WorldWideScience

Sample records for winston sherrill

  1. 75 FR 38127 - Sherrill Furniture, Hickory White Furniture Division Hickory, NC; Including Workers of Hickory...

    Science.gov (United States)

    2010-07-01

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-64,867] Sherrill Furniture, Hickory White Furniture Division Hickory, NC; Including Workers of Hickory White Upholstery High Point, NC in Support of Sherrill Furniture Hickory White Furniture Division Hickory, NC; Amended Certification...

  2. El Paciente Winston Churchill

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2000-12-01

    Full Text Available

    El 24 de enero de 1965 moría Sir Winston Churchill, unos dos meses después de haber cumplido su nonagésimo aniversario y a los 9 días de haber entrado en coma por un tercer y último accidente cerebro vascular.

    Fue un hombre extraordinario, el mejor estadista que ha tenido Inglaterra y uno de los personajes
    más importantes del siglo XX.

    Fue longevo a pesar de su agitada existencia y de la presencia de muchas dolencias que le aquejaron, confirmando aquel dicho de que los más enfermos son los que más viven. Recordando el libro de Accoce “Los enfermos que nos gobiernan”, y habiendo visitado la casa de Chartwell en unas vacaciones en el Reino Unido, el académico Ricardo Rueda González se dedicó a investigar y a conseguir datos sobre la historia médica de Winston Spencer Churchill, logrando en medio de apuntes de aquí y de allá, y con la ayuda de personal de nuestra corporación, la elaboración de un estupendo libro con ese título, en buena hora publicado por la Universidad Javeriana.

    Sobra decir que esta muy bien escrita obra se la lee uno de un tirón, dado el estilo fácil del autor, lo bien documentada que está y el interesante anecdotario, pues la vida de este gigante de la raza humana fue una permanente anécdota. Dice el prologuista Alberto Dangond Uribe, experto en el tema, lo siguiente: “En el curso de esa larga vida, tan intensa y tan activa, la envoltura mortal de Winston Churchill atravesará con éxito, peligros innumerables, accidentes y enfermedades de diversa índole...

  3. Charles H. Winston and Confederate Sulfuric Acid

    Science.gov (United States)

    Reithmiller, Steven

    1995-07-01

    Sulfuric acid turned out to be one of the critical chemicals made in the South during the Civil War. It was necessary for the manufacture of mercury fulminate which was used in the production of percussion caps and sulfuric acid was used in the Daniells cell to produce electricity. Charles H. Winston, president of the Richmond Female Institute and later professor at the University of Richmond (VA) was instrumental in the establishment of a plant to manufacture sulfuric acid in Charlotte, North Carolina. His patent and method of manufacture plus the uses of sulfuric acid during the Civil War are discussed.

  4. Winston-Lutz Test: A quantitative analysis; Teste de Winston-Lutz: uma analise quantitativa

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Aline Garcia; Nandi, Dorival Menegaz; Saraiva, Crystian Wilian Chagas, E-mail: dnandi@gmail.com [Universidade Federal de Santa Catarina (UFSC), Florianopolis (Brazil); Instituto Federal de Santa Catarina (IFSC), Florianopolis (Brazil); Hospital do Coracao, Sao Paulo, SP (Brazil)

    2017-11-01

    Objective: Describe a method of quantitative analysis for the Winston-Lutz test. Materials and methods The research is a qualitative exploratory study. The materials used were: portal film; Winston- Lutz test tools and Omni Pro software. Sixteen portal films were used as samples and were analyzed by five different technicians to measure the deviation between the radiation isocenters and mechanic. Results: Among the results were identified two combinations with offset values greater than 1 mm. In addition, when compared the method developed with the previously studied, it was observed that the data obtained are very close, with the maximum percentage deviation of 32.5%, which demonstrates its efficacy in reducing dependence on the performer. Conclusion: The results show that the method is reproducible and practical, which constitutes one of the fundamental factors for its implementation. (author)

  5. Winston Churchill And The European Union

    Directory of Open Access Journals (Sweden)

    Troitiño David Ramiro

    2015-06-01

    Full Text Available Given Winston Churchill’s influence and achievement as a writer, historian, adventurer, soldier, artist, and politician, his participation in the European integration process is crucial to understanding the entire scope of the project in its origins. Churchill was a fundamental voice promoting the Franco-British Union, a promoter of the European Communities, and an active participant of the Congress of Europe, embryo of the Council of Europe. This article analyzes Churchill’s view of European integration through his political speeches, in particular those delivered in Zurich and in The Hague, his ideas about the League of Nations and the United Nations, his understanding of the British Empire, and the special relations between the UK and the USA. His participation in the process of uniting Europe in its early stages provides us with essential information about the original plans for the creation of a united Europe and understanding the traditional British approach to the EU, including the current position of the conservative government led by Cameron.

  6. NASCAR Winston Cup Race Results for 1975-2003

    Science.gov (United States)

    Winner, Larry

    2006-01-01

    Stock car racing has seen tremendous growth in popularity in recent years. We introduce two datasets containing results from all Winston Cup races between 1975 and 2003, inclusive. Students can use any number of statistical methods and applications of basic probability on the data to answer a wide range of practical questions. Instructors and…

  7. 76 FR 21034 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-04-14

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston..., applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on-site leased workers... employed on-site at the Winston- Salem, North Carolina location of Dell Products LP, Winston-Salem (WS- 1...

  8. Market Segmentation, Targeting, Dan Brand Positioning Dari Winston Premier Surabaya

    OpenAIRE

    Tania, Debby

    2014-01-01

    Sejak tahun 2012 mulai terasa bahwa bisnis properti mengalami kenaikan di Indonesia. Banyak masyarakat Indonesia berinvestasi pada properti karena dianggap aman dan menguntungkan. Sehingga muncul banyak produk properti baru di Indonesia. Perkembangan properti di Indonesia menjadi peluang besar bagi Agen Properti untuk dapat menjalankan bisnisnya. Winston Premier sebagai salah satu Agen properti di Surabaya Barat yang baru berdiri memerlukan strategi pemasaran yang tepat untuk digunakan guna b...

  9. STS-87 Mission Specialist Winston E. Scott suits up

    Science.gov (United States)

    1997-01-01

    STS-87 Mission Specialist Winston Scott dons his launch and entry suit with the assistance of a suit technician in the Operations and Checkout Building. This is Scotts second space flight. He and the five other crew members will depart shortly for Launch Pad 39B, where the Space Shuttle Columbia awaits liftoff on a 16-day mission to perform microgravity and solar research. Scott is scheduled to perform an extravehicular activity spacewalk with Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, during STS-87. He also performed a spacewalk on STS-72.

  10. 75 FR 55614 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-13

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston..., applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on-site leased workers... location of Dell Products LP, Winston-Salem (WS-1) Division. The Department has determined that on-site...

  11. 76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-01-14

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston... Adjustment Assistance on March 1, 2010, applicable to workers of Dell Products LP, Winston- Salem (WS-1... Carolina location of Dell Products LP, Winston-Salem (WS-1) Division. The Department has determined that on...

  12. 75 FR 56564 - Dell Products LP, Winston-Salem (WS-1) Division Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-16

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston..., applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on-site leased workers... location of Dell Products LP, Winston-Salem (WS-1) Division. The Department has determined that on-site...

  13. 75 FR 76040 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-12-07

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston... 1, 2010, applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on... of Dell Products LP, Winston-Salem (WS-1) Division. The Department has determined that on-site...

  14. 75 FR 57505 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-21

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,575] Dell Products LP, Winston..., applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on-site leased workers... location of Dell Products LP, Winston-Salem (WS-1) Division. The Department has determined that on-site...

  15. Winston Spencer Churchill. Sus Enfermedades y la Medicina de su Época.

    Directory of Open Access Journals (Sweden)

    Ricardo Rueda González

    2008-03-01

    El robusto y rosagante niño Winston fue bautizado en solemne ceremonia el 27 de diciembre de 1874 en la Capilla del Palacio de Blenheim, por el capellán de los duques, el Reverendo Henry Williams Lule y de inmediato fue entregado a la niñera Mrs. Elizabeth Anne Everest, quien se constituyó en su segunda mamá. Everest era una mujer inteligente y bondadosa que supo manejar con profundo cariño y habilidad a Winston hasta su edad adulta. Falleció de una peritonitis a los 68 años, en 1895 cuando su niño consentido contaba apenas con 21 años.

  16. Applying leadership qualities of great people to your department: sir winston churchill.

    Science.gov (United States)

    Gibson, Matthew; Weber, Robert J

    2015-01-01

    As pharmacy leaders develop health-system pharmacy services, it is important for them to understand successful leadership behaviors and apply them effectively to be successful in managing the challenges of health care. Directors can learn various skills from leaders both in and outside of pharmacy. Learning from these great leaders can provide pharmacy directors with guidance on how to shape various aspects of their leadership style. Winston Churchill is considered to be one of history's greatest leaders; without his leadership, the outcome of World War II may have been completely different. Leadership qualities that made him successful include the use of clear and simple communication, decisiveness, willingness to take risks and learn from failure, commitment to self-improvement, and the ability to inspire and lead others. This article describes these leadership characteristics displayed by Winston Churchill and discusses ways these qualities can be used effectively by today's pharmacy leaders in building patient-centered services.

  17. Applying Leadership Qualities of Great People to Your Department: Sir Winston Churchill

    Science.gov (United States)

    Gibson, Matthew; Weber, Robert J.

    2015-01-01

    As pharmacy leaders develop health-system pharmacy services, it is important for them to understand successful leadership behaviors and apply them effectively to be successful in managing the challenges of health care. Directors can learn various skills from leaders both in and outside of pharmacy. Learning from these great leaders can provide pharmacy directors with guidance on how to shape various aspects of their leadership style. Winston Churchill is considered to be one of history’s greatest leaders; without his leadership, the outcome of World War II may have been completely different. Leadership qualities that made him successful include the use of clear and simple communication, decisiveness, willingness to take risks and learn from failure, commitment to self-improvement, and the ability to inspire and lead others. This article describes these leadership characteristics displayed by Winston Churchill and discusses ways these qualities can be used effectively by today’s pharmacy leaders in building patient-centered services. PMID:25684804

  18. 75 FR 20033 - Winston-Salem Southbound Railway Company-Corporate Family Transaction Exemption-High Point...

    Science.gov (United States)

    2010-04-16

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Finance Docket No. 35338] Winston-Salem Southbound Railway Company--Corporate Family Transaction Exemption--High Point, Thomasville... under 49 CFR 1180.2(d)(3) for a transaction within a corporate family. Applicants state that HPTD will...

  19. Magnitudes of nearshore waves generated by tropical cyclone Winston, the strongest landfalling cyclone in South Pacific records. Unprecedented or unremarkable?

    Science.gov (United States)

    Terry, James P.; Lau, A. Y. Annie

    2018-02-01

    We delimit nearshore storm waves generated by category-5 Tropical Cyclone Winston in February 2016 on the northern Fijian island of Taveuni. Wave magnitudes (heights and flow velocities) are hindcast by inverse modelling, based on the characteristics of large carbonate boulders (maximum 33.8 m3, 60.9 metric tons) that were quarried from reef-front sources, transported and deposited on coral reef platforms during Winston and older extreme events. Results indicate that Winston's storm waves on the seaward-margin of reefs fringing the southeastern coasts of Taveuni reached over 10 m in height and generated flow velocities of 14 m s- 1, thus coinciding with the scale of the biggest ancient storms as estimated from pre-existing boulder evidence. We conclude that although Winston tracked an uncommon path and was described as the most powerful storm on record to make landfall in the Fiji Islands, its coastal wave characteristics were not unprecedented on centennial timescales. At least seven events of comparable magnitude have occurred over the last 400 years.

  20. Making Race in the New South: Mexican Migration and Race Relations in Winston-Salem, North Carolina

    OpenAIRE

    Jones, Jennifer Anne Meri

    2011-01-01

    In this dissertation, I investigate how race is produced by looking at the reception experiences of Afro and Mestizo Mexican migrants to the New South. Despite the fact that Afro and Mestizo Mexicans are both phenotypically and culturally distinct from one another, they now assert a shared racial identity as minorities and as Latinos. Based on ethnographic field work in Winston-Salem, North Carolina, I argue that pervasive discrimination due to status drives Mexicans to assert a minority iden...

  1. Organochlorine accumulation by Sentinel Mallards at the Winston-Thomas sewage treatment plant, Bloomington, Indiana

    Science.gov (United States)

    Custer, T.W.; Sparks, D.W.; Sobiech, S.A.; Hines, R.K.; Melancon, M.J.

    1996-01-01

    Farm-raised l2-month-old female mallards (Anas platyrhynchos) were released at the Winston-Thomas sewage treatment plant, Bloomington, Indiana. Five mallards were sacrificed at the start of the study and at approximately 10-day intervals through day 100. Concentrations of polychlorinated biphenyls (PCBs) in carcasses increased linearly with time of exposure and exceeded 16 mcg/g wet weight by day 100; PCBs in breast muscle exceeded 3.9 mcg/g by day 100. These PCB values are among the highest recorded for wild or sentinel waterfowl. PCB concentrations in breast muscle (26-523 mcg/g lipid weight) were 50-1,000 times greater than human consumption guidelines for edible poultry in Canada (0.5 mcg/g lipid weight) and 9-176 times greater than consumption guidelines for edible poultry in the United States (3.0 mcg/g lipid weight). Additionally, PCB concentrations in carcass and breast muscle exceeded the threshold of the Great Lakes Sport Fish Consumption Advisory 'do not eat' category (1.9 mcg/g wet weight) by day 20 and day 50, respectively. Hepatic cytochrome P450-associated monooxygenases including BROD (benzyloxyresorufin-O-dealkylase), EROD (ethoxyresorufin-O-dealkylase), and PROD (pentoxyresorufin-O-dealkylase) were induced over 5-fold compared to reference mallards. BROD, EROD, and PROD were each significantly correlated to total PCBs and to the toxicity of selected PCB congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2. FAKTOR-FAKTOR KEINGINAN PINDAH AGEN REAL ESTATE WINSTON DI SURABAYA

    Directory of Open Access Journals (Sweden)

    Antonius Ricky Hartono

    2015-01-01

    Full Text Available This research was conducted to determine the factors that affect the desire to mo­ve Winston real estate agent in Surabaya. The population in this study amounted to 149 people. The sample of this research used the method of sampling of incidental to the level of a 10% error. Sample of this research as many as 113 people. This research u­sed a quantitative approach. The technique of collecting data used questionnaires com­pleted by respondents. Methods of data analysis that was used by the analysis of the factor. Analysis of the factor was ordained by using program Statistical Package for the So­cial Science (SPSS which consists of two stages: a descriptive analysis and ex­trac­tion. The results of this research show that the factors which affect the desire to move were composed of factors of individual and organizational factors. Individual factors which are more dominant than the system factors of the organization.

  3. Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2016-01-01

    This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

  4. Studies in Teaching: 2015 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 25, 2015)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2015-01-01

    This document presents the proceedings of the 20th Annual Research Forum held June 25, 2015, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 21 action research papers: (1) History Lives! The Use of Simulations in a High School Social Studies Classroom (Lydia Adkins); (2) Using Francophone Music in the High…

  5. Studies in Teaching: 2017 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2017)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2017-01-01

    This document presents the proceedings of the 22nd Annual Research Forum held June 29, 2017, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 12 action research papers: (1) Using Captioned Video to Teach Listening Comprehension in a Spanish Classroom (Michelle Allen); (2) Multimodal Instruction: How Film…

  6. “R. J. Reynolds Industries Inc.” - Winston-Salem - Carolina del Norte – (EE. UU.

    Directory of Open Access Journals (Sweden)

    Odell, -

    1977-11-01

    Full Text Available This building is destined to house the head office of the Company and two of its subsidiaries. It has a total constructed surface of 46,500 m2 on 5 floors and a semi-basement, in a rectangle block of 240 m length and 35 m width, located on a 40,000 m2 lot. From an architectonic point of view, ít offers an interesting volume proportion, by making the basically rectangular shape more dynamic by means of modules, also rectangular, rotated 45° on the upper floor. Technically, it constitutes a considerable advance in the procedures used for energy conservation and accumulation, based on the treatment of façades with refractory insulated glass in which the technical and functional objectives are combined in an interesting and esthetic exterior. In addition to the office space for the 1,400 - 1,600 company employees, the building has a large cafetería with kitchen service incorporated, an auditorium and 2,000 parking spaces, as well as the basic mstailations.En el mes de diciembre de 1975, R. J. Reynolds Industries hizo público el propósito de la Organización de construir un edificio de oficinas para la centralización administrativa internacional, en Winston-Saiem, Carolina del Norte. Las razones aducidas se referían, principalmente, a las nuevas necesidades de espacio que surgieron a raíz de la diversificación de las actividades de la compañía en todo el mundo, adquiriendo las características de una corporación multinacional, con empresas que abarcan campos tan diferentes como el de transportes marítimos, petróleo, alimentación, productos del aluminio, tabacos, etc.

  7. NURE aerial gamma-ray and magnetic reconnaissance survey: Blue Ridge area, Greensboro NJ 17-12, Winston-Salem NJ 17-11, and Johnson City NJ 17-10 Quadrangles. Volume I. Narrative report

    International Nuclear Information System (INIS)

    1978-12-01

    As part of the Department of Energy (DOE) National Uranium Resource Evaluation (NURE) Program, LKB Resources, Inc. has performed a rotary-wing, reconnaissance high sensitivity radiometric and magnetic survey in the Blue Ridge area of Virginia, North Carolina, South Carolina, Kentucky, and Tennessee. Five (5) 1:250,000 scale NTMS quadrangles (Greensboro, Winston-Salem, Johnson City, Knoxville, and Charlotte) were surveyed. A total of 15,753 line miles (25,347 kilometers) of data were collected utilizing a Sikorsky S58 and S58T helicopter. Traverse lines were flown in an east-west direction at 3.0 mile (4.8 kilometer) spacing, with tie lines flown in a north-south direction at 12 mile (20 kilometer) spacing. The data were digitally recorded at 1.0 second intervals. The NaI terrestrial detectors used in this survey had a total volume of 2,154 cubic inches. The magnetometer employed was a modified ASQ-10 fluxgate system. This report covers the Greensboro, Winston-Salem, and Johnson City NTMS 1:250,000 scale quadrangles. The Knoxville and Charlotte NTMS 1:250,000 scale quadrangles are covered in a separate report. The radiometric data were normalized to 400 feet terrain clearance, and are presented in the form of computer listings on microfiche and as stacked profile plots. Profile plots are contained in Volume II of this report. A geologic interpretation of the radiometric and magnetic data is included as part of this report

  8. BASEMAP, WINSTON COUNTY AND INCORPORATED AREAS, ALABAMA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  9. Winston Churchill : "Tormihoiatus". Kapitulatsioonijuubelite aegu / Henno Rajandi

    Index Scriptorium Estoniae

    Rajandi, Henno

    2002-01-01

    "Tormihoiatus" lk. 96-105, Kapitulatsioonijuubelite aegu lk. 105-110. Järelsõna raamatule: Churchill, W. Tormihoiatus. Tallinn : Varrak, 1995 ja sissejuhatav artikkel W. Churchilli memuaaridele "Bordeaux' relvarahu" ajakirjas "Looming", 1990, nr. 6

  10. Winston Churchill and the Third Front

    Science.gov (United States)

    1988-04-01

    manoeuvre in which very often the enemy has found himself defeated by some novel expedient or device, some queer , swift, unexpected thrust or stratcgy...Like Turkey in south-east Europe, Russia , not Chiang’s China, would be the continental ally thiat could defeat Japan on land. As early as the ’Trident...persuade Russia to come in against her.’ 1 7 Now at Teheran, Stalin privately told Churchill and Roosevelt that the Soviet Union would enter the war

  11. DCS Terrain Submission for Winston County, AL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  12. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, Winston COUNTY, AL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  13. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, WINSTON COUNTY, ALABAMA AND INCORPORATED AREAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  14. Jón Þ. Þór: Winston S. Churchill ævisaga

    Directory of Open Access Journals (Sweden)

    Pétur Berg Matthíasson

    2014-12-01

    Full Text Available Í umsögn gagnrýnenda kemur meðal annars eftirfarandi fram: Það felast mörg tækifæri í svona bókum og maður getur séð fyrir sér heilan bókaflokk í þessum stíl. Það er hins vegar ljóst að þekking höfundar og ástríða á viðfangsefninu skilar bók sem allir ættu að lesa sem einhvern áhuga hafa á sögu og stjórnmálum.

  15. Learning To Lead: How Winston Churchill And George Marshall Harvested Their WWI Experience

    Science.gov (United States)

    2014-04-01

    wrote, “I recall crossing over to New York on the government ferry with nine of them, each with a bride . I never learned of the career of two of these... French and British artillery, the manufacture of tanks, and the complicated relations between the French , English, and Americans. These topics were...million of them overseas. Marshall had played a huge part in all of it. By the end of the war, the AEF was of comparable size to the British and French

  16. From hyperons to applied optics: open-quotes Winston Conesclose quotes during and after ZGS era

    International Nuclear Information System (INIS)

    Swallow, E.C.

    1994-01-01

    This paper discusses developments in light collection which had their origin in efforts to construct high performance gas Cerenkov detectors for precision studies of hyperon beta decays at the ZGS. The resulting devices, know generally as open-quotes compound parabolic concentrators,close quotes have found applications ranging from nuclear and particle physics experiments to solar energy concentration, instrument illumination, and understanding the optics of visual receptors. Interest in these devices and the ideas underlying them stimulated the development of a substantial new subfield of physics: nonimaging optics. This progression provides an excellent example of some ways in which unanticipated - and often unanticipatable - applied science and open-quotes practicalclose quotes devices naturally emerge from first-rate basic science. The characteristics of this process suggest that the term open-quotes spinoffclose quotes commonly used to denote it is misleading and in need of replacement

  17. Ship Shock Trial Modeling and Simulation of USS WINSTON S. CHURCHHILL (DDG 81)

    National Research Council Canada - National Science Library

    Schneider, Nathan

    2003-01-01

    ... in a severe shock environment. While these tests are extremely important in determining the vulnerabilities of a surface ship they require an extensive amount of preparation manhours, and money...

  18. "Can I Come in Here?" Winston's Discovery of Edge-of-School Spaces and Meaningful Literacy Engagement

    Science.gov (United States)

    Johnson, Latrise

    2014-01-01

    Literacy classrooms are places of tension in the shaping of literate identities for Black male students because of classroom and cultural mismatch, racialized literacy beliefs and deficit views of Black male literacy achievement. However, research on connections between students' out-of-school literacy and academic literacy participation tells a…

  19. Experiential Metafunctional Analysis of Winston S. Churchill's "Speech on Hitler's Invasion of the U.S.S.R."

    Science.gov (United States)

    Liping, Chen

    2014-01-01

    According to Halliday, it is language that enables human beings to form the impression of experience, which consists of "goings-on"--happening, doing, sensing, meaning and being and becoming, either internally and externally. This is the experiential metafunction. With the focus on Transitivity, a political discourse has been studied…

  20. From Mercury to Apollo: astronaut Alan Shepard reflects on life support and other space issues [interview by Winston Huff].

    Science.gov (United States)

    Shepard, A

    1995-01-01

    Alan Shepard was one of the original Mercury astronauts. He became the first American in space on May 5, 1961, in the Freedom 7 capsule, during a 15 minute suborbital trip reaching 115 miles altitude and 302 miles down the Atlantic tracking range. Grounded by an inner ear problem, he served as Chief of the Astronaut Office for several years. After an operation to correct the problem, he commanded the Apollo 14 moon mission in 1971. He retired as a Rear Admiral in 1974. Here, Alan Shepard offers his views on life support comedies and tragedies, going back to the moon, future drivers of the manned space flight program, the benefits of the space program, joint NASA and Russia missions, how his NASA experience affected his personal life, and the profitability of working with NASA.

  1. Studies in Teaching 1999 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 1999).

    Science.gov (United States)

    McCoy, Leah P., Ed.

    This publication presents a collection of research projects presented at the Annual Research Forum at Wake Forest University: "The Use of Group Work as an Effective Teaching Technique in Lower Level Spanish Classes" (James Blackburn); "What Are the Real Factors behind Student Motivation?" (Matthew Grey Burdick); "Can…

  2. A Study of Strategic Lessons Learned in Vietnam. Volume 7. The Soldier

    Science.gov (United States)

    1980-04-11

    Baskir and Strauss, Chance and Circumstance, p. 129. 44. See, for example, Robert Sherrill, Military Justice is to Justice as Military Music is to Music ...default. Ab the educacion and AFQT results seem to imply, the typical heroin user "had difficulty in verbalization which made it increasingly...Sherril:, Robert. Military Xustice is to Justice as Mil;tary Music is to Music . New York: Hai per arid Row, 1970. Shils, E. A. "Primary Groups in the

  3. How Did Winston S. Churchill’s Experience as a Prisoner of War during the Boer War Affect His Leadership Style and Career?

    Science.gov (United States)

    2011-06-10

    walking under Boer guard back towards the rest of the prisoners, a heavy rain began, reflecting Churchill‘s mood . He noted in his book that ironically...did not speak any indigenous languages; he had seventy-five pounds and a few chocolate bars in his pocket, no map or compass and three hundred

  4. 75 FR 20385 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2010-04-19

    ... Regarding Eligibility To Apply for Worker Adjustment Assistance Dell Products LP, Winston-Salem (WS-1..., applicable to workers of Dell Products LP, Winston- Salem (WS-1) Division, including on-site leased workers... were employed on-site at the Winston-Salem, North Carolina location of Dell Products LP, Winston-Salem...

  5. Dunkerque-Falklands: Due eventi storico-politici attraverso l'analisi linguistica dei discorsi di Winston Churchill e Margaret Thatcher (Dunkirk-Falklands: Two Historical-Political Events through the Linguistic Analysis of the Speeches of Winston Churchill and Margaret Thatcher).

    Science.gov (United States)

    Arcaini, Giovanna

    1988-01-01

    The political speech is a unique kind of document that reflects the socio-historic climate of its time. Two historical events (Dunkirk and the Falkland Islands Crisis) and a principal protagonist from each are discussed, and the speeches of these two individuals are analyzed in order to find similarities and differences, and to find their basic…

  6. Medline Plus

    Full Text Available ... 14/2013) Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston- ... Safety Issues Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston- ...

  7. Medline Plus

    Full Text Available ... Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 7/ ... 2014) Percutaneous Placement of a Pulmonary Valve (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 12/ ...

  8. 78 FR 21916 - Procurement List; Addition And Deletions

    Science.gov (United States)

    2013-04-12

    ...--Highlighters, Free-Ink, Flat NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC Contracting Activity: General Services Administration, New York, NY Computer Accessories NSN: 7045-01-483-7840--Screen...

  9. 76 FR 68322 - Changes in Flood Elevation Determinations

    Science.gov (United States)

    2011-11-04

    ...; The Baker, President, County (10-03- Herald-Mail. Washington County Board 2211P). of Commissioners... Kernersville News Kernersville, 134 East and The Winston- Mountain Street, Salem Journal. Kernersville, NC... Chestnut and The Winston- Street, Winston-Salem, Salem Journal. NC 27101. Oklahoma: Oklahoma City of...

  10. Relaxation of Summer Gasoline Volatility Standard for Florida and the Raleigh-Durham-Chapel Hill Area (Triangle Area) and the Greensboro/Winston-Salem/High Point Area (Triad Area) in North Carolina

    Science.gov (United States)

    The EPA is taking final action to relax the federal volatility (RVP) standard applicable to summer gasoline supplied to three areas in Florida and the Triangle and Triad Areas in North Carolina from 7.8 pounds per square inch (psi) to 9.0 psi.

  11. Relaxation of Summer Gasoline Volatility Standard for Florida and the Raleigh-Durham-Chapel Hill Area (Triangle Area) and the Greensboro/Winston-Salem/High Point Area (Triad Area) in North Carolina Additional Resources

    Science.gov (United States)

    Federal Registers and fact sheets about EPA approving a request from Florida to relax the federal Reid Vapor Pressure standard applicable to gasoline introduced into commerce in the Miami, Tampa and Jacksonville areas.

  12. Public Interest Waiver of American Iron and Steel Requirements to the Winston-Salem and Forsyth County City/County Utilities Commission for 30 Inch TR Flex Pipe Fittings

    Science.gov (United States)

    Product specific project waivers apply only to the specified product and proposed project referenced in the waiver. Any other project that wishes to use a similar product must apply for a separate waiver based on specific project circumstances.

  13. A Case-Based Approach to Creative Design

    Science.gov (United States)

    1993-10-05

    993). nd forgetting are integrated through chine Learning fl: An Artificialintelligence Approach. Morgam metiognitive analysis. Experimental results in...and Exercises. ArtificialIntelligence , 19(3):321-350, 1982. [Winston, 19861 P. Winston. Learning by Augmenting Rules and Accumulating Censors

  14. 76 FR 34064 - Procurement List; Proposed Additions

    Science.gov (United States)

    2011-06-10

    ... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Proposed Additions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed..., Party, Birthday, Sports-Theme, 8pc. NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC...

  15. The Basket Girl, Limbe: Popular 116 Book review

    African Journals Online (AJOL)

    child who had come to mean much to her, lonely Margaret blackmails Winston so ruthlessly that eventually he commits suicide. The expression he is 'driven to suicide' suggests itself, but it has to be used with caution because Winston settles himself behind the wheel of his car and speeds to his death. And because· it ...

  16. Medline Plus

    Full Text Available ... Hospital, Greenville, SC, 6/14/2013) Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston-Salem, NC, ... SC, 10/22/2012) Safety Issues Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston-Salem, NC, ...

  17. 76 FR 29797 - Westpoint Home, Inc., New York Corporate Sales Office, New York, NY, Including Employees Working...

    Science.gov (United States)

    2011-05-23

    ... Home, Inc., Plano, TX Sales Office, Plano, TX; Westpoint Home, Inc., Daleville, IN Sales Office... the subject firm: Plano, Texas; Daleville, Indiana; Rogers, Arkansas; and Winston-Salem, North... Sales Offices in Plano, Texas, Daleville, Indiana, Rogers, Arkansas, and Winston-Salem, North Carolina...

  18. Communication beyond the Classroom. Dimension 2010. Selected Proceedings of the 2010 Joint Conference of the Southern Conference on Language Teaching, the Foreign Language Association of North Carolina, the North Carolina Chapter of AATSP, and the National Network of Early Language Learning

    Science.gov (United States)

    Cherry, C. Maurice, Ed.; Wilkerson, Carol, Ed.

    2010-01-01

    "Dimension" is the annual volume containing the selected, refereed, edited Proceedings of each year's conference. "Communication Beyond the Classroom" was the announced theme of the annual conference of the Southern Conference on Language Teaching (SCOLT), held April 15-17, 2010, at the Winston-Salem Marriott in Winston-Salem,…

  19. Communication beyond the Classroom: Dimension 2010. A Thematic Index of "Dimension," 1980-2009. Selected Proceedings of the 2010 Joint Conference of the Southern Conference on Language Teaching, the Foreign Language Association of North Carolina, the North Carolina Chapter of AATSP, and the National Network of Early Language Learning

    Science.gov (United States)

    Cherry, C. Maurice, Comp.; Wilkerson, Carol, Comp.

    2010-01-01

    "Dimension" is the annual volume containing the selected, refereed, edited Proceedings of each year's conference. The Southern Conference on Language Teaching (SCOLT), held its annual conference April 15-17, 2010, at the Winston-Salem Marriott in Winston-Salem, North Carolina, in collaboration with the Foreign Language Association of…

  20. "Beowulf" : Hollywood seikleb pimedas keskajas / Riho Laurisaar

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2007-01-01

    Anglosaksi eeposest "Beowulf", mille alusel on valminud USA seiklusfilm, millest suur osa on loodud arvutigraafika abil ( stsenarist Neil Gaiman, režissöör Robert Zemeckis, osades Anthony Hopkins, Angelina Jolie, Ray Winstone)

  1. Supermani esiisa / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Anglosaksi eepose "Beowulf" alusel on valminud samanimeline USA seiklusfilm : stsenaristid Neil Gaiman, Roger Avary : režissöör Robert Zemeckis : osades Anthony Hopkins, Angelina Jolie, Ray Winstone

  2. Medline Plus

    Full Text Available ... Center, Merriam, KS, 10/17/2012) Liver Cancer Segment V Liver Resection (University of Arizona Medical Center, ... Winston-Salem, NC, 1/15/2009) Liver Cancer Segment V Liver Resection (University of Arizona Medical Center, ...

  3. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital Center, Miami, FL, 12/4/2013) Surgical Weight Loss: Sleeve Gastrectomy (St. Francis Health ...

  4. 78 FR 28023 - National Vaccine Injury Compensation Program; List of Petitions Received

    Science.gov (United States)

    2013-05-13

    ... A. Bambalis, Winston-Salem, North Carolina, Court of Federal Claims No: 09-0543V. 261. Chloe Sampley... Chloe Authement, Lake Charles, Louisiana, Court of Federal Claims No: 09- 0887V. 432. Jacquie Nygren...

  5. Raamaturappija / Karl Martin Sinijärv

    Index Scriptorium Estoniae

    Sinijärv, Karl Martin, 1971-

    1996-01-01

    Tubli lapse tunnikell / Tekst Leelo Tunglalt; Groom, Winston. Gump & Co; Higgins, Jack. Soolo; Winter, Arno. Sodila ehk abiks tagumises pingis igavlejale; Murphy, Warren ja Shapir, Richard. Remo Special - Vastulöök

  6. Medline Plus

    Full Text Available ... Hospital, New York, NY, 1/04/2012) Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New ... Winston-Salem, NC, 09/17/2015) Seniors Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New ...

  7. Medline Plus

    Full Text Available ... Center, Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami ... Hospital Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami ...

  8. Medline Plus

    Full Text Available ... Eye Hospital, Birmingham, AL, 3/17/2014) Female Reproductive System Breast Reconstruction Breast Reconstruction: Deep Inferior Epigastric ... Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, Coral ...

  9. Medline Plus

    Full Text Available ... Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ... Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ...

  10. Medline Plus

    Full Text Available ... Mission Medical Center, Merriam, KS, 10/17/2012) Liver Cancer Segment V Liver Resection (University of Arizona ... Medical Center, Winston-Salem, NC, 1/15/2009) Liver Cancer Segment V Liver Resection (University of Arizona ...

  11. Medline Plus

    Full Text Available ... Forest University Baptist Medical Center, Winston-Salem, NC, 12/16/13) Transesophageal Echocardiogram (TEE) (Shawnee Mission Medical ... Broward Health Medical Center, Fort Lauderdale, FL, 5/12/2014) Total Ankle Replacement (Doctors Hospital, Coral Gables, ...

  12. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, ... York, NY, 2/24/2009) Metabolic Problems Genetic Brain Disorders Treating Moyamoya Disease (Children's Hospital Boston, Boston, ...

  13. Chasing U-Boats and Hunting Insurgents: Lessons from an Underhand Way of War

    National Research Council Canada - National Science Library

    Breemer, Jan S

    2006-01-01

    .... Winston Churchill, then the Royal Navy's political head, was not willing to go quite that far, yet at one point during World War I, he ordered that captured U-boat crews be treated as criminals, not prisoners of war...

  14. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, ... Erectile Dysfunction Simultaneous Inflatable Penile Prosthesis (IPP) and Male Sling Placement: Aiding in a Faster Return to ...

  15. 78 FR 42975 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Science.gov (United States)

    2013-07-18

    ..., Dietikon, SWITZERLAND; Koyo Electronics Industries Co., Ltd.; Tokyo, JAPAN; vMonitor, LLC, Abu Dhabi... to this venture. Also, Office FA.com Co., Ltd., Tochigi, JAPAN; and Salem Automation Inc., Winston...

  16. Empowering Minority Communities with Health Information - WSSU

    Energy Technology Data Exchange (ETDEWEB)

    McMurray, L. and W. Templin-Branner

    2010-11-10

    Environmental health focus with training conducted as part of the United Negro College Fund Special Programs Corporation/National Library of Medicine HBCU ACCESS Project at Winston-Salem State University, NC on November 10, 2010.

  17. 75 FR 60778 - Announcement of Funding Awards for Fiscal Year 2010 Historically Black Colleges and Universities...

    Science.gov (United States)

    2010-10-01

    ... University, 601 South Martin Luther King, Jr. Drive, Winston Salem, NC 27110. Grant: $800,000. 2. Benedict College, Dr. David Swinton, Benedict College, 1600 Harden Street, Columbia, SC, 29204-1086. Grant: $800...

  18. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Ovarian Cancer Scarless Hysterectomy (Baptist Hospital, Miami, FL, 10/17/2013) Pituitary Tumors Transnasal Endoscopic Surgery for Skull-Based Tumors (Sentara ...

  19. A Bridge Over Troubled Waters: The Vital Role of Intelligence Sharing in Shaping the Anglo-American "Special Relationship"

    National Research Council Canada - National Science Library

    Clark, David B

    2008-01-01

    Speaking to an American audience in 1946, Winston Churchill articulated the British desire for a special relationship with America, coining a term which has continued to define the shifting vagaries...

  20. Inclusion of students with special education needs in physical education

    Directory of Open Access Journals (Sweden)

    Martin Kudláček

    2010-01-01

    Full Text Available The purpose of this article is to present phenomena of inclusive physical education from the point of view of needs of students with SEN, teachers from the point of view of support and university PE teacher preparation programs (PETE.Inclusion of students with special educational needs (SEN in physical education is in Czech Republic still marginal topic, although issues related to inclusive physical education are among key challenges of students with SEN, their teachers, parents and university departments preparing prospective teachers. In the area of support in inclusive PE we present the model of support in inclusive PE (Sherrill, 2004; Kudláček & Ješina, 2008 and in the area of PETE we present of key outcomes of project EIPET (Theoretical knowledge, competence and skills framework.

  1. A dream come true: being President of ASHRM.

    Science.gov (United States)

    Oppenberg, Andrew A

    2014-01-01

    During our 33rd Annual Conference of the American Society for Healthcare Risk Management, I had the absolute honor and privilege to thank our 2013 ASHRM board and staff along with the ASHRM membership. On behalf of the membership I extended heartfelt thanks for a job well done to our retiring board members, friends, and colleagues: Faye Shepherd, Ellen Grady-Venditti, Michael Midgley, and Immediate Past President Mary Anne Hilliard. Together, we welcomed 2014 ASHRM board members and witnessed the oath of office to Hala Helm, David Sine, and Sherrill Peters, along with President-Elect Ellen Grady-Venditti and our 2014 President Jacque Mitchell. © 2014 American Society for Healthcare Risk Management of the American Hospital Association.

  2. Using enteric pathogens to assess sources of fecal contamination in the Silurian Dolomite Aquifer: Preliminary results

    Science.gov (United States)

    Muldoon, Maureen A; Borchardt, Mark A.; Spencer, Susan K.; Hunt, Randall J.; Owens, David

    2018-01-01

    The fractured Silurian dolomite aquifer is an important, but vulnerable, source of drinking water in northeast Wisconsin (Sherrill in Geology and ground water in Door County, Wisconsin, with emphasis on contamination potential in the Silurian dolomite, 1978; Bradbury and Muldoon in Hydrogeology and groundwater monitoring of fractured dolomite in the Upper Door Priority Watershed, Door County, Wisconsin, 1992; Muldoon and Bradbury in Assessing seasonal variations in recharge and water quality in the Silurian aquifer in areas with thicker soil cover. p 45, 2010). Areas underlain by the Silurian dolomite aquifer are extremely vulnerable to groundwater contamination from various land-use activities, especially the disposal of human wastewater and dairy manure. Currently there is no consensus as to which source of wastewater generates the greater impact to the aquifer.

  3. Bereday and Hilker: Origins of the "Four Steps of Comparison" Model

    Science.gov (United States)

    Adick, Christel

    2018-01-01

    The article draws attention to the forgotten ancestry of the "four steps of comparison" model (description--interpretation--juxtaposition--comparison). Comparativists largely attribute this to George Z. F. Bereday [1964. "Comparative Method in Education." New York: Holt, Rinehart and Winston], but among German scholars, it is…

  4. Familial Hemiplegic Migraine With ATP1A2 Mutations

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2007-05-01

    Full Text Available Three children with prolonged hemiplegia following severe unilateral headache and having mutations in ATP1A2 are reported from UCLA School of Medicine, Los Angeles, CA; University Children’s Hospital, Zurich, Switzerland; and Wake Forest University School of Medicine, Winston-Salem, NC.

  5. West African Journal of Radiology - Vol 10, No 1 (2003)

    African Journals Online (AJOL)

    Thyroid function in pregnant women with hyperemesis · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Winston C Ugbaja, Ifeoma J Okoye, 16-23. http://dx.doi.org/10.4314/wajr.v10i1.34193 ...

  6. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami ... Children's Hospital Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami ...

  7. Learning Guidelines and Algorithms for Types of Training Objectives

    Science.gov (United States)

    1976-03-01

    2) lower signal-to- doise ratios, (3) different amounts of time between signal presentations, (4) KOR on an intermittent time schedule, (5) specific...Iowa: William C. Brown-Co. 1972. pp. 1 95, 113, 146, 200, 201, 212. / Cagne. R. i. The Conditions of, Learning. Niew York: Holt. Pinehart, and Winston

  8. The Grief Account: Dimensions of a Contemporary Bereavement Genre

    Science.gov (United States)

    Dennis, Michael Robert

    2008-01-01

    The genre of the grief account is identified to include published narratives of surviving grief. Thematic analysis of Andrew Holleran's (2006) "Grief: A Novel," Lolly Winston's (2004) "Good Grief: A Novel," Joan Didion's (2005) "The Year of Magical Thinking," and J. Canfield and M. V. Hansen's (2003) "Chicken Soup for the Grieving Soul: Stories…

  9. Molluscan Evolutionary Development

    DEFF Research Database (Denmark)

    Wanninger, Andreas Wilhelm Georg; Koop, Damien; Moshel-Lynch, Sharon

    2008-01-01

    Brought together by Winston F. Ponder and David R. Lindberg, thirty-six experts on the evolution of the Mollusca provide an up-to-date review of its evolutionary history. The Mollusca are the second largest animal phylum and boast a fossil record of over 540 million years. They exhibit remarkable...

  10. An Analysis of the Relationship Between Control Discrimination Accuracy and Alcohol Abuse in the United States Air Force.

    Science.gov (United States)

    1986-08-01

    Holt, Rinehart, and Winston. Mahoney, M. J. (1977). Reflections on the cognitive-learning trend in psychotherapy . American Psycholoqist, 32, 5-13... Gestalt therapy. New York: Julian Press. Polich, J. M., & Orvis, B. R. (1979). Alcohol problems: Patterns and prevalence in the U. S. Air Force. Santa

  11. WHAT MIGHT HAVE BEEN

    African Journals Online (AJOL)

    twelve on her own, Hitler, in a megalomaniacal gesture, invaded Russia, so initiating what he himself would never allow to happen, making. Germany fight simultaneously on two fronts. Winston Churchill, within 24 hours of the invasion, with an equally magniloquent gesture, called. Russia a friend and ally, and pledged the ...

  12. New Fellows and Honorary Fellow

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1970 Honorary. Kock, Prof. Winston E. Date of birth: 5 December 1909. Date of death: 25 November 1982. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on ...

  13. Author Details

    African Journals Online (AJOL)

    Shakantu, Winston. Vol 23, No 1 (2016) - Articles Ineffective programme management on the delivery of health infrastructure projects: A case of the Northern Cape Abstract PDF · Vol 23, No 1 (2016) - Articles The contributions of construction material waste to project cost overruns in Abuja, Nigeria Abstract PDF · Vol 24, No ...

  14. Analysis of Market Factors Associatedwith Sales of Cut Natural Christmas Trees

    Science.gov (United States)

    Lawrence D. Garrett

    1977-01-01

    A study of the market performance of natural Christmas tree retailers in Winston-Salem, North Carolins, revealed that success was strongly related to location in active retail shopping areas. Christmas tree retailers in shopping centers or areas high in retail sales sold more trees, received a higher average price, and had fewer trees left unsold than retailers in...

  15. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 53 ... Vol 14, No 1 (2004), Adaptation of urban refugees in Uganda: a study of their socio-cultural and psychological well being in Kampala City, Abstract. Wilson Winstons ... Vol 14, No 1 (2004), An analysis of students' aspirations, expectations and gains in institutions of higher education in Zimbabwe, Abstract.

  16. Fort Hood Geographic Information System: Pilot System Development and User Instructions.

    Science.gov (United States)

    1983-05-01

    overlay operations is provided in the "Data Manipulation" Section of Chapter L 4. Figure 6 also illustrates each of these five operacions . When a new...Inc., UNIX Programmers Manual (Holt, Rinehart, and Winston, New York, 1983 and 1979). 29 -7 depending on whether that variable exists in that

  17. 75 FR 77666 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2010-12-13

    ..., Information Technology Department. 74,629 West Dermatology Medical Redlands, CA....... August 30, 2009.......... May 11, 2009. Inc. Negative Determinations for Worker Adjustment Assistance In the following cases... date 74,718 SecurAmerica, Workers On- Winston-Salem, NC.. Site at Dell Products LP. 74,930 Hotels.com...

  18. 77 FR 56809 - Foreign-Trade Zone 230-Piedmont Triad Area, North Carolina; Notification of Proposed Production...

    Science.gov (United States)

    2012-09-14

    ... Proposed Production Activity, Sonoco Corrflex (Kitting--Gift Sets), Rural Hall and Winston-Salem, NC The Piedmont Triad Partnership, grantee of FTZ 230, submitted a notification of proposed production activity on..., and in the ``Reading Room'' section of the Board's Web site, which is accessible via www.trade.gov/ftz...

  19. The Biological Effects of Nonionizing Radiation.

    Science.gov (United States)

    1981-12-29

    pathological tissues. Shear properties, such as shear viscosity, may become highly abnormal in diseases like psoriasis . The shear stresses are mainly...Forest University, Winston-Salem, NC LEGANDIJK, J.J.W. University Hospital, Utrecht, The Netherlands LEWIN, P.A. and CHIVERS, R.C. University of

  20. Evaluation of a Cultural Competence Intervention with Implications for the Nurse-Patient Encounter

    Science.gov (United States)

    Bradford, Althea Betty

    2012-01-01

    A short-term intervention on participants' knowledge of cultural competence was provided to 38 students in a baccalaureate nursing program at Winston-Salem State University (WSSU). The study examined the effectiveness of this intervention. Although WSSU is a Historically Black University, the majority of students in this program were White. Six…

  1. Fulltext PDF

    Indian Academy of Sciences (India)

    Echoing Winston Churchill one is tempted to say – never before have so few from such a small country done so much affecting so many! In this issue of Resonance we honour Wigner's life and work. After the pioneering steps taken by Henri Poincaré and Albert. Einstein in emphasizing the importance of symmetry and invari ...

  2. 78 FR 12238 - Approval and Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and...

    Science.gov (United States)

    2013-02-22

    ... include compressed natural gas and electric vehicles. d. Employee commute options programs. NC DENR... Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and Winston-Salem Carbon Monoxide... maintenance plan update for CO, showing continued attainment of the 8-hour CO National Ambient Air Quality...

  3. 78 FR 37118 - Approval and Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and...

    Science.gov (United States)

    2013-06-20

    ... the core maintenance area exists; c. alternative fuel vehicle programs to include compressed natural... Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and Winston-Salem Carbon Monoxide... (CO), showing continued attainment of the 8-hour CO national ambient air quality standard for the...

  4. representation without participation: an overview of local ...

    African Journals Online (AJOL)

    Admin

    One was the mentally-liberating impact of war- time experiences and propaganda on the colonial subjects. Particularly noteworthy in this respect was the third Clause of the Atlantic Charter by. Prime Minister Winston Churchill of Britain while explaining to the world why the Allied Forces were fighting the war against the Axis ...

  5. 62_311 - 317_CHM 021 Rukayyat

    African Journals Online (AJOL)

    userpc

    Keywords: Alkaloids, Corrosion, Inhibition,. INTRODUCTION. Corrosion is the destructive attack of a met by chemical or electrochemical reaction wit its environment, the corrosion of iron or iron base alloys with formation of corrosio products consisting largely of hydrous ferr oxide(Winston and Herbat, 2008). an alloy of iron ...

  6. Factors that influence Christmas tree sales

    Science.gov (United States)

    Thomas H. Pendleton; Lawrence D. Garrett

    1970-01-01

    An analysis of the metropolitan Christmas tree market in Winston-Salem, N. C., shows that to sell more trees, Christmas tree retailers should locate their lots on heavily traveled streets in business areas, have adequate parking facilities, advertise, and have attractive displays of trees. Retailers who follow these practices can expect to receive higher prices for...

  7. 278----9 Dec 2009 [FINAL VERSION].indd

    African Journals Online (AJOL)

    2009-12-09

    Dec 9, 2009 ... Bakhtin, M.M., 1984, Problems of Dostoyevsky's poetics, University of Minnesota Press, Minneapolis. Berlin, A., 2002, Lamentations: A commentary, Westminster John. Knox Press, Louisville. Vol. 65 No. 1 Page 7 of 7. 263. Brooks, C. & Warren, R.P., 1976, Understanding poetry, Holt,. Rinehart and Winston ...

  8. Medline Plus

    Full Text Available ... Roosevelt Hospital, New York, NY, 1/04/2012) Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ... Center, Winston-Salem, NC, 09/17/2015) Seniors Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ...

  9. Pop / Mart Kuldkepp

    Index Scriptorium Estoniae

    Kuldkepp, Mart

    2008-01-01

    Heliplaatidest: James "Hey Ma", Kelder "Vikerkaar ja latimeeria", David Torn "Lars and the Real Girl. Music from the motion picture", Tanel Ruben "Kogutud rikkus", Neon Neon "Stainless Style", 3 Doors Down "3 Doors Down", Winston Tong "In a Manner Of Speaking (Best Of)", Witch "Paralyzed"

  10. 78 FR 13742 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2013-02-28

    ... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0311] BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of..., Suite 700, Winston-Salem, NC 27101, a Federal Licensee under the Small Business Investment Act of 1958...

  11. 76 FR 55720 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2011-09-08

    ... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0311] BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of... 700, Winston-Salem, NC 27101, a Federal Licensee under the Small Business Investment Act of 1958, as...

  12. Planning for Organization Development in Operations Control Centers

    Science.gov (United States)

    2012-06-01

    OD. Action research, as first proposed by Kurt Lewin (1958) is a cyclical change process that brings scientists and practitioners together in a...Personality and Social Psychology, 37, 822-832. Lewin , K. (1958). Group decision and social change. New York: Holt, Rinehart, and Winston, pp. 201

  13. Isaac Newton

    CERN Document Server

    Westfall, Richard S

    2007-01-01

    Definitive, concise, and very interesting... From William Shakespeare to Winston Churchill, the Very Interesting People series provides authoritative bite-sized biographies of Britain's most fascinating historical figures - people whose influence and importance have stood the test of time. Each book in the series is based upon the biographical entry from the world-famous Oxford Dictionary of National Biography. -

  14. Long term storage of bee semen – A six month assessment of cryopreserved semen quality using motility as an index

    Science.gov (United States)

    Bee (Apis mellifera Linn.) spermatozoa is known for its ability to remain viable for at the least two years within the spermatheca as attested to by the queens’ continued laying of fertile eggs without remating over two to three (Woyke 1960; Winston 1987). However, the semen collected from the dron...

  15. 77 FR 77016 - Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets...

    Science.gov (United States)

    2012-12-31

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-69-2012] Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets); Rural Hall and Winston-Salem, North Carolina On August 20, 2012, the Piedmont Triad Partnership, grantee of FTZ 230, submitted a notification of...

  16. Medline Plus

    Full Text Available ... Winston-Salem, NC, 09/17/2015) Surgery and Rehabilitation Angioplasty Transradial Approach for Cardiac Catheterization: The New ... Hysterectomy (Baptist Hospital, Miami, FL, 10/17/2013) Knee Replacement Bi-Cruciate Stabilized (BCS) Total Knee System ( ...

  17. Bike Skills Training in PE Is Fun, Keeps Kids Safe

    Science.gov (United States)

    Wallace, Judi Lawson; Sutton, Nancy P.

    2015-01-01

    Incorporating bike skills into the elementary- and middle-school physical education curriculum encourages students to be physically active in a fun way while also learning bike safety skills. Winston-Salem's (NC) Safe Routes to School program demonstrates how collaboration with the public schools' health and physical education program can…

  18. Medline Plus

    Full Text Available ... 24/2009) Skin, Hair and Nails Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston-Salem, NC, 09/17/2015) Surgery and Rehabilitation Angioplasty Transradial Approach for Cardiac Catheterization: The New ...

  19. Structure of an urban Christmas tree market

    Science.gov (United States)

    Thomas H. Pendleton; Lawrence D. Garrett; Lawrence D. Garrett

    1973-01-01

    The retail Christmas tree market in Winston-Salem, N.C., was studied 3 years. Types of retailers and their sales are described. Best sales were made by dealers who had lots on heavily traveled streets in business districts, had ample parking facilities, advertised, and displayed their trees well.

  20. Chimamanda Ngozi Adichie's Half of a Yellow Sun : a symbolic ...

    African Journals Online (AJOL)

    ... rest of the world about this sarcastic fiasco. Sir Winston Churchill, the onetime British Prime Minister, refused presiding over the liquidation of the British empire, Biafra included, but Biafra succeeded in making a mockery of British's social sublimity and alienation in the person of Richard Churchill, the symbol of British fall.

  1. Developing Models to Forcast Sales of Natural Christmas Trees

    Science.gov (United States)

    Lawrence D. Garrett; Thomas H. Pendleton

    1977-01-01

    A study of practices for marketing Christmas trees in Winston-Salem, North Carolina, and Denver, Colorado, revealed that such factors as retail lot competition, tree price, consumer traffic, and consumer income were very important in determining a particular retailer's sales. Analyses of 4 years of market data were used in developing regression models for...

  2. Chopper GEN2 + Glyphosate efficacy for height classes of hardwood sprouts recolonizing six clearcut pine sites

    Science.gov (United States)

    Jimmie Yeiser; Andrew Ezell

    2015-01-01

    The purpose of this study was to assess sprout size as a determinant of subsequent control by a standard, single rate of imazapyr +glyphosate applied during site preparation. All study sites were in the hilly upper coastal plain of Mississippi (Winston or Oktibbeha Counties) or Louisiana (Sabine or Winn Parishes) and supported loblolly pine (Pinus taeda L.) plantations...

  3. CHIMAMANDA NGOZI ADICHIE'S HALF OF A YELLOW SUN: A ...

    African Journals Online (AJOL)

    Dean SPGS NAU

    SUN: A SYMBOLIC PRESENTATION OF THE BRITISH. FAILED MISSION IN BIAFRA. Ephraim Chukwu * http://dx.doi.org/10.4314/og.v12i 1.11. Abstract ... Richard as a word and/or a name stands for his unique self, but as representing everything British. The sameness of his surname as that of Sir Winston Churchill, the ...

  4. 76 FR 45267 - Determination That INVERSINE (Mecamylamine Hydrochloride) Tablet and Six Other Drug Products Were...

    Science.gov (United States)

    2011-07-28

    ...] Determination That INVERSINE (Mecamylamine Hydrochloride) Tablet and Six Other Drug Products Were Not Withdrawn..., Inc., 200 (mecamylamine East 1st St., Suite hydrochloride 300, Winston Salem, (HCl)) Tablet, 2.5 NC... (diclofenac Novartis sodium) Delayed- Pharmaceuticals Release Tablet, 75 Corp., One Health mg. Plaza, East...

  5. Effects of a College Adventure Orientation Program on Student Development Behaviors

    Science.gov (United States)

    Vlamis, Ekaterini; Bell, Brent J.; Gass, Michael

    2011-01-01

    This study examined the effects of an adventure orientation program on the student development behaviors of incoming first-year students at Hartwick College in Oneonta, New York. Student development was measured by a condensed version of the Student Development Task Inventory-2 (CSDTI-2; Gass, 1986; Winston, Miller, & Prince, 1979). Data…

  6. Geprogrammeerde onderrig: Skinner en Crowder se bydraes

    African Journals Online (AJOL)

    die beginsels van Sokrates, Comenius, Pesta- lozzi, sommige van Thorndike se wette, Kohn- ... voor 1700 toe Sokrates en Comenius van die belangrikste bydraers was. In die tydperk. 1700-1900 ..... tional Technology: Readings in Programmed Instruction,editor John P. de Cecco. London: Holt, Rinehart and Winston 1964, ...

  7. 76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

    Science.gov (United States)

    2011-05-11

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,900] CEVA Freight, LLC, Dell..., applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site leased workers from... workers employed at CEVA Freight, LLC, Dell Logistics Division, Winston-Salem, North Carolina who were...

  8. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ... Children's Hospital Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ...

  9. Research Paper ISSN 0189-6016©2008

    African Journals Online (AJOL)

    African J. TradCAM

    It is also used for dry coughs and gastric ulcers (Winston, 2004). Recent research indicates Shatavari enhances immune function, increases corticosteroid production, and promotes cell regeneration (Rege et al., 1999). In Thailand the root is claimed as a galactagogue, antidysenteric, antipeptic, antipruritic, antirheumatic,.

  10. The secret nominal life of Afrikaans intransitive adpositions

    African Journals Online (AJOL)

    Kate H

    In C. Leclère, É. Laporte, M. Piot and M. Silberztein (eds). Lexique syntaxe, et lexique-grammaire: papers in Honor of Maurice Gross. Amsterdam: Benjamins. pp. 253-275. Kiparsky, P. 1973. 'Elsewhere' in phonology. In S. Anderson and P. Kiparsky (eds). A festschrift for Morris Halle. New York: Holt, Rinehart and Winston.

  11. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, ... 10/28/2010) Knee System Utilizing Personalized Solutions Instrumentation (Woodwinds Health Campus, Woodbury, MN, 12/13/2013) ...

  12. Teste da caminhada de seis minutos em pacientes com DPOC durante programa de reabilitação Six minute walk test in COPD patients under a rehabilitation program

    Directory of Open Access Journals (Sweden)

    MARIA AUXILIADORA CARMO MOREIRA

    2001-11-01

    Full Text Available Objetivos: Relatar resultados obtidos em testes da caminhada de seis minutos (TC6 de pacientes com DPOC integrantes de programa de reabilitação pulmonar (PRP, com objetivo de contribuir para interpretação e adequada utilização deste teste. Paralelamente, estudar alguns fatores que interferem no treinamento físico durante a reabilitação pulmonar. Materiais e métodos: Foram avaliados, retrospectivamente, dados de 18 homens e cinco mulheres integrantes do PRP. Os pacientes foram submetidos a treinamento dos membros inferiores por três meses em três sessões por semana. Alguns parâmetros pré e pós-treinamento foram analisados: distância percorrida no TC6 e sua relação com os valores calculados pelas equações de Enright e Sherril para valores de referência, volume expiratório forçado no 1º segundo (VEF1, carga de treinamento, freqüência cardíaca (FC freqüência respiratória (f, saturação do oxigênio por oximetria (SpO2, índice de massa corpórea (IMC. Resultados: Os valores obtidos durante o TC6 pré-treinamento nos pacientes não diferiram dos de referência resultantes das equações de Enright e Sherril (p = 0,777. Houve diferença significativa nesses valores, após treinamento (p = 0,001. O aumento médio, na distância percorrida no TC6, após treinamento, foi de 76m; contudo, três pacientes não atingiram o aumento mínimo significativo de 54m. A distância percorrida, pós-treinamento correlacionou-se positivamente com o VEF1 pré-treinamento (p = 0,012, mas não com o incremento de carga durante o treinamento (p = 0,693. Não se observou diferença significativa na f, SpO2 no TC6 antes e após treinamento. A FC aumentou significantemente no final do TC6 após treinamento. Nove pacientes (39% apresentaram o IMC abaixo do limite inferior; destes, 6 (66% atingiram 54m ou mais de incremento na distância caminhada após treinamento. Conclusão: Sugere-se utilizar-se metodologia padronizada e adequada para

  13. Názory budoucích pedagogů na začlenění dětí s postižením do tělesné výchovy v Jihoafrické republice Attitudes of future physical educators toward teaching children with disabilities in physical education in the Republic of South Africa

    Directory of Open Access Journals (Sweden)

    Liz Bressan

    2007-02-01

    Full Text Available Jednou z bariér, týkající se začlenění dětí s postižením do tělesné výchovy, mohou být negativní postoje učitelů. Tyto postoje mohou pramenit z neznalosti nebo nedostatku zkušeností s dětmi s postižením. Pro překonání těchto bariér je nezbytné změnit postoje těch, kteří mají být prostředníky v inkluzi. Tripp a Sherrill (1991 opakovaně vyzdvihují význam postojů v aplikovaných pohybových aktivitách a jejich výzkumu. Teoreticky podložený výzkum o utváření postojů může stanovit rámec porozumění faktorům, které působí na vztah mezi postojem a chováním (Tripp & Sherrill, 1991. V rámci výzkumu postojů jsme upravili dotazník "Attitude Toward Teaching Individuals with Physical Disabilities in Physical Education" (ATIPDPE pro studenty oboru "sport science" na Universitě Stellenbosch v Jihoafrické republice. Do výzkumu bylo začleněno 60 studentů. Utvořili jsme dvě skupiny, ve kterých bylo 30 studentů se specializací trenérství osob se zdravotním postižením a 30 studentů bez této specializace. Porovnali jsme skupiny v komponentech teorie plánovaného jednání a výsledky ukázaly, že mezi postoji studentů v těchto dvou skupinách není statisticky významný rozdíl. The Republic of South Africa has undergone significant changes with regard to people with disabilities in the past number of years, which have also included changes in legislation and education. In the education of children with disabilities, inclusion is quite a new phenomenon. In order to prepare for inclusion, universities must focus on teacher preparation. Sherrill (1998 emphasised the role of attitudes in teacher preparation and therefore we have focused on the attitudes of university students toward inclusion. The aim of this study was to examine the differences in attitudes between two groups of students of the Department of Sport Science at the University of Stellenbosch in the Republic of South

  14. Overview of guidelines for the prevention and treatment of venous leg ulcers: a US perspective

    Directory of Open Access Journals (Sweden)

    White-Chu EF

    2014-02-01

    Full Text Available E Foy White-Chu,1 Teresa A Conner-Kerr2 1Oregon Health and Science University, Portland VA Medical Center, Portland, OR, 2Winston-Salem State University, Department of Physical Therapy, Winston Salem, NC, USA Abstract: Comprehensive care of chronic venous insufficiency and associated ulcers requires a multipronged and interprofessional approach to care. A comprehensive treatment approach includes exercise, nutritional assessment, compression therapy, vascular reconstruction, and advanced treatment modalities. National guidelines, meta-analyses, and original research studies provide evidence for the inclusion of these approaches in the patient plan of care. The purpose of this paper is to review present guidelines for prevention and treatment of venous leg ulcers as followed in the US. The paper further explores evidence-based yet pragmatic tools for the interprofessional team to use in the management of this complex disorder. Keywords: venous insufficiency, varicose ulcer, wound, compression bandages

  15. 78 FR 28626 - Te Connectivity, Industrial Division, Middletown, Pennsylvania; Te Connectivity, Corporate Shared...

    Science.gov (United States)

    2013-05-15

    ... Employment and Training Administration [TA-W-81,557; TA-W-81,557A; TA-W-81,557B; TA-W-81,557C; ;TA-W-81,557D..., Corporate Shared Services Group 100 & 200 Amp Drive, Harrisburg, Pennsylvania; Te Connectivity Corporate Shared Services Group, 3700 Reidsville Road, Winston-Salem, North Carolina; Te Connectivity, Corporate...

  16. Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab

    OpenAIRE

    Greenwood, Gregory T

    2015-01-01

    Gregory T Greenwood Nephrology Associates, PLLC, Winston-Salem, NC, USA Abstract: Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by chronic, uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy. Renal impairment and progression to end-stage renal disease are common in untreated patients with aHUS, and extrarenal manifestations are being increasingly characterized in the literature. Ocular involvement remains rare in aHUS. Thi...

  17. Breaching the Devil’s Garden: The 6th New Zealand Brigade in Operation Lightfoot. The Second Battle of El Alamein

    Science.gov (United States)

    2005-01-01

    Haifa, Winston Churchill directed General Bernard Law Montgomery to replace General Auchinleck because Churchill was dissatisfied with the latter’s...solutions remained on paper simply because there was insufficient time to implement them.󈧍 Generalmajor von Ravenstein , one of the commanders of...Romek A Narrative &_Pictorial History, by Richard Law and Craig Luther, R. James Bender Publishing, San Jose, California, page 190. H- Table prepared

  18. Coherent Structures in Plasmas Relevant to Electric Propulsion

    Science.gov (United States)

    2016-06-24

    Cappelli. "Excited state population dynamics of a xenon ac discharge." Plasma Sources Science and Technology 24, no. 5 (2015): 055013. 10. Frias, Winston...field and pressure gradients, which in turn, can induce large-scale gradient-driven instabilities forming plasma strictures such as spokes. The dynamics ...response is crucially sensitive to the dynamics along the magnetic field direction due to high velocity of electron thermal motion. On the contrary

  19. Evaluation of adipose-derived stem cells for tissue-engineered muscle repair construct-mediated repair of a murine model of volumetric muscle loss injury

    OpenAIRE

    Kesireddy, Venu

    2016-01-01

    Venu Kesireddy1,2 1Wake Forest Institute for Regenerative Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA; 2Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, USA Abstract: Volumetric muscle loss (VML) can occur from congenital defects, muscle wasting diseases, civilian or military injuries, and as a result of surgical removal of muscle tissue (eg, cancer), all of which can lead t...

  20. Evolve or Die: The U.S. Army’s Darwinian Challenge

    Science.gov (United States)

    2013-05-23

    social psychologist Dr. Kurt Lewin at the Massachusetts Institute of Technology’s (MIT) Research Center for Group Dynamics and his ground-breaking...Revolutions. 3rd ed. Chicago, IL.: University of Chicago Press, 1996. Lewin , Kurt . Group Decision and Social Change. New York: Holt, Rinehart and Winston...research in social and organizational psychology in the 1950s. Dr. Lewin postulated that transformation is a continual process of planning, action, and

  1. On Terrorism: An Analysis of Terrorism as a Form of Warfare

    Science.gov (United States)

    1987-09-01

    histories of Thucydides, Livy and Polybius and the military handbooks of Caesar , Frontinus and Vegetius.𔃽 Although the principles of war will be...For instance, Jules Loh has noted the effects of a small number of allegedly corrupt officials in a small, isolated Kentucky county.277 Sixteen...Balkans Since 14S3, p. 530. New York: Holt, Rinehart and Winston, 1958. Loh, Jules . "Big-Time Crime Hits Kentucky Hül Country," (Associated Press) San

  2. What Military Officers Need to Know About Civil-Military Relations

    Science.gov (United States)

    2012-04-01

    examples. During the Civil War, Abraham Lincoln constantly prodded George McClellan to take the offensive in Virginia in 1862. McClellan just as...such storied democratic war leaders as Winston Churchill and Abraham Lincoln “trespassed” on the military’s turf as a matter of course, influencing not...Inside Defense: Under- standing the 21st Century Military, ed. Derek Reveron and Judith Hicks Stiehm (New York: Macmillan, 2008). 7. See Mackubin Thomas

  3. Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema

    Directory of Open Access Journals (Sweden)

    Kaur R

    2014-12-01

    Full Text Available Ravdeep Kaur, Aerik Anthony Williams, Catherine Baker Swift, Jason W Caldwell Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NC, USA Abstract: Acquired angioedema is often associated with significant morbidity. An underlying lymphatic malignancy, autoimmune disorder, adenocarcinoma, or other malignancy may be present. Screening for these disorders should occur in all patients with acquired angioedema as treatment may result in resolution of angioedema. Keywords: complement, C1-INH deficiency, ecallantide, hemopathy

  4. The Wife of the First Term Enlisted Soldier: A Study of Socialization and Role

    Science.gov (United States)

    1989-02-01

    indicate that money problems have a negative effect on their marriage (a’though in two cases, the marriages manifest multiple problems). Finally, most women...are of Hispanic origin. In addition, one of the white respondents has an interracial marriage . At Fort Winston, we had no problem in reaching... effect on their marriage , describing tension and arguments centering about money. Finally, as seen at Grant, most women are optimistic - eight clearly

  5. Multicenter Clinical Trial of Keratin Biomaterial for Peripheral Nerve Regeneration

    Science.gov (United States)

    2012-10-01

    the issues associated w ith the use of autografts, nerve gui dance conduits have been developed to bridge the gap between the trans ected nerve ends...Biomaterial Hydrogel" Western North Carolina Society for Neuroscience : Winston-Salem, NC 11/2011; North Carolina Tissue Engineering and Regenerative...Technology Applications for Combat Casualty Care: St. Pete Beach, FL 8/2010; Society for Neuroscience : San Diego, CA 11/2010; Tissue Engineering and

  6. Ideology Has No Borders: Why We Need a Containment-Plus Strategy for the Islamic State

    Science.gov (United States)

    2015-04-01

    Deft Command of Varied Media 50 Brooking, The U.S. Government Should Pay Anonymous in Bitcoin to Fight ISIS 51 Francis, Why Don Draper Would Be...Government Should Pay Anonymous in Bitcoin to Fight ISIS. Foreign Policy, 3 March 2015. http://foreignpolicy.com/2015/03/03/the-u-s-government-should...pay-anonymous-in- bitcoin -to-fight-isis/ (accessed 7 March 2015). Churchill, Winston. The Sinews of Peace (Iron Curtain Speech). Westminster College

  7. Pointblank: Acts on the Eve of War, 1938-1939

    Science.gov (United States)

    2012-06-01

    Throughout this process, I kept my sanity by riding bikes and running with classmates, thanks fellas. The conversations at lunch were riveting and I was...alone provide the means of victory. Sir Winston Churchill The ominous noise of jet engines pierces a calm, late afternoon in the desert as the... self -escort when pursuit assets were unable to escort the bombers deep into enemy territory.12 The bomber was flexible and unafraid, but ACTS also

  8. A model of strategic marketing alliances for hospices: vertical, internal, osmotic alliances and the complete model.

    Science.gov (United States)

    Starnes, B J; Self, D R

    1999-01-01

    This article develops two previous research efforts. William J. Winston (1994, 1995) has proposed a set of strategies by which health care organizations can benefit from forging strategic alliances. Raadt and Self (1997) have proposed a classification model of alliances including horizontal, vertical, internal, and osmotic. In the second of two articles, this paper presents a model of vertical, internal, and osmotic alliances. Advantages and disadvantages of each are discussed. Finally, the complete alliance system model is presented.

  9. 1984 Program Report on the Army-Navy Initiative in the National Capital Area in Support of the Department of Defense Science and Engineering Apprenticeship Program for High School Students

    Science.gov (United States)

    1985-03-01

    Jennifer Vervier Conducted research to characterize Mentor: Robert Anderson the immune factor contained in the John Carroll High School coelonic...a local computer program. Oxon Hill Science and Technology Two experiments were using laser and Prince George’s County, Md. the third was a dense...Dr. D. Patrick blishing pathogenesis and persistance Winston Churchill High School of murine rotavirus . Montgomery County, Md. Leonard Lee Assisted in

  10. Staff Development, Deception Operations, and Force Projection: Lessons from the Normandy Invasion

    Science.gov (United States)

    2015-12-21

    Nazi Germany , it was not achieved without a considerable amount of planning. Popular history has ignored some of the key aspects of this operation...to the liberation of France and Europe from Nazi Germany , it was not achieved without a considerable amount of planning. Popular history has ignored...Winston Churchill A second conflict involving Germany in continental Europe was a concern for many military and political leaders during the

  11. Correlation Immunity, Avalanche Features, and Other Cryptographic Properties of Generalized Boolean Functions

    Science.gov (United States)

    2017-09-01

    duties due to Sailors, across the globe, who stand the watch. As Winston Churchill once said, “we sleep safely at night because rough men stand ready...Chapter 2 contains definitions and preliminary generalized Boolean function material. This is followed by Chapters 3–5, which contain the bulk of the...Generalized Boolean Functions Sic Parvis Magna Sir Francis DrakeA In this chapter we begin by covering some basic definitions and properties which we will make

  12. SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

    International Nuclear Information System (INIS)

    Kerns, J; Yaldo, D

    2016-01-01

    Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the time of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.

  13. SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Kerns, J [UT MD Anderson Cancer Center, Houston, TX (United States); Yaldo, D [Advocate Health Care, Park Ridge, IL (United States)

    2016-06-15

    Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the time of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.

  14. Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol

    Directory of Open Access Journals (Sweden)

    Vitolins MZ

    2018-04-01

    Full Text Available Mara Z Vitolins,1 L Douglas Case,1 Stephen R Rapp,2 Mark O Lively,3 Edward G Shaw,4 Michelle J Naughton,5 Jeffrey Giguere,6 Glenn J Lesser7 1Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; 6Greenville Community Oncology Research Program of the Carolinas, Greenville, SC, USA; 7Department of Internal Medicine-Hematology and Oncology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10 plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels.Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers. Participants were categorized by self-reported adherence; Kruskal–Wallis tests compared changes in alpha-tocopherol and CoQ10 levels between self-reported adherence groups.Results: Women (N=155 provided baseline and post-treatment biomarkers; 147 completed at least one diary. While changes in alpha-tocopherol and CoQ10 levels were moderately correlated, correlations ranged from 0.40 to 0.48, association between self-reported adherence and plasma alpha-tocopherol or CoQ10 levels was weak; correlations ranged from 0.10 to 0.29 at weeks 8, 16, and 24. Some participants with high self-reported adherence actually

  15. Accountability: a missing construct in models of adherence behavior and in clinical practice

    Directory of Open Access Journals (Sweden)

    Oussedik E

    2017-07-01

    Full Text Available Elias Oussedik,1 Capri G Foy,2 E J Masicampo,3 Lara K Kammrath,3 Robert E Anderson,1 Steven R Feldman1,4,5 1Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 4Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Piano lessons, weekly laboratory meetings, and visits to health care providers have in common an accountability that encourages people to follow a specified course of action. The accountability inherent in the social interaction between a patient and a health care provider affects patients’ motivation to adhere to treatment. Nevertheless, accountability is a concept not found in adherence models, and is rarely employed in typical medical practice, where patients may be prescribed a treatment and not seen again until a return appointment 8–12 weeks later. The purpose of this paper is to describe the concept of accountability and to incorporate accountability into an existing adherence model framework. Based on the Self-Determination Theory, accountability can be considered in a spectrum from a paternalistic use of duress to comply with instructions (controlled accountability to patients’ autonomous internal desire to please a respected health care provider (autonomous accountability, the latter expected to best enhance long-term adherence behavior. Existing adherence models were reviewed with a panel of experts, and an accountability construct was incorporated into a modified version of Bandura’s Social Cognitive Theory. Defining accountability and incorporating it into an adherence model will facilitate the development of measures of accountability as well

  16. An Arctic Republic of Letters in Early Twentieth-Century Canada

    Directory of Open Access Journals (Sweden)

    Christina Sawchuck

    2008-02-01

    Full Text Available The writing of historical polar exploration in the English-speaking academy has undergone a substantial shift in the past twenty years, to the point where it may be safe to declare that the once-dominant triumphal and hagiographical style, inherited from the nineteenth century, has breathed its last. The explorer as depicted in this tradition has become a figure of fun in current discourse, easily recognizable in the contours of caricature. Sherrill Grace, for example, presents for our inspection "courageous men battling a dangerous, hostile, female terra incognita to prove their masculinity and the superior force of their technology" whose fate is to "die nobly in struggle, or to map, claim, name, and control unstructured space, even if only on paper." It is all too simple to dismiss these aims in an era with less palpable sympathy for them. Instead, many current writers have chosen the more difficult approach of grounding these explorers in appropriate political, social, and cultural contexts, and subsequently uncovering the rationale behind their beliefs and practices.

  17. Microsoft Office Excel 2007 data analysis and business modeling

    CERN Document Server

    Winston, Wayne L

    2007-01-01

    Master the analysis and business modeling techniques that help you transform your data into bottom-line results. Award-winning business professor and corporate consultant Wayne Winston shares the best of his real-world experience in this practical guide-now updated for Excel 2007. Use Wayne's proven practices and hands-on exercises to help you work smarter, make better decisions, and gain the competitive edge. Solve real-world business problems with Excel 2007! Maximize profits-determine NPV, optimize your product mix, calculate ROICreate best, worst, and most-likely case scenarios for sal

  18. Concentrating lightguide for threshold Cherenkov counters

    International Nuclear Information System (INIS)

    Gavrishchuk, O.P.; Onuchin, V.A.; Semenov, V.K.; Suzdalev, V.I.

    1991-01-01

    A method of manufacturing lightguides (Winston lenses) is proposed to increase the effective area of light collection on photodetectors (with diameter of detectiving area from 45 to 120 mm) and to broaden angular range of radiation detection in threshold Cherenkov counters. The concentrating lightguides with height and diameter up to 300 mm were pressure formed of 3 to 5 mm thick plexiglass sheets. Dependences of the light reflection coefficient on the wavelength (for wavelengths between 185 and 650 nm) of the deposited lightguide are presented. 10 refs.; 4 figs

  19. Anatomic and physiopathologic changes affecting the airway of the elderly patient: implications for geriatric-focused airway management

    Directory of Open Access Journals (Sweden)

    Johnson KN

    2015-12-01

    Full Text Available Kathleen N Johnson,1 Daniel B Botros,1 Leanne Groban,1–4 Yvon F Bryan11Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Section on Molecular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USAAbstract: There are many anatomical, physiopathological, and cognitive changes that occur in the elderly that affect different components of airway management: intubation, ventilation, oxygenation, and risk of aspiration. Anatomical changes occur in different areas of the airway from the oral cavity to the larynx. Common changes to the airway include tooth decay, oropharyngeal tumors, and significant decreases in neck range of motion. These changes may make intubation challenging by making it difficult to visualize the vocal cords and/or place the endotracheal tube. Also, some of these changes, including but not limited to, atrophy of the muscles around the lips and an edentulous mouth, affect bag mask ventilation due to a difficult face-mask seal. Physiopathologic changes may impact airway management as well. Common pulmonary issues in the elderly (eg, obstructive sleep apnea and COPD increase the risk of an oxygen desaturation event, while gastrointestinal issues (eg, achalasia and gastroesophageal reflux disease increase the risk of aspiration. Finally, cognitive changes (eg, dementia not often seen as related to airway management may affect patient cooperation, especially if an awake intubation is required. Overall, degradation of the airway along with other physiopathologic and cognitive changes makes the elderly population more prone to complications related to airway management. When deciding which airway devices and techniques to use for intubation, the clinician should also consider the

  20. Virtual Interfaces: Research and Application (Les Interfaces Virtuelles entre Recherche et Applications).

    Science.gov (United States)

    1994-05-01

    AE.RE AR, provided the opportunity for in- (NASA) (NASA) (UK) (US A- yi creased fidelity have, in turn, .N11u(vegEtyt~v. 8-Oo1footor 1EDoirnt .1ti...representing knowledge" in P.H. WINSTON, 6diteur THE PSYCHOLOGY OF COMPUTER VISION, MC GRAW HILL, 1975. ( HWi 77) J. Wolf and W. Woods "The Hwim speech...Trans. Biomed. Eng., BME-38 - i.e. parallel to Y-Z plane (4), 366-378 14-9 6. J.C. Chung , M.R. Haris, F.P. Brooks, H. Fuchs, M.T. Kelley,J.Hughes

  1. Molluscan Evolutionary Development

    DEFF Research Database (Denmark)

    Wanninger, Andreas Wilhelm Georg; Koop, Damien; Moshel-Lynch, Sharon

    2008-01-01

    Brought together by Winston F. Ponder and David R. Lindberg, thirty-six experts on the evolution of the Mollusca provide an up-to-date review of its evolutionary history. The Mollusca are the second largest animal phylum and boast a fossil record of over 540 million years. They exhibit remarkable...... anatomical diversity and include the bivalves (scallops, oysters, and clams), gastropods (limpets, snails, and slugs), and cephalopods (squid, cuttlefish, and octopus). This study treats each major taxon and supplies general information as well as overviews of evolution and phylogeny using data from...... different sources--morphological, ultrastructural, molecular, developmental, and from the fossil record....

  2. Optical Materials, Adhesive and Encapsulant, III-V, and Optical Characterization Evaluation: Cooperative Research and Development Final Report, CRADA Number CRD-07-216

    Energy Technology Data Exchange (ETDEWEB)

    Kempe, M.

    2012-11-01

    SolFocus is currently developing solar technology for utility scale application using Winston collector based concentrating photovoltaics (CPV). Part of that technology development includes small mirror dishes and front surface reflectors, and bonding the separate parts to the assembly. Mirror panels must meet rigid optical specifications in terms of radius of curvature, slope errors and specularity. The reflective surfaces must demonstrate long term durability and maintain high reflectivity. Some bonded surfaces must maintain adhesion and transparency under high concentrations and high temperatures. Others will experience moderate temperatures and do not require transparency. NREL researchers have developed methods and tools that address these related areas.

  3. STS-72 Flight Day 7

    Science.gov (United States)

    1996-01-01

    On this seventh day of the STS-72 mission, the flight crew, Cmdr. Brian Duffy, Pilot Brent W. Jett, and Mission Specialists Leroy Chiao, Daniel T. Barry, Winston E. Scott, and Koichi Wakata (NASDA), awakened to music from the Walt Disney movie, 'Snow White and the Seven Dwarfs.' Chiao and Scott performed the second spacewalk of the mission where they tested equipment and work platforms that will be used in building the planned International Space Station. This spacewalk was almost seven hours long. Wakata conducted an interview with and answered questions from six graders from a Japanese school in Houston, Texas.

  4. An Analysis of the Effects Housing Improvements Have on the Retention of Air Force Personnel

    Science.gov (United States)

    1990-09-01

    s--’ : and :.±.you cn up paying up to $300 of non-reim.oursable mn’ ra contractor to clean it for you. He passes oty pc..t cs within ’the Houzing ...B074475L). Delaney, Robert F. "Washington Wrap" Defense Housing. Vol III No 5, Sep-Oct 89. Department of Defense. DOD 4165.63-M DOD Housing Management...Stuart W. Cook. Research Methods in Social Relations (Revised Edition). New York: Holt, Rinehart and Winston, 1964. Steel, Robert P., Ph.D., Class notes in

  5. Cardioprotection with adenosine: 'a riddle wrapped in a mystery'.

    Science.gov (United States)

    Przyklenk, Karin; Whittaker, Peter

    2005-07-01

    Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.

  6. Immersive Televisual Environments: Spectatorship, Stereoscopic Vision and the Failure of 3DTV

    Directory of Open Access Journals (Sweden)

    Ilkin Mehrabov

    2015-09-01

    Full Text Available This article focuses on one of the most ground-breaking technological attempts in creating novel immersive media environments for heightened televisual user experiences: 3DTV, a Network of Excellence funded by the European Commission 6th Framework Information Society Technologies Programme. Based on the theoretical framework outlined by the works of Jonathan Crary and Brian Winston, and on empirical data obtained from author’s fieldwork and laboratory visit notes, as well as discussions with practitioners, the article explores the history of stereoscopic vision and technological progress related with it, and looks for possible reasons of 3DTV’s dramatic commercial failure.

  7. Solar Mesosphere Explorer optical-mechanical systems engineering

    Science.gov (United States)

    Gause, K. A.; Stuart, J. R.

    1979-01-01

    Mission overview of the Solar Mesosphere Explorer is presented along with design analysis and summaries of results. The Solar Mesosphere Explorer is a spin stabilized satellite carrying a complement of four Ebert-Fastie spectrometers and a four-channel Mersenne radiometer. Description of the spectrometer is given including a telescope and its aberrations. The radiometer is also described with consideration given to isothermal and thermal design, a Winston paraboloid, and optical tolerances. These five instruments are for measuring the earth's ozone density and distribution and providing quantitative data about those processes which govern the formation and destruction of ozone.

  8. STS-87 Mission Specialists Scott and Doi with EVA coordinator Laws participate in the CEIT for their

    Science.gov (United States)

    1997-01-01

    Participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center are STS-87 crew members, assisted by Glenda Laws, extravehicular activity (EVA) coordinator, Johnson Space Center, at left. Next to Laws is Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, who is looking on as Mission Specialist Winston Scott gets a hands-on look at some of the equipment. The STS-87 mission will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks.

  9. A model of strategic marketing alliances for hospices: horizontal alliances.

    Science.gov (United States)

    Self, D R; Starnes, B J

    1999-01-01

    This article develops two previous research efforts. William J. Winston (1994, 1995) has proposed a set of strategies by which health care organizations can benefit from forging strategic alliances. Raadt and Self (1997) have proposed a classification model of alliances including horizontal, vertical, internal and osmotic. In the first of two articles, this paper presents a model of horizontal alliances. The subsets include transregional, service mergers, networks, venture capital investments, trade and professional organizations, and promotional alliances. Advantages and disadvantages of each are discussed.

  10. Negative muon spin precession measurement of the hyperfine states of muonic sodium

    International Nuclear Information System (INIS)

    Brewer, J.H.; Ghandi, K.; Froese, A.M.; Fryer, B.A.

    2005-01-01

    Both hyperfine states of muonic 23 Na and the rate R of conversion between them have been observed directly in a high field negative muon spin precession experiment using a backward muon beam with transverse spin polarization. The result in metallic sodium, R=13.7±2.2 μs -1 , is consistent with Winston's prediction in 1963 based on Auger emission of core electrons, and with the measurements of Gorringe et al. in Na metal, but not with their smaller result in NaF. In NaOH we find R=23.5±8 μs -1 , leaving medium-dependent effects ambiguous

  11. Europe from challenges of war towards challenges of peace

    OpenAIRE

    Fahredin Shabani; Ibrahim Gashi

    2017-01-01

    The end of the WWII, did not bring peace and harmony among the peoples of Europe and World as expected. Enmity of the war time created such a deep ditch, which could not be overcome for a short time. What’s more, even among the allies-winners of the war, friendship and cooperation did not last too long. Very soon, two-three years after the end of the war, Europe was separated by an iron curtain, as Winston Churchill, the British prime minister would call it. The shadow of this division, first...

  12. Collaboration can work--given the right commitment. Interview by Donald E.L. Johnson.

    Science.gov (United States)

    Preslar, L B

    1992-11-01

    Community health care networks require an unprecedented level of collaboration between hospitals and other providers. But how can hospitals that are steeped in a competitive mindset convert to a collaborative approach, especially if they have competed directly? In the following interview with Donald E.L. Johnson, editor and publisher of Health Care Strategic Management, Len B. Preslar Jr., president of The North Carolina Baptist Hospitals Inc., in Winston-Salem explains how to overcome impediments to collaboration. There is an increasing recognition by hospital leaders of the need to collaborate but a continuing underestimation of the time and energy needed to make it work.

  13. Aprimoramento da capacidade funcional de idosos submetidos a uma intervenção por isostretching Improvement of functional capacity among elderly people undergoing isostretching intervention

    Directory of Open Access Journals (Sweden)

    AR Carvalho

    2008-08-01

    Full Text Available OBJETIVO: Verificar o aprimoramento da capacidade funcional de idosos submetidos a uma intervenção por isostretching. MÉTODOS: Estudo composto por 39 idosos, de ambos os sexos, sedentários, clinicamente saudáveis, com idade média de 66,3±3,34 anos, divididos em dois grupos: controle (GC, n=19 e experimental (GE, n=20. O GE foi submetido à intervenção baseada no isostretching, classificado como um método postural, aplicada uma vez por semana, durante dez sessões. A capacidade funcional foi mensurada pelo teste de caminhada de seis minutos (TC6 em três momentos: após a avaliação de triagem (TC6 INI, um dia após a quinta sessão (TC6 INTER e um dia após a décima sessão (TC6 FIN. A distância predita, tida como valor de referência (TC6 REF, foi calculada a partir dos dados antropométricos dos sujeitos aplicados na fórmula de Enright & Sherrill. Os dados foram normalizados pelos valores de referência e as comparações inter e intragrupos foram feitas, respectivamente, pelo teste t não pareado e pela análise de variância (ANOVA medidas repetidas com teste post-hoc de Tukey, com α=0,05. RESULTADOS: Não houve diferença estatística no TC6 REF dos grupos. No GC, todas as medidas do TC6 foram significativamente menores do que o TC6 REF (p0,05, indicando melhora do desempenho neste grupo. CONCLUSÕES: O isostretching aumenta a capacidade funcional dos idosos, podendo ser este um recurso terapêutico viável para impedir efeitos deletérios do envelhecimento sobre a capacidade funcional.OBJECTIVE: To investigate the improvement in functional capacity among elderly people undergoing an isostretching intervention. METHODS: This study sample was composed of 39 elderly people of both genders who were sedentary, clinically healthy and aged 66.3±3.34 years. They were divided into two groups: control group (n=19 and experimental group (n=20. The experimental group underwent a ten-session intervention based on isostretching (which is

  14. Validação da bateria "Beck" de testes de habilidades para atletas brasileiros de "rugby" em cadeira de rodas Validation of beck battery of skills tests to Brazilian players of wheelchair rugby

    Directory of Open Access Journals (Sweden)

    José Irineu Gorla

    2011-09-01

    Full Text Available O "Rugby" em Cadeira de Rodas é uma modalidade praticada por sujeitos com tetraplegia ou tetra-equivalência, desde 2005 no Brasil, onde existem aproximadamente 10 equipes em atividade. A avaliação motora é um dos meios de controle do treinamento que possibilita conquistar avanços no planejamento. A bateria "Beck" de testes de habilidades (manejo de bola, precisão de passes, bloqueio, velocidade e passes de longa distância para atletas da modalidade foi desenvolvida nos EUA por Yilla e Sherrill (1998. O objetivo deste estudo foi analisar os critérios de autenticidade científica da bateria para a população de atletas brasileiros. Os resultados de duas avaliações com a bateria (teste e re-teste realizadas com 11 atletas (média de idade 27,59 ± 5,37 anos, tempo de lesão 8,19 ± 3,83 anos, foram registrados por três avaliadores, o que possibilitou a análise de objetividade, fidedignidade e consistência interna. Foram utilizadas as ferramentas ANOVA para análise de objetividade e, coeficiente de correlação intraclasse e teste t para análise de fidedignidade e consistência. Não foram encontradas diferenças entre os resultados dos diferentes avaliadores (valores de p variando de 0,45 a 1,00 e os valores de correlação intraclasse encontrados (variação de r de 0,78 a 0,99 permitem concluir que a bateria é consistente e fidedigna. Os resultados encontrados neste estudo são evidências de que os critérios de autenticidade científica para a bateria são satisfeitos e a bateria pode ser considerada um instrumento válido para avaliação motora de atletas brasileiros de "rugby" em cadeira de rodas.The Wheelchair Rugby is a sport practiced by subjects with tetraplegia or tetra-equivalence, since 2005 in Brazil, where there are approximately 10 teams in business. The motricity evaluation is a means of training control that allows achieve real progress in planning. The BECK battery of skills tests (ball handling, precision

  15. Reference Equation for Six Minute Walk Test in Healthy Western India Population.

    Science.gov (United States)

    Fernandes, Lalita; Mesquita, Anthony Menezes; Vadala, Rohit; Dias, Amit

    2016-05-01

    The Six Minute Walk Test (6MWT) is used to assess disease progression and survival in chronic cardiopulmonary disorders. However, variability is noted in the six minute walk test distance (6MWD) in different populations. We aimed to develop a reference equation for 6MWD in healthy Western India population and compare the results with previously published Indian and Caucasian reference equations. Total 174 healthy subjects between 25 to 75 years performed the 6MWT. Variables assessed were age, height, weight, body mass index and sex. Predicted equations were derived using multiple linear regression and compared with the equations for North Indian male, South Indian and Caucasian population using Bland - Altman method. The 6MWD mean (SD) was 512.38 (67.84) m for men and 457.27 (56.75) m for women with p=0.001. The 6MWD correlated with age (r=-0.44), height (r=0.43), weight (r=0.21) in univariate analysis. Stepwise multiple regression analysis showed age and sex to be independent predictors of 6MWD, R(2) =0.307. The reference equation for healthy Western India population is 553.289 + (-2.11 x age) + (45.323 x sex; men=1 and women =0). Bland Altman analysis showed that the mean bias was 50.87m (95% limits of agreement 134.77 to - 33.0) for North Indian male equation, 50.75m (95% limits of agreement 105.72 to - 4.22) for South Indian equation and 122.72m (95%limits of agreement 254.11 to - 8.67) for Enright and Sherrill's equation. The North Indian male, South Indian and Caucasian equations significantly over-estimated the predicted walk distance for our healthy population. Hence, there is a need to develop subgroup population specific reference equations.

  16. Orwell's Satirical View of Romantic Love in the Terrorized World of Nineteen Eighty-Four

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Besharati

    2017-09-01

    Full Text Available The beginning of twentieth century was accompanied with the prevailing current of technology in different aspects of human life. At first, it incited a positive stimulus which could build a utopian world on the advancement of technology. However, the bloody World Wars averted this view and the technological utopia was replaced by Orwellian dystopia. Orwell's Nineteen Eighty-Four is a satirical work which moves against Wells' utopian toward the reflection of a distorted technological society. Undoubtedly, satire is the best literary mode for dystopic depiction of the world specifically the one portrayed in Nineteen Eighty-Four. Winston Smith, the central character of this novel, is lower from his society in terms of intelligence and power of action. Therefore, he is put under rigid controls and brainwashing. And at last, he awfully rejects his love in favor the principles of the Party. Thus, in this study, we try to investigate Winston's romantic life in a satiric manner with respect to Northrop Frye's theme of romance which includes the three phase of agon, pathos and anagnorisis.

  17. A one-dimensional, steady-state, dissolved-oxygen model and waste-load assimilation study for Clear Creek, Monroe County, Indiana

    Science.gov (United States)

    Wilber, William G.; Crawford, Charles G.; Peters, J.G.; Girardi, F.P.

    1979-01-01

    A digital model calibrated to conditions in Clear Creek, Monroe County, IN, was used to develop alternatives for future waste loadings that would be compatible with Indiana stream water-quality standards defined for two critical hydrologic conditions, summer and winter low flows. The Winston Thomas wastewater-treatment facility is the only point-source waste load affecting the modeled reach of Clear Creek. A new waste-water-treatment facility under construction at Dillman Road (river mile 13.78) will replace the Winston Thomas wastewater-treatment facility (river mile 16.96) in 1980. Natural streamflow during the summer and annual 7-day, 10-year low flow is zero, so no benefit from dilution is provided. The model indicates that ammonia-nitrogen toxicity is the most significant factor affecting the stream water quality during summer and winter low flows. The ammonia-nitrogen concentration of the wastewater effluent exceeds the maximum total ammonia-nitrogen concentration of 2.5 milligrams per liter for summer months (June through August) and 4.0 milligrams per liter for winter months (November through March) required for Indiana streams. Nitrification, benthic-oxygen demand, and algal respiration were the most significant factors affecting the dissolved-oxygen concentration in Clear Creek during the model calibration. Nitrification should not significantly affect the dissolved-oxygen concentration in Clear Creek during summer low flows when the ammonia-nitrogen toxicity standards are met. (USGS)

  18. Quality assurance for a six degrees-of-freedom table using a 3D printed phantom.

    Science.gov (United States)

    Woods, Kyle; Ayan, Ahmet S; Woollard, Jeffrey; Gupta, Nilendu

    2018-01-01

    To establish a streamlined end-to-end test of a 6 degrees-of-freedom (6DoF) robotic table using a 3D printed phantom for periodic quality assurance. A 3D printed phantom was fabricated with translational and rotational offsets and an imbedded central ball-bearing (BB). The phantom underwent each step of the radiation therapy process: CT simulation in a straight orientation, plan generation using the treatment planning software, setup to offset marks at the linac, registration and corrected 6DoF table adjustments via hidden target test, delivery of a Winston-Lutz test to the BB, and verification of table positioning via field and laser lights. The registration values, maximum total displacement of the combined Winston-Lutz fields, and a pass or fail criterion of the laser and field lights were recorded. The quality assurance process for each of the three linacs were performed for the first 30 days. Within a 95% confidence interval, the overall uncertainty values for both translation and rotation were below 1.0 mm and 0.5° for each linac respectively. When combining the registration values and other uncertainties for all three linacs, the average deviations were within 2.0 mm and 1.0° of the designed translation and rotation offsets of the 3D print respectively. For all three linacs, the maximum total deviation for the Winston-Lutz test did not exceed 1.0 mm. Laser and light field verification was within tolerance every day for all three linacs given the latest guidance documentation for table repositioning. The 3D printer is capable of accurately fabricating a quality assurance phantom for 6DoF positioning verification. The end-to-end workflow allows for a more efficient test of the 6DoF mechanics while including other important tests needed for routine quality assurance. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  19. SU-E-T-234: Daily Quality Assurance for a Six Degrees of Freedom Couch Using a Novel Phantom

    Energy Technology Data Exchange (ETDEWEB)

    Woods, K; Woollard, J; Ayan, A; Sandu, A; Sommerfeld, J; Gupta, N [Ohio State Univ, Columbus, OH (United States); Laurel, A [Memorial Medical Center, Modesto, CA (United States)

    2015-06-15

    Purpose: To test the accuracy and reproducibility of both translational and rotational movements for a couch with six degrees of freedom (6DoF) using a novel phantom design Methods: An end-to-end test was carried out using two different phantoms. A 6 cm3 cube with a central fiducial BB (WL-QA Sun Nuclear) and a custom fabricated rectangular prism (31 cm x 8 cm x 8 cm), placed on a baseplate with known angular offsets for pitch, roll and yaw with a central fiducial BB and unique surface structures for registration purposes, were used. The end-to-end test included an initial CT simulation for a reference study, setup to an offset mark on each phantom, registration of the reference CT to the acquired cone-beam CT, and final Winston-Lutz delivery at four cardinal gantry angles. Results for both translational and rotational movements were recorded and compared for both phantoms. Results: Translational and rotational measurements were performed with a PerfectPitch (Varian) couch for 10 trials for both phantoms. Distinct translational shifts were [−5.372±0.384mm, −10.183±0.137mm, 14.028±0.155mm] for the cube and [7.520±0.159mm, −9.117±0.101mm, 16.273±0.115mm] for the prototype phantom for lateral, longitudinal, and vertical shifts, respectively. Distinct rotational adjustments were [1.121±0.102o, −1.067±0.235o, −2.662±0.380o] for the cube and [2.534±0.059o, 1.994±0.025o, 2.094±0.076o] for the prototype for pitch, roll, and yaw, respectively. Winston-Lutz test results performed after 6DoF couch correction from each cardinal gantry angle ranged from 0.26–0.72mm for the cube and 0.55–0.86mm for the prototype. Conclusion: The prototype phantom is more precise for both translational and rotational adjustments compared to a commercial phantom. The design of the prototype phantom allows for a more discernible visual confirmation of correct translational and rotational adjustments with the prototype phantom. Winston-Lutz results are more accurate for the

  20. SU-E-T-234: Daily Quality Assurance for a Six Degrees of Freedom Couch Using a Novel Phantom

    International Nuclear Information System (INIS)

    Woods, K; Woollard, J; Ayan, A; Sandu, A; Sommerfeld, J; Gupta, N; Laurel, A

    2015-01-01

    Purpose: To test the accuracy and reproducibility of both translational and rotational movements for a couch with six degrees of freedom (6DoF) using a novel phantom design Methods: An end-to-end test was carried out using two different phantoms. A 6 cm3 cube with a central fiducial BB (WL-QA Sun Nuclear) and a custom fabricated rectangular prism (31 cm x 8 cm x 8 cm), placed on a baseplate with known angular offsets for pitch, roll and yaw with a central fiducial BB and unique surface structures for registration purposes, were used. The end-to-end test included an initial CT simulation for a reference study, setup to an offset mark on each phantom, registration of the reference CT to the acquired cone-beam CT, and final Winston-Lutz delivery at four cardinal gantry angles. Results for both translational and rotational movements were recorded and compared for both phantoms. Results: Translational and rotational measurements were performed with a PerfectPitch (Varian) couch for 10 trials for both phantoms. Distinct translational shifts were [−5.372±0.384mm, −10.183±0.137mm, 14.028±0.155mm] for the cube and [7.520±0.159mm, −9.117±0.101mm, 16.273±0.115mm] for the prototype phantom for lateral, longitudinal, and vertical shifts, respectively. Distinct rotational adjustments were [1.121±0.102o, −1.067±0.235o, −2.662±0.380o] for the cube and [2.534±0.059o, 1.994±0.025o, 2.094±0.076o] for the prototype for pitch, roll, and yaw, respectively. Winston-Lutz test results performed after 6DoF couch correction from each cardinal gantry angle ranged from 0.26–0.72mm for the cube and 0.55–0.86mm for the prototype. Conclusion: The prototype phantom is more precise for both translational and rotational adjustments compared to a commercial phantom. The design of the prototype phantom allows for a more discernible visual confirmation of correct translational and rotational adjustments with the prototype phantom. Winston-Lutz results are more accurate for the

  1. Rainfall-Driven Diffusive Hydrograph and Runoff Model for Two Sub-Basins within the Arroyo Colorado in South Texas.

    Science.gov (United States)

    Ball, M. C.; Al-Qudah, O.; Jones, K.

    2017-12-01

    The Arroyo Colorado, located within the Rio Grande Valley of South Texas, has been on the list for the State of Texas's most impaired rivers since the 1990's. Few models for the watershed discharge and contaminates transport have been developed, but all require specialized understanding of modeling and input data which must either be assumed, estimated or which is difficult, time-consuming and expensive to collect. It makes sense to see if a general, simpler `catchment-scale' lumping model would be feasible to model water discharge along the Arroyo. Due to its simplicity and the hypothesized diffusive nature of the drainage in the alluvial floodplain deposits of the Arroyo watershed, the Criss and Winston model was chosen for this study. Hydrographs were characterized, clearly demonstrating that the discharge to the Arroyo is greatly affected by precipitation, and which provided clear rain events for evaluation: 62 rain events over a ten-year time span (2007 - 2017) were selected. Best fit curves using the Criss and Winston lag time were plotted, but better fitting curves were created by modifying the Criss and Winston lag time which improved the fit for the rising limb portion of the hydrograph but had no effect on the receding limb portion of the graph. This model provided some insights into the nature of water transport along the Arroyo within two separate sub-basins: El Fuste and Harlingen. The value for the apparent diffusivity constant "b", a constant which encompasses all diffusive characteristics of the watershed or sub-basins in the watershed (i.e. the lumping constant), was calculated to be 0.85 and 0.93 for El Fuste and Harlingen, respectively, indicating that each sub-basin within the watershed is somewhat unique. Due to the lumping nature of the "b" constant, no specific factor can be attributed to this difference. More research could provide additional insight. It is suggested that water diffusion takes longer in the Harlingen sub-basin (larger "b

  2. The ascent of gravity the quest to understand the force that explains everything

    CERN Document Server

    Chown, Marcus

    2017-01-01

    Gravity is the weakest force in the everyday world yet it is the strongest force in the universe. It was the first force to be recognised and described yet it is the least understood. It is a 'force' that keeps your feet on the ground yet no such force actually exists. Gravity, to steal the words of Winston Churchill, is 'a riddle, wrapped in a mystery, inside an enigma'. And penetrating that enigma promises to answer the biggest questions in science: what is space? What is time? What is the universe? And where did it all come from? Award-winning writer Marcus Chown takes us on an unforgettable journey from the recognition of the 'force' of gravity in 1666 to the discovery of gravitational waves in 2015. And, as we stand on the brink of a seismic revolution in our worldview, he brings us up to speed on the greatest challenge ever to confront physics.

  3. Company profile: tengion.

    Science.gov (United States)

    Bertram, Timothy

    2009-05-01

    Founded in 2005, Tengion is a clinical-stage organ regeneration company with products in urologic, vascular and renal regeneration based on its proprietary Autologous Organ Regeneration Platform. Tengion uses biocompatible materials and a patient's own (autologous) cells to assemble neo-organs or neo-tissues that are designed to catalyze the body's innate ability to regenerate. Tengion is a fully-integrated organization, with scalable US and European manufacturing and distribution capabilities, experienced research, development, clinical and commercial teams, and significant intellectual property. The company's corporate headquarters and commercial manufacturing facility are in East Norriton, PA, USA, and its research offices, a development laboratory and a pilot manufacturing facility are located in Winston-Salem, NC, USA. Tengion's product candidates may ultimately address the most critical problems facing organ and tissue failure patients, enabling people to lead healthier lives without donor transplants or the side effects of related therapies.

  4. Guidelines and Data to Support Plans for Reallocating Food during Crisis Relocation. Regional Appendix. FEMA Region IV,

    Science.gov (United States)

    1982-09-01

    STORES INC JACKSON MS 2 0 0 1 1 0 8,000 LEK:IS BEAR CO INC PFI;SAUOLA FL I 1 0 0 0 0 750 LEWIS cPCCER CO INDI , NOLA IS 2 1 1 0 0 0 2,2-ro MALONE AND...SON LEWIS GROCER CO INDI;’ NOLA MS . 0 0 0 0 0 3,000 M-.LONE AND HYDE INC MO.ROE LA I 0 I 0 0 0 1,500 COUNTY TOTAL: 3 0 3 0 0 0 4,500 WINSTON GCAVES CO...SIC’PES INC RALEIGH NC I 0 0 0 1 0 5.000 SMALL SUPPLIERS I I 0 0 0 0 750 CO’NITY TOTAL: 10 I 4 3 0 30,750 PENDER QUIN; WHOLESALE CO INC WARSAW NC 0 1 0 1

  5. ES12; The 24th Annual Workshop on Recent Developments in Electronic Structure Theory

    Energy Technology Data Exchange (ETDEWEB)

    Holzwarth, Natalie [Wake Forest Univ., Winston-Salem, NC (United States); Thonhauser, Timo [Wake Forest Univ., Winston-Salem, NC (United States); Salam, Akbar [Wake Forest Univ., Winston-Salem, NC (United States)

    2012-06-29

    ES12: The 24th Annual Workshop on Recent Developments in Electronic Structure Theory was held June 5-8, 2012 at Wake Forest University in Winston-Salem, NC 27109. The program consisted of 24 oral presentations, 70 posters, and 2 panel discussions. The attendance of the Workshop was comparable to or larger than previous workshops and participation was impressively diverse. The 136 participants came from all over the world and included undergraduate students, graduate students, postdoctoral researchers, and senior scientists. The general assessment of the Workshop was extremely positive in terms of the high level of scientific presentations and discussions, and in terms of the schedule, accommodations, and affordability of the meeting.

  6. The GRAAL project

    Science.gov (United States)

    Plaga, Rainer

    The GRAAL Project (Gamma Ray Astronomy at ALmeria) makes use of the CESA-1 heliostat field at the "Plataforma Solar de Almeria" (Spain) as a gamma-ray telescope with an energy threshold of about 100 GeV. Cherenkov light generated by EAS is reflected by the heliostats and collected into photomultipliers (PMTs) with nonimaging secondary optics. Each PMT collects the light reflected by 13 - 18 heliostats of 40 m2 using a Winston cone. After successful tests with two collecting cones, a more advanced setup on a dedicated platform, using four collectors and 63 heliostats (total reflecting area of about 2500 m2 ) is being installed. A description of this setup together with Monte Carlo results about its excellent capabilities in the precise determination of pulse arrival times are presented.

  7. Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab

    Directory of Open Access Journals (Sweden)

    Greenwood GT

    2015-10-01

    Full Text Available Gregory T Greenwood Nephrology Associates, PLLC, Winston-Salem, NC, USA Abstract: Atypical hemolytic uremic syndrome (aHUS is a rare disease caused by chronic, uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy. Renal impairment and progression to end-stage renal disease are common in untreated patients with aHUS, and extrarenal manifestations are being increasingly characterized in the literature. Ocular involvement remains rare in aHUS. This report describes a patient with aHUS with bilateral central retinal artery and vein occlusion, vitreous hemorrhage, and blindness in addition to renal impairment. The patient’s hematologic and renal parameters and ocular manifestation improved following initiation of eculizumab therapy. Keywords: acute kidney injury, complement, dialysis, plasma exchange, thrombotic microangiopathy

  8. Spellbinding and crooning: sound amplification, radio, and political rhetoric in international comparative perspective, 1900-1945.

    Science.gov (United States)

    Wijfjes, Huub

    2014-01-01

    This article researches in an interdisciplinary way the relationship of sound technology and political culture at the beginning of the twentieth century. It sketches the different strategies that politicians--Franklin D. Roosevelt, Adolf Hitler, Winston Churchill, and Dutch prime minister Hendrikus Colijn--found for the challenges that sound amplification and radio created for their rhetoric and presentation. Taking their different political styles into account, the article demonstrates that the interconnected technologies of sound amplification and radio forced a transition from a spellbinding style based on atmosphere and pathos in a virtual environment to "political crooning" that created artificial intimacy in despatialized simultaneity. Roosevelt and Colijn created the best examples of this political crooning, while Churchill and Hitler encountered problems in this respect. Churchill's radio successes profited from the special circumstances during the first period of World War II. Hitler's speeches were integrated into a radio regime trying to shape, with dictatorial powers, a national socialistic community of listeners.

  9. Design Studies for a Far Infrared Absolute Spectrometer for the Cosmic Background Explorer

    Science.gov (United States)

    Johnson, N. J. E.

    1980-01-01

    Unrelenting symmetry of design is required to assure the thermal balance of a cryogenically cooled, rapid scan interferometer spectrometer to be mounted in vacuum with the Cosmic Background Explorer liquid helium dewar. The instrument receives inputs from Winston cone optical flux collectors, one open to space and a second coupled to a black body reference source. A differential instrument, the spectrometer produces outputs corresponding to the Fourier transform of the spectral radiance difference between the two inputs. The two outputs are sensed by four detectors, two optimized for shorter wavelength response, and two optimized for longer wavelengths. The optical design, detector and signal channel, system sensitivity, mechanics, thermal control and cryogenics, electronics and power systems, command and control, calibration, system test requirements, and the instrument interface are discussed. Recommendations for continued work are indicated for the superconducting reflective horns, the motor bearing and drive, and design detail.

  10. Churchill, Europe and Turkey

    Directory of Open Access Journals (Sweden)

    Warren Dockter

    2016-12-01

    Full Text Available From the early 1930s until his peace time premiership (1951-1955, Winston Churchill was one of the strongest advocates of the concept of a United Europe. While this is well known among scholars of 20th century British history, Churchill’s actual vision for what a United Europe might look like has received less attention. Still less attention has been paid to Churchill’s opinions of the roles other nations might play within the new Europe. This article will examine Churchill’s view of Turkey in the new European order and will reveal that Churchill saw Turkey as a part of, (or at least an extension of Europe. However, this article will also reveal that Churchill’s conceptualisation of Turkey’s role was largely predicated on 19th century geostrategic thinking.

  11. The Impact of the Confiscation of the Turkish Dreadnoughts and of the Transfer of Goeben and Breslau to Constantinople upon the Turkish Entry into WWI

    Directory of Open Access Journals (Sweden)

    Heinz Richter

    2013-01-01

    Full Text Available When Winston Churchill then First Sealord of the Royal Navy had the two Dreanoughts, ordered and paid for by the Ottoman Empire before World War I, confiscated he created the preconditions for the Goeben-and Breslau-affair and the entry of Turkey into the war. This “act of piracy” (B. Tuchman shifted the weight from the so far stronger neutralists to the bellicists with in the Turkish Government towards war minister Enver. Without this mistake Goeben and Breslau would never have sought shelter in Turkey. And these two men of war were the reason for Turkey’s entry into the war when they bombarded Russian harbours in the Black Sea.

  12. Combattimenti col cane nero

    Directory of Open Access Journals (Sweden)

    Mario Bruno

    2015-07-01

    Full Text Available La depressione è stata definita in svariati modi: una volta si chiamava esaurimento nervoso, oggi è “il male oscuro”, “il male di vivere”, “umor nero” o, come l’aveva soprannominata Winston Churchill, “black dog”, un “cane nero” che ci divora. Sia come sia, oggi la depressione è riconosciuta come vera e propria malattia, una patologia subdola che colpisce a tradimento. Arriva silenziosa e devastante, preceduta o meno dai micidiali attacchi di panico, e taglia le gambe, chiude la persona sofferente in un limbo di silenzio e apatia; fa vedere tutto grigio, opaco, annienta interessi, desideri e, non di rado, la voglia di vivere. Tanti sono stati vittime della depressione. Anche fra le persone più note e di successo.

  13. A historical review of R.J. Reynolds' strategies for marketing tobacco to Hispanics in the United States.

    Science.gov (United States)

    Iglesias-Rios, Lisbeth; Parascandola, Mark

    2013-05-01

    Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds' marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February-July 2011 and April-August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities.

  14. A Historical Review of R. J. Reynolds’ Strategies for Marketing Tobacco to Hispanics in the United States

    Science.gov (United States)

    Parascandola, Mark

    2013-01-01

    Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds’ marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February–July 2011 and April–August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities. PMID:23488493

  15. The nuclear threat: a new start

    Science.gov (United States)

    Drell, Sidney

    2009-02-01

    President Obama has said that he intends to "make the goal of eliminating all nuclear weapons a central element in [US] nuclear policy". He faces enormous challenges in converting this aspiration into a practical reality, both at home and abroad. One reason is that the world has become accustomed to thinking of nuclear weapons the way Winston Churchill described them in 1955: "It may be that we shall by a process of sublime irony have reached a stage in this story where safety will be the sturdy child of terror, and survival the twin brother of annihilation." Over half a century later, the world has changed and the "sublime irony" is that terror and annihilation still loom over humanity, while safety and survival are still in doubt.

  16. Towards a wider dialogue

    CERN Multimedia

    2012-01-01

    This week, I had the rewarding experience of taking part in a Wilton Park meeting examining three very different world-views: science, philosophy and theology. Wilton Park describes itself as a forum for analysing and advancing the agenda on global policy challenges, and over the years it has developed an enviable reputation for delivering authoritative reports drawn from bringing international experts together under the same roof for two days to discuss issues of topical relevance.   Participation is by invitation and there are no observers: everyone is there because they have something to bring to the discussion. Wilton Park reports always have their finger on the zeitgeist, appropriately, perhaps, for an institution born of Winston Churchill’s vision for reconciliation and dialogue in post-war Europe. When I learned that Wilton Park was running a series of meetings examining the role of religion in modern society, and that it was looking at the possibility of holding an event in...

  17. The LIFE Cognition Study: design and baseline characteristics

    Directory of Open Access Journals (Sweden)

    Sink KM

    2014-08-01

    Full Text Available Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA; 4Pennington Biomedical, Louisiana State University, Baton Rouge, LA, USA; 5Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; 6Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA; 7Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 8Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, TX, USA; 9Klein Buendel, Inc., Golden, CO, USA; 10Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 11Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Observational studies have shown beneficial relationships between exercise and cognitive function. Some clinical trials have also demonstrated improvements in cognitive function in response to moderate–high intensity aerobic exercise; however, these have been limited by relatively small sample sizes and short durations. The Lifestyle Interventions and Independence for Elders (LIFE Study is the largest and longest randomized controlled clinical trial of physical activity with cognitive outcomes, in older sedentary

  18. The Canadian cigar and tobacco journal in the forties: a remembrance.

    Science.gov (United States)

    Warsh, Cheryl Krasnick

    2006-01-01

    This paper is a period snapshot of the life and times of Canadian smoking culture, filtered through "The Canadian Cigar and Tobacco Journal" (the industry's trade paper) from 1943-1949. "The Journal" provided a vivid portrait of neighbourhood tobacconists, travelling salesman, wholesalers and factory workers, homemakers and entrepreneurs. I discuss the role of Jews in the industry, as manufacturers and retailers. "The Journal" evokes the dangers of the retail trade, such as armed robberies, as well as the dangers of wartime. There is also the parallel danger of tobacco smoking, which, although not explicitly defined as risky behaviour by physicians, nonetheless is apparent to consumers. World War II is a dominant feature of "The Journal," and the celebration of wartime tobacco consumption is epitomized by Winston Churchill and other heroic smokers. Women's increased economic participation during the war years, and postwar demobilization, is reflected in "The Journal." Finally I discuss the growing targeting of children as potential consumers of tobacco.

  19. STS-87 Mission Specialist Scott poses in his launch and entry spacesuit at LC 39B during TCDT

    Science.gov (United States)

    1997-01-01

    STS-87 Mission Specialist Winston Scott poses in his orange launch and entry spacesuit with NASA suit technicians at Launch Pad 39B during Terminal Countdown Demonstration Test (TCDT) activities. The crew of the STS-87 mission is scheduled for launch Nov. 19 aboard the Space Shuttle Columbia. Scott will be performing an extravehicular activity (EVA) spacewalk during the mission. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

  20. Twenty Years of KSHV

    Directory of Open Access Journals (Sweden)

    Yuan Chang

    2014-11-01

    Full Text Available Twenty years ago, Kaposi’s sarcoma (KS was the oncologic counterpart to Winston Churchill’s Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men—in fact, most KS patients were expected to die with the tumor rather than from it. Nevertheless, the course and manifestations of the disease varied widely in different clinical contexts. The puzzle of KS came to the forefront as a harbinger of the AIDS epidemic. The articles in this issue of Viruses recount progress made in understanding Kaposi’s sarcoma herpesvirus (KSHV since its initial description in 1994.

  1. Europe from challenges of war towards challenges of peace

    Directory of Open Access Journals (Sweden)

    Fahredin Shabani

    2017-11-01

    Full Text Available The end of the WWII, did not bring peace and harmony among the peoples of Europe and World as expected. Enmity of the war time created such a deep ditch, which could not be overcome for a short time. What’s more, even among the allies-winners of the war, friendship and cooperation did not last too long. Very soon, two-three years after the end of the war, Europe was separated by an iron curtain, as Winston Churchill, the British prime minister would call it. The shadow of this division, first of all ideological, became known mostly in South Eastern European countries. This region, for about half of a century was seized by stalinism and democracy. Consequences of this division were not only political. Division produced economic and development consequences, which, in one or many ways, even nowadays, hinder this region in the European and Euro-Atlantic integration processes.

  2. The future of meat: a qualitative analysis of cultured meat media coverage.

    Science.gov (United States)

    Goodwin, J N; Shoulders, C W

    2013-11-01

    This study sought to explore the informational themes and information sources cited by the media to cover stories of cultured meat in both the United States and the European Union. The results indicated that cultured meat news articles in both the United States and the European Union commonly discuss cultured meat in terms of benefits, history, process, time, livestock production problems, and skepticism. Additionally, the information sources commonly cited in the articles included cultured meat researchers, sources from academia, People for the Ethical Treatment of Animals (PETA), New Harvest, Winston Churchill, restaurant owners/chefs, and sources from the opposing countries (e.g. US use some EU sources and vice versa). The implications of this study will allow meat scientists to understand how the media is influencing consumers' perceptions about the topic, and also allow them to strategize how to shape future communication about cultured meat. Published by Elsevier Ltd.

  3. Resistance exercise performance variability at submaximal intensities in older and younger adults

    Directory of Open Access Journals (Sweden)

    Grosicki GJ

    2014-01-01

    Full Text Available Gregory J Grosicki,1 Michael E Miller,2 Anthony P Marsh1 1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA; 2Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: We assessed the variability in the number of repetitions completed at submaximal loads in three resistance tasks in older (N=32, 16 female, 74.3±5.4 years and younger (N=16, 8 female, 22.8±1.8 years men and women. One repetition maximum (1RM was determined on two separate visits on three tasks: leg press (LP, leg extension (LE, and bicep curl (BC. Subjects then completed repetitions to failure on each of the three tasks during two visits, a minimum of 48 hours apart, at either 60% 1RM or 80% 1RM. High reliability for all 1RM assessments was observed. Greater muscular strength was observed in younger compared to older men and women on all tasks (P<0.05. At both 60% and 80% 1RM, considerable interindividual variability was observed in the number of repetitions completed. However, the average number of repetitions completed by younger and older men and women at 60% and 80% 1RM in each of the three tasks was similar, with the only significant difference occurring between younger and older men at 80% 1RM on the leg press (P=0.0258. We did not observe any abnormal blood pressure responses to either the 1RM testing or maximal repetition testing sessions. Considerable interindividual variability was observed in the number of repetitions completed by younger and older men and women at relative intensities typical of resistance training programs. Practitioners should give consideration to individual variability when attempting to maximize the benefits of resistance training. Keywords: resistance exercise, exercise prescription, relative intensity, reliability, older adults, blood pressure

  4. Interventions to increase adherence to acne treatment

    Directory of Open Access Journals (Sweden)

    Moradi Tuchayi S

    2016-10-01

    Full Text Available Sara Moradi Tuchayi,1 Tiffany M Alexander,2 Anish Nadkarni,1 Steven R Feldman1,3,4 1Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, 2Howard University College of Medicine, Washington, DC, 3Department of Public Health Sciences, 4Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA Background: Adherence to acne medication is poor and is a major reason why treatment plans are ineffective. Recognizing solutions to nonadherence is critical. Objective: The purpose of this study is to describe the hurdles associated with acne nonadherence and to provide mechanisms on how to ameliorate them. Methods: PubMed database was searched. Of the 419 search results, 29 articles were reviewed to identify hurdles to adherence and corresponding solutions. Results: Hurdles to primary nonadherence where the medication is not even started, include lack of knowledge, confusion about usage, weak physician–patient relationship, fear of adverse reactions, and cost. Secondary nonadherence hurdles where the medication is started but is not taken as directed include lack of results, complex regimens, side effects, busy lifestyle, forgetfulness, inconvenience, and psychiatric comorbidity. Solutions to these hurdles include treatment simplification, technology, and dynamic education. Limitations: Adherence is affected by numerous factors, but available literature analyzing acne adherence and interventions to improve adherence to treatment is limited. Conclusion: There are several hurdles in adhering to acne treatment. Recognition of these hurdles and finding appropriate solutions may be as important to treatment outcomes as choosing the right medication to prescribe. Keywords: acne vulgaris, adherence, pathogenesis, treatment, quality of life, prevalence, physician–patient relationship, lifestyle, clinic visit, disease severity

  5. SU-F-J-37: Commissioning a Six Degree of Freedom Couch

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, D; Lam, K; Bredfeldt, J; Covington, E [University of Michigan Hospital and Health Systems, Ann Arbor, MI (United States)

    2016-06-15

    Purpose: The proper operation of a six degree of freedom couch (6DOFC) to position a patient for treatment requires that a number systems on the treatment unit work together correctly. Commissioning a 6DOFC requires not only the commissioning of each separate system but also commissioning the interactions between the systems. Methods: To commission a 6DOFC, we tested the resolvers that readout the linear and angular positions; the orthogonality of the axes of the laser positioning system, the imaging system, the gantry and the couch as well as their relationship to each other. An automated Winston-Lutz test was used verify the coincidence of the origins of the laser system, imaging system and treatment unit. The IsoCal phantom was used to verify the consistency of axes orientations between systems. The operation of the couch and imaging system was verified under simulated load conditions and an end to end test was performed to verify correct operation of the system. Results: The tests on the couch resolvers, orthogonality and coincidence of the axes of each system were successfully completed and showed excellent agreement. The automated Winston-Lutz test showed that the maximum displacement of the center of the radiation field with respect to the isocenter was <0.6 mm (radius) at isocenter. The analysis of the IsoCal phantom showed that the maximum variation of the radiation field with respect to known locations in the phantom was ∼0.9 mm for all the BBs in the phantom. Load tests showed maximum errors of 1 mm. Conclusion: We tested all system associated with the 6DOFC and found the uncertainty due to imaging was <.9mm and the uncertainty due to loading ∼1 mm, resulting in a total error of ∼1.4 mm.

  6. Lennox–Gastaut syndrome: impact on the caregivers and families of patients

    Directory of Open Access Journals (Sweden)

    Gibson PA

    2014-10-01

    Full Text Available Patricia A Gibson Epilepsy Information Service, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Lennox–Gastaut syndrome (LGS has a major impact on the health-related quality of life (HRQL of the affected children as well as their caregivers. The primary caregiver in the family is generally the mother, with support from the father and siblings. The burden of care and the effects of the disease on the child necessitate adjustments in virtually all aspects of the lives of their family. These adjustments inevitably affect the physical, emotional, social, and financial health of the whole family. Numerous sources of support for families can help to ease the burden of care. Improvements in the treatment of LGS, in addition to helping the child with LGS, would likely help improve the HRQL of the family members. This pilot parent survey was designed to explore the impact of epilepsy on caregiver HRQL. Parents of children with epilepsy who had contacted the Epilepsy Information Service at the Wake Forest University School of Medicine, Winston-Salem, NC, USA, were sent questionnaires comprising open- and closed-ended questions. A total of 200 surveys were distributed, with a return rate of 48%. The results revealed that 74% of the parents believed that having a child with epilepsy brought them and their partner closer together. However, when the parents were asked to explain the manner in which epilepsy affected their families, answers included continuous stress, major financial distress, and lack of time to spend with other children. Information and resources for the families of children with LGS could help improve the HRQL of both the patients and their relatives. Keywords: health-related quality of life, HRQL, epilepsy, relatives, siblings

  7. Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan

    Directory of Open Access Journals (Sweden)

    Varagic J

    2014-11-01

    Full Text Available Jasmina Varagic,1–3 Henry Punzi,4,5 Carlos M Ferrario2,3,61Hypertension and Vascular Research Center, 2Division of Surgical Sciences, 3Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC USA; 4Trinity Hypertension and Diagnostic Research Center, Carrollton, TX, USA; 5Department of Family and Community Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; 6Department of Internal Medicine and Nephrology, Wake Forest University, Winston-Salem, NC, USAAbstract: Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titrated single agents, and to increase persistence and adherence with antihypertensive therapy. Multiple clinical trials provide evidence that fixed-dose combinations in a single pill offer several advantages when compared with loose-dose combinations. This review discusses the advances in hypertension control and associated cardiovascular disease as they relate to the prospect of combination therapy targeting a third-generation beta (β 1-adrenergic receptor (nebivolol and an angiotensin II receptor blocker (valsartan in fixed-dose single-pill formulations.Keywords: blood pressure control, hypertension, β1-adrenergic receptor, renin angiotensin system

  8. Land Use Adaptation to Climate Change: Economic Damages from Land-Falling Hurricanes in the Atlantic and Gulf States of the USA, 1900–2005

    Directory of Open Access Journals (Sweden)

    Asim Zia

    2012-05-01

    Full Text Available Global climate change, especially the phenomena of global warming, is expected to increase the intensity of land-falling hurricanes. Societal adaptation is needed to reduce vulnerability from increasingly intense hurricanes. This study quantifies the adaptation effects of potentially policy driven caps on housing densities and agricultural cover in coastal (and adjacent inland areas vulnerable to hurricane damages in the Atlantic and Gulf Coastal regions of the U.S. Time series regressions, especially Prais-Winston and Autoregressive Moving Average (ARMA models, are estimated to forecast the economic impacts of hurricanes of varying intensity, given that various patterns of land use emerge in the Atlantic and Gulf coastal states of the U.S. The Prais-Winston and ARMA models use observed time series data from 1900 to 2005 for inflation adjusted hurricane damages and socio-economic and land-use data in the coastal or inland regions where hurricanes caused those damages. The results from this study provide evidence that increases in housing density and agricultural cover cause significant rise in the de-trended inflation-adjusted damages. Further, higher intensity and frequency of land-falling hurricanes also significantly increase the economic damages. The evidence from this study implies that a medium to long term land use adaptation in the form of capping housing density and agricultural cover in the coastal (and adjacent inland states can significantly reduce economic damages from intense hurricanes. Future studies must compare the benefits of such land use adaptation policies against the costs of development controls implied in housing density caps and agricultural land cover reductions.

  9. Victory Gin Lane. Starvation and Beverages in Orwell’s Nineteen Eighty-Four

    Directory of Open Access Journals (Sweden)

    Paolo Caponi

    2015-05-01

    Full Text Available Gin is an ubiquitous presence in the domestic and urban scenery of Nineteen Eighty-Four (1949. For a population mercilessly hungered, it represents a handy and cheap commodity item providing a fluid opportunity for social aggregation. Victory Gin, served “in handless chine mugs” (53, is part of the workers’ staple diet at the Ministry of Truth, and is sold “at ten cents the large nip” from the small bar (actually, “a mere hole in the wall”, 51 in the canteen; served with cloves, it is the “speciality” (79 of that disreputable place which is the Chestnut Tree Café, where Winston Smith once spotted three fallen-out-of-favor members of the Inner Party – Jones, Aaronson and Rutherford – drink it silently after their release from Oceania prison camps (79. As is typical of the fate of spirits in literature, gin also serves as self-medication and can fuel a kind of inner escapism. It is to make the world “look more cheerful” that Winston gulps it down “like a dose of medicine”, and only after the “shock” of swallowing it can he squeeze himself into his alcove and begin his diary (7; gin clears out Winston’s stomach (53, and is the ultima ratio against that prescient “dull ache” in his belly (105; 106 that originates after bumping into “the girl with dark hair” (later: Julia one evening outside Mr. Charrington’s shop.

  10. Association of Geography and Ambient Air Pollution with Urine Metal Concentrations in Six US Cities: The Multi-Ethnic Study of Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Yuanjie Pang

    2016-03-01

    Full Text Available We investigated the associations of urinary concentrations of antimony, cadmium, tungsten and uranium with geographic locations and with ambient air pollution in 304 adults in the Multi-Ethnic Study of Atherosclerosis from six US cities. After adjustment for sociodemographics, body mass index, and smoking status, urinary cadmium was the highest in Winston-Salem among all study sites (the geometric mean [GM] in Winston-Salem was 0.84 µg/L [95% confidence interval (CI 0.57–1.22]. The adjusted GMs of urinary tungsten and uranium were highest in Los Angeles (0.11 µg/L [95% CI 0.08–0.16] and 0.019 µg/L [95% CI 0.016–0.023], respectively. The adjusted GM ratio comparing fine particulate matter (PM2.5 tertiles 2 and 3 with the lowest tertile were 1.64 (95% CI 1.05–2.56 and 3.55 (95% CI 2.24–5.63 for tungsten, and 1.18 (95% CI 0.94–1.48 and 1.70 (95% CI 1.34–2.14 for uranium. The results for tungsten remained similar after adjustment for study site. Urinary cadmium, tungsten and uranium concentrations differed by geographic locations in MESA (Multi-Ethnic Study of Atherosclerosis communities. PM2.5 levels could contribute to geographic differences in tungsten exposure. These findings highlight the need to implement preventive strategies to decrease toxic metal exposure and to evaluate the health effects of chronic exposure to those metals.

  11. Tuning the C-H···π Interaction by Different Substitutions in Benzene-Acetylene Complexes.

    Science.gov (United States)

    Mishra, Brijesh Kumar; Karthikeyan, S; Ramanathan, V

    2012-06-12

    The influence of substitutions in aromatic moieties on the binding strength of their complexes is a subject of broad importance. Using a set of various substituted benzenes, Sherrill and co-workers ( J. Am. Chem. Soc. 2011 , 133 , 13244 ; J. Phys. Chem. A 2003 , 107 , 8377 ) recently showed that the strength of a stacking interaction (π···π interaction) is enhanced by adding substituents regardless of their nature. Although the binding strength of an activated C-H···π interaction is comparable to that of a stacking interaction, a similar systematic study is hitherto unknown in the literature. We have computed the stabilization energies of the C-H···π complex of acetylene and multiple fluoro-/methyl-substituted benzenes at the coupled-cluster single and double (triple) excitation [CCSD(T)]/complete basis set (CBS) limit. The trend for interaction energies was found to be hexafluorobenzene-acetylene J. Am. Chem. Soc. 2011 , 133 , 13244 ), we show here that electron-withdrawing groups weaken the dimer while electron-donating groups strengthen the interaction energy of the dimer. Various recently developed density functional theoretic (DFT) methods were assessed for their performance and the M05-2X, M06-2X, and ωB97X-D methods were found to be the best performers. These best DFT performers were employed in determining the influence of other representative substituents (-NO2, -CN, -COOH, -Br, -Cl, -OH, and -NH2) as an extension to the above work. The results for the complex of acetylene and various para-disubstituted benzenes revealed a trend in binding energies that is in accordance with the ring-activating/deactivating capacity of each of these groups. The stabilization energy was partitioned via the DFT symmetry-adapted perturbation theory (SAPT) method, and both dispersion and electrostatic interactions were seen to be major driving forces for the complex stabilization. Interestingly, the sum of the energy contributors such as dispersion, exchange

  12. Teacher leadership in mathematics and science: Subject content knowledge and the improvement of instruction

    Science.gov (United States)

    Manno, Christopher M.

    This study explores the role of teacher leader subject content knowledge in the promotion of professional development and instructional reform. Consistent with a distributed leadership perspective, many have asserted that the promotion of school effectiveness can be enhanced through the application of teacher leadership (Frost & Durrant, 2003; Harris, 2002a; Sherrill, 1999; Silva, Gimbert, & Nolan, 2000; York-Barr & Duke, 2004). There has been much discussion in the research about the significance of teachers' subject content knowledge in teaching and learning which has generally asserted a positive relationship with instructional practice and student achievement (Darling-Hammond, 2000; Newton & Newton, 2001; Parker & Heywood, 2000). The role of content knowledge in teacher leader work has been less researched. This study focused on deepening understanding of perceptions regarding teacher leaders' roles in improving instructional practice. Based on a framework of common teacher leader tasks, qualitative methods were used to investigate the relationship between teacher leader subject content knowledge and perceptions of effectiveness in promoting professional development and instructional reform. The study indicates that content experts behave differently than their non-expert counterparts. Content experts recognize deficiencies in colleagues' content knowledge as a primary problem in the implementation of math or science reform. Content experts view their work as advocacy for improved curriculum and instruction for all children, and work within a small set of task categories to promote discussions about teaching, learning, and content. Content experts develop trust and rapport with colleagues by demonstrating expertise, and are respected for their deep knowledge and efforts to help teachers learn the content. They also differ from non-content experts in the professional growth experiences in which they engage. The consideration of content expertise as an influence

  13. Studying the clinical encounter with the Adaptive Leadership framework

    Directory of Open Access Journals (Sweden)

    Bailey Jr DE

    2012-08-01

    Full Text Available Donald E Bailey Jr,1,2 Sharron L Docherty,1 Judith A Adams,1 Dana L Carthron,3 Kirsten Corazzini,1,2 Jennifer R Day,1 Elizabeth Neglia,1 Marcus Thygeson,4 Ruth A Anderson1,21School of Nursing, Duke University, 2Center for the Study of Aging and Human Development, Duke University, Durham, NC, 3School of Health Science, Division of Nursing, Winston Salem State University, Winston Salem, NC, 4Medical Services, Blue Shield of California, San Francisco, CA, USAAbstract: In this paper we discuss the concept of leadership as a personal capability, not contingent on one's position in a hierarchy. This type of leadership allows us to reframe both the care-giving and organizational roles of nurses and other front-line clinical staff. Little research has been done to explore what leadership means at the point of care, particularly in reference to the relationship between health care practitioners and patients and their family caregivers. The Adaptive Leadership framework, based on complexity science theory, provides a useful lens to explore practitioners' leadership behaviors at the point of care. This framework proposes that there are two broad categories of challenges that patients face: technical and adaptive. Whereas technical challenges are addressed with technical solutions that are delivered by practitioners, adaptive challenges require the patient (or family member to adjust to a new situation and to do the work of adapting, learning, and behavior change. Adaptive leadership is the work that practitioners do to mobilize and support patients to do the adaptive work. The purpose of this paper is to describe this framework and demonstrate its application to nursing research. We demonstrate the framework's utility with five exemplars of nursing research problems that range from the individual to the system levels. The framework has the potential to guide researchers to ask new questions and to gain new insights into how practitioners interact with

  14. WE-G-BRA-02: SafetyNet: Automating Radiotherapy QA with An Event Driven Framework

    International Nuclear Information System (INIS)

    Hadley, S; Kessler, M; Litzenberg, D; Lee, C; Irrer, J; Chen, X; Acosta, E; Weyburne, G; Lam, K; Younge, K; Matuszak, M; Keranen, W; Covington, E; Moran, J

    2015-01-01

    Purpose: Quality assurance is an essential task in radiotherapy that often requires many manual tasks. We investigate the use of an event driven framework in conjunction with software agents to automate QA and eliminate wait times. Methods: An in house developed subscription-publication service, EventNet, was added to the Aria OIS to be a message broker for critical events occurring in the OIS and software agents. Software agents operate without user intervention and perform critical QA steps. The results of the QA are documented and the resulting event is generated and passed back to EventNet. Users can subscribe to those events and receive messages based on custom filters designed to send passing or failing results to physicists or dosimetrists. Agents were developed to expedite the following QA tasks: Plan Revision, Plan 2nd Check, SRS Winston-Lutz isocenter, Treatment History Audit, Treatment Machine Configuration. Results: Plan approval in the Aria OIS was used as the event trigger for plan revision QA and Plan 2nd check agents. The agents pulled the plan data, executed the prescribed QA, stored the results and updated EventNet for publication. The Winston Lutz agent reduced QA time from 20 minutes to 4 minutes and provided a more accurate quantitative estimate of radiation isocenter. The Treatment Machine Configuration agent automatically reports any changes to the Treatment machine or HDR unit configuration. The agents are reliable, act immediately, and execute each task identically every time. Conclusion: An event driven framework has inverted the data chase in our radiotherapy QA process. Rather than have dosimetrists and physicists push data to QA software and pull results back into the OIS, the software agents perform these steps immediately upon receiving the sentinel events from EventNet. Mr Keranen is an employee of Varian Medical Systems. Dr. Moran’s institution receives research support for her effort for a linear accelerator QA project from

  15. Enhancing mHealth Technology in the Patient-Centered Medical Home Environment to Activate Patients With Type 2 Diabetes: A Multisite Feasibility Study Protocol.

    Science.gov (United States)

    Gimbel, Ronald; Shi, Lu; Williams, Joel E; Dye, Cheryl J; Chen, Liwei; Crawford, Paul; Shry, Eric A; Griffin, Sarah F; Jones, Karyn O; Sherrill, Windsor W; Truong, Khoa; Little, Jeanette R; Edwards, Karen W; Hing, Marie; Moss, Jennie B

    2017-03-06

    Diabetes Self-care Activities Measure scores, clinical measures, comorbid conditions, health services resource consumption, and technology system usage statistics. We have completed phase 1 data collection. Formal analysis of phase 1 data has not been completed. We have obtained institutional review board approval and began phase 1 research in late fall 2016. The study hypotheses suggest that patients can, and will, improve their activation in chronic care management. Improved activation should translate into improved diabetes self-care. Expected benefits of this research to the scientific community and health care services include improved understanding of how to leverage mHealth technology to activate patients living with type 2 diabetes in self-management behaviors. The research will shed light on implementation strategies in integrating mHealth into the clinical workflow of the PCMH setting. ClinicalTrials.gov NCT02949037. https://clinicaltrials.gov/ct2/show/NCT02949037. (Archived by WebCite at http://www.webcitation.org/6oRyDzqei). ©Ronald Gimbel, Lu Shi, Joel E Williams, Cheryl J Dye, Liwei Chen, Paul Crawford, Eric A Shry, Sarah F Griffin, Karyn O Jones, Windsor W Sherrill, Khoa Truong, Jeanette R Little, Karen W Edwards, Marie Hing, Jennie B Moss. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 06.03.2017.

  16. "And they told two friends...and so on": RJ Reynolds' viral marketing of Eclipse and its potential to mislead the public.

    Science.gov (United States)

    Anderson, S J; Ling, P M

    2008-08-01

    To explore viral marketing strategies for Eclipse cigarettes used by the RJ Reynolds Company (Winston-Salem, North Carolina, USA). Analysis of previously secret tobacco industry documents and multimedia materials. The failure of RJ Reynolds' (RJR) 1988 "smokeless" cigarette, Premier, was in part due to widespread bad word of mouth about the product's flavour, quality and difficulty of use. In 1994 RJR introduced an updated version of Premier, the ostensibly "reduced risk" Eclipse cigarette. RJR developed viral marketing channels to promote Eclipse using (1) exploratory interviews to motivate consumers to spread the word about Eclipse prior to market release, (2) promotional videos featuring positive feedback from test group participants to portray majority consensus among triers, (3) "Tupperware"-like parties for Eclipse where participants received samples to pass around in their social circles and (4) the Eclipse website's bulletin board as a forum for potential users to discuss the brand in their own words. These strategies targeted the brand's likeliest adopters, recruited informal and credible representatives of the product unaffiliated with RJR, and controlled the information spread about the product. Viral marketing techniques may be particularly useful to promote new tobacco products such as Eclipse that have limited appeal and need a highly motivated audience of early adopters and acceptors. Such techniques help evade the mass rejection that could follow mass promotion, circumvent marketing restrictions, and allow tobacco companies to benefit from health claims made by consumers. Cigarette manufacturers must be held accountable for perceived health benefits encouraged by all promotional activities including viral marketing.

  17. Is Democracy Possible Without a Restriction of the Suffrage?

    Directory of Open Access Journals (Sweden)

    Alfano Vincenzo

    2014-09-01

    Full Text Available Today, the concept of democracy seems inextricably linked with that of universal suffrage. But is it true? To let that anyone with a given age has the right to vote is a very good democratic practice, or would prefer to question the criteria for access to this right, perhaps to develop new systems? The current crisis of democracy in the Western world is symptomatic of a detriment of the political consciousness of the people? And yet it is very likely to be admissible and that only from the mass, the large numbers, rises the better choices? In this paper I try to answer these questions, drawing from personal opinions and thoughts, which I hope will inspire questions and curiosity in those who, like me, believes that any system is always perfectible, and that its aim should be to that perfection, without fear of asking uncomfortable questions. Personally, in fact, I can accept democracy as “the worst form of government except all the others that have been tried”, to quote a famous statement by Winston Churchill. But not for that I give up, and I try other ways. Ways that are more satisfying, more fair and keep us away from the horrors that only an angry mob can do.

  18. Cardiovascular risk prediction: the old has given way to the new but at what risk-benefit ratio?

    Directory of Open Access Journals (Sweden)

    Yeboah J

    2014-10-01

    Full Text Available Joseph Yeboah Heart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: The ultimate goal of cardiovascular risk prediction is to identify individuals in the population to whom the application or administration of current proven lifestyle modifications and medicinal therapies will result in reduction in cardiovascular disease events and minimal adverse effects (net benefit to society. The use of cardiovascular risk prediction tools dates back to 1976 when the Framingham coronary heart disease risk score was published. Since then a lot of novel risk markers have been identified and other cardiovascular risk prediction tools have been developed to either improve or replace the Framingham Risk Score (FRS. In 2013, the new atherosclerotic cardiovascular disease risk estimator was published by the American College of Cardiology and the American Heart Association to replace the FRS for cardiovascular risk prediction. It is too soon to know the performance of the new atherosclerotic cardiovascular disease risk estimator. The risk-benefit ratio for preventive therapy (lifestyle modifications, statin +/− aspirin based on cardiovascular disease risk assessed using the FRS is unknown but it was assumed to be a net benefit. Should we also assume the risk-benefit ratio for the new atherosclerotic cardiovascular disease risk estimator is also a net benefit? Keywords: risk prediction, prevention, cardiovascular disease

  19. On meronymy

    Directory of Open Access Journals (Sweden)

    Dilparić Branislava M.

    2012-01-01

    Full Text Available In spite of the fact that there is a long tradition of its research, which dates from the period of ancient philosophy and which, since the 20th century, has been conducted from the perspective of several disciplines (logic/philosophy, psychology, linguistics, visual perception, artificial intelligence etc., the relation between parts and wholes (the so-called meronymy, partonymy, or part-whole relation still causes a lot of confusion and controversy. There is even no consensus on the interpretation of the fundamental terms ‘part’ and ‘whole’, as well as on the status and definition of their relation. While meronymy is often mentioned, along with synonymy, antonymy, and hyponymy, in lists of semantic relations among words, lexicology has traditionally paid it less attention than the other relations, as this relation is mostly regarded as a part of encyclopedic (rather than definitional knowledge. Recent changes in approaches to meaning, however, have resulted in more attention to meronymy, and the relation is now relevant for several applied linguistic endeavors. For instance, the PART-OF relation, like the TYPE-OF relation (hyponymy is central to the creation of dictionary definitions. Since meronymy has not yet been often considered in the linguistic literature in Serbian, this paper presents a part of theoretical considerations on this relation, mostly based on Cruse (1995; 2004a; 2004b, Croft and Cruse (2004, and Winston et al. (1987.

  20. APPLICATION OF IMAGE ANALYSIS METHODS FOR ISOCENTER QUALITY ASSURANCE IN RADIOTHERAPY

    Directory of Open Access Journals (Sweden)

    Michał Niedźwiecki

    2017-03-01

    Full Text Available One of the major procedures for testing the geometrical accuracy of devices used in radiotherapy treatments is the test of the geometrical position of the radiation isocenter. The importance of the test reflects the fact that geometrical position of the radiation isocenter generally affects the tumor targeting. At present the geometric accuracy is assessed with the Winston-Lutz test which checks the position of an image of a ball marker with the respect to the center of the radiation field as projected on a detector plane. Obviously, determination of coordinates of a single marker is not sufficient to fully account for a complicated geometry of a therapeutic device. The purpose of the study was to design a new image analysis tool to better determine the isocenter. The proposed automated procedure for determining isocenter position uses projection data acquired for a special cube phantom. The projection images of a phantom are acquired for various angles of rotation of the gantry. A procedure is proposed to extract some geometric characteristics of a therapeutic device from the projection images.

  1. Hydrogen and oxygen isotope constraints on hydrothermal alteration of the Trinity peridotite, Klamath Mountains, California

    Science.gov (United States)

    Liakhovitch, V.; Quick, J.E.; Gregory, R.T.

    2005-01-01

    The Trinity peridotite represents a rare opportunity to examine a relatively fertile plagioclase peridotite that was exhumed and later subjected to intrusive events in a seafloor environment, followed by its emplacement and incorporation into a continent. Over 250 stable isotopic determinations on whole rocks and minerals elucidate the hydrothermal evolution of the Trinity complex. All three serpentine polymorphs are present in the Trinity peridotite; these separate on the basis of their ??D values: antigorite, -46 peridotite, gabbro, and late Mesozoic granodiorite indicate a progressive 18O enrichment with time for the source regions of the rocks. These isotopic signatures are consistent with the geology, petrochemistry, and geochronology of the Trinity massif, which indicate the following history: (1) lithospheric emplacement and cooling of the peridotite in an oceanic environment ??? 472 Ma; (2) intrusion of gabbroic plutons into cold peridotite in an arc environment between 435 and 404 Ma; and finally (3) intrusion of felsic plutons between 171 and 127 Ma, long after the peridotite was incorporated into the continental crust. Copyright ?? 2005 by V. H. Winston & Son, Inc. All rights reserved.

  2. Automatic analysis of image quality control for Image Guided Radiation Therapy (IGRT) devices in external radiotherapy

    International Nuclear Information System (INIS)

    Torfeh, Tarraf

    2009-01-01

    On-board imagers mounted on a radiotherapy treatment machine are very effective devices that improve the geometric accuracy of radiation delivery. However, a precise and regular quality control program is required in order to achieve this objective. Our purpose consisted of developing software tools dedicated to an automatic image quality control of IGRT devices used in external radiotherapy: 2D-MV mode for measuring patient position during the treatment using high energy images, 2D-kV mode (low energy images) and 3D Cone Beam Computed Tomography (CBCT) MV or kV mode, used for patient positioning before treatment. Automated analysis of the Winston and Lutz test was also proposed. This test is used for the evaluation of the mechanical aspects of treatment machines on which additional constraints are carried out due to the on-board imagers additional weights. Finally, a technique of generating digital phantoms in order to assess the performance of the proposed software tools is described. Software tools dedicated to an automatic quality control of IGRT devices allow reducing by a factor of 100 the time spent by the medical physics team to analyze the results of controls while improving their accuracy by using objective and reproducible analysis and offering traceability through generating automatic monitoring reports and statistical studies. (author) [fr

  3. Proposed stratotype for the base of the highest Cambrian stage at the first appearance datum of Cordylodus andresi, Lawson Cove section, Utah, USA

    Science.gov (United States)

    Miller, J.F.; Ethington, Raymond L.; Evans, K.R.; Holmer, L.E.; Loch, James D.; Popov, L.E.; Repetski, J.E.; Ripperdan, R.L.; Taylor, John F.

    2006-01-01

    We propose a candidate for the Global Standard Stratotype-section and Point (GSSP) for the base of the highest stage of the Furongian Series of the Cambrian System. The section is at Lawson Cove in the Ibex area of Millard County, Utah, USA. The marker horizon is the first appearance datum (FAD) of the conodont Cordylodus andresi Viira et Sergeyeva in Kaljo et al. [Kaljo, D., Borovko, N., Heinsalu, H., Khazanovich, K., Mens, K., Popov, L., Sergeyeva, S., Sobolevskaya, R., Viira, V., 1986. The Cambrian-Ordovician boundary in the Baltic-Ladoga clint area (North Estonia and Leningrad Region, USSR). Eesti NSV Teaduste Akadeemia Toimetised. Geologia 35, 97-108]. At this section and elsewhere this horizon also is the FAD of the trilobite Eurekia apopsis (Winston et Nicholls, 1967). This conodont characterizes the base of the Cordylodus proavus Zone, which has been recognized in many parts of the world. This trilobite characterizes the base of the Eurekia apopsis Zone, which has been recognized in many parts of North America. The proposed boundary is 46.7 m above the base of the Lava Dam Member of the Notch Peak Formation at the Lawson Cove section. Brachiopods, sequence stratigraphy, and carbon-isotope geochemistry are other tools that characterize this horizon and allow it to be recognized in other areas. ?? 2006 Nanjing Institute of Geology and Palaeontology, CAS.

  4. Hard disks with SCSI interface

    CERN Document Server

    Denisov, O Yu

    1999-01-01

    The testing of 20 models of hard SCSI-disks is carried out: the Fujitsu MAE3091LP; the IBM DDRS-39130, DGHS-318220, DNES-318350, DRHS-36V and DRVS-18V; the Quantum Atlas VI 18.2; the Viking 11 9.1; the Seagate ST118202LW, ST118273LW, ST118273W, ST318203LW, ST318275LW, ST34520W, ST39140LW and ST39173W; and the Western Digital WDE9100-0007, WDE9100-AV0016, WDE9100-AV0030 and WDE9180-0048. All tests ran under the Windows NT 4.0 workstation operating system with Service Pack 4, under video mode with 1024*768 pixel resolution, 32- bit colour depth and V-frequency equal to 85 Hz. The detailed description and characteristics of SCSI stores are presented. Test results (ZD Winstone 99 and ZD WinBench 99 tests) are given in both table and diagram (disk transfer rate) forms. (0 refs).

  5. Using MapMyFitness to Place Physical Activity into Neighborhood Context

    Directory of Open Access Journals (Sweden)

    Jana Ariel Hirsch

    2014-03-01

    Full Text Available It is difficult to obtain detailed information on the context of physical activity at large geographic scales, such as the entire United States, as well as over long periods of time, such as over years. MapMyFitness is a suite of interactive tools for individuals to track their workouts online or using GPS in their phones or other wireless trackers. This method article discusses the use of physical activity data tracked using MapMyFitness to examine patterns over space and time. An overview of MapMyFitness, including data tracked, user information, and geographic scope, is explored. We illustrate the utility of MapMyFitness data using tracked physical activity by users in Winston-Salem, NC between 2006 and 2013. Types of physical activities tracked are described, as well as the percent of activities occurring in parks. Strengths of MapMyFitness data include objective data collection, low participant burden, extensive geographic scale, and longitudinal series. Limitations include generalizability, behavioral change as the result of technology use, and potential ethical considerations. MapMyFitness is a powerful tool to investigate patterns of physical activity across large geographic and temporal scales.

  6. Self-Expandable Metal Stent Placement for Closure of a Leak after Total Gastrectomy for Gastric Cancer: Report on Three Cases and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Dario Raimondo

    2014-01-01

    Full Text Available In the setting of the curative oncological surgery, the gastric surgery is exposed to complicated upper gastrointestinal leaks, and consequently the management of this problem has become more critically focused than was previously possible. We report here three cases of placement of a partially silicone-coated SEMS (Evolution Controlled Release Esophageal Stent System, Cook Medical, Winston-Salem, NC, USA in patients who underwent total gastrectomy with Roux-en-Y end-to-side esophagojejunostomy for a gastric adenocarcinoma. The promising results of our report, despite the small number of patients, suggest that early stenting (through a partially silicone-coated SEMS is a feasible alternative to surgical treatment in this subset of patients. In fact, in the treatment of leakage after total gastrectomy, plastic stents and totally covered metallic stents may not adhere sufficiently to the esophagojejunal walls and, as a result, migrate beyond the anastomosis. However, prospective studies with a larger number of patients might assess the real effectiveness and safety of this procedure.

  7. Relying on the National Mobile Disaster Hospital as a business continuity strategy in the aftermath of a tornado: The Louisville experience.

    Science.gov (United States)

    Kearns, Randy D; Stringer, Lew; Craig, James; Godette-Crawford, Regina; Black, Paul S; Andra, David L; Winslow, James

    2017-01-01

    On 28th April, 2014, a tornado left much of Louisville, MS and the local hospital, Winston Medical Center, in ruin. In the USA, temporary hospital solutions have been used to augment the mainstream healthcare system since the American Civil War. As memories fade, however, the necessary readiness for a temporary hospital also fades, at times leaving a patchwork of resources either underfunded or abandoned. With the creation of the Hospital Preparedness Program, several temporary hospital solutions were created in various states across the USA. In the present case, Mississippi and North Carolina resources were used in Louisville in the aftermath of a direct impact that destroyed the hospital and nursing home. In the hours that followed, after lives were saved and patients safely relocated, a frank assessment confirmed the structural loss of the hospital. Local emergency responders, hospital staff, state and federal representatives all rallied with the aim of saving the community's only hospital. The steps taken in Louisville and the deliberate restoration of these essential services offer a learning opportunity for all involved in healthcare disaster preparedness, response and recovery.

  8. The Prime Minister and the platypus: A paradox goes to war.

    Science.gov (United States)

    Lawrence, Natalie

    2012-03-01

    In February 1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain. This request can only be understood if placed in the context of Churchill's passion for exotic pets as well as the rich history of aristocratic menageries and live diplomatic gifts. Obtaining an animal hitherto unseen alive in Europe would have been a great zoological achievement for London Zoo and secured British authority in heated historical taxonomical debates. This zoological triumph, coupled with accomplishing an extravagant enterprise in the middle of war-time austerity would have boosted public morale. Most importantly, despite its death, the platypus, served as a token for mediating the soured relations between Australia and Britain. Churchill's platypus provides a unique case of animal collecting that incorporates effects on international diplomacy and public relations along with a great private eccentricity and passion. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Role of olmesartan in combination therapy in blood pressure control and vascular function

    Directory of Open Access Journals (Sweden)

    Carlos M Ferrario

    2010-08-01

    Full Text Available Carlos M Ferrario, Ronald D SmithWake Forest University School of Medicine, Winston-Salem, North Carolina, USAAbstract: Angiotensin receptor blockers have emerged as a first-line therapy in the management of hypertension and hypertension-related comorbidities. Since national and international guidelines have stressed the need to control blood pressure to <140/90 mmHg in uncomplicated hypertension and <130/80 mmHg in those with associated comorbidities such as diabetes or chronic kidney disease, these goal blood pressures can only be achieved through combination therapy. Of several drugs that can be effectively combined to attain the recommended blood pressure goals, fixed-dose combinations of angiotensin receptor blockers and the calcium channel blocker amlodipine provide additive antihypertensive effects associated with a safe profile and increased adherence to therapy. In this article, we review the evidence regarding the beneficial effects of renin–angiotensin system blockade with olmesartan medoxomil and amlodipine in terms of blood pressure control and improvement of vascular function and target organ damage.Keywords: amlodipine, angiotensin receptor blockers, angiotensin-converting enzyme 2, hypertension, renin–angiotensin system

  10. Quality of life issues and measurement in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Tan X

    2012-02-01

    Full Text Available Xi Tan1, Steven R Feldman2, Rajesh Balkrishnan11Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 2Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract: Psoriasis is a chronic immunologic disease characterized by red papules and plaques with a silver colored scale. The impact of psoriasis on patients’ overall quality of life is significant, broad, and deep, including effects on emotional wellbeing, psychological stress, self-esteem, relationship, work, social activities, financial burden, and even physical function. Although there are various measures available for assessing health-related quality of life (HRQoL in research studies, there is no consensus on which measure is best to use in clinical practice or for research comparing different treatments. Choosing treatments based on patients’ specific individual preferences, goal-orientation, and close, attentive cooperation between patients and their doctors may be an effective strategy that can be applied to improve patients’ quality of life.Keywords: treatment, health related quality of life, HRQoL

  11. Computer Security: Thirty years since "1984" - How close was Orwell to today’s interconnected world?

    CERN Multimedia

    Computer Security Team

    2014-01-01

    This year marks the 30th anniversary of the time depicted in the novel 1984, written by the visionary George Orwell in 1947/8, as well as the 25th anniversary of the World Wide Web being invented at CERN. To mark this occasion, both the Cineglobe Film Festival at CERN and the Latitude Festival in the UK are holding panel discussions on the technological and socio-cultural implications of our infinite connectedness in an age of internet surveillance: “How close is our world to that of Orwell's nightmare?”   The novel 1984 describes the fate of its protagonist Winston Smith and his love interest Julia. The setting is “Oceania”, one of three supra-nations at war with one another, a dictatorship blocking all free will (considered to be “thoughtcrime”), altering inconvenient historical truths (using “Newspeak”) and permanently monitoring its citizens (the origin of the phrase “Big Brother is watching ...

  12. STS-87 Payload Specialist Leonid Kadenyuk chats with NASA Administrator Daniel Goldin shortly after

    Science.gov (United States)

    1997-01-01

    STS-87 Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine (NSAU), at left, chats with NASA Administrator Daniel Goldin shortly after the landing of Columbia at Kennedy Space Center. Looking on is back-up Payload Specialist Yaroslav Pustovyi, also of NSAU. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34- minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; and Mission Specialists Winston Scott, Kalpana Chawla, Ph.D., and Takao Doi, Ph.D., of the National Space Development Agency of Japan. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

  13. Meaningful learning: The essential factor for conceptual change in limited or inappropriate propositional hierarchies leading to empowerment of learners

    Science.gov (United States)

    Novak, Joseph D.

    2002-07-01

    The construction and reconstruction of meanings by learners requires that they actively seek to integrate new knowledge with knowledge already in their cognitive structure. Ausubel's assimilation theory of cognitive learning has been shown to be effective in guiding research and instructional design to facilitate meaningful learning (Ausubel, The psychology of meaningful verbal learning, New York: Grune and Stratton, 1963; Educational psychology: A cognitive view, New York: Holt, Rinehart and Winston, 1968; The acquisition and retention of knowledge, Dordrecht: Kluwer, 2000). Gowin's Vee heuristic has been employed effectively to aid teachers and students in understanding the constructed nature of knowledge (Gowin, Educating, Ithaca, NY: Cornell University Press, 1981). Situated learning occurs when learning is by rote or at a lower level of meaningful learning. Concept mapping has been used effectively to aid meaningful learning with resulting modification of student's knowledge structures. When these knowledge structures are limited or faulty in some way, they may be referred to as Limited or Inappropriate Propositional Hierarchies (LIPH's). Conceptual change, or more accurately conceptual reconstrution, requires meaningful learning to modify LIPH's. Collaborative group learning facilitates meaningful learning and new knowledge construction. World-wide economic changes are forcing major changes in business and industry placing a premium on the power and value of knowledge and new knowledge production. These changes require changes in school and university education that centers on the nature and power of meaningful learning. New computer tools are available to facilitate teaching activities targeted at modifying LIPH's, and aiding meaningful learning in general.

  14. New developments in the treatment of rosacea – role of once-daily ivermectin cream

    Directory of Open Access Journals (Sweden)

    Cardwell LA

    2016-03-01

    Full Text Available Leah A Cardwell,1 Hossein Alinia,1 Sara Moradi Tuchayi,1 Steven R Feldman,1–31Department of Dermatology, Center for Dermatology Research, 2Department of Pathology, 3Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include immune abnormality, vascular abnormality, neurogenic dysregulation, presence of cutaneous microorganisms, UV damage, and skin barrier dysfunction. The role of ivermectin in the treatment of rosacea may be as an anti-inflammatory and anti-parasitic agent targeting Demodex mites. In comparing topical ivermectin and metronidazole, ivermectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Patients who received ivermectin 1% cream had an acceptable safety profile. Ivermectin is efficacious in decreasing inflammatory lesion counts and erythema. Keywords: papulopustular rosacea, topical ivermectin, metronidazole, azelaic acid, topical

  15. Preoperative psychological assessment of patients seeking weight-loss surgery: identifying challenges and solutions

    Directory of Open Access Journals (Sweden)

    Edwards-Hampton SA

    2015-11-01

    Full Text Available Shenelle A Edwards-Hampton,1 Sharlene Wedin2 1Department of General Surgery, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC, 2Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA Abstract: Preoperative psychosocial assessment is the standard of care for patients seeking weight-loss surgery (WLS. However, the assessment procedure varies widely by surgery site. Comprehensive assessments can provide a wealth of information that assists both the patient and the treatment team, anticipate and prepare for challenges associated with extensive behavioral and lifestyle changes that are required postsurgery. In this review, we provide an overview of the purpose of the preoperative psychosocial assessment and domains to be included. Challenges commonly identified in the assessment are discussed, including maladaptive eating behaviors, psychiatric comorbidities, and alcohol use. Potential solutions and approaches to these challenges are provided. Additionally, patient populations requiring special consideration are presented to include adolescents, those with cognitive vulnerabilities, and aging adults. Keywords: bariatric surgery, preoperative assessment, weight-loss surgery, challenges, adolescents, older adults, cognitive impairment, maladaptive eating, alcohol misuse

  16. Cigarette smuggling in Europe: who really benefits?

    Science.gov (United States)

    Joossens, L; Raw, M

    1998-01-01

    Cigarette smuggling, now on the increase, is so widespread and well organised that it poses a serious threat to public health. This threat comes from two principal directions. First, smuggling makes cigarettes available cheaply, thereby increasing consumption. A third of annual global exports go to the contraband market, representing an enormous impact on consumption, and thus causing an increase in the burden of disease, especially in poorer countries. It is also costing government treasuries thousands of millions of dollars in lost tax revenue. Second, the tobacco industry uses smuggling politically, lobbying governments to lower tax, arguing that smuggling is caused by price differences. This paper shows that the claimed correlation between high prices and high levels of smuggling does not exist in western Europe. In fact, countries such as Norway and Sweden, with expensive cigarettes, do not have a large smuggling problem, whereas countries in the south of Europe do. Cigarette smuggling is not caused principally by "market forces". It is mainly caused by fraud, by the illegal evasion of import duty. The cigarettes involved are not the cheap brands from southern European countries, for which there is no international market. It is the well-known international brands such as Marlboro and Winston. We propose much tighter regulation of cigarette trade, including an international transport convention, and a total ban on transit trade-sale by the manufacturers to dealers, who sell on to smugglers.

  17. The strokes that killed Churchill, Roosevelt, and Stalin.

    Science.gov (United States)

    Ali, Rohaid; Connolly, Ian D; Li, Amy; Choudhri, Omar A; Pendharkar, Arjun V; Steinberg, Gary K

    2016-07-01

    From February 4 to 11, 1945, President Franklin D. Roosevelt of the United States, Soviet Union Premier Joseph Stalin, and British Prime Minister Winston Churchill met near Yalta in Crimea to discuss how post-World War II (WWII) Europe should be organized. Within 2 decades of this conference, all 3 men had died. President Roosevelt died 2 months after the Yalta Conference due to a hemorrhagic stroke. Premier Stalin died 8 years later, also due to a hemorrhagic stroke. Finally, Prime Minister Churchill died 20 years after the conference because of complications due to stroke. At the time of Yalta, these 3 men were the leaders of the most powerful countries in the world. The subsequent deterioration of their health and eventual death had varying degrees of historical significance. Churchill's illness forced him to resign as British prime minister, and the events that unfolded immediately after his resignation included Britain's mismanagement of the Egyptian Suez Crisis and also a period of mistrust with the United States. Furthermore, Roosevelt was still president and Stalin was still premier at their times of passing, so their deaths carried huge political ramifications not only for their respective countries but also for international relations. The early death of Roosevelt, in particular, may have exacerbated post-WWII miscommunication between America and the Soviet Union-miscommunication that may have helped precipitate the Cold War.

  18. Understanding and using the history of social psychology.

    Science.gov (United States)

    Lubek, I

    2000-01-01

    Authors in this collection offer both critique and contextualist counterpoint to the standard, "official" histories of the field-successive editions of the Handbook of Social Psychology in 1954, 1968, 1985, and 1998. Unlike mainstream histories, the collected studies do not together constitute a seamless chronicle of continual progress for practitioners in a research area seeking social science status, viability, and legitimacy. Rather the authors focus on choice points, crises, and debates (some still ongoing), pay special heed to non-mainstream branches and voices, question numerous assumptions concerning the interrelationships among social psychological methodology, ontology (Danziger; MacMartin & Winston; Stam, Radtke, & Lubek), boundaries (Good), and individualisms (moral, political, and/or methodological). The specific contributions of Floyd and Gordon Allport are discussed from several perspectives as they helped define and shape and write the history of the field (Lubek & Apfelbaum; Parkovnick; Greenwood; Chung), and bridge it to neighboring areas (personality) and disciplines (psychology and sociology) (Nicholson; Barenbaum; Cherry). The constraints, origin myths, insensitivities, and omissions of standard histories are pointed out (Samelson), some partial correctives are advanced, and a more generative role for future historical studies is suggested. Copyright 2000 John Wiley & Sons, Inc.

  19. Advanced optical systems for ultra high energy cosmic rays detection

    Science.gov (United States)

    Gambicorti, L.; Pace, E.; Mazzinghi, P.

    2017-11-01

    A new advanced optical system is proposed and analysed in this work with the purpose to improve the photons collection efficiency of Multi-AnodePhotoMultipliers (MAPMT) detectors, which will be used to cover large focal surface of instruments dedicated to the Ultra High Energy Cosmic Rays (UHECRs, above 1019eV) and Ultra High Energy Neutrino (UHEN) detection. The employment of the advanced optical system allows to focus all photons inside the sensitive area of detectors and to improve the signal-to-noise ratios in the wavelength range of interest (300-400nm), thus coupling imaging and filtering capability. Filter is realised with a multilayer coating to reach high transparency in UV range and with a sharp cut-off outside. In this work the applications on different series of PMTs have been studied and results of simulations are shown. First prototypes have been realised. Finally, this paper proposes another class of adapters to be optically coupled on each pixel of MAPMT detector selected, consisting of non-imaging concentrators as Winston cones.

  20. Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

    Directory of Open Access Journals (Sweden)

    Ortega VE

    2015-01-01

    Full Text Available Victor E Ortega, Deborah A Meyers, Eugene R Bleecker Center for Genomics and Personalized Medicine Research, Pulmonary Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Human genetics research will be critical to the development of genetic profiles for personalized or precision medicine in asthma. Genetic profiles will consist of gene variants that predict individual disease susceptibility and risk for progression, predict which pharmacologic therapies will result in a maximal therapeutic benefit, and predict whether a therapy will result in an adverse response and should be avoided in a given individual. Pharmacogenetic studies of the glucocorticoid, leukotriene, and β2-adrenergic receptor pathways have focused on candidate genes within these pathways and, in addition to a small number of genome-wide association studies, have identified genetic loci associated with therapeutic responsiveness. This review summarizes these pharmacogenetic discoveries and the future of genetic profiles for personalized medicine in asthma. The benefit of a personalized, tailored approach to health care delivery is needed in the development of expensive biologic drugs directed at a specific biologic pathway. Prior pharmacogenetic discoveries, in combination with additional variants identified in future studies, will form the basis for future genetic profiles for personalized tailored approaches to maximize therapeutic benefit for an individual asthmatic while minimizing the risk for adverse events. Keywords: asthma, pharmacogenetics, response heterogeneity, single nucleotide polymorphism, genome-wide association study

  1. The association of age of toilet training and dysfunctional voiding

    Directory of Open Access Journals (Sweden)

    Hodges SJ

    2014-10-01

    Full Text Available Steve J Hodges, Kyle A Richards, Ilya Gorbachinsky, L Spencer KraneDepartment of Urology, Wake Forest University, Winston-Salem, NC, USAObjective: To determine whether age of toilet training is associated with dysfunctional voiding in children.Materials and methods: We compared patients referred to the urologic clinics for voiding dysfunction with age-matched controls without urinary complaints. Characteristics including age and reason for toilet training, method of training, and encopresis or constipation were compared between both groups.Results: Initiation of toilet training prior to 24 months and later than 36 months of age were associated with dysfunctional voiding. However, dysfunctional voiding due to late toilet training was also associated with constipation.Conclusion: Dysfunctional voiding may be due to delayed emptying of the bowel and bladder by children. The symptoms of dysfunctional voiding are more common when toilet training early, as immature children may be less likely to empty in a timely manner, or when training late due to (or in association with constipation.Keywords: voiding dysfunction, constipation

  2. Self-management in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Pathak SN

    2014-07-01

    Full Text Available Swetha Narahari Pathak,1 Pauline L Scott,1 Cameron West,1 Steven R Feldman,1–3 1Center for Dermatology Research, Departments of Dermatology, 2Center for Dermatology Research, Departments of Pathology, 3Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Psoriasis is a chronic inflammatory disorder effecting the skin and joints. Additionally, multiple comorbidities exist, including cardiovascular, metabolic, and psychiatric. The chronic nature of psoriasis is often frustrating for both patients and physicians alike. Many options for treatment exist, though successful disease management rests largely on patients through the application of topical corticosteroids, Vitamin D analogs, and calcineurin inhibitors, amongst others and the administration of systemic medications such as biologics and methotrexate. Phototherapy is another option that also requires active participation from the patient. Many barriers to effective self-management of psoriasis exist. Successful treatment requires the establishment of a strong doctor-patient relationship and patient empowerment in order to maximize adherence to a treatment regimen and improve outcomes. Improving patient adherence to treatment is necessary in effective self-management. Many tools exist to educate and empower patients, including online sources such as the National Psoriasis Foundation and online support group, Talk Psoriasis, amongst others. Effective self management is critical in decreasing the physical burden of psoriasis and mitigating its multiple physical, psychological, and social comorbidities, which include obesity, cardiovascular disease, alcohol dependence, depression, anxiety, and social anxiety. Keywords: psoriasis, adherence, self management, compliance

  3. Pulsed Electromagnetic Acceleration of Plasma: A Review

    Science.gov (United States)

    Thio, Y. C. Francis; Turchi, Peter J.; Markusic, Thomas E.; Cassibry, Jason T.; Sommer, James; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    Much have been learned in the acceleration mechanisms involved in accelerating a plasma electromagnetically in the laboratory over the last 40 years since the early review by Winston Bostik of 1963, but the accumulated understanding is very much scattered throughout the literature. This literature extends back at least to the early sixties and includes Rosenbluth's snowplow model, discussions by Ralph Lovberg, Colgate's boundary-layer model of a current sheet, many papers from the activity at Columbia by Robert Gross and his colleagues, and the relevant, 1-D unsteady descriptions developed from the U. of Maryland theta-pinch studies. Recent progress on the understanding of the pulsed penetration of magnetic fields into collisionless or nearly collisionless plasmas are also be reviewed. Somewhat more recently, we have the two-dimensional, unsteady results in the collisional regime associated with so-called wall-instability in large radius pinch discharges and also in coaxial plasma guns (e.g., Plasma Flow Switch). Among other things, for example, we have the phenomenon of a high- density plasma discharge propagating in a cooaxial gun as an apparently straight sheet (vs paraboloid) because mass re-distribution (on a microsecond timescale) compensates for the 1/r- squared variation of magnetic pressure. We will attempt to collate some of this vast material and bring some coherence tc the development of the subject.

  4. A Critical Study of Selected Political Elites' Discourse in English

    Directory of Open Access Journals (Sweden)

    Biook Behnam

    2008-02-01

    Full Text Available This study explored how political elites can contribute to power enactment through using language. It started with a theoretical overview of Critical Discourse Analysis (CDA, and then presented a corpus consisting of speeches of eight political elites, namely, Malcolm X, Noam Chomsky, Martin Luther King, Josef Stalin, Vladimir Lenin, Winston Churchill, J.F. Kennedy and Adolph Hitler. This study analyzed speeches in terms of figures of' speech, and interpreted them from the point of view of CDA using the framework introduced by Fairclough (1989 as a three-dimensional approach to the study of discourse (Description, Interpretation, Explanation and van Dijk (2004 as the theory of critical context analysis.. Speech figures are classified in this study into six main categories as Comparison, Grammar, Meaning, Parenthesis, Repetition and Rhetoric. The result of analyses reveals that while there are differences in the type and degree of speech figures employed by our selected individual political elites, there is one striking pattern which is common among all speeches: the frequent use of figures of Grammar, Repetition and Rhetoric

  5. Assessing balance through the use of a low-cost head-mounted display in older adults: a pilot study

    Directory of Open Access Journals (Sweden)

    Saldana SJ

    2017-08-01

    Full Text Available Santiago J Saldana,1 Anthony P Marsh,2 W Jack Rejeski,2 Jack K Haberl,2 Peggy Wu,3 Scott Rosenthal,4 Edward H Ip1 1Department of Biostatistical Sciences, Wake Forest School of Medicine, 2Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, 3Research and Development, Smart Information Flow Technologies, Minneapolis, MN, 4Wake Forest School of Medicine, Winston-Salem, NC, USA Introduction: As the population ages, the prevention of falls is an increasingly important public health problem. Balance assessment forms an important component of fall-prevention programs for older adults. The recent development of cost-effective and highly responsive virtual reality (VR systems means new methods of balance assessment are feasible in a clinical setting. This proof-of-concept study made use of the submillimeter tracking built into modern VR head-mounted displays (VRHMDs to assess balance through the use of visual–vestibular conflict. The objective of this study was to evaluate the validity, acceptability, and reliability of using a VRHMD to assess balance in older adults.Materials and methods: Validity was assessed by comparing measurements from the VRHMD to measurements of postural sway from a force plate. Acceptability was assessed through the use of the Simulator Sickness Questionnaire pre- and postexposure to assess possible side effects of the visual–vestibular conflict. Reliability was assessed by measuring correlations between repeated measurements 1 week apart. Variables of possible importance that were found to be reliable (r≥0.9 between tests separated by a week were then tested for differences compared to a control group. Assessment was performed as a cross-sectional single-site community center-based study in 13 older adults (≥65 years old, 80.2±7.3 years old, 77% female, five at risk of falls, eight controls. The VR balance assessment consisted of four modules: a baseline module, a reaction module, a

  6. Promoting physical activity for elders with compromised function: the Lifestyle Interventions and Independence for Elders (LIFE Study physical activity intervention

    Directory of Open Access Journals (Sweden)

    Rejeski WJ

    2013-09-01

    Full Text Available W Jack Rejeski,1 Robert Axtell,2 Roger Fielding,3 Jeffrey Katula,1 Abby C King,4 Todd M Manini,5 Anthony P Marsh,1 Marco Pahor,5 Alvito Rego,6 Catrine Tudor-Locke,7 Mark Newman,8 Michael P Walkup,9 Michael E Miller9  On behalf of the LIFE Study Investigator Group 1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, 2Exercise Science Department, Southern Connecticut State University, New Haven, CT, 3Nutrtion, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 4Department of Health Research and Policy and Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, 5Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, 6Department of Internal Medicine, Northwestern School of Medicine, Chicago, IL, 7Pennington Biomedical Research Center, Baton Rouge, LA, 8Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 9Department of Biostatistical Sciences, Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA Abstract: The Lifestyle Interventions and Independence for Elders (LIFE Study is a Phase III randomized controlled clinical trial (Clinicaltrials.gov identifier: NCT01072500 that will provide definitive evidence regarding the effect of physical activity (PA on major mobility disability in older adults (70–89 years old who have compromised physical function. This paper describes the methods employed in the delivery of the LIFE Study PA intervention, providing insight into how we promoted adherence and monitored the fidelity of treatment. Data are presented on participants' motives and self-perceptions at the onset of the trial along with accelerometry data on patterns of PA during exercise training. Prior to the onset of training, 31.4% of

  7. How field monitoring of green infrastructure stormwater practices has led to changes in North Carolina's Stormwater BMP design manual

    Science.gov (United States)

    Hunt, W. F.; Winston, R. J.

    2011-12-01

    Green Infrastructure stormwater management is comprised of many biologically-based stormwater treatment practices. Two of which, bioretention and level spreader- vegetative filter strips, have been extensively studied at over 10 different field locations across North Carolina by NC State University. The result of this research has been dramatic changes to the state of North Carolina's stormwater BMP Design Manual, which now allows a greater amount of flexibility for the design of each practice than most other design manuals. The purpose of this presentation is to present a summary of research conducted in North Carolina and associate that research with specific changes made in the state's design guidance for both bioretention (Table 1) and level spreader- vegetated filter strip systems (Table 2). Among the changes are type of vegetation, ratio of hydraulic loading, underdrainage configuration, and fill media selection. References (in print) associated with the tables are listed below: Hathaway, J.M. and W.F. Hunt. 2008. Field Evaluation of Level Spreaders in the Piedmont of North Carolina. Journal of Irrigation and Drainage Engineering, 134(4):538-542. Hunt, W.F., A.R. Jarrett, J.T. Smith, L.J. Sharkey. 2006. Evaluating Bioretention Hydrology and Nutrient Removal at Three Field Sites in North Carolina. Journal of Irrigation and Drainage Engineering, 132 (6): 600-608. Hunt, W.F., J.M. Hathaway, R.J. Winston, and S.J. Jadlocki. 2010. Runoff Volume Reduction by a Level Spreader - Vegetated Filter Strip System in Suburban Charlotte, NC. Journal of Hydrologic Engineering, 15(6): 399-503. Jones, M.P. and W.F. Hunt. 2009. Bioretention Impact on Runoff Temperature in Trout Sensitive Waters. Journal of Environmental Engineering, 135(8): 577-585. Li, H., L.J. Sharkey, W.F. Hunt, A.P. Davis. 2009. Mitigation of Impervious Surface Hydrology using Bioretention in North Carolina and Maryland. Journal of Hydrologic Engineering, 14(4): 407-415. Line, D.E. and W.F. Hunt. 2009

  8. What Followers Want from Their Leaders: An Analytical Perspectivas Lo que los seguidores esperan de sus líderes: Una perspectiva analítica

    Directory of Open Access Journals (Sweden)

    Rodrigo Zárate Torres

    2009-12-01

    Full Text Available Many researchers and others interested in the field of leadership have written about the characteristics and styles of leadership; however, few have written about what followers want from their leaders. This paper addresses the issue of what followers desire in those they follow, it will assert that the basic characteristics followers want from their leaders are Honesty, Forward-Looking, Inspiring, and Competency. Also, followers want to trust in their leaders and they want leaders who care about them, which is shown in the leaders seeing the followers as partners. This paper also compares what international studies found about this leader-follower dynamic with a study made by Colegio de Estudios Superiores de Administracion - CESA where leaders were asked about the main characteristics of an organizational leader. The analysis shows that followers want to commit to their leaders. They want to know that there is a relationship between them. As mentioned by Winston (2002, the relationship between leader and follower has to have the same commitment that exists between husband and wife. In addition, this paper presents the conceptual framework of the analysis and the leadership models that fit more with what followers want from their leaders which are Transformational and Charismatic leadership.Muchos investigadores y otros interesados en el campo del liderazgo han escrito acerca de las características y estilos de liderazgo; no obstante, pocos han tratado sobre aquello que los seguidores quieren de sus líderes. El presente artículo aborda esta cuestión y afirma que las características básicas que los seguidores quieren de sus líderes son: Honestidad, visión progresista, inspiración y competencia. Además, los seguidores quieren confiar en sus líderes y que estos se preocupen de ellos, aspecto que se evidencia cuando los líderes ven a sus seguidores como socios. El documento también compara los resultados de estudios internacionales

  9. Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections

    Directory of Open Access Journals (Sweden)

    Jones TM

    2016-06-01

    Full Text Available Travis M Jones,1,2 Steven W Johnson,1,3 V Paul DiMondi,1,4 Dustin T Wilson,1,2 1Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, 2Department of Pharmacy, Duke University Hospital, Durham, 3Department of Pharmacy, Forsyth Medical Center, Novant Health, Winston-Salem, 4Department of Pharmacy, Durham VA Medical Center, Durham, NC, USA Abstract: JNJ-Q2 is a novel, fifth-generation fluoroquinolone that has excellent in vitro and in vivo activity against a variety of Gram-positive and Gram-negative organisms. In vitro studies indicate that JNJ-Q2 has potent activity against pathogens responsible for acute bacterial skin and skin structure infections (ABSSSI and community-acquired bacterial pneumonia (CABP, such as Staphylococcus aureus and Streptococcus pneumoniae. JNJ-Q2 also has been shown to have a higher barrier to resistance compared to other agents in the class and it remains highly active against drug-resistant organisms, including methicillin-resistant S. aureus, ciprofloxacin-resistant methicillin-resistant S. aureus, and drug-resistant S. pneumoniae. In two Phase II studies, the efficacy of JNJ-Q2 was comparable to linezolid for ABSSSI and moxifloxacin for CABP. Furthermore, JNJ-Q2 was well tolerated, with adverse event rates similar to or less than other fluoroquinolones. With an expanded spectrum of activity and low potential for resistance, JNJ-Q2 shows promise as an effective treatment option for ABSSSI and CABP. Considering its early stage of development, the definitive role of JNJ-Q2 against these infections and its safety profile will be determined in future Phase III studies. Keywords: JNJ-Q2, fluoroquinolone, ABSSSI, CABP, MRSA

  10. Development of a composite large-size SiPM (assembled matrix) based modular detector cluster for MAGIC

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, A., E-mail: ahahn@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Mazin, D., E-mail: mazin@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa City, Chiba 277–8582 (Japan); Bangale, P., E-mail: priya@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Dettlaff, A., E-mail: todettl@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Fink, D., E-mail: fink@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Grundner, F., E-mail: grundner@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Haberer, W., E-mail: haberer@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Maier, R., E-mail: rma@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); and others

    2017-02-11

    The MAGIC collaboration operates two 17 m diameter Imaging Atmospheric Cherenkov Telescopes (IACTs) on the Canary Island of La Palma. Each of the two telescopes is currently equipped with a photomultiplier tube (PMT) based imaging camera. Due to the advances in the development of Silicon Photomultipliers (SiPMs), they are becoming a widely used alternative to PMTs in many research fields including gamma-ray astronomy. Within the Otto-Hahn group at the Max Planck Institute for Physics, Munich, we are developing a SiPM based detector module for a possible upgrade of the MAGIC cameras and also for future experiments as, e.g., the Large Size Telescopes (LST) of the Cherenkov Telescope Array (CTA). Because of the small size of individual SiPM sensors (6 mm×6 mm) with respect to the 1-inch diameter PMTs currently used in MAGIC, we use a custom-made matrix of SiPMs to cover the same detection area. We developed an electronic circuit to actively sum up and amplify the SiPM signals. Existing non-imaging hexagonal light concentrators (Winston cones) used in MAGIC have been modified for the angular acceptance of the SiPMs by using C++ based ray tracing simulations. The first prototype based detector module includes seven channels and was installed into the MAGIC camera in May 2015. We present the results of the first prototype and its performance as well as the status of the project and discuss its challenges. - Highlights: • The design of the first SiPM large-size IACT pixel is described. • The simulation of the light concentrators is presented. • The temperature stability of the detector module is demonstrated. • The calibration procedure of SiPM device in the field is described.

  11. Undergraduate Research Experiences in Support of Dryland Monitoring: Field and Satellite Remote Sensing of Change in Savanna Structure, Biomass, and Carbon after Prescribed Fires

    Science.gov (United States)

    Washington-Allen, R. A.; Twidwell, D. L., Jr.; Mendieta, V. P.; Delgado, A.; Redman, B.; Trollope, W. S.; Trollope, L.; Govender, N.; Smit, I.; Popescu, S. C.; de Bruno Austin, C.; Reeves, M. C.

    2009-12-01

    The status and trend of degradation in the world’s Drylands, that support over 1.2 billion people, is unknown because monitoring & assessment has not occurred on a globally consistent basis and skilled personnel with a cultivated interest in natural resource science and management are lacking. A major monitoring dataset is the 37-year Landsat data archive that has been released free to the world, but this dataset requires persons who understand how to process and interpret this and similar datasets applicable to the desertification problem. The College of Agriculture & Life Sciences (COALS) at Texas A&M University (TAMU) has an initiative to provide undergraduates with both international and research experiences. The lead author used start-up money, USFS project funds for livestock footprint studies in the US, and seed money from COALS to 1) develop academic mentor contacts in Mozambique, Namibia, Botswana, South Africa, and Tunisia to prepare a National Science Foundation Research Experience for Undergraduates (NSF-REU) Site proposal and 2) launch a pilot REU for two TAMU undergraduate students. Mr. Delgado and Mr. Redman received lidar processing and visualization, field survey training on global positioning systems (GPS), terrestrial LIDAR, and ground penetrating radar technologies and conducted carbon change studies by collecting pre- and post-fire laser scans on experimental burn (EPB) sites in Texas and South Africa. Mr. Redman also developed GIS databases of Landsat timeseries for these EPBs and others in southern Africa. Mr. Delgado participated in the Savanna Fire Ignition Research Experiment (SavFIRE) in Kruger National Park (KNP) by collected laser scan data on 3 EPBs. He also received mentoring from Dr. Winston Trollope, a prominent fire ecologist, and Mr. Chris Austin both of Working with Fire International and Navashni Govender, KNP’s Fire Ecologist. He also was an active participant in a NASA sponsored workshop on remote sensing of global

  12. Surgical travellers: tapestry to Bayeux.

    Science.gov (United States)

    Hedley-Whyte, John; Milamed, Debra R

    2014-09-01

    The planning for surgery in war was revisited in 1937 when Ian Fraser was elected a member of the Surgical Travellers. At their 1938 Surgical Travellers meeting in Vienna, Ian and Eleanor Fraser were evicted from their hotel room by the Nazis. The 1939 meeting in Belfast discussed the organization of surgery and the conduct of Emergency Medical Service Hospitals in the United Kingdom; the vast majority were to be under civilian government and military control. From 1943 lengthy and informative organizational meetings were held at least monthly under the chairmanship of Sir Alexander Hood, KBE, Head of the RAMC. Surgical Consultants, now Major Generals, Brigadiers or Full Colonels in the British and U.S. Armies stationed in the UK, prepared for the invasion of Europe. The allocation of medical, surgical, nursing and auxiliary responsibilities was delineated. Liaison with the RAF and US Army Air Force was close as it was with the proposed leaders, Ulstermen Brooke and Montgomery. Montgomery chose Arthur Porritt as Surgeon in Chief to Supreme Headquarters Allied Expeditionary Force (SHAEF), and Eisenhower, General Albert W. Kenner. Just after D-Day, Porritt met Ian Fraser, who had waded in on Arromanches Beach. The triage and evacuation plans for Allied casualties had been controversial, particularly as regards Landing Ship Tanks (LSTs). The dispute with the Hood-selected surgeons on one side, against medical and surgical deployment of LSTs, and Admiral Ernest King and Winston Churchill on the other, favouring LST use for surgery and evacuation. King and Churchill were correct but total Allied air superiority allowed wide use of many of the Allies' Dakotas; 10,000 DC-3s were eventually in service. Supported by forty Allied combat planes to each Luftwaffe, the dispute about Landing Ship Tank use in about a fortnight became moot. The multifaceted role of the Princess Royal in the Emergency Medical Services of the United Kingdom and her close liaison with the Consultant

  13. Spotlight on brimonidine topical gel 0.33% for facial erythema of rosacea: safety, efficacy, and patient acceptability

    Directory of Open Access Journals (Sweden)

    Anderson MS

    2017-07-01

    Full Text Available Michael S Anderson,1 Anish Nadkarni,1 Leah A Cardwell,1 Hossein Alinia,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, 2Department of Pathology, 3Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Background: Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema. Objective: To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel.Methods: A PubMed search was performed using the terms brimonidine 0.33% gel, rosacea, safety, efficacy, and acceptability. Peer-reviewed clinical trials and case reports from 2012 to 2016 were screened for inclusion of safety, efficacy, and/or patient acceptability data.Results: Brimonidine topical gel 0.33% is associated with mild, transient skin-related adverse reactions. Efficacy may be achieved within 30 minutes of administration with maximal reductions in erythema 3–6 hours after administration. Patient satisfaction with use of brimonidine topical gel is superior to vehicle gel for facial appearance, treatment effect, facial redness, and daily control of facial redness.Limitations: Studies were typically limited to 1-year follow-up. Only one study has examined the use of brimonidine topical gel in combination with other rosacea and acne medications.Discussion: Brimonidine topical gel 0.33% is a safe, effective, and patient-accepted treatment for facial erythema of rosacea. Keywords: patient satisfaction, adverse reactions, side effects 

  14. The embodied and relational nature of the mind: implications for clinical interventions in aging individuals and populations

    Directory of Open Access Journals (Sweden)

    Rejeski WJ

    2013-06-01

    Full Text Available W Jack Rejeski,1 Lise Gauvin2 1Department of Health and Exercise Science and Department of Geriatric Medicine, Wake Forest University, Winston-Salem, NC, USA; 2Research Center of the University of Montréal Hospital Center, Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada Abstract: Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and information flow; they codetermine how we think, feel, and behave both individually and collectively. In addition to direct experience, evidence supports the view that stimuli embedded within past memories trigger multimodal simulations throughout the body and brain to literally recreate lived experience. In this paper, we review empirical support for the concept of an embodied and relational mind and then reflect on the implications of this perspective for clinical interventions in aging individuals and populations. Data suggest that environmental influences literally “get under the skin” with aging; that musculoskeletal and visceral sensations become more prominent in activities of the mind due to aging biological systems and chronic disease. We argue that conceiving the mind as embodied and relational will grow scientific inquiry in aging, transform how we think about the self-system and well-being, and lead us to rethink health promotion interventions aimed at aging individuals and populations. Keywords: behavior change, gerontology, disablement, well-being, embodiment

  15. The coefficient of friction of chrysotile gouge at seismogenic depths

    Science.gov (United States)

    Moore, Diane E.; Lockner, D.A.; Tanaka, H.; Iwata, K.

    2004-01-01

    We report new strength data for the serpentine mineral chrysotile at effective normal stresses, ??sn between 40 and 200 MPa in the temperature range 25??-280??C. Overall, the coefficient of friction, ?? (= shear stress/effective normal stress) of water-saturated chrysotile gouge increases both with increasing temperature and ??sn, but the rates vary and the temperature-related increases begin at ???100??C. As a result, a frictional strength minimum (?? = 0.1) occurs at low ??sn at about 100??C. Maximum strength (?? = 0.55) results from a combination of high normal stress and high temperature. The low-strength region is characterized by velocity strengthening and the high-strength region by velocity-weakening behavior. Thoroughly dried chrysotile has ?? = 0.7 and is velocity-weakening. The frictional properties of chrysolite can be explained in its tendency to adsorb large amounts of water that acts as a lubricant during shear. The water is progressively driven off the fiber surfaces with increasing temperature and pressure, causing chrysotile to approach its dry strength. Depth profiles for a chrysotile-lined fault constructed from these data would pass through a strength minimum at ???3 km depth, where sliding should be stable. Below that depth, strength increases rapidly as does the tendency for unstable (seismic) slip. Such a trend would not have been predicted from the room-temperature data. These results therefore illustrate the potential hazards of extrapolating room-temperature friction data to predict fault zone behavior at depth. This depth profile for chrysotile is consistent with the pattern of slip on the Hayward fault, which creeps aseismically at shallow depths but which may be locked below 5 km depth. ?? 2004 by V. H. Winston and Son, Inc. All rights reserved.

  16. SU-G-TeP2-04: Comprehensive Machine Isocenter Evaluation with Separation of Gantry, Collimator, and Table Variables

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, S [Southeast Missouri Hospital, Cape Girardeau, MO (United States); Clements, C [Radiological Imaging Technology, Colorado Springs, CO (United States); Hyer, D; Nixon, E [University Of Iowa, Iowa City, IA (United States); Martin, E; Wang, B [University of Louisville, Louisville, KY (United States); Jani, S [Sharp Memorial Hospital, San Diego, CA (United States); Gossman, M [Tri-State Regional Cancer Center, Ashland, KY (United States)

    2016-06-15

    Purpose: To develop and demonstrate application of a method that characterizes deviation of linac x-ray beams from the centroid of the volumetric radiation isocenter as a function of gantry, collimator, and table variables. Methods: A set of Winston-Lutz ball-bearing images was used to determine the gantry radiation isocenter as the midrange of deviation values resulting from gantry and collimator rotation. Also determined were displacement of table axis from gantry isocenter and recommended table axis adjustment. The method, previously reported, has been extended to include the effect of collimator walkout by obtaining measurements with 0 and 180 degree collimator rotation for each gantry angle. Twelve images were used to characterize the volumetric isocenter for the full range of available gantry, collimator, and table rotations. Results: Three Varian True Beam, two Elekta Infinity and four Versa HD linacs at five institutions were tested using identical methodology. Varian linacs exhibited substantially less deviation due to head sag than Elekta linacs (0.4 mm vs. 1.2 mm on average). One linac from each manufacturer had additional isocenter deviation of 0.3 to 0.4 mm due to jaw instability with gantry and collimator rotation. For all linacs, the achievable isocenter tolerance was dependent on adjustment of collimator position offset, transverse position steering, and alignment of the table axis with gantry isocenter, facilitated by these test results. The pattern and magnitude of table axis wobble vs. table angle was reproducible and unique to each machine. Conclusion: This new method provides a comprehensive set of isocenter deviation values including all variables. It effectively facilitates minimization of deviation between beam center and target (ball-bearing) position. This method was used to quantify the effect of jaw instability on isocenter deviation and to identify the offending jaw. The test is suitable for incorporation into a routine machine QA

  17. SU-E-T-54: A New Method for Optimizing Radiation Isocenter for Linac-Based SRS

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, S [Southeast Missouri Hospital, Cape Girardeau, MO (United States); Hyer, D; Nixon, E [University Of Iowa, Iowa City, IA (United States)

    2015-06-15

    Purpose: To develop a new method to minimize deviation of linac x-ray beams from the centroid of the volumetric radiation isocenter for all combinations of gantry and table angle. Methods: A set of ball-bearing (Winston-Lutz) images was used to determine the gantry radiation isocenter as the midrange of deviation values. Deviations in the cross-plane direction were minimized by calibration of MLC leaf position offset, and by adjusting beam position steering for each energy. Special attention was also paid to matching the absolute position of isocenter across all energies by adjusting position steering in the gun-target axis. Displacement of table axis from the gantry isocenter, and recommended table axis adjustment for contemporary Elekta linacs, was also determined. Eight images were used to characterize the volumetric isocenter for the full range of gantry and table rotations available. Tabulation of deviation for each beam was used to test compliance with isocenter tolerance. Results: Four contemporary Elekta linacs were evaluated and the radius in the gun-target axis of the radiation isocenter was 0.5 to 0.7 mm. After beam steering adjustment, the radius in the cross-plane direction was typically 0.2 to 0.4 mm. Position matching between energies can be reduced to 0.28 mm. Maximum total deviation was 0.68 to 1.07 mm, depending primarily on the effect of systematic table axis wobble with rotation. Conclusion: This new method effectively facilitates minimization of deviation between beam center and target position. The test, which requires a few minutes to perform, can be easily incorporated into a routine machine QA program. A tighter radiation isocenter for contemporary Elekta linacs would require reducing the effect of gantry arm flex and/or table axis wobble that are the two main components of deviation from the designated isocenter point.

  18. Modeling the residential infiltration of outdoor PM(2.5) in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air).

    Science.gov (United States)

    Allen, Ryan W; Adar, Sara D; Avol, Ed; Cohen, Martin; Curl, Cynthia L; Larson, Timothy; Liu, L-J Sally; Sheppard, Lianne; Kaufman, Joel D

    2012-06-01

    Epidemiologic studies of fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM(2.5))] typically use outdoor concentrations as exposure surrogates. Failure to account for variation in residential infiltration efficiencies (F(inf)) will affect epidemiologic study results. We aimed to develop models to predict F(inf) for > 6,000 homes in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air), a prospective cohort study of PM(2.5) exposure, subclinical cardiovascular disease, and clinical outcomes. We collected 526 two-week, paired indoor-outdoor PM(2.5) filter samples from a subset of study homes. PM(2.5) elemental composition was measured by X-ray fluorescence, and F(inf) was estimated as the indoor/outdoor sulfur ratio. We regressed F(inf) on meteorologic variables and questionnaire-based predictors in season-specific models. Models were evaluated using the R² and root mean square error (RMSE) from a 10-fold cross-validation. The mean ± SD F(inf) across all communities and seasons was 0.62 ± 0.21, and community-specific means ranged from 0.47 ± 0.15 in Winston-Salem, North Carolina, to 0.82 ± 0.14 in New York, New York. F(inf) was generally greater during the warm (> 18°C) season. Central air conditioning (AC) use, frequency of AC use, and window opening frequency were the most important predictors during the warm season; outdoor temperature and forced-air heat were the best cold-season predictors. The models predicted 60% of the variance in 2-week F(inf), with an RMSE of 0.13. We developed intuitive models that can predict F(inf) using easily obtained variables. Using these models, MESA Air will be the first large epidemiologic study to incorporate variation in residential F(inf) into an exposure assessment.

  19. Poster — Thur Eve — 55: An automated XML technique for isocentre verification on the Varian TrueBeam

    International Nuclear Information System (INIS)

    Asiev, Krum; Mullins, Joel; DeBlois, François; Liang, Liheng; Syme, Alasdair

    2014-01-01

    Isocentre verification tests, such as the Winston-Lutz (WL) test, have gained popularity in the recent years as techniques such as stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments are more commonly performed on radiotherapy linacs. These highly conformal treatments require frequent monitoring of the geometrical accuracy of the isocentre to ensure proper radiation delivery. At our clinic, the WL test is performed by acquiring with the EPID a collection of 8 images of a WL phantom fixed on the couch for various couch/gantry angles. This set of images is later analyzed to determine the isocentre size. The current work addresses the acquisition process. A manual WL test acquisition performed by and experienced physicist takes in average 25 minutes and is prone to user manipulation errors. We have automated this acquisition on a Varian TrueBeam STx linac (Varian, Palo Alto, USA). The Varian developer mode allows the execution of custom-made XML script files to control all aspects of the linac operation. We have created an XML-WL script that cycles through each couch/gantry combinations taking an EPID image at each position. This automated acquisition is done in less than 4 minutes. The reproducibility of the method was verified by repeating the execution of the XML file 5 times. The analysis of the images showed variation of the isocenter size less than 0.1 mm along the X, Y and Z axes and compares favorably to a manual acquisition for which we typically observe variations up to 0.5 mm

  20. SU-G-TeP4-12: Individual Beam QA for a Robotic Radiosurgery System Using a Scintillator Cone

    Energy Technology Data Exchange (ETDEWEB)

    McGuinness, C; Descovich, M; Sudhyadhom, A [University of California San Francisco, San Francisco, CA (United States)

    2016-06-15

    Purpose: The targeting accuracy of the Cyberknife system is measured by end-to-end tests delivering multiple isocentric beams to a point in space. While the targeting accuracy of two representative beams can be determined by a Winston-Lutz-type test, no test is available today to determine the targeting accuracy of each clinical beam. We used a scintillator cone to measure the accuracy of each individual beam. Methods: The XRV-124 from Logos Systems Int’l is a scintillator cone with an imaging system that is able to measure individual beam vectors and a resulting error between planned and measured beam coordinates. We measured the targeting accuracy of isocentric and non-isocentric beams for a number of test cases using the Iris and the fixed collimator. The average difference between plan and measured beam position was 0.8–1.2mm across the collimator sizes and plans considered here. The max error for a single beam was 2.5mm for the isocentric plans, and 1.67mm for the non-isocentric plans. The standard deviation of the differences was 0.5mm or less. Conclusion: The CyberKnife System is specified to have an overall targeting accuracy for static targets of less than 0.95mm. In E2E tests using the XRV124 system we measure average beam accuracy between 0.8 to 1.23mm, with maximum of 2.5mm. We plan to investigate correlations between beam position error and robot position, and to quantify the effect of beam position errors on patient specific plans. Martina Descovich has received research support and speaker honoraria from Accuray.

  1. SU-F-J-53: A 3D Printed Phantom for the Use of Daily Quality Assurance Alignment Tests

    Energy Technology Data Exchange (ETDEWEB)

    Woods, K; Ayan, A; Woollard, J; Gardner, N; Gupta, N [Ohio State University Columbus, OH (United States)

    2016-06-15

    Purpose: To discuss experiences and results for a 3D printed QA phantom used for daily alignment purposes for a six degrees-of-freedom (6DoF) table Methods: A 3D model was created using a fused deposition modeling (FDM) printer using free online computer-aided design (CAD) software. The model has been under use for daily QA alignment tests for a 6DoF couch. An aligned and angled baseplate were also printed in order to introduce known angles for 6DoF corrections during image-guidance. Unique registration contours were created on the faces of the phantom in order to achieve a better cone-beam computed tomography (CBCT) match using an auto-registration algorithm. A BB was also introduced at the center of the phantom in order to deliver an integrated daily Winston-Lutz (WL) test. Translational, rotational, and WL results were tabulated over one month. Results: The ’honeycomb’ structure of the print was apparent in the EPID images for the WL test, which affected the results of the analysis software. This was fixed by inserting a cube made of polyoxymethylene within the 3D phantom that encompass the BB. Auto-registration results for the three translational and three rotational from a known offset to the BB isocenter consistently fell within 1 mm and 0.2°, respectively. WL tests resulted in an average of 0.71 ± 0.14 mm. Conclusion: 3D printed models allow for accurate builds that can be customized to a variety of clinical needs. Results from translational, rotational, and WL show consistent results over a month’s time. Given its relatively cheap and streamlined workflow, 3D printing could be implemented into any clinic looking to create customized phantoms.

  2. “And they told two friends…and so on”: RJ Reynolds’ viral marketing of Eclipse and its potential to mislead the public

    Science.gov (United States)

    Anderson, S J; Ling, P M

    2010-01-01

    Objective To explore viral marketing strategies for Eclipse cigarettes used by the RJ Reynolds Company (Winston-Salem, North Carolina, USA). Methods Analysis of previously secret tobacco industry documents and multimedia materials. Results The failure of RJ Reynolds’ (RJR) 1988 “smokeless” cigarette, Premier, was in part due to widespread bad word of mouth about the product’s flavour, quality and difficulty of use. In 1994 RJR introduced an updated version of Premier, the ostensibly “reduced risk” Eclipse cigarette. RJR developed viral marketing channels to promote Eclipse using (1) exploratory interviews to motivate consumers to spread the word about Eclipse prior to market release, (2) promotional videos featuring positive feedback from test group participants to portray majority consensus among triers, (3) “Tupperware”-like parties for Eclipse where participants received samples to pass around in their social circles and (4) the Eclipse website’s bulletin board as a forum for potential users to discuss the brand in their own words. These strategies targeted the brand’s likeliest adopters, recruited informal and credible representatives of the product unaffiliated with RJR, and controlled the information spread about the product. Conclusions Viral marketing techniques may be particularly useful to promote new tobacco products such as Eclipse that have limited appeal and need a highly motivated audience of early adopters and acceptors. Such techniques help evade the mass rejection that could follow mass promotion, circumvent marketing restrictions, and allow tobacco companies to benefit from health claims made by consumers. Cigarette manufacturers must be held accountable for perceived health benefits encouraged by all promotional activities including viral marketing. PMID:18332064

  3. Family function, stress, and locus of control. Relationships to glycemia in adults with diabetes mellitus.

    Science.gov (United States)

    Konen, J C; Summerson, J H; Dignan, M B

    1993-04-01

    To determine whether glycemic control in adults with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) is related to perceived family function, stress/coping, affect, and locus of control. Cross-sectional, observational study. Four hundred seven subjects from a family medicine ambulatory care unit, a tertiary pediatric diabetic unit, or a public-funded community health center, all located in Winston-Salem, NC, completed a series of psychometric instruments that included the Family APGAR (Adaptation, Partnership, Growth, Affection, and Resolve), FACES III (Family Adaptability and Cohesion Evaluation Scales) Cohesion subscale, Affect Balance Scale, Multidimensional Health Locus of Control Scales, and the Brief Encounter Psychosocial Instrument. Glycemic control was measured by fasting blood glucose levels and glycosylated hemoglobin A1C levels as well as by patients' perception of their control. Those with NIDDM had scores indicative of more external sources of control than those with IDDM. A greater proportion of adults with both subtypes of diabetes perceived their families to be disengaged than subjects from families without diabetes. In a bivariate analysis, family dysfunction correlated with lack of perceived glycemic control, while perceived stress and negative affect correlated with fasting glucose levels in those with NIDDM but not those with IDDM. Using multivariate discriminant analysis, adults with NIDDM in good glycemic control as measured by glycosylated hemoglobin levels had lower family cohesion and negative affect than those in poor control. Conversely, those with IDDM with acceptable glycosylated hemoglobin levels had higher family cohesion, less negative affect, fewer chance loci of control, but higher perception of inadequate coping than those in poor control. Knowledge of the family function, affect, locus of control, perceived stress, and coping may be useful to the family physician in the care

  4. Intact performance on an indirect measure of race bias following amygdala damage.

    Science.gov (United States)

    Phelps, Elizabeth A; Cannistraci, Christopher J; Cunningham, William A

    2003-01-01

    Recent brain imaging and lesion studies provide converging evidence for amygdala involvement in judgments of fear and trust based on facial expression [Adolphs et al., Nature 393 (1998) 470; Adolphs et al., Neuropsychologia 37 (1999) 1111; Breiter et al., Neuron 17 (1996) 875; Winston et al., Nat. Neurosci. 5 (3) (2002) 277]. Another type of social information apparent in face stimuli is social group membership. Imaging studies have reported amygdala activation to face stimuli of different racial groups [Hart et al., NeuroReport 11 (11) (2000) 2351]. In White American subjects, amygdala activation to Black versus White faces was correlated with indirect, implicit measures of racial evaluation [Phelps et al., J. Cogn. Neurosci. 12 (5) (2000) 729]. To determine if the amygdala plays a critical role in indirect social group evaluation, as suggested by the imaging results, a patient with bilateral amygdala damage and control subjects were given two measures of race bias. All subjects were female, White Americans. The Modern Racism Scale (MRS) is a direct, self-report measure of race attitudes and beliefs. The Implicit Association Test (IAT) is an indirect, automatic evaluation task. Performance on the two tasks did not differ between the patient with amygdala damage and control subjects. All subjects showed a pro-Black bias on the direct, explicit measure of race beliefs, the MRS, and a negative evaluation towards Black faces on the indirect measure of race evaluation, the IAT. These results indicate that even though amygdala activation to Black versus White faces is correlated with performance on indirect measures of race bias [Phelps et al., J. Cogn. Neurosci. 12 (5) (2000) 729], the amygdala is not critical for normal performance on the IAT.

  5. SU-F-J-53: A 3D Printed Phantom for the Use of Daily Quality Assurance Alignment Tests

    International Nuclear Information System (INIS)

    Woods, K; Ayan, A; Woollard, J; Gardner, N; Gupta, N

    2016-01-01

    Purpose: To discuss experiences and results for a 3D printed QA phantom used for daily alignment purposes for a six degrees-of-freedom (6DoF) table Methods: A 3D model was created using a fused deposition modeling (FDM) printer using free online computer-aided design (CAD) software. The model has been under use for daily QA alignment tests for a 6DoF couch. An aligned and angled baseplate were also printed in order to introduce known angles for 6DoF corrections during image-guidance. Unique registration contours were created on the faces of the phantom in order to achieve a better cone-beam computed tomography (CBCT) match using an auto-registration algorithm. A BB was also introduced at the center of the phantom in order to deliver an integrated daily Winston-Lutz (WL) test. Translational, rotational, and WL results were tabulated over one month. Results: The ’honeycomb’ structure of the print was apparent in the EPID images for the WL test, which affected the results of the analysis software. This was fixed by inserting a cube made of polyoxymethylene within the 3D phantom that encompass the BB. Auto-registration results for the three translational and three rotational from a known offset to the BB isocenter consistently fell within 1 mm and 0.2°, respectively. WL tests resulted in an average of 0.71 ± 0.14 mm. Conclusion: 3D printed models allow for accurate builds that can be customized to a variety of clinical needs. Results from translational, rotational, and WL show consistent results over a month’s time. Given its relatively cheap and streamlined workflow, 3D printing could be implemented into any clinic looking to create customized phantoms.

  6. ''Atomic Optics'': Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as ''nonimaging optics''. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  7. Implications of latest Pennsylvanian to Middle Permian paleontological and U-Pb SHRIMP data from the Tecomate Formation to re-dating tectonothermal events in the Acatlán Complex, Southern Mexico

    Science.gov (United States)

    Keppie, J. Duncan; Sandberg, Charles A.; Miller, B.V.; Sanchez-Zavala, J. L.; Nance, R.D.; Poole, Forrest G.

    2004-01-01

    Limestones in the highly deformed Tecomate Formation, uppermost unit of the Acatla??n Complex, are latest Pennsylvanian-earliest Middle Permian in age rather than Devonian, the latter based on less diagnostic fossils. Conodont collections from two marble horizons now constrain its age to range from latest Pennsylvanian to latest Early Permian or early Middle Permian. The older collection contains Gondolella sp., Neostreptognathodus sp., and Streptognathodus sp., suggesting an oldest age limit close to the Pennsylvanian-Permian time boundary. The other collection contains Sweet-ognathus subsymmetricus, a short-lived species ranging only from Kungurian (latest Leonardian) to Wordian (earliest Guadelupian: 272 ?? 4 to 264 ?? 2 Ma). A fusilinid, Parafusulina c.f. P. antimonioensis Dunbar, in a third Tecomate marble horizon is probably Wordian (early Guadelupian, early Middle Permian). Furthermore, granite pebbles in a Tecomate conglomerate have yielded ???320-264 Ma U-Pb SHRIMP ages probably derived from the ???288 Ma, arc-related Totoltepec pluton. Collectively, these data suggest a correlation with two nearby units: (1) the Missourian-Leonardian carbonate horizons separated by a Wolfcampian(?) conglomerate in the upper part of the less deformed San Salvador Patlanoaya Formation; and (2) the clastic, Westphalian-Leonardian Matzitzi Formation. This requires that deformation in the Tecomate Formation be of Early-Middle Permian age rather than Devonian. These three formations are re-interpreted as periarc deposits with deformation related to oblique subduction. The revised dating of the Tecomate Formation is consistent with new data, which indicates that the unconformity between the Tecomate and the Piaxtla Group is mid-Carboniferous and corresponds to a tectonothermal event. ?? 2004 by V. H. Winston and Son, Inc. All rights reserved.

  8. SU-E-T-54: A New Method for Optimizing Radiation Isocenter for Linac-Based SRS

    International Nuclear Information System (INIS)

    Hancock, S; Hyer, D; Nixon, E

    2015-01-01

    Purpose: To develop a new method to minimize deviation of linac x-ray beams from the centroid of the volumetric radiation isocenter for all combinations of gantry and table angle. Methods: A set of ball-bearing (Winston-Lutz) images was used to determine the gantry radiation isocenter as the midrange of deviation values. Deviations in the cross-plane direction were minimized by calibration of MLC leaf position offset, and by adjusting beam position steering for each energy. Special attention was also paid to matching the absolute position of isocenter across all energies by adjusting position steering in the gun-target axis. Displacement of table axis from the gantry isocenter, and recommended table axis adjustment for contemporary Elekta linacs, was also determined. Eight images were used to characterize the volumetric isocenter for the full range of gantry and table rotations available. Tabulation of deviation for each beam was used to test compliance with isocenter tolerance. Results: Four contemporary Elekta linacs were evaluated and the radius in the gun-target axis of the radiation isocenter was 0.5 to 0.7 mm. After beam steering adjustment, the radius in the cross-plane direction was typically 0.2 to 0.4 mm. Position matching between energies can be reduced to 0.28 mm. Maximum total deviation was 0.68 to 1.07 mm, depending primarily on the effect of systematic table axis wobble with rotation. Conclusion: This new method effectively facilitates minimization of deviation between beam center and target position. The test, which requires a few minutes to perform, can be easily incorporated into a routine machine QA program. A tighter radiation isocenter for contemporary Elekta linacs would require reducing the effect of gantry arm flex and/or table axis wobble that are the two main components of deviation from the designated isocenter point

  9. Optical Coating Performance for Heat Reflectors of the JWST-ISIM Electronic Component

    Science.gov (United States)

    Rashford, Robert A.; Perrygo, Charles M.; Garrison, Matthew B.; White, Bryant K.; Threat, Felix T.; Quijada, Manuel A.; Jeans, James W.; Huber, Frank K.; Bousquet, Robert R.; Shaw, Dave

    2011-01-01

    A document discusses a thermal radiator design consisting of lightweight composite materials and low-emittance metal coatings for use on the James Webb Space Telescope (JWST) structure. The structure will have a Thermal Subsystem unit to provide passive cooling to the Integrated Science Instrument Module (ISIM) control electronics. The ISIM, in the JWST observatory, is the platform that provides the mounting surfaces for the instrument control electronics. Dissipating the control electronic generated-heat away from JWST is of paramount importance so that the spacecraft s own heat does not interfere with the infrared-light gathering of distant cosmic sources. The need to have lateral control in the emission direction of the IEC (ISIM Electronics Compartment) radiators led to the development of a directional baffle design that uses multiple curved mirrorlike surfaces. This concept started out from the so-called Winston non-imaging optical concentrators that use opposing parabolic reflector surfaces, where each parabola has its focus at the opposite edge of the exit aperture. For this reason they are often known as compound parabolic concentrators or CPCs. This radiator system with the circular section was chosen for the IEC reflectors because it offers two advantages over other designs. The first is that the area of the reflector strips for a given radiator area is less, which results in a lower mass baffle assembly. Secondly, the fraction of energy emitted by the radiator strips and subsequently reflected by the baffle is less. These fewer reflections reduced the amount of energy that is absorbed and eventually re-emitted, typically in a direction outside the design emission range angle. A baffle frame holds the mirrors in position above a radiator panel on the IEC. Together, these will direct the majority of the heat from the IEC above the sunshield away towards empty space.

  10. Electromagnetic Field Devices and Their Effects on Nociception and Peripheral Inflammatory Pain Mechanisms.

    Science.gov (United States)

    Ross, Christina L; Teli, Thaleia; Harrison, Benjamin S

    2016-03-01

    Context • During cell-communication processes, endogenous and exogenous signaling affects normal and pathological developmental conditions. Exogenous influences, such as extra-low-frequency (ELF) electromagnetic fields (EMFs) have been shown to affect pain and inflammation by modulating G-protein coupling receptors (GPCRs), downregulating cyclooxygenase-2 (Cox-2) activity, and downregulating inflammatory modulators, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) as well as the transcription factor nuclear factor kappa B (NF-κB). EMF devices could help clinicians who seek an alternative or complementary treatment for relief of patients chronic pain and disability. Objective • The research team intended to review the literature on the effects of EMFs on inflammatory pain mechanisms. Design • We used a literature search of articles published in PubMed using the following key words: low-frequency electromagnetic field therapy, inflammatory pain markers, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), opioid receptors, G-protein coupling receptors, and enzymes. Setting • The study took place at the Wake Forest School of Medicine in Winston-Salem, NC, USA. Results • The mechanistic pathway most often considered for the biological effects of EMF is the plasma membrane, across which the EMF signal induces a voltage change. Oscillating EMF exerts forces on free ions that are present on both sides of the plasma membrane and that move across the cell surface through transmembrane proteins. The ions create a forced intracellular vibration that is responsible for phenomena such as the influx of extracellular calcium (Ca2+) and the binding affinity of calmodulin (CaM), which is the primary transduction pathway to the secondary messengers, cAMP and cGMP, which have been found to influence inflammatory pain. Conclusions • An emerging body of evidence indicates the existence of a frequency

  11. Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA

    Directory of Open Access Journals (Sweden)

    Cohen J

    2016-04-01

    Full Text Available Joshua S Cohen,1 Matthew C Miles,2 James F Donohue,3 Jill A Ohar2 1United Lung and Sleep Clinic, Saint Paul, MN, USA; 2Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3University of North Carolina Chapel Hill, Chapel Hill, NC, USA Abstract: Chronic obstructive pulmonary disease (COPD is a leading cause of morbidity, mortality, and health care expenditure worldwide. Relaxation of airway smooth muscle with inhaled bronchodilators is the cornerstone of treatment for stable COPD, with inhaled corticosteroids reserved for those with a history of exacerbations. Tiotropium has occupied center stage in COPD treatment for over 10 years and improves lung function, quality of life, exercise endurance, and reduces the risk of COPD exacerbation. Long-acting β2-agonists (LABAs improve lung function, reduce dynamic hyperinflation, increase exercise tolerance, health-related quality of life, and reduce acute exacerbation of COPD. The combination of long-acting muscarinic antagonists (LAMAs and LABAs is thought to leverage different pathways to induce bronchodilation using submaximal drug doses, increasing the benefits and minimizing receptor-specific side effects. Umeclidinium/vilanterol is the first combination of LAMA/LABA to be approved for use in stable COPD in USA and Europe. Additionally, indacaterol/glycopyrronium and aclidinium/formoterol have been approved in Europe and in numerous locations outside USA. Several other agents are in the late stages of development, most of which offer once-daily dosing. The benefits of new LAMA/LABA combinations include improved pulmonary function, dyspnea, and health-related quality of life, and in some cases, reduced exacerbations. These evolving treatments will provide new opportunities and challenges in the management of COPD. Keywords: bronchodilator, fixed-dose combination, chronic bronchitis, emphysema, COPD treatment

  12. Quantifying the gantry sag on linear accelerators and introducing an MLC-based compensation strategy

    International Nuclear Information System (INIS)

    Du Weiliang; Gao Song; Wang Xiaochun; Kudchadker, Rajat J.

    2012-01-01

    Purpose: Gantry sag is one of the well-known sources of mechanical imperfections that compromise the spatial accuracy of radiation dose delivery. The objectives of this study were to quantify the gantry sag on multiple linear accelerators (linacs), to investigate a multileaf collimator (MLC)-based strategy to compensate for gantry sag, and to verify the gantry sag and its compensation with film measurements. Methods: The authors used the Winston-Lutz method to measure gantry sag on three Varian linacs. A ball bearing phantom was imaged with megavolt radiation fields at 10 deg. gantry angle intervals. The images recorded with an electronic portal imaging device were analyzed to derive the radiation isocenter and the gantry sag, that is, the superior-inferior wobble of the radiation field center, as a function of the gantry angle. The authors then attempted to compensate for the gantry sag by applying a gantry angle-specific correction to the MLC leaf positions. The gantry sag and its compensation were independently verified using film measurements. Results: Gantry sag was reproducible over a six-month measurement period. The maximum gantry sag was found to vary from 0.7 to 1.0 mm, depending on the linac and the collimator angle. The radiation field center moved inferiorly (i.e., away from the gantry) when the gantry was rotated from 0 deg. to 180 deg. After the MLC leaf position compensation was applied at 90 deg. collimator angle, the maximum gantry sag was reduced to <0.2 mm. The film measurements at gantry angles of 0 deg. and 180 deg. verified the inferior shift of the radiation fields and the effectiveness of MLC compensation. Conclusions: The results indicate that gantry sag on a linac can be quantitatively measured using a simple phantom and an electronic portal imaging device. Reduction of gantry sag is feasible by applying a gantry angle-specific correction to MLC leaf positions at 90 deg. collimator angle.

  13. Source apportionment of sulfate and nitrate particulate matter in the Eastern United States and effectiveness of emission control programs.

    Science.gov (United States)

    Zhang, Hongliang; Hu, Jianlin; Kleeman, Michael; Ying, Qi

    2014-08-15

    Reducing population exposure to PM2.5 in the eastern US will require control of secondary sulfate and nitrate. A source-oriented Community Multi-scale Air Quality (CMAQ) model is used to determine contributions of major emission sources to nitrate and sulfate concentrations in the seven eastern US cities (New York City, Pittsburgh, Baltimore, Chicago, Detroit, St. Paul, and Winston-Salem) in January and August of 2000 and 2006. Identified major nitrate sources include on-road gasoline-powered vehicles, diesel engines, natural gas and coal combustion. From 2000 to 2006, January nitrate concentrations decreased by 25-68% for all the seven cities. On average, ~53% of this change was caused by emissions controls while 47% was caused by meteorology variations. August nitrate concentrations decreased by a maximum of 68% in New York City but Detroit experienced increasing August nitrate concentrations by up to 33%. On average, ~33% of the reduction in nitrate is offset by increases associated with meteorological conditions that favor nitrate formation. Coal combustion and natural gas are the dominant sources for sulfate in both seasons. January sulfate decrease from 2000 to 2006 in all cities by 4-58% except New York City, which increases by 13%. On average, ~93% of the reduction in sulfate was attributed to emission controls with 7% associated with changes in meteorology. August sulfate concentrations decrease by 11-44% in all cities. On average, emission controls alone between 2000 and 2006 would have caused 6% more reduction but the effectiveness of the controls was mitigated by meteorology conditions more favorable to sulfate production in 2006 vs. 2000. The results of this study suggest that regional emissions controls between 2000 and 2006 have been effective at reducing population exposure to PM2.5 in the eastern US, but yearly variations in meteorology must be carefully considered when assessing the exact magnitude of the control benefits. Copyright © 2014

  14. Rufinamide in patients with Lennox-Gastaut syndrome

    Directory of Open Access Journals (Sweden)

    Clark PO

    2016-11-01

    Full Text Available Peggy O Clark,1 Patricia A Gibson2 1Cincinnati Children’s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH, 2Epilepsy Information Service, Wake Forest University School of Medicine, Winston-Salem, NC, USA Objectives: Lennox–Gastaut syndrome (LGS is an epileptic encephalopathy with an onset at the age of ~4 years. LGS is notoriously difficult to manage, as most patients experience multiple seizures per day, despite their concomitant use of several antiepileptic drugs (AEDs. Rufinamide (BANZEL® is an AED approved by the US Food and Drug Administration for the adjunctive treatment of seizures associated with LGS in pediatric patients aged ≥1 year and in adults. The expert care of nurses knowledgeable in the treatment options for LGS is valuable to patients and caregivers. This review summarizes the existing knowledge on LGS and data from clinical and real-world studies on the use of rufinamide in patients with LGS.Methods: Recent review articles and information from the Epilepsy Foundation Website were reviewed for data on LGS treatment. Primary articles on rufinamide were also selected for review.Results and conclusion: The efficacy and safety of rufinamide have been evaluated in children and adults by using double-blind, open-label, and observational studies. In general, these studies indicate that rufinamide effectively reduces the frequency and severity of multiple seizure types associated with LGS and has tolerable side effects, the most common being vomiting and somnolence. Dosing modifications based on age, weight, and concomitant AED usage are recommended for patients using rufinamide. Keywords: Lennox–Gastaut syndrome, anticonvulsants, rufinamide

  15. GISMO: A MATLAB toolbox for seismic research, monitoring, & education

    Science.gov (United States)

    Thompson, G.; Reyes, C. G.; Kempler, L. A.

    2017-12-01

    GISMO is an open-source MATLAB toolbox which provides an object-oriented framework to build workflows and applications that read, process, visualize and write seismic waveform, catalog and instrument response data. GISMO can retrieve data from a variety of sources (e.g. FDSN web services, Earthworm/Winston servers) and data formats (SAC, Seisan, etc.). It can handle waveform data that crosses file boundaries. All this alleviates one of the most time consuming part for scientists developing their own codes. GISMO simplifies seismic data analysis by providing a common interface for your data, regardless of its source. Several common plots are built-in to GISMO, such as record section plots, spectrograms, depth-time sections, event count per unit time, energy release per unit time, etc. Other visualizations include map views and cross-sections of hypocentral data. Several common processing methods are also included, such as an extensive set of tools for correlation analysis. Support is being added to interface GISMO with ObsPy. GISMO encourages community development of an integrated set of codes and accompanying documentation, eliminating the need for seismologists to "reinvent the wheel". By sharing code the consistency and repeatability of results can be enhanced. GISMO is hosted on GitHub with documentation both within the source code and in the project wiki. GISMO has been used at the University of South Florida and University of Alaska Fairbanks in graduate-level courses including Seismic Data Analysis, Time Series Analysis and Computational Seismology. GISMO has also been tailored to interface with the common seismic monitoring software and data formats used by volcano observatories in the US and elsewhere. As an example, toolbox training was delivered to researchers at INETER (Nicaragua). Applications built on GISMO include IceWeb (e.g. web-based spectrograms), which has been used by Alaska Volcano Observatory since 1998 and became the prototype for the USGS

  16. PREFACE: 11th International Conference on Nucleus-Nucleus Collisions (NN2012)

    Science.gov (United States)

    Li, Bao-An; Natowitz, Joseph B.

    2013-03-01

    Nuclear Science and Technologies 6. Nuclear Reactions and Structure of Unstable Nuclei 7. Equation of State of Neutron-Rich Nuclear Matter, Clusters in Nuclei and Nuclear Reactions 8. Fusion and Fission 9. Nuclear Astrophysics 10. New Facilities and Detectors We would like to thank Texas A&M University and Texas A&M University-Commerce for their organizational support and for providing financial support for many students and postdocs and those who had special need. This support helped assure the success of NN2012. Special thanks also go to all members of the International Advisory Committee and the Local Organizing Committee (listed below) for their great work in advising upon, preparing and executing the NN2012 scientific program as well as the social events that all together made the NN2012 an enjoyable experience for both the participants and their companions. NN2012 International Advisory Committee N Auerbach (Israel) J Aysto (Finland) C Beck (France) S Cherubini (Italy) L Ferreira (Portugal) C Gagliardi (USA) S Gales (France) C Gale (Canada) W Gelletly (Great Britain) Paulo R S Gomes (Brazil) W Greiner (Germany) W Henning (USA) D Hinde (Australia) S Hofmann (Germany) M Hussein (Brazil) B Jacak (USA) S Kailas (India) W G Lynch (USA) Z Majka (Poland) L McLerran (USA) V Metag (Germany) K Morita (Japan) B Mueller (USA) D G Mueller (France) T Motobayashi (Japan) W Nazarewicz (USA) Y Oganessian (Russia) J Nolen (USA) E K Rehm (USA) N Rowley (France) B Sherrill (USA) J Schukraft (Switzerland) W Q Shen (China) A Stefanini (Italy) H Stoecker (Germany) A Szanto de Toledo (Brazil) U van Kolck (USA) W von Oertzen (Germany) M Wiescher (USA) N Xu (USA) N V Zamfir (Romania) W L Zhan (China) H Q Zhang (China) NN2012 Local Organizing Committee Marina Barbui Carlos Bertulani Robert Burch Jr Cheri Davis Cody Folden Kris Hagel John Hardy Bao-An Li (Co-Chair and Scientific Secretary) Joseph Natowitz (Co-Chair) Ralf Rapp Livius Trache Sherry Yennello Editors of NN2012 Proceedings Bao

  17. The effect of reminder systems on patients' adherence to treatment

    Directory of Open Access Journals (Sweden)

    Fenerty SD

    2012-02-01

    Full Text Available Sarah D Fenerty1, Cameron West1, Scott A Davis1, Sebastian G Kaplan3, Steven R Feldman1,2,41Center for Dermatology Research, Department of Dermatology, 2Department of Pathology, 3Department of Psychiatry and Behavioral Medicine, 4Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USABackground: Patient adherence is an important component of the treatment of chronic disease. An understanding of patient adherence and its modulating factors is necessary to correctly interpret treatment efficacy and barriers to therapeutic success.Purpose: This meta-analysis aims to systematically review published randomized controlled trials of reminder interventions to assist patient adherence to prescribed medications.Methods: A Medline search was performed for randomized controlled trials published between 1968 and June 2011, which studied the effect of reminder-based interventions on adherence to self-administered daily medications.Results: Eleven published randomized controlled trials were found between 1999 and 2009 which measured adherence to a daily medication in a group receiving reminder interventions compared to controls receiving no reminders. Medication adherence was measured as the number of doses taken compared to the number prescribed within a set period of time. Meta-analysis showed a statistically significant increase in adherence in groups receiving a reminder intervention compared to controls (66.61% versus 54.71%, 95% CI for mean: 0.8% to 22.4%. Self-reported and electronically monitored adherence rates did not significantly differ (68.04% versus 63.67%, P = 1.0. Eight of eleven studies showed a statistically significant increase in adherence for at least one of the reminder group arms compared to the control groups receiving no reminder intervention.Limitations: The data are limited by imperfect measures of adherence due to variability in data collection methods. It is also likely

  18. An observational feasibility study to assess the safety and effectiveness of intranasal fentanyl for radiofrequency ablations of the lumbar facet joints

    Directory of Open Access Journals (Sweden)

    Bartoszek MW

    2017-02-01

    Full Text Available Michael W Bartoszek,1 Amy McCoart,2 Kyung-soo Jason Hong,3 Chelsey Haley,2 Krista Beth Highland,4 Anthony R Plunkett1 1Department of Anesthesiology, Womack Army Medical Center, Fort Bragg, NC, 2Clinical Investigations, Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Womack Army Medical Center, Fort Bragg, NC, 3Research Department, The Center for Clinical Research, Sceptor Pain Foundation, Winston Salem, NC, 4Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Uniformed Services University, Bethesda, MD, USA Purpose: The purpose of the present observational, feasibility study is to assess the preliminary safety and effectiveness of intranasal fentanyl for lumbar facet radiofrequency ablation procedures.Patients and methods: This cohort observational study included 23 adult patients. Systolic and diastolic blood pressures, heart rate, oxygen saturation percent, Pasero Opioid-Induced Sedation Scale score, and the Defense and Veterans Pain Rating Scale pain score were assessed prior to the procedure and intranasal fentanyl (100 μg administration and every 15 minutes after administration, up to 60 minutes post administration. Follow-up of patient satisfaction with pain control and treatment was assessed 24 hours after discharge. The primary outcome was safety as evidenced by adverse events. Secondary outcomes included the above-mentioned vital signs and pain ratings.Results: No adverse events occurred in the present study and all participants maintained an acceptable level of awareness throughout the assessment period. One-way repeated measures analyses of covariance tests with Bonferroni-adjusted means indicated that oxygen saturation, blood pressure, and heart rate changed from baseline, whereas pain scores were lower at post-administration levels compared with baseline. Finally, the majority of participants reported being satisfied with pain control and treatment

  19. Characterization of new hexagonal large area Geiger Avalanche Photodiodes

    International Nuclear Information System (INIS)

    Boccone, V.; Aguilar, J.A.; Della Volpe, D.; Christov, A.; Montaruli, T.; Rameez, M.; Basili, A.

    2013-06-01

    Photomultipliers (PMTs) are the standard detector for construction of the current generation of imaging Atmospheric Cherenkov Telescopes (IACTs). Despite impressive improvements in QE and reliability in the last years, these devices suffer from the limitation of being unable to operate in the partially illuminated sky (during full or partial moon periods) as the excess light leads to a significant increase in the rate of ageing of the devices themselves and consequently limit the life of the camera. A viable alternative is the large area Geiger-mode avalanche photodiodes (G-APDs also known as Silicon Photomultipliers or SiPMs) that are commercially available from different producers in various types and dimensions. The sufficiency of the maturity of this technology for application to Cherenkov Astronomy has already been demonstrated by the FACT telescope. One of the camera designs under study for the 4 m Davies Cotton Telescope foresees the utilization of a large area G-APDs coupled to non imaging light concentrators. In collaboration with Hamamatsu and deriving from their current technology, we have designed a new hexagonal shaped large area G-APD HEX S12516 which when coupled to a Winston cone of 24 degrees cutting angle allows for a pixel angular resolution of 0.25 degrees for a f/D 1.4 telescope with a diameter of 4 m. The device, available in 2 different cell size configurations (50 μm and 100 μm), is divided into 4 different channels powered in common cathode mode. A temperature sensor was included for a better temperature evaluation in the characterization phase. The first 3 prototypes were fully characterized and the results are compared to the larger area devices commercially available such as the S10985-050C (2x2 array of 3x3 mm 2 G-APDs). The photo-detection efficiency is measured applying the Poisson statistics method using pulsed LED at 7 different wavelengths from 355 to 670 nm and for different bias over-voltages (V ov ). Optical crosstalk and

  20. SU-F-J-177: A Novel Image Analysis Technique (center Pixel Method) to Quantify End-To-End Tests

    Energy Technology Data Exchange (ETDEWEB)

    Wen, N; Chetty, I [Henry Ford Health System, Detroit, MI (United States); Snyder, K [Henry Ford Hospital System, Detroit, MI (United States); Scheib, S [Varian Medical System, Barton (Switzerland); Qin, Y; Li, H [Henry Ford Health System, Detroit, Michigan (United States)

    2016-06-15

    Purpose: To implement a novel image analysis technique, “center pixel method”, to quantify end-to-end tests accuracy of a frameless, image guided stereotactic radiosurgery system. Methods: The localization accuracy was determined by delivering radiation to an end-to-end prototype phantom. The phantom was scanned with 0.8 mm slice thickness. The treatment isocenter was placed at the center of the phantom. In the treatment room, CBCT images of the phantom (kVp=77, mAs=1022, slice thickness 1 mm) were acquired to register to the reference CT images. 6D couch correction were applied based on the registration results. Electronic Portal Imaging Device (EPID)-based Winston Lutz (WL) tests were performed to quantify the errors of the targeting accuracy of the system at 15 combinations of gantry, collimator and couch positions. The images were analyzed using two different methods. a) The classic method. The deviation was calculated by measuring the radial distance between the center of the central BB and the full width at half maximum of the radiation field. b) The center pixel method. Since the imager projection offset from the treatment isocenter was known from the IsoCal calibration, the deviation was determined between the center of the BB and the central pixel of the imager panel. Results: Using the automatic registration method to localize the phantom and the classic method of measuring the deviation of the BB center, the mean and standard deviation of the radial distance was 0.44 ± 0.25, 0.47 ± 0.26, and 0.43 ± 0.13 mm for the jaw, MLC and cone defined field sizes respectively. When the center pixel method was used, the mean and standard deviation was 0.32 ± 0.18, 0.32 ± 0.17, and 0.32 ± 0.19 mm respectively. Conclusion: Our results demonstrated that the center pixel method accurately analyzes the WL images to evaluate the targeting accuracy of the radiosurgery system. The work was supported by a Research Scholar Grant, RSG-15-137-01-CCE from the American

  1. The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis.

    Science.gov (United States)

    Casanova, Ramon; Ryali, Srikanth; Serences, John; Yang, Lucie; Kraft, Robert; Laurienti, Paul J; Maldjian, Joseph A

    2008-05-01

    In fMRI data analysis it has been shown that for a wide range of situations the hemodynamic response function (HRF) can be reasonably characterized as the impulse response function of a linear and time invariant system. An accurate and robust extraction of the HRF is essential to infer quantitative information about the relative timing of the neuronal events in different brain regions. When no assumptions are made about the HRF shape, it is most commonly estimated using time windowed averaging or a least squares estimated general linear model based on either Fourier or delta basis functions. Recently, regularization methods have been employed to increase the estimation efficiency of the HRF; typically these methods produce more accurate HRF estimates than the least squares approach [Goutte, C., Nielsen, F.A., Hansen, L.K., 2000. Modeling the Haemodynamic Response in fMRI Using Smooth FIR Filters. IEEE Trans. Med. Imag. 19(12), 1188-1201.]. Here, we use simulations to clarify the relative merit of temporal regularization based methods compared to the least squares methods with respect to the accuracy of estimating certain characteristics of the HRF such as time to peak (TTP), height (HR) and width (W) of the response. We implemented a Bayesian approach proposed by Marrelec et al. [Marrelec, G., Benali, H., Ciuciu, P., Pelegrini-Issac, M., Poline, J.-B., 2003. Robust Estimation of the Hemodynamic Response Function in Event-Related BOLD fMRI Using Basic Physiological Information. Hum. Brain Mapp. 19, 1-17., Marrelec, G., Benali, H., Ciuciu, P., Poline, J.B. Bayesian estimation of the hemodynamic of the hemodynamic response function in functional MRI. In: R. F, editor; 2001; Melville. p 229-247.] and its deterministic counterpart based on a combination of Tikhonov regularization [Tikhonov, A.N., Arsenin, V.Y., 1977. Solution of ill-posed problems. Washington DC: W.H. Winston.] and generalized cross-validation (GCV) [Wahba, G., 1990. Spline Models for Observational Data

  2. Advances in the management of erythropoietic protoporphyria – role of afamelanotide

    Directory of Open Access Journals (Sweden)

    Lane AM

    2016-12-01

    Full Text Available Ashley M Lane,1 Jerome T McKay,2 Herbert L Bonkovsky1 1Department of Internal Medicine, Section on Gastroenterology; 2Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract: Erythropoietic protoporphyria (EPP and the phenotypically similar disease X-linked protoporphyria (XLPP are inherited cutaneous porphyrias characterized clinically by acute non-blistering photosensitivity, intolerance to sunlight, and significantly reduced quality of life. They are due to marked overproduction of protoporphyrin (PP chiefly by erythroblasts and reticulocytes. In EPP, the underlying genetic defect is in the ferrochelatase gene, which encodes the final enzyme in the heme synthetic pathway. In XLPP, the genetic defect is a gain-of-function mutation, usually a four-base deletion, in the gene that encodes the enzyme 5-aminolevulinic acid synthase-2, the first and rate-controlling enzyme of heme synthesis in developing red blood cells. The excess PP causes acute and painful photosensitivity, being activated by light in the long ultraviolet to blue spectrum (380–420 nm, the Soret band. Although several treatments have been proposed, presently no very effective treatment exists for EPP or XLPP. Afamelanotide (Scenesse® is a first-in-class synthetic analog of α-melanocyte stimulating hormone. Afamelanotide mimics the naturally occurring hormone to increase skin pigmentation by increasing melanin production in melanocytes, resulting in increased sunlight tolerance in those with EPP/XLPP. Afamelanotide is currently approved for use in the European Union and Switzerland, and it is under review in the United States by the Food and Drug Administration for use in patients with EPP/XLPP. This paper provides a review of the clinical characteristics and current therapies for EPP/XLPP. We discuss the pharmacology, clinical efficacy, safety, and tolerability of afamelanotide and summarize the results of several

  3. SU-E-T-406: Use of TrueBeam Developer Mode and API to Increase the Efficiency and Accuracy of Commissioning Measurements for the Varian EDGE Stereotactic Linac

    International Nuclear Information System (INIS)

    Gardner, S; Gulam, M; Song, K; Li, H; Huang, Y; Zhao, B; Qin, Y; Snyder, K; Kim, J; Gordon, J; Chetty, I; Wen, N

    2014-01-01

    Purpose: The Varian EDGE machine is a new stereotactic platform, combining Calypso and VisionRT localization systems with a stereotactic linac. The system includes TrueBeam DeveloperMode, making possible the use of XML-scripting for automation of linac-related tasks. This study details the use of DeveloperMode to automate commissioning tasks for Varian EDGE, thereby improving efficiency and measurement consistency. Methods: XML-scripting was used for various commissioning tasks,including couch model verification,beam-scanning,and isocenter verification. For couch measurements, point measurements were acquired for several field sizes (2×2,4×4,10×10cm 2 ) at 42 gantry angles for two couch-models. Measurements were acquired with variations in couch position(rails in/out,couch shifted in each of motion axes) compared to treatment planning system(TPS)-calculated values,which were logged automatically through advanced planning interface(API) scripting functionality. For beam scanning, XML-scripts were used to create custom MLC-apertures. For isocenter verification, XML-scripts were used to automate various Winston-Lutz-type tests. Results: For couch measurements, the time required for each set of angles was approximately 9 minutes. Without scripting, each set required approximately 12 minutes. Automated measurements required only one physicist, while manual measurements required at least two physicists to handle linac positions/beams and data recording. MLC apertures were generated outside of the TPS,and with the .xml file format, double-checking without use of TPS/operator console was possible. Similar time efficiency gains were found for isocenter verification measurements Conclusion: The use of XML scripting in TrueBeam DeveloperMode allows for efficient and accurate data acquisition during commissioning. The efficiency improvement is most pronounced for iterative measurements, exemplified by the time savings for couch modeling measurements(approximately 10 hours

  4. Design and Implementation of a Novel Web-Based E-Learning Tool for Education of Health Professionals on the Antibiotic Vancomycin.

    Science.gov (United States)

    Bond, Stuart Evan; Crowther, Shelley P; Adhikari, Suman; Chubaty, Adriana J; Yu, Ping; Borchard, Jay P; Boutlis, Craig Steven; Yeo, Wilfred Winston; Miyakis, Spiros

    2017-03-30

    gaps were identified that allowed for targeting of future education strategies. The VI provides an innovative model for delivering Web-based education to busy health professionals in different locations. ©Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.03.2017.

  5. Cardioprotective medication use and risk factor control among US adults with unrecognized myocardial infarction: the REasons for Geographic And Racial Differences in Stroke (REGARDS study

    Directory of Open Access Journals (Sweden)

    Levitan EB

    2013-02-01

    Full Text Available Emily B Levitan,1 Christopher Gamboa,1 Monika M Safford,2 Dana V Rizk,3 Todd M Brown,4 Elsayed Z Soliman,5 Paul Muntner11Department of Epidemiology, 2Division of Preventive Medicine, 3Division of Nephrology, 4Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA; 5Epidemiological Cardiology Research Center, Wake Forest University School of Medicine, Winston Salem, NC, USABackground: Individuals with unrecognized myocardial infarction (UMI have similar risks for cardiovascular events and mortality as those with recognized myocardial infarction (RMI. The prevalence of cardioprotective medication use and blood pressure and low-density lipoprotein cholesterol control among individuals with UMI is unknown.Methods: Participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS study who were recruited between May 2004 and October 2007 received baseline twelve-lead electrocardiograms (n = 21,036. Myocardial infarction (MI status was characterized as no MI, UMI (electrocardiogram abnormalities consistent with MI without self-reported history; n = 949; 4.5%, and RMI (self-reported history of MI; n = 1574; 7.5%.Results: For participants with no MI, UMI, and RMI, prevalence of use was 38.4%, 44.4%, and 75.7% for aspirin; 18.0%, 25.8%, and 57.2% for beta blockers; 31.7%, 38.7%, and 55.0% for angiotensin converting enzyme inhibitors or angiotensin receptor blockers; and 28.1%, 33.9%, and 64.1% for statins, respectively. Participants with RMI were 35% more likely to have low-density lipoprotein cholesterol < 100 mg/dL than participants with UMI (prevalence ratio = 1.35, 95% confidence interval 1.19–1.52. Blood pressure control (<140/90 mmHg was similar between RMI and UMI groups (prevalence ratio = 1.03, 95% confidence interval 0.93–1.13.Conclusion: Although participants with UMI were somewhat more likely to use cardioprotective medications than those with no MI, they were less likely to use

  6. Depression and frailty in later life: a systematic review

    Directory of Open Access Journals (Sweden)

    Vaughan L

    2015-12-01

    Full Text Available Leslie Vaughan,1 Akeesha L Corbin,1 Joseph S Goveas2 1Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, MI, USA Abstract: Frailty and depression are important issues affecting older adults. Depressive syndrome may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews on the topic include studies with wide methodological variation. This review examined the published literature on cross-sectional and longitudinal associations between frailty and depressive symptomatology with either syndrome as the outcome, moderators of this relationship, construct overlap, and related medical and behavioral interventions. Prevalence of both was reported. A systematic review of studies published from 2000 to 2015 was conducted in PubMed, the Cochrane Database of Systematic Reviews, and PsychInfo. Key search terms were “frailty”, “frail”, “frail elderly”, “depressive”, “depressive disorder”, and “depression”. Participants of included studies were ≥55 years old and community dwelling. Included studies used an explicit biological definition of frailty based on Fried et al’s criteria and a screening measure to identify depressive symptomatology. Fourteen studies met the inclusion/exclusion criteria. The prevalence of depressive symptomatology, frailty, or their co-occurrence was greater than 10% in older adults ≥55 years old, and these rates varied widely, but less in large epidemiological studies of incident frailty. The prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive. The presence of comorbidities that interact with depressive symptomatology increased incident frailty risk. Measurement variability of depressive symptomatology and inclusion of older adults

  7. Relative cost-effectiveness of using a liquid human milk fortifier in preterm infants in the US

    Directory of Open Access Journals (Sweden)

    Guest JF

    2017-01-01

    Full Text Available Julian F Guest,1,2 Fernando Moya,3 Paula M Sisk,4 Mark L Hudak,5 Devon Kuehn6 1Catalyst Health Economics Consultants, Northwood, Middlesex, UK; 2Faculty of Life Sciences and Medicine, King’s College, London, UK; 3Coastal Carolina Neonatology, Wilmington, NC, USA; 4Novant Health Forsyth Medical Center, Winston Salem, NC, USA; 5Department of Pediatrics, University of Florida College of Medicine, Jacksonville, FL, USA; 6Department of Pediatrics, East Carolina University, Greenville, NC, USA Objective: To estimate the cost-effectiveness of using a liquid human milk fortifier (LHMF compared to a powdered human milk fortifier (PHMF in preterm infants in the US from the perspective of third-party payers and parents.Methods: This was a decision modelling study using patient data obtained from a randomized controlled trial comparing a LHMF with a PHMF in preterm infants, supplemented with additional data obtained by performing a chart review among 79% of the trial patients. The model estimated the cost-effectiveness of LHMF versus PHMF in US$ at 2014/2015 prices.Results: More infants in the LHMF group were discharged home (92% versus 89% and more infants in the PHMF group were transferred to another unit (9% versus 5%. Gestational age was an independent predictor for being discharged home (odds ratio of 2.18; p=0.006 for each week of gestational age. Mean length of neonatal intensive care unit (NICU stay was 1 day less in the LHMF than the PHMF group (62.3 versus 63.4 days, but mean length of NICU stay among infants who developed NEC or sepsis was 79.3 days and 61.2 days in the PHMF and LHMF groups, respectively. Total management cost up to discharge was $10,497 per infant less in the LHMF group than the PHMF group ($240,928 versus $251,425.Conclusion: Using LHMF instead of PHMF in preterm infants enabled resources to be freed-up for alternative use within the system. There is no health economic reason why LHMF should not be used in preference to PHMF

  8. Barriers and facilitators associated with colonoscopy completion in individuals with multiple chronic conditions: a qualitative study

    Directory of Open Access Journals (Sweden)

    Sultan S

    2017-05-01

    Full Text Available Shahnaz Sultan,1–4 Melissa R Partin,1,2 Phalgoon Shah,5 Jennifer LeLaurin,4 Ivette Magaly Freytes,4 Chandylen L Nightingale,6 Susan F Fesperman,4 Barbara A Curbow,7 Rebecca J Beyth3,4,8 1Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Health Care System, 2Department of Medicine, University of Minnesota, Minneapolis, MN, 3Department of Medicine, University of Florida College of Medicine, Gainesville, FL, 4Center of Innovation on Disability and Rehabilitation Research, North Florida/South Georgia Veterans Health System, Gainesville, FL, 5Department of Medicine, Tripler Army Medical Center, Honolulu, HI, 6Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem NC, 7Department of Community and Behavioral Health, University of Maryland, College Park, MD, 8Geriatric Research, Education and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA Background: A recommendation to undergo a colonoscopy, an invasive procedure that requires commitment and motivation, planning (scheduling and finding a driver and preparation (diet restriction and laxative consumption, may be uniquely challenging for individuals with multiple chronic conditions (MCCs. This qualitative study aimed to describe the barriers and facilitators to colonoscopy experienced by such patients.Materials and methods: Semistructured focus groups were conducted with male Veterans who were scheduled for outpatient colonoscopy and either failed to complete the procedure or completed the examination. Focus group recordings were transcribed and analyzed by an inductive grounded approach using constant comparative analysis.Results: Forty-four individuals aged 51–83 years participated in this study (23 adherent and 21 nonadherent. Participants had an average of 7.4 chronic conditions (range 2–14. The five most common chronic conditions were hypertension (75%, hyperlipidemia (75

  9. Building groundwater modeling capacity in Mongolia

    Science.gov (United States)

    Valder, Joshua F.; Carter, Janet M.; Anderson, Mark T.; Davis, Kyle W.; Haynes, Michelle A.; Dorjsuren Dechinlhundev,

    2016-06-16

    Ulaanbaatar, the capital city of Mongolia (fig. 1), is dependent on groundwater for its municipal and industrial water supply. The population of Mongolia is about 3 million people, with about one-half the population residing in or near Ulaanbaatar (World Population Review, 2016). Groundwater is drawn from a network of shallow wells in an alluvial aquifer along the Tuul River. Evidence indicates that current water use may not be sustainable from existing water sources, especially when factoring the projected water demand from a rapidly growing urban population (Ministry of Environment and Green Development, 2013). In response, the Government of Mongolia Ministry of Environment, Green Development, and Tourism (MEGDT) and the Freshwater Institute, Mongolia, requested technical assistance on groundwater modeling through the U.S. Army Corps of Engineers (USACE) to the U.S. Geological Survey (USGS). Scientists from the USGS and USACE provided two workshops in 2015 to Mongolian hydrology experts on basic principles of groundwater modeling using the USGS groundwater modeling program MODFLOW-2005 (Harbaugh, 2005). The purpose of the workshops was to bring together representatives from the Government of Mongolia, local universities, technical experts, and other key stakeholders to build in-country capacity in hydrogeology and groundwater modeling.A preliminary steady-state groundwater-flow model was developed as part of the workshops to demonstrate groundwater modeling techniques to simulate groundwater conditions in alluvial deposits along the Tuul River in the vicinity of Ulaanbaatar. ModelMuse (Winston, 2009) was used as the graphical user interface for MODFLOW for training purposes during the workshops. Basic and advanced groundwater modeling concepts included in the workshops were groundwater principles; estimating hydraulic properties; developing model grids, data sets, and MODFLOW input files; and viewing and evaluating MODFLOW output files. A key to success was

  10. Verification of the linac isocenter for stereotactic radiosurgery using cine-EPID imaging and arc delivery

    International Nuclear Information System (INIS)

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O' Connor, Daryl J.; Greer, Peter B.

    2011-01-01

    Purpose:Verification of the mechanical isocenter position is required as part of comprehensive quality assurance programs for stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments. Several techniques have been proposed for this purpose but each of them has certain drawbacks. In this paper, a new efficient and more comprehensive method using cine-EPID images has been introduced for automatic verification of the isocenter with sufficient accuracy for stereotactic applications. Methods: Using a circular collimator fixed to the gantry head to define the field, EPID images of a Winston-Lutz phantom were acquired in cine-imaging mode during 360 deg. gantry rotations. A robust matlab code was developed to analyze the data by finding the center of the field and the center of the ball bearing shadow in each image with sub-pixel accuracy. The distance between these two centers was determined for every image. The method was evaluated by comparison to results of a mechanical pointer and also by detection of a manual shift applied to the phantom position. The repeatability and reproducibility of the method were tested and it was also applied to detect couch and collimator wobble during rotation. Results:The accuracy of the algorithm was 0.03 ± 0.02 mm. The repeatability was less than 3 μm and the reproducibility was less than 86 μm. The time elapsed for the analysis of more than 100 cine images of Varian aS1000 and aS500 EPIDs were ∼65 and 20 s, respectively. Processing of images taken in integrated mode took 0.1 s. The output of the analysis software is printable and shows the isocenter shifts as a function of angle in both in-plane and cross-plane directions. It gives warning messages where the shifts exceed the criteria for SRS/SRT and provides useful data for the necessary adjustments in the system including bearing system and/or room lasers. Conclusions: The comprehensive method introduced in this study uses cine-images, is highly accurate, fast, and independent

  11. An Investigation of Faculty Relationships as a Source of Motivation for STEM Undergraduates at a Historically Black University

    Science.gov (United States)

    Mitchell, Aquila

    2011-12-01

    The expansion of STEM education and career opportunities among underrepresented populations is a national priority. Therefore, more research is needed that examines the institutional, instructional and individual factors related to African American students' success in these fields. This dissertation study was drawn from a larger mixed-methods longitudinal study (Freeman and Winston, 2007). It utilized a concurrent embedded design of mixed methods (Creswell, 2009), to investigate faculty relationships as a source of motivation for STEM undergraduates at a HBCU. Bandura's (1986) social cognitive theory was the theoretical basis for this study. The following research questions were examined: (a) What is the nature of student-faculty relationships among STEM undergraduates attending an HBCU; (b) How does the nature of faculty student relationships vary by gender and STEM major; (c) How do student-faculty relationships influence students' persistence in STEM, self-concept of ability in mathematics and in science and grade point average; and (d) Does the influence of student-faculty relationships on self-concept of ability in mathematics and in science and grade point average vary by gender and STEM major? Freshman college students (N=167) who had a declared major in STEM fall 2009 were participants in this study. Students were predominately Black/African American (82%) and predominately female (71%). The Student-Professor Interaction Scale (SPIS) was used to measure various dimensions of student-faculty interactions (Cokley, Komarraju, Rosales, et al., 2006). The Experiences with Faculty Scale (Pace & Kuh, 1998) was used to measure the frequency of student's experiences with faculty. Self-Concept of Ability Scales in Mathematics and in Science (Marsh, 1999) was used to measure students' global perception of their abilities. An open-ended question was designed to expand and provide breadth to the quantitative results. Findings indicated that student

  12. Characteristics and performance of the first commercial multileaf collimator for a robotic radiosurgery system.

    Science.gov (United States)

    Fürweger, Christoph; Prins, Paulette; Coskan, Harun; Heijmen, Ben J M

    2016-05-01

    The "InCise™ multileaf-collimator (MLC)" is the first commercial MLC to be mounted on a robotic SRS/SBRT platform (CyberKnife). The authors assessed characteristics and performance of this novel device in a preclinical five months test period. Commissioning beam data were acquired with unshielded diodes. EBT3 radiochromic films were employed for measurement of transmission, leaf/bank position accuracy (garden fence) before and after exercising the MLC, for end-to-end testing and further characterization of the beam. The robot workspace with MLC was assessed analytically by transformation to an Euler geometry ("plane," "gantry," and "collimator" angles) and by measuring pointing accuracy at each node. Stability over time was evaluated in picket fence and adapted Winston-Lutz tests (AQA). Beam penumbrae (80%-20%, with 100% = 2 × dose at inflection point for field sizes ≥ 50 × 50 mm(2)) were 2.2-3.7 mm for square fields in reference condition (source-axis-distance 800 mm, depth 15 mm) and depended on field size and off-axis position. Transmission and leakage did not exceed 0.5%. Accessible clinical workspace with MLC covered non-coplanar gantry angles of [-113°; +112°] and collimator angles of [-100°; +107°], with an average robot pointing accuracy of 0.12 ± 0.09 mm. For vertical beams, garden fence tests exhibited an average leaf positioning error of ≤0.2 mm, which increased by 0.25 and 0.30 mm (banks X1 and X2) with leaves traveling parallel to gravity. After execution of a leaf motion stress routine, garden fence tests showed slightly increased jaggedness and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.38 ± 0.05 mm in nine end-to-end tests. Picket fence and AQA tests displayed stable results over the test period. The InCise™ MLC for CyberKnife showed high accuracy and adequate characteristics for SRS/SBRT applications. MLC performance after exercise demands specific quality assurance measures.

  13. Long-term safety and analgesic efficacy of buprenorphine buccal film in patients with moderate-to-severe chronic pain requiring around-the-clock opioids

    Directory of Open Access Journals (Sweden)

    Hale M

    2017-01-01

    Full Text Available Martin Hale,1 Veronica Urdaneta,2 M Todd Kirby,3 Qinfang Xiang,4 Richard Rauck5 1Gold Coast Research, LLC, Plantation, FL, USA; 2Pharmacovigilance and Risk Management, 3Clinical Development, 4Biometrics, Endo Pharmaceuticals Inc., Malvern, PA, USA; 5Carolinas Pain Institute, Wake Forest Baptist Health, Winston Salem, NC, USA Background: This open-label, single-arm study was conducted to evaluate the long-term safety and efficacy of a novel buprenorphine formulation, buprenorphine buccal film, in the treatment of moderate-to-severe chronic pain requiring around-the-clock opioids.Methods: The primary purpose of this study was to evaluate the long-term safety and tolerability of buprenorphine buccal film. Five hundred and six patients who completed previous studies with buprenorphine buccal film (n=445; rollover patients or were recruited de novo for this study (n=61 were enrolled in this study. All patients underwent a dose titration period of ≤6 weeks, during which doses of buprenorphine buccal film were adjusted to a maximum 900 µg every 12 hours, depending on tolerability and the need for rescue medication. An optimal dose was defined as the dose that the patient found satisfactory for both pain relief and tolerability, without the need for rescue medication or with ≤2 tablets of rescue medication per day. Once the optimal dose was reached, treatment was continued for ≤48 weeks. Pain intensity was measured throughout the study using a 0–10 numerical rating scale.Results: Of 435 patients achieving an optimal dose of buprenorphine buccal film who commenced long-term treatment, 158 (36.3% completed 48 weeks of treatment. Treatment-related adverse events occurred in 116 patients (22.9% during the titration phase and 61 patients (14.0% during the long-term treatment phase, and adverse events leading to discontinuation of treatment occurred in 14 (2.8% and 14 (3.2% patients, respectively. The most common adverse events were those typically

  14. Pressure calibrants in the hydrothermal diamond-anvil cell

    Science.gov (United States)

    Chou, I.-Ming

    2007-01-01

    ,c). Phase transitions for these three pressure calibrants are easy to detect visually, and their P-T phase boundaries have negative slopes and intersect isochors of most of the geologic fluids at high angles and, therefore, are easy to apply. Copyright ?? 2007 by V. H. Winston & Son, Inc. All rights reserved.

  15. Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells

    Directory of Open Access Journals (Sweden)

    Kang FC

    2018-03-01

    Full Text Available Fu-Chi Kang,1,* Shu-Chun Wang,2,* Ming-Min Chang,2 Bo-Syong Pan,3 Kar-Lok Wong,4 Ka-Shun Cheng,4,5 Edmund Cheung So,4,6 Bu-Miin Huang2,7 1Department of Anesthesia, Chi Mei Medical Center, Chiali, Tainan, Taiwan, Republic of China; 2Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; 3Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA; 4Department of Anesthesia, China Medical University, Taichung, Taiwan, Republic of China; 5Department of Anesthesiology, The Qingdao University Yuhuangding Hospital, Yantai, Shandong, China; 6Department of Anesthesia, An Nan Hospital, China Medical University, Tainan, Taiwan, Republic of China; 7Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China *These authors contributed equally to this work Background: Midazolam (MDZ has powerful hypnosis, amnesia, anti-anxiety and anticonvulsant effects. Studies have shown that prenatally developmental toxicity of diazepam can be observed in many organs/tissues. However, it remains elusive in male reproductive system.Materials and methods: TM3 mouse Leydig progenitor cell line was used to determine whether MDZ has any unfavorable effects.Results: Midazolam significantly decreased cell viability in dose- and time-dependent manners in TM3 cells. In flow cytometry analysis, midazolam significantly increased subG1 phase cell numbers, and annexin V/PI double staining assay further confirmed that MDZ induced apoptosis in TM3 cells. Moreover, MDZ significantly induced the expression of caspase-8 and -3 proteins and the phosphorylation of JNK, ERK1/2 and p38. Besides, MDZ didn’t activate Akt pathway in TM3 cells. Furthermore, the expressions of p-EIF2α, ATF4, ATF3 and CHOP were induced by midazolam, suggesting that midazolam could induce apoptosis through endoplasmic reticulum (ER stress

  16. SU-F-BRE-09: Linac Isocenter Quality Assurance: A Stereotactic Approach

    International Nuclear Information System (INIS)

    McCabe, B; Li, J

    2014-01-01

    Purpose: A quantitative method was designed to independently determine the couch/collimator/gantry isocenters, as well as the overall LINAC mechanical isocenter in 3D. Methods: Performed on both a Varian TrueBeam™ STx and Trilogy with the gold standard front pointer positioned at 100 cm SAD, and a Radionics XKnife™ (RX) attached to the couch. At gantry and couch 0°, the RX laser alignment attachment (RXLAA) was centered to the front pointer using the micrometers (0.1-mm precision) on the RX. The 3D coordinates of the micrometers were recorded. The collimator was rotated to 90° and 270°. At each collimator rotation, the RXLAA was re-centered to the front pointer and the micrometer coordinates recorded. At collimator and gantry 0°, the process was repeated for couch angles 0°/90°/270°. Finally, at collimator and couch 0°, the steps were repeated for gantry rotations 0°/90°/180°/270°. The centers/radii of the smallest bounding spheres for the collimator, couch and gantry walkout were calculated (using MatLab™). The smallest bounding sphere containing the collimator, couch and gantry walkout spheres was then calculated. The center of this all-encompassing sphere is the overall mechanical isocenter of the LINAC. This position was dialed in on the RX. LINAC mechanical and radiation isocenter coincidence was determined by performing Winston- Lutz test at four cardinal gantry angles. Results: TrueBeam and Trilogy mechanical isocenters had overall walkout radii of 0.8 mm and 1.5 mm, respectively. For the TrueBeam and Trilogy 6-MV beams, the radii of radiation isocenter were 0.3 mm and 0.4 mm, respectively, with distances between LINAC mechanical and radiation isocenters of 0.5 mm and 0.9 mm, respectively. Conclusion: This efficient and simple method allows for an independent and reliable quantitative assessment of LINAC isocenter in 3D with equipment typically available in a radiation oncology clinic. It can easily be performed for LINAC commissioning and

  17. TH-AB-201-07: Filmless Treatment Localization QA for the CyberKnife System

    International Nuclear Information System (INIS)

    Gersh, J; Noll, M

    2016-01-01

    Purpose: Accuray recommends daily evaluation of the treatment localization and delivery systems (TLS/TDS) of the CyberKnife. The vendor-provided solution is a Winston-Lutz-type test that evaluates film shadows from an orthogonal beam pair (known as AQA). Since film-based techniques are inherently inefficient and potentially inconsistent and uncertain, this study explores a method which provides a comparable test with greater efficiency, consistency, and certainty. This test uses the QAStereoChecker (QASC, Standard Imaging, Inc., Middleton, WI), a high-resolution flat-panel detector with coupled fiducial markers for automated alignment. Fiducial tracking is used to achieve high translational and rotational position accuracy. Methods: A plan is generated delivering five circular beams, with varying orientation and angular incidence. Several numeric quantities are calculated for each beam: eccentricity, centroid location, area, major-axis length, minor-axis length, and orientation angle. Baseline values were acquired and repeatability of baselines analyzed. Next, errors were induced in the path calibration of the CK, and the test repeated. A correlative study was performed between the induced errors and quantities measured using the QASC. Based on vendor recommendations, this test should be able to detect a TLS/TDS offset of 0.5mm. Results: Centroid shifts correlated well with induced plane-perpendicular offsets (p < 0.01). Induced vertical shifts correlated best with the absolute average deviation of eccentricities (p < 0.05). The values of these metrics which correlated with the threshold of 0.5mm induced deviation were used as individual pass/fail criteria. These were then used to evaluate induced offsets which shifted the CK in all axes (a clinically-realistic offset), with a total offset of 0.5mm. This test provided high and specificity and sensitivity. Conclusion: From setup to analysis, this filmless TLS/TDS test requires 4 minutes, as opposed to 15–20

  18. Multi-stage origin of the Coast Range ophiolite, California: Implications for the life cycle of supra-subduction zone ophiolites

    Science.gov (United States)

    Shervais, J.W.; Kimbrough, D.L.; Renne, P.; Hanan, B.B.; Murchey, B.; Snow, C.A.; Zoglman, Schuman M.M.; Beaman, J.

    2004-01-01

    dikes) to represent the collision of an active spreading ridge. Subsequent reorganization of relative plate motions led to sinistral transpression, along with renewed subduction and accretion of the Franciscan Complex. The latter event resulted in uplift and exhumation of the ophiolite by the process of accretionary uplift. ?? 2004 by V. H. Winston and Son, Inc. All rights reserved.

  19. Evaluating the Effect of a Web-Based E-Learning Tool for Health Professional Education on Clinical Vancomycin Use: Comparative Study.

    Science.gov (United States)

    Bond, Stuart Evan; Crowther, Shelley P; Adhikari, Suman; Chubaty, Adriana J; Yu, Ping; Borchard, Jay P; Boutlis, Craig Steven; Yeo, Wilfred Winston; Miyakis, Spiros

    2018-02-26

    rates limited conclusions regarding the tool's effectiveness. Improvements to design and evaluation methodology may increase the likelihood of a demonstrable effect from e-learning tools in the future. ©Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis. Originally published in JMIR Medical Education (http://mededu.jmir.org), 26.02.2018.

  20. PREFACE: XXXIII Symposium on Nuclear Physics

    Science.gov (United States)

    Barrón-Palos, Libertad; Bijker, Roelof; Fossion, Ruben; Lizcano, David

    2010-04-01

    physics, ranging from the traditional fields of nuclear structure and reactions to radioactive beams, nuclear astrophysics, hadronic physics, fundamental symmetries, ultrarelativistic heavy ions, cosmic rays and quantum chaos. The high quality of the talks, the prestige of the speakers and the broad spectrum of subjects covered in the meeting, shows that nuclear physics is a very active area at the frontier of scientific research which establishes bridges between many different disciplines. One of the exciting new areas in nuclear physics is that of radioactive beams. It provides a powerful tool not only to study exotic nuclei close to the proton and neutron drip lines to obtain important information about the nature of the nucleon-nucleon interaction in stable and unstable nuclei, but also to address questions of fundamental importance in nuclear astrophysics as well as in various applications like mass spectroscopy, the production of radioactive isotopes and medical applications (Galindo-Uribarri). There was a presentation on the FRIB project which is currently under construction in the USA and its relevance for nuclear astrophysics and the limits of stability (Sherrill and Schatz) In the session on nuclear structure, there were several talks on the nucleon-nucleon interaction in nuclei close to the proton and neutron drip lines, like neutron-proton pairing in nuclei with an equal number of protons and neutrons (Pittel), and studies of stable and unstable neutron-rich nuclei near the closed shells N = 82 and N = 50 using (d, p) transfer reactions and Coulomb excitation by means of radioactive beams (Cizewski and Padilla-Rodal). There were several talks on the importance of reaction rates for the excitation of spin-isospin resonances (Sakai), massive star evolution (Klapp) and nuclear synthesis and stellar evolution (Rolfs). In another presentation, the importance of rare isotopes for astrophysical processes was highlighted (Schatz). In addition, there were discussions

  1. The most important single factor influencing learning is what the learner already knows - What do the learner know about clouds, precipitation, wind and greenhouse effect; a short review of research from 1883 to 2009

    Science.gov (United States)

    Hansen, P. J. K.

    2009-09-01

    Stanisstreet, staring up in 1992 and writing more than a dozen articles and book chapters - often together with researchers from other countries. Common features of Hansen, Boyes and Stanisstreet and many other researchers' discoveries up to present, are that students on all levels still exchange or confuse the greenhouse effect with the effects of the ozone layer, and many thinks that the greenhouse effect is not necessary for life on the Erath. The greenhouse effect and related topics came into secondary curriculum during the 1990-ies in many countries. The presentation will discuss some ideas of how to teach him accordingly at secondary education. Ausubel, D. P. 1968: Educational Psychology: A Cognitive View. Holt, Rinehart and Winston Inc. New York. Ausubel, D. P., J. D. Novak og H. Hanesian 1978: Educational Psychology. A Cognitive View. Second Edition. Holt, Rinehart and Winston, New York, Chicago, San Francisco, Dallas, Montreal, Toronto, London, Sydney. Hall, G. S. 1883: The Contents of Children's Minds. Princeton Review. Vol.XI, 1883, s.249-272. Piaget, J. 1930: The Child's Conception of Physical Causality. Kegan Paul, Trench, Trubner & Co.LTD, London. New York: Harcourt Brace & Company. Oversettelse av La causalité physique chez l'enfant fra 1927. Piaget, J. 1977: The Child's Conception of the World. 2. Edition. Paladin, London. Oversettelse av La représentation du monde chez l'enfant fra 1926. Boyes, E. og M. Stanisstreet 1992: Students' Perceptions of Global Warming. International Journal of Environmental Studies. 1992, Vol.42, s.287-300. Hansen, P. J. K. 1989: Spørsmål om vær og meteorologi til elever i 9.klasse i Oslo-området i 1989. Oslo lærerhøgskoles skriftserie. Hefte nr.2/92, Oslo (Nå Høgskolen i Oslo, Avdeling for lærerutdanning). 1.opplag 1989, Oslo lærerhøgskole, Oslo. Hansen, P. J. K. 2009: Knowledge about the greenhouse effect and the effects of the ozone layer among Norwegian pupils finishing compulsory education in 1989, 1993 and 2005

  2. A long-term, open-label safety study of single-entity hydrocodone bitartrate extended release for the treatment of moderate to severe chronic pain

    Directory of Open Access Journals (Sweden)

    Nalamachu S

    2014-11-01

    Full Text Available Srinivas Nalamachu,1,2 Richard L Rauck,3 Martin E Hale,4 Orlando G Florete Jr,5 Cynthia Y Robinson,6 Stephen J Farr,6 1International Clinical Research Institute, Overland Park, KS, USA; 2Kansas University Medical Center, Kansas City, KS, USA; 3Carolinas Pain Institute, Center for Clinical Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 4Gold Coast Research, LLC, Weston, FL, USA; 5Institute of Pain Management, Jacksonville, FL, USA; 6Zogenix, Inc., Emeryville, CA, USA Objective: To evaluate the long-term safety, tolerability, and effectiveness of single-entity extended-release hydrocodone in opioid-experienced subjects with moderate to severe chronic pain not receiving adequate pain relief or experiencing intolerable side effects from their current opioid. Methods: This multicenter, open-label study started with a conversion/titration phase (≤6 weeks where subjects (n=638 were converted to individualized doses (range 20–300 mg of extended-release hydrocodone dosed every 12 hours, followed by a 48-week maintenance phase (n=424. The primary objective (safety and tolerability and the secondary objective (long-term efficacy as measured by change in average pain score; 0= no pain, 10= worst imaginable pain were monitored throughout the study. Results: Subjects were treated for a range of chronic pain etiologies, including osteoarthritis, low back pain, and neuropathic and musculoskeletal conditions. The mean hydrocodone equivalent dose at screening was 68.9±62.2 mg/day and increased to 139.5±81.7 mg/day at the start of the maintenance phase. Unlimited dose adjustments were permitted at the investigator's discretion during the maintenance phase, reflecting typical clinical practice. No unexpected safety issues were reported. Common adverse events during the conversion/titration and maintenance phases, respectively, were constipation (11.3% and 12.5%, nausea (10.7% and 9.9%, vomiting (4.1% and 9.7%, and somnolence (7

  3. The Irpinia Seismic Network (ISNet): hardware and data management

    Science.gov (United States)

    Iannaccone, G.

    2009-04-01

    The Irpinia Seismic Network, operating in southern Italy, is primarily aimed at providing an alert for moderate to large earthquakes in selected target sites in the Campania Region, and it also provides data for rapid computation of regional ground-shaking maps. ISNet is deployed over the active seismic faults system of Irpinia, southern Italy. It features 28 seismic stations and 5 data processing sites (local control centers - LCC). All stations are equipped with a strong-motion accelerometer and a three component velocimeter, with a one second natural period, for a high dynamic recording range. Five stations host broadband sensors, for recording regional and teleseismic events. The recorded seismic data are sent from each station to the nearby LCC, through a Wi-Fi directional antenna, in SeedLink format. Each LCC runs: the SeisComP software, to relay the data to outside SeedLink clients; the Earthworm system, for real-time processing (e.g. to produce a bulletin of automatically detected events); the Winston software, for data storage and visualization. To monitor and maintain all of the described ISNet instrumentation, and to access, analyze and edit the seismic data produced, we developed a software application, SeismNet Manager, that implements a web-based user interface to a database of all the ISNet information and data. For early warning applications, a high bandwidth radio links backbone is being deployed, interconnecting the LCCs and the Network Control Center in Naples. We developed a software application that processes the live streams of 3-component acceleration from the stations and, while an energetic event is occurring, promptly performs picking, event detection, event location and magnitude estimation. The earthquake location uses an evolutionary, real-time technique based on an equal differential time (EDT) formulation, and a probabilistic approach for describing the hypocenter. This algorithm, at each time step, relies on both the information from

  4. Criteria which determine meronymy of the denotatum 'house' in the phase of selection and classification of research material: Problems and dilemmas

    Directory of Open Access Journals (Sweden)

    Dilparić Branislava M.

    2014-01-01

    ; 2004b; 2006, Croft and Cruse (2004 and Winston, Chaffin and Herrmann (1987 were followed. The segmentation of this 3-D hollow object, illustrated in the paper only with Serbian examples, actually showed that the initial intention of the author - that is, first, to attempt to form a hierarchy of the meronyms and, then, to present their semantic analysis in an order that would reflect their positions in the meronomy and thus the meronymic and co-meronymic 'ties' among them - had been quite ambitious. For, even in this preparatory phase of the study, the meronomy of a house turned out to be just basically a -hierarchical structure; taken in its entirety, however, it represents a tangled and entwined lexical network that is a consequence not only of the very high complexity of the whole broken down, numerous ways of its division, a variety of spatial-temporal relations between it and its parts (or between the parts themselves etc., but also of purely -linguistic phenomena such as a wide denotational range of a great number of meronyms, their polysemy even in the house meronomy itself, and the relation of synonymy and/or hyponymy which many of the meronyms also enter into.

  5. airGRteaching: an R-package designed for teaching hydrology with lumped hydrological models

    Science.gov (United States)

    Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Andréassian, Vazken; Brigode, Pierre

    2017-04-01

    discharges, which are updated immediately (a calibration only needs a couple of seconds or less, a simulation is almost immediate). In addition, time series of internal variables, live-visualisation of internal variables evolution and performance statistics are provided. This interface allows for hands-on exercises that can include for instance the analysis by students of: - The effects of each parameter and model components on simulated discharge - The effects of objective functions based on high flows- or low flows-focused criteria on simulated discharge - The seasonality of the model components. References Winston Chang, Joe Cheng, JJ Allaire, Yihui Xie and Jonathan McPherson (2016). shiny: Web Application Framework for R. R package version 0.13.2. https://CRAN.R-project.org/package=shiny Coron L., Thirel G., Perrin C., Delaigue O., Andréassian V., airGR: a suite of lumped hydrological models in an R-package, Environmental Modelling and software, 2017, submitted. Coron, L., Perrin, C. and Michel, C. (2016). airGR: Suite of GR hydrological models for precipitation-runoff modelling. R package version 1.0.3. https://webgr.irstea.fr/airGR/?lang=en. Olivier Delaigue and Laurent Coron (2016). airGRteaching: Tools to simplify the use of the airGR hydrological package by students. R package version 0.0.1. https://webgr.irstea.fr/airGR/?lang=en R Core Team (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    N.J. Gubser

    1968-01-01

    Full Text Available - Ward H. Goodenough, Frederick Barth, Models of social organization. Royal Anthropological Institute Occasional Paper No. 23. Royal Anthropological Institute of Great Britain and Ireland, London 1966. Pp. vi, 33. - E. Postel-Coster, Carl A. Schmitz, Grundformen der Verwandtschaft. Basler Beiträge zur Geographie und Ethnologie, Ethnologische Reihe Heft I. Pharos-Verlag Hansrudolf Schwabe AG, Basel 1964. 134 pp. - B. Siertsema, John J. Gumperz, “The ethnography of communication”; Special publication of American Anthropologist, Part 2, Vol. 66, no. 6, December 1964. American Anthropological Association, Menasha, Wisconsin, U.S.A., 1964, 186 pp., Dell Hymes (eds. - J. Voorhoeve, William J. Samarin, Field Linguistics. A guide to linguistic fieldwork. Holt, Rinehart & Winston Inc., New York, etc., 1967. X + 246 pp. - P.J.R. Modderman, André Leroi-Gourhan, La geste et la parole. Albin Michel, Paris 1964. 2 dln., 300 en 268 pp. Vele ills. - David F. Pocock, Andre Beteille, Caste, class and power. Changing patterns of stratification in a Tanjore village. University of California Press, Berkeley 1965. 225 pp. - A. Trouwborst, P.C. Lloyd, The new elites of tropical Africa. Studies presented and discussed at the sixth international African seminar at the University of Ibadan, Nigeria, July 1964 . Foreword by Daryll Forde. Introduction by P.C. Lloyd. Published for the International African Institute by the Oxford University Press. London 1966. X + 390 pp. - F.L. van Holthoon, Darryll Forde, West African Kingdoms in the 19th. century. O.U.P. for the International African Institute, London 1967. 281 pp., P.M. Kaberry (eds. - J.J. Romkes, David W. Brokensha, Social change at Larteh, Ghana. Clarendon Press. Oxford University Press. London 1966. 294 pp., 5 plates, 3 maps. - A.J.C. Lach de Bère, Merran Fraenkel, Tribe and class in Monrovia. Oxford University Press for the International African Institute, London, Ibadan, Accra, 1964; 244 blz. - F.L. van

  7. SU-C-BRB-04: Characteristics and Performance Evaluation of the First Commercial MLC for a Robotic Delivery System

    Energy Technology Data Exchange (ETDEWEB)

    Fuerweger, C [Erasmus MC Cancer Institute, Rotterdam (Netherlands); European Cyberknife Center Munich, Munich, DE (Germany); Prins, P; Coskan, H; Heijmen, B [Erasmus MC Cancer Institute, Rotterdam (Netherlands)

    2015-06-15

    Purpose: To assess characteristics and performance of the “Incise™” MLC (41 leaf pairs, 2.5mm width, FFF linac) mounted on the robotic SRS/SBRT platform “CyberKnife M6™” in a pre-clinical 5 months (11/2014–03/2015) test period. Methods: Beam properties were measured with unshielded diodes and EBT3 film. The CyberKnife workspace for MLC was analyzed by transforming robot node coordinates (cranial / body paths) into Euler geometry. Bayouth tests for leaf / bank position accuracy were performed in standard (A/P) and clinically relevant non-standard positions, before and after exercising the MLC for 10+ minutes. Total system and delivery accuracy were assessed in End-to-End tests and dosimetric verification of exemplary plans. Stability over time was evaluated in Picket-Fence-and adapted Winston-Lutz-tests (AQA) for different collimator angles. Results: Penumbrae (80–20%, with 100%=2*dose at inflection point; SAD 80cm; 10cm depth) parallel / perpendicular to leaf motion were 2.87/2.64mm for the smallest (0×76×0.75cm{sup 2}) and 5.34/4.94mm for the largest (9.76×9.75cm{sup 2}) square field. MLC circular field penumbrae exceeded fixed cones by 10–20% (e.g. 60mm: 4.0 vs. 3.6mm; 20mm: 3.6 vs. 2.9mm). Interleaf leakage was <0.5%. Clinically accessible workspace with MLC covered (non-coplanar) gantry angles of [-113°;+112°] (cranial) and [-108°;+102°] (body), and collimator angles of [-100°;+107°] (cranial) and [-91°;+100°] (body). Average leaf position offsets were ≤0.2mm in 14 standard A/P Bayouth tests and ≤0.6mm in 8 non-standard direction tests. Pre-test MLC exercise increased jaggedness (range ±0.3mm vs. ±0.5mm) and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.39±0.06mm in 6 End-to-End tests. Picket-Fence and AQA showed no adverse trends during the test period. Conclusion: The Incise™ MLC for CyberKnife M6™ displayed high accuracy and mechanical stability over the test period. The

  8. Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Kempton CL

    2017-09-01

    Full Text Available Christine L Kempton,1 Michael Wang,2 Michael Recht,3 Anne Neff,4 Amy D Shapiro,5 Amit Soni,6 Roshni Kulkarni,7 Tyler W Buckner,2 Katharine Batt,8 Neeraj N Iyer,9 David L Cooper9 1Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA; 2Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, CO, USA; 3The Hemophilia Center, Oregon Health & Science University, Portland, OR, USA; 4Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA; 5Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA; 6Center for Inherited Blood Disorders and CHOC Children’s Hospital/UC Irvine, Orange, CA, USA; 7MSU Center for Bleeding and Clotting Disorders, Michigan State University, East Lansing, MI, USA; 8Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 9Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA Background: Hemophilia is marked by frequent joint bleeding, resulting in pain and functional impairment.Objective: This study aimed to assess the reliability of five patient-reported outcome (PRO instruments in people with hemophilia (PWH in a non-bleeding state.Methods: Adult male PWH of any severity and inhibitor status, with a history of joint pain or bleeding, completed a pain history and five PRO instruments (EQ-5D-5L, Brief Pain Inventory v2 [BPI], International Physical Activity Questionnaire [IPAQ], Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL] during their routine comprehensive care visit. Patients were approached to complete the PRO instruments again at the end of their visit while in a similar non-bleeding state. Concordance of individual questionnaire items and correlation between domain scores were assessed using intra-class correlation coefficient (ICC.Results: Participants completing the retest (n=164 had a median age of 33.9 years. Median time for

  9. Test of variables of attention (TOVA as a predictor of early attention complaints, an antecedent to dementia

    Directory of Open Access Journals (Sweden)

    Eric R Braverman

    2010-10-01

    Full Text Available Eric R Braverman1,5, Amanda Lih-Chuan Chen2, Thomas JH Chen3, John D Schoolfield4, Alison Notaro5, Dasha Braverman5, Mallory Kerner5, Seth H Blum6 , Vanessa Arcuri5, Michael Varshavskiy5, Uma Damle5 , B William Downs7, Roger L Waite7, Marlene Oscar-Berman8, John Giordano9 , Kenneth Blum5,6,7,101Division of Neurological Surgery, Weill Cornell College of Medicine, New York, NY, USA; 2Department of Engineering and Management of Advanced Technology, 3Department of Occupational Safety and Health, Chang Jung Christian University, Tainan, Taiwan Republic of China; 4Department of Periodontics, University of Texas, Health Science Center, San Antonio, TX, USA; 5PATH Research Foundation, New York, NY, USA; 6Department of Nutritional Genomics, Synaptamine, Inc., San Antonio, TX, USA; 7Department of Personalized Medicine, LifeGen, Inc., La Jolla, CA, USA; 8Boston University School of Medicine, Boston VA, Boston, MA, USA; 9Department of Holistic Medicine, G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA; 10Department of Physiology and Pharmacology, University of Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USAAbstract: The goal of this study was to determine if impairments detected by the test of variables of attention (TOVA may be used to predict early attention complaints and memory impairments accurately in a clinical setting. We performed a statistical analysis of outcomes in a patient population screened for attention deficit hyperactivity disorder or attention complaints, processing errors as measured by TOVA and the Wechsler Memory Scale (WMS-III results. Attention deficit disorder (ADD checklists, constructed using the Diagnostic and Statistical Manual of Mental Disorders 4th Edition criteria, which were completed by patients at PATH Medical, revealed that 72.8% of the patients had more than one attention complaint out of a total of 16 complaints, and 41.5% had more than five complaints. For the 128

  10. SU-F-T-647: Linac-Based Stereotactic Radiosurgery (SRS) in the Treatment of Trigeminal Neuralgia: Detailed Description of SRS Procedural Technique and Reported Clinical Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Pokhrel, D; Sood, S; Badkul, R; Jiang, H; Stepp, T; Camarata, P; Wang, F [University of Kansas Hospital, Kansas City, KS (United States)

    2016-06-15

    Purpose: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. Methods: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009–2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study. Experienced neurosurgeon and radiation oncologist delineated the TNR on 1.0mm thin 3D-FIESTA-MRI that was co-registered with 0.7mm thin planning-CT. Treatment plans were generated in iPlan (BrainLAB) with a 4-mm diameter cone using 79 arcs with differential-weighting for Novalis-TX 6MV-SRS(1000MU/min) beam and optimized to minimize brainstem dose. Winston-Lutz test was performed before each treatment delivery with sub-millimeter isocenter accuracy. Quality assurance of frame placement was maintained by helmet-bobble-measurement before simulation-CT and before patient setup at treatment couch. OBI-CBCT scan was performed for patient setup verification without applying shifts. On clinical follow up, treatment response was assessed using Barrow Neurological Institute Pain Intensity Score(BNI-score:I–V). Results: 26/28 TNR-patients (16-males/10-females) who were treated with following single-fraction point-dose to isocenter: 80Gy(n=22),75Gy(n=1),70Gy(n=2) and 60Gy(n=1, re-treatment) were followed up. Median follow-up interval was 8.5-months (ranged:1–48.5months). Median age was 70-yr (ranged:43–93-yr). Right/left TNR ratio was 15/11. Delivered total # of average MUs was 19034±1204. Average beam-on-time: 19.0±1.3min. Brainstem max-dose and dose to 0.5cc were 13.3±2.4Gy (ranged:8.1–16.5Gy) and 3.6±0.4Gy (ranged:3.0–4.9Gy). On average, max-dose to optic-apparatus was ≤1.2Gy. Mean value of max-dose to eyes/lens was 0.26Gy/0.11Gy

  11. Associations of sleep disturbance and duration with metabolic risk factors in obese persons with type 2 diabetes: data from the Sleep AHEAD Study

    Directory of Open Access Journals (Sweden)

    St-Onge MP

    2012-12-01

    Full Text Available Marie-Pierre St-Onge,1 Gary Zammit,2 David M Reboussin,3 Samuel T Kuna,4 Mark H Sanders,8 Richard Millman,6 Anne B Newman,5 Thomas A Wadden,4 Rena R Wing,6 F Xavier Pi-Sunyer,1 Gary D Foster7 Sleep AHEAD Research Group*1New York Obesity Research Center, St Luke's/Roosevelt Hospital, New York, NY, USA; 2Clinilabs, New York, NY, USA; 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; 5Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA; 6Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA; 7Center for Obesity Research and Education, Temple University, Philadelphia, PA, USA; 8Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, PA, USA*A full list of the members of the Sleep AHEAD Research Group is available in an online appendixPurpose: Some studies have found an association between sleep disturbances and metabolic risk, but none has examined this association in individuals with type 2 diabetes. The objective of this study was to determine the relationship between sleep disturbances and metabolic risk factors in obese patients with type 2 diabetes.Patients and methods: This study was a cross-sectional examination of the relationship between sleep parameters (apnea/hypopnea index [AHI], time spent in various sleep stages and metabolic risk markers (fasting glucose, hemoglobin A1c, lipids using baseline data of the Sleep AHEAD cohort. Subjects (n = 305 were participants in Sleep AHEAD (Action for Health in Diabetes, a four-center ancillary study of the Look AHEAD study, a 16-center clinical trial of overweight and obese participants with type 2 diabetes, designed to assess the long-term effects of an intensive lifestyle intervention on cardiovascular events. All participants underwent one night of in-home polysomnography

  12. Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors

    Directory of Open Access Journals (Sweden)

    Rossmeisl JH

    2017-04-01

    Full Text Available John H Rossmeisl,1–3 Kelli Hall-Manning,4 John L Robertson,1,3,5 Jamie N King,1,2 Rafael V Davalos,3,5 Waldemar Debinski,3 Subbiah Elankumaran6,† 1Veterinary and Comparative Neuro-Oncology Laboratory, 2Department of Small Animal Clinical Sciences, 3The Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, NC, 4Virginia Tech Animal Laboratory Services, Virginia-Maryland College of Veterinary Medicine, 5Department of Biomedical Engineering and Mechanics, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Virginia Tech, 6Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA†The authors regret to advise of the passing of Dr Subbiah Elankumaran prior to publicationBackground: The expression of the urokinase plasminogen activator receptor (uPAR, a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA, have been associated with the invasive and metastatic potentials of a variety of human brain tumors through their regulation of extracellular matrix degradation. Domesticated dogs develop naturally occurring brain tumors that share many clinical, phenotypic, molecular, and genetic features with their human counterparts, which has prompted the use of the dogs with spontaneous brain tumors as models to expedite the translation of novel brain tumor therapeutics to humans. There is currently little known regarding the role of the uPA system in canine brain tumorigenesis. The objective of this study was to characterize the expression of uPAR and the activity of uPA in canine brain tumors as justification for the development of uPAR-targeted brain tumor therapeutics in dogs.Methods: We investigated the expression of uPAR in 37 primary canine brain tumors using immunohistochemistry, Western blotting, real

  13. The Role of Fluid Dynamics in Distributing Ankle Stresses in Anatomic and Injured States.

    Science.gov (United States)

    Hamid, Kamran S; Scott, Aaron T; Nwachukwu, Benedict U; Danelson, Kerry A

    2016-12-01

    In 1976, Ramsey and Hamilton published a landmark cadaveric study demonstrating a dramatic 42% decrease in tibiotalar contact area with only 1 mm of lateral talar shift. An increase in maximum principal stress of at least 72% is predicted based on these findings though the delayed development of arthritis in minimally misaligned ankles does not appear to be commensurate with the results found in dry cadaveric models. We hypothesized that synovial fluid could be a previously unrecognized factor that contributes significantly to stress distribution in the tibiotalar joint in anatomic and injured states. As it is not possible to directly measure contact stresses with and without fluid in a cadaveric model, finite element analysis (FEA) was employed for this study. FEA is a modeling technique used to calculate stresses in complex geometric structures by dividing them into small, simple components called elements. Four test configurations were investigated using a finite element model (FEM): baseline ankle alignment, 1 mm laterally translated talus and fibula, and the previous 2 bone orientations with fluid added. The FEM selected for this study was the Global Human Body Models Consortium-owned GHBMC model, M50 version 4.2, a model of an average-sized male (distributed by Elemance, LLC, Winston-Salem, NC). The ankle was loaded at the proximal tibia with a distributed load equal to the GHBMC body weight, and the maximum principal stress was computed. All numerical simulations were stable and completed with no errors. In the baseline anatomic configuration, the addition of fluid between the tibia, fibula, and talus reduced the maximum principal stress computed in the distal tibia at maximum load from 31.3 N/mm 2 to 11.5 N/mm 2 . Following 1 mm lateral translation of the talus and fibula, there was a modest 30% increase in the maximum stress in fluid cases. Qualitatively, translation created less high stress locations on the tibial plafond when fluid was incorporated into

  14. Attention-deficit-hyperactivity disorder and reward deficiency syndrome

    Directory of Open Access Journals (Sweden)

    Kenneth Blum

    2008-11-01

    Full Text Available Kenneth Blum1,6,7,8,9,10, Amanda Lih-Chuan Chen2, Eric R Braverman3,9, David E Comings4, Thomas JH Chen5, Vanessa Arcuri9, Seth H Blum6, Bernard W Downs7,8, Roger L Waite7, Alison Notaro9, Joel Lubar10, Lonna Williams7, Thomas J Prihoda11, Tomas Palomo12, Marlene Oscar-Berman131Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC; 2Department of Engineering and Management of Advanced Technology, Chang Jung University, Tainan, Taiwan, Republic of China; 3Department of Neurosurgery, Weill College of Medicine, New York, NY; 4Department of Medical Genetics, City of Hope Medical Center, Duarte, CA; 5Department of Occupational Safety and Health, Chang Jung University, Tainan, Taiwan, Republic of China; 6Department of Psychoneurogenetics, Synapatamine, Inc., San Antonio, TX; 7LifeGen, Inc., La Jolla, CA; 8Allied Nutraceutical Research, Lederach, PA; 9PATH Research Foundation, New York, NY; 10Department of Physiology, University of Tennessee, Knoxville, TN; 11Department of Pathology, University of Texas Health Science Center, San Antonio, TX; 12Hospital Universitario 12 de Octubre, Madrid, Spain; 13Boston University School of Medicine, and Boston VA Healthcare System, Boston, MAParts of this manuscript have been published in Theor Biol Med Model (Comings et al 2005, which is an open access journalAbstract: Molecular genetic studies have identified several genes that may mediate susceptibility to attention deficit hyperactivity disorder (ADHD. A consensus of the literature suggests that when there is a dysfunction in the “brain reward cascade,” especially in the dopamine system, causing a low or hypo-dopaminergic trait, the brain may require dopamine for individuals to avoid unpleasant feelings. This high-risk genetic trait leads to multiple drug-seeking behaviors, because the drugs activate release of dopamine, which can diminish abnormal cravings. Moreover, this genetic trait is due in part to a

  15. SU-C-BRB-04: Characteristics and Performance Evaluation of the First Commercial MLC for a Robotic Delivery System

    International Nuclear Information System (INIS)

    Fuerweger, C; Prins, P; Coskan, H; Heijmen, B

    2015-01-01

    Purpose: To assess characteristics and performance of the “Incise™” MLC (41 leaf pairs, 2.5mm width, FFF linac) mounted on the robotic SRS/SBRT platform “CyberKnife M6™” in a pre-clinical 5 months (11/2014–03/2015) test period. Methods: Beam properties were measured with unshielded diodes and EBT3 film. The CyberKnife workspace for MLC was analyzed by transforming robot node coordinates (cranial / body paths) into Euler geometry. Bayouth tests for leaf / bank position accuracy were performed in standard (A/P) and clinically relevant non-standard positions, before and after exercising the MLC for 10+ minutes. Total system and delivery accuracy were assessed in End-to-End tests and dosimetric verification of exemplary plans. Stability over time was evaluated in Picket-Fence-and adapted Winston-Lutz-tests (AQA) for different collimator angles. Results: Penumbrae (80–20%, with 100%=2*dose at inflection point; SAD 80cm; 10cm depth) parallel / perpendicular to leaf motion were 2.87/2.64mm for the smallest (0×76×0.75cm 2 ) and 5.34/4.94mm for the largest (9.76×9.75cm 2 ) square field. MLC circular field penumbrae exceeded fixed cones by 10–20% (e.g. 60mm: 4.0 vs. 3.6mm; 20mm: 3.6 vs. 2.9mm). Interleaf leakage was <0.5%. Clinically accessible workspace with MLC covered (non-coplanar) gantry angles of [-113°;+112°] (cranial) and [-108°;+102°] (body), and collimator angles of [-100°;+107°] (cranial) and [-91°;+100°] (body). Average leaf position offsets were ≤0.2mm in 14 standard A/P Bayouth tests and ≤0.6mm in 8 non-standard direction tests. Pre-test MLC exercise increased jaggedness (range ±0.3mm vs. ±0.5mm) and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.39±0.06mm in 6 End-to-End tests. Picket-Fence and AQA showed no adverse trends during the test period. Conclusion: The Incise™ MLC for CyberKnife M6™ displayed high accuracy and mechanical stability over the test period. The specific Cyber

  16. Waste is a Terrible Thing to Mind: Perspectives on the Cleanup of the United States Nuclear Weapons Complex

    Science.gov (United States)

    Bodde, David

    1997-03-01

    Symposium will address this cleanup from the perspective of contemporary issues, rather than the mistakes of the past. Dr. David Bodde, currently Co-Chair of the Environmental Management Advisory Board, which advises the DoE on technical and policy issues pertaining to the cleanup, will chair the Symposium. Dr. Frank Parker, Distinguished Professor of Environmental and Water Resources Engineering at Vanderbilt University, will provide a general description of these problems and issues, including cultural and historical factors, a technical description of the wastes, and what is physically required for resolution. The Honorable Alvin Alm, Assistant Secretary of Energy for Environmental Management, will describe the current strategy for solving the problem, how this differs from approaches used in the past, what can realistically be accomplished and when and at what cost. Mr. Thomas Winston of the Ohio Environmental Protection Agency, will present the perspective of the affected localities. And Dr. Charles Powers, Executive Director of the Environmental and Occupational Health Sciences Institute, will speak to the current role and future prospects for risk analysis in improving the allocation of resources for cleanup.

  17. Integration of the digital technologies in the teaching of astronomy

    Science.gov (United States)

    de Macedo, J. A.; Voelzke, M. R.

    2014-08-01

    has researched little or no knowledge of astronomy-related topics, which can be explained by the exclusion of astronomy in basic education in Brazil; (iii) the analysis of the final questionnaire showed that there was significant learning (Ausubel; Novak and Hanesian, 1978), since the results indicate a significant improvement in student responses, (iv) the results indicate a high level of student satisfaction, and; (v) viability of resource use involving digital technologies in the teaching of astronomy, which may contribute to the broadening of methodological options of future teachers and meet their training needs. When the study of sciences takes place without interaction with natural and technological phenomena, a huge gap in the education of students occurs. In this sense, the use of different resources such as models, observations, real and virtual experiments, animations, simulations, video classes, can arouse students' interest in the conceptual content, different from what occurs when the study permits only using conventional resources, as books and handouts. D.P. Ausubel; J.D. Novak; H. Hanesian. Educational psychology: a cognitive view. 2nd. ed. New York: Holt, Rinehart and Winston, 1978. 733p. M. R. Voelzke; E. P. Gonzaga. Analysis of the astronomical concepts presented by teachers of some brazilian state schools. Journal of Science Education, v. 14, n.1, 23-25, 2013.

  18. Characteristics of a novel treatment system for linear accelerator-based stereotactic radiosurgery.

    Science.gov (United States)

    Wen, Ning; Li, Haisen; Song, Kwang; Chin-Snyder, Karen; Qin, Yujiao; Kim, Jinkoo; Bellon, Maria; Gulam, Misbah; Gardner, Stephen; Doemer, Anthony; Devpura, Suneetha; Gordon, James; Chetty, Indrin; Siddiqui, Farzan; Ajlouni, Munther; Pompa, Robert; Hammoud, Zane; Simoff, Michael; Kalkanis, Steven; Movsas, Benjamin; Siddiqui, M Salim

    2015-07-08

    deviation between the OSMS and CBCT was -0.4 ± 0.2 mm, 0.1± 0.3mm, and 0.0 ± 0.1 mm in the vertical, longitudinal, and lateral directions. The mean values and standard deviations of the average deviation and maximum deviation of the daily Winston-Lutz tests over three months are 0.20 ± 0.03 mm and 0.66 ± 0.18 mm, respectively. Initial testing of this novel system demonstrates the technology to be highly accurate and suitable for frameless, linac-based SRS and SBRT treatment.

  19. Construct validity of patient-reported outcome instruments in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Batt K

    2017-08-01

    Full Text Available Katharine Batt,1 Michael Recht,2 David L Cooper,3 Neeraj N Iyer,3 Christine L Kempton4 1Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, 2The Hemophilia Center, Oregon Health & Science University, Portland, OR, 3Novo Nordisk Inc., Plainsboro, NJ, 4Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA Background: People with hemophilia (PWH experience frequent joint bleeding, resulting in pain and functional impairment. Generic and disease-specific patient-reported outcome (PRO instruments have been used in clinical studies, but rarely in the comprehensive hemophilia care setting. Objective: The objective of this study was to assess construct validity of PRO instruments measuring pain, functional impairment, and health-related quality of life in US PWH with a history of joint pain/bleeding. Methods: Adult male PWH completed 4 PRO instruments (EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], SF-36v2, Hemophilia Activities List [HAL] and underwent a musculoskeletal examination (Hemophilia Joint Health Score v2.1 [HJHS]. Construct validity between index and domain scores was evaluated by Pearson product-moment correlation coefficient. Results: A total of 381 PWH were enrolled. EQ-5D-5L Mobility correlated with BPI, SF-36v2, and HAL domains related to pain, physical function, and activity of the lower extremities. EQ-5D-5L Self-Care correlated only with HAL Self-Care. EQ-5D-5L Usual Activities correlated with BPI Pain Interference and domains within SF-36v2 and HAL related to pain and physical function/activities (particularly those involving the lower extremities. EQ-5D-5L Pain/Discomfort correlated with Bodily Pain and Physical Summary on SF-36v2, HAL Overall Activity, and all BPI pain domains. EQ-5D-5L Anxiety/Depression correlated with social/emotional/mental aspects of SF-36v2. On BPI, most pain domains correlated with Bodily

  20. SUPPORT FOR HU CFRT SUMMER HIGH SCHOOL FUSION WORKSHOP

    Energy Technology Data Exchange (ETDEWEB)

    Punjabi, Alkesh

    2010-02-09

    researchers in the HU CFRT mentor the students during summers. Mentors spend a considerable amount of time and efforts in training, teaching, guiding and supervising research projects. The HU CFRT has so far conducted nine workshops during the summers of 1996-2000 and 2002-2005. The first workshop was conducted in summer 1996. Students for the workshop are chosen from a national pool of exceptionally talented high school rising seniors/juniors. To our knowledge, most of these students have gone on to prestigious universities such as Duke University, John Hopkins University, CalTech, UCLA, Hampton University, etc. after completing their high school. For instance, Tiffany Fisher, participant of the 1996 summer workshop completed her BS in Mathematics at Hampton University in May 2001. She then went on to Wake Forest University at Winston-Salem, North Carolina to pursue graduate studies. Anshul Haldipur, participant of the 1999 summer workshop, began his undergraduate studies at Duke University in 2000. Christina Nguyen and Ilissa Martinez, participants of the 2000 summer workshop, are pursuing their undergraduate degrees at the UCLA and Florida State University respectively. The organizing committee of the APS DPP annual meeting invited Dr. Punjabi to deliver an invited talk on training the next generation of fusion scientists and engineers at the 2005 APS DPP meeting in Denver, CO. The organizing committee distributed a special flier with the Bulletin to highlight this invited talk and another talk on education as well the expo. This has given wide publicity and recognition to our workshops and Hampton University. Prof. Punjabi's talk: 'LI2 2: Training the next generation of fusion scientists and engineers: summer high school fusion science workshop, Bull. Amer. Phys. Soc. 50, 221 (2005)' was very well-received. He talked about HU education and outreach initiative and the HU CFRT Summer High School Workshop. The audience had a considerable number of questions

  1. SUPPORT FOR HU CFRT SUMMER HIGH SCHOOL FUSION WORKSHOP

    International Nuclear Information System (INIS)

    Punjabi, Alkesh

    2010-01-01

    researchers in the HU CFRT mentor the students during summers. Mentors spend a considerable amount of time and efforts in training, teaching, guiding and supervising research projects. The HU CFRT has so far conducted nine workshops during the summers of 1996-2000 and 2002-2005. The first workshop was conducted in summer 1996. Students for the workshop are chosen from a national pool of exceptionally talented high school rising seniors/juniors. To our knowledge, most of these students have gone on to prestigious universities such as Duke University, John Hopkins University, CalTech, UCLA, Hampton University, etc. after completing their high school. For instance, Tiffany Fisher, participant of the 1996 summer workshop completed her BS in Mathematics at Hampton University in May 2001. She then went on to Wake Forest University at Winston-Salem, North Carolina to pursue graduate studies. Anshul Haldipur, participant of the 1999 summer workshop, began his undergraduate studies at Duke University in 2000. Christina Nguyen and Ilissa Martinez, participants of the 2000 summer workshop, are pursuing their undergraduate degrees at the UCLA and Florida State University respectively. The organizing committee of the APS DPP annual meeting invited Dr. Punjabi to deliver an invited talk on training the next generation of fusion scientists and engineers at the 2005 APS DPP meeting in Denver, CO. The organizing committee distributed a special flier with the Bulletin to highlight this invited talk and another talk on education as well the expo. This has given wide publicity and recognition to our workshops and Hampton University. Prof. Punjabi's talk: 'LI2 2: Training the next generation of fusion scientists and engineers: summer high school fusion science workshop, Bull. Amer. Phys. Soc. 50, 221 (2005)' was very well-received. He talked about HU education and outreach initiative and the HU CFRT Summer High School Workshop. The audience had a considerable number of questions about our

  2. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-07-01

    Full Text Available -Alan L. Karras, Lauren A. Benton, Law and colonial cultures: Legal regimes in world history, 1400-1900. Cambridge: Cambridge University Press, 2002. xiii + 285 pp. -Sidney W. Mintz, Douglass Sullivan-González ,The South and the Caribbean. Jackson: University Press of Mississippi, 2001. xii + 208 pp., Charles Reagan Wilson (eds -John Collins, Peter Redfield, Space in the tropics: From convicts to rockets in French Guiana. Berkeley: University of California Press, 2000. xiii + 345 pp. -Vincent Brown, Keith Q. Warner, On location: Cinema and film in the Anglophone Caribbean. Oxford: Macmillan, 2000. xii + 194 pp. -Ann Marie Stock, Jacqueline Barnitz, Twentieth-century art of Latin America. Austin: University of Texas Press, 2001. 416 pp. -Ineke Phaf, J.J. Oversteegen, Herscheppingen: De wereld van José Maria Capricorne. Emmastad, Curacao: Uitgeverij ICS Nederland/Curacao, 1999. 168 pp. -Halbert Barton, Frances R. Aparicio, Listening to Salsa: Gender, latin popular music, and Puerto Rican cultures. Hanover NH: Wesleyan University Press, 1998. xxi + 290 pp. -Pedro Pérez Sarduy, John M. Kirk ,Culture and the Cuban revolution: Conversations in Havana. Gainesville: University Press of Florida, 2001. xxvi + 188 pp., Leonardo Padura Fuentes (eds -Luis Martínez-Fernández, Damián J. Fernández, Cuba and the politics of passion. Austin: University of Texas Press, 2000. 192 pp. -Eli Bartra, María de Los Reyes Castillo Bueno, Reyita: The life of a black Cuban woman in the twentieth century. Durham NC: Duke University Press, 2000. 182 pp. -María del Carmen Baerga, Felix V. Matos Rodríguez, Women and urban change in San Juan, Puerto Rico, 1820-1868. Gainesville: University Press of Florida, 1999. xii + 180 pp. [Reissued in 2001 as: Women in San Juan, 1820-1868. Princeton NJ: Markus Weiner Publishers.] -Kevin A. Yelvington, Winston James, Holding aloft the banner of Ethiopa: Caribbean radicalism in early twentieth-century America. New York: Verso, 1998

  3. Formal Semantics: Origins, Issues, Early Impact

    Directory of Open Access Journals (Sweden)

    Barbara H. Partee

    2010-12-01

    Full Text Available Formal semantics and pragmatics as they have developed since the late 1960's have been shaped by fruitful interdisciplinary collaboration among linguists, philosophers, and logicians, among others, and in turn have had noticeable effects on developments in syntax, philosophy of language, computational linguistics, and cognitive science.In this paper I describe the environment in which formal semantics was born and took root, highlighting the differences in ways of thinking about natural language semantics in linguistics and in philosophy and logic. With Montague as a central but not solo player in the story, I reflect on crucial developments in the 1960's and 70's in linguistics and philosophy, and the growth of formal semantics and formal pragmatics from there. I discuss innovations, key players, and leading ideas that shaped the development of formal semantics and its relation to syntax, to pragmatics, and to the philosophy of language in its early years, and some central aspects of its early impact on those fields.ReferencesAbbott, B. 1999. ‘The formal approach to meaning: Formal semantics and its recent developments’. Journal of Foreign Languages (Shanghai119, no. 1: 2–20. https://www.msu.edu/~abbottb/formal.htm.Ajdukiewicz, K. 1960. Je¸zyk i Poznanie (Language and Knowledge. Warsaw.Bach, E. 1968. ‘Nouns and Noun Phrases’. In E. Bach & R.T. Harms (eds. ‘Universals in Linguistic Theory’, 90–122. NY: Holt, Rinehart & Winston.Bach, E. 1989. Informal Lectures on Formal Semantics. New York: State University of New York Press.Bar-Hillel, Y. 1954a. ‘Logical syntax and semantics’. Language 30: 230–237.http://dx.doi.org/10.2307/410265Bar-Hillel, Y. 1954b. ‘Indexical Expressions’. Mind 63: 359–379.http://dx.doi.org/10.1093/mind/LXIII.251.359Bar-Hillel, Y. 1963. ‘Remarks on Carnap’s Logical Syntax of Language’. In P. A. Schilpp (ed. ‘The Philosophy of Rudolf Carnap’, 519–543. LaSalle, Illinois / London: Open

  4. Three essays on the incentive structure of energy conservation programs

    Science.gov (United States)

    Okwelum, Edson Ogochukwu

    of it being involved in a fatal accident. The external costs translate to about 38 cents/gallon of gasoline. Chapter III explores how individual unobserved heterogeneity in tastes could lead to different customers sorting into different classes of fuel efficient vehicles and therefore affect estimates of consumer's ability to tradeoff vehicle costs and discounted future gasoline costs. The research question is important for several reasons. First, it is interesting from a theoretical basis if consumers make this trade off optimally. Many theoretical models in economics make the fundamental assumption that consumers equally weigh current and future events when making decisions today. However, plenty empirical and laboratory evidence conclude the contrary. Second, Regulatory Impact Analyses (RIA) of regulations on energy efficiency standards usually find that the benefits of these programs are in many times larger than the costs, with the fuel savings over the life of the vehicle accounting for the majority of the benefits. However, if fuel savings are large relative to costs, then the question is why are manufacturers not incorporating these technologies in their product offerings? Therefore understanding energy paradox is critical for evaluating the standards and regulations so that policy makers can identify baseline for assessment in cost-benefit analyses. In this paper, we contribute to the literature on Energy Paradox in Fuel Economy by providing empirical evidence that unobserved consumer heterogeneity could result in different consumers sorting into different classes of fuel efficient cars which results in consumers undervaluing fuel economy. Unlike existing literature in this topic, this paper accounts for sorting bias due unobserved heterogeneity by using a random coefficient logit with error components (Train and Winston 2007). We pair the random coefficient discrete choice model with a supply side model in which firms compete in Bertrand Nash fashion where