caregivers, as well as contribute to the evidence base of these areas of practice. Professional nurses caring for oncology patients need to expand their role to include additional support and education of family caregivers. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Organizational role stress among medical school faculty members in Iran: dealing with role conflict

    Directory of Open Access Journals (Sweden)

    Brommels Mats

    2007-05-01

    Full Text Available Abstract Background Little research has been conducted to investigate role stress experienced by faculty members in medical schools in developing countries. This becomes even more important when the process of reform in medical education has already taken place, such as the case of Iran. The objectives of this study were to investigate and assess the level and source of role-related stress as well as dimensions of conflict among the faculty members of Iranian medical schools. Variables like the length of academic work, academic rank, employment position, and the departments of affiliation were also taken into consideration in order to determine potentially related factors. Methods A survey was conducted at three different ranks of public medical schools. The validated Organizational Role Stress Scale was used to investigate the level of role stress and dimensions of role conflict among medical faculty members. The response rate was 66.5%. Results The findings show that role stress was experienced in high level among almost all faculty members. All three studied medical schools with different ranks are threatened with relatively the same levels of role stress. Specific differences were found among faculty members from different disciplines, and academic ranks. Also having permanent position and the length of services had significant correlation with the level of role stress. The major role- related stress and forms of conflict among faculty members were role overload, role expectation conflict, inter-role distance, resource inadequacy, role stagnation, and role isolation. Conclusion The most role-related stressors and forms of conflict among faculty members include too many tasks and everyday work load; conflicting demands from colleagues and superiors; incompatible demands from their different personal and organizational roles; inadequate resources for appropriate performance; insufficient competency to meet the demands of their role; inadequate

  10. Organizational role stress among medical school faculty members in Iran: dealing with role conflict.

    Science.gov (United States)

    Ahmady, Soleiman; Changiz, Tahereh; Masiello, Italo; Brommels, Mats

    2007-05-29

    Little research has been conducted to investigate role stress experienced by faculty members in medical schools in developing countries. This becomes even more important when the process of reform in medical education has already taken place, such as the case of Iran. The objectives of this study were to investigate and assess the level and source of role-related stress as well as dimensions of conflict among the faculty members of Iranian medical schools. Variables like the length of academic work, academic rank, employment position, and the departments of affiliation were also taken into consideration in order to determine potentially related factors. A survey was conducted at three different ranks of public medical schools. The validated Organizational Role Stress Scale was used to investigate the level of role stress and dimensions of role conflict among medical faculty members. The response rate was 66.5%. The findings show that role stress was experienced in high level among almost all faculty members. All three studied medical schools with different ranks are threatened with relatively the same levels of role stress. Specific differences were found among faculty members from different disciplines, and academic ranks. Also having permanent position and the length of services had significant correlation with the level of role stress. The major role- related stress and forms of conflict among faculty members were role overload, role expectation conflict, inter-role distance, resource inadequacy, role stagnation, and role isolation. The most role-related stressors and forms of conflict among faculty members include too many tasks and everyday work load; conflicting demands from colleagues and superiors; incompatible demands from their different personal and organizational roles; inadequate resources for appropriate performance; insufficient competency to meet the demands of their role; inadequate autonomy to make decision on different tasks; and a feeling of

  11. Role of mast cells in cow metritis

    National Research Council Canada - National Science Library

    Wang Guo-Qing; Hou Jin-Long; Huang Huan-Yu; Yuan Chao-Wen

    2016-01-01

    Introduction: Bovine postpartum metritis causes great losses. Mast cell (MC)-released mediators participate in uterine inflammation and immune response, but their role in postpartum metritis in cows has not been...

  12. The role of the food industry.

    Science.gov (United States)

    Mettler, A E

    1986-01-01

    The role of the manufacturing food industry in relation to provision of foods for the weanling encompasses 4 main objectives viz. customer satisfaction, safety, providing product information and the maintenance of commercial viability. The effectiveness of the manufacturing food industry to fulfil these roles is judged by the customer wishing to buy for quality and convenience reasons, by the law of the land in meeting legal requirements for safety and labelling and by its generation of profit in terms of commercial viability. Whereas it is commonly expected that industry should fulfil a role in nutrition education this is seen as a primary role of health professionals whilst industry needs to provide full and detailed product information. The industry is highly creative in both its technological innovation and adaptation and works hard at trying to satisfy the requirements of consumers, the industry, health professionals and its critics.

  13. Role of MRI in Medical Diagnostics

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 11. Role of MRI in Medical Diagnostics. Rashmi Rao Ramesh Venkatesan Sairam Geethanath. General Article Volume 20 Issue 11 November 2015 pp 1003-1011 ...

  14. Father's Perceptions about Their Fathering Role

    Directory of Open Access Journals (Sweden)

    Tammy Lynn Stubley

    2015-04-01

    Full Text Available This literature review explores scholarly contributions about the historical factors and modern day considerations that have served to shape our understanding of the fathering role. Human history has bared witness to significant shifts in perceptions concerning the role of the patriarch within the context of both familial and social structures. Socio-economic factors have served to shape the modern conceptualization of fatherhood. Fathers must face both external and internal attitudes about their role. The impact of these attitudes and the systems they inform has led to concerns about the parent-child attachment process. Global attitudes and expectation about the paternal role have also led to concerns about the safety and well-being of children. Faced with challenges that range from societal expectations and preconceived notions, to systemic challenges, fathers today must become strong advocates for their right to influence and participate in the lives of their children.

  15. AVP1: One Protein, Many Roles

    KAUST Repository

    Schilling, Rhiannon K.

    2016-12-16

    Constitutive expression of the Arabidopsis vacuolar proton-pumping pyrophosphatase (H+-PPase) gene (AVP1) increases plant growth under various abiotic stress conditions and, importantly, under nonstressed conditions. Many interpretations have been proposed to explain these phenotypes, including greater vacuolar ion sequestration, increased auxin transport, enhanced heterotrophic growth, and increased transport of sucrose from source to sink tissues. In this review, we evaluate all the roles proposed for AVP1, using findings published to date from mutant plants lacking functional AVP1 and transgenic plants expressing AVP1. It is clear that AVP1 is one protein with many roles, and that one or more of these roles act to enhance plant growth. The complexity suggests that a systems biology approach to evaluate biological networks is required to investigate these intertwined roles.

  16. Eurojust’s Fledgling Counterterrorism Role

    National Research Council Canada - National Science Library

    Oldrich Bures

    2010-01-01

    ... of Eurojust’s role in the fight against terrorism. The allegations concerning the existence of an inter-agency rivalry between Europol and Eurojust in the area of counterterrorism are also analyzed...

  17. Emergent leadership and female sex role identity.

    Science.gov (United States)

    Gurman, E B; Long, K

    1992-05-01

    The effects of female sex role identity on self- and rater evaluations of emergent leadership behavior were compared in two studies. We used the same consensus-seeking procedure in both studies to collect the data; only the biological sex composition of the groups in the second study was changed. Study 1 examined 15 mixed-sex groups of 39 female and 21 male students; Study 2 contained 96 female students in 22 same-sex groups. Sex role orientation was measured with the Bem Sex Role Inventory (BSRI: Bem, 1974). Androgynous and feminine-oriented self-ratings of leadership were significantly higher than peer ratings and were also significantly higher than the undifferentiated self-ratings. The self-ratings of masculine-oriented women agreed most closely with peer ratings. Contrary to research and theory, peer evaluation of leadership behavior by sex role orientation did not differ.

  18. An expanded role for river networks

    Science.gov (United States)

    Jonathan P. Benstead; David S. Leigh

    2012-01-01

    Estimates of stream and river area have relied on observations at coarse resolution. Consideration of the smallest and most dynamic streams could reveal a greater role for river networks in global biogeochemical cycling than previously thought.

  19. Glutathione role in gallium induced toxicity

    African Journals Online (AJOL)

    Asim

    2012-01-26

    GSH) present in tissues. It is very important and interesting to study the reaction of gallium nitrate and glutathione as biomarker of glutathione role in detoxification and conjugation in whole blood components (plasma and ...

  20. Essence and role of insurance sales management

    OpenAIRE

    N. Karlova

    2008-01-01

    Planning, organization, motivation and control as constituents of insurance products sales management process were considered in the article. Its important role in provision of financial reliability and paying capacity of insurance companies was demonstrated.

  1. Synaptogenesis: New Roles for an Old Player

    Science.gov (United States)

    Procko, Carl; Shaham, Shai

    2010-01-01

    The control of synapse formation and shape is important for establishing complex brain circuitry. New evidence now suggests that a component of a synaptic ion channel complex has an unexpected role in these processes. PMID:20064419

  2. Counselor Role Differentiation: A New Tack?

    Science.gov (United States)

    Carey, Albert R.; Garris, Donald

    1971-01-01

    The purpose of this exposition is to present a point of view regarding the differentiation of the counselor's role from other related helping professions, keeping the major function of counseling central in the argument. (Author/BY)

  3. Ethics of caring and professional roles.

    Science.gov (United States)

    Paulsen, Jens Erik

    2011-03-01

    Normative discussions about modern health care often revolve around principles stating what must not be done or how to ration scarce resources in the name of justice. These are important discussions. However, in order to have an impact on clinical roles, ethical reflection must be able to describe and address the complexities and challenges of modern nursing and doctoring, and maybe even the patient role. A multi-principled approach, such as the one suggested by Beauchamp and Childress, can obviously address almost any such issue, but a great deal of translation is often required in order to address role-related issues. I shall here argue that an ethics of caring is better suited to grasping the big picture when the question is how to create value-informed clinical roles in an era of rapid development.

  4. Ethnography and Communication: Social-Role Relations.

    Science.gov (United States)

    Rees, Norma S.

    1992-01-01

    This article addresses the concept of communication and social role including dimensions of speaker-listener relations, speaking options in these relations, and implications of language/learning-disabled individuals' failure to appreciate these dimensions and options. (DB)

  5. The Role of the Evaluation Research Broker.

    Science.gov (United States)

    Doty, Pamela

    1982-01-01

    In its role as a broker between the scientific community and the Congress, the Office of Technology Assessment evaluates the soundness of scientific conclusions for policy makers and ensures that research findings are included in formative policy analysis. (Author)

  6. The role accountants play in estate planning

    OpenAIRE

    Ştefan Zuca

    2006-01-01

    People commonly make plans for the orderly transfer of their property upon their death to relatives other persons, organizations, or trusts to be set up for the benefit of relatives. Such forethought is known as estate planning and is accomplished under the guidance of attorneys, often working closely with accountants. The attorney's role centers around preparing wills and, in many cases, trust agreements. The accountant's role consists of suggesting planning techniques consistent with the ob...

  7. Differential Fecundity, Markets and Gender Roles

    OpenAIRE

    Aloysius Siow

    1996-01-01

    Women are fecund for a shorter period of their lives than men. This paper investigates how differential fecundity interacts with marriage, labor and financial markets to affect gender roles. The main findings of the paper are: (i) Differential fecundity does not have any market invariant gender effect. (ii) Gender roles depend on competition for mates in the marriage market and the way in which ex-post differences in earnings affect that competition. (iii) Gender differences in the labor mark...

  8. The GDNF Family: A Role in Cancer?

    OpenAIRE

    Graeme C. Fielder; Teresa Wen-Shan Yang; Mahalakshmi Razdan; Yan Li; Jun Lu; Jo K. Perry; Peter E. Lobie; Dong-Xu Liu

    2018-01-01

    The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non–hormone-dependent solid neoplasms. The ability ...

  9. Immigrants and gender roles: Assimilation vs. culture

    OpenAIRE

    Francine D. Blau

    2015-01-01

    This paper examines evidence on the role of assimilation versus source country culture in influencing immigrant women's behavior in the United States – looking both over time with immigrants' residence in the United States and across immigrant generations. It focuses particularly on labor supply but, for the second generation, also examines fertility and education. We find considerable evidence that immigrant source country gender roles influence immigrant and second generation women's behavi...

  10. The role of glutathione in intestinal dysfunction.

    Science.gov (United States)

    Jefferies, Heather; Bot, Joan; Coster, Jane; Khalil, Alizan; Hall, John C; McCauley, Rosalie D

    2003-01-01

    Glutathione plays an important cytoprotective role in the gut. Animal studies have demonstrated that the provisions of glutathione precursors are protective for different types of free-radical-mediated cellular injury. There is a need to clarify the potential role of glutathione supplementation in ischemia-reperfusion injury and inflammatory bowel disease. More speculative is whether treatment with glutathione precursors can modify the progress of colorectal cancer.

  11. Antagonistic neural networks underlying differentiated leadership roles

    OpenAIRE

    Richard Eleftherios Boyatzis; Kylie eRochford; Anthony Ian Jack

    2014-01-01

    The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950’s. Recent research in neuroscience suggests that the division between task oriented and socio-emotional oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks -- the Task Positive Network (TPN) and the Default Mode Network (DMN). Neural activity in ...

  12. Medical student involvement in health policy roles.

    Science.gov (United States)

    Malik, Bassit; Ojha, Utkarsh; Khan, Hassan; Begum, Farzana; Khan, Harun; Malik, Qasim

    2017-01-01

    A teaching curriculum in health policy may be well established in medical school; however, an emphasis on applying taught principles via participation in health policy roles is less defined. We undertook a study to explore medical student participation in health policy roles. An anonymous online survey via convenience sampling was conducted in the UK. A total of 112 students from six medical schools participated in the study. The outcome measures were as follows: medical students' beliefs about their current knowledge of health policy and their desire to learn more; their current, past and future involvement in a health policy role, and perceived barriers to involvement. Forty-seven percent of participants reported previous teaching on health policy, with the majority scoring themselves 2 out of 5 for knowledge about the topic (38%). Seventy-seven percent of participants expressed a desire to be taught health policy while 73% agreed with compulsory teaching. Ninety-six percent of participants reported no current or previous activity in a health policy role, with 61% willing to undertake a role in the future. The three main barriers to student involvement were: a lack of knowledge about health policy (57%), an unawareness of opportunities available (56%), and a lack of time (43%). In addition to already established teaching programs within medical school, implementation of community-based experiences could improve knowledge of health policy, while providing an opportunity for students to gain experience in health policy committee roles.

  13. Roles of social impact assessment practitioners

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Cecilia H.M., E-mail: ceciliawonghm@gmail.com; Ho, Wing-chung, E-mail: wingcho@cityu.edu.hk

    2015-01-15

    The effectiveness of social impact assessment (SIA) hinges largely on the capabilities and ethics of the practitioners, yet few studies have dedicated to discuss the expectations for these professionals. Recognising this knowledge gap, we employed the systemic review approach to construct a framework of roles of SIA practitioners from literature. Our conceptual framework encompasses eleven roles, namely project manager of SIA, practitioner of SIA methodologies, social researcher, social strategy developer, social impact management consultant, community developer, visionary, public involvement specialist, coordinator, SIA researcher, and educator. Although these roles have been stratified into three overarching categories, the project, community and SIA development, they are indeed interrelated and should be examined together. The significance of this study is threefold. First, it pioneers the study of the roles of SIA practitioners in a focused and systematic manner. Second, it informs practitioners of the expectations of them thereby fostering professionalism. Third, it prepares the public for SIAs by elucidating the functions and values of the assessment. - Highlights: • We adopt systematic review to construct a framework of roles of social impact assessment (SIA) practitioners from literature. • We use three overarching categorises to stratify the eleven roles we proposed. • This work is a novel attempt to study the work as a SIA practitioner and build a foundation for further exploration. • The framework informs practitioners of the expectations on them thus reinforcing professionalism. • The framework also prepares the public for SIAs by elucidating the functions and values of the assessment.

  14. Role of vitamins in gastrointestinal diseases.

    Science.gov (United States)

    Masri, Omar A; Chalhoub, Jean M; Sharara, Ala I

    2015-05-07

    A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases. For instance, most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials, however interventional trials failed to prove a clear beneficial preventive role. On the other hand, more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities. Examples for this include the therapeutic role of vitamin E in patients with non-alcoholic steatohepatitis, the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus, the role of vitamin C in reducing the risk of gallstones, the positive outcome with vitamin B12 in patients with aphthous stomatitis, and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease. Other potential uses are yet to be elaborated, like those on celiac disease, pancreatic cancer, pancreatitis, cholestasis and other potential fields. Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years. Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost, their use should be encouraged in the fields where positive data are available.

  15. Shift in social order – shift in gender roles? Migration experience and gender roles

    Directory of Open Access Journals (Sweden)

    Tetiana Havlin

    2015-07-01

    Full Text Available Does gender matter in the context of immigration? What significance does it gain through time? Does transition from one gender role to another result in redistribution of family roles? These are the main questions which this paper addresses through scientific discourse and empiric research. In particular the paper deals with the question whether the transition from one gender role to another in the course of immigration triggers the liberalization of gender roles in the families of East-European immigrants (from Ukraine, Russia, Kazakhstan, and Armenia in Germany. This is investigated through semi-structured biographical interviews with female immigrants to Germany conducted by the author in 2012-2014. The findings illustrate a specific shift of gender roles in the context of migration. On the one hand, willingly or through circumstances, immigrant women are more likely to be involved in the decision-making process, to adapt to a breadwinner role, and to undertake the communication functions with official institutions (often due to better language proficiency. On the other hand, men are more likely to be more engaged in the caregiver roles for offspring, to maintain native language in communication with children (from mother tongue to ‘father tongue’, and to fulfill housekeeping duties. These patterns are rather untypical for post-soviet gender roles, with their increasing tendency to the renaissance of traditional gender roles. The question of whether a shift in gender roles related to migration from one country to another leads towards the greater liberalization of gender roles still remains debatable. But migration experience reinforces the transformation of gender roles which initially are not only distinct but also unequal. Thus, migration can accelerate restructuring of the gender relationship. In turn, a new social order imposes – on immigrants – a demand for greater flexibility of gender roles in the family and for diversity in

  16. Evidence for the social role theory of stereotype content: observations of groups' roles shape stereotypes.

    Science.gov (United States)

    Koenig, Anne M; Eagly, Alice H

    2014-09-01

    In applying social role theory to account for the content of a wide range of stereotypes, this research tests the proposition that observations of groups' roles determine stereotype content (Eagly & Wood, 2012). In a novel test of how stereotypes can develop from observations, preliminary research collected participants' beliefs about the occupational roles (e.g., lawyer, teacher, fast food worker, chief executive officer, store clerk, manager) in which members of social groups (e.g., Black women, Hispanics, White men, the rich, senior citizens, high school dropouts) are overrepresented relative to their numbers in the general population. These beliefs about groups' typical occupational roles proved to be generally accurate when evaluated in relation to data from the Bureau of Labor Statistics. Then, correlational studies predicted participants' stereotypes of social groups from the attributes ascribed to group members' typical occupational roles (Studies 1a, 1b, and 1c), the behaviors associated with those roles (Study 2), and the occupational interest profile of the roles (Study 3). As predicted by social role theory, beliefs about the attributes of groups' typical roles were strongly related to group stereotypes on both communion and agency/competence. In addition, an experimental study (Study 4) demonstrated that when social groups were described with changes to their typical social roles in the future, their projected stereotypes were more influenced by these future roles than by their current group stereotypes, thus supporting social role theory's predictions about stereotype change. Discussion considers the implications of these findings for stereotype change and the relation of social role theory to other theories of stereotype content. 2014 APA, all rights reserved

  17. EXAMINING THE EFFECTS OF ROLE CONFLICT AND ROLE AMBIGUITY ON BURNOUT AND JOB SATISFACTION

    Directory of Open Access Journals (Sweden)

    EBRU TOLAY SABUNCUOĞLU

    2013-06-01

    Full Text Available In this study, the effects of role conflict and role ambiguity on burnout and job satisfaction are examined with a survey whose respondents are 71 research assistants working in the Faculty of Economics and Administrative Sciences at Dokuz Eylül University. Therefore, a model was developed in order to determine the cause-effect relationships among variables and the path analysis was utilized to test the model. According to the results of this study, it was determined that role conflict and role ambiguity reduce job satisfaction by means of increasing the emotional exhaustion and depersonalization which are burnout dimensions, and thus there is mediating effect of burnout between role conflict-job satisfaction and role ambiguity-job satisfaction.

  18. Extra-role behavior modelling: personality concept and the role of servant leadership

    OpenAIRE

    ISMAIL VERNI Y.; ARMANU A.; HADIWIDJOJO DJUMILAH; INDRAWATI NUR KHUSNIYAH

    2016-01-01

    Nowadays, extra-role behavior has become one of the important outcomes for organization. Because in order to achieve their success; organizations need employees who are willing to do more work than what they are supposed to do. The purpose of this article is to develop extra-role behavior model based on personality concept as employee’s internal factor, and the role of servant leadership in organizational environment. Personality concept is developed using two approaches, namely traits approa...

  19. Impact and role of justice types and identification on extra role behavior

    OpenAIRE

    Salojärvi, Samuli

    2014-01-01

    This study seeks to understand the role and impact of different types of organizational justice and multi-level identification on employees’ discretionary behavior. At the workplace, requirements of a job are typically defined by the role one is performing. Extra role behavior is understood as that part of employee’s discretionary contribution, which is not driven by explicit job description or rewarding structure, but still benefits the organization. Social Identity is considered to be ...

  20. Influence of ownership type on role orientation, role affinity, and role conflict among community pharmacy managers and owners in Canada.

    Science.gov (United States)

    Perepelkin, Jason; Dobson, Roy Thomas

    2010-12-01

    Ownership of community pharmacies is increasingly being controlled by a relatively small number of corporate entities. The influence of this ownership type should not be ignored, because ownership has the ability to impact pharmacy practice. To examine the relationship between ownership type and community pharmacy managers with regard to role orientation, role affinity, and role conflict. This study consisted of a cross-sectional survey of community pharmacy managers in Canada by means of a self-administered postal questionnaire sent to a stratified sample of community pharmacies. Statistical analysis consisted of exploratory factor analysis with reliability testing on identified constructs. Frequencies, 1-way analyses of variance, and Scheffe post hoc tests were used to determine significant differences among groups, including ownership structure, on each of the constructs. A total of 646 completed questionnaires were received (32.9% response rate). Most of the respondents were males (60.8%), with slightly less than half of the respondents identifying their practice type as an independent pharmacy (44.6%). There were 5 multi-item scale constructs (professional orientation, business orientation, professional affinity, business affinity, and role conflict) arising from the data, which were analyzed against the pharmacy ownership structure (independent, franchise, corporate) independent variable. Analysis revealed significant differences for 3 of the 5 constructs; however, no differences were seen regarding the 2 professionally focused constructs. Community pharmacy managers/owners are generally oriented to their professional role; however, those working in a corporate pharmacy environment are less oriented to their business role when compared with those working in an independent or franchise pharmacy environment. Further research is needed to identify different practice cultures that may exist in various practice settings and the extent to which these cultures

  1. Role conflict, role ambiguity and job satisfaction: Perceptions of the Brazilian controllers

    Directory of Open Access Journals (Sweden)

    Marilu Nuñez Palomino

    2016-06-01

    Full Text Available ABSTRACT From early times to the present, accounting literature has recorded several situations involving role conflict and ambiguity that cause tension among controllers. The theoretical framework was comprised of the seminal work on Role Theory by Katz and Kahn (1970, and empirical evidence regarding the evolution of the role of controllers in the enterprises. In this study, we used the structural equations technique, which allowed for non-rejection of the two study hypotheses, thus providing evidence that role conflict and ambiguity adversely affect job satisfaction among Brazilian controllers. The sample was comprised of 114 controllers. An electronic questionnaire was used to collect the data, allowing information about the respondents to be captured, along with their perceptions regarding levels of role conflict and ambiguity and job satisfaction. For this, the tools developed by Rizzo, House, and Lirtzman (1970 were used, as well as the Job Satisfaction Index presented by Tarrant and Sabo (2010. The results indicated that Brazilian controllers perceive role conflict and role ambiguity while they perform their duties. Job satisfaction of the controllers isaffected more strongly by role ambiguity than by role conflict. However, despite perceiving these two tensions, executives are moderately satisfied with their current working conditions.

  2. Semantic role labeling for protein transport predicates

    Directory of Open Access Journals (Sweden)

    Martin James H

    2008-06-01

    Full Text Available Abstract Background Automatic semantic role labeling (SRL is a natural language processing (NLP technique that maps sentences to semantic representations. This technique has been widely studied in the recent years, but mostly with data in newswire domains. Here, we report on a SRL model for identifying the semantic roles of biomedical predicates describing protein transport in GeneRIFs – manually curated sentences focusing on gene functions. To avoid the computational cost of syntactic parsing, and because the boundaries of our protein transport roles often did not match up with syntactic phrase boundaries, we approached this problem with a word-chunking paradigm and trained support vector machine classifiers to classify words as being at the beginning, inside or outside of a protein transport role. Results We collected a set of 837 GeneRIFs describing movements of proteins between cellular components, whose predicates were annotated for the semantic roles AGENT, PATIENT, ORIGIN and DESTINATION. We trained these models with the features of previous word-chunking models, features adapted from phrase-chunking models, and features derived from an analysis of our data. Our models were able to label protein transport semantic roles with 87.6% precision and 79.0% recall when using manually annotated protein boundaries, and 87.0% precision and 74.5% recall when using automatically identified ones. Conclusion We successfully adapted the word-chunking classification paradigm to semantic role labeling, applying it to a new domain with predicates completely absent from any previous studies. By combining the traditional word and phrasal role labeling features with biomedical features like protein boundaries and MEDPOST part of speech tags, we were able to address the challenges posed by the new domain data and subsequently build robust models that achieved F-measures as high as 83.1. This system for extracting protein transport information from Gene

  3. Antagonistic neural networks underlying differentiated leadership roles.

    Science.gov (United States)

    Boyatzis, Richard E; Rochford, Kylie; Jack, Anthony I

    2014-01-01

    The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950s. Recent research in neuroscience suggests that the division between task-oriented and socio-emotional-oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks - the task-positive network (TPN) and the default mode network (DMN). Neural activity in TPN tends to inhibit activity in the DMN, and vice versa. The TPN is important for problem solving, focusing of attention, making decisions, and control of action. The DMN plays a central role in emotional self-awareness, social cognition, and ethical decision making. It is also strongly linked to creativity and openness to new ideas. Because activation of the TPN tends to suppress activity in the DMN, an over-emphasis on task-oriented leadership may prove deleterious to social and emotional aspects of leadership. Similarly, an overemphasis on the DMN would result in difficulty focusing attention, making decisions, and solving known problems. In this paper, we will review major streams of theory and research on leadership roles in the context of recent findings from neuroscience and psychology. We conclude by suggesting that emerging research challenges the assumption that role differentiation is both natural and necessary, in particular when openness to new ideas, people, emotions, and ethical concerns are important to success.

  4. Defining the doula's role: fostering relational autonomy.

    Science.gov (United States)

    Meadow, Sandra L

    2015-12-01

    Training organizations as well as academic and popular literature provide ambiguous or ethically contentious characterizations of the role of the birth doula, a non-clinical role assisting women in pregnancy and birth with information and physical and emotional support. Doulas have been criticized for attempting to impose their own agendas on their clients and for interfering with the relationship between women and their medical caregivers. To develop a theoretically grounded model of the birth doula's role to guide constructive practice and refute some training organizations' and doulas' adoption of an active 'advocacy' role with clients that can lead to inappropriate practices. Apply the theoretical framework of relational autonomy to the components of the work that doulas perform with their clients. The conceptual framework of relational autonomy recognizes the social context in which women make choices about their care in pregnancy and birth, instead of assuming that autonomy is exercised in isolation. To support this understanding of autonomy, a relational model emphasizes women's skills development, self-confidence and recognition of the social context for decisions. Highlighting these aspects of exercising autonomy reduces the potential for the doula to seek to influence her client. The doula's role is reframed as one of facilitating patient engagement and shared decision-making. © 2014 John Wiley & Sons Ltd.

  5. Emerging roles of basophils in allergic inflammation

    Directory of Open Access Journals (Sweden)

    Kensuke Miyake

    2017-07-01

    Full Text Available Basophils have long been neglected in immunological studies because they were regarded as only minor relatives of mast cells. However, recent advances in analytical tools for basophils have clarified the non-redundant roles of basophils in allergic inflammation. Basophils play crucial roles in both IgE-dependent and -independent allergic inflammation, through their migration to the site of inflammation and secretion of various mediators, including cytokines, chemokines, and proteases. Basophils are known to produce large amounts of IL-4 in response to various stimuli. Basophil-derived IL-4 has recently been shown to play versatile roles in allergic inflammation by acting on various cell types, including macrophages, innate lymphoid cells, fibroblasts, and endothelial cells. Basophil-derived serine proteases are also crucial for the aggravation of allergic inflammation. Moreover, recent reports suggest the roles of basophils in modulating adaptive immune responses, particularly in the induction of Th2 differentiation and enhancement of humoral memory responses. In this review, we will discuss recent advances in understanding the roles of basophils in allergic inflammation.

  6. Antagonistic Neural Networks Underlying Differentiated Leadership Roles

    Directory of Open Access Journals (Sweden)

    Richard Eleftherios Boyatzis

    2014-03-01

    Full Text Available The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950’s. Recent research in neuroscience suggests that the division between task oriented and socio-emotional oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks -- the Task Positive Network (TPN and the Default Mode Network (DMN. Neural activity in TPN tends to inhibit activity in the DMN, and vice versa. The TPN is important for problem solving, focusing of attention, making decisions, and control of action. The DMN plays a central role in emotional self-awareness, social cognition, and ethical decision making. It is also strongly linked to creativity and openness to new ideas. Because activation of the TPN tends to suppress activity in the DMN, an over-emphasis on task oriented leadership may prove deleterious to social and emotional aspects of leadership. Similarly, an overemphasis on the DMN would result in difficulty focusing attention, making decisions and solving known problems. In this paper, we will review major streams of theory and research on leadership roles in the context of recent findings from neuroscience and psychology. We conclude by suggesting that emerging research challenges the assumption that role differentiation is both natural and necessary, in particular when openness to new ideas, people, emotions, and ethical concerns are important to success.

  7. Antagonistic neural networks underlying differentiated leadership roles

    Science.gov (United States)

    Boyatzis, Richard E.; Rochford, Kylie; Jack, Anthony I.

    2014-01-01

    The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950s. Recent research in neuroscience suggests that the division between task-oriented and socio-emotional-oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks – the task-positive network (TPN) and the default mode network (DMN). Neural activity in TPN tends to inhibit activity in the DMN, and vice versa. The TPN is important for problem solving, focusing of attention, making decisions, and control of action. The DMN plays a central role in emotional self-awareness, social cognition, and ethical decision making. It is also strongly linked to creativity and openness to new ideas. Because activation of the TPN tends to suppress activity in the DMN, an over-emphasis on task-oriented leadership may prove deleterious to social and emotional aspects of leadership. Similarly, an overemphasis on the DMN would result in difficulty focusing attention, making decisions, and solving known problems. In this paper, we will review major streams of theory and research on leadership roles in the context of recent findings from neuroscience and psychology. We conclude by suggesting that emerging research challenges the assumption that role differentiation is both natural and necessary, in particular when openness to new ideas, people, emotions, and ethical concerns are important to success. PMID:24624074

  8. The role of women in family businesses

    Directory of Open Access Journals (Sweden)

    Jaka Vadnjal

    2010-11-01

    Full Text Available

    The role of women in family businesses is explored in the paper. Although recognised as generally very important players, the role of women is oft en defined as invisible in business decision-making, supportive in men’s traditional business domains and only rarely adequately recognised and rewarded. The paper explores possible differences in the views of men and women who manage small family firms. Their attitudes opposing the traditional business roles of women, different views on managerial, ownership and transition issues and possible gender discrimination are examined. The findings support the paradigm of a different, more feminine style of management, while signs of discrimination are not clearly revealed.

  9. The role of Probiotics in allergic diseases

    Directory of Open Access Journals (Sweden)

    Michail Sonia

    2009-10-01

    Full Text Available Abstract Allergic disorders are very common in the pediatric age group. While the exact etiology is unclear, evidence is mounting to incriminate environmental factors and an aberrant gut microbiota with a shift of the Th1/Th2 balance towards a Th2 response. Probiotics have been shown to modulate the immune system back to a Th1 response. Several in vitro studies suggest a role for probiotics in treating allergic disorders. Human trials demonstrate a limited benefit for the use of probiotics in atopic dermatitis in a preventive as well as a therapeutic capacity. Data supporting their use in allergic rhinitis are less robust. Currently, there is no role for probiotic therapy in the treatment of bronchial asthma. Future studies will be critical in determining the exact role of probiotics in allergic disorders.

  10. Role of dental expert in forensic odontology.

    Science.gov (United States)

    Verma, Anoop K; Kumar, Sachil; Rathore, Shiuli; Pandey, Abhishek

    2014-01-01

    Forensic dentistry has become an integral part of forensic science over the past 100 years that utilizes dental or oro-facial findings to serve the judicial system. This has been due to the dedication of people like Gustafson's, Keiser-Nielson, and Suzuki for this field. They established the essential role which forensic dentistry plays mainly in the identification of human remains. The tooth has been used as weapons and under certain circumstances, may leave information about the identity of the biter. Dental professionals have a major role to play in keeping accurate dental records and providing all necessary information so that legal authorities may recognize mal practice, negligence, fraud or abuse, and identity of unknown individuals. This paper will try to summarize the various roles of dental experts in forensic medicine.

  11. RELATION OF COACHING BEHAVIOR AND ROLE AMBIGUITY

    Directory of Open Access Journals (Sweden)

    Karamousalidis G.

    2010-08-01

    Full Text Available The purpose of this research was to investigate the relationship between coaching behavior and role ambiguity in defensive responsibilities using interdependent Greek sport teams. Athlete perceptions of role ambiguity (defense were assessed using a questionnaire developed by Beauchamp, Bray, Eys and Carron (2002 andcoaching behavior was assessed using the Coaching Behavior Questionnaire, (Williams, et. al., 2003. The sample consisted of 409 athletes of basketball, volleyball, handball and soccer. Confirmatory factor analysis provided the construct validity of the questionnaires and correlations among the scales confirmed construct validity. The implications of the results are discussed and future research should continue to investigate the multidimensional models of both coaching behavior and role ambiguity in sport settings.

  12. The Role of Communications in Coaching

    Directory of Open Access Journals (Sweden)

    Urszula Dziewulska

    2008-12-01

    Full Text Available The aim of this article is presenting one of the development tools, that is coaching. There were bringing up the basic definitions and described coaching stages, styles and techniques used in conversation by trainers in the article. In the article were presented the main roles that should be kept by coach as well as the barriers that he can meets during his work. There were indicated the crucial role of interpersonal communication in conversation between two persons in that case coach and pupil and also the most popular mistakes. There were given also the roles of listening that are the most important in keeping positive vocational and private contacts with others. Moreover in the article prescribed “good trainer” features and the sense of such skills as building the positive relations with pupil, listening, using the intuition, asking and giving the feedback.

  13. Role of T lymphocytes in hypertension.

    Science.gov (United States)

    Zhang, Jiandong; Crowley, Steven D

    2015-04-01

    Accumulating evidence indicates that the immune system plays a critical role in the pathogenesis of cardiovascular diseases including hypertension. Mice lacking T lymphocytes are resistant to blood pressure elevation, suggesting a key contribution of T lymphocytes to hypertension. However, the individual T cell subsets, including CD8(+), Th1, Th17, and T regulatory T cells have shown widely discrepant effects on blood pressure and target organ damage in this disorder. Moreover, the activation state of a T lymphocyte population exerts considerable influence over its role in hypertension. In turn, activated T cells regulate blood pressure through the elaboration of reactive oxygen species and vasoactive cytokines, altering the inflammatory milieu in the vascular wall and the kidney. Recent GWAS studies similarly point to a role for T lymphocytes in human hypertension. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Role of honey in modern medicine

    Directory of Open Access Journals (Sweden)

    Sultan Ayoub Meo

    2017-07-01

    Full Text Available Use of honey has a very long history. Honey has been used since ancient time due to its nutritional and therapeutic values. There had been varied ways of consumption honey including its use as a sweetener and flavoring agent. Honey is produced all over the world. The most important nutriment of honey is carbohydrates present in the form of monosaccharides, fructose and glucose. Honey plays an important role as an antioxidant, anti-inflammatory, anti-bacterial agent and augments the adherence of skin grafts and wound healing process. The role of honey has been acknowledged in the scientific literature and there is convincing evidence in support of its antioxidant and antibacterial nature, cough prevention, fertility and wound healing properties. However, its use has been controversially discussed and has not been well accepted in the modern medicine. The aim of this review was explore and highlight the role of honey in modern medicine.

  15. Role of angiogenesis in chronic lymphocytic leukemia.

    Science.gov (United States)

    Letilovic, Tomislav; Vrhovac, Radovan; Verstovsek, Srdan; Jaksic, Branimir; Ferrajoli, Alessandra

    2006-09-01

    Angiogenesis is a physiologic process of new blood vessels formation mediated by various cytokines called angiogenic and angiostatic factors. Although its potential pathophysiologic role in solid tumors has been extensively studied for more than 3 decades, enhancement of angiogenesis in chronic lymphocytic leukemia (CLL) and other malignant hematological disorders has been recognized more recently. An increased level of angiogenesis has been documented by various experimental methods both in bone marrow and lymph nodes of patients with CLL. Although the role of angiogenesis in the pathophysiology of this disease remains to be fully elucidated, experimental data suggest that several angiogenic factors play a role in the disease progression. Biologic markers of angiogenesis were also shown to be of prognostic relevance in CLL. The current findings provide the rationale for investigating antiangiogenic agents in CLL. In the current review angiogenesis in CLL is discussed and its potential diagnostic and therapeutic applications.

  16. Alcohol metabolism: role in toxicity and carcinogenesis.

    Science.gov (United States)

    Badger, Thomas M; Ronis, Martin J J; Seitz, Helmut K; Albano, Emanuele; Ingelman-Sundberg, Magnus; Lieber, Charles S

    2003-02-01

    This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz.

  17. THE ROLES OF MOSQUE LIBRARIES THROUGH HISTORY

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    Nurdin Laugu

    2007-03-01

    Full Text Available Since the formation of the Islamic society by prophet Muhammad, mosque libraries fulfilled several important roles that deserve scholarly attention. Therefore, this article elicits the significance of these various roles within Muslim societies through Islamic history. Until present day, almost all mosque libraries provide a variety of collections, concerning both religious and non-religious issues, such as social science and education. In line with these roles, this paper presents different examples of mosque libraries that, through history, contributed significantly to the development of Islamic civilization, like the library of the al-Azhar mosque in Egypt, the Grand Mosque Library in Cordova, etc. In addition, several aspects determining the (insignificance of mosque libraries through history, such as library management and factors contributing to the stagnation of mosque libraries, are investigated.

  18. MOVING EDUCATIONAL ROLE-PLAY BEYOND ENTERTAINMENT

    Directory of Open Access Journals (Sweden)

    Thomas Duus Henriksen

    2010-11-01

    Full Text Available Educational role-play has long proved an effective tool for consultants trying to develop the skills that employees are using for performing certain job functions. However, while educational role-play often is presented as an entertaining means for learning, such insistence on making learning games more gamish seems to have an inhibiting effect on designing and thinking games beyond mere skill acquisition. By emphasising the role-play based process as a conflictual negotiation between distinctive categories of knowledge, this paper presents the explorative application of knowledge, while framing the facilitation of reflective processes as the key for transcending knowledge from the game’s context to that of the participants. While pointing towards the compatibility issues between current conceptions of learning games and the facilitation of reflective processes, the paper emphasises the need for thinking the learning game as a part of a didactic design, rather than something beneficial in itself.

  19. The role of nicotine in tobacco use.

    Science.gov (United States)

    Robinson, J H; Pritchard, W S

    1992-01-01

    The 1988 US Surgeon General's Report titled "Nicotine Addiction", is cited frequently in the literature as having established the "fact" that nicotine derived from cigarette smoke is addictive in the same sense as "classic" addicting drugs such as heroin and cocaine. This manuscripts critically evaluates key research findings used in support of this claim and identifies shortcomings in the data that seriously question the logic of labeling nicotine as "addictive". In addition, the manuscript argues that the role of nicotine in tobacco use is not like the role of cocaine in coca leaf use as argued by the 1988 Surgeon General's Report, but is, in fact, more like the role of caffeine in coffee drinking as concluded in the 1964 US Surgeon General's Report.

  20. The pharmacist's role in promoting preconception health.

    Science.gov (United States)

    El-Ibiary, Shareen Y; Raney, Erin C; Moos, Merry-K

    2014-01-01

    To review the pharmacist's role in preconception health. PubMed search using the terms preconception, immunizations, epilepsy, diabetes, depression, tobacco, asthma, hypertension, anticoagulation, pharmacist, pregnancy, and current national guidelines. Preconception health has become recognized as an important public health focus to improve pregnancy outcomes. Pharmacists have a unique role as accessible health care providers to optimize preconception health by screening women for tobacco use, appropriate immunizations, and current medication use. Counseling patients on preconception risk factors and adequate folic acid supplementation as well as providing recommendations for safe and effective management of chronic conditions are also critical and within the scope of practice for pharmacists. Pharmacists play an important role in medication screening, chronic disease state management, and preconception planning to aid women in preparing for healthy pregnancies.

  1. Roles and Self-Reconfigurable Robots

    DEFF Research Database (Denmark)

    Dvinge, Nicolai; Schultz, Ulrik Pagh; Christensen, David Johan

    2007-01-01

    A self-reconfigurable robot is a robotic device that can change its own shape. Self-reconfigurable robots are commonly built from multiple identical modules that can manipulate each other to change the shape of the robot. The robot can also perform tasks such as locomotion without changing shape....... Programming a modular, self-reconfigurable robot is however a complicated task: the robot is essentially a real-time, distributed embedded system, where control and communication paths often are tightly coupled to the current physical configuration of the robot. To facilitate the task of programming modular......, self-reconfigurable robots, we have developed a declarative, role-based language that allows the programmer to associate roles and behavior to structural elements in a modular robot. Based on the role declarations, a dedicated middleware for high-level distributed communication is generated...

  2. Role of dental expert in forensic odontology

    Science.gov (United States)

    Verma, Anoop K.; Kumar, Sachil; Rathore, Shiuli; Pandey, Abhishek

    2014-01-01

    Forensic dentistry has become an integral part of forensic science over the past 100 years that utilizes dental or oro-facial findings to serve the judicial system. This has been due to the dedication of people like Gustafson's, Keiser-Nielson, and Suzuki for this field. They established the essential role which forensic dentistry plays mainly in the identification of human remains. The tooth has been used as weapons and under certain circumstances, may leave information about the identity of the biter. Dental professionals have a major role to play in keeping accurate dental records and providing all necessary information so that legal authorities may recognize mal practice, negligence, fraud or abuse, and identity of unknown individuals. This paper will try to summarize the various roles of dental experts in forensic medicine. PMID:25298709

  3. Situational Awareness of Network System Roles (SANSR)

    Energy Technology Data Exchange (ETDEWEB)

    Huffer, Kelly M [ORNL; Reed, Joel W [ORNL

    2017-01-01

    In a large enterprise it is difficult for cyber security analysts to know what services and roles every machine on the network is performing (e.g., file server, domain name server, email server). Using network flow data, already collected by most enterprises, we developed a proof-of-concept tool that discovers the roles of a system using both clustering and categorization techniques. The tool's role information would allow cyber analysts to detect consequential changes in the network, initiate incident response plans, and optimize their security posture. The results of this proof-of-concept tool proved to be quite accurate on three real data sets. We will present the algorithms used in the tool, describe the results of preliminary testing, provide visualizations of the results, and discuss areas for future work. Without this kind of situational awareness, cyber analysts cannot quickly diagnose an attack or prioritize remedial actions.

  4. Information and Its Role in Nature

    CERN Document Server

    Roederer, Juan G

    2005-01-01

    Infromation and Its Role in Nature presents an in-depth interdisciplinary discussion of the concept of information and its role in the control of natural processes. After a brief review of classical and quantum information theory, the author addresses numerous central questions, including: Is information reducible to the laws of physics and chemistry? Does the Universe, in its evolution, constantly generate new information? Or are information and information-processing exclusive attributes of living systems, related to the very definition of life? If so, what is the role of information in classical and quantum physics? In what ways does information-processing in the human brain bring about self-consciousness? Accessible to graduate students and professionals from all scientific disciplines, this stimulating book will help to shed light on many controversial issues at the heart of modern science.

  5. The Principalship: Role Expectation and Leadership Style. Draft Outline.

    Science.gov (United States)

    Gould, E. N.

    This paper discusses role expectations of principals, including the importance of the principal role, pressures and difficulties associated with it, and the problem of conflicting role expectations. (Author/LD)

  6. The importance of role sending in the sensemaking of change agent roles.

    Science.gov (United States)

    Tucker, Danielle A; Hendy, Jane; Barlow, James

    2015-01-01

    The purpose of this paper is to investigate what happens when a lack of role-sending results in ambiguous change agent roles during a large scale organisational reconfiguration. The authors consider the role of sensemaking in resolving role ambiguity of middle manager change agents and the consequences of this for organisational restructuring. Data were collected from a case study analysis of significant organisational reconfiguration across a local National Health Service Trust in the UK. Data consists of 82 interviews, complemented by analysis of over 100 documents and field notes from 51 hours of observations collected over five phases covering a three year period before, during and after the reconfiguration. An inductive qualitative analysis revealed the sensemaking processes by which ambiguity in role definition was resolved. The data explains how change agents collectively make sense of a role in their own way, drawing on their own experiences and views as well as cues from other organisational members. The authors also identified the organisational outcomes which resulted from this freedom in sensemaking. This study demonstrates that by leaving too much flexibility in the definition of the role, agents developed their own sensemaking which was subsequently very difficult to manipulate. In creating new roles, management first needs to have a realistic vision of the task and roles that their agents will perform, and second, to communicate these expectations to both those responsible for recruiting these roles and to the agents themselves. Much of the focus in sensemaking research has been on the importance of change agents' sensemaking of the change but there has been little focus on how change agents sensemake their own role in the change.

  7. Medical student involvement in health policy roles

    Directory of Open Access Journals (Sweden)

    Malik B

    2017-11-01

    Full Text Available Bassit Malik,1 Utkarsh Ojha,1 Hassan Khan,1 Farzana Begum,2 Harun Khan,1 Qasim Malik3 1School of Medicine, Imperial College London, London, UK; 2Barts and the London School of Medicine and Dentistry, London, UK; 3Heart of England NHS Foundation Trust, Birmingham, UK Objectives: A teaching curriculum in health policy may be well established in medical school; however, an emphasis on applying taught principles via participation in health policy roles is less defined. We undertook a study to explore medical student participation in health policy roles.Design and setting: An anonymous online survey via convenience sampling was conducted in the UK.Participants: A total of 112 students from six medical schools participated in the study.Outcome measures: The outcome measures were as follows: medical students’ beliefs about their current knowledge of health policy and their desire to learn more; their current, past and future involvement in a health policy role, and perceived barriers to involvement.Results: Forty-seven percent of participants reported previous teaching on health policy, with the majority scoring themselves 2 out of 5 for knowledge about the topic (38%. Seventy-seven percent of participants expressed a desire to be taught health policy while 73% agreed with compulsory teaching. Ninety-six percent of participants reported no current or previous activity in a health policy role, with 61% willing to undertake a role in the future. The three main barriers to student involvement were: a lack of knowledge about health policy (57%, an unawareness of opportunities available (56%, and a lack of time (43%.Conclusion: In addition to already established teaching programs within medical school, implementation of community-based experiences could improve knowledge of health policy, while providing an opportunity for students to gain experience in health policy committee roles. Keywords: medical curriculum, policy committee, service learning

  8. Role of Noninvasive Hemoglobin Monitoring in Trauma

    Science.gov (United States)

    2015-03-25

    AFRL-SA-WP-SR-2015-0002 Role of Noninvasive Hemoglobin Monitoring in Trauma Betty J. Tsuei, MD; Dennis J. Hanseman, PhD...August 2012 – August 2013 4. TITLE AND SUBTITLE Role of Noninvasive Hemoglobin Monitoring in Trauma 5a. CONTRACT NUMBER FA8650-12-2-6B14 5b...measurement of hemoglobin (Hgb) by standard laboratory complete blood count. Point-of-care testing (i.e., iSTAT®) can be a rapid method of evaluating

  9. Can role models boost entrepreneurial attitudes?

    Science.gov (United States)

    Fellnhofer, Katharina; Puumalainen, Kaisu

    2017-01-01

    This multi-country study used role models to boost perceptions of entrepreneurial feasibility and desirability. The results of a structural equation model based on a sample comprising 426 individuals who were primarily from Austria, Finland and Greece revealed a significant positive influence on perceived entrepreneurial desirability and feasibility. These findings support the argument for embedding entrepreneurial role models in entrepreneurship education courses to promote entrepreneurial activities. This direction is not only relevant for the academic community but also essential for nascent entrepreneurs, policymakers and society at large.

  10. Comparing teacher roles in Denmark and England

    DEFF Research Database (Denmark)

    Kelly, Peter; Dorf, Hans; Pratt, Nick

    2014-01-01

    was the ease with which competent English teachers moved between roles. The English teachers observed adopted roles consistent with a wider techno-rationalist discourse. There was a greater subject emphasis by Danish teachers, whose work was set predominantly within a democratic humanist discourse, whilst...... the English teachers placed a greater emphasis on applied skills.......This article reports the findings of a comparative study of teaching in Denmark and England. Its broader aim is to help develop an approach for comparing pedagogy. Lesson observations and interviews identified the range of goals towards which teachers in each country worked and the actions...

  11. Central venous catheters: the role of radiology

    Energy Technology Data Exchange (ETDEWEB)

    Tan, P.L. [Department of Radiology, John Radcliffe Hospital, Oxford (United Kingdom)]. E-mail: pecklingtan@hotmail.com; Gibson, M. [Department of Radiology, Royal Berkshire Hospital, Reading, Berkshire (United Kingdom)

    2006-01-15

    The insertion and management of long-term venous catheters have long been the province of anaesthetists, intensive care physicians and surgeons. Radiologists are taking an increasing role in the insertion of central venous catheters (CVCs) because of their familiarity with the imaging equipment and their ability to manipulate catheters and guide-wires. The radiological management of the complications of CVCs has also expanded as a result. This article reviews the role of radiology in central venous access, covering the detection and management of their complications.

  12. Role of ascorbic acid in photosynthesis.

    Science.gov (United States)

    Ivanov, B N

    2014-03-01

    Experimental data concerning the role of ascorbic acid in both the maintenance of photosynthesis and in the protection of the photosynthetic apparatus against reactive oxygen species and photoinhibition are reviewed. The function of ascorbic acid as an electron donor in the "Krasnovsky reaction", as well as its physiological role as a donor to components of the photosynthetic electron transport chain, which was first studied by A. A. Krasnovsky in the 1980s, is discussed. Data on the content and transport of ascorbic acid in plant cells and chloroplasts are presented.

  13. Live action role-playing games

    DEFF Research Database (Denmark)

    Tychsen, Anders; Hitchens, Michael; Brolund, Thea

    2006-01-01

    Live action role-playing games share a range of characteristics with massively multi-player online games (MMOGs). Because these games have existed for more than 20 years, players of these games have a substantial amount of experience in handling issues pertinent to MMOGs. Survey and review of live...... action role-playing games, whose participant count can be in the thousands, reveal that features such as size, theme, game master-to-player ratio, and others interact to form complex systems that require several different groups of control tools to manage. The way that these games are managed offers...

  14. Role of Uncoupling Proteins in Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Valle, Adamo; Oliver, Jordi; Roca, Pilar, E-mail: pilar.roca@uib.es [Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d' Investigació en Ciències de la Salut, Universitat de les Illes Balears/Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Illes Balears (Spain)

    2010-04-16

    Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance.

  15. Psychiatric residency, role models, and leadership.

    Science.gov (United States)

    Sherwood, E; Greenblatt, M; Pasnau, R O

    1986-06-01

    Two hundred fifty ex-fellowship psychiatrists answered a questionnaire on their administrative and other professional experiences during and after residency as part of a study to determine the relationship between psychiatric training experiences and interest in administration. A large majority of subjects had had role models during training. The subjects' interest in administration had grown significantly during residency in the direction of their role models' interest. Postresidency interest in administration was significantly correlated with supervision by a psychiatrist administrator and with the number of hours subjects spent on administrative work.

  16. Role of achara rasayana in chittodvega.

    Science.gov (United States)

    Babu, G; Bhuyan, G C; Prasad, G P; Anitha, S

    2007-04-01

    Ayuveda "the science of life" deals with various dimensions of human being. In this age old science, psychological factors have been given equal importance as physiological factors in the etiology of various diseases. Though there are so many rejuvenation therapies, Achara Rasayana is mainly advocated for psychosomatic disorders. Chittodvega (anxiety neurosis) is one among those psychological diseases in which, the code of conduct (Achara Rasayana) plays an important role in both etiology as well as treatment. Here an attempt has been taken to clarify the role of Achara Rasayana in the disease Chittodvega.

  17. Role of management devices in enacting strategy

    DEFF Research Database (Denmark)

    Harritz, Daniel

    2016-01-01

    Purpose - This study illustrates the role of management devices in enacting strategy and strategic decisions, resulting in the development of a Shared Service Centre (SSC) in a Danish municipality. It shows how devices interact in defending, rejecting and reframing strategy, leading to the closure...... role of management devices. Practical implications - The findings facilitate a deeper understanding of factors triggering strategic development in the public sector. Also, it identifies aspects leading to failures by investigating how different devices allow local actors to stay connected and affect...

  18. Psychology's role in mathematics and science education.

    Science.gov (United States)

    Newcombe, Nora S; Ambady, Nalini; Eccles, Jacquelynne; Gomez, Louis; Klahr, David; Linn, Marcia; Miller, Kevin; Mix, Kelly

    2009-09-01

    Improving mathematics and science education in the United States has been a matter of national concern for over half a century. Psychology has a vital role to play in this enterprise. In this article, the authors review the kinds of contributions that psychology can make in four areas: (a) early understanding of mathematics, (b) understanding of science, (c) social and motivational aspects of involvement in mathematics and science, and (d) assessment of learning in mathematics and science. They also examine challenges to psychology's playing a central and constructive role and make recommendations for overcoming those challenges.

  19. Role of music therapy in integrative oncology.

    Science.gov (United States)

    Magill, Lucanne

    2006-01-01

    Music therapy is an evidence-based complementary therapy that enhances quality of life in cancer patients and their caregivers. The role of music therapy in integrative oncology encompassed care and treatment of patients and family members , ongoing collaboration with the health care team, and the provision of music therapy services that may benefit the cancer center community. Clinical work includes ongoing assessment and the implementation of specific music therapy techniques aimed at reducing challenging symptoms and enhancing overall well-being and quality of life. This article outlines music therapy methods and the role that the music therapist has in integrative oncology programs.

  20. The Roles of Conference Papers in IS

    DEFF Research Database (Denmark)

    Lanamäki, Arto; Persson, John Stouby

    2016-01-01

    Information Systems (IS) research has both a journal-oriented publication culture and a rich plethora of conferences. It is unclear why IS researchers even bother with conference publishing given the high focus on journals. Against this backdrop, the purpose of this paper is to increase our...... understanding of conference papers in IS and the role they play for the authoring researchers. We present the first analysis of the papers published during the first six years (2010-2015) in the Scandinavian Conference on Information Systems (SCIS). We conducted interviews with ten SCIS authors. Following...... the role of conference papers in research....

  1. Role of dentist in person identification

    Directory of Open Access Journals (Sweden)

    Chandra Shekar B

    2009-01-01

    Full Text Available To reinforce awareness among dentists about their role in person identification and the importance of maintaining dental records of all their patients. The article reviews basic procedures of dental identification and some cases where dental identification played a key role in eventual identification of the person. Forensic odontology is an integral part of forensic sciences. Forensic dental identifications, especially in times of mass disasters, depend mainly on the availability of ante mortem dental records. It is the social responsibility of each and every dentist to maintain dental records of their patients for the noble cause of identification in the event of mass disaster.

  2. Can role models boost entrepreneurial attitudes?

    Science.gov (United States)

    Fellnhofer, Katharina; Puumalainen, Kaisu

    2017-01-01

    This multi-country study used role models to boost perceptions of entrepreneurial feasibility and desirability. The results of a structural equation model based on a sample comprising 426 individuals who were primarily from Austria, Finland and Greece revealed a significant positive influence on perceived entrepreneurial desirability and feasibility. These findings support the argument for embedding entrepreneurial role models in entrepreneurship education courses to promote entrepreneurial activities. This direction is not only relevant for the academic community but also essential for nascent entrepreneurs, policymakers and society at large. PMID:28458611

  3. Role of Uncoupling Proteins in Cancer

    Directory of Open Access Journals (Sweden)

    Adamo Valle

    2010-04-01

    Full Text Available Uncoupling proteins (UCPs are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS. Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance.

  4. Sex Role Attitudes and Fear of Success as Correlates of Sex Role Behavior

    Science.gov (United States)

    Williams, Dana; King, Michael

    1976-01-01

    Relationships of sex role attitudes and fear of success with college women's grade point average, academic major, and future career and marriage plans are examined. Sex role attitudes were related to major, career and marriage plans. Fear of success was not related to grade point average, major, career or marriage plans. (Author)

  5. Sex Role Stereotyping and Sex Role Norms: A Comparison of Elementary and College Age Students.

    Science.gov (United States)

    Hensley, Karma K.; Borges, Marilyn A.

    1981-01-01

    Examined sex-role stereotyping and its relation to sex-role norms. Results show children stereotyped in behavioral descriptions and occupational choices more than did college students. Children whose mothers were employed were more stereotyped in occupational choices. College students evidenced a very low rate of stereotyping in behavioral…

  6. Defining the Role of the Pharmacy Technician and Identifying Their Future Role in Medicines Optimisation.

    Science.gov (United States)

    Boughen, Melanie; Sutton, Jane; Fenn, Tess; Wright, David

    2017-07-15

    Traditionally, pharmacy technicians have worked alongside pharmacists in community and hospital pharmacy. Changes within pharmacy provide opportunity for role expansion and with no apparent career pathway, there is a need to define the current pharmacy technician role and role in medicines optimisation. To capture the current roles of pharmacy technicians and identify how their future role will contribute to medicines optimisation. Following ethical approval and piloting, an online survey to ascertain pharmacy technicians' views about their roles was undertaken. Recruitment took place in collaboration with the Association of Pharmacy Technicians UK. Data were exported to SPSS, data screened and descriptive statistics produced. Free text responses were analysed and tasks collated into categories reflecting the type of work involved in each task. Responses received were 393 (28%, n = 1380). Results were organised into five groups: i.e., hospital, community, primary care, General Practitioner (GP) practice and other (which included HM Prison Service). Thirty tasks were reported as commonly undertaken in three or more settings and 206 (84.7%, n = 243) pharmacy technicians reported they would like to expand their role. Tasks core to hospital and community pharmacy should be considered for inclusion to initial education standards to reflect current practice. Post qualification, pharmacy technicians indicate a significant desire to expand clinically and managerially allowing pharmacists more time in patient-facing/clinical roles.

  7. Aggression in Teachers is Related to Role Conflict and Role Ambiguity as Occupational Stress.

    Science.gov (United States)

    Kanchika, Masaru; Iwasaki, Shinichi; Konish, Akihito; Deguchi, Yasuhiko; Kobayashi, Yumi; Nakada, Akihiro; Inoue, Koki

    2015-12-01

    Aggression in the workplace is increasingly recognized as a serious problem, but there are few studies about worker aggression toward outsiders in the workplace. We investigated the association between aggression and occupational stress among teachers. This was a cross-sectional study of 1583 teachers, principals, and vice-principals. Aggression was measured using the Japanese version of the Buss-Perry Aggression Questionnaire (BAQ). The survey respondents were classified into tertiles according to the BAQ score. The high BAQ group was defined as the upper tertile for the BAQ total score (BAQ total score 625). Occupational stress was measured using the Japanese version of the Generic Job Stress Questionnaire. Comparisons among the groups were performed using multiple logistic regression analysis. Of the 1583 respondents, 488 were included in the high BAQ group. After adjusting for demographic and occupational variables, high role conflict and role ambiguity were significantly associated with belonging to the high BAQ group. In subscales of the BAQ, high role conflict and role ambiguity related to high levels of hostility, and physical aggression. Occupational stress such as role conflict and role ambiguity was associated with aggression among teachers. It is necessary to reduce problems which relates to role conflict and role ambiguity for preventing teachers' aggression.

  8. Perceived Role Legitimacy and Role Importance of Australian School Staff in Addressing Student Cannabis Use

    Science.gov (United States)

    Gates, Peter J.; Norberg, Melissa M.; Dillon, Paul; Manocha, Ramesh

    2013-01-01

    The high prevalence of cannabis use by Australian secondary school students makes schools an ideal setting for the delivery of substance use prevention programs. Although efficacious school-based cannabis prevention programs exist, there is scant research investigating the perceived role legitimacy and role importance of school staff. As such,…

  9. Role Resources and Work-Family Enrichment: The Role of Work Engagement

    Science.gov (United States)

    Siu, Oi-ling; Lu, Jia-fang; Brough, Paula; Lu, Chang-qin; Bakker, Arnold B.; Kalliath, Thomas; O'Driscoll, Michael; Phillips, David R.; Chen, Wei-qing; Lo, Danny; Sit, Cindy; Shi, Kan

    2010-01-01

    This article proposes a theoretical model of work-family enrichment and tests the mediating role of work engagement. The inclusion of work engagement extends prior research on work-family interface, and allows for examination of the effects of role resources (job resources, family support) on work-family enrichment. A two-wave survey was conducted…

  10. Collaboration using roles. [in computer network security

    Science.gov (United States)

    Bishop, Matt

    1990-01-01

    Segregation of roles into alternative accounts is a model which provides not only the ability to collaborate but also enables accurate accounting of resources consumed by collaborative projects, protects the resources and objects of such a project, and does not introduce new security vulnerabilities. The implementation presented here does not require users to remember additional passwords and provides a very simple consistent interface.

  11. Role of Outer Membrane Vesicles of Bacteria

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 8. Role of Outer Membrance Vesicles of Bacteria. M V Jagannadham M K Chattopadhyay. General Article Volume 20 Issue 8 ... Keywords. Outer membrane ves ic les (OMVs); secretion; communication; virulence; antibiotic resistance; vaccines.

  12. The many roles of vision during walking

    NARCIS (Netherlands)

    Logan, David; Kiemel, Tim; Dominici, Nadia; Cappellini, Germana; Ivanenko, Yuri; Lacquaniti, Francesco; Jeka, John J

    2010-01-01

    Vision can improve bipedal upright stability during standing and locomotion. However, during locomotion, vision supports additional behaviors such as gait cycle modulation, navigation, and obstacle avoidance. Here, we investigate how the multiple roles of vision are reflected in the dynamics of

  13. The Role of Entrepreneurial Competencies in Promoting ...

    African Journals Online (AJOL)

    This study examined the role of entrepreneurial competencies in promoting entrepreneurship in Nigeria using selected practicing entrepreneurs in Anambra State as case study. The study adopted descriptive survey design. Eight hundred and fifty-one (851) business owners and managers within the defined category were ...

  14. Sport Nutritionist: A New Sport Education Role

    Science.gov (United States)

    Martin, Matthew R.; Zimmerman, Ryan; Ciotto, Carol

    2015-01-01

    Considering the challenges associated with adolescent obesity and the need for innovative and meaningful physical education curricula, the authors of this article decided to create a new sport education role to help students learn about the fundamental nutritional concepts and practices that contribute to a healthy and active lifestyle. The new…

  15. Role of the Military, Unit III.

    Science.gov (United States)

    Robinson, Terry

    This unit on the role of the military in Wyoming history provides activities which focus on the system of forts which began in 1849, Indian conflicts, World War II, and the Army and Air National Guard. Student activities include illustrating various battles, locating major Wyoming forts on a map, field trips to F.E. Warren Air Force Base and Fort…

  16. The role of the African Union

    African Journals Online (AJOL)

    ian

    The issue of regionalism is today present throughout the international system, and regional organisations are widely considered to play an important role in relation to regional and sub-regional security. With the sub-regional organisations increasingly overburdened, such regional organisations have emerged as one ...

  17. Quantifying tasks and roles in insect societies

    African Journals Online (AJOL)

    1991-05-15

    May 15, 1991 ... pursues two themes to develop a rigorous methodology for their quantification: proposing guidelines for appropriate sampling methods and sample sizes; and a critical review of appropriate analytical techniques. These approaches are meant only to describe a colony's roles and tasks, serving as the basis ...

  18. Corporate Social Responsibility: what role for law?

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2006-01-01

    The article discusses the role that law plays for CSR in substance, action and reporting, including whether CSR functions as informal law. The theoretical point of departure is based in legal science. Through a discussion of various contexts of CSR in which law and legal standards feature, the ar...

  19. Child Participant Roles in Applied Linguistics Research

    Science.gov (United States)

    Pinter, Annamaria

    2014-01-01

    Children's status as research participants in applied linguistics has been largely overlooked even though unique methodological and ethical concerns arise in projects where children, rather than adults, are involved. This article examines the role of children as research participants in applied linguistics and discusses the limitations of…

  20. Stories of Innovation: Roles, Perspectives, and Players

    Science.gov (United States)

    Martens, Jon

    2014-01-01

    Purpose: This study aims to examine the roles of stories in the innovation process. Design/methodology/approach: An integrative literature review was used to identify and analyze studies that examined stories of innovation in various organizational settings. The conceptual framework of the review was based on three perspectives of organizational…

  1. The role of ICT in Education

    African Journals Online (AJOL)

    User

    increasingly important place that (ICTs) could receive in education. Since ICTs provide greater opportunity for students and teachers to adjust learning and teaching to individual needs, society is, forcing schools to give appropriate response to this technical innovation. Even though ICTs play significant roles in representing ...

  2. Lupus nephritis: role of antinucleosome autoantibodies

    NARCIS (Netherlands)

    Vlag, J. van der; Berden, J.H.M.

    2011-01-01

    The discovery of autoantigen clustering in blebs at the surface of apoptotic cells boosted research on the role of apoptosis in systemic lupus erythematosus (SLE) and led to the discovery of autoantigen modification during apoptosis. Normally, apoptotic cells are cleared efficiently and swiftly.

  3. The Negotiation of the Sick Role

    DEFF Research Database (Denmark)

    Mik-Meyer, Nanna; Roelsgaard Obling, Anne

    2012-01-01

    In encounters between general practitioners (GPs) and patients with medically unexplained symptoms (MUS), the negotiation of the sick role is a social process. In this process, GPs not only use traditional biomedical diagnostic tools but also rely on their own opinions and evaluations of a patient...

  4. Role of mast cells in cow metritis

    Directory of Open Access Journals (Sweden)

    Wang Guo-Qing

    2016-06-01

    Full Text Available Introduction: Bovine postpartum metritis causes great losses. Mast cell (MC-released mediators participate in uterine inflammation and immune response, but their role in postpartum metritis in cows has not been reported. This study investigated the effect of endometrial MC on the disorder.

  5. Role of mast cells in cow metritis

    OpenAIRE

    Wang Guo-Qing; Hou Jin-Long; Huang Huan-Yu; Yuan Chao-Wen

    2016-01-01

    Introduction: Bovine postpartum metritis causes great losses. Mast cell (MC)-released mediators participate in uterine inflammation and immune response, but their role in postpartum metritis in cows has not been reported. This study investigated the effect of endometrial MC on the disorder.

  6. A Role for Imagery in Mentoring.

    Science.gov (United States)

    Fletcher, Sarah

    2000-01-01

    Examples of imagery and visualization in medicine, sports, and preservice teaching explore the potential of these techniques in mentoring relationships. They help proteges develop a positive self-image in a new role, make mentors' experience more explicit, and depict possible selves toward which proteges can work. (SK)

  7. The Role of Anxiety in Career Indecisiveness.

    Science.gov (United States)

    Kaplan, David M.; Brown, Duane

    1987-01-01

    Administered Career Decision Scale and Self-Evaluation Questionnaire to college students to examine role of anxiety as antecedent or consequence in career indecisiveness. Investigated two theories of career indecisiveness and found both to have merit. Suggests there may be two types of career indecisive individuals. (NB)

  8. [The role of accommodation in functional strabismus].

    Science.gov (United States)

    Cernea, P; Ignat, F

    1992-01-01

    The accommodative reflex unleash is produced by many stimuli, of which the most important are the lack of clarity of the retinal image and the convergence. The ciliary muscles, although innervated by vegetative fibres, behave like striated fibres. It is also discussed the role of accommodation in the appearance of functional strabismus.

  9. Spatial roles and verbal directionality in Dinka

    DEFF Research Database (Denmark)

    Andersen, Torben

    2012-01-01

    This article deals with the interaction between two subsystems of the grammar of Dinka, a Western Nilotic language: (i) the semantic role of a place adverbial as location, source or goal, and (ii) deictic directionality expressed in the verb. Some place adverbials do not encode the distinction be...

  10. Role of Flexibility in Sustainable Port Development

    NARCIS (Netherlands)

    Taneja, P.; Vellinga, T.; Ros, R.

    2012-01-01

    Sustainability has become a high profile objective in all aspects of our lives, including the development of our infrastructures. Flexibility can enhance sustainability endeavors, yet its contribution is not clear to most. In this paper we investigate the role of flexibility in sustainable port

  11. Parent Perspectives on the Roles of Paraprofessionals.

    Science.gov (United States)

    French, Nancy K.; Chopra, Ritu V.

    1999-01-01

    Nineteen mothers of 23 children who received special education services in inclusive classrooms with support from paraprofessionals found that the mothers identified closely with paraprofessionals and believed that they were compassionate, dedicated people who functioned in four major roles: connector, team member, instructor, and physical…

  12. Sport and Sex-Role Orientation.

    Science.gov (United States)

    Fisher, A. Craig

    Psychosexual personality is not exclusively a postnatal and learned phenomenon. Three biologically-based sex differences can be cited as having promoted status differentiation between males and females. These are (a) greater physical strength of males, (b) greater aggressiveness of males, and (c) child-rearing and nursing roles of females. The…

  13. Homework Practices: Role Conflicts Concerning Parental Involvement

    Science.gov (United States)

    Bräu, Karin; Harring, Marius; Weyl, Christin

    2017-01-01

    This article on hand discusses results of an ethnographic study which aims to perform a detailed description of practices of doing homework in a domestic environment. Based on the international state of research, first the question and the methodical approach will be explained, subsequently the role conflicts and stress ratios developed while…

  14. The role of the laparoscopic nurse practitioner.

    Science.gov (United States)

    Caballero, C

    Since the appointment of the author as laparoscopic nurse practitioner at Milton Keynes Hospital Trust, there have been more cholecystectomy operations, but fewer patients have required open surgery or inpatient admission, with substantial cost savings. The author describes how the role developed and the opportunities it presents for nurses.

  15. Role enactment of facilitation in primary care

    DEFF Research Database (Denmark)

    Due, Tina Drud; Thorsen, Thorkil; Waldorff, Frans Boch

    2017-01-01

    organisations. The complexity of the facilitation field and diversity of potential facilitator roles fosters a need to investigate in detail how facilitation is enacted. Hence, the purpose of this study was to explore the enactment of external peer facilitation in general practice in order to create a stronger...

  16. Role Playing, Issue Importance, and Attitude Change.

    Science.gov (United States)

    Sarup, Gian

    1981-01-01

    Contrasted three major theories on attitude change: cognitive dissonance, incentive, and social judgment. Results from student questionnaires provided little support for cognitive dissonance. Also provided credible, though overlapping, evidence for incentive and social judgment theories. Improvised role playing produced more change than did…

  17. Errors in science: the role of reviewers

    NARCIS (Netherlands)

    Szekely, T.; Kruger, O.; Krause, E.T.

    2014-01-01

    Reviewers play a key role in science, although studies suggest the current peer-reviewing system has faults. We propose to introduce a quality control system to evaluate each journal’s review process, and produce a Review Quality Index. We propose four schemes that have the potential to reduce

  18. Choices: Learning about Changing Sex Roles.

    Science.gov (United States)

    Wangen, Nancy Register; Wagner, Sherri

    Maintaining that sexism wastes talents by limiting an individual's choices, the document presents activities for elementary school students to increase awareness of sex roles and a set of inservice materials for training school personnel to teach about sexism. Activities are presented on two levels. Activities for primary grades deal with…

  19. Insight: Exploring Hidden Roles in Collaborative Play

    Directory of Open Access Journals (Sweden)

    Tricia Shi

    2015-06-01

    Full Text Available This paper looks into interaction modes between players in co-located, collaborative games. In particular, hidden traitor games, in which one or more players is secretly working against the group mission, has the effect of increasing paranoia and distrust between players, so this paper looks into the opposite of a hidden traitor – a hidden benefactor. Rather than sabotaging the group mission, the hidden benefactor would help the group achieve the end goal while still having a reason to stay hidden. The paper explores what games with such a role can look like and how the role changes player interactions. Finally, the paper addresses the divide between video game and board game interaction modes; hidden roles are not common within video games, but they are of growing prevalence in board games. This fact, combined with the exploration of hidden benefactors, reveals that hidden roles is a mechanic that video games should develop into in order to match board games’ complexity of player interaction modes.

  20. Restructuring Superpowers: The Role of the Military

    Science.gov (United States)

    1991-05-24

    Security Classification) ’ estructuring Superpowers: The Role of the Military 2 PERSONAL AUTHOR(S) ,TC Hubert Bridges, Jr. 3a TYPE OF REPORT 113b. TIME...ground down both military and homefront morale: the cost c the arms race had nearly bankrupt the one-dimensional Soviet economy, the emergence of a global

  1. The role of beliefs in teacher agency

    DEFF Research Database (Denmark)

    Biesta, Gert; Priestley, Mark; Robinson, Sarah

    2015-01-01

    that beliefs play an important role in teachers’ work, an apparent mismatch between teachers’ individual beliefs and values and wider institutional discourses and cultures, and a relative lack of a clear and robust professional vision of the purposes of education indicate that the promotion of teacher agency...

  2. The Principal's Role in Reporting Child Abuse.

    Science.gov (United States)

    Payne, Beth

    1991-01-01

    The role of the principal in identifying and reporting child abuse and neglect is discussed in this bulletin. Although all 50 states and the District of Columbia have laws that require educators to report cases in which they have knowledge or reasonable cause to suspect child abuse, passage of legislation does not always lead to compliance.…

  3. Dynamic Roles and Locations of Manufacturing

    DEFF Research Database (Denmark)

    Slepniov, Dmitrij; Wæhrens, Brian Vejrum; Johansen, John

    2014-01-01

    Purpose – The principal objective of this paper is to relate functional nodes of production and innovation in global operations networks. The authors aim to capture the implications of changing strategic roles and locations of manufacturing for innovation capabilities. Design/methodology/approach......Purpose – The principal objective of this paper is to relate functional nodes of production and innovation in global operations networks. The authors aim to capture the implications of changing strategic roles and locations of manufacturing for innovation capabilities. Design...... companies presented in this paper, the authors find that although the potential benefits of global dispersion of manufacturing are vast, the realisation of these potentials depends on how successful companies are with linking the new strategic roles and locations of manufacturing with innovation...... at their home base. The paper identifies and discusses groups of capabilities important to this link. Practical implications – Three propositions are developed to advance the understanding of the role of cross-functional coordination and alignment, as well as their significance in the strategic initiatives...

  4. New roles for the trade unions

    DEFF Research Database (Denmark)

    Kristensen, Peer Hull; Rocha, Robson Silva Sø

    2012-01-01

    This article builds on lessons from Denmark and the Nordic area to offer a novel and comprehensive logic of action within the emerging political economy that may be used to assess the possible new roles that unions can take on. The authors argue that unions are capable of “civilizing” globalizati...

  5. A Neglected Role for Organizational Design

    DEFF Research Database (Denmark)

    Stea, Diego; Foss, Kirsten; Foss, Nicolai Juul

    2015-01-01

    that management may renege on delegated decision rights has negative motivational consequences that are costly in knowledge-intensive organizations. As a consequence, making delegation credible is essential for sustaining the advantages that flow from delegation. Organizational design can play a key role...

  6. SCFA – role in colonic disease

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. SCFA – role in colonic disease. Improve epithelial cell energy metabolism in colitis. Ahmed et al, Gut 2000. Increase sodium and water absorption in diarrhoea, and can be used in oral rehydration therapy. Ramakrishna et al, NEJM 2000. Hasten epithelial renewal ...

  7. The Role of Touch in Facilitated Communication.

    Science.gov (United States)

    Kezuka, Emiko

    1997-01-01

    A study investigated the role of touch in the use of facilitated communication with Japanese individuals with autism. Five experiments were conducted involving a "telepathy game" using a rod with an attached strain gauge. Results found the facilitator's contact controlled the motor responses of the subjects. (Author/CR)

  8. THE ROLE OF ADVERTISING, PUBLICITY AND PUBLIC ...

    African Journals Online (AJOL)

    Mitch

    This is not out of place because it has its role to play in marketing, but the fact is that its reach cannot be compared to advertising through the electronic media. On another plane, let us evaluate how Advertising, Publicity and Public Relations are applied in the managing of University of Benin educational theatre managed by ...

  9. The Role of Macronutrients in Exercise.

    Science.gov (United States)

    Arterberry, Christopher M.

    2002-01-01

    Explores the role of macronutrients in exercise, examining research pertaining to exercise intensity, exercise duration, macronutrient intake, and mode of exercise as they pertain to both athletes and recreational exercisers. The paper explains that coaches and trainers must interpret and apply research findings to individual exercisers,…

  10. Role of Outer Membrane Vesicles of Bacteria

    Indian Academy of Sciences (India)

    IAS Admin

    nificant role in cell-to-cell communication, virulence, nutri- tion and protection of the bacterial cells from ... communication with other microorganisms and also with the host cells. It is also essential for detoxification of ..... are known to evolve with different types of strategies that make them immune to the growth-inhibitory or.

  11. Training and the Change Agent Role Model

    Science.gov (United States)

    Leach, Wesley B.; Owens, Vyrle W.

    1973-01-01

    The authors discuss the qualities possessed by a model change agent and roles played by him as resident technical participant: analyst, advisor, advocate, systems linker, innovator, and trainer. Besides presenting the teaching plan for change agents, the authors call upon their Peace Corps experiences to provide specific examples of what is…

  12. Communication Theory's Role in the Reference Interview.

    Science.gov (United States)

    Glogoff, Stuart

    1983-01-01

    Notes the applicability of communication science theory to the reference process, particularly in areas involving human behavior, and discusses the roles of both verbal and nonverbal communication (body language, paralanguage, proxemics, and environmental factors) in the reference interview. Forty-one references are provided. (EJS)

  13. Role of antioxidant scavenging enzymes and extracellular ...

    African Journals Online (AJOL)

    In the present work, we studied the role of antioxidant scavenging enzymes of plant pathogenic bacteria: catalase, ascorbate peroxidase and a virulence factor; extracelluar polysaccharide production in determining the virulence of Xanthomonas oryzae pv. oryzae (Xoo) isolates and its differential reaction to rice cultivars.

  14. Evaluation: The New Philosophical Roles & Psychological Means

    OpenAIRE

    Prashant M. Dolia

    2013-01-01

    Evaluation Roles and Means are very broad. It concerns with n number of attributes. This paper discussed the relationship between evaluation & research, philosophy of evaluation, physiology of evaluation, Evaluation in applied psychology. In the above context, how the basic logic of evaluation is set with evaluation fields and the phases of evaluation process.

  15. Redesigning Our Role While Redesigning Our Libraries

    Science.gov (United States)

    Bradburn, Frances Bryant

    2013-01-01

    This article describes a process one librarian discovered and implemented as she observed the changing role of the librarian and the library. Frustration was growing due to the gradual erosion of school libraries as they struggled to remain, with electronic books, video streaming, and databases supplanting many of the physical resources in the…

  16. Role-Based Design: Design Experiences

    Science.gov (United States)

    Miller, Charles; Hokanson, Brad; Doering, Aaron; Brandt, Tom

    2010-01-01

    This is the fourth and final installment in a series of articles presenting a new outlook on the methods of instructional design. These articles examine the nature of the process of instructional design and are meant to stimulate discussion about the roles of designers in the fields of instructional design, the learning sciences, and interaction…

  17. Educational role-play: moving beyond entertainment

    DEFF Research Database (Denmark)

    Duus Henriksen, Thomas

    This paper presents a controversial approach to innovating educational role-play. It is argued that we should stop thinking games as an entertaining mean for facilitating participation, and instead try to see games as a content provider and feedback mechanism. A theoretical model is presented...

  18. The Role of Statistics in Kosovo Enterprises

    Science.gov (United States)

    Gjonbalaj, Muje; Dema, Marjan; Miftari, Iliriana

    2009-01-01

    Considering science as the main contributor to contemporary developments has encouraged us to raise a scientific discussion regarding the role of statistics in business decision-making and economic development. Statistics, as an applicative science, is growing and being widely applied in different fields and professions. Statistical thinking is…

  19. Role of Cardiolipin in Mitochondrial Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Jan Dudek

    2017-09-01

    Full Text Available The phospholipid cardiolipin (CL is an essential constituent of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy conversion. Pathological changes in CL amount or species composition can have deleterious consequences for mitochondrial function and trigger the production of reactive oxygen species. Signaling networks monitor mitochondrial function and trigger an adequate cellular response. Here, we summarize the role of CL in cellular signaling pathways and focus on tissues with high-energy demand, like the heart. CL itself was recently identified as a precursor for the formation of lipid mediators. We highlight the concept of CL as a signaling platform. CL is exposed to the outer mitochondrial membrane upon mitochondrial stress and CL domains serve as a binding site in many cellular signaling events. During mitophagy, CL interacts with essential players of mitophagy like Beclin 1 and recruits the autophagic machinery by its interaction with LC3. Apoptotic signaling pathways require CL as a binding platform to recruit apoptotic factors such as tBid, Bax, caspase-8. CL required for the activation of the inflammasome and plays a role in inflammatory signaling. As changes in CL species composition has been observed in many diseases, the signaling pathways described here may play a general role in pathology.

  20. The role of senescent cells in ageing

    NARCIS (Netherlands)

    Deursen, J.M.A. van

    2014-01-01

    Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights

  1. The Role of Emotion in Word Learning

    Science.gov (United States)

    Doan, S. N.

    2010-01-01

    The way in which emotion interacts with cognition has been of great interest to researchers for hundreds of years. Emotion has been shown to play an important role in attention, learning and memory. However, the way in which emotion influences the basic process of word learning in infancy has largely been ignored. In the current paper, the…

  2. Role of lactoferrin in the tear film.

    Science.gov (United States)

    Flanagan, J L; Willcox, M D P

    2009-01-01

    The surface of the eye provides an inert barrier against infection. Through its unique combination of antimicrobial action and anti-inflammatory activities lactoferrin (Lf) in the tear film plays an important role in the maintenance of ocular health. In order to maintain clarity the eye must provide immunological defense without immunopathology. Along with physical barriers, soluble plasma factors and other proteins such as lysozyme, Lf produced by the acinar cells of the lacrimal gland serves a number of roles in defense for this purpose. Lf in tears provides antimicrobial efficacy by binding free iron thus reducing the availability of iron necessary for microbial growth and survival as well as pathogenesis. Lf has been shown to inhibit biofilm formation and thus may play a role in protecting contact lens surfaces from colonization. Virus particles' entry into epithelial cells is inhibited by Lf while an excess of Lf in tear film is thought to limit the opportunistic Lf-mediated bridging of adenovirus and host cell that occurs in other tissues. Lf dampens the classical complement activation pathway by binding to markers of inflammation and immune activation while pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are targeted by Lf for removal through tears and hydrodynamic flushing. This review focuses on the role of Lf in human tear film and its contribution to ocular health during contact lens wear.

  3. Role of the Public Library Trustee.

    Science.gov (United States)

    Christenson, John

    1995-01-01

    Examines the functions, roles, and responsibilities of the public library trustee in a rural setting. Topics include serving the information needs of the community, determining policy, encouraging partnerships with other libraries and community organizations, ensuring sufficient funding, public and community relations, and evaluation of the board…

  4. ROLE OF INTERNET IN INSURANCE SERVICES REALIZATION

    Directory of Open Access Journals (Sweden)

    N. Prikazyuk

    2014-03-01

    Full Text Available The role of the Internet in the implementation of insurance products is investigated. It is founded the Internet in insurance performs presentable and realizable function. The benefits of using Internet technologies for business of insurance market are determined.

  5. Reintegration: The Role of Spouse Telephone Battlemind

    Science.gov (United States)

    2011-10-01

    treating a service member or veteran . Spouses can have a dramatic effect on the reintegration of the family after deployment and can be a major support...Physical Health in a Sample of Spouses of OEF/OIF Service Members .......... 37 Easing Reintegration : Telephone Support Groups for Spouses of...68 Reintegration : The Role of Spouse Telephone BATTLEMIND Pilot Project

  6. Stress from Role Conflict: Consequences for Professional ...

    African Journals Online (AJOL)

    An ex-post facto data collected from 600 teachers and 2400 senior secondary two students from Cross River State were analyzed to determine the influence of stress arising from role conflict on professional effectiveness. One hypothesis was tested using One-Way Analysis of Variance. The result of the data analyses ...

  7. The Role of Innate Immunity in Autoimmunity

    Science.gov (United States)

    Bach, Jean-François; Bendelac, Albert; Brenner, Michael B.; Cantor, Harvey; De Libero, Gennaro; Kronenberg, Mitchell; Lanier, Lewis L.; Raulet, David H.; Shlomchik, Mark J.; von Herrath, Matthias G.

    2004-01-01

    During the 2004 International Congress of Immunology in Montreal, a panel of experts gathered for an “Ideashop” discussion on the potential role of innate immunity in autoimmunity and the ways in which this might be targeted in future therapies. PMID:15611284

  8. Macrophages: Their Emerging Roles in Bone

    Science.gov (United States)

    Sinder, Benjamin P; Pettit, Allison R; McCauley, Laurie K

    2016-01-01

    Macrophages are present in nearly all tissues and are critical for development, homeostasis, and regeneration. Resident tissue macrophages of bone, termed osteal macrophages, are recently classified myeloid cells that are distinct from osteoclasts. Osteal macrophages are located immediately adjacent to osteoblasts, regulate bone formation, and play diverse roles in skeletal homeostasis. Genetic or pharmacological modulation of macrophages in vivo results in significant bone phenotypes, and these phenotypes depend on which macrophage subsets are altered. Macrophages are also key mediators of osseous wound healing and fracture repair, with distinct roles at various stages of the repair process. A central function of macrophages is their phagocytic ability. Each day, billions of cells die in the body and efferocytosis (phagocytosis of apoptotic cells) is a critical process in both clearing dead cells and recruitment of replacement progenitor cells to maintain homeostasis. Recent data suggest a role for efferocytosis in bone biology and these new mechanisms are outlined. Finally, although macrophages have an established role in primary tumors, emerging evidence suggests that macrophages in bone support cancers which preferentially metastasize to the skeleton. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as therapeutic and regenerative approaches vital for skeletal health. PMID:26531055

  9. Accelerated Learning: Future Roles and Influences.

    Science.gov (United States)

    Wlodkowski, Raymond J.; Kasworm, Carol E.

    2003-01-01

    Accelerated learning fills a much-needed role for nontraditional learners. Its popularity and success suggest models for more effective and less costly reforms in higher education. It also requires close monitoring of quality, student outcomes, and the potential for commercialization. (SK)

  10. Communicating the role of genetics in management

    Science.gov (United States)

    Mary F. Mahalovich

    1997-01-01

    Three current issues serve as examples to convey the role of genetics in management. (1) Consequences of silvicultural systems on the genetic resource of tree species are limited to one generation of study and isozyme (qualitative) data. Results of simulated data for diameter (quantitative data) over several generations, illustrate the pitfalls of working towards...

  11. Probabilistic Role Models and the Guarded Fragment

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2004-01-01

    We propose a uniform semantic framework for interpreting probabilistic concept subsumption and probabilistic role quantification through statistical sampling distributions. This general semantic principle serves as the foundation for the development of a probabilistic version of the guarded fragm...... fragment of first-order logic. A characterization of equivalence in that logic in terms of bisimulations is given....

  12. Probabilistic role models and the guarded fragment

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2006-01-01

    We propose a uniform semantic framework for interpreting probabilistic concept subsumption and probabilistic role quantification through statistical sampling distributions. This general semantic principle serves as the foundation for the development of a probabilistic version of the guarded fragm...... fragment of first-order logic. A characterization of equivalence in that logic in terms of bisimulations is given....

  13. On the Role of Nuclear Energy

    Science.gov (United States)

    Parsegian, V. Lawrence

    1974-01-01

    The author elaborates on the thesis that much of the confusion and argument about the role of nuclear energy in meeting the energy needs of the nation and the world is caused by failure to place the known facts in perspective with respect to time, to hazards that accompany the use of energy in any form, to economics, and to ultimate limitations in…

  14. Phenotypic variation in plants : Roles for epigenetics

    NARCIS (Netherlands)

    Lauss, K.

    2017-01-01

    Besides genetics, also epigenetics can play a role in shaping the characteristics of a plant (phenotype). Epigenetics refers to chemical modifications of DNA and proteins associated with the DNA that can influence gene activity (the ‘epigenome’) and can be passed on through cell divisions and

  15. Integrating Technology: The Principals' Role and Effect

    Science.gov (United States)

    Machado, Lucas J.; Chung, Chia-Jung

    2015-01-01

    There are many factors that influence technology integration in the classroom such as teacher willingness, availability of hardware, and professional development of staff. Taking into account these elements, this paper describes research on technology integration with a focus on principals' attitudes. The role of the principal in classroom…

  16. Adropin – physiological and pathophysiological role

    Directory of Open Access Journals (Sweden)

    Natalia Marczuk

    2016-09-01

    Full Text Available Adropin is a peptide hormone that was discovered in 2008 by Kumar et al. This protein consists of 76 amino acids, and it was originally described as a secreted peptide, with residues 1-33 encoding a secretory signal peptide sequence. The amino acid sequence of this protein in humans, mice and rats is identical. While our knowledge of the exact physiological roles of this poorly understood peptide continues to evolve, recent data suggest a role in energy homeostasis and the control of glucose and fatty acid metabolism. This protein is encoded by the Enho gene, which is expressed primarily in the liver and the central nervous system. The regulation of adropin secretion is controversial. Adropin immunoreactivity has been reported by several laboratories in the circulation of humans, non-human primates and rodents. However, more recently it has been suggested that adropin is a membrane-bound protein that modulates cell-cell communication. Moreover, adropin has been detected in various tissues and body fluids, such as brain, cerebellum, liver, kidney, heart, pancreas, small intestine, endothelial cells, colostrum, cheese whey and milk. The protein level, as shown by previous research, changes in various physiological and pathophysiological conditions. Adropin is involved in carbohydrate-lipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. The knowledge of this interesting protein, its exact role and mechanism of action is insufficient. This article provides an overview of the existing literature about the role of adropin, both in physiological and pathophysiological conditions.

  17. The Occupations of Literacy: Occupational Therapy's Role

    Science.gov (United States)

    Frolek Clark, Gloria

    2016-01-01

    Nationally, student proficiency in reading and writing is very low and requires ongoing focus from state and local agencies. With almost 25% of occupational therapists working in early intervention and school settings (AOTA, 2015), their role of facilitating literacy (e.g., reading, writing, speaking and listening) is critical. Occupational…

  18. The Role of Adipocytokines in Coronary Atherosclerosis.

    Science.gov (United States)

    Liberale, Luca; Bonaventura, Aldo; Vecchiè, Alessandra; Matteo, Casula; Dallegri, Franco; Montecucco, Fabrizio; Carbone, Federico

    2017-02-01

    The aim of this review is to overview the pathophysiological role of adipocytokines in atherogenesis, focusing on their potential role as biomarkers of coronary disease. Several lines of evidence indicated adipose tissue not only as depot but rather as an endocrine organ. In this context, the balance between pro- and anti-inflammatory adipocytokines has been shown to critically regulate vascular homeostasis in both physiological and pathophysiological conditions. Overweight and obesity are characterized by dysfunctional adipose tissue and then the prevalence of pro-inflammatory mediators, with a detrimental effect on vascular health. As opposite to adiponectin, pro-inflammatory adipocytokines, such as leptin and resistin, promote endothelial dysfunction and inflammatory processes involved in atherosclerotic plaque progression and vulnerability. Therefore, many adipocytokines have been investigated as potential biomarkers of cardiovascular (CV) risk, but their role has not yet been clearly established. Furthermore, the perivascular adipose tissue recently emerged as a critical modulator of atherosclerotic processes, due to the close interaction with the underlying vascular tissue. The ongoing discovery of new adipocytokines and the complex pathophysiological role of the different adipose tissue depots strongly contribute to define the complexity of adipocytokines network. Understanding those complex interactions may allow determining new potential biomarkers of CV risk and potential therapeutic targets.

  19. Rethinking Education--Emerging Roles for Teachers

    Science.gov (United States)

    Dar, Fatima Rehan

    2015-01-01

    The purpose of the study was to find out how teachers role modeled and taught empathetic and pro-social skills at the primary level. The study was qualitative in nature and followed a case study approach. Observations of regular English language classes were done from Grades 1-5 to see if class lessons incorporated the said themes and whether…

  20. The role of dendritic cells in cancer

    DEFF Research Database (Denmark)

    Hansen, Morten; Andersen, Mads Hald

    2017-01-01

    infiltrating human tumors, but less information is known about how these T-cells gain access to the tumor or how they are primed to become tumor-specific. Here, we highlight recent findings that demonstrate a vital role of CD103+ DCs, which have been shown to be experts in cross-priming and the induction...

  1. Signalling role of skeletal muscle during exercise

    NARCIS (Netherlands)

    Catoire, M.

    2014-01-01

    Abstract Upon  acute exercise skeletal muscle is immediately and heavily recruited, while other organs appear to play only a minor role during exercise. These other organs show significant changes and improvements in function, although they are not directly targeted by

  2. My Role as an EPA Scientist

    Science.gov (United States)

    I will first describe my role as a Research Ecologist with the EPA’s Office of Research and Development, National Health and Environmental Effects Research Laboratory, Western Ecology Division, in Corvallis, Oregon, an example of a government agency conducting research in E...

  3. The Changing Role Of The Innovative Teacher

    NARCIS (Netherlands)

    Dr.Ir. Hay Geraedts; Drs. Ing. Ricardo Abdoel

    2011-01-01

    This paper describes a research about the changing role and competences of teachers and the willingness of the teachers to change. The researchers developed and conducted a survey at Fontys University of Applied Sciences department engineering to find out how teachers teach and how they would want

  4. Transendothelial Transport and Its Role in Therapeutics.

    Science.gov (United States)

    Upadhyay, Ravi Kant

    2014-01-01

    Present review paper highlights role of BBB in endothelial transport of various substances into the brain. More specifically, permeability functions of BBB in transendothelial transport of various substances such as metabolic fuels, ethanol, amino acids, proteins, peptides, lipids, vitamins, neurotransmitters, monocarbxylic acids, gases, water, and minerals in the peripheral circulation and into the brain have been widely explained. In addition, roles of various receptors, ATP powered pumps, channels, and transporters in transport of vital molecules in maintenance of homeostasis and normal body functions have been described in detail. Major role of integral membrane proteins, carriers, or transporters in drug transport is highlighted. Both diffusion and carrier mediated transport mechanisms which facilitate molecular trafficking through transcellular route to maintain influx and outflux of important nutrients and metabolic substances are elucidated. Present review paper aims to emphasize role of important transport systems with their recent advancements in CNS protection mainly for providing a rapid clinical aid to patients. This review also suggests requirement of new well-designed therapeutic strategies mainly potential techniques, appropriate drug formulations, and new transport systems for quick, easy, and safe delivery of drugs across blood brain barrier to save the life of tumor and virus infected patients.

  5. THE ROLE OF PROSTAGLANDINS IN LIVESTOCK PRODUCTION

    African Journals Online (AJOL)

    2015-05-05

    May 5, 2015 ... important regulators of female productive functions (ovulation, uterine receptivity, Implantation and parturition) and associated with ... reproductive processes, hence, this paper seeks to review the role of Prostaglandins which is exploited in livestock .... ovarian oxytocin form part of the physiological stimulus.

  6. Dual Role of the Urban Reading Specialist

    Science.gov (United States)

    Lapp, Diane; Fisher, Douglas; Flood, James; Frey, Nancy

    2003-01-01

    Reading specialists in several San Diego schools assist both in providing tutoring to students and coach peers, a dual role that has helped to create and sustain schoolwide improvements in literacy. In just a few years, these high-poverty schools have doubled the number of 2nd graders reading at grade level.

  7. Filial Role Enactment by Adult Children.

    Science.gov (United States)

    Hamon, Raeann R.

    1992-01-01

    Used data from 144 elderly parent-adult child pairs to examine family caregiving. Final multiple regression model accounted for 63.2 percent of variability in filial role enactment. One main effect, parental marital status, and two interaction effects, child's gender with parental health and adult child's affection toward parent with geographical…

  8. Siderophores in environmental research: roles and applications.

    Science.gov (United States)

    Ahmed, E; Holmström, S J M

    2014-05-01

    Siderophores are organic compounds with low molecular masses that are produced by microorganisms and plants growing under low iron conditions. The primary function of these compounds is to chelate the ferric iron [Fe(III)] from different terrestrial and aquatic habitats and thereby make it available for microbial and plant cells. Siderophores have received much attention in recent years because of their potential roles and applications in various areas of environmental research. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. The aim of this literature review is to outline and discuss the important roles and functions of siderophores in different environmental habitats and emphasize the significant roles that these small organic molecules could play in applied environmental processes. © 2014 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

  9. Gender differences in depression across parental roles.

    Science.gov (United States)

    Shafer, Kevin; Pace, Garrett T

    2015-04-01

    Prior research has focused on the relationship between parenthood and psychological well-being, with mixed results. Some studies have also addressed potential gender differences in this relationship, again yielding varied findings. One reason may be methodological choices pursued in these studies, including the lack of focus on combined parental roles (for example, biological parent and stepparent). The authors used data from the National Longitudinal Survey of Youth, 1979 (N = 6,276) and multinomial treatment models to address how combined roles influence depressive symptoms in mothers and fathers. Further, they explored potential gender differences. Their results indicated that having multiple parental roles is negatively associated with psychological well-being for both men and women, whereas childlessness is more negative for women, and specific parental role combinations affect mothers and fathers differently. Within the context of changing family structure in the United States, these results have important implications for social workers and other mental health professionals-particularly with regard to screening for depression among parents, who are less likely to seek mental health counseling than childless adults.

  10. The Role of Pathogenic Autoantibodies in Autoimmunity

    Directory of Open Access Journals (Sweden)

    Merrill J. Rowley

    2015-11-01

    Full Text Available The serological presence of autoantibodies is diagnostic of autoimmunity, and these autoantibodies may be present for many years before the presentation of autoimmune disease (AID. Although a pathogenic role has been demonstrated for various autoantibodies reactive with cell surface and extracellular autoantigens, studies using monoclonal antibodies (mAb show not all antibodies in the polyclonal response are pathogenic. Differences depend on Fab-mediated diversity in epitope specificity, Fc-mediated effects based on immunoglobulin (Ig class and subclass, activation of complement, and the milieu in which the reaction occurs. These autoantibodies often occur in organ-specific AID and this review illustrates their pathogenic and highly specific effects. The role of autoantibodies associated with intracellular antigens is less clear. In vitro they may inhibit or adversely affect well-defined intracellular biochemical pathways, yet, in vivo they are separated from their autoantigens by multiple cellular barriers. Recent evidence that Ig can traverse cell membranes, interact with intracellular proteins, and induce apoptosis has provided new evidence for a pathogenic role for such autoantibodies. An understanding of how autoantibodies behave in the polyclonal response and their role in pathogenesis of AID may help identify populations of culprit B-cells and selection of treatments that suppress or eliminate them.

  11. The Wider Pedagogical Role of Teaching Assistants

    Science.gov (United States)

    Webster, Rob; Blatchford, Peter; Bassett, Paul; Brown, Penelope; Martin, Clare; Russell, Anthony

    2011-01-01

    Teaching assistants (TAs) comprise a quarter of the school workforce in England and Wales. There has been controversy over TAs' deployment and appropriate role regarding supporting learning and these debates have been transformed by findings from the largest study of school support staff (the DISS project), which show that TA support has a…

  12. Reinvigorating the role of science in democracy.

    Science.gov (United States)

    Rosenberg, Andrew A; Halpern, Michael; Shulman, Seth; Wexler, Celia; Phartiyal, Pallavi

    2013-01-01

    Private and political interests routinely conspire to sideline and misrepresent science and evidence in the public policy process. The Center for Science and Democracy, a new initiative at the Union of Concerned Scientists, endeavors to change this dynamic to strengthen the role of science in decision making.

  13. The Role of New Hire Orientation Programs

    Science.gov (United States)

    Dunn, Steven; Jasinski, Dale

    2009-01-01

    A vital component of a firm's human resource management is its new hire orientation (NHO) program. The authors' review of extant literature suggests that NHO programs can be organized based on a reconceptualization of human capital. Using their typology, a firm can organize the role and scope of its NHO program, assign responsibility for the…

  14. English Language Teaching: Role of a Teacher

    OpenAIRE

    Anamika Shukla

    2012-01-01

    Teacher can change subject matter from prose to poetry, from essay writing to letter writing to prevent the class from monotonous routine. Audio-Visual aids can add to the presentation of the topic. Students can be encouraged to listen to English news and Key words: English teaching, language teaching, role of teacher

  15. Role of Wind Tunnels in Aircraft Design

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 1. Role of Wind Tunnels in Aircraft Design. S P Govinda Raju. General Article Volume 8 Issue 1 January 2003 pp 72-76. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/008/01/0072-0076. Keywords.

  16. Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

    National Research Council Canada - National Science Library

    Zhao, Xiurong; Song, Shen; Sun, Guanghua; Strong, Roger; Zhang, Jie; Grotta, James C; Aronowski, Jaroslaw

    2009-01-01

    .... Our study indicates that haptoglobin (Hp), an acute-phase response protein primarily synthesized in the liver and known to bind and neutralize Hb in the bloodstream, is also expressed in brain in which it plays an important role in defending...

  17. Thyroid Cancer: Role of RET and Beyond.

    Science.gov (United States)

    Carlomagno, Francesca

    2012-04-01

    Specific thyroid cancer histotypes, such as papillary and medullary thyroid carcinoma, display genetic rearrangements or point mutations of the RET gene, resulting in its oncogenic conversion. The molecular mechanisms mediating RET rearrangement with other genes and the role of partner genes in tumorigenesis have been described. In addition, the RET protein has become a molecular target for medullary thyroid carcinoma treatment.

  18. THE ROLE OF NUTRITIONAL INFORMATION IN ADDRESSING ...

    African Journals Online (AJOL)

    The paper discusses the role of nutritional information for addressing under-five child malnutrition in Tanzania. The paper is based on a master's dissertation whose objective was to determine the sources of nutritional information used to provide nutritional information to mothers in Maternal and Child Health (MCH) clinics, ...

  19. Roles of DNA methyltransferases in Arabidopsis development ...

    African Journals Online (AJOL)

    Mutations that cause severe loss of DNA methylation often leads to abnormal development. In the present review, we summarized recent findings of the three major DNA methyltransferases mutants playing vital role in development of Arabidopsis thaliana. Keywords: DNA methylation, epigenetics, methyltransferase, mutant ...

  20. Forensic Learning Disability Nursing Role Analysis

    Science.gov (United States)

    Mason, Tom; Phipps, Dianne; Melling, Kat

    2011-01-01

    This article reports on a study carried out on the role constructs of forensic and nonforensic Learning Disability Nursing in relation to six binary themes. The aims were to identify if there were differences in perceptions of forensic learning disability nurses and nonforensic learning disability nurses in relation to the six binary themes of the…

  1. Internet Sirens & the Role of Today's Librarians.

    Science.gov (United States)

    Herlihy, Catherine S.

    2000-01-01

    Discusses both the opportunities and challenges to academic librarians of information resources available on the Internet. Notes that, beyond mechanical expertise, there are intellectual problems regarding research skills and critical assessment that have increased with the sheer amount of information available. The academic librarian's role is to…

  2. Role of metastructural matrixes in optimization ecotourism

    Directory of Open Access Journals (Sweden)

    A. N. Leuchin

    2010-01-01

    Full Text Available In the article possibilities anthropocentric and ecocentric developing paradigms ecotourism are shown. The updating role institutional functions ecotourism an expert by metastructural matrixes of optimization tourist-institutional space (TIS is specified. Long-range directions of socially-ecological interaction in system of ecotourism are designated, measures on optimisation of this interaction are considered.

  3. Epoxy adhesive plays crucial role at CERN

    CERN Multimedia

    2007-01-01

    "Epoxy adhesives are set to play a vital role in Europe's biggest-ever scientific experiment at the European Centrefor Nuclear Research (CERN) in Geneva, Switzerland, thereby helping scientists gain a better understanding of the origins of the universe." (1/2 page)

  4. Epoxy adhesive plays crucial role at CERN

    CERN Multimedia

    2006-01-01

    "Epoxy adhesives are set to play a vital role in Europe's biggest-ever scientific experiment at the European Centre for Nuclear Research (CERN) in Geneva, Switzerland, thereby helping scientists gain a better understanding of the origins of the universe." (1 page)

  5. Nurturing charge nurses for future leadership roles.

    Science.gov (United States)

    Patrician, Patricia A; Oliver, Douglas; Miltner, Rebecca S; Dawson, Martha; Ladner, Kathleen A

    2012-10-01

    Charge nurses are untapped leadership resources that can be groomed for future advanced leadership positions in healthcare organizations. The purpose of this study was to understand the development needs for the charge nurse role. This study demonstrates they receive little or no training for assuming positions of leadership and offers suggestions for enhancement of preparation.

  6. Understanding the roles of management accountants

    NARCIS (Netherlands)

    De Loo, I.G.M.; Verstegen, B.; Swagerman, D.M.

    2011-01-01

    The goal of this paper is to use a coherent conceptual framework to discern variables (triggers) that affect a management accountant’s role in an organization, thereby generating a comprehensive empirical picture of the management accountant profession in The Netherlands. Similar research was

  7. Role of vanadium in Bi-2223 ceramics

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 54; Issue 2. Role of vanadium in Bi-2223 ceramics. D R Mishra ... higher magnetization scattering at the Cu site. The results were explained keeping in mind the liquid phase mechanism behind the formation of the 2223 phase and the possibility of magnetic scattering.

  8. College Presidents' Role Performance and Faculty Satisfaction

    Science.gov (United States)

    Paxton, Dan R.; Thomas, Darwin L.

    1977-01-01

    Data gathered from 896 faculty members from two technical colleges, three community colleges, two private universities, and three public universities revealed three dimensions of the presidential role: personal-public image, faculty and student interaction with presidents, and absence of autocratic leadership style. (Author/LBH)

  9. The role of policy for documentary systems

    Directory of Open Access Journals (Sweden)

    Maria Mata Caravaca

    2015-05-01

    Full Text Available The article analyzes the role that policies have in guaranteeing the quality of creation, management and maintenance of digital resources, and offers an overview of national and international policies and standards that refer to records management and digital preservation. Finally, the article illustrates ICCROM’s records management manual and its digital preservation policy and strategy.

  10. Effective strategic leadership: Balancing roles during church ...

    African Journals Online (AJOL)

    2011-08-15

    Aug 15, 2011 ... and effectively react to change', as organisational inertia and argue that this term incorporates all related concepts ... a theory that explained the manifestation and management of resistance to change, or ... perspective of social capital theory, thereby contributing to understanding the role of strategic.

  11. The Role of Nuclear Power in Eurpoe

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-01-15

    The World Energy Council has published the results of an in-depth review of the current state of nuclear power in Europe, and the possible role of this energy source in Europe's energy future. This regional study combines policy insights, technical details and an analysis of the potential for nuclear as a part of the energy-mix.

  12. The Normal Distribution Some Roles of Normality

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 7. The Normal Distribution Some Roles of Normality. S Ramasubramanian. Series Article Volume 2 Issue 7 July 1997 pp 27-37. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/002/07/0027-0037 ...

  13. The role of education in mobile livelihoods

    DEFF Research Database (Denmark)

    Valentin, Karen

    2012-01-01

    Shedding light on the relationship between processes of migration and educational practices as aspects of wider livelihood strategies among young Nepalese migrants in India, this article focuses on the role of education in different phases of a migrant career. It explores firstly how education...

  14. Advancing lean manufacturing, the role of IT

    NARCIS (Netherlands)

    Riezebos, J.; Klingenberg, W.

    This introduction to the special issue discusses the changing role of information technology (IT) in advancing lean production. Lean principles and techniques have been applied in a wide variety of organisations, from make-to-stock to engineer-to-order industries, and even in typical service

  15. the surgical role of the clinical officer

    African Journals Online (AJOL)

    Practice Points: Bridging the health gap in Uganda: the surgical role of the clinical officer. ... determine their local investigative resources, the cases encountered by them in the two-week period preceding the course and the surgical and obstetric procedures that they ... African Journal of Health Sciences Vol.5(1) 2005: 86-89 ...

  16. Tensions within management roles in healthcare organisations.

    Science.gov (United States)

    Scott, Anne; Timmons, Stephen

    2017-03-30

    Aim This article reports the results of a study that gives an insight into ward leaders' perspectives of their leadership role and explores how they deliver leadership at ward level within organisational constraints and processes. Previous studies have been evaluations of clinical leadership in general, or literature reviews of the ward leader role. The aim of this study was to examine the leadership role of ward sisters and to understand how they lead improvements in quality of care on their wards. Methods A qualitative methodology was used, incorporating 19 in-depth interviews with ward leaders and modern matrons. Results Three main themes were identified: empty conformity, authority and autonomy, and visibility and leading by example. Participants aimed to be role models in leading and maintaining standards of care for patients, but this was sometimes constrained by organisational processes, lack of authority and autonomy, and lack of support and preparation. Conclusion Perceived differences between nursing and health service management mean that ward leaders' efforts to lead improvements in quality care are often undermined. Ward leaders must strike a balance between leading high-quality nursing care, in the context of organisational and political performance requirements, and the demands of administrative work, while often lacking autonomy and authority.

  17. The Role of Narrative in Multimedia Learning

    Science.gov (United States)

    Diamond, Myrna Elyse

    2011-01-01

    This descriptive case study investigated the role of narrative in multimedia learning and teaching and observed how teachers applied their understanding of narrative, and new constructivist technologies, to design multimedia presentations for instruction. The study looked specifically at the cognitive strategies, visual narrative concepts, and…

  18. Essential Role of Culture in Developmental Psychology

    Science.gov (United States)

    Miller, Joan G.

    2005-01-01

    This chapter argues for the essential role of culture in forming the basic constructs and theories of developmental psychology. The case is made for the need to overcome the cultural insularity of core developmental concepts and methods in order to create a psychology that is more truly universal.

  19. Role of intestinal microflora ( Lactobacillus Acidophilus ) in ...

    African Journals Online (AJOL)

    The prevalence of obesity, insulin resistance and type 2 diabetes has steadily increased in the last decades. In addition to the genetic and environmental factors, gut microbiota may play an important role in the modulation of intermediary phenotypes leading to metabolic disease. Infection is an important cause of morbidity ...

  20. Role of Behavior Theory in Behavioral Medicine.

    Science.gov (United States)

    Epstein, Leonard H.

    1992-01-01

    Defines behavioral medicine as multidisciplinary field that combines research methods from behavioral and biomedical sciences. Examines the role of behavior theory in behavioral medicine. Uses new advances in basic research on learning to illustrate that findings from behavioral science have implications for the field of contemporary behavioral…

  1. Media Roles and Legislators' New Media Use.

    Science.gov (United States)

    Riffe, Daniel

    1990-01-01

    Surveys 82 Alabama legislators and finds officials' views of the press as adversary or agent of consensus relates to perceived value of media for job-relevant information. Suggests a dysfunction of the "watch-dog" role because those believing the consensus model found the press more useful than those seeing the press as an adversary. (MG)

  2. The Role of Meditation in Addiction Recovery

    Science.gov (United States)

    Pruett, James M.; Nishimura, Nancy J.; Priest, Ronnie

    2007-01-01

    The authors examined the role of meditation as an important component in addiction recovery. Successful addiction recovery is often related to an individual's ability to develop and use a repertoire of coping behaviors, including the ability to maintain an ongoing awareness of one's vulnerability. These learned behaviors serve as reliable…

  3. Nurse Policy Analyst. Advanced Practice Role.

    Science.gov (United States)

    Stimpson, Marie; Hanley, Barbara

    1991-01-01

    The delivery of nursing care is enmeshed in the health care policy decisions made at state and national levels. The authors recommend an advanced practice role for nurse policy analysts, examine political decision-making processes that would be included in the curriculum, and give illustrative positions that graduate nurse policy analysts might…

  4. A study on impact of Job role stressors on Frontline employee role performance towards the customers

    Directory of Open Access Journals (Sweden)

    Kasturi Naik

    2016-03-01

    Full Text Available Rapid developments in the Indian Economy post-liberalization in 1991 have prompted institutions like the World Bank to forecast that India would be the fourth largest economy in the world by 2020 (Budhwar and Bhatnagar, 2009. Following globalization this has attracted a large numbers of foreign investors and companies to India. HRM in India has evolved as a specialised function (Budhwar and Bhatnagar, 2009. According to Budhwar and Bhatnagar, 2009 India had a long history of labour legislation and industrial relations and there are many challenges to the HRM systems in India, due to the diverse nature of India’s society which is marked by regional, sectoral, socio-cultural and political variation. In such a climate it is extremely difficult to have a uniform HR system. According to Wheatherly and Tansik (1993 employees have to deal with the demands from superiors as well as the needs and wishes of customers. Because of such a boundary spanning role, the retail frontline employees are in dilemma whether to customize the retail services as per customers needs or to obey the organizational guidelines and procedures (Bitner, 1990. This dilemma often leads to job role stress. There are different types of job role stress (Pareek, 1993 of these the research under study deals with the two job role stressors prominent in retail industry job role conflict and job role ambiguity ( Kahn et.al, 1964. According to Heskett et al. (2003 front line employee’s behavior and perception affects the customer satisfaction and intent of buying behavior which in turn have impact on service productivity. There have been many studies conducted on job role stress and its impact on employee job performance but hardly any with respect to organized Indian retail sector.In the prior research studies it can be noted that employee point of view is hardly taken into consideration. Hence as an attempt to fill in this gap the research focuses on understanding how job role

  5. Gender role biases on Indian television.

    Science.gov (United States)

    Behera, S K

    1989-01-01

    Gender role biases in Indian television have served to reinforce and even enhance the degradation of women in the broader society. A content analysis of 20 news programs, 20 fictionalized serials, and 100 commercials conducted over a 3-week period in 1988 indicated that women are portrayed as victims, caretakers, and sex objects while men are presented as masters, doers, and intellectuals. Of the 400 hours of news programs studied, men newsmakers accounted for 71% of the content while women were featured in only 10% of the segments. Even then, women's portrayal in the news tended to center on their roles as beneficiaries of welfare schemes, victims of accidents, or as the wives of male dignitaries. Fictionalized dramas reinforced the sex role stereotypes of men as decisive, assertive, dominant, and career- oriented, and of women as emotionally dependent, eager to please, sentimental, and primarily concerned with family relationships. Female characters in these series were most often housewives, secretaries, teachers, or nurses. Women were featured more often (56% of content) than men in Indian commercials, yet were shown performing stereotyped female activities such as shopping, preparing meals, and dressing to obtain the sexual approval of men. This sex role stereotyping in the media is seriously impeding the struggles of women in India to achieve economic and political autonomy. To promote more positive role modeling and change women's self-image, Indian television must move immediately to portray women achieving self-realization through their careers and social participation and to depict cooperation between men and women in performing household chores.

  6. Nurse consultants: organizational influences on role achievement.

    Science.gov (United States)

    Woodward, Valerie A; Webb, Christine; Prowse, Morag

    2006-03-01

    This paper reports on organizational influences on nurse consultant post holders. The influence of individual characteristics has been the subject of another paper. Nurse consultant posts were set up in the United Kingdom from the late 1990s onwards and, therefore, there has been little opportunity to report on evaluations of these innovative initiatives. A cross-sectional design, using a convenience sample, was adopted. Ten nurse consultants working in a variety of settings and specialties participated in in-depth, tape-recorded interviews. The data were analysed using the Framework approach. Support systems were important influences on nurse consultants' role achievement levels. These took the form of internal trust networks, nurse consultant forums and links with higher education institutions. Post holders both gave and received support and acted to empower other nurses. Thus, relationships were vital to successful role integration. The culture and structures of the National Health System were also a powerful influence in terms of local and national modernization policies, and participants had to be careful in their choice of strategies to deal with the traditional medically dominated culture. The new nurse consultant role is challenging and innovative, but a major area of contention is how much post holders are expected to take on work previously done by doctors rather than developing their nursing role. Organizational support and commitment are needed if nurse consultants are to maximize the benefits of this innovation. The findings show that new nursing roles are not always easily accepted in multidisciplinary settings and that holders of such post need to have the appropriate previous knowledge, skills and personal characteristics, as well as the ability to negotiate their way through organizational influences.

  7. Role of Vitamin D in Insulin Resistance

    Directory of Open Access Journals (Sweden)

    Chih-Chien Sung

    2012-01-01

    Full Text Available Vitamin D is characterized as a regulator of homeostasis of bone and mineral metabolism, but it can also provide nonskeletal actions because vitamin D receptors have been found in various tissues including the brain, prostate, breast, colon, pancreas, and immune cells. Bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation are all biological functions of vitamin D. Vitamin D may play an important role in modifying the risk of cardiometabolic outcomes, including diabetes mellitus (DM, hypertension, and cardiovascular disease. The incidence of type 2 DM is increasing worldwide and results from a lack of insulin or inadequate insulin secretion following increases in insulin resistance. Therefore, it has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes. The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1alpha-hydroxylase gene. Other roles have been proposed to involve immunoregulatory function by activating innate and adaptive immunity and cytokine release, activating inflammation by upregulation of nuclear factor κB and inducing tumor necrosis factor α, and other molecular actions to maintain glucose homeostasis and mediate insulin sensitivity by a low calcium status, obesity, or by elevating serum levels of parathyroid hormone. These effects of vitamin D deficiency, either acting in concert or alone, all serve to increase insulin resistance. Although there is evidence to support a relationship between vitamin D status and insulin resistance, the underlying mechanism requires further exploration. The purpose of this paper was to review the current information available concerning the role of vitamin D in insulin resistance.

  8. Provider role attitudes, marital satisfaction, role overload, and housework: a dyadic approach.

    Science.gov (United States)

    Helms, Heather M; Walls, Jill K; Crouter, Ann C; McHale, Susan M

    2010-10-01

    Treating the marital dyad as the unit of analysis, this study examined the within-couple patterning of 272 dual-earner spouses' provider role attitudes and their longitudinal associations with marital satisfaction, role overload, and the division of housework. Based on the congruence of husbands' and wives' provider role attitudes, couples were classified into one of four types: (a) main-secondary, (b) coprovider, (c) ambivalent coprovider, and (d) mismatched couples. Nearly half of all spouses differed in their attitudes about breadwinning. A series of mixed model ANCOVAs revealed significant between- and within-couple differences in human capital characteristics, spouses' perceptions of marital satisfaction and role overload, and the division of housework across 3 years of measurement. Coprovider couples reported higher levels of marital satisfaction and a more equitable division of housework than the other couple groups. Wives in the ambivalent coprovider couples' group reported higher levels of role overload than their husbands to a greater extent than was found in the other couple groups. As the first study to adopt a dyadic approach that considers the meanings that both spouses in dual-earner couples ascribe to paid employment, these findings advance understanding of how dual-earner spouses' provider role attitudes serve as contexts for marital quality, behavior, and role-related stress.

  9. Linking perceptions of role stress and incivility to workplace aggression: the moderating role of personality.

    Science.gov (United States)

    Taylor, Shannon G; Kluemper, Donald H

    2012-07-01

    Although research on workplace aggression has long recognized job stressors as antecedents, little is known about the process through which employee responses to stressful workplace demands escalate from relatively mild interactions into more intense behaviors. This study investigates the influence that employees' perceptions of role stress (ambiguity, conflict, overload) have on their aggressive behavior by affecting their perceptions of incivility, and whether these downstream effects depend on personality traits (neuroticism, agreeableness, conscientiousness). Results supported moderated mediation, such that the indirect effects of perceived role ambiguity and role conflict on enacted aggression through experienced incivility varied according to individual differences in personality.

  10. Sex-role identification and violent victimization: gender differences in the role of masculinity.

    Science.gov (United States)

    Daigle, Leah E; Mummert, Sadie J

    2014-01-01

    Although sex-role identification has been found to be associated with crime and delinquency, the link between sex-role identification and violent victimization has remained largely unexplored. Using the Add Health data, this study examines sex-role identification and its relationship to violent victimization. The findings suggest that masculinity increases the risk of violent victimization for males, but does not for females. Other differences in risk factors across gender were also found. These findings indicate that masculinity is an important construct in understanding the complexity of why some persons are violently victimized and others are not.

  11. Androgens in pregnancy: roles in parturition

    Science.gov (United States)

    Makieva, Sofia; Saunders, Philippa T.K.; Norman, Jane E.

    2014-01-01

    BACKGROUND Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterus (i) retains the fetus in utero during pregnancy without initiating stretch-induced contractions and (ii) is able to dilate the cervix and contract the myometrium at term to deliver the fetus. The onset of labour is associated with successful cervical remodelling and contraction of myometrium, arising from concomitant activation of uterine immune and endocrine systems. A large body of evidence suggests that actions of local steroid hormones may drive changes occurring in the uterine microenvironment at term. Although there have been a number of studies considering the potential role(s) played by progesterone and estrogen at the time of parturition, the bio-availability and effects of androgens during pregnancy have received less scrutiny. The aim of this review is to highlight potential roles of androgens in the biology of pregnancy and parturition. METHODS A review of published literature was performed to address (i) androgen concentrations, including biosynthesis and clearance, in maternal and fetal compartments throughout gestation, (ii) associations of androgen concentrations with adverse pregnancy outcomes, (iii) the role of androgens in the physiology of cervical remodelling and finally (iv) the role of androgens in the physiology of myometrial function including any impact on contractility. RESULTS Some, but not all, androgens increase throughout gestation in maternal circulation. The effects of this increase are not fully understood; however, evidence suggests that increased androgens might regulate key processes during pregnancy and parturition. For example, androgens are believed to be critical for cervical remodelling at term, in particular cervical ripening, via regulation of cervical collagen fibril organization. Additionally, a number of studies highlight

  12. An Analysis of Role Stress among Hospital Nurses.

    Science.gov (United States)

    Vredenburgh, Donald J.; Trinkaus, Robert J.

    1983-01-01

    Using a sample of 566 nurses, this study focused on role stress, conceptualized in terms of role conflict, uncertainty about acceptance of one's behavior by supervisors and peers, and role ambiguity. Results indicated that individual attributes, including education, locus of control, and professional commitment, predicted role stress. (Author/RC)

  13. The Managerial Roles of Community College Chief Academic Officers.

    Science.gov (United States)

    Anderson, Philip Wayne

    This study utilized Mintzberg's taxonomy of managerial roles to examine the roles performed by community college chief academic officers (CAOs). Mintzberg's taxonomy defines managerial roles as a set of behaviors and identifies 10 distinct roles: (1) figurehead; (2) leader; (3) liaison; (4) monitor; (5) disseminator; (6) spokesperson; (7)…

  14. Parents or Pop Culture? Children's Heroes and Role Models.

    Science.gov (United States)

    Anderson, Kristin J.; Cavallaro, Donna

    2002-01-01

    Examines the impact of mass media on children's choices of heroes and role models. Addresses questions of which cultural messages children attend to, whether role models vary according to ethnicity and gender, and the role played by educators in exposing children to previously unconsidered role models. (DLH)

  15. Theoretical review and framework : The roles of controllers

    NARCIS (Netherlands)

    Rouwelaar, ten J.A. (Hans)

    2007-01-01

    In the last decades, the position of the business unit controller has grown in importance. This study gives a review of the research behind the two roles, which business unit-controllers can fulfill in business life: the support role and the control role. The support role is associated with

  16. Defining Role-Playing Games as Language-Games

    OpenAIRE

    Arjoranta, Jonne

    2011-01-01

    Role-playing games are a diverse phenomenon, ranging from digital games to live action role-playing. Finding a definition that suits them all is hard, but attempts have been many. All of the definitions emphasize some aspects of role-playing games like rules, the role of players or the story. Many definitions do not describe role-playing games as such, but the activity that is role-playing. This paper looks at one of the latest attempts to define role-playing games, by Hitchens an...

  17. Architects: gender-role and hiring decisions.

    Science.gov (United States)

    Devlin, A S

    1997-10-01

    To examine architects' judgments of male and female applicants represented by the information in resumés, 204 architects, 156 men and 48 women, licensed in the state of Connecticut participated in a 2(job level) by 2(sex) between-subjects study. Architects were asked how they would rate applicants' potential (including the decision to hire) and gender-role characteristics judged on the basis of one-page resumés. Architects randomly assigned resumés for one of four evaluation conditions (intern or senior architect; male or female), rated the applicant on seven job-related characteristics, e.g., technical skill, potential for advancement, and completed the Bem Sex-role Inventory as they thought items applied to the applicant. Analysis indicated that male architect respondents were more likely to hire male applicants than female applicants as senior architects and that female applicants were judged to be as masculine-typed as were male applicants.

  18. Endometriosis: a role for stem cells.

    Science.gov (United States)

    Dhesi, Amy S; Morelli, Sara S

    2015-01-01

    Endometriosis is a complex gynecologic condition affecting 6-10% of reproductive aged women and is a major cause of chronic pain and infertility. Mechanisms of disease pathogenesis are poorly understood. Considerable evidence supports the existence of a stem cell population in the endometrium which provides a physiologic source of regenerative endometrial cells, and multiple lines of evidence now support a key role for stem cells in the pathogenesis of endometriosis. In addition, new blood vessel formation is critical for the establishment and maintenance of endometriotic implants, a process in which endothelial progenitor cells may play an integral role. These new insights into disease pathogenesis present exciting opportunities to develop targeted and more effective therapeutic options in the management of this common and challenging disease.

  19. Wikipedia : its reliability and social role

    Science.gov (United States)

    Kusaka, Kyuhachi

    This article discusses Japanese Wikipedia's reliability and its social role as a free, collaborative, multilingual Internet encyclopedia supported by the non-profit Wikimedia Foundation. Japanese Wikipedia's reliability is explained from several surveys. The central concern is how the nature of encyclopedia and Wikipedia affects the quality of Wikipedia's articles. Wikipedia's core content policies such as verifiability, no original research and a neutral point of view will make articles better. But incomplete or poorly written first drafts exist because Wikipedia is a work in progress. The article also argues that social role of online encyclopedia which provides knowledge for all. Knowledge-based society or/and advanced information society require public understanding of science and other expertise. Online encyclopedia attributed to a reliable, published source using an inline citation will guide anyone to specialized knowledge.

  20. Role of Intermediate Filaments in Vesicular Traffic

    Directory of Open Access Journals (Sweden)

    Azzurra Margiotta

    2016-04-01

    Full Text Available Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway.

  1. Multiple roles of graphene in heterogeneous catalysis.

    Science.gov (United States)

    Fan, Xiaobin; Zhang, Guoliang; Zhang, Fengbao

    2015-05-21

    Scientific interest in graphene as a catalyst and as a catalyst support in heterogeneous catalytic reactions has grown dramatically over the past several years. The present critical review summarizes the multiple roles of graphene in heterogeneous catalysis and highlights the influence of defects, heteroatom-containing functionalities, and graphene's two-dimensional structure on catalytic performance. We first discuss the role and advantages of graphene as a catalyst support, with emphasis on its interactions with the catalytic phases and the influence of mass transfer processes. We then clarify the origin of the intrinsic catalytic activity of graphene in heterogeneous catalytic reactions. Finally we suggest challenges and potential practical applications for graphene in industrial processes.

  2. Role of Ombudsman Institution over the administration

    Directory of Open Access Journals (Sweden)

    Mirlinda Batalli

    2015-11-01

    Full Text Available The purpose of this article is to review the role of Ombudsman institution in increasing the accountability, efficiency, transparency in public administration and promoting a higher level on protection of human rights. The article analysis that ombudsmen have become a crucial part of the political, social and legal actuality in different countries of the world. As a dedicated institution on protecting citizens’ rights, an Ombudsman can be considered as a mechanism to promote democracy, civil rights, rule of law, reforms in public administration and combat maladministration. This paper discusses two particular issues: the concept of Ombudsman institution in general and its role in promoting good administration and governance. By doing so, it raises a multilevel argument for more transparency, effectiveness and accountability in the work of public administration.

  3. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    PURPOSE: Anticipation (ie, an earlier age at onset in successive generations) is linked to repeat expansion in neurodegenerative syndromes, whereas its role in hereditary cancer is unclear. We assessed anticipation in Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), in which DNA...... mismatch repair (MMR) defects cause early and accelerated tumor development with a broad tumor spectrum. PATIENTS AND METHODS: In the population-based Danish HNPCC registry, 407 MMR gene mutation carriers who had developed cancer associated with Lynch syndrome, were identified. These individuals formed 290...... parent-child pairs in which age at the first cancer diagnosis was assessed. A paired t-test and a specifically developed bivariate model were used to assess a possible role of anticipation. RESULTS: Both methods revealed anticipation with children developing cancer mean 9.8 years (P

  4. Nuclear roles for cilia-associated proteins.

    Science.gov (United States)

    McClure-Begley, Tristan D; Klymkowsky, Michael W

    2017-01-01

    Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the ciliary gate, the molecular complex that mediates the selective molecular movement between cytoplasmic and ciliary compartments, shares features with nuclear pores. Our hypothesis is that this shared transport machinery is at least partially responsible for the observation that a number of ciliary and ciliogenesis-associated proteins are found within nuclei where they play roles in the regulation of gene expression, DNA repair, and nuclear import and export. Recognizing the potential for such nuclear roles is critical when considering the phenotypic effects that arise from the mutational modification of ciliary proteins.

  5. The role of ADAMs in disease pathophysiology.

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2012-02-01

    The ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy and asthma.

  6. Exploring IT roles in business process innovation

    DEFF Research Database (Denmark)

    Gong, Jie; Møller, Charles

    2013-01-01

    This paper explores the relationships between IT and Business process innovation (BPI) through examining IT roles in the processes of BPI. BPI is an innovative activity in business which has been paying more attention in recent years. However it is often confused with other process......-orientation concepts, such as Business process management (BPM) and Business process reengineering (BPR). The paper aims to find out two research questions: 1) How do we understand the meanings of BPI in the current background of economic globalization? 2) What IT roles are in the process of BPI? Based on finding...... the answer to these two questions, the definition of BPI in academia and the relationships with other popular process-orientation activities in practice are reviewed, then a framework of comprehensive understanding of BPI is put forward, and thereafter the interactions between IT and BPI are explored...

  7. Role of extracellular vesicles in rheumatoid arthritis.

    Science.gov (United States)

    Fu, Haitao; Hu, Die; Zhang, Licheng; Tang, Peifu

    2018-01-01

    Cell-derived extracellular vesicles (EVs) are involved in the pathogenesis of rheumatoid arthritis (RA), playing important roles in antigen presentation, inflammation, angiogenesis, cell-cell signal communication, thrombosis, and articular cartilage extracellular matrix degradation. Understanding the pathogenic mechanism of RA is important for developing therapies. The pathogenic indicators of RA, such as submicron-sized EVs, represent promising biomarkers for evaluating RA activity. This review summarizes the recent advances in understanding the pathogenesis of RA, and sheds light on the pathogenic as well as anti-inflammatory or immunosuppressive roles of EVs. We suggest that EVs could be harnessed as tools for drug delivery or targets for RA therapies. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Unraveling the role of Mg(++) in osteoarthritis.

    Science.gov (United States)

    Li, Yaqiang; Yue, Jiaji; Yang, Chunxi

    2016-02-15

    Mg(++) is widely involved in human physiological processes that may play key roles in the generation and progression of diseases. Osteoarthritis (OA) is a complex joint disorder characterized by articular cartilage degradation, abnormal mineralization and inflammation. Magnesium deficiency is considered to be a major risk factor for OA development and progression. Magnesium deficiency is active in several pathways that have been implicated in OA, including increased inflammatory mediators, cartilage damage, defective chondrocyte biosynthesis, aberrant calcification and a weakened effect of analgesics. Abundant in vitro and in vivo evidence in animal models now suggests that the nutritional supplementation or local infiltration of Mg(++) represent effective therapies for OA. The goal of this review is to summarize the current understanding of the role of Mg(++) in OA with particular emphasis on the related molecular mechanisms involved in OA progression. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. The Greening Role of Tour Operators

    Science.gov (United States)

    Lozano, Javier; Arbulú, Italo; Rey-Maquieira, Javier

    2016-01-01

    This paper shows that the tour operators (TOs) can play a coordinating role in the adoption of environmental management upstream the tourism supply chain. This is done using a dynamic model to analyze the environmental management adoption by hotels in a tourism destination induced by a TO. The TO can create incentives to greening hotels' management through the sharing of an environmental price premium. We show that the extent of green management adoption depends on interest rate, the willingness to pay for environmental quality, and hotels' organizational inertia. We also show how the financial yields from green management are shared between TOs and hotels. Finally, we consider a destination manager that subsidizes hotels' green management. If the destination manager does not take the greening role of TOs into account, she could mistake the true trade-off that she faces between the destination's economic and environmental outcomes for the win-win setting that characterizes the general problem.

  10. The role of nitric oxide in reproduction

    Directory of Open Access Journals (Sweden)

    McCann S.M.

    1999-01-01

    Full Text Available Nitric oxide (NO plays a crucial role in reproduction at every level in the organism. In the brain, it activates the release of luteinizing hormone-releasing hormone (LHRH. The axons of the LHRH neurons project to the mating centers in the brain stem and by afferent pathways evoke the lordosis reflex in female rats. In males, there is activation of NOergic terminals that release NO in the corpora cavernosa penis to induce erection by generation of cyclic guanosine monophosphate (cGMP. NO also activates the release of LHRH which reaches the pituitary and activates the release of gonadotropins by activating neural NO synthase (nNOS in the pituitary gland. In the gonad, NO plays an important role in inducing ovulation and in causing luteolysis, whereas in the reproductive tract, it relaxes uterine muscle via cGMP and constricts it via prostaglandins (PG.

  11. Experiencing the role of PBL tutor.

    Science.gov (United States)

    Lyberg-Åhlander, Viveka; Lundskog, Margareta; Hansson, Kristina

    2014-01-01

    The tutor is important for student learning in the PBL group. The students expect the tutor to monitor and steer the group process and to support the learning process, helping students to become aware of their own learning. This study aimed at investigating the PBL tutor's role. Five PBL tutors at the Speech/Language Pathology program were interviewed regarding their view of the tutors' role and what support they need. The analysis of the transcribed interviews focused on finding patterns and variation regarding tutor-activity at different stages in the PBL work and in their views of their progress as tutors. The results indicate that being a tutor is a balancing act and that the tutor need continuous support and input from different sources. Tutors should be encouraged to reflect on their own reactions and interventions and to be explicit and confident in their thoughts about PBL.

  12. The Role of Emotions in Delusion Formation

    Directory of Open Access Journals (Sweden)

    Smurzyńska Adrianna

    2016-12-01

    Full Text Available The text concerns the role of emotions in delusion formation. Provided are definitions from DSM-V and DSM-IV-R and the problems found in those definitions. One of them, the problem of delusion formation, is described when providing cognitive theories of delusions. The core of the paper is a presentation of the emotional and affective disorders in delusions, especially Capgras delusion and Cotard delusion. The author provides a comparison of the kinds of delusions and the conclusions taken from neuroimaging studies. As a result of the fact that an explanation of delusion formation focusing on emotional problems turns out to be insufficient, the author provides examples of the reasoning impairments which coexist with them. At the end of the article, some hypotheses are proposed concerning the role of emotions and reasoning in delusion formation and the relation between belief disorders and emotional disorders.

  13. The Role of Calprotectin in Pediatric Disease

    Directory of Open Access Journals (Sweden)

    George Vaos

    2013-01-01

    Full Text Available Calprotectin (CP is a calcium- and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. The aim of the current review is to summarize the latest findings concerning the role of CP in a diverse range of inflammatory and noninflammatory conditions among children. Increasing evidence suggests the implication of CP in the diagnosis, followup, assessment of relapses, and response to treatment in pediatric pathological conditions, such as inflammatory bowel disease, necrotizing enterocolitis, celiac disease, intestinal cystic fibrosis, acute appendicitis, juvenile idiopathic arthritis, Kawasaki disease, polymyositis-dermatomyositis, glomerulonephritis, IgA nephropathy, malaria, HIV infection, hyperzincemia and hypercalprotectinemia, and cancer. Further studies are required to provide insights into the actual role of CP in these pathological processes in pediatrics.

  14. Role of metalloproteinases in rotator cuff tear.

    Science.gov (United States)

    Garofalo, Raffaele; Cesari, Eugenio; Vinci, Enzo; Castagna, Alessandro

    2011-09-01

    The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPS) in the pathophysiology of rotator cuff tears has not been established yet. Recent advances empathize about the role of MMPs and TIMPS in extracellular matrix (ECM) remodeling and degradation in rotator cuff tears pathogenesis and healing after surgical repair. An increase in MMPs synthesis and the resulting MMPs mediated alterations in the ECM of tendons have been implicated in the etiopathogenesis of tendinopathy, and there is an increase in the expression of MMPs and a decrease in TIMP messenger ribonucleic acid expression in tenocytes from degenerative or ruptured tendons. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and bisphosphonates. A better understanding of relationship and activity of these molecules could provide better strategies to optimize outcomes of rotator cuff therapy.

  15. Role conflict in occupational therapy student parents.

    Science.gov (United States)

    Menks, F A; Tupper, L C

    1987-01-01

    Surveys were conducted of occupational therapy curricula and of student parents who had a child or children less than 18 years old living with them. This was done to gather demographic data, to assess students' level of involvement in student and professional activities, to examine extent and sources of role conflict and potential support systems, and to identify curricular modifications that might be helpful in attracting and retaining these students. Of 5165 occupational therapy students, 8.2% were identified as being parents of children less than 18 years old who were living with them. The curricula survey indicated a generally positive attitude towards these nontraditional students. Both the curricula respondents and student respondents indicated that additional resources in the areas of financial support, child care, support groups, and flexible part-time enrollment were needed. Students' responses to the 15 role conflict situations revealed many good problem solving skills and adaptations.

  16. The Role of PPARs in Cancer

    Directory of Open Access Journals (Sweden)

    Keisuke Tachibana

    2008-01-01

    Full Text Available Peroxisome proliferator-activated receptors (PPARs are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR is mainly expressed in the liver, where it activates fatty acid catabolism. PPAR activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride and elevation of high-density lipoprotein cholesterol. PPAR is expressed ubiquitously and is implicated in fatty acid oxidation and keratinocyte differentiation. PPAR activators have been proposed for the treatment of metabolic disease. PPAR2 is expressed exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation. PPAR is involved in glucose metabolism through the improvement of insulin sensitivity and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular targets for the development of drugs treating metabolic syndrome. However, PPARs also play a role in the regulation of cancer cell growth. Here, we review the function of PPARs in tumor growth.

  17. The different roles of the Staff association

    CERN Document Server

    Staff Association

    2012-01-01

    The statutory role of the CERN Staff Association is defined in Chapter VII of the Staff Rules and Regulations. The means of the Association to realize its aims are described in Article I.1.3 of the Statutes of the CERN Staff Association. Generally speaking, its aims are “To serve and defend the economic, social, professional and moral interests of its members and all CERN staff“. Usually we deal with professional and social issues (employment conditions, defence of collective or individual rights, promotion of basic research...). But the Association also plays a role of integration (clubs promoting cultural, humanitarian, and sport or offering entertainment, organizing exhibitions and conferences) and it can promote actions to provide its members with material or social advantages (Interfon, commercial offers). Advantageous commercial offers In recent years the Association was able to negotiate with business or cultural partners benefits for its members. A full list can be found on our...

  18. The Role of Diet in Dermatological Diseases

    Directory of Open Access Journals (Sweden)

    Ahu Yorulmaz

    2014-03-01

    Full Text Available Like other living organisms, humans also depend upon foods in order to maintain their life. Serving as a source of energy, foods are not only crucial for our survival, but also they give pleasure to our sense of taste. There are so many disease fighting foods that are proven to prevent and cure illnesses like cancer, diabetes, osteoporosis, heart attack, and infections. On the other hand, foods can also play role in the development of some kind of illnesses. Dermatitis herpetiformis is the prototypic dermatological disease that there are certain data indicating foods have a definite role in its etiopathogenesis. Atopic dermatitis, psoriasis, pemphigus, acne, allergic contact dermatitis and urticaria are the other dermatological diseases that foods are implicated in their development. In this review, we discussed the etiopathogenesis and relation of foods with the development of most common diseases in dermatological practice.

  19. Emerging role of Vitamin D in health

    Directory of Open Access Journals (Sweden)

    Deepanjali Lomte

    2014-03-01

    Full Text Available Vit. D is a steroid prohormone. It is synthesized in the skin under ultra –violet light exposure. Traditionally, Vit.D3, cholecalciferol and calcitriol were known to have a role only in calcium and bone mineral metabolism. This article takes an account of the current view on the impact of Vit D deficiency on human health. Research has now shown the indisputable role of Vit D in prevention/treatment of some cancers, osteoporosis, rheumatoid arthritis, multiple sclerosis, tuberculosis, hypertension, and diabetes mellitus. In addition lower maternal Vit. D levels are associated with Pregnancy Induced Hypertension (PIH, suggesting that Vit. D deficiency may be a modifiable risk factor for PIH. Greater awareness of the problem of a high prevalence of vitamin D inadequacy is required among researchers, clinicians, and patients. Special efforts on the medical and social fronts are nec­essary to combat this preventable epidemic of vitamin D deficiency.

  20. Neuroprotective Role of Nanoparticles Against Alzheimer's Disease.

    Science.gov (United States)

    Obulesu, Magisetty; Jhansilakshmi, Magisetty

    2016-01-01

    Alzheimer's disease (AD) is a devastative neurodegenerative disorder with a complex etiology. Despite numerous novel nanotechnology methods targeted against cancer and neurodegenerative diseases such as AD in the past decade, several challenges impeded their success. We ventured to circumvent these challenges by synthesizing redox nanoparticles (RNP) such as Nitroxide radical, 2,2,6,6 tetramethylpiperidinyl-N-oxyl (TEMPO). Piperine in association with RNP successfully scavenges reactive oxygen species (ROS). Our studies have also shown that the piperine associated with RNP confers enhanced protection against AD in vitro. This review summarizes our recent findings on the protective roles of redox nanoparticles both in vitro and in vivo. In addition, vital role of nanoparticles employed to encapsulate natural compounds such as curcumin and metal chelators has been summarized. We warrant further studies in animal models using these protective nanoparticles.

  1. The role of prolactin in prostatic inflammation

    Directory of Open Access Journals (Sweden)

    Edson João da Silva

    2013-12-01

    Full Text Available Several reports have shown that prolactin (PRL plays a role in prostatic growth, but few studies considered the role of PRL in the process of prostatic inflammation. Young (45 ± 5 days old and adult (75 ± 5 days old male Wistar rats were subcutaneously injected daily with domperidone (4.0 mg.kg-1 to maintain high serum PRL levels. The animals were treated for 15, 30, 45 or 60 days. Blood and prostate samples were collected at the end of each treatment for PRL dosage and histological analysis, respectively. Only young animals treated with DOMP for 15 and 30 days displayed inflammatory infiltrate in the prostate. These results confirm literature data in regards to PRL involvement in inducing prostate inflammation. Moreover, it was concluded that young animals are more susceptible then adults to the PRL action concerning prostate inflammation.

  2. [Role of surgery in metastatic breast cancer].

    Science.gov (United States)

    Medina-Franco, Heriberto; Suárez-Bobadilla, Yoli Lizbeth

    2012-01-01

    Breast cancer is the most common malignant tumor in Mexican women and very often patients present with advanced stages. Patients with metastatic breast cancer have limited therapeutic options and the mainstay of treatment in this disease stage is systemic chemotherapy Traditionally, the role of surgery in this context is limited to symptom palliation. The increase in efficiency of chemotherapy drugs and the new endocrine and molecular targeted therapy has prolonged the life expectancy of this group of patients and has expanded surgical indications beyond palliation. Some recent institutional reports suggest increasing survival of patients who undergo resection of limited metastatic disease. On another hand, there are reports of survival benefit when the primary tumor is removed even in presence of metastatic disease. We conducted a systematic review of the literature with the objective to analyze the role of surgery in the multidisciplinary management of metastatic breast cancer in order to improve the prognosis of this increasing group of patients.

  3. Role of quercetin in cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Dr. Deepak Kumar Rai

    2008-01-01

    Full Text Available Cardiovascular disease constitutes a major public health concern in industrialized nations. Over recent decades, a large body of evidence has accumulated indicating that oxidative stress induced free radicals play a critical role in cellular processes implicated in atherosclerosis and many other heart diseases. However a diet high in antioxidants is associated with a reduced risk of cardiovascular disease. The compound quercetin is a dietary antioxidant with a polyphenolic structure that is present in many foods, such as onion, apples, wine and tea. An increased intake of quercetin has been correlated with a decrease in the risk of cardiovascular diseases. Quercetin has been reported to exhibit a wide range of biological and pharmacological effects in animals and man besides its antioxidative and free radical scavenging actions. This paper reviews various steps of oxidative stress mediated atherogenesis and their signaling pathways and also emphasizes the role of quercetin in controlling oxidative stress and reducing the incidence of cardiovascular diseases.

  4. The Role of Cardiolipin in Cardiovascular Health.

    Science.gov (United States)

    Shen, Zheni; Ye, Cunqi; McCain, Keanna; Greenberg, Miriam L

    2015-01-01

    Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health.

  5. The Role of Cardiolipin in Cardiovascular Health

    Directory of Open Access Journals (Sweden)

    Zheni Shen

    2015-01-01

    Full Text Available Cardiolipin (CL, the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS, which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs, including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health.

  6. Regulation and Role of Fungal Secondary Metabolites.

    Science.gov (United States)

    Macheleidt, Juliane; Mattern, Derek J; Fischer, Juliane; Netzker, Tina; Weber, Jakob; Schroeckh, Volker; Valiante, Vito; Brakhage, Axel A

    2016-11-23

    Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication signals during coexistence with other microorganisms, virulence factors during pathogenic interactions with plants and animals, and in medical applications. Therefore, research on this topic has intensified significantly during the past 10 years and thus knowledge of regulatory mechanisms and the understanding of the role of secondary metabolites have drastically increased. This review aims to depict the complexity of all the regulatory elements involved in controlling the expression of secondary metabolite gene clusters, ranging from epigenetic control and signal transduction pathways to global and specific transcriptional regulators. Furthermore, we give a short overview on the role of secondary metabolites, focusing on the interaction with other microorganisms in the environment as well as on pathogenic relationships.

  7. Role of QCD monopoles in jet quenching

    Science.gov (United States)

    Ramamurti, Adith; Shuryak, Edward

    2018-01-01

    QCD monopoles are magnetically charged quasiparticles whose Bose-Einstein condensation (BEC) at T T >Tc is responsible for the unusual kinetic properties of quark-gluon plasma. In this paper, we study the contribution of the monopoles to jet quenching phenomenon, using the Baier-Dokshitzer-Mueller-Peigne-Schiff framework and hydrodynamic backgrounds. In the lowest order for cross sections, we calculate the nuclear modification factor, RAA, and azimuthal anisotropy, v2, of jets, as well as the dijet asymmetry, Aj, and compare those to the available data. We find relatively good agreement with experiment when using realistic hydrodynamic backgrounds. In addition, we find that event-by-event fluctuations are not necessary to reproduce RAA and v2 data, but play a role in Aj. Since the monopole-induced effects are maximal at T ≈Tc, we predict that their role should be significantly larger, relative to quarks and gluons, at lower RHIC energies.

  8. Role of Bronchoscopy in Malignant Pleural effusion

    Directory of Open Access Journals (Sweden)

    Gomathi. R. G.

    2016-04-01

    Full Text Available The aim of this study was to assess the role of Bronchoscopy in plural effusion in cancer condition. Pleural effusion is one of the commonest problems with which patients present to the hospital. Around a million patients worldwide develop pleural effusion each year. This is a Prospective and Observational Study. All patients diagnosed to have pleural effusion by xray, clinical examination and ultrasound examination of pleura if needed will undergo informed. All 32 patients underwent bronchoscopy procedure, 30 patients had endobronchial mass and biopsy was done which was positive for malignancy and 2 patients had bronchial wash cytology positive for malignancy We conclude that bronchoscopy has a definite role in the etiological diagnosis of pleural effusion.

  9. A novel functional role of collagen glycosylation

    DEFF Research Database (Denmark)

    Jürgensen, Henrik J; Madsen, Daniel H; Ingvarsen, Signe

    2011-01-01

    Collagens make up the most abundant component of interstitial extracellular matrices and basement membranes. Collagen remodeling is a crucial process in many normal physiological events and in several pathological conditions. Some collagen subtypes contain specific carbohydrate side chains......, the function of which is poorly known. The endocytic collagen receptor urokinase plasminogen activator receptor-associated protein (uPARAP)/Endo180 plays an important role in matrix remodeling through its ability to internalize collagen for lysosomal degradation. uPARAP/Endo180 is a member of the mannose....... The molecular basis for this interaction is known to involve the fibronectin type II domain but nothing is known about the function of the lectin domains in this respect. In this study, we have investigated a possible role of the single active lectin domain of uPARAP/Endo180 in the interaction with collagens...

  10. The Roles of Sketching in Design

    DEFF Research Database (Denmark)

    Vistisen, Peter

    2015-01-01

    This paper examines how the role of sketching in design process has been disseminated previously through a review of prior perspectives into the field. We identify that the studies of design sketching has been dominated by two perspectives: studies into what is known as ‘visual thinking......’ (Goldschmidt 1991, Schön & Wiggins 1992, Tversky et al. 1999), which examines the designers reflective conversation with the sketch, and a second perspective on sketching as way of ‘visual communication’ with others in the design process (Lugt 2005, Schütze 2003, Buxton 2010). We raise the question of whether...... process: investigative, explorative, communicative, and persuasive. We appropriate these categories into a tension field, reflecting how the role of the same sketch may change over the course of time in the design project, based upon the type of knowledge required to gain from the sketch at a given time....

  11. Role of galactose in cellular senescence.

    Science.gov (United States)

    Elzi, David J; Song, Meihua; Shiio, Yuzuru

    2016-01-01

    Cellular senescence has been proposed to play critical roles in tumor suppression and organismal aging, but the molecular mechanism of senescence remains incompletely understood. Here we report that a putative lysosomal carbohydrate efflux transporter, Spinster, induces cellular senescence in human primary fibroblasts. Administration of d-galactose synergistically enhanced Spinster-induced senescence and this synergism required the transporter activity of Spinster. Intracellular d-galactose is metabolized to galactose-1-phosphate by galactokinase. Galactokinase-deficient fibroblasts, which accumulate intracellular d-galactose, displayed increased baseline senescence. Senescence of galactokinase-deficient fibroblasts was further enhanced by d-galactose administration and was diminished by restoration of wild-type galactokinase expression. Silencing galactokinase in normal fibroblasts also induced senescence. These results suggest a role for intracellular galactose in the induction of cellular senescence. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Potential physiological role of plant glycosidase inhibitors

    DEFF Research Database (Denmark)

    Bellincampi, D.; Carmadella, L.; Delcour, J.A.

    2004-01-01

    Carbohydrate-active enzymes including glycosidases, transglycosidases, glycosyltransferases, polysaccharide lyases and carbohydrate esterases are responsible for the enzymatic processing of carbohydrates in plants. A number of carbohydrate-active enzymes are produced by microbial pathogens...... and insects responsible of severe crop losses. Plants have evolved proteinaceous inhibitors to modulate the activity of several of these enzymes. The continuing discovery of new inhibitors indicates that this research area is still unexplored and may lead to new exciting developments. To date, the role...... of the inhibitors is not completely understood. Here we review recent results obtained on the best characterised inhibitors, pointing to their possible biological role in vivo. Results recently obtained with plant transformation technology indicate that this class of inhibitors has potential biotechnological...

  13. Role of PARP-1 in prostate cancer.

    Science.gov (United States)

    Deshmukh, Dhanraj; Qiu, Yun

    2015-01-01

    Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that catalyzes the covalent attachment of polymers of ADP-ribose (PAR) moieties on itself and its target proteins. PARP1 activity is frequently deregulated in various cancers and therefore it has emerged as a new drug target for cancer therapy. The role of PARP-1 in DNA repair has been well documented and BRCA mutations are implicated for determining the sensitivity to PARP inhibitors. Recent studies also point to a role of PARP-1 in transcription regulation which may contribute to oncogenic signaling and cancer progression. Given that efficacy of PARP inhibitors are also seen in patients not harboring BRCA mutations, some other mechanisms might also be involved. In the present review, we highlight the mechanisms by which PARP-1 regulates gene expression in prostate cancer and provide an overview of the ongoing clinical trials using PARP inhibitors in various cancers including prostate cancer.

  14. The Role(s) of Heparan Sulfate Proteoglycan(s) in the wnt-1 Signaling Pathway

    National Research Council Canada - National Science Library

    Lin, Xinhua

    2000-01-01

    .... I have investigated the role of heparan sulfate proteoglycans (HSPGs) in Wg signaling. HSPGs are cell surface macromolecules that consist of a protein core to which heparan sulfate (HS) glycosaminoglycan (GAG...

  15. Personal goals in social roles: divergences and convergences across roles and levels of analysis.

    Science.gov (United States)

    Sheldon, K M; Elliot, A J

    2000-02-01

    Most contemporary personal goal research aggregates across goals, perhaps masking important differences between goals. We assessed this risk by examining both similarities and differences between the goals that participants pursued in five important social roles. Previous relevant findings (Cantor, Norem, Niedenthal, Langston, & Brower, 1987) and self-determination theory (Deci & Ryan, 1985) were used to predict between-role differences in goal appraisal dimensions. Although theoretically meaningful differences were found across child, employee, romantic, friendship, and student goals, and also across within- and between-subject levels of analysis, all goals were essentially the same in one important way: Making longitudinal progress in them predicted positive change in accompanying role-circumstances and role-satisfaction (excepting friendship goals). This indicates that researchers do not necessarily lose information by aggregating, and affirms that goal-attainment is generally desirable.

  16. Role of mitochondrial dysfunction in hyperglycaemia-induced coronary microvascular dysfunction: Protective role of resveratrol.

    Science.gov (United States)

    Joshi, Mandar S; Williams, David; Horlock, Duncan; Samarasinghe, Thilini; Andrews, Karen L; Jefferis, Ann-Maree; Berger, Philip J; Chin-Dusting, Jaye P; Kaye, David M

    2015-05-01

    Microvascular complications are now recognized to play a major role in diabetic complications, and understanding the mechanisms is critical. Endothelial dysfunction occurs early in the course of the development of complications; the precise mechanisms remain poorly understood. Mitochondrial dysfunction may occur in a diabetic rat heart and may act as a source of the oxidative stress. However, the role of endothelial cell-specific mitochondrial dysfunction in diabetic vascular complications is poorly studied. Here, we studied the role of diabetes-induced abnormal endothelial mitochondrial function and the resultant endothelial dysfunction. Understanding the role of endothelial mitochondrial dysfunction in diabetic vasculature is critical in order to develop new therapies. We demonstrate that hyperglycaemia leads to mitochondrial dysfunction in microvascular endothelial cells, and that mitochondrial inhibition induces endothelial dysfunction. Additionally, we show that resveratrol acts as a protective agent; resveratrol-mediated mitochondrial protection may be used to prevent long-term diabetic cardiovascular complications. © The Author(s) 2015.

  17. The roles of clinical psychologists: a comparison of faculty models and student practicuum roles.

    Science.gov (United States)

    Prien, E P; Khanna, P

    1990-07-01

    This article focuses on the definition of faculty education and training models, as compared to student field placement job roles. Both faculty models and student roles are described in terms of tasks and job skills that were judged important. An inverse factor analysis was performed for the task importance judgements, separately for the faculty sample and the student sample. Group membership was used to calculate both task and job skill profiles. Those profiles were compared to determine the similarities and differences between the faculty and student models. Overall, there is a lack of similarity between faculty members' education and training models and student field placement job roles, as identified by the multidomain job analysis technique. One must conclude either that the faculty models represent a developmental view, rather than the current reality as represented by field placement jobs, or that those jobs are artificial roles that are irrelevant insofar as education and training are concerned.

  18. Role for Genetic Anticipation in Lynch Syndrome

    DEFF Research Database (Denmark)

    Nilbert, Mef; Timshel, Susanne; Bernstein, Inge

    2009-01-01

    PURPOSE: Anticipation (ie, an earlier age at onset in successive generations) is linked to repeat expansion in neurodegenerative syndromes, whereas its role in hereditary cancer is unclear. We assessed anticipation in Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), in which DN...... to initiate surveillance programs at young age. It should also stimulate research into the genetic mechanisms that determine age at onset and whether the genetic instability that characterizes Lynch syndrome can be linked to anticipation....

  19. THE ROLE OF LEADERSHIP IN STRATEGIC MANAGEMENT

    OpenAIRE

    Ali Abdulridha Jabbar; Ali Mohammed Hussein

    2017-01-01

    Leadership has significant impact on strategic management process. Especially it helps to determine the vision and mission of the organization. Further, it facilitates the organization to execute effective strategies to achieve that vision. The purpose of this paper is to find out the role of leadership in strategy formulation and implementation by reviewing the existing literature. The study reveals that leadership serves as a link between the soul and the body of an organization. For the su...

  20. The role of vocal individuality in conservation

    DEFF Research Database (Denmark)

    Terry, Andrew Mark Ryder; Peake, Thomas More; McGregor, Peter Kenneth

    2005-01-01

    Identifying the individuals within a population can generate information on life history parameters, generate input data for conservation models, and highlight behavioural traits that may affect management decisions and error or bias within census methods. Individual animals can be discriminated...... and techniques for using this to count and monitor populations over time. We present case studies in birds where vocal individuality has been applied to conservation and we discuss its role in mammals....

  1. Childhood Obesity: A Role for Gut Microbiota?

    OpenAIRE

    Marina Sanchez; Shirin Panahi; Angelo Tremblay

    2014-01-01

    Obesity is a serious public health issue affecting both children and adults. Prevention and management of obesity is proposed to begin in childhood when environmental factors exert a long-term effect on the risk for obesity in adulthood. Thus, identifying modifiable factors may help to reduce this risk. Recent evidence suggests that gut microbiota is involved in the control of body weight, energy homeostasis and inflammation and thus, plays a role in the pathophysiology of obesity. Prebiotic...

  2. Role of logic programming in computer studies

    Directory of Open Access Journals (Sweden)

    Nicolae PELIN

    2016-09-01

    Full Text Available The paper contains the analysis of the opinions of a number of scholars and specialists on the importance and the role in logic programming methodology of studying computer science, philosophy about the logic programs and interpreter, concerning the burden of which is opposite to the programmer if there is logic interpreter. The presented material is meant, according to the author, to help the reader to understand more easily the analyzed multilateral problem.

  3. The role of immune system in autism

    OpenAIRE

    Niederlová, Veronika

    2015-01-01

    Autism is a complex neurodevelopmental disorder with yet unknown etiology. The research point out abnormalities in the immune system of pacients with autism, which could be related to the development of the disease. This thesis reviews current scientific knowledge about the role of the immune system in the development of autism. The leading chapters include family history of autoimmune diseases, specific HLA alleles, the most common autoantibodies and maternal antibodies, lowered NK cell acti...

  4. The Role of Attachment Functions in Psychotherapy

    OpenAIRE

    Spiegel, Jeremy; Severino, Sally K.; Morrison, Nancy K.

    2000-01-01

    The authors propose to clarify concepts of emotional attunement and failures of attunement in early development derived from theoretical and clinical work (Kohut) and infant psychiatry (Stern). Early attunement failures are experienced as shameful by the infant/child, and without repair they form a nidus for later destructive adult interpersonal relationships, “social blindness,” and depression. The authors present a case illustrating these ideas. The role of empathic attunement experienced i...

  5. Changing Family Roles - Across the Deployment Cycle

    Science.gov (United States)

    2017-09-01

    on the impact of technology-based communication during deployment on later psychological distress and role functioning. PROGRESS TO DATE...higher levels of warmth and lower levels of agonism also reported lower levels of externalizing behavior in their children. When at-home partners...reported their children’s relationship changed over the course of the study, so did their reports of externalizing behavior in their children. 15. SUBJECT

  6. Leadership Roles in Standards and Policy Development.

    Science.gov (United States)

    Bleich, Michael R

    2017-05-01

    Leaders are defined by traits, behaviors, roles, and functions, yet little is described about their responsibilities linked to standards and policy development. Presented in this article is a four-point organizational framework (primary, procedural, population-specific, and public) that is useful for establishing patient, institutional, and public policies central to leadership. Leader responsibility for communicating minimum standards is contrasted with setting optimal practice expectations. J Contin Educ Nurs. 2017;48(5):203-205. Copyright 2017, SLACK Incorporated.

  7. Role of nitric oxide in cancer biology.

    Science.gov (United States)

    Moochhala, S; Rajnakova, A

    1999-12-01

    The role of nitric oxide (NO) in tumorigenesis is multifactorial. NO can participate in the complicated process of carcinogenesis by mediating DNA damage in early phases of tumorigenesis, as well as support tumor progression through the induction of angiogenesis and suppression of the immune response. This paper addresses the effects of NO on transcriptional regulation following DNA damage and cyclooxygenase expression in the multistep process of tumorigenesis.

  8. Interprofessional Care and Role of Team Leaders

    OpenAIRE

    Bachchu Kailash Kaini

    2015-01-01

    Interprofessional care is an essential part of the health service delivery system. It helps to achieve improved care and to deliver the optimal and desired health outcomes by working together, sharing and learning skills. Health care organisation is a collective sum of many leaders and followers. Successful delivery of interprofessional care relies on the contribution of interprofessional care team leaders and health care professionals from all groups. The role of the interprofessional care t...

  9. Tutor roles in collaborative group work

    OpenAIRE

    Boylan, Mark; Smith, Peter

    2012-01-01

    Collaborative assessed group work can create challenges for both students and tutors. Both the benefits and challenges of assessed group work are discussed with particular reference to the context of teacher education. The relevance of action research, the concept of living theory and the ethical nature of tutor practice in relation to group work are considered. The concept of 'role' is used to analyse aspects of tutor practice based on outcomes from an extended process of action research. A ...

  10. Role of bacterial infections in pancreatic cancer

    OpenAIRE

    Michaud, Dominique S.

    2013-01-01

    Established risk factors for pancreatic cancer, including tobacco smoking, chronic pancreatitis, obesity and type 2 diabetes, collectively account for less than half of all pancreatic cancer cases. Inflammation plays a key role in pancreatic carcinogenesis, but it is unclear what causes local inflammation, other than pancreatitis. Epidemiological data suggest that Helicobacter pylori may be a risk factor for pancreatic cancer, and more recently, data suggest that periodontal disease, and Porp...

  11. Acupuncture for Refractory Epilepsy: Role of Thalamus

    OpenAIRE

    Chen, Shuping; Wang, Shubin; Rong, Peijing; Liu, Junling; Zhang, Hongqi; Zhang, Jianliang

    2014-01-01

    Neurostimulation procedures like vagus nerve stimulation (VNS) and deep brain stimulation have been used to treat refractory epilepsy and other neurological disorders. While holding promise, they are invasive interventions with serious complications and adverse effects. Moreover, their efficacies are modest with less seizure free. Acupuncture is a simple, safe, and effective traditional healing modality for a wide range of diseases including pain and epilepsy. Thalamus takes critical role in ...

  12. REDEFINING GENDER ROLES WITHIN CONTEMPORARY RURAL FAMILY

    OpenAIRE

    Iorga, Adina Magdalena

    2014-01-01

    The social construction of gender (male and female) is crucial in analyzing gender roles in rural family .Social interpretation of biological sex leads to identifying a set of gender related behaviors observable in both private and public life of an individual. The aim of this research is to identify the opinion of students at University of Agronomic Sciences and Veterinary Medicine, Bucharest, regarding gender perception, gender characteristics, and gender equality in both private and public...

  13. Employee engagement: The role of psychological conditions

    OpenAIRE

    Rothmann, Sebastiaan; Welsh, Coen

    2013-01-01

    The purpose of this study was to investigate the antecedents of employee engagement in the context of a developing country. A cross-sectional survey design was used with a sample of 309 employees in organisations in Namibia. A biographical questionnaire and questionnaires that measure employee engagement and antecedents of engagement were administered. Work-role fit and job enrichment showed the strongest relationships with employee engagement, while rewards, co-worker relations, resources, s...

  14. The Role of Motivation in Language Learning

    OpenAIRE

    Rahman, Anwar

    2011-01-01

    The mastery of English learning is influenced by some variables, one of them is motivation. Motivation in learning second language is classified as integrative motivation and instrumental motivation. Some experts of language teaching also categorized motivation into two types namely intrinsic motivation and extrinsic motivation. This paper discusses about kinds of motivation and how it takes a role in influencing students mastery in learning language. It was literature study that focused to f...

  15. Role of Achara Rasayana in Chittodvega

    OpenAIRE

    Babu, G; Bhuyan, G. C.; Prasad, G.P.; Mrs. S. Anitha

    2007-01-01

    Ayuveda “the science of life” deals with various dimensions of human being. In this age old science, psychological factors have been given equal importance as physiological factors in the etiology of various diseases. Though there are so many rejuvenation therapies, Achara Rasayana is mainly advocated for psychosomatic disorders. Chittodvega (anxiety neurosis) is one among those psychological diseases in which, the code of conduct (Achara Rasayana) plays an important role in both etiology as ...

  16. Enhancing the role of the dairy vet.

    Science.gov (United States)

    2016-09-03

    More than 3000 veterinarians, researchers and industry representatives gathered in Dublin in July for the 29th congress of the World Association for Buiatrics. With the theme of 'Cattle health - tomorrow's thinking today', the programme for the five-day meeting was wide-ranging, exploring issues such as animal health systems, animal welfare initiatives, zoonoses, mastitis control and infectious disease control. Here, Kristy Ebanks focuses on two keynote addresses which considered the evolving role of the dairy vet. British Veterinary Association.

  17. THE ROLE OF INFORMATION TECHNOLOGY IN ORGANIZATIONS

    OpenAIRE

    Ramin Bashir Khodaparasti

    2012-01-01

    Development of organization started in period with agriculture and industrial during the period came and information. Today in period of competition, information is very important needed. So competitive advantage in the information provided to achieve goals is necessary. Entrance of this technology in organizations conjectural attitude changed and evolved functions their managers. The purpose of this paper is to define the correct information and the role technology has in improving the situa...

  18. The software architecture role in agile methodologies

    OpenAIRE

    Anacleto, Valerio Adrián

    2006-01-01

    The software architecture role in agile methodologies is not sufficiently documented or formalized by means of a process consistent with the philosophy. The current work’s contributions are: 1) Defining guidelines to implement architecture practices in an agile way and so that they can be applied independently of the development process in use. 2) Setting the grounds for the definition of an agile architecture process.

  19. A role of leader in creative schools

    Directory of Open Access Journals (Sweden)

    Мария Павловна Калашник

    2017-01-01

    Full Text Available A role of leader in the Jena «romantic school»; Mannheim school, which has prepared the emergence a classical form of symphony; Netherlands school with a main feature – composer's professionalism; Second Viennese School is examined in the article. The authority of these schools in the musical circles, comprehensive impact, fundamental meaning for becoming a composer’s art are marked. The creative, professionally-creative and technological aspect of schools are defined

  20. Role of inflammation in nocturnal asthma.

    OpenAIRE

    MacKay, T. W.; Wallace, W A; Howie, S. E.; Brown, P. H.; Greening, A P; Church, M. K.; Douglas, N. J.

    1994-01-01

    BACKGROUND--Nocturnal airway narrowing is a common problem for patients with asthma but the role of inflammation in its pathogenesis is unclear. Overnight changes in airway inflammatory cell populations were studied in patients with nocturnal asthma and in control normal subjects. METHODS--Bronchoscopies were performed at 0400 hours and 1600 hours in eight healthy subjects and in 10 patients with nocturnal asthma (> 15% overnight fall in peak flow plus at least one awakening/week with asthma)...

  1. The Role of Sketch in Architecture Design

    Science.gov (United States)

    Li, Yanjin; Ning, Wen

    2017-06-01

    With the continuous development of computer technology, we rely more and more on the computer and pay more and more attention to the final design results, so that we ignore the importance of the sketch. However, the sketch is the most basic and effective way of architecture design. Based on the study of the sketch of Tjibao Cultural Center of sketch, the paper explores the role of sketch in architecture design .

  2. Role of Speaker Cues in Attention Inference

    OpenAIRE

    Jin Joo Lee; Cynthia Breazeal; David DeSteno

    2017-01-01

    Current state-of-the-art approaches to emotion recognition primarily focus on modeling the nonverbal expressions of the sole individual without reference to contextual elements such as the co-presence of the partner. In this paper, we demonstrate that the accurate inference of listeners’ social-emotional state of attention depends on accounting for the nonverbal behaviors of their storytelling partner, namely their speaker cues. To gain a deeper understanding of the role of speaker cues in at...

  3. The role of hyaluronic acid in biomineralization

    Science.gov (United States)

    Chen, Zhen-Hua; Ren, Xiu-Li; Zhou, Hui-Hui; Li, Xu-Dong

    2012-12-01

    Hyaluronic acid has been extensively investigated due to intrinsic properties of natural origin and strong ability to bind ions in water. Hyaluronic acid is an excellent crystal modifier because its abundant negatively charged carboxyl groups can bind the cations protruding from the crystal lattice. In this review, we mainly present the latest work focus on the role of hyaluronic acid in controlling the crystallization, breaking the symmetry of crystal, and the surface funtionalization of nanocrystals.

  4. Siderophores in environmental research: roles and applications

    OpenAIRE

    Ahmed, E.; Holmström, S J M

    2014-01-01

    Siderophores are organic compounds with low molecular masses that are produced by microorganisms and plants growing under low iron conditions. The primary function of these compounds is to chelate the ferric iron [Fe(III)] from different terrestrial and aquatic habitats and thereby make it available for microbial and plant cells. Siderophores have received much attention in recent years because of their potential roles and applications in various areas of environmental research. Their signifi...

  5. LEARNING TECHNOLOGY RESEARCH : TEACHERS ROLE IN ICT

    OpenAIRE

    Asha Thokchom

    2013-01-01

    Information Communication Technologies (ICT) are a part of our world and we use them everyday.ICT represents an important source of information about us and others, as well as about local and world events. A nation's economic wellbeing depends on the effective use of ICT. Teachers are important resources for modernization and change in education system. ICT will also require a modification of the role of the teacher, who in addition to class-room teaching will have other skills and responsibi...

  6. The role of magnetic resonance cholangiopancreatography and ...

    African Journals Online (AJOL)

    2017-06-28

    Jun 28, 2017 ... Scan this QR code with your smart phone or mobile device to read online. Authors: Zeynep Cetiner-Alpay1. Fatma Kulali2. Aslihan Semiz-Oysu2. Yasar Bukte2. Kamil Ozdil3. Affiliations: 1Department of Radiology, ... How to cite this article: Cetiner-Alpay Z, Kulali F,. Semiz-Oysu A, Bukte Y,. Ozdil K. The role ...

  7. Leadership Communication Role within International Business Organization

    OpenAIRE

    Křetínská, Tereza

    2014-01-01

    The thesis focuses on the role of leadership communication within a multinational business organization. It aims to confirm the critical importance of communication provided by leaders to their team members. The literature review will focus on the existing communication flows within organizations and the current research results and insights in the field of leadership communication, which is a new, emerging domain of study. Thanks to recent quantitative research (Men, 2014b), it has been alre...

  8. Growing Role of Retail in Distribution Channels

    OpenAIRE

    Ishak Mesic

    2011-01-01

    This article aims to demonstrate the growing role of retail trade (retail) in the channels of distribution of goods both in domestic and international markets. Technical-technological development has provided great opportunities for all production of material goods, so that the focus of problem in the economic possibilities of playing shifted from production to sales opportunities, or consumption. The ultimate consumers and their needs and requirements have become a central area of study, bas...

  9. The role of gender in videogames

    OpenAIRE

    Piedad SAUQUILLO MATEO; Ros Ros, Concepción; Mª Carmen Bellver Moreno

    2017-01-01

    Education for equality requires the involvement of each and every one of the agencies involved in this process. In this work we wanted to know if the most played video games by children and adolescents transmit content that contribute to their education for equality or not. We have analysed the content of the ten most played games by children and adolescents, according to the values and disvalues transmited, focusing our attention on the model representation of women and gender roles. Lastly,...

  10. Japan: Implications of an Expanded Military Role,

    Science.gov (United States)

    1985-07-03

    served by diplomatic, economic and foreign assistance strategies. The Fukuda and Ohira " doctrines " emphasized the role of non-military policy in...encourage it to expand economic assistance under the comprehensive security doctrine . Weinstein is criticizing U.S. policy toward the Soviet Union; he...the United States. The second category of opinion which developed centered -~ on support for a policy line orginally set forth In the Yoshida Doctrine

  11. Changing perspective: The role of vestibular signals

    OpenAIRE

    Deroualle, Diane; Borel, Liliane; Deveze, Arnaud; Lopez, Christophe

    2015-01-01

    Social interactions depend on mechanisms such as the ability to take another person's viewpoint, i.e. visuo-spatial perspective taking. However, little is known about the sensorimotor mechanisms underpinning perspective taking. Because vestibular signals play roles in mental rotation and spatial cognition tasks and because damage to the vestibular cortex can disturb egocentric perspective, vestibular signals stand as important candidates for the sensorimotor foundations of perspective taking....

  12. Global supply chain: The consolidators’ role

    Directory of Open Access Journals (Sweden)

    Rosa Caiazza

    2016-01-01

    Full Text Available Challenges and opportunities of the global market lead agro-food small and medium firms (SMEs to focus their source of value on production of high quality goods and implementation of flexible and robust supply chains. Despite the relevance of consolidators in the supply chain, few articles demonstrate their role in internationalization strategies of SMEs. In order to fill this literature gap, this article shows factors that affect global success of SMEs and offers some advice to decision makers.

  13. The Role of Innovation in Organizational Development

    Science.gov (United States)

    1981-06-01

    group or the climate ( sentience ). Task and Sentient Groups. An important and useful distinction is sometimes drawn between task and sentient groups...roles during the Korean War. Tasks and Team Skills. Although the development of sentience is clearly important to the issue of organizational renewal...taken to foster sentience may interfere with th-e perfor- mance of task groups, it is crucial to maintain the boundaries betwreen them and insure that

  14. Gas/electricity convergence: role of marketers

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, K.G. [Powerex Corp., Inc., Youngwood, PA (United States)

    1997-04-01

    The role of marketers in the convergence of the gas and electricity industry was presented. Topics of discussion included types of convergence, such as wholesale price convergence, BTU convergence, energy information systems service convergence, and corporate convergence. Also discussed was a review of technical, economic, political and regulatory barriers to convergence. Implications for customers, regulators and vertically integrated utilities and trade associations were also assessed.

  15. Serendipity and its role in dermatology

    OpenAIRE

    Arijit Coondoo; Sujata Sengupta

    2015-01-01

    Serendipity is a pleasant surprise of finding a particularly useful information while not looking for it. Significant historic events occurring as a result of serendipity include the discovery of the law of buoyancy (Archimedes principle) by the Greek mathematician Archimedes, of the Americas by Christopher Columbus and of gravity by Sir Isaac Newton. The role of serendipity in science has been immensely beneficial to mankind. A host of important discoveries in medical science owe their origi...

  16. The future role of renewables in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Fouquet, Doerte [Becker Buettner Held, Brussels (Belgium); Nysten, Jana Viktoria [Becker Buettner Held, Berlin (Germany)

    2016-04-01

    Renewable energies have played a large role in the energy policies of the European Union and the Member States over the last ten years. The policy approaches are changing, and the legal framework for the future development of renewable energies in the European Union and the Member States is going to change as well. Current trends and ideas are discussed and some conclusions are drawn on the future framework for renewable energies in the European Union.

  17. Department of Justice Role in Countering WMD

    Energy Technology Data Exchange (ETDEWEB)

    Prosnitz, D

    2004-01-12

    Stopping terrorist is most likely to be accomplished by state, local and federal law enforcement. With the creation of the Department of Homeland Security, the specific roles and responsibilities of the Department of Justice (DOJ) in preventing and responding to weapons of mass destruction (WMD) terrorist attacks are under reversion, but unquestionably the DOJ, as the chief federal law enforcement agency, will continue to have major responsibilities.

  18. Asteroid Evolution: Role of Geotechnical Properties

    Science.gov (United States)

    Sánchez, Paul

    2016-01-01

    This paper presents a brief review and latest results of the work that has been carried out by the Planetary Science community in order to understand the role of the geotechnical properties of granular asteroids (commonly known as ``rubble-pile'' asteroids) in their formation, evolution and possible disruption. As such, we will touch in aspects of the theoretical and numerical tools that have been used with this objective and how the obtained results compare to the observed asteroids.

  19. The role of assistance dogs in society

    OpenAIRE

    Audrestch, Hilary M.; Whelan, Chantelle T.; Grice, David; Asher, Lucy; England, Gary C.W.; Freeman, Sarah L.

    2015-01-01

    Assistance dogs are specially trained to undertake a variety of tasks to help individuals with disabilities. This review gives an overview of the different types of assistance dogs in the UK, including guide dogs, hearing dogs, mobility assistance dogs, service dogs and dual purpose dogs. The literature describes many benefits of assistance dogs, including their impact on physical wellbeing and safety of their ‘owners,’ as well as on psychological wellbeing and social inclusion. The role of a...

  20. Social role effects on gender stereotyping in Germany and Japan

    OpenAIRE

    Steinmetz, Janina; Bosak, Janine; Szczesny, Sabine; Eagly, Alice

    2014-01-01

    Social role theory postulates that gender stereotypes are restrained for men and women observed in the same social role. Cultural differences in the valuation of communal attributes might moderate this effect. To examine this possibility, 288 participants (144 German, 144 Japanese) estimated the communal and agentic attributes of an average man or woman described in a male-dominated role, a female-dominated role, or without role information. We hypothesized and found that in Germany and Ja...

  1. The role of touch in acupuncture treatment.

    Science.gov (United States)

    Chae, Younbyoung; Olausson, Håkan

    2017-04-01

    Acupuncture is a therapeutic treatment that is characterised by the insertion of a needle at a particular location on the body. Acupuncture stimulation includes sensory-discriminative and affective-social touch dimensions. In this review, we discuss the role of touch during acupuncture stimulation with an emphasis on the therapeutic, sensory-discriminative and affective-social aspects. In the discriminative dimension, de qi, which is associated with needling, includes a combination of various sensations, such as heaviness, numbness, soreness and distension. Achieving the appropriate de qi sensation appears to be fundamental to the therapeutic outcome following acupuncture treatment. In the affective dimension, the acupuncture procedure typically includes gentle manual touch stimulation, which induces feelings of calm and well-being, perhaps by activating C tactile fibres. Enhanced activity of C tactile afferents may induce a 'limbic touch' response, resulting in emotional and hormonal reactions. Because acupuncture is a 'therapist intensive' and complex intervention, it is necessary to understand the role of social touch between the practitioner and patient. Both sensory-discriminative and affective-social touch aspects play an important role in the therapeutic effect of acupuncture treatment in clinical practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. The role of chemerin in human disease

    Directory of Open Access Journals (Sweden)

    Magdalena Stojek

    2017-02-01

    Full Text Available Adipose tissue is not merely a storage depot of triacylglycerols but also a major endocrine organ. Its cells, including adipocytes, synthesize and secrete a range of biologically active molecules termed adipokines. Adipokines that display the properties of cytokines are often called adipocytokines. In recent years there has been increasing interest in a new adipokine called chemerin. Chemerin is a protein synthesized mostly by the adipose tissue and the liver as inactive pre-pro-chemerin. After the intracellular hydrolytic cutting off of the 20-amino-acid N-terminal polypeptide, it is secreted into the bloodstream as inactive pro-chemerin. Biologically active chemerin is then derived from pro-chemerin after cleavage of the C-terminal fragment by serum proteases involved in inflammation, coagulation and fibrinolysis. Proteolytic cleavage leads to formation of several chemerin-derived peptides, both biologically active (often with opposing functions and inactive.Within the last decade, there has been a growing number of publications regarding the role of chemerin in human disease. It seems to be implicated in the inflammatory response, metabolic syndrome, cardiovascular disease and alimentary tract disorders. The article presents the most recent information on the role of chemerin in human disease, and specifically alimentary tract disorders. The available evidence suggests that chemerin is an important link between adipose tissue mass, metabolic processes, the immune system and inflammation, and therefore plays a major role in human pathophysiology.

  3. Schistosoma hemozoin and its possible roles.

    Science.gov (United States)

    Xiao, Shu-Hua; Sun, Jun

    2017-03-01

    More than 95years ago Schistosoma pigment had been deemed as a degradation product of haemoglobin. Until the 1950s, scientists initiated to pay attention to understand the hematophagous habit of schistosomes, and to study the degradation of haemoglobin as well as the formation of hemozoin inside the gut of the worms. For a long time, the formation of hemozoin in both Plasmodium and in Schistosoma was considered to be the major route of heme detoxification, and hemozoin served a role in waste disposal. At the beginning of this century, the chemical structure of Schistosoma pigment was confirmed to be identical to that of malarial pigment (hemozoin) and its synthetic analogue, β-hematin. Since then, studies on Schistosoma hemozoin have been investigated by some workers and the results showed that Schistosoma hemozoin may play important roles in pathogenicity, immune modulation, iron supply for egg formation, and interaction with some anti-schistosomal drugs. In this review, we briefly review and discuss the hematophagous habit of schistosomes, degradation of haemoglobin, formation of hemozoin in the worm gut, and possible roles of hemozoin. Copyright © 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

  4. Dental expression and role in palliative treatment

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    Rajiv Saini

    2009-01-01

    Full Text Available World Health Organization defines palliative care as the active total care of patients whose disease is not responding to curative treatment. Palliative care for the terminally ill is based on a multidimensional approach to provide whole-person comfort care while maintaining optimal function; dental care plays an important role in this multidisciplinary approach. The aim of the present study is to review significance of dentist′s role to determine whether mouth care was effectively assessed and implemented in the palliative care setting. The oral problems experienced by the hospice head and neck patient clearly affect the quality of his or her remaining life. Dentist plays an essential role in palliative care by the maintenance of oral hygiene; dental examination may identify and cure opportunistic infections and dental disease like caries, periodontal disease, oral mucosal problems or prosthetic requirement. Oral care may reduce not only the microbial load of the mouth but the risk for pain and oral infection as well. This multidisciplinary approach to palliative care, including a dentist, may reduce the oral debilities that influence the patient′s ability to speak, eat or swallow. This review highlighted that without effective assessment of the mouth, the appropriate implementation of care will not be delivered. Palliative dental care has been fundamental in management of patients with active, progressive, far-advanced disease in which the oral cavity has been compromised either by the disease directly or by its treatment; the focus of care is quality of life.

  5. Explicit and implicit assessment of gender roles.

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    Fernández, Juan; Quiroga, M Ángeles; Escorial, Sergio; Privado, Jesús

    2014-05-01

    Gender roles have been assessed by explicit measures and, recently, by implicit measures. In the former case, the theoretical assumptions have been questioned by empirical results. To solve this contradiction, we carried out two concatenated studies based on a relatively well-founded theoretical and empirical approach. The first study was designed to obtain a sample of genderized activities of the domestic sphere by means of an explicit assessment. Forty-two raters (22 women and 20 men, balanced on age, sex, and level of education) took part as raters. In the second study, an implicit assessment of gender roles was carried out, focusing on the response time given to the sample activities obtained from the first study. A total of 164 adults (90 women and 74 men, mean age = 43), with experience in living with a partner and balanced on age, sex, and level of education, participated. Taken together, results show that explicit and implicit assessment converge. The current social reality shows that there is still no equity in some gender roles in the domestic sphere. These consistent results show considerable theoretical and empirical robustness, due to the double implicit and explicit assessment.

  6. The role of autophagy in cardiac hypertrophy

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    Li, Lanfang; Xu, Jin; He, Lu; Peng, Lijun; Zhong, Qiaoqing; Chen, Linxi; Jiang, Zhisheng

    2016-01-01

    Autophagy is conserved in nature from lower eukaryotes to mammals and is an important self-cannibalizing, degradative process that contributes to the elimination of superfluous materials. Cardiac hypertrophy is primarily characterized by excess protein synthesis, increased cardiomyocyte size, and thickened ventricular walls and is a major risk factor that promotes arrhythmia and heart failure. In recent years, cardiomyocyte autophagy has been considered to play a role in controlling the hypertrophic response. However, the beneficial or aggravating role of cardiomyocyte autophagy in cardiac hypertrophy remains controversial. The exact mechanism of cardiomyocyte autophagy in cardiac hypertrophy requires further study. In this review, we summarize the controversies associated with autophagy in cardiac hypertrophy and provide insights into the role of autophagy in the development of cardiac hypertrophy. We conclude that future studies should emphasize the relationship between autophagy and the different stages of cardiac hypertrophy, as well as the autophagic flux and selective autophagy. Autophagy will be a potential therapeutic target for cardiac hypertrophy. PMID:27084518

  7. Role of calcium in selenium cataract.

    Science.gov (United States)

    Shearer, T R; David, L L

    The purpose of this research was to test the role of certain minerals in the formation of cataract caused by an overdose of selenium. Several pieces of information indicated that lenticular calcium may play an important role in selenite cataractogenesis: 1) Lens calcium concentrations in selenite treated rats were increased more than 5-fold, and the increase in lens calcium was localized in the nucleus. 2) Lens calcium concentrations were elevated at least one full day before actual formation of nuclear cataract, but serum calcium levels were not changed. 3) In older rats not susceptible to selenite cataract, lens calcium was not significantly increased. 4) No evidence was found for a generalized disruption in lens permeability, since no major changes in lens water, sodium, and potassium levels were observed, and 5) when levels of calcium observed in selenite cataract were added to solutions of soluble proteins from rat lenses, light scattering was increased. Selenium-overdose cataracts may provide an important model for studies on the role of calcium in cataractogenesis.

  8. Role of Robot-Assisted Pelvic Surgery

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    Iqbal Singh

    2009-01-01

    Full Text Available The purpose of this study was to assess the current role of robot-assisted urological surgery in the female pelvis. The recently published English literature was reviewed to evaluate this role, with special emphasis on reconstructive procedures. These included colposuspension for genuine female stress urinary incontinence, repair of female genitourinary fistulas, ureterosciatic hernias, sacrocolpopexy for vault prolapse, ureterolysis and omental wrap for retroperitoneal fibrosis, ureteric reimplantation, and bladder surgery. To date, a wide spectrum of urogynecological reconstructive procedures have been performed with the assistance of the surgical robot and have been reported worldwide. Currently, a number of female pelvic ablative and reconstructive procedures are technically feasible with the aid of the surgical robot. While the role of robot-assisted surgery for bladder cancer, ureterolysis, ureteric reimplantation, repair of genitourinary fistulas, colposuspension, and sacrocolpopexy is nearly established among urologists, other procedures, such as myomectomy, simple hysterectomy, trachelectomy, and Wertheim's hysterectomy, are still evolving with gynecologists. The advantages of robot assistance include better hand-eye coordination, three-dimensional magnified stereoscopic vision with depth perception, intuitive movements with increased precision, and filtering of hand tremors. For most of the currently performed procedures in selected patients, the robot-assisted surgical outcomes appear to be relatively superior as compared to an open and purely laparoscopic surgical procedure.

  9. The role of autophagy in cardiac hypertrophy.

    Science.gov (United States)

    Li, Lanfang; Xu, Jin; He, Lu; Peng, Lijun; Zhong, Qiaoqing; Chen, Linxi; Jiang, Zhisheng

    2016-06-01

    Autophagy is conserved in nature from lower eukaryotes to mammals and is an important self-cannibalizing, degradative process that contributes to the elimination of superfluous materials. Cardiac hypertrophy is primarily characterized by excess protein synthesis, increased cardiomyocyte size, and thickened ventricular walls and is a major risk factor that promotes arrhythmia and heart failure. In recent years, cardiomyocyte autophagy has been considered to play a role in controlling the hypertrophic response. However, the beneficial or aggravating role of cardiomyocyte autophagy in cardiac hypertrophy remains controversial. The exact mechanism of cardiomyocyte autophagy in cardiac hypertrophy requires further study. In this review, we summarize the controversies associated with autophagy in cardiac hypertrophy and provide insights into the role of autophagy in the development of cardiac hypertrophy. We conclude that future studies should emphasize the relationship between autophagy and the different stages of cardiac hypertrophy, as well as the autophagic flux and selective autophagy. Autophagy will be a potential therapeutic target for cardiac hypertrophy. © The Author 2016. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. The role of cannabinoids in adult neurogenesis

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    Prenderville, Jack A; Kelly, Áine M; Downer, Eric J

    2015-01-01

    The processes underpinning post-developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both intrinsic (cell signalling cascades) and extrinsic (neurotrophins, neurotransmitters, cytokines, hormones) signalling molecules are intimately associated with adult neurogenesis and largely dictate the proliferative activity and differentiation capacity of neural cells. Cannabinoids are a unique class of chemical compounds incorporating plant-derived cannabinoids (the active components of Cannabis sativa), the endogenous cannabinoids and synthetic cannabinoid ligands, and these compounds are becoming increasingly recognized for their roles in neural developmental processes. Indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both CB1 and CB2 receptors. In recent years, a large body of literature has deciphered the signalling networks involved in cannabinoid-mediated regulation of neurogenesis. This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets. Overall, these findings identify the central role of the cannabinoid system in adult neurogenesis in the hippocampus and the lateral ventricles and hence provide insight into the processes underlying post-developmental neurogenesis in the mammalian brain. PMID:25951750

  11. Role of CFTR in epithelial physiology.

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    Saint-Criq, Vinciane; Gray, Michael A

    2017-01-01

    Salt and fluid absorption and secretion are two processes that are fundamental to epithelial function and whole body fluid homeostasis, and as such are tightly regulated in epithelial tissues. The CFTR anion channel plays a major role in regulating both secretion and absorption in a diverse range of epithelial tissues, including the airways, the GI and reproductive tracts, sweat and salivary glands. It is not surprising then that defects in CFTR function are linked to disease, including life-threatening secretory diarrhoeas, such as cholera, as well as the inherited disease, cystic fibrosis (CF), one of the most common life-limiting genetic diseases in Caucasian populations. More recently, CFTR dysfunction has also been implicated in the pathogenesis of acute pancreatitis, chronic obstructive pulmonary disease (COPD), and the hyper-responsiveness in asthma, underscoring its fundamental role in whole body health and disease. CFTR regulates many mechanisms in epithelial physiology, such as maintaining epithelial surface hydration and regulating luminal pH. Indeed, recent studies have identified luminal pH as an important arbiter of epithelial barrier function and innate defence, particularly in the airways and GI tract. In this chapter, we will illustrate the different operational roles of CFTR in epithelial function by describing its characteristics in three different tissues: the airways, the pancreas, and the sweat gland.

  12. Dynamic role of myofibroblasts in oral lesions

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    Bagul, Neeta; Ganjre, Anjali; Goryawala, SN; Kathariya, Rahul; Dusane, Shrikant

    2015-01-01

    Fibroblasts are the most abundant cellular components of connective tissue. They possess phenotypical heterogenicity and may be present in the form of smooth muscle cells or myofibroblasts (MFs). MFs are spindle-shaped cells with stress fibres and well-developed fibronexus, and they display α-smooth muscle actin immunohistochemically and smooth-muscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived from various sources, they play pivotal roles not only by synthesizing and producing extracellular matrix components, such as other connective tissue cells, but also are involved in force production. In the tissue remodelling phase of wound closure, integrin-mediated interactions between MFs and type I collagen result in scar tissue formation. The tumour stroma in oral cancer actively recruits various cell types into the tumour mass, where they act as different sources of MFs. This article reviews the importance of MFs and its role in pathological processes such as wound healing, odontogenic cysts and tumours, salivary gland tumours, oral preneoplasia, and oral squamous cell carcinoma. Research oriented on blocking the transdifferentiation of fibroblasts into MFs can facilitate the development of noninvasive therapeutic strategies for the treatment of fibrosis and/or cancer. PMID:26677439

  13. The role of Aire in clonal selection.

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    Taniguchi, Ruth T; Anderson, Mark S

    2011-01-01

    In his clonal selection theory, Frank Macfarlane Burnet predicted that autoreactive lymphocytes are deleted to prevent autoimmunity. This and other principles of lymphocyte behavior outlined by Burnet guided many studies that lead to our current understanding of thymic selection. Thus, when the genetic mutation responsible for autoimmune polyglandular syndrome type 1 was mapped to the autoimmune regulator (AIRE) gene, and Aire was found to be highly expressed in thymic epithelium, studying the role of Aire in negative selection made sense in the context of modern models of thymic selection. We now know Aire is a transcription factor required for the expression of many tissue-specific antigens (TSAs) in the thymus. In the absence of functional Aire, human patients and mice develop multi-organ autoimmune disease because of a defect in thymic negative selection. In addition to its role in the thymus, recent work in our lab suggests that extrathymic Aire-expressing cells have an important role in the clonal deletion of autoreactive CD8+ T cells. In this review, we summarize the latest studies on thymic and peripheral Aire-expressing cells, as well as other TSA-expressing stromal cell populations in peripheral lymphoid organs. We also discuss theoretical differences in thymic and peripheral Aire function that warrant further studies.

  14. Sex-Role Egalitarian Attitudes and Gender Role Socialization Experiences of African American Men and Women: A Mixed Methods Paradigm

    Science.gov (United States)

    Heard, Courtney Christian Charisse

    2013-01-01

    The purpose of this study was to assess the sex-role egalitarian attitudes and gender role socialization experiences of African American men and women. A sequential mixed-methods design was employed to research this phenomenon. The Sex-Role Egalitarianism Scale-Short Form BB (SRES-BB) was utilized to assess sex-role egalitarian attitudes (King…

  15. Defining the role of a PACS technologist.

    Science.gov (United States)

    Cabrera, Alfred

    2002-01-01

    As hospitals convert from conventional image processing to picture archiving and communication systems (PACS) technology, new job opportunities arose for PACS analysts, PACS system administrators, PACS operators, and PACS trainers. To support a PACS, these positions require education in computer information systems and work experience in information technology. At Texas Children's Hospital, new roles for radiologic technologists (RT) in supporting the operation of PACS were not recognized until after implementation of the filmless system. A new position entitled PACS technologis was created, but roles and responsibilities largely were undefined. The inadequate job description contributed to problems with appropriate utilization of the PACS technologist. The primary role of the technologist was nebulous, and the priority of tasks was undefined. There was an excessive volume of information and technology to be mastered. The role represented a new paradigm, so no template for the job description was available that encompassed the array of functions to be performed. The result was a "morph" of the RT and PACS analyst job descriptions that was contrived and unworkable. The role of the PACS technologist is vital to the operation of the radiology department that uses PACS. There is a well-established need for cross training of RTs in PACS. PACS technology is not taught in RT training programs. There are recurrent communications problems between RT and Information Technology (IT) personnel. The PACS technologist can participate in a number of activities that improve the overall level of proficiency in the imaging operation, such as specialized PACS training for RTs, collection and analysis of quality control data, and planning for installations of PACS acquisition modalities. RTs have acquired knowledge of medical terminology and human anatomy, imaging modalities, and workflow. These qualifications constitute a common basis for communication with other RTs, physicians, and

  16. Role of oxidative stress in female reproduction

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    Sharma Rakesh K

    2005-07-01

    Full Text Available Abstract In a healthy body, ROS (reactive oxygen species and antioxidants remain in balance. When the balance is disrupted towards an overabundance of ROS, oxidative stress (OS occurs. OS influences the entire reproductive lifespan of a woman and even thereafter (i.e. menopause. OS results from an imbalance between prooxidants (free radical species and the body's scavenging ability (antioxidants. ROS are a double-edged sword – they serve as key signal molecules in physiological processes but also have a role in pathological processes involving the female reproductive tract. ROS affect multiple physiological processes from oocyte maturation to fertilization, embryo development and pregnancy. It has been suggested that OS modulates the age-related decline in fertility. It plays a role during pregnancy and normal parturition and in initiation of preterm labor. Most ovarian cancers appear in the surface epithelium, and repetitive ovulation has been thought to be a causative factor. Ovulation-induced oxidative base damage and damage to DNA of the ovarian epithelium can be prevented by antioxidants. There is growing literature on the effects of OS in female reproduction with involvement in the pathophsiology of preeclampsia, hydatidiform mole, free radical-induced birth defects and other situations such as abortions. Numerous studies have shown that OS plays a role in the pathoysiology of infertility and assisted fertility. There is some evidence of its role in endometriosis, tubal and peritoneal factor infertility and unexplained infertility. This article reviews the role OS plays in normal cycling ovaries, follicular development and cyclical endometrial changes. It also discusses OS-related female infertility and how it influences the outcomes of assisted reproductive techniques. The review comprehensively explores the literature for evidence of the role of oxidative stress in conditions such as abortions, preeclampsia, hydatidiform mole, fetal

  17. A study of role expansion: a new GP role in cardiology care

    Science.gov (United States)

    2014-01-01

    Background The National Health Service is reconfiguring health care services in order to meet the increasing challenge of providing care for people with long-term conditions and to reduce the demand on specialised outpatient hospital services by enhancing primary care. A review of cardiology referrals to specialised care and the literature on referral management inspired the development of a new GP role in Cardiology. This new extended role was developed to enable GPs to diagnose and manage patients with mild to moderate heart failure or atrial fibrillation and to use a range of diagnostics effectively in primary care. This entailed GPs participating in a four-session short course with on-going clinical supervision. The new role was piloted in a small number of GP practices in one county in England for four months. This study explores the impact of piloting the Extended Cardiology role on the GP’s role, patients’ experience, service delivery and quality. Methods A mixed methods approach was employed including semi-structured interviews with GPs, a patient experience survey, a quality review of case notes, and analysis on activity and referral data. Results The participating GPs perceived the extended GP role as a professional development opportunity that had the potential to reduce healthcare utilisation and costs, through a reduction in referrals, whilst meeting the patient’s wishes for the provision of care closer to home. Patient experience of the new GP service was positive. The standard of clinical practice was judged acceptable. There was a fall in referrals during the study period. Conclusion This new role in cardiology was broadly welcomed as a model of care by the participating GPs and by patients, because of the potential to improve the quality of care for patients in primary care and reduce costs. As this was a pilot study further development and continuing evaluation of the model is recommended. PMID:24885826

  18. The role of water in animal breeding

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    Monica Serrantoni

    2006-07-01

    Full Text Available The role of water in animal breeding must be extended to a wider context than the animal production area, considering that 70% of the water used in the world is consumed by the whole production chain (agriculture and animal production. Therefore has a great importance the connection with other fields of the chain, as the fodder-growing and the cereal-growing, together with the evaluation and quantification of the environmental impacts. Water, that plays an essential role in the breeding, assumes different importance in relation to the animal class (birds, fish and mammals and to the animal species. Therefore are extremely different the water requirements and the water consumptions, that are moreover strongly influenced by many factors, such as the dry matter, the climatic breeding conditions, together with the individual animal features. All that represents the starting point to determine the strategies and the ways of the water giving in animal breeding, related to the technological, project and management aspects. Besides the quantitative aspects, water must be considered as food, because it is necessary to animal survival. The importance of the quality of water used in animal breeding and its nutritional role is closely related to the qualitative characteristics and to the presence of residual and polluting substances. The animal production chain, moreover, can produce environmental impacts on the aquatic ecosystems and therefore a particular attention goes to end uses of water as output of the whole animal production chain and to the quantification of the impacts, that is extremely complicate and difficult, depending on many variables. The considerations related to animal production chain assume a different value in the productive context of the management of the water resources in the third countries.

  19. The role of geoscientists in human progress

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    Stefania Lucchesi

    2012-07-01

    Full Text Available Like any science, geology has a key role in the development and progress of human culture and society. In this context, scientists, professionals and practitioners of Earth sciences must inevitably confront themselves with the purposes, methods and results of their studies, concerning relationships between man and his environment, which thus deals with ethical questions. An essential base for any geo-environmental action should be respect for the natural ecosystem. This can be achieved by encouraging an ‘affectionate attitude’ towards Nature or ecology. Some ancient cultures had a great awareness of the close relationships between humankind and the Earth. The recent web-based ‘Museo Torino’ (Turin Museum multimedia product shows the ‘history of a city’ (Turin, Italy in a dimension of unity and as a continuum of space–time–life between the history of the Earth and of humans. Geoscientists are not limited to merely having a pragmatic vision of the Earth, but should pursue harmonious collaboration between man and Nature. Within complex Earth systems, scientists and professionals rediscover their geoethical roles by responsibly evaluating and managing georesources, for progress aimed at improving conditions of life and human dignity. Geoscientists can also promote respect for ‘human rights’ through appropriate educational and training actions, for the balanced exploitation of our georesources. An example from Mendoza (Argentina is presented here, to encourage opportunities for meetings on environmental issues among people of different backgrounds and cultures. Last, but not least, there is the ethical role of geoscientists in ‘the service of the truth’. A misleading view of Earth systems by geoscientists can lead to fatalism or myths that often affect people from the psychological and sociological points of view.

  20. Matrix metalloproteinase 1: role in sarcoma biology.

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    Muhammad Umar Jawad

    2010-12-01

    Full Text Available In carcinomas stromal cells participate in cancer progression by producing proteases such as MMPs. The expression MMP1 is a prognostic factor in human chondrosarcoma, however the role in tumor progression is unknown. Laser capture microdissection and In Situ hybridization were used to determine cellular origin of MMP1 in human sarcomas. A xenogenic model of tumor progression was then used and mice were divided in two groups: each harboring either the control or a stably MMP1 silenced cell line. Animals were sacrificed; the neovascularization, primary tumor volumes, and metastatic burden were assessed. LCM and RNA-ISH analysis revealed MMP1 expression was predominantly localized to the tumor cells in all samples of sarcoma (p = 0.05. The percentage lung metastatic volume at 5 weeks (p = 0.08 and number of spontaneous deaths secondary to systemic tumor burden were lower in MMP1 silenced cell bearing mice. Interestingly, this group also demonstrated a larger primary tumor size (p<0.04 and increased angiogenesis (p<0.01. These findings were found to be consistent when experiment was repeated using a second independent MMP1 silencing sequence. Prior clinical trials employing MMP1 inhibitors failed because of a poor understanding of the role of MMPs in tumor progression. The current findings indicating tumor cell production of MMP1 by sarcoma cells is novel and highlights the fundamental differences in MMP biology between carcinomas and sarcomas. The results also emphasize the complex roles of MMP in tumor progression of sarcomas. Not only does metastasis seem to be affected by MMP1 silencing, but also local tumor growth and angiogenesis are affected inversely.