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  1. El Paciente Winston Churchill

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2000-12-01

    Full Text Available

    El 24 de enero de 1965 moría Sir Winston Churchill, unos dos meses después de haber cumplido su nonagésimo aniversario y a los 9 días de haber entrado en coma por un tercer y último accidente cerebro vascular.

    Fue un hombre extraordinario, el mejor estadista que ha tenido Inglaterra y uno de los personajes
    más importantes del siglo XX.

    Fue longevo a pesar de su agitada existencia y de la presencia de muchas dolencias que le aquejaron, confirmando aquel dicho de que los más enfermos son los que más viven. Recordando el libro de Accoce “Los enfermos que nos gobiernan”, y habiendo visitado la casa de Chartwell en unas vacaciones en el Reino Unido, el académico Ricardo Rueda González se dedicó a investigar y a conseguir datos sobre la historia médica de Winston Spencer Churchill, logrando en medio de apuntes de aquí y de allá, y con la ayuda de personal de nuestra corporación, la elaboración de un estupendo libro con ese título, en buena hora publicado por la Universidad Javeriana.

    Sobra decir que esta muy bien escrita obra se la lee uno de un tirón, dado el estilo fácil del autor, lo bien documentada que está y el interesante anecdotario, pues la vida de este gigante de la raza humana fue una permanente anécdota. Dice el prologuista Alberto Dangond Uribe, experto en el tema, lo siguiente: “En el curso de esa larga vida, tan intensa y tan activa, la envoltura mortal de Winston Churchill atravesará con éxito, peligros innumerables, accidentes y enfermedades de diversa índole...

  2. DVD. Winston Churchilli peredraama / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2006-01-01

    Sir Winston Churchilli isikut avav mängufilm "Tormihoiatus" ("The Gathering Storm") : režissöör Richard Loncraine : peaosas Albert Finney : Suurbritannia - Ameerika Ühendriigid 2002. DVD-d levitab Sonatiin

  3. The Winston Churchill Memorial Trust of Australia

    Science.gov (United States)

    Hilton, Nicolette

    2013-01-01

    The Churchill Trust was established in 1965 to honour the memory of Sir Winston Churchill by awarding overseas research Fellowships known as "Churchill Fellowships". Since its inception, The Churchill Trust has awarded Churchill Fellowships to more than 3,700 Australians who, like Churchill, are innovative, filled with a spirit of…

  4. Winston-Lutz Test: A quantitative analysis

    International Nuclear Information System (INIS)

    Pereira, Aline Garcia; Nandi, Dorival Menegaz; Saraiva, Crystian Wilian Chagas

    2017-01-01

    Objective: Describe a method of quantitative analysis for the Winston-Lutz test. Materials and methods The research is a qualitative exploratory study. The materials used were: portal film; Winston- Lutz test tools and Omni Pro software. Sixteen portal films were used as samples and were analyzed by five different technicians to measure the deviation between the radiation isocenters and mechanic. Results: Among the results were identified two combinations with offset values greater than 1 mm. In addition, when compared the method developed with the previously studied, it was observed that the data obtained are very close, with the maximum percentage deviation of 32.5%, which demonstrates its efficacy in reducing dependence on the performer. Conclusion: The results show that the method is reproducible and practical, which constitutes one of the fundamental factors for its implementation. (author)

  5. Winston-Lutz Test: A quantitative analysis; Teste de Winston-Lutz: uma analise quantitativa

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Aline Garcia; Nandi, Dorival Menegaz; Saraiva, Crystian Wilian Chagas, E-mail: dnandi@gmail.com [Universidade Federal de Santa Catarina (UFSC), Florianopolis (Brazil); Instituto Federal de Santa Catarina (IFSC), Florianopolis (Brazil); Hospital do Coracao, Sao Paulo, SP (Brazil)

    2017-11-01

    Objective: Describe a method of quantitative analysis for the Winston-Lutz test. Materials and methods The research is a qualitative exploratory study. The materials used were: portal film; Winston- Lutz test tools and Omni Pro software. Sixteen portal films were used as samples and were analyzed by five different technicians to measure the deviation between the radiation isocenters and mechanic. Results: Among the results were identified two combinations with offset values greater than 1 mm. In addition, when compared the method developed with the previously studied, it was observed that the data obtained are very close, with the maximum percentage deviation of 32.5%, which demonstrates its efficacy in reducing dependence on the performer. Conclusion: The results show that the method is reproducible and practical, which constitutes one of the fundamental factors for its implementation. (author)

  6. Winston Churchill And The European Union

    Directory of Open Access Journals (Sweden)

    Troitiño David Ramiro

    2015-06-01

    Full Text Available Given Winston Churchill’s influence and achievement as a writer, historian, adventurer, soldier, artist, and politician, his participation in the European integration process is crucial to understanding the entire scope of the project in its origins. Churchill was a fundamental voice promoting the Franco-British Union, a promoter of the European Communities, and an active participant of the Congress of Europe, embryo of the Council of Europe. This article analyzes Churchill’s view of European integration through his political speeches, in particular those delivered in Zurich and in The Hague, his ideas about the League of Nations and the United Nations, his understanding of the British Empire, and the special relations between the UK and the USA. His participation in the process of uniting Europe in its early stages provides us with essential information about the original plans for the creation of a united Europe and understanding the traditional British approach to the EU, including the current position of the conservative government led by Cameron.

  7. Winston Churchill's "Iron Curtain" Address: Implications for the Present.

    Science.gov (United States)

    Bush, George

    1988-01-01

    Evaluates the "Iron Curtain" speech made by Winston Churchill in 1946, discussing its relevance and implications for the present. Examines Churchill's predictions for the future and his assessment of the USSR. Reviews world developments since the speech and proposes foreign policy goals for the next 40 years. (GEA)

  8. Market Segmentation, Targeting, Dan Brand Positioning Dari Winston Premier Surabaya

    OpenAIRE

    Tania, Debby

    2014-01-01

    Sejak tahun 2012 mulai terasa bahwa bisnis properti mengalami kenaikan di Indonesia. Banyak masyarakat Indonesia berinvestasi pada properti karena dianggap aman dan menguntungkan. Sehingga muncul banyak produk properti baru di Indonesia. Perkembangan properti di Indonesia menjadi peluang besar bagi Agen Properti untuk dapat menjalankan bisnisnya. Winston Premier sebagai salah satu Agen properti di Surabaya Barat yang baru berdiri memerlukan strategi pemasaran yang tepat untuk digunakan guna b...

  9. STS-87 Mission Specialist Winston E. Scott suits up

    Science.gov (United States)

    1997-01-01

    STS-87 Mission Specialist Winston Scott dons his launch and entry suit with the assistance of a suit technician in the Operations and Checkout Building. This is Scotts second space flight. He and the five other crew members will depart shortly for Launch Pad 39B, where the Space Shuttle Columbia awaits liftoff on a 16-day mission to perform microgravity and solar research. Scott is scheduled to perform an extravehicular activity spacewalk with Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, during STS-87. He also performed a spacewalk on STS-72.

  10. Geothermal Exploration of the Winston Graben, Central New Mexico, USA

    Science.gov (United States)

    Sophy, M. J.; Kelley, S. A.

    2011-12-01

    We are assessing the geothermal potential of the Winston Graben of central New Mexico using borehole temperature logs and geophysical data. The Winston Graben is a late Cenozoic rift basin, part of the larger Rio Grande rift, which is 5 to 10 km wide and 56 km long with northern and southern termini occurring at accommodation zones that coincide with late Cenozoic volcanic lineaments. The graben is interpreted to be symmetric based on geologic mapping, with 2 km of stratigraphic offset on both the western and eastern margins. The graben is bordered by the Black Range to the west and is separated from the Rio Grande valley by the Sierra Cuchillo, a horst block made of Paleozoic rocks intruded by a laccolith. Geothermal and geophysical data, including water table measurements, well temperature logs, thermal conductivity samples, bottom hole temperatures, water chemistry, and gravity data have been extracted from the New Mexico Geothermal Database, part of the National Geothermal Database, and the Geonet Gravity and Magnetic Dataset Repository. Combined with existing geologic maps of the Winston Graben and surroundings, these data help to identify spatial relationships between geologic structures and groundwater parameters and distribution. Geothermal gradients from industry temperature-depth well profiles range from 20°C/km to 60°C/km with a spatial distribution of higher gradients located on the eastern side of the Sierra Cuchillo horst, which is where a mapped warm spring is located. Lower thermal gradients were observed to the west in the groundwater recharge area of the basin. Analysis of Bouguer gravity data indicate a gravity low coinciding with the center of the Winston Graben, which is attributed to be the deepest part of the basin, symetrically surrounded by gravity highs. Gravity highs coincide with the middle Cenozoic Morenci and Chise volcanic lineaments along the northern and southern ends of the graben. The mapped warm spring occurs at the

  11. Design Level Ship Shock Simulation of USS WINSTON S. CHURCHILL (DDG-81)

    National Research Council Canada - National Science Library

    Fensterer, William

    2004-01-01

    .... The Navy selected the Arleigh Burke class destroyer, USS WINSTON S. CHURCHILL (DDG-81), as the most recent platform and subjected it to an underwater explosion two-thirds the magnitude of the design level shot...

  12. Beyond the Criminal Arena: The Justice Studies Program at Winston-Salem State University

    Science.gov (United States)

    Harvey, Lynn K.; Mitchell, Alvin D.

    2006-01-01

    The justice studies program at Winston-Salem State University (WSSU) is designed to produce a new breed of justice practitioners whose understanding of justice and its administration is broadened to include the political, social, economic, and cultural conditions within which issues of crime and punishment are pursued and addressed. While it…

  13. Winston Spencer Churchill. Sus Enfermedades y la Medicina de su Época.

    Directory of Open Access Journals (Sweden)

    Ricardo Rueda González

    2008-03-01

    El robusto y rosagante niño Winston fue bautizado en solemne ceremonia el 27 de diciembre de 1874 en la Capilla del Palacio de Blenheim, por el capellán de los duques, el Reverendo Henry Williams Lule y de inmediato fue entregado a la niñera Mrs. Elizabeth Anne Everest, quien se constituyó en su segunda mamá. Everest era una mujer inteligente y bondadosa que supo manejar con profundo cariño y habilidad a Winston hasta su edad adulta. Falleció de una peritonitis a los 68 años, en 1895 cuando su niño consentido contaba apenas con 21 años.

  14. Learning To Lead: How Winston Churchill And George Marshall Harvested Their WWI Experience

    Science.gov (United States)

    2014-04-01

    Borton’s developmental model. Rolfe and Borton references are provided in Bibliography. 4 Kolb , and Kolb . “ Experiential Learning Theory ,” 39. 5...electronically at http://www2.glos.ac.uk/ gdn/gibbs/index.htm Kolb , Alice Y. and David A. Kolb . “ Experiential Learning Theory : A Dynamic, Holistic...1 EXPERIENTIAL LEARNING THEORY ………………………………………………………..2 THE POWER OF SIX—WINSTON

  15. 75 FR 76040 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-12-07

    ..., Winston-Salem, North Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR... from Staffing Solutions, South East, and Omni Resources and Recovery. The notices were published in the... firm. The workers are engaged in employment related to the production of desktop computers. New...

  16. 76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-01-14

    ..., APN and ICONMA, Winston-Salem, North Carolina. The notice was published in the Federal Register on... Seaton Corporation. The notices were published on the Federal Register on April 19, 2010 (75 FR 20385... workers are engaged in employment related to the production of desktop computers. New information shows...

  17. 75 FR 20033 - Winston-Salem Southbound Railway Company-Corporate Family Transaction Exemption-High Point...

    Science.gov (United States)

    2010-04-16

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Finance Docket No. 35338] Winston-Salem Southbound Railway Company--Corporate Family Transaction Exemption--High Point, Thomasville... under 49 CFR 1180.2(d)(3) for a transaction within a corporate family. Applicants state that HPTD will...

  18. SU-E-CAMPUS-T-01: Automation of the Winston-Lutz Test for Stereotactic Radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Litzenberg, D; Irrer, J; Kessler, M; Lam, K [University of Michigan, Ann Arbor, MI (United States); Keranen, W [Varian Medical Systems, Inc., Palo Alto, CA (United States)

    2014-06-15

    Purpose: To optimize clinical efficiency and shorten patient wait time by minimizing the time and effort required to perform the Winston-Lutz test before stereotactic radiosurgery (SRS) through automation of the delivery, analysis, and documentation of results. Methods: The radiation fields of the Winston-Lutz (WL) test were created in a “machine-QA patient” saved in ARIA for use before SRS cases. Images of the BRW target ball placed at mechanical isocenter are captured with the portal imager for each of four, 2cm×2cm, MLC-shaped beams. When the WL plan is delivered and closed, this event is detected by in-house software called EventNet which automates subsequent processes with the aid of the ARIA web services. Images are automatically retrieved from the ARIA database and analyzed to determine the offset of the target ball from radiation isocenter. The results are posted to a website and a composite summary image of the results is pushed back into ImageBrowser for review and authenticated documentation. Results: The total time to perform the test was reduced from 20-25 minutes to less than 4 minutes. The results were found to be more accurate and consistent than the previous method which used radiochromic film. The images were also analyzed with DoseLab for comparison. The difference between the film and automated WL results in the X and Y direction and the radius were (−0.17 +/− 0.28) mm, (0.21 +/− 0.20) mm and (−0.14 +/− 0.27) mm, respectively. The difference between the DoseLab and automated WL results were (−0.05 +/− 0.06) mm, (−0.01 +/− 0.02) mm and (0.01 +/− 0.07) mm, respectively. Conclusions: This process reduced patient wait times by 15–20 minutes making the treatment machine available to treat another patient. Accuracy and consistency of results were improved over the previous method and were comparable to other commercial solutions. Access to the ARIA web services is made possible through an Eclipse co-development agreement

  19. SU-F-T-547: Off-Isocenter Winston-Lutz Test for Stereotactic Radiosurgery/stereotactic Body Radiotherapy

    International Nuclear Information System (INIS)

    Gao, J; Liu, X

    2016-01-01

    Purpose: To perform a quantitative study to verify that the mechanical field center coincides with the radiation field center when both are off from the isocenter during the single-isocenter technique in linear accelerator-based SRS/SBRT procedure to treat multiple lesions. Methods: We developed an innovative method to measure this accuracy, called the off-isocenter Winston-Lutz test, and here we provide a practical clinical guideline to implement this technique. We used ImagePro V.6 to analyze images of a Winston-Lutz phantom obtained using a Varian 21EX linear accelerator with an electronic portal imaging device, set up as for single-isocenter SRS/SBRT for multiple lesions. We investigated asymmetry field centers that were 3 cm and 5 cm away from the isocenter, as well as performing the standard Winston-Lutz test. We used a special beam configuration to acquire images while avoiding collision, and we investigated both jaw and multileaf collimation. Results: For the jaw collimator setting, at 3 cm off-isocenter, the mechanical field deviated from the radiation field by about 2.5 mm; at 5 cm, the deviation was above 3 mm, up to 4.27 mm. For the multileaf collimator setting, at 3 cm off-isocenter, the deviation was below 1 mm; at 5 cm, the deviation was above 1 mm, up to 1.72 mm, which is 72% higher than the tolerance threshold. Conclusion: These results indicated that the further the asymmetry field center is from the machine isocenter, the larger the deviation of the mechanical field from the radiation field, and the distance between the center of the asymmetry field and the isocenter should not exceed 3 cm in of our clinic. We recommend that every clinic that uses linear accelerator, multileaf collimator-based SRS/SBRT perform the off-isocenter Winston-Lutz test in addition to the standard Winston-Lutz test and use their own deviation data to design the treatment plan.

  20. FAKTOR-FAKTOR KEINGINAN PINDAH AGEN REAL ESTATE WINSTON DI SURABAYA

    Directory of Open Access Journals (Sweden)

    Antonius Ricky Hartono

    2015-01-01

    Full Text Available This research was conducted to determine the factors that affect the desire to mo­ve Winston real estate agent in Surabaya. The population in this study amounted to 149 people. The sample of this research used the method of sampling of incidental to the level of a 10% error. Sample of this research as many as 113 people. This research u­sed a quantitative approach. The technique of collecting data used questionnaires com­pleted by respondents. Methods of data analysis that was used by the analysis of the factor. Analysis of the factor was ordained by using program Statistical Package for the So­cial Science (SPSS which consists of two stages: a descriptive analysis and ex­trac­tion. The results of this research show that the factors which affect the desire to move were composed of factors of individual and organizational factors. Individual factors which are more dominant than the system factors of the organization.

  1. Organochlorine accumulation by Sentinel Mallards at the Winston-Thomas sewage treatment plant, Bloomington, Indiana

    Science.gov (United States)

    Custer, T.W.; Sparks, D.W.; Sobiech, S.A.; Hines, R.K.; Melancon, M.J.

    1996-01-01

    Farm-raised l2-month-old female mallards (Anas platyrhynchos) were released at the Winston-Thomas sewage treatment plant, Bloomington, Indiana. Five mallards were sacrificed at the start of the study and at approximately 10-day intervals through day 100. Concentrations of polychlorinated biphenyls (PCBs) in carcasses increased linearly with time of exposure and exceeded 16 mcg/g wet weight by day 100; PCBs in breast muscle exceeded 3.9 mcg/g by day 100. These PCB values are among the highest recorded for wild or sentinel waterfowl. PCB concentrations in breast muscle (26-523 mcg/g lipid weight) were 50-1,000 times greater than human consumption guidelines for edible poultry in Canada (0.5 mcg/g lipid weight) and 9-176 times greater than consumption guidelines for edible poultry in the United States (3.0 mcg/g lipid weight). Additionally, PCB concentrations in carcass and breast muscle exceeded the threshold of the Great Lakes Sport Fish Consumption Advisory 'do not eat' category (1.9 mcg/g wet weight) by day 20 and day 50, respectively. Hepatic cytochrome P450-associated monooxygenases including BROD (benzyloxyresorufin-O-dealkylase), EROD (ethoxyresorufin-O-dealkylase), and PROD (pentoxyresorufin-O-dealkylase) were induced over 5-fold compared to reference mallards. BROD, EROD, and PROD were each significantly correlated to total PCBs and to the toxicity of selected PCB congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

    NARCIS (Netherlands)

    Ingkaninan, K.; Hazekamp, A.; de Best, C.M.; Irth, H.; Tjaden, U.R.; van der Heijden, R.; van der Greef, J.; Verpoorte, R.

    2000-01-01

    An HPLC with on-line coupled UV/MS-biochemical detection method for acetylcholinesterase (AChE) inhibitors in natural sources has been developed. The potential of this method is shown by the isolation of a new AChE inhibitor from the alcoholic extract of Narcissus 'Sir Winston Churchill'. Combining

  3. Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2016-01-01

    This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

  4. Studies in Teaching: 2015 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 25, 2015)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2015-01-01

    This document presents the proceedings of the 20th Annual Research Forum held June 25, 2015, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 21 action research papers: (1) History Lives! The Use of Simulations in a High School Social Studies Classroom (Lydia Adkins); (2) Using Francophone Music in the High…

  5. Studies in Teaching: 2017 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2017)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2017-01-01

    This document presents the proceedings of the 22nd Annual Research Forum held June 29, 2017, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 12 action research papers: (1) Using Captioned Video to Teach Listening Comprehension in a Spanish Classroom (Michelle Allen); (2) Multimodal Instruction: How Film…

  6. Winston Churchill (1874-1965), Dr Robson Roose, MD Brux, FRCPE (1848-1905) and Dr Joseph Rutter, MD Lond, MRCP (1834-1913): Treatment for pneumonia in March 1886.

    Science.gov (United States)

    Vale, J Allister; Scadding, John W

    2018-01-01

    This paper will review Winston Churchill's severe respiratory illness in March 1886 when he developed pneumonia of the right lung as an 11-year-old boy. Winston was treated supportively with 'nourishment, stimulants [probably alcohol] and close watching' at his school by the 'celebrated' family physician, Dr Robson Roose, with the assistance of Dr Joseph Rutter. Roose was exemplary in his commitment to his young patient and assiduous in informing Lord Randolph Churchill of his son's clinical progress by letter.

  7. Sağlık Çalışanlarında Hizmetkâr Liderlik: Dennis-Winston ve Dennis-Bocernea Hizmetkâr Liderlik Ölçeklerinin Geçerlik ve Güvenirlik Araştırması( Servant Leadership Among Medical Staff: Investigation of Validity and Reliability of Dennis-Winston and Dennis-Bocernea Servant Leadership Scales

    Directory of Open Access Journals (Sweden)

    Şebnem ASLAN

    2011-01-01

    Full Text Available This study aims to contribute the two different scales used in evaluation of servant leadership among medical staff on Turkish literature. In this context, validity and reliability analysis of Dennis and Winston (2003 and Dennis and Bocernea (2006 Servant Leadership Scales are done. Dennis and Winston Scale includes 23 questions and 3 dimensions, and Dennis and Bocernea scale includes 29 questions and 7 dimensions. The survey is conducted with 180 staff in practising in three different hospitals of Konya province. The datas obtained from the survey are analysed with descriptive statistics and confirmatory factor analysis using SPSS 16.0 and Lisrel 8 programmes. As a result, Dennis and Bocernea scale is reduced to 5 dimensions and 14 questions, and Dennis and Winston scale to 3 dimensions and 14 questions. The new scale is found as valid and reliable.

  8. NURE aerial gamma-ray and magnetic reconnaissance survey: Blue Ridge area, Greensboro NJ 17-12, Winston-Salem NJ 17-11, and Johnson City NJ 17-10 Quadrangles. Volume I. Narrative report

    International Nuclear Information System (INIS)

    1978-12-01

    As part of the Department of Energy (DOE) National Uranium Resource Evaluation (NURE) Program, LKB Resources, Inc. has performed a rotary-wing, reconnaissance high sensitivity radiometric and magnetic survey in the Blue Ridge area of Virginia, North Carolina, South Carolina, Kentucky, and Tennessee. Five (5) 1:250,000 scale NTMS quadrangles (Greensboro, Winston-Salem, Johnson City, Knoxville, and Charlotte) were surveyed. A total of 15,753 line miles (25,347 kilometers) of data were collected utilizing a Sikorsky S58 and S58T helicopter. Traverse lines were flown in an east-west direction at 3.0 mile (4.8 kilometer) spacing, with tie lines flown in a north-south direction at 12 mile (20 kilometer) spacing. The data were digitally recorded at 1.0 second intervals. The NaI terrestrial detectors used in this survey had a total volume of 2,154 cubic inches. The magnetometer employed was a modified ASQ-10 fluxgate system. This report covers the Greensboro, Winston-Salem, and Johnson City NTMS 1:250,000 scale quadrangles. The Knoxville and Charlotte NTMS 1:250,000 scale quadrangles are covered in a separate report. The radiometric data were normalized to 400 feet terrain clearance, and are presented in the form of computer listings on microfiche and as stacked profile plots. Profile plots are contained in Volume II of this report. A geologic interpretation of the radiometric and magnetic data is included as part of this report

  9. TERRAIN, WINSTON COUNTY, ALABAMA USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  10. News Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

    Science.gov (United States)

    2011-01-01

    Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

  11. Winston Churchill : "Tormihoiatus". Kapitulatsioonijuubelite aegu / Henno Rajandi

    Index Scriptorium Estoniae

    Rajandi, Henno

    2002-01-01

    "Tormihoiatus" lk. 96-105, Kapitulatsioonijuubelite aegu lk. 105-110. Järelsõna raamatule: Churchill, W. Tormihoiatus. Tallinn : Varrak, 1995 ja sissejuhatav artikkel W. Churchilli memuaaridele "Bordeaux' relvarahu" ajakirjas "Looming", 1990, nr. 6

  12. Winston Churchill Memorial Trust Fellowship Report

    Science.gov (United States)

    Bramsen, Neil

    2014-01-01

    In March and April 2014, the author travelled overseas on a 2013 Churchill Fellowship to study education programs that successfully engage and enthuse primary and middle school students in maths, engineering and science (MES) or science, technology, engineering and maths (STEM) learning in schools, universities and institutions in the United…

  13. DCS Terrain Submission for Winston County, AL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  14. BASEMAP, WINSTON COUNTY AND INCORPORATED AREAS, ALABAMA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  15. Hearings Before the Special Subcommittee on Education of the Committee on Education and Labor, House of Representatives, Ninety-third Congress, First Session on H.R. 1144, H.R. 2994, H.R. 7261, H.R. 9065, H.R. 9960, H.R. 10027, H.R. 11658, and S. 1418. Bills to Provide Grants to Eisenhower College, Deganawidah-Quetzalcoatl University, the Sam Rayburn Library, the Winston Churchill Memorial Library, and the Hoover Institution on War, Revolution, and Peace.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    This document presents hearings before the special subcommittee on Education of the Committee on Education and Labor, House of Representatives, 93rd Congress concerning the provision of grants to Eisenhower College, Deganawidah-Quetzalcoatl University, the Sam Rayburn Library, the Winston Churchill Library, and the Hoover Institute on War,…

  16. Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

    Science.gov (United States)

    Vale, J A; Scadding, J W

    2017-12-01

    This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

  17. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, Winston COUNTY, AL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  18. Jón Þ. Þór: Winston S. Churchill ævisaga

    Directory of Open Access Journals (Sweden)

    Pétur Berg Matthíasson

    2014-12-01

    Full Text Available Í umsögn gagnrýnenda kemur meðal annars eftirfarandi fram: Það felast mörg tækifæri í svona bókum og maður getur séð fyrir sér heilan bókaflokk í þessum stíl. Það er hins vegar ljóst að þekking höfundar og ástríða á viðfangsefninu skilar bók sem allir ættu að lesa sem einhvern áhuga hafa á sögu og stjórnmálum.

  19. "My Grandfather Slammed the Door in Winston Churchill's Face!" Using Family History to Provoke Rigorous Enquiry

    Science.gov (United States)

    Barrett, Paul

    2011-01-01

    The idea of using "little stories" to illuminate the "big pictures" of the past was creatively explored in "Teaching History 107," which offered teachers a wealth of detailed vignettes with which to kindle young people's interest and illuminate major historical events. Paul Barrett builds on the ideas explored in that…

  20. The Human Relations Class at Sir Winston Churchill Secondary School. Research Report.

    Science.gov (United States)

    Gilbert, Katherine J.

    Human Relations was a program offered to Grade 10 students at Churchill Secondary School during the 1971-72 school year in lieu of four courses. The emphasis of the program was on the development of students as people who were more aware of themselves, of other people, and of the environment. The class took part in a variety of activities during…

  1. In Carthage ruins: the illness of Sir Winston Churchill at Carthage, December 1943.

    Science.gov (United States)

    Vale, J A; Scadding, J W

    2017-09-01

    This paper reviews Churchill's illness in Carthage in December 1943. It was characterised by fever that lasted 6 days, left lower lobe pneumonia and two episodes of atrial fibrillation. He was managed in a private villa by Lord Moran, his personal physician, with the assistance of two nurses and the expert advice of colleagues. Sulphadiazine and digitalis leaf were prescribed and Churchill recovered. It is remarkable that, despite the severity of his illness, he continued to direct the affairs of State from his bed.

  2. Did Winston Churchill suffer a myocardial infarction in the White House at Christmas 1941?

    Science.gov (United States)

    Vale, J Allister; Scadding, John W

    2017-12-01

    While staying in the White House over Christmas 1941, Churchill developed chest pain on trying to open a window in his bedroom. Sir Charles Wilson, his personal physician, diagnosed a 'heart attack' (myocardial infarction). Wilson, for political and personal reasons, decided not to inform his patient of the diagnosis or obtain assistance from US medical colleagues. On Churchill's return to London, Wilson sought a second opinion from Dr John Parkinson who did not support the diagnosis of coronary thrombosis (myocardial infarction) and reassured Churchill accordingly.

  3. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, WINSTON COUNTY, ALABAMA AND INCORPORATED AREAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  4. From hyperons to applied optics: open-quotes Winston Conesclose quotes during and after ZGS era

    International Nuclear Information System (INIS)

    Swallow, E.C.

    1994-01-01

    This paper discusses developments in light collection which had their origin in efforts to construct high performance gas Cerenkov detectors for precision studies of hyperon beta decays at the ZGS. The resulting devices, know generally as open-quotes compound parabolic concentrators,close quotes have found applications ranging from nuclear and particle physics experiments to solar energy concentration, instrument illumination, and understanding the optics of visual receptors. Interest in these devices and the ideas underlying them stimulated the development of a substantial new subfield of physics: nonimaging optics. This progression provides an excellent example of some ways in which unanticipated - and often unanticipatable - applied science and open-quotes practicalclose quotes devices naturally emerge from first-rate basic science. The characteristics of this process suggest that the term open-quotes spinoffclose quotes commonly used to denote it is misleading and in need of replacement

  5. CAPRELA (Cancer Prevention for Latinas): findings of a pilot study in Winston-Salem, Forsyth County.

    Science.gov (United States)

    Koval, Alejandra E; Riganti, Alicia Alemán; Foley, Kristie Long

    2006-01-01

    To evaluate knowledge and attitudes that affect cervical and breast cancer screening among uninsured Hispanic women. Cross-sectional, descriptive study of uninsured Latino women in Forsyth County, North Carolina. A convenience sample of Hispanic women who immigrated to the United States within the last ten years, primarily from Mexico (N = 70). Two trained lay health advisors (promotoras) administered in-person, structured surveys to 70 women in the community. All interviews were conducted in Spanish. Additionally two focus groups were conducted in Spanish to elucidate cultural beliefs and barriers to cancer screening not otherwise captured in the standardized surveys. Quantitative data were analyzed using logistic regression analysis. Qualitative data were transcribed and analyzed using a multi-step framework approach to identify and validate themes. Of 70 women, 42 (60%) reported a Pap smear within the last year; 26 (37%) reported two exams within the past three years. Among women aged 40 and older, 10 of 18 (56%) reported ever having a mammogram. Being married (OR = 4.05, CI 1.07-15.25) and having the same healthcare provider (OR 5.64, CI 1.04-30.56) predicted better Pap smear screening in multivariate analyses. Limited knowledge about breast cancer and needing an interpreter to communicate reduced the likelihood that women received a mammogram. Qualitative results indicated that women had poor prior experiences with Pap smears, held several misconceptions about cancer etiology and risk factors, and expressed distinct gender roles for Latina women and men that may affect healthcare utilization. Screening rates for cervical and breast cancer are low among uninsured Latina women. Therefore, community and clinic-based interventions are needed to improve underutilization of and satisfaction with cancer screening practices among uninsured Latina women.

  6. Implementation of an automated assessment system of the Winston-Lutz test based on the transformed generalized Hough; Implementacion de un sistema de evaluacion automatizada del test de Winston-Lutz basado en la transformada generalizada de Hough

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Viera Cueto, J. A.; Moreno Saiz, C.; Benitez Villegas, E. M.; Fernandez Canadillas, M. J.; Caballero Lucena, E.; Cantero Carrillo, M.

    2013-07-01

    It has implemented a software tool based on the generalized Hough transform to automate the evaluation of test WL This method provides a quantitative evaluation of the test. It also eliminates the subjectivity of the evaluator which is an uncertainty of 0.3 mm. (Author)

  7. Experiential Metafunctional Analysis of Winston S. Churchill's "Speech on Hitler's Invasion of the U.S.S.R."

    Science.gov (United States)

    Liping, Chen

    2014-01-01

    According to Halliday, it is language that enables human beings to form the impression of experience, which consists of "goings-on"--happening, doing, sensing, meaning and being and becoming, either internally and externally. This is the experiential metafunction. With the focus on Transitivity, a political discourse has been studied…

  8. 76 FR 21034 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-04-14

    ... Carolina. The workers are engaged in employment related to the production of desktop computers. The notice was published in the Federal Register on April 23, 2010 (75 FR 21361). The notices were amended on.... The notices were published in the Federal Register on April 19, 2010 (75 FR 20385), September 13, 2010...

  9. 75 FR 56564 - Dell Products LP, Winston-Salem (WS-1) Division Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-16

    ... Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR 21361). The notice was... notice was published in the Federal Register on April 19, 2010 (75 FR 20385). At the request of the State... engaged in employment related to the production of desktop computers. New information shows that workers...

  10. 75 FR 57505 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-21

    ... Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR 21361). The notice was... notice was published in the Federal Register on April 19, 2010 (75 FR 20385) At the request of the State... engaged in employment related to the production of desktop computers. New information shows that workers...

  11. 75 FR 55614 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-09-13

    ... Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR 21361). The notice was... notice was published in the Federal Register on April 19, 2010 (75 FR 20385) At the request of the State... engaged in employment related to the production of desktop computers. New information shows that workers...

  12. Studies in Teaching. 1995 Research Digest. Papers Presented at the Annual Research Forum (Winston-Salem, North Carolina, December 1995).

    Science.gov (United States)

    McCoy, Leah P., Ed.

    This is a collection of papers reporting student research projects at the Annual Research Forum, Department of Education, Wake Forest University (North Carolina). They include: "Student Interest in Studying World History in Relation to Current Events" (Conan Arthur); "Perceptions of High School Student Athletes and Athletics"…

  13. 76 FR 24474 - Adequacy Status of the Greensboro/Winston-Salem/Highpoint North Carolina 1997 Annual PM2.5

    Science.gov (United States)

    2011-05-02

    ... INFORMATION CONTACT: Dianna B. Smith, Environmental Scientist, U.S. Environmental Protection Agency, Region 4.../transp.htm (once there, click on the ``Transportation Conformity'' text icon, then look for ``Adequacy.../stateresources/index.htm , (once there, click ``Transportation Conformity'' text icon, then look for ``Adequacy...

  14. Studies in Teaching 1999 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 1999).

    Science.gov (United States)

    McCoy, Leah P., Ed.

    This publication presents a collection of research projects presented at the Annual Research Forum at Wake Forest University: "The Use of Group Work as an Effective Teaching Technique in Lower Level Spanish Classes" (James Blackburn); "What Are the Real Factors behind Student Motivation?" (Matthew Grey Burdick); "Can…

  15. Understanding the Anti-Access and Area Denial Threat: An Army Perspective

    Science.gov (United States)

    2015-05-21

    65Van Tol, et al, 32-40. 66Eric V. Larson, Derek Eaton, Paul Elrick, Theodore Karasik, Robert Klein , Sherrill Lingel, Brian Nichiporuk, Robert Uy...Davis, Lynn E., Stacie L. Pettyjohn, Melanie W. Sisson, Stephen M. Worman, and Michael J. McNerney. US Overseas Military Presence: What are the...Robert Klein , Sherrill Lingel, Brian Nichiporuk, Robert Uy, and John Zavadil. Assuring Access in Key Strategic Regions: Toward a Long-Term Strategy

  16. How Did Winston S. Churchill’s Experience as a Prisoner of War during the Boer War Affect His Leadership Style and Career?

    Science.gov (United States)

    2011-06-10

    Churchill, in typical fashion , did not have the finances to support either polo or hunting activities that early in his career. Thus, Churchill...leadership as the other two Boer republics and consequently the government went bankrupt. The British in typical fashion dispatched an emissary...195Ibid. 196Ibid. 197Donald Featherstone, Victorian Colonial Warfare Africa (London: Cassell Books, 1992

  17. A few cubic centimetres inside your skull: a interpretação dos sonhos de Winston Smith em Nineteen eighty-four, de George Orwell

    OpenAIRE

    Stefaisk, Stéfanie Alves

    2015-01-01

    Aliando Nineteen Eighty-Four, de George Orwell, e A Interpretação dos Sonhos, de Sigmund Freud, esta dissertação pretende interpretar os sonhos da personagem principal da obra de George Orwell para, assim, compreender os mecanismos de repressão da personagem, suas neuroses, traumas, fobias, anseios e desejos, e tentar perceber a fundo quem ele, no seu mais profundo inconsciente, realmente é. Analisando sete sonhos relatados pela personagem durante a narrativa, pretendo aplicar a metodologi...

  18. Medline Plus

    Full Text Available ... Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 7/ ... 2014) Percutaneous Placement of a Pulmonary Valve (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 12/ ...

  19. 78 FR 35874 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-06-14

    ... proposed for addition to the Procurement List for production by the nonprofit agencies listed: Products... Cleaner NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC Contracting Activity: Defense...

  20. Medline Plus

    Full Text Available ... Minimally Invasive, Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, ... Minimally Invasive, Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, ...

  1. Proceedings of Symposium on Energy Engineering in the 21st Century (SEE 2000). Volume Two

    Science.gov (United States)

    2000-01-13

    Nonimaging optics (Welford, Winston 1989) offer the possiblity to design Fresnel lenses as stationary concentrators with low...by Winston (1974), refined by Rabl (1976). A book named ’The Optics of Nonimaging Concentrators ’ by Welford and Winston (1978), later enlarged as...into English in Applied Solar Energy 19, 6, 36-39 24. W. T. Welford, R. Winston (1978) The Optics of Nonimaging Concentrators , New York 25. W.

  2. NF-kappaB Activity in Macrophages Determines Metastatic Potential of Breast Tumor Cells

    Science.gov (United States)

    2011-08-01

    about the relatively low number of mice in the control group so we decided to generate additional mice to increase the numbers in each group (Second...mammary epithelium increases tumor latency and decreases tumor burden. Oncogene 2010, In press. 10. Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T...littermate controls (Fig. 5E, 5G ). These differences were consistent with defects in saccular airway branching morphogenesis. The lack of effect in mice

  3. Net-Centric Sustainment and Operational Reach on the Modern Battlefield

    Science.gov (United States)

    2012-05-17

    Halliday, Marc L. Robbins , and Kenneth J. Girardini. "Sustainment of Army Forces in Operation Iraqi Freedom: Battlefield Logistics and Effects on Operations... Robbins , Kenneth J. Girardini, Rick Eden, John M. Halliday, and Jeffrey Angers. "Operation Iraqi Freedom: Major Findings and Recommendations...Timothy P. Williams, Tony R. Sherrill, Amy R. McGrath, Morris G. Hayes, Antoniette C. McGrady, and John M. Sheckler. "Logistics Command and Control

  4. 78 FR 73503 - Procurement List Additions and Deletions

    Science.gov (United States)

    2013-12-06

    ... by the General Services Administration. NSN: MR 376--Resealable Bags, Holiday, 6.5'' x 5.875''. NSN..., Holiday, 24PC. NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC. Contracting Activity... disabilities, and deletes a product and services from the Procurement List previously furnished by such...

  5. 75 FR 78976 - Procurement List Proposed Addition and Deletions

    Science.gov (United States)

    2010-12-17

    ... NSN: 7510-01-555-6167--Inkjet printer cartridge NPA: Alabama Industries for the Blind, Talladega, AL.../Location: Eyewear Prescription Service, Phoenix Indian Medical Center, 4212 N. 16th Street, Phoenix, AZ. NPA: Winston-Salem Industries for the Blind, Winston-Salem, NC. Contracting Activity: Health and Human...

  6. 76 FR 9555 - Procurement List; Additions and Deletions

    Science.gov (United States)

    2011-02-18

    ...-8067--Inkjet printer cartridge. NPA: Alabama Industries for the Blind, Talladega, AL. Contracting... Services Administration, New York, NY. Service Service Type/Location: Eyewear Prescription Service...: Winston-Salem Industries for the Blind, Inc., Winston- Salem, NC. Contracting Activity: Department of...

  7. Improved Conceptual Models Methodology (ICoMM) for Validation of Non-Observable Systems

    Science.gov (United States)

    2015-12-01

    28 3. The Waterfall Model ...29 Figure 9. The Waterfall Model ..................................................................................30 Figure 10. The Spiral...the elements are in compliance and meet the stakeholders’ satisfaction. 30 3. The Waterfall Model The waterfall model developed by Dr. Winston W

  8. Churchill, Moran and the struggle for survival.

    Science.gov (United States)

    Beasley, A W

    2010-12-01

    This paper examines the association between Winston Churchill and Charles McMoran Wilson, later Lord Moran, who was made personal physician to Churchill in 1940 at the instigation of the Cabinet when Churchill became prime minister of wartime Britain.

  9. Maailmavaatest / Mart Laar

    Index Scriptorium Estoniae

    Laar, Mart, 1960-

    2008-01-01

    Autori hinnangul vajab Euroopa konservatiivset poliitikat, mis julgeb lähtuda selgetest põhimõtetest ning väärtustest. Sarnastest põhimõtetest on varem juhindunud Winston Churchill, Konrad Adenauer ja Margaret Thatcher

  10. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 1/15/2009) Pituitary Tumors Transnasal Endoscopic ... Surgical Removal of the Thyroid Gland (Baptist Health South Florida, Miami, FL, 2/01/ ...

  11. Medline Plus

    Full Text Available ... Hospital, Greenville, SC, 6/14/2013) Brain and Nerves Back Pain SI (Sacroiliac) Fusion Surgery (Broward Health ... Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston-Salem, NC, ...

  12. Empowering Minority Communities with Health Information - WSSU

    Energy Technology Data Exchange (ETDEWEB)

    McMurray, L. and W. Templin-Branner

    2010-11-10

    Environmental health focus with training conducted as part of the United Negro College Fund Special Programs Corporation/National Library of Medicine HBCU ACCESS Project at Winston-Salem State University, NC on November 10, 2010.

  13. New Methods for Design and Computation of Freeform Optics

    Science.gov (United States)

    2015-07-09

    338, Springer-Verlag Berlin Heidelberg, 2009. [18] R. Winston, J. C. Miñano, and P. Beńıtez, with contributions by N. Shatz and J. Bortz, Nonimaging Optics, Elsevier Academic Press, Amsterdam, 2005. 8

  14. 76 FR 11781 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2011-03-03

    ... Bank, both of Hazel Green, Alabama. 3. P. Byron DeFoor, Ooltewah, Tennessee, and Winston A. Porter... indirectly acquire voting shares of Northside Bank, both of Adairsville, Georgia. 4. Michael Hull Erdman...

  15. 77 FR 5308 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2012-02-02

    ... ALBERT MAYER CONNOLLY WINSTON COOKSON GORDON POWER COONEY JOHN CUBAUD NICOLAS EDGARD CUDDY DAVID R... TAKEUCHI ERIKA TAN AH-SWAT TAN YEW KHUAN TANG MISI TANNER DAVID A TANNER JACQUELINE........ A TAUSCH HENRI...

  16. Chasing U-Boats and Hunting Insurgents: Lessons from an Underhand Way of War

    National Research Council Canada - National Science Library

    Breemer, Jan S

    2006-01-01

    .... Winston Churchill, then the Royal Navy's political head, was not willing to go quite that far, yet at one point during World War I, he ordered that captured U-boat crews be treated as criminals, not prisoners of war...

  17. Medline Plus

    Full Text Available ... Forest University Baptist Medical Center, Winston-Salem, NC, 12/16/13) Transesophageal Echocardiogram (TEE) (Shawnee Mission Medical ... Broward Health Medical Center, Fort Lauderdale, FL, 5/12/2014) Total Ankle Replacement (Doctors Hospital, Coral Gables, ...

  18. 78 FR 42975 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Science.gov (United States)

    2013-07-18

    ..., Dietikon, SWITZERLAND; Koyo Electronics Industries Co., Ltd.; Tokyo, JAPAN; vMonitor, LLC, Abu Dhabi... to this venture. Also, Office FA.com Co., Ltd., Tochigi, JAPAN; and Salem Automation Inc., Winston...

  19. Medline Plus

    Full Text Available ... Mission Medical Center, Merriam, KS, 10/17/2012) Liver Cancer Segment V Liver Resection (University of Arizona ... Medical Center, Winston-Salem, NC, 1/15/2009) Liver Cancer Segment V Liver Resection (University of Arizona ...

  20. Medline Plus

    Full Text Available ... Winston-Salem, NC, 09/17/2015) Kidneys and Urinary System Kidney Cancer Robot Assisted Partial Nephrectomy Using ... Norfolk General Hospital, Norfolk, VA, 3/25/2009) Urinary Incontinence Advanced Procedures in Male Incontinence: The Male ...

  1. 77 FR 65365 - Procurement List; Additions

    Science.gov (United States)

    2012-10-26

    ..., TX Eyewear NSN: 6650-00-NIB-0009--Single Vision, Plastic, Clear NSN: 6650-00-NIB-0010--Flat Top 28... Administration, Department of Veterans Affairs, Pittsburgh PA. NPA: Winston-Salem Industries for the Blind, Inc...

  2. A Bridge Over Troubled Waters: The Vital Role of Intelligence Sharing in Shaping the Anglo-American "Special Relationship"

    National Research Council Canada - National Science Library

    Clark, David B

    2008-01-01

    Speaking to an American audience in 1946, Winston Churchill articulated the British desire for a special relationship with America, coining a term which has continued to define the shifting vagaries...

  3. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, ... Erectile Dysfunction Simultaneous Inflatable Penile Prosthesis (IPP) and Male Sling Placement: Aiding in a Faster Return to ...

  4. Supermani esiisa / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Anglosaksi eepose "Beowulf" alusel on valminud samanimeline USA seiklusfilm : stsenaristid Neil Gaiman, Roger Avary : režissöör Robert Zemeckis : osades Anthony Hopkins, Angelina Jolie, Ray Winstone

  5. "Beowulf" : Hollywood seikleb pimedas keskajas / Riho Laurisaar

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2007-01-01

    Anglosaksi eeposest "Beowulf", mille alusel on valminud USA seiklusfilm, millest suur osa on loodud arvutigraafika abil ( stsenarist Neil Gaiman, režissöör Robert Zemeckis, osades Anthony Hopkins, Angelina Jolie, Ray Winstone)

  6. Medline Plus

    Full Text Available ... Mission Medical Center, Merriam, KS, 05/04/2012) Kidney Cancer Robot Assisted Partial Nephrectomy Using Fluorescence (Shawnee ... Medical Center, Winston-Salem, NC, 09/17/2015) Kidneys and Urinary System Kidney Cancer Robot Assisted Partial ...

  7. Raamaturappija / Karl Martin Sinijärv

    Index Scriptorium Estoniae

    Sinijärv, Karl Martin, 1971-

    1996-01-01

    Tubli lapse tunnikell / Tekst Leelo Tunglalt; Groom, Winston. Gump & Co; Higgins, Jack. Soolo; Winter, Arno. Sodila ehk abiks tagumises pingis igavlejale; Murphy, Warren ja Shapir, Richard. Remo Special - Vastulöök

  8. Medline Plus

    Full Text Available ... Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ... Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ...

  9. Long Term Follow up of the Delayed Effects of Acute Radiation Exposure in Primates

    Science.gov (United States)

    2017-10-01

    Mark Cline, DVM, PhD CONTRACTING ORGANIZATION: Wake Forest University Health Sciences Winston Salem, NC 27157 REPORT DATE: October 2017 TYPE OF...ORGANIZATION NAME(S) AND ADDRESS(ES) . AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Wake Forest University Health Sciences
 Winston, NC...personnel; acquisition of NHP subjects for the prospective cohort; pre-irradation physical examinations, imaging, and blood sampling for all projects

  10. Cultural Arrogance and Blind Faith: The Strategic Origins of the Dardanelles Campaign

    Science.gov (United States)

    2015-05-21

    Finally, my thanks to my reviewers; Paul, Lee, Chris , and Cassie, who all had drafts inflicted upon them at varying stages of maturity (the drafts’ not...Churchill, vol. 3, pt. 1, 544. 95 Quoted in: T. Higgins , Winston Churchill and the Dardanelles (London: Heinemann, 1963), 144. 96 CAB 42, 42/1/42...Praeger, 2010). 177 Quoted in: Higgins , Winston Churchill and the Dardanelles. 140. 178 Quoted in: Marder, Dreadnought to Scapa Flow, 213. 179

  11. A Wave Theory for Non-Imaging Concentrators

    Science.gov (United States)

    1992-04-01

    the radiance function over the z = 0 plane, as defined by Walther (W), 6 W. T. Welford and R. Winston, High Collection Nonimaging Optics , Academic...Laurel, Maryland 2072&-6099 REFERENCES IW. T. Welford and R. Winston, High Collection Nonimaging Optics , Academic Press, New York (1989). 2 W. Welford and...stationary optical system. For light from a quasi-homogeneous source, this expression can be somewhat simplified by an approximatior. It is shown that the

  12. New Concepts in Ionospheric Modification

    Science.gov (United States)

    1987-04-01

    lasers, Phys. Fluids, 26, 1688-1692, 1986. Welford, W.T., and R. Winston , The Optics of Nonimaging Concentrators , 200 pp., Academic, New York, 1978...tantalum target/reflector assembly. We now use the following relationship, which follows from the conservation of optical 6tendue [ Welford and Winston ...of existing data obtained during thruster firings on STS-3 and Spacelab-2. (’orisiderable optical and plasma data are immediately available for study

  13. Multiaperture Optical System Research.

    Science.gov (United States)

    1987-11-06

    pp. 179-185 (1965). 6. Welford, W. T. and Winston , R., The Optics of Nonimaging Concentrators , P. 3, Academic Press, New York (1978). 7. Schneider, R...Welford and Winston investigated it was a possible concentrator for solar energy. They came up with the "ideal concentrator ", which has walls shaped...MULTIAPZRTURE OPTICAL SYSTEM RESEARCH ." Office of Naval Research Contract Number N00014-85-C-0862 . FINAL REPORT by RTS LABORATORIES, INC. 1663

  14. Summer Faculty Research Program (SFRP) (1992). Volume 1. Program Management Report.

    Science.gov (United States)

    1992-12-01

    for expenses (i.e., for their to/from trip, privately owned automobile mileage at ($0.25) per mile). A rental-car’s cost is not an authorized...Professor SPECIALTY: Psychology Dept of Social Sciences LABORATORY: AL/ HRM Winston-Salem State University Winston-Salem, NC 27110 Robert J. Turnbull DEGREE...Psychology Dept of Psychology LABORATORY: AL/ HRM Columbus, OH 43210-1222 Ronald L. O(l{svor DEGREE: "S Ohio State University SPECIALTY: Electrical

  15. Using enteric pathogens to assess sources of fecal contamination in the Silurian Dolomite Aquifer: Preliminary results

    Science.gov (United States)

    Muldoon, Maureen A; Borchardt, Mark A.; Spencer, Susan K.; Hunt, Randall J.; Owens, David

    2018-01-01

    The fractured Silurian dolomite aquifer is an important, but vulnerable, source of drinking water in northeast Wisconsin (Sherrill in Geology and ground water in Door County, Wisconsin, with emphasis on contamination potential in the Silurian dolomite, 1978; Bradbury and Muldoon in Hydrogeology and groundwater monitoring of fractured dolomite in the Upper Door Priority Watershed, Door County, Wisconsin, 1992; Muldoon and Bradbury in Assessing seasonal variations in recharge and water quality in the Silurian aquifer in areas with thicker soil cover. p 45, 2010). Areas underlain by the Silurian dolomite aquifer are extremely vulnerable to groundwater contamination from various land-use activities, especially the disposal of human wastewater and dairy manure. Currently there is no consensus as to which source of wastewater generates the greater impact to the aquifer.

  16. A dream come true: being President of ASHRM.

    Science.gov (United States)

    Oppenberg, Andrew A

    2014-01-01

    During our 33rd Annual Conference of the American Society for Healthcare Risk Management, I had the absolute honor and privilege to thank our 2013 ASHRM board and staff along with the ASHRM membership. On behalf of the membership I extended heartfelt thanks for a job well done to our retiring board members, friends, and colleagues: Faye Shepherd, Ellen Grady-Venditti, Michael Midgley, and Immediate Past President Mary Anne Hilliard. Together, we welcomed 2014 ASHRM board members and witnessed the oath of office to Hala Helm, David Sine, and Sherrill Peters, along with President-Elect Ellen Grady-Venditti and our 2014 President Jacque Mitchell. © 2014 American Society for Healthcare Risk Management of the American Hospital Association.

  17. Inclusion of students with special education needs in physical education

    Directory of Open Access Journals (Sweden)

    Martin Kudláček

    2010-01-01

    Full Text Available The purpose of this article is to present phenomena of inclusive physical education from the point of view of needs of students with SEN, teachers from the point of view of support and university PE teacher preparation programs (PETE.Inclusion of students with special educational needs (SEN in physical education is in Czech Republic still marginal topic, although issues related to inclusive physical education are among key challenges of students with SEN, their teachers, parents and university departments preparing prospective teachers. In the area of support in inclusive PE we present the model of support in inclusive PE (Sherrill, 2004; Kudláček & Ješina, 2008 and in the area of PETE we present of key outcomes of project EIPET (Theoretical knowledge, competence and skills framework.

  18. Appointing silver and bronze standards for noncovalent interactions: A comparison of spin-component-scaled (SCS), explicitly correlated (F12), and specialized wavefunction approaches

    International Nuclear Information System (INIS)

    Burns, Lori A.; Marshall, Michael S.; Sherrill, C. David

    2014-01-01

    A systematic examination of noncovalent interactions as modeled by wavefunction theory is presented in comparison to gold-standard quality benchmarks available for 345 interaction energies of 49 bimolecular complexes. Quantum chemical techniques examined include spin-component-scaling (SCS) variations on second-order perturbation theory (MP2) [SCS, SCS(N), SCS(MI)] and coupled cluster singles and doubles (CCSD) [SCS, SCS(MI)]; also, method combinations designed to improve dispersion contacts [DW-MP2, MP2C, MP2.5, DW-CCSD(T)-F12]; where available, explicitly correlated (F12) counterparts are also considered. Dunning basis sets augmented by diffuse functions are employed for all accessible ζ-levels; truncations of the diffuse space are also considered. After examination of both accuracy and performance for 394 model chemistries, SCS(MI)-MP2/cc-pVQZ can be recommended for general use, having good accuracy at low cost and no ill-effects such as imbalance between hydrogen-bonding and dispersion-dominated systems or non-parallelity across dissociation curves. Moreover, when benchmarking accuracy is desirable but gold-standard computations are unaffordable, this work recommends silver-standard [DW-CCSD(T**)-F12/aug-cc-pVDZ] and bronze-standard [MP2C-F12/aug-cc-pVDZ] model chemistries, which support accuracies of 0.05 and 0.16 kcal/mol and efficiencies of 97.3 and 5.5 h for adenine·thymine, respectively. Choice comparisons of wavefunction results with the best symmetry-adapted perturbation theory [T. M. Parker, L. A. Burns, R. M. Parrish, A. G. Ryno, and C. D. Sherrill, J. Chem. Phys. 140, 094106 (2014)] and density functional theory [L. A. Burns, Á. Vázquez-Mayagoitia, B. G. Sumpter, and C. D. Sherrill, J. Chem. Phys. 134, 084107 (2011)] methods previously studied for these databases are provided for readers' guidance

  19. Bereday and Hilker: Origins of the "Four Steps of Comparison" Model

    Science.gov (United States)

    Adick, Christel

    2018-01-01

    The article draws attention to the forgotten ancestry of the "four steps of comparison" model (description--interpretation--juxtaposition--comparison). Comparativists largely attribute this to George Z. F. Bereday [1964. "Comparative Method in Education." New York: Holt, Rinehart and Winston], but among German scholars, it is…

  20. Long term storage of bee semen – A six month assessment of cryopreserved semen quality using motility as an index

    Science.gov (United States)

    Bee (Apis mellifera Linn.) spermatozoa is known for its ability to remain viable for at the least two years within the spermatheca as attested to by the queens’ continued laying of fertile eggs without remating over two to three (Woyke 1960; Winston 1987). However, the semen collected from the dron...

  1. The E-Book Phenomenon: A Disruptive Technology

    Science.gov (United States)

    Wilson, T. D.

    2014-01-01

    Introduction: The e-book and its associated technology have emerged as a disruptive technology over the past ten years. The aim of this paper is to discuss some of the consequences of this development, based on the work of the e-books in Sweden research projects. Argument: To explain the impact of the e-book phenomenon we use Winston's theory of…

  2. Medline Plus

    Full Text Available ... Mission Medical Center, Merriam, KS, 10/17/2012) Liver Cancer Segment V Liver Resection (University of Arizona Medical ... Medical Center, Winston-Salem, NC, 1/15/2009) Liver Cancer Segment V Liver Resection (University of Arizona Medical ...

  3. Factors that influence Christmas tree sales

    Science.gov (United States)

    Thomas H. Pendleton; Lawrence D. Garrett

    1970-01-01

    An analysis of the metropolitan Christmas tree market in Winston-Salem, N. C., shows that to sell more trees, Christmas tree retailers should locate their lots on heavily traveled streets in business areas, have adequate parking facilities, advertise, and have attractive displays of trees. Retailers who follow these practices can expect to receive higher prices for...

  4. Structure of an urban Christmas tree market

    Science.gov (United States)

    Thomas H. Pendleton; Lawrence D. Garrett; Lawrence D. Garrett

    1973-01-01

    The retail Christmas tree market in Winston-Salem, N.C., was studied 3 years. Types of retailers and their sales are described. Best sales were made by dealers who had lots on heavily traveled streets in business districts, had ample parking facilities, advertised, and displayed their trees well.

  5. Kolm haiget vanameest jagasid omavahel maailma / Jaan Franclin Perlitz

    Index Scriptorium Estoniae

    Perlitz, Jaan Franclin

    2007-01-01

    4. veebruaril 1945 istusid Jaltas Suurbritannia peaminister Sir Winston Churchill, USA president Franklin Delano Roosevelt ning NSV Liidu riigipea Jossif Stalin, et muu hulgas arutleda, kuidas Euroopa kaart pärast Teise maailmasõja lõppu välja peaks nägema

  6. Documents Related to Churchill and FDR. The Constitution Community: The Great Depression and World War II (1929-1945).

    Science.gov (United States)

    Gray, Tom

    During World War II, a close friendship and excellent working relations developed between President Franklin D. Roosevelt (FDR) and Prime Minister Winston Churchill that were crucial in the establishment of a unified effort to deal with the Axis powers. In early 1941, FDR began the long-term correspondence that developed into a close working…

  7. Isaac Newton

    CERN Document Server

    Westfall, Richard S

    2007-01-01

    Definitive, concise, and very interesting... From William Shakespeare to Winston Churchill, the Very Interesting People series provides authoritative bite-sized biographies of Britain's most fascinating historical figures - people whose influence and importance have stood the test of time. Each book in the series is based upon the biographical entry from the world-famous Oxford Dictionary of National Biography. -

  8. 76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

    Science.gov (United States)

    2011-05-11

    ... Logistics Division, Including On-Site Leased Workers From Prologistix, Including Workers Whose Unemployment..., applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site leased workers from... workers employed at CEVA Freight, LLC, Dell Logistics Division, Winston-Salem, North Carolina who were...

  9. Medline Plus

    Full Text Available ... Roosevelt Hospital, New York, NY, 1/04/2012) Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ... Center, Winston-Salem, NC, 09/17/2015) Seniors Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ...

  10. 78 FR 37118 - Approval and Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and...

    Science.gov (United States)

    2013-06-20

    ... the core maintenance area exists; c. alternative fuel vehicle programs to include compressed natural... Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and Winston-Salem Carbon Monoxide... (CO), showing continued attainment of the 8-hour CO national ambient air quality standard for the...

  11. Chopper GEN2 + Glyphosate efficacy for height classes of hardwood sprouts recolonizing six clearcut pine sites

    Science.gov (United States)

    Jimmie Yeiser; Andrew Ezell

    2015-01-01

    The purpose of this study was to assess sprout size as a determinant of subsequent control by a standard, single rate of imazapyr +glyphosate applied during site preparation. All study sites were in the hilly upper coastal plain of Mississippi (Winston or Oktibbeha Counties) or Louisiana (Sabine or Winn Parishes) and supported loblolly pine (Pinus taeda L.) plantations...

  12. 75 FR 4783 - Procurement List; Proposed Additions

    Science.gov (United States)

    2010-01-29

    ..., Winston-Salem, NC. LC Industries, 4500 Emperor Blvd., Durham, NC. Lions Services, Inc., 4600 North Tryon... for the Blind, 6918 Murray Street, Little Rock, AR. NPAs: National Industries for the Blind... Arkansas Lighthouse for the Blind, Little Rock, AR. Contracting Activity: Department of Homeland Security...

  13. The Nature of the Electron

    Science.gov (United States)

    Lincoln, Don

    2016-01-01

    Winston Churchill once said of Russia that it was a riddle wrapped in mystery inside an enigma. Were the British Bulldog a physicist, he might have been talking of something other than our Slavic comrades. He might have been talking about an electron. This article covers the more modern representations of the electron. A brief reminder of the…

  14. Why can't China clean up its act?

    NARCIS (Netherlands)

    P.P.M.A.R. Heugens (Pursey)

    2017-01-01

    textabstractWinston Churchill once described the Soviet Union as 'a riddle wrapped in a mystery inside an enigma.’ Modern China is a very different story. By definition, the workings of the world’s largest economy (by purchasing power parity) can’t really be hidden from view nearly as easily.

  15. Medline Plus

    Full Text Available ... Coral Springs, FL, 3/31/2014) Digestive System Bile Duct Cancer Diagnosing & Treating Digestive Tract Disorders Endoscopically (Wake ... Medical Center, Winston-Salem, NC, 1/15/2009) Bile Duct Diseases Diagnosing & Treating Digestive Tract Disorders Endoscopically (Wake ...

  16. Author Details

    African Journals Online (AJOL)

    Makanga, Winston Ominde. Vol 13, No 2 (2016) - Articles The Heimlich Valve for Pleural Cavity Drainage Abstract PDF. ISSN: 2523-0816. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

  17. The Heimlich Valve for Pleural Cavity Drainage

    African Journals Online (AJOL)

    The ANNALS of AFRICAN SURGERY | www.annalsofafricansurgery.com. The ANNALS of AFRICAN SURGERY. July 2016 Volume 13 Issue 2 45. The Heimlich Valve for Pleural Cavity Drainage. Winston Ominde Makanga1, Andrew Nyaoncha Nyangau2 , Benjamin Njoga Njihia3. 1. St Mary's Mission Hospital, Elementaita.

  18. Annals of African Surgery - Vol 13, No 2 (2016)

    African Journals Online (AJOL)

    The Heimlich Valve for Pleural Cavity Drainage · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Winston Ominde Makanga, Andrew Nyaoncha Nyangau, Benjamin Njoga Njihia. http://dx.doi.org/10.4314/aas.v13i2.2 ...

  19. 40 CFR 51.121 - Findings and requirements for submission of State implementation plan revisions relating to...

    Science.gov (United States)

    2010-07-01

    ... Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Virginia, West Virginia, and the...,406 New Jersey 96,876 New York 240,322 North Carolina 165,306 Ohio 249,541 Pennsylvania 257,928 Rhode..., Russell, St. Clair, Shelby, Sumter, Talladega, Tallapoosa, Tuscaloosa, Walker, and Winston. (C) [Reserved...

  20. MedlinePlus: Surgery Videos

    Science.gov (United States)

    ... Shawnee Mission, KS, 3/05/2014) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ... Winston-Salem, NC, 1/15/2009) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ...

  1. Medline Plus

    Full Text Available ... Shawnee Mission, KS, 3/05/2014) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ... Winston-Salem, NC, 1/15/2009) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ...

  2. Fulltext PDF

    Indian Academy of Sciences (India)

    Echoing Winston Churchill one is tempted to say – never before have so few from such a small country done so much affecting so many! In this issue of Resonance we honour Wigner's life and work. After the pioneering steps taken by Henri Poincaré and Albert. Einstein in emphasizing the importance of symmetry and invari ...

  3. representation without participation: an overview of local ...

    African Journals Online (AJOL)

    Admin

    One was the mentally-liberating impact of war- time experiences and propaganda on the colonial subjects. Particularly noteworthy in this respect was the third Clause of the Atlantic Charter by. Prime Minister Winston Churchill of Britain while explaining to the world why the Allied Forces were fighting the war against the Axis ...

  4. The Basket Girl, Limbe: Popular 116 Book review

    African Journals Online (AJOL)

    most beautiful woman of easy virtue [Rose]? The action sets into motion a series of reactions, discoveries of parentage, adoptions ... which appears to be an unlikely solution for a man in Winston's position. .... which his characters move. I found ...

  5. A Longitudinal Study of Chickering and Reisser's Vectors: Exploring Gender Differences and Implications for Refining the Theory

    Science.gov (United States)

    Foubert, John; Nixon, Monica; Sisson, V. Shamim; Barnes, Amy C.

    2005-01-01

    A racially mixed random sample of 247 students at a midsized public university in the Southeast completed the Student Development Task and Lifestyle Inventory at the beginning of their first year, beginning of their sophomore year, and end of their senior year (Winston, Miller & Prince, 1987). Results showed partial support of Chickering and…

  6. Chimamanda Ngozi Adichie's Half of a Yellow Sun : a symbolic ...

    African Journals Online (AJOL)

    ... rest of the world about this sarcastic fiasco. Sir Winston Churchill, the onetime British Prime Minister, refused presiding over the liquidation of the British empire, Biafra included, but Biafra succeeded in making a mockery of British's social sublimity and alienation in the person of Richard Churchill, the symbol of British fall.

  7. Developing Models to Forcast Sales of Natural Christmas Trees

    Science.gov (United States)

    Lawrence D. Garrett; Thomas H. Pendleton

    1977-01-01

    A study of practices for marketing Christmas trees in Winston-Salem, North Carolina, and Denver, Colorado, revealed that such factors as retail lot competition, tree price, consumer traffic, and consumer income were very important in determining a particular retailer's sales. Analyses of 4 years of market data were used in developing regression models for...

  8. Medline Plus

    Full Text Available ... Patient Quality-of-Life (Washington University School of Medicine in St. Louis, St. Louis, MO, 05/11/2011) Lungs and Breathing Lung Cancer Robotic-Assisted Surgery: Lung Resection (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 2/ ...

  9. Romans 12 Motivational Gifts and College Professors: Implications for Job Satisfaction and Person-Job Fit

    Science.gov (United States)

    Tomlinson, Jon C.; Winston, Bruce E.

    2011-01-01

    This study builds on earlier work by DellaVecchio and Winston (2004) and McPherson (2008). They addressed the seven motivational gifts Paul wrote about in Romans 12:3-8 as a means for addressing job satisfaction and person-job fit among college professors. Using a snowball sampling method, 89 college professors completed the online survey…

  10. U.S. Foreign Policy and the UN System. Special Bibliography Series.

    Science.gov (United States)

    1995-10-01

    34Operation Provide Comfort: A Case Study in Humanitarian Relief and Foreign Assistance" Air Force Law Review 37 (1994): 225-38. 21 Mendez , Ruben 1... Carole Forced Out: The Agony of the Refuzee in Our Time. New York Random, 1989 (IIV 640 .K57 1989) 3( Langley, Winston E., ed. Human Rights: Sixtv Maior

  11. Pop / Mart Kuldkepp

    Index Scriptorium Estoniae

    Kuldkepp, Mart

    2008-01-01

    Heliplaatidest: James "Hey Ma", Kelder "Vikerkaar ja latimeeria", David Torn "Lars and the Real Girl. Music from the motion picture", Tanel Ruben "Kogutud rikkus", Neon Neon "Stainless Style", 3 Doors Down "3 Doors Down", Winston Tong "In a Manner Of Speaking (Best Of)", Witch "Paralyzed"

  12. 78 FR 54871 - Procurement List; Proposed Additions and Deletion

    Science.gov (United States)

    2013-09-06

    ...: GENERAL SERVICES ADMINISTRATION, NEW YORK, NY Holiday Themed Bags, Containers and Baking Cup-Picks Set NSN... 16 oz., 6PK NSN: MR 380--Set, Baking Cups and Picks, Holiday, 24PC NPA: Winston-Salem Industries for... General Services Administration NSN: 7520-00-NIB-0358--Kit, Mounting Board, GHS Information Center NSN...

  13. 78 FR 67129 - Procurement List; Additions

    Science.gov (United States)

    2013-11-08

    ...: Products NSN: MR 377--Socks, Holiday. NSN: MR 382--Duct Tape, Holiday Themed, Assorted Colors. NSN: MR 10635--Serving Platter, Heavy Duty, Raised Surface, Fall Themed, White. NPA: Winston-Salem Industries... Requirement as aggregated by the General Services Administration. NSN: 6645-00-NIB-0142--Clock, Wall, Quartz...

  14. The Grief Account: Dimensions of a Contemporary Bereavement Genre

    Science.gov (United States)

    Dennis, Michael Robert

    2008-01-01

    The genre of the grief account is identified to include published narratives of surviving grief. Thematic analysis of Andrew Holleran's (2006) "Grief: A Novel," Lolly Winston's (2004) "Good Grief: A Novel," Joan Didion's (2005) "The Year of Magical Thinking," and J. Canfield and M. V. Hansen's (2003) "Chicken Soup for the Grieving Soul: Stories…

  15. National Intelligence University’s Role in Interagency Research: Recommendations from the Intelligence Community

    Science.gov (United States)

    2013-01-01

    Structure, New York: Wiley, 1955. 3 J. S. Bruner and L. Postman, “On the Perception of Incongruity: A Paradigm,” Journal of Personality, Vol. 18...Bandura, A., Principles of Behavior Modification, New York: Holt, Rinehart and Winston, 1969. Bruner , J. S., and L. Postman, “On the Perception of

  16. 77 FR 77016 - Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets...

    Science.gov (United States)

    2012-12-31

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-69-2012] Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets); Rural Hall and Winston-Salem, North Carolina On August 20, 2012, the Piedmont Triad Partnership, grantee of FTZ 230, submitted a notification of...

  17. Bike Skills Training in PE Is Fun, Keeps Kids Safe

    Science.gov (United States)

    Wallace, Judi Lawson; Sutton, Nancy P.

    2015-01-01

    Incorporating bike skills into the elementary- and middle-school physical education curriculum encourages students to be physically active in a fun way while also learning bike safety skills. Winston-Salem's (NC) Safe Routes to School program demonstrates how collaboration with the public schools' health and physical education program can…

  18. 78 FR 45181 - Foreign-Trade Zone 230-Piedmont Triad Area, North Carolina, Authorization of Production Activity...

    Science.gov (United States)

    2013-07-26

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-31-2013] Foreign-Trade Zone 230--Piedmont Triad Area, North Carolina, Authorization of Production Activity, Oracle Flexible Packaging, Inc., (Foil-Backed Paperboard), Winston-Salem, North Carolina On March 25, 2013, the Piedmont Triad Partnership...

  19. Taking Care of Business: Bridging the Skills Gap

    Science.gov (United States)

    Gatewood, Algie

    2017-01-01

    This brief article describes how Alamance Community College, a mid-sized community college sandwiched between two of North Carolina's largest metropolitan markets in Raleigh-Durham and Greensboro-Winston-Salem, has developed several new study programs and initiatives to better service business and industry. Among other things, Almanac has…

  20. Medline Plus

    Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, Coral Springs, FL, 3/31/2014) Erectile Dysfunction Simultaneous Inflatable Penile Prosthesis (IPP) and Male Sling Placement: Aiding in a Faster Return to ...

  1. Rawls, Race, and Education: A Challenge to the Ideal/Nonideal Divide

    Science.gov (United States)

    Thompson, Winston C.

    2015-01-01

    In this essay, Winston C. Thompson questions the rigidity of the boundary between ideal and nonideal theory, suggesting a porosity that allows elements of both to be brought to bear upon educational issues in singularly incisive ways. In the service of this goal, Thompson challenges and extends John Rawls's theory of justice as fairness, bringing…

  2. From Pivot to Symmetry Integrating Africa in the Rebalance to Asia

    Science.gov (United States)

    2014-02-13

    http://www.wilsoncenter.org/sites/default/files/winston_lord_speech.pdf, (accessed 16 January 2014). 21 Hannah Arendt and Margaret Canovan, The...Foreign Affairs, vol.57, nr. 5 (Summer 1979), p. 975. Bibliography Arendt , Hannah , and Margaret Canovan. The Human Condition. Chicago

  3. Molluscan Evolutionary Development

    DEFF Research Database (Denmark)

    Wanninger, Andreas Wilhelm Georg; Koop, Damien; Moshel-Lynch, Sharon

    2008-01-01

    Brought together by Winston F. Ponder and David R. Lindberg, thirty-six experts on the evolution of the Mollusca provide an up-to-date review of its evolutionary history. The Mollusca are the second largest animal phylum and boast a fossil record of over 540 million years. They exhibit remarkable...

  4. Research Paper ISSN 0189-6016©2008

    African Journals Online (AJOL)

    African J. TradCAM

    It is also used for dry coughs and gastric ulcers (Winston, 2004). Recent research indicates Shatavari enhances immune function, increases corticosteroid production, and promotes cell regeneration (Rege et al., 1999). In Thailand the root is claimed as a galactagogue, antidysenteric, antipeptic, antipruritic, antirheumatic,.

  5. Analysis of Market Factors Associatedwith Sales of Cut Natural Christmas Trees

    Science.gov (United States)

    Lawrence D. Garrett

    1977-01-01

    A study of the market performance of natural Christmas tree retailers in Winston-Salem, North Carolins, revealed that success was strongly related to location in active retail shopping areas. Christmas tree retailers in shopping centers or areas high in retail sales sold more trees, received a higher average price, and had fewer trees left unsold than retailers in...

  6. Názory budoucích pedagogů na začlenění dětí s postižením do tělesné výchovy v Jihoafrické republice Attitudes of future physical educators toward teaching children with disabilities in physical education in the Republic of South Africa

    Directory of Open Access Journals (Sweden)

    Liz Bressan

    2007-02-01

    Full Text Available Jednou z bariér, týkající se začlenění dětí s postižením do tělesné výchovy, mohou být negativní postoje učitelů. Tyto postoje mohou pramenit z neznalosti nebo nedostatku zkušeností s dětmi s postižením. Pro překonání těchto bariér je nezbytné změnit postoje těch, kteří mají být prostředníky v inkluzi. Tripp a Sherrill (1991 opakovaně vyzdvihují význam postojů v aplikovaných pohybových aktivitách a jejich výzkumu. Teoreticky podložený výzkum o utváření postojů může stanovit rámec porozumění faktorům, které působí na vztah mezi postojem a chováním (Tripp & Sherrill, 1991. V rámci výzkumu postojů jsme upravili dotazník "Attitude Toward Teaching Individuals with Physical Disabilities in Physical Education" (ATIPDPE pro studenty oboru "sport science" na Universitě Stellenbosch v Jihoafrické republice. Do výzkumu bylo začleněno 60 studentů. Utvořili jsme dvě skupiny, ve kterých bylo 30 studentů se specializací trenérství osob se zdravotním postižením a 30 studentů bez této specializace. Porovnali jsme skupiny v komponentech teorie plánovaného jednání a výsledky ukázaly, že mezi postoji studentů v těchto dvou skupinách není statisticky významný rozdíl. The Republic of South Africa has undergone significant changes with regard to people with disabilities in the past number of years, which have also included changes in legislation and education. In the education of children with disabilities, inclusion is quite a new phenomenon. In order to prepare for inclusion, universities must focus on teacher preparation. Sherrill (1998 emphasised the role of attitudes in teacher preparation and therefore we have focused on the attitudes of university students toward inclusion. The aim of this study was to examine the differences in attitudes between two groups of students of the Department of Sport Science at the University of Stellenbosch in the Republic of South

  7. FACT light collection - solid light concentrators in Cherenkov Astronomy

    Energy Technology Data Exchange (ETDEWEB)

    Braun, Isabel [ETH Zurich, Institute for Particle Physics, CH-8093 Zurich (Switzerland); Collaboration: FACT-Collaboration

    2011-07-01

    Pixelized cameras of Imaging Atmospheric Cherenkov Telescopes use hollow light guides with reflective surfaces based on the Winston cone design. These cones minimize insensitive spaces between the photo sensors and shield the camera from stray background light by limiting the angular acceptance to the primary reflector area. FACT (First G-APD Cherenkov Telescope) will be the first IACT with Geiger-mode avalanche photodiodes as light sensors. Solid light concentrators complementing these sensors will be used instead of hollow Winston cones. We will present simulations and measurements of our light collector design, which was optimized for the requirements of the FACT telescope and detector, and discuss the specific differences to more traditional solutions.

  8. Desferrioxamine for Stimulation of Fracture Healing and Revascularization in a Bone Defect Model

    Science.gov (United States)

    2012-02-01

    cartilaginous tissue still present. DBM + L-DFO: Fracture gap less evident with more complete bone bridging with denser trabecular bone and less...fracture callus volume by micro-CT, and qualitative histology for callus tissue quality and vascularity in 5 groups (No implant, CS implant, DFO+CS...Weinhold, P. North Carolina Tissue Engineering and Regenerative Medicine Meeting, November 4, 2011; Winston Salem, NC. (presented) • Desferroxamine with

  9. Qualitative Case Study Guidelines

    Science.gov (United States)

    2013-11-01

    Introduction to Sociological Methods. 2nd ed. New York, McGraw-Hill 14. Denzin , N. K. and Lincoln , Y. S. (2011) The SAGE Handbook of Qualitative...The Art of Science. In: Denzin , N. K. and Lincoln , Y. S. (eds.) Handbook of Qualitative Research. Thousand Oaks, Sage 19. GAO (1990) Case Study...Rinehart & Winston 39. Stake, R. E. (1994) Case Studies. In: Denzin , N. K. and Lincoln , Y. S. (eds.) Handbook of Qualitative Research. Thousand Oaks, Sage

  10. A model of strategic marketing alliances for hospices: vertical, internal, osmotic alliances and the complete model.

    Science.gov (United States)

    Starnes, B J; Self, D R

    1999-01-01

    This article develops two previous research efforts. William J. Winston (1994, 1995) has proposed a set of strategies by which health care organizations can benefit from forging strategic alliances. Raadt and Self (1997) have proposed a classification model of alliances including horizontal, vertical, internal, and osmotic. In the second of two articles, this paper presents a model of vertical, internal, and osmotic alliances. Advantages and disadvantages of each are discussed. Finally, the complete alliance system model is presented.

  11. Endocrinological Responses to the Administration of Nicotine: Interactions with Drug Initiation, Conditioned Effects, and Conditions of Stress, Volume II

    Science.gov (United States)

    1984-01-07

    Benowitz, Kuyt and Jacob, 1982; Feyerabend S Russe l l , 1978). 273 10 Measurement of hematocrit was performed as follows: 1) after centrifugation of...Incentives, Washington, D.C.: Winston. Feyerabend , C. , & Russell, M. A. H. (1978). Effect of urinary pH and nicotine excretion rate can plasma...s Feyerabend , c. (1978). Cigarette smoking: A dependence on high-nicotine boll. Drug Metabolism Review, 8_, 29-57. Russell, M. A. H. , Wilson, C

  12. 7TH Annual Anesthesia and Critical Care Symposium (7th) Held in Paris (France) on 22-24 April 1994,

    Science.gov (United States)

    1994-09-30

    Amphitheatre Poincare DIMANCHE 24 AVRIL / SUNDAY APRIL 24th TRAUMATISME CRANIEN CHEZ L’ENFANT HEAD TRA UMA IN CHILDREN Mod6rateurs : J. BERMAN (Winston...Salem, Etats-Unis), Ph. MEYER (Paris, France) 08h30 Epid6miologie et physio-pathologie des traumatismes craniens chez 1’enfant Epidemiology and...pathophysiology of head injuries in children P. OAKLEY (Staffordshire, Royaume-Uni) 09h00 R6animation pr6-hospitali~re du traumatisme cranien grave

  13. Acquiring Procedural Skills from Lesson Sequences.

    Science.gov (United States)

    1985-08-13

    Teachers of Mathematics . Washington, D)C: NCTM . Brueckner, I..J. (1930) Diagnostic aund remedial teaching in arithmetic. Philadelphia. PA: Winston. Burton...arithmetic and algebra, fr-m multi-lesson curricula. The central hypothesis is that students and teachers obey cc: :-.entions that cause the goal hierarchy...students and • . teachers obey conventions that cause the goal hierarchy of the acquired procedure to be a particular structural function of the sequential

  14. Learning New Principles from Precedents and Exercises.

    Science.gov (United States)

    1981-05-01

    number of corresponding things, for some Shakespeare comparisons are as follows: Patrick H. Winston - 34- Notes HA HA JU OT TA MAcbeth 199 HAmlet 110...rules to end up in the middle level of the class hierarchy. On working with Shakespeare , a system would learn some things about nobles, less about people...Matcher Performance on Shakespeare Precis One curious sort of robust behavior was observed in the matcher: it gives the same relative results even as

  15. On-the-Job Training and Social Learning Theory. A Literature Review

    Science.gov (United States)

    1980-05-01

    and discussed by Albert Bandura (47). The principles of social learning theory and learning from models are first described. Then a series of rules...developed by Bandura and his students (47, 48, 49) to be the most useful theory to account for observational learning and to provide a basis for...Learning Theory and Its Application 47. Bandura , A. Principles of Behavior Modification, New York: Holt, Rinehart & Winston, 1969. 48. Bandura , A

  16. Tribute to Emil Wolf: Science and Engineering Legacy of Physical Optics

    Science.gov (United States)

    2004-09-23

    1983; his Ph.D. research examined a novel nonimag - ing solar thermal collector with Prof. Roland Winston. While at NRL, Dr. Snail has published more...advanced illumination systems, sensors, and nonimaging optical devices. This SPIE Press book pays tribute to Emil Wolf (see Fig. 1) for his pio- neering...who described the effect of nonimage forming optical systems and scattering media in terms of the Mueller formalism; Edwin H. Land,† who invented the

  17. U.S. Declining Global Rankings in Math and Science and the Impact on Our National Security: Policy Options to Elicit Another Sputnik Moment

    Science.gov (United States)

    2014-03-01

    regulation activity, such as coming to school prepared and with the necessary books is an indicator of student engagement and is necessary for the...policy or program.  Analysis on level of policy/program focused on developing student engagement , both on the individual and group level. This...University, Winston-Salem, NC. 88 Rhodes, H. J. (2007). Confronting the challenges of student engagement : A case study of a school-based

  18. Lyderio minties veiklos įtaka organizacijos vystymuisi

    OpenAIRE

    Kvedaravičius, Jonas Edmundas; Jesevičiūtė-Ufartienė, Laima

    2007-01-01

    People are the only objects in the Earth that are able to use their mind and intellective activity. Intellection difference people from animals: people difference their ability to think about intellection (Winston, 2005). Manager is the person using his / her intellective activity in organization. Manager in this article is considered as a top manager in organization. In the authors' opinion, manager is considered as leader if he / she has various abilities. The leader is creator of value in ...

  19. On Resisting Social Influence

    Science.gov (United States)

    1979-09-01

    Eds.), Law , Justice and the individual in society: Psychological and legal issues. New York: Holt, Rinehart and Winston, 1977, 198-223. Hartman, J. J...Kadish, M. R., & Kadish, S. H. Discretion to disobey: A study of lawful departures from legal rules. Stanford, Calif.: Stanford University Press, Lifton, R...30 Stoner, C., & Parke, J. All God’s children. New York: Penguin, 1979. Szasz , T. Patty Hearst’s conversion: Some call it brainwashing. The New

  20. Why can't China clean up its act?

    OpenAIRE

    Heugens, Pursey

    2017-01-01

    textabstractWinston Churchill once described the Soviet Union as 'a riddle wrapped in a mystery inside an enigma.’ Modern China is a very different story. By definition, the workings of the world’s largest economy (by purchasing power parity) can’t really be hidden from view nearly as easily. However, the sheer scale means that certain aspects of that vast market’s workings are still not all that easy to understand.

  1. Optimal Design of a Hexakis Icosahedron Vacuum Based Lighter than Air Vehicle

    Science.gov (United States)

    2017-03-23

    tionary, such as using a genetic algorithm [27] [28]. Other researchers have solved these design problems by employing simulated annealing [29]. Derivative...injection array [40] and structure determi- 19 nation of nanomaterials [41]. The applications of the algorithm are varied due to its generality. Unlike a...1994. 15. W. L. Winston, Operations Research: Applications and Algorithms . Duxbury Press, fourth ed., Jul 2003. 16. F. S. Hillier and G. J. Lieberman

  2. BOLD magnetic resonance imaging in nephrology

    OpenAIRE

    Hall ME; Jordan JH; Juncos LA; Hundley WG; Hall JE

    2018-01-01

    Michael E Hall,1,2 Jennifer H Jordan,3 Luis A Juncos,1,2 W Gregory Hundley,3 John E Hall2 1Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA; 2Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA; 3Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Magnetic resonance (MR) imaging, a non-invasive modality that provides ana...

  3. Enduring Strategic Rivalries

    Science.gov (United States)

    2014-08-01

    Humanist slogan that first became popular in the fifteenth century, Bella gerant alii; tu, felix Austria, nube—Others make war; you, happy Habsburgs, marry...and perceptions of Winston Churchill for the British to hang on in the face of the existential threat that the Third Reich represented. This essay...to Western actions instead of the existential problem caused by a wave of internal rebellions, whose causes were internal, overlaid by Chinese

  4. Analysis of the Salvation Army World Service Offices Disaster Relief Capabilities

    Science.gov (United States)

    2017-03-01

    information in an operational context for military and civilian leaders . This figure was adapted by Apte and Yoho from Joint Publication 4-0, Joint...envelopes called “firing cartridges” (Gariepy, 2009, p. 15). Militaristic tendencies also influenced the autocratic leadership embraced and promoted by...which oversaw all Army activity from London (Winston, 1999). An autocratic ruler, Booth would not tolerate threats to his centralized power and

  5. Critical appraisal of the Spanner™ prostatic stent in the treatment of prostatic obstruction

    OpenAIRE

    McKenzie, Patrick; Badlani, Gopal

    2011-01-01

    Patrick McKenzie1, Gopal Badlani11Department of Urology, Wake Forest University School of Medicine, Winston-Salem NC, USAAbstract: The Spanner™ stent was first used in patients to relieve bladder outlet obstruction (BOO), and has recently been used in patients following transurethral microwave thermotherapy and men unfit for surgical intervention. We review the current literature on the role of the Spanner stent in treating prostatic obstruction compared to previously reported cases...

  6. Numerical Optimization Using Desktop Computers

    Science.gov (United States)

    1980-09-11

    geophysical, optical and economic analysis to compute a life-cycle cost for a design with a stated energy capacity. NISCO stands for NonImaging ...more efficiently by nonimaging optical systems than by conventional image forming systems. The methodology of designing optimized ronimaging systems...compound parabolic concentrating iWelford, W. T. and Winston, R., The Optics of Nonimaging Concentrators, Light and Solar Energy, p. ix, Academic

  7. Super-Radiant Free Electron Laser Measurement and Detection

    Science.gov (United States)

    2013-09-01

    Optical Society of America, vol. 48, no. 8, pp. 531–533, Aug. 1958. [17] W. T. Welford and R. Winston, The Optics of Nonimaging Concentrators: Light...they can operate at the high average power with excellent optical beam quality that is needed in many military applications. A current project between...still maintaining reasonable size cavities, which may reduce power requirements for the cryoplant. This thesis will discuss variety of optical

  8. A Full-Color, High-Resolution Laser Projector for a Flight Simulator Visual Display

    Science.gov (United States)

    1993-08-01

    Optical Engineering, 31 (11), 2300-2311. Welford, W.T., & Winston , R. (1989). High collection nonimaging optics . San Diego, CA: Academic Press. 17 ... optically combines the output from red, green, and blue LCD panels to produce color. A light valve extracts the three primaries from a single xenon... concentrated than the noncoherent light sources used in light valve, CRT, LCD, and other displays. An obvious benefit of this is the ability to

  9. Solid State Research

    Science.gov (United States)

    1991-08-15

    G. E. Betts Analog Optical Links for High Dynamic L. M. Johnson Range C. H. Cox III Nonimaging Concentrators for Diode- P. Lacovara Pumped Slab Lasers...P. Gleckman* SPIEs 1991 International R. Holman* Symposium on Optical Science R. Winston * and Engineering, San Diego, California, Free-Space Board-to...xxv 1. ELECTROOPTICAL DEVICES 1 1.1 Optical Phase Difference Measurement and Correction Using AIGaAs Integrated Guided-Wave Components 1 1.2 Two

  10. Aircraft Position Measurement Using Laser Beacon Optics.

    Science.gov (United States)

    1981-01-01

    8217Comparison of Solar Concentrators .’ Solar Energy, Vol. 10, p. 93, 1976. 7. Winston , R., ’Light Collection Within the Framework of Goemetrical Optics ...8217 J. Optical Society of Am., Vol. 60, p. 245, 1970. 8. Welford, W. T., tics of Nonimaging Concentrators . New York, Academic Press, T978. 9. Bracewell...helicopter pilot and the flight engineer on board the YO-3A. This thesis will concentrate on the development of the laser beacon, the detector optics

  11. Laser Diode Pumped Solid State Lasers

    Science.gov (United States)

    1987-01-01

    Report N66001-83-C-0071, 17 April 1986, prepared for NOSC. 4.6 W.T. Welford, R. Winston , "The Option of Nonimaging Concentrators ," Academic Press, 1978...by non-imac optics such as reflective or refractive flux concentrators . Simple considerations regarding the optimum pumping configuration, high marks...reduced if the arrays can stand-off from the Nd:YAG laser. As mentioned before, compound parabolic concentrators or refractive optics cat employed to

  12. Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema

    Directory of Open Access Journals (Sweden)

    Kaur R

    2014-12-01

    Full Text Available Ravdeep Kaur, Aerik Anthony Williams, Catherine Baker Swift, Jason W Caldwell Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NC, USA Abstract: Acquired angioedema is often associated with significant morbidity. An underlying lymphatic malignancy, autoimmune disorder, adenocarcinoma, or other malignancy may be present. Screening for these disorders should occur in all patients with acquired angioedema as treatment may result in resolution of angioedema. Keywords: complement, C1-INH deficiency, ecallantide, hemopathy

  13. SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

    International Nuclear Information System (INIS)

    Kerns, J; Yaldo, D

    2016-01-01

    Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the time of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.

  14. Lei nº 2.880, de 4 de abril de 1963 | Decreto 4.846, de 25 de setembro de 1967

    Directory of Open Access Journals (Sweden)

    Marta Maria Araujo

    2018-04-01

    Full Text Available Nos governos de Aluizio Alves (1961-1966 e de Monsenhor Walfredo Gurgel (1966-1971, respectivamente, no Estado do Rio Grande do Norte, foram criados o Instituto “Padre Miguelinho” (1963 e o Colégio Estadual “Winston Churchill” (1967 na capital Natal. O Instituto “Padre Miguelinho abrangia quatro unidades educacionais: Jardim de Infância “Professor Anfilóquio Câmara”; Grupo Escolar “Professor Luís Soares”; Colégio Estadual do Alecrim e o Ginásio Industrial. O Colégio Estadual “Winston Churchill” compreendia o Ensino Médio com o 1° e 2° ciclos (ginasial e colegial. Nesta Seção de Documento da Revista Educação em Questão, o Conselho Editorial publica a Lei n° 2.880, de 4 de abril de 1963, que criou o Instituto “Padre Miguelinho e o Decreto n° 4.846, de 25 de setembro de 1967, que criou o Colégio Estadual “Winston Churchill”, para fins de estudo e pesquisa de Historiadores da Educação.

  15. SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Kerns, J [UT MD Anderson Cancer Center, Houston, TX (United States); Yaldo, D [Advocate Health Care, Park Ridge, IL (United States)

    2016-06-15

    Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the time of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.

  16. Orbital-Optimized MP3 and MP2.5 with Density-Fitting and Cholesky Decomposition Approximations.

    Science.gov (United States)

    Bozkaya, Uğur

    2016-03-08

    Efficient implementations of the orbital-optimized MP3 and MP2.5 methods with the density-fitting (DF-OMP3 and DF-OMP2.5) and Cholesky decomposition (CD-OMP3 and CD-OMP2.5) approaches are presented. The DF/CD-OMP3 and DF/CD-OMP2.5 methods are applied to a set of alkanes to compare the computational cost with the conventional orbital-optimized MP3 (OMP3) [Bozkaya J. Chem. Phys. 2011, 135, 224103] and the orbital-optimized MP2.5 (OMP2.5) [Bozkaya and Sherrill J. Chem. Phys. 2014, 141, 204105]. Our results demonstrate that the DF-OMP3 and DF-OMP2.5 methods provide considerably lower computational costs than OMP3 and OMP2.5. Further application results show that the orbital-optimized methods are very helpful for the study of open-shell noncovalent interactions, aromatic bond dissociation energies, and hydrogen transfer reactions. We conclude that the DF-OMP3 and DF-OMP2.5 methods are very promising for molecular systems with challenging electronic structures.

  17. Accountability: a missing construct in models of adherence behavior and in clinical practice

    Directory of Open Access Journals (Sweden)

    Oussedik E

    2017-07-01

    Full Text Available Elias Oussedik,1 Capri G Foy,2 E J Masicampo,3 Lara K Kammrath,3 Robert E Anderson,1 Steven R Feldman1,4,5 1Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 4Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Piano lessons, weekly laboratory meetings, and visits to health care providers have in common an accountability that encourages people to follow a specified course of action. The accountability inherent in the social interaction between a patient and a health care provider affects patients’ motivation to adhere to treatment. Nevertheless, accountability is a concept not found in adherence models, and is rarely employed in typical medical practice, where patients may be prescribed a treatment and not seen again until a return appointment 8–12 weeks later. The purpose of this paper is to describe the concept of accountability and to incorporate accountability into an existing adherence model framework. Based on the Self-Determination Theory, accountability can be considered in a spectrum from a paternalistic use of duress to comply with instructions (controlled accountability to patients’ autonomous internal desire to please a respected health care provider (autonomous accountability, the latter expected to best enhance long-term adherence behavior. Existing adherence models were reviewed with a panel of experts, and an accountability construct was incorporated into a modified version of Bandura’s Social Cognitive Theory. Defining accountability and incorporating it into an adherence model will facilitate the development of measures of accountability as well

  18. Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol

    Directory of Open Access Journals (Sweden)

    Vitolins MZ

    2018-04-01

    Full Text Available Mara Z Vitolins,1 L Douglas Case,1 Stephen R Rapp,2 Mark O Lively,3 Edward G Shaw,4 Michelle J Naughton,5 Jeffrey Giguere,6 Glenn J Lesser7 1Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; 6Greenville Community Oncology Research Program of the Carolinas, Greenville, SC, USA; 7Department of Internal Medicine-Hematology and Oncology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10 plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels.Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers. Participants were categorized by self-reported adherence; Kruskal–Wallis tests compared changes in alpha-tocopherol and CoQ10 levels between self-reported adherence groups.Results: Women (N=155 provided baseline and post-treatment biomarkers; 147 completed at least one diary. While changes in alpha-tocopherol and CoQ10 levels were moderately correlated, correlations ranged from 0.40 to 0.48, association between self-reported adherence and plasma alpha-tocopherol or CoQ10 levels was weak; correlations ranged from 0.10 to 0.29 at weeks 8, 16, and 24. Some participants with high self-reported adherence actually

  19. SU-E-T-48: Automated Quality Assurance for XML Controlled Linacs

    International Nuclear Information System (INIS)

    Valdes, G; Morin, O; Pouliot, J; Chuang, C

    2014-01-01

    Purpose: To automate routine imaging QA procedures so that complying with TG 142 and TG 179 can be efficient and reliable. Methods: Two QA tests for a True Beam Linac were automatized. A Winston Lutz test as described by Lutz et al 1 using the Winston Lutz test kit from BrainLab, Germany and a CBCT Image Quality test as described in TG 179 using the EMMA phantom, Siemens Medical Physics, Germany were performed in our True Beam. For each QA procedure tested, a 3 step paradigm was used. First, the data was automatically acquired using True Beam Developer Mode and XML scripting. Second, the data acquired in the first step was automatically processed using in-home grown Matlab GUIs. Third, Machine Learning algorithms were used to automatically classify the processed data and reports generated. Results: The Winston Luzt test could be performed by an experienced medical physicist in 29.0 ± 8.0 min. The same test, if automated using our paradigm, could be performed in 3.0 ± 0.1 min. In the same lieu, time could be substantially saved for image quality tests. In this case, the amount of time saved will depend on the phantoms used and the initial localization method. Additionally, machine learning algorithms could automatically identify the roots of the problems if any and possibly help reduce machine down time. Conclusion: Modern linear accelerators are equipped with advanced 2D and 3D imaging that are used for patient alignment substantially improving IGRT protocols. However, this extra complexity exponentially increases the number of QA tests needed. Using the new paradigm described above, not only bare minimum but best practice QA programs could be implemented with the same manpower. This work is supported by Varian, Palo Alto, CA

  20. Making IT Work

    Science.gov (United States)

    2015-10-01

    Development Life Cycle (SDLC)……………………… 6 Figure 2. The Waterfall Model …………………………………………………… 7 Figure 3. Scrum Development Lifecycle………………………………………… 14...invites failure.”27 Figure 2. The Waterfall Model . (Adapted from Royce, Dr. Winston W., “Managing The Development of Large Software...5 Waterfall

  1. Future Naval Use of COTS Networking Infrastructure

    Science.gov (United States)

    2009-07-01

    G . Mykityshyn White Oak Group Dr. John C. Sommerer Johns Hopkins Applied  Physics  Laboratory Professor Patrick H. Winston Massachusetts Institute of...Alliance Manager, Amazon Mr. Mike Culver Web Services Evangelist, Amazon Mr. Paul Horvath Solutions Architect, Amazon Mr. Stephen Schmidt General...Gartner Mr. Robert Mason Gartner Mr. Jason Cain Google Earth Enterprise Sales Engineer Mr. Dylan Lorimer Strategic Partner Manager, Geo Content

  2. Disaster risk reduction and sustainable development for small island developing states.

    Science.gov (United States)

    Shultz, James M; Cohen, Madeline A; Hermosilla, Sabrina; Espinel, Zelde; McLean, Andrew

    2016-01-01

    In contrast to continental nations, the world's 52 small island developing states (SIDS) are recognized as a collective of countries that experience disproportionate challenges for sustainable development related to their geography, small size, and physical isolation. These same states also face elevated risks for disaster incidence and consequences particularly in the realms of climate change, sea level rise, natural disasters (tropical cyclones, earthquakes, tsunamis, volcanoes), and marine hazardous materials spills. Cyclone Winston's direct impact on Fiji in 2016 and Cyclone Pam's landfall over Vanuatu in 2015 provide case examples illustrating the special vulnerabilities of the SIDS.

  3. Europe from challenges of war towards challenges of peace

    OpenAIRE

    Fahredin Shabani; Ibrahim Gashi

    2017-01-01

    The end of the WWII, did not bring peace and harmony among the peoples of Europe and World as expected. Enmity of the war time created such a deep ditch, which could not be overcome for a short time. What’s more, even among the allies-winners of the war, friendship and cooperation did not last too long. Very soon, two-three years after the end of the war, Europe was separated by an iron curtain, as Winston Churchill, the British prime minister would call it. The shadow of this division, first...

  4. The Role of Siah1-Induced Degradation of beta-Catenin in Androgen Receptor Signaling

    Science.gov (United States)

    2007-11-01

    biological responses to DNA damage: Insights from yeast and p53. Nat. Cell Biol. 3, E277–E286. Winston, J.T., Strack, P., Beer -Romero, P., Chu, C.Y...apoptosis, depending on the cell line tested [3]. The findings suggest that p53-mediated induction of Siah1 expression could play an important role in the...hypothesis that Siah1 is an important mediator of p53’s effects in prostate cancers. If the hypothesis proves to be correct, then the results derived

  5. The enhanced running performance-GRAAL2001 project

    Energy Technology Data Exchange (ETDEWEB)

    Jarnot, M.; Binzen, O.; Gebauer, J.; Jarnot, E.; Plaga, R.

    2002-07-01

    In order find a method to test each of the Graals Experiment 63 heliostats for it's correct aiming position we sent a laser pulse (532 nm, 2.5 mj, 10 ns) from the central tower to the heliostats under observation. The atmospheric back reflection were captured by a group of heliostats and received by a photomultiplier equipped with a Winston cone. Reflected light from up to 17 km distance has been analysed. The sensitivity of this method for the angular accuracy was better than 10 mrad. (Author) 2 refs.

  6. STS-87 Mission Specialists Scott and Doi with EVA coordinator Laws participate in the CEIT for their

    Science.gov (United States)

    1997-01-01

    Participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center are STS-87 crew members, assisted by Glenda Laws, extravehicular activity (EVA) coordinator, Johnson Space Center, at left. Next to Laws is Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, who is looking on as Mission Specialist Winston Scott gets a hands-on look at some of the equipment. The STS-87 mission will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks.

  7. STS-72 Flight Day 7

    Science.gov (United States)

    1996-01-01

    On this seventh day of the STS-72 mission, the flight crew, Cmdr. Brian Duffy, Pilot Brent W. Jett, and Mission Specialists Leroy Chiao, Daniel T. Barry, Winston E. Scott, and Koichi Wakata (NASDA), awakened to music from the Walt Disney movie, 'Snow White and the Seven Dwarfs.' Chiao and Scott performed the second spacewalk of the mission where they tested equipment and work platforms that will be used in building the planned International Space Station. This spacewalk was almost seven hours long. Wakata conducted an interview with and answered questions from six graders from a Japanese school in Houston, Texas.

  8. Negative muon spin precession measurement of the hyperfine states of muonic sodium

    International Nuclear Information System (INIS)

    Brewer, J.H.; Ghandi, K.; Froese, A.M.; Fryer, B.A.

    2005-01-01

    Both hyperfine states of muonic 23 Na and the rate R of conversion between them have been observed directly in a high field negative muon spin precession experiment using a backward muon beam with transverse spin polarization. The result in metallic sodium, R=13.7±2.2 μs -1 , is consistent with Winston's prediction in 1963 based on Auger emission of core electrons, and with the measurements of Gorringe et al. in Na metal, but not with their smaller result in NaF. In NaOH we find R=23.5±8 μs -1 , leaving medium-dependent effects ambiguous

  9. Microsoft Office Excel 2007 data analysis and business modeling

    CERN Document Server

    Winston, Wayne L

    2007-01-01

    Master the analysis and business modeling techniques that help you transform your data into bottom-line results. Award-winning business professor and corporate consultant Wayne Winston shares the best of his real-world experience in this practical guide-now updated for Excel 2007. Use Wayne's proven practices and hands-on exercises to help you work smarter, make better decisions, and gain the competitive edge. Solve real-world business problems with Excel 2007! Maximize profits-determine NPV, optimize your product mix, calculate ROICreate best, worst, and most-likely case scenarios for sal

  10. Immersive Televisual Environments: Spectatorship, Stereoscopic Vision and the Failure of 3DTV

    Directory of Open Access Journals (Sweden)

    Ilkin Mehrabov

    2015-09-01

    Full Text Available This article focuses on one of the most ground-breaking technological attempts in creating novel immersive media environments for heightened televisual user experiences: 3DTV, a Network of Excellence funded by the European Commission 6th Framework Information Society Technologies Programme. Based on the theoretical framework outlined by the works of Jonathan Crary and Brian Winston, and on empirical data obtained from author’s fieldwork and laboratory visit notes, as well as discussions with practitioners, the article explores the history of stereoscopic vision and technological progress related with it, and looks for possible reasons of 3DTV’s dramatic commercial failure.

  11. Venezuelan oil - the unfulfilled promise

    OpenAIRE

    2007-01-01

    Winston Churchill once said that ‘Russia was a riddle wrapped in a mystery inside an enigma.’ One is reminded of these words when approaching the subject of Venezuela’s oil strategy in the last few years. Venezuelan politics, and by implication its economy, have always been product and hostage to oil and the capriciousness of the oil price. A founder member of OPEC, and throughout history a very vocal, and at times vociferous advocate for the rights of the sovereign state against the inte...

  12. Joint Force Quarterly. Number 3, Winter 1993-94

    Science.gov (United States)

    1994-01-01

    Winter 1993–94 This article is based on the winning entry in the 1992 LtCol Richard Higgins, USMC, memorial essay contest sponsored by the National War...TRANSCOM pledges to develop a new system that lives up to Winston Churchill’s dictum: “Victory is the beautiful bright coloured flower. Transport is...fighter wings 7 Reserve fighter wings 7 Reserve fighter wings 10 Reserve fighter wings Force Enchancements 1803 Ltrs & JW Rev 3/27/04 7:31 AM Page 107

  13. Anatomic and physiopathologic changes affecting the airway of the elderly patient: implications for geriatric-focused airway management

    Directory of Open Access Journals (Sweden)

    Johnson KN

    2015-12-01

    Full Text Available Kathleen N Johnson,1 Daniel B Botros,1 Leanne Groban,1–4 Yvon F Bryan11Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Section on Molecular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USAAbstract: There are many anatomical, physiopathological, and cognitive changes that occur in the elderly that affect different components of airway management: intubation, ventilation, oxygenation, and risk of aspiration. Anatomical changes occur in different areas of the airway from the oral cavity to the larynx. Common changes to the airway include tooth decay, oropharyngeal tumors, and significant decreases in neck range of motion. These changes may make intubation challenging by making it difficult to visualize the vocal cords and/or place the endotracheal tube. Also, some of these changes, including but not limited to, atrophy of the muscles around the lips and an edentulous mouth, affect bag mask ventilation due to a difficult face-mask seal. Physiopathologic changes may impact airway management as well. Common pulmonary issues in the elderly (eg, obstructive sleep apnea and COPD increase the risk of an oxygen desaturation event, while gastrointestinal issues (eg, achalasia and gastroesophageal reflux disease increase the risk of aspiration. Finally, cognitive changes (eg, dementia not often seen as related to airway management may affect patient cooperation, especially if an awake intubation is required. Overall, degradation of the airway along with other physiopathologic and cognitive changes makes the elderly population more prone to complications related to airway management. When deciding which airway devices and techniques to use for intubation, the clinician should also consider the

  14. QALMA: A computational toolkit for the analysis of quality protocols for medical linear accelerators in radiation therapy

    Science.gov (United States)

    Rahman, Md Mushfiqur; Lei, Yu; Kalantzis, Georgios

    2018-01-01

    Quality Assurance (QA) for medical linear accelerator (linac) is one of the primary concerns in external beam radiation Therapy. Continued advancements in clinical accelerators and computer control technology make the QA procedures more complex and time consuming which often, adequate software accompanied with specific phantoms is required. To ameliorate that matter, we introduce QALMA (Quality Assurance for Linac with MATLAB), a MALAB toolkit which aims to simplify the quantitative analysis of QA for linac which includes Star-Shot analysis, Picket Fence test, Winston-Lutz test, Multileaf Collimator (MLC) log file analysis and verification of light & radiation field coincidence test.

  15. Infrared Applications of Semiconductors II: Symposium Held in Boston, Massachusetts on December 1-4, 1997

    Science.gov (United States)

    1997-12-01

    Winston, ’The Optics of Nonimaging Concentrators’, Academic Press, 1978 15. C.T. Elliott, N.T. Gordon et. al., J. Elect. Mater., 25,1139 (1996) 16...Moiseev, A.n. Imenkov, O.G. Ershov, and Yu.F. Yakovlev *High-Power, Low-Threshold, Optically Pumped Type-ll Quantum-Well Lasers 107 Chih-Hsiang...H. Bichl, K. Unterrainer, E. Qornik, P. Kruck, M. Helm, and J.n. tieyman Novel Piezoelectric Heterostructure for All- Optical IR Light Modulation

  16. Optical Computing Research.

    Science.gov (United States)

    1987-10-30

    1489-1496, 1985. 13. W.T. Welford and R. Winston, The Optics of Nonimaging Concentrators, Academic Press, New York, N.Y., 1978 (see Appendix A). 14. R.H...AD-fIB? Ŗ OPTICAL CONPIITINO RESEAIRCII(U STANFORD UlNIV CA STINFORD / ELECTRONICS LASS J N 0000W4 30 OCT 97 SMAFOSR-TR-S?-1635 RFOSR-96...Force Base ELEMENT NO. NO. NO. NO. Washington, DC 20332-6448 11. TITLE ,Include Security ClaaticaonUNCLASSIFIED 61102F 2305 B4 OPTICAL COMPUTING RESEARCH

  17. Second-Generation System for Three-Dimensional Imaging Using a Single Laser Pulse

    Science.gov (United States)

    1990-01-23

    Welford and t. Winston , The Optics of Nonimaging Concentrators , Academic Press, New York, 1978. 14. N. F. Borelli, D. L. Morse, R. H. Bellman, and W. L...inserting such an optical concentrator , we can use a practical- 9ber layout for the converter with moderate ratio of fiber core to unit cell area and...ABSTRACT (Maximum 200 words)15 199t This paper describes the design of a second-generation version of an optical detector capable of producing a 3-D

  18. Laser Induced Optical Damage in Solids

    Science.gov (United States)

    1991-07-01

    the full angle subtended by the object. 1 The sun, which subtends 20 = 0.54’, can be concentrated about 46,000 times. Using nonimaging techniques...cone, these nonimaging techniques can concentrate sunlight to intensities as high as -108 W/m 2, (or 104 W/cm 2 as is more often reported when dealing...REFERENCES 1. P. Gleckman. J. O’Gallagher, and R. Winston , "Approaching the Irradiance of the Sun Through Norimaging Optics ," Optics News 15:33, May 1989

  19. The LIFE Cognition Study: design and baseline characteristics

    OpenAIRE

    Sink, Kaycee M; Espeland, Mark A; Rushing, Julia; Castro, Cynthia M; Church, Timothy S; Cohen, Ronald; Gill, Thomas M; Henkin, Leora; Jennings, Janine M; Kerwin, Diana R; Manini, Todd M; Myers, Valerie; Pahor, Marco; Reid, Kieran F; Woolard, Nancy

    2014-01-01

    Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of ...

  20. Evolução clínica e capacidade funcional de pacientes com cardiomiopatia dilatada após quatro anos do transplante Clinical and functional capacity of patients with dilated cardiomyopathy after four years of transplantation

    Directory of Open Access Journals (Sweden)

    Daniela Gardano Bucharles Mont'Alverne

    2012-12-01

    Full Text Available OBJETIVO: Avaliar a evolução do paciente miocardiopata após transplante (Tx cardíaco, analisando sua sobrevida, complicações trans e pós-operatórias e respostas cardiovasculares após cerca de quatro anos do procedimento cirúrgico. MÉTODOS: A pesquisa foi realizada no período de fevereiro a maio de 2011, com pacientes submetidos a Tx cardíaco no Hospital Dr. Carlos Alberto Studart Gomes - Hospital de Messejana (HDM. A amostra foi composta de todos os pacientes transplantados no ano de 2007 no referido hospital. Inicialmente, foi aplicada uma ficha de avaliação, coletando dados dos prontuários, sobre a evolução do paciente no período trans e pós-operatório até a alta hospitalar. Após a coleta dessas informações, os pacientes foram submetidos ao teste da caminhada dos seis minutos (TC6. Os valores encontrados na distância percorrida foram comparados aos valores de referência esperados para a população utilizando a equação de Enright e Sherrill. RESULTADOS: Do total de 24 pacientes que realizaram Tx cardíaco no HDM no ano de 2007, 14 foram avaliados e 10 excluídos do estudo. Com relação às complicações, no período transoperatório, a mais evidenciada foi a disfunção do ventrículo direito (64,3% e, no pós-operatório, quadro de taquicardia (64,3%. Analisando o TC6 observou-se diminuição de 11,6% na distância percorrida quando comparada à distância estimada (486 ± 55 m, 550 ± 59 m, respectivamente. CONCLUSÃO: Os resultados obtidos neste estudo perante o TC6 evidenciam que as respostas cardiovasculares dos pacientes avaliados estão abaixo do estimado, contudo dentro da faixa de normalidade estabelecida.OBJECTIVE: To evaluate patient with cardiomyopathy's progress after cardiac transplant, by analyzing his survival, complications and cardiovascular responses after nearly four years of surgery. METHODS: The survey was conducted from February to May 2011, with patients undergoing cardiac transplantation

  1. Validação da bateria "Beck" de testes de habilidades para atletas brasileiros de "rugby" em cadeira de rodas Validation of beck battery of skills tests to Brazilian players of wheelchair rugby

    Directory of Open Access Journals (Sweden)

    José Irineu Gorla

    2011-09-01

    Full Text Available O "Rugby" em Cadeira de Rodas é uma modalidade praticada por sujeitos com tetraplegia ou tetra-equivalência, desde 2005 no Brasil, onde existem aproximadamente 10 equipes em atividade. A avaliação motora é um dos meios de controle do treinamento que possibilita conquistar avanços no planejamento. A bateria "Beck" de testes de habilidades (manejo de bola, precisão de passes, bloqueio, velocidade e passes de longa distância para atletas da modalidade foi desenvolvida nos EUA por Yilla e Sherrill (1998. O objetivo deste estudo foi analisar os critérios de autenticidade científica da bateria para a população de atletas brasileiros. Os resultados de duas avaliações com a bateria (teste e re-teste realizadas com 11 atletas (média de idade 27,59 ± 5,37 anos, tempo de lesão 8,19 ± 3,83 anos, foram registrados por três avaliadores, o que possibilitou a análise de objetividade, fidedignidade e consistência interna. Foram utilizadas as ferramentas ANOVA para análise de objetividade e, coeficiente de correlação intraclasse e teste t para análise de fidedignidade e consistência. Não foram encontradas diferenças entre os resultados dos diferentes avaliadores (valores de p variando de 0,45 a 1,00 e os valores de correlação intraclasse encontrados (variação de r de 0,78 a 0,99 permitem concluir que a bateria é consistente e fidedigna. Os resultados encontrados neste estudo são evidências de que os critérios de autenticidade científica para a bateria são satisfeitos e a bateria pode ser considerada um instrumento válido para avaliação motora de atletas brasileiros de "rugby" em cadeira de rodas.The Wheelchair Rugby is a sport practiced by subjects with tetraplegia or tetra-equivalence, since 2005 in Brazil, where there are approximately 10 teams in business. The motricity evaluation is a means of training control that allows achieve real progress in planning. The BECK battery of skills tests (ball handling, precision

  2. Acquired resistance of malarial parasites against artemisinin-based drugs: social and economic impacts

    Directory of Open Access Journals (Sweden)

    Johanna M Porter-Kelley

    2010-08-01

    Full Text Available Johanna M Porter-Kelley1, Joann Cofie2, Sophonie Jean2, Mark E Brooks1, Mia Lassiter1, DC Ghislaine Mayer21Life Sciences Department, ­Winston-Salem State University, Winston Salem, NC, USA; 2Department of Biology, Virginia Commonwealth University, Richmond, VA, USAAbstract: Malaria, a disease of poverty and high morbidity and mortality in the tropical world, has led to a worldwide search for control measures. To that end, good antimalarial chemotherapies have been difficult to find in the global market and those that seem to be most effective are rapidly becoming ineffective due to the emergence and spread of drug resistance. Artemisinin, a very effective yet expensive antimalarial, has quickly become the recommended drug of choice when all other possibilities fail. However, for all its promise as the next great antimalarial, the outlook is bleak. Resistance is developing to artemisinin while another effective antimalarial is not in sight. Malaria endemic areas which are mostly in developing countries must deal with the multifaceted process of changing and implementing new national malaria treatment guidelines. This requires complex interactions between several sectors of the affected society which in some cases take place within the context of political instability. Moreover, the cost associated with preventing and containing the spread of antimalarial resistance is detrimental to economic progress. This review addresses the impact of artemisinin resistance on the socioeconomic structure of malaria endemic countries.Keywords: artemisinin-based drugs, social, economic, malarial parasite resistance

  3. SU-E-T-234: Daily Quality Assurance for a Six Degrees of Freedom Couch Using a Novel Phantom

    International Nuclear Information System (INIS)

    Woods, K; Woollard, J; Ayan, A; Sandu, A; Sommerfeld, J; Gupta, N; Laurel, A

    2015-01-01

    Purpose: To test the accuracy and reproducibility of both translational and rotational movements for a couch with six degrees of freedom (6DoF) using a novel phantom design Methods: An end-to-end test was carried out using two different phantoms. A 6 cm3 cube with a central fiducial BB (WL-QA Sun Nuclear) and a custom fabricated rectangular prism (31 cm x 8 cm x 8 cm), placed on a baseplate with known angular offsets for pitch, roll and yaw with a central fiducial BB and unique surface structures for registration purposes, were used. The end-to-end test included an initial CT simulation for a reference study, setup to an offset mark on each phantom, registration of the reference CT to the acquired cone-beam CT, and final Winston-Lutz delivery at four cardinal gantry angles. Results for both translational and rotational movements were recorded and compared for both phantoms. Results: Translational and rotational measurements were performed with a PerfectPitch (Varian) couch for 10 trials for both phantoms. Distinct translational shifts were [−5.372±0.384mm, −10.183±0.137mm, 14.028±0.155mm] for the cube and [7.520±0.159mm, −9.117±0.101mm, 16.273±0.115mm] for the prototype phantom for lateral, longitudinal, and vertical shifts, respectively. Distinct rotational adjustments were [1.121±0.102o, −1.067±0.235o, −2.662±0.380o] for the cube and [2.534±0.059o, 1.994±0.025o, 2.094±0.076o] for the prototype for pitch, roll, and yaw, respectively. Winston-Lutz test results performed after 6DoF couch correction from each cardinal gantry angle ranged from 0.26–0.72mm for the cube and 0.55–0.86mm for the prototype. Conclusion: The prototype phantom is more precise for both translational and rotational adjustments compared to a commercial phantom. The design of the prototype phantom allows for a more discernible visual confirmation of correct translational and rotational adjustments with the prototype phantom. Winston-Lutz results are more accurate for the

  4. Quality assurance for a six degrees-of-freedom table using a 3D printed phantom.

    Science.gov (United States)

    Woods, Kyle; Ayan, Ahmet S; Woollard, Jeffrey; Gupta, Nilendu

    2018-01-01

    To establish a streamlined end-to-end test of a 6 degrees-of-freedom (6DoF) robotic table using a 3D printed phantom for periodic quality assurance. A 3D printed phantom was fabricated with translational and rotational offsets and an imbedded central ball-bearing (BB). The phantom underwent each step of the radiation therapy process: CT simulation in a straight orientation, plan generation using the treatment planning software, setup to offset marks at the linac, registration and corrected 6DoF table adjustments via hidden target test, delivery of a Winston-Lutz test to the BB, and verification of table positioning via field and laser lights. The registration values, maximum total displacement of the combined Winston-Lutz fields, and a pass or fail criterion of the laser and field lights were recorded. The quality assurance process for each of the three linacs were performed for the first 30 days. Within a 95% confidence interval, the overall uncertainty values for both translation and rotation were below 1.0 mm and 0.5° for each linac respectively. When combining the registration values and other uncertainties for all three linacs, the average deviations were within 2.0 mm and 1.0° of the designed translation and rotation offsets of the 3D print respectively. For all three linacs, the maximum total deviation for the Winston-Lutz test did not exceed 1.0 mm. Laser and light field verification was within tolerance every day for all three linacs given the latest guidance documentation for table repositioning. The 3D printer is capable of accurately fabricating a quality assurance phantom for 6DoF positioning verification. The end-to-end workflow allows for a more efficient test of the 6DoF mechanics while including other important tests needed for routine quality assurance. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  5. SU-E-T-234: Daily Quality Assurance for a Six Degrees of Freedom Couch Using a Novel Phantom

    Energy Technology Data Exchange (ETDEWEB)

    Woods, K; Woollard, J; Ayan, A; Sandu, A; Sommerfeld, J; Gupta, N [Ohio State Univ, Columbus, OH (United States); Laurel, A [Memorial Medical Center, Modesto, CA (United States)

    2015-06-15

    Purpose: To test the accuracy and reproducibility of both translational and rotational movements for a couch with six degrees of freedom (6DoF) using a novel phantom design Methods: An end-to-end test was carried out using two different phantoms. A 6 cm3 cube with a central fiducial BB (WL-QA Sun Nuclear) and a custom fabricated rectangular prism (31 cm x 8 cm x 8 cm), placed on a baseplate with known angular offsets for pitch, roll and yaw with a central fiducial BB and unique surface structures for registration purposes, were used. The end-to-end test included an initial CT simulation for a reference study, setup to an offset mark on each phantom, registration of the reference CT to the acquired cone-beam CT, and final Winston-Lutz delivery at four cardinal gantry angles. Results for both translational and rotational movements were recorded and compared for both phantoms. Results: Translational and rotational measurements were performed with a PerfectPitch (Varian) couch for 10 trials for both phantoms. Distinct translational shifts were [−5.372±0.384mm, −10.183±0.137mm, 14.028±0.155mm] for the cube and [7.520±0.159mm, −9.117±0.101mm, 16.273±0.115mm] for the prototype phantom for lateral, longitudinal, and vertical shifts, respectively. Distinct rotational adjustments were [1.121±0.102o, −1.067±0.235o, −2.662±0.380o] for the cube and [2.534±0.059o, 1.994±0.025o, 2.094±0.076o] for the prototype for pitch, roll, and yaw, respectively. Winston-Lutz test results performed after 6DoF couch correction from each cardinal gantry angle ranged from 0.26–0.72mm for the cube and 0.55–0.86mm for the prototype. Conclusion: The prototype phantom is more precise for both translational and rotational adjustments compared to a commercial phantom. The design of the prototype phantom allows for a more discernible visual confirmation of correct translational and rotational adjustments with the prototype phantom. Winston-Lutz results are more accurate for the

  6. Rainfall-Driven Diffusive Hydrograph and Runoff Model for Two Sub-Basins within the Arroyo Colorado in South Texas.

    Science.gov (United States)

    Ball, M. C.; Al-Qudah, O.; Jones, K.

    2017-12-01

    The Arroyo Colorado, located within the Rio Grande Valley of South Texas, has been on the list for the State of Texas's most impaired rivers since the 1990's. Few models for the watershed discharge and contaminates transport have been developed, but all require specialized understanding of modeling and input data which must either be assumed, estimated or which is difficult, time-consuming and expensive to collect. It makes sense to see if a general, simpler `catchment-scale' lumping model would be feasible to model water discharge along the Arroyo. Due to its simplicity and the hypothesized diffusive nature of the drainage in the alluvial floodplain deposits of the Arroyo watershed, the Criss and Winston model was chosen for this study. Hydrographs were characterized, clearly demonstrating that the discharge to the Arroyo is greatly affected by precipitation, and which provided clear rain events for evaluation: 62 rain events over a ten-year time span (2007 - 2017) were selected. Best fit curves using the Criss and Winston lag time were plotted, but better fitting curves were created by modifying the Criss and Winston lag time which improved the fit for the rising limb portion of the hydrograph but had no effect on the receding limb portion of the graph. This model provided some insights into the nature of water transport along the Arroyo within two separate sub-basins: El Fuste and Harlingen. The value for the apparent diffusivity constant "b", a constant which encompasses all diffusive characteristics of the watershed or sub-basins in the watershed (i.e. the lumping constant), was calculated to be 0.85 and 0.93 for El Fuste and Harlingen, respectively, indicating that each sub-basin within the watershed is somewhat unique. Due to the lumping nature of the "b" constant, no specific factor can be attributed to this difference. More research could provide additional insight. It is suggested that water diffusion takes longer in the Harlingen sub-basin (larger "b

  7. SU-E-J-48: Imaging Origin-Radiation Isocenter Coincidence for Linac-Based SRS with Novalis Tx

    International Nuclear Information System (INIS)

    Geraghty, C; Workie, D; Hasson, B

    2015-01-01

    Purpose To implement and evaluate an image-based Winston-Lutz (WL) test to measure the displacement between ExacTrac imaging origin and radiation isocenter on a Novalis Tx system using RIT V6.2 software analysis tools. Displacement between imaging and radiation isocenters was tracked over time. The method was applied for cone-based and MLC-based WL tests. Methods The Brainlab Winston-Lutz phantom was aligned to room lasers. The ExacTrac imaging system was then used to detect the Winston- Lutz phantom and obtain the displacement between the center of the phantom and the imaging origin. EPID images of the phantom were obtained at various gantry and couch angles and analyzed with RIT calculating the phantom center to radiation isocenter displacement. The RIT and Exactrac displacements were combined to calculate the displacement between imaging origin and radiation isocenter. Results were tracked over time. Results Mean displacements between ExacTrac origin and radiation isocenter were: VRT: −0.1mm ± 0.3mm, LNG: 0.5mm ± 0.2mm, LAT: 0.2mm ± 0.2mm (vector magnitude of 0.7 ± 0.2mm). Radiation isocenter was characterized by the mean of the standard deviations of the WL phantom displacements: σVRT: 0.2mm, σLNG: 0.4mm, σLAT: 0.6mm. The linac couch base was serviced to reduce couch walkout. This reduced σLAT to 0.2mm. These measurements established a new baseline of radiation isocenter-imaging origin coincidence. Conclusion The image-based WL test has ensured submillimeter localization accuracy using the ExacTrac imaging system. Standard deviations of ExacTrac-radiation isocenter displacements indicate that average agreement within 0.3mm is possible in each axis. This WL test is a departure from the tradiational WL in that imaging origin/radiation isocenter agreement is the end goal not lasers/radiation isocenter

  8. Teacher leadership in mathematics and science: Subject content knowledge and the improvement of instruction

    Science.gov (United States)

    Manno, Christopher M.

    This study explores the role of teacher leader subject content knowledge in the promotion of professional development and instructional reform. Consistent with a distributed leadership perspective, many have asserted that the promotion of school effectiveness can be enhanced through the application of teacher leadership (Frost & Durrant, 2003; Harris, 2002a; Sherrill, 1999; Silva, Gimbert, & Nolan, 2000; York-Barr & Duke, 2004). There has been much discussion in the research about the significance of teachers' subject content knowledge in teaching and learning which has generally asserted a positive relationship with instructional practice and student achievement (Darling-Hammond, 2000; Newton & Newton, 2001; Parker & Heywood, 2000). The role of content knowledge in teacher leader work has been less researched. This study focused on deepening understanding of perceptions regarding teacher leaders' roles in improving instructional practice. Based on a framework of common teacher leader tasks, qualitative methods were used to investigate the relationship between teacher leader subject content knowledge and perceptions of effectiveness in promoting professional development and instructional reform. The study indicates that content experts behave differently than their non-expert counterparts. Content experts recognize deficiencies in colleagues' content knowledge as a primary problem in the implementation of math or science reform. Content experts view their work as advocacy for improved curriculum and instruction for all children, and work within a small set of task categories to promote discussions about teaching, learning, and content. Content experts develop trust and rapport with colleagues by demonstrating expertise, and are respected for their deep knowledge and efforts to help teachers learn the content. They also differ from non-content experts in the professional growth experiences in which they engage. The consideration of content expertise as an influence

  9. The LIFE Cognition Study: design and baseline characteristics

    Directory of Open Access Journals (Sweden)

    Sink KM

    2014-08-01

    Full Text Available Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA; 4Pennington Biomedical, Louisiana State University, Baton Rouge, LA, USA; 5Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; 6Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA; 7Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 8Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, TX, USA; 9Klein Buendel, Inc., Golden, CO, USA; 10Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 11Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Observational studies have shown beneficial relationships between exercise and cognitive function. Some clinical trials have also demonstrated improvements in cognitive function in response to moderate–high intensity aerobic exercise; however, these have been limited by relatively small sample sizes and short durations. The Lifestyle Interventions and Independence for Elders (LIFE Study is the largest and longest randomized controlled clinical trial of physical activity with cognitive outcomes, in older sedentary

  10. Análise de redes sociais para configuração do layout de trabalho visando a transferência de conhecimento

    OpenAIRE

    Vanessa Becker Bertoni

    2016-01-01

    Os contextos em que as organizações operam e agem mudaram drasticamente nos últimos anos. Neste sentido, o espaço físico e a organização encontram-se conectados. As famosas palavras de Winston Churchill em 19431: “Nós moldamos nossos prédios e nossas construções nos moldam”, indiretamente já se referia à importância do espaço físico em relação a interação entre indivíduos. O design dos espaços de trabalho é normalmente guiado por topologias (formas de configurar layouts: aberto, fechado, celu...

  11. Europe from challenges of war towards challenges of peace

    Directory of Open Access Journals (Sweden)

    Fahredin Shabani

    2017-11-01

    Full Text Available The end of the WWII, did not bring peace and harmony among the peoples of Europe and World as expected. Enmity of the war time created such a deep ditch, which could not be overcome for a short time. What’s more, even among the allies-winners of the war, friendship and cooperation did not last too long. Very soon, two-three years after the end of the war, Europe was separated by an iron curtain, as Winston Churchill, the British prime minister would call it. The shadow of this division, first of all ideological, became known mostly in South Eastern European countries. This region, for about half of a century was seized by stalinism and democracy. Consequences of this division were not only political. Division produced economic and development consequences, which, in one or many ways, even nowadays, hinder this region in the European and Euro-Atlantic integration processes.

  12. Churchill and the United States of Europe, 1904-1948

    Directory of Open Access Journals (Sweden)

    Allen Packwood

    2016-12-01

    Full Text Available The call for a “United States of Europe” is a recurring theme in the writings and speeches of Sir Winston Churchill from at least 1930, and reaches its culmination in his opening address to the Congress of Europe held at The Hague in May 1948. This article analyses Churchill’s own writings and oratory to trace the origins of his support for closer European union. Initially he envisaged Britain as a guarantor and facilitator of European unity, but by 1948 he had become an advocate of a role for Britain within Europe. This shift in thinking is followed through analysis of his language and explained in terms of the historical context.

  13. The Impact of the Confiscation of the Turkish Dreadnoughts and of the Transfer of Goeben and Breslau to Constantinople upon the Turkish Entry into WWI

    Directory of Open Access Journals (Sweden)

    Heinz Richter

    2013-01-01

    Full Text Available When Winston Churchill then First Sealord of the Royal Navy had the two Dreanoughts, ordered and paid for by the Ottoman Empire before World War I, confiscated he created the preconditions for the Goeben-and Breslau-affair and the entry of Turkey into the war. This “act of piracy” (B. Tuchman shifted the weight from the so far stronger neutralists to the bellicists with in the Turkish Government towards war minister Enver. Without this mistake Goeben and Breslau would never have sought shelter in Turkey. And these two men of war were the reason for Turkey’s entry into the war when they bombarded Russian harbours in the Black Sea.

  14. Churchill, Europe and Turkey

    Directory of Open Access Journals (Sweden)

    Warren Dockter

    2016-12-01

    Full Text Available From the early 1930s until his peace time premiership (1951-1955, Winston Churchill was one of the strongest advocates of the concept of a United Europe. While this is well known among scholars of 20th century British history, Churchill’s actual vision for what a United Europe might look like has received less attention. Still less attention has been paid to Churchill’s opinions of the roles other nations might play within the new Europe. This article will examine Churchill’s view of Turkey in the new European order and will reveal that Churchill saw Turkey as a part of, (or at least an extension of Europe. However, this article will also reveal that Churchill’s conceptualisation of Turkey’s role was largely predicated on 19th century geostrategic thinking.

  15. The ascent of gravity the quest to understand the force that explains everything

    CERN Document Server

    Chown, Marcus

    2017-01-01

    Gravity is the weakest force in the everyday world yet it is the strongest force in the universe. It was the first force to be recognised and described yet it is the least understood. It is a 'force' that keeps your feet on the ground yet no such force actually exists. Gravity, to steal the words of Winston Churchill, is 'a riddle, wrapped in a mystery, inside an enigma'. And penetrating that enigma promises to answer the biggest questions in science: what is space? What is time? What is the universe? And where did it all come from? Award-winning writer Marcus Chown takes us on an unforgettable journey from the recognition of the 'force' of gravity in 1666 to the discovery of gravitational waves in 2015. And, as we stand on the brink of a seismic revolution in our worldview, he brings us up to speed on the greatest challenge ever to confront physics.

  16. Design of optimal and ideal 2-D concentrators with the collector immersed in a dielectric tube

    Science.gov (United States)

    Minano, J. C.; Ruiz, J. M.; Luque, A.

    1983-12-01

    A method is presented for designing ideal and optimal 2-D concentrators when the collector is placed inside a dielectric tube, for the particular case of a bifacial solar collector. The prototype 2-D (cylindrical geometry) concentrator is the compound parabolic concentrator or CPC, and from the beginning of development, it was found by Winston (1978) that filling up the concentrator with a transparent dielectric medium results in a big improvement of the optical properties. The method reported here is based on the extreme ray principle of design and avoids the use of differential equations by means of a proper appliction of Fermat's principle. One advantage of these concentrators is that they allow the size to be small compared with classical CPCs.

  17. Worry, problem elaboration and suppression of imagery: the role of concreteness.

    Science.gov (United States)

    Stöber, J

    1998-01-01

    Both lay concept and scientific theory claim that worry may be helpful for defining and analyzing problems. Recent studies, however, indicate that worrisome problem elaborations are less concrete than worry-free problem elaborations. This challenges the problem solving view of worry because abstract problem analyses are unlikely to lead to concrete problem solutions. Instead the findings support the avoidance theory of worry which claims that worry suppresses aversive imagery. Following research findings in the dual-coding framework [Paivio, A. (1971). Imagery and verbal processes. New York: Holt, Rhinehart and Winston; Paivio, A. (1986). Mental representations: a dual coding approach. New York: Oxford University Press.], the present article proposes that reduced concreteness may play a central role in the understanding of worry. First, reduced concreteness can explain how worry reduces imagery. Second, it offers an explanation why worrisome problem analyses are unlikely to arrive at solutions. Third, it provides a key for the understanding of worry maintenance.

  18. Quality assurance procedure for assessing mechanical accuracy of a radiation field center in stereotactic radiotherapy

    International Nuclear Information System (INIS)

    Tatsumi, Daisaku; Ienaga, Akinori; Nakada, Ryosei; Yomoda, Akane; Inoue, Makoto; Ichida, Takao; Hosono, Masako

    2012-01-01

    Stereotactic radiotherapy requires a quality assurance (QA) program that ensures the mechanical accuracy of a radiation field center. We have proposed a QA method for achieving the above requirement by conducting the Winston Lutz test using an electronic portal image device (EPID). An action limit was defined as three times the standard deviation. Then, the action limits for mean deviations of the radiation field center during collimator rotation, gantry rotation, and couch rotation in clockwise and counterclockwise resulted in 0.11 mm, 0.52 mm, 0.37 mm, and 0.41 mm respectively. Two years after the QA program was launched, the mean deviation of the radiation field center during gantry rotation exceeded the above action limit. Consequently, a mechanical adjustment for the gantry was performed, thereby restoring the accuracy of the radiation field center. A field center shift of 0.5 mm was also observed after a micro multi-leaf collimator was unmounted. (author)

  19. A Historical Review of R. J. Reynolds’ Strategies for Marketing Tobacco to Hispanics in the United States

    Science.gov (United States)

    Parascandola, Mark

    2013-01-01

    Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds’ marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February–July 2011 and April–August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities. PMID:23488493

  20. STS-87 Mission Specialist Scott poses in his launch and entry spacesuit at LC 39B during TCDT

    Science.gov (United States)

    1997-01-01

    STS-87 Mission Specialist Winston Scott poses in his orange launch and entry spacesuit with NASA suit technicians at Launch Pad 39B during Terminal Countdown Demonstration Test (TCDT) activities. The crew of the STS-87 mission is scheduled for launch Nov. 19 aboard the Space Shuttle Columbia. Scott will be performing an extravehicular activity (EVA) spacewalk during the mission. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

  1. Spellbinding and crooning: sound amplification, radio, and political rhetoric in international comparative perspective, 1900-1945.

    Science.gov (United States)

    Wijfjes, Huub

    2014-01-01

    This article researches in an interdisciplinary way the relationship of sound technology and political culture at the beginning of the twentieth century. It sketches the different strategies that politicians--Franklin D. Roosevelt, Adolf Hitler, Winston Churchill, and Dutch prime minister Hendrikus Colijn--found for the challenges that sound amplification and radio created for their rhetoric and presentation. Taking their different political styles into account, the article demonstrates that the interconnected technologies of sound amplification and radio forced a transition from a spellbinding style based on atmosphere and pathos in a virtual environment to "political crooning" that created artificial intimacy in despatialized simultaneity. Roosevelt and Colijn created the best examples of this political crooning, while Churchill and Hitler encountered problems in this respect. Churchill's radio successes profited from the special circumstances during the first period of World War II. Hitler's speeches were integrated into a radio regime trying to shape, with dictatorial powers, a national socialistic community of listeners.

  2. The wide-aperture gamma-ray telescope TAIGA-HiSCORE in the Tunka Valley: Design, composition and commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Gress, O., E-mail: grol08@rambler.ru [Institute of Applied Physics ISU, Irkutsk (Russian Federation); Astapov, I. [NRNU MEPhI, Moscow (Russian Federation); Budnev, N.; Bezyazeekov, P. [Institute of Applied Physics ISU, Irkutsk (Russian Federation); Bogdanov, A. [NRNU MEPhI, Moscow (Russian Federation); Boreyko, V. [JINR, Dubna (Russian Federation); Brückner, M. [Institute for Computer Science, Humboldt-University, Berlin (Germany); Chiavassa, A. [Dipartimento di Fisica Generale Universiteta di Torino and INFN, Torino (Italy); Chvalaev, O.; Dyachok, A.; Gress, T. [Institute of Applied Physics ISU, Irkutsk (Russian Federation); Epimakhov, S. [Institut fr Experimentalphysik, University of Hamburg (Germany); Fedoseev, E.; Gafarov, A. [Institute of Applied Physics ISU, Irkutsk (Russian Federation); Gorbunov, N.; Grebenyuk, V.; Grinuk, A. [JINR, Dubna (Russian Federation); Grishin, O. [Institute of Applied Physics ISU, Irkutsk (Russian Federation); Horns, D. [Institut fr Experimentalphysik, University of Hamburg (Germany); Ivanova, A. [Institute of Applied Physics ISU, Irkutsk (Russian Federation); and others

    2017-02-11

    The new TAIGA-HiSCORE non-imaging Cherenkov array aims to detect air showers induced by gamma rays above 30 TeV and to study cosmic rays above 100 TeV. TAIGA-HiSCORE is made of integrating air Cherenkov detector stations with a wide field of view (0.6 sr), placed at a distance of about 100 m. They cover an area of initially ∼0.25 km{sup 2} (prototype array), and of ∼5 km{sup 2} at the final phase of the experiment. Each station includes 4 PMTs with 20 or 25 cm diameter, equipped with light guides shaped as Winstone cones. We describe the design, specifications of the read-out, DAQ and control and monitoring systems of the array. The present 28 detector stations of the TAIGA-HiSCORE engineering setup are in operation since September 2015.

  3. Guidelines and Data to Support Plans for Reallocating Food during Crisis Relocation. Regional Appendix. FEMA Region IV,

    Science.gov (United States)

    1982-09-01

    STORES INC JACKSON MS 2 0 0 1 1 0 8,000 LEK:IS BEAR CO INC PFI;SAUOLA FL I 1 0 0 0 0 750 LEWIS cPCCER CO INDI , NOLA IS 2 1 1 0 0 0 2,2-ro MALONE AND...SON LEWIS GROCER CO INDI;’ NOLA MS . 0 0 0 0 0 3,000 M-.LONE AND HYDE INC MO.ROE LA I 0 I 0 0 0 1,500 COUNTY TOTAL: 3 0 3 0 0 0 4,500 WINSTON GCAVES CO...SIC’PES INC RALEIGH NC I 0 0 0 1 0 5.000 SMALL SUPPLIERS I I 0 0 0 0 750 CO’NITY TOTAL: 10 I 4 3 0 30,750 PENDER QUIN; WHOLESALE CO INC WARSAW NC 0 1 0 1

  4. Perceptions of the community on the pricing of community mental health services.

    Science.gov (United States)

    Ogden, J R; Ogden, D T

    1992-01-01

    In the past few years there has been a decrease in governmental support of Community Mental Health centers. Because of this, there has been some concern, on the part of Community Mental Health professionals, as to the overall impact of this decreased governmental support. Research has been conducted that speculates on how best to handle this mini-crisis. One article suggests moving to an overall marketing approach to help combat this dollar support decline (Day and Ford 1988). Others provide methods for surveying Community Mental Health users (Ludke, Curry & Saywell 1983). William Winston (1988) suggests an overall psychographic segmentation approach to developing market targets. There has also been research detailing promotional methods for expanded marketing coverage (Moldenhauer 1988), however little has been written defining the pricing impact on Community Mental Health services. This study addresses the perceptions of Community Mental Health Center users toward the price variable of the marketing mix.

  5. The Canadian cigar and tobacco journal in the forties: a remembrance.

    Science.gov (United States)

    Warsh, Cheryl Krasnick

    2006-01-01

    This paper is a period snapshot of the life and times of Canadian smoking culture, filtered through "The Canadian Cigar and Tobacco Journal" (the industry's trade paper) from 1943-1949. "The Journal" provided a vivid portrait of neighbourhood tobacconists, travelling salesman, wholesalers and factory workers, homemakers and entrepreneurs. I discuss the role of Jews in the industry, as manufacturers and retailers. "The Journal" evokes the dangers of the retail trade, such as armed robberies, as well as the dangers of wartime. There is also the parallel danger of tobacco smoking, which, although not explicitly defined as risky behaviour by physicians, nonetheless is apparent to consumers. World War II is a dominant feature of "The Journal," and the celebration of wartime tobacco consumption is epitomized by Winston Churchill and other heroic smokers. Women's increased economic participation during the war years, and postwar demobilization, is reflected in "The Journal." Finally I discuss the growing targeting of children as potential consumers of tobacco.

  6. A historical review of R.J. Reynolds' strategies for marketing tobacco to Hispanics in the United States.

    Science.gov (United States)

    Iglesias-Rios, Lisbeth; Parascandola, Mark

    2013-05-01

    Hispanics are the fastest growing racial/ethnic group in the United States, and smoking is the leading preventable cause of morbidity and mortality among this population. We analyzed tobacco industry documents on R. J. Reynolds' marketing strategies toward the Hispanic population using tobacco industry document archives from the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February-July 2011 and April-August 2012. Our analysis revealed that by 1980 the company had developed a sophisticated surveillance system to track the market behavior of Hispanic smokers and understand their psychographics, cultural values, and attitudes. This information was translated into targeted marketing campaigns for the Winston and Camel brands. Marketing targeted toward Hispanics appealed to values and sponsored activities that could be perceived as legitimating. Greater understanding of tobacco industry marketing strategies has substantial relevance for addressing tobacco-related health disparities.

  7. The Idaho Spent Fuel Project Update-January, 2003

    International Nuclear Information System (INIS)

    Roberts, R.; Tulberg, D.; Carter, C.

    2003-01-01

    The Department of Energy awarded a privatized contract to Foster Wheeler Environmental Corporation in May 2000 for the design, licensing, construction and operation of a spent nuclear fuel repackaging and storage facility. The Foster Wheeler Environmental Team consists of Foster Wheeler Environmental Corp. (the primary contractor), Alstec, RWE-Nukem, RIO Technical Services, Winston and Strawn, and Utility Engineering. The Idaho Spent Fuel (ISF) facility is an integral part of the DOE-EM approach to accelerating SNF disposition at the Idaho National Engineering and Environmental Laboratory (INEEL). Construction of this facility is also important in helping DOE to meet the provisions of the Idaho Settlement Agreement. The ISF Facility is a substantial facility with heavy shielding walls in the repackaging and storage bays and state-of-the-art features required to meet the provisions of 10 CFR 72 requirements. The facility is designed for a 40-year life

  8. STS-72 Flight Day 2

    Science.gov (United States)

    1996-01-01

    On this second day of the STS-72 mission, the flight crew, Cmdr. Brian Duffy, Pilot Brent W. Jett, and Mission Specialists Leroy Chiao, Daniel T. Barry, Winston E. Scott, and Koichi Wakata (NASDA), awakened to music from the motion picture 'Star Wars.' The crew performed a systems checkout, prepared for the retrieval of the Japanese Space Flyer Unit (SFU), tested the spacesuits for the EVA, and activated some of the secondary experiments. An in-orbit news interview was conducted with the crew via satellite downlinking. Questions asked ranged from the logistics of the mission to the avoidance procedures the Endeavour Orbiter performed to miss hitting the inactive Air Force satellite, nicknamed 'Misty' (MSTI). Earth views included cloud cover, several storm systems, and various land masses with several views of the shuttle's open cargo bay in the foreground.

  9. ES12; The 24th Annual Workshop on Recent Developments in Electronic Structure Theory

    Energy Technology Data Exchange (ETDEWEB)

    Holzwarth, Natalie [Wake Forest Univ., Winston-Salem, NC (United States); Thonhauser, Timo [Wake Forest Univ., Winston-Salem, NC (United States); Salam, Akbar [Wake Forest Univ., Winston-Salem, NC (United States)

    2012-06-29

    ES12: The 24th Annual Workshop on Recent Developments in Electronic Structure Theory was held June 5-8, 2012 at Wake Forest University in Winston-Salem, NC 27109. The program consisted of 24 oral presentations, 70 posters, and 2 panel discussions. The attendance of the Workshop was comparable to or larger than previous workshops and participation was impressively diverse. The 136 participants came from all over the world and included undergraduate students, graduate students, postdoctoral researchers, and senior scientists. The general assessment of the Workshop was extremely positive in terms of the high level of scientific presentations and discussions, and in terms of the schedule, accommodations, and affordability of the meeting.

  10. The future of meat: a qualitative analysis of cultured meat media coverage.

    Science.gov (United States)

    Goodwin, J N; Shoulders, C W

    2013-11-01

    This study sought to explore the informational themes and information sources cited by the media to cover stories of cultured meat in both the United States and the European Union. The results indicated that cultured meat news articles in both the United States and the European Union commonly discuss cultured meat in terms of benefits, history, process, time, livestock production problems, and skepticism. Additionally, the information sources commonly cited in the articles included cultured meat researchers, sources from academia, People for the Ethical Treatment of Animals (PETA), New Harvest, Winston Churchill, restaurant owners/chefs, and sources from the opposing countries (e.g. US use some EU sources and vice versa). The implications of this study will allow meat scientists to understand how the media is influencing consumers' perceptions about the topic, and also allow them to strategize how to shape future communication about cultured meat. Published by Elsevier Ltd.

  11. Analysis of compound parabolic concentrators and aperture averaging to mitigate fading on free-space optical links

    Science.gov (United States)

    Wasiczko, Linda M.; Smolyaninov, Igor I.; Davis, Christopher C.

    2004-01-01

    Free space optics (FSO) is one solution to the bandwidth bottleneck resulting from increased demand for broadband access. It is well known that atmospheric turbulence distorts the wavefront of a laser beam propagating through the atmosphere. This research investigates methods of reducing the effects of intensity scintillation and beam wander on the performance of free space optical communication systems, by characterizing system enhancement using either aperture averaging techniques or nonimaging optics. Compound Parabolic Concentrators, nonimaging optics made famous by Winston and Welford, are inexpensive elements that may be easily integrated into intensity modulation-direct detection receivers to reduce fading caused by beam wander and spot breakup in the focal plane. Aperture averaging provides a methodology to show the improvement of a given receiver aperture diameter in averaging out the optical scintillations over the received wavefront.

  12. Design of three-dimensional nonimaging concentrators with inhomogeneous media

    Science.gov (United States)

    Minano, J. C.

    1986-09-01

    A three-dimensional nonimaging concentrator is an optical system that transforms a given four-parametric manifold of rays reaching a surface (entry aperture) into another four-parametric manifold of rays reaching the receiver. A procedure of design of such concentrators is developed. In general, the concentrators use mirrors and inhomogeneous media (i.e., gradient-index media). The concentrator has the maximum concentration allowed by the theorem of conservation of phase-space volume. This is the first known concentrator with such properties. The Welford-Winston edge-ray principle in three-dimensional geometry is proven under several assumptions. The linear compound parabolic concentrator is derived as a particular case of the procedure of design.

  13. Towards a wider dialogue

    CERN Multimedia

    2012-01-01

    This week, I had the rewarding experience of taking part in a Wilton Park meeting examining three very different world-views: science, philosophy and theology. Wilton Park describes itself as a forum for analysing and advancing the agenda on global policy challenges, and over the years it has developed an enviable reputation for delivering authoritative reports drawn from bringing international experts together under the same roof for two days to discuss issues of topical relevance.   Participation is by invitation and there are no observers: everyone is there because they have something to bring to the discussion. Wilton Park reports always have their finger on the zeitgeist, appropriately, perhaps, for an institution born of Winston Churchill’s vision for reconciliation and dialogue in post-war Europe. When I learned that Wilton Park was running a series of meetings examining the role of religion in modern society, and that it was looking at the possibility of holding an event in...

  14. Association of Geography and Ambient Air Pollution with Urine Metal Concentrations in Six US Cities: The Multi-Ethnic Study of Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Yuanjie Pang

    2016-03-01

    Full Text Available We investigated the associations of urinary concentrations of antimony, cadmium, tungsten and uranium with geographic locations and with ambient air pollution in 304 adults in the Multi-Ethnic Study of Atherosclerosis from six US cities. After adjustment for sociodemographics, body mass index, and smoking status, urinary cadmium was the highest in Winston-Salem among all study sites (the geometric mean [GM] in Winston-Salem was 0.84 µg/L [95% confidence interval (CI 0.57–1.22]. The adjusted GMs of urinary tungsten and uranium were highest in Los Angeles (0.11 µg/L [95% CI 0.08–0.16] and 0.019 µg/L [95% CI 0.016–0.023], respectively. The adjusted GM ratio comparing fine particulate matter (PM2.5 tertiles 2 and 3 with the lowest tertile were 1.64 (95% CI 1.05–2.56 and 3.55 (95% CI 2.24–5.63 for tungsten, and 1.18 (95% CI 0.94–1.48 and 1.70 (95% CI 1.34–2.14 for uranium. The results for tungsten remained similar after adjustment for study site. Urinary cadmium, tungsten and uranium concentrations differed by geographic locations in MESA (Multi-Ethnic Study of Atherosclerosis communities. PM2.5 levels could contribute to geographic differences in tungsten exposure. These findings highlight the need to implement preventive strategies to decrease toxic metal exposure and to evaluate the health effects of chronic exposure to those metals.

  15. Victory Gin Lane. Starvation and Beverages in Orwell’s Nineteen Eighty-Four

    Directory of Open Access Journals (Sweden)

    Paolo Caponi

    2015-05-01

    Full Text Available Gin is an ubiquitous presence in the domestic and urban scenery of Nineteen Eighty-Four (1949. For a population mercilessly hungered, it represents a handy and cheap commodity item providing a fluid opportunity for social aggregation. Victory Gin, served “in handless chine mugs” (53, is part of the workers’ staple diet at the Ministry of Truth, and is sold “at ten cents the large nip” from the small bar (actually, “a mere hole in the wall”, 51 in the canteen; served with cloves, it is the “speciality” (79 of that disreputable place which is the Chestnut Tree Café, where Winston Smith once spotted three fallen-out-of-favor members of the Inner Party – Jones, Aaronson and Rutherford – drink it silently after their release from Oceania prison camps (79. As is typical of the fate of spirits in literature, gin also serves as self-medication and can fuel a kind of inner escapism. It is to make the world “look more cheerful” that Winston gulps it down “like a dose of medicine”, and only after the “shock” of swallowing it can he squeeze himself into his alcove and begin his diary (7; gin clears out Winston’s stomach (53, and is the ultima ratio against that prescient “dull ache” in his belly (105; 106 that originates after bumping into “the girl with dark hair” (later: Julia one evening outside Mr. Charrington’s shop.

  16. SU-E-T-373: A Motorized Stage for Fast and Accurate QA of Machine Isocenter

    International Nuclear Information System (INIS)

    Moore, J; Velarde, E; Wong, J

    2014-01-01

    Purpose: Precision delivery of radiation dose relies on accurate knowledge of the machine isocenter under a variety of machine motions. This is typically determined by performing a Winston-Lutz test consisting of imaging a known object at multiple gantry/collimator/table angles and ensuring that the maximum offset is within specified tolerance. The first step in the Winston-Lutz test is careful placement of a ball bearing at the machine isocenter as determined by repeated imaging and shifting until accurate placement has been determined. Conventionally this is performed by adjusting a stage manually using vernier scales which carry the limitation that each adjustment must be done inside the treatment room with the risks of inaccurate adjustment of the scale and physical bumping of the table. It is proposed to use a motorized system controlled outside of the room to improve the required time and accuracy of these tests. Methods: The three dimensional vernier scales are replaced by three motors with accuracy of 1 micron and a range of 25.4mm connected via USB to a computer in the control room. Software is designed which automatically detects the motors and assigns them to proper axes and allows for small shifts to be entered and performed. Input values match calculated offsets in magnitude and sign to reduce conversion errors. Speed of setup, number of iterations to setup, and accuracy of final placement are assessed. Results: Automatic BB placement required 2.25 iterations and 13 minutes on average while manual placement required 3.76 iterations and 37.5 minutes. The average final XYZ offsets is 0.02cm, 0.01cm, 0.04cm for automatic setup and 0.04cm, 0.02cm, 0.04cm for manual setup. Conclusion: Automatic placement decreased time and repeat iterations for setup while improving placement accuracy. Automatic placement greatly reduces the time required to perform QA

  17. Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan

    Directory of Open Access Journals (Sweden)

    Varagic J

    2014-11-01

    Full Text Available Jasmina Varagic,1–3 Henry Punzi,4,5 Carlos M Ferrario2,3,61Hypertension and Vascular Research Center, 2Division of Surgical Sciences, 3Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC USA; 4Trinity Hypertension and Diagnostic Research Center, Carrollton, TX, USA; 5Department of Family and Community Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; 6Department of Internal Medicine and Nephrology, Wake Forest University, Winston-Salem, NC, USAAbstract: Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titrated single agents, and to increase persistence and adherence with antihypertensive therapy. Multiple clinical trials provide evidence that fixed-dose combinations in a single pill offer several advantages when compared with loose-dose combinations. This review discusses the advances in hypertension control and associated cardiovascular disease as they relate to the prospect of combination therapy targeting a third-generation beta (β 1-adrenergic receptor (nebivolol and an angiotensin II receptor blocker (valsartan in fixed-dose single-pill formulations.Keywords: blood pressure control, hypertension, β1-adrenergic receptor, renin angiotensin system

  18. Lennox–Gastaut syndrome: impact on the caregivers and families of patients

    Directory of Open Access Journals (Sweden)

    Gibson PA

    2014-10-01

    Full Text Available Patricia A Gibson Epilepsy Information Service, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Lennox–Gastaut syndrome (LGS has a major impact on the health-related quality of life (HRQL of the affected children as well as their caregivers. The primary caregiver in the family is generally the mother, with support from the father and siblings. The burden of care and the effects of the disease on the child necessitate adjustments in virtually all aspects of the lives of their family. These adjustments inevitably affect the physical, emotional, social, and financial health of the whole family. Numerous sources of support for families can help to ease the burden of care. Improvements in the treatment of LGS, in addition to helping the child with LGS, would likely help improve the HRQL of the family members. This pilot parent survey was designed to explore the impact of epilepsy on caregiver HRQL. Parents of children with epilepsy who had contacted the Epilepsy Information Service at the Wake Forest University School of Medicine, Winston-Salem, NC, USA, were sent questionnaires comprising open- and closed-ended questions. A total of 200 surveys were distributed, with a return rate of 48%. The results revealed that 74% of the parents believed that having a child with epilepsy brought them and their partner closer together. However, when the parents were asked to explain the manner in which epilepsy affected their families, answers included continuous stress, major financial distress, and lack of time to spend with other children. Information and resources for the families of children with LGS could help improve the HRQL of both the patients and their relatives. Keywords: health-related quality of life, HRQL, epilepsy, relatives, siblings

  19. Land Use Adaptation to Climate Change: Economic Damages from Land-Falling Hurricanes in the Atlantic and Gulf States of the USA, 1900–2005

    Directory of Open Access Journals (Sweden)

    Asim Zia

    2012-05-01

    Full Text Available Global climate change, especially the phenomena of global warming, is expected to increase the intensity of land-falling hurricanes. Societal adaptation is needed to reduce vulnerability from increasingly intense hurricanes. This study quantifies the adaptation effects of potentially policy driven caps on housing densities and agricultural cover in coastal (and adjacent inland areas vulnerable to hurricane damages in the Atlantic and Gulf Coastal regions of the U.S. Time series regressions, especially Prais-Winston and Autoregressive Moving Average (ARMA models, are estimated to forecast the economic impacts of hurricanes of varying intensity, given that various patterns of land use emerge in the Atlantic and Gulf coastal states of the U.S. The Prais-Winston and ARMA models use observed time series data from 1900 to 2005 for inflation adjusted hurricane damages and socio-economic and land-use data in the coastal or inland regions where hurricanes caused those damages. The results from this study provide evidence that increases in housing density and agricultural cover cause significant rise in the de-trended inflation-adjusted damages. Further, higher intensity and frequency of land-falling hurricanes also significantly increase the economic damages. The evidence from this study implies that a medium to long term land use adaptation in the form of capping housing density and agricultural cover in the coastal (and adjacent inland states can significantly reduce economic damages from intense hurricanes. Future studies must compare the benefits of such land use adaptation policies against the costs of development controls implied in housing density caps and agricultural land cover reductions.

  20. WE-G-BRA-02: SafetyNet: Automating Radiotherapy QA with An Event Driven Framework

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, S; Kessler, M [The University of Michigan, Ann Arbor, MI (United States); Litzenberg, D [Univ Michigan, Ann Arbor, MI (United States); Lee, C; Irrer, J; Chen, X; Acosta, E; Weyburne, G; Lam, K; Younge, K; Matuszak, M [University of Michigan, Ann Arbor, MI (United States); Keranen, W [Varian Medical Systems, Palo Alto, CA (United States); Covington, E [University of Michigan Hospital and Health System, Ann Arbor, MI (United States); Moran, J [Univ Michigan Medical Center, Ann Arbor, MI (United States)

    2015-06-15

    Purpose: Quality assurance is an essential task in radiotherapy that often requires many manual tasks. We investigate the use of an event driven framework in conjunction with software agents to automate QA and eliminate wait times. Methods: An in house developed subscription-publication service, EventNet, was added to the Aria OIS to be a message broker for critical events occurring in the OIS and software agents. Software agents operate without user intervention and perform critical QA steps. The results of the QA are documented and the resulting event is generated and passed back to EventNet. Users can subscribe to those events and receive messages based on custom filters designed to send passing or failing results to physicists or dosimetrists. Agents were developed to expedite the following QA tasks: Plan Revision, Plan 2nd Check, SRS Winston-Lutz isocenter, Treatment History Audit, Treatment Machine Configuration. Results: Plan approval in the Aria OIS was used as the event trigger for plan revision QA and Plan 2nd check agents. The agents pulled the plan data, executed the prescribed QA, stored the results and updated EventNet for publication. The Winston Lutz agent reduced QA time from 20 minutes to 4 minutes and provided a more accurate quantitative estimate of radiation isocenter. The Treatment Machine Configuration agent automatically reports any changes to the Treatment machine or HDR unit configuration. The agents are reliable, act immediately, and execute each task identically every time. Conclusion: An event driven framework has inverted the data chase in our radiotherapy QA process. Rather than have dosimetrists and physicists push data to QA software and pull results back into the OIS, the software agents perform these steps immediately upon receiving the sentinel events from EventNet. Mr Keranen is an employee of Varian Medical Systems. Dr. Moran’s institution receives research support for her effort for a linear accelerator QA project from

  1. Studying the clinical encounter with the Adaptive Leadership framework

    Directory of Open Access Journals (Sweden)

    Bailey Jr DE

    2012-08-01

    Full Text Available Donald E Bailey Jr,1,2 Sharron L Docherty,1 Judith A Adams,1 Dana L Carthron,3 Kirsten Corazzini,1,2 Jennifer R Day,1 Elizabeth Neglia,1 Marcus Thygeson,4 Ruth A Anderson1,21School of Nursing, Duke University, 2Center for the Study of Aging and Human Development, Duke University, Durham, NC, 3School of Health Science, Division of Nursing, Winston Salem State University, Winston Salem, NC, 4Medical Services, Blue Shield of California, San Francisco, CA, USAAbstract: In this paper we discuss the concept of leadership as a personal capability, not contingent on one's position in a hierarchy. This type of leadership allows us to reframe both the care-giving and organizational roles of nurses and other front-line clinical staff. Little research has been done to explore what leadership means at the point of care, particularly in reference to the relationship between health care practitioners and patients and their family caregivers. The Adaptive Leadership framework, based on complexity science theory, provides a useful lens to explore practitioners' leadership behaviors at the point of care. This framework proposes that there are two broad categories of challenges that patients face: technical and adaptive. Whereas technical challenges are addressed with technical solutions that are delivered by practitioners, adaptive challenges require the patient (or family member to adjust to a new situation and to do the work of adapting, learning, and behavior change. Adaptive leadership is the work that practitioners do to mobilize and support patients to do the adaptive work. The purpose of this paper is to describe this framework and demonstrate its application to nursing research. We demonstrate the framework's utility with five exemplars of nursing research problems that range from the individual to the system levels. The framework has the potential to guide researchers to ask new questions and to gain new insights into how practitioners interact with

  2. WE-G-BRA-02: SafetyNet: Automating Radiotherapy QA with An Event Driven Framework

    International Nuclear Information System (INIS)

    Hadley, S; Kessler, M; Litzenberg, D; Lee, C; Irrer, J; Chen, X; Acosta, E; Weyburne, G; Lam, K; Younge, K; Matuszak, M; Keranen, W; Covington, E; Moran, J

    2015-01-01

    Purpose: Quality assurance is an essential task in radiotherapy that often requires many manual tasks. We investigate the use of an event driven framework in conjunction with software agents to automate QA and eliminate wait times. Methods: An in house developed subscription-publication service, EventNet, was added to the Aria OIS to be a message broker for critical events occurring in the OIS and software agents. Software agents operate without user intervention and perform critical QA steps. The results of the QA are documented and the resulting event is generated and passed back to EventNet. Users can subscribe to those events and receive messages based on custom filters designed to send passing or failing results to physicists or dosimetrists. Agents were developed to expedite the following QA tasks: Plan Revision, Plan 2nd Check, SRS Winston-Lutz isocenter, Treatment History Audit, Treatment Machine Configuration. Results: Plan approval in the Aria OIS was used as the event trigger for plan revision QA and Plan 2nd check agents. The agents pulled the plan data, executed the prescribed QA, stored the results and updated EventNet for publication. The Winston Lutz agent reduced QA time from 20 minutes to 4 minutes and provided a more accurate quantitative estimate of radiation isocenter. The Treatment Machine Configuration agent automatically reports any changes to the Treatment machine or HDR unit configuration. The agents are reliable, act immediately, and execute each task identically every time. Conclusion: An event driven framework has inverted the data chase in our radiotherapy QA process. Rather than have dosimetrists and physicists push data to QA software and pull results back into the OIS, the software agents perform these steps immediately upon receiving the sentinel events from EventNet. Mr Keranen is an employee of Varian Medical Systems. Dr. Moran’s institution receives research support for her effort for a linear accelerator QA project from

  3. Enhancing mHealth Technology in the Patient-Centered Medical Home Environment to Activate Patients With Type 2 Diabetes: A Multisite Feasibility Study Protocol.

    Science.gov (United States)

    Gimbel, Ronald; Shi, Lu; Williams, Joel E; Dye, Cheryl J; Chen, Liwei; Crawford, Paul; Shry, Eric A; Griffin, Sarah F; Jones, Karyn O; Sherrill, Windsor W; Truong, Khoa; Little, Jeanette R; Edwards, Karen W; Hing, Marie; Moss, Jennie B

    2017-03-06

    Diabetes Self-care Activities Measure scores, clinical measures, comorbid conditions, health services resource consumption, and technology system usage statistics. We have completed phase 1 data collection. Formal analysis of phase 1 data has not been completed. We have obtained institutional review board approval and began phase 1 research in late fall 2016. The study hypotheses suggest that patients can, and will, improve their activation in chronic care management. Improved activation should translate into improved diabetes self-care. Expected benefits of this research to the scientific community and health care services include improved understanding of how to leverage mHealth technology to activate patients living with type 2 diabetes in self-management behaviors. The research will shed light on implementation strategies in integrating mHealth into the clinical workflow of the PCMH setting. ClinicalTrials.gov NCT02949037. https://clinicaltrials.gov/ct2/show/NCT02949037. (Archived by WebCite at http://www.webcitation.org/6oRyDzqei). ©Ronald Gimbel, Lu Shi, Joel E Williams, Cheryl J Dye, Liwei Chen, Paul Crawford, Eric A Shry, Sarah F Griffin, Karyn O Jones, Windsor W Sherrill, Khoa Truong, Jeanette R Little, Karen W Edwards, Marie Hing, Jennie B Moss. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 06.03.2017.

  4. Hydrogen and oxygen isotope constraints on hydrothermal alteration of the Trinity peridotite, Klamath Mountains, California

    Science.gov (United States)

    Liakhovitch, V.; Quick, J.E.; Gregory, R.T.

    2005-01-01

    The Trinity peridotite represents a rare opportunity to examine a relatively fertile plagioclase peridotite that was exhumed and later subjected to intrusive events in a seafloor environment, followed by its emplacement and incorporation into a continent. Over 250 stable isotopic determinations on whole rocks and minerals elucidate the hydrothermal evolution of the Trinity complex. All three serpentine polymorphs are present in the Trinity peridotite; these separate on the basis of their ??D values: antigorite, -46 serpentinization, or overprinting of earlier low-temperature seafloor serpentinization. Regionally, contours of ??D values exhibit bull's-eye patterns associated with the gabbroic plutons, with ??D maxima coinciding with the blackwall alteration at the margins on the plutons. In contrast to the hydrogen isotope behavior, oxygen isotope values of the three polymorphs are indistinguishable, spanning the range 5.3 history: (1) lithospheric emplacement and cooling of the peridotite in an oceanic environment ??? 472 Ma; (2) intrusion of gabbroic plutons into cold peridotite in an arc environment between 435 and 404 Ma; and finally (3) intrusion of felsic plutons between 171 and 127 Ma, long after the peridotite was incorporated into the continental crust. Copyright ?? 2005 by V. H. Winston & Son, Inc. All rights reserved.

  5. Pulsed Electromagnetic Acceleration of Plasma: A Review

    Science.gov (United States)

    Thio, Y. C. Francis; Turchi, Peter J.; Markusic, Thomas E.; Cassibry, Jason T.; Sommer, James; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    Much have been learned in the acceleration mechanisms involved in accelerating a plasma electromagnetically in the laboratory over the last 40 years since the early review by Winston Bostik of 1963, but the accumulated understanding is very much scattered throughout the literature. This literature extends back at least to the early sixties and includes Rosenbluth's snowplow model, discussions by Ralph Lovberg, Colgate's boundary-layer model of a current sheet, many papers from the activity at Columbia by Robert Gross and his colleagues, and the relevant, 1-D unsteady descriptions developed from the U. of Maryland theta-pinch studies. Recent progress on the understanding of the pulsed penetration of magnetic fields into collisionless or nearly collisionless plasmas are also be reviewed. Somewhat more recently, we have the two-dimensional, unsteady results in the collisional regime associated with so-called wall-instability in large radius pinch discharges and also in coaxial plasma guns (e.g., Plasma Flow Switch). Among other things, for example, we have the phenomenon of a high- density plasma discharge propagating in a cooaxial gun as an apparently straight sheet (vs paraboloid) because mass re-distribution (on a microsecond timescale) compensates for the 1/r- squared variation of magnetic pressure. We will attempt to collate some of this vast material and bring some coherence tc the development of the subject.

  6. The association of age of toilet training and dysfunctional voiding

    Directory of Open Access Journals (Sweden)

    Hodges SJ

    2014-10-01

    Full Text Available Steve J Hodges, Kyle A Richards, Ilya Gorbachinsky, L Spencer KraneDepartment of Urology, Wake Forest University, Winston-Salem, NC, USAObjective: To determine whether age of toilet training is associated with dysfunctional voiding in children.Materials and methods: We compared patients referred to the urologic clinics for voiding dysfunction with age-matched controls without urinary complaints. Characteristics including age and reason for toilet training, method of training, and encopresis or constipation were compared between both groups.Results: Initiation of toilet training prior to 24 months and later than 36 months of age were associated with dysfunctional voiding. However, dysfunctional voiding due to late toilet training was also associated with constipation.Conclusion: Dysfunctional voiding may be due to delayed emptying of the bowel and bladder by children. The symptoms of dysfunctional voiding are more common when toilet training early, as immature children may be less likely to empty in a timely manner, or when training late due to (or in association with constipation.Keywords: voiding dysfunction, constipation

  7. Noncoding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment

    Directory of Open Access Journals (Sweden)

    Samantha eBarichievy

    2015-03-01

    Full Text Available On October 28th 1943 Winston Churchill said we shape our buildings, and afterwards our buildings shape us (Humes, 1994. Churchill was pondering how and when to rebuild the British House of Commons, which had been destroyed by enemy bombs on May 10th 1941. The old House had been small and insufficient to hold all its members, but was restored to its original form in 1950 in order to recapture the convenience and dignity that the building had shaped into its parliamentary members. The circular loop whereby buildings or dwellings are shaped and go on to shape those that reside in them is also true of pathogens and their hosts. As obligate parasites, pathogens need to alter their cellular host environments to ensure survival. Typically pathogens modify cellular transcription profiles and in doing so, the pathogen in turn is affected, thereby closing the loop. As key orchestrators of gene expression, noncoding RNAs provide a vast and extremely precise set of tools for pathogens to target in order to shape the cellular environment. This review will focus on host noncoding RNAs that are manipulated by the infamous intracellular pathogen, the Human Immunodeficiency Virus (HIV. We will briefly describe both short and long host noncoding RNAs and discuss how HIV gains control of these factors to ensure widespread dissemination throughout the host as well as the establishment of lifelong, chronic infection.

  8. Significance of international hydropower storages for the German energy turnaround; Bedeutung der internationalen Wasserkraftspeicherung fuer die deutsche Energiewende

    Energy Technology Data Exchange (ETDEWEB)

    Hobohm, Jens; Ess, Florian [Prognos AG, Berlin (Germany)

    2013-01-15

    Prediction is very difficult, especially if it's about the future. This witticism, which has been alternatively ascribed to Mark Twain, Karl Valentin, Niels Bohr and Winston Churchill, could hardly be truer than when applied to the wind and sun, especially in the case of long-term forecasts. Wind power and photovoltaic plant capacities are what needs to grow most if renewable energies really are to cover 80% of Germany's energy supply by the year 2050. Other renewable energy resources do not have the potential to contribute substantially to achieving the goals proclaimed by the German federal government. Some 64% of electricity production and 70% of installed power capacity will be coming from the wind and sun in the year 2050, according to recent calculations. A study prepared by Prognos AG on behalf of the German National Committee of the World Energy Council has investigated the question as to what extent international hydropower storages are capable of taking up surplus electricity and holding it available as a power reserve.

  9. The strokes that killed Churchill, Roosevelt, and Stalin.

    Science.gov (United States)

    Ali, Rohaid; Connolly, Ian D; Li, Amy; Choudhri, Omar A; Pendharkar, Arjun V; Steinberg, Gary K

    2016-07-01

    From February 4 to 11, 1945, President Franklin D. Roosevelt of the United States, Soviet Union Premier Joseph Stalin, and British Prime Minister Winston Churchill met near Yalta in Crimea to discuss how post-World War II (WWII) Europe should be organized. Within 2 decades of this conference, all 3 men had died. President Roosevelt died 2 months after the Yalta Conference due to a hemorrhagic stroke. Premier Stalin died 8 years later, also due to a hemorrhagic stroke. Finally, Prime Minister Churchill died 20 years after the conference because of complications due to stroke. At the time of Yalta, these 3 men were the leaders of the most powerful countries in the world. The subsequent deterioration of their health and eventual death had varying degrees of historical significance. Churchill's illness forced him to resign as British prime minister, and the events that unfolded immediately after his resignation included Britain's mismanagement of the Egyptian Suez Crisis and also a period of mistrust with the United States. Furthermore, Roosevelt was still president and Stalin was still premier at their times of passing, so their deaths carried huge political ramifications not only for their respective countries but also for international relations. The early death of Roosevelt, in particular, may have exacerbated post-WWII miscommunication between America and the Soviet Union-miscommunication that may have helped precipitate the Cold War.

  10. Emerging role of rasburicase in the management of increased plasma uric acid levels in patients with hematologic malignancies

    Directory of Open Access Journals (Sweden)

    LeAnne D Kennedy

    2011-02-01

    Full Text Available LeAnne D Kennedy1 Susannah Koontz2 Kamakshi Rao31Wake Forest University Baptist Medical Center, Winston Salem, NC, USA; 2Koontz Oncology Consulting LLC, Houston, TX, USA; 3UNC Hospitals, Chapel Hill, NC, USAAbstract: Tumor lysis syndrome (TLS is defined as a group of metabolic derangements that result from the massive and abrupt release of cellular components into the bloodstream after rapid lysis of tumor cells. Breakdown of released materials leads to a number of electrolyte abnormalities, including elevated uric acid concentrations in the blood (hyperuricemia, which carries potentially serious consequences. The diagnosis, prevention, and management of TLS is complicated by variability in definitions, differences in risk factors based on patient- and tumor-specific characteristics, and practitioner preferences in terms of pharmaceutical management strategies. The best prevention and management option for a particular patient depends on the patient’s baseline risk for TLS development, the severity of symptoms in the event of TLS development, practical management considerations, and financial implications of treatment.Keywords: tumor lysis syndrome, uric acid, rasburicase

  11. Quality of life issues and measurement in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Tan X

    2012-02-01

    Full Text Available Xi Tan1, Steven R Feldman2, Rajesh Balkrishnan11Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 2Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract: Psoriasis is a chronic immunologic disease characterized by red papules and plaques with a silver colored scale. The impact of psoriasis on patients’ overall quality of life is significant, broad, and deep, including effects on emotional wellbeing, psychological stress, self-esteem, relationship, work, social activities, financial burden, and even physical function. Although there are various measures available for assessing health-related quality of life (HRQoL in research studies, there is no consensus on which measure is best to use in clinical practice or for research comparing different treatments. Choosing treatments based on patients’ specific individual preferences, goal-orientation, and close, attentive cooperation between patients and their doctors may be an effective strategy that can be applied to improve patients’ quality of life.Keywords: treatment, health related quality of life, HRQoL

  12. Hard disks with SCSI interface

    CERN Document Server

    Denisov, O Yu

    1999-01-01

    The testing of 20 models of hard SCSI-disks is carried out: the Fujitsu MAE3091LP; the IBM DDRS-39130, DGHS-318220, DNES-318350, DRHS-36V and DRVS-18V; the Quantum Atlas VI 18.2; the Viking 11 9.1; the Seagate ST118202LW, ST118273LW, ST118273W, ST318203LW, ST318275LW, ST34520W, ST39140LW and ST39173W; and the Western Digital WDE9100-0007, WDE9100-AV0016, WDE9100-AV0030 and WDE9180-0048. All tests ran under the Windows NT 4.0 workstation operating system with Service Pack 4, under video mode with 1024*768 pixel resolution, 32- bit colour depth and V-frequency equal to 85 Hz. The detailed description and characteristics of SCSI stores are presented. Test results (ZD Winstone 99 and ZD WinBench 99 tests) are given in both table and diagram (disk transfer rate) forms. (0 refs).

  13. Myxomatosis in 1950s Britain.

    Science.gov (United States)

    Bartrip, P W J

    2008-01-01

    In 1953 myxomatosis, a viral disease of rabbits, broke out in Britain for the first time. It rapidly killed tens of millions of the animals from Kent to the Shetlands. Many farmers and foresters welcomed a disease that virtually eliminated a longstanding and serious agricultural pest. Others were horrified by the sight of thousands of dead and dying animals. With meat still rationed, consumers rued the loss of a cheap and nutritious foodstuff. Rough shooters deplored the loss of prey and hatters and furriers the unavailability of the fur on which their businesses depended. Rabbits also had champions within the 'establishment'; these included Winston Churchill who was personally influential in making deliberate transmission of the disease a criminal offence. The arrival in Britain of myxomatosis presented the authorities with difficult questions: should they try to contain it, spread it or do nothing; should they take advantage of rabbit depopulation and try to exterminate such a destructive animal? In the event the outbreak was allowed to run its course and rabbit extermination became government policy. This article considers who or what was responsible for the disease reaching the UK and how it then spread throughout the country. It examines the responses of government, other institutions and members of the public. Finally, it explores the impact of rabbit de-population on agriculture, the natural environment and public opinion.

  14. The Prime Minister and the platypus: A paradox goes to war.

    Science.gov (United States)

    Lawrence, Natalie

    2012-03-01

    In February 1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain. This request can only be understood if placed in the context of Churchill's passion for exotic pets as well as the rich history of aristocratic menageries and live diplomatic gifts. Obtaining an animal hitherto unseen alive in Europe would have been a great zoological achievement for London Zoo and secured British authority in heated historical taxonomical debates. This zoological triumph, coupled with accomplishing an extravagant enterprise in the middle of war-time austerity would have boosted public morale. Most importantly, despite its death, the platypus, served as a token for mediating the soured relations between Australia and Britain. Churchill's platypus provides a unique case of animal collecting that incorporates effects on international diplomacy and public relations along with a great private eccentricity and passion. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Role of olmesartan in combination therapy in blood pressure control and vascular function

    Directory of Open Access Journals (Sweden)

    Carlos M Ferrario

    2010-08-01

    Full Text Available Carlos M Ferrario, Ronald D SmithWake Forest University School of Medicine, Winston-Salem, North Carolina, USAAbstract: Angiotensin receptor blockers have emerged as a first-line therapy in the management of hypertension and hypertension-related comorbidities. Since national and international guidelines have stressed the need to control blood pressure to <140/90 mmHg in uncomplicated hypertension and <130/80 mmHg in those with associated comorbidities such as diabetes or chronic kidney disease, these goal blood pressures can only be achieved through combination therapy. Of several drugs that can be effectively combined to attain the recommended blood pressure goals, fixed-dose combinations of angiotensin receptor blockers and the calcium channel blocker amlodipine provide additive antihypertensive effects associated with a safe profile and increased adherence to therapy. In this article, we review the evidence regarding the beneficial effects of renin–angiotensin system blockade with olmesartan medoxomil and amlodipine in terms of blood pressure control and improvement of vascular function and target organ damage.Keywords: amlodipine, angiotensin receptor blockers, angiotensin-converting enzyme 2, hypertension, renin–angiotensin system

  16. Gastroparesis: a review of current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Enweluzo C

    2013-09-01

    Full Text Available Chijioke Enweluzo, Fahad AzizHospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USAAbstract: Gastroparesis is a motility disorder of the stomach causing delay in food emptying from the stomach without any evidence of mechanical obstruction. The majority of cases are idiopathic. Patients need to be diagnosed properly by formal testing, and the evaluation of the severity of the gastroparesis may assist in guiding therapy. Initially, dietary modifications are encouraged, which include frequent and small semisolid-based meals. Promotility medications, like erythromycin, and antiemetics, like prochlorperazine, are offered for symptom relief. In patients who are refractory to pharmacologic treatment, more invasive options, such as intrapyloric botulinum toxin injections, placement of a jejunostomy tube, or implantation of a gastric stimulator, can be considered. Hemin therapy and gastric electric stimulation are emerging treatment options that are still at different stages of research. Regenerative medicine and stem cell-based therapies also hold promise for gastroparesis in the near future.Keywords: Gastroparesis, gastric emptying, gastric electrical stimulation, hemin

  17. Highlights: Spring Council Meeting

    Science.gov (United States)

    Council members present at the May 24, 1981, meeting were Keiiti Aki, Steven Burges (for Jim Wallis), Peter S. Eagleson, E. R. Engdahl, Charles E. Helsley, James R. Heirtzler, Carl Kisslinger, Leslie H. Meredith, Chris N. K. Mooers, Norman F. Ness, Marcia M. Neugebauer, James J. O'Brien, Richard Rapp, Carl Sagan, James C. Savage, Joseph V. Smith, Fred Spilhaus, Donald L. Turcotte, James A. Van Allen, J. Tuzo Wilson, and Jay Winston (for Elmar R. Reiter until his arrival at 6:50 P.M.). David Strangway, representing the Canadian Geophysical Union, and Peter Steinhauser, representing the European Geophysical Society, were special observers at the meeting. Council meetings are open, and a number of section secretaries, committee chairmen, journal editors, and other members attended. The following major actions were adopted by the Council:The experiment of publishing oceanography and lower-atmosphere papers in JGR Green issues alternate to those containing upper-atmosphere papers will be continued through 1982. From preliminary indications the experiment seems to be working, but a full year of data, including a renewal cycle, is needed to assess the success of the experiment. Final decision will be made prior to the 1983 dues notices.

  18. Improving medication adherence of patients with chronic heart failure: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Shah D

    2015-07-01

    Full Text Available Deval Shah,1 Kim Simms,2 Debra J Barksdale,3 Jia-Rong Wu3 1Internal Medicine, Wake Forest Baptist Hospital, Winston-Salem, 2Duke University Hospital, Durham, 3School of Nursing, University of North Carolina, Chapel Hill, NC, USA Abstract: Heart failure is a chronic debilitating illness that affects 5.7 million Americans. The financial burden of heart failure in the US toppled $31 billion in 2012, which is one of the highest among all chronic medical conditions. Medication adherence is a major component of heart failure self-care behaviors. Therefore, medication non-adherence is associated with more emergency department visits, frequent rehospitalizations, and higher medical cost. Medication adherence rates have varied from 10% to 98% depending on the definition and measurement used to assess and analyze adherence. Many factors contribute to medication non-adherence such as lack of support, finances, absent of symptoms, cognitive decline, adverse reactions, depression, poor attention span, poor knowledge about medication, multiple medications, difficulty swallowing large pills, and inconveniences of urinary frequency with diuretics. Researchers have explored various strategies such as the use of pharmacists, nurses, telemedicine, and interdisciplinary teams to provide interventions to improve medication adherence in heart failure. Health care providers should continue to provide education, constantly reinforce the importance of taking medication as prescribed, and when feasible, utilize one of the successful evidence-based strategies to increase adherence. Keywords: pharmacy, tele-health, interdisciplinary, registered nurse, interventions

  19. Self-management in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Pathak SN

    2014-07-01

    Full Text Available Swetha Narahari Pathak,1 Pauline L Scott,1 Cameron West,1 Steven R Feldman,1–3 1Center for Dermatology Research, Departments of Dermatology, 2Center for Dermatology Research, Departments of Pathology, 3Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Psoriasis is a chronic inflammatory disorder effecting the skin and joints. Additionally, multiple comorbidities exist, including cardiovascular, metabolic, and psychiatric. The chronic nature of psoriasis is often frustrating for both patients and physicians alike. Many options for treatment exist, though successful disease management rests largely on patients through the application of topical corticosteroids, Vitamin D analogs, and calcineurin inhibitors, amongst others and the administration of systemic medications such as biologics and methotrexate. Phototherapy is another option that also requires active participation from the patient. Many barriers to effective self-management of psoriasis exist. Successful treatment requires the establishment of a strong doctor-patient relationship and patient empowerment in order to maximize adherence to a treatment regimen and improve outcomes. Improving patient adherence to treatment is necessary in effective self-management. Many tools exist to educate and empower patients, including online sources such as the National Psoriasis Foundation and online support group, Talk Psoriasis, amongst others. Effective self management is critical in decreasing the physical burden of psoriasis and mitigating its multiple physical, psychological, and social comorbidities, which include obesity, cardiovascular disease, alcohol dependence, depression, anxiety, and social anxiety. Keywords: psoriasis, adherence, self management, compliance

  20. Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

    Directory of Open Access Journals (Sweden)

    Ortega VE

    2015-01-01

    Full Text Available Victor E Ortega, Deborah A Meyers, Eugene R Bleecker Center for Genomics and Personalized Medicine Research, Pulmonary Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Human genetics research will be critical to the development of genetic profiles for personalized or precision medicine in asthma. Genetic profiles will consist of gene variants that predict individual disease susceptibility and risk for progression, predict which pharmacologic therapies will result in a maximal therapeutic benefit, and predict whether a therapy will result in an adverse response and should be avoided in a given individual. Pharmacogenetic studies of the glucocorticoid, leukotriene, and β2-adrenergic receptor pathways have focused on candidate genes within these pathways and, in addition to a small number of genome-wide association studies, have identified genetic loci associated with therapeutic responsiveness. This review summarizes these pharmacogenetic discoveries and the future of genetic profiles for personalized medicine in asthma. The benefit of a personalized, tailored approach to health care delivery is needed in the development of expensive biologic drugs directed at a specific biologic pathway. Prior pharmacogenetic discoveries, in combination with additional variants identified in future studies, will form the basis for future genetic profiles for personalized tailored approaches to maximize therapeutic benefit for an individual asthmatic while minimizing the risk for adverse events. Keywords: asthma, pharmacogenetics, response heterogeneity, single nucleotide polymorphism, genome-wide association study

  1. Feedback-driven response to multidecadal climatic variability at an alpine treeline

    Science.gov (United States)

    Alftine, K.J.; Malanson, G.P.; Fagre, D.B.

    2003-01-01

    The Pacific Decadal Oscillation (PDO) has significant climatological and ecological effects in northwestern North America. Its possible effects and their modification by feedbacks are examined in the forest-tundra ecotone in Glacier National Park, Montana, USA. Tree ring samples were collected to estimate establishment dates in 10 quadrats. Age-diameter regressions were used to estimate the ages of uncored trees. The temporal pattern of establishment and survival was compared to the pattern of the PDO. A wave of establishment began in the mid-1940s, rose to a peak rate in the mid-1970s, and dropped precipitously beginning ca. 1980 to near zero for the 1990s. The period of establishment primarily coincided with the negative phase of the PDO, but the establishment and survival pattern is not correlated with the PDO index. The pattern indicates a period during which establishment was possible and was augmented by positive feedback from surviving trees. Snow may be the most important factor in the feedback, but studies indicate that its effects vary locally. Spatially differentiated analyses of decadal or longer periodicity may elucidate responses to climatic variation. ?? 2003 by V. H. Winston and Son, Inc. All rights reserved.

  2. Development of a composite large-size SiPM (assembled matrix) based modular detector cluster for MAGIC

    Science.gov (United States)

    Hahn, A.; Mazin, D.; Bangale, P.; Dettlaff, A.; Fink, D.; Grundner, F.; Haberer, W.; Maier, R.; Mirzoyan, R.; Podkladkin, S.; Teshima, M.; Wetteskind, H.

    2017-02-01

    The MAGIC collaboration operates two 17 m diameter Imaging Atmospheric Cherenkov Telescopes (IACTs) on the Canary Island of La Palma. Each of the two telescopes is currently equipped with a photomultiplier tube (PMT) based imaging camera. Due to the advances in the development of Silicon Photomultipliers (SiPMs), they are becoming a widely used alternative to PMTs in many research fields including gamma-ray astronomy. Within the Otto-Hahn group at the Max Planck Institute for Physics, Munich, we are developing a SiPM based detector module for a possible upgrade of the MAGIC cameras and also for future experiments as, e.g., the Large Size Telescopes (LST) of the Cherenkov Telescope Array (CTA). Because of the small size of individual SiPM sensors (6 mm×6 mm) with respect to the 1-inch diameter PMTs currently used in MAGIC, we use a custom-made matrix of SiPMs to cover the same detection area. We developed an electronic circuit to actively sum up and amplify the SiPM signals. Existing non-imaging hexagonal light concentrators (Winston cones) used in MAGIC have been modified for the angular acceptance of the SiPMs by using C++ based ray tracing simulations. The first prototype based detector module includes seven channels and was installed into the MAGIC camera in May 2015. We present the results of the first prototype and its performance as well as the status of the project and discuss its challenges.

  3. APPLICATION OF IMAGE ANALYSIS METHODS FOR ISOCENTER QUALITY ASSURANCE IN RADIOTHERAPY

    Directory of Open Access Journals (Sweden)

    Michał Niedźwiecki

    2017-03-01

    Full Text Available One of the major procedures for testing the geometrical accuracy of devices used in radiotherapy treatments is the test of the geometrical position of the radiation isocenter. The importance of the test reflects the fact that geometrical position of the radiation isocenter generally affects the tumor targeting. At present the geometric accuracy is assessed with the Winston-Lutz test which checks the position of an image of a ball marker with the respect to the center of the radiation field as projected on a detector plane. Obviously, determination of coordinates of a single marker is not sufficient to fully account for a complicated geometry of a therapeutic device. The purpose of the study was to design a new image analysis tool to better determine the isocenter. The proposed automated procedure for determining isocenter position uses projection data acquired for a special cube phantom. The projection images of a phantom are acquired for various angles of rotation of the gantry. A procedure is proposed to extract some geometric characteristics of a therapeutic device from the projection images.

  4. Computer Security: Thirty years since "1984" - How close was Orwell to today’s interconnected world?

    CERN Multimedia

    Computer Security Team

    2014-01-01

    This year marks the 30th anniversary of the time depicted in the novel 1984, written by the visionary George Orwell in 1947/8, as well as the 25th anniversary of the World Wide Web being invented at CERN. To mark this occasion, both the Cineglobe Film Festival at CERN and the Latitude Festival in the UK are holding panel discussions on the technological and socio-cultural implications of our infinite connectedness in an age of internet surveillance: “How close is our world to that of Orwell's nightmare?”   The novel 1984 describes the fate of its protagonist Winston Smith and his love interest Julia. The setting is “Oceania”, one of three supra-nations at war with one another, a dictatorship blocking all free will (considered to be “thoughtcrime”), altering inconvenient historical truths (using “Newspeak”) and permanently monitoring its citizens (the origin of the phrase “Big Brother is watching ...

  5. Cardiovascular risk prediction: the old has given way to the new but at what risk-benefit ratio?

    Directory of Open Access Journals (Sweden)

    Yeboah J

    2014-10-01

    Full Text Available Joseph Yeboah Heart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: The ultimate goal of cardiovascular risk prediction is to identify individuals in the population to whom the application or administration of current proven lifestyle modifications and medicinal therapies will result in reduction in cardiovascular disease events and minimal adverse effects (net benefit to society. The use of cardiovascular risk prediction tools dates back to 1976 when the Framingham coronary heart disease risk score was published. Since then a lot of novel risk markers have been identified and other cardiovascular risk prediction tools have been developed to either improve or replace the Framingham Risk Score (FRS. In 2013, the new atherosclerotic cardiovascular disease risk estimator was published by the American College of Cardiology and the American Heart Association to replace the FRS for cardiovascular risk prediction. It is too soon to know the performance of the new atherosclerotic cardiovascular disease risk estimator. The risk-benefit ratio for preventive therapy (lifestyle modifications, statin +/− aspirin based on cardiovascular disease risk assessed using the FRS is unknown but it was assumed to be a net benefit. Should we also assume the risk-benefit ratio for the new atherosclerotic cardiovascular disease risk estimator is also a net benefit? Keywords: risk prediction, prevention, cardiovascular disease

  6. THE COMMON HUMANE SHARING IN DIFFERENT MYTHOLOGIES OF THE LORD OF THE RINGS AND 1984

    Directory of Open Access Journals (Sweden)

    Aslı Bülbül CANDAŞ

    2014-05-01

    Full Text Available John Ronald Reuel Tolkien's collection The Silmarillion, which is a utopic creation myth of Middle-earth, Valinor, Numenor and Beleriand, and his novel The Lord of the Rings, which is a saga taking place only in Middle-earth, seem to be completely irrelevant to George Orwell's dystopian world 1984 at first view but when they are examined in detail, two striking common points would be obvious that these myths support the idea of cultural variety's importance and they consist of a war against cultural dominance. In The Lord of the Rings, it is the battle and collaboration of cultures that makes sense in the mythological surrounding of the plot; the creatures come together to defend their cultural history against a single body; Sauron and the Orcs under his rule. As for 1984, the reader is presented with the struggle of a couple, Winston and Julia, to continue their cultural heritage against the dictatorship of Ingsoc which offers the society with an artificial and prototypical culture.

  7. Relying on the National Mobile Disaster Hospital as a business continuity strategy in the aftermath of a tornado: The Louisville experience.

    Science.gov (United States)

    Kearns, Randy D; Stringer, Lew; Craig, James; Godette-Crawford, Regina; Black, Paul S; Andra, David L; Winslow, James

    2017-01-01

    On 28th April, 2014, a tornado left much of Louisville, MS and the local hospital, Winston Medical Center, in ruin. In the USA, temporary hospital solutions have been used to augment the mainstream healthcare system since the American Civil War. As memories fade, however, the necessary readiness for a temporary hospital also fades, at times leaving a patchwork of resources either underfunded or abandoned. With the creation of the Hospital Preparedness Program, several temporary hospital solutions were created in various states across the USA. In the present case, Mississippi and North Carolina resources were used in Louisville in the aftermath of a direct impact that destroyed the hospital and nursing home. In the hours that followed, after lives were saved and patients safely relocated, a frank assessment confirmed the structural loss of the hospital. Local emergency responders, hospital staff, state and federal representatives all rallied with the aim of saving the community's only hospital. The steps taken in Louisville and the deliberate restoration of these essential services offer a learning opportunity for all involved in healthcare disaster preparedness, response and recovery.

  8. "And they told two friends...and so on": RJ Reynolds' viral marketing of Eclipse and its potential to mislead the public.

    Science.gov (United States)

    Anderson, S J; Ling, P M

    2008-08-01

    To explore viral marketing strategies for Eclipse cigarettes used by the RJ Reynolds Company (Winston-Salem, North Carolina, USA). Analysis of previously secret tobacco industry documents and multimedia materials. The failure of RJ Reynolds' (RJR) 1988 "smokeless" cigarette, Premier, was in part due to widespread bad word of mouth about the product's flavour, quality and difficulty of use. In 1994 RJR introduced an updated version of Premier, the ostensibly "reduced risk" Eclipse cigarette. RJR developed viral marketing channels to promote Eclipse using (1) exploratory interviews to motivate consumers to spread the word about Eclipse prior to market release, (2) promotional videos featuring positive feedback from test group participants to portray majority consensus among triers, (3) "Tupperware"-like parties for Eclipse where participants received samples to pass around in their social circles and (4) the Eclipse website's bulletin board as a forum for potential users to discuss the brand in their own words. These strategies targeted the brand's likeliest adopters, recruited informal and credible representatives of the product unaffiliated with RJR, and controlled the information spread about the product. Viral marketing techniques may be particularly useful to promote new tobacco products such as Eclipse that have limited appeal and need a highly motivated audience of early adopters and acceptors. Such techniques help evade the mass rejection that could follow mass promotion, circumvent marketing restrictions, and allow tobacco companies to benefit from health claims made by consumers. Cigarette manufacturers must be held accountable for perceived health benefits encouraged by all promotional activities including viral marketing.

  9. Occulting Light Concentrators in Liquid Scintillator Neutrino Detectors

    Science.gov (United States)

    Buizza Avanzini, Margherita; Cabrera, Anatael; Dusini, Stefano; Grassi, Marco; He, Miao; Wu, Wenjie

    2017-09-01

    The experimental efforts characterizing the era of precision neutrino physics revolve around collecting high-statistics neutrino samples and attaining an excellent energy and position resolution. Next generation liquid-based neutrino detectors, such as JUNO, HyperKamiokande, etc, share the use of a large target mass, and the need of pushing light collection to the edge for maximal calorimetric information. Achieving high light collection implies considerable costs, especially when considering detector masses of several kt. A traditional strategy to maximize the effective photo-coverage with the minimum number of PMTs relies on Light Concentrators (LC), such as Winston Cones. In this paper, the authors introduce a novel concept called Occulting Light Concentrators (OLC), whereby a traditional LC gets tailored to a conventional PMT, by taking into account its single-photoelectron collection efficiency profile and thus occulting the worst performing portion of the photocathode. Thus, the OLC shape optimization takes into account not only the optical interface of the PMT, but also the maximization of the PMT detection performances. The light collection uniformity across the detector is another advantage of the OLC system. By considering the case of JUNO, we will show OLC capabilities in terms of light collection and energy resolution.

  10. Self-Expandable Metal Stent Placement for Closure of a Leak after Total Gastrectomy for Gastric Cancer: Report on Three Cases and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Dario Raimondo

    2014-01-01

    Full Text Available In the setting of the curative oncological surgery, the gastric surgery is exposed to complicated upper gastrointestinal leaks, and consequently the management of this problem has become more critically focused than was previously possible. We report here three cases of placement of a partially silicone-coated SEMS (Evolution Controlled Release Esophageal Stent System, Cook Medical, Winston-Salem, NC, USA in patients who underwent total gastrectomy with Roux-en-Y end-to-side esophagojejunostomy for a gastric adenocarcinoma. The promising results of our report, despite the small number of patients, suggest that early stenting (through a partially silicone-coated SEMS is a feasible alternative to surgical treatment in this subset of patients. In fact, in the treatment of leakage after total gastrectomy, plastic stents and totally covered metallic stents may not adhere sufficiently to the esophagojejunal walls and, as a result, migrate beyond the anastomosis. However, prospective studies with a larger number of patients might assess the real effectiveness and safety of this procedure.

  11. BOLD magnetic resonance imaging in nephrology

    Directory of Open Access Journals (Sweden)

    Hall ME

    2018-03-01

    Full Text Available Michael E Hall,1,2 Jennifer H Jordan,3 Luis A Juncos,1,2 W Gregory Hundley,3 John E Hall2 1Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA; 2Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA; 3Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Magnetic resonance (MR imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important. Blood oxygen level-dependent (BOLD MR is a non-contrast imaging technique that provides functional information related to renal tissue oxygenation in various pathophysiologic conditions. Here we discuss technical considerations, clinical uses and future directions for use of BOLD MR as well as complementary MR techniques to better understand renal pathophysiology. Our intent is to summarize kidney BOLD MR applications for the clinician rather than focusing on the complex physical challenges that functional MR imaging encompasses; however, we briefly discuss some of those issues. Keywords: functional MRI, kidney, oxygenation, chronic kidney disease 

  12. Cigarette smuggling in Europe: who really benefits?

    Science.gov (United States)

    Joossens, L; Raw, M

    1998-01-01

    Cigarette smuggling, now on the increase, is so widespread and well organised that it poses a serious threat to public health. This threat comes from two principal directions. First, smuggling makes cigarettes available cheaply, thereby increasing consumption. A third of annual global exports go to the contraband market, representing an enormous impact on consumption, and thus causing an increase in the burden of disease, especially in poorer countries. It is also costing government treasuries thousands of millions of dollars in lost tax revenue. Second, the tobacco industry uses smuggling politically, lobbying governments to lower tax, arguing that smuggling is caused by price differences. This paper shows that the claimed correlation between high prices and high levels of smuggling does not exist in western Europe. In fact, countries such as Norway and Sweden, with expensive cigarettes, do not have a large smuggling problem, whereas countries in the south of Europe do. Cigarette smuggling is not caused principally by "market forces". It is mainly caused by fraud, by the illegal evasion of import duty. The cigarettes involved are not the cheap brands from southern European countries, for which there is no international market. It is the well-known international brands such as Marlboro and Winston. We propose much tighter regulation of cigarette trade, including an international transport convention, and a total ban on transit trade-sale by the manufacturers to dealers, who sell on to smugglers.

  13. Automatic analysis of image quality control for Image Guided Radiation Therapy (IGRT) devices in external radiotherapy

    International Nuclear Information System (INIS)

    Torfeh, Tarraf

    2009-01-01

    On-board imagers mounted on a radiotherapy treatment machine are very effective devices that improve the geometric accuracy of radiation delivery. However, a precise and regular quality control program is required in order to achieve this objective. Our purpose consisted of developing software tools dedicated to an automatic image quality control of IGRT devices used in external radiotherapy: 2D-MV mode for measuring patient position during the treatment using high energy images, 2D-kV mode (low energy images) and 3D Cone Beam Computed Tomography (CBCT) MV or kV mode, used for patient positioning before treatment. Automated analysis of the Winston and Lutz test was also proposed. This test is used for the evaluation of the mechanical aspects of treatment machines on which additional constraints are carried out due to the on-board imagers additional weights. Finally, a technique of generating digital phantoms in order to assess the performance of the proposed software tools is described. Software tools dedicated to an automatic quality control of IGRT devices allow reducing by a factor of 100 the time spent by the medical physics team to analyze the results of controls while improving their accuracy by using objective and reproducible analysis and offering traceability through generating automatic monitoring reports and statistical studies. (author) [fr

  14. Proposed stratotype for the base of the highest Cambrian stage at the first appearance datum of Cordylodus andresi, Lawson Cove section, Utah, USA

    Science.gov (United States)

    Miller, J.F.; Ethington, Raymond L.; Evans, K.R.; Holmer, L.E.; Loch, James D.; Popov, L.E.; Repetski, J.E.; Ripperdan, R.L.; Taylor, John F.

    2006-01-01

    We propose a candidate for the Global Standard Stratotype-section and Point (GSSP) for the base of the highest stage of the Furongian Series of the Cambrian System. The section is at Lawson Cove in the Ibex area of Millard County, Utah, USA. The marker horizon is the first appearance datum (FAD) of the conodont Cordylodus andresi Viira et Sergeyeva in Kaljo et al. [Kaljo, D., Borovko, N., Heinsalu, H., Khazanovich, K., Mens, K., Popov, L., Sergeyeva, S., Sobolevskaya, R., Viira, V., 1986. The Cambrian-Ordovician boundary in the Baltic-Ladoga clint area (North Estonia and Leningrad Region, USSR). Eesti NSV Teaduste Akadeemia Toimetised. Geologia 35, 97-108]. At this section and elsewhere this horizon also is the FAD of the trilobite Eurekia apopsis (Winston et Nicholls, 1967). This conodont characterizes the base of the Cordylodus proavus Zone, which has been recognized in many parts of the world. This trilobite characterizes the base of the Eurekia apopsis Zone, which has been recognized in many parts of North America. The proposed boundary is 46.7 m above the base of the Lava Dam Member of the Notch Peak Formation at the Lawson Cove section. Brachiopods, sequence stratigraphy, and carbon-isotope geochemistry are other tools that characterize this horizon and allow it to be recognized in other areas. ?? 2006 Nanjing Institute of Geology and Palaeontology, CAS.

  15. A robust Hough transform algorithm for determining the radiation centers of circular and rectangular fields with subpixel accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Du Weiliang; Yang, James [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 94, Houston, TX 77030 (United States)], E-mail: wdu@mdanderson.org

    2009-02-07

    Uncertainty in localizing the radiation field center is among the major components that contribute to the overall positional error and thus must be minimized. In this study, we developed a Hough transform (HT)-based computer algorithm to localize the radiation center of a circular or rectangular field with subpixel accuracy. We found that the HT method detected the centers of the test circular fields with an absolute error of 0.037 {+-} 0.019 pixels. On a typical electronic portal imager with 0.5 mm image resolution, this mean detection error was translated to 0.02 mm, which was much finer than the image resolution. It is worth noting that the subpixel accuracy described here does not include experimental uncertainties such as linac mechanical instability or room laser inaccuracy. The HT method was more accurate and more robust to image noise and artifacts than the traditional center-of-mass method. Application of the HT method in Winston-Lutz tests was demonstrated to measure the ball-radiation center alignment with subpixel accuracy. Finally, the method was applied to quantitative evaluation of the radiation center wobble during collimator rotation.

  16. Measuring the wobble of radiation field centers during gantry rotation and collimator movement on a linear accelerator

    International Nuclear Information System (INIS)

    Du, Weiliang; Gao, Song

    2011-01-01

    Purpose: The isocenter accuracy of a linear accelerator is often assessed with star-shot films. This approach is limited in its ability to quantify three dimensional wobble of radiation field centers (RFCs). The authors report a Winston-Lutz based method to measure the 3D wobble of RFCs during gantry rotation, collimator rotation, and collimator field size change. Methods: A stationary ball-bearing phantom was imaged using multileaf collimator-shaped radiation fields at various gantry angles, collimator angles, and field sizes. The center of the ball-bearing served as a reference point, to which all RFCs were localized using a computer algorithm with subpixel accuracy. Then, the gantry rotation isocenter and the collimator rotation axis were derived from the coordinates of these RFCs. Finally, the deviation or wobble of the individual RFC from the derived isocenter or rotation axis was quantified. Results: The results showed that the RFCs were stable as the field size of the multileaf collimator was varied. The wobble of RFCs depended on the gantry angle and the collimator angle and was reproducible, indicating that the mechanical imperfections of the linac were mostly systematic and quantifiable. It was found that the 3D wobble of RFCs during gantry rotation was reduced after compensating for a constant misalignment of the multileaf collimator. Conclusions: The 3D wobble of RFCs can be measured with submillimeter precision using the proposed method. This method provides a useful tool for checking and adjusting the radiation isocenter tightness of a linac.

  17. Measuring the wobble of radiation field centers during gantry rotation and collimator movement on a linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Du, Weiliang; Gao, Song [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, 77030 (United States)

    2011-08-15

    Purpose: The isocenter accuracy of a linear accelerator is often assessed with star-shot films. This approach is limited in its ability to quantify three dimensional wobble of radiation field centers (RFCs). The authors report a Winston-Lutz based method to measure the 3D wobble of RFCs during gantry rotation, collimator rotation, and collimator field size change. Methods: A stationary ball-bearing phantom was imaged using multileaf collimator-shaped radiation fields at various gantry angles, collimator angles, and field sizes. The center of the ball-bearing served as a reference point, to which all RFCs were localized using a computer algorithm with subpixel accuracy. Then, the gantry rotation isocenter and the collimator rotation axis were derived from the coordinates of these RFCs. Finally, the deviation or wobble of the individual RFC from the derived isocenter or rotation axis was quantified. Results: The results showed that the RFCs were stable as the field size of the multileaf collimator was varied. The wobble of RFCs depended on the gantry angle and the collimator angle and was reproducible, indicating that the mechanical imperfections of the linac were mostly systematic and quantifiable. It was found that the 3D wobble of RFCs during gantry rotation was reduced after compensating for a constant misalignment of the multileaf collimator. Conclusions: The 3D wobble of RFCs can be measured with submillimeter precision using the proposed method. This method provides a useful tool for checking and adjusting the radiation isocenter tightness of a linac.

  18. Preoperative psychological assessment of patients seeking weight-loss surgery: identifying challenges and solutions

    Directory of Open Access Journals (Sweden)

    Edwards-Hampton SA

    2015-11-01

    Full Text Available Shenelle A Edwards-Hampton,1 Sharlene Wedin2 1Department of General Surgery, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC, 2Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA Abstract: Preoperative psychosocial assessment is the standard of care for patients seeking weight-loss surgery (WLS. However, the assessment procedure varies widely by surgery site. Comprehensive assessments can provide a wealth of information that assists both the patient and the treatment team, anticipate and prepare for challenges associated with extensive behavioral and lifestyle changes that are required postsurgery. In this review, we provide an overview of the purpose of the preoperative psychosocial assessment and domains to be included. Challenges commonly identified in the assessment are discussed, including maladaptive eating behaviors, psychiatric comorbidities, and alcohol use. Potential solutions and approaches to these challenges are provided. Additionally, patient populations requiring special consideration are presented to include adolescents, those with cognitive vulnerabilities, and aging adults. Keywords: bariatric surgery, preoperative assessment, weight-loss surgery, challenges, adolescents, older adults, cognitive impairment, maladaptive eating, alcohol misuse

  19. New developments in the treatment of rosacea – role of once-daily ivermectin cream

    Directory of Open Access Journals (Sweden)

    Cardwell LA

    2016-03-01

    Full Text Available Leah A Cardwell,1 Hossein Alinia,1 Sara Moradi Tuchayi,1 Steven R Feldman,1–31Department of Dermatology, Center for Dermatology Research, 2Department of Pathology, 3Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include immune abnormality, vascular abnormality, neurogenic dysregulation, presence of cutaneous microorganisms, UV damage, and skin barrier dysfunction. The role of ivermectin in the treatment of rosacea may be as an anti-inflammatory and anti-parasitic agent targeting Demodex mites. In comparing topical ivermectin and metronidazole, ivermectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Patients who received ivermectin 1% cream had an acceptable safety profile. Ivermectin is efficacious in decreasing inflammatory lesion counts and erythema. Keywords: papulopustular rosacea, topical ivermectin, metronidazole, azelaic acid, topical

  20. A Critical Study of Selected Political Elites' Discourse in English

    Directory of Open Access Journals (Sweden)

    Biook Behnam

    2008-02-01

    Full Text Available This study explored how political elites can contribute to power enactment through using language. It started with a theoretical overview of Critical Discourse Analysis (CDA, and then presented a corpus consisting of speeches of eight political elites, namely, Malcolm X, Noam Chomsky, Martin Luther King, Josef Stalin, Vladimir Lenin, Winston Churchill, J.F. Kennedy and Adolph Hitler. This study analyzed speeches in terms of figures of' speech, and interpreted them from the point of view of CDA using the framework introduced by Fairclough (1989 as a three-dimensional approach to the study of discourse (Description, Interpretation, Explanation and van Dijk (2004 as the theory of critical context analysis.. Speech figures are classified in this study into six main categories as Comparison, Grammar, Meaning, Parenthesis, Repetition and Rhetoric. The result of analyses reveals that while there are differences in the type and degree of speech figures employed by our selected individual political elites, there is one striking pattern which is common among all speeches: the frequent use of figures of Grammar, Repetition and Rhetoric

  1. Evaluation of a Cultural Competence Intervention with Implications for the Nurse-Patient Encounter

    Science.gov (United States)

    Bradford, Althea Betty

    A short-term intervention on participants' knowledge of cultural competence was provided to 38 students in a baccalaureate nursing program at Winston-Salem State University (WSSU). The study examined the effectiveness of this intervention. Although WSSU is a Historically Black University, the majority of students in this program were White. Six tools were used for data collection. The Cultural Competence Survey consisted of 19 Likert Scale items that also gave participants an opportunity to elaborate on each response. Four tools allowed participants to provide written answers to prompts related to cultural competence. The final tool made it possible for the investigator to record impressions and reflections regarding various aspects of the study. Results showed that the students are familiar with cultural competence and want to avoid stereotypical behavior in their nurse-patient encounters. The study suggests a need for education in cultural competence in three areas: 1) accepting that cultural competence is a lifelong endeavor, 2) understanding patients from a holistic perspective, and 3) recognizing that all people have biases; however, the competent nurse is self-aware and has been educated to recognize biased behavior.

  2. "WE ARE ALL IN THE SAME BOAT NOW" PROVERBIAL RHETORIC IN THE CHURCHILL-ROOSEVELT CORRESPONDENCE

    Directory of Open Access Journals (Sweden)

    Wolfgang Mieder

    2006-06-01

    Full Text Available Both Winston S. Churchill (1874-1965 and Franklin D. Roosevelt (1 882-1945 were masters of the English language and effective orators, rallying their people through word and deed to fight as allies against the dictatorial powers during the Second World War. Their public speeches and interviews are replete with proverbs, proverbial expressions, and other phraseologisms. This is also true for their private and secretive letters, messages, memoranda, and telegrams, as can be seen from the materials that Warren F. Kimball edited in the three volumes of Churchill & Roosevelt: The Complete Correspondence (Princeton, NJ: Princeton University Press, 1984. The proverbial language, especially metaphorical texts referring to the body, animals, and the military, gives their important communications a lively and humane flavor that illustrates their deep friendship, trust, and support of each other. Frequently used as metaphorical arguments, these proverbial interjections into an otherwise factual epistolary exchange from 1933 to 1945 bear witness to the determination of these two world leaders to win the struggle for a free world.

  3. Meaningful learning: The essential factor for conceptual change in limited or inappropriate propositional hierarchies leading to empowerment of learners

    Science.gov (United States)

    Novak, Joseph D.

    2002-07-01

    The construction and reconstruction of meanings by learners requires that they actively seek to integrate new knowledge with knowledge already in their cognitive structure. Ausubel's assimilation theory of cognitive learning has been shown to be effective in guiding research and instructional design to facilitate meaningful learning (Ausubel, The psychology of meaningful verbal learning, New York: Grune and Stratton, 1963; Educational psychology: A cognitive view, New York: Holt, Rinehart and Winston, 1968; The acquisition and retention of knowledge, Dordrecht: Kluwer, 2000). Gowin's Vee heuristic has been employed effectively to aid teachers and students in understanding the constructed nature of knowledge (Gowin, Educating, Ithaca, NY: Cornell University Press, 1981). Situated learning occurs when learning is by rote or at a lower level of meaningful learning. Concept mapping has been used effectively to aid meaningful learning with resulting modification of student's knowledge structures. When these knowledge structures are limited or faulty in some way, they may be referred to as Limited or Inappropriate Propositional Hierarchies (LIPH's). Conceptual change, or more accurately conceptual reconstrution, requires meaningful learning to modify LIPH's. Collaborative group learning facilitates meaningful learning and new knowledge construction. World-wide economic changes are forcing major changes in business and industry placing a premium on the power and value of knowledge and new knowledge production. These changes require changes in school and university education that centers on the nature and power of meaningful learning. New computer tools are available to facilitate teaching activities targeted at modifying LIPH's, and aiding meaningful learning in general.

  4. Focal plane optics in far-infrared and submillimeter astronomy

    Science.gov (United States)

    Hildebrand, R. H.

    1985-01-01

    The construction of airborne observatories, high mountain-top observatories, and space observatories designed especially for infrared and submillimeter astronomy has opened fields of research requiring new optical techniques. A typical far-IR photometric study involves measurement of a continuum spectrum in several passbands between approx 30 microns and 1000 microns and diffraction-limited mapping of the source. At these wavelengths, diffraction effects strongly influence the design of the field optics systems which couple the incoming flux to the radiation sensors (cold bolometers). The Airy diffraction disk for a typical telescope at submillimeter wavelengths approx 100 microns-1000 microns is many millimeters in diameter; the size of the field stop must be comparable. The dilute radiation at the stop is fed through a Winston nonimaging concentrator to a small cavity containing the bolometer. The purpose of this paper is to review the principles and techniques of infrared field optics systems, including spectral filters, concentrators, cavities, and bolometers (as optical elements), with emphasis on photometric systems for wavelengths longer than 60 microns.

  5. Retrospective on 30 years of nonimaging optics development for solar energy at the University of Chicago

    Science.gov (United States)

    O'Gallagher, Joseph J.

    2016-09-01

    As the field of nonimaging optics has developed over the last 50 years, among its many applications, the best known and recognized is probably in solar energy. In particular, the approach provides the formalism that allows the design of devices that approach the maximum physically attainable geometric concentration for a given set of optical tolerances. This means that it has the potential to revolutionize the design of solar concentrators. Much of the experimental development and early testing of these concepts was carried out at the University of Chicago by Roland Winston and his colleagues and students. In this presentation, some of many embodiments and variations of the basic Compound Parabolic Concentrator that were developed and tested over a thirty-year period at Chicago are reviewed. Practical and economic aspects of concentrator design for both thermal and photovoltaic applications are discussed. Examples covering the whole range of concentrator applications from simple low-concentration non-tracking designs to ultrahigh-concentration multistage configurations are covered.

  6. Focal plane optics in far-infrared and submillimeter astronomy

    Science.gov (United States)

    Hildebrand, R. H.

    1986-02-01

    The construction of airborne observatories, high mountain-top observatories, and space observatories designed especially for infrared and submillimeter astronomy has opened fields of research requiring new optical techniques. A typical far-IR photometric study involves measurement of a continuum spectrum in several passbands between approx 30 microns and 1000 microns and diffraction-limited mapping of the source. At these wavelengths, diffraction effects strongly influence the design of the field optics systems which couple the incoming flux to the radiation sensors (cold bolometers). The Airy diffraction disk for a typical telescope at submillimeter wavelengths approx 100 microns-1000 microns is many millimeters in diameter; the size of the field stop must be comparable. The dilute radiation at the stop is fed through a Winston nonimaging concentrator to a small cavity containing the bolometer. The purpose of this paper is to review the principles and techniques of infrared field optics systems, including spectral filters, concentrators, cavities, and bolometers (as optical elements), with emphasis on photometric systems for wavelengths longer than 60 microns.

  7. Promoting physical activity for elders with compromised function: the Lifestyle Interventions and Independence for Elders (LIFE Study physical activity intervention

    Directory of Open Access Journals (Sweden)

    Rejeski WJ

    2013-09-01

    Full Text Available W Jack Rejeski,1 Robert Axtell,2 Roger Fielding,3 Jeffrey Katula,1 Abby C King,4 Todd M Manini,5 Anthony P Marsh,1 Marco Pahor,5 Alvito Rego,6 Catrine Tudor-Locke,7 Mark Newman,8 Michael P Walkup,9 Michael E Miller9  On behalf of the LIFE Study Investigator Group 1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, 2Exercise Science Department, Southern Connecticut State University, New Haven, CT, 3Nutrtion, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 4Department of Health Research and Policy and Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, 5Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, 6Department of Internal Medicine, Northwestern School of Medicine, Chicago, IL, 7Pennington Biomedical Research Center, Baton Rouge, LA, 8Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 9Department of Biostatistical Sciences, Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA Abstract: The Lifestyle Interventions and Independence for Elders (LIFE Study is a Phase III randomized controlled clinical trial (Clinicaltrials.gov identifier: NCT01072500 that will provide definitive evidence regarding the effect of physical activity (PA on major mobility disability in older adults (70–89 years old who have compromised physical function. This paper describes the methods employed in the delivery of the LIFE Study PA intervention, providing insight into how we promoted adherence and monitored the fidelity of treatment. Data are presented on participants' motives and self-perceptions at the onset of the trial along with accelerometry data on patterns of PA during exercise training. Prior to the onset of training, 31.4% of

  8. Assessing balance through the use of a low-cost head-mounted display in older adults: a pilot study

    Directory of Open Access Journals (Sweden)

    Saldana SJ

    2017-08-01

    Full Text Available Santiago J Saldana,1 Anthony P Marsh,2 W Jack Rejeski,2 Jack K Haberl,2 Peggy Wu,3 Scott Rosenthal,4 Edward H Ip1 1Department of Biostatistical Sciences, Wake Forest School of Medicine, 2Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, 3Research and Development, Smart Information Flow Technologies, Minneapolis, MN, 4Wake Forest School of Medicine, Winston-Salem, NC, USA Introduction: As the population ages, the prevention of falls is an increasingly important public health problem. Balance assessment forms an important component of fall-prevention programs for older adults. The recent development of cost-effective and highly responsive virtual reality (VR systems means new methods of balance assessment are feasible in a clinical setting. This proof-of-concept study made use of the submillimeter tracking built into modern VR head-mounted displays (VRHMDs to assess balance through the use of visual–vestibular conflict. The objective of this study was to evaluate the validity, acceptability, and reliability of using a VRHMD to assess balance in older adults.Materials and methods: Validity was assessed by comparing measurements from the VRHMD to measurements of postural sway from a force plate. Acceptability was assessed through the use of the Simulator Sickness Questionnaire pre- and postexposure to assess possible side effects of the visual–vestibular conflict. Reliability was assessed by measuring correlations between repeated measurements 1 week apart. Variables of possible importance that were found to be reliable (r≥0.9 between tests separated by a week were then tested for differences compared to a control group. Assessment was performed as a cross-sectional single-site community center-based study in 13 older adults (≥65 years old, 80.2±7.3 years old, 77% female, five at risk of falls, eight controls. The VR balance assessment consisted of four modules: a baseline module, a reaction module, a

  9. The most important single factor influencing learning is what the learner already knows - What do the learner know about clouds, precipitation, wind and greenhouse effect; a short review of research from 1883 to 2009

    Science.gov (United States)

    Hansen, P. J. K.

    2009-09-01

    If I had to reduce all of educational psychology to just one principle, I would say this: The most important single factor influencing learning is what the learner already knows. Ascertain this and teach him accordingly. This famous quotation from David Ausubel in 1968 points out one of the fundaments for constructivism as theory of learning and knowledge, and states a still common held teaching approach. The first one found to investigate "what the learner already knows" about weather and climate elements, was the American pioneer psychologist Granville Stanley Hall in 1883, studying children of age 4 to 8. Since then many articles and books have been written on the same topics under different theories of learning, knowledge and teaching. Most outstanding are two books from Jean Piaget in 1926 and 1927, both including children's shifting ideas from age 3 to 12 about weather and climate elements and their causes. His books were the start of his lifelong work (till 1980) on what he called theory of Genetic Epistemology, another fundament of constructivism. Common features of Hall, Piaget and many other researches' discoveries are for instance that the youngest children (book chapters - often together with researchers from other countries. Common features of Hansen, Boyes and Stanisstreet and many other researchers' discoveries up to present, are that students on all levels still exchange or confuse the greenhouse effect with the effects of the ozone layer, and many thinks that the greenhouse effect is not necessary for life on the Erath. The greenhouse effect and related topics came into secondary curriculum during the 1990-ies in many countries. The presentation will discuss some ideas of how to teach him accordingly at secondary education. Ausubel, D. P. 1968: Educational Psychology: A Cognitive View. Holt, Rinehart and Winston Inc. New York. Ausubel, D. P., J. D. Novak og H. Hanesian 1978: Educational Psychology. A Cognitive View. Second Edition. Holt, Rinehart

  10. What Followers Want from Their Leaders: An Analytical Perspectivas Lo que los seguidores esperan de sus líderes: Una perspectiva analítica

    Directory of Open Access Journals (Sweden)

    Rodrigo Zárate Torres

    2009-12-01

    Full Text Available Many researchers and others interested in the field of leadership have written about the characteristics and styles of leadership; however, few have written about what followers want from their leaders. This paper addresses the issue of what followers desire in those they follow, it will assert that the basic characteristics followers want from their leaders are Honesty, Forward-Looking, Inspiring, and Competency. Also, followers want to trust in their leaders and they want leaders who care about them, which is shown in the leaders seeing the followers as partners. This paper also compares what international studies found about this leader-follower dynamic with a study made by Colegio de Estudios Superiores de Administracion - CESA where leaders were asked about the main characteristics of an organizational leader. The analysis shows that followers want to commit to their leaders. They want to know that there is a relationship between them. As mentioned by Winston (2002, the relationship between leader and follower has to have the same commitment that exists between husband and wife. In addition, this paper presents the conceptual framework of the analysis and the leadership models that fit more with what followers want from their leaders which are Transformational and Charismatic leadership.Muchos investigadores y otros interesados en el campo del liderazgo han escrito acerca de las características y estilos de liderazgo; no obstante, pocos han tratado sobre aquello que los seguidores quieren de sus líderes. El presente artículo aborda esta cuestión y afirma que las características básicas que los seguidores quieren de sus líderes son: Honestidad, visión progresista, inspiración y competencia. Además, los seguidores quieren confiar en sus líderes y que estos se preocupen de ellos, aspecto que se evidencia cuando los líderes ven a sus seguidores como socios. El documento también compara los resultados de estudios internacionales

  11. Poster — Thur Eve — 55: An automated XML technique for isocentre verification on the Varian TrueBeam

    International Nuclear Information System (INIS)

    Asiev, Krum; Mullins, Joel; DeBlois, François; Liang, Liheng; Syme, Alasdair

    2014-01-01

    Isocentre verification tests, such as the Winston-Lutz (WL) test, have gained popularity in the recent years as techniques such as stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments are more commonly performed on radiotherapy linacs. These highly conformal treatments require frequent monitoring of the geometrical accuracy of the isocentre to ensure proper radiation delivery. At our clinic, the WL test is performed by acquiring with the EPID a collection of 8 images of a WL phantom fixed on the couch for various couch/gantry angles. This set of images is later analyzed to determine the isocentre size. The current work addresses the acquisition process. A manual WL test acquisition performed by and experienced physicist takes in average 25 minutes and is prone to user manipulation errors. We have automated this acquisition on a Varian TrueBeam STx linac (Varian, Palo Alto, USA). The Varian developer mode allows the execution of custom-made XML script files to control all aspects of the linac operation. We have created an XML-WL script that cycles through each couch/gantry combinations taking an EPID image at each position. This automated acquisition is done in less than 4 minutes. The reproducibility of the method was verified by repeating the execution of the XML file 5 times. The analysis of the images showed variation of the isocenter size less than 0.1 mm along the X, Y and Z axes and compares favorably to a manual acquisition for which we typically observe variations up to 0.5 mm

  12. SU-F-J-53: A 3D Printed Phantom for the Use of Daily Quality Assurance Alignment Tests

    Energy Technology Data Exchange (ETDEWEB)

    Woods, K; Ayan, A; Woollard, J; Gardner, N; Gupta, N [Ohio State University Columbus, OH (United States)

    2016-06-15

    Purpose: To discuss experiences and results for a 3D printed QA phantom used for daily alignment purposes for a six degrees-of-freedom (6DoF) table Methods: A 3D model was created using a fused deposition modeling (FDM) printer using free online computer-aided design (CAD) software. The model has been under use for daily QA alignment tests for a 6DoF couch. An aligned and angled baseplate were also printed in order to introduce known angles for 6DoF corrections during image-guidance. Unique registration contours were created on the faces of the phantom in order to achieve a better cone-beam computed tomography (CBCT) match using an auto-registration algorithm. A BB was also introduced at the center of the phantom in order to deliver an integrated daily Winston-Lutz (WL) test. Translational, rotational, and WL results were tabulated over one month. Results: The ’honeycomb’ structure of the print was apparent in the EPID images for the WL test, which affected the results of the analysis software. This was fixed by inserting a cube made of polyoxymethylene within the 3D phantom that encompass the BB. Auto-registration results for the three translational and three rotational from a known offset to the BB isocenter consistently fell within 1 mm and 0.2°, respectively. WL tests resulted in an average of 0.71 ± 0.14 mm. Conclusion: 3D printed models allow for accurate builds that can be customized to a variety of clinical needs. Results from translational, rotational, and WL show consistent results over a month’s time. Given its relatively cheap and streamlined workflow, 3D printing could be implemented into any clinic looking to create customized phantoms.

  13. SU-F-J-53: A 3D Printed Phantom for the Use of Daily Quality Assurance Alignment Tests

    International Nuclear Information System (INIS)

    Woods, K; Ayan, A; Woollard, J; Gardner, N; Gupta, N

    2016-01-01

    Purpose: To discuss experiences and results for a 3D printed QA phantom used for daily alignment purposes for a six degrees-of-freedom (6DoF) table Methods: A 3D model was created using a fused deposition modeling (FDM) printer using free online computer-aided design (CAD) software. The model has been under use for daily QA alignment tests for a 6DoF couch. An aligned and angled baseplate were also printed in order to introduce known angles for 6DoF corrections during image-guidance. Unique registration contours were created on the faces of the phantom in order to achieve a better cone-beam computed tomography (CBCT) match using an auto-registration algorithm. A BB was also introduced at the center of the phantom in order to deliver an integrated daily Winston-Lutz (WL) test. Translational, rotational, and WL results were tabulated over one month. Results: The ’honeycomb’ structure of the print was apparent in the EPID images for the WL test, which affected the results of the analysis software. This was fixed by inserting a cube made of polyoxymethylene within the 3D phantom that encompass the BB. Auto-registration results for the three translational and three rotational from a known offset to the BB isocenter consistently fell within 1 mm and 0.2°, respectively. WL tests resulted in an average of 0.71 ± 0.14 mm. Conclusion: 3D printed models allow for accurate builds that can be customized to a variety of clinical needs. Results from translational, rotational, and WL show consistent results over a month’s time. Given its relatively cheap and streamlined workflow, 3D printing could be implemented into any clinic looking to create customized phantoms.

  14. The coefficient of friction of chrysotile gouge at seismogenic depths

    Science.gov (United States)

    Moore, Diane E.; Lockner, D.A.; Tanaka, H.; Iwata, K.

    2004-01-01

    We report new strength data for the serpentine mineral chrysotile at effective normal stresses, ??sn between 40 and 200 MPa in the temperature range 25??-280??C. Overall, the coefficient of friction, ?? (= shear stress/effective normal stress) of water-saturated chrysotile gouge increases both with increasing temperature and ??sn, but the rates vary and the temperature-related increases begin at ???100??C. As a result, a frictional strength minimum (?? = 0.1) occurs at low ??sn at about 100??C. Maximum strength (?? = 0.55) results from a combination of high normal stress and high temperature. The low-strength region is characterized by velocity strengthening and the high-strength region by velocity-weakening behavior. Thoroughly dried chrysotile has ?? = 0.7 and is velocity-weakening. The frictional properties of chrysolite can be explained in its tendency to adsorb large amounts of water that acts as a lubricant during shear. The water is progressively driven off the fiber surfaces with increasing temperature and pressure, causing chrysotile to approach its dry strength. Depth profiles for a chrysotile-lined fault constructed from these data would pass through a strength minimum at ???3 km depth, where sliding should be stable. Below that depth, strength increases rapidly as does the tendency for unstable (seismic) slip. Such a trend would not have been predicted from the room-temperature data. These results therefore illustrate the potential hazards of extrapolating room-temperature friction data to predict fault zone behavior at depth. This depth profile for chrysotile is consistent with the pattern of slip on the Hayward fault, which creeps aseismically at shallow depths but which may be locked below 5 km depth. ?? 2004 by V. H. Winston and Son, Inc. All rights reserved.

  15. The first 8 years: International Medical Case Reports Journal – summary of publications from 2008 to July 2016

    Directory of Open Access Journals (Sweden)

    Prineas RJ

    2017-03-01

    Full Text Available RJ Prineas,1 SG Fraser,2 CE Stevens31Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 2Sunderland Eye Infirmary, Sunderland, UK; 3Department of Epidemiology, New York Blood Center, New York, NY, USAThe case report has a secure place in medical reporting and medical history stretching back to hand-written manuscripts, early medical texts, and earliest medical scientific publications. As scientific methods took hold, fewer case histories were accepted for publication, being replaced by case series and then analyses from epidemiologic studies, clinical trials (controlled and otherwise, and reports of laboratory clinical practice. Clinicopathology conferences around reporting and presentation of separate cases continue to be convened for regular meetings in hospitals and medical schools for teaching purposes. Case reports appear regularly in sections of medical journals or, more recently, as separate journals devoted entirely to them. Further, open-access case report journals have increased in number markedly in the past decade in parallel with International Medical Case Reports Journal (IMCRJ submissions.1Since the beginning of the publication, the number of journal articles published in IMCRJ has increased steadily from 3 in the inauguration year (2008 to 69 in the latest full year of publication (Table 1, indicating the growing interest in disseminating such reports.The Journal, established by Dove Press, started publishing in 2008. During the first 8 years (until July 2016, published reports came from 50 separate countries (including articles from Africa, Asia, Europe UK, and USA. Sixty one percent of submitted reports (235/387 have been published, and 152 reports were rejected.The number of “reviewers” for each report ranged from 2 to 6, with an average of 3. The 3 leading countries submitting articles were the United States, Japan, and Turkey. Most papers have come from a single author

  16. Evaluating the acute effects of oral, non-combustible potential reduced exposure products marketed to smokers.

    Science.gov (United States)

    Cobb, C O; Weaver, M F; Eissenberg, T

    2010-10-01

    Non-combustible potential reduced exposure products (PREPs; eg, Star Scientific's Ariva; a variety of other smokeless tobacco products) are marketed to reduce the harm associated with smoking. This marketing occurs despite an absence of objective data concerning the toxicant exposure and effects of these PREPs. Methods used to examine combustible PREPs were adapted to assess the acute effects of non-combustible PREPs for smokers. 28 overnight abstinent cigarette smokers (17 men, 14 non-white) each completed seven, Latin-squared ordered, approximately 2.5 h laboratory sessions that differed by product administered: Ariva, Marlboro Snus (Philip Morris, USA), Camel Snus (RJ Reynolds, Winston-Salem, North Carolina, USA), Commit nicotine lozenge (GlaxoSmithKline; 2 mg), own brand cigarettes, Quest cigarettes (Vector Tobacco; delivers very low levels of nicotine) and sham smoking (ie, puffing on an unlit cigarette). In each session, the product was administered twice (separated by 60 min), and plasma nicotine levels, expired air CO and subjective effects were assessed regularly. Non-combustible products delivered less nicotine than own brand cigarettes, did not expose smokers to CO and failed to suppress tobacco abstinence symptoms as effectively as combustible products. While decreased toxicant exposure is a potential indicator of harm reduction potential, a failure to suppress abstinence symptoms suggests that currently marketed non-combustible PREPs may not be a viable harm reduction strategy for US smokers. This study demonstrates how clinical laboratory methods can be used to evaluate the short-term effects of non-combustible PREPs for smokers.

  17. Optical Coating Performance for Heat Reflectors of the JWST-ISIM Electronic Component

    Science.gov (United States)

    Rashford, Robert A.; Perrygo, Charles M.; Garrison, Matthew B.; White, Bryant K.; Threat, Felix T.; Quijada, Manuel A.; Jeans, James W.; Huber, Frank K.; Bousquet, Robert R.; Shaw, Dave

    2011-01-01

    A document discusses a thermal radiator design consisting of lightweight composite materials and low-emittance metal coatings for use on the James Webb Space Telescope (JWST) structure. The structure will have a Thermal Subsystem unit to provide passive cooling to the Integrated Science Instrument Module (ISIM) control electronics. The ISIM, in the JWST observatory, is the platform that provides the mounting surfaces for the instrument control electronics. Dissipating the control electronic generated-heat away from JWST is of paramount importance so that the spacecraft s own heat does not interfere with the infrared-light gathering of distant cosmic sources. The need to have lateral control in the emission direction of the IEC (ISIM Electronics Compartment) radiators led to the development of a directional baffle design that uses multiple curved mirrorlike surfaces. This concept started out from the so-called Winston non-imaging optical concentrators that use opposing parabolic reflector surfaces, where each parabola has its focus at the opposite edge of the exit aperture. For this reason they are often known as compound parabolic concentrators or CPCs. This radiator system with the circular section was chosen for the IEC reflectors because it offers two advantages over other designs. The first is that the area of the reflector strips for a given radiator area is less, which results in a lower mass baffle assembly. Secondly, the fraction of energy emitted by the radiator strips and subsequently reflected by the baffle is less. These fewer reflections reduced the amount of energy that is absorbed and eventually re-emitted, typically in a direction outside the design emission range angle. A baffle frame holds the mirrors in position above a radiator panel on the IEC. Together, these will direct the majority of the heat from the IEC above the sunshield away towards empty space.

  18. Development of a composite large-size SiPM (assembled matrix) based modular detector cluster for MAGIC

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, A., E-mail: ahahn@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Mazin, D., E-mail: mazin@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa City, Chiba 277–8582 (Japan); Bangale, P., E-mail: priya@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Dettlaff, A., E-mail: todettl@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Fink, D., E-mail: fink@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Grundner, F., E-mail: grundner@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Haberer, W., E-mail: haberer@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Maier, R., E-mail: rma@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); and others

    2017-02-11

    The MAGIC collaboration operates two 17 m diameter Imaging Atmospheric Cherenkov Telescopes (IACTs) on the Canary Island of La Palma. Each of the two telescopes is currently equipped with a photomultiplier tube (PMT) based imaging camera. Due to the advances in the development of Silicon Photomultipliers (SiPMs), they are becoming a widely used alternative to PMTs in many research fields including gamma-ray astronomy. Within the Otto-Hahn group at the Max Planck Institute for Physics, Munich, we are developing a SiPM based detector module for a possible upgrade of the MAGIC cameras and also for future experiments as, e.g., the Large Size Telescopes (LST) of the Cherenkov Telescope Array (CTA). Because of the small size of individual SiPM sensors (6 mm×6 mm) with respect to the 1-inch diameter PMTs currently used in MAGIC, we use a custom-made matrix of SiPMs to cover the same detection area. We developed an electronic circuit to actively sum up and amplify the SiPM signals. Existing non-imaging hexagonal light concentrators (Winston cones) used in MAGIC have been modified for the angular acceptance of the SiPMs by using C++ based ray tracing simulations. The first prototype based detector module includes seven channels and was installed into the MAGIC camera in May 2015. We present the results of the first prototype and its performance as well as the status of the project and discuss its challenges. - Highlights: • The design of the first SiPM large-size IACT pixel is described. • The simulation of the light concentrators is presented. • The temperature stability of the detector module is demonstrated. • The calibration procedure of SiPM device in the field is described.

  19. Update on options for treatment of metastatic castration-resistant prostate cancer

    Directory of Open Access Journals (Sweden)

    Prakash Vishnu

    2010-03-01

    Full Text Available Prakash Vishnu, Winston W TanDivision of Hematology Oncology, Mayo Clinic, Jacksonville, FL, USABackground: Prostate cancer is one of the most common cancers in men in US and European countries. Despite having a favorable prognosis, the incidence of incurable metastatic disease and mortality in the US is about 28,000 per year. Although hormone-based androgen deprivation therapies typically result in rapid responses, nearly all patients eventually develop progressive castration-resistant disease state. With readily available prostate-specific antigen (PSA testing, most of these patients are asymptomatic and manifest progression simply as a rising PSA. In patients with castration-resistant prostate cancer (CRPC, the median survival is about 1–2 years, with improvements in survival seen mostly with docetaxel-based regimens. The purpose of this article is to review the recent developments in the treatment of advanced CRPC.Recent findings: Since the two landmark trials (TAX-327 and Southwest Oncology Group 99–16 in CRPC, several newer cytotoxic drugs (epothilones, satraplatin, targeted agents (abiraterone, MDV3100 and vaccines have been tested in phase II and III setting with promising results.Conclusions: The role of newer agents in the treatment of CRPC still needs to be validated by phase III trials, which are currently ongoing. Whilst the novel biomarkers, ‘circulating tumor cells’, have been shown to provide important prognostic information and are anticipated to be incorporated in future clinical decision-making, their exact utility and relevance calls for a larger prospective validation.Keywords: castration-resistant prostate cancer, novel therapies, mechanisms of resistance, circulating tumor cells

  20. Poster — Thur Eve — 32: Stereotactic Body Radiation Therapy for Peripheral Lung Lesion: Treatment Planning and Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Shuying; Oliver, Michael; Wang, Xiaofang [Northeast Cancer Centre, Health Sciences North, Sudbury, Ontario (Canada)

    2014-08-15

    Stereotactic body radiation therapy (SBRT), due to its high precision for target localizing, has become widely used to treat tumours at various locations, including the lungs. Lung SBRT program was started at our institution a year ago. Eighteen patients with peripheral lesions up to 3 cm diameter have been treated with 48 Gy in 4 fractions. Based on four-dimensional computed tomography (4DCT) simulation, internal target volume (ITV) was delineated to encompass the respiratory motion of the lesion. A margin of 5 mm was then added to create the planning target volume (PTV) for setup uncertainties. There was no expansion from gross tumour volume (GTV) to clinical target volume (CTV). Pinnacle 9.6 was used as the primary treatment planning system. Volumetric modulated arc therapy (VMAT) technique, with one or two coplanar arcs, generally worked well. For quality assurance (QA), each plan was exported to Eclipse 10 and dose calculation was repeated. Dose volume histograms (DVHs) of the targets and organs at risk (OARs) were then compared between the two treatment planning systems. Winston-Lutz tests were carried out as routine machine QA. Patient-specific QA included ArcCheck measurement with an insert, where an ionization chamber was placed at the centre to measure dose at the isocenter. For the first several patients, and subsequently for the plans with extremely strong modulation, Gafchromic film dosimetry was also employed. For each patient, a mock setup was scheduled prior to treatments. Daily pre- and post-CBCT were acquired for setup and assessment of intra-fractional motion, respectively.

  1. The embodied and relational nature of the mind: implications for clinical interventions in aging individuals and populations

    Directory of Open Access Journals (Sweden)

    Rejeski WJ

    2013-06-01

    Full Text Available W Jack Rejeski,1 Lise Gauvin2 1Department of Health and Exercise Science and Department of Geriatric Medicine, Wake Forest University, Winston-Salem, NC, USA; 2Research Center of the University of Montréal Hospital Center, Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada Abstract: Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and information flow; they codetermine how we think, feel, and behave both individually and collectively. In addition to direct experience, evidence supports the view that stimuli embedded within past memories trigger multimodal simulations throughout the body and brain to literally recreate lived experience. In this paper, we review empirical support for the concept of an embodied and relational mind and then reflect on the implications of this perspective for clinical interventions in aging individuals and populations. Data suggest that environmental influences literally “get under the skin” with aging; that musculoskeletal and visceral sensations become more prominent in activities of the mind due to aging biological systems and chronic disease. We argue that conceiving the mind as embodied and relational will grow scientific inquiry in aging, transform how we think about the self-system and well-being, and lead us to rethink health promotion interventions aimed at aging individuals and populations. Keywords: behavior change, gerontology, disablement, well-being, embodiment

  2. Surgical travellers: tapestry to Bayeux.

    Science.gov (United States)

    Hedley-Whyte, John; Milamed, Debra R

    2014-09-01

    The planning for surgery in war was revisited in 1937 when Ian Fraser was elected a member of the Surgical Travellers. At their 1938 Surgical Travellers meeting in Vienna, Ian and Eleanor Fraser were evicted from their hotel room by the Nazis. The 1939 meeting in Belfast discussed the organization of surgery and the conduct of Emergency Medical Service Hospitals in the United Kingdom; the vast majority were to be under civilian government and military control. From 1943 lengthy and informative organizational meetings were held at least monthly under the chairmanship of Sir Alexander Hood, KBE, Head of the RAMC. Surgical Consultants, now Major Generals, Brigadiers or Full Colonels in the British and U.S. Armies stationed in the UK, prepared for the invasion of Europe. The allocation of medical, surgical, nursing and auxiliary responsibilities was delineated. Liaison with the RAF and US Army Air Force was close as it was with the proposed leaders, Ulstermen Brooke and Montgomery. Montgomery chose Arthur Porritt as Surgeon in Chief to Supreme Headquarters Allied Expeditionary Force (SHAEF), and Eisenhower, General Albert W. Kenner. Just after D-Day, Porritt met Ian Fraser, who had waded in on Arromanches Beach. The triage and evacuation plans for Allied casualties had been controversial, particularly as regards Landing Ship Tanks (LSTs). The dispute with the Hood-selected surgeons on one side, against medical and surgical deployment of LSTs, and Admiral Ernest King and Winston Churchill on the other, favouring LST use for surgery and evacuation. King and Churchill were correct but total Allied air superiority allowed wide use of many of the Allies' Dakotas; 10,000 DC-3s were eventually in service. Supported by forty Allied combat planes to each Luftwaffe, the dispute about Landing Ship Tank use in about a fortnight became moot. The multifaceted role of the Princess Royal in the Emergency Medical Services of the United Kingdom and her close liaison with the Consultant

  3. Rufinamide in patients with Lennox-Gastaut syndrome

    Directory of Open Access Journals (Sweden)

    Clark PO

    2016-11-01

    Full Text Available Peggy O Clark,1 Patricia A Gibson2 1Cincinnati Children’s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH, 2Epilepsy Information Service, Wake Forest University School of Medicine, Winston-Salem, NC, USA Objectives: Lennox–Gastaut syndrome (LGS is an epileptic encephalopathy with an onset at the age of ~4 years. LGS is notoriously difficult to manage, as most patients experience multiple seizures per day, despite their concomitant use of several antiepileptic drugs (AEDs. Rufinamide (BANZEL® is an AED approved by the US Food and Drug Administration for the adjunctive treatment of seizures associated with LGS in pediatric patients aged ≥1 year and in adults. The expert care of nurses knowledgeable in the treatment options for LGS is valuable to patients and caregivers. This review summarizes the existing knowledge on LGS and data from clinical and real-world studies on the use of rufinamide in patients with LGS.Methods: Recent review articles and information from the Epilepsy Foundation Website were reviewed for data on LGS treatment. Primary articles on rufinamide were also selected for review.Results and conclusion: The efficacy and safety of rufinamide have been evaluated in children and adults by using double-blind, open-label, and observational studies. In general, these studies indicate that rufinamide effectively reduces the frequency and severity of multiple seizure types associated with LGS and has tolerable side effects, the most common being vomiting and somnolence. Dosing modifications based on age, weight, and concomitant AED usage are recommended for patients using rufinamide. Keywords: Lennox–Gastaut syndrome, anticonvulsants, rufinamide

  4. WaterWatts : the world's only all-drainwater heat exchanger : introduction and test data

    Energy Technology Data Exchange (ETDEWEB)

    Richards, C. [Saskatchewan Univ., Saskatoon, SK (Canada). College of Engineering; MacKelvie, W. [Winston Works Inc., Knowlton, PQ (Canada)

    2005-05-02

    This document presented the innovative All-buildings, All-Drainwater Heat Exchanger, a new method of saving energy in buildings. Water heating is the second largest user of energy in buildings. The used hot water is typically just drained away to the sewer, resulting in a significant waste of energy and money. Winston Works developed and patented the WaterWatts product which uses the normally-wasted heat in the drainwater of showers, tubs and washing machines to preheat all of the cold water for the water heater. The result is greener hot water through a significant reduction in energy use and related emissions. Drainflow is not hindered in any way. The unit can be installed by removing a section of vertical or horizontal drainpipe and replacing it with WaterWatts. The water heater's cold water supply is then redirected to first go through WaterWatts. This type of drainwater heat recovery system has a drainwater heat exchanger (DWHEx) that cools the drainwater by transferring its heat to a cold water heat exchanger (CWHEx). In the horizontal WaterWatts, the DWHEx is hemicylindrical to provide a broad flat surface for the drainwater to transfer its heat to rapidly. The flat shape also provides an ideal outside surface for fins which keep the tube cold. The vertical DWHEx has the same large, straight copper tube as the competition. But unlike the competition, WaterWatts has no moving parts, uses no power, requires no maintenance, has an indefinitely long life and is easy to install with minimal capital investment. Every building where the cost of hot water is borne by the owner is a potential customer for this product, such as residences, laundromats and restaurants. This energy savings technology also works with industrial process drainwater of any composition and temperature. tabs., figs.

  5. Smoker awareness of and beliefs about supposedly less-harmful tobacco products.

    Science.gov (United States)

    O'Connor, Richard J; Hyland, Andrew; Giovino, Gary A; Fong, Geoffrey T; Cummings, K Michael

    2005-08-01

    Cigarette manufacturers in the United States have begun marketing cigarette brands claiming to reduce smokers' exposure to selected toxins in tobacco smoke. Little data exist on smokers' awareness, use, and beliefs about these products. Data from the U.S. arm of the International Tobacco Control Policy Four-Country Survey (ITC-4), a telephone survey of 2028 adult current cigarette smokers in the United States conducted between May and September 2003, were analyzed. Respondents were asked to report their awareness, beliefs, and use of products marketed as less harmful than traditional cigarettes and of smokeless tobacco (SLT) products. Close to 39% of smokers were aware of "less-harmful" cigarettes, but only 27% of them could name a specific brand of such cigarettes. The brand named most often was Quest (25.7%), followed by Eclipse (7.6%), Winston (5.7%), herbal cigarettes (3.3%), "smoke-free" cigarettes (2.9%), Marlboro Blend #27 (1.9%), and Omni (1.9%). Of those who named a brand, 25% believed such products were less harmful than "ordinary cigarettes." In contrast, 82% of cigarette smokers were aware of SLT products, but only 10.7% of these believed that SLTs were less harmful than ordinary cigarettes. Smokers hold beliefs about the relative safety of supposedly less-harmful tobacco products that are opposite to existing scientific evidence. These results highlight the need to educate smokers about the risks of alternatives to conventional cigarettes, and the need to regulate the advertising and promotion of such alternatives.

  6. Lennox-Gastaut syndrome: impact on the caregivers and families of patients.

    Science.gov (United States)

    Gibson, Patricia A

    2014-01-01

    Lennox-Gastaut syndrome (LGS) has a major impact on the health-related quality of life (HRQL) of the affected children as well as their caregivers. The primary caregiver in the family is generally the mother, with support from the father and siblings. The burden of care and the effects of the disease on the child necessitate adjustments in virtually all aspects of the lives of their family. These adjustments inevitably affect the physical, emotional, social, and financial health of the whole family. Numerous sources of support for families can help to ease the burden of care. Improvements in the treatment of LGS, in addition to helping the child with LGS, would likely help improve the HRQL of the family members. This pilot parent survey was designed to explore the impact of epilepsy on caregiver HRQL. Parents of children with epilepsy who had contacted the Epilepsy Information Service at the Wake Forest University School of Medicine, Winston-Salem, NC, USA, were sent questionnaires comprising open- and closed-ended questions. A total of 200 surveys were distributed, with a return rate of 48%. The results revealed that 74% of the parents believed that having a child with epilepsy brought them and their partner closer together. However, when the parents were asked to explain the manner in which epilepsy affected their families, answers included continuous stress, major financial distress, and lack of time to spend with other children. Information and resources for the families of children with LGS could help improve the HRQL of both the patients and their relatives.

  7. SU-G-TeP4-12: Individual Beam QA for a Robotic Radiosurgery System Using a Scintillator Cone

    Energy Technology Data Exchange (ETDEWEB)

    McGuinness, C; Descovich, M; Sudhyadhom, A [University of California San Francisco, San Francisco, CA (United States)

    2016-06-15

    Purpose: The targeting accuracy of the Cyberknife system is measured by end-to-end tests delivering multiple isocentric beams to a point in space. While the targeting accuracy of two representative beams can be determined by a Winston-Lutz-type test, no test is available today to determine the targeting accuracy of each clinical beam. We used a scintillator cone to measure the accuracy of each individual beam. Methods: The XRV-124 from Logos Systems Int’l is a scintillator cone with an imaging system that is able to measure individual beam vectors and a resulting error between planned and measured beam coordinates. We measured the targeting accuracy of isocentric and non-isocentric beams for a number of test cases using the Iris and the fixed collimator. The average difference between plan and measured beam position was 0.8–1.2mm across the collimator sizes and plans considered here. The max error for a single beam was 2.5mm for the isocentric plans, and 1.67mm for the non-isocentric plans. The standard deviation of the differences was 0.5mm or less. Conclusion: The CyberKnife System is specified to have an overall targeting accuracy for static targets of less than 0.95mm. In E2E tests using the XRV124 system we measure average beam accuracy between 0.8 to 1.23mm, with maximum of 2.5mm. We plan to investigate correlations between beam position error and robot position, and to quantify the effect of beam position errors on patient specific plans. Martina Descovich has received research support and speaker honoraria from Accuray.

  8. GISMO: A MATLAB toolbox for seismic research, monitoring, & education

    Science.gov (United States)

    Thompson, G.; Reyes, C. G.; Kempler, L. A.

    2017-12-01

    GISMO is an open-source MATLAB toolbox which provides an object-oriented framework to build workflows and applications that read, process, visualize and write seismic waveform, catalog and instrument response data. GISMO can retrieve data from a variety of sources (e.g. FDSN web services, Earthworm/Winston servers) and data formats (SAC, Seisan, etc.). It can handle waveform data that crosses file boundaries. All this alleviates one of the most time consuming part for scientists developing their own codes. GISMO simplifies seismic data analysis by providing a common interface for your data, regardless of its source. Several common plots are built-in to GISMO, such as record section plots, spectrograms, depth-time sections, event count per unit time, energy release per unit time, etc. Other visualizations include map views and cross-sections of hypocentral data. Several common processing methods are also included, such as an extensive set of tools for correlation analysis. Support is being added to interface GISMO with ObsPy. GISMO encourages community development of an integrated set of codes and accompanying documentation, eliminating the need for seismologists to "reinvent the wheel". By sharing code the consistency and repeatability of results can be enhanced. GISMO is hosted on GitHub with documentation both within the source code and in the project wiki. GISMO has been used at the University of South Florida and University of Alaska Fairbanks in graduate-level courses including Seismic Data Analysis, Time Series Analysis and Computational Seismology. GISMO has also been tailored to interface with the common seismic monitoring software and data formats used by volcano observatories in the US and elsewhere. As an example, toolbox training was delivered to researchers at INETER (Nicaragua). Applications built on GISMO include IceWeb (e.g. web-based spectrograms), which has been used by Alaska Volcano Observatory since 1998 and became the prototype for the USGS

  9. SU-E-T-282: Dose Measurements with An End-To-End Audit Phantom for Stereotactic Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R; Artschan, R [Calvary Mater Newcastle, Newcastle, NSW (Australia); Thwaites, D [University of Sydney, Sydney, NSW (Australia); Lehmann, J [Calvary Mater Newcastle, Newcastle, NSW (Australia); University of Sydney, Sydney, NSW (Australia)

    2015-06-15

    Purpose: Report on dose measurements as part of an end-to-end test for stereotactic radiotherapy, using a new audit tool, which allows audits to be performed efficiently either by an onsite team or as a postal audit. Methods: Film measurements have been performed with a new Stereotactic Cube Phantom. The phantom has been designed to perform Winston Lutz type position verification measurements and dose measurements in one setup. It comprises a plastic cube with a high density ball in its centre (used for MV imaging with film or EPID) and low density markers in the periphery (used for Cone Beam Computed Tomography, CBCT imaging). It also features strategically placed gold markers near the posterior and right surfaces, which can be used to calculate phantom rotations on MV images. Slit-like openings allow insertion of film or other detectors.The phantom was scanned and small field treatment plans were created. The fields do not traverse any inhomogeneities of the phantom on their paths to the measurement location. The phantom was setup at the delivery system using CBCT imaging. The calculated treatment fields were delivered, each with a piece of radiochromic film (EBT3) placed in the anterior film holder of the phantom. MU had been selected in planning to achieve similar exposures on all films. Calibration films were exposed in solid water for dose levels around the expected doses. Films were scanned and analysed following established procedures. Results: Setup of the cube showed excellent suitability for CBCT 3D alignment. MV imaging with EPID allowed for clear identification of all markers. Film based dose measurements showed good agreement for MLC created fields down to 0.5 mm × 0.5 mm. Conclusion: An end-to-end audit phantom for stereotactic radiotherapy has been developed and tested.

  10. Particulate matter emissions of different brands of mentholated cigarettes.

    Science.gov (United States)

    Gerharz, Julia; Bendels, Michael H K; Braun, Markus; Klingelhöfer, Doris; Groneberg, David A; Mueller, Ruth

    2018-01-09

    Inhaling particulate matter (PM) in environmental tobacco smoke (ETS) endangers the health of nonsmokers. Menthol, an additive in cigarettes, attenuates respiratory irritation of tobacco smoke. It reduces perceptibility of smoke and therefore passive smokers may inhale ETS unnoticed. To investigate a possible effect of menthol on PM concentrations (PM 10 , PM 2.5 , and PM 1 ), ETS of four mentholated cigarette brands (Elixyr Menthol, Winston Menthol, Reyno Classic, and Pall Mall Menthol Blast) with varying menthol content was analyzed. ETS was generated in a standardized way using an automatic environmental tobacco smoke emitter (AETSE), followed by laser aerosol spectrometry. This analysis shows that the tested cigarette brands, despite having different menthol concentrations, do not show differences with regard to PM emissions, with the exception of Reyno Classic, which shows an increased emission, although the menthol level ranged in the midfield. More than 90% of the emitted particles had a size smaller than or equal to 1 µm. Regardless of the menthol level, the count median diameter (CMD) and the mass median diameter (MMD) were found to be 0.3 µm and 0.5 µm, respectively. These results point out that there is no effect of menthol on PM emission and that other additives might influence the increased PM emission of Reyno Classic. Particulate matter (PM) in ETS endangers the health of nonsmokers and smokers. This study considers the effect of menthol, an additive in cigarettes, on PM emissions. Does menthol increase the amount of PM? Due to the exposure to secondhand smoke nearly 900,000 people die each year worldwide. The aim of the study is to measure the particle concentration (L -1 ), mass concentration (µg m -3 ), and dust mass fractions shown as PM 10 , PM 2.5 , and PM 1 of five different cigarette brands, including four with different menthol concentrations and one menthol-free reference cigarette, in a well-established standardized system.

  11. “And they told two friends…and so on”: RJ Reynolds’ viral marketing of Eclipse and its potential to mislead the public

    Science.gov (United States)

    Anderson, S J; Ling, P M

    2010-01-01

    Objective To explore viral marketing strategies for Eclipse cigarettes used by the RJ Reynolds Company (Winston-Salem, North Carolina, USA). Methods Analysis of previously secret tobacco industry documents and multimedia materials. Results The failure of RJ Reynolds’ (RJR) 1988 “smokeless” cigarette, Premier, was in part due to widespread bad word of mouth about the product’s flavour, quality and difficulty of use. In 1994 RJR introduced an updated version of Premier, the ostensibly “reduced risk” Eclipse cigarette. RJR developed viral marketing channels to promote Eclipse using (1) exploratory interviews to motivate consumers to spread the word about Eclipse prior to market release, (2) promotional videos featuring positive feedback from test group participants to portray majority consensus among triers, (3) “Tupperware”-like parties for Eclipse where participants received samples to pass around in their social circles and (4) the Eclipse website’s bulletin board as a forum for potential users to discuss the brand in their own words. These strategies targeted the brand’s likeliest adopters, recruited informal and credible representatives of the product unaffiliated with RJR, and controlled the information spread about the product. Conclusions Viral marketing techniques may be particularly useful to promote new tobacco products such as Eclipse that have limited appeal and need a highly motivated audience of early adopters and acceptors. Such techniques help evade the mass rejection that could follow mass promotion, circumvent marketing restrictions, and allow tobacco companies to benefit from health claims made by consumers. Cigarette manufacturers must be held accountable for perceived health benefits encouraged by all promotional activities including viral marketing. PMID:18332064

  12. ''Atomic Optics'': Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as ''nonimaging optics''. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  13. Earthworm in the 21st century

    Science.gov (United States)

    Friberg, Paul; Lisowski, Stefan; Dricker, Ilya; Hellman, Sidney

    2010-05-01

    Earthworm (Johnson et al., 1995) is a fully open-source earthquake data acquisition and processing package that is in widespread use through out the world. Earthworm includes basic seismic data acquistion for the majority of the dataloggers currently available and provides network transport mechanisms and common formats as output for data transferral. In addition, it comes with network seismology tools to compute network detections, perform automated arrival picking, and automated hypocentral and magnitude estimations. More importantly it is an open and free framework in the C-programming language that can be used to create new modules that process waveform and earthquake data in near real time. The number of Earthworm installations is growing annually as are the number of contributions to the system. Furthermore its growth into other areas of waveform data acquistion (namely Geomagnetic observatories and Infrasound arrays) show its adaptability to other waveform technologies and processing strategies. In this presentation we discuss the coming challenges to growing Earthworm and new developments in its use; namely the open source add-ons that have become interfaces to Earthworm's core. These add-ons include GlowWorm, MagWorm, Hydra, SWARM, Winston, EarlyBird, Iworm, and most importantly, AQMS (formerly known as CHEETAH). The AQMS, ANSS Quake Monitoring System, is the Earthworm system created in California which has now been installed in the majority of Regional Seismic Networks (RSNs) in the United States. AQMS allows additional real-time and post-processing of Earthworm generated data to be stored and manipulated in a database using numerous database oriented tools. The use of a relational database for persistence provides users with the ability to implement configuration control and research capabilities not available in earlier Earthworm add-ons. By centralizing on AQMS, the RSNs will be able to leverage new developments by easily sharing Earthworm and AQMS

  14. A Multi-Center Diabetes Eye Screening Study in Community Settings: Study Design and Methodology.

    Science.gov (United States)

    Murchison, Ann P; Friedman, David S; Gower, Emily W; Haller, Julia A; Lam, Byron L; Lee, David J; McGwin, Gerald; Owsley, Cynthia; Saaddine, Jinan; Insight Study Group

    2016-01-01

    Diabetes is the leading cause of new cases of blindness among adults aged 20-74 years within the United States. The Innovative Network for Sight Research group (INSIGHT) designed the Diabetic Eye Screening Study (DESS) to examine the feasibility and short-term effectiveness of non-mydriatic diabetic retinopathy (DR) screening for adults with diabetes in community-based settings. Study enrollment began in December 2011 at four sites: an internal medicine clinic at a county hospital in Birmingham, Alabama; a Federally-qualified community healthcare center in Miami-Dade County, Florida; a university-affiliated outpatient pharmacy in Philadelphia, Pennsylvania; and a medical home in Winston-Salem, North Carolina. People 18 years or older with previously diagnosed diabetes were offered free DR screening using non-mydriatic retinal photography that was preceded by a brief questionnaire addressing demographic information and previous eye care use. Visual acuity was also measured for each eye. Images were evaluated at a telemedicine reading center by trained evaluators using the National Health System DR grading classification. Participants and their physicians were sent screening report results and telephoned for a follow-up survey 3 months post-screening to determine whether participants had sought follow-up comprehensive eye care and their experiences with the screening process. Target enrollment at each site was a minimum of 500 persons. Three of the four sites met this enrollment goal. The INSIGHT/DESS is intended to establish the feasibility and short-term effectiveness of DR screening using non-mydriatic retinal photography in persons with diabetes who seek services in community-based clinic and pharmacy settings.

  15. SU-E-T-54: A New Method for Optimizing Radiation Isocenter for Linac-Based SRS

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, S [Southeast Missouri Hospital, Cape Girardeau, MO (United States); Hyer, D; Nixon, E [University Of Iowa, Iowa City, IA (United States)

    2015-06-15

    Purpose: To develop a new method to minimize deviation of linac x-ray beams from the centroid of the volumetric radiation isocenter for all combinations of gantry and table angle. Methods: A set of ball-bearing (Winston-Lutz) images was used to determine the gantry radiation isocenter as the midrange of deviation values. Deviations in the cross-plane direction were minimized by calibration of MLC leaf position offset, and by adjusting beam position steering for each energy. Special attention was also paid to matching the absolute position of isocenter across all energies by adjusting position steering in the gun-target axis. Displacement of table axis from the gantry isocenter, and recommended table axis adjustment for contemporary Elekta linacs, was also determined. Eight images were used to characterize the volumetric isocenter for the full range of gantry and table rotations available. Tabulation of deviation for each beam was used to test compliance with isocenter tolerance. Results: Four contemporary Elekta linacs were evaluated and the radius in the gun-target axis of the radiation isocenter was 0.5 to 0.7 mm. After beam steering adjustment, the radius in the cross-plane direction was typically 0.2 to 0.4 mm. Position matching between energies can be reduced to 0.28 mm. Maximum total deviation was 0.68 to 1.07 mm, depending primarily on the effect of systematic table axis wobble with rotation. Conclusion: This new method effectively facilitates minimization of deviation between beam center and target position. The test, which requires a few minutes to perform, can be easily incorporated into a routine machine QA program. A tighter radiation isocenter for contemporary Elekta linacs would require reducing the effect of gantry arm flex and/or table axis wobble that are the two main components of deviation from the designated isocenter point.

  16. Quantifying the gantry sag on linear accelerators and introducing an MLC-based compensation strategy

    Energy Technology Data Exchange (ETDEWEB)

    Du Weiliang; Gao Song; Wang Xiaochun; Kudchadker, Rajat J. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2012-04-15

    Purpose: Gantry sag is one of the well-known sources of mechanical imperfections that compromise the spatial accuracy of radiation dose delivery. The objectives of this study were to quantify the gantry sag on multiple linear accelerators (linacs), to investigate a multileaf collimator (MLC)-based strategy to compensate for gantry sag, and to verify the gantry sag and its compensation with film measurements. Methods: The authors used the Winston-Lutz method to measure gantry sag on three Varian linacs. A ball bearing phantom was imaged with megavolt radiation fields at 10 deg. gantry angle intervals. The images recorded with an electronic portal imaging device were analyzed to derive the radiation isocenter and the gantry sag, that is, the superior-inferior wobble of the radiation field center, as a function of the gantry angle. The authors then attempted to compensate for the gantry sag by applying a gantry angle-specific correction to the MLC leaf positions. The gantry sag and its compensation were independently verified using film measurements. Results: Gantry sag was reproducible over a six-month measurement period. The maximum gantry sag was found to vary from 0.7 to 1.0 mm, depending on the linac and the collimator angle. The radiation field center moved inferiorly (i.e., away from the gantry) when the gantry was rotated from 0 deg. to 180 deg. After the MLC leaf position compensation was applied at 90 deg. collimator angle, the maximum gantry sag was reduced to <0.2 mm. The film measurements at gantry angles of 0 deg. and 180 deg. verified the inferior shift of the radiation fields and the effectiveness of MLC compensation. Conclusions: The results indicate that gantry sag on a linac can be quantitatively measured using a simple phantom and an electronic portal imaging device. Reduction of gantry sag is feasible by applying a gantry angle-specific correction to MLC leaf positions at 90 deg. collimator angle.

  17. SU-G-TeP2-04: Comprehensive Machine Isocenter Evaluation with Separation of Gantry, Collimator, and Table Variables

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, S [Southeast Missouri Hospital, Cape Girardeau, MO (United States); Clements, C [Radiological Imaging Technology, Colorado Springs, CO (United States); Hyer, D; Nixon, E [University Of Iowa, Iowa City, IA (United States); Martin, E; Wang, B [University of Louisville, Louisville, KY (United States); Jani, S [Sharp Memorial Hospital, San Diego, CA (United States); Gossman, M [Tri-State Regional Cancer Center, Ashland, KY (United States)

    2016-06-15

    Purpose: To develop and demonstrate application of a method that characterizes deviation of linac x-ray beams from the centroid of the volumetric radiation isocenter as a function of gantry, collimator, and table variables. Methods: A set of Winston-Lutz ball-bearing images was used to determine the gantry radiation isocenter as the midrange of deviation values resulting from gantry and collimator rotation. Also determined were displacement of table axis from gantry isocenter and recommended table axis adjustment. The method, previously reported, has been extended to include the effect of collimator walkout by obtaining measurements with 0 and 180 degree collimator rotation for each gantry angle. Twelve images were used to characterize the volumetric isocenter for the full range of available gantry, collimator, and table rotations. Results: Three Varian True Beam, two Elekta Infinity and four Versa HD linacs at five institutions were tested using identical methodology. Varian linacs exhibited substantially less deviation due to head sag than Elekta linacs (0.4 mm vs. 1.2 mm on average). One linac from each manufacturer had additional isocenter deviation of 0.3 to 0.4 mm due to jaw instability with gantry and collimator rotation. For all linacs, the achievable isocenter tolerance was dependent on adjustment of collimator position offset, transverse position steering, and alignment of the table axis with gantry isocenter, facilitated by these test results. The pattern and magnitude of table axis wobble vs. table angle was reproducible and unique to each machine. Conclusion: This new method provides a comprehensive set of isocenter deviation values including all variables. It effectively facilitates minimization of deviation between beam center and target (ball-bearing) position. This method was used to quantify the effect of jaw instability on isocenter deviation and to identify the offending jaw. The test is suitable for incorporation into a routine machine QA

  18. Self-Expandable Metal Stent for Closure of a Large Leak after Total Gastrectomy

    Directory of Open Access Journals (Sweden)

    G. Curcio

    2010-08-01

    Full Text Available In recent years, self-expandable metallic stents (SEMSs have emerged as a promising treatment alternative for the bridging and sealing of esophageal perforations and extensive anastomotic leaks after esophageal resection or total gastrectomy. A 56-year-old woman underwent a total gastrectomy with Roux-en-Y end-to-side esophagojejunostomy for a gastric signet ring cell carcinoma. Ten days later, esophagogastroduodenoscopy showed a 2 cm fistula in the distal end of the Roux limb of the anastomosis. This was confirmed by gastrografin esophagography. The patient was started on total parenteral nutrition. Having deemed clipping treatment for this fistula unfeasible, we decided to insert a partially silicone-coated SEMS (Evolution Controlled Release Esophageal Stent System, Cook Medical, Winston-Salem, N.C., USA. The stent was removed after ten days. Gastrografin esophagography showed no further contrast extravasation, and esophagogastroduodenoscopy showed closure of the fistula. No clinical complications were observed, and the patient was able to start normal per os nutrition. In conclusion, the treatment of symptomatic leaks in patients who have undergone esophagojejunostomy is challenging, and leakage from the jejunal stump can be a potentially serious complication. In the treatment of leakage after total gastrectomy, plastic stents (which are either too light or exercise too little radial force and totally covered metallic stents may not adhere sufficiently to the esophagojeujunal walls and, as a result, migrate beyond the anastomosis. The promising results of this report suggest that early stenting, using a partially silicone-coated SEMS, is a feasible alternative to surgical treatment in this category of patients.

  19. A novel hemostatic powder for upper gastrointestinal bleeding: a multicenter study (the "GRAPHE" registry).

    Science.gov (United States)

    Haddara, Sami; Jacques, Jeremie; Lecleire, Stéphane; Branche, Julien; Leblanc, Sarah; Le Baleur, Yann; Privat, Jocelyn; Heyries, Laurent; Bichard, Philippe; Granval, Philippe; Chaput, Ulriikka; Koch, Stephane; Levy, Jonathan; Godart, Bruno; Charachon, Antoine; Bourgaux, Jean-François; Metivier-Cesbron, Elodie; Chabrun, Edouard; Quentin, Vincent; Perrot, Bastien; Vanbiervliet, Geoffroy; Coron, Emmanuel

    2016-12-01

    Background and study aims: The hemostatic powder TC-325 (Hemospray; Cook Medical, Winston-Salem, North Carolina, USA) has shown promising results in the treatment of upper gastrointestinal bleeding (UGIB) in expert centers in pilot studies. The aim of this study was to evaluate the feasibility and efficacy of TC-325 in a large prospective registry of use in routine practice. Patients and methods: The data of all patients treated with TC-325 were prospectively collected through a national registry. Outcomes were the immediate feasibility and efficacy of TC-325 application, as well as the rates of rebleeding at Day 8 and Day 30. Multivariate analysis was performed to determine predictive factors of rebleeding. Results: A total of 202 patients were enrolled and 64 endoscopists participated from 20 centers. TC-325 was used as salvage therapy in 108 patients (53.5 %). The etiology of bleeding was an ulcer in 75 patients (37.1 %), tumor in 61 (30.2 %), postendoscopic therapy in 35 (17.3 %), or other in 31 (15.3 %). Application of the hemostatic powder was found to be very easy or easy in 31.7 % and 55.4 %, respectively. The immediate efficacy rate was 96.5 %. Recurrence of UGIB was noted at Day 8 and Day 30 in 26.7 % and 33.5 %, respectively. Predictive factors of recurrence at Day 8 were melena at initial presentation and use of TC-325 as salvage therapy. Conclusion: These multicenter data confirmed the high rate of immediate hemostasis, excellent feasibility, and good safety profile of TC-325, which could become the treatment of choice in bleeding tumors or postendoscopic bleeding but not in bleeding ulcers where randomized studies are needed. ClinicalTrials.gov (NCT02595853). © Georg Thieme Verlag KG Stuttgart · New York.

  20. Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections

    Directory of Open Access Journals (Sweden)

    Jones TM

    2016-06-01

    Full Text Available Travis M Jones,1,2 Steven W Johnson,1,3 V Paul DiMondi,1,4 Dustin T Wilson,1,2 1Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, 2Department of Pharmacy, Duke University Hospital, Durham, 3Department of Pharmacy, Forsyth Medical Center, Novant Health, Winston-Salem, 4Department of Pharmacy, Durham VA Medical Center, Durham, NC, USA Abstract: JNJ-Q2 is a novel, fifth-generation fluoroquinolone that has excellent in vitro and in vivo activity against a variety of Gram-positive and Gram-negative organisms. In vitro studies indicate that JNJ-Q2 has potent activity against pathogens responsible for acute bacterial skin and skin structure infections (ABSSSI and community-acquired bacterial pneumonia (CABP, such as Staphylococcus aureus and Streptococcus pneumoniae. JNJ-Q2 also has been shown to have a higher barrier to resistance compared to other agents in the class and it remains highly active against drug-resistant organisms, including methicillin-resistant S. aureus, ciprofloxacin-resistant methicillin-resistant S. aureus, and drug-resistant S. pneumoniae. In two Phase II studies, the efficacy of JNJ-Q2 was comparable to linezolid for ABSSSI and moxifloxacin for CABP. Furthermore, JNJ-Q2 was well tolerated, with adverse event rates similar to or less than other fluoroquinolones. With an expanded spectrum of activity and low potential for resistance, JNJ-Q2 shows promise as an effective treatment option for ABSSSI and CABP. Considering its early stage of development, the definitive role of JNJ-Q2 against these infections and its safety profile will be determined in future Phase III studies. Keywords: JNJ-Q2, fluoroquinolone, ABSSSI, CABP, MRSA

  1. SU-G-TeP4-12: Individual Beam QA for a Robotic Radiosurgery System Using a Scintillator Cone

    International Nuclear Information System (INIS)

    McGuinness, C; Descovich, M; Sudhyadhom, A

    2016-01-01

    Purpose: The targeting accuracy of the Cyberknife system is measured by end-to-end tests delivering multiple isocentric beams to a point in space. While the targeting accuracy of two representative beams can be determined by a Winston-Lutz-type test, no test is available today to determine the targeting accuracy of each clinical beam. We used a scintillator cone to measure the accuracy of each individual beam. Methods: The XRV-124 from Logos Systems Int’l is a scintillator cone with an imaging system that is able to measure individual beam vectors and a resulting error between planned and measured beam coordinates. We measured the targeting accuracy of isocentric and non-isocentric beams for a number of test cases using the Iris and the fixed collimator. The average difference between plan and measured beam position was 0.8–1.2mm across the collimator sizes and plans considered here. The max error for a single beam was 2.5mm for the isocentric plans, and 1.67mm for the non-isocentric plans. The standard deviation of the differences was 0.5mm or less. Conclusion: The CyberKnife System is specified to have an overall targeting accuracy for static targets of less than 0.95mm. In E2E tests using the XRV124 system we measure average beam accuracy between 0.8 to 1.23mm, with maximum of 2.5mm. We plan to investigate correlations between beam position error and robot position, and to quantify the effect of beam position errors on patient specific plans. Martina Descovich has received research support and speaker honoraria from Accuray

  2. Critical appraisal of the Spanner™ prostatic stent in the treatment of prostatic obstruction

    Directory of Open Access Journals (Sweden)

    Patrick McKenzie

    2011-02-01

    Full Text Available Patrick McKenzie1, Gopal Badlani11Department of Urology, Wake Forest University School of Medicine, Winston-Salem NC, USAAbstract: The Spanner™ stent was first used in patients to relieve bladder outlet obstruction (BOO, and has recently been used in patients following transurethral microwave thermotherapy and men unfit for surgical intervention. We review the current literature on the role of the Spanner stent in treating prostatic obstruction compared to previously reported cases involving the use of temporary stents. The Spanner stent has been found to be successful in treating patients with bladder outlet obstruction from benign prostatic hyperplasia and following high-energy transurethral microwave thermotherapy (TUMT. Patients with the Spanner stent had an increase in peak flow rate and a decrease in post void residual and International Prostate Symptom Scores. In patients treated with TUMT, quality of life measures indicate that the Spanner stent shows increased ease of bladder drainage, decreased leakage, and no adverse effect on daily activities. In patients unfit for surgery, however, there was increased retention and pain requiring stent removal in 63% of cases. The Spanner stent offers ease of insertion with a decrease in voiding symptoms in selected patients. Based on limited data, the Spanner stent has been recommended as a treatment option for men with BOO following TUMT. However, it is not a good treatment option for men unfit for surgery based on an increased incidence of urinary retention and dysuria. The Spanner stent is the only currently approved temporary stent and, based on a literature review, it does not offer significant advantage over previously used temporary stents. It is notable that most researchers have not evaluated the role of detrusor function on the outcomes.Keywords: benign prostate hyperplasia, Spanner stent, urethral stent, minimally invasive therapy

  3. Verifying influenza and pneumococcal immunization status of children in 2009-2010 from primary care practice records and from the North Carolina Immunization Registry.

    Science.gov (United States)

    Poehling, Katherine A; Vannoy, Lauren; Peters, Timothy R

    2013-01-01

    The North Carolina Immunization Registry (NCIR) has been available since 2004. We sought to measure its utilization among practices that provide primary care for children who are enrolled in a prospective influenza surveillance study. This study included children aged 0.5-17 years who presented with fever or acute respiratory symptoms to an emergency department or inpatient setting in Winston-Salem, North Carolina, from September 1, 2009, through May 19, 2010. Study team members verified influenza and pneumococcal immunization status by requesting records from each child's primary care practice and by independently reviewing the NCIR. We assessed agreement of nonregistry immunization medical records with NCIR data using the kappa statistic. Fifty-six practices confirmed the immunization status of 292 study-enrolled children. For most children (238/292, 82%), practices verified the child's immunizations by providing a copy of the NCIR record. For 54 children whose practices verified their immunizations by providing practice records alone, agreement with the NCIR by the kappa statistic was 0.6-0.7 for seasonal and monovalent H1N1 influenza vaccines and 0.8-0.9 for pneumococcal conjugate and polysaccharide vaccines. A total of 221 (98%) of 226 enrolled children younger than 6 years of age had 2 or more immunizations documented in the NCIR. NCIR usage may vary in other regions of North Carolina. More than 95% of children younger than 6 years of age had 2 or more immunizations documented in the NCIR; thus, the Centers for Disease Control and Prevention 2010 goal for immunization information systems was met in this population. We found substantial agreement between practice records and the NCIR for influenza and pneumococcal immunizations in children.

  4. Electromagnetic Field Devices and Their Effects on Nociception and Peripheral Inflammatory Pain Mechanisms.

    Science.gov (United States)

    Ross, Christina L; Teli, Thaleia; Harrison, Benjamin S

    2016-03-01

    Context • During cell-communication processes, endogenous and exogenous signaling affects normal and pathological developmental conditions. Exogenous influences, such as extra-low-frequency (ELF) electromagnetic fields (EMFs) have been shown to affect pain and inflammation by modulating G-protein coupling receptors (GPCRs), downregulating cyclooxygenase-2 (Cox-2) activity, and downregulating inflammatory modulators, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) as well as the transcription factor nuclear factor kappa B (NF-κB). EMF devices could help clinicians who seek an alternative or complementary treatment for relief of patients chronic pain and disability. Objective • The research team intended to review the literature on the effects of EMFs on inflammatory pain mechanisms. Design • We used a literature search of articles published in PubMed using the following key words: low-frequency electromagnetic field therapy, inflammatory pain markers, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), opioid receptors, G-protein coupling receptors, and enzymes. Setting • The study took place at the Wake Forest School of Medicine in Winston-Salem, NC, USA. Results • The mechanistic pathway most often considered for the biological effects of EMF is the plasma membrane, across which the EMF signal induces a voltage change. Oscillating EMF exerts forces on free ions that are present on both sides of the plasma membrane and that move across the cell surface through transmembrane proteins. The ions create a forced intracellular vibration that is responsible for phenomena such as the influx of extracellular calcium (Ca2+) and the binding affinity of calmodulin (CaM), which is the primary transduction pathway to the secondary messengers, cAMP and cGMP, which have been found to influence inflammatory pain. Conclusions • An emerging body of evidence indicates the existence of a frequency

  5. Source apportionment of sulfate and nitrate particulate matter in the Eastern United States and effectiveness of emission control programs.

    Science.gov (United States)

    Zhang, Hongliang; Hu, Jianlin; Kleeman, Michael; Ying, Qi

    2014-08-15

    Reducing population exposure to PM2.5 in the eastern US will require control of secondary sulfate and nitrate. A source-oriented Community Multi-scale Air Quality (CMAQ) model is used to determine contributions of major emission sources to nitrate and sulfate concentrations in the seven eastern US cities (New York City, Pittsburgh, Baltimore, Chicago, Detroit, St. Paul, and Winston-Salem) in January and August of 2000 and 2006. Identified major nitrate sources include on-road gasoline-powered vehicles, diesel engines, natural gas and coal combustion. From 2000 to 2006, January nitrate concentrations decreased by 25-68% for all the seven cities. On average, ~53% of this change was caused by emissions controls while 47% was caused by meteorology variations. August nitrate concentrations decreased by a maximum of 68% in New York City but Detroit experienced increasing August nitrate concentrations by up to 33%. On average, ~33% of the reduction in nitrate is offset by increases associated with meteorological conditions that favor nitrate formation. Coal combustion and natural gas are the dominant sources for sulfate in both seasons. January sulfate decrease from 2000 to 2006 in all cities by 4-58% except New York City, which increases by 13%. On average, ~93% of the reduction in sulfate was attributed to emission controls with 7% associated with changes in meteorology. August sulfate concentrations decrease by 11-44% in all cities. On average, emission controls alone between 2000 and 2006 would have caused 6% more reduction but the effectiveness of the controls was mitigated by meteorology conditions more favorable to sulfate production in 2006 vs. 2000. The results of this study suggest that regional emissions controls between 2000 and 2006 have been effective at reducing population exposure to PM2.5 in the eastern US, but yearly variations in meteorology must be carefully considered when assessing the exact magnitude of the control benefits. Copyright © 2014

  6. A longitudinal study of externally visible cigarette advertising on retail storefronts in Massachusetts before and after the Master Settlement Agreement.

    Science.gov (United States)

    Celebucki, Carolyn C; Diskin, K

    2002-06-01

    To assess the effect of the Master Settlement Agreement (MSA) on the amount of cigarette advertisements visible from outside of over-the-counter tobacco retailers, for five specific premium brands and an "all other" category, for five types of establishments, and in three areas (windows/doors, building/other detached areas, and sidewalks); to assess the relation of total exterior retail cigarette advertising to illegal sales to youth. Observations were conducted on the number of cigarette advertisements visible from outside tobacco retail establishments in a paired convenience sample (n = 556) in Massachusetts before and after the MSA. Archival databases containing information on merchant compliance with age related sales laws during the time period were used to assess the relation of total cigarette advertising with sales to underage youth. Paired sample t tests assessed planned comparisons pre- to post-MSA; Spearman's rho tested associations for dichotomous variables. Significant post-ban increases were observed in the prevalence of exterior cigarette advertising on gas (petrol) stations and gas mini/marts (gasoline retailers) buildings, windows, and doors. Significant declines were observed on windows of liquor stores. Winston advertising declined overall, while advertisements of the "all other" brand category increased. Correlations between advertising and illegal sales, while modest, were significant. These pre- to post-MSA increases suggest the tobacco industry may be shifting expenditures selectively from billboard advertising to retailer exteriors more favoured by youth. Greater amount of cigarette advertising visible from outside over-the-counter tobacco retailers is associated with greater cigarette sales to minors.

  7. PREFACE: 11th International Conference on Nucleus-Nucleus Collisions (NN2012)

    Science.gov (United States)

    Li, Bao-An; Natowitz, Joseph B.

    2013-03-01

    Nuclear Science and Technologies 6. Nuclear Reactions and Structure of Unstable Nuclei 7. Equation of State of Neutron-Rich Nuclear Matter, Clusters in Nuclei and Nuclear Reactions 8. Fusion and Fission 9. Nuclear Astrophysics 10. New Facilities and Detectors We would like to thank Texas A&M University and Texas A&M University-Commerce for their organizational support and for providing financial support for many students and postdocs and those who had special need. This support helped assure the success of NN2012. Special thanks also go to all members of the International Advisory Committee and the Local Organizing Committee (listed below) for their great work in advising upon, preparing and executing the NN2012 scientific program as well as the social events that all together made the NN2012 an enjoyable experience for both the participants and their companions. NN2012 International Advisory Committee N Auerbach (Israel) J Aysto (Finland) C Beck (France) S Cherubini (Italy) L Ferreira (Portugal) C Gagliardi (USA) S Gales (France) C Gale (Canada) W Gelletly (Great Britain) Paulo R S Gomes (Brazil) W Greiner (Germany) W Henning (USA) D Hinde (Australia) S Hofmann (Germany) M Hussein (Brazil) B Jacak (USA) S Kailas (India) W G Lynch (USA) Z Majka (Poland) L McLerran (USA) V Metag (Germany) K Morita (Japan) B Mueller (USA) D G Mueller (France) T Motobayashi (Japan) W Nazarewicz (USA) Y Oganessian (Russia) J Nolen (USA) E K Rehm (USA) N Rowley (France) B Sherrill (USA) J Schukraft (Switzerland) W Q Shen (China) A Stefanini (Italy) H Stoecker (Germany) A Szanto de Toledo (Brazil) U van Kolck (USA) W von Oertzen (Germany) M Wiescher (USA) N Xu (USA) N V Zamfir (Romania) W L Zhan (China) H Q Zhang (China) NN2012 Local Organizing Committee Marina Barbui Carlos Bertulani Robert Burch Jr Cheri Davis Cody Folden Kris Hagel John Hardy Bao-An Li (Co-Chair and Scientific Secretary) Joseph Natowitz (Co-Chair) Ralf Rapp Livius Trache Sherry Yennello Editors of NN2012 Proceedings Bao

  8. Barriers and facilitators associated with colonoscopy completion in individuals with multiple chronic conditions: a qualitative study

    Directory of Open Access Journals (Sweden)

    Sultan S

    2017-05-01

    Full Text Available Shahnaz Sultan,1–4 Melissa R Partin,1,2 Phalgoon Shah,5 Jennifer LeLaurin,4 Ivette Magaly Freytes,4 Chandylen L Nightingale,6 Susan F Fesperman,4 Barbara A Curbow,7 Rebecca J Beyth3,4,8 1Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Health Care System, 2Department of Medicine, University of Minnesota, Minneapolis, MN, 3Department of Medicine, University of Florida College of Medicine, Gainesville, FL, 4Center of Innovation on Disability and Rehabilitation Research, North Florida/South Georgia Veterans Health System, Gainesville, FL, 5Department of Medicine, Tripler Army Medical Center, Honolulu, HI, 6Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem NC, 7Department of Community and Behavioral Health, University of Maryland, College Park, MD, 8Geriatric Research, Education and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA Background: A recommendation to undergo a colonoscopy, an invasive procedure that requires commitment and motivation, planning (scheduling and finding a driver and preparation (diet restriction and laxative consumption, may be uniquely challenging for individuals with multiple chronic conditions (MCCs. This qualitative study aimed to describe the barriers and facilitators to colonoscopy experienced by such patients.Materials and methods: Semistructured focus groups were conducted with male Veterans who were scheduled for outpatient colonoscopy and either failed to complete the procedure or completed the examination. Focus group recordings were transcribed and analyzed by an inductive grounded approach using constant comparative analysis.Results: Forty-four individuals aged 51–83 years participated in this study (23 adherent and 21 nonadherent. Participants had an average of 7.4 chronic conditions (range 2–14. The five most common chronic conditions were hypertension (75%, hyperlipidemia (75

  9. Depression and frailty in later life: a systematic review

    Directory of Open Access Journals (Sweden)

    Vaughan L

    2015-12-01

    Full Text Available Leslie Vaughan,1 Akeesha L Corbin,1 Joseph S Goveas2 1Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, MI, USA Abstract: Frailty and depression are important issues affecting older adults. Depressive syndrome may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews on the topic include studies with wide methodological variation. This review examined the published literature on cross-sectional and longitudinal associations between frailty and depressive symptomatology with either syndrome as the outcome, moderators of this relationship, construct overlap, and related medical and behavioral interventions. Prevalence of both was reported. A systematic review of studies published from 2000 to 2015 was conducted in PubMed, the Cochrane Database of Systematic Reviews, and PsychInfo. Key search terms were “frailty”, “frail”, “frail elderly”, “depressive”, “depressive disorder”, and “depression”. Participants of included studies were ≥55 years old and community dwelling. Included studies used an explicit biological definition of frailty based on Fried et al’s criteria and a screening measure to identify depressive symptomatology. Fourteen studies met the inclusion/exclusion criteria. The prevalence of depressive symptomatology, frailty, or their co-occurrence was greater than 10% in older adults ≥55 years old, and these rates varied widely, but less in large epidemiological studies of incident frailty. The prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive. The presence of comorbidities that interact with depressive symptomatology increased incident frailty risk. Measurement variability of depressive symptomatology and inclusion of older adults

  10. An observational feasibility study to assess the safety and effectiveness of intranasal fentanyl for radiofrequency ablations of the lumbar facet joints

    Directory of Open Access Journals (Sweden)

    Bartoszek MW

    2017-02-01

    Full Text Available Michael W Bartoszek,1 Amy McCoart,2 Kyung-soo Jason Hong,3 Chelsey Haley,2 Krista Beth Highland,4 Anthony R Plunkett1 1Department of Anesthesiology, Womack Army Medical Center, Fort Bragg, NC, 2Clinical Investigations, Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Womack Army Medical Center, Fort Bragg, NC, 3Research Department, The Center for Clinical Research, Sceptor Pain Foundation, Winston Salem, NC, 4Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Uniformed Services University, Bethesda, MD, USA Purpose: The purpose of the present observational, feasibility study is to assess the preliminary safety and effectiveness of intranasal fentanyl for lumbar facet radiofrequency ablation procedures.Patients and methods: This cohort observational study included 23 adult patients. Systolic and diastolic blood pressures, heart rate, oxygen saturation percent, Pasero Opioid-Induced Sedation Scale score, and the Defense and Veterans Pain Rating Scale pain score were assessed prior to the procedure and intranasal fentanyl (100 μg administration and every 15 minutes after administration, up to 60 minutes post administration. Follow-up of patient satisfaction with pain control and treatment was assessed 24 hours after discharge. The primary outcome was safety as evidenced by adverse events. Secondary outcomes included the above-mentioned vital signs and pain ratings.Results: No adverse events occurred in the present study and all participants maintained an acceptable level of awareness throughout the assessment period. One-way repeated measures analyses of covariance tests with Bonferroni-adjusted means indicated that oxygen saturation, blood pressure, and heart rate changed from baseline, whereas pain scores were lower at post-administration levels compared with baseline. Finally, the majority of participants reported being satisfied with pain control and treatment

  11. Verification of the linac isocenter for stereotactic radiosurgery using cine-EPID imaging and arc delivery

    International Nuclear Information System (INIS)

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O' Connor, Daryl J.; Greer, Peter B.

    2011-01-01

    Purpose:Verification of the mechanical isocenter position is required as part of comprehensive quality assurance programs for stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments. Several techniques have been proposed for this purpose but each of them has certain drawbacks. In this paper, a new efficient and more comprehensive method using cine-EPID images has been introduced for automatic verification of the isocenter with sufficient accuracy for stereotactic applications. Methods: Using a circular collimator fixed to the gantry head to define the field, EPID images of a Winston-Lutz phantom were acquired in cine-imaging mode during 360 deg. gantry rotations. A robust matlab code was developed to analyze the data by finding the center of the field and the center of the ball bearing shadow in each image with sub-pixel accuracy. The distance between these two centers was determined for every image. The method was evaluated by comparison to results of a mechanical pointer and also by detection of a manual shift applied to the phantom position. The repeatability and reproducibility of the method were tested and it was also applied to detect couch and collimator wobble during rotation. Results:The accuracy of the algorithm was 0.03 ± 0.02 mm. The repeatability was less than 3 μm and the reproducibility was less than 86 μm. The time elapsed for the analysis of more than 100 cine images of Varian aS1000 and aS500 EPIDs were ∼65 and 20 s, respectively. Processing of images taken in integrated mode took 0.1 s. The output of the analysis software is printable and shows the isocenter shifts as a function of angle in both in-plane and cross-plane directions. It gives warning messages where the shifts exceed the criteria for SRS/SRT and provides useful data for the necessary adjustments in the system including bearing system and/or room lasers. Conclusions: The comprehensive method introduced in this study uses cine-images, is highly accurate, fast, and independent

  12. Design and Implementation of a Novel Web-Based E-Learning Tool for Education of Health Professionals on the Antibiotic Vancomycin.

    Science.gov (United States)

    Bond, Stuart Evan; Crowther, Shelley P; Adhikari, Suman; Chubaty, Adriana J; Yu, Ping; Borchard, Jay P; Boutlis, Craig Steven; Yeo, Wilfred Winston; Miyakis, Spiros

    2017-03-30

    gaps were identified that allowed for targeting of future education strategies. The VI provides an innovative model for delivering Web-based education to busy health professionals in different locations. ©Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.03.2017.

  13. Building groundwater modeling capacity in Mongolia

    Science.gov (United States)

    Valder, Joshua F.; Carter, Janet M.; Anderson, Mark T.; Davis, Kyle W.; Haynes, Michelle A.; Dorjsuren Dechinlhundev,

    2016-06-16

    Ulaanbaatar, the capital city of Mongolia (fig. 1), is dependent on groundwater for its municipal and industrial water supply. The population of Mongolia is about 3 million people, with about one-half the population residing in or near Ulaanbaatar (World Population Review, 2016). Groundwater is drawn from a network of shallow wells in an alluvial aquifer along the Tuul River. Evidence indicates that current water use may not be sustainable from existing water sources, especially when factoring the projected water demand from a rapidly growing urban population (Ministry of Environment and Green Development, 2013). In response, the Government of Mongolia Ministry of Environment, Green Development, and Tourism (MEGDT) and the Freshwater Institute, Mongolia, requested technical assistance on groundwater modeling through the U.S. Army Corps of Engineers (USACE) to the U.S. Geological Survey (USGS). Scientists from the USGS and USACE provided two workshops in 2015 to Mongolian hydrology experts on basic principles of groundwater modeling using the USGS groundwater modeling program MODFLOW-2005 (Harbaugh, 2005). The purpose of the workshops was to bring together representatives from the Government of Mongolia, local universities, technical experts, and other key stakeholders to build in-country capacity in hydrogeology and groundwater modeling.A preliminary steady-state groundwater-flow model was developed as part of the workshops to demonstrate groundwater modeling techniques to simulate groundwater conditions in alluvial deposits along the Tuul River in the vicinity of Ulaanbaatar. ModelMuse (Winston, 2009) was used as the graphical user interface for MODFLOW for training purposes during the workshops. Basic and advanced groundwater modeling concepts included in the workshops were groundwater principles; estimating hydraulic properties; developing model grids, data sets, and MODFLOW input files; and viewing and evaluating MODFLOW output files. A key to success was

  14. Anglo-American views of Gavrilo Princip

    Directory of Open Access Journals (Sweden)

    Markovich Slobodan G.

    2015-01-01

    Full Text Available The paper deals with Western (Anglo-American views on the Sarajevo assassination/attentat and Gavrilo Princip. Articles on the assassination and Princip in two leading quality dailies (The Times and The New York Times have particularly been analysed as well as the views of leading historians and journalists who covered the subject including: R. G. D. Laffan, R. W. Seton-Watson, Winston Churchill, Sidney Fay, Bernadotte Schmitt, Rebecca West, A. J. P. Taylor, Vladimir Dedijer, Christopher Clark and Tim Butcher. In the West, the original general condemnation of the assassination and its main culprits was challenged when Rebecca West published her famous travelogue on Yugoslavia in 1941. Another Brit, the remarkable historian A. J. P. Taylor, had a much more positive view on the Sarajevo conspirators and blamed Germany and Austria-Hungary for the outbreak of the Great War. A turning point in Anglo-American perceptions was the publication of Vladimir Dedijer’s monumental book The Road to Sarajevo (1966, which humanised the main conspirators, a process initiated by R. West. Dedijer’s book was translated from English into all major Western languages and had an immediate impact on the understanding of the Sarajevo assassination. The rise of national antagonisms in Bosnia gradually alienated Princip from Bosnian Muslims and Croats, a process that began in the 1980s and was completed during the wars of the Yugoslav succession. Although all available sources clearly show that Princip, an ethnic Serb, gradually developed a broader Serbo-Croat and Yugoslav identity, he was ethnified and seen exclusively as a Serb by Bosnian Croats and Bosniaks and Western journalists in the 1990s. In the past century imagining Princip in Serbia and the West involved a whole spectrum of views. In interwar Anglo-American perceptions he was a fanatic and lunatic. He became humanised by Rebecca West (1941, A. J. P. Taylor showed understanding for his act (1956, he was fully

  15. EXACTRAC x-ray and beam isocenters--What's the difference?

    International Nuclear Information System (INIS)

    Tideman Arp, Dennis; Carl, Jesper

    2012-01-01

    Purpose: To evaluate the geometric accuracy of the isocenter of an image-guidance system, as implemented in the exactrac system from brainlab, relative to the linear accelerator radiation isocenter. Subsequently to correct the x-ray isocenter of the exactrac system for any geometric discrepancies between the two isocenters. Methods: Five Varian linear accelerators all equipped with electronic imaging devices and exactrac with robotics from brainlab were evaluated. A commercially available Winston-Lutz phantom and an in-house made adjustable base were used in the setup. The electronic portal imaging device of the linear accelerators was used to acquire MV-images at various gantry angles. Stereoscopic pairs of x-ray images were acquired using the exactrac system. The deviation between the position of the external laser isocenter and the exactrac isocenter was evaluated using the commercial software of the exactrac system. In-house produced software was used to analyze the MV-images and evaluate the deviation between the external laser isocenter and the radiation isocenter of the linear accelerator. Subsequently, the deviation between the radiation isocenter and the isocenter of the exactrac system was calculated. A new method of calibrating the isocenter of the exactrac system was applied to reduce the deviations between the radiation isocenter and the exactrac isocenter. Results: To evaluate the geometric accuracy a 3D deviation vector was calculated for each relative isocenter position. The 3D deviation between the external laser isocenter and the isocenter of the exactrac system varied from 0.21 to 0.42 mm. The 3D deviation between the external laser isocenter and the linac radiation isocenter ranged from 0.37 to 0.83 mm. The 3D deviation between the radiation isocenter and the isocenter of the exactrac system ranged from 0.31 to 1.07 mm. Using the new method of calibrating the exactrac isocenter the 3D deviation of one linac was reduced from 0.90 to 0.23 mm. The

  16. SU-F-T-640: Feasibility of Using a Commercially Available Surface Guided Radiotherapy System with An Open-Face SRS Immobilization System

    Energy Technology Data Exchange (ETDEWEB)

    Chinsky, B; Patel, R; Roeske, J; Surucu, M [Loyola University Medical Center, Maywood, IL (United States)

    2016-06-15

    Purpose: To evaluate the inherent accuracy of using a surface guided radiotherapy system (SGRT) in the setup and monitoring of patients receiving stereotactic radiosurgery with an open-face SRS immobilization system. Methods: An anthropomorphic head phantom was set up using the Qfix Encompass SRS Immobilization System on a Varian Edge with OSMS and Varian TrueBeam with AlignRT. The phantom was positioned at 0° gantry and couch. A reference image was acquired using the SGRT system and an ROI was created over the mask opening. The couch and gantry were rotated to different combinations focusing on clinically used SRS gantry/couch combinations and those blocking the SGRT cameras. Perceived surface deviation by the SGRT system from the reference image was recorded. A Winston-Lutz test was performed on couch angles tested and used to exclude couch walkout. The deviation magnitude was calculated using translational values and rotational raw values were recorded. Results: The maximum couch walkouts were: 0.4mm (Edge) and 0.5mm (TB). Solely rotating the gantry resulted in a median couch deviation of 0.2mm and range of 0.1–0.3mm for both linacs. Only rotating the couch (0° gantry) resulted in median deviations of 0.6mm and 0.5mm with ranges of 0.3–1.0mm and 0.3–0.7mm for the Edge and TB, respectively. Combining gantry and couch rotations, the median deviations were 0.7mm and 0.9mm with ranges of 0.3–1.1mm and 0.2–1.9mm for the Edge and TB, respectively. Including all combinations, rotation, roll, and pitch median deviations ranged from 0.1–0.3° with pitch demonstrating consistently higher values and a maximum deviation of 1.0° (both linacs). Conclusion: SGRT is a reliable monitoring tool, though taking into account system fluctuations, 1mm is too restrictive a site tolerance to use with the Qfix Encompass mask. Gantry rotation has little effect on system fluctuation even with camera blockage, whereas couch rotation has a larger effect.

  17. SU-F-T-640: Feasibility of Using a Commercially Available Surface Guided Radiotherapy System with An Open-Face SRS Immobilization System

    International Nuclear Information System (INIS)

    Chinsky, B; Patel, R; Roeske, J; Surucu, M

    2016-01-01

    Purpose: To evaluate the inherent accuracy of using a surface guided radiotherapy system (SGRT) in the setup and monitoring of patients receiving stereotactic radiosurgery with an open-face SRS immobilization system. Methods: An anthropomorphic head phantom was set up using the Qfix Encompass SRS Immobilization System on a Varian Edge with OSMS and Varian TrueBeam with AlignRT. The phantom was positioned at 0° gantry and couch. A reference image was acquired using the SGRT system and an ROI was created over the mask opening. The couch and gantry were rotated to different combinations focusing on clinically used SRS gantry/couch combinations and those blocking the SGRT cameras. Perceived surface deviation by the SGRT system from the reference image was recorded. A Winston-Lutz test was performed on couch angles tested and used to exclude couch walkout. The deviation magnitude was calculated using translational values and rotational raw values were recorded. Results: The maximum couch walkouts were: 0.4mm (Edge) and 0.5mm (TB). Solely rotating the gantry resulted in a median couch deviation of 0.2mm and range of 0.1–0.3mm for both linacs. Only rotating the couch (0° gantry) resulted in median deviations of 0.6mm and 0.5mm with ranges of 0.3–1.0mm and 0.3–0.7mm for the Edge and TB, respectively. Combining gantry and couch rotations, the median deviations were 0.7mm and 0.9mm with ranges of 0.3–1.1mm and 0.2–1.9mm for the Edge and TB, respectively. Including all combinations, rotation, roll, and pitch median deviations ranged from 0.1–0.3° with pitch demonstrating consistently higher values and a maximum deviation of 1.0° (both linacs). Conclusion: SGRT is a reliable monitoring tool, though taking into account system fluctuations, 1mm is too restrictive a site tolerance to use with the Qfix Encompass mask. Gantry rotation has little effect on system fluctuation even with camera blockage, whereas couch rotation has a larger effect.

  18. Evaluation of IsoCal geometric calibration system for Varian linacs equipped with on-board imager and electronic portal imaging device imaging systems.

    Science.gov (United States)

    Gao, Song; Du, Weiliang; Balter, Peter; Munro, Peter; Jeung, Andrew

    2014-05-08

    The purpose of this study is to evaluate the accuracy and reproducibility of the IsoCal geometric calibration system for kilovoltage (kV) and megavoltage (MV) imagers on Varian C-series linear accelerators (linacs). IsoCal calibration starts by imaging a phantom and collimator plate using MV images with different collimator angles, as well as MV and kV images at different gantry angles. The software then identifies objects on the collimator plate and in the phantom to determine the location of the treatment isocenter and its relation to the MV and kV imager centers. It calculates offsets between the positions of the imaging panels and the treatment isocenter as a function of gantry angle and writes a correction file that can be applied to MV and kV systems to correct for those offsets in the position of the panels. We performed IsoCal calibration three times on each of five Varian C-series linacs, each time with an independent setup. We then compared the IsoCal calibrations with a simplified Winston-Lutz (WL)-based system and with a Varian cubic phantom (VC)-based system. The maximum IsoCal corrections ranged from 0.7 mm to 1.5 mm for MV and 0.9 mm to 1.8 mm for kV imagers across the five linacs. The variations in the three calibrations for each linac were less than 0.2 mm. Without IsoCal correction, the WL results showed discrepancies between the treatment isocenter and the imager center of 0.9 mm to 1.6 mm (for the MV imager) and 0.5 mm to 1.1 mm (for the kV imager); with IsoCal corrections applied, the differences were reduced to 0.2 mm to 0.6 mm (MV) and 0.3 mm to 0.6 mm (kV) across the five linacs. The VC system was not as precise as the WL system, but showed similar results, with discrepancies of less than 1.0 mm when the IsoCal corrections were applied. We conclude that IsoCal is an accurate and consistent method for calibration and periodic quality assurance of MV and kV imaging systems.

  19. TH-AB-201-07: Filmless Treatment Localization QA for the CyberKnife System

    Energy Technology Data Exchange (ETDEWEB)

    Gersh, J [Gibbs Cancer Center & Research Institute - Pelham, Greer, SC (United States); Spectrum Medical Physics, LLC, Greenville, SC (United States); Noll, M [Accuray Incorporated, Sunnyvale, CA (United States)

    2016-06-15

    Purpose: Accuray recommends daily evaluation of the treatment localization and delivery systems (TLS/TDS) of the CyberKnife. The vendor-provided solution is a Winston-Lutz-type test that evaluates film shadows from an orthogonal beam pair (known as AQA). Since film-based techniques are inherently inefficient and potentially inconsistent and uncertain, this study explores a method which provides a comparable test with greater efficiency, consistency, and certainty. This test uses the QAStereoChecker (QASC, Standard Imaging, Inc., Middleton, WI), a high-resolution flat-panel detector with coupled fiducial markers for automated alignment. Fiducial tracking is used to achieve high translational and rotational position accuracy. Methods: A plan is generated delivering five circular beams, with varying orientation and angular incidence. Several numeric quantities are calculated for each beam: eccentricity, centroid location, area, major-axis length, minor-axis length, and orientation angle. Baseline values were acquired and repeatability of baselines analyzed. Next, errors were induced in the path calibration of the CK, and the test repeated. A correlative study was performed between the induced errors and quantities measured using the QASC. Based on vendor recommendations, this test should be able to detect a TLS/TDS offset of 0.5mm. Results: Centroid shifts correlated well with induced plane-perpendicular offsets (p < 0.01). Induced vertical shifts correlated best with the absolute average deviation of eccentricities (p < 0.05). The values of these metrics which correlated with the threshold of 0.5mm induced deviation were used as individual pass/fail criteria. These were then used to evaluate induced offsets which shifted the CK in all axes (a clinically-realistic offset), with a total offset of 0.5mm. This test provided high and specificity and sensitivity. Conclusion: From setup to analysis, this filmless TLS/TDS test requires 4 minutes, as opposed to 15–20

  20. SU-E-J-123: Targeting Accuracy of Image-Guided Radiosurgery for Intracranial Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Y; Wen, N; Zhao, B; Kim, J; Gordon, J; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

    2014-06-01

    Purpose: To evaluate the setup accuracies of image-guided intracranial radiosurgery across several different linear accelerator platforms. Methods: A CT scan with a slice thickness of 1.0 mm was acquired of a Rando head phantom (The Phantom Laboratory) in a U-frame mask (BrainLAB AG). The phantom had three embedded BBs, simulating a central, left, and anterior lesion. The phantom was setup with each BB placed at the radiation isocenter under image guidance. Four different setup procedures were investigated: (1) NTX-ExacTrac: 6 degree-of-freedom (6D) correction on a Novalis Tx (BrainLAB AG) with ExacTrac localization (BrainLAB AG); (2) NTX-CBCT: 4D correction on the Novalis Tx with cone-beam computed tomography (CBCT); (3) TrueBeam-CBCT: 4D correction on a TrueBeam (Varian) with CBCT; (4) Edge-CBCT: 6D correction on an Edge (Varian) with CBCT. The experiment was repeated 5 times with different initial setup error at each BB location on each platform, and the mean (μ) and one standard deviation (σ) of the residual error was compared.The congruence between radiation and imaging isocenters on each platform was evaluated by acquiring Winston Lutz (WL) images of a WL jig followed by imaging using ExacTrac or CBCT. The difference in coordinates of the jig relative to radiation and imaging isocenters was then recorded. Results: Averaged over all three BB locations, the residual vector setup errors (μ±σ) of the phantom in mm were 0.6±0.2, 1.0±0.5, 0.2±0.1, and 0.3±0.1 on NTX-ExacTrac, NTX-CBCT, TrueBeam-CBCT, and Edge-CBCT, with their ranges in mm being 0.4∼1.1, 0.4∼1.9, 0.1∼0.5, and 0.2∼0.6, respectively. And imaging isocenter was found stable relative to radiation isocenter, with the congruence to radiation isocenter in mm being 0.6±0.1, 0.7±0.1, 0.3±0.1, 0.2±0.1, respectively, on the four systems in the same order. Conclusion: Millimeter accuracy can be achieved with image-guided radiosurgery for intracranial lesions based on this set of experiments.

  1. SU-E-T-406: Use of TrueBeam Developer Mode and API to Increase the Efficiency and Accuracy of Commissioning Measurements for the Varian EDGE Stereotactic Linac

    International Nuclear Information System (INIS)

    Gardner, S; Gulam, M; Song, K; Li, H; Huang, Y; Zhao, B; Qin, Y; Snyder, K; Kim, J; Gordon, J; Chetty, I; Wen, N

    2014-01-01

    Purpose: The Varian EDGE machine is a new stereotactic platform, combining Calypso and VisionRT localization systems with a stereotactic linac. The system includes TrueBeam DeveloperMode, making possible the use of XML-scripting for automation of linac-related tasks. This study details the use of DeveloperMode to automate commissioning tasks for Varian EDGE, thereby improving efficiency and measurement consistency. Methods: XML-scripting was used for various commissioning tasks,including couch model verification,beam-scanning,and isocenter verification. For couch measurements, point measurements were acquired for several field sizes (2×2,4×4,10×10cm 2 ) at 42 gantry angles for two couch-models. Measurements were acquired with variations in couch position(rails in/out,couch shifted in each of motion axes) compared to treatment planning system(TPS)-calculated values,which were logged automatically through advanced planning interface(API) scripting functionality. For beam scanning, XML-scripts were used to create custom MLC-apertures. For isocenter verification, XML-scripts were used to automate various Winston-Lutz-type tests. Results: For couch measurements, the time required for each set of angles was approximately 9 minutes. Without scripting, each set required approximately 12 minutes. Automated measurements required only one physicist, while manual measurements required at least two physicists to handle linac positions/beams and data recording. MLC apertures were generated outside of the TPS,and with the .xml file format, double-checking without use of TPS/operator console was possible. Similar time efficiency gains were found for isocenter verification measurements Conclusion: The use of XML scripting in TrueBeam DeveloperMode allows for efficient and accurate data acquisition during commissioning. The efficiency improvement is most pronounced for iterative measurements, exemplified by the time savings for couch modeling measurements(approximately 10 hours

  2. Characterization of new hexagonal large area Geiger Avalanche Photodiodes

    International Nuclear Information System (INIS)

    Boccone, V.; Aguilar, J.A.; Della Volpe, D.; Christov, A.; Montaruli, T.; Rameez, M.; Basili, A.

    2013-06-01

    Photomultipliers (PMTs) are the standard detector for construction of the current generation of imaging Atmospheric Cherenkov Telescopes (IACTs). Despite impressive improvements in QE and reliability in the last years, these devices suffer from the limitation of being unable to operate in the partially illuminated sky (during full or partial moon periods) as the excess light leads to a significant increase in the rate of ageing of the devices themselves and consequently limit the life of the camera. A viable alternative is the large area Geiger-mode avalanche photodiodes (G-APDs also known as Silicon Photomultipliers or SiPMs) that are commercially available from different producers in various types and dimensions. The sufficiency of the maturity of this technology for application to Cherenkov Astronomy has already been demonstrated by the FACT telescope. One of the camera designs under study for the 4 m Davies Cotton Telescope foresees the utilization of a large area G-APDs coupled to non imaging light concentrators. In collaboration with Hamamatsu and deriving from their current technology, we have designed a new hexagonal shaped large area G-APD HEX S12516 which when coupled to a Winston cone of 24 degrees cutting angle allows for a pixel angular resolution of 0.25 degrees for a f/D 1.4 telescope with a diameter of 4 m. The device, available in 2 different cell size configurations (50 μm and 100 μm), is divided into 4 different channels powered in common cathode mode. A temperature sensor was included for a better temperature evaluation in the characterization phase. The first 3 prototypes were fully characterized and the results are compared to the larger area devices commercially available such as the S10985-050C (2x2 array of 3x3 mm 2 G-APDs). The photo-detection efficiency is measured applying the Poisson statistics method using pulsed LED at 7 different wavelengths from 355 to 670 nm and for different bias over-voltages (V ov ). Optical crosstalk and

  3. EXACTRAC x-ray and beam isocenters--What's the difference?

    Energy Technology Data Exchange (ETDEWEB)

    Tideman Arp, Dennis; Carl, Jesper [Department of Medical Physics, Oncology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9100 Aalborg (Denmark)

    2012-03-15

    Purpose: To evaluate the geometric accuracy of the isocenter of an image-guidance system, as implemented in the exactrac system from brainlab, relative to the linear accelerator radiation isocenter. Subsequently to correct the x-ray isocenter of the exactrac system for any geometric discrepancies between the two isocenters. Methods: Five Varian linear accelerators all equipped with electronic imaging devices and exactrac with robotics from brainlab were evaluated. A commercially available Winston-Lutz phantom and an in-house made adjustable base were used in the setup. The electronic portal imaging device of the linear accelerators was used to acquire MV-images at various gantry angles. Stereoscopic pairs of x-ray images were acquired using the exactrac system. The deviation between the position of the external laser isocenter and the exactrac isocenter was evaluated using the commercial software of the exactrac system. In-house produced software was used to analyze the MV-images and evaluate the deviation between the external laser isocenter and the radiation isocenter of the linear accelerator. Subsequently, the deviation between the radiation isocenter and the isocenter of the exactrac system was calculated. A new method of calibrating the isocenter of the exactrac system was applied to reduce the deviations between the radiation isocenter and the exactrac isocenter. Results: To evaluate the geometric accuracy a 3D deviation vector was calculated for each relative isocenter position. The 3D deviation between the external laser isocenter and the isocenter of the exactrac system varied from 0.21 to 0.42 mm. The 3D deviation between the external laser isocenter and the linac radiation isocenter ranged from 0.37 to 0.83 mm. The 3D deviation between the radiation isocenter and the isocenter of the exactrac system ranged from 0.31 to 1.07 mm. Using the new method of calibrating the exactrac isocenter the 3D deviation of one linac was reduced from 0.90 to 0.23 mm. The

  4. Role of isavuconazole in the treatment of invasive fungal infections

    Directory of Open Access Journals (Sweden)

    Wilson DT

    2016-08-01

    Full Text Available Dustin T Wilson,1,2 V Paul Dimondi,1,3 Steven W Johnson,1,4 Travis M Jones,1 Richard H Drew1,5 1Department of Pharmacy Practice, Campbell University College of Pharmacy & Health Sciences, Buies Creek, NC, USA; 2Department of Pharmacy, Duke University Hospital, Durham, NC, USA; 3Department of Pharmacy, Durham VA Medical Center, Durham, NC, USA; 4Department of Pharmacy, Forsyth Medical Center, Winston-Salem, NC, USA; 5Division of Infectious Diseases, Duke University Hospital, Durham, NC, USA Abstract: Despite recent advances in both diagnosis and prevention, the incidence of invasive fungal infections continues to rise. Available antifungal agents to treat invasive fungal infections include polyenes, triazoles, and echinocandins. Unfortunately, individual agents within each class may be limited by spectrum of activity, resistance, lack of oral formulations, significant adverse event profiles, substantial drug–drug interactions, and/or variable pharmacokinetic profiles. Isavuconazole, a second-generation triazole, was approved by the US Food and Drug Administration in March 2015 and the European Medicines Agency in July 2015 for the treatment of adults with invasive aspergillosis (IA or mucormycosis. Similar to amphotericin B and posaconazole, isavuconazole exhibits a broad spectrum of in vitro activity against yeasts, dimorphic fungi, and molds. Isavuconazole is available in both oral and intravenous formulations, exhibits a favorable safety profile (notably the absence of QTc prolongation, and reduced drug–drug interactions (relative to voriconazole. Phase 3 studies have evaluated the efficacy of isavuconazole in the management of IA, mucormycosis, and invasive candidiasis. Based on the results of these studies, isavuconazole appears to be a viable treatment option for patients with IA as well as those patients with mucormycosis who are not able to tolerate or fail amphotericin B or posaconazole therapy. In contrast, evidence of

  5. Advances in the management of erythropoietic protoporphyria – role of afamelanotide

    Directory of Open Access Journals (Sweden)

    Lane AM

    2016-12-01

    Full Text Available Ashley M Lane,1 Jerome T McKay,2 Herbert L Bonkovsky1 1Department of Internal Medicine, Section on Gastroenterology; 2Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract: Erythropoietic protoporphyria (EPP and the phenotypically similar disease X-linked protoporphyria (XLPP are inherited cutaneous porphyrias characterized clinically by acute non-blistering photosensitivity, intolerance to sunlight, and significantly reduced quality of life. They are due to marked overproduction of protoporphyrin (PP chiefly by erythroblasts and reticulocytes. In EPP, the underlying genetic defect is in the ferrochelatase gene, which encodes the final enzyme in the heme synthetic pathway. In XLPP, the genetic defect is a gain-of-function mutation, usually a four-base deletion, in the gene that encodes the enzyme 5-aminolevulinic acid synthase-2, the first and rate-controlling enzyme of heme synthesis in developing red blood cells. The excess PP causes acute and painful photosensitivity, being activated by light in the long ultraviolet to blue spectrum (380–420 nm, the Soret band. Although several treatments have been proposed, presently no very effective treatment exists for EPP or XLPP. Afamelanotide (Scenesse® is a first-in-class synthetic analog of α-melanocyte stimulating hormone. Afamelanotide mimics the naturally occurring hormone to increase skin pigmentation by increasing melanin production in melanocytes, resulting in increased sunlight tolerance in those with EPP/XLPP. Afamelanotide is currently approved for use in the European Union and Switzerland, and it is under review in the United States by the Food and Drug Administration for use in patients with EPP/XLPP. This paper provides a review of the clinical characteristics and current therapies for EPP/XLPP. We discuss the pharmacology, clinical efficacy, safety, and tolerability of afamelanotide and summarize the results of several

  6. Evaluating the Effect of a Web-Based E-Learning Tool for Health Professional Education on Clinical Vancomycin Use: Comparative Study.

    Science.gov (United States)

    Bond, Stuart Evan; Crowther, Shelley P; Adhikari, Suman; Chubaty, Adriana J; Yu, Ping; Borchard, Jay P; Boutlis, Craig Steven; Yeo, Wilfred Winston; Miyakis, Spiros

    2018-02-26

    improved scores among doctors. This implies that different strategies may be required for optimizing the effectiveness of education among different health professional groups. Low survey response rates limited conclusions regarding the tool's effectiveness. Improvements to design and evaluation methodology may increase the likelihood of a demonstrable effect from e-learning tools in the future. ©Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis. Originally published in JMIR Medical Education (http://mededu.jmir.org), 26.02.2018.

  7. Verification of the linac isocenter for stereotactic radiosurgery using cine-EPID imaging and arc delivery

    Energy Technology Data Exchange (ETDEWEB)

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O' Connor, Daryl J.; Greer, Peter B. [School of Mathematical and Physical Sciences, University of Newcastle, Newcastle, New South Wales 2308 (Australia); Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales 2310, Australia and School of Mathematical and Physical Sciences, University of Newcastle, Newcastle, New South Wales 2308 (Australia)

    2011-07-15

    Purpose:Verification of the mechanical isocenter position is required as part of comprehensive quality assurance programs for stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments. Several techniques have been proposed for this purpose but each of them has certain drawbacks. In this paper, a new efficient and more comprehensive method using cine-EPID images has been introduced for automatic verification of the isocenter with sufficient accuracy for stereotactic applications. Methods: Using a circular collimator fixed to the gantry head to define the field, EPID images of a Winston-Lutz phantom were acquired in cine-imaging mode during 360 deg. gantry rotations. A robust matlab code was developed to analyze the data by finding the center of the field and the center of the ball bearing shadow in each image with sub-pixel accuracy. The distance between these two centers was determined for every image. The method was evaluated by comparison to results of a mechanical pointer and also by detection of a manual shift applied to the phantom position. The repeatability and reproducibility of the method were tested and it was also applied to detect couch and collimator wobble during rotation. Results:The accuracy of the algorithm was 0.03 {+-} 0.02 mm. The repeatability was less than 3 {mu}m and the reproducibility was less than 86 {mu}m. The time elapsed for the analysis of more than 100 cine images of Varian aS1000 and aS500 EPIDs were {approx}65 and 20 s, respectively. Processing of images taken in integrated mode took 0.1 s. The output of the analysis software is printable and shows the isocenter shifts as a function of angle in both in-plane and cross-plane directions. It gives warning messages where the shifts exceed the criteria for SRS/SRT and provides useful data for the necessary adjustments in the system including bearing system and/or room lasers. Conclusions: The comprehensive method introduced in this study uses cine-images, is highly accurate, fast, and

  8. An Investigation of Faculty Relationships as a Source of Motivation for STEM Undergraduates at a Historically Black University

    Science.gov (United States)

    Mitchell, Aquila

    2011-12-01

    The expansion of STEM education and career opportunities among underrepresented populations is a national priority. Therefore, more research is needed that examines the institutional, instructional and individual factors related to African American students' success in these fields. This dissertation study was drawn from a larger mixed-methods longitudinal study (Freeman and Winston, 2007). It utilized a concurrent embedded design of mixed methods (Creswell, 2009), to investigate faculty relationships as a source of motivation for STEM undergraduates at a HBCU. Bandura's (1986) social cognitive theory was the theoretical basis for this study. The following research questions were examined: (a) What is the nature of student-faculty relationships among STEM undergraduates attending an HBCU; (b) How does the nature of faculty student relationships vary by gender and STEM major; (c) How do student-faculty relationships influence students' persistence in STEM, self-concept of ability in mathematics and in science and grade point average; and (d) Does the influence of student-faculty relationships on self-concept of ability in mathematics and in science and grade point average vary by gender and STEM major? Freshman college students (N=167) who had a declared major in STEM fall 2009 were participants in this study. Students were predominately Black/African American (82%) and predominately female (71%). The Student-Professor Interaction Scale (SPIS) was used to measure various dimensions of student-faculty interactions (Cokley, Komarraju, Rosales, et al., 2006). The Experiences with Faculty Scale (Pace & Kuh, 1998) was used to measure the frequency of student's experiences with faculty. Self-Concept of Ability Scales in Mathematics and in Science (Marsh, 1999) was used to measure students' global perception of their abilities. An open-ended question was designed to expand and provide breadth to the quantitative results. Findings indicated that student

  9. TH-AB-201-07: Filmless Treatment Localization QA for the CyberKnife System

    International Nuclear Information System (INIS)

    Gersh, J; Noll, M

    2016-01-01

    Purpose: Accuray recommends daily evaluation of the treatment localization and delivery systems (TLS/TDS) of the CyberKnife. The vendor-provided solution is a Winston-Lutz-type test that evaluates film shadows from an orthogonal beam pair (known as AQA). Since film-based techniques are inherently inefficient and potentially inconsistent and uncertain, this study explores a method which provides a comparable test with greater efficiency, consistency, and certainty. This test uses the QAStereoChecker (QASC, Standard Imaging, Inc., Middleton, WI), a high-resolution flat-panel detector with coupled fiducial markers for automated alignment. Fiducial tracking is used to achieve high translational and rotational position accuracy. Methods: A plan is generated delivering five circular beams, with varying orientation and angular incidence. Several numeric quantities are calculated for each beam: eccentricity, centroid location, area, major-axis length, minor-axis length, and orientation angle. Baseline values were acquired and repeatability of baselines analyzed. Next, errors were induced in the path calibration of the CK, and the test repeated. A correlative study was performed between the induced errors and quantities measured using the QASC. Based on vendor recommendations, this test should be able to detect a TLS/TDS offset of 0.5mm. Results: Centroid shifts correlated well with induced plane-perpendicular offsets (p < 0.01). Induced vertical shifts correlated best with the absolute average deviation of eccentricities (p < 0.05). The values of these metrics which correlated with the threshold of 0.5mm induced deviation were used as individual pass/fail criteria. These were then used to evaluate induced offsets which shifted the CK in all axes (a clinically-realistic offset), with a total offset of 0.5mm. This test provided high and specificity and sensitivity. Conclusion: From setup to analysis, this filmless TLS/TDS test requires 4 minutes, as opposed to 15–20

  10. SU-F-J-177: A Novel Image Analysis Technique (center Pixel Method) to Quantify End-To-End Tests

    Energy Technology Data Exchange (ETDEWEB)

    Wen, N; Chetty, I [Henry Ford Health System, Detroit, MI (United States); Snyder, K [Henry Ford Hospital System, Detroit, MI (United States); Scheib, S [Varian Medical System, Barton (Switzerland); Qin, Y; Li, H [Henry Ford Health System, Detroit, Michigan (United States)

    2016-06-15

    Purpose: To implement a novel image analysis technique, “center pixel method”, to quantify end-to-end tests accuracy of a frameless, image guided stereotactic radiosurgery system. Methods: The localization accuracy was determined by delivering radiation to an end-to-end prototype phantom. The phantom was scanned with 0.8 mm slice thickness. The treatment isocenter was placed at the center of the phantom. In the treatment room, CBCT images of the phantom (kVp=77, mAs=1022, slice thickness 1 mm) were acquired to register to the reference CT images. 6D couch correction were applied based on the registration results. Electronic Portal Imaging Device (EPID)-based Winston Lutz (WL) tests were performed to quantify the errors of the targeting accuracy of the system at 15 combinations of gantry, collimator and couch positions. The images were analyzed using two different methods. a) The classic method. The deviation was calculated by measuring the radial distance between the center of the central BB and the full width at half maximum of the radiation field. b) The center pixel method. Since the imager projection offset from the treatment isocenter was known from the IsoCal calibration, the deviation was determined between the center of the BB and the central pixel of the imager panel. Results: Using the automatic registration method to localize the phantom and the classic method of measuring the deviation of the BB center, the mean and standard deviation of the radial distance was 0.44 ± 0.25, 0.47 ± 0.26, and 0.43 ± 0.13 mm for the jaw, MLC and cone defined field sizes respectively. When the center pixel method was used, the mean and standard deviation was 0.32 ± 0.18, 0.32 ± 0.17, and 0.32 ± 0.19 mm respectively. Conclusion: Our results demonstrated that the center pixel method accurately analyzes the WL images to evaluate the targeting accuracy of the radiosurgery system. The work was supported by a Research Scholar Grant, RSG-15-137-01-CCE from the American

  11. Multi-stage origin of the Coast Range ophiolite, California: Implications for the life cycle of supra-subduction zone ophiolites

    Science.gov (United States)

    Shervais, J.W.; Kimbrough, D.L.; Renne, P.; Hanan, B.B.; Murchey, B.; Snow, C.A.; Zoglman, Schuman M.M.; Beaman, J.

    2004-01-01

    dikes) to represent the collision of an active spreading ridge. Subsequent reorganization of relative plate motions led to sinistral transpression, along with renewed subduction and accretion of the Franciscan Complex. The latter event resulted in uplift and exhumation of the ophiolite by the process of accretionary uplift. ?? 2004 by V. H. Winston and Son, Inc. All rights reserved.

  12. PREFACE: XXXIII Symposium on Nuclear Physics

    Science.gov (United States)

    Barrón-Palos, Libertad; Bijker, Roelof; Fossion, Ruben; Lizcano, David

    2010-04-01

    physics, ranging from the traditional fields of nuclear structure and reactions to radioactive beams, nuclear astrophysics, hadronic physics, fundamental symmetries, ultrarelativistic heavy ions, cosmic rays and quantum chaos. The high quality of the talks, the prestige of the speakers and the broad spectrum of subjects covered in the meeting, shows that nuclear physics is a very active area at the frontier of scientific research which establishes bridges between many different disciplines. One of the exciting new areas in nuclear physics is that of radioactive beams. It provides a powerful tool not only to study exotic nuclei close to the proton and neutron drip lines to obtain important information about the nature of the nucleon-nucleon interaction in stable and unstable nuclei, but also to address questions of fundamental importance in nuclear astrophysics as well as in various applications like mass spectroscopy, the production of radioactive isotopes and medical applications (Galindo-Uribarri). There was a presentation on the FRIB project which is currently under construction in the USA and its relevance for nuclear astrophysics and the limits of stability (Sherrill and Schatz) In the session on nuclear structure, there were several talks on the nucleon-nucleon interaction in nuclei close to the proton and neutron drip lines, like neutron-proton pairing in nuclei with an equal number of protons and neutrons (Pittel), and studies of stable and unstable neutron-rich nuclei near the closed shells N = 82 and N = 50 using (d, p) transfer reactions and Coulomb excitation by means of radioactive beams (Cizewski and Padilla-Rodal). There were several talks on the importance of reaction rates for the excitation of spin-isospin resonances (Sakai), massive star evolution (Klapp) and nuclear synthesis and stellar evolution (Rolfs). In another presentation, the importance of rare isotopes for astrophysical processes was highlighted (Schatz). In addition, there were discussions

  13. Integration of the digital technologies in the teaching of astronomy

    Science.gov (United States)

    de Macedo, J. A.; Voelzke, M. R.

    2014-08-01

    has researched little or no knowledge of astronomy-related topics, which can be explained by the exclusion of astronomy in basic education in Brazil; (iii) the analysis of the final questionnaire showed that there was significant learning (Ausubel; Novak and Hanesian, 1978), since the results indicate a significant improvement in student responses, (iv) the results indicate a high level of student satisfaction, and; (v) viability of resource use involving digital technologies in the teaching of astronomy, which may contribute to the broadening of methodological options of future teachers and meet their training needs. When the study of sciences takes place without interaction with natural and technological phenomena, a huge gap in the education of students occurs. In this sense, the use of different resources such as models, observations, real and virtual experiments, animations, simulations, video classes, can arouse students' interest in the conceptual content, different from what occurs when the study permits only using conventional resources, as books and handouts. D.P. Ausubel; J.D. Novak; H. Hanesian. Educational psychology: a cognitive view. 2nd. ed. New York: Holt, Rinehart and Winston, 1978. 733p. M. R. Voelzke; E. P. Gonzaga. Analysis of the astronomical concepts presented by teachers of some brazilian state schools. Journal of Science Education, v. 14, n.1, 23-25, 2013.

  14. SU-C-BRB-04: Characteristics and Performance Evaluation of the First Commercial MLC for a Robotic Delivery System

    Energy Technology Data Exchange (ETDEWEB)

    Fuerweger, C [Erasmus MC Cancer Institute, Rotterdam (Netherlands); European Cyberknife Center Munich, Munich, DE (Germany); Prins, P; Coskan, H; Heijmen, B [Erasmus MC Cancer Institute, Rotterdam (Netherlands)

    2015-06-15

    Purpose: To assess characteristics and performance of the “Incise™” MLC (41 leaf pairs, 2.5mm width, FFF linac) mounted on the robotic SRS/SBRT platform “CyberKnife M6™” in a pre-clinical 5 months (11/2014–03/2015) test period. Methods: Beam properties were measured with unshielded diodes and EBT3 film. The CyberKnife workspace for MLC was analyzed by transforming robot node coordinates (cranial / body paths) into Euler geometry. Bayouth tests for leaf / bank position accuracy were performed in standard (A/P) and clinically relevant non-standard positions, before and after exercising the MLC for 10+ minutes. Total system and delivery accuracy were assessed in End-to-End tests and dosimetric verification of exemplary plans. Stability over time was evaluated in Picket-Fence-and adapted Winston-Lutz-tests (AQA) for different collimator angles. Results: Penumbrae (80–20%, with 100%=2*dose at inflection point; SAD 80cm; 10cm depth) parallel / perpendicular to leaf motion were 2.87/2.64mm for the smallest (0×76×0.75cm{sup 2}) and 5.34/4.94mm for the largest (9.76×9.75cm{sup 2}) square field. MLC circular field penumbrae exceeded fixed cones by 10–20% (e.g. 60mm: 4.0 vs. 3.6mm; 20mm: 3.6 vs. 2.9mm). Interleaf leakage was <0.5%. Clinically accessible workspace with MLC covered (non-coplanar) gantry angles of [-113°;+112°] (cranial) and [-108°;+102°] (body), and collimator angles of [-100°;+107°] (cranial) and [-91°;+100°] (body). Average leaf position offsets were ≤0.2mm in 14 standard A/P Bayouth tests and ≤0.6mm in 8 non-standard direction tests. Pre-test MLC exercise increased jaggedness (range ±0.3mm vs. ±0.5mm) and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.39±0.06mm in 6 End-to-End tests. Picket-Fence and AQA showed no adverse trends during the test period. Conclusion: The Incise™ MLC for CyberKnife M6™ displayed high accuracy and mechanical stability over the test period. The

  15. SU-F-T-647: Linac-Based Stereotactic Radiosurgery (SRS) in the Treatment of Trigeminal Neuralgia: Detailed Description of SRS Procedural Technique and Reported Clinical Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Pokhrel, D; Sood, S; Badkul, R; Jiang, H; Stepp, T; Camarata, P; Wang, F [University of Kansas Hospital, Kansas City, KS (United States)

    2016-06-15

    Purpose: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. Methods: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009–2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study. Experienced neurosurgeon and radiation oncologist delineated the TNR on 1.0mm thin 3D-FIESTA-MRI that was co-registered with 0.7mm thin planning-CT. Treatment plans were generated in iPlan (BrainLAB) with a 4-mm diameter cone using 79 arcs with differential-weighting for Novalis-TX 6MV-SRS(1000MU/min) beam and optimized to minimize brainstem dose. Winston-Lutz test was performed before each treatment delivery with sub-millimeter isocenter accuracy. Quality assurance of frame placement was maintained by helmet-bobble-measurement before simulation-CT and before patient setup at treatment couch. OBI-CBCT scan was performed for patient setup verification without applying shifts. On clinical follow up, treatment response was assessed using Barrow Neurological Institute Pain Intensity Score(BNI-score:I–V). Results: 26/28 TNR-patients (16-males/10-females) who were treated with following single-fraction point-dose to isocenter: 80Gy(n=22),75Gy(n=1),70Gy(n=2) and 60Gy(n=1, re-treatment) were followed up. Median follow-up interval was 8.5-months (ranged:1–48.5months). Median age was 70-yr (ranged:43–93-yr). Right/left TNR ratio was 15/11. Delivered total # of average MUs was 19034±1204. Average beam-on-time: 19.0±1.3min. Brainstem max-dose and dose to 0.5cc were 13.3±2.4Gy (ranged:8.1–16.5Gy) and 3.6±0.4Gy (ranged:3.0–4.9Gy). On average, max-dose to optic-apparatus was ≤1.2Gy. Mean value of max-dose to eyes/lens was 0.26Gy/0.11Gy

  16. Ocular manifestations of idiopathic aplastic anemia: retrospective study and literature review

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2014-04-01

    Full Text Available Ahmad M Mansour,1 Jong Wook Lee,2 Seung Ah Yahng,2 Kyu Seop Kim,3 Maha Shahin,4 Nelson Hamerschlak,5 Rubens N Belfort,6 Shree K Kurup71Department of Ophthalmology, American University of Beirut, Rafic Hariri University Hospital, Beirut, Lebanon; 2Division of Hematology, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea; 3Department of Ophthalmology, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea; 4Department of Ophthalmology, Mansoura University, Mansoura City, Egypt; 5Oncology and Hematology Program, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil; 6Vision Institute, Hospital São Paulo, Federal University of São Paulo, Brazil; 7Department of Ophthalmology, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USAAbstract: Aplastic anemia (AA is a rare disease with few reports on its ophthalmic ­manifestations. The ocular findings are described in a retrospective consecutive series of 719 AA Korean patients followed at the Hematology Clinic of The Catholic University of Korea. Out of a total of 719 patients, 269 patients had eye examinations, 156 patients had retinal evaluation, and 37 (23.7% had retinal findings. These 37 patients had unilateral retinal ­hemorrhage in seven and bilateral retinal hemorrhage in 30 with mean hemoglobin of 6.6 g/dL (range 2.7–12.6 g/dL and platelet counts of 18.8×109/L (range 4–157×109/L; central retinal vein occlusion-like picture occurred in nine patients and these had similar rheology to the rest of the subjects; optic disc edema, cotton-wool spots, macular edema, and dry eyes occurred in two, three, five, and three patients, respectively. In this Korean series of 141 subjects with AA, systemic bleeding occurred in 24.8% of subjects, retinal hemorrhage in 37% of subjects, and any bleeding site (eye or elsewhere occurred in 47.5% of subjects with AA. A

  17. Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors

    Directory of Open Access Journals (Sweden)

    Rossmeisl JH

    2017-04-01

    Full Text Available John H Rossmeisl,1–3 Kelli Hall-Manning,4 John L Robertson,1,3,5 Jamie N King,1,2 Rafael V Davalos,3,5 Waldemar Debinski,3 Subbiah Elankumaran6,† 1Veterinary and Comparative Neuro-Oncology Laboratory, 2Department of Small Animal Clinical Sciences, 3The Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, NC, 4Virginia Tech Animal Laboratory Services, Virginia-Maryland College of Veterinary Medicine, 5Department of Biomedical Engineering and Mechanics, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Virginia Tech, 6Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA†The authors regret to advise of the passing of Dr Subbiah Elankumaran prior to publicationBackground: The expression of the urokinase plasminogen activator receptor (uPAR, a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA, have been associated with the invasive and metastatic potentials of a variety of human brain tumors through their regulation of extracellular matrix degradation. Domesticated dogs develop naturally occurring brain tumors that share many clinical, phenotypic, molecular, and genetic features with their human counterparts, which has prompted the use of the dogs with spontaneous brain tumors as models to expedite the translation of novel brain tumor therapeutics to humans. There is currently little known regarding the role of the uPA system in canine brain tumorigenesis. The objective of this study was to characterize the expression of uPAR and the activity of uPA in canine brain tumors as justification for the development of uPAR-targeted brain tumor therapeutics in dogs.Methods: We investigated the expression of uPAR in 37 primary canine brain tumors using immunohistochemistry, Western blotting, real

  18. A long-term, open-label safety study of single-entity hydrocodone bitartrate extended release for the treatment of moderate to severe chronic pain

    Directory of Open Access Journals (Sweden)

    Nalamachu S

    2014-11-01

    Full Text Available Srinivas Nalamachu,1,2 Richard L Rauck,3 Martin E Hale,4 Orlando G Florete Jr,5 Cynthia Y Robinson,6 Stephen J Farr,6 1International Clinical Research Institute, Overland Park, KS, USA; 2Kansas University Medical Center, Kansas City, KS, USA; 3Carolinas Pain Institute, Center for Clinical Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 4Gold Coast Research, LLC, Weston, FL, USA; 5Institute of Pain Management, Jacksonville, FL, USA; 6Zogenix, Inc., Emeryville, CA, USA Objective: To evaluate the long-term safety, tolerability, and effectiveness of single-entity extended-release hydrocodone in opioid-experienced subjects with moderate to severe chronic pain not receiving adequate pain relief or experiencing intolerable side effects from their current opioid. Methods: This multicenter, open-label study started with a conversion/titration phase (≤6 weeks where subjects (n=638 were converted to individualized doses (range 20–300 mg of extended-release hydrocodone dosed every 12 hours, followed by a 48-week maintenance phase (n=424. The primary objective (safety and tolerability and the secondary objective (long-term efficacy as measured by change in average pain score; 0= no pain, 10= worst imaginable pain were monitored throughout the study. Results: Subjects were treated for a range of chronic pain etiologies, including osteoarthritis, low back pain, and neuropathic and musculoskeletal conditions. The mean hydrocodone equivalent dose at screening was 68.9±62.2 mg/day and increased to 139.5±81.7 mg/day at the start of the maintenance phase. Unlimited dose adjustments were permitted at the investigator's discretion during the maintenance phase, reflecting typical clinical practice. No unexpected safety issues were reported. Common adverse events during the conversion/titration and maintenance phases, respectively, were constipation (11.3% and 12.5%, nausea (10.7% and 9.9%, vomiting (4.1% and 9.7%, and somnolence (7

  19. airGRteaching: an R-package designed for teaching hydrology with lumped hydrological models

    Science.gov (United States)

    Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Andréassian, Vazken; Brigode, Pierre

    2017-04-01

    discharges, which are updated immediately (a calibration only needs a couple of seconds or less, a simulation is almost immediate). In addition, time series of internal variables, live-visualisation of internal variables evolution and performance statistics are provided. This interface allows for hands-on exercises that can include for instance the analysis by students of: - The effects of each parameter and model components on simulated discharge - The effects of objective functions based on high flows- or low flows-focused criteria on simulated discharge - The seasonality of the model components. References Winston Chang, Joe Cheng, JJ Allaire, Yihui Xie and Jonathan McPherson (2016). shiny: Web Application Framework for R. R package version 0.13.2. https://CRAN.R-project.org/package=shiny Coron L., Thirel G., Perrin C., Delaigue O., Andréassian V., airGR: a suite of lumped hydrological models in an R-package, Environmental Modelling and software, 2017, submitted. Coron, L., Perrin, C. and Michel, C. (2016). airGR: Suite of GR hydrological models for precipitation-runoff modelling. R package version 1.0.3. https://webgr.irstea.fr/airGR/?lang=en. Olivier Delaigue and Laurent Coron (2016). airGRteaching: Tools to simplify the use of the airGR hydrological package by students. R package version 0.0.1. https://webgr.irstea.fr/airGR/?lang=en R Core Team (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.

  20. SU-C-BRB-04: Characteristics and Performance Evaluation of the First Commercial MLC for a Robotic Delivery System

    International Nuclear Information System (INIS)

    Fuerweger, C; Prins, P; Coskan, H; Heijmen, B

    2015-01-01

    Purpose: To assess characteristics and performance of the “Incise™” MLC (41 leaf pairs, 2.5mm width, FFF linac) mounted on the robotic SRS/SBRT platform “CyberKnife M6™” in a pre-clinical 5 months (11/2014–03/2015) test period. Methods: Beam properties were measured with unshielded diodes and EBT3 film. The CyberKnife workspace for MLC was analyzed by transforming robot node coordinates (cranial / body paths) into Euler geometry. Bayouth tests for leaf / bank position accuracy were performed in standard (A/P) and clinically relevant non-standard positions, before and after exercising the MLC for 10+ minutes. Total system and delivery accuracy were assessed in End-to-End tests and dosimetric verification of exemplary plans. Stability over time was evaluated in Picket-Fence-and adapted Winston-Lutz-tests (AQA) for different collimator angles. Results: Penumbrae (80–20%, with 100%=2*dose at inflection point; SAD 80cm; 10cm depth) parallel / perpendicular to leaf motion were 2.87/2.64mm for the smallest (0×76×0.75cm 2 ) and 5.34/4.94mm for the largest (9.76×9.75cm 2 ) square field. MLC circular field penumbrae exceeded fixed cones by 10–20% (e.g. 60mm: 4.0 vs. 3.6mm; 20mm: 3.6 vs. 2.9mm). Interleaf leakage was <0.5%. Clinically accessible workspace with MLC covered (non-coplanar) gantry angles of [-113°;+112°] (cranial) and [-108°;+102°] (body), and collimator angles of [-100°;+107°] (cranial) and [-91°;+100°] (body). Average leaf position offsets were ≤0.2mm in 14 standard A/P Bayouth tests and ≤0.6mm in 8 non-standard direction tests. Pre-test MLC exercise increased jaggedness (range ±0.3mm vs. ±0.5mm) and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.39±0.06mm in 6 End-to-End tests. Picket-Fence and AQA showed no adverse trends during the test period. Conclusion: The Incise™ MLC for CyberKnife M6™ displayed high accuracy and mechanical stability over the test period. The specific Cyber

  1. Test of variables of attention (TOVA as a predictor of early attention complaints, an antecedent to dementia

    Directory of Open Access Journals (Sweden)

    Eric R Braverman

    2010-10-01

    Full Text Available Eric R Braverman1,5, Amanda Lih-Chuan Chen2, Thomas JH Chen3, John D Schoolfield4, Alison Notaro5, Dasha Braverman5, Mallory Kerner5, Seth H Blum6 , Vanessa Arcuri5, Michael Varshavskiy5, Uma Damle5 , B William Downs7, Roger L Waite7, Marlene Oscar-Berman8, John Giordano9 , Kenneth Blum5,6,7,101Division of Neurological Surgery, Weill Cornell College of Medicine, New York, NY, USA; 2Department of Engineering and Management of Advanced Technology, 3Department of Occupational Safety and Health, Chang Jung Christian University, Tainan, Taiwan Republic of China; 4Department of Periodontics, University of Texas, Health Science Center, San Antonio, TX, USA; 5PATH Research Foundation, New York, NY, USA; 6Department of Nutritional Genomics, Synaptamine, Inc., San Antonio, TX, USA; 7Department of Personalized Medicine, LifeGen, Inc., La Jolla, CA, USA; 8Boston University School of Medicine, Boston VA, Boston, MA, USA; 9Department of Holistic Medicine, G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA; 10Department of Physiology and Pharmacology, University of Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USAAbstract: The goal of this study was to determine if impairments detected by the test of variables of attention (TOVA may be used to predict early attention complaints and memory impairments accurately in a clinical setting. We performed a statistical analysis of outcomes in a patient population screened for attention deficit hyperactivity disorder or attention complaints, processing errors as measured by TOVA and the Wechsler Memory Scale (WMS-III results. Attention deficit disorder (ADD checklists, constructed using the Diagnostic and Statistical Manual of Mental Disorders 4th Edition criteria, which were completed by patients at PATH Medical, revealed that 72.8% of the patients had more than one attention complaint out of a total of 16 complaints, and 41.5% had more than five complaints. For the 128

  2. Waste is a Terrible Thing to Mind: Perspectives on the Cleanup of the United States Nuclear Weapons Complex

    Science.gov (United States)

    Bodde, David

    1997-03-01

    Symposium will address this cleanup from the perspective of contemporary issues, rather than the mistakes of the past. Dr. David Bodde, currently Co-Chair of the Environmental Management Advisory Board, which advises the DoE on technical and policy issues pertaining to the cleanup, will chair the Symposium. Dr. Frank Parker, Distinguished Professor of Environmental and Water Resources Engineering at Vanderbilt University, will provide a general description of these problems and issues, including cultural and historical factors, a technical description of the wastes, and what is physically required for resolution. The Honorable Alvin Alm, Assistant Secretary of Energy for Environmental Management, will describe the current strategy for solving the problem, how this differs from approaches used in the past, what can realistically be accomplished and when and at what cost. Mr. Thomas Winston of the Ohio Environmental Protection Agency, will present the perspective of the affected localities. And Dr. Charles Powers, Executive Director of the Environmental and Occupational Health Sciences Institute, will speak to the current role and future prospects for risk analysis in improving the allocation of resources for cleanup.

  3. Construct validity of patient-reported outcome instruments in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Batt K

    2017-08-01

    Full Text Available Katharine Batt,1 Michael Recht,2 David L Cooper,3 Neeraj N Iyer,3 Christine L Kempton4 1Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, 2The Hemophilia Center, Oregon Health & Science University, Portland, OR, 3Novo Nordisk Inc., Plainsboro, NJ, 4Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA Background: People with hemophilia (PWH experience frequent joint bleeding, resulting in pain and functional impairment. Generic and disease-specific patient-reported outcome (PRO instruments have been used in clinical studies, but rarely in the comprehensive hemophilia care setting. Objective: The objective of this study was to assess construct validity of PRO instruments measuring pain, functional impairment, and health-related quality of life in US PWH with a history of joint pain/bleeding. Methods: Adult male PWH completed 4 PRO instruments (EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], SF-36v2, Hemophilia Activities List [HAL] and underwent a musculoskeletal examination (Hemophilia Joint Health Score v2.1 [HJHS]. Construct validity between index and domain scores was evaluated by Pearson product-moment correlation coefficient. Results: A total of 381 PWH were enrolled. EQ-5D-5L Mobility correlated with BPI, SF-36v2, and HAL domains related to pain, physical function, and activity of the lower extremities. EQ-5D-5L Self-Care correlated only with HAL Self-Care. EQ-5D-5L Usual Activities correlated with BPI Pain Interference and domains within SF-36v2 and HAL related to pain and physical function/activities (particularly those involving the lower extremities. EQ-5D-5L Pain/Discomfort correlated with Bodily Pain and Physical Summary on SF-36v2, HAL Overall Activity, and all BPI pain domains. EQ-5D-5L Anxiety/Depression correlated with social/emotional/mental aspects of SF-36v2. On BPI, most pain domains correlated with Bodily

  4. Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Tetteh PW

    2013-06-01

    Full Text Available Paul Winston Tetteh,1,4 Charles Antwi-Boasiako,1 Ben Gyan,3 Daniel Antwi,1 Festus Adzaku,1 Kwame Adu-Bonsaffoh,1,2 Samuel Obed21Department of Physiology, 2Department of Obstetrics and Gynecology, University of Ghana Medical School, Accra, Ghana; 3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana; 4Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, Utrecht, The NetherlandsBackground: The cause of pre-eclampsia remains largely unknown, but oxidative stress (an imbalance favoring oxidant over antioxidant forces has been implicated in contributing to the clinical symptoms of hypertension and proteinuria. Assessment of oxidative stress in pre-eclampsia using urinary isoprostane has produced conflicting results, and it is likely that renal function may affect isoprostane excretion. The aim of this study was to determine the role of oxidative stress in the pathophysiology of pre-eclampsia and to assess the effect of renal function on isoprostane excretion in pre-eclampsia in the Ghanaian population.Methods: This was a case-controlled study, comprising 103 pre-eclamptic women and 107 normal pregnant controls and conducted at the Korle-Bu Teaching Hospital between December 2006 and May 2007. The study participants were enrolled in the study after meeting the inclusion criteria and signing their written informed consent. Oxidative stress was determined by measuring urinary excretion of isoprostane and total antioxidant capacity using an enzyme-linked immunosorbent assay technique. Renal function was assessed by calculating the estimated glomerular filtration rate using the Modification of Diet in Renal Disease formula.Results: The pre-eclampsia group had significantly (P = 0.0006 higher urinary isoprostane excretion (2.81 ± 0.14 ng/mg creatinine than the control group (2.01 ± 0.18 ng/mg creatinine and a significantly (P = 0.0008 lower total antioxidant power (1

  5. The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy

    Directory of Open Access Journals (Sweden)

    Kast RE

    2017-07-01

    Full Text Available Richard E Kast,1 Nicolas Skuli,2 Samuel Cos,3 Georg Karpel-Massler,4 Yusuke Shiozawa,5 Ran Goshen,6 Marc-Eric Halatsch4 1IIAIGC Study Center, Burlington, VT, USA; 2INSERM, Centre de Recherches en Cancérologie de Toulouse – CRCT, UMR1037 Inserm/Université Toulouse III – Paul Sabatier, Toulouse, France; 3Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Valdecilla Research Institute (IDIVAL, Santander, Spain; 4Department of Neurosurgery, Ulm University Hospital, Ulm, Germany; 5Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA; 6Eliaso Consulting Ltd., Tel Aviv-Yafo, Israel Abstract: Breast cancer metastatic to bone has a poor prognosis despite recent advances in our understanding of the biology of both bone and breast cancer. This article presents a new approach, the ABC7 regimen (Adjuvant for Breast Cancer treatment using seven repurposed drugs, to metastatic breast cancer. ABC7 aims to defeat aspects of epithelial-to-mesenchymal transition (EMT that lead to dissemination of breast cancer to bone. As add-on to current standard treatment with capecitabine, ABC7 uses ancillary attributes of seven already-marketed noncancer treatment drugs to stop both the natural EMT process inherent to breast cancer and the added EMT occurring as a response to current treatment modalities. Chemotherapy, radiation, and surgery provoke EMT in cancer generally and in breast cancer specifically. ABC7 uses standard doses of capecitabine as used in treating breast cancer today. In addition, ABC7 uses 1 an older psychiatric drug, quetiapine, to block RANK signaling; 2 pirfenidone, an anti-fibrosis drug to block TGF-beta signaling; 3 rifabutin, an antibiotic to block beta-catenin signaling; 4 metformin, a first-line antidiabetic drug to stimulate AMPK and inhibit mammalian target of rapamycin, (mTOR; 5 propranolol, a beta-blocker to block beta

  6. SutraGUI, a graphical-user interface for SUTRA, a model for ground-water flow with solute or energy transport

    Science.gov (United States)

    Winston, Richard B.; Voss, Clifford I.

    2004-01-01

    This report describes SutraGUI, a flexible graphical user-interface (GUI) that supports two-dimensional (2D) and three-dimensional (3D) simulation with the U.S. Geological Survey (USGS) SUTRA ground-water-flow and transport model (Voss and Provost, 2002). SutraGUI allows the user to create SUTRA ground-water models graphically. SutraGUI provides all of the graphical functionality required for setting up and running SUTRA simulations that range from basic to sophisticated, but it is also possible for advanced users to apply programmable features within Argus ONE to meet the unique demands of particular ground-water modeling projects. SutraGUI is a public-domain computer program designed to run with the proprietary Argus ONE? package, which provides 2D Geographic Information System (GIS) and meshing support. For 3D simulation, GIS and meshing support is provided by programming contained within SutraGUI. When preparing a 3D SUTRA model, the model and all of its features are viewed within Argus 1 in 2D projection. For 2D models, SutraGUI is only slightly changed in functionality from the previous 2D-only version (Voss and others, 1997) and it provides visualization of simulation results. In 3D, only model preparation is supported by SutraGUI, and 3D simulation results may be viewed in SutraPlot (Souza, 1999) or Model Viewer (Hsieh and Winston, 2002). A comprehensive online Help system is included in SutraGUI. For 3D SUTRA models, the 3D model domain is conceptualized as bounded on the top and bottom by 2D surfaces. The 3D domain may also contain internal surfaces extending across the model that divide the domain into tabular units, which can represent hydrogeologic strata or other features intended by the user. These surfaces can be non-planar and non-horizontal. The 3D mesh is defined by one or more 2D meshes at different elevations that coincide with these surfaces. If the nodes in the 3D mesh are vertically aligned, only a single 2D mesh is needed. For nonaligned

  7. Characteristics of a novel treatment system for linear accelerator-based stereotactic radiosurgery.

    Science.gov (United States)

    Wen, Ning; Li, Haisen; Song, Kwang; Chin-Snyder, Karen; Qin, Yujiao; Kim, Jinkoo; Bellon, Maria; Gulam, Misbah; Gardner, Stephen; Doemer, Anthony; Devpura, Suneetha; Gordon, James; Chetty, Indrin; Siddiqui, Farzan; Ajlouni, Munther; Pompa, Robert; Hammoud, Zane; Simoff, Michael; Kalkanis, Steven; Movsas, Benjamin; Siddiqui, M Salim

    2015-07-08

    deviation between the OSMS and CBCT was -0.4 ± 0.2 mm, 0.1± 0.3mm, and 0.0 ± 0.1 mm in the vertical, longitudinal, and lateral directions. The mean values and standard deviations of the average deviation and maximum deviation of the daily Winston-Lutz tests over three months are 0.20 ± 0.03 mm and 0.66 ± 0.18 mm, respectively. Initial testing of this novel system demonstrates the technology to be highly accurate and suitable for frameless, linac-based SRS and SBRT treatment.

  8. Book Reviews

    Directory of Open Access Journals (Sweden)

    N.J. Gubser

    1968-01-01

    Full Text Available - Ward H. Goodenough, Frederick Barth, Models of social organization. Royal Anthropological Institute Occasional Paper No. 23. Royal Anthropological Institute of Great Britain and Ireland, London 1966. Pp. vi, 33. - E. Postel-Coster, Carl A. Schmitz, Grundformen der Verwandtschaft. Basler Beiträge zur Geographie und Ethnologie, Ethnologische Reihe Heft I. Pharos-Verlag Hansrudolf Schwabe AG, Basel 1964. 134 pp. - B. Siertsema, John J. Gumperz, “The ethnography of communication”; Special publication of American Anthropologist, Part 2, Vol. 66, no. 6, December 1964. American Anthropological Association, Menasha, Wisconsin, U.S.A., 1964, 186 pp., Dell Hymes (eds. - J. Voorhoeve, William J. Samarin, Field Linguistics. A guide to linguistic fieldwork. Holt, Rinehart & Winston Inc., New York, etc., 1967. X + 246 pp. - P.J.R. Modderman, André Leroi-Gourhan, La geste et la parole. Albin Michel, Paris 1964. 2 dln., 300 en 268 pp. Vele ills. - David F. Pocock, Andre Beteille, Caste, class and power. Changing patterns of stratification in a Tanjore village. University of California Press, Berkeley 1965. 225 pp. - A. Trouwborst, P.C. Lloyd, The new elites of tropical Africa. Studies presented and discussed at the sixth international African seminar at the University of Ibadan, Nigeria, July 1964 . Foreword by Daryll Forde. Introduction by P.C. Lloyd. Published for the International African Institute by the Oxford University Press. London 1966. X + 390 pp. - F.L. van Holthoon, Darryll Forde, West African Kingdoms in the 19th. century. O.U.P. for the International African Institute, London 1967. 281 pp., P.M. Kaberry (eds. - J.J. Romkes, David W. Brokensha, Social change at Larteh, Ghana. Clarendon Press. Oxford University Press. London 1966. 294 pp., 5 plates, 3 maps. - A.J.C. Lach de Bère, Merran Fraenkel, Tribe and class in Monrovia. Oxford University Press for the International African Institute, London, Ibadan, Accra, 1964; 244 blz. - F.L. van

  9. Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Kempton CL

    2017-09-01

    Full Text Available Christine L Kempton,1 Michael Wang,2 Michael Recht,3 Anne Neff,4 Amy D Shapiro,5 Amit Soni,6 Roshni Kulkarni,7 Tyler W Buckner,2 Katharine Batt,8 Neeraj N Iyer,9 David L Cooper9 1Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA; 2Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, CO, USA; 3The Hemophilia Center, Oregon Health & Science University, Portland, OR, USA; 4Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA; 5Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA; 6Center for Inherited Blood Disorders and CHOC Children’s Hospital/UC Irvine, Orange, CA, USA; 7MSU Center for Bleeding and Clotting Disorders, Michigan State University, East Lansing, MI, USA; 8Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 9Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA Background: Hemophilia is marked by frequent joint bleeding, resulting in pain and functional impairment.Objective: This study aimed to assess the reliability of five patient-reported outcome (PRO instruments in people with hemophilia (PWH in a non-bleeding state.Methods: Adult male PWH of any severity and inhibitor status, with a history of joint pain or bleeding, completed a pain history and five PRO instruments (EQ-5D-5L, Brief Pain Inventory v2 [BPI], International Physical Activity Questionnaire [IPAQ], Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL] during their routine comprehensive care visit. Patients were approached to complete the PRO instruments again at the end of their visit while in a similar non-bleeding state. Concordance of individual questionnaire items and correlation between domain scores were assessed using intra-class correlation coefficient (ICC.Results: Participants completing the retest (n=164 had a median age of 33.9 years. Median time for

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-07-01

    Full Text Available -Alan L. Karras, Lauren A. Benton, Law and colonial cultures: Legal regimes in world history, 1400-1900. Cambridge: Cambridge University Press, 2002. xiii + 285 pp. -Sidney W. Mintz, Douglass Sullivan-González ,The South and the Caribbean. Jackson: University Press of Mississippi, 2001. xii + 208 pp., Charles Reagan Wilson (eds -John Collins, Peter Redfield, Space in the tropics: From convicts to rockets in French Guiana. Berkeley: University of California Press, 2000. xiii + 345 pp. -Vincent Brown, Keith Q. Warner, On location: Cinema and film in the Anglophone Caribbean. Oxford: Macmillan, 2000. xii + 194 pp. -Ann Marie Stock, Jacqueline Barnitz, Twentieth-century art of Latin America. Austin: University of Texas Press, 2001. 416 pp. -Ineke Phaf, J.J. Oversteegen, Herscheppingen: De wereld van José Maria Capricorne. Emmastad, Curacao: Uitgeverij ICS Nederland/Curacao, 1999. 168 pp. -Halbert Barton, Frances R. Aparicio, Listening to Salsa: Gender, latin popular music, and Puerto Rican cultures. Hanover NH: Wesleyan University Press, 1998. xxi + 290 pp. -Pedro Pérez Sarduy, John M. Kirk ,Culture and the Cuban revolution: Conversations in Havana. Gainesville: University Press of Florida, 2001. xxvi + 188 pp., Leonardo Padura Fuentes (eds -Luis Martínez-Fernández, Damián J. Fernández, Cuba and the politics of passion. Austin: University of Texas Press, 2000. 192 pp. -Eli Bartra, María de Los Reyes Castillo Bueno, Reyita: The life of a black Cuban woman in the twentieth century. Durham NC: Duke University Press, 2000. 182 pp. -María del Carmen Baerga, Felix V. Matos Rodríguez, Women and urban change in San Juan, Puerto Rico, 1820-1868. Gainesville: University Press of Florida, 1999. xii + 180 pp. [Reissued in 2001 as: Women in San Juan, 1820-1868. Princeton NJ: Markus Weiner Publishers.] -Kevin A. Yelvington, Winston James, Holding aloft the banner of Ethiopa: Caribbean radicalism in early twentieth-century America. New York: Verso, 1998

  11. SUPPORT FOR HU CFRT SUMMER HIGH SCHOOL FUSION WORKSHOP

    International Nuclear Information System (INIS)

    Punjabi, Alkesh

    2010-01-01

    researchers in the HU CFRT mentor the students during summers. Mentors spend a considerable amount of time and efforts in training, teaching, guiding and supervising research projects. The HU CFRT has so far conducted nine workshops during the summers of 1996-2000 and 2002-2005. The first workshop was conducted in summer 1996. Students for the workshop are chosen from a national pool of exceptionally talented high school rising seniors/juniors. To our knowledge, most of these students have gone on to prestigious universities such as Duke University, John Hopkins University, CalTech, UCLA, Hampton University, etc. after completing their high school. For instance, Tiffany Fisher, participant of the 1996 summer workshop completed her BS in Mathematics at Hampton University in May 2001. She then went on to Wake Forest University at Winston-Salem, North Carolina to pursue graduate studies. Anshul Haldipur, participant of the 1999 summer workshop, began his undergraduate studies at Duke University in 2000. Christina Nguyen and Ilissa Martinez, participants of the 2000 summer workshop, are pursuing their undergraduate degrees at the UCLA and Florida State University respectively. The organizing committee of the APS DPP annual meeting invited Dr. Punjabi to deliver an invited talk on training the next generation of fusion scientists and engineers at the 2005 APS DPP meeting in Denver, CO. The organizing committee distributed a special flier with the Bulletin to highlight this invited talk and another talk on education as well the expo. This has given wide publicity and recognition to our workshops and Hampton University. Prof. Punjabi's talk: 'LI2 2: Training the next generation of fusion scientists and engineers: summer high school fusion science workshop, Bull. Amer. Phys. Soc. 50, 221 (2005)' was very well-received. He talked about HU education and outreach initiative and the HU CFRT Summer High School Workshop. The audience had a considerable number of questions about our

  12. Formal Semantics: Origins, Issues, Early Impact

    Directory of Open Access Journals (Sweden)

    Barbara H. Partee

    2010-12-01

    Full Text Available Formal semantics and pragmatics as they have developed since the late 1960's have been shaped by fruitful interdisciplinary collaboration among linguists, philosophers, and logicians, among others, and in turn have had noticeable effects on developments in syntax, philosophy of language, computational linguistics, and cognitive science.In this paper I describe the environment in which formal semantics was born and took root, highlighting the differences in ways of thinking about natural language semantics in linguistics and in philosophy and logic. With Montague as a central but not solo player in the story, I reflect on crucial developments in the 1960's and 70's in linguistics and philosophy, and the growth of formal semantics and formal pragmatics from there. I discuss innovations, key players, and leading ideas that shaped the development of formal semantics and its relation to syntax, to pragmatics, and to the philosophy of language in its early years, and some central aspects of its early impact on those fields.ReferencesAbbott, B. 1999. ‘The formal approach to meaning: Formal semantics and its recent developments’. Journal of Foreign Languages (Shanghai119, no. 1: 2–20. https://www.msu.edu/~abbottb/formal.htm.Ajdukiewicz, K. 1960. Je¸zyk i Poznanie (Language and Knowledge. Warsaw.Bach, E. 1968. ‘Nouns and Noun Phrases’. In E. Bach & R.T. Harms (eds. ‘Universals in Linguistic Theory’, 90–122. NY: Holt, Rinehart & Winston.Bach, E. 1989. Informal Lectures on Formal Semantics. New York: State University of New York Press.Bar-Hillel, Y. 1954a. ‘Logical syntax and semantics’. Language 30: 230–237.http://dx.doi.org/10.2307/410265Bar-Hillel, Y. 1954b. ‘Indexical Expressions’. Mind 63: 359–379.http://dx.doi.org/10.1093/mind/LXIII.251.359Bar-Hillel, Y. 1963. ‘Remarks on Carnap’s Logical Syntax of Language’. In P. A. Schilpp (ed. ‘The Philosophy of Rudolf Carnap’, 519–543. LaSalle, Illinois / London: Open

  13. Three essays on the incentive structure of energy conservation programs

    Science.gov (United States)

    Okwelum, Edson Ogochukwu

    of it being involved in a fatal accident. The external costs translate to about 38 cents/gallon of gasoline. Chapter III explores how individual unobserved heterogeneity in tastes could lead to different customers sorting into different classes of fuel efficient vehicles and therefore affect estimates of consumer's ability to tradeoff vehicle costs and discounted future gasoline costs. The research question is important for several reasons. First, it is interesting from a theoretical basis if consumers make this trade off optimally. Many theoretical models in economics make the fundamental assumption that consumers equally weigh current and future events when making decisions today. However, plenty empirical and laboratory evidence conclude the contrary. Second, Regulatory Impact Analyses (RIA) of regulations on energy efficiency standards usually find that the benefits of these programs are in many times larger than the costs, with the fuel savings over the life of the vehicle accounting for the majority of the benefits. However, if fuel savings are large relative to costs, then the question is why are manufacturers not incorporating these technologies in their product offerings? Therefore understanding energy paradox is critical for evaluating the standards and regulations so that policy makers can identify baseline for assessment in cost-benefit analyses. In this paper, we contribute to the literature on Energy Paradox in Fuel Economy by providing empirical evidence that unobserved consumer heterogeneity could result in different consumers sorting into different classes of fuel efficient cars which results in consumers undervaluing fuel economy. Unlike existing literature in this topic, this paper accounts for sorting bias due unobserved heterogeneity by using a random coefficient logit with error components (Train and Winston 2007). We pair the random coefficient discrete choice model with a supply side model in which firms compete in Bertrand Nash fashion where