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Sample records for wisconsin abc layout

  1. Preconceptual ABC design definition and system configuration layout

    International Nuclear Information System (INIS)

    Barthold, W.

    1995-03-01

    This document is the conceptual design document for the follow-on to the Molten Salt Breeder Reactor, known as the ABC type reactor. It addresses blanket design options, containment options, off-gas systems, drainage systems, and components/layouts of the primary, secondary, and tertiary systems, and it contains a number of diagrams for the configuration of the major systems

  2. Accelerator-based conversion (ABC) of weapons plutonium: Plant layout study and related design issues

    Energy Technology Data Exchange (ETDEWEB)

    Cowell, B.S.; Fontana, M.H. [Oak Ridge National Lab., TN (United States); Krakowski, R.A.; Beard, C.A.; Buksa, J.J.; Davidson, J.W.; Sailor, W.C.; Williamson, M.A. [Los Alamos National Lab., NM (United States)

    1995-04-01

    In preparation for and in support of a detailed R and D Plan for the Accelerator-Based Conversion (ABC) of weapons plutonium, an ABC Plant Layout Study was conducted at the level of a pre-conceptual engineering design. The plant layout is based on an adaptation of the Molten-Salt Breeder Reactor (MSBR) detailed conceptual design that was completed in the early 1070s. Although the ABC Plant Layout Study included the Accelerator Equipment as an essential element, the engineering assessment focused primarily on the Target; Primary System (blanket and all systems containing plutonium-bearing fuel salt); the Heat-Removal System (secondary-coolant-salt and supercritical-steam systems); Chemical Processing; Operation and Maintenance; Containment and Safety; and Instrumentation and Control systems. Although constrained primarily to a reflection of an accelerator-driven (subcritical) variant of MSBR system, unique features and added flexibilities of the ABC suggest improved or alternative approaches to each of the above-listed subsystems; these, along with the key technical issues in need of resolution through a detailed R&D plan for ABC are described on the bases of the ``strawman`` or ``point-of-departure`` plant layout that resulted from this study.

  3. Congruence ABC implies ABC

    OpenAIRE

    Ellenberg, Jordan S.

    2000-01-01

    The ABC conjecture of Masser and Oesterle' states that if (a,b,c) are coprime integers with a + b + c = 0, then sup(|a|,|b|,|c|) 0. Oesterle' has observed that if the ABC conjecture holds for all (a,b,c) with 16 | abc, then the full ABC conjecture holds. We extend that result to show that, for every integer N, the "congruence ABC conjecture" that ABC holds for all (a,b,c) with N|abc implies the full ABC conjecture.

  4. Layout Construction

    DEFF Research Database (Denmark)

    Frandsen, Gudmund Skovbjerg; Palsberg, Jens; Schmidt, Erik Meineche

    We design a system for generating newspaper layout proposals. The input to the system consists of editorial information (text, pictures, etc) and style information (non-editorial information that specifies the aesthetic appearance of a layout). We consider the automation of layout construction...... to pose two main problems. One problem consists in optimizing the layout with respect to the constraints and preferences specified in the style information. Another problem consists in finding a representation of the style information that both supports its use in the combinatorial optimization...

  5. Course Layout

    OpenAIRE

    2005-01-01

    present roll Presentation roll Interactive Media Element This is an interactive diagram of a MATLAB course layout covering 16 topics in 4 different main areas: Basics of MATLAB, Numerical Methods in MATLAB, Symbolic Manipulations in MATLAB, Mathematical Modeling in MATLAB and Simulink AE2440 Introduction to Digital Computation

  6. Layout of the LER [Low Energy Ring] Arc

    International Nuclear Information System (INIS)

    Hutton, A.

    1990-01-01

    We have recently been trying to accumulate all of the information necessary to decide on the layout of the regular curved arcs of the Low Energy Ring (LER) and there have been several ABC Notes published on different aspects of the problem. This note will describe the layout that has been derived from these considerations

  7. Professionsbachelorens ABC

    DEFF Research Database (Denmark)

    Svendsen, Christian Bundgaard

    2008-01-01

    På baggrund af Lars-Henrik Schmidts "Sociale ABC" og Bloom og Dreyfus' taksonomier gives der et teoretiske bud på professionsbachelorbegrebet......På baggrund af Lars-Henrik Schmidts "Sociale ABC" og Bloom og Dreyfus' taksonomier gives der et teoretiske bud på professionsbachelorbegrebet...

  8. Symmetrization of Facade Layouts

    KAUST Repository

    Jiang, Haiyong

    2016-02-26

    We present an automatic approach for symmetrizing urban facade layouts. Our method can generate a symmetric layout through minimally modifying the original input layout. Based on the principles of symmetry in urban design, we formulate facade layout symmetrization as an optimization problem. Our method further enhances the regularity of the final layout by redistributing and aligning elements in the layout. We demonstrate that the proposed solution can effectively generate symmetric facade layouts.

  9. Facade Layout Symmetrization

    KAUST Repository

    Jiang, Haiyong

    2016-04-11

    We present an automatic algorithm for symmetrizing facade layouts. Our method symmetrizes a given facade layout while minimally modifying the original layout. Based on the principles of symmetry in urban design, we formulate the problem of facade layout symmetrization as an optimization problem. Our system further enhances the regularity of the final layout by redistributing and aligning boxes in the layout. We demonstrate that the proposed solution can generate symmetric facade layouts efficiently. © 2015 IEEE.

  10. Underground Layout Configuration

    International Nuclear Information System (INIS)

    A. Linden

    2003-01-01

    The purpose of this analysis was to develop an underground layout to support the license application (LA) design effort. In addition, the analysis will be used as the technical basis for the underground layout general arrangement drawings

  11. Civilsamfundets ABC

    DEFF Research Database (Denmark)

    Lund, Anker Brink; Meyer, Gitte

    Filantropiske fonde og foreninger får stadig større indflydelse på udviklingen af det danske samfund – fra kunst, kultur, byggeri og byudvikling til forskning og udvikling af den danske velfærdsstat. Gennem 32 essays giver Anker Brink Lund og Gitte Meyer en oplysende – og polemisk – analyse af de...... for almenvelllet? CIVILSAMFUNDETS ABC er skrevet på baggrund af et udredningsprojekt om civilsamfundets rolle i det danske samfund. Såvel udredningsprojektet som ABC’en er finansieret af Realdania...

  12. 75 FR 18828 - Wisconsin Electric Power Company, Wisconsin Gas LLC, Wisconsin Public Service Corporation...

    Science.gov (United States)

    2010-04-13

    ... Energy Regulatory Commission Wisconsin Electric Power Company, Wisconsin Gas LLC, Wisconsin Public Service Corporation: Complainants; ANR Pipeline Company: Respondent; Notice of Complaint April 6, 2010....206 (2009), Wisconsin Electric Power Company, Wisconsin Gas LLC, and Wisconsin Public Service...

  13. Layouts of Expander Graphs

    OpenAIRE

    Dujmović, Vida; Sidiropoulos, Anastasios; Wood, David R.

    2015-01-01

    Bourgain and Yehudayoff recently constructed $O(1)$-monotone bipartite expanders. By combining this result with a generalisation of the unraveling method of Kannan, we construct 3-monotone bipartite expanders, which is best possible. We then show that the same graphs admit 3-page book embeddings, 2-queue layouts, 4-track layouts, and have simple thickness 2. All these results are best possible.

  14. Reconfigurable layout problem

    NARCIS (Netherlands)

    Meng, G.; Heragu, S.S.; Heragu, S.S.; Zijm, Willem H.M.

    2004-01-01

    This paper addresses the reconfigurable layout problem, which differs from traditional, robust and dynamic layout problems mainly in two aspects: first, it assumes that production data are available only for the current and upcoming production period. Second, it considers queuing performance

  15. ABC Kinga kauplused = ABC King shoe stores

    Index Scriptorium Estoniae

    2011-01-01

    Tallinnas Kristiine keskuses, Tartu Kaubamajas ja Pärnus Port Artur 2 asuvate ABC Kinga kaupluste sisekujundusest. Sisearhitekid Andres Labi ja Janno Roos (Ruumilabor OÜ), loetletud nende ühiselt tehtud töid

  16. Design and Simulation Plant Layout Using Systematic Layout Planning

    Science.gov (United States)

    Suhardini, D.; Septiani, W.; Fauziah, S.

    2017-12-01

    This research aims to design the factory layout of PT. Gunaprima Budiwijaya in order to increase production capacity. The problem faced by this company is inappropriate layout causes cross traffic on the production floor. The re-layout procedure consist of these three steps: analysing the existing layout, designing plant layout based on SLP and evaluation and selection of alternative layout using Simulation Pro model version 6. Systematic layout planning is used to re-layout not based on the initial layout. This SLP produces four layout alternatives, and each alternative will be evaluated based on two criteria, namely cost of material handling using Material Handling Evaluation Sheet (MHES) and processing time by simulation. The results showed that production capacity is increasing as much as 37.5% with the addition of the machine and the operator, while material handling cost was reduced by improvement of the layout. The use of systematic layout planning method reduces material handling cost of 10,98% from initial layout or amounting to Rp1.229.813,34.

  17. Periodical Publishing in Wisconsin. Proceedings of the Conference on Periodical Publishing in Wisconsin (Madison, WI, May 11-12, 1978).

    Science.gov (United States)

    Danky, James P., Ed.; And Others

    The papers contained in this compilation were drawn from the proceedings of a 1978 conference on periodical publishing in Wisconsin. Papers in the first section of the collection deal with the basics of publishing and cover such topics as selecting articles, starting a new publication, mailing procedures, aesthetics and layout, and printing…

  18. Enhancing the ABC Cross

    OpenAIRE

    Euske, K.J.; Vercio, Alan

    2007-01-01

    The purpose of the ABC Cross was to portray both a cost and process view of an organization as simply as possible. Unfortunately, the model’s simplified form does not capture the real value of activity-based costing (ABC) for cost accounting that emerged in the mid-1980s. Here we present several ABC models that can help functional and process managers make better decisions.

  19. Site Recommendation Subsurface Layout

    International Nuclear Information System (INIS)

    C.L. Linden

    2000-01-01

    The purpose of this analysis is to develop a Subsurface Facility layout that is capable of accommodating the statutory capacity of 70,000 metric tons of uranium (MTU), as well as an option to expand the inventory capacity, if authorized, to 97,000 MTU. The layout configuration also requires a degree of flexibility to accommodate potential changes in site conditions or program requirements. The objective of this analysis is to provide a conceptual design of the Subsurface Facility sufficient to support the development of the Subsurface Facility System Description Document (CRWMS M andO 2000e) and the ''Emplacement Drift System Description Document'' (CRWMS M andO 2000i). As well, this analysis provides input to the Site Recommendation Consideration Report. The scope of this analysis includes: (1) Evaluation of the existing facilities and their integration into the Subsurface Facility design. (2) Identification and incorporation of factors influencing Subsurface Facility design, such as geological constraints, thermal loading, constructibility, subsurface ventilation, drainage control, radiological considerations, and the Test and Evaluation Facilities. (3) Development of a layout showing an available area in the primary area sufficient to support both the waste inventories and individual layouts showing the emplacement area required for 70,000 MTU and, if authorized, 97,000 MTU

  20. The ABC and AUSSAT.

    Science.gov (United States)

    McGarritty, Ian

    1985-01-01

    Discusses the Australian Broadcasting Corporation's (ABC) utilization of the AUSSAT telecommunications satellite to extend its television and radio transmission range to reach remote Australian audiences; the satellite's program gathering and interchange capabilities; and ABC's generation of other benefits to offset cost of satellite services.…

  1. Alpine Pixel Detector Layout

    CERN Document Server

    Delebecque, P; The ATLAS collaboration; Geffroy, N; Massol, N; Rambure, T; Todorov, T

    2013-01-01

    A description of an optimized layout of pixel sensors based on a stave that combines both barrel and endcap module orientations. The mechanical stiffness of the structure is provided by carbon fiber shells spaced by carbon foam. The cooling of the modules is provided by two-phase $CO_{2}$ flowing in a thin titanium pipe glued inside the carbon fiber foam. The electrical services of all modules are provided by a single stave flex. This layout eliminates the need for separate barrel and endcap detector structures, and therefore the barrel services material in front of the endcap. The transition from barrel to endcap module orientation is optimized separately for each layer in order to minimize the active pixel area and the traversed material. The sparse module spacing in the endcap part of the stave allows for multiple fixation points, and for a stiff overall structure composed only of staves interconnected by stiff disks.

  2. Electrostatic Levitator Layout

    Science.gov (United States)

    1998-01-01

    Electrostatic Levitator (ESL) general layout with captions. The ESL uses static electricity to suspend an object (about 2-3 mm in diameter) inside a vacuum chamber while a laser heats the sample until it melts. This lets scientists record a wide range of physical properties without the sample contacting the container or any instruments, conditions that would alter the readings. The Electrostatic Levitator is one of several tools used in NASA's microgravity materials science program.

  3. Structure completion for facade layouts

    KAUST Repository

    Fan, Lubin

    2014-11-18

    (Figure Presented) We present a method to complete missing structures in facade layouts. Starting from an abstraction of the partially observed layout as a set of shapes, we can propose one or multiple possible completed layouts. Structure completion with large missing parts is an ill-posed problem. Therefore, we combine two sources of information to derive our solution: the observed shapes and a database of complete layouts. The problem is also very difficult, because shape positions and attributes have to be estimated jointly. Our proposed solution is to break the problem into two components: a statistical model to evaluate layouts and a planning algorithm to generate candidate layouts. This ensures that the completed result is consistent with the observation and the layouts in the database.

  4. Rapportering med ABC modellen

    DEFF Research Database (Denmark)

    Wiese, Lars Ole

    2006-01-01

    I denne artikel diskuteres Activity Based Costing (ABC) som rapporterings-teknik for kunde profitabilitet. Der argumenteres for, at indtægtserhvervel-sen inkl. dens direkte omkostningsforbrug bør adskilles fra omkostnings-beskrivelsen til produktfremstilling. Dvs. der gennemføres en aktivitetsba......-seret rapportering for indtægter og en ABC model for omkostningsforbrug til produktfremstilling. Modellen er tilført logiske beslutningsobjekter (klas-sifikationer), som er opbygget niveaubaseret. Samtidigt føres belæg for, at ABC modellen bør baseres på logiske fordelinger til kalkulationsobjektet i stedet...

  5. Thermodynamics of ABC transporters

    Directory of Open Access Journals (Sweden)

    Xuejun C. Zhang

    2015-09-01

    Full Text Available ABSTRACT ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.

  6. Iowa ABC connections.

    Science.gov (United States)

    2015-06-01

    For several years the Iowa Department of Transportation (DOT), Iowa State University, the Federal Highway Administration, : and several Iowa counties have been working to develop accelerated bridge construction (ABC) concepts, details, and processes....

  7. Auditory Spatial Layout

    Science.gov (United States)

    Wightman, Frederic L.; Jenison, Rick

    1995-01-01

    All auditory sensory information is packaged in a pair of acoustical pressure waveforms, one at each ear. While there is obvious structure in these waveforms, that structure (temporal and spectral patterns) bears no simple relationship to the structure of the environmental objects that produced them. The properties of auditory objects and their layout in space must be derived completely from higher level processing of the peripheral input. This chapter begins with a discussion of the peculiarities of acoustical stimuli and how they are received by the human auditory system. A distinction is made between the ambient sound field and the effective stimulus to differentiate the perceptual distinctions among various simple classes of sound sources (ambient field) from the known perceptual consequences of the linear transformations of the sound wave from source to receiver (effective stimulus). Next, the definition of an auditory object is dealt with, specifically the question of how the various components of a sound stream become segregated into distinct auditory objects. The remainder of the chapter focuses on issues related to the spatial layout of auditory objects, both stationary and moving.

  8. Layout and composition for animation

    CERN Document Server

    Ghertner, Ed

    2012-01-01

    This essential, hands-on guide is filled with examples of what a composition should look like and example of poorly designed layouts. Spot potential problems before they cost time and money, and adapt creative solutions for your own projects with this invaluable resource for beginner and intermediate artists.  With Beauty and the Beast examples and Simpson character layouts, readers will learn how to develop character layout and background layout as well as strengthen composition  styles with a creative toolset of trick shot examples and inspirational case studies. A companion website will

  9. The EPR layout design

    International Nuclear Information System (INIS)

    Mast, U.; Le Carrer, P.Y.

    2001-01-01

    General: The European Pressurised Water Reactor (EPR) is a French - German development for the next generation of Pressurised Water Reactor. The new reactor design is based on the experiences of operation and design of nuclear power plants in both countries. The EPR fulfils enhanced safety standards, higher availability and a longer service life. Utilities aspects: For the Utilities one important requirement is the reduction of personnel exposure during maintenance and in-service inspection. The other significant requirement is of economic nature. The main points influencing costs, which have also impact on the layout, are: outage times, accessibility of the reactor building and the available maintenance and set down areas. The Utilities have also required to load the spent fuel assemblies into the shipping cask from the bottom of the fuel pool, because of the exclusion of the drop of the cask and in order to avoid contamination at the outer cask shell. Layout and safety aspects: All safety relevant Nuclear Island (NI) buildings are designed against design earthquake as well as explosion pressure wave. The protection against Airplane Crash (APC) is realised by civil and layout dispositions. The Reactor Building, the Safeguard Buildings division 2 and 3 and the Fuel Building are protected by concrete structures. The other safety relevant nuclear buildings are protected by geographical separation. Important safety requirements are the further reduction of the probability of severe accidents and the mitigation of such an accident on the plant area. For that, a spreading area for molten corium, a channel from the reactor pit to the spreading area and the In Containment Refuelling Water Storage Tank (IRWST) for flooding and initial cooling of the corium, were implemented in the design of the Reactor Building. Layout results: The following buildings are arranged on a common raft to protect them against design earthquake: Reactor Building (RB), Safeguard Buildings (SAB

  10. Underground layout tradeoff study

    International Nuclear Information System (INIS)

    1988-01-01

    This report presents the results of a technical and economic comparative study of four alternative underground layouts for a nuclear waste geologic repository in salt. The four alternatives considered in this study are (1) separate areas for spent fuel (SF) and commercial high-level waste (CHLW); (2) panel alternation, in which SF and CHLW are emplaced in adjacent panels of rooms; (3) room alternation, in which SF and CHLW are emplaced in adjacent rooms within each panel; and (4) intimate mixture, in which SF and CHLW are emplaced in random order within each storage room. The study concludes that (1) cost is not an important factor; (2) the separate-areas and intimate-mixture alternatives appear, technically, to be more desirable than the other alternatives; and (3) the selection between the separate-areas and intimate mixture alternatives depends upon future resolution of site-specific and reprocessing questions. 5 refs., 6 figs., 12 tabs

  11. Forests of Wisconsin, 2013

    Science.gov (United States)

    Charles H. Perry

    2014-01-01

    This resource update provides an overview of forest resources in Wisconsin based on an inventory conducted by the U.S. Forest Service, Forest Inventory and Analysis (FIA) program at the Northern Research Station in cooperation with the Wisconsin Department of Natural Resources. Data estimates are based on field data collected using the FIA annualized sample design and...

  12. Strength layout of pipelines

    International Nuclear Information System (INIS)

    Moczall, K.; Schmid, H.J.

    1976-01-01

    Different properties are required from pipes of nuclear power plants according to their respective importance for the safety as well as the availability of a plant. For reasons of expediency and profitability, it has therefore been necessary to attach 5 requiremental stages to the above-mentioned as well as to all other components. Of the five stages, the first three represent those which are of major, medium or minor importance for safety of nuclear plants. The 4th stage gives in general the importance of the availability of a plant, whereas the 5th stage is provided for the rest of the pipes. The requirements of conventional, technical regulations are generally fulfilled in the 4th stage, whereas, phased accordingly, exceeding requirements are set up and specified in the first three stages. These requirements refer to the securing of the workability of plant components, to (redundant, resp. diverse) layout, and to the quality of components (qualifying of producers and production processes, preliminary checking of production papers, supervision of production, material and construction testing, documentation) as well as to strength verification (pressure test, stress-strain measurements, stress and fatigue analysis). (orig.) [de

  13. Investigation on repository layouts

    Energy Technology Data Exchange (ETDEWEB)

    Tanai, Kenji [Tokai, Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan); Iwasa, Kengo; Hasegawa, Hiroshi [Head Office, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan); Gouke, Mitsuo; Horita, Masakuni [Shimizu Corp., Tokyo (Japan); Noda, Masaru [Ohbayashi Corp., Tokyo (Japan)

    1999-11-01

    This report consists of three items : (1) Study of the repository configuration, (2) Study of the surface facilities configuration for construction, operation and backfilling, (3) Planning schedule. In the repository configuration, the basic factors influencing the design of the repository configuration are presented, and the results of studies of various possible repository configurations are presented for both hard and soft rock systems. Here, the minimum conditions regarding geological environment required to guide design are assumed, because it is difficult to determine the repository configuration without considering specific conditions of a disposal site. In the surface facility configuration, it is illustrated based on the results of construction, operation, backfilling studies for underground disposal facility and EIS report of CANADA. In the schedule, the overall schedule corresponding to the repository layout is outlined in link with the milestone of disposal schedule set forth in the government's basic policy. The assumptions and the basic conditions are summarized to examine the General Schedule from start of construction to closure of a repository. This summary is based on the technologies to be used for construction, operation and closure of a repository. The basic national policies form the framework for this review of the general schedule. (author)

  14. Die Deutschen in Wisconsin (Germans in Wisconsin).

    Science.gov (United States)

    Wisconsin State Dept. of Public Instruction, Madison.

    The following curriculum units comprise this course book: (1) Germans in a New Home, (2) Contributions of the Germans in Wisconsin, (3) A Letter to Germany, (4) Germans Come to Kingston, (5) First a Soldier, Then a Man of the Church (about Heinrich von Rohr), (6) A Visiting German, and (7) Germans and Music. Each unit begins with a reading of…

  15. Practical Aspects of CMOS Layout

    DEFF Research Database (Denmark)

    Stassen, Flemming

    1996-01-01

    The topics covered in these notes are the practical aspects and limitations of layout, when random process variations result in electrical parameters, which are not constant but rather statistically distributed.The focus is on design methods for reducing or eliminating the effects. The notes cover...... three aspects:1) to introduce layout structures robust to process variations2) to present simplistic models for analog building blocks with the aim of analysing consequences of parameter variations3) to present the basic noise considerations which guide the layout of supply structures etc....

  16. Computing layouts with deformable templates

    KAUST Repository

    Peng, Chi-Han

    2014-07-22

    In this paper, we tackle the problem of tiling a domain with a set of deformable templates. A valid solution to this problem completely covers the domain with templates such that the templates do not overlap. We generalize existing specialized solutions and formulate a general layout problem by modeling important constraints and admissible template deformations. Our main idea is to break the layout algorithm into two steps: a discrete step to lay out the approximate template positions and a continuous step to refine the template shapes. Our approach is suitable for a large class of applications, including floorplans, urban layouts, and arts and design. Copyright © ACM.

  17. Plant ABC Transporters

    Science.gov (United States)

    Kang, Joohyun; Park, Jiyoung; Choi, Hyunju; Burla, Bo; Kretzschmar, Tobias; Lee, Youngsook; Martinoia, Enrico

    2011-01-01

    ABC transporters constitute one of the largest protein families found in all living organisms. ABC transporters are driven by ATP hydrolysis and can act as exporters as well as importers. The plant genome encodes for more than 100 ABC transporters, largely exceeding that of other organisms. In Arabidopsis, only 22 out of 130 have been functionally analyzed. They are localized in most membranes of a plant cell such as the plasma membrane, the tonoplast, chloroplasts, mitochondria and peroxisomes and fulfill a multitude of functions. Originally identified as transporters involved in detoxification processes, they have later been shown to be required for organ growth, plant nutrition, plant development, response to abiotic stresses, pathogen resistance and the interaction of the plant with its environment. To fulfill these roles they exhibit different substrate specifies by e.g. depositing surface lipids, accumulating phytate in seeds, and transporting the phytohormones auxin and abscisic acid. The aim of this review is to give an insight into the functions of plant ABC transporters and to show their importance for plant development and survival. PMID:22303277

  18. ABC's of Being Smart

    Science.gov (United States)

    Foster, Joanne

    2011-01-01

    Determining what giftedness is all about means focusing on many aspects of the individual. In this paper, the author focuses on letter D of the ABC's of being smart. She starts with specifics about giftedness (details), and then moves on to some ways of thinking (dispositions).

  19. Design & layout of recreation facilities

    Science.gov (United States)

    Howard R. Orr

    1971-01-01

    Design and layout of recreation facilities is a problem solving process that must be divorced from the emotionalism that has shrouded outdoor recreation and must deal deliberately with the growing information concerning people and natural resources.

  20. [Research progress in chondroitinase ABC].

    Science.gov (United States)

    Li, Ye; Chen, Zhenya; Yuan, Qipeng

    2015-05-01

    As the components of proteoglycans, glycosaminoglycans (GAGs) are linear polysaccharides consisting of hexose and uronic acid units linked by β-1,3-glycosidic bond. GAGs mainly distribute in extracellular matrix and on cell surfaces. They guide many biological processes, such as proliferation of cells, transmission of signals and mediation of inflammation. Because of their large molecular weights, GAGs have limited biological functions in vitro. However, the appearance of chondroitinase ABC (ChSase ABC), which can lyse polysaccharides, solves the difficulties. Based on our work, we summarized the classification and the crystal structure of ChSase ABC, as well as other recent research progress on ChSase ABCs. The separation and purification methods of ChSase ABC and construction of engineering bacteria are illustrated. The stability and immobilization are also analyzed by taking account of the characterization of ChSase ABC. Finally, problems and future prospect of the ChSase ABC study are summarized.

  1. Optimization-Based Layout Design

    OpenAIRE

    Abdel-Malek, K.; Mi, Z.; Yang, J.; Nebel, K.

    2005-01-01

    The layout problem is of importance to ergonomists, vehicle/cockpit packaging engineers, designers of manufacturing assembly lines, designers concerned with the placement of levers, knobs, controls, etc. in the reachable workspace of a human, and also to users of digital human modeling code, where digital prototyping has become a valuable tool. This paper proposes a hybrid optimization method (gradient-based optimization and simulated annealing) to obtain the layout design. We implemented the...

  2. Barns of Wisconsin

    Science.gov (United States)

    Watson-Newlin, Karen

    2008-01-01

    In this article, the author shares a painting unit she introduced to her students. In this unit, her students painted pictures of barns and discussed the historical significance of barns in Wisconsin.

  3. COMPUTER AIDED SELECTION OF PLANT LAYOUT

    African Journals Online (AJOL)

    This paper deals with the fundamental concepts of plant layout, in which the need for plant layout, the systematic and logical approaches to the problems, layout solutions and the objectives of plant layout are discussed. Further the approaches and the scoring techniques of the two available computer rout ines are ...

  4. ABC+SCM=Sant?

    OpenAIRE

    Dahl, Jonas; Porelius, Jesper

    2006-01-01

    Background: Companies of today commonly search to gain competitive advantages throughout different forms of co-operation, one of which is referred to as Supply Chain Management. Although little research has been assigned to the topic of how to manage and control this type of relation, lately a growing number of academics has been arguing that ABC is an appropriate mean of controlling this type of relationships. Purpose: The purpose of this thesis is to investigate to what degree the ongoing d...

  5. Accelerating ROP detector layout optimization

    International Nuclear Information System (INIS)

    Kastanya, D.; Fodor, B.

    2012-01-01

    The ADORE (Alternating Detector layout Optimization for REgional overpower protection system) algorithm for performing the optimization of regional overpower protection (ROP) system for CANDU® reactors have been recently developed. The simulated annealing (SA) stochastic optimization technique is utilized to come up with a quasi optimized detector layout for the ROP systems. Within each simulated annealing history, the objective function is calculated as a function of the trip set point (TSP) corresponding to the detector layout for that particular history. The evaluation of the TSP is done probabilistically using the ROVER-F code. Since during each optimization execution thousands of candidate detector layouts are evaluated, the overall optimization process is time consuming. Since for each ROVER-F evaluation the number of fuelling ripples controls the execution time, reducing the number of fuelling ripples used during the calculation of TSP will reduce the overall optimization execution time. This approach has been investigated and the results are presented in this paper. The challenge is to construct a set of representative fuelling ripples which will significantly speedup the optimization process while guaranteeing that the resulting detector layout has similar quality to the ones produced when the complete set of fuelling ripples is employed. Results presented in this paper indicate that a speedup of up to around 40 times is attainable when this approach is utilized. (author)

  6. Design of the storage location based on the ABC analyses

    Science.gov (United States)

    Jemelka, Milan; Chramcov, Bronislav; Kříž, Pavel

    2016-06-01

    The paper focuses on process efficiency and saving storage costs. Maintaining inventory through putaway strategy takes personnel time and costs money. The aim is to control inventory in the best way. The ABC classification based on Villefredo Pareto theory is used for a design of warehouse layout. New design of storage location reduces the distance of fork-lifters, total costs and it increases inventory process efficiency. The suggested solutions and evaluation of achieved results are described in detail. Proposed solutions were realized in real warehouse operation.

  7. Structural diversity of ABC transporters

    Science.gov (United States)

    ter Beek, Josy; Guskov, Albert

    2014-01-01

    ATP-binding cassette (ABC) transporters form a large superfamily of ATP-dependent protein complexes that mediate transport of a vast array of substrates across membranes. The 14 currently available structures of ABC transporters have greatly advanced insight into the transport mechanism and revealed a tremendous structural diversity. Whereas the domains that hydrolyze ATP are structurally related in all ABC transporters, the membrane-embedded domains, where the substrates are translocated, adopt four different unrelated folds. Here, we review the structural characteristics of ABC transporters and discuss the implications of this structural diversity for mechanistic diversity. PMID:24638992

  8. Optimization-Based Layout Design

    Directory of Open Access Journals (Sweden)

    K. Abdel-Malek

    2005-01-01

    Full Text Available The layout problem is of importance to ergonomists, vehicle/cockpit packaging engineers, designers of manufacturing assembly lines, designers concerned with the placement of levers, knobs, controls, etc. in the reachable workspace of a human, and also to users of digital human modeling code, where digital prototyping has become a valuable tool. This paper proposes a hybrid optimization method (gradient-based optimization and simulated annealing to obtain the layout design. We implemented the proposed algorithm for a project at Oral-B Laboratories, where a manufacturing cell involves an operator who handles three objects, some with the left hand, others with the right hand.

  9. Curva ABC de fornecedores

    OpenAIRE

    Solano, Renato da Silva

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. Este trabalho faz uma revisão e busca dar uma contribuição aos gerentes de Planejamento, Programação, Controle e Gerenciamento de Empreendimentos e Obras através do uso das Curvas ABC. O trabalho utilizou 10 empreendimentos de classificação Alta (NBR 12721), incorporados por oito empresas do setor e fez uma análise dos projetos-padrão da NBR 12721. Foi f...

  10. Cache-Oblivious Mesh Layouts

    International Nuclear Information System (INIS)

    Yoon, S; Lindstrom, P; Pascucci, V; Manocha, D

    2005-01-01

    We present a novel method for computing cache-oblivious layouts of large meshes that improve the performance of interactive visualization and geometric processing algorithms. Given that the mesh is accessed in a reasonably coherent manner, we assume no particular data access patterns or cache parameters of the memory hierarchy involved in the computation. Furthermore, our formulation extends directly to computing layouts of multi-resolution and bounding volume hierarchies of large meshes. We develop a simple and practical cache-oblivious metric for estimating cache misses. Computing a coherent mesh layout is reduced to a combinatorial optimization problem. We designed and implemented an out-of-core multilevel minimization algorithm and tested its performance on unstructured meshes composed of tens to hundreds of millions of triangles. Our layouts can significantly reduce the number of cache misses. We have observed 2-20 times speedups in view-dependent rendering, collision detection, and isocontour extraction without any modification of the algorithms or runtime applications

  11. Do You Know Your ABC?

    Science.gov (United States)

    Neale, Claire

    2013-01-01

    Within primary schools, the core subjects of literacy and numeracy are highly regarded, and rightly so, as children need to learn to read, write and be numerically literate. This means that all children learn their ABCs at an early age, But, what about the "other ABC"--"Airway, Breathing and Circulation?" Accidents and medical…

  12. ABC Technology Development Program

    International Nuclear Information System (INIS)

    1994-01-01

    The Accelerator-Based Conversion (ABC) facility will be designed to accomplish the following mission: 'Provide a weapon's grade plutonium disposition capability in a safe, economical, and environmentally sound manner on a prudent schedule for [50] tons of weapon's grade plutonium to be disposed on in [20] years.' This mission is supported by four major objectives: provide a reliable plutonium disposition capability within the next [15] years; provide a level of safety and of safety assurance that meets or exceeds that afforded to the public by modern commercial nuclear power plants; meet or exceed all applicable federal, state, and local regulations or standards for environmental compliance; manage the program in a cost effective manner. The ABC Technology Development Program defines the technology development activities that are required to accomplish this mission. The technology development tasks are related to the following topics: blanket system; vessel systems; reactivity control systems; heat transport system components; energy conversion systems; shutdown heat transport systems components; auxiliary systems; technology demonstrations - large scale experiments

  13. Learning from Wisconsin

    Science.gov (United States)

    Daniel, Jamie Owen

    2011-01-01

    Like thousands of other people from around the country and around the world, this author was heartened and inspired by the tenacity, immediacy, and creativity of the pushback by Wisconsin's public-sector unions against Governor Scott Walker's efforts to limit their collective bargaining rights. And like many others who made the trek to Madison to…

  14. Wisconsin's forest resources, 2010

    Science.gov (United States)

    C.H. Perry

    2011-01-01

    This publication provides an overview of forest resource attributes for Wisconsin based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) program at the Northern Research Station of the U.S. Forest Service. These estimates, along with web-posted core tables, will be updated annually. For more information please refer to page 4 of this report...

  15. Wisconsin's forest resources, 2005

    Science.gov (United States)

    Charles, H. (Hobie) Perry; Gary J. Brand

    2006-01-01

    The annual forest inventory of Wisconsin continues, and this document reports 2001-05 moving averages for most variables and comparisons between 2000 and 2005 for growth, removals, and mortality. Summary resource tables can be generated through the Forest Inventory Mapmaker website at http://ncrs2.fs.fed.us/4801/fiadb/index. htm. Estimates from this inventory show a...

  16. Wisconsin's forest resources, 2006

    Science.gov (United States)

    C.H. Perry; V.A. Everson

    2007-01-01

    Figure 2 was revised by the author in August 2008. This publication provides an overview of forest resource attributes for Wisconsin based on an annual inventory conducted by the Forest Inventory and Analysis program at the Northern Research Station of the U.S. Forest Service from 2002-2006. These estimates, along with associated core tables postedon the Internet, are...

  17. Wisconsin's Forest Resources, 2007

    Science.gov (United States)

    C.H. Perry; V.A. Everson

    2008-01-01

    This publication provides an overview of forest resource attributes for Wisconsin based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) program of the U.S. Forest Service, Northern Research Station. These estimates, along with web-posted core tables, are updated annually. For more information please refer to page 4 of this report.

  18. Wisconsin's forest resources, 2009

    Science.gov (United States)

    C.H. Perry

    2011-01-01

    This publication provides an overview of forest resource attributes for Wisconsin based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) program at the Northern Research Station of the U.S. Forest Service. These estimates, along with web-posted core tables, will be updated annually. For more information, please refer to page 4 of this report...

  19. HOLA: Human-like Orthogonal Network Layout.

    Science.gov (United States)

    Kieffer, Steve; Dwyer, Tim; Marriott, Kim; Wybrow, Michael

    2016-01-01

    Over the last 50 years a wide variety of automatic network layout algorithms have been developed. Some are fast heuristic techniques suitable for networks with hundreds of thousands of nodes while others are multi-stage frameworks for higher-quality layout of smaller networks. However, despite decades of research currently no algorithm produces layout of comparable quality to that of a human. We give a new "human-centred" methodology for automatic network layout algorithm design that is intended to overcome this deficiency. User studies are first used to identify the aesthetic criteria algorithms should encode, then an algorithm is developed that is informed by these criteria and finally, a follow-up study evaluates the algorithm output. We have used this new methodology to develop an automatic orthogonal network layout method, HOLA, that achieves measurably better (by user study) layout than the best available orthogonal layout algorithm and which produces layouts of comparable quality to those produced by hand.

  20. The chemistry of ABC

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, R.J. [Los Alamos National Laboratory, NM (United States)

    1995-10-01

    ABC stand for accelerator based conversion of Pu. It is a unique approach to Pu destruction that allows for a well controlled and complete burn of Pu as may be required by treaty or policy. The central idea of the approach is to provide a spallation source of neutrons that allows the operation of a fissioning system without a critical mass and at a K effective less than one. Material to be fissioned is suspended in a molten salt medium for high temperature control and on-line removal of neutron absorbing fission products. This paper discusses the issues associated with the selection and operation of a molten salt chemical system: redox control, product removal, material feed, solubilities, deposition control, and a host of operational procedures.

  1. Computational Design of Urban Layouts

    KAUST Repository

    Wonka, Peter

    2015-10-07

    A fundamental challenge in computational design is to compute layouts by arranging a set of shapes. In this talk I will present recent urban modeling projects with applications in computer graphics, urban planning, and architecture. The talk will look at different scales of urban modeling (streets, floorplans, parcels). A common challenge in all these modeling problems are functional and aesthetic constraints that should be respected. The talk also highlights interesting links to geometry processing problems, such as field design and quad meshing.

  2. Wisconsin's Forests 2009

    Science.gov (United States)

    Charles H. Perry; Vern A. Everson; Brett J. Butler; Susan J. Crocker; Sally E. Dahir; Andrea L. Diss-Torrance; Grant M Domke; Dale D. Gormanson; Sarah K. Herrick; Steven S. Hubbard; Terry R. Mace; Patrick D. Miles; Mark D. Nelson; Richard B. Rodeout; Luke T. Saunders; Kirk M. Stueve; Barry T. Wilson; Christopher W. Woodall

    2012-01-01

    The second full annual inventory of Wisconsin's forests reports more than 16.7 million acres of forest land with an average volume of more than 1,400 cubic feet per acre. Forest land is dominated by the oak/hickory forest-type group, which occupies slightly more than one quarter of the total forest land area; the maple/beech/birch forest-type group occupies an...

  3. The ABCs of Sex Ed.

    Science.gov (United States)

    Sroka, Stephen R.

    2002-01-01

    Cites statistics on extent of sexually transmitted diseases and pregnancies among adolescents; describes ideological dispute over how to teach sex education; advocates teaching the ABCs of sex education: Abstinence, Be Monogamous, and Condoms. (PKP)

  4. Politseiniku lustlik ABC / Pekka Erelt

    Index Scriptorium Estoniae

    Erelt, Pekka, 1965-

    1999-01-01

    Politsei on välja andnud 'Politseiniku ABC', mis antakse igale politseinikule. Karikaturist Heiki Ernits on peaaegu igale taskuraamatu leheküljele joonistanud pildikese mundrimeestest kentsakates situatsioonides.

  5. ITER fuel cycle systems layout

    International Nuclear Information System (INIS)

    Kveton, O.K.

    1990-10-01

    The ITER fuel cycle building (FCB) will contain the following systems: fuel purification - permeator based; fuel purification - molecular sieves; impurity treatment; waste water storage and treatment; isotope separation; waste water tritium extraction; tritium extraction from solid breeder; tritium extraction from test modules; tritium storage, shipping and receiving; tritium laboratory; atmosphere detritiation systems; fuel cycle control centre; tritiated equipment maintenance space; control maintenance space; health physics laboratory; access, access control and facilities. The layout of the FCB and the requirements for these systems are described. (10 figs.)

  6. ABC transporters in adaptive immunity.

    Science.gov (United States)

    Seyffer, Fabian; Tampé, Robert

    2015-03-01

    ABC transporters ubiquitously found in all kingdoms of life move a broad range of solutes across membranes. Crystal structures of four distinct types of ABC transport systems have been solved, shedding light on different conformational states within the transport process. Briefly, ATP-dependent flipping between inward- and outward-facing conformations allows directional transport of various solutes. The heterodimeric transporter associated with antigen processing TAP1/2 (ABCB2/3) is a crucial element of the adaptive immune system. The ABC transport complex shuttles proteasomal degradation products into the endoplasmic reticulum. These antigenic peptides are loaded onto major histocompatibility complex class I molecules and presented on the cell surface. We detail the functional modules of TAP, its ATPase and transport cycle, and its interaction with and modulation by other cellular components. In particular, we emphasize how viral factors inhibit TAP activity and thereby prevent detection of the infected host cell by cytotoxic T-cells. Merging functional details on TAP with structural insights from related ABC transporters refines the understanding of solute transport. Although human ABC transporters are extremely diverse, they still may employ conceptually related transport mechanisms. Appropriately, we delineate a working model of the transport cycle and how viral factors arrest TAP in distinct conformations. Deciphering the transport cycle of human ABC proteins is the major issue in the field. The defined peptidic substrate, various inhibitory viral factors, and its role in adaptive immunity provide unique tools for the investigation of TAP, making it an ideal model system for ABC transporters in general. This article is part of a Special Issue entitled Structural biochemistry and biophysics of membrane proteins. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. ABCdb: an ABC transporter database.

    Science.gov (United States)

    Quentin, Y; Fichant, G

    2000-10-01

    We present the first release of a database devoted to the ATP-binding cassette (ABC) protein domains (ABCdb). The ABC proteins are involved in a wide variety of physiological processes in Archea, Bacteria and Eucaryota where they are encoded by large families of paralogous genes. The majority of ABC domains energize the transport of compounds across the membranes. In bacteria, ABC transporters are involved in the uptake of a wide range of molecules and in mechanisms of virulence and antibiotic resistance. In eukaryotes, most of them are involved in drug resistance and in human cells, many are associated with diseases. Sequence analysis reveals that members of the ABC superfamily can be organized into sub-families and suggests that they have diverged from common ancestral forms. In this release, ABCdb includes the inventory and assembly of the ABC transporter systems of completely sequenced genomes. In addition to the protein entries, the database comprises information on functional domains, sequence motifs, predicted trans-membrane segments, and signal peptides. It also includes a classification in sub-families of the ABC systems as well as a classification of the different partners of the systems. Evolutionary trees and specific sequence patterns are provided for each sub-family. The database is endowed with a powerful query system and it was interfaced with blastP2 program for similarity searches. ABCdb has been developed in the ACeDB format, a database system developed by Jean Thierry-Mieg and Richard Durbin. ABCdb can be accessed via the World Wide Web (http://ir2lcb.cnrs-mrs.fr/ABCdb/).

  8. Generating and exploring good building layouts

    KAUST Repository

    Bao, Fan

    2013-07-16

    Good building layouts are required to conform to regulatory guidelines, while meeting certain quality measures. While different methods can sample the space of such good layouts, there exists little support for a user to understand and systematically explore the samples. Starting from a discrete set of good layouts, we analytically characterize the local shape space of good layouts around each initial layout, compactly encode these spaces, and link them to support transitions across the different local spaces. We represent such transitions in the form of a portal graph. The user can then use the portal graph, along with the family of local shape spaces, to globally and locally explore the space of good building layouts. We use our framework on a variety of different test scenarios to showcase an intuitive design, navigation, and exploration interface. Copyright © ACM. Copyright © ACM 2013.

  9. Patch layout generation by detecting feature networks

    KAUST Repository

    Cao, Yuanhao

    2015-02-01

    The patch layout of 3D surfaces reveals the high-level geometric and topological structures. In this paper, we study the patch layout computation by detecting and enclosing feature loops on surfaces. We present a hybrid framework which combines several key ingredients, including feature detection, feature filtering, feature curve extension, patch subdivision and boundary smoothing. Our framework is able to compute patch layouts through concave features as previous approaches, but also able to generate nice layouts through smoothing regions. We demonstrate the effectiveness of our framework by comparing with the state-of-the-art methods.

  10. Iowa ABC connections : [tech transfer summary].

    Science.gov (United States)

    2015-06-01

    The Iowa Department of Transportation (DOT) and other organizations have : been developing accelerated bridge construction (ABC) concepts, details, and : processes, and Iowa has come to be viewed as a national leader in the area of : ABC. However, th...

  11. Interactive Graph Layout of a Million Nodes

    Directory of Open Access Journals (Sweden)

    Peng Mi

    2016-12-01

    Full Text Available Sensemaking of large graphs, specifically those with millions of nodes, is a crucial task in many fields. Automatic graph layout algorithms, augmented with real-time human-in-the-loop interaction, can potentially support sensemaking of large graphs. However, designing interactive algorithms to achieve this is challenging. In this paper, we tackle the scalability problem of interactive layout of large graphs, and contribute a new GPU-based force-directed layout algorithm that exploits graph topology. This algorithm can interactively layout graphs with millions of nodes, and support real-time interaction to explore alternative graph layouts. Users can directly manipulate the layout of vertices in a force-directed fashion. The complexity of traditional repulsive force computation is reduced by approximating calculations based on the hierarchical structure of multi-level clustered graphs. We evaluate the algorithm performance, and demonstrate human-in-the-loop layout in two sensemaking case studies. Moreover, we summarize lessons learned for designing interactive large graph layout algorithms on the GPU.

  12. Vegetation response to wagon wheel camp layouts.

    African Journals Online (AJOL)

    Wagon wheel camp layouts have been favoured, in some quarters, for rotational grazing due to the economy and convenience of having the camps radially arranged around central facilities. A possible disadvantage of such layouts is the tendency for over-grazing near the hub and under-grazing at the extremities.

  13. Staking Terraces Online: A Terrace Layout Program

    Science.gov (United States)

    Terrace construction in Missouri exceeded 3 million feet at a cost of over $8 million in 2008. Up to 50 % of the total construction and design time is spent on the terrace layout itself. A web-based computer program, MOTERR, has been developed to design terrace layouts. The program utilizes digital ...

  14. A Cadence layout wrapper for MATLAB

    OpenAIRE

    Tsirepli, Ismini

    2006-01-01

    In this thesis, the focus is on creating a wrapper between MATLAB and the Cadence Virtuoso design environment. The central idea is to use the wrapper and write the code for an entire analog layout as scripts in MATLAB. Basically, we will implement a set of necessary commands for performing the most fundamental tasks in layout generation from within MATLAB.

  15. Tornadoes Strike Northern Wisconsin

    Science.gov (United States)

    2007-01-01

    A series of tornadoes ripped through the Upper Midwest region of the United States in the evening of June 7, 2007. At least five different tornadoes touched down in Wisconsin, according to the Associated Press, one of which tore through the Bear Paw Resort in northern Wisconsin. Despite dropping as much as fifteen centimeters (six inches) of rain in some places and baseball-size hail in others, authorities were reporting no deaths attributable to the storm system, and only a smattering of injuries, but considerable property damage in some areas. When the MODIS instrument on NASA's Terra satellite observed the area on June 9, 2007, the track torn through the woods by one of the tornadoes stands out quite clearly. This photo-like image uses data collected by MODIS in the normal human vision range to give a familiar natural-looking appearance. The landscape is largely a checkerboard of farms, towns, roads, and cities. The pale land is predominantly farmland where crops have not fully grown in yet. Dark blue shows the winding path of rivers and lakes dotting the landscape. The large blue lake on the east (right) side of the image is Lake Michigan. Towns and cities, including the city of Green Bay, are gray. To the north side, farmland gives way to dark green as land use shifts from agriculture to the Menominee Indian Reservation and Nicolet National Forest. The diagonal slash through the dark green forested land shows the tornado track. Bare land was revealed where the tornado tore down trees or stripped vegetation off the branches. The high-resolution image provided above is at MODIS' full spatial resolution (level of detail) of 250 meters per pixel. The MODIS Rapid Response System provides this image at additional resolutions.

  16. The ABCs of particle physics

    CERN Document Server

    Biron, Lauren

    2016-01-01

    For lovers of rhymes and anthropomorphic Higgs bosons, Symmetry presents its first published board book, The ABCs of Particle Physics. Use it as an illustrated guide to basic particle- and astrophysics terms, or read it to your infant at bedtime, if you don’t mind their first word being “quark.”

  17. The peroxisomal ABC transporter family

    NARCIS (Netherlands)

    Wanders, Ronald J. A.; Visser, Wouter F.; van Roermund, Carlo W. T.; Kemp, Stephan; Waterham, Hans R.

    2007-01-01

    This review describes the current state of knowledge about the ABCD family of peroxisomal half adenosine-triphosphate-binding cassette (ABC) transporters. ABCDs are predicted to be present in a variety of eukaryotic organisms, although at present, only ABCDs in the yeast Saccharomyces cerevisiae,

  18. Luminaire layout: Design and implementation

    Science.gov (United States)

    Both, A. J.

    1994-01-01

    The information contained in this report was presented during the discussion regarding guidelines for PAR uniformity in greenhouses. The data shows a lighting uniformity analysis in a research greenhouse for rose production at the Cornell University campus. The luminaire layout was designed using the computer program Lumen-Micro. After implementation of the design, accurate measurements were taken in the greenhouse and the uniformity analysis for both the design and implementation were compared. A study of several supplemental lighting installations resulted in the following recommendations: include only the actual growing area in the lighting uniformity analysis; for growing areas up to 20 square meters, take four measurements per square meter; for growing areas above 20 square meters, take one measurement per square meter; use one of the uniformity criteria and frequency graphs to compare lighting uniformity amongst designs; and design for uniformity criterion of a least 0.75 and the fraction within +/- 15% of the average PAR value should be close to one.

  19. Wisconsin SRF Electron Gun Commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Bisognano, Joseph J. [University of Wisconsin-Madison; Bissen, M. [University of Wisconsin-Madison; Bosch, R. [University of Wisconsin-Madison; Efremov, M. [University of Wisconsin-Madison; Eisert, D. [University of Wisconsin-Madison; Fisher, M. [University of Wisconsin-Madison; Green, M. [University of Wisconsin-Madison; Jacobs, K. [University of Wisconsin-Madison; Keil, R. [University of Wisconsin-Madison; Kleman, K. [University of Wisconsin-Madison; Rogers, G. [University of Wisconsin-Madison; Severson, M. [University of Wisconsin-Madison; Yavuz, D. D. [University of Wisconsin-Madison; Legg, Robert A. [JLAB; Bachimanchi, Ramakrishna [JLAB; Hovater, J. Curtis [JLAB; Plawski, Tomasz [JLAB; Powers, Thomas J. [JLAB

    2013-12-01

    The University of Wisconsin has completed fabrication and commissioning of a low frequency (199.6 MHz) superconducting electron gun based on a quarter wave resonator (QWR) cavity. Its concept was optimized to be the source for a CW free electron laser facility. The gun design includes active tuning and a high temperature superconducting solenoid. We will report on the status of the Wisconsin SRF electron gun program, including commissioning experience and first beam measurements.

  20. Wisconsin's forest resources in 2004

    Science.gov (United States)

    Charles H. Perry

    2006-01-01

    Results of the 2000-2004 annual inventory of Wisconsin show about 16.0 million acres of forest land, more than 22.1 billion cubic feet of live volume on forest land, and nearly 593 million dry tons of all live aboveground tree biomass on timberland. Populations of jack pine budworm are increasing, and it remains a significant pest in Wisconsin forests. A complete...

  1. Layout Optimisation of Wave Energy Converter Arrays

    DEFF Research Database (Denmark)

    Ruiz, Pau Mercadé; Nava, Vincenzo; Topper, Mathew B. R.

    2017-01-01

    This paper proposes an optimisation strategy for the layout design of wave energy converter (WEC) arrays. Optimal layouts are sought so as to maximise the absorbed power given a minimum q-factor, the minimum distance between WECs, and an area of deployment. To guarantee an efficient optimisation......, a four-parameter layout description is proposed. Three different optimisation algorithms are further compared in terms of performance and computational cost. These are the covariance matrix adaptation evolution strategy (CMA), a genetic algorithm (GA) and the glowworm swarm optimisation (GSO) algorithm...

  2. [Preliminary analysis of ginseng industry in Wisconsin].

    Science.gov (United States)

    Hu, Li; Zhang, Wen-sheng

    2008-07-01

    To study the case of Wisconsin as the top ginseng state in United States which has come through four developing steps: beginning, stagnating, flourishing and now, downturn. The current situation of the ginseng industry in Wisconsin was briefly introduced, the federal and state management on ginseng cultivation and export, the organization of Ginseng Board of Wisconsin and their marketing style based on the field investigation and data collected from USDA and Wisconsin state. The advantages and disadvantages of Wisconsin ginseng industry were analyzed in order to provide some suggestions for Chinese medicine industry. Chinese ginseng industry should learn the organization system from Wisconsin.

  3. Wireless technology for ABC Assessment

    DEFF Research Database (Denmark)

    Kristensen, Margit; Kyng, Morten; Christensen, Erika Frischknecht

    be just beside a victim to assess the ABC status. Consequently - in situations with many victims - monitoring equipment is only used for the (few) most seriously injured. Our ongoing research builds on data collected through extensive field studies and is described in several published papers. We......  In medical emergency service (EMS) the ABC status (Airway-Breathing-Circulation) of victims is essential in the decision making process regarding prioritizing and treatment. Today's use of information technology does, however, not inform directly about "A" and "B". The parameters are evaluated...... indirectly through assessment of collected biosensor data, such as ECG, and directly by the rescuer regarding how the patient looks and sounds. Moreover, the monitoring equipment used today is connected with displays by wires and thus only utilizes one display at a time. This means that the rescuers must...

  4. Layout optimization using the homogenization method

    Science.gov (United States)

    Suzuki, Katsuyuki; Kikuchi, Noboru

    1993-01-01

    A generalized layout problem involving sizing, shape, and topology optimization is solved by using the homogenization method for three-dimensional linearly elastic shell structures in order to seek a possibility of establishment of an integrated design system of automotive car bodies, as an extension of the previous work by Bendsoe and Kikuchi. A formulation of a three-dimensional homogenized shell, a solution algorithm, and several examples of computing the optimum layout are presented in this first part of the two articles.

  5. INVENTORY CLASSIFICATION WITH ABC ANALYSIS

    OpenAIRE

    Kıyak, Erkan; Timuş, Oğuz Han; Karayel, Mehmet

    2015-01-01

    For a substantial organization, managing the expansive inventory is a serious problem. One of the methods to solve this problem used widely is classifying the inventory according to some criteria and managing inventory according to this classisifation. In this study, ABC classification methods are researched and Ng's model, which is one of the most widely used, selected for further investigation. An illustrative example is presented to show the usability of the Ng's method.

  6. ABC transporters in the CNS - an inventory.

    Science.gov (United States)

    Hartz, A M S; Bauer, B

    2011-04-01

    In the present review we provide a summary of ATP-binding cassette (ABC) transporters in the central nervous system (CNS). Our review is focused on transporters of the ABC A, B, C, D, and G families that have been detected in the cells of the neurovascular unit/blood-brain barrier including brain capillary endothelial cells, pericytes, astrocytes, and neurons, as well as in other brain cells, such as microglia, oligodendrocytes, and choroid plexus epithelial cells. In this review, we provide an overview, organized by ABC family, of transporter expression, localization, and function. We summarize recent findings on ABC transporter regulation in the CNS and address the role of ABC transporters in CNS diseases including brain cancer, seizures/epilepsy, and Alzheimer's disease. Finally, we discuss new therapeutic strategies focused on ABC transporters in CNS disease.

  7. An inventory of the human ABC proteins.

    Science.gov (United States)

    Klein, I; Sarkadi, B; Váradi, A

    1999-12-06

    Currently 30 human ABC proteins are represented by full sequences in various databases, and this paper provides a brief overview of these proteins. ABC proteins are composed of transmembrane domains (TMDs), and nucleotide binding domains (NBDs, or ATP-binding cassettes, ABSs). The arrangement of these domains, together with available membrane topology models of the family members, are presented. Based on their sequence similarity scores, the members of the human ABC protein family can be grouped into eight subfamilies. At present the MDR/TAP, the ALD, the MRP/CFTR, the ABC1, the White, the RNAseL inhibitor, the ANSA, and the GCN20 subfamilies are identified. Mutations of many human ABC proteins are known to be causative in inherited diseases, and a short description of the molecular pathology of these ABC gene-related genetic diseases is also provided.

  8. Enterprise Architecture Data Pada Hotel ABC

    OpenAIRE

    Soesatyo, Stephanie; Wibowo, Adi; Handojo, Andreas

    2015-01-01

    Hotel ABC is a company engaged in hospitality management, i.e. room rental, rental of meeting rooms and coffee shop. Hotel ABC has a branch that has the same specifications of the hotel. In business process, Hotel ABC has information systems to support existing business processes. However, existing information systems have not been integrated as a whole. Based on the condition stated above, analysis and design of enterprise architecture information system is created for the company. The proce...

  9. Computer aided selection of plant layout | Kitaw | Zede Journal

    African Journals Online (AJOL)

    This paper deals with the fundamental concepts of plant layout, in which the need for plant layout, the systematic and logical approaches to the problems, layout solutions and the objectives of plant layout are discussed. Further the approaches and the scoring techniques of the two available computer rout ines are ...

  10. 48 CFR 52.236-17 - Layout of Work.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Layout of Work. 52.236-17... Layout of Work. As prescribed in 36.517, insert the following clause in solicitations and contracts when... need for accurate work layout and for siting verification during work performance: Layout of Work (APR...

  11. Bioinformatic survey of ABC transporters in dermatophytes.

    Science.gov (United States)

    Gadzalski, Marek; Ciesielska, Anita; Stączek, Paweł

    2016-01-15

    ATP binding cassette (ABC) transporters constitute a very large and ubiquitous superfamily of membrane proteins. They are responsible for ATP hydrolysis driven translocation of countless substrates. Being a very old and diverse group of proteins present in all organisms they share a common feature, which is the presence of an evolutionary conservative nucleotide binding domain (NBD)--the engine that drives the transport. Another common domain is a transmembrane domain (TMD) which consists of several membrane-spanning helices. This part of protein is substrate-specific, thus it is much more variable. ABC transporters are known for driving drug efflux in many pathogens and cancer cells, therefore they are the subject of extensive studies. There are many examples of conferring a drug resistance phenotype in fungal pathogens by ABC transporters, however, little is known about these proteins in dermatophytes--a group of fungi causing superficial mycoses. So far only a single ABC transporter has been extensively studied in this group of pathogens. We analyzed available genomic sequences of seven dermatophyte species in order to provide an insight into dermatophyte ABC protein inventory. Phylogenetic studies of ABC transporter genes and their products were conducted and included ABC transporters of other fungi. Our results show that each dermatophyte genome studied possesses a great variety of ABC transporter genes. Detailed analysis of selected genes and their products indicates that relatively recent duplication of ABC transporter genes could lead to novel substrate specificity. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. An optimization tool for satellite equipment layout

    Science.gov (United States)

    Qin, Zheng; Liang, Yan-gang; Zhou, Jian-ping

    2018-01-01

    Selection of the satellite equipment layout with performance constraints is a complex task which can be viewed as a constrained multi-objective optimization and a multiple criteria decision making problem. The layout design of a satellite cabin involves the process of locating the required equipment in a limited space, thereby satisfying various behavioral constraints of the interior and exterior environments. The layout optimization of satellite cabin in this paper includes the C.G. offset, the moments of inertia and the space debris impact risk of the system, of which the impact risk index is developed to quantify the risk to a satellite cabin of coming into contact with space debris. In this paper an optimization tool for the integration of CAD software as well as the optimization algorithms is presented, which is developed to automatically find solutions for a three-dimensional layout of equipment in satellite. The effectiveness of the tool is also demonstrated by applying to the layout optimization of a satellite platform.

  13. Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe

    DEFF Research Database (Denmark)

    Christensen, P U; Davis, K; Nielsen, O

    1997-01-01

    We have isolated the abc1 gene from the fission yeast Schizosaccharomyces pombe. Sequence analysis suggests that the Abc1 protein is a member of the ABC superfamily of transporters and is composed of two structurally homologous halves, each consisting of a hydrophobic region of six transmembrane...... domains and a hydrophilic region containing one ATP-binding site. The abc1 gene appears to be expressed under all growth conditions but gene disruption experiments indicate that it is not essential for growth. The sequence of the abc1 gene has been deposited in the EMBL data library under the Accession...

  14. Layout Optimisation of Wave Energy Converter Arrays

    Directory of Open Access Journals (Sweden)

    Pau Mercadé Ruiz

    2017-08-01

    Full Text Available This paper proposes an optimisation strategy for the layout design of wave energy converter (WEC arrays. Optimal layouts are sought so as to maximise the absorbed power given a minimum q-factor, the minimum distance between WECs, and an area of deployment. To guarantee an efficient optimisation, a four-parameter layout description is proposed. Three different optimisation algorithms are further compared in terms of performance and computational cost. These are the covariance matrix adaptation evolution strategy (CMA, a genetic algorithm (GA and the glowworm swarm optimisation (GSO algorithm. The results show slightly higher performances for the latter two algorithms; however, the first turns out to be significantly less computationally demanding.

  15. Discrete optimization in architecture architectural & urban layout

    CERN Document Server

    Zawidzki, Machi

    2016-01-01

    This book presents three projects that demonstrate the fundamental problems of architectural design and urban composition – the layout design, evaluation and optimization. Part I describes the functional layout design of a residential building, and an evaluation of the quality of a town square (plaza). The algorithm for the functional layout design is based on backtracking using a constraint satisfaction approach combined with coarse grid discretization. The algorithm for the town square evaluation is based on geometrical properties derived directly from its plan. Part II introduces a crowd-simulation application for the analysis of escape routes on floor plans, and optimization of a floor plan for smooth crowd flow. The algorithms presented employ agent-based modeling and cellular automata.

  16. Residential Energy Efficiency Potential: Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-11-27

    Energy used by Wisconsin single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.

  17. Wisconsin's fourth forest inventory, 1983.

    Science.gov (United States)

    John S. Jr. Spencer; W. Brad Smith; Jerold T. Hahn; Gerhard K. Raile

    1988-01-01

    The fourth inventory of the timber resource of Wisconsin shows that growing-stock volume increased from 11.2 to 15.5 billion cubic feet between 1968 and 1983, and area of timberland increased from 14.5 to 14.8 million acres. Presented are analysis and statistics on forest area and timber volume, growth, mortality, removals, and projections.

  18. Wisconsin's forest resources in 2001.

    Science.gov (United States)

    John S. Vissage; Gery J. Brand; Manfred E. Mielke

    2003-01-01

    Results of the 2001 annual inventory of Wisconsin show about 15.8 million acres of forest land, more than 21.6 billion cubic feet of live volume on forest land, and nearly 584 million dry tons of all live aboveground tree biomass on timberland. Gypsy moth, forest tent caterpillar, twolined chestnut borer, bronze birch borer, ash yellows, and white pine blister rust...

  19. Educational Attainment in Southeast Wisconsin

    Science.gov (United States)

    Million, Laura; Henken, Rob; Dickman, Anneliese

    2010-01-01

    In metro Milwaukee, as a part of the WIRED Initiative, the Regional Workforce Alliance (RWA)--a collaboration of organizations representing workforce development, economic development and education across southeast Wisconsin--has established the framework for pursuing the local talent dividend goal and a regional strategy for increasing…

  20. Birds of Prey of Wisconsin.

    Science.gov (United States)

    Hamerstrom, Frances

    This copiously illustrated document is designed to be a field quide to birds of prey that are common to Wisconsin, as well as to some that enter the state occasionally. An introduction discusses birds of prey with regard to migration patterns, the relationship between common names and the attitudes of people toward certain birds, and natural signs…

  1. Playware ABC: Engineering Play for Everybody

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2017-01-01

    This paper describes the Playware ABC concept, and how it allows anybody, anywhere, anytime to be building bodies and brains, which facilitates users to construct, combine and create. The Playware ABC concept focuses engineering and IT system development on creating solutions that are usable by a...

  2. The ABC transporters in Candidatus Liberibacter asiaticus

    Science.gov (United States)

    Li, Wenlin; Cong, Qian; Pei, Jimin; Kinch, Lisa N; Grishin, Nick V

    2012-01-01

    Candidatus Liberibacter asiaticus (Ca. L. asiaticus) is a Gram-negative bacterium and the pathogen of Citrus Greening disease (Huanglongbing, HLB). As a parasitic bacterium, Ca. L. asiaticus harbors ABC transporters that play important roles in exchanging chemical compounds between Ca. L. asiaticus and its host. Here, we analyzed all the ABC transporter-related proteins in Ca. L. asiaticus. We identified 14 ABC transporter systems and predicted their structures and substrate specificities. In-depth sequence and structure analysis including multiple sequence alignment, phylogenetic tree reconstruction, and structure comparison further support their function predictions. Our study shows that this bacterium could use these ABC transporters to import metabolites (amino acids and phosphates) and enzyme cofactors (choline, thiamine, iron, manganese, and zinc), resist to organic solvent, heavy metal, and lipid-like drugs, maintain the composition of the outer membrane (OM), and secrete virulence factors. Although the features of most ABC systems could be deduced from the abundant experimental data on their orthologs, we reported several novel observations within ABC system proteins. Moreover, we identified seven nontransport ABC systems that are likely involved in virulence gene expression regulation, transposon excision regulation, and DNA repair. Our analysis reveals several candidates for further studies to understand and control the disease, including the type I virulence factor secretion system and its substrate that are likely related to Ca. L. asiaticus pathogenicity and the ABC transporter systems responsible for bacterial OM biosynthesis that are good drug targets. PMID:22807026

  3. ABC classification : service levels and inventory costs

    NARCIS (Netherlands)

    Teunter, R.H.; Babai, M.; Syntetos, A.

    2010-01-01

    ABC inventory classifications are widely used in practice, with demand value and demand volume as the most common ranking criteria. The standard approach in ABC applications is to set the same service level for all stock keeping units (SKUs) in a class. In this paper, we show (for three large real

  4. CMOS circuit design, layout and simulation

    CERN Document Server

    Baker, R Jacob

    2010-01-01

    The Third Edition of CMOS Circuit Design, Layout, and Simulation continues to cover the practical design of both analog and digital integrated circuits, offering a vital, contemporary view of a wide range of analog/digital circuit blocks including: phase-locked-loops, delta-sigma sensing circuits, voltage/current references, op-amps, the design of data converters, and much more. Regardless of one's integrated circuit (IC) design skill level, this book allows readers to experience both the theory behind, and the hands-on implementation of, complementary metal oxide semiconductor (CMOS) IC design via detailed derivations, discussions, and hundreds of design, layout, and simulation examples.

  5. Final Report: ATLAS Phase-2 Tracker Upgrade Layout Task Force

    CERN Document Server

    Clark, A; The ATLAS collaboration; Hessey, N; Mättig, P; Styles, N; Wells, P; Burdin, S; Cornelissen, T; Todorov, T; Vankov, P; Watson, I; Wenig, S

    2012-01-01

    he mandate of the Upgrade Layout Task Force was to develop a benchmark layout proposal for the ATLAS Phase-2 Upgrade Letter of Intent (LOI), due in late 2012. The work described in this note has evolved from simulation and design studies made using an earlier "UTOPIA" upgrade tracker layout, and experience gained from the current ATLAS Inner Detector during the first years of data taking. The layout described in this document, called the LoI-layout, will be used as a benchmark layout for the LoI and will be used for simulation and engineering studies described in the LoI.

  6. Concept Layout Model of Transportation Terminals

    Directory of Open Access Journals (Sweden)

    Li-ya Yao

    2012-01-01

    Full Text Available Transportation terminal is the key node in transport systems. Efficient terminals can improve operation of passenger transportation networks, adjust the layout of public transportation networks, provide a passenger guidance system, and regulate the development of commercial forms, as well as optimize the assembly and distribution of modern logistic modes, among others. This study aims to clarify the relationship between the function and the structure of transportation terminals and establish the function layout design. The mapping mechanism of demand, function, and structure was analyzed, and a quantitative relationship between function and structure was obtained from a design perspective. Passenger demand and terminal structure were decomposed into several demand units and structural elements following the principle of reverse engineering. The relationship maps between these two kinds of elements were then analyzed. Function-oriented concept layout model of transportation terminals was established using the previous method. Thus, a technique in planning and design of transportation structures was proposed. Meaningful results were obtained from the optimization of transportation terminal facilities, which guide the design of the functional layout of transportation terminals and improve the development of urban passenger transportation systems.

  7. Design and analysis of reconfigurable layout systems

    NARCIS (Netherlands)

    Heragu, Sunderesh; Zijm, Willem H.M.; Meng, Gang; Heragu, S.S.; van Ommeren, Jan C.W.; van Houtum, Geert-Jan

    2001-01-01

    In this paper, we present a framework for determining the layout in a manufacturing environment characterized by constantly changing product volumes and mix. Much of the production equipment is assumed to be relatively light weight and therefore their location can be easily changed to suit the

  8. Optimal Wafer Cutting in Shuttle Layout Problems

    DEFF Research Database (Denmark)

    Nisted, Lasse; Pisinger, David; Altman, Avri

    2011-01-01

    . The shuttle layout problem is frequently solved in two phases: first, a floorplan of the shuttle is generated. Then, a cutting plan is found which minimizes the overall number of wafers needed to satisfy the demand of each die type. Since some die types require special production technologies, only compatible...

  9. Terrace Layout Using a Computer Assisted System

    Science.gov (United States)

    Development of a web-based terrace design tool based on the MOTERR program is presented, along with representative layouts for conventional and parallel terrace systems. Using digital elevation maps and geographic information systems (GIS), this tool utilizes personal computers to rapidly construct ...

  10. Beam Dynamics and Layout arXiv

    CERN Document Server

    Lombardi, Alessandra

    In this paper, we give some guidelines for the design of linear accelerators, with special emphasis on their use in a hadron therapy facility. We concentrate on two accelerator layouts, based on linacs. The conventional one based on a linac injecting into a synchrotron and a all-linac solution based on high gradient high frequency RF cavities.

  11. Layout and Routing Methods for Warehouses

    NARCIS (Netherlands)

    K.J. Roodbergen (Kees-Jan)

    2001-01-01

    textabstractLayout and Routing Methods for Warehouses discusses aspects of order picking in warehouses. Order picking is the process by which products are retrieved from storage to meet customer demand. Various new routing methods are introduced to determine efficient sequences in which products

  12. Customisation of Indico pages - Layout and Menus

    CERN Multimedia

    CERN. Geneva; Ferreira, Pedro

    2017-01-01

    In this tutorial you are going to learn how to customize the layout of your Indico pages (for example you can change the color of the background images or change the logo) and the menus on your Indico pages  (for example you can add or hide certain blocks, or change their name and order).  

  13. Water resources of Wisconsin: lower Wisconsin River basin

    Science.gov (United States)

    Hindall, S.M.; Borman, Ronald G.

    1974-01-01

    This report describes the physical environment, availability, distribution, movement, quality, and use of water in the upper Wisconsin River basin as an aid in planning and water management. The report presents general information on the basin derived from data obtained from Federal, State, and local agencies, New field data were collected in areas where information was lacking. More detailed studies of problem areas may be required in the future, as water needs and related development increase.

  14. ABC transporters in megakaryopoiesis and platelet activity.

    Science.gov (United States)

    Wang, Wei; Buitrago, Lorena; Wang, Ying

    2017-08-01

    ATP-binding cassette (ABC) is a family of transporters that facilitates the translocation of substrates across cell membrane using its ATPase subunit. These transporters have key roles in multidrug resistance, lipid homeostasis, antigen processing, immunity, cell proliferation and hematopoiesis. Some ABC transporters are selectively expressed on megakaryocyte progenitor, megakaryocyte and its cellular fragment platelet. However, the role of ABC transporters in hemostasis and thrombosis were not well explored until recently. Studies of both human genetic diseases and genetically-manipulated animal models have greatly improved our understanding of ABC transporters in regulating hematopoiesis particularly megakaryopoiesis and/or platelet activity. Human genome wide association studies (GWAS) have also unraveled the association between ABC transporters and thrombopoiesis in general population. Therefore, this review aims to summarize the recent advances in our understanding of how ABC transporters regulate megakaryopoiesis and platelet activity, the underlining mechanisms and their association with atherosclerosis and atherothrombosis. Last, the emerging therapeutic targets to slow down atherosclerosis development and prevent atherothrombosis via ABC transporters or downstream pathways will also be discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Phylogenetic analysis of fungal ABC transporters

    Directory of Open Access Journals (Sweden)

    Driessen Arnold JM

    2010-03-01

    Full Text Available Abstract Background The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied. Results We performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe. Conclusions Data obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.

  16. An ABC for decision making

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, Luiz Henrique Costa, E-mail: luiz_mogi@yahoo.com.br [Associacao de Medicina Intensiva Brasileira (AMIB), Sao Paulo, SP (Brazil); Irmandade da Santa Casa de Misericordia de Sao Paulo, SP (Brazil); Ferreira, Bruna Cortez [Hospital de Base de Sao Jose do Rio Preto, SP (Brazil)

    2015-03-15

    The present study was aimed at proposing a systematic evaluation of cranial computed tomography, identifying the main aspects to be analyzed in order to facilitate the decision making process regarding diagnosis and management in emergency settings. The present descriptive study comprised a literature review at the following databases: Access Medicine and Access Emergency Medicine (McGraw-Hill Education); British Medical Journal Evidence Center; UptoDate; Bireme; PubMed; Lilacs; SciELO; ProQuest; Micromedex (Thomson Reuters); Embase. Once the literature review was completed, the authors identified the main diseases with tomographic repercussions and proposed the present system to evaluate cranial computed tomography images. An easy-to-memorize ABC system will facilitate the decision making in emergency settings, as it covers the main diseases encountered by intensivists and emergency physicians, and provides a sequential guidance about anatomical structures to be investigated as well as their respective alterations. (author)

  17. An ABC for decision making

    International Nuclear Information System (INIS)

    Garcia, Luiz Henrique Costa; Ferreira, Bruna Cortez

    2015-01-01

    The present study was aimed at proposing a systematic evaluation of cranial computed tomography, identifying the main aspects to be analyzed in order to facilitate the decision making process regarding diagnosis and management in emergency settings. The present descriptive study comprised a literature review at the following databases: Access Medicine and Access Emergency Medicine (McGraw-Hill Education); British Medical Journal Evidence Center; UptoDate; Bireme; PubMed; Lilacs; SciELO; ProQuest; Micromedex (Thomson Reuters); Embase. Once the literature review was completed, the authors identified the main diseases with tomographic repercussions and proposed the present system to evaluate cranial computed tomography images. An easy-to-memorize ABC system will facilitate the decision making in emergency settings, as it covers the main diseases encountered by intensivists and emergency physicians, and provides a sequential guidance about anatomical structures to be investigated as well as their respective alterations. (author)

  18. An ABC for decision making

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Costa Garcia

    2015-04-01

    Full Text Available The present study was aimed at proposing a systematic evaluation of cranial computed tomography, identifying the main aspects to be analyzed in order to facilitate the decision making process regarding diagnosis and management in emergency settings. The present descriptive study comprised a literature review at the following databases: Access Medicine and Access Emergency Medicine (McGraw- Hill Education; British Medical Journal Evidence Center; UptoDate; Bireme; PubMed; Lilacs; SciELO; ProQuest; Micromedex (Thomson Reuters; Embase. Once the literature review was completed, the authors identified the main diseases with tomographic repercussions and proposed the present system to evaluate cranial computed tomography images. An easy-to-memorize ABC system will facilitate the decision making in emergency settings, as it covers the main diseases encountered by intensivists and emergency physicians, and provides a sequential guidance about anatomical structures to be investigated as well as their respective alterations.

  19. Automatic Constraint Detection for 2D Layout Regularization.

    Science.gov (United States)

    Jiang, Haiyong; Nan, Liangliang; Yan, Dong-Ming; Dong, Weiming; Zhang, Xiaopeng; Wonka, Peter

    2016-08-01

    In this paper, we address the problem of constraint detection for layout regularization. The layout we consider is a set of two-dimensional elements where each element is represented by its bounding box. Layout regularization is important in digitizing plans or images, such as floor plans and facade images, and in the improvement of user-created contents, such as architectural drawings and slide layouts. To regularize a layout, we aim to improve the input by detecting and subsequently enforcing alignment, size, and distance constraints between layout elements. Similar to previous work, we formulate layout regularization as a quadratic programming problem. In addition, we propose a novel optimization algorithm that automatically detects constraints. We evaluate the proposed framework using a variety of input layouts from different applications. Our results demonstrate that our method has superior performance to the state of the art.

  20. Automatic Constraint Detection for 2D Layout Regularization

    KAUST Repository

    Jiang, Haiyong

    2015-09-18

    In this paper, we address the problem of constraint detection for layout regularization. As layout we consider a set of two-dimensional elements where each element is represented by its bounding box. Layout regularization is important for digitizing plans or images, such as floor plans and facade images, and for the improvement of user created contents, such as architectural drawings and slide layouts. To regularize a layout, we aim to improve the input by detecting and subsequently enforcing alignment, size, and distance constraints between layout elements. Similar to previous work, we formulate the layout regularization as a quadratic programming problem. In addition, we propose a novel optimization algorithm to automatically detect constraints. In our results, we evaluate the proposed framework on a variety of input layouts from different applications, which demonstrates our method has superior performance to the state of the art.

  1. Sediment yields of Wisconsin streams

    Science.gov (United States)

    Hindall, S.M.; Flint, R.F.

    1970-01-01

    Sediment in Wisconsin streams causes economic and engineering problems in water management and reduces the value of water for nearly all uses. Sediment produces problems such as reduced reservoir capacity, navigation hazards, increased cost of water treatment, property damage, temporary loss of farmland, destruction of feeding and nesting grounds of fish, and destruction of wildlife habitat. Sediment in water also reduces the aesthetic value of surface waters and is detrimental to the State's tourist and recreation industry.

  2. Isolation and Characterization of the Colletotrichum acutatum ABC Transporter CaABC1

    Directory of Open Access Journals (Sweden)

    Suyoung Kim

    2014-12-01

    Full Text Available Fungi tolerate exposure to various abiotic stresses, including cytotoxic compounds and fungicides, via their ATP-driven efflux pumps belonging to ATP-binding cassette (ABC transporters. To clarify the molecular basis of interaction between the fungus and various abiotic stresses including fungicides, we constructed a cDNA library from germinated conidia of Colletotrichum acutatum, a major anthracnose pathogen of pepper (Capsicum annum L.. Over 1,000 cDNA clones were sequenced, of which single clone exhibited significant nucleotide sequence homology to ABC transporter genes. We isolated three fosmid clones containing the C. acutatum ABC1 (CaABC1 gene in full-length from genomic DNA library screening. The CaABC1 gene consists of 4,059 bp transcript, predicting a 1,353-aa protein. The gene contains the typical ABC signature and Walker A and B motifs. The 5′-flanking region contains a CAAT motif, a TATA box, and a Kozak region. Phylogenetic and structural analysis suggested that the CaABC1 is a typical ABC transporter gene highly conserved in various fungal species, as well as in Chromista, Metazoans, and Viridiplantae. We also found that CaABC1 was up-regulated during conidiation and a minimal medium condition. Moreover, CaABC1 was induced in iprobenfos, kresoxim-methyl, thiophanate-methyl, and hygromycin B. These results demonstrate that CaABC1 is necessary for conidiation, abiotic stress, and various fungicide resistances. These results will provide the basis for further study on the function of ABC transporter genes in C. acutatum.

  3. 48 CFR 36.517 - Layout of work.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Layout of work. 36.517... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.517 Layout of work. The contracting officer shall insert the clause at 52.236-17, Layout of Work, in solicitations and contracts when...

  4. ABCs of Oral Health: Nutrition - Children

    Science.gov (United States)

    ... higher risk for heart attacks More ABCs of Oral Health A | B | C | D | E | F | G | H | ... Children Home | InfoBites | Find a Dentist | Your Family's Oral Health | RSS About AGD | Contact AGD | Site Map | Reprints ...

  5. Yeast ABC proteins involved in multidrug resistance.

    Science.gov (United States)

    Piecuch, Agata; Obłąk, Ewa

    2014-03-01

    Pleiotropic drug resistance is a complex phenomenon that involves many proteins that together create a network. One of the common mechanisms of multidrug resistance in eukaryotic cells is the active efflux of a broad range of xenobiotics through ATP-binding cassette (ABC) transporters. Saccharomyces cerevisiae is often used as a model to study such activity because of the functional and structural similarities of its ABC transporters to mammalian ones. Numerous ABC transporters are found in humans and some are associated with the resistance of tumors to chemotherapeutics. Efflux pump modulators that change the activity of ABC proteins are the most promising candidate drugs to overcome such resistance. These modulators can be chemically synthesized or isolated from natural sources (e.g., plant alkaloids) and might also be used in the treatment of fungal infections. There are several generations of synthetic modulators that differ in specificity, toxicity and effectiveness, and are often used for other clinical effects.

  6. Pure JavaScript Storyline Layout Algorithm

    Energy Technology Data Exchange (ETDEWEB)

    2017-10-02

    This is a JavaScript library for a storyline layout algorithm. Storylines are adept at communicating complex change by encoding time on the x-axis and using the proximity of lines in the y direction to represent interaction between entities. The library in this disclosure takes as input a list of objects containing an id, time, and state. The output is a data structure that can be used to conveniently render a storyline visualization. Most importantly, the library computes the y-coordinate of the entities over time that decreases layout artifacts including crossings, wiggles, and whitespace. This is accomplished through multi-objective, multi-stage optimization problem, where the output of one stage produces input and constraints for the next stage.

  7. Layout Drawings of the LHC Collider

    CERN Document Server

    Vergara Fernandez, A; Maire, B; Muttoni, Y; Kournossenko, A; Zalyalov, R

    2004-01-01

    The team in charge of the LHC integration largely uses 3D scenes combining functional positions of equipments and the 3D CAD model issued from the CERN Drawing Directory (CDD) repository. This is made possible through the Digital Mock-Up tool developed at CERN. Giving dimensions in 3D context is a challenge with the current 3D CAD tools used at CERN. Requirements from users groups have made clear a need for automatic production of 2D layout drawings. This paper presents the retained solution to create on-request dimensioned drawings, to publish them, while maintaining coherence and consistency with the 3D integration scenes. Reliability of the information, on-line availability of the latest layout changes on dimensions and positions of equipments, and the maintenance of the facility is also described.

  8. Layout drawings of the LHC collider

    CERN Document Server

    Vergara, A

    2004-01-01

    The team in charge of the LHC integration largely uses 3D scenes combining functional positions of equipments and the 3D CAD model issued from the CERN Drawing Directory (CDD) repository. This is made possible through the Digital Mock-Up tool developed at CERN. Giving dimensions in 3D context is a challenge with the current 3D CAD tools used at CERN. Requirements from users groups have made clear a need for automatic production of 2D layout drawings. This paper presents the retained solution to create on-request dimensioned drawings, to publish them, while maintaining coherence and consistency with the 3D integration scenes. Reliability of the information, on-line availability of the latest layout changes on dimensions and positions of equipments, and the maintenance of the facility will also be described.

  9. ABC Inventory classification application: Özdemirler

    OpenAIRE

    Duru, Mehmet

    1989-01-01

    Ankara : The Department of Management and the Institute of Management Sciences of Bilkent Univ. , 1989. Thesis (Master's) -- Bilkent University, 1989. Includes bibliographical references leaves 37. ABC inventory classification can result in more effective control of business. In this work, ABC method is applied to Ozdemirler to examine the inventory profile of the store, and to be able to aid the management in allocating control effort among items more effectively. Dur...

  10. Ergonomic Application on the Work Station Layout

    International Nuclear Information System (INIS)

    Suharyo Widagdo; Darlis

    2003-01-01

    Work station layout in the ideal way has been made. The dimension of the work station is 9.4 m x 7.1 m. The workers to be stationed should feel comfort. This can be done by honoring the dimensions and the sum of the tools that should be stationed and also the free space that should be mention between the tools as state in EPRI, NP-2411. (author)

  11. CLASSIFICATION OF THE MGR SITE LAYOUT SYSTEM

    International Nuclear Information System (INIS)

    S.E. Salzman

    1999-01-01

    The purpose of this analysis is to document the Quality Assurance (QA) classification of the Monitored Geologic Repository (MGR) site layout system structures, systems and components (SSCs) performed by the MGR Safety Assurance Department. This analysis also provides the basis for revision of YMP/90-55Q, Q-List (YMP 1998). The Q-List identifies those MGR SSCs subject to the requirements of DOE/RW-0333P, ''Quality Assurance Requirements and Description'' (QARD) (DOE 1998)

  12. Inverse procedural modeling of facade layouts

    KAUST Repository

    Wu, Feng

    2014-07-22

    In this paper, we address the following research problem: How can we generate a meaningful split grammar that explains a given facade layout? To evaluate if a grammar is meaningful, we propose a cost function based on the description length and minimize this cost using an approximate dynamic programming framework. Our evaluation indicates that our framework extracts meaningful split grammars that are competitive with those of expert users, while some users and all competing automatic solutions are less successful. Copyright © ACM.

  13. Probabilistic Graph Layout for Uncertain Network Visualization.

    Science.gov (United States)

    Schulz, Christoph; Nocaj, Arlind; Goertler, Jochen; Deussen, Oliver; Brandes, Ulrik; Weiskopf, Daniel

    2017-01-01

    We present a novel uncertain network visualization technique based on node-link diagrams. Nodes expand spatially in our probabilistic graph layout, depending on the underlying probability distributions of edges. The visualization is created by computing a two-dimensional graph embedding that combines samples from the probabilistic graph. A Monte Carlo process is used to decompose a probabilistic graph into its possible instances and to continue with our graph layout technique. Splatting and edge bundling are used to visualize point clouds and network topology. The results provide insights into probability distributions for the entire network-not only for individual nodes and edges. We validate our approach using three data sets that represent a wide range of network types: synthetic data, protein-protein interactions from the STRING database, and travel times extracted from Google Maps. Our approach reveals general limitations of the force-directed layout and allows the user to recognize that some nodes of the graph are at a specific position just by chance.

  14. Production layout improvement by using line balancing and Systematic Layout Planning (SLP) at PT. XYZ

    Science.gov (United States)

    Buchari; Tarigan, U.; Ambarita, M. B.

    2018-02-01

    PT. XYZ is a wood processing company which produce semi-finished wood with production system is make to order. In the production process, it can be seen that the production line is not balanced. The imbalance of the production line is caused by the difference in cycle time between work stations. In addition, there are other issues, namely the existence of material flow pattern is irregular so it resulted in the backtracking and displacement distance away. This study aimed to obtain the allocation of work elements to specific work stations and propose an improvement of the production layout based on the result of improvements in the line balancing. The method used in the balancing is Ranked Positional Weight (RPW) or also known as Helgeson Birnie method. While the methods used in the improvement of the layout is the method of Systematic Layout Planning (SLP). By using Ranked Positional Weight (RPW) obtained increase in line efficiency becomes 84,86% and decreased balance delay becomes 15,14%. Repairing the layout using the method of Systematic Layout Planning (SLP) also give good results with a reduction in path length becomes 133,82 meters from 213,09 meters previously or a decrease of 37.2%.

  15. A REDESIGN LAYOUT TO INCREASE PRODUCTIVITY OF A COMPANY

    Directory of Open Access Journals (Sweden)

    Vincentia Kitriastika

    2013-06-01

    Full Text Available This project is conducted in Company X, a passenger cars wheel producing company located in Sunter, North Jakarta. With a view of increasing the productivity of the company, the focus of this project will be redesigned the layout of the factory. The main problem encountered is that the goods are not produced in single location, causing a considerable hindrance in terms of time and distance, and hence efficiency. The redesigning layout process will use SLP method and flow analysis while supported by analysis of assembly line balancing to optimize the layout. Regarding the evaluation process, ARENA software will be used to simulate and identify the bottleneck in the production process, and comparing the layout alternatives to decide the best layout. The best chosen layout according to the simulation and SLP method that supported with flow analysis and assembly line balancing will be used as the master draft layout that will be proposed to Company X.

  16. Water Use in Wisconsin, 2005

    Science.gov (United States)

    Buchwald, Cheryl A.

    2009-01-01

    The U.S. Geological Survey (USGS) Wisconsin Water Science Center is responsible for presenting data collected or estimated for water withdrawals and diversions every 5 years to the National Water-Use Information Program (NWUIP). This program serves many purposes such as quantifying how much, where, and for what purpose water is used; tracking and documenting water-use trends and changes; and providing these data to other agencies to support hydrologic projects. In 2005, data at both the county and subbasin levels were compiled into the USGS national water-use database system; these data are published in a statewide summary report and a national circular. This publication, Water Use in Wisconsin, 2005, presents the water-use estimates for 2005; this publication also describes how these water-use data were determined (including assumptions used), limitations of using these data, and trends in water-use data presented to the NWUIP. Estimates of water use in Wisconsin indicate that about 8,608 million gallons per day (Mgal/d) were withdrawn during 2005. Of this amount, about 7,622 Mgal/d (89 percent) were from surface-water sources and about 986 Mgal/d (11 percent) were from ground-water sources. Surface water used for cooling at thermoelectric-power plants constituted the largest portion of daily use at 6,898 Mgal/d. Water provided by public-supply water utilities is the second largest use of water and totaled 552 Mgal/d. Public supply served approximately 71 percent of the estimated 2005 Wisconsin population of 5.54 million people; two counties - Milwaukee and Dane - accounted for more than one-third of the public-supply withdrawal. Industrial and irrigation were the next major water uses at 471 and 402 Mgal/d, respectively. Non-irrigational agricultural (livestock and aquaculture) accounted for approximately 155 Mgal/d and is similar to the combined withdrawal for the remaining water-use categories of domestic, commercial, and mining (131 Mgal/d). Data on water use

  17. Improving mobility for Wisconsin's elderly : brief.

    Science.gov (United States)

    2011-10-01

    By 2035, the number of elderly residents in Wisconsin is expected to nearly double, and one in four drivers on Wisconsin roads will be elderly. According to national statistics, the elderly are more likely to be involved in crashes on a per-mile basi...

  18. General layout of a 1300 MW PWR buildings: standard lay-out and influence factors

    International Nuclear Information System (INIS)

    Silva Messias, M. da

    1986-01-01

    The Standardization concept of a 1300 MW Nuclear Power Plant equipped with pressurized-water reactors (PWR) will be considered with regard to the factors which have various degrees of influence on the Layout of the Site. Standardization with regard to the Layout of nuclear power plant, stands, however also for a fixed arrangement of the components in the main buildings and a fixed arrangement of the buildings in the site plan. Standardization may result in simplified and shorter licensing procedures and mean less planning effort. Concentration of systems, optimization of the electro-mechanical design, clear separation of the controlled area, need for shielding, maintenance and safety aspects are some of number of factors which have various degress of influence on the layout of the buildings. (Author) [pt

  19. Repository surface design site layout analysis

    International Nuclear Information System (INIS)

    Montalvo, H.R.

    1998-01-01

    The purpose of this analysis is to establish the arrangement of the Yucca Mountain Repository surface facilities and features near the North Portal. The analysis updates and expands the North Portal area site layout concept presented in the ACD, including changes to reflect the resizing of the Waste Handling Building (WHB), Waste Treatment Building (WTB), Carrier Preparation Building (CPB), and site parking areas; the addition of the Carrier Washdown Buildings (CWBs); the elimination of the Cask Maintenance Facility (CMF); and the development of a concept for site grading and flood control. The analysis also establishes the layout of the surface features (e.g., roads and utilities) that connect all the repository surface areas (North Portal Operations Area, South Portal Development Operations Area, Emplacement Shaft Surface Operations Area, and Development Shaft Surface Operations Area) and locates an area for a potential lag storage facility. Details of South Portal and shaft layouts will be covered in separate design analyses. The objective of this analysis is to provide a suitable level of design for the Viability Assessment (VA). The analysis was revised to incorporate additional material developed since the issuance of Revision 01. This material includes safeguards and security input, utility system input (size and location of fire water tanks and pump houses, potable water and sanitary sewage rates, size of wastewater evaporation pond, size and location of the utility building, size of the bulk fuel storage tank, and size and location of other exterior process equipment), main electrical substation information, redundancy of water supply and storage for the fire support system, and additional information on the storm water retention pond

  20. Repository Surface Design Site Layout Analysis

    International Nuclear Information System (INIS)

    Montalvo, H.R.

    1998-01-01

    The purpose of this analysis is to establish the arrangement of the Repository surface facilities and features near the North Portal. The analysis updates and expands the North Portal area site layout concept presented in the ACD (Reference 5.5), including changes to reflect the resizing of the Waste Handling Building (WHB), Waste Treatment Building (WTB), Carrier Preparation Building (CPB), and site parking areas; the addition of the Carrier Washdown Buildings (CWBs); the elimination of the Cask Maintenance Facility (CMF); and the development of a concept for site grading and flood control. The analysis also establishes the layout of the surface features (e.g., roads and utilities) that connect all the repository surface areas (North Portal Operations Area, South Portal Development Operations Area, Emplacement Shaft Surface Operations Area, and Development Shaft Surface Operations Area) and locates an area for a potential lag storage facility. Details of South Portal and shaft layouts will be covered in separate design analyses. The objective of this analysis is to provide a suitable level of design for the Viability Assessment (VA). The analysis was revised to incorporate additional material developed since the issuance of Revision 01. This material includes safeguards and security input, utility system input (size and location of fire water tanks and pump houses, potable water and sanitary sewage rates, size of wastewater evaporation pond, size and location of the utility building, size of the bulk fuel storage tank, and size and location of other exterior process equipment), main electrical substation information, redundancy of water supply and storage for the fire support system, and additional information on the storm water retention pond

  1. Hierarchically organized layout for visualization of biochemical pathways.

    Science.gov (United States)

    Tsay, Jyh-Jong; Wu, Bo-Liang; Jeng, Yu-Sen

    2010-01-01

    Many complex pathways are described as hierarchical structures in which a pathway is recursively partitioned into several sub-pathways, and organized hierarchically as a tree. The hierarchical structure provides a natural way to visualize the global structure of a complex pathway. However, none of the previous research on pathway visualization explores the hierarchical structures provided by many complex pathways. In this paper, we aim to develop algorithms that can take advantages of hierarchical structures, and give layouts that explore the global structures as well as local structures of pathways. We present a new hierarchically organized layout algorithm to produce layouts for hierarchically organized pathways. Our algorithm first decomposes a complex pathway into sub-pathway groups along the hierarchical organization, and then partition each sub-pathway group into basic components. It then applies conventional layout algorithms, such as hierarchical layout and force-directed layout, to compute the layout of each basic component. Finally, component layouts are joined to form a final layout of the pathway. Our main contribution is the development of algorithms for decomposing pathways and joining layouts. Experiment shows that our algorithm is able to give comprehensible visualization for pathways with hierarchies, cycles as well as complex structures. It clearly renders the global component structures as well as the local structure in each component. In addition, it runs very fast, and gives better visualization for many examples from previous related research. 2009 Elsevier B.V. All rights reserved.

  2. Draft layout of the HPLWR power plant

    Energy Technology Data Exchange (ETDEWEB)

    Koehly, C. [Karlsruhe Inst. of Tech., Karlsruhe (Germany); Starflinger, J. [IKE, Univ. of Stuttgart (Germany); Schulenberg, T.; Brandauer, M.; Lemasson, D.; Velluet, R. [Karlsruhe Inst. of Tech., Karlsruhe (Germany); Herbell, H. [EnBW Kernkraft GmbH, Kernkraftwerk Philippsburg (Germany)

    2011-07-01

    The High Performance Light Water Reactor (HPLWR) is a Supercritical Water Cooled Reactor designed by a consortium of European partners in the 6th European Framework Programme. This paper describes a potential layout of the reactor building including the containment with the reactor and with the required safety systems, the turbine building with turbines, condensers, feedwater pumps and preheaters, and the start-up system. Design details are given for selected key components to estimate their size. Compared with a conventional power plant of similar power output, the HPLWR power plant can be designed significantly smaller. (author)

  3. Methodology of shell structure reinforcement layout optimization

    Science.gov (United States)

    Szafrański, Tomasz; Małachowski, Jerzy; Damaziak, Krzysztof

    2018-01-01

    This paper presents an optimization process of a reinforced shell diffuser intended for a small wind turbine (rated power of 3 kW). The diffuser structure consists of multiple reinforcement and metal skin. This kind of structure is suitable for optimization in terms of selection of reinforcement density, stringers cross sections, sheet thickness, etc. The optimisation approach assumes the reduction of the amount of work to be done between the optimization process and the final product design. The proposed optimization methodology is based on application of a genetic algorithm to generate the optimal reinforcement layout. The obtained results are the basis for modifying the existing Small Wind Turbine (SWT) design.

  4. ATLAS ITk Layout Design and Optimisation

    CERN Document Server

    Calace, Noemi; The ATLAS collaboration

    2016-01-01

    Detector design studies are a very crucial activity for the ATLAS Collaboration, in preparation for the future High Luminosity LHC (HL-LHC) planned to start in 2026. One of the key activities is the design and prototyping of a new Inner Tracker (ITk), fully made of silicon, able to meet the requirements HL-LHC environment assuring at the same time very high tracking performance. A dedicated design process started from Letter of Intent (LoI) layouts is still ongoing to establish the design ATLAS ITk tracker.

  5. Yeast ABC transporters in lipid trafficking.

    Science.gov (United States)

    Prasad, Rajendra; Khandelwal, Nitesh Kumar; Banerjee, Atanu

    2016-08-01

    Throughout its evolution, the ATP-binding cassette (ABC) transporter superfamily has experienced a rapid expansion in its substrate repertoire and functions. Of the diverse functions that these pumps offer, their drug transport properties have attracted considerable attention primarily owing to their clinical significance. Despite this fact, emerging evidence suggests that physiological substrates of transporters also affect the overall functioning of an organism. Lipids, as substrates of ABC transporters, constitute one feature found in all representative groups of the living kingdom. Due to the importance of lipid species in the cellular physiology of an organism, their proper distribution within cells is crucial. This fact is well exemplified by the vast number of medical conditions that have been caused as a result of perturbations in ABC transporter-mediated lipid transport in higher organisms. In yeasts, apart from providing transport functions, ABC transporters also coordinate regulatory networks with lipids. This review focuses on yeast ABC transporters involved in the transport of lipids and briefly discusses the integration of their regulatory network with that of the lipid species. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. abc: An extensible AspectJ compiler

    DEFF Research Database (Denmark)

    Avgustinov, Pavel; Christensen, Aske Simon; Hendren, Laurie

    2005-01-01

    Research in the design of aspect-oriented programming languages requires a workbench that facilitates easy experimentation with new language features and implementation techniques. In particular, new features for AspectJ have been proposed that require extensions in many dimensions: syntax, type...... checking and code generation, as well as data flow and control flow analyses. The AspectBench Compiler (abc) is an implementation of such a workbench. The base version of abc implements the full AspectJ language. Its frontend is built, using the Polyglot framework, as a modular extension of the Java...... language. The use of Polyglot gives flexibility of syntax and type checking. The backend is built using the Soot framework, to give modular code generation and analyses. In this paper, we outline the design of abc, focusing mostly on how the design supports extensibility. We then provide a general overview...

  7. Evolutionary optimization technique for site layout planning

    KAUST Repository

    El Ansary, Ayman M.

    2014-02-01

    Solving the site layout planning problem is a challenging task. It requires an iterative approach to satisfy design requirements (e.g. energy efficiency, skyview, daylight, roads network, visual privacy, and clear access to favorite views). These design requirements vary from one project to another based on location and client preferences. In the Gulf region, the most important socio-cultural factor is the visual privacy in indoor space. Hence, most of the residential houses in this region are surrounded by high fences to provide privacy, which has a direct impact on other requirements (e.g. daylight and direction to a favorite view). This paper introduces a novel technique to optimally locate and orient residential buildings to satisfy a set of design requirements. The developed technique is based on genetic algorithm which explores the search space for possible solutions. This study considers two dimensional site planning problems. However, it can be extended to solve three dimensional cases. A case study is presented to demonstrate the efficiency of this technique in solving the site layout planning of simple residential dwellings. © 2013 Elsevier B.V. All rights reserved.

  8. Geometric properties of graph layouts optimized for greedy navigation.

    Science.gov (United States)

    Lee, Sang Hoon; Holme, Petter

    2012-12-01

    The graph layouts used for complex network studies have been mainly developed to improve visualization. If we interpret the layouts in metric spaces such as Euclidean ones, however, the embedded spatial information can be a valuable cue for various purposes. In this work, we focus on encoding useful navigational information to geometric coordinates of vertices of spatial graphs, which is a reverse problem of harnessing geometric information for better navigation. In other words, the coordinates of the vertices are a map of the topology, not the other way around. We use a recently developed user-centric navigation protocol to explore spatial layouts of complex networks that are optimal for navigation. These layouts are generated with a simple simulated annealing optimization technique. We compare these layouts to others targeted at better visualization and discuss the spatial statistical properties of the optimized layouts for better navigability and its implication.

  9. ABC model and the management of costs

    Directory of Open Access Journals (Sweden)

    Pravdić Predrag

    2016-01-01

    Full Text Available When a company has multiple objectives at the same time, they all must be considered and balanced when making any business decisions. Linking the markets, capital and resources so as to thus ensure the highest yield is, In fact, the search for competitive advantage as a basic condition for survival in a market economy. In highly detailed systems based on the management of costs or ABC (activity based costing systems, the cost of activities often result in erroneous evaluation of aggregate costs of the action. Improvements in information technology and monitoring decrease of technology costs enabled the ABC system to become a feasible system calculating costs in many organizations.

  10. Three-dimensional computer aided design system for plant layout

    International Nuclear Information System (INIS)

    Yoshinaga, Toshiaki; Kiguchi, Takashi; Tokumasu, Shinji; Kumamoto, Kenjiro.

    1986-01-01

    The CAD system for three-dimensional plant layout planning, with which the layout of pipings, cable trays, air conditioning ducts and so on in nuclear power plants can be planned and designed effectively in a short period is reported. This system comprises the automatic routing system by storing the rich experience and know-how of designers in a computer as the knowledge, and deciding the layout automatically following the predetermined sequence by using these, the interactive layout system for reviewing the routing results from higher level and modifying to the optimum layout, the layout evaluation system for synthetically evaluating the layout from the viewpoint of the operability such as checkup and maintenance, and the data base system which enables these effective planning and design. In this report, the total constitution of this system and the technical features and effects of the individual subsystems are outlined. In this CAD system for three-dimensional plant layout planning, knowledge engineering, CAD/CAM, computer graphics and other latest technology were introduced, accordingly by applying this system to plant design, the design can be performed quickly, various case studies can be carried out at planning stage, and systematic and optimum layout planning becomes possible. (Kako, I.)

  11. The Offshore Wind Farm Array Cable Layout Problem

    DEFF Research Database (Denmark)

    Bauer, Joanna; Lysgaard, Jens

    2014-01-01

    In an offshore wind farm (OWF), the turbines are connected to a transformer by cable routes that cannot cross each other. Finding the minimum cost array cable layout thus amounts to a vehicle routing problem with the additional constraints that the routes must be embedded in the plane. For this p......In an offshore wind farm (OWF), the turbines are connected to a transformer by cable routes that cannot cross each other. Finding the minimum cost array cable layout thus amounts to a vehicle routing problem with the additional constraints that the routes must be embedded in the plane....... For this problem, both exact and heuristic methods are of interest. We optimize cable layouts for real-world OWFs by a hop-indexed integer programming formulation, and develop a heuristic for computing layouts based on the Clarke and Wright savings heuristic for vehicle routing. Our heuristic computes layouts...... on average only 2% more expensive than the optimal layout. Finally, we present two problem extensions arising from real-world OWF cable layouts, and adapt the integer programming formulation to one of them. The thus obtained optimal layouts are up to 13% cheaper than the actually installed layouts....

  12. ABC transporters : Lessons from a bacterial oligopeptide uptake system

    NARCIS (Netherlands)

    Doeven, Mark Koop

    2006-01-01

    ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases. Too high ABC transporter activity can lead to non-responsiveness of cancercells to chemotherapy, and

  13. The ABC-paradox: is Time Driven ABC relevant for small and Medium sized enterprises (SME)?

    DEFF Research Database (Denmark)

    Fladkjær, Henrik Find; Jensen, Erling

    -books and in curriculum at most business schools. But ABC is not used very much by the compa-nies. Especially in small and medium enterprises ABC is rarely implemented. This is primarily due to two things: First, the ABC model is too difficult to implement. Second, the data foundation for the model is not available...... in the required quality in the ERP systems used by the businesses. In this article we will explore ways of overcoming these two related problems. We will explore these issues particularly in relation to small and medium enterprises. Through a theoretical analysis and practical implementation in a medium sized...... manufacturing company we will analyse whether it is possible to create a satisfactory decision making foundation using a TDABC as a less complex cost model in the company. We have analysed our way to the conclusion that compared to ABC, the TDABC model provides the management with a number of pragmatic...

  14. Addressing elderly mobility issues in Wisconsin.

    Science.gov (United States)

    2011-09-01

    "The aging of baby boomers poses significant challenges to Wisconsins existing transportation infrastructure and specialized transit : programs. From 2010 to 2035, the number of elderly Wisconsinites is projected to grow by 90 percent, an increase...

  15. Predicting Scour of Bedrock in Wisconsin

    Science.gov (United States)

    2017-04-01

    This research evaluates the scour potential of rocks supporting Wisconsin DOT bridge foundations. Ten highway bridges were selected for this study, of which seven are supported by shallow foundations, and five were built on sandstone in rivers/stream...

  16. Fuelwood production and sources in Wisconsin, 1981.

    Science.gov (United States)

    James E. Blyth; E. Michael Bailey; W. Brad Smith

    1984-01-01

    Discusses and analyzes the 1981 Wisconsin fuelwood production from roundwood and primary wood-using mill residue. Analyzes production by geographic area, type of producer, species, landowner class, type of land, and tree source.

  17. ITER layout: Alternatives for improved maintenance

    International Nuclear Information System (INIS)

    Blevins, J.; Barnes, C.; Maisonnier, D.

    1991-01-01

    International Thermonuclear Experimental Reactor maintenance mission objectives and their effect on systems layout are reviewed through the example of the torus vacuum pumping system. Applying maintenance requirements to this system has resulted in significant improvements in component accessibility. Further changes currently under review could result in a reduction in vacuum duct length, the addition of duct shielding to reduce neutron activation, a pump and valve assembly which can be serviced from the floor rather than solely from a crane, and provision for transport casks to enter the pump room through an equipment airlock, large enough to permit the entry of robotic devices as well as construction equipment. This rearrangement could offer savings in overall height of the pump and valve assembly. An innovation in valve configuration will allow for one-line removal of the large vacuum valve seal discs without loss of vacuum. This has potential for reduced maintenance outage time and operating cost. (orig.)

  18. Ergonomics influence on control room layout

    International Nuclear Information System (INIS)

    Hartfiel, H.D.

    1984-01-01

    Nowadays, human factors has become an important aspect of the design of work places. Since the control room in a nuclear power plant is a work place, too, its layout is also influenced by ergonomics. With the KWU control room concept for the 1300 MW PWR as an example, we show how assured and applicable ergonomic findings enter into the control room design. On the basis of general design principles for work places, specific methods for control room planning have been developed. By working with these methods a concept that makes it possible to build a man-machine interface able to fulfill the process control tasks with all their underlying conditions has been derived. (author)

  19. Procedural facade variations from a single layout

    KAUST Repository

    Bao, Fan

    2013-02-19

    We introduce a framework to generate many variations of a facade design that look similar to a given facade layout. Starting from an input image, the facade is hierarchically segmented and labeled with a collection of manual and automatic tools. The user can then model constraints that should be maintained in any variation of the input facade design. Subsequently, facade variations are generated for different facade sizes, where multiple variations can be produced for a certain size. Computing such new facade variations has many unique challenges, and we propose a new algorithm based on interleaving heuristic search and quadratic programming. In contrast to most previous work, we focus on the generation of new design variations and not on the automatic analysis of the input\\'s structure. Adding a modeling step with the user in the loop ensures that our results routinely are of high quality. © 2013 ACM.

  20. Step 2: Know Your Diabetes ABCs

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: Type 2 Diabetes Step 2: Know Your Diabetes ABCs Past Issues / Fall 2014 Table of Contents ... cholesterol helps remove cholesterol from your blood vessels. Diabetes HealthSense Find tools and programs that can help ...

  1. ABC – Advocates for Breast Cancer

    African Journals Online (AJOL)

    Cancer 2008;113(S8):221-224. [http://dx.doi.org/10.1002/cncr.23844]. ARTICLE. ABC – Advocates for Breast Cancer. A Steyn,1 Dip DA (Lond), LRAM (Speech and Drama) (Lond); J du Plessis;2 S Meyer,3 MSocSc (SW). 1 Immediate Past President, Reach to Recovery International, Queensland, Australia. 2 Chief Executive ...

  2. Phylogenetic analysis of fungal ABC transporters

    NARCIS (Netherlands)

    Kovalchuk, Andriy; Driessen, Arnold J. M.

    2010-01-01

    Background: The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The

  3. Importance of ABC Transporters in Drug Development.

    Science.gov (United States)

    Benadiba, Marcel; Maor, Yehoshua

    2016-01-01

    ATP-binding cassette (ABC) transporters are a huge family of ATP-dependent transmembrane proteins whose main function is exporting or importing substances or molecules through the cell membranes, plasma cell membrane, or inner membranes in organelles. They fulfill these functions by maintaining cell integrity, metabolism, and homeostasis. They are expressed in a variety of tissues as they transport numerous essential compounds including lipids and other signaling molecules. ABC transporters became widely studied since the discovery of their ability to carry a multitude of xenobiotics, including therapeutic drugs, and in light of the fact that they represent a hurdle for the treatment of resistant cancers. In contrast, the role of ABC transporters in neurological diseases like Alzheimer`s and Parkinson`s, depression, schizophrenia, and epilepsy remains controversial and their mechanism of action in these pathologies remains elusive, thus hindering the implementation of therapies aimed at modulating the functions of these transporters. To date, a number of natural and synthetic compounds are known to act as inhibitors, substrates, and even inducers of these transporters, being able to modulate their expression and/or function; however, their implication as therapeutic agents is far from reaching wide clinical utilization. This review highlights the importance of overcoming the challenges posed by ABC transporters in drug development.

  4. Underground design Laxemar, Layout D2

    Energy Technology Data Exchange (ETDEWEB)

    2009-11-15

    Laxemar candidate area is located in the province of Smaaland, some 320 km south of Stockholm. The area is located close to the shoreline of the Baltic Sea and is within the municipality of Oskarshamn, and immediately west of the Oskarshamn nuclear power plant and the Central interim storage facility for spent fuel (Clab). The easternmost part (Simpevarp subarea) includes the Simpevarp peninsula, which hosts the power plants and the Clab facility. The island of Aespoe, containing the Aespoe Hard Rock Laboratory is located some three kilometres northeast of the central parts of Laxemar. The Laxemar subarea covers some 12.5 km2, compared with the Simepvarp subarea, which is approximately 6.6 km2. The Laxemar candidate area has been investigated in stages, referred to as the initial site investigations (ISI) and the complete site investigations (CSI). These investigations commenced in 2002 and were completed in 2008. During the site investigations, several studies and design steps (D0, D1 and D2) were carried out to ensure that sufficient space was available for the 6,000-canister layout within the target volume at a depth of approximately 500 m. The findings from design Step D2 for the underground facilities including the access ramp, shafts, rock caverns in a Central Area, transport tunnels, and deposition tunnels and deposition holes are contained in this report. The layout for these underground excavations at the deposition horizon requires an area of 5.7 km2, and the total rock volume to be excavated is 3,008 x 103 m3 using a total tunnel length of approximately 115 km. The behaviour of the underground openings associated with this layout is expected to be similar to the behaviour of other underground openings in the Scandinavian shield at similar depths. The dominant mode of instability is expected to be structurally controlled wedge failure. Stability of the openings will be achieved with traditional underground rock support and by orienting the openings

  5. ABC transporters in fish species: a review

    Directory of Open Access Journals (Sweden)

    Marta eFerreira

    2014-07-01

    Full Text Available ATP-binding cassette (ABC proteins were first recognized for their role in multidrug resistance (MDR in chemotherapeutic treatments, which is a major impediment for the successful treatment of many forms of malignant tumors in humans. These proteins, highly conserved throughout vertebrate species, were later related to cellular detoxification and accounted as responsible for protecting aquatic organisms from xenobiotic insults in the so-called multixenobiotic resistance mechanism (MXR. In recent years, research on these proteins in aquatic species has highlighted their importance in the detoxification mechanisms in fish thus it is of extreme added value to continue these studies. Several transporters have been pointed out as relevant in the ecotoxicological context associated to the transport of xenobiotics, such as P-glycoproteins (Pgps, multidrug-resistance-associated proteins (MRPs 1-5 and breast resistance associated protein (BCRP. In mammals, several nuclear receptors have been identified as mediators of phase I and II metabolizing enzymes and ABC transporters. In aquatic species, knowledge on co-regulation of detoxification mechanism is scarce and needs to be addressed. The interaction of emergent contaminants, with chemosensitizer potential, with ABC transporters in aquatic organisms can compromise detoxification processes and have population effects and should be studied in more detail. This review intends to summarize the recent advances in research on MXR mechanisms in fish species, focusing in 1 regulation and functioning of ABC proteins; 2 cooperation with phase I and II biotransformation enzymes; and 3 ecotoxicological relevance and information on emergent pollutants with ability to modulate ABC transporters expression and activity. Several lines of evidence are clear suggesting the important role of these transporters in detoxification mechanisms and must be further investigated in fish.

  6. Simulation Modeling of a Facility Layout in Operations Management Classes

    Science.gov (United States)

    Yazici, Hulya Julie

    2006-01-01

    Teaching quantitative courses can be challenging. Similarly, layout modeling and lean production concepts can be difficult to grasp in an introductory OM (operations management) class. This article describes a simulation model developed in PROMODEL to facilitate the learning of layout modeling and lean manufacturing. Simulation allows for the…

  7. Factors driving firm's spatial decisions on distribution channel layout

    NARCIS (Netherlands)

    Onstein, A.T.C.; Ektesaby, M.; Rezaei, J.; Tavasszy, L.A.; van Damme, D.A.

    2017-01-01

    Spatial decisions on distribution channel layout involve the layout of the transport and storage system between production and consumption as well as the selection of distribution centre locations. Both are strategic company decisions to meet logistics challenges, i.e. delivering the right product

  8. Optimal layout of radiological environment monitoring based on TOPSIS method

    International Nuclear Information System (INIS)

    Li Sufen; Zhou Chunlin

    2006-01-01

    TOPSIS is a method for multi-objective-decision-making, which can be applied to comprehensive assessment of environmental quality. This paper adopts it to get the optimal layout of radiological environment monitoring, it is proved that this method is a correct, simple and convenient, practical one, and beneficial to supervision departments to scientifically and reasonably layout Radiological Environment monitoring sites. (authors)

  9. Developing an Integrated Design Strategy for Chip Layout Optimization

    NARCIS (Netherlands)

    Wits, Wessel Willems; Jauregui Becker, Juan Manuel; van Vliet, Frank Edward; te Riele, G.J.

    2011-01-01

    This paper presents an integrated design strategy for chip layout optimization. The strategy couples both electric and thermal aspects during the conceptual design phase to improve chip performances; thermal management being one of the major topics. The layout of the chip circuitry is optimized

  10. Layout and cabling considerations for a large communications antenna array

    Science.gov (United States)

    Logan, R. T., Jr.

    1993-01-01

    Layout considerations for a large deep space communications antenna array are discussed. A fractal geometry for the antenna layout is described that provides optimal packing of antenna elements, efficient cable routing, and logical division of the array into identical sub-arrays.

  11. Mental Layout Extrapolations Prime Spatial Processing of Scenes

    Science.gov (United States)

    Gottesman, Carmela V.

    2011-01-01

    Four experiments examined whether scene processing is facilitated by layout representation, including layout that was not perceived but could be predicted based on a previous partial view (boundary extension). In a priming paradigm (after Sanocki, 2003), participants judged objects' distances in photographs. In Experiment 1, full scenes (target),…

  12. Selecting a pharmacy layout design using a weighted scoring system.

    Science.gov (United States)

    McDowell, Alissa L; Huang, Yu-Li

    2012-05-01

    A weighted scoring system was used to select a pharmacy layout redesign. Facilities layout design techniques were applied at a local hospital pharmacy using a step-by-step design process. The process involved observing and analyzing the current situation, observing the current available space, completing activity flow charts of the pharmacy processes, completing communication and material relationship charts to detail which areas in the pharmacy were related to one another and how they were related, researching applications in other pharmacies or in scholarly works that could be beneficial, numerically defining space requirements for areas within the pharmacy, measuring the available space within the pharmacy, developing a set of preliminary designs, and modifying preliminary designs so they were all acceptable to the pharmacy staff. To select a final layout that could be implemented in the pharmacy, those layouts were compared via a weighted scoring system. The weighted aspect further allowed additional emphasis on categories based on their effect on pharmacy performance. The results produced a beneficial layout design as determined through simulated models of the pharmacy operation that more effectively allocated and strategically located space to improve transportation distances and materials handling, employee utilization, and ergonomics. Facilities layout designs for a hospital pharmacy were evaluated using a weighted scoring system to identify a design that was superior to both the current layout and alternative layouts in terms of feasibility, cost, patient safety, employee safety, flexibility, robustness, transportation distance, employee utilization, objective adherence, maintainability, usability, and environmental impact.

  13. Optimization of machining fixture layout for tolerance requirements ...

    African Journals Online (AJOL)

    Dimensional accuracy of workpart under machining is strongly influenced by the layout of the fixturing elements like locators and clamps. Setup or geometrical errors in locators result in overall machining error of the feature under consideration. Therefore it is necessary to ensure that the layout is optimized for the desired ...

  14. Student Perceptions of Textbook Layout and Learnability in Private Schools

    Science.gov (United States)

    Hoshangabadwala, Alefiyah

    2015-01-01

    This research is an exploratory study that investigates students' perceptions pertinent to textbook layout and organization and their evaluation of the textbook ease of learning. The objective is to find out whether the layout dynamics of school textbooks make any difference in students' interest in studying or subject understanding. 73 students…

  15. Layout Geometry in Encoding and Retrieval of Spatial Memory

    Science.gov (United States)

    Mou, Weimin; Liu, Xianyun; McNamara, Timothy P.

    2009-01-01

    Two experiments investigated whether the spatial reference directions that are used to specify objects' locations in memory can be solely determined by layout geometry. Participants studied a layout of objects from a single viewpoint while their eye movements were recorded. Subsequently, participants used memory to make judgments of relative…

  16. Layout Of Antennas And Cables In A Large Array

    Science.gov (United States)

    Logan, Ronald T., Jr.

    1995-01-01

    Layout devised to minimize total land area occupied by large phased array of antennas and to minimize total length of cables in array. In original intended application, array expanded version of array of paraboloidal-dish microwave communication antennas of Deep Space Network. Layout also advantageous for other phased arrays of antennas and antenna elements, including notably printed-circuit microwave antenna arrays.

  17. DSS 13 phase 2 pedestal room microwave layout

    Science.gov (United States)

    Cwik, T.; Chen, J. C.

    1991-01-01

    The design and predicted performance is described of the microwave layout for three band operation of the beam waveguide antenna Deep Space Station 13. Three pedestal room microwave candidate layout designs were produced for simultaneous X/S and X/Ka band operation. One of the three designs was chosen based on given constraints, and for this design the microwave performance was estimated.

  18. Agriculture Education. Elements of Farm and Building Layout.

    Science.gov (United States)

    Stuttgart Public Schools, AR.

    This curriculum guide is designed for group instruction of secondary agricultural education students enrolled in one or two semester-long courses in elements of farm and building layout. The guide presents units of study in the following areas: (1) sketching and drawing equipment, (2) gothic lettering, (3) layout of a standard sheet, (4) job…

  19. Target aligned heliostat field layout for non-flat terrrain

    CSIR Research Space (South Africa)

    Buck, R

    2012-05-01

    Full Text Available The layout for a solar tower test facility for CSIR, Pretoria, is described. The solar tower system is designed for 400kWth receiver outlet power. The heliostat field layout takes into account both the real (non-flat) topography of the terrain...

  20. Multipurpose layout drawing of metalware of bridge crane load trolley

    Directory of Open Access Journals (Sweden)

    Goncharov K.A.

    2017-03-01

    Full Text Available Multipurpose layout drawing of metalware of bridge crane load trolley is proposed. The numerical analysis of proposed layout drawing is conducted using the example of bridge crane load trolley with capacity of 20 t. This analysis is carried out using the finite element method.

  1. Multipurpose layout drawing of metalware of bridge crane load trolley

    OpenAIRE

    Goncharov K.A.; Denisov I.A.

    2017-01-01

    Multipurpose layout drawing of metalware of bridge crane load trolley is proposed. The numerical analysis of proposed layout drawing is conducted using the example of bridge crane load trolley with capacity of 20 t. This analysis is carried out using the finite element method.

  2. Optimal Control Surface Layout for an Aeroservoelastic Wingbox

    Science.gov (United States)

    Stanford, Bret K.

    2017-01-01

    This paper demonstrates a technique for locating the optimal control surface layout of an aeroservoelastic Common Research Model wingbox, in the context of maneuver load alleviation and active utter suppression. The combinatorial actuator layout design is solved using ideas borrowed from topology optimization, where the effectiveness of a given control surface is tied to a layout design variable, which varies from zero (the actuator is removed) to one (the actuator is retained). These layout design variables are optimized concurrently with a large number of structural wingbox sizing variables and control surface actuation variables, in order to minimize the sum of structural weight and actuator weight. Results are presented that demonstrate interdependencies between structural sizing patterns and optimal control surface layouts, for both static and dynamic aeroelastic physics.

  3. On the impact of layout quality to understanding UML diagrams

    DEFF Research Database (Denmark)

    Störrle, Harald

    2011-01-01

    Practical experience suggests that use and understanding of UML diagrams is greatly affected by the quality of their layout. However, existing experimental evidence for this effect is been weak and inconclusive. In this paper, we explore two explanations. Firstly, we observe that the visual...... qualities of diagrams are more prominent in earlier life cycle phases so that the impact of layout quality should be more apparent in models and diagram types used there, an aspect not studied in previous research. Secondly, in practice, good layouts use many different heuristics simultaneously whereas...... previous research considered them in isolation only. In this paper, we report the results of a series of controlled experiments using compound layouts on requirements analysis models. With very high significance, we find a notable impact of the layout quality measured by different aspects of cognitive load....

  4. Topology-optimized metasurfaces: impact of initial geometric layout.

    Science.gov (United States)

    Yang, Jianji; Fan, Jonathan A

    2017-08-15

    Topology optimization is a powerful iterative inverse design technique in metasurface engineering and can transform an initial layout into a high-performance device. With this method, devices are optimized within a local design phase space, making the identification of suitable initial geometries essential. In this Letter, we examine the impact of initial geometric layout on the performance of large-angle (75 deg) topology-optimized metagrating deflectors. We find that when conventional metasurface designs based on dielectric nanoposts are used as initial layouts for topology optimization, the final devices have efficiencies around 65%. In contrast, when random initial layouts are used, the final devices have ultra-high efficiencies that can reach 94%. Our numerical experiments suggest that device topologies based on conventional metasurface designs may not be suitable to produce ultra-high-efficiency, large-angle metasurfaces. Rather, initial geometric layouts with non-trivial topologies and shapes are required.

  5. 75 FR 56597 - University of Wisconsin; University of Wisconsin Nuclear Reactor Environmental Assessment and...

    Science.gov (United States)

    2010-09-16

    ... when solid waste is generated from use of the UWNR, it is transferred to the University of Wisconsin.... In the years that solid waste was generated, less than 400 milliCuries of solid waste was transferred...; University of Wisconsin Nuclear Reactor Environmental Assessment and Finding of No Significant Impact The U.S...

  6. Rehabilitation of Delavan Lake, Wisconsin

    Science.gov (United States)

    Robertson, Dale M.; Goddard, Gerald L.; Helsel, D.R.; MacKinnon, Kevin L.

    2009-01-01

    A comprehensive rehabilitation plan was developed and implemented to shift Delavan Lake, Wisconsin, from a hypereutrophic to a mesotrophic condition. The plan was threefold: (1) reduce external phosphorus (P) loading by applying Best Management Practices in the watershed, enhance an existing wetland, and short-circuit the inflows through the lake, (2) reduce internal P loading by treating the sediments with alum and removing carp, and (3) rehabilitate the fishery by removing carp and bigmouth buffalo and adding piscivores (biomanipulation). The first and second parts of the plan met with only limited success. With only minor reductions in internal and external P loading, P concentrations in the lake returned to near pre-treatment concentrations. The intensive biomanipulation and resulting trophic cascade (increased piscivores, decreased planktivores, increased large zooplankton populations, and reduced phytoplankton populations) eliminated most of the original problems in the lake (blue-green algal blooms and limited water clarity). However, now there is extensive macrophyte growth and abundant filamentous algae. Without significantly reducing the sources of the problems (high P loading) in Delavan Lake, the increased water clarity may not last. With an improved understanding of the individual components of this rehabilitation program, better future management plans can be developed for Delavan Lake and other lakes and reservoirs with similar eutrophication problems.

  7. Loss of plastoglobule kinases ABC1K1 and ABC1K3 causes conditional degreening, modified prenyl-lipids, and recruitment of the jasmonic acid pathway

    Science.gov (United States)

    Plastoglobules (PGs) are plastid lipid-protein particles. This study examines the function of PG-localized kinases ABC1K1 and ABC1K3 in Arabidopsis thaliana. Several lines of evidence suggested that ABC1K1 and ABC1K3 form a protein complex. Null mutants for both genes (abc1k1 and abc1k3) and the dou...

  8. A generic algorithm for layout of biological networks.

    Science.gov (United States)

    Schreiber, Falk; Dwyer, Tim; Marriott, Kim; Wybrow, Michael

    2009-11-12

    Biological networks are widely used to represent processes in biological systems and to capture interactions and dependencies between biological entities. Their size and complexity is steadily increasing due to the ongoing growth of knowledge in the life sciences. To aid understanding of biological networks several algorithms for laying out and graphically representing networks and network analysis results have been developed. However, current algorithms are specialized to particular layout styles and therefore different algorithms are required for each kind of network and/or style of layout. This increases implementation effort and means that new algorithms must be developed for new layout styles. Furthermore, additional effort is necessary to compose different layout conventions in the same diagram. Also the user cannot usually customize the placement of nodes to tailor the layout to their particular need or task and there is little support for interactive network exploration. We present a novel algorithm to visualize different biological networks and network analysis results in meaningful ways depending on network types and analysis outcome. Our method is based on constrained graph layout and we demonstrate how it can handle the drawing conventions used in biological networks. The presented algorithm offers the ability to produce many of the fundamental popular drawing styles while allowing the exibility of constraints to further tailor these layouts.

  9. A generic algorithm for layout of biological networks

    Directory of Open Access Journals (Sweden)

    Dwyer Tim

    2009-11-01

    Full Text Available Abstract Background Biological networks are widely used to represent processes in biological systems and to capture interactions and dependencies between biological entities. Their size and complexity is steadily increasing due to the ongoing growth of knowledge in the life sciences. To aid understanding of biological networks several algorithms for laying out and graphically representing networks and network analysis results have been developed. However, current algorithms are specialized to particular layout styles and therefore different algorithms are required for each kind of network and/or style of layout. This increases implementation effort and means that new algorithms must be developed for new layout styles. Furthermore, additional effort is necessary to compose different layout conventions in the same diagram. Also the user cannot usually customize the placement of nodes to tailor the layout to their particular need or task and there is little support for interactive network exploration. Results We present a novel algorithm to visualize different biological networks and network analysis results in meaningful ways depending on network types and analysis outcome. Our method is based on constrained graph layout and we demonstrate how it can handle the drawing conventions used in biological networks. Conclusion The presented algorithm offers the ability to produce many of the fundamental popular drawing styles while allowing the exibility of constraints to further tailor these layouts.

  10. Tickborne Powassan virus infections among Wisconsin residents.

    Science.gov (United States)

    Johnson, Diep K Hoang; Staples, J Erin; Sotir, Mark J; Warshauer, David M; Davis, Jeffrey P

    2010-04-01

    Powassan virus (POWV) is a tickborne Flavivirus that causes a rare but potentially life-threatening illness. The first reported case of POWV infection in a Wisconsin resident occurred in 2003. Enhanced surveillance and testing detected 2 additional cases. Patient specimens with a positive or equivocal immunoglobulin M (IgM) antibody to an arbovirus were sent from commercial laboratories to the Wisconsin State Laboratory of Hygiene and forwarded to the Centers for Disease Control and Prevention (CDC) for confirmatory testing. Patients with laboratory confirmed POWV infections were interviewed to obtain demographic, clinical, and epidemiologic information. POWV infections were confirmed in 3 adult Wisconsin residents in 2003, 2006, and 2007; illness onsets occurred during May and June. Two patients were hospitalized and all survived. One patient had a dual infection with POWV and Anaplasma phaghocytophilum. Specimens from all 3 patients were initially reported as positive for IgM antibody to either St Louis encephalitis or California serogroup viruses; POWV-specific antibody was detected during confirmatory testing at the CDC. Each patient had exposures to known or likely tick habitats in different counties within 30 days before illness onset. These are the first diagnosed human POWV infections in Wisconsin. Because all 3 patients were initially identified as having other arboviral infections using commercial screening kits, routine confirmatory testing is essential for proper diagnosis of most arboviral infections. Wisconsin residents should be educated regarding risks of acquiring and ways to prevent POWV infection and other tickborne diseases when spending time outdoors.

  11. Fast grid layout algorithm for biological networks with sweep calculation.

    Science.gov (United States)

    Kojima, Kaname; Nagasaki, Masao; Miyano, Satoru

    2008-06-15

    Properly drawn biological networks are of great help in the comprehension of their characteristics. The quality of the layouts for retrieved biological networks is critical for pathway databases. However, since it is unrealistic to manually draw biological networks for every retrieval, automatic drawing algorithms are essential. Grid layout algorithms handle various biological properties such as aligning vertices having the same attributes and complicated positional constraints according to their subcellular localizations; thus, they succeed in providing biologically comprehensible layouts. However, existing grid layout algorithms are not suitable for real-time drawing, which is one of requisites for applications to pathway databases, due to their high-computational cost. In addition, they do not consider edge directions and their resulting layouts lack traceability for biochemical reactions and gene regulations, which are the most important features in biological networks. We devise a new calculation method termed sweep calculation and reduce the time complexity of the current grid layout algorithms through its encoding and decoding processes. We conduct practical experiments by using 95 pathway models of various sizes from TRANSPATH and show that our new grid layout algorithm is much faster than existing grid layout algorithms. For the cost function, we introduce a new component that penalizes undesirable edge directions to avoid the lack of traceability in pathways due to the differences in direction between in-edges and out-edges of each vertex. Java implementations of our layout algorithms are available in Cell Illustrator. masao@ims.u-tokyo.ac.jp Supplementary data are available at Bioinformatics online.

  12. Optimization of offshore wind farm layout in restricted zones

    DEFF Research Database (Denmark)

    Hou, Peng; Hu, Weihao; Chen, Cong

    2016-01-01

    In this research, an optimization method for offshore wind farm layout design is proposed. With the purpose of maximizing the energy production of the wind farm, the wind turbine (WT) positions are optimized. Due to the limitations of seabed conditions, marine traffic limitations or shipwrecks, etc...... with multiple adaptive methods (PSO-MAM) is adopted. The simulation results indicate that the proposed method can find a layout which outperforms a baseline layout of a reference wind farm (RWF) by increasing the energy yield by 3.84%....

  13. Neighboring Structure Visualization on a Grid-based Layout.

    Science.gov (United States)

    Marcou, G; Horvath, D; Varnek, A

    2017-10-01

    Here, we describe an algorithm to visualize chemical structures on a grid-based layout in such a way that similar structures are neighboring. It is based on structure reordering with the help of the Hilbert Schmidt Independence Criterion, representing an empirical estimate of the Hilbert-Schmidt norm of the cross-covariance operator. The method can be applied to any layout of bi- or three-dimensional shape. The approach is demonstrated on a set of dopamine D5 ligands visualized on squared, disk and spherical layouts. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Implementing high-speed rail in Wisconsin peer exchange.

    Science.gov (United States)

    2009-01-01

    The Wisconsin Department of Transportation Division of Transportation Investment Management hosted : a peer exchange on June 2 -4, 2009 in Milwaukee, Wisconsin. Representatives from four state DOTs and : two freight railroads joined representatives f...

  15. Quantitative comparison between two geometrical layouts for diffraction enhanced imaging

    Energy Technology Data Exchange (ETDEWEB)

    Huang Wanxia; Yuan Qingxi [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China); Zhu Peiping [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China)], E-mail: zhupp@ihep.ac.cn; Wang Junyue; Shu Hang [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China); Chen Bo [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China); Department of Physics, University of Science and Technology of China, Hefei (China); Hu Tiandou [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China); Wu Ziyu [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS, Beijing (China)], E-mail: wuzy@ihep.ac.cn

    2007-07-15

    Diffraction enhanced imaging (DEI) with two crystals has been performed at the 4W1A beamline at Beijing Synchrotron Radiation Facility (BSRF). Two different crystal geometrical layouts were used to collect images, in the first layout the rotation axis of the crystal has been set perpendicular to the orbital plane while in the second the axis is parallel to the orbital plane. Performance comparison between the two layouts is discussed in terms of thermal expansion of the crystal induced by the heat load, imaging homogeneity, spatial resolution and angular resolution. From both experimental and theoretical data we show that the best images may be obtained with the optical layout in which the rotation axis of the crystals is perpendicular to the orbital plane.

  16. Factors driving the spatial layout of distribution channels

    NARCIS (Netherlands)

    Onstein, A.T.C.; Ektesaby, M.; Rezaei, J.; Tavasszy, L.A.; van Damme, D.A.

    2017-01-01

    Research statement Our study analyses the factors that drive decision-making on distribution structures, including the layout of distribution channels and the locations of distribution centres. Distribution is a primary firm activity, which strongly influences logistics costs and logistics

  17. Optimal Material Layout - Applied on Reinforced Concrete Slabs

    DEFF Research Database (Denmark)

    Dollerup, Niels; Jepsen, Michael S.; Damkilde, Lars

    2015-01-01

    This paper introduces a general, finite-element-based optimisation tool for improving the material layout of concrete structures. The application presented is general and exemplified by material optimisation of reinforced concrete slabs. By utilising the optimisation tool, it is possible to deter......This paper introduces a general, finite-element-based optimisation tool for improving the material layout of concrete structures. The application presented is general and exemplified by material optimisation of reinforced concrete slabs. By utilising the optimisation tool, it is possible...... to determine the optimal material layout of a slab in the ultimate load state, based on simple inputs such as outer geometry, boundary conditions, multiple load cases and design domains. The material layout of the optimal design can either be fully orthotropic or isotropic, or a combination with a predefined...

  18. Quantitative comparison between two geometrical layouts for diffraction enhanced imaging

    International Nuclear Information System (INIS)

    Huang Wanxia; Yuan Qingxi; Zhu Peiping; Wang Junyue; Shu Hang; Chen Bo; Hu Tiandou; Wu Ziyu

    2007-01-01

    Diffraction enhanced imaging (DEI) with two crystals has been performed at the 4W1A beamline at Beijing Synchrotron Radiation Facility (BSRF). Two different crystal geometrical layouts were used to collect images, in the first layout the rotation axis of the crystal has been set perpendicular to the orbital plane while in the second the axis is parallel to the orbital plane. Performance comparison between the two layouts is discussed in terms of thermal expansion of the crystal induced by the heat load, imaging homogeneity, spatial resolution and angular resolution. From both experimental and theoretical data we show that the best images may be obtained with the optical layout in which the rotation axis of the crystals is perpendicular to the orbital plane

  19. Evaluation of facility layout alternatives for a remanufacturing environment

    Science.gov (United States)

    Noble, James S.; Lim, Huay-Huay

    2002-02-01

    Remanufacturing environments involve a higher degree of system complexity when compared to traditional manufacturing environments due to the variability associated with the routing, processing times and demand. Many of the consequences of this system complexity can be dealt with through operational-based approaches using specialized production planning and control techniques. However, it is also possible to improve overall system performance through the analysis of appropriate structural issues such as facility layout. This paper presents the results of a simulation-based analysis of four different layout alternatives: traditional job shop, cellular, fractal and holonic. An analysis of each layout alternative is conducted while varying product complexity, dispatching rules, number of workcenters, number of part types, shop load and demand variability with respect to flow time, WIP and machine utilization. The results of the analysis reveal under which conditions each layout alternative would be preferred to achieve the best overall system performance.

  20. Learning Layouts for Single-Page Graphic Designs.

    Science.gov (United States)

    O'Donovan, Peter; Agarwala, Aseem; Hertzmann, Aaron

    2014-08-01

    This paper presents an approach for automatically creating graphic design layouts using a new energy-based model derived from design principles. The model includes several new algorithms for analyzing graphic designs, including the prediction of perceived importance, alignment detection, and hierarchical segmentation. Given the model, we use optimization to synthesize new layouts for a variety of single-page graphic designs. Model parameters are learned with Nonlinear Inverse Optimization (NIO) from a small number of example layouts. To demonstrate our approach, we show results for applications including generating design layouts in various styles, retargeting designs to new sizes, and improving existing designs. We also compare our automatic results with designs created using crowdsourcing and show that our approach performs slightly better than novice designers.

  1. Influence of offshore wind farms layout on electrical resonances

    DEFF Research Database (Denmark)

    Holdyk, Andrzej; Holbøll, Joachim; Koldby, Erik

    2014-01-01

    , winding resistances and winding capacitances. Considering the frequency range of the present investigations, up to about 1 MHz, a lumped representation of the transformer characteristics was deemed sufficient. Breakers and capacitors are modelled as ideal components. The chosen wind farm layout includes...... ranges. The results show the influence of specific parameters being varied depending on the farm layout. In particular, cable lengths and transformer broad band characteristics turned out to have significant impact on the results....

  2. KBS-3H layout adaptation 2007 for the Olkiluoto site

    International Nuclear Information System (INIS)

    Johansson, Erik; Hagros, Annika; Autio, Jorma; Kirkkomaeki, Timo

    2008-05-01

    As part of the KBS-3H design an Olkiluoto-specific layout of a KBS-3H repository has been produced based on the latest Olkiluoto data and the bedrock model. One of the main goals of this work was to support the evaluation of the feasibility of the one layer KBS-3H concept and to compare the layouts based on the KBS-3H and KBS-3V disposal concepts. The layout presented in this work can be considered only preliminary and involves a number of uncertainties. The percentage of unusable host rock was assumed to be 25% in this work but can change due to the further design of the different components of the KBS-3H disposal system and further development of the host rock criteria. The layout is also significantly affected by the layout-determining fracture zones. In this work 11 major (highly transmissive) fracture zones interpreted to intersect the -420 m level were considered deterministically. The KBS-3H layout requires a larger area than the KBS-3V repository and takes up most of the available area between the major fracture zones HZ20 and HZ21. This is mainly due to the long drift sections occupied by the compartment plugs (30 m) and the bentonite blocks in the blank zones (10 m), which reduces the usability of the host rock and results in larger canister spacings than in the KBS-3V concept, where the positioning of the deposition holes is very flexible and narrow zones with a moderate transmissivity usually have only a minor effect on the locations of the canisters. According to the results, there is enough bedrock in the current investigation area at central Olkiluoto for KBS-3H layout in one layer. However the layout takes up nearly all of the potential bedrock resource and therefore the result is quite sensitive to possible changes in the design bases

  3. Site selection and general layout of heap leaching uranium mill

    International Nuclear Information System (INIS)

    Zhang Chunmao; Rongfeng

    2011-01-01

    The site selection and general layout of uranium mill is an important work in the design and consultation stage of uranium mining and metallurgy's engineering construction. Based on the design practices, the principles and methods for the site selection and general layout of heap leaching uranium mill are analyzed and studied. Some problems which should be paid much attention to in the design are discussed in hopes of providing a useful reference for the design and consultation of similar projects. (authors)

  4. Plant ABC proteins--a unified nomenclature and updated inventory.

    Science.gov (United States)

    Verrier, Paul J; Bird, David; Burla, Bo; Dassa, Elie; Forestier, Cyrille; Geisler, Markus; Klein, Markus; Kolukisaoglu, Uner; Lee, Youngsook; Martinoia, Enrico; Murphy, Angus; Rea, Philip A; Samuels, Lacey; Schulz, Burkhard; Spalding, Edgar J; Yazaki, Kazufumi; Theodoulou, Frederica L

    2008-04-01

    The ABC superfamily comprises both membrane-bound transporters and soluble proteins involved in a broad range of processes, many of which are of considerable agricultural, biotechnological and medical potential. Completion of the Arabidopsis and rice genome sequences has revealed a particularly large and diverse complement of plant ABC proteins in comparison with other organisms. Forward and reverse genetics, together with heterologous expression, have uncovered many novel roles for plant ABC proteins, but this progress has been accompanied by a confusing proliferation of names for plant ABC genes and their products. A consolidated nomenclature will provide much-needed clarity and a framework for future research.

  5. Layout dependent effects analysis on 28nm process

    Science.gov (United States)

    Li, Helen; Zhang, Mealie; Wong, Waisum; Song, Huiyuan; Xu, Wei; Hurat, Philippe; Ding, Hua; Zhang, Yifan; Cote, Michel; Huang, Jason; Lai, Ya-ch

    2015-03-01

    Advanced process nodes introduce new variability effects due to increased density, new material, new device structures, and so forth. This creates more and stronger Layout Dependent effects (LDE), especially below 28nm. These effects such as WPE (Well Proximity Effect), PSE (Poly Spacing Effect) change the carrier mobility and threshold voltage and therefore make the device performances, such as Vth and Idsat, extremely layout dependent. In traditional flows, the impact of these changes can only be simulated after the block has been fully laid out, the design is LVS and DRC clean. It's too late in the design cycle and it increases the number of post-layout iteration. We collaborated to develop a method on an advanced process to embed several LDE sources into a LDE kit. We integrated this LDE kit in custom analog design environment, for LDE analysis at early design stage. These features allow circuit and layout designers to detect the variations caused by LDE, and to fix the weak points caused by LDE. In this paper, we will present this method and how it accelerates design convergence of advanced node custom analog designs by detecting early-on LDE hotspots on partial or fully placed layout, reporting contribution of each LDE component to help identify the root cause of LDE variation, and even providing fixing guidelines on how to modify the layout and to reduce the LDE impact.

  6. Global scene layout modulates contextual learning in change detection.

    Science.gov (United States)

    Conci, Markus; Müller, Hermann J

    2014-01-01

    Change in the visual scene often goes unnoticed - a phenomenon referred to as "change blindness." This study examined whether the hierarchical structure, i.e., the global-local layout of a scene can influence performance in a one-shot change detection paradigm. To this end, natural scenes of a laid breakfast table were presented, and observers were asked to locate the onset of a new local object. Importantly, the global structure of the scene was manipulated by varying the relations among objects in the scene layouts. The very same items were either presented as global-congruent (typical) layouts or as global-incongruent (random) arrangements. Change blindness was less severe for congruent than for incongruent displays, and this congruency benefit increased with the duration of the experiment. These findings show that global layouts are learned, supporting detection of local changes with enhanced efficiency. However, performance was not affected by scene congruency in a subsequent control experiment that required observers to localize a static discontinuity (i.e., an object that was missing from the repeated layouts). Our results thus show that learning of the global layout is particularly linked to the local objects. Taken together, our results reveal an effect of "global precedence" in natural scenes. We suggest that relational properties within the hierarchy of a natural scene are governed, in particular, by global image analysis, reducing change blindness for local objects through scene learning.

  7. Estimating perception of scene layout properties from global image features.

    Science.gov (United States)

    Ross, Michael G; Oliva, Aude

    2010-01-08

    The relationship between image features and scene structure is central to the study of human visual perception and computer vision, but many of the specifics of real-world layout perception remain unknown. We do not know which image features are relevant to perceiving layout properties, or whether those features provide the same information for every type of image. Furthermore, we do not know the spatial resolutions required for perceiving different properties. This paper describes an experiment and a computational model that provides new insights on these issues. Humans perceive the global spatial layout properties such as dominant depth, openness, and perspective, from a single image. This work describes an algorithm that reliably predicts human layout judgments. This model's predictions are general, not specific to the observers it trained on. Analysis reveals that the optimal spatial resolutions for determining layout vary with the content of the space and the property being estimated. Openness is best estimated at high resolution, depth is best estimated at medium resolution, and perspective is best estimated at low resolution. Given the reliability and simplicity of estimating the global layout of real-world environments, this model could help resolve perceptual ambiguities encountered by more detailed scene reconstruction schemas.

  8. Scalable force directed graph layout algorithms using fast multipole methods

    KAUST Repository

    Yunis, Enas Abdulrahman

    2012-06-01

    We present an extension to ExaFMM, a Fast Multipole Method library, as a generalized approach for fast and scalable execution of the Force-Directed Graph Layout algorithm. The Force-Directed Graph Layout algorithm is a physics-based approach to graph layout that treats the vertices V as repelling charged particles with the edges E connecting them acting as springs. Traditionally, the amount of work required in applying the Force-Directed Graph Layout algorithm is O(|V|2 + |E|) using direct calculations and O(|V| log |V| + |E|) using truncation, filtering, and/or multi-level techniques. Correct application of the Fast Multipole Method allows us to maintain a lower complexity of O(|V| + |E|) while regaining most of the precision lost in other techniques. Solving layout problems for truly large graphs with millions of vertices still requires a scalable algorithm and implementation. We have been able to leverage the scalability and architectural adaptability of the ExaFMM library to create a Force-Directed Graph Layout implementation that runs efficiently on distributed multicore and multi-GPU architectures. © 2012 IEEE.

  9. The role of the atypical kinases ABC1K7 and ABC1K8 in abscisic acid responses

    Directory of Open Access Journals (Sweden)

    Anna eManara

    2016-03-01

    Full Text Available The ABC1K family of atypical kinases (activity of bc1 complex kinase is represented in bacteria, archaea and eukaryotes. In plants they regulate diverse physiological processes in the chloroplasts and mitochondria, but their precise functions are poorly defined. ABC1K7 and ABC1K8 are probably involved in oxidative stress responses, isoprenyl lipid synthesis and distribution of iron within chloroplasts. Because reactive oxygen species take part in abscisic acid (ABA-mediated processes, we investigated the functions of ABC1K7 and ABC1K8 during germination, stomatal movement and leaf senescence. Both genes were upregulated by ABA treatment and some ABA-responsive physiological processes were affected in abc1k7 and abc1k8 mutants. Germination was more severely affected by ABA, osmotic stress and salt stress in the single and double mutants; the stomatal aperture was smaller in the mutants under standard growth conditions and was not further reduced by exogenous ABA application; ABA-induced senescence symptoms were more severe in the leaves of the single and double mutants compared to wild type leaves. Taken together, our results suggest that ABC1K7 and ABC1K8 might be involved in the cross-talk between ABA and ROS signaling.

  10. The Legal Status of Homemakers in Wisconsin.

    Science.gov (United States)

    Melli, Marygold Shire

    This report focuses on laws in the state of Wisconsin as they relate to homemakers. Four areas are discussed, each in separate sections: marriage, widowhood, divorce, and wife abuse. The section on marriage includes information on property rights, disability and death of homemaker, federal Equal Credit Opportunity Act, domicile, interspousal…

  11. Divided Wisconsin: Partisan Spatial Electoral Realignment

    Science.gov (United States)

    Zaniewski, Kazimierz J.; Simmons, James R.

    2016-01-01

    When the Republican and Democratic presidential candidates head into the general election this fall, they will be courting votes from a statewide electorate that has dramatically shifted over time, mirroring the political polarization that is happening across the country. Over the last three decades, Wisconsin's political geography has evolved…

  12. Wisconsin Public Schools at a Glance, 2016

    Science.gov (United States)

    Wisconsin Department of Public Instruction, 2016

    2016-01-01

    "Wisconsin Public Schools at a Glance" provides in a single page document statistical information on the following topics: (1) Total number of public schools (2015-16); (2) Student (2015-16); (3) Attendance & Graduation (2014-15);(4) Staff (2013-14); (5) School Funding; and (6) Student Performance (2014-15). [For the previous report…

  13. Wisconsin Public Schools at a Glance

    Science.gov (United States)

    Wisconsin Department of Public Instruction, 2014

    2014-01-01

    "Wisconsin Public Schools at a Glance" provides in a single page document statistical information on the following topics: (1) Total number of public schools (2014-15); (2) Staff (2013-14); (3) Students (2013-14);(4) Report Cards (2013-14); (5) Attendance and Graduation (2012-13); (6) Student Performance (2013-14); and (7) School Funding.

  14. The University of Wisconsin OAO operating system

    Science.gov (United States)

    Heacox, H. C.; Mcnall, J. F.

    1972-01-01

    The Wisconsin OAO operating system is presented which consists of two parts: a computer program called HARUSPEX, which makes possible reasonably efficient and convenient operation of the package and ground operations equipment which provides real-time status monitoring, commanding and a quick-look at the data.

  15. Genetic Analysis of Termite Colonies in Wisconsin

    Science.gov (United States)

    R.A. Arango; D.A. Marschalek; F. Green III; K.F. Raffa; M.E. Berres

    2015-01-01

    The objective of this study was to document current areas of subterranean termite activity in Wisconsin and to evaluate genetic characteristics of these northern, peripheral colonies. Here, amplified fragment-length polymorphism was used to characterize levels of inbreeding, expected heterozygosity, and percent polymorphism within colonies as well as genetic structure...

  16. Stakeholders' Perceptions of Parcelization in Wisconsin's Northwoods

    Science.gov (United States)

    Mark G. Rickenbach; Paul H. Gobster

    2003-01-01

    Parcelization, the process by which relatively large forest ownerships become subdivided into smaller ones, is often related to changes in ownership and can bring changes to the use of the land. Landowners, resource professionals, and others interested in Wisconsin's Northwoods were asked their views on parcelization in a series of stakeholder forums. We analyzed...

  17. Sorghum as a forage in Wisconsin

    Science.gov (United States)

    Growing moderate quality forages that meet, but do not exceed, requirements of dairy replacement heifers is not a common practice in Wisconsin; however, this forage management option would have a positive impact on the dairy industry. It is typical for heifers to gain excessive bodyweight when they ...

  18. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  19. Nonlinear resonances in the ABC-flow

    Science.gov (United States)

    Didov, A. A.; Uleysky, M. Yu.

    2018-01-01

    In this paper, we study resonances of the ABC-flow in the near integrable case ( C ≪1 ). This is an interesting example of a Hamiltonian system with 3/2 degrees of freedom in which simultaneous existence of two resonances of the same order is possible. Analytical conditions of the resonance existence are received. It is shown numerically that the largest n :1 (n = 1, 2, 3) resonances exist, and their energies are equal to theoretical energies in the near integrable case. We provide analytical and numerical evidences for existence of two branches of the two largest n :1 (n = 1, 2) resonances in the region of finite motion.

  20. SIMPLIFIED MATHEMATICAL MODEL OF SMALL SIZED UNMANNED AIRCRAFT VEHICLE LAYOUT

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available Strong reduction of new aircraft design period using new technology based on artificial intelligence is the key problem mentioned in forecasts of leading aerospace industry research centers. This article covers the approach to devel- opment of quick aerodynamic design methods based on artificial intelligence neural system. The problem is being solved for the classical scheme of small sized unmanned aircraft vehicle (UAV. The principal parts of the method are the mathe- matical model of layout, layout generator of this type of aircraft is built on aircraft neural networks, automatic selection module for cleaning variety of layouts generated in automatic mode, robust direct computational fluid dynamics method, aerodynamic characteristics approximators on artificial neural networks.Methods based on artificial neural networks have intermediate position between computational fluid dynamics methods or experiments and simplified engineering approaches. The use of ANN for estimating aerodynamic characteris-tics put limitations on input data. For this task the layout must be presented as a vector with dimension not exceeding sev-eral hundred. Vector components must include all main parameters conventionally used for layouts description and com- pletely replicate the most important aerodynamics and structural properties.The first stage of the work is presented in the paper. Simplified mathematical model of small sized UAV was developed. To estimate the range of geometrical parameters of layouts the review of existing vehicle was done. The result of the work is the algorithm and computer software for generating the layouts based on ANN technolo-gy. 10000 samples were generated and the dataset containig geometrical and aerodynamic characteristics of layoutwas created.

  1. Preliminary Design Through Graphs: A Tool for Automatic Layout Distribution

    Directory of Open Access Journals (Sweden)

    Carlo Biagini

    2015-02-01

    Full Text Available Diagrams are essential in the preliminary stages of design for understanding distributive aspects and assisting the decision-making process. By drawing a schematic graph, designers can visualize in a synthetic way the relationships between many aspects: functions and spaces, distribution of layouts, space adjacency, influence of traffic flows within a facility layout, and so on. This process can be automated through the use of modern Information and Communication Technologies tools (ICT that allow the designers to manage a large quantity of information. The work that we will present is part of an on-going research project into how modern parametric software influences decision-making on the basis of automatic and optimized layout distribution. The method involves two phases: the first aims to define the ontological relation between spaces, with particular reference to a specific building typology (rules of aggregation of spaces; the second entails the implementation of these rules through the use of specialist software. The generation of ontological relations begins with the collection of data from historical manuals and analyses of case studies. These analyses aim to generate a “relationship matrix” based on preferences of space adjacency. The phase of implementing the previously defined rules is based on the use of Grasshopper to analyse and visualize different layout configurations. The layout is generated by simulating a process involving the collision of spheres, which represents specific functions of the design program. The spheres are attracted or rejected as a function of the relationships matrix, as defined above. The layout thus obtained will remain in a sort of abstract state independent of information about the exterior form, but will still provide a useful tool for the decision-making process. In addition, preliminary results gathered through the analysis of case studies will be presented. These results provide a good variety

  2. An efficient biological pathway layout algorithm combining grid-layout and spring embedder for complicated cellular location information.

    Science.gov (United States)

    Kojima, Kaname; Nagasaki, Masao; Miyano, Satoru

    2010-06-18

    Graph drawing is one of the important techniques for understanding biological regulations in a cell or among cells at the pathway level. Among many available layout algorithms, the spring embedder algorithm is widely used not only for pathway drawing but also for circuit placement and www visualization and so on because of the harmonized appearance of its results. For pathway drawing, location information is essential for its comprehension. However, complex shapes need to be taken into account when torus-shaped location information such as nuclear inner membrane, nuclear outer membrane, and plasma membrane is considered. Unfortunately, the spring embedder algorithm cannot easily handle such information. In addition, crossings between edges and nodes are usually not considered explicitly. We proposed a new grid-layout algorithm based on the spring embedder algorithm that can handle location information and provide layouts with harmonized appearance. In grid-layout algorithms, the mapping of nodes to grid points that minimizes a cost function is searched. By imposing positional constraints on grid points, location information including complex shapes can be easily considered. Our layout algorithm includes the spring embedder cost as a component of the cost function. We further extend the layout algorithm to enable dynamic update of the positions and sizes of compartments at each step. The new spring embedder-based grid-layout algorithm and a spring embedder algorithm are applied to three biological pathways; endothelial cell model, Fas-induced apoptosis model, and C. elegans cell fate simulation model. From the positional constraints, all the results of our algorithm satisfy location information, and hence, more comprehensible layouts are obtained as compared to the spring embedder algorithm. From the comparison of the number of crossings, the results of the grid-layout-based algorithm tend to contain more crossings than those of the spring embedder algorithm due to

  3. ABC's "Person of the Week": American Values in Television News.

    Science.gov (United States)

    Larson, Stephanie Greco; Bailey, Martha

    1998-01-01

    Contributes to scholarship on values and ideologies in the media by analyzing five years of ABC's "Person of the Week" segments to identify prominent types of people and values endorsed by mainstream news media. Finds that individuals most frequently selected for ABC's honor lived in the United States; worked in politics and…

  4. Measuring Academic Behavioural Confidence: The ABC Scale Revisited

    Science.gov (United States)

    Sander, Paul; Sanders, Lalage

    2009-01-01

    The Academic Behavioural Confidence (ABC) scale has been shown to be valid and can be useful to teachers in understanding their students, enabling the design of more effective teaching sessions with large cohorts. However, some of the between-group differences have been smaller than expected, leading to the hypothesis that the ABC scale many not…

  5. Dashboard Auditing of Activity-Based Costing (ABC

    Directory of Open Access Journals (Sweden)

    Sorinel Capusneanu

    2009-03-01

    Full Text Available This article aims to define the dashboard auditing according to the specifics of Activity-Based Costing method (ABC. It describes the main objectives of dashboard auditing, the criteria that a dashboard auditor should meet and the step-by-step stages of the entire dashboard auditing process according to the Activity-Based Costing method (ABC.

  6. Dashboard Auditing of Activity-Based Costing (ABC)

    OpenAIRE

    Sorinel Capusneanu

    2009-01-01

    This article aims to define the dashboard auditing according to the specifics of Activity-Based Costing method (ABC). It describes the main objectives of dashboard auditing, the criteria that a dashboard auditor should meet and the step-by-step stages of the entire dashboard auditing process according to the Activity-Based Costing method (ABC).

  7. Dashboard auditing of ABC (Activity-Based Costing). Theoretical approaches

    OpenAIRE

    Căpuşneanu, Sorinel/I

    2009-01-01

    This article aims to define the dashboard auditing according to the specifics of Activity-Based Costing method (ABC). It describes the main objectives of dashboard auditing, the criteria that a dashboard auditor should meet and the step-by-step stages of the entire dashboard auditing process of an enterprise from steel industry according to the Activity-Based Costing method (ABC).

  8. Plant Layout Analysis by Computer Simulation for Electronic Manufacturing Service Plant

    OpenAIRE

    Visuwan D.; Phruksaphanrat B

    2014-01-01

    In this research, computer simulation is used for Electronic Manufacturing Service (EMS) plant layout analysis. The current layout of this manufacturing plant is a process layout, which is not suitable due to the nature of an EMS that has high-volume and high-variety environment. Moreover, quick response and high flexibility are also needed. Then, cellular manufacturing layout design was determined for the selected group of products. Systematic layout planning (SLP) was used to analyze and de...

  9. Sustained Delivery of Chondroitinase ABC from Hydrogel System

    Directory of Open Access Journals (Sweden)

    Filippo Rossi

    2012-03-01

    Full Text Available In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-prone and clinically problematic. An agarose-carbomer (AC1 hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. Subsequently, release kinetic and the maintenance of enzymatic activity were positively assessed: AC1 hydrogel was thus confirmed to be a feasible tool for chABC delivery and a promising device for spinal cord injury topic repair strategies.

  10. PPAR Medicines and Human Disease: The ABCs of It All

    Directory of Open Access Journals (Sweden)

    Anthony J. Apostoli

    2012-01-01

    Full Text Available ATP-dependent binding cassette (ABC transporters are a family of transmembrane proteins that pump a variety of hydrophobic compounds across cellular and subcellular barriers and are implicated in human diseases such as cancer and atherosclerosis. Inhibition of ABC transporter activity showed promise in early preclinical studies; however, the outcomes in clinical trials with these agents have not been as encouraging. Peroxisome proliferator-activated receptors (PPARs are ligand-activated transcription factors that regulate genes involved in fat and glucose metabolism, and inflammation. Activation of PPAR signaling is also reported to regulate ABC gene expression. This suggests the potential of PPAR medicines as a novel means of controlling ABC transporter activity at the transcriptional level. This paper summarizes the advances made in understanding how PPAR medicines affect ABC transporters, and the potential implications for impacting on human diseases, in particular with respect to cancer and atherosclerosis.

  11. Optimization of offshore wind farm layout in restricted zones

    International Nuclear Information System (INIS)

    Hou, Peng; Hu, Weihao; Chen, Cong; Soltani, Mohsen; Chen, Zhe

    2016-01-01

    In this research, an optimization method for offshore wind farm layout design is proposed. With the purpose of maximizing the energy production of the wind farm, the wind turbine (WT) positions are optimized. Due to the limitations of seabed conditions, marine traffic limitations or shipwrecks, etc., the WTs are expected to be placed outside specific areas. Based on this fact, a restriction zone concept is proposed in this paper and implemented with the penalty function method. In order to find a feasible solution, a recent proposed stochastic algorithm, particle swarm optimization algorithm with multiple adaptive methods (PSO-MAM) is adopted. The simulation results indicate that the proposed method can find a layout which outperforms a baseline layout of a reference wind farm (RWF) by increasing the energy yield by 3.84%. - Highlights: • The offshore restricted area concept is proposed. • The recent developed PSO-MAM algorithm is arranged to optimize the layout. • The penalty function method is adopted to help find the feasible solution. • The optimized layout increases energy yields 3.84% than reference wind farm.

  12. A flexible layout design method for passive micromixers.

    Science.gov (United States)

    Deng, Yongbo; Liu, Zhenyu; Zhang, Ping; Liu, Yongshun; Gao, Qingyong; Wu, Yihui

    2012-10-01

    This paper discusses a flexible layout design method of passive micromixers based on the topology optimization of fluidic flows. Being different from the trial and error method, this method obtains the detailed layout of a passive micromixer according to the desired mixing performance by solving a topology optimization problem. Therefore, the dependence on the experience of the designer is weaken, when this method is used to design a passive micromixer with acceptable mixing performance. Several design disciplines for the passive micromixers are considered to demonstrate the flexibility of the layout design method for passive micromixers. These design disciplines include the approximation of the real 3D micromixer, the manufacturing feasibility, the spacial periodic design, and effects of the Péclet number and Reynolds number on the designs obtained by this layout design method. The capability of this design method is validated by several comparisons performed between the obtained layouts and the optimized designs in the recently published literatures, where the values of the mixing measurement is improved up to 40.4% for one cycle of the micromixer.

  13. The Influence of Environmental Spatial Layout on Perceived Lightness

    Science.gov (United States)

    Kanari, Kei; Inagami, Makoto; Kaneko, Hirohiko

    2011-01-01

    It is obvious that perceived lightness of a surface depends on the surrounding luminance distribution in 2D and 3D. These effects are usually explained by the mechanisms at relatively low level of visual system. However, there seems to be a relation between the illuminance and spatial layout of the scene regardless of the surrounding luminance distribution. If this is valid, perceived lightness of a surface in the scene could be influenced by the spatial layout in the scene. In this research, we investigated the relation between the perceived lightness of surface and the spatial layout of the scene. The subject matched the lightness of test patch presented on a natural picture with various spatial layout to that of comparison stimulus presented on a uniform gray background. The mean luminance of the surround stimuli were the same and the local contrast between the text patch and the surround was kept constant. Results showed that the perceived lightness of a stimulus depended on the spatial structure presented in the background. This result indicates that the spatial layout of the scene is related to the illuminance of that and influenced on perceived lightness.

  14. Genetic Algorithm (GA)-Based Inclinometer Layout Optimization.

    Science.gov (United States)

    Liang, Weijie; Zhang, Ping; Chen, Xianping; Cai, Miao; Yang, Daoguo

    2015-04-17

    This paper presents numerical simulation results of an airflow inclinometer with sensitivity studies and thermal optimization of the printed circuit board (PCB) layout for an airflow inclinometer based on a genetic algorithm (GA). Due to the working principle of the gas sensor, the changes of the ambient temperature may cause dramatic voltage drifts of sensors. Therefore, eliminating the influence of the external environment for the airflow is essential for the performance and reliability of an airflow inclinometer. In this paper, the mechanism of an airflow inclinometer and the influence of different ambient temperatures on the sensitivity of the inclinometer will be examined by the ANSYS-FLOTRAN CFD program. The results show that with changes of the ambient temperature on the sensing element, the sensitivity of the airflow inclinometer is inversely proportional to the ambient temperature and decreases when the ambient temperature increases. GA is used to optimize the PCB thermal layout of the inclinometer. The finite-element simulation method (ANSYS) is introduced to simulate and verify the results of our optimal thermal layout, and the results indicate that the optimal PCB layout greatly improves (by more than 50%) the sensitivity of the inclinometer. The study may be useful in the design of PCB layouts that are related to sensitivity improvement of gas sensors.

  15. Layout design in order to improve efficiency in manufacturing

    Science.gov (United States)

    Siregar, I.; Tarigan, U.; Nasution, T. H.

    2018-02-01

    This research was conducted at the company that produces bobbins and ream type cigarette paper. Problems that found on the production process is the back and forth (back tracking) movement. Back and forth (back tracking) movement extending the total distance moved by the material and increase the total moment of transfer materials thus reducing the efficiency of the transfer of materials in the production process. The purpose of this study is to give design for the layout of production facilities in the company, so that the expected production produced by the company can reach the targets set by the management company. The method used in this research is the Graph-Based Construction and Travel Chart Method. The results of the analysis of the proposed layout with Graph-Based Construction was selected with a total value that is equal to the moment of transfer of 780 758 m / year. This result is better than the actual layout in the amount of 1,021,038.12 meters / year and the results of the method Travel Alternative Chart I of 826.236,60 meters/year, Alternative II of 1.004.433,56 meters / year, and Alternative III for 828,467.12 meters/year. The design layout of Graph-Based Construction material increases the transfer efficiency for 23.53%. With this layout proposal, expected production capacity will be increased along with the shortening of the distance of the displacement that must be passed by the material to be processed.

  16. Current advances on ABC drug transporters in fish.

    Science.gov (United States)

    Luckenbach, Till; Fischer, Stephan; Sturm, Armin

    2014-09-01

    Most members of the large ATP-binding cassette (ABC) gene family are transporters involved in substrate translocation across biological membranes. In eukaryotes, ABC proteins functioning as drug transporters are located in the plasma membrane and mediate the cellular efflux of a wide range of organic chemicals, with some transporters also transporting certain metals. As the enhanced expression of ABC drug transporters can confer multidrug resistance (MDR) to cancers and multixenobiotic resistance (MXR) to organisms from polluted habitats, these ABC family members are also referred to as MDR or MXR proteins. In mammals, ABC drug transporters show predominant expression in tissues involved in excretion or constituting internal or external body boundaries, where they facilitate the excretion of chemicals and their metabolites, and limit chemical uptake and penetration into "sanctuary" sites of the body. Available knowledge about ABC proteins is still limited in teleost fish, a large vertebrate group of high ecological and economic importance. Using transport activity measurements and immunochemical approaches, early studies demonstrated similarities in the tissue distribution of ABC drug transporters between teleosts and mammals, suggesting conserved roles of the transporters in the biochemical defence against toxicants. Recently, the availability of teleost genome assemblies has stimulated studies of the ABC family in this taxon. This review summarises the current knowledge regarding the genetics, functional properties, physiological function, and ecotoxicological relevance of teleostean ABC transporters. The available literature is reviewed with emphasis on recent studies addressing the tissue distribution, substrate spectrum, regulation, physiological function and phylogenetic origin of teleostean ABC transporters. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  17. The ABC of ABC : An analysis of attribute-based credentials in the light of data protection, privacy and identity.

    NARCIS (Netherlands)

    Korenhof, P.E.I.; Koning, Merel; Alpár, Gergely; Hoepman, J.H.; Padullés, Joan Balcells; i Martínez, Agustí Cerrillo; Poch, Miquel Peguera; López, Ismael Peña; de Moner, María José Pifarré; Solana, Mònica Vilasau

    2014-01-01

    Our networked society increasingly needs secure identity sys- tems. The Attribute-based credential (ABC) technology is designed to be privacy-friendlier than contemporary authentication methods, which often suffer from information leakage. So far, however, some of the wider implications of ABC have

  18. Analysis of Sequence Diagram Layout in Advanced UML Modelling Tools

    Directory of Open Access Journals (Sweden)

    Ņikiforova Oksana

    2016-05-01

    Full Text Available System modelling using Unified Modelling Language (UML is the task that should be solved for software development. The more complex software becomes the higher requirements are stated to demonstrate the system to be developed, especially in its dynamic aspect, which in UML is offered by a sequence diagram. To solve this task, the main attention is devoted to the graphical presentation of the system, where diagram layout plays the central role in information perception. The UML sequence diagram due to its specific structure is selected for a deeper analysis on the elements’ layout. The authors research represents the abilities of modern UML modelling tools to offer automatic layout of the UML sequence diagram and analyse them according to criteria required for the diagram perception.

  19. Optimization of Wind Farm Layout in Complex Terrain

    DEFF Research Database (Denmark)

    Xu, Chang; Yang, Jianchuan; Li, Chenqi

    2013-01-01

    Microscopic site selection for wind farms in complex terrain is a technological difficulty in the development of onshore wind farms. This paper presented a method for optimizing wind farm layout in complex terrain. This method employed Lissaman and Jensen wake models, took wind velocity distribut......Microscopic site selection for wind farms in complex terrain is a technological difficulty in the development of onshore wind farms. This paper presented a method for optimizing wind farm layout in complex terrain. This method employed Lissaman and Jensen wake models, took wind velocity...... are subject to boundary conditions and minimum distance conditions. The improved genetic algorithm (GA) for real number coding was used to search the optimal result. Then the optimized result was compared to the result from the experienced layout method. Results show the advantages of the present method...

  20. Ergonomics and simulation-based approach in improving facility layout

    Science.gov (United States)

    Abad, Jocelyn D.

    2018-02-01

    The use of the simulation-based technique in facility layout has been a choice in the industry due to its convenience and efficient generation of results. Nevertheless, the solutions generated are not capable of addressing delays due to worker's health and safety which significantly impact overall operational efficiency. It is, therefore, critical to incorporate ergonomics in facility design. In this study, workstation analysis was incorporated into Promodel simulation to improve the facility layout of a garment manufacturing. To test the effectiveness of the method, existing and improved facility designs were measured using comprehensive risk level, efficiency, and productivity. Results indicated that the improved facility layout generated a decrease in comprehensive risk level and rapid upper limb assessment score; an increase of 78% in efficiency and 194% increase in productivity compared to existing design and thus proved that the approach is effective in attaining overall facility design improvement.

  1. Effect of layout on surge line thermal stratification

    International Nuclear Information System (INIS)

    Lai Jianyong; Huang Wei

    2011-01-01

    In order to analyze and evaluate the effect of layout on the thermal stratification for PWR Pressurizer surge line, numerical simulation by Computational Fluid Dynamics (CFD) method is taken on 6 kinds of layout improvement with 2 improvement schemes, i.e., increasing the obliquity of quasi horizontal section and adding a vertical pipe between the quasi horizontal section and next elbow, and the maximum temperature differences of quasi horizontal section of surge line of various layouts under different flowrate are obtained. The comparison shows that, the increasing of the obliquity of quasi horizontal section can mitigate the thermal stratification phenomena but can not eliminate this phenomena, while the adding of a vertical pipe between the quasi horizontal section and next elbow can effectively mitigate and eliminate the thermal stratification phenomena. (authors)

  2. How the global layout of the mask influences masking strength.

    Science.gov (United States)

    Ghose, Tandra; Hermens, Frouke; Herzog, Michael H

    2012-12-10

    In visual backward masking, the perception of a target is influenced by a trailing mask. Masking is usually explained by local interactions between the target and the mask representations. However, recently it has been shown that the global spatial layout of the mask rather than its local structure determines masking strength (Hermens & Herzog, 2007). Here, we varied the mask layout by spatial, luminance, and temporal cues. We presented a vernier target followed by a mask with 25 elements. Performance deteriorated when the length of the two mask elements neighboring the target vernier was doubled. However, when the length of every second mask element was doubled, performance improved. When the luminance of the neighboring elements was doubled, performance also deteriorated but no improvement in performance was observed when every second element had a double luminance. For temporal manipulations, a complex nonmonotonic masking function was observed. Hence, changes in the mask layout by spatial, luminance, and temporal cues lead to highly different results.

  3. Production layout improvement in emergency services: a participatory approach.

    Science.gov (United States)

    Zanatta, Mateus; Amaral, Fernando Gonçalves

    2012-01-01

    Volunteer fire department is a service that responds emergency situations in places where there are no military emergency services. These services need to respond quickly, because time is often responsible for the operation success besides work environment and setup time interfere with the prompt response to these calls and care efficiency. The layout design is one factor that interferes with the quick setup. In this case, the spaces arrangement can result in excessive or unnecessary movements; also the equipment provision may hinder the selection and collection of these or even create movement barriers for the workers. This work created a new layout for the emergency assistance service, considering the human factors related to work through the task analysis and workers participation on the alternatives of improvement. The results showed an alternate layout with corridors and minimization of unusable sites, allowing greater flexibility and new possibilities of requirements.

  4. Optimization of Orchestral Layouts Based on Instrument Directivity Patterns

    Science.gov (United States)

    Stroud, Nathan Paul

    The experience of hearing an exceptional symphony orchestra perform in an excel- lent concert hall can be profound and moving, causing a level of excitement not often reached for listeners. Romantic period style orchestral music, recognized for validating the use of intense emotion for aesthetic pleasure, was the last significant development in the history of the orchestra. In an age where orchestral popularity is waning, the possibil- ity of evolving the orchestral sound in our modern era exists through the combination of our current understanding of instrument directivity patterns and their interaction with architectural acoustics. With the aid of wave field synthesis (WFS), newly proposed variations on orchestral layouts are tested virtually using a 64-channel WFS array. Each layout is objectively and subjectively compared for determination of which layout could optimize the sound of the orchestra and revitalize the excitement of the performance.

  5. Joint Graph Layouts for Visualizing Collections of Segmented Meshes

    KAUST Repository

    Ren, Jing

    2017-09-12

    We present a novel and efficient approach for computing joint graph layouts and then use it to visualize collections of segmented meshes. Our joint graph layout algorithm takes as input the adjacency matrices for a set of graphs along with partial, possibly soft, correspondences between nodes of different graphs. We then use a two stage procedure, where in the first step, we extend spectral graph drawing to include a consistency term so that a collection of graphs can be handled jointly. Our second step extends metric multi-dimensional scaling with stress majorization to the joint layout setting, while using the output of the spectral approach as initialization. Further, we discuss a user interface for exploring a collection of graphs. Finally, we show multiple example visualizations of graphs stemming from collections of segmented meshes and we present qualitative and quantitative comparisons with previous work.

  6. Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters.

    Science.gov (United States)

    Zheng, Wei Hao; Västermark, Åke; Shlykov, Maksim A; Reddy, Vamsee; Sun, Eric I; Saier, Milton H

    2013-05-06

    The ATP-Binding Cassette (ABC) functional superfamily includes integral transmembrane exporters that have evolved three times independently, forming three families termed ABC1, ABC2 and ABC3, upon which monophyletic ATPases have been superimposed for energy-coupling purposes [e.g., J Membr Biol 231(1):1-10, 2009]. The goal of the work reported in this communication was to understand how the integral membrane constituents of ABC uptake transporters with different numbers of predicted or established transmembrane segments (TMSs) evolved. In a few cases, high resolution 3-dimensional structures were available, and in these cases, their structures plus primary sequence analyses allowed us to predict evolutionary pathways of origin. All of the 35 currently recognized families of ABC uptake proteins except for one (family 21) were shown to be homologous using quantitative statistical methods. These methods involved using established programs that compare native protein sequences with each other, after having compared each sequence with thousands of its own shuffled sequences, to gain evidence for homology. Topological analyses suggested that these porters contain numbers of TMSs ranging from four or five to twenty. Intragenic duplication events occurred multiple times during the evolution of these porters. They originated from a simple primordial protein containing 3 TMSs which duplicated to 6 TMSs, and then produced porters of the various topologies via insertions, deletions and further duplications. Except for family 21 which proved to be related to ABC1 exporters, they are all related to members of the previously identified ABC2 exporter family. Duplications that occurred in addition to the primordial 3 → 6 duplication included 5 → 10, 6 → 12 and 10 → 20 TMSs. In one case, protein topologies were uncertain as different programs gave discrepant predictions. It could not be concluded with certainty whether a 4 TMS ancestral protein or a 5 TMS ancestral protein

  7. Private drinking water quality in rural Wisconsin.

    Science.gov (United States)

    Knobeloch, Lynda; Gorski, Patrick; Christenson, Megan; Anderson, Henry

    2013-03-01

    Between July 1, 2007, and December 31, 2010, Wisconsin health departments tested nearly 4,000 rural drinking water supplies for coliform bacteria, nitrate, fluoride, and 13 metals as part of a state-funded program that provides assistance to low-income families. The authors' review of laboratory findings found that 47% of these wells had an exceedance of one or more health-based water quality standards. Test results for iron and coliform bacteria exceeded safe limits in 21% and 18% of these wells, respectively. In addition, 10% of the water samples from these wells were high in nitrate and 11% had an elevated result for aluminum, arsenic, lead, manganese, or strontium. The high percentage of unsafe test results emphasizes the importance of water quality monitoring to the health of nearly one million families including 300,000 Wisconsin children whose drinking water comes from a privately owned well.

  8. An Evolutionary Approach for Robust Layout Synthesis of MEMS

    DEFF Research Database (Denmark)

    Fan, Zhun; Wang, Jiachuan; Goodman, Erik

    2005-01-01

    The paper introduces a robust design method for layout synthesis of MEM resonators subject to inherent geometric uncertainties such as the fabrication error on the sidewall of the structure. The robust design problem is formulated as a multi-objective constrained optimisation problem after certain...... assumptions and treated with multiobjective genetic algorithm (MOGA), a special type of evolutionary computing approaches. Case study based on layout synthesis of a comb-driven MEM resonator shows that the approach proposed in this paper can lead to design results that meet the target performance and are less...

  9. AN ALGORITHM FOR ASSEMBLING A COMMON IMAGE OF VLSI LAYOUT

    Directory of Open Access Journals (Sweden)

    Y. Y. Lankevich

    2015-01-01

    Full Text Available We consider problem of assembling a common image of VLSI layout. Common image is composedof frames obtained by electron microscope photographing. Many frames require a lot of computation for positioning each frame inside the common image. Employing graphics processing units enables acceleration of computations. We realize algorithms and programs for assembling a common image of VLSI layout. Specificity of this work is to use abilities of CUDA to reduce computation time. Experimental results show efficiency of the proposed programs.

  10. Complete PCB design using OrCAD capture and layout

    CERN Document Server

    Mitzner, Kraig

    2011-01-01

    This book provides instruction on how to use the OrCAD design suite to design and manufacture printed circuit boards. The book is written for both students and practicing engineers who need a quick tutorial on how to use the software and who need in-depth knowledge of the capabilities and limitations of the software package. There are two goals the book aims to reach:The primary goal is to show the reader how to design a PCB using OrCAD Capture and OrCAD Layout. Capture is used to build the schematic diagram of the circuit, and Layout is used to design the circuit board so that

  11. Urban pattern: Layout design by hierarchical domain splitting

    KAUST Repository

    Yang, Yongliang

    2013-11-06

    We present a framework for generating street networks and parcel layouts. Our goal is the generation of high-quality layouts that can be used for urban planning and virtual environments. We propose a solution based on hierarchical domain splitting using two splitting types: streamline-based splitting, which splits a region along one or multiple streamlines of a cross field, and template-based splitting, which warps pre-designed templates to a region and uses the interior geometry of the template as the splitting lines. We combine these two splitting approaches into a hierarchical framework, providing automatic and interactive tools to explore the design space.

  12. Wisconsin Earth and Space Science Education

    Science.gov (United States)

    Bilbrough, Larry (Technical Monitor); French, George

    2003-01-01

    The Wisconsin Earth and Space Science Education project successfilly met its objectives of creating a comprehensive online portfolio of science education curricular resources and providing a professional development program to increase educator competency with Earth and Space science content and teaching pedagogy. Overall, 97% of participants stated that their experience was either good or excellent. The favorable response of participant reactions to the professional development opportunities highlights the high quality of the professional development opportunity. The enthusiasm generated for using the curricular material in classroom settings was overwhelmingly positive at 92%. This enthusiasm carried over into actual classroom implementation of resources from the curricular portfolio, with 90% using the resources between 1-6 times during the school year. The project has had a positive impact on student learning in Wisconsin. Although direct measurement of student performance is not possible in a project of this kind, nearly 75% of participating teachers stated that they saw an increase in student performance in math and science as a result of using project resources. Additionally, nearly 75% of participants saw an increase in the enthusiasm of students towards math and science. Finally, some evidence exists that the professional development academies and curricular portfolio have been effective in changing educator behavior. More than half of all participants indicated that they have used more hands-on activities as a result of the Wisconsin Earth and Space Science Education project.

  13. Human ATP-binding cassette (ABC transporter family

    Directory of Open Access Journals (Sweden)

    Vasiliou Vasilis

    2009-04-01

    Full Text Available Abstract There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC transporters are an example of ATP-dependent pumps. ABC transporters are ubiquitous membrane-bound proteins, present in all prokaryotes, as well as plants, fungi, yeast and animals. These pumps can move substrates in (influx or out (efflux of cells. In mammals, ABC transporters are expressed predominantly in the liver, intestine, blood-brain barrier, blood-testis barrier, placenta and kidney. ABC proteins transport a number of endogenous substrates, including inorganic anions, metal ions, peptides, amino acids, sugars and a large number of hydrophobic compounds and metabolites across the plasma membrane, and also across intracellular membranes. The human genome contains 49 ABC genes, arranged in eight subfamilies and named via divergent evolution. That ABC genes are important is underscored by the fact that mutations in at least I I of these genes are already known to cause severe inherited diseases (eg cystic fibrosis and X-linked adrenoleukodystrophy [X-ALD]. ABC transporters also participate in the movement of most drugs and their metabolites across cell surface and cellular organelle membranes; thus, defects in these genes can be important in terms of cancer therapy, pharmacokinetics and innumerable pharmacogenetic disorders.

  14. A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae

    NARCIS (Netherlands)

    Dermauw, W.; Osborne, E.J.; Clark, R.M.; Grbić, M.; Tirry, L.; Van Leeuwen, T.

    2013-01-01

    Background: The ABC (ATP-binding cassette) gene superfamily is widespread across all living species. The majority of ABC genes encode ABC transporters, which are membrane-spanning proteins capable of transferring substrates across biological membranes by hydrolyzing ATP. Although ABC transporters

  15. A Novel DBC Layout for Current Imbalance Mitigation in SiC MOSFET Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong; Munk-Nielsen, Stig; Beczkowski, Szymon

    2016-01-01

    This letter proposes a novel direct bonded copper (DBC) layout for mitigating the current imbalance among the paralleled SiC MOSFET dies in multichip power modules. Compared to the traditional layout, the proposed DBC layout significantly reduces the circuit mismatch and current coupling effect......, which consequently improves the current sharing among the paralleled SiC MOSFET dies in power module. Mathematic analysis and circuit model of the DBC layout are presented to elaborate the superior features of the proposed DBC layout. Simulation and experimental results further verify the theoretical...... analysis and current balancing performance of the proposed DBC layout....

  16. A Novel DBC Layout for Current Imbalance Mitigation in SiC MOSFET Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong; Munk-Nielsen, Stig; Beczkowski, Szymon

    2016-01-01

    This paper proposes a novel Direct Bonded Copper (DBC) layout for mitigating the current imbalance among the paralleled SiC MOSFET dies in multichip power modules. Compared to the traditional layout, the proposed DBC layout significantly reduces the circuit mismatch and current coupling effect......, which consequently improves the current sharing among the paralleled SiC MOSFET dies in power module. Mathematic analysis and circuit model of the DBC layout are presented to elaborate on the superior features of the proposed DBC layout. Simulation and experimental results further verify the theoretical...... analysis and current balancing performance of the proposed DBC layout....

  17. Product Category Layout and Organization: Retail Placement of Food Products

    NARCIS (Netherlands)

    Herpen, van E.

    2016-01-01

    This article discusses the placement of food products in retail stores, in particular how the placement of food products can influence how consumers perceive the store in general and these products in particular. It reviews the overall layout of the store, assortment organization, and shelf

  18. Creating a Single South African Keyboard Layout to Promote ...

    African Journals Online (AJOL)

    R.B. Ruthven

    frequently, the high frequency characters could be placed on keys which are easy to reach. This would create the best keyboard for speed of typing in a given language. The current QWERTY keyboard layout was designed to slow people down when using the first mechanical typewriters; it was not designed for speed.

  19. Seismic analysis of a reactor building with eccentric layout

    International Nuclear Information System (INIS)

    Itoh, T.; Deng, D.Z.F.; Lui, K.

    1987-01-01

    Conventional design for a reactor building in a high seismic area has adopted an essentially concentric layout in response to fear of excessive torsional effect due to horizontal seismic load on an eccentric plant. This concentric layout requirement generally results in an inflexible arrangement of the plant facilities and thus increases the plant volume. This study is performed to investigate the effect of eccentricity on the overall seismic structural response and to provide technical information in this regard to substantiate the volume reduction of the overall power plant. The plant layout is evolved from the Bechtel standard plan of a PWR plant by integrating the reactor building and the auxiliary building into a combined building supported on a common basemat. This plant layout is optimized for volume utilization and to reduce the length of piping systems. The mass centers at various elevations of the combined building do not coincide with the rigidity center (RC) of the respective floor and the geometric center of the basemat, thus creating an eccentric response of the building in a seismic environment. Therefore, the torsional effects of the structure have to be taken into account in the seismic analysis

  20. An online planning tool for designing terrace layouts

    Science.gov (United States)

    A web-based conservation planning tool, WebTERLOC (web-based Terrace Location Program), was developed to provide multiple terrace layout options using digital elevation model (DEM) and geographic information systems (GIS). Development of a terrace system is complicated by the time-intensive manual ...

  1. Offshore Wind Farm Layout Design Considering Optimized Power Dispatch Strategy

    DEFF Research Database (Denmark)

    Hou, Peng; Hu, Weihao; N. Soltani, Mohsen

    2017-01-01

    Offshore wind farm has drawn more and more attention recently due to its higher energy capacity and more freedom to occupy area. However, the investment is higher. In order to make a cost-effective wind farm, the wind farm layout should be optimized. The wake effect is one of the dominant factors...

  2. Why multicamp layouts? | BR | African Journal of Range and Forage ...

    African Journals Online (AJOL)

    Although it has become standard practice in Southern Africa to recommend grazing systems based on a maximum of five camps, there are indications that the use of multicamp layouts, employing a greater number of camps per herd, may increase the efficiency of animal production from natural veld. The basic advantage of ...

  3. FOOD safety and hygiene - Systematic layout planning of food processes

    NARCIS (Netherlands)

    Van Donk, DP; Gaalman, G

    2004-01-01

    Hygiene and food safety have been dealt with from different fields of science such as biology and health, and from different angles such as HACCP and GMP. Little systematically ordered knowledge is available for the analysis of a layout, taking hygienic factors into account. HACCP and GMP are

  4. Hydrodynamic Modelling and Layout Optimisation of Wave Energy Converter Arrays

    DEFF Research Database (Denmark)

    Ruiz, Pau Mercadé

    2017-01-01

    in various positions and orientations are finally investigated. This thesis intends in this way to offer a practical approach to the analysis of wave energy converters when they operate together as an array and the optimal design of array layouts. The topics covered by the text include propagation of waves...

  5. Representing Spatial Layout According to Intrinsic Frames of Reference.

    Science.gov (United States)

    Xie, Chaoxiang; Li, Shiyi; Tao, Weidong; Wei, Yiping; Sun, Hong-Jin

    2017-01-01

    Mou and McNamara have suggested that object locations are represented according to intrinsic reference frames. In three experiments, we investigated the limitations of intrinsic reference frames as a mean to represent object locations in spatial memory. Participants learned the locations of seven or eight common objects in a rectangular room and then made judgments of relative direction based on their memory of the layout. The results of all experiments showed that when all objects were positioned regularly, judgments of relative direction were faster or more accurate for novel headings that were aligned with the primary intrinsic structure than for other novel headings; however, when one irregularly positioned object was added to the layout, this advantage was eliminated. The experiments further indicated that with a single view at study, participants could represent the layout from either an egocentric orientation or a different orientation, according to experimental instructions. Together, these results suggest that environmental reference frames and intrinsic axes can influence performance for novel headings, but their role in spatial memory depends on egocentric experience, layout regularity, and instructions.

  6. CONTROLLABILITY OF TRADITIONAL NEIGHBORHOOD AND ITS SIMPLIFIED LAYOUT

    Directory of Open Access Journals (Sweden)

    M. Salim Ferwati

    2010-03-01

    Full Text Available Street hierarchy, as a way of presenting intended information, conforms to social rules that underlay architectural and urban designs to create public, semi-public, and semi-private. These social rules have the responsibility to convey necessary information about place to outsiders as well as to insiders. This research looks at urban spaces as physical structures that represent foci of attention of users and that are collectively a part of the social pattern framework. The argument of this study is that connectivity and forms of streets house certain social rules that intended to serve users, so that any changes in the street layout lead to changes in its social rules. As a case study, the complexity of a walled Arab neighborhood was examined through Sur Lawatyia, located in Muscat Governorate, Oman. By replacing the curvilinear and broken streets of this neighborhood with straight ones; a simplified street layout was derived. Then, a comparison of both street layouts was carried out through mapping, tabulation, charts, correlation test, and with reliance on the method of measurement of street control values introduced by Hillier and Hanson in 1984. The result was that the simple form is far short to be the representation of the space syntax of the traditional street layout.

  7. How to Choose the Network Layout That's Right for You.

    Science.gov (United States)

    Farmer, Lesley S. J.

    1995-01-01

    Examines major network structures and provides criteria for selecting the best layout. Describes daisy-chain, star, bus, tree, ring, and token ring topologies. Discusses factors to consider when connecting computers, including user needs, printing demands, modem and file sharing, user grouping, the physical plant, and connective equipment. (AEF)

  8. The Influence of Facility Layout on Operations Explored

    NARCIS (Netherlands)

    Zijlstra, E.; Mobach, M.

    2011-01-01

    Purpose – The purpose of this study is to explore the influence of an office canteen layout on operations, specifically on customer behaviour before checkout, waiting times, and congestion. Design/methodology/approach – The current study was made in the context of discovery and exemplification. The

  9. Automated Layout Generation of Analogue and Mixed-Signal ASIC's

    DEFF Research Database (Denmark)

    Bloch, Rene

    The research and development carried out in this Ph.D. study focusses on two key areas of the design flow for analogue and mixed-signal integrated circuit design, the mixed-signal floorplanning and the analogue layout generation.A novel approach to floorplanning is presented which provides true i...

  10. Performance evaluation of cellular layouts : extension to DRC system contexts

    NARCIS (Netherlands)

    Suresh, NC; Gaalman, GJC

    2000-01-01

    This study involves a comparison of the performance of functional layouts (FL) and cellular manufacturing (CM) systems in a dual-resource-constrained( DRC) system context. Past studies of FL and CM have been based mostly on single-resource-constrained( SRC) systems. Recent studies have included

  11. Generation of printed circuit board layout and artwork | Debretsion ...

    African Journals Online (AJOL)

    Printed circuit board (PCB) design plays an important role on equipment performance and reliability. Constraint imposed on PCB size under severe environmental condition is focused. Guidelines for layout planning, its speedy execution, component· placements, and future growth/modifications have been addressed.

  12. A New Data Layout For Set Intersection on GPUs

    DEFF Research Database (Denmark)

    Amossen, Rasmus Resen; Pagh, Rasmus

    2011-01-01

    . However, GPUs require highly regular control flow and memory access patterns, and for this reason previous GPU methods for intersecting sets have used a simple bitmap representation. This representation requires excessive space on sparse data sets. In this paper we present a novel data layout, BATMAP...

  13. Layout considerations for the PSB H- injection system

    CERN Document Server

    Aiba, M; Carli, C; Chanel, M; Fowler, A; Goddard, B; Weterings, W

    2009-01-01

    The layout of the PSB H- injection system is described, including the arguments for the geometry and the required equipment performance parameters. The longitudinal positions of the main elements are specified, together with the injected and circulating beam axes. The assumptions used in determining the geometry are listed.

  14. Genetic algorithms for construction site layout in project planning

    NARCIS (Netherlands)

    Mawdesley, Michael J.; Al-Jibouri, Saad H.S.; Yang, Hongbo

    2002-01-01

    Construction site layout is concerned with the existence, positioning, and timing of the temporary facilities that are used to carry out a construction project. Typically these problems are very complicated to formulate and difficult to solve. They are, however, very important to virtually any

  15. Integrated quadratic assignment and continuous facility layout problem

    Directory of Open Access Journals (Sweden)

    Mohammad Mohammadi

    2012-10-01

    Full Text Available In this paper, an integrated layout model has been considered to incorporate intra and inter-department layout. In the proposed model, the arrangement of facilities within the departments is obtained through the QAP and from the other side the continuous layout problem is implemented to find the position and orientation of rectangular shape departments on the planar area. First, a modified version of QAP with fewer binary variables is presented. Afterward the integrated model is formulated based on the developed QAP. In order to evaluate material handling cost precisely, the actual position of machines within the departments (instead of center of departments is considered. Moreover, other design factors such as aisle distance, single or multi row intra-department layout and orientation of departments have been considered. The mathematical model is formulated as mixed-integer programming (MIP to minimize total material handling cost. Also due to the complexity of integrated model a heuristic method has been developed to solve large scale problems in a reasonable computational time. Finally, several illustrative numerical examples are selected from the literature to test the model and evaluate the heuristic.

  16. Layout pattern analysis using the Voronoi diagram of line segments

    Science.gov (United States)

    Dey, Sandeep Kumar; Cheilaris, Panagiotis; Gabrani, Maria; Papadopoulou, Evanthia

    2016-01-01

    Early identification of problematic patterns in very large scale integration (VLSI) designs is of great value as the lithographic simulation tools face significant timing challenges. To reduce the processing time, such a tool selects only a fraction of possible patterns which have a probable area of failure, with the risk of missing some problematic patterns. We introduce a fast method to automatically extract patterns based on their structure and context, using the Voronoi diagram of line-segments as derived from the edges of VLSI design shapes. Designers put line segments around the problematic locations in patterns called "gauges," along which the critical distance is measured. The gauge center is the midpoint of a gauge. We first use the Voronoi diagram of VLSI shapes to identify possible problematic locations, represented as gauge centers. Then we use the derived locations to extract windows containing the problematic patterns from the design layout. The problematic locations are prioritized by the shape and proximity information of the design polygons. We perform experiments for pattern selection in a portion of a 22-nm random logic design layout. The design layout had 38,584 design polygons (consisting of 199,946 line segments) on layer Mx, and 7079 markers generated by an optical rule checker (ORC) tool. The optical rules specify requirements for printing circuits with minimum dimension. Markers are the locations of some optical rule violations in the layout. We verify our approach by comparing the coverage of our extracted patterns to the ORC-generated markers. We further derive a similarity measure between patterns and between layouts. The similarity measure helps to identify a set of representative gauges that reduces the number of patterns for analysis.

  17. ABC's of Being Smart: I Can "C" Clearly Now

    Science.gov (United States)

    Foster, Joanne

    2011-01-01

    In this paper, the author focuses on C of the ABC's of being smart. She continues to categorize the points for readers. These categories include the following: (1) being; (2) doing; and (3) stretching.

  18. Compilation of accelerated bridge construction (ABC) bridges : final report.

    Science.gov (United States)

    2016-01-01

    Development of accelerated bridge construction (ABC) technologies has been occurring across the country, many times in : isolation. Although FHWA and others have worked to facilitate communication between these efforts, there was not a : comprehensiv...

  19. ABC proteins protect the human body and maintain optimal health.

    Science.gov (United States)

    Ueda, Kazumitsu

    2011-01-01

    Human MDR1, a multi-drug transporter gene, was isolated as the first of the eukaryote ATP Binding Cassette (ABC) proteins from a multidrug-resistant carcinoma cell line in 1986. To date, over 25 years, many ABC proteins have been found to play important physiological roles by transporting hydrophobic compounds. Defects in their functions cause various diseases, indicating that endogenous hydrophobic compounds, as well as water-soluble compounds, are properly transported by transmembrane proteins. MDR1 transports a large number of structurally unrelated drugs and is involved in their pharmacokinetics, and thus is a key factor in drug interaction. ABCA1, an ABC protein, eliminates excess cholesterol in peripheral cells by generating HDL. Because ABCA1 is a key molecule in cholesterol homeostasis, its function and expression are highly regulated. Eukaryote ABC proteins function on the body surface facing the outside and in organ pathways to adapt to the extracellular environment and protect the body to maintain optimal health.

  20. ABC-B transporter genes in Dirofilaria immitis.

    Science.gov (United States)

    Bourguinat, Catherine; Che, Hua; Mani, Thangadurai; Keller, Kathy; Prichard, Roger K

    2016-08-01

    Dirofilaria immitis is a filarial nematode causing infection and heartworm disease in dogs and other canids, cats, and occasionally in humans. Prevention with macrocyclic lactones (ML) is recommended during the mosquito transmission season. Recently, ML resistance has been reported. ABC-B transporter genes are thought to be involved in the mechanism of ML resistance in other nematodes. This study aimed to identify all the ABC-B transporter genes in D. immitis using as a reference the nDi.2.2 D. immitis whole genome, which is not completely annotated. Using bioinformatic tools and PCR amplification on pooled D. immitis genomic DNA and on pooled cDNA, nine ABC transporter genes including one pseudogene were characterized. Bioinformatic and phylogenetic analyses allowed identification of three P-glycoproteins (Pgps) (Dim-pgp-3 Dim-pgp-10, Dim-pgp-11), of two ABC-B half transporter genes (one ortholog of Cel-haf-4 and Cel-haf-9; and one ortholog of Cel-haf-1 and Cel-haf-3), of one ABC half transporter gene (ortholog of Cel-haf-5) that contained an ABC-C motif, and of one additional half transporter that would require functional study for characterization. The number of ABC-B transporter genes identified was lower than in Caenorhabditis elegans and Haemonchus contortus. Further studies are needed to understand their possible role in ML resistance in D. immitis. These ABC transporters constitute a base for ML resistance investigation in D. immitis and advance our understanding of the molecular biology of this parasite. Copyright © 2016. Published by Elsevier Ltd.

  1. Application of the ABC analysis in management of food inventory

    OpenAIRE

    Radek Toušek

    2009-01-01

    The article is focused on managing stock inventory with help of the ABC method. The theory is explained on an actual company dealing with retail grocery distribution within the south bohemian region. The ABC method is applied on 4,405 inventory items regarding their 2008 year turnover. Results of the analysis are processed into a system plan to reduce the asset liability and decrease the stock inventory while maintaining the requested quality of logistic services.

  2. Polymorphism in ABC transporter genes of Dirofilaria immitis

    Directory of Open Access Journals (Sweden)

    Thangadurai Mani

    2017-08-01

    Full Text Available Dirofilaria immitis, a filarial nematode, causes dirofilariasis in dogs, cats and occasionally in humans. Prevention of the disease has been mainly by monthly use of the macrocyclic lactone (ML endectocides during the mosquito transmission season. Recently, ML resistance has been confirmed in D. immitis and therefore, there is a need to find new classes of anthelmintics. One of the mechanisms associated with ML resistance in nematodes has been the possible role of ATP binding cassette (ABC transporters in reducing drug concentrations at receptor sites. ABC transporters, mainly from sub-families B, C and G, may contribute to multidrug resistance (MDR by active efflux of drugs out of the cell. Gene products of ABC transporters may thus serve as the targets for agents that may modulate susceptibility to drugs, by inhibiting drug transport. ABC transporters are believed to be involved in a variety of physiological functions critical to the parasite, such as sterol transport, and therefore may also serve as the target for drugs that can act as anthelmintics on their own. Knowledge of polymorphism in these ABC transporter genes in nematode parasites could provide useful information for the process of drug design. We have identified 15 ABC transporter genes from sub-families A, B, C and G, in D. immitis, by comparative genomic approaches and analyzed them for polymorphism. Whole genome sequencing data from four ML susceptible (SUS and four loss of efficacy (LOE pooled populations were used for single nucleotide polymorphism (SNP genotyping. Out of 231 SNPs identified in those 15 ABC transporter genes, 89 and 75 of them were specific to the SUS or LOE populations, respectively. A few of the SNPs identified may affect gene expression, protein function, substrate specificity or resistance development and may be useful for transporter inhibitor/anthelmintic drug design, or in order to anticipate resistance development. Keywords: Dirofilaria immitis

  3. Elements of Instruction VTAE Workshop (Wisconsin Rapids, Wisconsin, March 7-9, 1989). Final Report.

    Science.gov (United States)

    Lee, Howard D.

    This document describes a 3-day Wisconsin workshop on essential elements of instruction in vocational, technical, and adult education (VTAE). The workshop's content was based on the Univesity of California at Los Angeles' Teaching Model, which resulted from the work of Madeline Hunter. A three-page narrative describes some aspects of the model,…

  4. Improved Differential Evolution Based on Stochastic Ranking for Robust Layout Synthesis of MEMS Components

    DEFF Research Database (Denmark)

    Fan, Zhun; Liu, Jinchao; Sørensen, Torben

    2009-01-01

    This paper introduces an improved differential evolution (DE) algorithm for robust layout synthesis of microelectromechanical system components subject to inherent geometric uncertainties. A case study of the layout synthesis of a combdriven microresonator shows that the approach proposed...

  5. Quality of Wisconsin stormwater, 1989-94

    Science.gov (United States)

    Bannerman, Roger T.; Legg, Andrew D.; Greb, Steven R.

    1996-01-01

    Water-quality data were compiled from four urban stormwater monitoring projects conducted in Wisconsin between 1989 and 1994. These projects included monitoring in both storm-sewer pipes and urban streams. A total of 147 constitu ents were analyzed for in stormwater sampled from 10 storm-sewer pipes and four urban streams. Land uses represented by the storm-sewer watersheds included residential, commercial, industrial, and mixed. For about one-half the con stituents, at least 10 percent of the event mean con centrations exceeded the laboratory's minimum reporting limit. Detection frequencies were greater than 75 percent for many of the heavy metals and polycyclic aromatic hydrocarbons in both the storm sewer and stream samples, whereas detec tion frequencies were about 20 percent or greater for many of the pesticides in both types of sam ples. Stormwater concentrations for conventional constituents, such as suspended solids, chloride, total phosphorus, and fecal coliform bacteria were greater than minimum reporting limits almost 100 percent of the time. Concentrations of many of the constituents were high enough to say that stormwater in the storm sewers and urban streams might be contrib uting to the degradation of the streams. In this report, constituents defined as potential contami nants are those for which the laboratory minimum report limit was exceeded for at least 10 percent of the sampled storm events, and for which at least one event mean concentration exceeded an estab lished water-quality standard. Storm-sewer sam ples had event mean concentrations of lead, copper, zinc, cadmium, and silver that frequently exceeded Wisconsin's acute toxicity criteria for cold water fisheries. Wisconsin's human cancer criteria was exceeded almost 100 percent of the time for polycyclic aromatic hydrocarbons in stormwater samples from storm sewers and streams. Maximum concentrations of diazinon found in storm sewers exceeded recommended levels of diazinon. Storm

  6. ABC transporter research: going strong 40 years on.

    Science.gov (United States)

    Theodoulou, Frederica L; Kerr, Ian D

    2015-10-01

    In most organisms, ABC transporters constitute one of the largest families of membrane proteins. In humans, their functions are diverse and underpin numerous key physiological processes, as well as being causative factors in a number of clinically relevant pathologies. Advances in our understanding of these diseases have come about through combinations of genetic and protein biochemical investigations of these transporters and the power of in vitro and in vivo investigations is helping to develop genotype-phenotype understanding. However, the importance of ABC transporter research goes far beyond human biology; microbial ABC transporters are of great interest in terms of understanding virulence and drug resistance and industrial biotechnology researchers are exploring the potential of prokaryotic ABC exporters to increase the capacity of synthetic biology systems. Plant ABC transporters play important roles in transport of hormones, xenobiotics, metals and secondary metabolites, pathogen responses and numerous aspects of development, all of which are important in the global food security area. For 3 days in Chester, this Biochemical Society Focused Meeting brought together researchers with diverse experimental approaches and with different fundamental questions, all of which are linked by the commonality of ABC transporters. © 2015 Authors.

  7. ABC Transport Proteins in Cardiovascular Disease-A Brief Summary.

    Science.gov (United States)

    Schumacher, Toni; Benndorf, Ralf A

    2017-04-06

    Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in cholesterol homeostasis, blood pressure regulation, endothelial function, vascular inflammation, as well as platelet production and aggregation. In this regard, ABC transporters, such as ABCA1, ABCG5 and ABCG8, were initially found to be responsible for genetically-inherited syndromes like Tangier diseases and sitosterolemia. These findings led to the understanding of those transporter's function in cellular cholesterol efflux and thereby also linked them to atherosclerosis and cardiovascular diseases (CVD). Subsequently, further ABC transporters, i.e., ABCG1, ABCG4, ABCB6, ABCC1, ABCC6 or ABCC9, have been shown to directly or indirectly affect cellular cholesterol efflux, the inflammatory response in macrophages, megakaryocyte proliferation and thrombus formation, as well as vascular function and blood pressure, and may thereby contribute to the pathogenesis of CVD and its complications. Furthermore, ABC transporters, such as ABCB1, ABCC2 or ABCG2, may affect the safety and efficacy of several drug classes currently in use for CVD treatment. This review will give a brief overview of ABC transporters involved in the process of atherogenesis and CVD pathology. It also aims to briefly summarize the role of ABC transporters in the pharmacokinetics and disposition of drugs frequently used to treat CVD and CVD-related complications.

  8. Structural basis for the mechanism of ABC transporters.

    Science.gov (United States)

    Beis, Konstantinos

    2015-10-01

    The ATP-binding cassette (ABC) transporters are primary transporters that couple the energy stored in adenosine triphosphate (ATP) to the movement of molecules across the membrane. ABC transporters can be divided into exporters and importers; importers mediate the uptake of essential nutrients into cells and are found predominantly in prokaryotes whereas exporters transport molecules out of cells or into organelles and are found in all organisms. ABC exporters have been linked with multi-drug resistance in both bacterial and eukaryotic cells. ABC transporters are powered by the hydrolysis of ATP and transport their substrate via the alternating access mechanism, whereby the protein alternates between a conformation in which the substrate-binding site is accessible from the outside of the membrane, outward-facing and one in which it is inward-facing. In this mini-review, the structures of different ABC transporter types in different conformations are presented within the context of the alternating access mechanism and how they have shaped our current understanding of the mechanism of ABC transporters. © 2015 Authors; published by Portland Press Limited.

  9. ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance.

    Science.gov (United States)

    Begicevic, Romana-Rea; Falasca, Marco

    2017-11-08

    The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of the major obstacles to overcome in achieving lasting remission and a definitive cure in patients with cancer is the emergence of cancer resistance. Indeed, drug resistance is ultimately accountable for poor treatment outcomes and tumour relapse. There are various molecular mechanisms involved in multidrug resistance, such as the change in the activity of membrane transporters primarily belonging to the ATP binding cassette (ABC) transporter family. In addition, it has been proposed that this common feature could be attributed to a subpopulation of slow-cycling cancer stem cells (CSCs), endowed with enhanced tumorigenic potential and multidrug resistance. CSCs are characterized by the overexpression of specific surface markers that vary in different cancer cell types. Overexpression of ABC transporters has been reported in several cancers and more predominantly in CSCs. While the major focus on the role played by ABC transporters in cancer is polarized by their involvement in chemoresistance, emerging evidence supports a more active role of these proteins, in which they release specific bioactive molecules in the extracellular milieu. This review will outline our current understanding of the role played by ABC transporters in CSCs, how their expression is regulated and how they support the malignant metabolic phenotype. To summarize, we suggest that the increased expression of ABC transporters in CSCs may have precise functional roles and provide the opportunity to target, particularly these cells, by using specific ABC transporter inhibitors.

  10. ABCE1 is a highly conserved RNA silencing suppressor.

    Directory of Open Access Journals (Sweden)

    Kairi Kärblane

    Full Text Available ATP-binding cassette sub-family E member 1 (ABCE1 is a highly conserved protein among eukaryotes and archaea. Recent studies have identified ABCE1 as a ribosome-recycling factor important for translation termination in mammalian cells, yeast and also archaea. Here we report another conserved function of ABCE1. We have previously described AtRLI2, the homolog of ABCE1 in the plant Arabidopsis thaliana, as an endogenous suppressor of RNA silencing. In this study we show that this function is conserved: human ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans. Using co-immunoprecipitation and mass spectrometry, we found a number of potential ABCE1-interacting proteins that might support its function as an endogenous suppressor of RNA interference. The interactor candidates are associated with epigenetic regulation, transcription, RNA processing and mRNA surveillance. In addition, one of the identified proteins is translin, which together with its binding partner TRAX supports RNA interference.

  11. ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance

    Directory of Open Access Journals (Sweden)

    Romana-Rea Begicevic

    2017-11-01

    Full Text Available The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of the major obstacles to overcome in achieving lasting remission and a definitive cure in patients with cancer is the emergence of cancer resistance. Indeed, drug resistance is ultimately accountable for poor treatment outcomes and tumour relapse. There are various molecular mechanisms involved in multidrug resistance, such as the change in the activity of membrane transporters primarily belonging to the ATP binding cassette (ABC transporter family. In addition, it has been proposed that this common feature could be attributed to a subpopulation of slow-cycling cancer stem cells (CSCs, endowed with enhanced tumorigenic potential and multidrug resistance. CSCs are characterized by the overexpression of specific surface markers that vary in different cancer cell types. Overexpression of ABC transporters has been reported in several cancers and more predominantly in CSCs. While the major focus on the role played by ABC transporters in cancer is polarized by their involvement in chemoresistance, emerging evidence supports a more active role of these proteins, in which they release specific bioactive molecules in the extracellular milieu. This review will outline our current understanding of the role played by ABC transporters in CSCs, how their expression is regulated and how they support the malignant metabolic phenotype. To summarize, we suggest that the increased expression of ABC transporters in CSCs may have precise functional roles and provide the opportunity to target, particularly these cells, by using specific ABC transporter inhibitors.

  12. Mixing zones studies of the waste water discharge from the Consolidated Paper Company into the Wisconsin River at Wisconsin Rapids, Wisconsin

    Science.gov (United States)

    Hoopes, J. A.; Wu, D. S.; Ganatra, R.

    1973-01-01

    Effluent concentration distributions from the waste water discharge of the Kraft Division Mill, Consolidated Paper Company, into the Wisconsin River at Wisconsin Rapids, Wisconsin, is investigated. Effluent concentrations were determined from measurements of the temperature distribution, using temperature as a tracer. Measurements of the velocity distribution in the vicinity of the outfall were also made. Due to limitations in the extent of the field observations, the analysis and comparison of the measurements is limited to the region within about 300 feet from the outfall. Effects of outfall submergence, of buoyancy and momentum of the effluent and of the pattern and magnitude of river currents on these characteristics are considered.

  13. Flood-frequency characteristics of Wisconsin streams

    Science.gov (United States)

    Walker, John F.; Peppler, Marie C.; Danz, Mari E.; Hubbard, Laura E.

    2017-05-22

    Flood-frequency characteristics for 360 gaged sites on unregulated rural streams in Wisconsin are presented for percent annual exceedance probabilities ranging from 0.2 to 50 using a statewide skewness map developed for this report. Equations of the relations between flood-frequency and drainage-basin characteristics were developed by multiple-regression analyses. Flood-frequency characteristics for ungaged sites on unregulated, rural streams can be estimated by use of the equations presented in this report. The State was divided into eight areas of similar physiographic characteristics. The most significant basin characteristics are drainage area, soil saturated hydraulic conductivity, main-channel slope, and several land-use variables. The standard error of prediction for the equation for the 1-percent annual exceedance probability flood ranges from 56 to 70 percent for Wisconsin Streams; these values are larger than results presented in previous reports. The increase in the standard error of prediction is likely due to increased variability of the annual-peak discharges, resulting in increased variability in the magnitude of flood peaks at higher frequencies. For each of the unregulated rural streamflow-gaging stations, a weighted estimate based on the at-site log Pearson type III analysis and the multiple regression results was determined. The weighted estimate generally has a lower uncertainty than either the Log Pearson type III or multiple regression estimates. For regulated streams, a graphical method for estimating flood-frequency characteristics was developed from the relations of discharge and drainage area for selected annual exceedance probabilities. Graphs for the major regulated streams in Wisconsin are presented in the report.

  14. A combined approach of simulation and analytic hierarchy process in assessing production facility layouts

    Science.gov (United States)

    Ramli, Razamin; Cheng, Kok-Min

    2014-07-01

    One of the important areas of concern in order to obtain a competitive level of productivity in a manufacturing system is the layout design and material transportation system (conveyor system). However, changes in customers' requirements have triggered the need to design other alternatives of the manufacturing layout for existing production floor. Hence, this paper discusses effective alternatives of the process layout specifically, the conveyor system layout. Subsequently, two alternative designs for the conveyor system were proposed with the aims to increase the production output and minimize space allocation. The first proposed layout design includes the installation of conveyor oven in the particular manufacturing room based on priority, and the second one is the one without the conveyor oven in the layout. Simulation technique was employed to design the new facility layout. Eventually, simulation experiments were conducted to understand the performance of each conveyor layout design based on operational characteristics, which include predicting the output of layouts. Utilizing the Analytic Hierarchy Process (AHP), the newly and improved layout designs were assessed before the final selection was done. As a comparison, the existing conveyor system layout was included in the assessment process. Relevant criteria involved in this layout design problem were identified as (i) usage of space of each design, (ii) operator's utilization rates, (iii) return of investment (ROI) of the layout, and (iv) output of the layout. In the final stage of AHP analysis, the overall priority of each alternative layout was obtained and thus, a selection for final use by the management was made based on the highest priority value. This efficient planning and designing of facility layout in a particular manufacturing setting is able to minimize material handling cost, minimize overall production time, minimize investment in equipment, and optimize utilization of space.

  15. Archaeological Investigations at a Wisconsin Petroglyph Site

    Directory of Open Access Journals (Sweden)

    Jack Steinbring

    2014-01-01

    Full Text Available Preliminary test excavations at the Hensler Petroglyph Site in East Central Wisconsin, U.S.A. have disclosed the remains of aboriginal engravings below Aeolian sediments dated to ca. 15,000 years B.P. The stratified deposits lying adjacent to an engraved panel, containing 35 pecked images, have yielded animal-like cobbles, some covered with red ochre, apparently picked for some esoteric use. The site itself has unusual natural shapes in the rock formation, along with acoustical properties, lightning strikes, a magnetic anomaly, and geographic prominence. Collectively these factors are thought to have attracted the ancient rock artists to the site.

  16. Wisconsin EE Mandates: The Bad News and the Good News.

    Science.gov (United States)

    Lane, Jennie; And Others

    1996-01-01

    Examines Wisconsin teachers' perceived competencies in, attitudes toward, and amount of class time devoted to teaching about the environment. Discusses the effects of Wisconsin environmental education mandates concerning preservice preparation in environmental education and K-12 environmental education curriculum plans. Identifies areas where the…

  17. Wisconsin Maternity Leave and Fringe Benefits: Policies, Practices and Problems.

    Science.gov (United States)

    Gerner, Jennifer

    The study examines the economic implications in Wisconsin of the 1972 Equal Employment Opportunity Commission guideline which requires employers to treat maternity leave as a temporary disability. First, the static cost of the maternity leave guideline to employers is estimated for the State of Wisconsin. Second, some examination of the economic…

  18. Export of recombinant proteins in Escherichia coli using ABC transporter with an attached lipase ABC transporter recognition domain (LARD

    Directory of Open Access Journals (Sweden)

    Moon Yuseok

    2009-01-01

    Full Text Available Abstract Background ATP binding cassette (ABC transporter secretes the protein through inner and outer membranes simultaneously in gram negative bacteria. Thermostable lipase (TliA of Pseudomonas fluorescens SIK W1 is secreted through the ABC transporter. TliA has four glycine-rich repeats (GGXGXD in its C-terminus, which appear in many ABC transporter-secreted proteins. From a homology model of TliA derived from the structure of P. aeruginosa alkaline protease (AprA, lipase ABC transporter domains (LARDs were designed for the secretion of fusion proteins. Results The LARDs included four glycine-rich repeats comprising a β-roll structure, and were added to the C-terminus of test proteins. Either Pro-Gly linker or Factor Xa site was added between fusion proteins and LARDs. We attached different length of LARDs such as LARD0, LARD1 or whole TliA (the longest LARD to three types of proteins; green fluorescent protein (GFP, epidermal growth factor (EGF and cytoplasmic transduction peptide (CTP. These fusion proteins were expressed in Escherichia coli together with ABC transporter of either P. fluorescens or Erwinia chrysanthemi. Export of fusion proteins with the whole TliA through the ABC transporter was evident on the basis of lipase enzymatic activity. Upon supplementation of E. coli with ABC transporter, GFP-LARDs and EGF-LARDs were excreted into the culture supernatant. Conclusion The LARDs or whole TliA were attached to C-termini of model proteins and enabled the export of the model proteins such as GFP and EGF in E. coli supplemented with ABC transporter. These results open the possibility for the extracellular production of recombinant proteins in Pseudomonas using LARDs or TliA as a C-terminal signal sequence.

  19. 29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Site layout, site-specific erection plan and construction... Steel Erection § 1926.752 Site layout, site-specific erection plan and construction sequence. (a... strength or sufficient strength to support the loads imposed during steel erection. (c) Site layout. The...

  20. 77 FR 55896 - Notice of Release Effecting Federal Grant Assurance Obligations Due to Airport Layout Plan...

    Science.gov (United States)

    2012-09-11

    ... Grant Assurance Obligations Due to Airport Layout Plan Revision at Mather Airport, Sacramento, CA AGENCY... application for an Airport Layout Plan revision effecting approximately 422 acres of airport property at... will not be conveyed by the Air Force to the County. As a result, the existing Airport Layout Plan will...

  1. Rearrangement of the layout of the welding equipment of a company in the metal mechanical sector using the Systematic Layout Planning method (SLP

    Directory of Open Access Journals (Sweden)

    Silvio Alexsandro Turati

    2016-06-01

    Full Text Available The correct physical layout is relevant to the operational efficiency of the company. This study proposes rearranging the layout of the welding equipment of a company in the metal mechanical sector, which is located in Araras/SP, aiming to improve the production workflow. The Systematic Layout Planning method (SLP was used, with the field research divided into steps: obtaining detailed information about the process and the product; meetings with stakeholders; determining inter-related activities; analyzing space requirements; developing a new layout. The new layout has space allocated for the purchasing of new machinery, the existing machinery has been redistributed by specialty, and the unloading of raw materials has been transferred to the shed, maximizing the use of overhead cranes and keeping the stock close to the warehouse. In addition, forklift traffic flow has decreased; new movement corridors were demarcated; and painting areas were isolated. In conclusion, the SLP method proved efficient in creating a layout.

  2. Optimal ABC inventory classification using interval programming

    Science.gov (United States)

    Rezaei, Jafar; Salimi, Negin

    2015-08-01

    Inventory classification is one of the most important activities in inventory management, whereby inventories are classified into three or more classes. Several inventory classifications have been proposed in the literature, almost all of which have two main shortcomings in common. That is, the previous methods mainly rely on an expert opinion to derive the importance of the classification criteria which results in subjective classification, and they need precise item parameters before implementing the classification. While the problem has been predominantly considered as a multi-criteria, we examine the problem from a different perspective, proposing a novel optimisation model for ABC inventory classification in the form of an interval programming problem. The proposed interval programming model has two important features compared to the existing methods: it provides optimal results instead of an expert-based classification and it does not require precise values of item parameters, which are not almost always available before classification. Finally, by illustrating the proposed classification model in the form of numerical example, conclusion and suggestions for future works are presented.

  3. ABC transporters in the liver fluke Opisthorchis felineus.

    Science.gov (United States)

    Mordvinov, Viatcheslav A; Ershov, Nikita I; Pirozhkova, Darya S; Pakharukov, Yuri V; Pakharukova, Maria Y

    2017-09-01

    ATP-binding cassette transporters (ABC transporters) are essential components of normal cellular physiological machinery in all eukaryotic and prokaryotic species, including parasites. Some ABC transporters, e.g., P-glycoproteins, are involved in the efflux of toxins and xenobiotics from the cell. At present, nothing is known about ABC transporter genes in epidemiologically important liver flukes from the Opisthorchiidae family, including European liver fluke Opisthorchis felineus. Opisthorchiasis caused by O. felineus is a serious public health problem on the territory of Russia and other Eastern European countries. ABC drug transporters are attractive objects of research on molecular markers of resistance and on ways to potentiate sensitivity to anthelmintics through suppression of the transporters themselves with specific inhibitors. Here we aimed at the identification of ABC transporters in the O. felineus transcriptome and identification of P-glycoproteins. In addition, our aim was to assess ABC transcript abundance in the RNA-seq data, to study the mRNA expression of P-glycoprotein genes by Droplet Digital PCR throughout the life cycle of O. felineus, and to test the gene induction in response to xenobiotics or anthelminthic agents. We found 23 nucleotide sequences encoding ABC transporters belonging to different subfamilies, including four sequences of P-glycoproteins. According to the transcript abundance in the RNA-seq data, one of P-glycoproteins (P4) has the highest expression among all ABC genes in the adult worm. P-glycoproteins showed substantially differential mRNA expression throughout the fluke life cycle, with high expression in the adult worms. Putative activity of P-glycoproteins as xenobiotic efflux pumps was found to be linked to the excretory system of O. felineus and to be inhibited by verapamil or tariquidar. Thus, ABC drug transporters in the liver fluke O. felineus are functionally active, indicating that ABC drug transporters are likely

  4. Protocol: Material flow risk evaluation for layout design

    Directory of Open Access Journals (Sweden)

    Aída Sáez Más

    2016-12-01

    Full Text Available The need of design new layouts or redesign current situation to manufacture new products has increased principally due to changes in customer demand, on both variety aspects and quantity (Lu, Shpitalni, and Gadh, 1999. The complexity increase is also associated with the traffic generated by material handling equipment. This situation can be described as unsafe for workers. Many authors defend that during layout design/redesign a risk analysis is necessary. In contrast others believe that material flow analysis should be a mainly task during this step. Therefore, in this research both considerations have been integrated. So that it is proposed a protocol to evaluate the risk generated by material flow with handling equipment in manufacturing plants. This methodology identify the process steps and propose dimensions, measurables, tools and suggestions in order to analyse and reduce risk correctly. All the above aspects are validated in a case study of a complex assembly plant in the automotive sector.

  5. Document understanding using layout styles of title page images

    Science.gov (United States)

    Sharpe, Louis H., II; Manns, Basil

    1992-08-01

    An important problem in the application of compound document architectures is the input of data from raster images. One technique is to use visual, syntactic cues found in the layout of the raster document to infer its logical structure or semantics. Another is to use context derived from characters recognized within a given block of raster data. Both character- and image- based information are considered here. A well-constrained environment is defined for use in developing rules that can be applied to basic book title page understanding. This paper identifies the attributes of title page layout objects which aid in mapping them into the fields of a simple bibliographic format. Using as input the raster images of the title page and the verso of the title page along with the ASCII output of a generic character recognition engine from these same images, a system of rules is defined for generating a marked-up text wherein key bibliographic fields may be identified.

  6. Typography and layout of technical reports - Survey of current practices

    Science.gov (United States)

    Pinelli, T. E.; Cordle, V. M.; Mccullough, R.

    1985-01-01

    As part of a review of the NASA Langley Research Center scientific and technical information program, 50 technical reports from industry, research institutions, and government agencies were systematically examined and analyzed to determine current usage and practice in regard to (1) typography, including composition method, type style, type size, and margin treatment; (2) graphic design, including layout and imposition of material on the page; and (3) physical media, including paper, ink, and binding methods. The results indicate that approximately 50 percent of the reports were typeset, 70 percent used Roman (serif) type, 80 percent used 10- or 11-point type for text, 60 percent used a ragged right-hand margin, slightly more than half used paragraph indentation, 75 percent used a single-column layout, 65 percent had one or more figures or tables placed perpendicular to (not aligned with) the text, and perfect binding was the most frequently used binding method.

  7. Dish layouts analysis method for concentrative solar power plant.

    Science.gov (United States)

    Xu, Jinshan; Gan, Shaocong; Li, Song; Ruan, Zhongyuan; Chen, Shengyong; Wang, Yong; Gui, Changgui; Wan, Bin

    2016-01-01

    Designs leading to maximize the use of sun radiation of a given reflective area without increasing the expense on investment are important to solar power plants construction. We here provide a method that allows one to compute shade area at any given time as well as the total shading effect of a day. By establishing a local coordinate system with the origin at the apex of a parabolic dish and z -axis pointing to the sun, neighboring dishes only with [Formula: see text] would shade onto the dish when in tracking mode. This procedure reduces the required computational resources, simplifies the calculation and allows a quick search for the optimum layout by considering all aspects leading to optimized arrangement: aspect ratio, shifting and rotation. Computer simulations done with information on dish Stirling system as well as DNI data released from NREL, show that regular-spacing is not an optimal layout, shifting and rotating column by certain amount can bring more benefits.

  8. A new dynamical layout algorithm for complex biochemical reaction networks

    OpenAIRE

    Kummer Ursula; Wegner Katja

    2005-01-01

    Abstract Background To study complex biochemical reaction networks in living cells researchers more and more rely on databases and computational methods. In order to facilitate computational approaches, visualisation techniques are highly important. Biochemical reaction networks, e.g. metabolic pathways are often depicted as graphs and these graphs should be drawn dynamically to provide flexibility in the context of different data. Conventional layout algorithms are not sufficient for every k...

  9. Impact of risk analysis on ITER nuclear buildings layout

    International Nuclear Information System (INIS)

    Sabathe, Laurent; Lignini, Franck; Rodriguez-Rodrigo, Lina; Uzan-Elbez, Joelle; Girard, Jean-Philippe

    2007-01-01

    The internal layout of ITER nuclear buildings (Tokamak, Tritium, Hot cell and Radwaste buildings) is the result of an iterative process. Notwithstanding civil engineering requirements, technical and functional requirements for the processes housed in the buildings, the internal layout must also take into account safety requirements and workers protection requirements in normal, incidental and accidental conditions. Potential hazards and constraints result in the definition of various zonings. Each room is classified depending on the level of the risks induced by normal and incidental or accidental conditions: - radiological exposure to tritium, and activated products → radiological zoning; - exposure to beryllium (vacuum vessel blankets) → beryllium zoning; - exposure to electromagnetic fields during plasma shots → electromagnetic zoning; - fire hazard: fire compartmentalization; ·explosion hazard: anti-blast zoning; - waste treatment → waste zoning. Prevention of common mode failure due to internal hazards (fire, flooding, load drop...) for redundant safety important components is also taken into account by geographical separation or by installation of protections between components (either in the same room or preferably when possible by segregation in different rooms). The designer has also taken into account access requirements to equipments and circulation rules for personal, material and substances in ITER nuclear buildings. Risk analyses are performed in the Preliminary Safety Report in order to demonstrate that the layout of ITER nuclear buildings allows meeting the safety objectives and takes into account the requirements associated with the zonings classifications and complies with the regulation. When necessary, modifications are implemented in the design. For example, recent layout modifications are been studied in the tritium building: utility rooms (electrical supply) were transferred outside the radiological hazard zones. A direct access from

  10. Analysis tools for the interplay between genome layout and regulation.

    Science.gov (United States)

    Bouyioukos, Costas; Elati, Mohamed; Képès, François

    2016-06-06

    Genome layout and gene regulation appear to be interdependent. Understanding this interdependence is key to exploring the dynamic nature of chromosome conformation and to engineering functional genomes. Evidence for non-random genome layout, defined as the relative positioning of either co-functional or co-regulated genes, stems from two main approaches. Firstly, the analysis of contiguous genome segments across species, has highlighted the conservation of gene arrangement (synteny) along chromosomal regions. Secondly, the study of long-range interactions along a chromosome has emphasised regularities in the positioning of microbial genes that are co-regulated, co-expressed or evolutionarily correlated. While one-dimensional pattern analysis is a mature field, it is often powerless on biological datasets which tend to be incomplete, and partly incorrect. Moreover, there is a lack of comprehensive, user-friendly tools to systematically analyse, visualise, integrate and exploit regularities along genomes. Here we present the Genome REgulatory and Architecture Tools SCAN (GREAT:SCAN) software for the systematic study of the interplay between genome layout and gene expression regulation. SCAN is a collection of related and interconnected applications currently able to perform systematic analyses of genome regularities as well as to improve transcription factor binding sites (TFBS) and gene regulatory network predictions based on gene positional information. We demonstrate the capabilities of these tools by studying on one hand the regular patterns of genome layout in the major regulons of the bacterium Escherichia coli. On the other hand, we demonstrate the capabilities to improve TFBS prediction in microbes. Finally, we highlight, by visualisation of multivariate techniques, the interplay between position and sequence information for effective transcription regulation.

  11. Impact of risk analysis on ITER nuclear buildings layout

    Energy Technology Data Exchange (ETDEWEB)

    Sabathe, Laurent [AREVA NP SAS, 10 rue Juliette Recamier, 69456 Lyon Cedex 06 (France)], E-mail: laurent.sabathe@areva.com; Lignini, Franck [AREVA NP SAS, 10 rue Juliette Recamier, 69456 Lyon Cedex 06 (France)], E-mail: franck.lignini@areva.com; Rodriguez-Rodrigo, Lina [EFDA-CSU Barcelona and Asociacion EURATOM-CIEMAT para Fusion, 08019 Barcelona (Spain); Uzan-Elbez, Joelle [Agence ITER-France, Cadarache, St Paul Lez Durance F-13108 (France); Girard, Jean-Philippe [ITER-JWS, Cadarache, St Paul Lez Durance F-13108 (France)

    2007-10-15

    The internal layout of ITER nuclear buildings (Tokamak, Tritium, Hot cell and Radwaste buildings) is the result of an iterative process. Notwithstanding civil engineering requirements, technical and functional requirements for the processes housed in the buildings, the internal layout must also take into account safety requirements and workers protection requirements in normal, incidental and accidental conditions. Potential hazards and constraints result in the definition of various zonings. Each room is classified depending on the level of the risks induced by normal and incidental or accidental conditions: - radiological exposure to tritium, and activated products {yields} radiological zoning; - exposure to beryllium (vacuum vessel blankets) {yields} beryllium zoning; - exposure to electromagnetic fields during plasma shots {yields} electromagnetic zoning; - fire hazard: fire compartmentalization; {center_dot}explosion hazard: anti-blast zoning; - waste treatment {yields} waste zoning. Prevention of common mode failure due to internal hazards (fire, flooding, load drop...) for redundant safety important components is also taken into account by geographical separation or by installation of protections between components (either in the same room or preferably when possible by segregation in different rooms). The designer has also taken into account access requirements to equipments and circulation rules for personal, material and substances in ITER nuclear buildings. Risk analyses are performed in the Preliminary Safety Report in order to demonstrate that the layout of ITER nuclear buildings allows meeting the safety objectives and takes into account the requirements associated with the zonings classifications and complies with the regulation. When necessary, modifications are implemented in the design. For example, recent layout modifications are been studied in the tritium building: utility rooms (electrical supply) were transferred outside the radiological

  12. Proximity search heuristics for wind farm optimal layout

    DEFF Research Database (Denmark)

    Fischetti, Martina; Monaci, Michele

    2016-01-01

    A heuristic framework for turbine layout optimization in a wind farm is proposed that combines ad-hoc heuristics and mixed-integer linear programming. In our framework, large-scale mixed-integer programming models are used to iteratively refine the current best solution according to the recently-......-proposed proximity search paradigm. Computational results on very large scale instances involving up to 20,000 potential turbine sites prove the practical viability of the overall approach....

  13. Metodologia ABC: implantação numa microempresa ABC methodology: implementation on a micro firm

    Directory of Open Access Journals (Sweden)

    Orlando Duran

    2000-08-01

    Full Text Available Este trabalho relata a implantação da metodologia de custos baseados em atividades numa microempresa do ramo metalúrgico. A proposta pretende demonstrar a viabilidade de aplicar esta técnica em empresas sem importar seu tamanho, só realizando algumas adaptações que garantam baixo investimento e curto espaço de tempo para obter os resultados. Na parte final do trabalho se realiza uma análise dos resultados obtidos verificando-se o potencial da informação gerada pela metodologia e seu uso como ferramenta de gestão.This paper presents an implementation of the activity based costing (ABC methodology in a small firm. The approach presented is intended to demonstrate the feasibility of applying the ABC methodology at any sized firm, only through few adaptations for ensuring low investments fees and speed in obtaining results and information from the system. Discussion about the results obtained during the implementation case are presented and the potential of using the information generated from the system as a managing tool is commented.

  14. Camera Layout Design for the Upper Stage Thrust Cone

    Science.gov (United States)

    Wooten, Tevin; Fowler, Bart

    2010-01-01

    Engineers in the Integrated Design and Analysis Division (EV30) use a variety of different tools to aid in the design and analysis of the Ares I vehicle. One primary tool in use is Pro-Engineer. Pro-Engineer is a computer-aided design (CAD) software that allows designers to create computer generated structural models of vehicle structures. For the Upper State thrust cone, Pro-Engineer was used to assist in the design of a layout for two camera housings. These cameras observe the separation between the first and second stage of the Ares I vehicle. For the Ares I-X, one standard speed camera was used. The Ares I design calls for two separate housings, three cameras, and a lighting system. With previous design concepts and verification strategies in mind, a new layout for the two camera design concept was developed with members of the EV32 team. With the new design, Pro-Engineer was used to draw the layout to observe how the two camera housings fit with the thrust cone assembly. Future analysis of the camera housing design will verify the stability and clearance of the camera with other hardware present on the thrust cone.

  15. CiSE: a circular spring embedder layout algorithm.

    Science.gov (United States)

    Dogrusoz, Ugur; Belviranli, Mehmet E; Dilek, Alptug

    2013-06-01

    We present a new algorithm for automatic layout of clustered graphs using a circular style. The algorithm tries to determine optimal location and orientation of individual clusters intrinsically within a modified spring embedder. Heuristics such as reversal of the order of nodes in a cluster and swap of neighboring node pairs in the same cluster are employed intermittently to further relax the spring embedder system, resulting in reduced inter-cluster edge crossings. Unlike other algorithms generating circular drawings, our algorithm does not require the quotient graph to be acyclic, nor does it sacrifice the edge crossing number of individual clusters to improve respective positioning of the clusters. Moreover, it reduces the total area required by a cluster by using the space inside the associated circle. Experimental results show that the execution time and quality of the produced drawings with respect to commonly accepted layout criteria are quite satisfactory, surpassing previous algorithms. The algorithm has also been successfully implemented and made publicly available as part of a compound and clustered graph editing and layout tool named CHISIO.

  16. Lower-Temperature Subsurface Layout and Ventilation Concepts

    International Nuclear Information System (INIS)

    Christine L. Linden; Edward G. Thomas

    2001-01-01

    This analysis combines work scope identified as subsurface facility (SSF) low temperature (LT) Facilities System and SSF LT Ventilation System in the Technical Work Plan for Subsurface Design Section FY 01 Work Activities (CRWMS M and O 2001b, pp. 6 and 7, and pp. 13 and 14). In accordance with this technical work plan (TWP), this analysis is performed using AP-3.10Q, Analyses and Models. It also incorporates the procedure AP-SI.1Q, Software Management. The purpose of this analysis is to develop an overall subsurface layout system and the overall ventilation system concepts that address a lower-temperature operating mode for the Monitored Geologic Repository (MGR). The objective of this analysis is to provide a technical design product that supports the lower-temperature operating mode concept for the revision of the system description documents and to provide a basis for the system description document design descriptions. The overall subsurface layout analysis develops and describes the overall subsurface layout, including performance confirmation facilities (also referred to as Test and Evaluation Facilities) for the Site Recommendation design. This analysis also incorporates current program directives for thermal management

  17. Ant colony optimization for solving university facility layout problem

    Science.gov (United States)

    Mohd Jani, Nurul Hafiza; Mohd Radzi, Nor Haizan; Ngadiman, Mohd Salihin

    2013-04-01

    Quadratic Assignment Problems (QAP) is classified as the NP hard problem. It has been used to model a lot of problem in several areas such as operational research, combinatorial data analysis and also parallel and distributed computing, optimization problem such as graph portioning and Travel Salesman Problem (TSP). In the literature, researcher use exact algorithm, heuristics algorithm and metaheuristic approaches to solve QAP problem. QAP is largely applied in facility layout problem (FLP). In this paper we used QAP to model university facility layout problem. There are 8 facilities that need to be assigned to 8 locations. Hence we have modeled a QAP problem with n ≤ 10 and developed an Ant Colony Optimization (ACO) algorithm to solve the university facility layout problem. The objective is to assign n facilities to n locations such that the minimum product of flows and distances is obtained. Flow is the movement from one to another facility, whereas distance is the distance between one locations of a facility to other facilities locations. The objective of the QAP is to obtain minimum total walking (flow) of lecturers from one destination to another (distance).

  18. ABC3 Consensus: Assessment by a German Group of Experts.

    Science.gov (United States)

    Thomssen, Christoph; Augustin, Doris; Ettl, Johannes; Haidinger, Renate; Lück, Hans-Joachim; Lüftner, Diana; Marmé, Frederik; Marschner, Norbert; Müller, Lothar; Overkamp, Friedrich; Ruckhäberle, Eugen; Thill, Marc; Untch, Michael; Wuerstlein, Rachel; Harbeck, Nadia

    2016-02-01

    The Advanced Breast Cancer Third International Consensus Conference on the diagnosis and treatment of advanced breast cancer took place in Lisbon, Portugal, on November 5-7, 2015. This year's conference (ABC3) was focused on the treatment of metastatic breast cancer (stage IV), as it was 4 years ago at the first consensus meeting (ABC1). A matter of particular interest was the patients' perspective. Thus, patient-relevant issues were addressed by the consensus discussions, such as those on treatment goals, quality of life, care of long-term survivors ('survivorship issues'), and coping with disease-related symptoms and the side effects of treatment. Further important issues on the agenda were the use of standardized instruments for the assessment of individual treatment success ('patient-reported outcome measures') and the evaluation of the benefit of novel drugs (e.g. the European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale). Diagnosis and treatment of inoperable locally advanced breast cancer had already been discussed 2 years earlier at the ABC2 Consensus and were not dealt with in the framework of this year's ABC3 Consensus. With regard to country-specific peculiarities, which unavoidably found their way into the ABC Consensus, a working group of German breast cancer experts commented on the voting results of the ABC panelists. As for the past consensus, the group specially considered the German guidelines for the diagnosis and treatment of breast cancer (AGO (Gyneco-Oncology Working Group), S3, DGHO (German Society of Hematology and Medical Oncology)) in order to adapt the ABC3 consensus for everyday therapy in Germany.

  19. Polymorphism in ABC transporter genes of Dirofilaria immitis.

    Science.gov (United States)

    Mani, Thangadurai; Bourguinat, Catherine; Prichard, Roger K

    2017-08-01

    Dirofilaria immitis, a filarial nematode, causes dirofilariasis in dogs, cats and occasionally in humans. Prevention of the disease has been mainly by monthly use of the macrocyclic lactone (ML) endectocides during the mosquito transmission season. Recently, ML resistance has been confirmed in D. immitis and therefore, there is a need to find new classes of anthelmintics. One of the mechanisms associated with ML resistance in nematodes has been the possible role of ATP binding cassette (ABC) transporters in reducing drug concentrations at receptor sites. ABC transporters, mainly from sub-families B, C and G, may contribute to multidrug resistance (MDR) by active efflux of drugs out of the cell. Gene products of ABC transporters may thus serve as the targets for agents that may modulate susceptibility to drugs, by inhibiting drug transport. ABC transporters are believed to be involved in a variety of physiological functions critical to the parasite, such as sterol transport, and therefore may also serve as the target for drugs that can act as anthelmintics on their own. Knowledge of polymorphism in these ABC transporter genes in nematode parasites could provide useful information for the process of drug design. We have identified 15 ABC transporter genes from sub-families A, B, C and G, in D. immitis, by comparative genomic approaches and analyzed them for polymorphism. Whole genome sequencing data from four ML susceptible (SUS) and four loss of efficacy (LOE) pooled populations were used for single nucleotide polymorphism (SNP) genotyping. Out of 231 SNPs identified in those 15 ABC transporter genes, 89 and 75 of them were specific to the SUS or LOE populations, respectively. A few of the SNPs identified may affect gene expression, protein function, substrate specificity or resistance development and may be useful for transporter inhibitor/anthelmintic drug design, or in order to anticipate resistance development. Copyright © 2017 The Authors. Published by

  20. "ABC's Earthquake" (Experiments and models in seismology)

    Science.gov (United States)

    Almeida, Ana

    2017-04-01

    Ana Almeida, Portugal Almeida, Ana Escola Básica e Secundária Dr. Vieira de Carvalho Moreira da Maia, Portugal The purpose of this presentation, in poster format, is to disclose an activity which was planned and made by me, in a school on the north of Portugal, using a kit of materials simple and easy to use - the sismo-box. The activity "ABC's Earthquake" was developed under the discipline of Natural Sciences, with students from 7th grade, geosciences teachers and other areas. The possibility of work with the sismo-box was seen as an exciting and promising opportunity to promote science, seismology more specifically, to do science, when using the existing models in the box and with them implement the scientific method, to work and consolidate content and skills in the area of Natural Sciences, to have a time of sharing these materials with classmates, and also with other teachers from the different areas. Throughout the development of the activity, either with students or teachers, it was possible to see the admiration by the models presented in the earthquake-box, as well as, the interest and the enthusiasm in wanting to move and understand what the results after the proposed procedure in the script. With this activity, we managed to promote: - educational success in this subject; a "school culture" with active participation, with quality, rules, discipline and citizenship values; fully integration of students with special educational needs; strengthen the performance of the school as a cultural, informational and formation institution; provide activities to date and innovative; foment knowledge "to be, being and doing" and contribute to a moment of joy and discovery.Learn by doing!

  1. Analytical Tools for Functional Assessment of Architectural Layouts

    Science.gov (United States)

    Bąkowski, Jarosław

    2017-10-01

    Functional layout of the building, understood as a layout or set of the facility rooms (or groups of rooms) with a system of internal communication, creates an environment and a place of mutual relations between the occupants of the object. Achieving optimal (from the occupants’ point of view) spatial arrangement is possible through activities that often go beyond the stage of architectural design. Adopted in the architectural design, most often during trial and error process or on the basis of previous experience (evidence-based design), functional layout is subject to continuous evaluation and dynamic changing since the beginning of its use. Such verification of the occupancy phase allows to plan future, possible transformations, as well as to develop model solutions for use in other settings. In broader terms, the research hypothesis is to examine whether and how the collected datasets concerning the facility and its utilization can be used to develop methods for assessing functional layout of buildings. In other words, if it is possible to develop an objective method of assessing functional layouts basing on a set of buildings’ parameters: technical, technological and functional ones and whether the method allows developing a set of tools enhancing the design methodology of complex functional objects. By linking the design with the construction phase it is possible to build parametric models of functional layouts, especially in the context of sustainable design or lean design in every aspect: ecological (by reducing the property’s impact on environment), economic (by optimizing its cost) and social (through the implementation of high-performance work environment). Parameterization of size and functional connections of the facility become part of the analyses, as well as the element of model solutions. The “lean” approach means the process of analysis of the existing scheme and consequently - finding weak points as well as means for eliminating these

  2. Comparison of mechanistic transport cycle models of ABC exporters.

    Science.gov (United States)

    Szöllősi, Dániel; Rose-Sperling, Dania; Hellmich, Ute A; Stockner, Thomas

    2018-04-01

    ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out essential substrate transport reactions across cell membranes. Their transmembrane domains bind and translocate substrates and are connected to a pair of nucleotide binding domains, which bind and hydrolyze ATP to energize import or export of substrates. Over four decades of investigations into ABC transporters have revealed numerous details from atomic-level structural insights to their functional and physiological roles. Despite all these advances, a comprehensive understanding of the mechanistic principles of ABC transporter function remains elusive. The human multidrug resistance transporter ABCB1, also referred to as P-glycoprotein (P-gp), is one of the most intensively studied ABC exporters. Using ABCB1 as the reference point, we aim to compare the dominating mechanistic models of substrate transport and ATP hydrolysis for ABC exporters and to highlight the experimental and computational evidence in their support. In particular, we point out in silico studies that enhance and complement available biochemical data. "This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin McIlwain." Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  3. The Arabidopsis thaliana ABC protein superfamily, a complete inventory.

    Science.gov (United States)

    Sánchez-Fernández, R; Davies, T G; Coleman, J O; Rea, P A

    2001-08-10

    We describe the first complete inventory of ATP-binding cassette (ABC) proteins from a multicellular organism, the model plant Arabidopsis thaliana. By the application of several search criteria, Arabidopsis was found to contain a total of 129 open reading frames (ORFs) capable of encoding ABC proteins, of which 103 possessed contiguous transmembrane spans and were identified as putative intrinsic membrane proteins. Fifty-two of the putative intrinsic membrane proteins contained at least two transmembrane domains (TMDs) and two nucleotide-binding folds (NBFs) and could be classified as belonging to one of five subfamilies of full-molecule transporters. The other 51 putative membrane proteins, all of which were half-molecule transporters, fell into five subfamilies. Of the remaining ORFs identified, all of which encoded proteins lacking TMDs, 11 could be classified into three subfamilies. There were no obvious homologs in other organisms for 15 of the ORFs which encoded a heterogeneous group of non-intrinsic ABC proteins (NAPs). Unrooted phylogenetic analyses substantiated the subfamily designations. Notable features of the Arabidopsis ABC superfamily was the presence of a large yeast-like PDR subfamily, and the absence of genes encoding bona fide cystic fibrosis transmembrane conductance regulator (CFTR), sulfonylurea receptor (SUR), and heavy metal tolerance factor 1 (HMT1) homologs. Arabidopsis was unusual in its large allocation of ORFs (a minimum of 0.5%) to members of the ABC protein superfamily.

  4. Asymmetric switching in a homodimeric ABC transporter: a simulation study.

    Directory of Open Access Journals (Sweden)

    Jussi Aittoniemi

    2010-04-01

    Full Text Available ABC transporters are a large family of membrane proteins involved in a variety of cellular processes, including multidrug and tumor resistance and ion channel regulation. Advances in the structural and functional understanding of ABC transporters have revealed that hydrolysis at the two canonical nucleotide-binding sites (NBSs is co-operative and non-simultaneous. A conserved core architecture of bacterial and eukaryotic ABC exporters has been established, as exemplified by the crystal structure of the homodimeric multidrug exporter Sav1866. Currently, it is unclear how sequential ATP hydrolysis arises in a symmetric homodimeric transporter, since it implies at least transient asymmetry at the NBSs. We show by molecular dynamics simulation that the initially symmetric structure of Sav1866 readily undergoes asymmetric transitions at its NBSs in a pre-hydrolytic nucleotide configuration. MgATP-binding residues and a network of charged residues at the dimer interface are shown to form a sequence of putative molecular switches that allow ATP hydrolysis only at one NBS. We extend our findings to eukaryotic ABC exporters which often consist of two non-identical half-transporters, frequently with degeneracy substitutions at one of their two NBSs. Interestingly, many residues involved in asymmetric conformational switching in Sav1866 are substituted in degenerate eukaryotic NBS. This finding strengthens recent suggestions that the interplay of a consensus and a degenerate NBS in eukaroytic ABC proteins pre-determines the sequence of hydrolysis at the two NBSs.

  5. Wisconsin River at Portage, Wisconsin; Feasibility Study for Flood Control Plant of Study.

    Science.gov (United States)

    1977-08-01

    natural setting that the late Aldo Leopold , often called the "Father of Wildlife Management," wrote some of his famous works in the still-standing log...Protect endangered or threatened plants and animals and their ha>itats. e. Consider the Aldo Leopold Memorial Reserve. The Wisconsin Department of Natural...standing log cabin he built -- that the late 0 0 Aldo Leopold wrote some of his famous works. He also wrote about this very site and the immediate area

  6. An evaluation of the bedrock aquifer system in northeastern Wisconsin

    Science.gov (United States)

    Emmons, P.J.

    1987-01-01

    Ground water is a major source of water in northeastern Wisconsin. The lower Fox River valley, located between Lake Winnebago and Green Bay in northeastern Wisconsin, is the second largest population center in Wisconsin. By 1957, ground-water withdrawals had lowered the potentiometric surface of the aquifer system as much as 440 feet below prepumping levels. With the exception of the city of Green Bay, which converted from ground water to surface water (Lake Michigan) for their municipal water supply in 1957, ground-water withdrawals have continually increased.

  7. Survey of medical radium installations in Wisconsin

    International Nuclear Information System (INIS)

    Tapert, A.C.; Lea, W.L.

    1975-05-01

    A radiation protection survey was performed at 70 medical radium installations in the State of Wisconsin. The requirements of the State's Radiation Protection Code were used as survey criteria. Radiation measurements of radium storage containers, radium capsule leakage tests, and monitoring of work surfaces for contamination were performed. Film badge monitoring data of whole body and extremity doses are presented for 221 individuals at 17 hospitals. Whole body doses during single treatments ranged from 10 to 1360 mrems per individual. The estimate of 500 mrems per treatment was determined as the dose aggregate to hospital personnel. Whole body doses from film badges are compared with analogous TLD doses. Four physicians and six technicians at nine hospitals participated in a study for monitoring the extremities with TLD. Cumulative extremity doses ranged from 28 to 6628 mrems per participant during the study. (U.S.)

  8. US hydropower resource assessment for Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Conner, A.M.; Francfort, J.E.

    1996-05-01

    The Department of Energy is developing an estimate of the undeveloped hydropower potential in this country. The Hydropower Evaluation Software is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The software measures the undeveloped hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven software program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the State of Wisconsin.

  9. Second-order nonlinear optical metamaterials: ABC-type nanolaminates

    International Nuclear Information System (INIS)

    Alloatti, L.; Kieninger, C.; Lauermann, M.; Köhnle, K.; Froelich, A.; Wegener, M.; Frenzel, T.; Freude, W.; Leuthold, J.; Koos, C.

    2015-01-01

    We demonstrate a concept for second-order nonlinear metamaterials that can be obtained from non-metallic centrosymmetric constituents with inherently low optical absorption. The concept is based on iterative atomic-layer deposition of three different materials, A = Al 2 O 3 , B = TiO 2 , and C = HfO 2 . The centrosymmetry of the resulting ABC stack is broken since the ABC and the inverted CBA sequences are not equivalent—a necessary condition for non-zero second-order nonlinearity. In our experiments, we find that the bulk second-order nonlinear susceptibility depends on the density of interfaces, leading to a nonlinear susceptibility of 0.26 pm/V at a wavelength of 800 nm. ABC-type nanolaminates can be deposited on virtually any substrate and offer a promising route towards engineering of second-order optical nonlinearities at both infrared and visible wavelengths

  10. Functional analysis of candidate ABC transporter proteins for sitosterol transport

    DEFF Research Database (Denmark)

    Albrecht, C; Elliott, J I; Sardini, A

    2002-01-01

    Two ATP-binding cassette (ABC) proteins, ABCG5 and ABCG8, have recently been associated with the accumulation of dietary cholesterol in the sterol storage disease sitosterolemia. These two 'half-transporters' are assumed to dimerize to form the complete sitosterol transporter which reduces...... the absorption of sitosterol and related molecules in the intestine by pumping them back into the lumen. Although mutations altering ABCG5 and ABCG8 are found in affected patients, no functional demonstration of sitosterol transport has been achieved. In this study, we investigated whether other ABC transporters......-specific ABC transporters have acquired specificity to exclude sitosterol and related sterols like cholesterol presumably because the abundance of cholesterol in the membrane would interfere with their action; in consequence, specific transporters have evolved to handle these sterols....

  11. Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance

    Directory of Open Access Journals (Sweden)

    Rebecca Clemens

    2018-01-01

    Full Text Available Antimicrobial peptides, which contain (methyl-lanthionine-rings are called lantibiotics. They are produced by several Gram-positive bacteria and are mainly active against these bacteria. Although these are highly potent antimicrobials, some human pathogenic bacteria express specific ABC transporters that confer resistance and counteract their antimicrobial activity. Two distinct ABC transporter families are known to be involved in this process. These are the Cpr- and Bce-type ABC transporter families, named after their involvement in cationic peptide resistance in Clostridium difficile, and bacitracin efflux in Bacillus subtilis, respectively. Both resistance systems differentiate to each other in terms of the proteins involved. Here, we summarize the current knowledge and describe the divergence as well as the common features present in both the systems to confer lantibiotic resistance.

  12. Updating progress in cancer control in Wisconsin.

    Science.gov (United States)

    Treml, Kimberly B; McElroy, Jane A; Kaufman, Stephanie K; Remington, Patrick L; Wegner, Mark V

    2006-06-01

    In 1989, experts in cancer prevention, early detection, and treatment met in Madison to set the public health agenda for cancer control. Part of the plan defined target percent change in cancer mortality rates to be met by the year 2000. During the 1990s, public health and health care professionals developed programs and policies to reach these goals. The purpose of this analysis is to evaluate Wisconsin's progress in reducing cancer mortality and success in meeting the year 2000 objectives. Wisconsin mortality data for 1984-1986 and 1999-2001 were obtained from the Centers for Disease Control and Prevention, CDC Wonder. Percent change was calculated between the 2 time periods and compared to the 2000 target percent change for all-site cancer and site specific cancer mortality. All-site cancer mortality decreased by 7% from 1984-1986 to 1999-2001 with a greater than 16% decline in age groups <65 years. Mortality from breast, colorectal, and cervical cancer each decreased by at least 25%. Lung cancer and malignant melanoma mortality rates increased by 5% and 17%, respectively. Among additionally analyzed cancers, mortality decreased in prostate, stomach, and childhood cancers and increased in liver cancer and non-Hodgkin's lymphoma. The results of the state's cancer control effort are mixed. The year 2000 objectives were met for breast and colorectal cancer. Progress was made in reducing mortality from cervical cancer and from all sites combined, but the other year 2000 objectives were not met. Mortality rates increased for lung cancer and malignant melanoma during the 15-year period.

  13. Laboratory investigation of grouted coupler connection details for ABC bridge projects.

    Science.gov (United States)

    2015-08-01

    With an ever increasing desire to utilize accelerated bridge construction (ABC) techniques, it is becoming critical that bridge : designers and contractors have confidence in typical details. The Keg Creek Bridge on US 6 in Iowa was a recent ABC exam...

  14. Effects of Optimizing the Scan-Path on Scanning Keyboards with QWERTY-Layout for English Text.

    Science.gov (United States)

    Sandnes, Frode Eika; Medola, Fausto Orsi

    2017-01-01

    Scanning keyboards can be essential tools for individuals with reduced motor function. However, most research addresses layout optimization. Learning new layouts is time-consuming. This study explores the familiar QWERTY layout with alternative scanning paths intended for English text. The results show that carefully designed scan-paths can help QWERTY nearly match optimized layouts in performance.

  15. Playware ABC 2: a Disruptive Technology for Global Development

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2017-01-01

    The Playware ABC concept is used to create solutions that are usable by all kinds of users and contexts in our globalized society. In this paper, the Playware ABC can be exemplified with the development of the modular interactive tiles for health prevention and rehabilitation of anybody, anywhere......, anytime. The paper gives examples of how playware becomes a disruptive technology for global development, for instance in the health sector. For instance, in Tanzania doctors and community-based rehabilitation workers are constructing and combining modular playware tiles to easily create the right kind...

  16. Sistema de costos ABC, en la mediana empresa industrial mexicana

    OpenAIRE

    López-Mejía, María Rosa; Universidad Autónoma de Puebla; Gómez-Martínez, Alicia; Universidad Autónoma de Puebla; Marín-Hernández, Salvador; Universidad de Murcia

    2011-01-01

    La gestión de costos en las empresas es un tema relevante en el ámbito de fuerte competencia de los mercados globales. En aras de mejorar su eficiencia, algunas compañías han adoptado el Sistema de Costos Basado en Actividades (ABC). Por tal motivo, el objetivo de este trabajo es analizar, en la práctica, por qué una empresa ha adoptado el ABC. La investigación se realizó con una empresa mediana industrial de Puebla, México, a la cual se le aplicó un estudio de caso y se buscó conocer: los mo...

  17. Costs equations for cost modeling: application of ABC Matrix

    Directory of Open Access Journals (Sweden)

    Alex Fabiano Bertollo Santana

    2016-03-01

    Full Text Available This article aimed at providing an application of the ABC Matrix model - a management tool that models processes and activities. The ABC Matrix is based on matrix multiplication, using a fast algorithm for the development of costing systems and the subsequent translation of the costs in cost equations and systems. The research methodology is classified as a case study, using the simulation data to validate the model. The conclusion of the research is that the algorithm presented is an important development, because it is an effective approach to calculating the product cost and because it provides simple and flexible algorithm design software for controlling the cost of products

  18. [Land layout for lake tourism based on ecological restraint].

    Science.gov (United States)

    Wang, Jian-Ying; Li, Jiang-Feng; Zou, Li-Lin; Liu, Shi-Bin

    2012-10-01

    To avoid the decrease and deterioration of lake wetlands and the other ecological issues such as lake water pollution that were caused by the unreasonable exploration of lake tourism, a land layout for the tourism development of Liangzi Lake with the priority of ecological security pattern was proposed, based on the minimal cumulative resistance model and by using GIS technology. The study area was divided into four ecological function zones, i. e., core protection zone, ecological buffer zone, ecotone zone, and human activity zone. The core protection zone was the landscape region of ecological source. In the protection zone, new tourism land was forbidden to be increased, and some of the existing fundamental tourism facilities should be removed while some of them should be upgraded. The ecological buffer zone was the landscape region with resistance value ranged from 0 to 4562. In the buffer zone, expansion of tourism land should be forbidden, the existing tourism land should be downsized, and human activities should be isolated from ecological source by converting the human environment to the natural environment as far as possible. The ecotone zone was the landscape region with resistance value ranged from 4562 to 30797. In this zone, the existing tourism land was distributed in patches, tourism land could be expanded properly, and the lake forestry ecological tourism should be developed widely. The human activity zone was the landscape region with resistance value ranged from 30797 to 97334, which would be the key area for the land layout of lake tourism. It was suggested that the land layout for tourism with the priority of landscape ecological security pattern would be the best choice for the lake sustainable development.

  19. Wendelstein 7-X Torus Hall Layout and System Integration

    International Nuclear Information System (INIS)

    Hartmann, D.; Damiani, C.; Hartfuss, H.-J.; Krampitz, R.; Neuner, U.

    2006-01-01

    Wendelstein 7-X is an experimental fusion device presently under construction in Greifswald, Germany, to study the stellarator concept at reactor relevant parameters und steady-state conditions. The heart of the machine consists of the torus that houses the superconducting coils and the plasma vacuum vessel. It is located nearly in the center of a 30 m x 30 m x 20 m hall. A large number of components need to be placed in close proximity of the torus to provide the system with the required means, e.g. cryogenic gases, cooling water, electricity, and to integrate it with the peripheral diagnostic and heating components. The arrangement of these components has to be supported by suitable structures, and has to be optimized to allow for installation, maintenance, and repair. In addition, space has to be provided for escape routes and for sufficient distance between components that could negatively influence each other's performance, etc. The layout of the components has been done over many years using 3D CAD software. It was based on simple geometric models of the components and of the additionally required space. Presently the layout design is being detailed and updated by replacing the original coarse models with more refined estimates or - in some cases - with as-built models. All interface requirements are carefully taken into account. Detailed routing was specified for the cryo and cooling water supply lines whose design and installation is outsourced. Due to the limited space available and severely restricted access during experimental campaigns, the requirement to put auxiliary components like electronic racks into the torus hall is being queried. The paper summarizes the present state of the component layout in the torus hall, and how the peripheral supply, diagnostics, and heating systems are integrated into the machine. (author)

  20. High-Quality Ultra-Compact Grid Layout of Grouped Networks.

    Science.gov (United States)

    Yoghourdjian, Vahan; Dwyer, Tim; Gange, Graeme; Kieffer, Steve; Klein, Karsten; Marriott, Kim

    2016-01-01

    Prior research into network layout has focused on fast heuristic techniques for layout of large networks, or complex multi-stage pipelines for higher quality layout of small graphs. Improvements to these pipeline techniques, especially for orthogonal-style layout, are difficult and practical results have been slight in recent years. Yet, as discussed in this paper, there remain significant issues in the quality of the layouts produced by these techniques, even for quite small networks. This is especially true when layout with additional grouping constraints is required. The first contribution of this paper is to investigate an ultra-compact, grid-like network layout aesthetic that is motivated by the grid arrangements that are used almost universally by designers in typographical layout. Since the time when these heuristic and pipeline-based graph-layout methods were conceived, generic technologies (MIP, CP and SAT) for solving combinatorial and mixed-integer optimization problems have improved massively. The second contribution of this paper is to reassess whether these techniques can be used for high-quality layout of small graphs. While they are fast enough for graphs of up to 50 nodes we found these methods do not scale up. Our third contribution is a large-neighborhood search meta-heuristic approach that is scalable to larger networks.

  1. Comparative study T-type and I-type layout of PWR nuclear power plants

    International Nuclear Information System (INIS)

    Eko Rudi Iswanto and Siti Alimah

    2010-01-01

    Determining plant layout is one of the five major stages during the life time of a nuclear power plant. Some important factors that affect in the selecting of plant layout are availability of infrastructure, economic aspects, social aspects, public and environment safety, and also easy to do. Another factor to be considered is requirements as seismic design, which refers to the principles of good security workers, communities and the environment of radiological risks. There are many layout types of nuclear power plant, two of them are T-type layout and I-type layout. Each type of the plant layout has advantage and disadvantage, therefore this study is to understand them. Good layout is able to provide a high level of security against earthquakes. In term of earthquake design, I-type layout has a higher security level than T-type layout. Therefore, I-type layout can be a good choice for PWR nuclear power plants 1000 MWe that will be built in Indonesia. (author)

  2. Silicon drift detector: device design and mask layout

    International Nuclear Information System (INIS)

    Mehta, Pourus; Mishra, Vijay; Kataria, S.K.; Rao, Ramgopal

    2005-01-01

    The mask design of Silicon Drift Detector (SDD) to be fabricated at the fabrication lab of IIT Bombay has been done. The mask layout consists of 13 distinct designs of varying geometry and design parameters. The design rules related to the silicon fabrication facility at IITB have been strictly adhered to while designing the mask for SDD. Additional features like alignment marks, reference marks and scribe lines have also been incorporated to facilitate convenient fabrication and ease in dicing of devices after processing. The next step is to get the mask set fabricated commercially and subsequently proceed towards SDD fabrication. (author)

  3. A new dynamical layout algorithm for complex biochemical reaction networks.

    Science.gov (United States)

    Wegner, Katja; Kummer, Ursula

    2005-08-26

    To study complex biochemical reaction networks in living cells researchers more and more rely on databases and computational methods. In order to facilitate computational approaches, visualisation techniques are highly important. Biochemical reaction networks, e.g. metabolic pathways are often depicted as graphs and these graphs should be drawn dynamically to provide flexibility in the context of different data. Conventional layout algorithms are not sufficient for every kind of pathway in biochemical research. This is mainly due to certain conventions to which biochemists/biologists are used to and which are not in accordance to conventional layout algorithms. A number of approaches has been developed to improve this situation. Some of these are used in the context of biochemical databases and make more or less use of the information in these databases to aid the layout process. However, visualisation becomes also more and more important in modelling and simulation tools which mostly do not offer additional connections to databases. Therefore, layout algorithms used in these tools have to work independently of any databases. In addition, all of the existing algorithms face some limitations with respect to the number of edge crossings when it comes to larger biochemical systems due to the interconnectivity of these. Last but not least, in some cases, biochemical conventions are not met properly. Out of these reasons we have developed a new algorithm which tackles these problems by reducing the number of edge crossings in complex systems, taking further biological conventions into account to identify and visualise cycles. Furthermore the algorithm is independent from database information in order to be easily adopted in any application. It can also be tested as part of the SimWiz package (free to download for academic users at 1). The new algorithm reduces the complexity of pathways, as well as edge crossings and edge length in the resulting graphical representation

  4. A new dynamical layout algorithm for complex biochemical reaction networks

    Directory of Open Access Journals (Sweden)

    Kummer Ursula

    2005-08-01

    Full Text Available Abstract Background To study complex biochemical reaction networks in living cells researchers more and more rely on databases and computational methods. In order to facilitate computational approaches, visualisation techniques are highly important. Biochemical reaction networks, e.g. metabolic pathways are often depicted as graphs and these graphs should be drawn dynamically to provide flexibility in the context of different data. Conventional layout algorithms are not sufficient for every kind of pathway in biochemical research. This is mainly due to certain conventions to which biochemists/biologists are used to and which are not in accordance to conventional layout algorithms. A number of approaches has been developed to improve this situation. Some of these are used in the context of biochemical databases and make more or less use of the information in these databases to aid the layout process. However, visualisation becomes also more and more important in modelling and simulation tools which mostly do not offer additional connections to databases. Therefore, layout algorithms used in these tools have to work independently of any databases. In addition, all of the existing algorithms face some limitations with respect to the number of edge crossings when it comes to larger biochemical systems due to the interconnectivity of these. Last but not least, in some cases, biochemical conventions are not met properly. Results Out of these reasons we have developed a new algorithm which tackles these problems by reducing the number of edge crossings in complex systems, taking further biological conventions into account to identify and visualise cycles. Furthermore the algorithm is independent from database information in order to be easily adopted in any application. It can also be tested as part of the SimWiz package (free to download for academic users at 1. Conclusion The new algorithm reduces the complexity of pathways, as well as edge crossings

  5. Energy efficient LED layout optimization for near-uniform illumination

    Science.gov (United States)

    Ali, Ramy E.; Elgala, Hany

    2016-09-01

    In this paper, we consider the problem of designing energy efficient light emitting diodes (LEDs) layout while satisfying the illumination constraints. Towards this objective, we present a simple approach to the illumination design problem based on the concept of the virtual LED. We formulate a constrained optimization problem for minimizing the power consumption while maintaining a near-uniform illumination throughout the room. By solving the resulting constrained linear program, we obtain the number of required LEDs and the optimal output luminous intensities that achieve the desired illumination constraints.

  6. Layout for Assessing Dynamic Posture: Development, Validation, and Reproducibility.

    Science.gov (United States)

    Noll, Matias; Candotti, Cláudia Tarragô; da Rosa, Bruna Nichele; Sedrez, Juliana Adami; Vieira, Adriane; Loss, Jefferson Fagundes

    2016-01-01

    To determine the psychometric properties of the layout for assessing dynamic posture (LADy). The study was divided into 2 phases: (1) development of the instrument and (2) determination of validity and reproducibility. The LADy was designed to evaluate the position adopted in 9 dynamic postures. The results confirmed the validity and reproducibility of the instrument. From a total of 51 criteria assessing 9 postures, 1 was rejected. The reproducibility for each of the criteria was classified as moderate to excellent. The LADy constitutes a valid and reproducible instrument for the evaluation of dynamic postures in children 11 to 17 years old. It is low cost and applicable in the school environment.

  7. Wind conditions in urban layout - Numerical and experimental research

    Science.gov (United States)

    Poćwierz, Marta; Zielonko-Jung, Katarzyna

    2018-01-01

    This paper presents research which compares the numerical and the experimental results for different cases of airflow around a few urban layouts. The study is concerned mostly with the analysis of parameters, such as pressure and velocity fields, which are essential in the building industry. Numerical simulations have been performed by the commercial software Fluent, with the use of a few different turbulence models, including popular k-ɛ, k-ɛ realizable or k-ω. A particular attention has been paid to accurate description of the conditions on the inlet and the selection of suitable computing grid. The pressure measurement near buildings and oil visualization were undertaken and described accordingly.

  8. DESIGNING OF TOWN SKYLINE ON THE STAGE OF GENERAL LAYOUT

    Directory of Open Access Journals (Sweden)

    Yu. N. Kishik

    2007-01-01

    Full Text Available It is proposed to consider an aggregation of such active elements of town structure as multistoreyed dominants to be used as a basis for designing skyline of a large town on the stage of its general layout. Some interrelated principles, namely: spatial integration, subordination, nature consistence, succession are formulated for improvement of their spatial organization. Every principle takes down any general property of the network of vertical accents which is formed as a system. The obtained principles of the system organization of the multistoreyed dominants are checked while designing Grodno skyline. 

  9. University of Wisconsin Antarctic Soils Database, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The University of Wisconsin Antarctic Soils Database contains data collected by Dr. James G. Bockheim and his colleagues from 1975 through 1987. Data include site...

  10. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.

    Science.gov (United States)

    Mendoza-Cózatl, David G; Zhai, Zhiyang; Jobe, Timothy O; Akmakjian, Garo Z; Song, Won-Yong; Limbo, Oliver; Russell, Matthew R; Kozlovskyy, Volodymyr I; Martinoia, Enrico; Vatamaniuk, Olena K; Russell, Paul; Schroeder, Julian I

    2010-12-24

    Phytochelatins mediate tolerance to heavy metals in plants and some fungi by sequestering phytochelatin-metal complexes into vacuoles. To date, only Schizosaccharomyces pombe Hmt1 has been described as a phytochelatin transporter and attempts to identify orthologous phytochelatin transporters in plants and other organisms have failed. Furthermore, recent data indicate that the hmt1 mutant accumulates significant phytochelatin levels in vacuoles, suggesting that unidentified phytochelatin transporters exist in fungi. Here, we show that deletion of all vacuolar ABC transporters abolishes phytochelatin accumulation in S. pombe vacuoles and abrogates (35)S-PC(2) uptake into S. pombe microsomal vesicles. Systematic analysis of the entire S. pombe ABC transporter family identified Abc2 as a full-size ABC transporter (ABCC-type) that mediates phytochelatin transport into vacuoles. The S. pombe abc1 abc2 abc3 abc4 hmt1 quintuple and abc2 hmt1 double mutant show no detectable phytochelatins in vacuoles. Abc2 expression restores phytochelatin accumulation into vacuoles and suppresses the cadmium sensitivity of the abc quintuple mutant. A novel, unexpected, function of Hmt1 in GS-conjugate transport is also shown. In contrast to Hmt1, Abc2 orthologs are widely distributed among kingdoms and are proposed as the long-sought vacuolar phytochelatin transporters in plants and other organisms.

  11. The Assessment of Burden of COPD (ABC) Scale : A Reliable and Valid Questionnaire

    NARCIS (Netherlands)

    Slok, Annerika H. M.; Bemelmans, Thomas C. H.; Kotz, Daniel; van der Molen, Thys; Kerstjens, Huib A. M.; in 't Veen, Johannes C. C. M.; Chavannes, Niels H.; Asijee, Guus M.; Rutten-van Molken, Maureen P. M. H.; van Schayck, Onno C. P.

    2016-01-01

    The newly developed Assessment of Burden of COPD (ABC) scale is a 14-item self-administered questionnaire which measures the physical, psychological, emotional and/or social burden as experienced by patients with chronic obstructive pulmonary disease (COPD). The ABC scale is part of the ABC tool

  12. Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays

    NARCIS (Netherlands)

    Krumpochova, Petra; Sapthu, Sunny; Brouwers, Jos F.; de Haas, Marcel; de Vos, Ric; Borst, Piet; van de Wetering, Koen

    2012-01-01

    The ATP-binding cassette (ABC) genes encode the largest family of transmembrane proteins. ABC transporters translocate a wide variety of substrates across membranes, but their physiological function is often incompletely understood. We describe a new method to study the substrate spectrum of ABC

  13. Geographic and racial variation in teen pregnancy rates in Wisconsin.

    Science.gov (United States)

    Layde, Molly M; Remington, Patrick L

    2013-08-01

    Despite recent declines in teen birth rates, teenage pregnancy remains an important public health problem in Wisconsin with significant social, economic, and health-related effects. Compare and contrast teen birth rate trends by race, ethnicity, and county in Wisconsin. Teen (ages 15-19 years) birth rates (per 1000 teenage females) in Wisconsin from 2001-2010 were compared by racelethnicity and county of residence using data from the Wisconsin Interactive Statistics on Health. Teen birth rates in Wisconsin have declined by 20% over the past decade, from 35.5/1000 teens in 2001 to 28.3/1000 teens in 2010-a relative decline of 20.3%. However, trends vary by race, with declines among blacks (-33%) and whites (-26%) and increases among American Indians (+21%) and Hispanics (+30%). Minority teen birth rates continue to be 3 to 5 times greater than birth rates among whites. Rates varied even more by county, with an over 14-fold difference between Ozaukee County (7.8/1000) and Menominee County (114.2). Despite recent declines, teen pregnancy continues to be an important public health problem in Wisconsin. Pregnancy prevention programs should be targeted toward the populations and counties with the highest rates.

  14. Layout of a cross-shaped inner tracker

    CERN Document Server

    Steinkamp, O

    2001-01-01

    The LHCb Technical Proposal described a tracking system in which the Inner Tracker covered a rectangular surface of 60\\,cm$\\times$40\\,cm around the beampipe. In the meantime, simulation studies have shown that the borderline between Inner and Outer Trackers has to be shifted further away from the beampipe in order to obtain acceptably low occupancies in the innermost regions of the Outer Tracker. In an effort to keep the surface covered by the relatively expensive Inner Tracker technology as small as possible, a new layout of the tracking stations has been proposed, in which the Inner Tracker covers a cross-shaped area around the beampipe. The layout described in LHCb note 2000-107, in which each Inner Tracker station consisted of two "L"-shaped detector boxes, would not be well suited to cover such a cross-shaped area. A more elegant solution is proposed here, in which each Inner Tracker station consists of four rectangular detector boxes, one above, one below and one on each side of the beampipe.

  15. Neonatal Intensive Care Unit Layout and Nurses' Work.

    Science.gov (United States)

    Doede, Megan; Trinkoff, Alison M; Gurses, Ayse P

    2018-01-01

    Neonatal intensive care units (NICUs) remain one of the few areas in hospitals that still use an open bay (OPBY) design for patient stays greater than 24 hr, housing multiple infants, staff, and families in one large room. This creates high noise levels, contributes to the spread of infection, and affords families little privacy. These problems have given rise to the single-family room NICU. This represents a significant change in the care environment for nurses. This literature review answers the question: When compared to OPBY layout, how does a single family room layout impact neonatal nurses' work? Thirteen studies published between 2006 and 2015 were located. Many studies reported both positive and negative effects on nurses' work and were therefore sorted by their cited advantages and disadvantages. Advantages included improved quality of the physical environment; improved quality of patient care; improved parent interaction; and improvements in nurse job satisfaction, stress, and burnout. Disadvantages included decreased interaction among the NICU patient care team, increased nurse workload, decreased visibility on the unit, and difficult interactions with family. This review suggests that single-family room NICUs introduce a complex situation in which trade-offs occur for nurses, most prominently the trade-off between visibility and privacy. Additionally, the literature is clear on what elements of nurses' work are impacted, but how the built environment influences these elements, and how these elements interact during nurses' work, is not as well understood. The current level of research and directions for future research are also discussed.

  16. Aircraft Cockpit Ergonomic Layout Evaluation Based on Uncertain Linguistic Multiattribute Decision Making

    Directory of Open Access Journals (Sweden)

    Junxuan Chen

    2014-03-01

    Full Text Available In the view of the current cockpit information interaction, facilities and other characteristics are increasingly multifarious; the early layout evaluation methods based on single or partial components, often cause comprehensive evaluation unilateral, leading to the problems of long development period and low efficiency. Considering the fuzziness of ergonomic evaluation and diversity of evaluation information attributes, we refine and build an evaluation system based on the characteristics of the current cockpit man-machine layout and introduce the different types of uncertain linguistic multiple attribute combination decision making (DTULDM method in the cockpit layout evaluation process. Meanwhile, we also establish an aircraft cockpit ergonomic layout evaluation model. Finally, an experiment about cockpit layout evaluation is given, and the result demonstrates that the proposed method about cockpit ergonomic layout evaluation is feasible and effective.

  17. Accelerated bridge construction (ABC) decision making and economic modeling tool.

    Science.gov (United States)

    2011-12-01

    In this FHWA-sponsored pool funded study, a set of decision making tools, based on the Analytic Hierarchy Process (AHP) was developed. This tool set is prepared for transportation specialists and decision-makers to determine if ABC is more effective ...

  18. ABC transporter genes and risk of type 2 diabetes

    DEFF Research Database (Denmark)

    Schou, Jesper; Tybjærg-Hansen, Anne; Møller, Holger Jon

    2012-01-01

    Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2...... diabetes in the general population is unknown....

  19. Some observations on the comparative performance of two 3-ABC ...

    African Journals Online (AJOL)

    The performance of Chekit and Priocheck (Ceditest) 3-ABC ELISAs was evaluated in an area of endemicity using 196 sheep and 45 bovine sera. The Checkit ELISA failed to detect 8 positive sheep sera out of 10 detected by the Priocheck ELISA whilst both ELISAs detected 13 bovine sera as positive or borderline.

  20. The Reign of Confusion: ABC and the "Crisis in Iran."

    Science.gov (United States)

    Palmerton, Patricia R.

    A study examined reports broadcast by ABC News between November 8, 1979 and December 7, 1979 in its series entitled "Crisis in Iran: America Held Hostage." Transcripts of approximately 50% of actual broadcasts were subjected to rhetorical critical analysis, from which the finding emerged that confusion was the predominant characteristic…

  1. Selections from the ABC 2011 Annual Convention, Montreal, Canada

    Science.gov (United States)

    Whalen, D. Joel; Andersen, Ken; Campbell, Gloria; Crenshaw, Cheri; Cross, Geoffrey A.; Grinols, Anne Bradstreet; Hildebrand, John; Newman, Amy; Ortiz, Lorelei A.; Paulson, Edward; Phillabaum, Melinda; Powell, Elizabeth A.; Sloan, Ryan

    2012-01-01

    The 12 Favorite Assignments featured in this article were presented at the 2011 Annual Convention of the Association for Business Communication (ABC), Montreal, Canada. A variety of learning objectives are featured: delivering bad news, handling difficult people, persuasion, reporting financial analysis, electronic media, face-to-face…

  2. The ABCs for Pre-Service Teacher Cultural Competency Development

    Science.gov (United States)

    He, Ye; Cooper, Jewell E.

    2009-01-01

    In an effort to combine pre-service teachers' self-reflection with their field experiences to enhance their cultural competency, this study adopted Schmidt's ABC's (Autobiography, Biography, and Cross-cultural Comparison) Model in two courses in a pre-service teacher education program. Through group comparisons, this study measured the impact that…

  3. Selections from the ABC 2012 Annual Convention, Honolulu, Hawaii

    Science.gov (United States)

    Whalen, D. Joel

    2013-01-01

    The 13 Favorite Assignments featured here were presented at the 2012 Association for Business Communication (ABC) Annual Convention, Honolulu, Hawaii. A variety of learning objectives are featured, including the following: enhancing resume's visual impact, interpersonal skills, social media, team building, web design, community service projects,…

  4. The Value of Green Technology at ABC Community College

    Science.gov (United States)

    McAllister, Bernadette

    2012-01-01

    A challenge facing community colleges nationwide is to reduce the carbon footprint of campuses by initiating green technology initiatives. This case study assessed the effect of switching from paper assignments to a learning management system at ABC Community College. The topic is important because federal and state funding, as well as…

  5. Selections from the ABC 2009 Annual Convention, Portsmouth, Virginia

    Science.gov (United States)

    Whalen, D. Joel

    2010-01-01

    The "My Favorite Assignment" Session at the 2009 Association for Business Communication (ABC) annual convention in Portsmouth, Virginia, featured over a dozen teachers sharing pedagogical innovations in a fast-paced, 4-minute format designed by Dan Dietrich. The wide variety of ideas and techniques presented makes these sessions popular…

  6. ABC – Advocates for Breast Cancer | Steyn | South African Medical ...

    African Journals Online (AJOL)

    Early detection of breast cancer is imperative to improve survival rates. However, public awareness is lacking and healthcare facilities for the diagnosis and treatment of the disease, particularly in the public sector, are inadequate. A cancer alliance, Advocates for Breast Cancer (ABC), was formed in 2014 to campaign for a ...

  7. ABC implementation in the Nelson Mandela Bay Metropole: How far ...

    African Journals Online (AJOL)

    Activity-based costing (ABC) success factors have been studied in past research, mostly by using commonly known success factors. In this qualitative study, ... Extensive identifi cation of cost drivers is benefi cial to the extent where the product loses its relationship with the overhead cost. It is evident from this research that ...

  8. abc: An Extensible AspectJ Compiler

    DEFF Research Database (Denmark)

    Avgustinov, Pavel; Christensen, Aske Simon; Hendren, Laurie J.

    2006-01-01

    Research in the design of aspect-oriented programming languages requires a workbench that facilitates easy experimentation with new language features and implementation techniques. In particular, new features for AspectJ have been proposed that require extensions in many dimensions: syntax, type ...... design decisions. Finally, we review a few examples of projects by others that extend abc in interesting ways...

  9. Relationships Between the ABC Inventory and the Metropolitan Readiness Test

    Science.gov (United States)

    Van Horn, K. Roger; Holland, Jean M.

    1974-01-01

    The predictive validity and factor structure of the ABC Inventory were analyzed by comparing scores obtained by preschoolers on this test with scores on the Metropolitan Reading Test. The correlational and factor analyses results reveal significant empirical and conceptual relationships between the two tests. (Author/PC)

  10. ABC transporters of the wheat pathogen Mycosphaerella graminicola

    NARCIS (Netherlands)

    Zwiers, L.H.

    2002-01-01

    A TP- b inding c assette (ABC) transporters belong to one of the largest protein families known. They play a role in numerous vital processes in the cell and are characterised by their

  11. ABC transporters van Botrytis cinerea in biotische en abiotische interacties

    NARCIS (Netherlands)

    Schoonbeek, H.

    2005-01-01

    Op 29 november 2004 promoveerde Henk-jan Schoonbeek aan Wageningen Universiteit op het proefschrift getiteld 'ABC transporters from Botrytis cinerea in biotic and abiotic interactions'. Promotor was Prof. dr. ir. P.J.G.M. de Wit en co-promotor was dr.ir. M.A. de Waard, leerstoelgroep Fytopathologie,

  12. Dynamics of 'abc' and 'qd' constant parameters induction generator model

    DEFF Research Database (Denmark)

    Fajardo-R, L.A.; Medina, A.; Iov, F.

    2009-01-01

    In this paper, parametric sensibility effects on dynamics of the induction generator in the presence of local perturbations are investigated. The study is conducted in a 3x2 MW wind park dealing with abc, qd0 and qd reduced order, induction generator model respectively, and with fluxes as state...

  13. ABC transporters from Botrytis cinerea in biotic and abiotic interactions

    NARCIS (Netherlands)

    Schoonbeek, H.

    2004-01-01

    Botrytis cinereais the causal agent of grey mould disease on a wide variety of crop plants. It is relatively insensitive to natural and synthetic fungitoxic compounds. This thesis describes how ABC (ATP-binding cassette) transporters contribute to protection by actively

  14. Functional analysis of candidate ABC transporter proteins for sitosterol transport

    DEFF Research Database (Denmark)

    Albrecht, C; Elliott, J I; Sardini, A

    2002-01-01

    Two ATP-binding cassette (ABC) proteins, ABCG5 and ABCG8, have recently been associated with the accumulation of dietary cholesterol in the sterol storage disease sitosterolemia. These two 'half-transporters' are assumed to dimerize to form the complete sitosterol transporter which reduces the ab...

  15. Study on comprehensive evaluation model for nuclear power plant control room layout

    International Nuclear Information System (INIS)

    Zhu Yiming; Liu Yuan; Fan Huixian

    2010-01-01

    A comprehensive evaluation model for layout of the main control room of nuclear power plants was proposed. Firstly the design scope and principle for the layout of the main control room were defined based on the standards, and then the index system for the comprehensive evaluation was established. Finally, comprehensive evaluation was carried out for the layout design by applying the fuzzy comprehensive evaluation method in the index system. (authors)

  16. Evolutionary approach for spatial architecture layout design enhanced by an agent-based topology finding system

    Directory of Open Access Journals (Sweden)

    Zifeng Guo

    2017-03-01

    Full Text Available This paper presents a method for the automatic generation of a spatial architectural layout from a user-specified architectural program. The proposed approach binds a multi-agent topology finding system and an evolutionary optimization process. The former generates topology satisfied layouts for further optimization, while the latter focuses on refining the layouts to achieve predefined architectural criteria. The topology finding process narrows the search space and increases the performance in subsequent optimization. Results imply that the spatial layout modeling and the multi-floor topology are handled.

  17. Calculation of calibration factors and layout criteria for gamma scanning of waste drums from nuclear plants

    International Nuclear Information System (INIS)

    Inder Schmitten, W.; Sohnius, B.; Wehner, E.

    1990-01-01

    This paper present a procedure to calculate calibration factors for converting the measured gamma rate of waste drums into activity content and a layout and free release measurement criterion for waste drums. A computer program is developed that simulates drum scanning technique, which calculates calibration factors and eliminates laborious experimental measurements. The calculated calibration factors exhibit good agreement with experimentally determined values. By checking the calculated calibration factors for trial equipment layouts (including the waste drum and the scanning facility) using the layout and free release measurement criterion, a layout can be achieved that clearly determines whether there can be free release of a waste drum

  18. Wind farm layout optimization in complex terrain: A preliminary study on a Gaussian hill

    DEFF Research Database (Denmark)

    Feng, Ju; Shen, Wen Zhong

    2014-01-01

    One of the crucial problems for wind farm (WF) development is wind farm layout optimization. It seeks to find the optimal positions of wind turbines (WTs) inside a WF, so as to maximize and/or minimize a single objective or multiple objectives, while satisfying certain constraints. Although...... adaptive mechanisms and applied to solve the layout optimization problem of a WF on a Gaussian shape hill. The layout of the WF with a certain number of WTs is optimized to maximize the total power output, which obtained steady improvements over expert guess layouts....

  19. Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

    DEFF Research Database (Denmark)

    Clausen, Casper Hyttel; Skands, Gustav Erik; Bertelsen, Christian Vinther

    2015-01-01

    This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested...... and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 mu m beads from 1 mu m as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes...... of the new electrode layout. Good agreement was observed between the model and the obtained experimental results....

  20. The performance of the ATLAS initial detector layout for B-physics channels

    International Nuclear Information System (INIS)

    Epp, B.; Ghete, V.M.; Kuhn, D.; Zhang, Y.J.

    2004-01-01

    At the start-up of LHC one expects parts of the ATLAS detector to be missing. This layout is called initial layout, whereas the fully staged detector is called complete layout. B-physics channels were simulated, reconstructed and analyzed using the software tools of ATLAS data challenge-1 (DC1). The performance of the detector with respect to quantities relevant to the analysis of the B s → D s π channel and the validation of the full chain generation-simulation-reconstruction-analysis were evaluated for the initial and complete layout. (author)

  1. Impact of data layouts on the efficiency of GPU-accelerated IDW interpolation.

    Science.gov (United States)

    Mei, Gang; Tian, Hong

    2016-01-01

    This paper focuses on evaluating the impact of different data layouts on the computational efficiency of GPU-accelerated Inverse Distance Weighting (IDW) interpolation algorithm. First we redesign and improve our previous GPU implementation that was performed by exploiting the feature of CUDA dynamic parallelism (CDP). Then we implement three versions of GPU implementations, i.e., the naive version, the tiled version, and the improved CDP version, based upon five data layouts, including the Structure of Arrays (SoA), the Array of Structures (AoS), the Array of aligned Structures (AoaS), the Structure of Arrays of aligned Structures (SoAoS), and the Hybrid layout. We also carry out several groups of experimental tests to evaluate the impact. Experimental results show that: the layouts AoS and AoaS achieve better performance than the layout SoA for both the naive version and tiled version, while the layout SoA is the best choice for the improved CDP version. We also observe that: for the two combined data layouts (the SoAoS and the Hybrid), there are no notable performance gains when compared to other three basic layouts. We recommend that: in practical applications, the layout AoaS is the best choice since the tiled version is the fastest one among three versions. The source code of all implementations are publicly available.

  2. Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.

    Science.gov (United States)

    Quentin, Y; Fichant, G; Denizot, F

    1999-04-02

    We have undertaken the inventory and assembly of the ATP binding cassette (ABC) transporter systems in the complete genome of Bacillus subtilis. We combined the identification of the three protein partners that compose an ABC transporter (nucleotide-binding domain, NBD; membrane spanning domain, MSD; and solute-binding protein, SBP) with constraints on the genetic organization. This strategy allowed the identification of 86 NBDs in 78 proteins, 103 MSD proteins and 37 SBPs. The analysis of transcriptional units allows the reconstruction of 59 ABC transporters, which include at least one NBD and one MSD. A particular class of five dimeric ATPases was not associated to MSD partners and is assumed to be involved either in macrolide resistance or regulation of translation elongation. In addition, we have detected five genes encoding ATPases without any gene coding for MSD protein in their neighborhood and 11 operons that encode only the membrane and solute-binding proteins. On the bases of similarities, three ATP-binding proteins are proposed to energize ten incomplete systems, suggesting that one ATPase may be recruited by more than one transporter. Finally, we estimate that the B. subtilis genome encodes for at least 78 ABC transporters that have been split in 38 importers and 40 extruders. The ABC systems have been further classified into 11 sub-families according to the tree obtained from the NBDs and the clustering of the MSDs and the SBPs. Comparisons with Escherichia coli show that the extruders are over-represented in B. subtilis, corresponding to an expansion of the sub-families of antibiotic and drug resistance systems. Copyright 1999 Academic Press.

  3. ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection.

    Science.gov (United States)

    Sharkey, Liam K R; Edwards, Thomas A; O'Neill, Alex J

    2016-03-22

    Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which these proteins act has been a subject of long-standing controversy, with two competing hypotheses each having gained considerable support: antibiotic efflux versus ribosomal protection. Here, we report on studies employing a combination of bacteriological and biochemical techniques to unravel the mechanism of resistance of these proteins, and provide several lines of evidence that together offer clear support to the ribosomal protection hypothesis. Of particular note, we show that addition of purified ABC-F proteins to anin vitrotranslation assay prompts dose-dependent rescue of translation, and demonstrate that such proteins are capable of displacing antibiotic from the ribosomein vitro To our knowledge, these experiments constitute the first direct evidence that ABC-F proteins mediate antibiotic resistance through ribosomal protection.IMPORTANCEAntimicrobial resistance ranks among the greatest threats currently facing human health. Elucidation of the mechanisms by which microorganisms resist the effect of antibiotics is central to understanding the biology of this phenomenon and has the potential to inform the development of new drugs capable of blocking or circumventing resistance. Members of the ABC-F family, which includelsa(A),msr(A),optr(A), andvga(A), collectively yield resistance to a broader range of clinically significant antibiotic classes than any other family of resistance determinants, although their mechanism of action has been controversial since their discovery 25 years ago. Here we present the first direct evidence that proteins of the ABC-F family act to protect the bacterial ribosome from antibiotic-mediated inhibition. Copyright © 2016 Sharkey et al.

  4. GPS-ABC radiated chamber testing overview and results : GPS-ABC Workshop VI : RTCA Washington, DC, March 30, 2017.

    Science.gov (United States)

    2017-03-30

    This presentation, which was given during the GPS-ABC Workshop VI in Washington, DC on March 30, 2017 details the authors' radiated testing protocols and results. GPS receiver testing was carried out April 25-29, 2016 at the Army : Research Laborator...

  5. Inventory and analysis of ATP-binding cassette (ABC) systems in Brugia malayi.

    Science.gov (United States)

    Ardelli, B F; Stitt, L E; Tompkins, J B

    2010-07-01

    ABC systems are one of the largest described protein superfamilies. These systems have a domain organization that may contain 1 or more transmembrane domains (ABC_TM1F) and 1 or 2 ATP-binding domains (ABC_2). The functions (e.g., import, export and DNA repair) of these proteins distinguish the 3 classes of ABC systems. Mining and PCR-based cloning were used to identify 33 putative ABC systems from the Brugia malayi genome. There were 31 class 2 genes, commonly called ABC transporters, and 2 class 3 genes. The ABC transporters were divided into subfamilies. Three belonged to subfamily A, 16 to subfamily B, 5 to subfamily C, 1 to subfamily E and 3 to subfamilies F and G, respectively. None were placed in subfamilies D and H. Similar to other ABC systems, the ABC_2 domain of B. malayi genes was conserved and contained the Walker A and B motifs, the signature sequence/linker region and the switch region with the conserved histidine. The ABC_TM1F domain was less conserved. The relative abundance of ABC systems was quantified using real-time reverse transcription PCR and was significantly higher in female adults of B. malayi than in males and microfilaria, particularly those in subfamilies B and C, which are associated with drug resistance.

  6. Inventory and comparative analysis of rice and Arabidopsis ATP-binding cassette (ABC) systems.

    Science.gov (United States)

    Garcia, Olivier; Bouige, Philippe; Forestier, Cyrille; Dassa, Elie

    2004-10-08

    ATP-binding cassette (ABC) proteins constitute a large superfamily found in all kingdoms of living organisms. The recent completion of two draft sequences of the rice (Oryza sativa) genome allowed us to analyze and classify its ABC proteins and to compare to those in Arabidopsis thaliana. We identified a similar number of ABC proteins in rice and Arabidopsis (121 versus 120), despite the rice genome being more than three times the size of Arabidopsis. Both Arabidopsis and rice have representative members in all seven major subfamilies of ABC ATPases (A to G) commonly found in eukaryotes. This comparative analysis allowed the detection of 29 potential orthologous sequences in Arabidopsis and rice. However, plant share with prokaryotes a specific set of ABC systems that is not detected in animals. These ABC systems might be inherited from the cyanobacterial ancestor of chloroplasts. The present work provides the first complete inventory of rice ABC proteins and an updated inventory of those proteins in Arabidopsis.

  7. 75 FR 49549 - ABC & D Recycling, Inc.-Lease and Operation Exemption-a Line of Railroad in Ware, MA

    Science.gov (United States)

    2010-08-13

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35397] ABC & D Recycling, Inc.--Lease and Operation Exemption--a Line of Railroad in Ware, MA ABC & D Recycling, Inc. (ABC & D...\\ The line is currently operated by the Massachusetts Central Railroad Corporation.\\2\\ \\1\\ ABC & D...

  8. A fast and efficient method for device level layout analysis

    Science.gov (United States)

    Dong, YaoQi; Zou, Elaine; Pang, Jenny; Huang, Lucas; Yang, Legender; Zhang, Chunlei; Du, Chunshan; Hu, Xinyi; Wan, Qijian

    2017-03-01

    There is an increasing demand for device level layout analysis, especially as technology advances. The analysis is to study standard cells by extracting and classifying critical dimension parameters. There are couples of parameters to extract, like channel width, length, gate to active distance, and active to adjacent active distance, etc. for 14nm technology, there are some other parameters that are cared about. On the one hand, these parameters are very important for studying standard cell structures and spice model development with the goal of improving standard cell manufacturing yield and optimizing circuit performance; on the other hand, a full chip device statistics analysis can provide useful information to diagnose the yield issue. Device analysis is essential for standard cell customization and enhancements and manufacturability failure diagnosis. Traditional parasitic parameters extraction tool like Calibre xRC is powerful but it is not sufficient for this device level layout analysis application as engineers would like to review, classify and filter out the data more easily. This paper presents a fast and efficient method based on Calibre equation-based DRC (eqDRC). Equation-based DRC extends the traditional DRC technology to provide a flexible programmable modeling engine which allows the end user to define grouped multi-dimensional feature measurements using flexible mathematical expressions. This paper demonstrates how such an engine and its programming language can be used to implement critical device parameter extraction. The device parameters are extracted and stored in a DFM database which can be processed by Calibre YieldServer. YieldServer is data processing software that lets engineers query, manipulate, modify, and create data in a DFM database. These parameters, known as properties in eqDRC language, can be annotated back to the layout for easily review. Calibre DesignRev can create a HTML formatted report of the results displayed in Calibre

  9. A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae

    Science.gov (United States)

    2013-01-01

    Background The ABC (ATP-binding cassette) gene superfamily is widespread across all living species. The majority of ABC genes encode ABC transporters, which are membrane-spanning proteins capable of transferring substrates across biological membranes by hydrolyzing ATP. Although ABC transporters have often been associated with resistance to drugs and toxic compounds, within the Arthropoda ABC gene families have only been characterized in detail in several insects and a crustacean. In this study, we report a genome-wide survey and expression analysis of the ABC gene superfamily in the spider mite, Tetranychus urticae, a chelicerate ~ 450 million years diverged from other Arthropod lineages. T. urticae is a major agricultural pest, and is among of the most polyphagous arthropod herbivores known. The species resists a staggering array of toxic plant secondary metabolites, and has developed resistance to all major classes of pesticides in use for its control. Results We identified 103 ABC genes in the T. urticae genome, the highest number discovered in a metazoan species to date. Within the T. urticae ABC gene set, all members of the eight currently described subfamilies (A to H) were detected. A phylogenetic analysis revealed that the high number of ABC genes in T. urticae is due primarily to lineage-specific expansions of ABC genes within the ABCC, ABCG and ABCH subfamilies. In particular, the ABCC subfamily harbors the highest number of T. urticae ABC genes (39). In a comparative genomic analysis, we found clear orthologous relationships between a subset of T. urticae ABC proteins and ABC proteins in both vertebrates and invertebrates known to be involved in fundamental cellular processes. These included members of the ABCB-half transporters, and the ABCD, ABCE and ABCF families. Furthermore, one-to-one orthologues could be distinguished between T. urticae proteins and human ABCC10, ABCG5 and ABCG8, the Drosophila melanogaster sulfonylurea receptor and ecdysone

  10. An efficient grid layout algorithm for biological networks utilizing various biological attributes

    Directory of Open Access Journals (Sweden)

    Kato Mitsuru

    2007-03-01

    Full Text Available Abstract Background Clearly visualized biopathways provide a great help in understanding biological systems. However, manual drawing of large-scale biopathways is time consuming. We proposed a grid layout algorithm that can handle gene-regulatory networks and signal transduction pathways by considering edge-edge crossing, node-edge crossing, distance measure between nodes, and subcellular localization information from Gene Ontology. Consequently, the layout algorithm succeeded in drastically reducing these crossings in the apoptosis model. However, for larger-scale networks, we encountered three problems: (i the initial layout is often very far from any local optimum because nodes are initially placed at random, (ii from a biological viewpoint, human layouts still exceed automatic layouts in understanding because except subcellular localization, it does not fully utilize biological information of pathways, and (iii it employs a local search strategy in which the neighborhood is obtained by moving one node at each step, and automatic layouts suggest that simultaneous movements of multiple nodes are necessary for better layouts, while such extension may face worsening the time complexity. Results We propose a new grid layout algorithm. To address problem (i, we devised a new force-directed algorithm whose output is suitable as the initial layout. For (ii, we considered that an appropriate alignment of nodes having the same biological attribute is one of the most important factors of the comprehension, and we defined a new score function that gives an advantage to such configurations. For solving problem (iii, we developed a search strategy that considers swapping nodes as well as moving a node, while keeping the order of the time complexity. Though a naïve implementation increases by one order, the time complexity, we solved this difficulty by devising a method that caches differences between scores of a layout and its possible updates

  11. Overview of the Westinghouse Small Modular Reactor building layout

    Energy Technology Data Exchange (ETDEWEB)

    Cronje, J. M. [Westinghouse Electric Company LLC, Centurion (South Africa); Van Wyk, J. J.; Memmott, M. J. [Westinghouse Electric Company LLC, Cranberry Township, PA (United States)

    2012-07-01

    The Westinghouse Small Modular Reactor (SMR) is an 800 MWt (>225 MWe) integral pressurized water reactor (iPWR), in which all of the components typically associated with the nuclear steam supply system (NSSS) of a nuclear power plant are incorporated within a single reactor pressure vessel. This paper is the third in a series of four papers, which describe the design and functionality of the Westinghouse SMR. It focuses in particular upon the plant building layout and modular design of the Westinghouse SMR. In the development of small modular reactors, the building layout is an area where the safety of the plant can be improved by applying new design approaches. This paper will present an overview of the Westinghouse SMR building layout and indicate how the design features improve the safety and robustness of the plant. The Westinghouse SMR is designed with no shared systems between individual reactor units. The main buildings inside the security fence are the nuclear island, the rad-waste building, the annex building, and the turbine building. All safety related equipment is located in the nuclear island, which is a seismic class 1 building. To further enhance the safety and robustness of the design, the reactor, containment, and most of the safety related equipment are located below grade on the nuclear island. This reduces the possibility of severe damage from external threats or natural disasters. Two safety related ultimate heat sink (UHS) water tanks that are used for decay heat removal are located above grade, but are redundant and physically separated as far as possible for improved safety. The reactor and containment vessel are located below grade in the center of the nuclear island. The rad-waste and other radioactive systems are located on the bottom floors to limit the radiation exposure to personnel. The Westinghouse SMR safety trains are completely separated into four unconnected quadrants of the building, with access between quadrants only allowed

  12. Superconducting resonators for telecommunication application based on fractal layout

    Energy Technology Data Exchange (ETDEWEB)

    Prigiobbo, A [INFM-COHERENTIA-Dipartimento Scienze Fisiche Universita di Napoli Federico II, Naples (Italy); Barra, M [INFM-COHERENTIA-Dipartimento Scienze Fisiche Universita di Napoli Federico II, Naples (Italy); Cassinese, A [INFM-COHERENTIA-Dipartimento Scienze Fisiche Universita di Napoli Federico II, Naples (Italy); Cirillo, M [INFM-Dipartimento Scienze Fisiche Universita di Roma TorVergata, Rome (Italy); Marafioti, F [INFM-COHERENTIA-Dipartimento Scienze Fisiche Universita di Napoli Federico II, Naples (Italy); Russo, R [INFM-Dipartimento Scienze Fisiche Universita di Roma TorVergata, Rome (Italy); Vaglio, R [INFM-COHERENTIA-Dipartimento Scienze Fisiche Universita di Napoli Federico II, Naples (Italy)

    2004-05-01

    In this paper the performances of superconducting devices based on fractal layout are discussed. Depending on their shape, fractals are characterized by self-similarity and/or space-filling properties. The former allows the design of superconducting filters with highly reduced dimensions and no appreciable loss of performance, whereas the latter is the basis for the fabrication of multi-band antennas which hold promise for very interesting applications. Our attention was focused on the square Koch loop and the Sierpinski gasket geometries. In particular, prototype four pole filters for UMTS (Universal Mobile Telecommunications Systems) applications based on Koch resonators have been designed. Measurements performed on prototype devices fabricated by using double-sided superconducting thin films are reported and compared with simulations.

  13. Methodology for bus layout for topological quantum error correcting codes

    Energy Technology Data Exchange (ETDEWEB)

    Wosnitzka, Martin; Pedrocchi, Fabio L.; DiVincenzo, David P. [RWTH Aachen University, JARA Institute for Quantum Information, Aachen (Germany)

    2016-12-15

    Most quantum computing architectures can be realized as two-dimensional lattices of qubits that interact with each other. We take transmon qubits and transmission line resonators as promising candidates for qubits and couplers; we use them as basic building elements of a quantum code. We then propose a simple framework to determine the optimal experimental layout to realize quantum codes. We show that this engineering optimization problem can be reduced to the solution of standard binary linear programs. While solving such programs is a NP-hard problem, we propose a way to find scalable optimal architectures that require solving the linear program for a restricted number of qubits and couplers. We apply our methods to two celebrated quantum codes, namely the surface code and the Fibonacci code. (orig.)

  14. The CERN-SPL Chopper Concept and Final Layout

    CERN Document Server

    Caspers, Friedhelm; Genest, J; Haase, M; Paoluzzi, M; Teixeira, A

    2004-01-01

    The fast chopper for the CERN SPL (Superconducting Proton Linac) consists of a double meander structure with β = v/c of 8 % printed on an alumina substrate for the deflecting plates. Each chopper unit is 50 cm long and housed in a quadrupole magnet surrounding the vacuum chamber. The deflecting plates are operated simultaneously in a dual mode, namely traveling wave mode for frequencies above about 10 MHz and as quasi electrostatic deflectors below. The deflecting structures are water-cooled to handle heating from beam losses as well as from the deflecting signal. A detailed mechanical layout is presented including the tri-axial feeding and termination technique as well as a discussion of the drive amplifier.

  15. A New Data Layout For Set Intersection on GPUs

    DEFF Research Database (Denmark)

    Amossen, Rasmus Resen; Pagh, Rasmus

    2011-01-01

    Set intersection is the core in a variety of problems, e.g. frequent itemset mining and sparse boolean matrix multiplication. It is well-known that large speed gains can, for some computational problems, be obtained by using a graphics processing unit (GPU) as a massively parallel computing device....... However, GPUs require highly regular control flow and memory access patterns, and for this reason previous GPU methods for intersecting sets have used a simple bitmap representation. This representation requires excessive space on sparse data sets. In this paper we present a novel data layout, BATMAP....... The main finding is that our method is able to achieve speedups over both Apriori and FP-growth when the number of distinct items is large, and the density of the problem instance is above 1%. Previous implementations of frequent itemset mining on GPU have not been able to show speedups over the best...

  16. Impact of Wisconsin Medicaid Policy Change on Dental Sealant Utilization.

    Science.gov (United States)

    Okunseri, Christopher; Okunseri, Elaye; Garcia, Raul I; Gonzalez, Cesar; Visotcky, Alexis; Szabo, Aniko

    2018-02-01

    In September 2006, Wisconsin Medicaid changed its policy to allow nondentists to become certified Medicaid providers and to bill for sealants in public health settings. This study examined changes in patterns of dental sealant utilization in first molars of Wisconsin Medicaid enrollees associated with a policy change. The Electronic Data Systems of Medicaid Evaluation and Decision Support for Wisconsin from 2001 to 2009. Retrospective claims data analysis of Wisconsin Dental Medicaid for children aged 6-16 years. A total of 479,847 children followed up for 1,441,300 person-years with 64,546 visits were analyzed. The rate of visits for sealants by dentists increased significantly from 3 percent per year prepolicy to 11 percent per year postpolicy, and that of nondentists increased from 18 percent per year to 20 percent after the policy change, but this was not significant. Non-Hispanic blacks had the lowest visit rates for sealant application by dentists and nondentists pre- and postpolicy periods. The Wisconsin Medicaid policy change was associated with increased rates of visits for dental sealant placement by dentists. The rate of visits with sealant placements by nondentists increased at the same rate pre- and postpolicy change. © Health Research and Educational Trust.

  17. Wisconsin Healthy Birth Outcomes: minority health program challenges and contributions.

    Science.gov (United States)

    Cruz, Evelyn; Guhleman, Patricia; Onheiber, Patrice Mocny

    2008-11-01

    For at least 20 years, the probability that an infant born in Wisconsin would die during the first year of life has been approximately three times greater for infants born to African American women than for those born to White women. Over the same period of time, other states have made improvements in African American infant mortality, whereas Wisconsin's ranking has fallen to last place. Various state and local efforts have been made to address the issue; however, it is only in the last 2 to 3 years that Wisconsin's high rate of African American infant mortality has become an agreed-upon health priority. This article discusses the factors that have converged to bring African American infant mortality to the forefront of Wisconsin public health policy and programs. Particular attention is given to the role of Wisconsin's Minority Health Program in relation to public health leadership and coalition building. Key actions currently underway to implement effective, evidence-based solutions are also described.

  18. Muskellunge growth potential in northern Wisconsin: implications for trophy management

    Science.gov (United States)

    Faust, Matthew D.; Isermann, Daniel A.; Luehring, Mark A.; Hansen, Michael J.

    2015-01-01

    The growth potential of Muskellunge Esox masquinongy was evaluated by back-calculating growth histories from cleithra removed from 305 fish collected during 1995–2011 to determine whether it was consistent with trophy management goals in northern Wisconsin. Female Muskellunge had a larger mean asymptotic length (49.8 in) than did males (43.4 in). Minimum ultimate size of female Muskellunge (45.0 in) equaled the 45.0-in minimum length limit, but was less than the 50.0-in minimum length limit used on Wisconsin's trophy waters, while the minimum ultimate size of male Muskellunge (34.0 in) was less than the statewide minimum length limit. Minimum reproductive sizes for both sexes were less than Wisconsin's trophy minimum length limits. Mean growth potential of female Muskellunge in northern Wisconsin appears to be sufficient for meeting trophy management objectives and angler expectations. Muskellunge in northern Wisconsin had similar growth potential to those in Ontario populations, but lower growth potential than Minnesota's populations, perhaps because of genetic and environmental differences.

  19. Studies of Inner Detector Layouts with 5 Pixel layers for the Phase-II Upgrade

    CERN Document Server

    Ludwig, A; The ATLAS collaboration; Garcia-Sciveres, M

    2013-01-01

    This note describes a study of Inner Detector layouts for the phase-II upgrade. Starting from the LOI layout the impact of adding a 5th pixel layer, and shortening the pixel and/or SCT barrel layers is studied.

  20. Multi-Criteria Layout Synthesis of MEMS Devices Using Memetic Computing

    DEFF Research Database (Denmark)

    Tutum, Cem Celal; Fan, Zhun

    2011-01-01

    This paper introduces a multi-objective optimization approach for layout synthesis of MEMS components. A case study of layout synthesis of a comb-driven micro-resonator shows that the approach proposed in this paper can lead to design results accommodating two design objectives, i.e. simultaneous...

  1. 33 CFR 127.105 - Layout and spacing of marine transfer area for LNG.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Layout and spacing of marine transfer area for LNG. 127.105 Section 127.105 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas § 127.105 Layout and...

  2. Extracting 3D layout from a single image using global image structures.

    Science.gov (United States)

    Lou, Zhongyu; Gevers, Theo; Hu, Ninghang

    2015-10-01

    Extracting the pixel-level 3D layout from a single image is important for different applications, such as object localization, image, and video categorization. Traditionally, the 3D layout is derived by solving a pixel-level classification problem. However, the image-level 3D structure can be very beneficial for extracting pixel-level 3D layout since it implies the way how pixels in the image are organized. In this paper, we propose an approach that first predicts the global image structure, and then we use the global structure for fine-grained pixel-level 3D layout extraction. In particular, image features are extracted based on multiple layout templates. We then learn a discriminative model for classifying the global layout at the image-level. Using latent variables, we implicitly model the sublevel semantics of the image, which enrich the expressiveness of our model. After the image-level structure is obtained, it is used as the prior knowledge to infer pixel-wise 3D layout. Experiments show that the results of our model outperform the state-of-the-art methods by 11.7% for 3D structure classification. Moreover, we show that employing the 3D structure prior information yields accurate 3D scene layout segmentation.

  3. 49 CFR 238.447 - Train operator's controls and power car cab layout.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train operator's controls and power car cab layout. 238.447 Section 238.447 Transportation Other Regulations Relating to Transportation (Continued... layout. (a) Train operator controls in the power car cab shall be arranged so as to minimize the chance...

  4. 33 CFR 127.1105 - Layout and spacing of marine transfer area for LHG.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Layout and spacing of marine transfer area for LHG. 127.1105 Section 127.1105 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Construction § 127.1105 Layout and spacing of marine transfer area for LHG. Each new waterfront facility...

  5. Design aspects of the alpha repository. II. Conceptual layouts of underground storage facilities

    International Nuclear Information System (INIS)

    Grams, W.H.

    1975-01-01

    Five conceptual repository layouts are presented: linear repository, 1 panel; bow tie repository, 2 panels; maltese cross repository, 4 panels; snowflake repository; 5 panels, and sash window repository, 8 panels. The layouts are compared with respect to excavation requirements, haulage distances, ventilation flow path designs, and safety features

  6. Sensitivity Analysis of WEC Array Layout Parameters Effect on the Power Performance

    DEFF Research Database (Denmark)

    Ruiz, Pau Mercadé; Ferri, Francesco; Kofoed, Jens Peter

    2015-01-01

    This study assesses the effect that the array layout choice has on the power performance. To this end, a sensitivity analysis is carried out with six array layout parameters, as the simulation inputs, the array power performance (q-factor), as the simulation output, and a simulation model specially...

  7. Layout level design for testability strategy applied to a CMOS cell library

    NARCIS (Netherlands)

    Blom, F.C.; Oliver, J.; Rullan, M.; Ferrer, C.

    1993-01-01

    The layout level design for testability (LLDFT) rules used here allow to avoid some hard to detect faults or even undetectable faults on a cell library by modifying the cell layout without changing their behavior and achieving a good level of reliability. These rules avoid some open faults or reduce

  8. A Novel Energy Yields Calculation Method for Irregular Wind Farm Layout

    DEFF Research Database (Denmark)

    Hou, Peng; Hu, Weihao; Soltani, Mohsen

    2015-01-01

    Due to the increasing size of offshore wind farm, the impact of the wake effect on energy yields become more and more evident. The Seafloor topography would limit the layout of the wind farm so that irregular layout is usually adopted inlarge scale offshore wind farm. However, the calculation...

  9. The changing pages of comics : Page layouts across eight decades of American superhero comics

    NARCIS (Netherlands)

    Pederson, Kaitlin; Cohn, Neil

    2016-01-01

    Page layouts are one of the most overt features of comics’ structure. We hypothesized that American superhero comics have changed in their page layout over eight decades, and investigated this using a corpus analysis of 40 comics from 1940 through 2014. On the whole, we found that comics pages

  10. Designing with Space Syntax : A configurative approach to architectural layout, proposing a computational methodology

    NARCIS (Netherlands)

    Nourian, P.; Rezvani, S.; Sariyildiz, I.S.

    2013-01-01

    This paper introduces a design methodology and a toolkit developed as a parametric CAD program for configurative design of architectural plan layouts. Using this toolkit, designers can start plan layout process with sketching the way functional spaces need to connect to each other. A tool draws an

  11. A Tool for the Automated Design and Evaluation of Habitat Interior Layouts

    Science.gov (United States)

    Simon, Matthew A.; Wilhite, Alan W.

    2013-01-01

    The objective of space habitat design is to minimize mass and system size while providing adequate space for all necessary equipment and a functional layout that supports crew health and productivity. Unfortunately, development and evaluation of interior layouts is often ignored during conceptual design because of the subjectivity and long times required using current evaluation methods (e.g., human-in-the-loop mockup tests and in-depth CAD evaluations). Early, more objective assessment could prevent expensive design changes that may increase vehicle mass and compromise functionality. This paper describes a new interior design evaluation method to enable early, structured consideration of habitat interior layouts. This interior layout evaluation method features a comprehensive list of quantifiable habitat layout evaluation criteria, automatic methods to measure these criteria from a geometry model, and application of systems engineering tools and numerical methods to construct a multi-objective value function measuring the overall habitat layout performance. In addition to a detailed description of this method, a C++/OpenGL software tool which has been developed to implement this method is also discussed. This tool leverages geometry modeling coupled with collision detection techniques to identify favorable layouts subject to multiple constraints and objectives (e.g., minimize mass, maximize contiguous habitable volume, maximize task performance, and minimize crew safety risks). Finally, a few habitat layout evaluation examples are described to demonstrate the effectiveness of this method and tool to influence habitat design.

  12. Yearbook and Magazine Layout, English, Journalism. Language Arts: 5113.200.

    Science.gov (United States)

    Adams, Marlene E.

    Developed as a quinmester unit for the high school on yearbook and magazine layout, this guide provides the teacher with suggested teaching strategies for a study of the theory and practice of page layout, photo cropping and editing, use of color and special effects, copy fitting and headline writing and fitting, and principles of typography.…

  13. Layout Geometry in the Selection of Intrinsic Frames of Reference from Multiple Viewpoints

    Science.gov (United States)

    Mou, Weimin; Zhao, Mintao; McNamara, Timothy P.

    2007-01-01

    Four experiments investigated the roles of layout geometry in the selection of intrinsic frames of reference in spatial memory. Participants learned the locations of objects in a room from 2 or 3 viewing perspectives. One view corresponded to the axis of bilateral symmetry of the layout, and the other view(s) was (were) nonorthogonal to the axis…

  14. Cost-Effectiveness Analysis of the Residential Provisions of the 2015 IECC for Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Mendon, Vrushali V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhao, Mingjie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Zachary T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Poehlman, Eric A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-02-15

    The 2015 IECC provides cost-effective savings for residential buildings in Wisconsin. Moving to the 2015 IECC from the 2006 IECC base code is cost-effective for residential buildings in all climate zones in Wisconsin.

  15. The predicted ABC transporter AbcEDCBA is required for type IV secretion system expression and lysosomal evasion by Brucella ovis.

    Directory of Open Access Journals (Sweden)

    Teane M A Silva

    Full Text Available Brucella ovis is a major cause of reproductive failure in rams and it is one of the few well-described Brucella species that is not zoonotic. Previous work showed that a B. ovis mutant lacking a species-specific ABC transporter (ΔabcBA was attenuated in mice and was unable to survive in macrophages. The aim of this study was to evaluate the role of this ABC transporter during intracellular survival of B. ovis. In HeLa cells, B. ovis WT was able to survive and replicate at later time point (48 hpi, whereas an ΔabcBA mutant was attenuated at 24 hpi. The reduced survival of the ΔabcBA mutant was associated with a decreased ability to exclude the lysosomal marker LAMP1 from its vacuolar membrane, suggesting a failure to establish a replicative niche. The ΔabcBA mutant showed a reduced abundance of the Type IV secretion system (T4SS proteins VirB8 and VirB11 in both rich and acid media, when compared to WT B. ovis. However, mRNA levels of virB1, virB8, hutC, and vjbR were similar in both strains. These results support the notion that the ABC transporter encoded by abcEDCBA or its transported substrate acts at a post-transcriptional level to promote the optimal expression of the B. ovis T4SS within infected host cells.

  16. A New Layout for English Letters on the Keyboard Using Evolutionary Strategy

    Directory of Open Access Journals (Sweden)

    Ali Asghar Poorhajikazam

    2015-10-01

    Full Text Available Since the keyboard is the primary device of entering text into a computer, a keyboard with letters on the proper layout of high performance is essential. Obtaining a suitable arrangements for the letters on the keyboard is an optimization problem which different methods have been proposed to solve it and its answer is the most appropriate permutation for letters on the keyboard which is 26 letters for English keyboard. In this paper, a new English keyboard layout has been proposed using evolutionary strategy which aims to increase typing speed and rectify some problems of current layout. To this end, a fitness function is used which includes parameters such as keys distance, fingers switch, frequency of use of both hands and etc. Different experiments have been conducted to evaluate the proposed approach and the results indicate that the obtained layout acts better than the current and other proposed layouts in the literature.

  17. Young children reorient by computing layout geometry, not by matching images of the environment.

    Science.gov (United States)

    Lee, Sang Ah; Spelke, Elizabeth S

    2011-02-01

    Disoriented animals from ants to humans reorient in accord with the shape of the surrounding surface layout: a behavioral pattern long taken as evidence for sensitivity to layout geometry. Recent computational models suggest, however, that the reorientation process may not depend on geometrical analyses but instead on the matching of brightness contours in 2D images of the environment. Here we test this suggestion by investigating young children's reorientation in enclosed environments. Children reoriented by extremely subtle geometric properties of the 3D layout: bumps and ridges that protruded only slightly off the floor, producing edges with low contrast. Moreover, children failed to reorient by prominent brightness contours in continuous layouts with no distinctive 3D structure. The findings provide evidence that geometric layout representations support children's reorientation.

  18. Economy analysis on vertical layout of conventional island of nuclear power plant

    International Nuclear Information System (INIS)

    Wang Xuefeng; Liu Xiaoyun; Liu Jinwei

    2011-01-01

    This paper briefly introduces the aboveground layout scheme and integral sinking layout scheme of conventional island of nuclear power plants. Technological-economic analysis formula are given, as a result, main factors influencing scheme selection is obtained. Determination of the layout scheme selection and optimization direction through the curve between the accumulative NPV and related factors is brought forward. The paper carries out the technological-economic comparison to the two schemes referred to a 1000 MW level nuclear power project as the example, getting the curve between the accumulative NPV and the plant ground elevation, and offering the method of selecting the vertical layout scheme of conventional island and vertical layout optimization direction. (authors)

  19. Using the clustered circular layout as an informative method for visualizing protein-protein interaction networks.

    Science.gov (United States)

    Fung, David C Y; Wilkins, Marc R; Hart, David; Hong, Seok-Hee

    2010-07-01

    The force-directed layout is commonly used in computer-generated visualizations of protein-protein interaction networks. While it is good for providing a visual outline of the protein complexes and their interactions, it has two limitations when used as a visual analysis method. The first is poor reproducibility. Repeated running of the algorithm does not necessarily generate the same layout, therefore, demanding cognitive readaptation on the investigator's part. The second limitation is that it does not explicitly display complementary biological information, e.g. Gene Ontology, other than the protein names or gene symbols. Here, we present an alternative layout called the clustered circular layout. Using the human DNA replication protein-protein interaction network as a case study, we compared the two network layouts for their merits and limitations in supporting visual analysis.

  20. A Layout for the Carbon Capture with Aqueous Ammonia without Salt Precipitation

    DEFF Research Database (Denmark)

    Bonalumi, Davide; Valenti, Gianluca; Lillia, Stefano

    2016-01-01

    Super Critical power plant. Two layouts are simulated with Aspen Plus employing the recently recalibrated Extended UNIQUAC thermodynamic model. The first one operates at chilling conditions, which yield to salt precipitation, and is taken as reference because already analyzed in previous studies....... The second layout operates at cooled conditions, which does not yield any salt precipitation. The Chilled layout reveals low specific heat duty and SPECCA equal to 2.2 and 2.86 MJ/kgco2, respectively. In contrast, the Cooled layout presents a higher specific heat duty of almost 3 MJ/kgco2 but, importantly......, a lower SPECCA of 2.58 MJ/kgco2. The latter layout is a better choice also from the perspective of the plant operation since it does not present the salt precipitation....

  1. Genome-wide comparative analysis of ABC systems in the Bdellovibrio-and-like organisms.

    Science.gov (United States)

    Li, Nan; Chen, Huan; Williams, Henry N

    2015-05-10

    Bdellovibrio-and-like organisms (BALOs) are gram-negative, predatory bacteria with wide variations in genome sizes and GC content and ecological habitats. The ATP-binding cassette (ABC) systems have been identified in several prokaryotes, fungi and plants and have a role in transport of materials in and out of cells and in cellular processes. However, knowledge of the ABC systems of BALOs remains obscure. A total of 269 putative ABC proteins were identified in BALOs. The genes encoding these ABC systems occupy nearly 1.3% of the gene content in freshwater Bdellovibrio strains and about 0.7% in their saltwater counterparts. The proteins found belong to 25 ABC system families based on their structural characteristics and functions. Among these, 16 families function as importers, 6 as exporters and 3 are involved in various cellular processes. Eight of these 25 ABC system families were deduced to be the core set of ABC systems conserved in all BALOs. All Bacteriovorax strains have 28 or less ABC systems. On the contrary, the freshwater Bdellovibrio strains have more ABC systems, typically around 51. In the genome of Bdellovibrio exovorus JSS (CP003537.1), 53 putative ABC systems were detected, representing the highest number among all the BALO genomes examined in this study. Unexpected high numbers of ABC systems involved in cellular processes were found in all BALOs. Phylogenetic analysis suggests that the majority of ABC proteins can be assigned into many separate families with high bootstrap supports (>50%). In this study, a general framework of sequence-structure-function connections for the ABC systems in BALOs was revealed providing novel insights for future investigations. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. ABC Transporters and the Alzheimer’s Disease Enigma

    Directory of Open Access Journals (Sweden)

    Andrea eWolf

    2012-06-01

    Full Text Available Alzheimer’s disease (AD is considered the disease of the 21st century. With a 10-fold increase in global incidence over the past 100 years, AD is now reaching epidemic proportions and by all projections, AD patient numbers will continue to rise. Despite intense research efforts, AD remains a mystery and effective therapies are still unavailable. This represents an unmet need resulting in clinical, social, and economic problems.Over the last decade, a new AD research focus has emerged: ATP-binding cassette (ABC transporters. In this article, we provide an overview of the ABC transporters ABCA1, ABCA2, P-glycoprotein (ABCB1, Mrp1 (ABCC1 and BCRP (ABCG2, all of which are expressed in the brain and have been implicated in AD. We summarize recent findings on the role of these five transporters in AD, and discuss their potential to serve as therapeutic targets.

  3. Magneto-optical properties of ABC-stacked trilayer graphene.

    Science.gov (United States)

    Lin, Yi-Ping; Lin, Chiun-Yan; Ho, Yen-Hung; Do, Thi-Nga; Lin, Ming-Fa

    2015-06-28

    The generalized tight-binding model is developed to investigate the magneto-optical absorption spectra of ABC-stacked trilayer graphene. The absorption peaks can be classified into nine categories of inter-Landau-level optical excitations, including three intra-group and six inter-group ones. Most of them belong to the twin-peak structures because of the asymmetric Landau level spectrum. The threshold absorption peak alone comes from a certain excitation channel, and its frequency is associated with a specific interlayer atomic interaction. The Landau-level anticrossings cause extra absorption peaks. Moreover, a simple relationship between the absorption frequency and the field strength is absent. The magneto-optical properties of ABC-stacked trilayer graphene are totally different from those of AAA- and ABA-stacked ones, such as the number, intensity and frequency of absorption peaks.

  4. [Peroxisomal ABC transporters and X-linked adrenoleukodystrophy].

    Science.gov (United States)

    Geillon, Flore; Trompier, Doriane; Gondcaille, Catherine; Lizard, Gérard; Savary, Stéphane

    2012-12-01

    X-linked adrenoleukodystrophy (X-ALD) is a complex neurodegenerative disease associated with mutations in the ABCD1 gene, which encodes for a peroxisomal ABC transporter. Thanks to the efforts of the ELA foundation and to the recent successes of gene therapy published in Science in 2009, X-ALD is better known but still remains poorly understood. The exact role of ABCD1 and its homologs, as well as the exact link between the biochemical and metabolic peroxisomal defects and the clinical symptoms of the disease remain to be elucidated. This review summarizes the knowledge concerning the subfamily D of the ABC transporter family and concerning X-ALD, the most frequent peroxisomal disorder. © 2012 médecine/sciences – Inserm / SRMS.

  5. Arnold Diffusion of Charged Particles in ABC Magnetic Fields

    Science.gov (United States)

    Luque, Alejandro; Peralta-Salas, Daniel

    2017-06-01

    We prove the existence of diffusing solutions in the motion of a charged particle in the presence of ABC magnetic fields. The equations of motion are modeled by a 3DOF Hamiltonian system depending on two parameters. For small values of these parameters, we obtain a normally hyperbolic invariant manifold and we apply the so-called geometric methods for a priori unstable systems developed by A. Delshams, R. de la Llave and T.M. Seara. We characterize explicitly sufficient conditions for the existence of a transition chain of invariant tori having heteroclinic connections, thus obtaining global instability (Arnold diffusion). We also check the obtained conditions in a computer-assisted proof. ABC magnetic fields are the simplest force-free-type solutions of the magnetohydrodynamics equations with periodic boundary conditions, and can be considered as an elementary model for the motion of plasma-charged particles in a tokamak.

  6. Learning the ABCs: Activity based costing in waste operations

    International Nuclear Information System (INIS)

    Zocher, Marc A.

    1992-01-01

    The United States Department of Energy (DOE) is facing a challenging new national role based on current world events, changing public perception and awareness, and a legacy of wastes generated in the past. Clearly, the DOE must put mechanisms in place to comply with environmental rules, regulations, and good management practices so that public health risk is minimized while programmatic costs are controlled. DOE has begun this process and has developed a Five-Year Plan to describe the activities necessary to comply with both cleanup, or environmental restoration, and waste management of existing waste streams. The focus of this paper is how to best manage the treatment, storage, disposal, and transportation of waste throughout the DOE weapons complex by using Activity Based Costing (ABC) to both plan and control expenditures in DOE Waste Management (WM). The basics of ABC, along with an example, will be detailed. (author)

  7. IMPLEMENTATION OF THE ABC COSTING IN A SERVICES PROVIDER COMPANY

    Directory of Open Access Journals (Sweden)

    Luiz Ricardo Aguena Jacintho Gil de Castro

    2012-12-01

    Full Text Available This paper describes the implementation of the Activity-Based Cost (ABC method in a company of taxes and accounting services and outlines the positive and negative aspects encountered during implementation. It should be taken into account that this work has been developed in the fiscal area of cost verification. Bibliographical references, internal company documents and interviews with industry officials and the administrator responsible for the company were used. In the evolving of operations, the costs of the fiscal area and their main activities have been described monthly and through this information, drivers have been developed and the ABC (Activity-Based Costing method has been adopted. With the implementation it became clear that the system provides better visualization for the decision making process, it also provided learning for the company, so that the method should be used for an undetermined period of time.

  8. Second-order nonlinear optical metamaterials: ABC-type nanolaminates

    Energy Technology Data Exchange (ETDEWEB)

    Alloatti, L., E-mail: alloatti@mit.edu; Kieninger, C.; Lauermann, M.; Köhnle, K. [Institute of Photonics and Quantum Electronics (IPQ), Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); Froelich, A.; Wegener, M. [Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); DFG-Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76021 Karlsruhe (Germany); Frenzel, T. [Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); Freude, W. [Institute of Photonics and Quantum Electronics (IPQ), Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); Institute for Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); Leuthold, J.; Koos, C., E-mail: christian.koos@kit.edu [Institute of Photonics and Quantum Electronics (IPQ), Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); DFG-Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76128 Karlsruhe (Germany); Institute for Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany)

    2015-09-21

    We demonstrate a concept for second-order nonlinear metamaterials that can be obtained from non-metallic centrosymmetric constituents with inherently low optical absorption. The concept is based on iterative atomic-layer deposition of three different materials, A = Al{sub 2}O{sub 3}, B = TiO{sub 2}, and C = HfO{sub 2}. The centrosymmetry of the resulting ABC stack is broken since the ABC and the inverted CBA sequences are not equivalent—a necessary condition for non-zero second-order nonlinearity. In our experiments, we find that the bulk second-order nonlinear susceptibility depends on the density of interfaces, leading to a nonlinear susceptibility of 0.26 pm/V at a wavelength of 800 nm. ABC-type nanolaminates can be deposited on virtually any substrate and offer a promising route towards engineering of second-order optical nonlinearities at both infrared and visible wavelengths.

  9. ABC and VED Analysis in Medical Stores Inventory Control.

    Science.gov (United States)

    Gupta, R; Gupta, K K; Jain, B R; Garg, R K

    2007-10-01

    The basic principle of inventory control is ABC based on cost criteria and VED on criticality. Based on ABC-VED matrix, economic analysis of drug expenditure of priced vocabulary of medical stores (PVMS) section 01 for the year 2003 of a 190 bedded service hospital was under taken. Out of 493 drugs in PVMS section 01, only 325 drugs were being used in the reference hospital. The total cost of drugs used was Rupees 55,23,503. Of these 325 drugs, 47(14.4%) drugs were Category A, consuming 70% of total expenditure, 73 (22.46 %) drugs Category B consuming 20% and rest 205 drugs (63.7 %) Category C drugs cost only 10% of expenditure. VED categorization done by consensus opinion of medical officers, found 24 (7.3%) drugs vital, 160 (49.3%) essential and rest 141 (43.3 %) desirable. On coupling the two techniques ABC-VED matrix was made and drugs were classified in to Category I (AV+BV+CV+AE+AD) comprising 68 drugs, Category II (BE + CE +BD) 159 and Category III (CD) 98 drugs. The management of Category I drugs was monitored by top management resulting in better control on the annual expenses and at the same time making available the vital Category II by middle and Category III at lower mangerial level.

  10. High-level assessment of LANL ABC Design

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-15

    An annual weapon`s grade Pu disposition goal should be stated and related to the amount of Pu that needs to be disposed of. It needs to be determined to what extent it is possible to destroy Pu without building up any new Pu, i.e., how realistic this goal is. The strong positive Doppler coefficient for a Pu core might require the addition of some fertile material to ensure a negative Doppler coefficient. This in turn will affect the net Pu disposition rate. If a fertile material is required throughout the life of the ABC to ensure a negative Doppler coefficient, the difference between the molten salt ABC and other reactors in regard to Pu disposition is not a principled difference anymore but one of degree. A rationale has then to be developed that explains why {open_quotes}x{close_quotes} kg production of fissile material are acceptable but {open_quotes}y{close_quotes} kg are not. It is important to determine how a requirement for electricity production will impact on the ABC design choices. It is conceivable that DOE will not insist on electricity generation. In this case advantage has to be taken in terms of design simplifications and relaxed operating conditions.

  11. Of Needles and Haystacks: Building an Accurate Statewide Dropout Early Warning System in Wisconsin

    Science.gov (United States)

    Knowles, Jared E.

    2015-01-01

    The state of Wisconsin has one of the highest four year graduation rates in the nation, but deep disparities among student subgroups remain. To address this the state has created the Wisconsin Dropout Early Warning System (DEWS), a predictive model of student dropout risk for students in grades six through nine. The Wisconsin DEWS is in use…

  12. 77 FR 71587 - Wisconsin Public Service Corporation; Notices of Intent To File License Applications, Filing of...

    Science.gov (United States)

    2012-12-03

    ... Energy Regulatory Commission Wisconsin Public Service Corporation; Notices of Intent To File License.... d. Submitted By: Wisconsin Public Service Corporation. e. Name of Projects: Tomahawk Hydroelectric..., Vice President, Energy Supply Operations, Wisconsin Public Service Corporation, P.O. Box 19001, 700...

  13. 76 FR 48841 - Wisconsin Public Service Corporation; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2011-08-09

    ... Energy Regulatory Commission Wisconsin Public Service Corporation; Notice of Application for Amendment of..., 2011. d. Applicant: Wisconsin Public Service Corporation. e. Name of Project: High Falls Project. f.... 791a-825r. h. Applicant Contact: James Nuthals, Wisconsin Public Service Corporation, 700 North Adams...

  14. Introduction to radioactive waste management issues in Wisconsin

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This brief focused on wastes from commercial production of electricity and various industrial, medical and research applications of radioactive materials. Only traditionally solid wastes are dealt with. It was organized into five parts. Part I presented an introduction to radioactivity - what it is and the biological hazards associated with it. Federal regulation of the management of radioactive wastes was discussed in Part II. Existing state laws and bills currently before the Wisconsin Legislature were described in Part III. Part IV gave background information on specific areas of potential inquiry related to radioactive wastes in Wisconsin. Part V summarized the issues identified in the brief. 2 figures, 7 tables

  15. Biblioteca y Centro de Estudios de la Universidad de Wisconsin - Kenosha - . Wisconsin – (EE.UU.

    Directory of Open Access Journals (Sweden)

    Hellmuth, George

    1978-12-01

    Full Text Available Continuing the line established by these same architects in previous University designs, the Library and Study Hall of the University of Wisconsin is another attempt at creating an exciting atmosphere, particularly conducive to the development of university life. It is to be noted, in this case, the arrangement of the library and study areas around a central common open space, sort of an inner courtyard used as a relaxation and sitting área, where all traffic corridors and promenades from the adjacent faculties come to meet, thus becoming the main reference point for the entire campus. The library with a current capacity for 245,000 volumes and 1,400 reading stalls is designed so it can be eventually enlarged permitting to almost double its book capacity and increasing the reading stalls to more than 2,000.

    Continuando la línea marcada por estos mismos arquitectos en anteriores proyectos de universidades, la biblioteca y el centro de estudios de la Universidad de Wisconsin procura definir atractivos espacios para el desarrollo de la vida universitaria. En este caso destaca la organización de los servicios de biblioteca y estudio en torno a un espacio comunitario central, a modo de plaza interior, destinado a sala de estar y recreo, y en donde confluyen las circulaciones que provienen de los locales adyacentes, convirtiéndolo en el principal punto de referencia del campus universitario. La biblioteca, que actualmente tiene capacidad para 245.000 volúmenes y 1.400 lectores, ha previsto una ampliación que le permitirá casi doblar el número de volúmenes y proporcionar espacio para más de 2.000 lectores.

  16. Creating a Single South African Keyboard Layout to Promote Language

    Directory of Open Access Journals (Sweden)

    Dwayne Bailey

    2011-10-01

    Full Text Available

    Abstract: In this case study, a description is given of a keyboard layout designed to address the input needs of South African languages, specifically Venda, a language which would otherwise be impossible to type on a computer. In creating this keyboard, the designer, Translate.org.za, uses a practical intervention that transforms technology from a means harming a language into one ensuring the creation and preservation of good language resources for minority languages. The study first looks at the implications and consequences of this missing keyboard, and then follows the process from conception, strategy, research and design to the final user response. Not only are problems such as researching the orthographies, key placement and keyboard input options examined, but strategic objectives such as ensuring its wide adoption and creating a multilingual keyboard for all South African languages are also discussed. The result is a keyboard that furthers multilingualism and ensures the capturing of good data for future research. Finally it is a tool helping to boost and bolster the vitality of a language.

    Keywords: KEYBOARD, MULTILINGUALISM, VENDA, AFRIKAANS, TSWANA, NORTH-ERN SOTHO, ZULU, SOURCE, FREE SOFTWARE, LAYOUT

    Opsomming: Die skep van 'n enkelvoudige Suid-Afrikaanse toetsborduit-leg om taal te bevorder. In hierdie gevallestudie word 'n beskrywing gegee van die ontwerp van 'n sleutelborduitleg vir die hantering van die insetbehoeftes van Suid-Afrikaanse tale, veral Venda, 'n taal wat andersins onmoontlik op 'n rekenaar getik sou kon word. Deur die skep van hierdie sleutelbord gebruik die ontwerper, Translate.org.za, 'n praktiese ingryp wat tegnologie verander van 'n middel wat 'n taal benadeel tot een wat die skep en bewaring van nuttige taal-hulpbronne vir minderheidstale verseker. Die studie kyk eers na die implikasies en gevolge van hierdie ontbrekende sleutelbord, en volg dan die proses van konsepsie, strategie, navorsing en

  17. Glacial Lake Lind, Wisconsin and Minnesota

    Science.gov (United States)

    Johnson, M.D.; Addis, K.L.; Ferber, L.R.; Hemstad, C.B.; Meyer, G.N.; Komai, L.T.

    1999-01-01

    Glacial Lake Lind developed in the pre-late Wisconsinan St. Croix River valley, Minnesota and Wisconsin, and lasted more than 1000 yr during the retreat of the Superior lobe at the end of the Wisconsinan glaciation. Lake Lind sediment consists primarily of red varved silt and clay, but also includes mud-flow deposits, nearshore silt (penecontemporaneously deformed in places), nearshore rippled sand, and deltaic sand. Lake Lind varved red clay is not part of glacial Lake Grantsburg, as suggested by earlier authors, because the red varves are separated from overlying glacial Lake Grantsburg silt and clay by a unit of deltaic and fluvial sand. Furthermore, varve correlations indicate that the base of the red varves is younger to the north, showing that the basin expanded as the Superior lobe retreated and was not a lake basin dammed to the southwest by the advancing Grantsburg sublobe. Varve correlations indicate that the Superior lobe retreated at a rate of about 200 m/yr. Uniform winter-clay thickness throughout most of the varve couplets suggests thermal stratification in the lake with clay trapped in the epilimnion; some clay would exit the lake at the outlet prior to winter freeze. Zones of thicker winter-clay layers, in places associated with mud-flow layers, indicate outlet incision, lake-level fall, and shoreline erosion and resuspension of lake clay. The most likely outlet for glacial Lake Lind was in the southwest part of the lake near the present site of Minneapolis, Minnesota. Nearshore sediment indicates that the lake level of glacial Lake Lind was around 280 m. The elevation of the base of the Lake Lind sediments indicates water depth was 20 to 55 m. Evidence in the southern part of the lake basin suggests that the Superior lobe readvanced at least once during the early stages of glacial Lake Lind. Lake Lind ended not by drainage but by being filled in by prograding deltas and outwash plains composed of sand derived from the retreating Superior lobe. It

  18. Object Detection Based on Template Matching through Use of Best-So-Far ABC

    Directory of Open Access Journals (Sweden)

    Anan Banharnsakun

    2014-01-01

    Full Text Available Best-so-far ABC is a modified version of the artificial bee colony (ABC algorithm used for optimization tasks. This algorithm is one of the swarm intelligence (SI algorithms proposed in recent literature, in which the results demonstrated that the best-so-far ABC can produce higher quality solutions with faster convergence than either the ordinary ABC or the current state-of-the-art ABC-based algorithm. In this work, we aim to apply the best-so-far ABC-based approach for object detection based on template matching by using the difference between the RGB level histograms corresponding to the target object and the template object as the objective function. Results confirm that the proposed method was successful in both detecting objects and optimizing the time used to reach the solution.

  19. Object Detection Based on Template Matching through Use of Best-So-Far ABC

    Science.gov (United States)

    2014-01-01

    Best-so-far ABC is a modified version of the artificial bee colony (ABC) algorithm used for optimization tasks. This algorithm is one of the swarm intelligence (SI) algorithms proposed in recent literature, in which the results demonstrated that the best-so-far ABC can produce higher quality solutions with faster convergence than either the ordinary ABC or the current state-of-the-art ABC-based algorithm. In this work, we aim to apply the best-so-far ABC-based approach for object detection based on template matching by using the difference between the RGB level histograms corresponding to the target object and the template object as the objective function. Results confirm that the proposed method was successful in both detecting objects and optimizing the time used to reach the solution. PMID:24812556

  20. ABC Dementia Scale: A Quick Assessment Tool for Determining Alzheimer’s Disease Severity

    Directory of Open Access Journals (Sweden)

    Takahiro Mori

    2018-03-01

    Full Text Available Background: In this study, we examined the construct validity, concurrent validity concerning other standard scales, intrarater reliability, and changes in scores at 12 weeks of the previously developed ABC Dementia Scale (ABC-DS, a novel assessment tool for Alzheimer’s disease (AD. Methods: Data were obtained from 312 patients diagnosed with either AD or mild cognitive impairment. The scores on the ABC-DS and standard scales were compared. Results: The 13 items of the ABC-DS are grouped into three domains, and the domain-level scores were highly correlated with the corresponding conventional scales. Statistically significant changes in assessment scores after 12 weeks were observed for the total ABC-DS scores. Conclusion: Our results demonstrate the ABC-DS to have good validity and reliability, and its usefulness in busy clinical settings.

  1. Applying ABC Analysis to the Navy’s Inventory Management System

    Science.gov (United States)

    2014-09-01

    TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE APPLYING ABC ANALYSIS TO THE NAVY’S INVENTORY MANAGEMENT SYSTEM 5. FUNDING NUMBERS 6...Parts, Navy Enterprise Resource Planning, ABC Inventory Classification. 15. NUMBER OF PAGES 101 16. PRICE CODE 17. SECURITY CLASSIFICATION OF...for public release; distribution is unlimited APPLYING ABC ANALYSIS TO THE NAVY’S INVENTORY MANAGEMENT SYSTEM Benjamin May Lieutenant

  2. Drainage trans vesical d'un abces prostatique chez un sujet infecte ...

    African Journals Online (AJOL)

    Nous rapportons un cas d'abcès prostatique drainé avec succès par voie chirurgicale transvésicale chez un homme infecté par le VIH. Nous discutons les différentes méthodes de drainage de l'abcès prostatique et situons la place du drainage trans-vésical. Mots clés: abcès prostatique, VIH, chirurgie, Lomé, Togo.

  3. Creating an iPhone application for collecting continuous ABC data.

    Science.gov (United States)

    Whiting, Seth W; Dixon, Mark R

    2012-01-01

    This paper provides an overview and task analysis for creating a continuous ABC data-collection application using Xcode on a Mac computer. Behavior analysts can program an ABC data collection system, complete with a customized list of target clients, antecedents, behaviors, and consequences to be recorded, and have the data automatically sent to an e-mail account after observations have concluded. Further suggestions are provided to customize the ABC data- collection system for individual preferences and clinical needs.

  4. Environmental layout complexity affects neural activity during navigation in humans.

    Science.gov (United States)

    Slone, Edward; Burles, Ford; Iaria, Giuseppe

    2016-05-01

    Navigating large-scale surroundings is a fundamental ability. In humans, it is commonly assumed that navigational performance is affected by individual differences, such as age, sex, and cognitive strategies adopted for orientation. We recently showed that the layout of the environment itself also influences how well people are able to find their way within it, yet it remains unclear whether differences in environmental complexity are associated with changes in brain activity during navigation. We used functional magnetic resonance imaging to investigate how the brain responds to a change in environmental complexity by asking participants to perform a navigation task in two large-scale virtual environments that differed solely in interconnection density, a measure of complexity defined as the average number of directional choices at decision points. The results showed that navigation in the simpler, less interconnected environment was faster and more accurate relative to the complex environment, and such performance was associated with increased activity in a number of brain areas (i.e. precuneus, retrosplenial cortex, and hippocampus) known to be involved in mental imagery, navigation, and memory. These findings provide novel evidence that environmental complexity not only affects navigational behaviour, but also modulates activity in brain regions that are important for successful orientation and navigation. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  5. LADS: Optimizing Data Transfers using Layout-Aware Data Scheduling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngjae [ORNL; Atchley, Scott [ORNL; Vallee, Geoffroy R [ORNL; Shipman, Galen M [ORNL

    2015-01-01

    While future terabit networks hold the promise of signifi- cantly improving big-data motion among geographically distributed data centers, significant challenges must be overcome even on today s 100 gigabit networks to real- ize end-to-end performance. Multiple bottlenecks exist along the end-to-end path from source to sink. Data stor- age infrastructure at both the source and sink and its in- terplay with the wide-area network are increasingly the bottleneck to achieving high performance. In this paper, we identify the issues that lead to congestion on the path of an end-to-end data transfer in the terabit network en- vironment, and we present a new bulk data movement framework called LADS for terabit networks. LADS ex- ploits the underlying storage layout at each endpoint to maximize throughput without negatively impacting the performance of shared storage resources for other users. LADS also uses the Common Communication Interface (CCI) in lieu of the sockets interface to use zero-copy, OS-bypass hardware when available. It can further im- prove data transfer performance under congestion on the end systems using buffering at the source using flash storage. With our evaluations, we show that LADS can avoid congested storage elements within the shared stor- age resource, improving I/O bandwidth, and data transfer rates across the high speed networks.

  6. LAYOUT AND DESIGN OF ELECTROMOBILE CHARGING STATIONS AS URBAN ELEMENTS

    Directory of Open Access Journals (Sweden)

    Tomáš Chovan

    2015-12-01

    Full Text Available The contribution is dedicated to the processing of the problems of the insufficient charging for the electric vehicles within the concrete urbanistic centre. It brings a different perspective on the mobility, which is shown in the form of electric energy as the alternative for the needs of urbanization of the cities. It analyses electromobility, new technologies in the field of electric vehicles and the charging stations as the elements of the urbanism. In terms of the solution, the contribution is focused on the Košice city and the location of the public charging stations. Košice do not have sufficient amount of the public charging stations and until the 2014 there was only one public charging station. The contribution is focused on the designing of the parking places with the charging station placed on the appropriate parking places. The resulting design is created in the CAD system, it brings the view of the layout of the charging station at the shopping centre in the open space and in the parking house.

  7. Sandia Agile MEMS Prototyping, Layout Tools, Education and Services Program

    Energy Technology Data Exchange (ETDEWEB)

    Schriner, H.; Davies, B.; Sniegowski, J.; Rodgers, M.S.; Allen, J.; Shepard, C.

    1998-05-01

    Research and development in the design and manufacture of Microelectromechanical Systems (MEMS) is growing at an enormous rate. Advances in MEMS design tools and fabrication processes at Sandia National Laboratories` Microelectronics Development Laboratory (MDL) have broadened the scope of MEMS applications that can be designed and manufactured for both military and commercial use. As improvements in micromachining fabrication technologies continue to be made, MEMS designs can become more complex, thus opening the door to an even broader set of MEMS applications. In an effort to further research and development in MEMS design, fabrication, and application, Sandia National Laboratories has launched the Sandia Agile MEMS Prototyping, Layout Tools, Education and Services Program or SAMPLES program. The SAMPLES program offers potential partners interested in MEMS the opportunity to prototype an idea and produce hardware that can be used to sell a concept. The SAMPLES program provides education and training on Sandia`s design tools, analysis tools and fabrication process. New designers can participate in the SAMPLES program and design MEMS devices using Sandia`s design and analysis tools. As part of the SAMPLES program, participants` designs are fabricated using Sandia`s 4 level polycrystalline silicon surface micromachine technology fabrication process known as SUMMiT (Sandia Ultra-planar, Multi-level MEMS Technology). Furthermore, SAMPLES participants can also opt to obtain state of the art, post-fabrication services provided at Sandia such as release, packaging, reliability characterization, and failure analysis. This paper discusses the components of the SAMPLES program.

  8. Automatic pattern localization across layout database and photolithography mask

    Science.gov (United States)

    Morey, Philippe; Brault, Frederic; Beisser, Eric; Ache, Oliver; Röth, Klaus-Dieter

    2016-03-01

    Advanced process photolithography masks require more and more controls for registration versus design and critical dimension uniformity (CDU). The distribution of the measurement points should be distributed all over the whole mask and may be denser in areas critical to wafer overlay requirements. This means that some, if not many, of theses controls should be made inside the customer die and may use non-dedicated patterns. It is then mandatory to access the original layout database to select patterns for the metrology process. Finding hundreds of relevant patterns in a database containing billions of polygons may be possible, but in addition, it is mandatory to create the complete metrology job fast and reliable. Combining, on one hand, a software expertise in mask databases processing and, on the other hand, advanced skills in control and registration equipment, we have developed a Mask Dataprep Station able to select an appropriate number of measurement targets and their positions in a huge database and automatically create measurement jobs on the corresponding area on the mask for the registration metrology system. In addition, the required design clips are generated from the database in order to perform the rendering procedure on the metrology system. This new methodology has been validated on real production line for the most advanced process. This paper presents the main challenges that we have faced, as well as some results on the global performances.

  9. International Thermonuclear Experimental Reactor (ITER) plant layout and site services

    International Nuclear Information System (INIS)

    Chuyanov, V.

    1999-01-01

    The ITER site has not been determined at this time. Nevertheless, to develop a construction plan and a cost estimate, it is necessary to have a detailed layout of the buildings, structures, and outdoor equipment integrated with the balance of plant service systems prototypical of large fusion power plants. These services include electric power for magnet feeds and plasma heating systems, cryogenic and conventional cooling systems, compressed air, gas supplies, de-mineralized water, steam, and drainage. Nuclear grade facilities are provided to handle tritium fuel and activated waste, as well as to prevent radioactive exposure of either the workers or the public. To avoid interference between services of different types and for efficient arrangement of buildings, structures, and equipment within the site area, a plan was developed which segregated different classes of services to four quadrants surrounding the tokamak building, placed at the approximate geographic center of the site. Location of the twenty-seven buildings on the generic site was selected to meet all design requirements at minimum total project cost. A similar approach has been used to determine the location of services above, at, and below grade. The generic site plan can be adapted to the site selected for ITER without significant changes to the buildings or equipment. Some rearrangements may be required by site topography resulting primarily in changes to the length of services that link the buildings and equipment. (author)

  10. International Thermonuclear Experimental Reactor (ITER) plant layout and site services

    International Nuclear Information System (INIS)

    Chuyanov, V.

    2001-01-01

    The ITER site has not been determined at this time. Nevertheless, to develop a construction plan and a cost estimate, it is necessary to have a detailed layout of the buildings, structures, and outdoor equipment integrated with the balance of plant service systems prototypical of large fusion power plants. These services include electric power for magnet feeds and plasma heating systems, cryogenic and conventional cooling systems, compressed air, gas supplies, de-mineralized water, steam, and drainage. Nuclear grade facilities are provided to handle tritium fuel and activated waste, as well as to prevent radioactive exposure of either the workers or the public. To avoid interference between services of different types and for efficient arrangement of buildings, structures, and equipment within the site area, a plan was developed which segregated different classes of services to four quadrants surrounding the tokamak building, placed at the approximate geographic center of the site. Location of the twenty-seven buildings on the generic site was selected to meet all design requirements at minimum total project cost. A similar approach has been used to determine the location of services above, at, and below grade. The generic site plan can be adapted to the site selected for ITER without significant changes to the buildings or equipment. Some rearrangements may be required by site topography resulting primarily in changes to the length of services that link the buildings and equipment. (author)

  11. Development of a Layout Model Suitable for the Food Processing Industry

    Directory of Open Access Journals (Sweden)

    W. N. C. Wanniarachchi

    2016-01-01

    Full Text Available The food processing industry is a subset of the manufacturing sector with unique challenges. Among these, ensuring food hygiene and preventing contamination are two issues of prime importance. Hence, designers have to overcome such challenges when designing facilities suitable for food processing. The paper formulates a model that simplifies the layout planning process for the food processing facilities (FPF in order to help the designers. A generalised framework that helps to visualise the Facilities Layout Problem (FLP was initially developed. A layout model for FPF was then developed considering the unique features that need to be present in the layout. The model classifies the areas of FPF into five: primary, secondary, utilities, warehouse, and administration based on the activities and the level of risk present in food processing. It further proposes specific locations for the five sections in the factory layout. In order to test the performance of the framework and the model, a case study was conducted in a malted milk powder processing facility in Sri Lanka by changing its layout according to the proposed model. The framework and the model showed promise in its implementation. However, the approach and the layout model need to be evaluated in further cases in order to ascertain their usability and performance.

  12. Safety assessment in plant layout design using indexing approach: Implementing inherent safety perspective

    International Nuclear Information System (INIS)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2008-01-01

    The design of layout plans requires adequate assessment tools for the quantification of safety performance. The general focus of the present work is to introduce an inherent safety perspective at different points of the layout design process. In particular, index approaches for safety assessment and decision-making in the early stages of layout design are developed and discussed in this two-part contribution. Part 1 (accompanying paper) of the current work presents an integrated index approach for safety assessment of early plant layout. In the present paper (Part 2), an index for evaluation of the hazard related to the potential of domino effects is developed. The index considers the actual consequences of possible escalation scenarios and scores or ranks the subsequent accident propagation potential. The effects of inherent and passive protection measures are also assessed. The result is a rapid quantification of domino hazard potential that can provide substantial support for choices in the early stages of layout design. Additionally, a case study concerning selection among various layout options is presented and analyzed. The case study demonstrates the use and applicability of the indices developed in both parts of the current work and highlights the value of introducing inherent safety features early in layout design

  13. Safety assessment in plant layout design using indexing approach: Implementing inherent safety perspective

    International Nuclear Information System (INIS)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2008-01-01

    Layout planning plays a key role in the inherent safety performance of process plants since this design feature controls the possibility of accidental chain-events and the magnitude of possible consequences. A lack of suitable methods to promote the effective implementation of inherent safety in layout design calls for the development of new techniques and methods. In the present paper, a safety assessment approach suitable for layout design in the critical early phase is proposed. The concept of inherent safety is implemented within this safety assessment; the approach is based on an integrated assessment of inherent safety guideword applicability within the constraints typically present in layout design. Application of these guidewords is evaluated along with unit hazards and control devices to quantitatively map the safety performance of different layout options. Moreover, the economic aspects related to safety and inherent safety are evaluated by the method. Specific sub-indices are developed within the integrated safety assessment system to analyze and quantify the hazard related to domino effects. The proposed approach is quick in application, auditable and shares a common framework applicable in other phases of the design lifecycle (e.g. process design). The present work is divided in two parts: Part 1 (current paper) presents the application of inherent safety guidelines in layout design and the index method for safety assessment; Part 2 (accompanying paper) describes the domino hazard sub-index and demonstrates the proposed approach with a case study, thus evidencing the introduction of inherent safety features in layout design

  14. Application of approximate pattern matching in two dimensional spaces to grid layout for biochemical network maps.

    Science.gov (United States)

    Inoue, Kentaro; Shimozono, Shinichi; Yoshida, Hideaki; Kurata, Hiroyuki

    2012-01-01

    For visualizing large-scale biochemical network maps, it is important to calculate the coordinates of molecular nodes quickly and to enhance the understanding or traceability of them. The grid layout is effective in drawing compact, orderly, balanced network maps with node label spaces, but existing grid layout algorithms often require a high computational cost because they have to consider complicated positional constraints through the entire optimization process. We propose a hybrid grid layout algorithm that consists of a non-grid, fast layout (preprocessor) algorithm and an approximate pattern matching algorithm that distributes the resultant preprocessed nodes on square grid points. To demonstrate the feasibility of the hybrid layout algorithm, it is characterized in terms of the calculation time, numbers of edge-edge and node-edge crossings, relative edge lengths, and F-measures. The proposed algorithm achieves outstanding performances compared with other existing grid layouts. Use of an approximate pattern matching algorithm quickly redistributes the laid-out nodes by fast, non-grid algorithms on the square grid points, while preserving the topological relationships among the nodes. The proposed algorithm is a novel use of the pattern matching, thereby providing a breakthrough for grid layout. This application program can be freely downloaded from http://www.cadlive.jp/hybridlayout/hybridlayout.html.

  15. Application of approximate pattern matching in two dimensional spaces to grid layout for biochemical network maps.

    Directory of Open Access Journals (Sweden)

    Kentaro Inoue

    Full Text Available BACKGROUND: For visualizing large-scale biochemical network maps, it is important to calculate the coordinates of molecular nodes quickly and to enhance the understanding or traceability of them. The grid layout is effective in drawing compact, orderly, balanced network maps with node label spaces, but existing grid layout algorithms often require a high computational cost because they have to consider complicated positional constraints through the entire optimization process. RESULTS: We propose a hybrid grid layout algorithm that consists of a non-grid, fast layout (preprocessor algorithm and an approximate pattern matching algorithm that distributes the resultant preprocessed nodes on square grid points. To demonstrate the feasibility of the hybrid layout algorithm, it is characterized in terms of the calculation time, numbers of edge-edge and node-edge crossings, relative edge lengths, and F-measures. The proposed algorithm achieves outstanding performances compared with other existing grid layouts. CONCLUSIONS: Use of an approximate pattern matching algorithm quickly redistributes the laid-out nodes by fast, non-grid algorithms on the square grid points, while preserving the topological relationships among the nodes. The proposed algorithm is a novel use of the pattern matching, thereby providing a breakthrough for grid layout. This application program can be freely downloaded from http://www.cadlive.jp/hybridlayout/hybridlayout.html.

  16. Digital Learning Compass: Distance Education State Almanac 2017. Wisconsin

    Science.gov (United States)

    Seaman, Julia E.; Seaman, Jeff

    2017-01-01

    This brief report uses data collected under the U.S. Department of Education's National Center for Educational Statistics (NCES) Integrated Postsecondary Education Data System (IPEDS) Fall Enrollment survey to highlight distance education data in the state of Wisconsin. The sample for this analysis is comprised of all active, degree-granting…

  17. Dragonflies are biocontrol agents in Wisconsin cranberry marshes

    Science.gov (United States)

    Dragonflies (Order Odonata) are abundant predators that emerge in large hatch events each summer in Wisconsin cranberry marshes. They seem to be a potential group of biocontrol agents for pest management that may be influenced by the diversity found on the marsh. In fact, our evidence shows that dra...

  18. Southeastern Wisconsin Workplace Communication Project Curriculum Development Guide.

    Science.gov (United States)

    Frederick, Catherine; Huss-Lederman, Susan; Johnson, Jewelie

    The Southeastern Wisconsin Workplace Communication Project is a workplace English-as-a-Second-Language (ESL) resource and outreach program involving a partnership of businesses and adult educators in a rural area that has experienced an increase in new speakers of English in the manufacturing workforce. The guide provides workplace educators and…

  19. WEAKLY SYNCHRYRONIZED SUBPOPULATION DYNAMICS IN WISCONSIN FROGS AND TOADS

    Science.gov (United States)

    Spatial synchrony in population dynamics is a topic of increasing interest in basic and applied ecology. We used data from 18 years of frog and toad calling surveys conducted throughout Wisconsin to determine the level of intraspecific synchrony among survey sites, and the relat...

  20. On Farmers’ Ground: Wisconsin Dairy Farm Nutrient Management Survey Questionnaire

    Science.gov (United States)

    This questionnaire was used during quarterly, face-to-face interviews with the fifty-four Wisconsin dairy farmers who participated in the ‘On Farmers’ Ground’ nutrient management research project. It was designed to systematically and consistently compile information on herd size and composition, l...

  1. Quaternary Glacial Mapping in Western Wisconsin Using Soil Survey Information

    Science.gov (United States)

    Oehlke, Betsy M.; Dolliver, Holly A. S.

    2011-01-01

    The majority of soils in the western Wisconsin have developed from glacial sediments deposited during the Quaternary Period (2.6 million years before present). In many regions, multiple advances and retreats have left a complex landscape of diverse glacial sediments and landforms. The soils that have developed on these deposits reflect the nature…

  2. The Wisconsin experience with incentives for demand-side management

    International Nuclear Information System (INIS)

    Landgren, D.A.

    1990-01-01

    It has been noted that, within traditional regulatory frameworks for electric utilities, factors exist which discourage demand side management (DSM) and that there is a lack of positive incentives for DSM. Regulatory agencies should therefore make it possible for DSM measures to benefit from the same treatment as supply-side measures. The Wisconsin Public Service Commission (WPSC) has recognized this need and has adopted various measures accordingly. The need for efficiency incentives is described according to the particular experience of Wisconsin Electric concerning their recourse to a DSM incentive and according to new incentive models being tested in collaboration with other electricity suppliers in Wisconsin. The WPSC has concluded that the fact of considering the costs relating to DSM as expenses or capitalizing them within the rate base does not motivate the utility to promote DSM programs. The WPSC has thus decided to experiment with energy efficiency incentives in order to evaluate their eventual impact. The choice of the type of incentive had an objective of starting the process in an area where the lack of experience has created, from the regulatory point of view, a reticence on the part of utilities to engage in DSM programs. The WPSC has designed a variety of incentive models which have been adapted to each utility's own situation. Specific incentive programs developed for three Wisconsin utilities are reviewed

  3. Wisconsin's Infants and Toddlers. Publication #2015-17

    Science.gov (United States)

    Murphey, David; Cooper, Mae

    2015-01-01

    Wisconsin's infants and toddlers (defined as children less than three years old) are more than 200,000 in number. Seventy-one percent are white/non-Hispanic, and the largest minority group is Hispanic, at 12 percent. Black, Asian American, and American Indian infants and toddlers make up smaller percentages. To help states target policies related…

  4. 77 FR 16674 - Establishment of the Wisconsin Ledge Viticultural Area

    Science.gov (United States)

    2012-03-22

    .... All of the comments expressed support for the proposed Wisconsin Ledge viticultural area. TTB... label reference on a wine that indicates or implies an origin other than the wine's true place of origin... or other term identified as being viticulturally significant in part 9 of the TTB regulations, at...

  5. Skill Needs and Training Strategies in the Wisconsin Printing Industry.

    Science.gov (United States)

    Wisconsin Univ., Madison. Center on Wisconsin Strategy.

    A study examined the emerging skill needs in the Wisconsin printing industry, a key industry that provided the largest increase (more than 13,000 new jobs) in manufacturing employment in the state in the past decade. Eighteen interviews were conducted with industry personnel and production managers, union representatives, technical college…

  6. The stress analysis evaluation and pipe support layout for pressurizer discharge system

    International Nuclear Information System (INIS)

    Mao Qing; Wang Wei; Zhang Yixiong

    2000-01-01

    The author presents the stress analysis and evaluation of pipe layout and support adjustment process for Qinshan phase II pressurizer discharge system. Using PDL-SYSPIPE INTERFACE software, the characteristic parameters of the system are gained from 3-D CAD engineering design software PDL and outputted as the input date file format of special pipe stress analysis program SYSPIPE. Based on that, SYSPIPE program fast stress analysis function is applied in adjusting pipe layout , support layout and support types. According to RCC-M standard, the pipe stress analysis and evaluation under deadweight, internal pressure, thermal expansion, seismic, pipe rupture and discharge loads are fulfilled

  7. Layout Capacitive Coupling and Structure Impacts on Integrated High Voltage Power MOSFETs

    DEFF Research Database (Denmark)

    Fan, Lin; Knott, Arnold; Jørgensen, Ivan Harald Holger

    2016-01-01

    -to-layer coupling and the comparison of the layout impacts have not been well established. This paper presents modeling of parasitic mutual coupling to analyze the parasitic capacitance directly coupled between two on-chip metal wires. The accurate 3D field solver analysis for the comparable dimensions shows...... that the layer-to-layer coupling can contribute higher impacts than the well-known side-by-side coupling. Four layout structures are then proposed and implemented in a 0.18 µm partial SOI process for 100 V integrated power MOSFETs with a die area 2.31 mm2. The post-layout comparison using an industrial 2D...

  8. Mathematical programming models for solving in equal-sized facilities layout problems. A genetic search method

    International Nuclear Information System (INIS)

    Tavakkoli-Moghaddam, R.

    1999-01-01

    This paper present unequal-sized facilities layout solutions generated by a genetic search program. named Layout Design using a Genetic Algorithm) 9. The generalized quadratic assignment problem requiring pre-determined distance and material flow matrices as the input data and the continuous plane model employing a dynamic distance measure and a material flow matrix are discussed. Computational results on test problems are reported as compared with layout solutions generated by the branch - and bound algorithm a hybrid method merging simulated annealing and local search techniques, and an optimization process of an enveloped block

  9. Efficiency Optimization by Considering the High Voltage Flyback Transformer Parasitics using an Automatic Winding Layout Technique

    DEFF Research Database (Denmark)

    Thummala, Prasanth; Schneider, Henrik; Zhang, Zhe

    2015-01-01

    .The energy efficiency is optimized using a proposed new automatic winding layout (AWL) technique and a comprehensive loss model.The AWL technique generates a large number of transformer winding layouts.The transformer parasitics such as dc resistance, leakage inductance and self-capacitance are calculated...... for each winding layout.An optimization technique is formulated to minimize the sum of energy losses during charge and discharge operations.The efficiency and energy loss distribution results from the optimization routine provide a deep insight into the high voltage transformer designand its impact...

  10. An emergent computation approach to the problem of polygon layout with performance constraints

    Science.gov (United States)

    Huang, Zhendong; Xiao, Renbin

    2013-10-01

    We address the two-dimensional satellite irregular polygons layout problem (TDSIPLP). By mapping the layout problem to a physical system, we present a self-organization emergence algorithm (SEA) based on a multi-agent system (MAS). SEA uses information on the local energy of agents and neighborhood rules to guide interactions between the agents and the environment. System self-organization evolves at a microcosmic level and eventually yields a layout that meets the performance constraints for a satellite. Experiments show that SEA can provide much better performance than other optimization techniques, such as generalized simulated annealing (GSA).

  11. A case study of printing industry plant layout for effective production

    Science.gov (United States)

    Viswajit, T.; Teja, T. Ravi; Deepthi, Y. P.

    2017-07-01

    This paper presents the overall picture of the processes happening in printing industry. This research is aimed to improve the plant layout of existing plant. The travel time was reduced by relocating machinery. Relocation is based on systematic layout planning (SLP). The complete process of raw material entering the industry to dispatching of finished product is shown in 3-D Flow diagram. The process happening in each floor explained in detail using Flow Process chart. Travel time is reduced by 25% after modifying existing plant layout.

  12. Solving the wind farm layout optimization problem using random search algorithm

    DEFF Research Database (Denmark)

    Feng, Ju; Shen, Wen Zhong

    2015-01-01

    Wind farm (WF) layout optimization is to find the optimal positions of wind turbines (WTs) inside a WF, so as to maximize and/or minimize a single objective or multiple objectives, while satisfying certain constraints. In this work, a random search (RS) algorithm based on continuous formulation...... by expert guesses or other optimization methods, and as an optimization tool to find the optimal layout of WF with a certain number of WTs. A new strategy to evaluate layouts is also used, which can largely save the computation cost. This method is first applied to a widely studied ideal test problem...

  13. The use of active breathing control (ABC) to reduce margin for breathing motion

    International Nuclear Information System (INIS)

    Wong, John W.; Sharpe, Michael B.; Jaffray, David A.; Kini, Vijay R.; Robertson, John M.; Stromberg, Jannifer S.; Martinez, Alavro A.

    1999-01-01

    Purpose: For tumors in the thorax and abdomen, reducing the treatment margin for organ motion due to breathing reduces the volume of normal tissues that will be irradiated. A higher dose can be delivered to the target, provided that the risk of marginal misses is not increased. To ensure safe margin reduction, we investigated the feasibility of using active breathing control (ABC) to temporarily immobilize the patient's breathing. Treatment planning and delivery can then be performed at identical ABC conditions with minimal margin for breathing motion. Methods and Materials: An ABC apparatus is constructed consisting of 2 pairs of flow monitor and scissor valve, 1 each to control the inspiration and expiration paths to the patient. The patient breathes through a mouth-piece connected to the ABC apparatus. The respiratory signal is processed continuously, using a personal computer that displays the changing lung volume in real-time. After the patient's breathing pattern becomes stable, the operator activates ABC at a preselected phase in the breathing cycle. Both valves are then closed to immobilize breathing motion. Breathing motion of 12 patients were held with ABC to examine their acceptance of the procedure. The feasibility of applying ABC for treatment was tested in 5 patients by acquiring volumetric scans with a spiral computed tomography (CT) scanner during active breath-hold. Two patients had Hodgkin's disease, 2 had metastatic liver cancer, and 1 had lung cancer. Two intrafraction ABC scans were acquired at the same respiratory phase near the end of normal or deep inspiration. An additional ABC scan near the end of normal expiration was acquired for 2 patients. The ABC scans were also repeated 1 week later for a Hodgkin's patient. In 1 liver patient, ABC scans were acquired at 7 different phases of the breathing cycle to facilitate examination of the liver motion associated with ventilation. Contours of the lungs and livers were outlined when applicable

  14. Layout design process in conventional Brazilian supermarkets Proceso de formulación de layouts en supermercados convencionales en Brasil Processo de formulação de layouts em supermercados convencionais no Brasil

    Directory of Open Access Journals (Sweden)

    Ana Maria Machado Toaldo

    2010-12-01

    Full Text Available The importance of the layout is well known in the performance of supermarket companies. However since there are very few studies on the subject, this research sought to understand the layout design process in conventionally sized supermarkets in the South of Brazil. For this reason an exploratory study was carried out. The choice of this methodology was due to scarceness of accumulated and systematized knowledge. Data were collected by in-depth interviews with a layout supervisor and a store manager in three supermarket chains in the South of Brazil. Results confirm that layout has considerable influence on company performance. A variety of strategies is used by the companies in layouts to make the customer remain in the store longer, make his stay more enjoyable and consequently encourage spending thus bringing about greater profitability. Finally, a theoretical structure of design layout was proposed. The intention of this study is not to be definitive, but to shed light on the subject, which while important, has never been emphasized in marketing studies.Es evidente la importancia del layout en el desempeño de las empresas supermercadistas. Sin embargo, faltan estudios sobre el tema. Pensando en esa laguna, esta investigación tuvo el objetivo principal de entender como es el proceso de formulación de layouts en supermercados de porte convencional en el Sur brasileño. Para eso, se realizó un estudio exploratorio. La decisión de escoger esa metodología fue en consecuencia de la escasez de conocimiento acumulado y sistematizado. Los datos fueron obtenidos por medio de entrevistas en profundidad realizadas con dos informantes en tres redes supermercadistas del sur de Brasil: un supervisor de layout y un gerente de tienda. Los resultados muestran que el layout tiene mucha influencia en el desempeño de la empresa. Por su intermedio, utilizándose una serie de estrategias, las empresas buscan los siguientes objetivos: hacer con que el

  15. Informed Forces for Environmental Quality, Conference Proceedings (University of Wisconsin, Green Bay, Wisconsin, March 28-29, 1968).

    Science.gov (United States)

    Wisconsin Univ., Green Bay.

    To increase understanding of the dimensions of man's impact on his environment and the key issues involved in improving that environment through education and action was the goal of the environmental quality conference held at the University of Wisconsin, Green Bay, on March 28-29, 1968. Contained in this document are the conference…

  16. Genetic algorithm optimization for dynamic construction site layout planning

    Directory of Open Access Journals (Sweden)

    Farmakis Panagiotis M.

    2018-02-01

    Full Text Available The dynamic construction site layout planning (DCSLP problem refers to the efficient placement and relocation of temporary construction facilities within a dynamically changing construction site environment considering the characteristics of facilities and work interrelationships, the shape and topography of the construction site, and the time-varying project needs. A multi-objective dynamic optimization model is developed for this problem that considers construction and relocation costs of facilities, transportation costs of resources moving from one facility to another or to workplaces, as well as safety and environmental considerations resulting from facilities’ operations and interconnections. The latter considerations are taken into account in the form of preferences or constraints regarding the proximity or remoteness of particular facilities to other facilities or work areas. The analysis of multiple project phases and the dynamic facility relocation from phase to phase highly increases the problem size, which, even in its static form, falls within the NP (for Nondeterministic Polynomial time- hard class of combinatorial optimization problems. For this reason, a genetic algorithm has been implemented for the solution due to its capability to robustly search within a large solution space. Several case studies and operational scenarios have been implemented through the Palisade’s Evolver software for model testing and evaluation. The results indi­cate satisfactory model response to time-varying input data in terms of solution quality and computation time. The model can provide decision support to site managers, allowing them to examine alternative scenarios and fine-tune optimal solutions according to their experience by introducing desirable preferences or constraints in the decision process.

  17. Deciphering the Routes of invasion of Drosophila suzukii by Means of ABC Random Forest

    Science.gov (United States)

    Fraimout, Antoine; Debat, Vincent; Fellous, Simon; Hufbauer, Ruth A.; Foucaud, Julien; Pudlo, Pierre; Marin, Jean-Michel; Price, Donald K.; Cattel, Julien; Chen, Xiao; Deprá, Marindia; François Duyck, Pierre; Guedot, Christelle; Kenis, Marc; Kimura, Masahito T.; Loeb, Gregory; Loiseau, Anne; Martinez-Sañudo, Isabel; Pascual, Marta; Polihronakis Richmond, Maxi; Shearer, Peter; Singh, Nadia; Tamura, Koichiro; Xuéreb, Anne; Zhang, Jinping

    2017-01-01

    Abstract Deciphering invasion routes from molecular data is crucial to understanding biological invasions, including identifying bottlenecks in population size and admixture among distinct populations. Here, we unravel the invasion routes of the invasive pest Drosophila suzukii using a multi-locus microsatellite dataset (25 loci on 23 worldwide sampling locations). To do this, we use approximate Bayesian computation (ABC), which has improved the reconstruction of invasion routes, but can be computationally expensive. We use our study to illustrate the use of a new, more efficient, ABC method, ABC random forest (ABC-RF) and compare it to a standard ABC method (ABC-LDA). We find that Japan emerges as the most probable source of the earliest recorded invasion into Hawaii. Southeast China and Hawaii together are the most probable sources of populations in western North America, which then in turn served as sources for those in eastern North America. European populations are genetically more homogeneous than North American populations, and their most probable source is northeast China, with evidence of limited gene flow from the eastern US as well. All introduced populations passed through bottlenecks, and analyses reveal five distinct admixture events. These findings can inform hypotheses concerning how this species evolved between different and independent source and invasive populations. Methodological comparisons indicate that ABC-RF and ABC-LDA show concordant results if ABC-LDA is based on a large number of simulated datasets but that ABC-RF out-performs ABC-LDA when using a comparable and more manageable number of simulated datasets, especially when analyzing complex introduction scenarios. PMID:28122970

  18. Diversity and evolution of ABC proteins in mycorrhiza-forming fungi.

    Science.gov (United States)

    Kovalchuk, Andriy; Kohler, Annegret; Martin, Francis; Asiegbu, Fred O

    2015-12-28

    Transporter proteins are predicted to have an important role in the mycorrhizal symbiosis, due to the fact that this type of an interaction between plants and fungi requires a continuous nutrient and signalling exchange. ABC transporters are one of the large groups of transporter proteins found both in plants and in fungi. The crucial role of plant ABC transporters in the formation of the mycorrhizal symbiosis has been demonstrated recently. Some of the fungal ABC transporter-encoding genes are also induced during the mycorrhiza formation. However, no experimental evidences of the direct involvement of fungal ABC transporters in this process are available so far. To facilitate the identification of fungal ABC proteins with a potential role in the establishment of the mycorrhizal symbiosis, we have performed an inventory of the ABC protein-encoding genes in the genomes of 25 species of mycorrhiza-forming fungi. We have identified, manually annotated and curated more than 1300 gene models of putative ABC protein-encoding genes. Out of those, more than 1000 models are predicted to encode functional proteins, whereas about 300 models represent gene fragments or putative pseudogenes. We have also performed the phylogenetic analysis of the identified sequences. The sets of ABC proteins in the mycorrhiza-forming species were compared to the related saprotrophic or plant-pathogenic fungal species. Our results demonstrate the high diversity of ABC genes in the genomes of mycorrhiza-forming fungi. Via comparison of transcriptomics data from different species, we have identified candidate groups of ABC transporters that might have a role in the process of the mycorrhiza formation. Results of our inventory will facilitate the identification of fungal transporters with a role in the mycorrhiza formation. We also provide the first data on ABC protein-coding genes for the phylum Glomeromycota and for orders Pezizales, Atheliales, Cantharellales and Sebacinales, contributing to

  19. The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance.

    Science.gov (United States)

    Dermauw, Wannes; Van Leeuwen, Thomas

    2014-02-01

    About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics. The white gene turned out to encode the first well studied ABC transporter in arthropods. The ABC gene family is now recognized as one of the largest transporter families in all kingdoms of life. The majority of ABC proteins function as primary-active transporters that bind and hydrolyze ATP while transporting a large diversity of substrates across lipid membranes. Although extremely well studied in vertebrates for their role in drug resistance, less is known about the role of this family in the transport of endogenous and exogenous substances in arthropods. The ABC families of five insect species, a crustacean and a chelicerate have been annotated in some detail. We conducted a thorough phylogenetic analysis of the seven arthropod and human ABC protein subfamilies, to infer orthologous relationships that might suggest conserved function. Most orthologous relationships were found in the ABCB half transporter, ABCD, ABCE and ABCF subfamilies, but specific expansions within species and lineages are frequently observed and discussed. We next surveyed the role of ABC transporters in the transport of xenobiotics/plant allelochemicals and their involvement in insecticide resistance. The involvement of ABC transporters in xenobiotic resistance in arthropods is historically not well documented, but an increasing number of studies using unbiased differential gene expression analysis now points to their importance. We give an overview of methods that can be used to link ABC transporters to resistance. ABC proteins have also recently been implicated in the mode of action and resistance to Bt toxins in Lepidoptera. Given the enormous interest in Bt toxicology in transgenic crops, such findings will provide an impetus to further reveal the role of ABC transporters in arthropods. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  20. ABA, AAB and ABC renewal in taste aversion learning

    Directory of Open Access Journals (Sweden)

    Javier Nieto

    2012-01-01

    Full Text Available Existe evidencia de que los cambios en los estímulos ambientales afectan activamente la ocurrencia de la respuesta condicionada (RC. La renovación contextual o la reaparición de una RC extinguida se observa cuando se continúa la extinción de dicha respuesta en un contexto diferente. Se diseñaron dos experimentos con el propósito de evaluar la renovación contextual en un procedimiento de condicionamiento de aversión al sabor. En el Experimento 1, se analizó la renovación contextual ABA y AAB, mientras que el Experimento 2 se evaluó la renovación ABA, AAB y ABC. Ambos experimentos constaron de tres fases: adquisición, extinción y prueba. En ambos experimentos, la fase de adquisición se condujo en el Contexto A para todos los grupos y en ella, se inyectó i.p. Cloruro de Litio (LiCl a los sujetos inmediatamente después de que ingirieron una solución de sacarosa. En la fase de extinción, se expuso a los sujetos únicamente a la solución de sacarosa, sin la inyección. Los grupos AAB y AAA recibieron esta fase en el Contexto A, mientras que los sujetos de los grupos ABA y ABC la recibieron en el Contexto B. En la fase de prueba, se continúo la extinción. Los grupos ABA y AAA recibieron esta fase en el Contexto A, el grupo AAB en el contexto B, mientras el grupo ABC la recibió en un tercer contexto. Los resultados mostraron renovación de la aversión condicionada al sabor en los grupos ABA, AAB y ABC. Se analiza la relación de estos hallazgos con el modelo de recuperación de información de Bouton (1994.

  1. Effects of planar element formulation and numerical integration order on checkerboard material layouts

    CSIR Research Space (South Africa)

    Long, CS

    2009-01-01

    Full Text Available The effects of selected planar finite element formulations, and their associated integration schemes, on the stiffness of a checkerboard material layout are investigated. Standard 4-node bilinear elements, 8- and 9-node quadratic elements, as well...

  2. Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

    Directory of Open Access Journals (Sweden)

    Casper Hyttel Clausen

    2014-12-01

    Full Text Available This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 μm beads from 1 μm as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes of the new electrode layout. Good agreement was observed between the model and the obtained experimental results.

  3. An AI-based layout design system for nuclear power plants

    International Nuclear Information System (INIS)

    Fujita, Kikuo; Akagi, Shinsuke; Nakatogawa, Tetsundo; Tanaka, Kazuo; Takeuchi, Makoto.

    1991-01-01

    An AI-based layout design system for nuclear power plants has been developed. The design of the layout of nuclear power plants is a time-consuming task requiring expertise, in which a lot of machinery and equipment must be arranged in a plant building considering various kinds of design constraints, i.e. spatial, functional, economical etc. Computer aided layout design systems have been widely expected and the application of AI technology is expected as a promising approach for the synthesis phase of this task. In this paper, we present an approach to the layout design of nuclear power plants based on a constraint-directed search; one of the AI techniques. In addition, we show how it was implemented with an object-oriented programming technique and give an example of its application. (author)

  4. Navigating comics: an empirical and theoretical approach to strategies of reading comic page layouts

    Directory of Open Access Journals (Sweden)

    Neil eCohn

    2013-04-01

    Full Text Available Like the sequence of words in written language, comic book page layouts direct images into a deliberate reading sequence. Conventional wisdom would expect that comic panels follow the order of text: left-to-right and down—a Z-path—though several layouts can violate this order, such as Gestalt groupings of panels that deny a Z-path of reading. To examine how layouts pressure readers to choose pathways deviating from the Z-path, we presented participants with comic pages empty of content, and asked them to number the panels in the order they would read them. Participants frequently used strategies departing from both the traditional Z-path and Gestalt groupings. These preferences reveal a system of constraints that organizes panels into hierarchic constituents, guiding readers through comic page layouts.

  5. Change of the layout of an office of a metallurgical company: simple projects, big solutions.

    Science.gov (United States)

    Duarte, Luiz Carlos da Silva; Eckhardt, Moacir; da Motta, Giordano Paulo

    2012-01-01

    The posture, a good organization and the proper layout of the environment and workplaces have a positive influence on the income of an employee. To develop the work it is used a methodology that addressed the study phases of the theory involving the subject, description of the current situation, preparation of conceptions, choice of design, implementation and reporting of results. Through the project of "Change of the layout of an office of a metallurgical company" there was an intervention in these reported aspects providing improvements in the office, regarding ergonomic, layout, workplace and lighting issues, bringing welfare to the official, with the intent to improve its performance within the company and facilitating its actions, as the company's customer service. The results provided improvements in layout, in the workplace and especially in comfort for the human resources that perform their activities.

  6. Layout Optimization of Structures with Finite-size Features using Multiresolution Analysis

    DEFF Research Database (Denmark)

    Chellappa, S.; Diaz, A. R.; Bendsøe, Martin P.

    2004-01-01

    A scheme for layout optimization in structures with multiple finite-sized heterogeneities is presented. Multiresolution analysis is used to compute reduced operators (stiffness matrices) representing the elastic behavior of material distributions with heterogeneities of sizes that are comparable...

  7. Organizing vertical layout environments: a forward-looking development strategy for high-rise building projects

    Science.gov (United States)

    Magay, A. A.; Bulgakova, E. A.; Zabelina, S. A.

    2018-03-01

    The article highlights issues surrounding development of high rise buildings. With the rapid increase of the global population there has been a trend for people to migrate into megacities and has caused the expansion of big city territories. This trend, coupled with the desire for a comfortable living environment, has resulted in numerous problems plaguing the megacity. This article proposes that a viable solution to the problems facing megacities is to create vertical layout environments. Potential options for creating vertical layout environments are set out below including the construction of buildings with atriums. Further, the article puts forth suggested spatial organization of the environment as well as optimal landscaping of high-rise buildings and constructions for the creation of vertical layout environments. Finally, the persuasive reasons for the adoption of vertical layout environments is that it will decrease the amount of developed urban areas, decrease traffic and increase environmental sustainability.

  8. A spatial multi-objective optimization model for sustainable urban wastewater system layout planning.

    Science.gov (United States)

    Dong, X; Zeng, S; Chen, J

    2012-01-01

    Design of a sustainable city has changed the traditional centralized urban wastewater system towards a decentralized or clustering one. Note that there is considerable spatial variability of the factors that affect urban drainage performance including urban catchment characteristics. The potential options are numerous for planning the layout of an urban wastewater system, which are associated with different costs and local environmental impacts. There is thus a need to develop an approach to find the optimal spatial layout for collecting, treating, reusing and discharging the municipal wastewater of a city. In this study, a spatial multi-objective optimization model, called Urban wastewateR system Layout model (URL), was developed. It is solved by a genetic algorithm embedding Monte Carlo sampling and a series of graph algorithms. This model was illustrated by a case study in a newly developing urban area in Beijing, China. Five optimized system layouts were recommended to the local municipality for further detailed design.

  9. Navigating comics: an empirical and theoretical approach to strategies of reading comic page layouts.

    Science.gov (United States)

    Cohn, Neil

    2013-01-01

    Like the sequence of words in written language, comic book page layouts direct images into a deliberate reading sequence. Conventional wisdom would expect that comic panels follow the order of text: left-to-right and down - a "Z-path" - though several layouts can violate this order, such as Gestalt groupings of panels that deny a Z-path of reading. To examine how layouts pressure readers to choose pathways deviating from the Z-path, we presented participants with comic pages empty of content, and asked them to number the panels in the order they would read them. Participants frequently used strategies departing from both the traditional Z-path and Gestalt groupings. These preferences reveal a system of constraints that organizes panels into hierarchic constituents, guiding readers through comic page layouts.

  10. Study of LED layout in indoor visible light communication and performance analysis

    Science.gov (United States)

    Wang, Jiaan; Che, Ying; Wang, Xinlan; Guo, Linyang; Li, Jing

    2017-10-01

    Light emitting diodes(LED) could provide both illumination and data communication in indoor visible light communication(VLC) that owns the modulation bandwith from several from several MHz to seneral hundreds of MHz. The layout of LED plays an important role in maintaining a steady optical power distribution over the receiving plane. The existing rectangular LED layout does not provide a full coverage on the receiving plane leaving receiving optical power outage area, which in turn affects the best performance of the VLC system. This paper design a circular layout scheme of LED in 5mX5mX3m room based on the criterion of the illumination minimum mean square deviation. The influence of the distribution of the intensity of illumination with the radius of 1m and 1.5m,for including the wall reflection and not including the wall reflection, and make a comparison with rectangular LED layout of illumination distribution, when the number of LEDs with rectangular layout as same as circular layout. Including the number of LEDs are 4 and 16.For a specific simulation parameters as following:height of receiving plane is 0.85m,a single LEDs is composed of 60X60 LED chips, the parameters of a single chip is that transmitting power is 20mW,center luminous intensity is 0.73cd.semiangle at half power is 70deg.The parameters of concentrator is that photodiode area is 1cm2,photodiode responsivity is 0.4,field of view at the receiver is 85deg.Other parameters are that reflective index of concentrator is 1.5,reflectivity of wall is 0.8.Circular layout and rectangular layout are analyzed through simulation of the received optical power distribution, signal noise ratio distribution in non line of sight(including the wall reflection) and line of sight(not including the wall reflection),when the number of the LED is different. It is clear from the results that the received optical power distribution of non line of sight is better than line of sight, when the number of the LED are same, but

  11. Validation of the Data Consolidation in Layout Database for the LHC Tunnel Cryogenics Controls Upgrade

    CERN Document Server

    Tovar-Gonzalez, A; Blanco, E; Fortescue-Beck, E; Fluder, C; Inglese, V; Pezzetti, M; Gomes, P; Wolak, T; Dudek, M; Frassinelli, F; Drozd, A; Zapolski, M

    2014-01-01

    The control system of the Large Hadron Collider cryogenics manages over 34’000 instrumentation and actuator channels. The complete information on their characteristics and parameters can be extracted from a set of views on the Layout database, to generate the specifications of the control system; from these, the code to populate PLCs (Programmable Logic Controller) and SCADA (Supervisory Control & Data Acquisition) is automatically produced, within the UNICOS framework (Unified Industrial Control System). The Layout database is, since 2003, progressively integrating and centralizing information on the whole CERN Accelerator complex. It models topographical organization (layouts) as functional positions and relationships. After three years of machine operation, many parameters have been manually adjusted in SCADA and PLCs; they now differ from their original values in the Layout database. Furthermore, to accommodate the upgrade of the UNICOS Continuous Process Control package to version 6, some data stru...

  12. IC layout adjustment method and tool for improving dielectric reliability at interconnects

    Energy Technology Data Exchange (ETDEWEB)

    Kahng, Andrew B.; Chan, Tuck Boon

    2018-03-20

    Method for adjusting a layout used in making an integrated circuit includes one or more interconnects in the layout that are susceptible to dielectric breakdown are selected. One or more selected interconnects are adjusted to increase via to wire spacing with respect to at least one via and one wire of the one or more selected interconnects. Preferably, the selecting analyzes signal patterns of interconnects, and estimates the stress ratio based on state probability of routed signal nets in the layout. An annotated layout is provided that describes distances by which one or more via or wire segment edges are to be shifted. Adjustments can include thinning and shifting of wire segments, and rotation of vias.

  13. The Comparison of Layout Arrangements for the Material Flow Ordering Planning in Production Systems through Simulation Analysis

    Directory of Open Access Journals (Sweden)

    Mehmet AKSARAYLI

    2009-02-01

    Full Text Available Enterprises have to make suitable location planning to decrease their product cost and to increase their productivity in our time. The aim of this study is to compare the basic layout types used in arranging inside facility layout with each other by using simulation. Especially in this study, material handling times between machines and ratio of these times in total times were interested. First of all a new production system is designed to the basic layout types used in arranging inside facility layout. And then in the designed production system, machines are arranged for each machine layout types. Machine layout types are transferred to PROMODEL simulation software. Then with the results of analysis, material handling times of different machine layout types and ratio of material handling times in total production time were compared and the results obtained from this analysis were given after commented on this study.

  14. Site Layout of the proposed new Hadrons' Injector Chain at CERN

    CERN Document Server

    Baldy, J L; Evans, L; Garoby, R; Gerigk, F; Lindroos, M; López-Hernandez, L A; Maury, S; Poehler, M; Silari, M; Vretenar, M

    2008-01-01

    The replacement of almost all the LHC injector complex on the Meyrin-site of CERN (Linac2, PSB and PS) is planned within the next 10 years. The layout foreseen for the new accelerators is described in this paper, together with its compatibility with the existing experimental physics facilities. These machines can, after upgrade, supply with high beam power future physics facilities for radioactive ions and/or neutrinos. Their possible layout is also sketched in this document.

  15. REPOSITORY LAYOUT SUPPORTING DESIGN FEATURE NO.13 - WASTE PACKAGE SELF SHIELDING

    International Nuclear Information System (INIS)

    Owen, J.

    1999-01-01

    The objective of this analysis is to develop a repository layout, for Feature No. 13, that will accommodate self-shielding waste packages (WP) with an areal mass loading of 25 metric tons of uranium per acre (MTU/acre). The scope of this analysis includes determination of the number of emplacement drifts, amount of emplacement drift excavation required, and a preliminary layout for illustrative purposes

  16. A study on three dimensional layout design by the simulated annealing method

    International Nuclear Information System (INIS)

    Jang, Seung Ho

    2008-01-01

    Modern engineered products are becoming increasingly complicated and most consumers prefer compact designs. Layout design plays an important role in many engineered products. The objective of this study is to suggest a method to apply the simulated annealing method to the arbitrarily shaped three-dimensional component layout design problem. The suggested method not only optimizes the packing density but also satisfies constraint conditions among the components. The algorithm and its implementation as suggested in this paper are extendable to other research objectives

  17. Transport, mechanical and global migration data of multilayer copolyamide nanocomposite films with different layouts

    OpenAIRE

    Scarfato, P.; Garofalo, E.; Di Maio, L.; Incarnato, L.

    2017-01-01

    Transport, mechanical and global migration data concern multilayer food packaging films with different layouts, all incorporating a layered silicate/polyamide nanocomposite as oxygen barrier layer, and a low-density polyethylene (LDPE) as moisture resistant layer in direct contact with food. The data are related to ?Tuning of co-extrusion processing conditions and film layout to optimize the performances of PA/PE multilayer nanocomposite films for food packaging? by?Garofalo et al. (2017) [1]...

  18. Layout Design for a Low Capacity Manufacturing Line: A Case Study

    OpenAIRE

    De Carlo, Filippo; Arleo, Maria Antonietta; Borgia, Orlando; Tucci, Mario

    2013-01-01

    The layout re‐arrangement of fashion production lines realizing many small batches is rarely deployed according to well‐known engineering procedures. In fact, it would often appear too complex to call a plant engineer for the proper layout design of such small production lines. Rather, it is preferred to apply empirical methodologies when considering, generally, factory know‐how, general business needs, safety requirements, and so on. In the present work, the results of a fashion manufacturin...

  19. Multi-objective random search algorithm for simultaneously optimizing wind farm layout and number of turbines

    DEFF Research Database (Denmark)

    Feng, Ju; Shen, Wen Zhong; Xu, Chang

    2016-01-01

    A new algorithm for multi-objective wind farm layout optimization is presented. It formulates the wind turbine locations as continuous variables and is capable of optimizing the number of turbines and their locations in the wind farm simultaneously. Two objectives are considered. One is to maximize...... wind farm, the algorithm also obtains useful Pareto frontiers and provides a wide range of Pareto optimal layouts with different numbers of turbines for a real-life wind farm developer....

  20. Improvement of productivity in low volume production industry layout by using witness simulation software

    Science.gov (United States)

    Jaffrey, V.; Mohamed, N. M. Z. N.; Rose, A. N. M.

    2017-10-01

    In almost all manufacturing industry, increased productivity and better efficiency of the production line are the most important goals. Most factories especially small scale factory has less awareness of manufacturing system optimization and lack of knowledge about it and uses the traditional way of management. Problems that are commonly identified in the factory are a high idle time of labour and also small production. This study is done in a Small and Medium Enterprises (SME) low volume production company. Data collection and problems affecting productivity and efficiency are identified. In this study, Witness simulation software is being used to simulate the layout and the output is focusing on the improvement of layout in terms of productivity and efficiency. In this study, the layout is rearranged by reducing the travel time from a workstation to another workstation. Then, the improved layout is modelled and the machine and labour statistic of both, original and improved layout is taken. Productivity and efficiency are calculated for both layout and then being compared.