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Sample records for wingless-type mmtv integration

  1. Lactation Defect in a Widely Used MMTV-Cre Transgenic Line of Mice

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    Yuan, Taichang; Wang, Yongping; Pao, Lily; Anderson, Steve M.; Gu, Haihua

    2011-01-01

    Background MMTV-Cre mouse lines have played important roles in our understanding about the functions of numerous genes in mouse mammary epithelial cells during mammary gland development and tumorigenesis. However, numerous studies have not included MMTV-Cre mice as controls, and many investigators have not indicated which of the different MMTV-Cre founder lines were used in their studies. Here, we describe a lactation defect that severely limits the use of one of the most commonly used MMTV-Cre founder lines. Methodology/Principal Findings To explore the role of protein tyrosine phosphatase Shp1 in mammary gland development, mice bearing the floxed Shp1 gene were crossed with MMTV-Cre mice and mammary gland development was examined by histological and biochemical techniques, while lactation competency was assessed by monitoring pup growth. Surprisingly, both the Shp1fl/+;MMTV-Cre and MMTV-Cre female mice displayed a severe lactation defect when compared to the Shp1 fl/+ control mice. Histological and biochemical analyses reveal that female mice expressing the MMTV-Cre transgene, either alone or in combination with floxed genes, exhibit defects in lobuloalveolar expansion, presence of large cytoplasmic lipid droplets in luminal alveolar epithelial cells postpartum, and precocious induction of involution. Using a PCR-based genotyping method, the three different founder lines can be distinguished, and we determined that the MMTV-Cre line A, the most widely used MMTV-Cre founder line, exhibits a profound lactation defect that limits its use in studies on mammary gland development. Conclusions/Significance The identification of a lactation defect in the MMTV-Cre line A mice indicates that investigators must use MMTV-Cre alone mice as control in studies that utilize Cre recombinase to excise genes of interest from mammary epithelial cells. Our results also suggest that previous results obtained in studies using the MMTV-Cre line A line should be re-evaluated if the

  2. Cullin4B/E3-ubiquitin ligase negatively regulates β-catenin

    Indian Academy of Sciences (India)

    -catenin is the key transducer of Wingless-type MMTV integration site family member (Wnt) signalling, upregulation of which is the cause of cancer of the colon and other tissues. In the absence of Wnt signals, -catenin is targeted to ubiquitin–proteasome-mediated degradation. Here we present the functional ...

  3. Cullin4B/E3-ubiquitin ligase negatively regulates β-catenin

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    Introduction. Wingless-type MMTV integration site family member. (Wnt) signalling is one of the important signal transduction pathways regulating several events during growth and development, and is also implicated in a variety of cancers. (reviewed in Polakis 1997). Stabilization of β-catenin, a highly oncogenic protein, is ...

  4. Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

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    Dudley Jaquelin P

    2009-02-01

    Full Text Available Abstract Background Mouse mammary tumor virus (MMTV encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV, human T-cell leukemia virus (HTLV, and human endogenous retrovirus type K (HERV-K. In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE. Results MMTV Rem, HIV Rev, and HTLV Rex proteins, but not HERV-K Rec, enhanced expression from an MMTV-based reporter plasmid in human T cells, and this activity was dependent on the RmRE. No RmRE-dependent reporter gene expression was detectable using Rev, Rex, or Rec in HC11 mouse mammary cells. Cell fractionation and RNA quantitation experiments suggested that the regulatory proteins did not affect RNA stability or nuclear export in the MMTV reporter system. Rem had no demonstrable activity on export elements from HIV, HTLV, or HERV-K. Similar to the Rem-specific activity in rodent cells, the RmRE-dependent functions of Rem, Rev, or Rex in human cells were inhibited by a dominant-negative truncated nucleoporin that acts in the Crm1 pathway of RNA and protein export. Conclusion These data argue that many retroviral regulatory proteins recognize similar complex RNA structures, which may depend on the presence of cell-type specific proteins. Retroviral protein activity on the RmRE appears to affect a post-export function of the reporter RNA. Our results provide additional evidence that MMTV is a complex retrovirus with the potential for viral interactions in human cells.

  5. Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

    International Nuclear Information System (INIS)

    Rossum, Agnes GSH van; Bragt, Maaike PA van; Schuuring-Scholtes, Ellen; Ploeg, Jan CM van der; Krieken, Johan HJM van; Kluin, Philip M; Schuuring, Ed

    2006-01-01

    In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because overexpression of both proteins, respectively cyclin D1 and cortactin, correlated well with 11q13 amplification. Cyclin D1 is involved in cell cycle regulation and the F-actin-binding protein cortactin in cytoskeletal dynamics and cell migration. To study the role of cortactin in mammary gland tumorigenesis, we examined mouse mammary tumor virus (MMTV)-cortactin transgenic mice and MMTV-cortactin/-MMTV-cyclin D1 bitransgenic mice. MMTV-cortactin transgenic mice were generated and intercrossed with previously described MMTV-cyclin D1 transgenic mice. Immunohistochemical, Northern and Western blot analyses were performed to study the expression of human transgene cortactin during mammary gland development and in mammary tumors. For tumor incidence studies, forced-bred, multiparous mice were used to enhance transgene expression in the mammary gland. Microscopical examination was performed using haematoxylin and eosin staining. Mammary gland tumors arose stochastically (incidence 21%) with a mean age of onset at 100 weeks. This incidence, however, did not exceed that of aged-matched control FVB/N mice (38%), which unexpectedly, also developed spontaneous mammary gland tumors. We mimicked 11q13 amplification by generating MMTV-cortactin/-MMTV-cyclin D1 bitransgenic mice but did not observe any synergistic effect of cortactin on cyclin D1-induced mammary hyperplasias or carcinomas, nor development of distant metastasis. From this study, we conclude that development of (pre-malignant) breast tumors in either wild type or MMTV-cyclin D1 mice was not augmented due to mammary gland targeted overexpression of human cortactin

  6. Structural basis of genomic RNA (gRNA) dimerization and packaging determinants of mouse mammary tumor virus (MMTV).

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    Aktar, Suriya J; Vivet-Boudou, Valérie; Ali, Lizna M; Jabeen, Ayesha; Kalloush, Rawan M; Richer, Delphine; Mustafa, Farah; Marquet, Roland; Rizvi, Tahir A

    2014-11-14

    One of the hallmarks of retroviral life cycle is the efficient and specific packaging of two copies of retroviral gRNA in the form of a non-covalent RNA dimer by the assembling virions. It is becoming increasingly clear that the process of dimerization is closely linked with gRNA packaging, and in some retroviruses, the latter depends on the former. Earlier mutational analysis of the 5' end of the MMTV genome indicated that MMTV gRNA packaging determinants comprise sequences both within the 5' untranslated region (5' UTR) and the beginning of gag. The RNA secondary structure of MMTV gRNA packaging sequences was elucidated employing selective 2'hydroxyl acylation analyzed by primer extension (SHAPE). SHAPE analyses revealed the presence of a U5/Gag long-range interaction (U5/Gag LRI), not predicted by minimum free-energy structure predictions that potentially stabilizes the global structure of this region. Structure conservation along with base-pair covariations between different strains of MMTV further supported the SHAPE-validated model. The 5' region of the MMTV gRNA contains multiple palindromic (pal) sequences that could initiate intermolecular interaction during RNA dimerization. In vitro RNA dimerization, SHAPE analysis, and structure prediction approaches on a series of pal mutants revealed that MMTV RNA utilizes a palindromic point of contact to initiate intermolecular interactions between two gRNAs, leading to dimerization. This contact point resides within pal II (5' CGGCCG 3') at the 5' UTR and contains a canonical "GC" dyad and therefore likely constitutes the MMTV RNA dimerization initiation site (DIS). Further analyses of these pal mutants employing in vivo genetic approaches indicate that pal II, as well as pal sequences located in the primer binding site (PBS) are both required for efficient MMTV gRNA packaging. Employing structural prediction, biochemical, and genetic approaches, we show that pal II functions as a primary point of contact between

  7. Endogenization of mouse mammary tumor virus (MMTV)-like elements in genomes of pikas (Ochotona sp.).

    Science.gov (United States)

    Lemos de Matos, Ana; de Sousa-Pereira, Patrícia; Lissovsky, Andrey A; van der Loo, Wessel; Melo-Ferreira, José; Cui, Jie; Esteves, Pedro J

    2015-12-02

    Despite the finding in European rabbit and other leporid genomes of the first ever described endogenous lentivirus and of a European rabbit exclusive endogenous gammaretrovirus, until now no exogenous retroviruses have been isolated in Lagomorpha species. Nevertheless, looking for the presence of endogenous retroviruses (ERVs) in the species genomes could lead to the discovery of retroviral lineages yet to be found in Lagomorpha. Different mammalian genomes harbor endogenous viral sequences phylogenetically close to the betaretrovirus mouse mammary tumor virus (MMTV), propelling us to look for such retroviral "fossil" in American pika (Ochotona princeps) and European rabbit (Oryctolagus cuniculus) genomes. By performing genomic mining using MMTV gag and LTR as query sequences, we found that such viral elements were absent from the European rabbit genome. Oppositely, significant matches were found in American pika, and more importantly, a nearly complete MMTV-like virus (Pika-BERV) was identified. Using Pika-BERV gag and LTR as templates, we found similar sequences endogenized in different pika (Ochotona sp.) species. The orthology of the LTR flanking region between some pika species supported shared ancestry of specific endogenous betaretroviruses, while in other pika species similar sequences, but not orthologous, should have resulted from independent insertions. Our study supports the possible existence of infecting exogenous betaretroviruses for a long term, after the divergence of Ochotonidae from Leporidae, but yet to be identified. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.

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    Dadi Jiang

    Full Text Available p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions. To investigate these gain-of-function effects in vivo, we generated mice of three different genotypes: MMTV-Hras/p53(+/+, MMTV-Hras/p53(-/-, and MMTV-Hras/p53R172H/R172H. Salivary tumors from these mice were characterized with regard to age of tumor onset, tumor growth rates, cell cycle distribution, apoptotic levels, tumor histopathology, as well as response to doxorubicin treatment. Microarray analysis was also performed to profile gene expression. The MMTV-Hras/p53(-/- and MMTV-Hras/p53R172H/R172H mice displayed similar properties with regard to age of tumor onset, tumor growth rates, tumor histopathology, and response to doxorubicin, while both groups were clearly distinct from the MMTV-Hras/p53(+/+ mice by these measurements. In addition, the gene expression profiles of the MMTV-Hras/p53(-/- and MMTV-Hras/p53(R172H/R172H tumors were tightly clustered, and clearly distinct from the profiles of the MMTV-Hras/p53(+/+ tumors. Only a small group of genes showing differential expression between the MMTV-Hras/p53(-/- and MMTV-Hras/p53(R172H/R172H tumors, that did not appear to be regulated by wild-type p53, were identified. Taken together, these results indicate that in this MMTV-Hras-driven salivary tumor model, the major effect of the p53 R172H mutant is due to the loss of wild-type p53 function, with little or no gain-of-function effect on tumorigenesis, which may be explained by the tissue- and tumor type-specific properties of this gain-of-function mutant of p53.

  9. PCBs Exert an Estrogenic Effect through Repression of the Wnt7a Signaling Pathway in the Female Reproductive Tract

    OpenAIRE

    Ma, Risheng; Sassoon, David A.

    2006-01-01

    Polychlorinated biphenyls (PCBs) have been proposed to have a weak estrogenic activity and therefore pose a risk as potential environmental endocrine disruptors to the perinatal development of the female reproductive tract. Perinatal exposure to high concentrations of the potent synthetic estrogen diethylstilbestrol (DES) induces abnormal development of the female reproductive tract via a mechanism that acts through the down-regulation of Wnt7a (wingless-type MMTV integration site family, mem...

  10. High-fat diet enhances mammary tumorigenesis and pulmonary metastasis and alters inflammatory and angiogenic profiles in MMTV-PyMT mice

    Science.gov (United States)

    The MMTV-PyMT transgenic mouse model is commonly used to study luminal B breast cancer, which has a lower prevalence but a worse prognosis. The objective of the present study was to determine whether an obesogenic, high-fat diet enhances primary tumorigenesis and pulmonary metastasis in female MMTV...

  11. Sequences within both the 5' UTR and Gag are required for optimal in vivo packaging and propagation of mouse mammary tumor virus (MMTV genomic RNA.

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    Farah Mustafa

    Full Text Available BACKGROUND: This study mapped regions of genomic RNA (gRNA important for packaging and propagation of mouse mammary tumor virus (MMTV. MMTV is a type B betaretrovirus which preassembles intracellularly, a phenomenon distinct from retroviruses that assemble the progeny virion at cell surface just before budding such as the type C human and feline immunodeficiency viruses (HIV and FIV. Studies of FIV and Mason-Pfizer monkey virus (MPMV, a type D betaretrovirus with similar intracellular virion assembly processes as MMTV, have shown that the 5' untranslated region (5' UTR and 5' end of gag constitute important packaging determinants for gRNA. METHODOLOGY: Three series of MMTV transfer vectors containing incremental amounts of gag or 5' UTR sequences, or incremental amounts of 5' UTR in the presence of 400 nucleotides (nt of gag were constructed to delineate the extent of 5' sequences that may be involved in MMTV gRNA packaging. Real time PCR measured the packaging efficiency of these vector RNAs into MMTV particles generated by co-transfection of MMTV Gag/Pol, vesicular stomatitis virus envelope glycoprotein (VSV-G Env, and individual transfer vectors into human 293T cells. Transfer vector RNA propagation was monitored by measuring transduction of target HeLaT4 cells following infection with viral particles containing a hygromycin resistance gene expression cassette on the packaged RNA. PRINCIPAL FINDINGS: MMTV requires the entire 5' UTR and a minimum of ~120 nucleotide (nt at the 5' end of gag for not only efficient gRNA packaging but also propagation of MMTV-based transfer vector RNAs. Vector RNAs without the entire 5' UTR were defective for both efficient packaging and propagation into target cells. CONCLUSIONS/SIGNIFICANCE: These results reveal that the 5' end of MMTV genome is critical for both gRNA packaging and propagation, unlike the recently delineated FIV and MPMV packaging determinants that have been shown to be of bipartite nature.

  12. Comparison of Expression Profiles of Metastatic versus Primary Mammary Tumors in MMTV-Wnt-1 and MMTV-Neu Transgenic Mice

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    Shixia Huang

    2008-02-01

    Full Text Available Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling. The mechanism behind this lack of similarity between individual metastases is not known. We used cDNA microarrays to determine the expression profiles of pulmonary metastases and primary mammary tumors in two distinct transgenic models expressing either the Neu or the Wnt-1 oncogene from the mouse mammary tumor virus long terminal repeat (MMTV LTR. We found that pulmonary metastases are similar to each other and to their primary tumors within the same line. However, metastases arising in one transgenic mouse line are very different from either metastases or primary tumors arising in the other line. In addition, we found that, like their primary tumors, lung metastases in Wnt-1 transgenic mice harbor both epithelial and myoepithelial tumor cells and cells that express the putative progenitor cell marker keratin 6. Our data suggest that both gene expression profiles and cellular heterogeneity are preserved after breast cancer has spread to distant sites, and that metastases are similar to each other when their primary tumors were induced by the same oncogene and from the same subset of mammary cells.

  13. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

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    Janice B B Lam

    Full Text Available Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive.In the present study, MMTV-polyomavirus middle T antigen (MMTV-PyVT transgenic mice with reduced adiponectin expressions were established and the stromal effects of adiponectin haploinsufficiency on mammary tumor development evaluated. In mice from both FVB/N and C57BL/6J backgrounds, insufficient adiponectin production promoted mammary tumor onset and development. A distinctive basal-like subtype of tumors, with a more aggressive phenotype, was derived from adiponectin haplodeficient MMTV-PyVT mice. Comparing with those from control MMTV-PyVT mice, the isolated mammary tumor cells showed enhanced tumor progression in re-implanted nude mice, accelerated proliferation in primary cultures, and hyperactivated phosphatidylinositol-3-kinase (PI3K/Akt/beta-catenin signaling, which at least partly attributed to the decreased phosphatase and tensin homolog (PTEN activities. Further analysis revealed that PTEN was inactivated by a redox-regulated mechanism. Increased association of PTEN-thioredoxin complexes was detected in tumors derived from mice with reduced adiponectin levels. The activities of thioredoxin (Trx1 and thioredoxin reductase (TrxR1 were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells. Moreover, adiponectin could inhibit TrxR1 promoter-mediated transcription and restore the mRNA expressions of TrxR1.Adiponectin haploinsufficiency facilitated mammary tumorigenesis by down-regulation of PTEN activity and activation of PI3K/Akt signalling pathway through a mechanism involving Trx1/TrxR1

  14. Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter

    International Nuclear Information System (INIS)

    Astrand, Carolina; Belikov, Sergey; Wrange, Orjan

    2009-01-01

    Transcription from the mouse mammary tumor virus (MMTV) promoter is induced by the glucocorticoid receptor (GR). This switch was reconstituted in Xenopus oocytes. Previously, we showed that Nuclear Factor 1 (NF1) and Octamer Transcription Factor 1 (Oct1) bind constitutively to the MMTV promoter and thereby induce translational nucleosome positioning representing an intermediary, i.e. preset, state of nucleosome organization. Here we further characterize this NF1 and Oct1 induced preset chromatin in relation to the inactive and the hormone-activated state. The preset chromatin exhibits increased histone acetylation but does not cause dissociation of histone H1 as oppose to the hormone-activated state. Furthermore, upon hormone induction the preset MMTV chromatin displays an enhanced and prolonged GR binding capacity and transcription during an intrinsic and time-dependent silencing of the injected template. The silencing process correlates with a reduced histone acetylation. However, a histone deacetylase inhibitor, trichostatin A (TSA), does not counteract silencing in spite of its distinct stimulation of GR-DNA binding. The latter indicates the importance of histone acetylation to maintain DNA access for inducible factor binding. We discuss how constitutively bound factors such as NF1 and Oct1 may participate in the maintenance of tissue specificity of hormone responsive genes.

  15. Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter

    Energy Technology Data Exchange (ETDEWEB)

    Astrand, Carolina, E-mail: ca340@cam.ac.uk [Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm (Sweden); Belikov, Sergey, E-mail: Sergey.Belikov@ki.se [Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm (Sweden); Wrange, Orjan, E-mail: Orjan.Wrange@ki.se [Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm (Sweden)

    2009-09-10

    Transcription from the mouse mammary tumor virus (MMTV) promoter is induced by the glucocorticoid receptor (GR). This switch was reconstituted in Xenopus oocytes. Previously, we showed that Nuclear Factor 1 (NF1) and Octamer Transcription Factor 1 (Oct1) bind constitutively to the MMTV promoter and thereby induce translational nucleosome positioning representing an intermediary, i.e. preset, state of nucleosome organization. Here we further characterize this NF1 and Oct1 induced preset chromatin in relation to the inactive and the hormone-activated state. The preset chromatin exhibits increased histone acetylation but does not cause dissociation of histone H1 as oppose to the hormone-activated state. Furthermore, upon hormone induction the preset MMTV chromatin displays an enhanced and prolonged GR binding capacity and transcription during an intrinsic and time-dependent silencing of the injected template. The silencing process correlates with a reduced histone acetylation. However, a histone deacetylase inhibitor, trichostatin A (TSA), does not counteract silencing in spite of its distinct stimulation of GR-DNA binding. The latter indicates the importance of histone acetylation to maintain DNA access for inducible factor binding. We discuss how constitutively bound factors such as NF1 and Oct1 may participate in the maintenance of tissue specificity of hormone responsive genes.

  16. MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors.

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    Brigitte Teissedre

    Full Text Available Canonical Wnt/beta-catenin signaling regulates stem/progenitor cells and, when perturbed, induces many human cancers. A significant proportion of human breast cancer is associated with loss of secreted Wnt antagonists and mice expressing MMTV-Wnt1 and MMTV-DeltaN89beta-catenin develop mammary adenocarcinomas. Many studies have assumed these mouse models of breast cancer to be equivalent. Here we show that MMTV-Wnt1 and MMTV-DeltaN89beta-catenin transgenes induce tumors with different phenotypes. Using axin2/conductin reporter genes we show that MMTV-Wnt1 and MMTV-DeltaN89beta-catenin activate canonical Wnt signaling within distinct cell-types. DeltaN89beta-catenin activated signaling within a luminal subpopulation scattered along ducts that exhibited a K18(+ER(-PR(-CD24(highCD49f(low profile and progenitor properties. In contrast, MMTV-Wnt1 induced canonical signaling in K14(+ basal cells with CD24/CD49f profiles characteristic of two distinct stem/progenitor cell-types. MMTV-Wnt1 produced additional profound effects on multiple cell-types that correlated with focal activation of the Hedgehog pathway. We document that large melanocytic nevi are a hitherto unreported hallmark of early hyperplastic Wnt1 glands. These nevi formed along the primary mammary ducts and were associated with Hedgehog pathway activity within a subset of melanocytes and surrounding stroma. Hh pathway activity also occurred within tumor-associated stromal and K14(+/p63(+ subpopulations in a manner correlated with Wnt1 tumor onset. These data show MMTV-Wnt1 and MMTV-DeltaN89beta-catenin induce canonical signaling in distinct progenitors and that Hedgehog pathway activation is linked to melanocytic nevi and mammary tumor onset arising from excess Wnt1 ligand. They further suggest that Hedgehog pathway activation maybe a critical component and useful indicator of breast tumors arising from unopposed Wnt1 ligand.

  17. Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice

    International Nuclear Information System (INIS)

    Wong, Patrick S; Matsumura, Fumio

    2007-01-01

    Exposure to β-Hexachlorocyclohexane (β-HCH), a contaminant of the hexachlorohexane pesticide lindane, has been implicated as a risk factor in the development of breast cancers in epidemiological studies. Previous studies in our laboratory have demonstrated the ability of β-HCH to elicit its actions via a ligand-independent activation of the estrogen receptor through increased c-Neu (= erbB 2 or HER-2) expression and kinase activation in both the BG-1 and MCF-7 cell lines. In addition, long term exposure (33 passages) to β-HCH was shown to promote the selection of MCF-7 cells which exhibit a more metastatic phenotype. In this current study, we decided to investigate the long-term effects of β-HCH in both the MCF10AT1 cell line which was derived from a normal epithelial cell line by stably transfecting a mutated c-Ha-ras and a MMTV-Neu mouse model for mammary cancer in vivo. MCF10AT1 cells were exposed for 20 passages with β-HCH, 4-OH-Tamoxifen (Tam), or 17-β-estradiol (E 2 ) after which cells were analyzed for proliferation rates and mRNA expression by RT-PCR. In our in vivo studies, MMTV-Neu mice were injected with β-HCH and observed for tumor formation over a 70 week period. β-HCH and Tam selected MCF10AT1 cells demonstrated increased mRNA expression of MMP-13 (collagenase-3) a marker of increased invasiveness. β-HCH treatment was also seen to increase the expression in a number of proto-oncogenes (c-Neu, Cyclin D1, p27), cell status markers (Met-1, CK19), and the inflammatory marker NFκB. Previous studies, have demonstrated the role of these markers as evidence of malignant transformations, and further illustrate the ability of β-HCH to be carcinogenic. To demonstrate β-HCH's tumorigenic properties in an in vivo system, we used an MMTV-Neu mouse model. MMTV-Neu is a c-Neu overexpressing strain which has been shown to spontaneously develop mammary tumors at later stages of aging. In this experiment, β-HCH exposure was shown to both accelerate

  18. Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice

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    Matsumura Fumio

    2007-07-01

    Full Text Available Abstract Background Exposure to β-Hexachlorocyclohexane (β-HCH, a contaminant of the hexachlorohexane pesticide lindane, has been implicated as a risk factor in the development of breast cancers in epidemiological studies. Previous studies in our laboratory have demonstrated the ability of β-HCH to elicit its actions via a ligand-independent activation of the estrogen receptor through increased c-Neu (= erbB2 or HER-2 expression and kinase activation in both the BG-1 and MCF-7 cell lines. In addition, long term exposure (33 passages to β-HCH was shown to promote the selection of MCF-7 cells which exhibit a more metastatic phenotype. Methods In this current study, we decided to investigate the long-term effects of β-HCH in both the MCF10AT1 cell line which was derived from a normal epithelial cell line by stably transfecting a mutated c-Ha-ras and a MMTV-Neu mouse model for mammary cancer in vivo. MCF10AT1 cells were exposed for 20 passages with β-HCH, 4-OH-Tamoxifen (Tam, or 17-β-estradiol (E2 after which cells were analyzed for proliferation rates and mRNA expression by RT-PCR. In our in vivo studies, MMTV-Neu mice were injected with β-HCH and observed for tumor formation over a 70 week period. Results β-HCH and Tam selected MCF10AT1 cells demonstrated increased mRNA expression of MMP-13 (collagenase-3 a marker of increased invasiveness. β-HCH treatment was also seen to increase the expression in a number of proto-oncogenes (c-Neu, Cyclin D1, p27, cell status markers (Met-1, CK19, and the inflammatory marker NFκB. Previous studies, have demonstrated the role of these markers as evidence of malignant transformations, and further illustrate the ability of β-HCH to be carcinogenic. To demonstrate β-HCH's tumorigenic properties in an in vivo system, we used an MMTV-Neu mouse model. MMTV-Neu is a c-Neu overexpressing strain which has been shown to spontaneously develop mammary tumors at later stages of aging. In this experiment,

  19. No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer

    DEFF Research Database (Denmark)

    Cramer, Elisabeth P; Glenthøj, Andreas; Häger, Mattias

    2012-01-01

    expression in tumors of MMTV-PyMT-positive and wild-type mice was assessed by quantitative real-time PCR and by immunohistochemistry. The expression of the lipocalin-2 receptors 24p3R and megalin and of Mmp-9, transferrin receptor, and Bdh2 (a producer of a mammalian siderophore) were quantitated by real......NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of breast cancer as determined both in patients and in mouse breast cancer...... models. This was recently confirmed in two mouse models of spontaneous breast cancer in wild-type and lipocalin-2-deficient mice. We used a similar strategy using a different mouse strain. Lipocalin-2-deficient mice and mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice were crossed...

  20. Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

    OpenAIRE

    James S. Lawson; Brian Salmons; Wendy K. Glenn

    2018-01-01

    BackgroundAlthough the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown. The development of substantial recent evidence indicates that a handful of viruses may have a role in breast cancer. These viruses are mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma viruses (HPVs), and Epstein–Barr virus (EBV-al...

  1. Effect of Withania somnifera Root Extract on Spontaneous Estrogen Receptor-Negative Mammary Cancer in MMTV/Neu Mice

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    KHAZAL, KAMEL F.; HILL, DONALD L.; GRUBBS, CLINTON J.

    2015-01-01

    The cancer-preventive activity of an extract of Withania somnifera (WS) roots was examined in female transgenic (MMTV/Neu) mice that received a diet containing the extract (750 mg/kg of diet) for 10 months. Mice in the treated group (N=35) had an average of 1.66 mammary carcinomas, and mice in the control group (N=33) had 2.48, a reduction of 33%. The average weights of the carcinomas were 2.36 g for mice in the treated group and 2.63 g for the controls, a difference of 10%. Labeling indices for Ki67 and proliferating cell nuclear antigen marker in mammary carcinomas of the treated group were 35% and 30% lower, respectively, than those of the corresponding control group. Expression of the chemokine was reduced by 50%. These results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas. PMID:25368231

  2. Treatment response assessment with (R)-[11CPAQ PET in the MMTV-PyMT mouse model of breast cancer.

    Science.gov (United States)

    Tegnebratt, T; Lu, L; Eksborg, S; Chireh, A; Damberg, P; Nikkhou-Aski, S; Foukakis, T; Rundqvist, H; Holmin, S; Kuiper, R V; Samen, E

    2018-04-03

    The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methoxy)-4-quinazolineamine ((R)-[ 11 C]PAQ) as a positron emission tomography (PET) imaging biomarker for evaluation of the efficacy of anticancer drugs in preclinical models. MMTV-PyMT mice were treated with vehicle alone (VEH), murine anti-VEGFA antibody (B20-4.1.1), and paclitaxel (PTX) in combination or as single agents. The treatment response was measured with (R)-[ 11 C]PAQ PET as standardized uptake value (SUV) mean , SUV max relative changes at the baseline (day 0) and follow-up (day 4) time points, and magnetic resonance imaging (MRI)-derived PyMT mammary tumor volume (TV) changes. Expression of Ki67, VEGFR-2, and CD31 in tumor tissue was determined by immunohistochemistry (IHC). Non-parametric statistical tests were used to evaluate the relation between (R)-[ 11 C]PAQ radiotracer uptake and therapy response biomarkers. The (R)-[ 11 C]PAQ SUV max in tumors was significantly reduced after 4 days in the B20-4.1.1/PTX combinational and B20-4.1.1 monotherapy groups (p PAQ SUV max change and TV reduction in the B20-4.1.1/PTX group. Statistical testing showed a significant difference in the blood vessel density between the B20-4.1.1/PTX combinational group and the VEH group (p PAQ can be approved as a predictive radiotracer for cancer therapy response.

  3. Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice.

    Science.gov (United States)

    Ma, Zhikun; Parris, Amanda B; Xiao, Zhengzheng; Howard, Erin W; Kosanke, Stanley D; Feng, Xiaoshan; Yang, Xiaohe

    2017-01-06

    Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER + breast cancers, prevention of hormone receptor-negative breast cancers, such as Her2/erbB-2 + breast cancers, remains a significant issue. Previous studies have demonstrated that administration of EGFR/erbB-2-targeting lapatinib to MMTV-erbB-2 transgenic mice inhibited mammary tumor development. The prevention, however, was achieved by prolonged high dose exposure. The tolerance to high dose/long-term drug administration may hinder its potential in clinical settings. Therefore, we aimed to test a novel, short-term chemopreventative strategy using lapatinib during the premalignant risk window in MMTV-erbB-2 mice. We initially treated cultured cells with lapatinib to explore the anti-proliferative effects of lapatinib in vitro. We used a syngeneic tumor graft model to begin exploring the in vivo anti-tumorigenic effects of lapatinib in MMTV-erbB-2 mice. Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice. In the syngeneic tumor transplant model, we determined that lapatinib significantly inhibited tumor cell proliferation. Furthermore, we demonstrated that short-term lapatinib exposure resulted in life-long protective effects, as supported by increased tumor latency in lapatinib-treated mice compared to the control mice. We further established that delayed tumor development in the treated mice was preceded by decreased BrdU nuclear incorporation and inhibited mammary morphogenesis. Molecular analysis indicated that lapatinib inhibited phosphorylation and expression of EGFR, erbB-3, erbB-2, Akt1, and Erk1/2 in premalignant mammary tissues. Also, lapatinib drastically inhibited the phosphorylation and expression of ERα and the transcription of ER target genes in premalignant mammary tissues. We also determined that

  4. Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary rimor development in Tg.NK (MMTV/c-neu) mice

    DEFF Research Database (Denmark)

    Luijten, M.; Thomsen, A.R.; van den Berg, J.A.H.

    2004-01-01

    Phytoestrogens such as isoflavonoids and lignans have been postulated as breast cancer protective constituents in soy and whole-grain cereals. We investigated the ability of isoflavones (IFs) and flaxseed to modulate spontaneous mammary tumor development in female heterozygous Tg.NK (MMTV....../c-neu) mice. Two different exposure protocols were applied, either from 4 wk of age onward (postweaning) or during gestation and lactation (perinatal). In the postweaning exposure study, mice were fed IFs or flaxseed in a high-fat diet. In addition, flaxseed in a low-fat diet was tested. Postweaning exposure...... to IFs and flaxseed tended to accelerate the onset of mammary adenocarcinoma development, although tumor burden at necropsy was not changed significantly. Perinatal IF exposure resulted in enhanced mammary gland differentiation, but palpable mammary tumor onset was not affected. However, tumor burden...

  5. Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV, Bovine Leukemia Virus (BLV, Human Papilloma Virus (HPV, and Epstein–Barr Virus (EBV

    Directory of Open Access Journals (Sweden)

    James S. Lawson

    2018-01-01

    Full Text Available BackgroundAlthough the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown. The development of substantial recent evidence indicates that a handful of viruses may have a role in breast cancer. These viruses are mouse mammary tumor virus (MMTV, bovine leukemia virus (BLV, human papilloma viruses (HPVs, and Epstein–Barr virus (EBV-also known as human herpes virus type 4. Each of these viruses has documented oncogenic potential. The aim of this review is to inform the scientific and general community about this recent evidence.The evidenceMMTV and human breast cancer—the evidence is detailed and comprehensive but cannot be regarded as conclusive. BLV and human breast cancer—the evidence is limited. However, in view of the emerging information about BLV in human breast cancer, it is prudent to encourage the elimination of BLV in cattle, particularly in the dairy industry. HPVs and breast cancer—the evidence is substantial but not conclusive. The availability of effective preventive vaccines is a major advantage and their use should be encouraged. EBV and breast cancer—the evidence is also substantial but not conclusive. Currently, there are no practical means of either prevention or treatment. Although there is evidence of genetic predisposition, and cancer in general is a culmination of events, there is no evidence that inherited genetic traits are causal.ConclusionThe influence of oncogenic viruses is currently the major plausible hypothesis for a direct cause of human breast cancer.

  6. GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

    International Nuclear Information System (INIS)

    Lynn, Kristi D; Udugamasooriya, D Gomika; Roland, Christina L; Castrillon, Diego H; Kodadek, Thomas J; Brekken, Rolf A

    2010-01-01

    Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis under physiological and pathological conditions. Anti-VEGF therapy is a clinically proven strategy for the treatment of a variety of cancers including colon, breast, lung, and renal cell carcinoma. Since VEGFR2 is the dominant angiogenic signaling receptor, it has become an important target in the development of novel anti-angiogenic therapies. We have reported previously the development of an antagonistic VEGFR2 peptoid (GU40C4) that has promising anti-angiogenic activity in vitro and in vivo. In the current study, we utilize a derivative of GU40C4, termed GU81 in therapy studies. GU81 was tested alone or in combination with doxorubicin for in vivo efficacy in the MMTV-PyMT transgenic model of breast cancer. The derivative GU81 has increased in vitro efficacy compared to GU40C4. Single agent therapy (doxorubicin or GU81 alone) had no effect on tumor weight, histology, tumor fat content, or tumor growth index. However, GU81 is able to significantly to reduce total vascular area as a single agent. GU81 used in combination with doxorubicin significantly reduced tumor weight and growth index compared to all other treatment groups. Furthermore, treatment with combination therapy significantly arrested tumor progression at the premalignant stage, resulting in increased tumor fat content. Interestingly, treatment with GU81 alone increased tumor-VEGF levels and macrophage infiltration, an effect that was abrogated when used in combination with doxorubicin. This study demonstrates the VEGFR2 antagonist peptoid, GU81, enhances the anti-tumor activity of doxorubicin in spontaneous murine MMTV-PyMT breast tumors

  7. Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein-Barr Virus (EBV).

    Science.gov (United States)

    Lawson, James S; Salmons, Brian; Glenn, Wendy K

    2018-01-01

    Although the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown. The development of substantial recent evidence indicates that a handful of viruses may have a role in breast cancer. These viruses are mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma viruses (HPVs), and Epstein-Barr virus (EBV-also known as human herpes virus type 4). Each of these viruses has documented oncogenic potential. The aim of this review is to inform the scientific and general community about this recent evidence. MMTV and human breast cancer-the evidence is detailed and comprehensive but cannot be regarded as conclusive. BLV and human breast cancer-the evidence is limited. However, in view of the emerging information about BLV in human breast cancer, it is prudent to encourage the elimination of BLV in cattle, particularly in the dairy industry. HPVs and breast cancer-the evidence is substantial but not conclusive. The availability of effective preventive vaccines is a major advantage and their use should be encouraged. EBV and breast cancer-the evidence is also substantial but not conclusive. Currently, there are no practical means of either prevention or treatment. Although there is evidence of genetic predisposition, and cancer in general is a culmination of events, there is no evidence that inherited genetic traits are causal. The influence of oncogenic viruses is currently the major plausible hypothesis for a direct cause of human breast cancer.

  8. Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis

    Science.gov (United States)

    Ye, Xiaoqian; Attaie, Ali B.

    2016-01-01

    Human dentition development is a long and complex process which involves a series of reciprocal and sequential interactions between the embryonic stomodeal epithelium and the underlying neural crest–derived mesenchyme. Despite environment disturbances, tooth development is predominantly genetically controlled. To date, more than 200 genes have been identified in tooth development. These genes implied in various signaling pathways such as the bone morphogenetic protein, fibroblast growth factor, sonic hedgehog homolog, ectodysplasin A, wingless-type MMTV integration site family (Wnt), and transform growth factor pathways. Mutations in any of these strictly balanced signaling cascades may cause arrested odontogenesis and/or other dental defects. This article aims to review current knowledge about the genetic mechanisms responsible for selective nonsyndromic tooth agenesis in humans and to present a detailed summary of syndromes with hypodontia as regular features and their causative genes. PMID:27895972

  9. Microgenomics of Ameloblastoma

    Science.gov (United States)

    DeVilliers, P.; Suggs, C.; Simmons, D.; Murrah, V.; Wright, J.T.

    2011-01-01

    Gene expression profiles of human ameloblastoma microdissected cells were characterized with the purpose of identifying genes and their protein products that could be targeted as diagnostic and prognostic markers as well as for potential therapeutic interventions. Five formalin-fixed, decalcified, paraffin-embedded samples of ameloblastoma were subjected to laser capture microdissection, linear mRNA amplification, and hybridization to oligonucleotide human 41,000 RNA arrays and compared with universal human reference RNA, to determine the gene expression signature. Assessment of the data by Significance Analysis of Microarrays (SAM) and cluster analysis showed that 38 genes were highly expressed (two-fold increase) in all samples, while 41 genes were underexpressed (two-fold reduction). Elements of the sonic hedgehog pathway and Wingless type MMTV integration site family were validated by immunohistochemistry. We have identified the expression of multiple genes and protein products that could serve as potential diagnostic, prognostic, and therapeutic targets. PMID:21282726

  10. High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer

    Directory of Open Access Journals (Sweden)

    Sarah Cowen

    2015-06-01

    Full Text Available Epidemiological studies provide strong evidence that obesity and the associated adipose tissue inflammation are risk factors for breast cancer; however, the molecular mechanisms are poorly understood. We evaluated the effect of a high-fat/high-calorie diet on mammary carcinogenesis in the immunocompetent MMTV-PyMT murine model. Four-week old female mice (20/group were randomized to receive either a high-fat (HF; 60% kcal as fat or a low-fat (LF; 16% kcal diet for eight weeks. Body weights were determined, and tumor volumes measured by ultrasound, each week. At necropsy, the tumors and abdominal visceral fat were weighed and plasma collected. The primary mammary tumors, adjacent mammary fat, and lungs were preserved for histological and immunohistochemical examination and quantification of infiltrating macrophages, crown-like structure (CLS formation, and microvessel density. The body weight gains, visceral fat weights, the primary mammary tumor growth rates and terminal weights, were all significantly greater in the HF-fed mice. Adipose tissue inflammation in the HF group was indicated by hepatic steatosis, pronounced macrophage infiltration and CLS formation, and elevations in plasma monocyte chemoattractant protein-1 (MCP-1, leptin and proinflammatory cytokine concentrations. HF intake was also associated with higher tumor-associated microvascular density and the proangiogenic factor MCP-1. This study provides preclinical evidence in a spontaneous model of breast cancer that mammary adipose tissue inflammation induced by diet, enhances the recruitment of macrophages and increases tumor vascular density suggesting a role for obesity in creating a microenvironment favorable for angiogenesis in the progression of breast cancer.

  11. High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cowen, Sarah [Department of Surgery, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); McLaughlin, Sarah L. [Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Hobbs, Gerald [Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Department of Statistics, West Virginia University, Morgantown, WV 26506 (United States); Coad, James [Department of Pathology, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Martin, Karen H. [Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Department of Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Olfert, I. Mark [Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Department of Human Performance and Exercise Physiology, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Vona-Davis, Linda, E-mail: lvdavis@hsc.wvu.edu [Department of Surgery, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States); Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 (United States)

    2015-06-26

    Epidemiological studies provide strong evidence that obesity and the associated adipose tissue inflammation are risk factors for breast cancer; however, the molecular mechanisms are poorly understood. We evaluated the effect of a high-fat/high-calorie diet on mammary carcinogenesis in the immunocompetent MMTV-PyMT murine model. Four-week old female mice (20/group) were randomized to receive either a high-fat (HF; 60% kcal as fat) or a low-fat (LF; 16% kcal) diet for eight weeks. Body weights were determined, and tumor volumes measured by ultrasound, each week. At necropsy, the tumors and abdominal visceral fat were weighed and plasma collected. The primary mammary tumors, adjacent mammary fat, and lungs were preserved for histological and immunohistochemical examination and quantification of infiltrating macrophages, crown-like structure (CLS) formation, and microvessel density. The body weight gains, visceral fat weights, the primary mammary tumor growth rates and terminal weights, were all significantly greater in the HF-fed mice. Adipose tissue inflammation in the HF group was indicated by hepatic steatosis, pronounced macrophage infiltration and CLS formation, and elevations in plasma monocyte chemoattractant protein-1 (MCP-1), leptin and proinflammatory cytokine concentrations. HF intake was also associated with higher tumor-associated microvascular density and the proangiogenic factor MCP-1. This study provides preclinical evidence in a spontaneous model of breast cancer that mammary adipose tissue inflammation induced by diet, enhances the recruitment of macrophages and increases tumor vascular density suggesting a role for obesity in creating a microenvironment favorable for angiogenesis in the progression of breast cancer.

  12. Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13C]pyruvate

    DEFF Research Database (Denmark)

    Asghar Butt, Sadia; Søgaard, Lise V.; Ardenkjær-Larsen, Jan Henrik

    2015-01-01

    Purpose: To use dynamic magnetic resonance spectroscopy (MRS) of hyperpolarized 13C-pyruvate to follow the progress over time in vivo of breast cancer metabolism in the MMTV-PymT model, and to follow the response to the anti-estrogen drug tamoxifen. Methods: Tumor growth was monitored by anatomical...... significantly in the treated group. Conclusion: These hyperpolarized 13C MRS findings indicate that tumor metabolic changes affects kP. The measured kp did not relate to treatment response to the same extent as did tumor growth, histological evaluation, and in vitro determination of LDH activity. © 2014 Wiley...

  13. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  14. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    , while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...

  15. Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

    Science.gov (United States)

    Rodrigues, Loreta M; Chung, Yuen-Li; Al Saffar, Nada M S; Sharp, Swee Y; Jackson, Laura E; Banerji, Udai; Stubbs, Marion; Leach, Martin O; Griffiths, John R; Workman, Paul

    2012-05-23

    The importance of ERBB2/NEU/HER2 in the response of breast tumours to the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG; tanespimycin) has been demonstrated in the clinic. ERBB2 is an oncoprotein client that is highly dependent on HSP90. This and other oncogenic client proteins (e.g. B-RAF, C-RAF, ALK and CDK4) are depleted by 17-AAG in both animal tumours and patients. Here we investigate by Magnetic Resonance Spectroscopy (MRS) the metabolic response of 17-AAG in spontaneous, NEU/HER2 driven mammary tumours in transgenic MMTV-NEU-NT mice and in cells isolated and cultured from these tumours. Mammary tumours were monitored by 31P MRS in vivo and in tumour extracts, comparing control and 17-AAG treated mice. A cell line derived from NEU/HER2 mammary tumours was also cultured and the effect of 17-AAG was measured by 31P MRS in cell extracts. Molecular biomarkers were assessed by immunoblotting in extracts from cells and tumours. For comparison of tumour volume, metabolite concentrations and Western blot band intensities, two-tailed unpaired t-tests were used. The NEU/HER2 mammary tumours were very sensitive to 17-AAG and responded in a dose-dependent manner to 3 daily doses of 20, 40 and 80mg/kg of 17-AAG, all of which caused significant regression. At the higher doses, 31P MRS of tumour extracts showed significant decreases in phosphocholine (PC) and phosphoethanolamine (PE) whereas no significant changes were seen at the 20mg/kg dose. Extracts of isolated cells cultured from the mammary carcinomas showed a significant decrease in viable cell number and total PME after 17-AAG treatment. Western blots confirmed the expected action of 17-AAG in inducing HSP72 and significantly depleting HSP90 client proteins, including NEU/HER2 both in tumours and in isolated cells. The data demonstrate the high degree of sensitivity of this clinically relevant NEU/HER2-driven tumour model to HSP90 inhibition by 17-AAG, consistent with the

  16. WNT10A coding variants and maxillary lateral incisor agenesis with associated dental anomalies.

    Science.gov (United States)

    Mostowska, Adrianna; Biedziak, Barbara; Zadurska, Małgorzata; Matuszewska-Trojan, Sylwia; Jagodziński, Paweł P

    2015-02-01

    Congenital maxillary lateral incisor agenesis (MLIA) is one of the most common subtypes of dental agenesis. Because little is known with regard to the aetiology of this anomaly, the aim of the study was to determine the contribution of nucleotide variants in wingless-type MMTV integration site family, member 10A (WNT10A), msh homeobox 1 (MSX1), and paired box 9 (PAX9) to the risk of MLIA in a Polish population. Coding regions of the selected genes were analysed by direct sequencing in a group of 20 individuals with unilateral and bilateral MLIA, associated or not with other dental anomalies. The frequencies of the identified nucleotide variants were assessed in an additional cohort of patients with isolated dental agenesis (n = 147) and in 178 controls. Mutation screening showed four non-synonymous substitutions located in the highly conserved coding sequence of WNT10A in five (25%) of the 20 patients. Analysis of genotyping results revealed that three of these variants--p.Arg113Cys, p.Phe228Ile, and the newly identified p.Arg171Leu--may represent aetiological mutations underlying MLIA with associated dental anomalies. No mutations that were potentially aetiologic were identified in MSX1 and PAX9. In conclusion, this is the first report implicating coding variants in the WNT10A gene in the aetiology of MLIA. These results will require further confirmation using larger-scale studies. © 2014 Eur J Oral Sci.

  17. Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression.

    Science.gov (United States)

    Zhong, Leilei; Schivo, Stefano; Huang, Xiaobin; Leijten, Jeroen; Karperien, Marcel; Post, Janine N

    2017-11-22

    Interleukin 1 beta (IL1β) and Wingless-Type MMTV Integration Site Family (WNT) signaling are major players in Osteoarthritis (OA) pathogenesis. Despite having a large functional overlap in OA onset and development, the mechanism of IL1β and WNT crosstalk has remained largely unknown. In this study, we have used a combination of computational modeling and molecular biology to reveal direct or indirect crosstalk between these pathways. Specifically, we revealed a mechanism by which IL1β upregulates WNT signaling via downregulating WNT antagonists, DKK1 and FRZB. In human chondrocytes, IL1β decreased the expression of Dickkopf-1 (DKK1) and Frizzled related protein (FRZB) through upregulation of nitric oxide synthase (iNOS), thereby activating the transcription of WNT target genes. This effect could be reversed by iNOS inhibitor 1400W, which restored DKK1 and FRZB expression and their inhibitory effect on WNT signaling. In addition, 1400W also inhibited both the matrix metalloproteinase (MMP) expression and cytokine-induced apoptosis. We concluded that iNOS/NO play a pivotal role in the inflammatory response of human OA through indirect upregulation of WNT signaling. Blocking NO production may inhibit the loss of the articular phenotype in OA by preventing downregulation of the expression of DKK1 and FRZB.

  18. Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation.

    Directory of Open Access Journals (Sweden)

    Katharina Felber

    Full Text Available Osteoblast differentiation from mesenchymal cells is regulated by multiple signalling pathways. Here we have analysed the roles of Fibroblast Growth Factor (FGF and canonical Wingless-type MMTV integration site (Wnt/β-Catenin signalling pathways on zebrafish osteogenesis. We have used transgenic and chemical interference approaches to manipulate these pathways and have found that both pathways are required for osteoblast differentiation in vivo. Our analysis of bone markers suggests that these pathways act at the same stage of differentiation to initiate expression of the osteoblast master regulatory gene osterix (osx. We use two independent approaches that suggest that osx is a direct target of these pathways. Firstly, we manipulate signalling and show that osx gene expression responds with similar kinetics to that of known transcriptional targets of the FGF and Wnt pathways. Secondly, we have performed ChIP with transcription factors for both pathways and our data suggest that a genomic region in the first intron of osx mediates transcriptional activation. Based upon these data, we propose that FGF and Wnt/β-Catenin pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.

  19. Dickkopf-related protein 1 inhibits the WNT signaling pathway and improves pig oocyte maturation.

    Directory of Open Access Journals (Sweden)

    Lee D Spate

    Full Text Available The ability to mature oocytes in vitro provides a tool for creating embryos by parthenogenesis, fertilization, and cloning. Unfortunately the quality of oocytes matured in vitro falls behind that of in vivo matured oocytes. To address this difference, transcriptional profiling by deep sequencing was conducted on pig oocytes that were either matured in vitro or in vivo. Alignment of over 18 million reads identified 1,316 transcripts that were differentially represented. One pathway that was overrepresented in the oocytes matured in vitro was for Wingless-type MMTV integration site (WNT signaling. In an attempt to inhibit the WNT pathway, Dickkopf-related protein 1 was added to the in vitro maturation medium. Addition of Dickkopf-related protein 1 improved the percentage of oocytes that matured to the metaphase II stage, increased the number of nuclei in the resulting blastocyst stage embryos, and reduced the amount of disheveled segment polarity protein 1 protein in oocytes. It is concluded that transcriptional profiling is a powerful method for detecting differences between in vitro and in vivo matured oocytes, and that the WNT signaling pathway is important for proper oocyte maturation.

  20. Development of a Rapid Salivary Proteomic Platform for Oral Feeding Readiness in the Preterm Newborn

    Directory of Open Access Journals (Sweden)

    Prarthana Khanna

    2017-12-01

    Full Text Available Oral feeding competency is a major determinant of length of stay in the neonatal intensive care unit. An infant must be able to consistently demonstrate the ability to take all required enteral nutrition by mouth before discharge home. Most infants born prematurely (<37 weeks will require days, if not weeks, to master this oral feeding competency skill. Inappropriately timed feeding attempts can lead to acute and long-term morbidities, prolonged hospitalizations, and increased health-care costs. Previously, a panel of five genes involved in essential developmental pathways including sensory integration (nephronophthisis 4, Plexin A1, hunger signaling [neuropeptide Y2 receptor (NPY2R, adenosine-monophosphate-activated protein kinase (AMPK], and facial development (wingless-type MMTV integration site family, member 3 required for oral feeding success were identified in neonatal saliva. This study aimed to translate these five transcriptomic biomarkers into a rapid proteomic platform to provide objective, real-time assessment of oral feeding skills, to better inform care, and to improve neonatal outcomes. Total protein was extracted from saliva of 10 feeding-successful and 10 feeding-unsuccessful infants matched for age, sex, and post-conceptional age. Development of immunoassays was attempted for five oral feeding biomarkers and two reference biomarkers (GAPDH and YWHAZ to normalize for starting protein concentrations. Normalized protein concentrations were correlated to both feeding status at time of sample collection and previously described gene expression profiles. Only the reference proteins and those involved in hunger signaling were detected in neonatal saliva at measurable levels. Expression patterns for NPY2R and AMPK correlated with the gene expression patterns previously seen between successful and unsuccessful feeders and predicted feeding outcome. Salivary proteins associated with hunger signaling are readily quantifiable in

  1. Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

    Directory of Open Access Journals (Sweden)

    Komaraiah Palle

    2015-11-01

    Full Text Available The canonical hedgehog (HH pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1, smoothened (SMO that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1, GLI2 and GLI3. Activation of GLIs must be tightly regulated as they modulate target genes which control tissue patterning, stem cell maintenance, and differentiation during development. However, dysregulation or mutations in HH signaling leads to genomic instability (GI and various cancers, for example, germline mutation in PTCH1 lead to Gorlin syndrome, a condition where patients develop numerous basal cell carcinomas and rarely rhabdomyosarcoma (RMS. Activating mutations in SMO have also been recognized in sporadic cases of medulloblastoma and SMO is overexpressed in many other cancers. Recently, studies in several human cancers have shown that GLI1 expression is independent from HH ligand and canonical intracellular signaling through PTCH and SMO. In fact, this aberrantly regulated GLI1 has been linked to several non-canonical oncogenic growth signals such as Kirsten rat sarcoma viral oncogene homolog (KRAS, avian myelocytomatosis virus oncogene cellular homolog (C-MYC, transforming growth factor β (TGFβ, wingless-type MMTV integration site family (WNT and β-catenin. Recent studies from our lab and other independent studies demonstrate that aberrantly expressed GLI1 influences the integrity of several DNA damage response and repair signals, and if altered, these networks can contribute to GI and impact tumor response to chemo- and radiation therapies. Furthermore, the ineffectiveness of SMO inhibitors in clinical studies argues for the development of GLI1-specific inhibitors in order to develop effective therapeutic modalities to treat these tumors. In this review, we focus on summarizing current understanding of the molecular, biochemical and cellular basis

  2. Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis

    Science.gov (United States)

    Liu, Yang; Liu, Haochen; Zhao, Hongshan; Zhang, Guozhong; Snead, Malcolm L.; Han, Dong; Feng, Hailan

    2016-01-01

    Recent studies have demonstrated that ectodysplasin-A (EDA) mutations are associated with non-syndromic tooth agenesis. Indeed, we were the first to report three novel EDA mutations (A259E, R289C and R334H) in sporadic non-syndromic tooth agenesis. We studied the mechanism linking EDA mutations and non-syndromic tooth agenesis in human embryonic kidney 293T cells and mouse ameloblast-derived LS8 cells transfected with mutant isoforms of EDA. The receptor binding capability of the mutant EDA1 protein was impaired in comparison to wild-type EDA1. Although the non-syndromic tooth agenesis-causing EDA1 mutants possessed residual binding capability, the transcriptional activation of the receptor’s downstream target, nuclear factor κB (NF-κB), was compromised. We also analyzed the changes of selected genes in other signaling pathways, such as WNT and BMP, after EDA mutation. We found that non-syndromic tooth agenesis-causing EDA1 mutant proteins upregulate BMP4 (bone morphogenetic protein 4) mRNA expression and downregulate WNT10A and WNT10B (wingless-type MMTV integration site family member 10A and 10B) mRNA expression. Our results indicated that non-syndromic tooth agenesis causing EDA mutations (A259E, R289C and R334H) were loss-of-function, and suggested that EDA may regulate the expression of WNT10A, WNT10B and BMP4 via NF-κB during tooth development. The results from our study may help to understand the molecular mechanism linking specific EDA mutations with non-syndromic tooth agenesis. PMID:27144394

  3. Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation.

    Science.gov (United States)

    Marini, Joan C; Reich, Adi; Smith, Simone M

    2014-08-01

    Osteogenesis imperfecta or 'brittle bone disease' has mainly been considered a bone disorder caused by collagen mutations. Within the last decade, however, a surge of genetic discoveries has created a new paradigm for osteogenesis imperfecta as a collagen-related disorder, where most cases are due to autosomal dominant type I collagen defects, while rare, mostly recessive, forms are due to defects in genes whose protein products interact with collagen protein. This review is both timely and relevant in outlining the genesis, development, and future of this paradigm shift in the understanding of osteogenesis imperfecta. Bone-restricted interferon-induced transmembrane (IFITM)-like protein (BRIL) and pigment epithelium-derived factor (PEDF) defects cause types V and VI osteogenesis imperfecta via defective bone mineralization, while defects in cartilage-associated protein (CRTAP), prolyl 3-hydroxylase 1 (P3H1), and cyclophilin B (CYPB) cause types VII-IX osteogenesis imperfecta via defective collagen post-translational modification. Heat shock protein 47 (HSP47) and FK506-binding protein-65 (FKBP65) defects cause types X and XI osteogenesis imperfecta via aberrant collagen crosslinking, folding, and chaperoning, while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specifically induced substance (OASIS) disrupt osteoblast development. Finally, absence of the type I collagen C-propeptidase bone morphogenetic protein 1 (BMP1) causes type XII osteogenesis imperfecta due to altered collagen maturation/processing. Identification of these multiple causative defects has provided crucial information for accurate genetic counseling, inspired a recently proposed functional grouping of osteogenesis imperfecta types by shared mechanism to simplify current nosology, and has prodded investigations into common pathways in osteogenesis imperfecta. Such

  4. Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells.

    Science.gov (United States)

    Wang, Yan; Wang, Zunsong; Li, Hong; Xu, Wenwei; Dong, Lin; Guo, Yan; Feng, Saran; Bi, Kehong; Zhu, Chuansheng

    2017-05-01

    The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As 2 O 3 ) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells. Methylation-specific polymerase chain reaction was used to examine the CpG island methylation status of the SFRP1 gene in leukemia cell lines. In addition, the effects on Jurkat cells of treatment with different concentrations of As 2 O 3 for 48 h were investigated. Reverse transcription-quantitative polymerase chain reaction was employed to measure the expression of mRNAs, while western blot analysis was used to examine protein expression in cells. The SFRP1 gene was methylated in Jurkat cells. However, both methylated and unmethylated SFRP1 genes were detected in HL60 and K562 cells. In normal bone marrow mononuclear cells, the SFRP1 gene was unmethylated. Following treatment with As 2 O 3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased. By contrast, the mRNA and protein expression levels of β-catenin and cyclin Dl were downregulated. The protein expression of c-myc was also downregulated, but As 2 O 3 exhibited no significant effect on the mRNA expression of c-myc. Abnormal methylation of the SFRP1 gene was detected in Jurkat cells. These results suggest that As 2 O 3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene. Furthermore, they indicate that As 2 O 3 regulates WNT target genes and controls the growth of Jurkat cells through the WNT/β-catenin signaling pathway.

  5. MGST2 and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients

    Directory of Open Access Journals (Sweden)

    Jingjing Zhang

    2017-10-01

    Full Text Available Background/Aim Strabismus is a common condition with misalignment between two eyes that may lead to decrease of visual acuity, lack of binocularity, and diplopia. It is caused by heterogeneous environmental and genetic risk factors. Our previous research has identified new chromosomal susceptibility loci in 4q28.3 and 7q31.2 regions for comitant strabismus in Japanese families. We conducted a verification study by linkage analysis to narrow the chromosomal loci down to a single gene. Methods From Japanese and U.S. databases, 24 rsSNPs and 233 rsSNPs were chosen from the 4q28.3 and 7q31.2 region, respectively, and were typed in 108 affected subjects and 96 unaffected subjects of 58 families with primary and non-syndromic comitant strabismus. Three major analytical methods were used: transmission disequilibrium test (TDT, TDT allowing for errors (TDTae, and linkage analysis under dominant and recessive inheritance. Results The SNPs with significant P values in TDT and TDTae were located solely at the gene, microsomal glutathione S-transferase 2 (MGST2, on chromosome 4q28.3 locus. In contrast, significant SNPs were dispersed in a few genes, containing wingless-type MMTV integration site family member 2 (WNT2, on chromosome 7q31.2 locus. The distribution of significant SNPs on the 7q31.2 locus showed that only the ST7 to WNT2 region in the same big haplotype block contained significant SNPs for all three methods of linkage analysis. Conclusions This study suggests that MGST2 and WNT2 are potential candidates for comitant strabismus in Japanese population.

  6. Avian WNT4 in the female reproductive tracts: potential role of oviduct development and ovarian carcinogenesis.

    Directory of Open Access Journals (Sweden)

    Chul-Hong Lim

    Full Text Available The wingless-type MMTV integration site family of proteins (WNTs is highly conserved secreted lipid-modified signaling molecules that play a variety of pivotal roles in developmental events such as embryogenesis, tissue homeostasis and cell polarity. Although, of these proteins, WNT4 is known to be involved in genital development in fetuses of mammalian species, its role is unknown in avian species. Therefore, in this study, we investigated expression profiles, as well as hormonal and post-transcriptional regulation of WNT4 expression in the reproductive tract of female chickens. Results of this study demonstrated that WNT4 is most abundant in the stromal and luminal epithelial cells of the isthmus and shell gland of the oviduct, respectively. WNT4 is also most abundant in the glandular epithelium of the shell gland of the oviduct of laying hens at 3 h post-ovulation during the laying cycle. In addition, treatment of young chicks with diethylstilbestrol (DES, a synthetic estrogen agonist stimulated WNT4 only in the glandular epithelial cells of the isthmus and shell gland of the oviduct. Moreover, results of our study demonstrated that miR-1786 influences WNT4 expression via specific binding sites in its 3'-UTR. On the other hand, our results also indicate that WNT4 is expressed predominantly in the glandular epithelium of cancerous ovaries, but not in normal ovaries of hens. Collectively, these results indicate cell-specific expression of WNT4 in the reproductive tract of chickens and that it likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens.

  7. Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

    International Nuclear Information System (INIS)

    Perkins, Timothy N.; Dentener, Mieke A.; Stassen, Frank R.; Rohde, Gernot G.; Mossman, Brooke T.; Wouters, Emiel F.M.; Reynaert, Niki L.

    2016-01-01

    Growth and development of the mature lung is a complex process orchestrated by a number of intricate developmental signaling pathways. Wingless-type MMTV-integration site (WNT) signaling plays critical roles in controlling branching morphogenesis cell differentiation, and formation of the conducting and respiratory airways. In addition, WNT pathways are often re-activated in mature lungs during repair and regeneration. WNT- signaling has been elucidated as a crucial contributor to the development of idiopathic pulmonary fibrosis as well as other hyper-proliferative lung diseases. Silicosis, a detrimental occupational lung disease caused by excessive inhalation of crystalline silica dust, is hallmarked by repeated cycles of damaging inflammation, epithelial hyperplasia, and formation of dense, hyalinized nodules of whorled collagen. However, mechanisms of epithelial cell hyperplasia and matrix deposition are not well understood, as most research efforts have focused on the pronounced inflammatory response. Microarray data from our previous studies has revealed a number of WNT-signaling and WNT-target genes altered by crystalline silica in human lung epithelial cells. In the present study, we utilize pathway analysis to designate connections between genes altered by silica in WNT-signaling networks. Furthermore, we confirm microarray findings by QRT-PCR and demonstrate both activation of canonical (β-catenin) and down-regulation of non-canonical (WNT5A) signaling in immortalized (BEAS-2B) and primary (PBEC) human bronchial epithelial cells. These findings suggest that WNT-signaling and cross-talk with other pathways (e.g. Notch), may contribute to proliferative, fibrogenic and inflammatory responses to silica in lung epithelial cells. - Highlights: • Pathway analysis reveals silica-induced WNT-signaling in lung epithelial cells. • Silica-induced canonical WNT-signaling is mediated by autocrine/paracrine signals. • Crystalline silica decreases non-canonical WNT

  8. PCBs Exert an Estrogenic Effect through Repression of the Wnt7a Signaling Pathway in the Female Reproductive Tract

    Science.gov (United States)

    Ma, Risheng; Sassoon, David A.

    2006-01-01

    Polychlorinated biphenyls (PCBs) have been proposed to have a weak estrogenic activity and therefore pose a risk as potential environmental endocrine disruptors to the perinatal development of the female reproductive tract. Perinatal exposure to high concentrations of the potent synthetic estrogen diethylstilbestrol (DES) induces abnormal development of the female reproductive tract via a mechanism that acts through the down-regulation of Wnt7a (wingless-type MMTV integration site family, member 7A). To test the hypothesis that PCBs act as weak estrogens, we injected neonatal mice with a commercial PCB mixture (Aroclor 1254) or with low levels of DES and measured effects of exposure on Wnt7a expression and uterine morphology. We report here that neonatal PCB or low-level DES exposure resulted in the down-regulation of Wnt7a expression. In addition, both PCB and low-level DES exposure induced changes in the uterine myometrium and gland formation. These data reveal that weak estrogens such as the PCBs act through a Wnt7a-dependent pathway and suggest that Wnt7a regulation is a sensitive biomarker for testing weak estrogenic candidate compounds. The morphologic changes that were elicited by PCBs and DES were different immediately after exposure, suggesting that Wnt7a-independent pathways are also activated by one or both of these compounds. Although Wnt7a down-regulation is transient after estrogenic exposure, subsequent morphologic changes became more pronounced during postnatal and adult life, suggesting that the female reproductive tract is permanently reprogrammed after exposure even to weak estrogenic compounds. In addition, Wnt7a heterozygous mice were more sensitive to PCB exposure, revealing an important genetic predisposition to risks of environmental endocrine disruptors. PMID:16759992

  9. Exploiting Heparan Sulfate Proteoglycans in Human Neurogenesis—Controlling Lineage Specification and Fate

    Directory of Open Access Journals (Sweden)

    Chieh Yu

    2017-10-01

    Full Text Available Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential. Stem cell therapies through replenishing damaged or lost cells in the injured area is an attractive treatment of brain trauma and neurodegenerative neurological disorders. Several stem cell types have neurogenic potential including neural stem cells (NSCs, embryonic stem cells (ESCs, induced pluripotent stem cells (iPSCs, and mesenchymal stem cells (MSCs. Currently, effective use of these cells is limited by our lack of understanding and ability to direct lineage commitment and differentiation of neural lineages. Heparan sulfate proteoglycans (HSPGs are ubiquitous proteins within the stem cell microenvironment or niche and are found localized on the cell surface and in the extracellular matrix (ECM, where they interact with numerous signaling molecules. The glycosaminoglycan (GAG chains carried by HSPGs are heterogeneous carbohydrates comprised of repeating disaccharides with specific sulfation patterns that govern ligand interactions to numerous factors including the fibroblast growth factors (FGFs and wingless-type MMTV integration site family (Wnts. As such, HSPGs are plausible targets for guiding and controlling neural stem cell lineage fate. In this review, we provide an overview of HSPG family members syndecans and glypicans, and perlecan and their role in neurogenesis. We summarize the structural changes and subsequent functional implications of heparan sulfate as cells undergo neural lineage differentiation as well as outline the role of HSPG core protein expression throughout mammalian neural development and their function as cell receptors and co-receptors. Finally, we highlight suitable biomimetic approaches for exploiting the role of HSPGs in mammalian neurogenesis to control and tailor cell differentiation into specific lineages. An improved ability to control stem cell specific neural

  10. Different levels of testicular organization during gonadal differentiation in B6.Y(Tir) mice manifesting sex reversal.

    Science.gov (United States)

    Antonio-Rubio, Nivia Rocio; Moreno-Mendoza, Norma

    2012-09-01

    B6.Y(Tir) (mice with Y chromosome from a strain in Tirano, Italy, and autosomes and X-chromosomes from the B6 strain) mice provide an excellent model for analysing sex development that occurs during gonadal differentiation; however, the molecular mechanisms that contribute to sex reversal are unclear. Our aim has been to establish which molecular events participate in this sex reversal. The pattern of gene expression related to testicular [Sry (sex-determining region of the Y chromosome), Sox9 (Sry-related high-mobility group box gene 9) and Mis (Müllerian-inhibiting substance)] and ovarian [Wnt4 (Wingless-type MMTV (murine-mammary-tumour virus) integration site family, member 4), Rspo1 (cysteine-rich secretory protein containing a thrombospondin type 1 repeat) and Stra8 (stimulated by retinoic acid gene 8)] differentiation was analysed by applying immunofluorescence and real-time RT-PCR (reverse transcription-PCR), focusing on XY gonads from the B6.Y(Tir) mouse, but also analysing the normal strains CD-1 and C57BL/6J (B6). The expression of genes related to the process of sexual differentiation was altered in the case of the B6.Y(Tir) strain, both at the transcript and protein level, inducing differentiation of ovaries and ovotestes, but not the formation of the testes, which were normal. Our results indicate that the expression of testicular genes is inhibited at various levels, permitting the expression of ovarian genes such as Wnt4, Stra8 and Rspo1. However, their activity was not clear when the data were averaged. Correlation analysis indicated that an ovary differentiation pathway is activated when the testicular differentiation pathway is inhibited. © The Author(s) Journal compilation © 2012 International Federation for Cell Biology.

  11. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

    Science.gov (United States)

    Wagner, Florence F; Benajiba, Lina; Campbell, Arthur J; Weïwer, Michel; Sacher, Joshua R; Gale, Jennifer P; Ross, Linda; Puissant, Alexandre; Alexe, Gabriela; Conway, Amy; Back, Morgan; Pikman, Yana; Galinsky, Ilene; DeAngelo, Daniel J; Stone, Richard M; Kaya, Taner; Shi, Xi; Robers, Matthew B; Machleidt, Thomas; Wilkinson, Jennifer; Hermine, Olivier; Kung, Andrew; Stein, Adam J; Lakshminarasimhan, Damodharan; Hemann, Michael T; Scolnick, Edward; Zhang, Yan-Ling; Pan, Jen Q; Stegmaier, Kimberly; Holson, Edward B

    2018-03-07

    Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the wingless-type MMTV integration site family (WNT) pathway, is a therapeutic target of interest in many diseases. Although dual GSK3α/β inhibitors have entered clinical trials, none has successfully translated to clinical application. Mechanism-based toxicities, driven in part by the inhibition of both GSK3 paralogs and subsequent β-catenin stabilization, are a concern in the translation of this target class because mutations and overexpression of β-catenin are associated with many cancers. Knockdown of GSK3α or GSK3β individually does not increase β-catenin and offers a conceptual resolution to targeting GSK3: paralog-selective inhibition. However, inadequate chemical tools exist. The design of selective adenosine triphosphate (ATP)-competitive inhibitors poses a drug discovery challenge due to the high homology (95% identity and 100% similarity) in this binding domain. Taking advantage of an Asp 133 →Glu 196 "switch" in their kinase hinge, we present a rational design strategy toward the discovery of paralog-selective GSK3 inhibitors. These GSK3α- and GSK3β-selective inhibitors provide insights into GSK3 targeting in acute myeloid leukemia (AML), where GSK3α was identified as a therapeutic target using genetic approaches. The GSK3α-selective compound BRD0705 inhibits kinase function and does not stabilize β-catenin, mitigating potential neoplastic concerns. BRD0705 induces myeloid differentiation and impairs colony formation in AML cells, with no apparent effect on normal hematopoietic cells. Moreover, BRD0705 impairs leukemia initiation and prolongs survival in AML mouse models. These studies demonstrate feasibility of paralog-selective GSK3α inhibition, offering a promising therapeutic approach in AML. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  12. Avian WNT4 in the female reproductive tracts: potential role of oviduct development and ovarian carcinogenesis.

    Science.gov (United States)

    Lim, Chul-Hong; Lim, Whasun; Jeong, Wooyoung; Lee, Jin-Young; Bae, Seung-Min; Kim, Jinyoung; Han, Jae Yong; Bazer, Fuller W; Song, Gwonhwa

    2013-01-01

    The wingless-type MMTV integration site family of proteins (WNTs) is highly conserved secreted lipid-modified signaling molecules that play a variety of pivotal roles in developmental events such as embryogenesis, tissue homeostasis and cell polarity. Although, of these proteins, WNT4 is known to be involved in genital development in fetuses of mammalian species, its role is unknown in avian species. Therefore, in this study, we investigated expression profiles, as well as hormonal and post-transcriptional regulation of WNT4 expression in the reproductive tract of female chickens. Results of this study demonstrated that WNT4 is most abundant in the stromal and luminal epithelial cells of the isthmus and shell gland of the oviduct, respectively. WNT4 is also most abundant in the glandular epithelium of the shell gland of the oviduct of laying hens at 3 h post-ovulation during the laying cycle. In addition, treatment of young chicks with diethylstilbestrol (DES, a synthetic estrogen agonist) stimulated WNT4 only in the glandular epithelial cells of the isthmus and shell gland of the oviduct. Moreover, results of our study demonstrated that miR-1786 influences WNT4 expression via specific binding sites in its 3'-UTR. On the other hand, our results also indicate that WNT4 is expressed predominantly in the glandular epithelium of cancerous ovaries, but not in normal ovaries of hens. Collectively, these results indicate cell-specific expression of WNT4 in the reproductive tract of chickens and that it likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens.

  13. Integral or integrated marketing

    Directory of Open Access Journals (Sweden)

    Davčik Nebojša

    2006-01-01

    Full Text Available Marketing theorists and experts try to develop business efficient organization and to get marketing performance at higher, business integrated level since its earliest beginnings. The core issue in this paperwork is the dialectic and practical approach dilemma should we develop integrated or integral marketing approach in the organization. The presented company cases as well as dialectic and functional explanations of this dilemma clearly shows that integrated marketing is narrower approach than integral marketing if we take as focal point new, unique and completed entity. In the integration the essence is in getting different parts together, which do not have to make necessary the new entity. The key elements in the definition of the integral marketing are necessity and holistic, e.g. necessity to develop new, holistic entity.

  14. Cavalieri integration

    CSIR Research Space (South Africa)

    Ackermann, ER

    2012-09-01

    Full Text Available We use Cavalieri’s principle to develop a novel integration technique which we call Cavalieri integration. Cavalieri integrals differ from Riemann integrals in that non-rectangular integration strips are used. In this way we can use single Cavalieri...

  15. Integral trees and integral graphs

    NARCIS (Netherlands)

    Wang, Ligong

    2005-01-01

    This monograph deals with integral graphs, Laplacian integral regular graphs, cospectral graphs and cospectral integral graphs. The organization of this work, which consists of eight chapters, is as follows.

  16. Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL® platform

    Directory of Open Access Journals (Sweden)

    Cunningham Julie M

    2010-12-01

    Full Text Available Abstract Background The cDNA-mediated Annealing, extension, Selection and Ligation (DASL assay has become a suitable gene expression profiling system for degraded RNA from paraffin-embedded tissue. We examined assay characteristics and the performance of the DASL 502-gene Cancer Panelv1 (1.5K and 24,526-gene panel (24K platforms at differentiating nine human epidermal growth factor receptor 2- positive (HER2+ and 11 HER2-negative (HER2- paraffin-embedded breast tumors. Methods Bland-Altman plots and Spearman correlations evaluated intra/inter-panel agreement of normalized expression values. Unequal-variance t-statistics tested for differences in expression levels between HER2 + and HER2 - tumors. Regulatory network analysis was performed using Metacore (GeneGo Inc., St. Joseph, MI. Results Technical replicate correlations ranged between 0.815-0.956 and 0.986-0.997 for the 1.5K and 24K panels, respectively. Inter-panel correlations of expression values for the common 498 genes across the two panels ranged between 0.485-0.573. Inter-panel correlations of expression values of 17 probes with base-pair sequence matches between the 1.5K and 24K panels ranged between 0.652-0.899. In both panels, erythroblastic leukemia viral oncogene homolog 2 (ERBB2 was the most differentially expressed gene between the HER2 + and HER2 - tumors and seven additional genes had p-values |0.5| in expression between HER2 + and HER2 - tumors: topoisomerase II alpha (TOP2A, cyclin a2 (CCNA2, v-fos fbj murine osteosarcoma viral oncogene homolog (FOS, wingless-type mmtv integration site family, member 5a (WNT5A, growth factor receptor-bound protein 7 (GRB7, cell division cycle 2 (CDC2, and baculoviral iap repeat-containing protein 5 (BIRC5. The top 52 discriminating probes from the 24K panel are enriched with genes belonging to the regulatory networks centered around v-myc avian myelocytomatosis viral oncogene homolog (MYC, tumor protein p53 (TP53, and estrogen receptor

  17. A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

    Directory of Open Access Journals (Sweden)

    Pluchino Stefano

    2011-07-01

    Full Text Available Abstract Background Dopamine-synthesizing (dopaminergic, DA neurons in the ventral midbrain (VM constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation critically relies on the activation of Wingless-type MMTV integration site (Wnt/β-catenin pathway in their progenitors. In Parkinson's disease, DA cell bodies within the substantia nigra pars compacta (SNpc progressively degenerate, with causes and mechanisms poorly understood. Emerging evidence suggests that Wnt signaling via Frizzled (Fzd receptors may play a role in different degenerative states, but little is known about Wnt signaling in the adult midbrain. Using in vitro and in vivo model systems of DA degeneration, along with functional studies in both intact and SN lesioned mice, we herein highlight an intrinsic Wnt1/Fzd-1/β-catenin tone critically contributing to the survival and protection of adult midbrain DA neurons. Results In vitro experiments identifie Fzd-1 receptor expression at a mRNA and protein levels in dopamine transporter (DAT expressing neurons, and demonstrate the ability of exogenous Wnt1 to exert robust neuroprotective effects against Caspase-3 activation, the loss of tyrosine hydroxylase-positive (TH+ neurons and [3H] dopamine uptake induced by different DA-specific insults, including serum and growth factor deprivation, 6-hydroxydopamine and MPTP/MPP+. Co-culture of DA neurons with midbrain astrocytes phenocopies Wnt1 neuroprotective effects, whereas RNA interference-mediated knockdown of Wnt1 in midbrain astrocytes markedly reduces astrocyte-induced TH+ neuroprotection. Likewise, silencing β-catenin mRNA or knocking down Fzd-1 receptor expression in mesencephalic neurons counteract astrocyte-induced TH+ neuroprotection. In vivo experiments document Fzd-1 co-localization with TH+ neurons within the intact SNpc and blockade of Fzd/β-catenin signaling by unilateral infusion of a Fzd

  18. Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors

    Science.gov (United States)

    Charoenpanich, Adisri; Wall, Michelle E.; Tucker, Charles J.; Andrews, Danica M.K.; Lalush, David S.; Dirschl, Douglas R.

    2014-01-01

    We have shown that the uniaxial cyclic tensile strain of magnitude 10% promotes and enhances osteogenesis of human mesenchymal stem cells (hMSC) and human adipose-derived stem cells (hASC) from normal, nonosteoporotic donors. In the present study, MSC from osteoporotic donors were analyzed for changes in mRNA expression in response to 10% uniaxial tensile strain to identify potential mechanisms underlying the use of this mechanical loading paradigm for prevention and treatment of osteoporosis. Human MSC isolated from three female, postmenopausal osteoporotic donors were analyzed for their responses to mechanical loading using microarray analysis of over 47,000 gene probes. Human MSC were seeded in three-dimensional collagen type I constructs to mimic the organic extracellular matrix of bone and 10% uniaxial cyclic tensile strain was applied to promote osteogenesis. Seventy-nine genes were shown to be regulated within hMSC from osteoporotic donors in response to 10% cyclic tensile strain. Upregulation of six genes were further confirmed with real-time RT-PCR: jun D proto-oncogene (JUND) and plasminogen activator, urokinase receptor (PLAUR), two genes identified as potential key molecules from network analysis; phosphoinositide-3-kinase, catalytic, delta polypeptide (PIK3CD) and wingless-type MMTV integration site family, member 5B (WNT5B), two genes with known importance in bone biology; and, PDZ and LIM domain 4 (PDLIM4) and vascular endothelial growth factor A (VEGFA), two genes that we have previously shown are significantly regulated in hASC in response to this mechanical stimulus. Function analysis indicated that 10% cyclic tensile strain induced expression of genes associated with cell movement, cell proliferation, and tissue development, including development in musculoskeletal and cardiovascular systems. Our results demonstrate that hMSC from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain

  19. Melatonin improves experimental colitis with sleep deprivation.

    Science.gov (United States)

    Park, Young-Sook; Chung, Sook-Hee; Lee, Seong-Kyu; Kim, Ja-Hyun; Kim, Jun-Bong; Kim, Tae-Kyun; Kim, Dong-Shin; Baik, Haing-Woon

    2015-04-01

    Sleep deprivation (SD) is an epidemic phenomenon in modern countries, and its harmful effects are well known. SD acts as an aggravating factor in inflammatory bowel disease. Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized. Thus, in this study, we assessed the measurable effects of SD on experimental colitis and the protective effects of melatonin. For this purpose, male imprinting control region (ICR) mice (n = 24) were used; the mice were divided into 4 experimental groups as follows: the control, colitis, colitis with SD and colitis with SD and melatonin groups. Colitis was induced by the administration of 5% dextran sulfate sodium (DSS) in the drinking water for 6 days. The mice were sleep-deprived for 3 days. Changes in body weight, histological analyses of colon tissues and the expression levels of pro-inflammatory cytokines and genes were evaluated. SD aggravated inflammation and these effects were reversed by melatonin in the mice with colitis. In addition, weight loss in the mice with colitis with SD was significantly reduced by the injection of melatonin. Treatment with melatonin led to high survival rates in the mice, in spite of colitis with SD. The levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-17, interferon-γ and tumor necrosis factor-α, in the serum of mice were significantly increased by SD and reduced by melatonin treatment. The melatonin-treated group showed a histological improvement of inflammation. Upon gene analysis, the expression of the inflammatory genes, protein kinase Cζ (PKCζ) and calmodulin 3 (CALM3), was increased by SD, and the levels decreased following treatment with melatonin. The expression levels of the apoptosis-related inducible nitric oxide synthase (iNOS) and wingless-type MMTV integration site family, member 5A (Wnt5a) genes was

  20. Superdecomposition integrals

    Czech Academy of Sciences Publication Activity Database

    Mesiar, Radko; Li, J.; Pap, E.

    2015-01-01

    Roč. 259, č. 1 (2015), s. 3-11 ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : Choquet integral * Decomposition integral * Superdecomposition integral * Convex integral Subject RIV: BA - General Mathematics Impact factor: 2.098, year: 2015 http://library.utia.cas.cz/separaty/2015/E/mesiar-0442006.pdf

  1. Riemann Integration

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 11. Riemann Integration. Dilip P Patil. General Article Volume 11 Issue 11 November 2006 pp 61-80 ... Keywords. Area; lower and upper sums; Riemann sums; integrable functions; definite integral; derivative; primitive; anti-derivative.

  2. VECTOR INTEGRATION

    NARCIS (Netherlands)

    Thomas, E. G. F.

    2012-01-01

    This paper deals with the theory of integration of scalar functions with respect to a measure with values in a, not necessarily locally convex, topological vector space. It focuses on the extension of such integrals from bounded measurable functions to the class of integrable functions, proving

  3. Interorganisational Integration

    DEFF Research Database (Denmark)

    Lyngsø, Anne Marie; Godtfredsen, Nina Skavlan; Frølich, Anne

    2016-01-01

    INTRODUCTION: Despite many initiatives to improve coordination of patient pathways and intersectoral cooperation, Danish health care is still fragmented, lacking intra- and interorganisational integration. This study explores barriers to and facilitators of interorganisational integration...... at a university hospital in the Capital Region of Denmark. RESULTS AND DISCUSSION: Our results can be grouped into five influencing areas for interorganisational integration: communication/information transfer, committed leadership, patient engagement, the role and competencies of the general practitioner...... and organisational culture. Proposed solutions to barriers in each area hold the potential to improve care integration as experienced by individuals responsible for supporting and facilitating it. Barriers and facilitators to integrating care relate to clinical, professional, functional and normative integration...

  4. Integrated Science.

    Science.gov (United States)

    Rainey, Larry; Miller, Roxanne Greitz

    1997-01-01

    Describes the Integrated Science program that integrates biology, earth/space science, chemistry, and physics over a three-year, spiraling sequence arranged around broad themes such as cycles, changes, patterns, and waves. Includes weekly telecasts via public television and satellite, teacher manuals, student handbooks, e-mail connections, staff…

  5. Integrated Design

    DEFF Research Database (Denmark)

    Lenau, Torben Anker

    1999-01-01

    A homepage on the internet with course material, lecture plan, student exercises, etc. Continuesly updated during the course Integrated Design (80402, 80403)......A homepage on the internet with course material, lecture plan, student exercises, etc. Continuesly updated during the course Integrated Design (80402, 80403)...

  6. The integration of immigrants

    OpenAIRE

    Bauböck, Rainer

    1995-01-01

    from the Table of Contents: Migration and integration - Basic concepts and definitions; Immigration and Integration policies; The legal framework for integration; Dimension of social integration; Cultural integration; Conclusions;

  7. Integration of Chandrasekhar's integral equation

    International Nuclear Information System (INIS)

    Tanaka, Tasuku

    2003-01-01

    We solve Chandrasekhar's integration equation for radiative transfer in the plane-parallel atmosphere by iterative integration. The primary thrust in radiative transfer has been to solve the forward problem, i.e., to evaluate the radiance, given the optical thickness and the scattering phase function. In the area of satellite remote sensing, our problem is the inverse problem: to retrieve the surface reflectance and the optical thickness of the atmosphere from the radiance measured by satellites. In order to retrieve the optical thickness and the surface reflectance from the radiance at the top-of-the atmosphere (TOA), we should express the radiance at TOA 'explicitly' in the optical thickness and the surface reflectance. Chandrasekhar formalized radiative transfer in the plane-parallel atmosphere in a simultaneous integral equation, and he obtained the second approximation. Since then no higher approximation has been reported. In this paper, we obtain the third approximation of the scattering function. We integrate functions derived from the second approximation in the integral interval from 1 to ∞ of the inverse of the cos of zenith angles. We can obtain the indefinite integral rather easily in the form of a series expansion. However, the integrals at the upper limit, ∞, are not yet known to us. We can assess the converged values of those series expansions at ∞ through calculus. For integration, we choose coupling pairs to avoid unnecessary terms in the outcome of integral and discover that the simultaneous integral equation can be deduced to the mere integral equation. Through algebraic calculation, we obtain the third approximation as a polynomial of the third degree in the atmospheric optical thickness

  8. Strobed integrator

    International Nuclear Information System (INIS)

    Krasnokutskij, R.N.; Kurchaninov, L.L.; Fedyakin, N.N.; Shuvalov, R.S.

    1989-01-01

    Two measuring techniques for signal amplitude of particle detector without the in-side amplification: with peak detector and with strobed integrator are compared. Simple formulae to calculate noise value at the output of strobed integrator are derived. Usage of strobed integrator is shown to enable to increase essentially counting rate as compared to peak detector at the same noise level. Optimal positioning strobe-pulse with regard to the input signal is determined. Equivalent noise charge ar signal shaping sifferent schemes is calculated

  9. Stochastic integrals

    CERN Document Server

    McKean, Henry P

    2005-01-01

    This little book is a brilliant introduction to an important boundary field between the theory of probability and differential equations. -E. B. Dynkin, Mathematical Reviews This well-written book has been used for many years to learn about stochastic integrals. The book starts with the presentation of Brownian motion, then deals with stochastic integrals and differentials, including the famous Itô lemma. The rest of the book is devoted to various topics of stochastic integral equations, including those on smooth manifolds. Originally published in 1969, this classic book is ideal for supplemen

  10. Integrated optics

    International Nuclear Information System (INIS)

    Jekowski, J.; Aeby, I.

    1979-01-01

    The purpose of the R and D effort is to establish a baseline technology in integrated optic techniques within the EMG. Significant investment presently being made by industry in this area indicates that this technology may offer an alternative solution for high speed digital data acquisition and transmission. The objectives of this year's integrated optics program were three-fold: (1) to establish a literature search and maintain industry contacts in an attempt to make the needs of the Weapons Test Program known; (2) to assist the Las Vegas Hybrid facility in establising integrated optic fabrication techniques for their new Thin Film Laboratory; and (3) to conduct basic experiments at Los Alamos in the construction of photolithograhicaly etched plastic film devices. The report describes the successful completion of preliminary investigations into photolithographic techniques and continuing investigations into newly announced integrated optic techniques and devices that would be applicable to the weapons test program

  11. Integral cryptanalysis

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Wagner, David

    2002-01-01

    This paper considers a cryptanalytic approach called integral cryptanalysis. It can be seen as a dual to differential cryptanalysis and applies to ciphers not vulnerable to differential attacks. The method is particularly applicable to block ciphers which use bijective components only.......This paper considers a cryptanalytic approach called integral cryptanalysis. It can be seen as a dual to differential cryptanalysis and applies to ciphers not vulnerable to differential attacks. The method is particularly applicable to block ciphers which use bijective components only....

  12. Organising integration

    DEFF Research Database (Denmark)

    Axelsson, Runo

    2013-01-01

    to large-scale bureaucratic structures of centralised control. In the 1980’s there was a period of decentralisation to smaller organisational units, which was followed in the 1990’s by an introduction of market mechanisms in accordance with the New Public Management. During this period, there has been......Background: In Sweden, as in many other countries, there has been a succession of trends in the organisation of health care and other welfare services. These trends have had different implications for the integration of services in the health and welfare system. Aims: One aim is to discuss...... the implications of different organisational trends for the integration of health and welfare services. Another aim is to introduce a Swedish model of financial coordination as a flexible way to organise integration. Organisational trends: In the 1960’s there was an expansion of health and welfare services leading...

  13. Lebesgue integration

    CERN Document Server

    Williamson, JH

    2014-01-01

    This concise introduction to Lebesgue integration is geared toward advanced undergraduate math majors and may be read by any student possessing some familiarity with real variable theory and elementary calculus. The self-contained treatment features exercises at the end of each chapter that range from simple to difficult. The approach begins with sets and functions and advances to Lebesgue measure, including considerations of measurable sets, sets of measure zero, and Borel sets and nonmeasurable sets. A two-part exploration of the integral covers measurable functions, convergence theorems, co

  14. Integrated Design

    DEFF Research Database (Denmark)

    Jørgensen, Michael; Nielsen, M. W.; Strømann-Andersen, Jakob Bjørn

    2011-01-01

    This paper presents a case study of the implementation of integrated design in an actual architectural competition. The design process was carried out at a highly esteemed architectural office and attended by both engineers and architects working towards mutual goals of architectural excellence......, low-energy consumption, and high-quality indoor environment. We use this case study to investigate how technical knowledge about building performance can be integrated into the conceptual design stage. We have selected certain points during the design process that represented design challenges......'s performance. This article illustrates how a continuous implementation of technical knowledge early in the design process for an actual architectural competition resulted in a building design with an energy demand approximately 30% lower than Danish building regulations, yet which still maintains a high...

  15. Integrated Toys

    DEFF Research Database (Denmark)

    Petersson, Eva

    2005-01-01

    Toys play a crucial role in supporting children’s learning and creation of meaning in their everyday life. Children also play with toys out of an interest to interact with others e.g. peers and adults. Tendencies of digital technology in toys have led to greater opportunities for manipulation...... changed our everyday lives. However, its contribution in development of new suitable material for play and learning has not been appropriate. We argue that play is a fruitful base for learning and training and that the design of physical and virtual artifacts advantageously should rest upon...... and interaction with the integrated toy as a virtual experience without attachment or wearable on the body, which in context would not be appropriate. In the field of rehabilitation integrated toys are still at an embryonic stage and as such an under used resource for rehabilitation. Qualitative method...

  16. Scientific integrity

    DEFF Research Database (Denmark)

    Merlo, Domenico Franco; Vahakangas, Kirsi; Knudsen, Lisbeth E.

    2008-01-01

    Environmental health research is a relatively new scientific area with much interdisciplinary collaboration. Regardless of which human population is included in field studies (e.g., general population, working population, children, elderly, vulnerable sub-groups, etc.) their conduct must guarantee...... consent was obtained.Integrity is central to environmental health research searching for causal relations. It requires open communication and trust and any violation (i.e., research misconduct, including fabrication or falsification of data, plagiarism, conflicting interests, etc.) may endanger...

  17. Homeland Integration

    Directory of Open Access Journals (Sweden)

    Bin Ai

    2017-03-01

    Full Text Available In this study, the first author narrates his experiences of the challenges of integration into several Chinese universities as a PhD graduate after returning from Australia. His patterns of communication and psychological changes are examined in terms of identity construction and transformation. His insider position as a Chinese native and academic returnee enables him to see the realities of practice in average Chinese universities at close range, yet with the altered vision gained from his overseas experience. This study highlights the challenges for academic returnees in Chinese higher education institutions and may also have resonances for academic returnees in other countries. Wider questions about the assessment of English research writing and the attitudes to academic returnees in Chinese universities are raised, contributing to debate over the future development of Chinese higher education institutions in a globalizing world.

  18. Numerical Contour Integration for Loop Integrals

    OpenAIRE

    Kurihara, Y.; Kaneko, T.

    2005-01-01

    A fully numerical method to calculate loop integrals, a numerical contour-integration method, is proposed. Loop integrals can be interpreted as a contour integral in a complex plane for an integrand with multi-poles in the plane. Stable and efficient numerical integrations an along appropriate contour can be performed for tensor integrals as well as for scalar ones appearing in loop calculations of the standard model. Examples of 3- and 4-point diagrams in 1-loop integrals and 2- and 3-point ...

  19. Definite Integrals using Orthogonality and Integral Transforms

    Directory of Open Access Journals (Sweden)

    Howard S. Cohl

    2012-10-01

    Full Text Available We obtain definite integrals for products of associated Legendre functions with Bessel functions, associated Legendre functions, and Chebyshev polynomials of the first kind using orthogonality and integral transforms.

  20. Sesquilinear uniform vector integral

    Indian Academy of Sciences (India)

    absolute integral which generalizes the Lebesgue integral and is more easy to manipulate. We speak so far about scalar integrals (scalar functions integrated with respect to positive measures-speaking approximately). The idea of integrating vector functions with respect to scalar measures came naturally on the scene of ...

  1. Determine Arbitrary Feynman Integrals by Vacuum Integrals

    OpenAIRE

    Liu, Xiao; Ma, Yan-Qing

    2018-01-01

    By introducing an auxiliary parameter, we find a series representation for Feynman integral, which is defined as analytical continuation of a calculable series. To obtain the series representation, one only needs to deal with some much simpler vacuum integrals. The series representation therefore translates the problem of computing Feynman integrals to the problem of performing analytical continuations. As a Feynman integral is fully determined by its series representation, its reduction rela...

  2. Wealth Through Integration: Regional Integration and Poverty ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Wealth Through Integration: Regional Integration and Poverty-Reduction Strategies in West Africa. Book cover Wealth Through Integration. Directeur(s) : Elias T. Ayuk and Samuel T. Kaboré. Maison(s) d'édition : Springer, IDRC. 27 février 2013. ISBN : 9781461444145. 297 pages. e-ISBN : 9781552505441. Téléchargez le ...

  3. Simplification of integrity constraints for data integration

    DEFF Research Database (Denmark)

    Christiansen, Henning; Martinenghi, Davide

    2004-01-01

    When two or more databases are combined into a global one, integrity may be violated even when each database is consistent with its own local integrity constraints. Efficient methods for checking global integrity in data integration systems are called for: answers to queries can then be trusted......, because either the global database is known to be consistent or suitable actions have been taken to provide consistent views. The present work generalizes simplification techniques for integrity checking in traditional databases to the combined case. Knowledge of local consistency is employed, perhaps...... together with given a priori constraints on the combination, so that only a minimal number of tuples needs to be considered. Combination from scratch, integration of a new source, and absorption of local updates are dealt with for both the local-as-view and global-as-view approaches to data integration....

  4. Tactical Systems Integration Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Tactical Systems Integration Laboratory is used to design and integrate computer hardware and software and related electronic subsystems for tactical vehicles....

  5. Pro Spring Integration

    CERN Document Server

    Lui, M; Chan, Andy; Long, Josh

    2011-01-01

    Pro Spring Integration is an authoritative book from the experts that guides you through the vast world of enterprise application integration (EAI) and application of the Spring Integration framework towards solving integration problems. The book is:. * An introduction to the concepts of enterprise application integration * A reference on building event-driven applications using Spring Integration * A guide to solving common integration problems using Spring Integration What makes this book unique is its coverage of contemporary technologies and real-world information, with a focus on common p

  6. The mature reverse transcriptase molecules in virions of mouse mammary tumor virus possess protease-derived sequences

    International Nuclear Information System (INIS)

    Entin-Meer, Michal; Avidan, Orna; Hizi, Amnon

    2003-01-01

    Our efforts to express in bacteria the enzymatically active reverse transcriptase (RT) of mouse mammary tumor virus (MMTV) have shown that the RT is active only after adding 27 amino acid residues, which are derived from the end of the pro gene, to the amino-terminus of the RT (Biochem, J. (1998) 329, 579-587). In the present study we have tested whether the mature RT found in virions is also fused to protease-derived sequences. To this end, we have analyzed the RT molecules in virions of MMTV by using two antisera directed against peptides, derived from either the carboxyl-terminus of MMTV protease or the middle of MMTV RT. The data suggest that the mature RT, located in virions, contains at its amino-terminus sequences from the carboxyl-terminus of the protease protein. This finding supports previous suggestions that MMTV RT is a transframe protein (derived from both pro and pol reading frames of MMTV) and that amino acid residues located at the carboxyl-terminus of the protease have a dual usage as integral parts of both the protease and the RT enzymes

  7. SAP crm integration testing

    OpenAIRE

    Černiavskaitė, Marija

    2017-01-01

    This Bachelor's thesis presents SAP CRM and integration systems testing analysis: investigation in SAP CRM and SAP PO systems, presentation of relationship between systems, introduction to third-party system (non-SAP) – Network Informational System (NIS) which has integration with SAP, presentation of best CRM testing practises, analysis and recommendation of integration testing. Practical integration testing is done in accordance to recommendations.

  8. Probabilistic Data Integration

    NARCIS (Netherlands)

    van Keulen, Maurice

    2017-01-01

    Probabilistic data integration is a specific kind of data integration where integration problems such as inconsistency and uncertainty are handled by means of a probabilistic data representation. The approach is based on the view that data quality problems (as they occur in an integration process)

  9. How integrated are immigrants?

    Directory of Open Access Journals (Sweden)

    Rickard Sandell

    2015-12-01

    Full Text Available Background: The successful integration of immigrants is seen as a principal means to secure economic growth and welfare in many countries. Success in this task depends on the capacity to formulate effective integration policies, which in turn is based on research capable of describing and explaining the integration process properly. Objective: Our objective is to define a conceptual and quantifiable measure of full immigrant integration.This enables a quantitative evaluation of how integrated immigrants are in a specific context in an immigrant - native system - a question poorly addressed by past research. Methods: Our approach consists of looking at the functional dependency of different integrationquantifiers on immigrant density. The empirical analysis uses register data from Spain. We focus on social integration and labour market integration in formal employment. Results: In our empirical analysis we find dramatic differences in immigrant integration levels across integration contexts. While labour market integration approaches the level of full integration, social integration quickly declines as immigration levels surge. It is shown that these differences are primarily due to the presence of social network effects in the social integration process, absent in the labour market integration process. Conclusions: Proper identification of integration deficits and its causes is likely to improve the efficiency of integration policy making, and the capacity to reach integration targets. Our framework has this quality. The research presented here shows that full labour market integration of immigrants is a realistic target. However, it also shows that, if left unattended, the segregation forces contained in social networks, quite dramatically obstruct the social integration process. Lack of social integration undermines the strategy of reliance on increasing immigration to secure future economic well-being that many governments andinternational

  10. Buried waste integrated demonstration technology integration process

    International Nuclear Information System (INIS)

    Ferguson, J.S.; Ferguson, J.E.

    1992-04-01

    A Technology integration Process was developed for the Idaho National Energy Laboratories (INEL) Buried Waste Integrated Demonstration (BWID) Program to facilitate the transfer of technology and knowledge from industry, universities, and other Federal agencies into the BWID; to successfully transfer demonstrated technology and knowledge from the BWID to industry, universities, and other Federal agencies; and to share demonstrated technologies and knowledge between Integrated Demonstrations and other Department of Energy (DOE) spread throughout the DOE Complex. This document also details specific methods and tools for integrating and transferring technologies into or out of the BWID program. The document provides background on the BWID program and technology development needs, demonstrates the direction of technology transfer, illustrates current processes for this transfer, and lists points of contact for prospective participants in the BWID technology transfer efforts. The Technology Integration Process was prepared to ensure compliance with the requirements of DOE's Office of Technology Development (OTD)

  11. Cavalieri Integration - CSIR Technical report

    CSIR Research Space (South Africa)

    Grobler, TL

    2011-10-01

    Full Text Available The authors use Cavalieri's principle to develop a novel integration technique which they call Cavalieri integration. Cavalieri integrals differ from Riemann integrals in that non-rectangular integration strips are used. In this way they can use...

  12. Communicating European Integration – Information vs. Integration?

    Directory of Open Access Journals (Sweden)

    Alexander Reinfeldt

    2014-02-01

    Full Text Available This article deals with the apparent contradiction between elite-driven supranational European integration and public information efforts by supranational political actors from the early 1950s. Supranational European integration relied on rational governance by independent experts which provoked a structural democratic deficit. Until the early 1970s public participation had never been the main preoccupation of supranational political actors who instead considered the ‘permissive consensus’ to be a precondition for progress towards further European integration. And yet, from the very beginning European supranational political actors pursued information policies. At first, the article reconsiders the rationale of supranational European integration and outlines the basic features of supranational information policies. Then, the article empirically analyses the purposes that guided supranational political actors like the High Authority of the European Coal and Steel Community (ECSC and the Commissions of the European Economic Community (EEC and the European Atomic Community (EURATOM in pursuing information policies at all by discussing two significant examples: the EC information efforts directed at young audiences and the participation of the EC in fairs and exhibitions. It is argued that information policies were only in part pursued to communicate European integration to the public or to influence public opinion on European integration issues. In fact, the main intention and impact of supranational information efforts was to foster transnational European integration and co-operation, for example between member state governments and administrations, non-governmental actors or associations.

  13. MicroRNA-24 Attenuates Neointimal Hyperplasia in the Diabetic Rat Carotid Artery Injury Model by Inhibiting Wnt4 Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Jian Yang

    2016-05-01

    Full Text Available The long-term stimulation of hyperglycemia greatly increases the incidence of vascular restenosis (RS after angioplasty. Neointimal hyperplasia after vascular injury is the pathological cause of RS, but its mechanism has not been elucidated. MicroRNA-24 (miR-24 has low expression in the injured carotid arteries of diabetic rats. However, the role of miR-24 in the vascular system is unknown. In this study, we explore whether over-expression of miR-24 could attenuate neointimal formation in streptozotocin (STZ-induced diabetic rats. Adenovirus (Ad-miR-24-GFP was used to deliver the miR-24 gene to injured carotid arteries in diabetic rats. The level of neointimal hyperplasia was examined by hematoxylin-eosin (HE staining. Vascular smooth muscle cell (VSMC proliferation in the neointima was evaluated by immunostaining for proliferating cell nuclear antigen (PCNA. The mRNA levels of miR-24, PCNA, wingless-type MMTV integration site family member 4 (Wnt4, disheveled-1 (Dvl-1, β-catenin and cell cycle-associated molecules (Cyclin D1, p21 were determined by Quantitative Real-Time PCR (qRT-PCR. PCNA, Wnt4, Dvl-1, β-catenin, Cyclin D1 and p21 protein levels were measured by Western blotting analysis. STZ administration decreased plasma insulin and increased fasting blood glucose in Sprague-Dawley (SD rats. The expression of miR-24 was decreased in the carotid artery after a balloon injury in diabetic rats, and adenoviral transfection (Ad-miR-24-GFP increased the expression of miR-24. Over-expression of miR-24 suppressed VSMC proliferation and neointimal hyperplasia in diabetic rats at 14 days. Furthermore, compared with Sham group, the mRNA and protein levels of PCNA, Wnt4, Dvl-1, β-catenin, and Cyclin D1 were strikingly up-regulated in the carotid arteries of diabetic rats after a balloon injury. Interestingly, up-regulation of miR-24 significantly reduced the mRNA and protein levels of these above molecules. In contrast, the change trend in p21 m

  14. Change in subcutaneous adipose tissue metabolism and gene network expression during the transition period in dairy cows, including differences due to sire genetic merit.

    Science.gov (United States)

    Khan, M J; Hosseini, A; Burrell, S; Rocco, S M; McNamara, J P; Loor, J J

    2013-04-01

    Adipose metabolism is an essential contributor to the efficiency of milk production, and metabolism is controlled by several mechanisms, including gene expression of critical proteins; therefore, the objective of this study was to determine how lactational state and the genetic merit of dairy cattle affects adipose tissue (AT) metabolism and mRNA expression of genes known to control metabolism. Animals of high (HGM) and low genetic merit (LGM) were fed to requirements, and weekly dry matter intake, milk production, blood glucose, and nonesterified fatty acids were measured. Subcutaneous AT biopsies were collected at -21, 7, 28 and 56 d in milk (DIM). The mRNA expression of genes coding for lipogenic enzymes [phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1), fatty acid synthase (FASN), diacylglycerol O-acyltransferase 2 (DGAT2), and stearoyl-coenzyme A desaturase (SCD)], transcription regulators [peroxisome proliferator-activated receptor γ (PPARG), thyroid hormone responsive (THRSP), wingless-type MMTV integration site family, member 10B (WNT10B), sterol regulatory element binding transcription factor 1 (SREBF1), and adiponectin (ADIPOQ)], lipolytic enzymes [hormone-sensitive lipase (LIPE), patatin-like phospholipase domain containing 2 (PNPLA2), monoglyceride lipase (MGLL), adrenoceptor β-2 (ADRB2), adipose differentiation-related protein (ADFP), and α-β-hydrolase domain containing 5 (ABHD5)], and genes controlling the sensing of intracellular energy [phosphodiesterase 3A (PDE3A); PDE3B; protein kinase, AMP-activated, α-1 catalytic subunit (PRKAA1); PRKAA2; and growth hormone receptor (GHR)] was measured. Dry matter intake, blood glucose, and nonesterified fatty acid concentrations did not differ between genetic merit groups. Milk production was greater for HGM cows from 6 to 8 wk postpartum. As expected, the rates of lipogenesis decreased in early lactation, whereas stimulated lipolysis increased. At 7 DIM, lipogenesis in HGM cows increased as a function

  15. One loop integrals reduction

    International Nuclear Information System (INIS)

    Sun Yi; Chang Haoran

    2012-01-01

    By further examining the symmetry of external momenta and masses in Feynman integrals, we fulfilled the method proposed by Battistel and Dallabona, and showed that recursion relations in this method can be applied to simplify Feynman integrals directly. (authors)

  16. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    The Integrated Renovation Process (IRP) is a user customized methodology based on judiciously selected constructivist and interactive multi-criteria decision making methods (Galiotto, Heiselberg, & Knudstrup, 2014 (expected)). When applied for home renovation, the Integrated Renovation Process...

  17. Semantic Integration Technonolgies Survey

    OpenAIRE

    Kalfoglou, Yannis; Hu, Bo; Reynolds, Dave; Shadbolt, Nigel

    2005-01-01

    The \\underline{University of Southampton} and \\underline{Hewlett Packard Laboratories at Bristol} are collaborating in a joint project, CROSI, to investigate semantic integration. \\textbf{CROSI}, which stands for Capturing, Representing, and Operationalising Semantic Integration, aims to advance the state-of-the-art for semantic integration technologies. Semantic integration has become a much debated topic in today's research agenda, especially with the advent of the Semantic Web. Its roots, ...

  18. Integrated optics technology study

    Science.gov (United States)

    Chen, B.

    1982-01-01

    The materials and processes available for the fabrication of single mode integrated electrooptical components are described. Issues included in the study are: (1) host material and orientation, (2) waveguide formation, (3) optical loss mechanisms, (4) wavelength selection, (5) polarization effects and control, (6) laser to integrated optics coupling,(7) fiber optic waveguides to integrated optics coupling, (8) souces, (9) detectors. The best materials, technology and processes for fabrication of integrated optical components for communications and fiber gyro applications are recommended.

  19. Integrated vs. Federated Search

    DEFF Research Database (Denmark)

    Løvschall, Kasper

    2009-01-01

    Oplæg om forskelle og ligheder mellem integrated og federated search i bibliotekskontekst. Holdt ved temadag om "Integrated Search - samsøgning i alle kilder" på Danmarks Biblioteksskole den 22. januar 2009.......Oplæg om forskelle og ligheder mellem integrated og federated search i bibliotekskontekst. Holdt ved temadag om "Integrated Search - samsøgning i alle kilder" på Danmarks Biblioteksskole den 22. januar 2009....

  20. Boolean integral calculus

    Science.gov (United States)

    Tucker, Jerry H.; Tapia, Moiez A.; Bennett, A. Wayne

    1988-01-01

    The concept of Boolean integration is developed, and different Boolean integral operators are introduced. Given the changes in a desired function in terms of the changes in its arguments, the ways of 'integrating' (i.e. realizing) such a function, if it exists, are presented. The necessary and sufficient conditions for integrating, in different senses, the expression specifying the changes are obtained. Boolean calculus has applications in the design of logic circuits and in fault analysis.

  1. Integration phenomena Paralympic cyclists

    OpenAIRE

    Diepoldová, Tereza

    2017-01-01

    Title: Integration phenomena Paralympic cyclists. Objectives of work: Try to find integration phenomena in relation to sport training and its impact on selected cyclists with disabilities. Methods: Case report structured interview, data collection method - the method of interrogation. Results: Based on case studies developed a structured interview, we found differences in the integration, which we have divided into phases - before obtaining disability, acclimatization, sports integration. Fur...

  2. Spring integration essentials

    CERN Document Server

    Pandey, Chandan

    2015-01-01

    This book is intended for developers who are either already involved with enterprise integration or planning to venture into the domain. Basic knowledge of Java and Spring is expected. For newer users, this book can be used to understand an integration scenario, what the challenges are, and how Spring Integration can be used to solve it. Prior experience of Spring Integration is not expected as this book will walk you through all the code examples.

  3. Optimizing Computer Technology Integration

    Science.gov (United States)

    Dillon-Marable, Elizabeth; Valentine, Thomas

    2006-01-01

    The purpose of this study was to better understand what optimal computer technology integration looks like in adult basic skills education (ABSE). One question guided the research: How is computer technology integration best conceptualized and measured? The study used the Delphi method to map the construct of computer technology integration and…

  4. Foundations for Psychotherapy Integration

    Directory of Open Access Journals (Sweden)

    António Branco Vasco

    2014-10-01

    Full Text Available The movement for integration in psychotheray is clearly one of the main trends that can be observed in the field. The author stresses three main reasons for this state of affairs and as a way of justifying the importance of integration: historical and psychosocial, empirical and philosophical. A specific way of thinking in integrative terms is also outlined - "paradigmatic complementarity."

  5. Discrete bipolar universal integrals

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    2014-01-01

    Roč. 252, č. 1 (2014), s. 55-65 ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * universal integral * Choquet integral Subject RIV: BA - General Mathematics Impact factor: 1.986, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0432224.pdf

  6. Sledge-Hammer Integration

    Science.gov (United States)

    Ahner, Henry

    2009-01-01

    Integration (here visualized as a pounding process) is mathematically realized by simple transformations, successively smoothing the bounding curve into a straight line and the region-to-be-integrated into an area-equivalent rectangle. The relationship to Riemann sums, and to the trapezoid and midpoint methods of numerical integration, is…

  7. Four integration patterns

    DEFF Research Database (Denmark)

    Bygstad, Bendik; Nielsen, Peter Axel; Munkvold, Bjørn Erik

    2010-01-01

    . Expanding the perspective of traditional project management research, we draw extensively on central insights from IS research. Building on socio-technical IS research and Software Engineering research we suggest four generic patterns of integration: Big Bang, Stakeholder Integration, Technical Integration...

  8. Curriculum Integration: An Overview

    Science.gov (United States)

    Wall, Amanda; Leckie, Alisa

    2017-01-01

    Curriculum integration is a tenet of middle level education. "This We Believe," the position paper of the Association for Middle Level Education, advocates for curriculum that is exploratory, relevant, integrative, and meaningful for young adolescents. Teachers can integrate curriculum across content areas by anchoring units of study in…

  9. Steffensen's integral inequality for conformable fractional integrals

    Directory of Open Access Journals (Sweden)

    Mehmet Zeki Sarikaya

    2017-09-01

    Full Text Available The aim of this paper is to establish some Steffensen’s type inequalities for conformable fractional integral. The results presented here would provide generalizations of those given in earlier works.

  10. Photonic Integrated Circuits

    Science.gov (United States)

    Krainak, Michael; Merritt, Scott

    2016-01-01

    Integrated photonics generally is the integration of multiple lithographically defined photonic and electronic components and devices (e.g. lasers, detectors, waveguides passive structures, modulators, electronic control and optical interconnects) on a single platform with nanometer-scale feature sizes. The development of photonic integrated circuits permits size, weight, power and cost reductions for spacecraft microprocessors, optical communication, processor buses, advanced data processing, and integrated optic science instrument optical systems, subsystems and components. This is particularly critical for small spacecraft platforms. We will give an overview of some NASA applications for integrated photonics.

  11. Integration of generic issues

    International Nuclear Information System (INIS)

    Thatcher, D.

    1989-01-01

    The NRC has recognized the need to integrate generic issues (GIs). The GI process includes a number of phases, all of which should recognize the potential for overlap and conflict among related issues. In addition to the issues themselves, other related NRC and industry programs and activities need to be factored into the GI process. Integration has taken place, or is taking place, for a number of GIs. Each case of integration involves a specific set of circumstances and, as a result, the way in which integration proceeds can vary. This paper discusses the integration of issues in the generic issue process and provides a number of examples

  12. Nature-based integration

    DEFF Research Database (Denmark)

    Pitkänen, Kati; Oratuomi, Joose; Hellgren, Daniela

    Increased attention to, and careful planning of the integration of migrants into Nordic societies is ever more important. Nature based integration is a new solution to respond to this need. This report presents the results of a Nordic survey and workshop and illustrates current practices of nature...... based integration by case study descriptions from Denmark, Sweden Norway and Finland. Across Nordic countries several practical projects and initiatives have been launched to promote the benefits of nature in integration and there is also growing academic interest in the topic. Nordic countries have...... the potential of becoming real forerunners in nature based integration even at the global scale....

  13. Entrepreneurial Integration Skills

    DEFF Research Database (Denmark)

    Bauer, Florian; Schriber, Svante; King, David R.

    2016-01-01

    Acquisition integration is important to realize synergies and to achieve acquisition success. However, there is a lack of clarity on pertinent integration approaches suggesting that integration is more complex and dynamic than traditionally assumed. In this chapter, we shed light on ambiguous cause...... effect relationships by investigating the effect of integration related decisions on intermediate goals. Additionally, we argue that entrepreneurial integration skills, or proactivity under ambiguity, are needed to keep pace with the dynamism inherent in acquisition integration. Based on primary data...... on 116 acquisitions, we find that entrepreneurial integration skills can display both advantages and disadvantages. While it helps to realize expected and serendipitous synergies, it can also trigger employee uncertainty due to decreased transparency. In supplementary analysis, we show measures...

  14. Searching for integrable systems

    International Nuclear Information System (INIS)

    Cary, J.R.

    1984-01-01

    Lack of integrability leads to undesirable consequences in a number of physical systems. The lack of integrability of the magnetic field leads to enhanced particle transport in stellarators and tokamaks with tearing-mode turbulence. Limitations of the luminosity of colliding beams may be due to the onset of stochasticity. Enhanced radial transport in mirror machines caused by the lack of integrability and/or the presence of resonances may be a significant problem in future devices. To improve such systems one needs a systematic method for finding integrable systems. Of course, it is easy to find integrable systems if no restrictions are imposed; textbooks are full of such examples. The problem is to find integrable systems given a set of constraints. An example of this type of problem is that of finding integrable vacuum magnetic fields with rotational transform. The solution to this problem is relevant to the magnetic-confinement program

  15. Immigrant Integration: Acculturation and Social Integration

    Directory of Open Access Journals (Sweden)

    Astrid HAMBERGER

    2009-11-01

    Full Text Available This article tackles the concept of “immigrant integration” as it is analyzed by different authors in the international migration field. In this article, I will use the terms “refugee” and “immigrant” as equivalent to each other due to the interchangeable character of these concepts throughout the integration literature. First, the article brings into discussion the definitional and conceptual battle around the concept of immigrant “integration”, and second, it will describe and analyze cultural and social integration with their presupposing processes.

  16. Integrated management systems

    CERN Document Server

    Bugdol, Marek

    2015-01-01

    Examining the challenges of integrated management, this book explores the importance and potential benefits of using an integrated approach as a cross-functional concept of management. It covers not only standardized management systems (e.g. International Organization for Standardization), but also models of self-assessment, as well as different types of integration. Furthermore, it demonstrates how processes and systems can be integrated, and how management efficiency can be increased. The major part of this book focuses on management concepts which use integration as a key tool of management processes (e.g. the systematic approach, supply chain management, virtual and network organizations, processes management and total quality management). Case studies, illustrations, and tables are also provided to exemplify and illuminate the content, as well as examples of successful and failed integrations. Providing a particularly useful resource to managers and specialists involved in the improvement of organization...

  17. Integration of reusable systems

    CERN Document Server

    Rubin, Stuart

    2014-01-01

    Software reuse and integration has been described as the process of creating software systems from existing software rather than building software systems from scratch. Whereas reuse solely deals with the artifacts creation, integration focuses on how reusable artifacts interact with the already existing parts of the specified transformation. Currently, most reuse research focuses on creating and integrating adaptable components at development or at compile time. However, with the emergence of ubiquitous computing, reuse technologies that can support adaptation and reconfiguration of architectures and components at runtime are in demand. This edited book includes 15 high quality research papers written by experts in information reuse and integration to cover the most recent advances in the field. These papers are extended versions of the best papers which were presented at IEEE International Conference on Information Reuse and Integration and IEEE International Workshop on Formal Methods Integration, which wa...

  18. What constitutes information integrity?

    Directory of Open Access Journals (Sweden)

    S. Flowerday

    2007-12-01

    Full Text Available This research focused on what constitutes information integrity as this is a problem facing companies today. Moreover, information integrity is a pillar of information security and is required in order to have a sound security management programme. However, it is acknowledged that 100% information integrity is not currently achievable due to various limitations and therefore the auditing concept of reasonable assurance is adopted. This is in line with the concept that 100% information security is not achievable and the notion that adequate security is the goal, using appropriate countermeasures. The main contribution of this article is to illustrate the importance of and provide a macro view of what constitutes information integrity. The findings are in harmony with Samuel Johnson's words (1751: 'Integrity without knowledge is weak and useless, and knowledge without integrity is dangerous and dreadful.'

  19. What constitutes information integrity?

    Directory of Open Access Journals (Sweden)

    S. Flowerday

    2008-01-01

    Full Text Available This research focused on what constitutes information integrity as this is a problem facing companies today. Moreover, information integrity is a pillar of information security and is required in order to have a sound security management programme. However, it is acknowledged that 100% information integrity is not currently achievable due to various limitations and therefore the auditing concept of reasonable assurance is adopted. This is in line with the concept that 100% information security is not achievable and the notion that adequate security is the goal, using appropriate countermeasures. The main contribution of this article is to illustrate the importance of and provide a macro view of what constitutes information integrity. The findings are in harmony with Samuel Johnson's words (1751: 'Integrity without knowledge is weak and useless, and knowledge without integrity is dangerous and dreadful.'

  20. Integrated management systems

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg; Remmen, Arne; Mellado, M. Dolores

    2006-01-01

    of integration. The focus of the article is primarily to discuss three ambition levels of integration: from increased compatibility of system elements over coordination of generic processes to an embeddedness of an integrated management system (IMS) in a culture of learning and continuous improvements......Different approaches to integration of management systems (ISO 9001, ISO 14001, OHSAS 18001 and SA 8000) with various levels of ambition have emerged. The tendency of increased compatibility between these standards has paved the road for discussions of, how to understand the different aspects....... At present, national IMS standards are being developed, and the IMS standards in Denmark and Spain are being analysed regarding the ambition level for integration. Should the ISO organisation decide to make a standard for IMS, then it would be necessary to consider the different levels of integration...

  1. Classical Mechanics and Symplectic Integration

    DEFF Research Database (Denmark)

    Nordkvist, Nikolaj; Hjorth, Poul G.

    2005-01-01

    Content: Classical mechanics: Calculus of variations, Lagrange’s equations, Symmetries and Noether’s theorem, Hamilton’s equations, cannonical transformations, integrable systems, pertubation theory. Symplectic integration: Numerical integrators, symplectic integrators, main theorem on symplectic...

  2. Integration i Danmark

    OpenAIRE

    Mikkelsen, Caroline; Olsen, Kristine Falk; Weng, Millie Cammilla; Andersen, Stine Bjørnstrup

    2012-01-01

    We found interest in this project, when we through the media discovered that there is a lot of prejudicesregardingimmigrants in Denmark. We saw a problem in these prejudices and wanted to get an insight in howthese prejudicesaffect the integration in Denmark, which led us to following question of reach: What are the problems about the Danish integration in relation to stigma and what part do the conquests play in the debate, regarding assimilation or integration in the Danish society. Our ...

  3. Integrated Sensitivity Analysis Workflow

    Energy Technology Data Exchange (ETDEWEB)

    Friedman-Hill, Ernest J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoffman, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gibson, Marcus J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clay, Robert L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-08-01

    Sensitivity analysis is a crucial element of rigorous engineering analysis, but performing such an analysis on a complex model is difficult and time consuming. The mission of the DART Workbench team at Sandia National Laboratories is to lower the barriers to adoption of advanced analysis tools through software integration. The integrated environment guides the engineer in the use of these integrated tools and greatly reduces the cycle time for engineering analysis.

  4. Branching trajectory continual integral

    International Nuclear Information System (INIS)

    Maslov, V.P.; Chebotarev, A.M.

    1980-01-01

    Heuristic definition of the Feynman continual integral over branching trajectories is suggested which makes it possible to obtain in the closed form the solution of the Cauchy problem for the model Hartree equation. A number of properties of the solution is derived from an integral representation. In particular, the quasiclassical asymptotics, exact solution in the gaussian case and perturbation theory series are described. The existence theorem for the simpliest continual integral over branching trajectories is proved [ru

  5. An integral heuristic

    International Nuclear Information System (INIS)

    Kauffman, L.H.

    1990-01-01

    This paper gives a heuristic derivation of the skein relation for the Homfly polynomial in an integral formalism. The derivation is formally correct but highly simplified. In the light of Witten's proposal for invariants of links via functional integrals, it is useful to have a formal pattern to compare with the complexities of the full approach. The formalism is a heuristic. However, it is closely related to the actual structure of the Witten functional integral

  6. The integrated PWR

    International Nuclear Information System (INIS)

    Gautier, G.M.

    2002-01-01

    This document presents the integrated reactors concepts by a presentation of four reactors: PIUS, SIR, IRIS and CAREM. The core conception, the operating, the safety, the economical aspects and the possible users are detailed. From the performance of the classical integrated PWR, the necessity of new innovative fuels utilization, the research of a simplified design to make easier the safety and the KWh cost decrease, a new integrated reactor is presented: SCAR 600. (A.L.B.)

  7. Modularly Integrated MEMS Technology

    National Research Council Canada - National Science Library

    Eyoum, Marie-Angie N

    2006-01-01

    Process design, development and integration to fabricate reliable MEMS devices on top of VLSI-CMOS electronics without damaging the underlying circuitry have been investigated throughout this dissertation...

  8. Handbook of integral equations

    CERN Document Server

    Polyanin, Andrei D

    2008-01-01

    This handbook contains over 2,500 integral equations with solutions as well as analytical and numerical methods for solving linear and nonlinear equations. It explores Volterra, Fredholm, WienerHopf, Hammerstein, Uryson, and other equations that arise in mathematics, physics, engineering, the sciences, and economics. This second edition includes new chapters on mixed multidimensional equations and methods of integral equations for ODEs and PDEs, along with over 400 new equations with exact solutions. With many examples added for illustrative purposes, it presents new material on Volterra, Fredholm, singular, hypersingular, dual, and nonlinear integral equations, integral transforms, and special functions.

  9. Avionics systems integration technology

    Science.gov (United States)

    Stech, George; Williams, James R.

    1988-01-01

    A very dramatic and continuing explosion in digital electronics technology has been taking place in the last decade. The prudent and timely application of this technology will provide Army aviation the capability to prevail against a numerically superior enemy threat. The Army and NASA have exploited this technology explosion in the development and application of avionics systems integration technology for new and future aviation systems. A few selected Army avionics integration technology base efforts are discussed. Also discussed is the Avionics Integration Research Laboratory (AIRLAB) that NASA has established at Langley for research into the integration and validation of avionics systems, and evaluation of advanced technology in a total systems context.

  10. Extending Database Integration Technology

    National Research Council Canada - National Science Library

    Buneman, Peter

    1999-01-01

    Formal approaches to the semantics of databases and database languages can have immediate and practical consequences in extending database integration technologies to include a vastly greater range...

  11. Integrated Information Management (IIM)

    National Research Council Canada - National Science Library

    McIlvain, Jason

    2007-01-01

    Information Technology is the core capability required to align our resources and increase our effectiveness on the battlefield by integrating and coordinating our preventative measures and responses...

  12. Building integrated photovoltaic; Photovaltaique integre aux batiments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-01-01

    Durable, modular and flexible in use, as demonstrated by the different case studies in this publication, photovoltaic can replace diverse building elements, from glass facades to weather proof roofs. This leaflet towards architects describes aesthetic, technical, economic and environmental interest of building integrated photovoltaic. (author)

  13. Wealth Through Integration: Regional Integration and Poverty ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2013-02-27

    Feb 27, 2013 ... Could regional integration be a first step toward joining the global market? Since trade liberalization reduces revenues from duties and taxes, the available resources for public investments are negatively affected. The proposed solution encourages less-developed countries to emphasize regional ...

  14. Feynman integrals and hyperlogarithms

    International Nuclear Information System (INIS)

    Panzer, Erik

    2015-01-01

    We study Feynman integrals in the representation with Schwinger parameters and derive recursive integral formulas for massless 3- and 4-point functions. Properties of analytic (including dimensional) regularization are summarized and we prove that in the Euclidean region, each Feynman integral can be written as a linear combination of convergent Feynman integrals. This means that one can choose a basis of convergent master integrals and need not evaluate any divergent Feynman graph directly. Secondly we give a self-contained account of hyperlogarithms and explain in detail the algorithms needed for their application to the evaluation of multivariate integrals. We define a new method to track singularities of such integrals and present a computer program that implements the integration method. As our main result, we prove the existence of infinite families of massless 3- and 4-point graphs (including the ladder box graphs with arbitrary loop number and their minors) whose Feynman integrals can be expressed in terms of multiple polylogarithms, to all orders in the ε-expansion. These integrals can be computed effectively with the presented program. We include interesting examples of explicit results for Feynman integrals with up to 6 loops. In particular we present the first exactly computed counterterm in massless φ 4 theory which is not a multiple zeta value, but a linear combination of multiple polylogarithms at primitive sixth roots of unity (and divided by the √(3)). To this end we derive a parity result on the reducibility of the real- and imaginary parts of such numbers into products and terms of lower depth.

  15. Factorization of Behavioral Integrity

    DEFF Research Database (Denmark)

    Li, Ximeng; Nielson, Flemming; Nielson, Hanne Riis

    2015-01-01

    We develop a bisimulation-based nonintereference property that describes the allowed dependencies between communication behaviors of different integrity levels. The property is able to capture all possible combinations of integrity levels for the “presence” and “content” of actual communications...

  16. Fuzzy measures and integrals

    Czech Academy of Sciences Publication Activity Database

    Mesiar, Radko

    2005-01-01

    Roč. 28, č. 156 (2005), s. 365-370 ISSN 0165-0114 R&D Projects: GA ČR(CZ) GA402/04/1026 Institutional research plan: CEZ:AV0Z10750506 Keywords : fuzzy measures * fuzzy integral * regular fuzzy integral Subject RIV: BA - General Mathematics Impact factor: 1.039, year: 2005

  17. Hermeneutics of Integrative Knowledge.

    Science.gov (United States)

    Shin, Un-chol

    This paper examines and compares the formation processes and structures of three types of integrative knowledge that in general represent natural sciences, social sciences, and humanities. These three types can be observed, respectively, in the philosophies of Michael Polanyi, Jurgen Habermas, and Paul Ricoeur. These types of integrative knowledge…

  18. Ramjets: Airframe Integration

    Science.gov (United States)

    2010-09-01

    Thermal Management (Propulsion a vitesse elevee : Conception du moteur - integration et gestion thermique ) 14. ABSTRACT These notes deal with the...analogy for heat transfer from the outer flow to the conical intake shell via the Ramjets: Airframe Integration 6 - 24 RTO-EN-AVT-185 boundary

  19. Integrated Marketing Communications

    Science.gov (United States)

    Black, Jim

    2004-01-01

    Integration has become a cliche in enrollment management and student services circles. The term is used to describe everything from integrated marketing to seamless services. Often, it defines organizational structures, processes, student information systems, and even communities. In Robert Sevier's article in this issue of "College and…

  20. Integration and Polar Coordinates

    Indian Academy of Sciences (India)

    Jacobian matrix, Riemann- integrable function, co-area for- mula, Lipschitzfunction, levelset. S Kesavan. A simple proof of the formula for the integration of radial functions on R", N > 2, is given. As an application, the volume of the N-dimensional unit ball is computed. 1. Introduction. The method of substitution, also known as ...

  1. Integration Report 2007

    NARCIS (Netherlands)

    Jaco Dagevos; Mérove Gijsberts

    2007-01-01

    Original title: Jaarrapport integratie 2007. The Annual Report on Integration 2007 describes the integration of non-Western ethnic minorities in the Netherlands using a wide range of indicators. It focuses among other things on the situation of ethnic minority pupils in education, the

  2. On an integral transform

    Directory of Open Access Journals (Sweden)

    D. Naylor

    1986-01-01

    Full Text Available This paper establishes properties of a convolution type integral transform whose kernel is a Macdonald type Bessel function of zero order. An inversion formula is developed and the transform is applied to obtain the solution of some related integral equations.

  3. Integral fast reactor concept

    International Nuclear Information System (INIS)

    Chang, Y.I.; Marchaterre, J.F.; Sevy, R.H.

    1984-01-01

    Key features of the IFR consist of a pool-type plant arrangement, a metal fuel-based core design, and an integral fuel cycle with colocated fuel cycle facility. Both the basic concept and the technology base have been demonstrated through actual integral cycle operation in EBR-II. This paper discusses the inherent safety characteristics of the IFR concept

  4. The Fresnel Integrals Revisited

    Science.gov (United States)

    Chen, Hongwei

    2009-01-01

    This note presents another elementary method to evaluate the Fresnel integrals. It is interesting to see that this technique is also strong enough to capture a number of pairs of parameter integrals. The main ingredients of the method are the consideration of some related derivatives and linear differential equations.

  5. Hamiltonian path integrals

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1982-01-01

    The properties of path integrals associated with the allowance for nonstandard terms reflecting the operator nature of the canonical variables are considered. Rules for treating such terms (''equivalence rules'') are formulated. Problems with a boundary, the behavior of path integrals under canonical transformations, and the problem of quantization of dynamical systems with constraints are considered in the framework of the method

  6. Integrity, Concept of

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    Integrity can be defined in the following sense: Integrity accounts for the inviolability of the human being. Although originally a virtue of uncorrupted character, expressing uprightness, honesty, and good intentions, it has, like dignity, been universalized as a quality of the person as such. T...

  7. Integral transformational coaching

    NARCIS (Netherlands)

    Keizer, W.A.J.; Nandram, S.S.

    2009-01-01

    In Chap. 12, Keizer and Nandram present the concept of Integral Transformational Coaching based on the concept of Flow and its effects on work performance. Integral Transformational Coaching is a method that prevents and cures unhealthy stress and burnout. They draw on some tried and tested

  8. Integration i flere variable

    DEFF Research Database (Denmark)

    Markvorsen, Steen

    2010-01-01

    -integralerne. Undervejs introduceres \\texttt{Integrator8}. Det er en pakke med Maple procedurer, som er udviklet specielt med henblik på eksempelbaseret visuel læring af de indledende integrationsbegreber og deres mangfoldige anvendelser. Vi giver eksempler på, hvordan integration i flere variable anvendes til beregning...

  9. Musik, Sprog og Integration

    DEFF Research Database (Denmark)

    Holst, Finn

    2010-01-01

    Evaluering af projektet Musik, Sprog og Integration, Søndermarkskolen, Horsens. Andenårsevaluering af et treårigt projekt.......Evaluering af projektet Musik, Sprog og Integration, Søndermarkskolen, Horsens. Andenårsevaluering af et treårigt projekt....

  10. Kanonisk sikkerhed og integration

    DEFF Research Database (Denmark)

    Larsen, Vibe; Øland, Trine

    2006-01-01

    Artiklen diskuterer, med indragelse af den lignende debat i andre europæiske lande, kulturkanonen i forhold til integration......Artiklen diskuterer, med indragelse af den lignende debat i andre europæiske lande, kulturkanonen i forhold til integration...

  11. Does energy integrate?

    Energy Technology Data Exchange (ETDEWEB)

    Hira, A.; Amaya, L. [Simon Fraser University, Burnaby, BC (Canada). Dept. of Political Science

    2003-01-01

    Amidst the international movement to privatize and deregulate electricity and gas sectors of economics, the question of the integration of those sectors has been somewhat underestimated. In fact, the integration of energy markets across boundaries is occurring. We examine this process in three regions: Europe, Central America, and South America. We analyze the forces driving integration in each area, and estimate the prospects for progress. We take a close look at Nordpool, which is now the most integrated market in the world, to see if it can serve as a model for other regions. We close with a set of conditions that we suggest are necessary for a successful international integration of energy markets. (author)

  12. Does energy integrate?

    International Nuclear Information System (INIS)

    Hira, Anil; Amaya, Libardo

    2003-01-01

    Amidst the international movement to privatize and deregulate electricity and gas sectors of economies, the question of the integration of those sectors has been somewhat underestimated. In fact, the integration of energy markets across boundaries is occurring. We examine this process in three regions: Europe, Central America, and South America. We analyze the forces driving integration in each area, and estimate the prospects for progress. We take a close look at Nordpool, which is now the most integrated market in the world, to see if it can serve as a model for other regions. We close with a set of conditions that we suggest are necessary for a successful international integration of energy markets

  13. Laboring for integration

    DEFF Research Database (Denmark)

    Fogelman, Tatiana

    Over the past fifteen years the district of Berlin-Marzahn became home to the largest concentration of post-Soviet migrants of German ancestry in the former East Germany. Drawing on my research in the district, including two of its integration projects for middle-aged, unemployed migrants, I...... examine these projects’ failed attempts to create spaces of encounter between the migrants and district’s long-term residents. In this presentation I focus specifically on the structural position of integration work (Integrationsarbeit) that creates first and foremost conditions of possibility for its...... temporal imaginaries underpinning the ideas of integration through encounter, as well as integration more broadly, I argue for reflexivity-centric public reformulations of both integration and encounter....

  14. Personal Integrity and Leadership

    Directory of Open Access Journals (Sweden)

    Antonius Gea

    2016-07-01

    Full Text Available Generally, integrity is associated with leadership, especially in the organization or company. Integrity in leadership becomes a growing concern in business and organizations. The aim of this study was to find out the connection that could be shaped between personal integrity and the skill of leadership especially in the performance of work. This study used a library research, a literature study that done by using the available resources and relevant literature, related to the topic being discussed by the author. Books or journal articles related to topics were used as background reading to understand well about the problems of integrity and leadership, especially in the organization or company. This study finds out that the leader integrity is related to follower work role performance and that this effect is fully mediated through follower affective organizational commitment. 

  15. Neuroeconomics and Integrated Care

    DEFF Research Database (Denmark)

    Larsen, Torben

    2012-01-01

    Background: Fragmented specialized care for the frail elderly as claimed by WHO needs horizontal integration across settings. The home of the patient seems to be a promising place to integrate hospital care, primary care and social services for high-risk discharges where the quality...... of rehabilitation makes a difference. Objective: The study aims to reveal how integrated home care may be organised to improve quality of care as compared to usual hospital care. Method: A qualitative case study of the use of a neuroeconomic model in relation to multidisciplianry collaboration on a RCT...... of integrated home care for stroke patients. Results: (1) The classical understanding of CNS is that of a dual system of ANS and Cortex. The new neuroeconomic understanding is that of a reciprocal balance of Limbic System (LS) and Neocortex (NC). This applies directly in favour of integrated homecare compared...

  16. Retroviral integration: Site matters

    Science.gov (United States)

    Demeulemeester, Jonas; De Rijck, Jan

    2015-01-01

    Here, we review genomic target site selection during retroviral integration as a multistep process in which specific biases are introduced at each level. The first asymmetries are introduced when the virus takes a specific route into the nucleus. Next, by co‐opting distinct host cofactors, the integration machinery is guided to particular chromatin contexts. As the viral integrase captures a local target nucleosome, specific contacts introduce fine‐grained biases in the integration site distribution. In vivo, the established population of proviruses is subject to both positive and negative selection, thereby continuously reshaping the integration site distribution. By affecting stochastic proviral expression as well as the mutagenic potential of the virus, integration site choice may be an inherent part of the evolutionary strategies used by different retroviruses to maximise reproductive success. PMID:26293289

  17. Vertcal integration: origins of oil industry integration

    International Nuclear Information System (INIS)

    Rainbow, R.

    2001-01-01

    This article examines the structure of the US oil industry in relation to the history of the industry, capital market assumptions, and advice on the enhancement of 'shareholder value'. The driving forces behind the attempts to establish cartels and vertical integration are considered, and the emergence of US companies resulting from the break-up of the Standard Oil Trust cartel, the influence of costs and logistics on the structure of the industry outside the USA , and the structure of the natural gas industry are discussed along with the discovery of large Middle East oil reserves, the enormous growth in demand for oil products in Europe and Japan, and the formation of the OPEC cartel. Details are given of the breaking down of vertical integration in the big oil companies, the theory of conglomerates, the success of big companies, the importance of scale to balance exploration risks, and the need to adjust in time to shifts in the business environment

  18. Long Pulse Integrator of Variable Integral Time Constant

    International Nuclear Information System (INIS)

    Wang Yong; Ji Zhenshan; Du Xiaoying; Wu Yichun; Li Shi; Luo Jiarong

    2010-01-01

    A kind of new long pulse integrator was designed based on the method of variable integral time constant and deducting integral drift by drift slope. The integral time constant can be changed by choosing different integral resistors, in order to improve the signal-to-noise ratio, and avoid output saturation; the slope of integral drift of a certain period of time can be calculated by digital signal processing, which can be used to deduct the drift of original integral signal in real time to reduce the integral drift. The tests show that this kind of long pulse integrator is good at reducing integral drift, which also can eliminate the effects of changing integral time constant. According to experiments, the integral time constant can be changed by remote control and manual adjustment of integral drift is avoided, which can improve the experiment efficiency greatly and can be used for electromagnetic measurement in Tokamak experiment. (authors)

  19. Integrated assessment briefs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Integrated assessment can be used to evaluate and clarify resource management policy options and outcomes for decision makers. The defining characteristics of integrated assessment are (1) focus on providing information and analysis that can be understood and used by decision makers rather than for merely advancing understanding and (2) its multidisciplinary approach, using methods, styles of study, and considerations from a broader variety of technical areas than would typically characterize studies produced from a single disciplinary standpoint. Integrated assessment may combine scientific, social, economic, health, and environmental data and models. Integrated assessment requires bridging the gap between science and policy considerations. Because not everything can be valued using a single metric, such as a dollar value, the integrated assessment process also involves evaluating trade-offs among dissimilar attributes. Scientists at Oak Ridge National Laboratory (ORNL) recognized the importance and value of multidisciplinary approaches to solving environmental problems early on and have pioneered the development of tools and methods for integrated assessment over the past three decades. Major examples of ORNL`s experience in the development of its capabilities for integrated assessment are given.

  20. Three dimensional system integration

    CERN Document Server

    Papanikolaou, Antonis; Radojcic, Riko

    2010-01-01

    Three-dimensional (3D) integrated circuit (IC) stacking is the next big step in electronic system integration. It enables packing more functionality, as well as integration of heterogeneous materials, devices, and signals, in the same space (volume). This results in consumer electronics (e.g., mobile, handheld devices) which can run more powerful applications, such as full-length movies and 3D games, with longer battery life. This technology is so promising that it is expected to be a mainstream technology a few years from now, less than 10-15 years from its original conception. To achieve thi

  1. In times of Integration

    DEFF Research Database (Denmark)

    Val, Maria Rosa Rovira; Lehmann, Martin; Zinenko, Anna

    dramatically with many of the world’s economies facing downturn and a looming possible recession; and the global economic and political balance changing; (ii) most larger companies and quite a few SMEs now have a mature knowledge of these standards; and (iii) some standards are advocating for integration...... procedures, such as cases of for example ISO integrated management systems, mutual equivalences recognition of Global Compact-GRI-ISO26000, or the case of IIRC initiative to develop integrated reporting on an organization’s Financial, Environmental, Social and Governance performance. This paper focuses...

  2. SQL Server Integration Services

    CERN Document Server

    Hamilton, Bill

    2007-01-01

    SQL Server 2005 Integration Services (SSIS) lets you build high-performance data integration solutions. SSIS solutions wrap sophisticated workflows around tasks that extract, transform, and load (ETL) data from and to a wide variety of data sources. This Short Cut begins with an overview of key SSIS concepts, capabilities, standard workflow and ETL elements, the development environment, execution, deployment, and migration from Data Transformation Services (DTS). Next, you'll see how to apply the concepts you've learned through hands-on examples of common integration scenarios. Once you've

  3. Social integration i arbejdslivet

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Christensen, Allan

    2002-01-01

    of the study that social integration depends on working environment conditions as well as cultural conditions. The social integration again is crucial for the way in which employees perceive the daily work situation and indirectly also for the well-being of the clients of the institution.......The study reported in this article is based on a combination of methods related to working environment and to organisational culture. The combination is aimed at studying the extent and meaning of the social integration of the employees in an institution for handicapped adults. It is the conclusion...

  4. Improper Riemann integrals

    CERN Document Server

    Roussos, Ioannis Markos

    2013-01-01

    Improper Riemann Integrals is the first book to collect classical and modern material on the subject for undergraduate students. The book gives students the prerequisites and tools to understand the convergence, principal value, and evaluation of the improper/generalized Riemann integral. It also illustrates applications to science and engineering problems.The book contains the necessary background, theorems, and tools, along with two lists of the most important integrals and sums computed in the text. Numerous examples at various levels of difficulty illustrate the concepts and theorems. The

  5. The Structural Integrity Centre

    International Nuclear Information System (INIS)

    Tomkins, B.

    1987-01-01

    The paper concerns the development and work of the Structural Integrity Centre (SIC) at Risley Nuclear Laboratories, United Kingdom. The centre was set up to provide authoritative advice to plant designers and operators on the integrity and life assessment of structures and components across the reactor projects in the United Kingdom. A description is given of the structure and role of the SIC, as well as the Structural Integrity Assessment work. The assessment methods are described for thermally loaded structures and welded structures. Finally, defect significance assessment and environmental effects are outlined. (U.K.)

  6. Principles of data integration

    CERN Document Server

    Doan, AnHai; Ives, Zachary

    2012-01-01

    How do you approach answering queries when your data is stored in multiple databases that were designed independently by different people? This is first comprehensive book on data integration and is written by three of the most respected experts in the field. This book provides an extensive introduction to the theory and concepts underlying today's data integration techniques, with detailed, instruction for their application using concrete examples throughout to explain the concepts. Data integration is the problem of answering queries that span multiple data sources (e.g., databases, web

  7. MOS integrated circuit design

    CERN Document Server

    Wolfendale, E

    2013-01-01

    MOS Integral Circuit Design aims to help in the design of integrated circuits, especially large-scale ones, using MOS Technology through teaching of techniques, practical applications, and examples. The book covers topics such as design equation and process parameters; MOS static and dynamic circuits; logic design techniques, system partitioning, and layout techniques. Also featured are computer aids such as logic simulation and mask layout, as well as examples on simple MOS design. The text is recommended for electrical engineers who would like to know how to use MOS for integral circuit desi

  8. Path integration quantization

    International Nuclear Information System (INIS)

    DeWitt-Morette, C.

    1983-01-01

    Much is expected of path integration as a quantization procedure. Much more is possible if one recognizes that path integration is at the crossroad of stochastic and differential calculus and uses the full power of both stochastic and differential calculus in setting up and computing path integrals. In contrast to differential calculus, stochastic calculus has only comparatively recently become an instrument of thought. It has nevertheless already been used in a variety of challenging problems, for instance in the quantization problem. The author presents some applications of the stochastic scheme. (Auth.)

  9. GMRES and integral operators

    Energy Technology Data Exchange (ETDEWEB)

    Kelley, C.T.; Xue, Z.Q. [North Carolina State Univ., Raleigh, NC (United States)

    1994-12-31

    Many discretizations of integral equations and compact fixed point problems are collectively compact and strongly convergent in spaces of continuous functions. These properties not only lead to stable and convergent approximations but also can be used in the construction of fast multilevel algorithms. Recently the GMRES algorithm has become a standard coarse mesh solver. The purpose of this paper is to show how the special properties of integral operators and their approximations are reflected in the performance of the GMRES iteration and how these properties can be used to strengthen the norm in which convergence takes place. The authors illustrate these ideas with composite Gauss rules for integral equations on the unit interval.

  10. Hamiltonian path integrals

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1982-01-01

    Problems related to consideration of operator nonpermutability in Hamiltonian path integral (HPI) are considered in the review. Integrals are investigated using trajectories in configuration space (nonrelativistic quantum mechanics). Problems related to trajectory integrals in HPI phase space are discussed: the problem of operator nonpermutability consideration (extra terms problem) and corresponding equivalence rules; ambiguity of HPI usual recording; transition to curvilinear coordinates. Problem of quantization of dynamical systems with couplings has been studied. As in the case of canonical transformations, quantization of the systems with couplings of the first kind requires the consideration of extra terms

  11. Introduction to integral discriminants

    International Nuclear Information System (INIS)

    Morozov, A.; Shakirov, Sh.

    2009-01-01

    The simplest partition function, associated with homogeneous symmetric forms S of degree r in n variables, is integral discriminant J n|r (S) = ∫e -S(x 1 ,...,x n ) dx 1 ...dx n . Actually, S-dependence remains the same if e -S in the integrand is substituted by arbitrary function f(S), i.e. integral discriminant is a characteristic of the form S itself, and not of the averaging procedure. The aim of the present paper is to calculate J n|r in a number of non-Gaussian cases. Using Ward identities - linear differential equations, satisfied by integral discriminants - we calculate J 2|3 ,J 2|4 ,J 2|5 and J 3|3 . In all these examples, integral discriminant appears to be a generalized hypergeometric function. It depends on several SL(n) invariants of S, with essential singularities controlled by the ordinary algebraic discriminant of S.

  12. Financial Integrity Benchmarks

    Data.gov (United States)

    City of Jackson, Mississippi — This data compiles standard financial integrity benchmarks that allow the City to measure its financial standing. It measure the City's debt ratio and bond ratings....

  13. Immigration und Integration

    OpenAIRE

    Rauscher, Anton

    2003-01-01

    Immigration und Integration : eine Herausforderung für Kirche, Gesellschaft und Politik in Deutschland und den USA / hrsg. von Anton Rauscher. - Berlin : Duncker & Humblot, 2003. - 174 S. - (Soziale Orientierung ; 15)

  14. Integrated Health Management Definitions

    Data.gov (United States)

    National Aeronautics and Space Administration — The Joint Army Navy NASA Air Force Modeling and Simulation Subcommittee's Integrated Health Management panel was started about 6 years ago to help foster...

  15. Integrated Disposal Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Located near the center of the 586-square-mile Hanford Site is the Integrated Disposal Facility, also known as the IDF.This facility is a landfill similar in concept...

  16. Measuring integrated care

    DEFF Research Database (Denmark)

    Strandberg-Larsen, Martin

    2011-01-01

    differences were found in the perception of clinical integration in the two settings. More primary care clinicians in the Northern California region of Kaiser Permanente reported being part of a clinical integrated environment than did Danish general practitioners. By measuring the level of clinical...... respond to these needs, patients and providers face the multiple challenges of today's healthcare environment. Decision makers, planners and managers need evidence based policy options and information on the scope of the integrated care challenges they are facing. The US managed care organization Kaiser...... Permanente has been put forward as an example for European healthcare systems to follow, although the evidence base is far from conclusive. The thesis has five objectives: 1) To contribute to the understanding of the concept of integration in healthcare systems and to identify measurement methods to capture...

  17. Integrating Forensic Science.

    Science.gov (United States)

    Funkhouser, John; Deslich, Barbara J.

    2000-01-01

    Explains the implementation of forensic science in an integrated curriculum and discusses the advantages of this approach. Lists the forensic science course syllabi studied in three high schools. Discusses the unit on polymers in detail. (YDS)

  18. State Program Integrity Reviews

    Data.gov (United States)

    U.S. Department of Health & Human Services — State program integrity reviews play a critical role in how CMS provides effective support and assistance to states in their efforts to combat provider fraud and...

  19. Advances in integrated optics

    CERN Document Server

    Chester, A; Bertolotti, M

    1994-01-01

    This volwne contains the Proceedings of a two-week summer conference titled "Advances in Integrated Optics" held June 1-9, 1993, in Erice, Sicily. This was the 18th annual course organized by the International School of Quantum Electronics, under the auspices of the "Ettore Majorana" Centre for Scientific Culture. The term Integrated Optics signifies guided-wave optical circuits consisting of two or more devices on a single substrate. Since its inception in the late 1960's, Integrated Optics has evolved from a specialized research topic into a broad field of work, ranging from basic research through commercial applications. Today many devices are available on market while a big effort is devolved to research on integrated nonlinear optical devices. This conference was organized to provide a comprehensive survey of the frontiers of this technology, including fundamental concepts, nonlinear optical materials, devices both in the linear and nonlinear regimes, and selected applications. These Proceedings update a...

  20. Integrated Surface Dataset (Global)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Integrated Surface (ISD) Dataset (ISD) is composed of worldwide surface weather observations from over 35,000 stations, though the best spatial coverage is...

  1. Integration, measure and probability

    CERN Document Server

    Pitt, H R

    2012-01-01

    Introductory treatment develops the theory of integration in a general context, making it applicable to other branches of analysis. More specialized topics include convergence theorems and random sequences and functions. 1963 edition.

  2. European Economic Integration

    Science.gov (United States)

    Huston, James A.

    1971-01-01

    Recounts the history and problems of European Economic Integration from the first post World War II organization, the OEEC, to the EEC (Common Market) and the EFTA. Suggestions for further reading are included. (JB)

  3. Integrals of Bessel functions

    OpenAIRE

    Babusci, D.; Dattoli, G.; Germano, B.; Martinelli, M. R.; Ricci, P. E.

    2011-01-01

    We use the operator method to evaluate a class of integrals involving Bessel or Bessel-type functions. The technique we propose is based on the formal reduction of these family of functions to Gaussians.

  4. Integrated inventory information system

    Digital Repository Service at National Institute of Oceanography (India)

    Sarupria, J.S.; Kunte, P.D.

    The nature of oceanographic data and the management of inventory level information are described in Integrated Inventory Information System (IIIS). It is shown how a ROSCOPO (report on observations/samples collected during oceanographic programme...

  5. Measuring integrated care

    DEFF Research Database (Denmark)

    Strandberg-Larsen, Martin

    2011-01-01

    respond to these needs, patients and providers face the multiple challenges of today's healthcare environment. Decision makers, planners and managers need evidence based policy options and information on the scope of the integrated care challenges they are facing. The US managed care organization Kaiser...... Permanente has been put forward as an example for European healthcare systems to follow, although the evidence base is far from conclusive. The thesis has five objectives: 1) To contribute to the understanding of the concept of integration in healthcare systems and to identify measurement methods to capture...... the multi-dimensional aspects of integrated healthcare delivery. 2) To assess the level of integration of the Danish healthcare system. 3) To assess the use of joint health plans as a tool for coordination between the regional and local level in the Danish healthcare system. 4) To compare the inputs...

  6. Integration a functional approach

    CERN Document Server

    Bichteler, Klaus

    1998-01-01

    This book covers Lebesgue integration and its generalizations from Daniell's point of view, modified by the use of seminorms. Integrating functions rather than measuring sets is posited as the main purpose of measure theory. From this point of view Lebesgue's integral can be had as a rather straightforward, even simplistic, extension of Riemann's integral; and its aims, definitions, and procedures can be motivated at an elementary level. The notion of measurability, for example, is suggested by Littlewood's observations rather than being conveyed authoritatively through definitions of (sigma)-algebras and good-cut-conditions, the latter of which are hard to justify and thus appear mysterious, even nettlesome, to the beginner. The approach taken provides the additional benefit of cutting the labor in half. The use of seminorms, ubiquitous in modern analysis, speeds things up even further. The book is intended for the reader who has some experience with proofs, a beginning graduate student for example. It might...

  7. Systems Integration Fact Sheet

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    This fact sheet is an overview of the Systems Integration subprogram at the U.S. Department of Energy SunShot Initiative. The Systems Integration subprogram enables the widespread deployment of safe, reliable, and cost-effective solar energy technologies by addressing the associated technical and non-technical challenges. These include timely and cost-effective interconnection procedures, optimal system planning, accurate prediction of solar resources, monitoring and control of solar power, maintaining grid reliability and stability, and many more. To address the challenges associated with interconnecting and integrating hundreds of gigawatts of solar power onto the electricity grid, the Systems Integration program funds research, development, and demonstration projects in four broad, interrelated focus areas: grid performance and reliability, dispatchability, power electronics, and communications.

  8. The Executive as Integrator.

    Science.gov (United States)

    Cohn, Hans M.

    1983-01-01

    Argues that although the executive has many tasks, he or she must view internal organizational integration as a primary task, making use of organizational charts, job descriptions, statements of goals and objectives, evaluations, and feedback devices. (RH)

  9. On Kontsevich integrals

    International Nuclear Information System (INIS)

    Itzykson, C.

    1992-01-01

    Some mathematical results are described on a remarkable application of matrix interaction due to Witten and Kontsevich, to study topological invariants. Some interesting properties of the Kontsevich integrals are identified. (K.A.) 4 refs

  10. Pair Correlation Function Integrals

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar; O'Connell, John P.; Peters, Günther H.J.

    2011-01-01

    We describe a method for extending radial distribution functions obtained from molecular simulations of pure and mixed molecular fluids to arbitrary distances. The method allows total correlation function integrals to be reliably calculated from simulations of relatively small systems. The long-d...... distribution function has structure beyond the sampling limit imposed by the system size, the integration is more reliable, and usually more accurate, than simple integral truncation.......We describe a method for extending radial distribution functions obtained from molecular simulations of pure and mixed molecular fluids to arbitrary distances. The method allows total correlation function integrals to be reliably calculated from simulations of relatively small systems. The long......, and J. Abildskov, Mol. Simul. 36, 1243 (2010); Fluid Phase Equilib. 302, 32 (2011)], but describe here its theoretical basis more thoroughly and derive long-distance approximations for the direct correlation functions. We describe the numerical implementation of the method in detail, and report...

  11. Introduction to integral discriminants

    Science.gov (United States)

    Morozov, A.; Shakirov, Sh.

    2009-12-01

    The simplest partition function, associated with homogeneous symmetric forms S of degree r in n variables, is integral discriminant Jn|r(S) = ∫e-S(x1,...,xn)dx1...dxn. Actually, S-dependence remains the same if e-S in the integrand is substituted by arbitrary function f(S), i.e. integral discriminant is a characteristic of the form S itself, and not of the averaging procedure. The aim of the present paper is to calculate Jn|r in a number of non-Gaussian cases. Using Ward identities — linear differential equations, satisfied by integral discriminants — we calculate J2|3,J2|4,J2|5 and J3|3. In all these examples, integral discriminant appears to be a generalized hypergeometric function. It depends on several SL(n) invariants of S, with essential singularities controlled by the ordinary algebraic discriminant of S.

  12. Retroviral DNA Integration

    Science.gov (United States)

    2016-01-01

    The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via two integrase activities: 3′-processing of the viral DNA ends, followed by the strand transfer of the processed ends into host cell chromosomal DNA. Herein we review the molecular mechanism of retroviral DNA integration, with an emphasis on reaction chemistries and architectures of the nucleoprotein complexes involved. We additionally discuss the latest advances on anti-integrase drug development for the treatment of AIDS and the utility of integrating retroviral vectors in gene therapy applications. PMID:27198982

  13. Complementary and Integrative Medicine

    Science.gov (United States)

    ... medical treatments that are not part of mainstream medicine. When you are using these types of care, it may be called complementary, integrative, or alternative medicine. Complementary medicine is used together with mainstream medical ...

  14. Integrated Reporting Information System -

    Data.gov (United States)

    Department of Transportation — The Integrated Reporting Information System (IRIS) is a flexible and scalable web-based system that supports post operational analysis and evaluation of the National...

  15. Integrating corpora and dictionaries

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2012-01-01

    In this paper, we will discuss different possibilities for integration of corpus data with dictionary data, mainly seen from a lexicographic point of view and in a sign language context. For about 25 years a text corpus has been considered a useful, if not necessary tool for editing dictionaries...... of written and spoken languages. Corpora are equally useful to sign language lexicographers, but sign language corpora have not become accessible until recent years. Nowadays corpora exist, or are being developed, for several sign languages, and we have the possibility of editing new, truly corpus-based sign...... language dictionaries, and of developing interfaces that integrate corpus and dictionary data. After a brief look at three existing integrated interfaces, one for German, one for Danish, and one for Danish Sign Language, we point out some of the problems that should be considered when making an integrated...

  16. Penitentiary integral defense

    OpenAIRE

    Francisco Javier Rodríguez Román

    2012-01-01

    Penitentiary integral defense is a set of techniques designed to solve the breach of the peace that may appear in the penitentiary world. This paper studies the scope and legal framework of penitentiary self-defense. This kind of self-defense is defined by the particular characteristics of a confinement context and a very specific regulation aimed at preserving the integrity of prisoners and penitentiary staff as well as prison facilities. A technical section illustrating the main penitentiar...

  17. Integrated parasite management

    DEFF Research Database (Denmark)

    Clausen, Jesper Hedegaard; Madsen, Henry; Van, Phan Thi

    2015-01-01

    communities at risk through mass drug administration. However, we argue that treatment alone will not reduce the risk from eating infected fish and that sustainable effective control must adopt an integrated FZT control approach based on education, infrastructure improvements, and management practices...... that target critical control points in the aquaculture production cycle identified from a thorough understanding of FZT and host biology and epidemiology. We present recommendations for an integrated parasite management (IPM) program for aquaculture farms....

  18. IDC Integrated Master Plan.

    Energy Technology Data Exchange (ETDEWEB)

    Clifford, David J.; Harris, James M.

    2014-12-01

    This is the IDC Re-Engineering Phase 2 project Integrated Master Plan (IMP). The IMP presents the major accomplishments planned over time to re-engineer the IDC system. The IMP and the associate Integrated Master Schedule (IMS) are used for planning, scheduling, executing, and tracking the project technical work efforts. REVISIONS Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Re- engineering Project Team Initial delivery M. Harris

  19. Function integrated track system

    OpenAIRE

    Hohnecker, Eberhard

    2010-01-01

    The paper discusses a function integrated track system that focuses on the reduction of acoustic emissions from railway lines. It is shown that the combination of an embedded rail system (ERS), a sound absorbing track surface, and an integrated mini sound barrier has significant acoustic advantages compared to a standard ballast superstructure. The acoustic advantages of an embedded rail system are particularly pronounced in the case of railway bridges. Finally, it is shown that a...

  20. Writing against integration

    DEFF Research Database (Denmark)

    Rytter, Mikkel

    2018-01-01

    The article addresses some of the problems related to the concept of integration, which has been used (and abused) in Denmark since the 1980s to discuss socio-economic, cultural and religious challenges related to the everyday life of ethnic minorities. The concept of integration is not innocent,......-Lughod’s seminal article “writing against culture”, the article suggests strategies of “writing against integration” in order to regain the critical potential of academic analysis....

  1. Holomorphic matrix integrals

    International Nuclear Information System (INIS)

    Felder, Giovanni; Riser, Roman

    2004-01-01

    We study a class of holomorphic matrix models. The integrals are taken over middle-dimensional cycles in the space of complex square matrices. As the size of the matrices tends to infinity, the distribution of eigenvalues is given by a measure with support on a collection of arcs in the complex planes. We show that the arcs are level sets of the imaginary part of a hyperelliptic integral connecting branch points

  2. Integrated Electric Gas Turbine

    OpenAIRE

    Millsaps, Knox T.

    2010-01-01

    Patent An integrated electric gas turbine comprises a compressor that includes a plurality of airfoils. An electric motor is arranged to drive the compressor, and a combustor is arranged to receive compressed air from the compressor and further arranged to receive a fuel input. A turbine is arranged to receive the combustion gases from the combustor. A generator is integrated with the turbine and arranged to provide a power output. A controller is connected between the...

  3. Discrete pseudo-integrals

    Czech Academy of Sciences Publication Activity Database

    Mesiar, Radko; Li, J.; Pap, E.

    2013-01-01

    Roč. 54, č. 3 (2013), s. 357-364 ISSN 0888-613X R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : concave integral * pseudo-addition * pseudo- multiplication Subject RIV: BA - General Mathematics Impact factor: 1.977, year: 2013 http://library.utia.cas.cz/separaty/2013/E/mesiar-discrete pseudo-integrals. pdf

  4. Experimental integrated photovoltaic systems

    International Nuclear Information System (INIS)

    Pop-Jordanov, Jordan; Markovska, Natasha; Dimitrov, D.; Kocev, K.; Dimitrovski, D.

    2000-01-01

    Recently, the interest in building-integrated photovoltaic installations has started to increase within governmental and municipality authorities, as well as some industrial companies. To serve a national public-awareness program of solar electricity promotion and education, the indigenous solar energy potential, optimization of possible PV installation, and three test cases of building-integrated grid-connected experimental facilities have been studied. The results showed the feasibility and performance of the proposed concepts. (Original)

  5. Agroecology : integration with livestock

    OpenAIRE

    Tichit, Muriel; Lecompte, Philippe; Dumont, Bertrand

    2014-01-01

    Livestock systems are a large global asset contributing to food security and poverty alleviation, but livestock supply chains have major environmental impacts at global scale. The scientific literature on agroecology has not yet integrated livestock systems; only 5 percent of the indexed studies concerning agroecology deal with livestock. Following Dumont et al. (2013), we review five principles for integrating livestock systems within the agroecology debate: (i) adopting management practices...

  6. HETEROGENEOUS INTEGRATION TECHNOLOGY

    Science.gov (United States)

    2017-08-24

    9.1.1 FET- BT -HBT Integration........................................................................................... 22 9.1.2 Early GaAs-Si...Fabricated with Different Device Types on Separate Chips are Combined on the Same Chip in 2D SoC [26] 9.1.1 FET- BT -HBT Integration The semiconductor...electronics started with the use of bipolar transistors ( BTs ) but field effect transistors (FETs) were later introduced for digital applications. As

  7. Heterogeneous Integration Technology

    Science.gov (United States)

    2017-05-19

    This type of packaging is used in mobile products where because of space saving features and can be found in smart phones and tables. Figure 69...picture of 8-strata stacked chips with TSVs on interposer layer [128]. ............................. 59 Figure 72: The DARPA SMART program: (a...mounted die is integrated with another package containing stacked chips with bond wire connections [153]. PoP integration is also used heavily in smart

  8. Functional integration over geometries

    International Nuclear Information System (INIS)

    Mottola, E.

    1995-01-01

    The geometric construction of the functional integral over coset spaces M/G is reviewed. The inner product on the cotangent space of infinitesimal deformations of M defines an invariant distance and volume form, or functional integration measure on the full configuration space. Then, by a simple change of coordinates parameterizing the gauge fiber G, the functional measure on the coset space M/G is deduced. This change of integration variables leads to a Jacobian which is entirely equivalent to the Faddeev--Popov determinant of the more traditional gauge fixed approach in non-abelian gauge theory. If the general construction is applied to the case where G is the group of coordinate reparameterizations of spacetime, the continuum functional integral over geometries, i.e. metrics modulo coordinate reparameterizations may be defined. The invariant functional integration measure is used to derive the trace anomaly and effective action for the conformal part of the metric in two and four dimensional spacetime. In two dimensions this approach generates the Polyakov--Liouville action of closed bosonic non-critical string theory. In four dimensions the corresponding effective action leads to novel conclusions on the importance of quantum effects in gravity in the far infrared, and in particular, a dramatic modification of the classical Einstein theory at cosmological distance scales, signaled first by the quantum instability of classical de Sitter spacetime. Finite volume scaling relations for the functional integral of quantum gravity in two and four dimensions are derived, and comparison with the discretized dynamical triangulation approach to the integration over geometries are discussed. Outstanding unsolved problems in both the continuum definition and the simplicial approach to the functional integral over geometries are highlighted

  9. Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors : studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

    NARCIS (Netherlands)

    van Rossum, AGSH; van Bragt, MPA; Scholtes, ES; van der Ploeg, JCM; van Krieken, JHJM; Kluin, PM; Schuuring, E

    2006-01-01

    Background: In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because overexpression of both proteins, respectively cyclin D1

  10. Integrated smart structures wingbox

    Science.gov (United States)

    Simon, Solomon H.

    1993-09-01

    One objective of smart structures development is to demonstrate the ability of a mechanical component to monitor its own structural integrity and health. Achievement of this objective requires the integration of different technologies, i.e.: (1) structures, (2) sensors, and (3) artificial intelligence. We coordinated a team of experts from these three fields. These experts used reliable knowledge towards the forefront of their technologies and combined the appropriate features into an integrated hardware/software smart structures wingbox (SSW) test article. A 1/4 in. hole was drilled into the SSW test article. Although the smart structure had never seen damage of this type, it correctly recognized and located the damage. Based on a knowledge-based simulation, quantification and assessment were also carried out. We have demonstrated that the SSW integrated hardware & software test article can perform six related functions: (1) identification of a defect; (2) location of the defect; (3) quantification of the amount of damage; (4) assessment of performance degradation; (5) continued monitoring in spite of damage; and (6) continuous recording of integrity data. We present the successful results of the integrated test article in this paper, along with plans for future development and deployment of the technology.

  11. APPROACHES TO PUBLIC INTEGRITY

    Directory of Open Access Journals (Sweden)

    Simona-Roxana ULMAN

    2015-08-01

    Full Text Available Both concepts, integrity and public integrity, are always asked qualities in the social and economic environment, but they are never well defined. In this context, finding precise definitions and offering an ample explanation of the concepts are desired and useful for both economic theoretical and practical levels and become the aim of the present paper. Without a good understanding of a concept, no one is capable to attain it. In this context, it is impossible to ask for a public sector of integrity if both public actors and the citizens do not know what it really means. Therefore, the public actors first have to understand what integrity really supposes, and, then, to be capable to respect its principles. Taking into consideration the effects of public integrity or, on its opposite, of the divergence from it, especially represented by the phenomenon of corruption, on the economy at the macro, but also, on the micro level, public integrity in itself becomes a real economic problem that is aimed to be extensively analyzed through our interdisciplinary approach.

  12. Fostering Integrity in Research

    Science.gov (United States)

    McNutt, M. K.

    2017-12-01

    The responsible conduct of research requires that all involved in the research enterprise - researchers, sponsors, reviewers, publishers, and communicators - adhere to a set of integrity principles to protect the public's investment. Given the increasing complexity and globalization of the research enterprise, the National Academies recently re-examined and updated its integrity recommendations for researchers in the report Fostering Integrity in Research, with sponsorship from the National Science Foundation. Major departures from the previous recommendations 25-years earlier are the recognition that practices that were previously classified as merely questionable are indeed detrimental to the responsible conduct of research. Furthermore, the report concludes that there has been insufficient effort to respond to the threats that lapses in research integrity pose to the quality of research products and the reputation of researchers as deserving of the public trust. It recommends the creation of an independent, non-profit entity dedicated to promoting research integrity by serving as a resource and clearing house for expertise, advice, materials, and best practices on fostering research integrity and responding to allegations of research misconduct.

  13. Measuring information integration

    Directory of Open Access Journals (Sweden)

    Sporns Olaf

    2003-12-01

    Full Text Available Abstract Background To understand the functioning of distributed networks such as the brain, it is important to characterize their ability to integrate information. The paper considers a measure based on effective information, a quantity capturing all causal interactions that can occur between two parts of a system. Results The capacity to integrate information, or Φ, is given by the minimum amount of effective information that can be exchanged between two complementary parts of a subset. It is shown that this measure can be used to identify the subsets of a system that can integrate information, or complexes. The analysis is applied to idealized neural systems that differ in the organization of their connections. The results indicate that Φ is maximized by having each element develop a different connection pattern with the rest of the complex (functional specialization while ensuring that a large amount of information can be exchanged across any bipartition of the network (functional integration. Conclusion Based on this analysis, the connectional organization of certain neural architectures, such as the thalamocortical system, are well suited to information integration, while that of others, such as the cerebellum, are not, with significant functional consequences. The proposed analysis of information integration should be applicable to other systems and networks.

  14. Imagery Integration Team

    Science.gov (United States)

    Calhoun, Tracy; Melendrez, Dave

    2014-01-01

    The Human Exploration Science Office (KX) provides leadership for NASA's Imagery Integration (Integration 2) Team, an affiliation of experts in the use of engineering-class imagery intended to monitor the performance of launch vehicles and crewed spacecraft in flight. Typical engineering imagery assessments include studying and characterizing the liftoff and ascent debris environments; launch vehicle and propulsion element performance; in-flight activities; and entry, landing, and recovery operations. Integration 2 support has been provided not only for U.S. Government spaceflight (e.g., Space Shuttle, Ares I-X) but also for commercial launch providers, such as Space Exploration Technologies Corporation (SpaceX) and Orbital Sciences Corporation, servicing the International Space Station. The NASA Integration 2 Team is composed of imagery integration specialists from JSC, the Marshall Space Flight Center (MSFC), and the Kennedy Space Center (KSC), who have access to a vast pool of experience and capabilities related to program integration, deployment and management of imagery assets, imagery data management, and photogrammetric analysis. The Integration 2 team is currently providing integration services to commercial demonstration flights, Exploration Flight Test-1 (EFT-1), and the Space Launch System (SLS)-based Exploration Missions (EM)-1 and EM-2. EM-2 will be the first attempt to fly a piloted mission with the Orion spacecraft. The Integration 2 Team provides the customer (both commercial and Government) with access to a wide array of imagery options - ground-based, airborne, seaborne, or vehicle-based - that are available through the Government and commercial vendors. The team guides the customer in assembling the appropriate complement of imagery acquisition assets at the customer's facilities, minimizing costs associated with market research and the risk of purchasing inadequate assets. The NASA Integration 2 capability simplifies the process of securing one

  15. Integrative medicine for cancer treatment

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000932.htm Integrative medicine for cancer treatment To use the sharing features ... This is why many people turn to integrative medicine. Integrative medicine (IM) refers to any type of ...

  16. Integrating the Integrators - A Roadmap to Success

    International Nuclear Information System (INIS)

    Olson, Craig Stott; Conner, Craig C

    1999-01-01

    The U.S. Department of Energy Environmental Management's (DOE-EM) investments in science and technology, as well as science and technology investments associated with other parts of the DOE are aimed at meeting the Departments cleanup goals. These investments, primarily focused on EM's cleanup mission, comprise the Environmental Quality Research and Development (R and D) portfolios. Synchronizing EM's Cleanup Project Managers (operations facility and process owners throughout the DOE complex) operational needs with EM R and D including the extensive work of the six Focus Areas (major thrust areas within DOE-EM) has been a continuing challenge. This recent initiative to better integrate the R and D program is in response to evolving needs within the Department to apply proven system engineering methods to clarify requirements and define EM's process to effectively orchestrate their R and D Program. To optimize this partnership, DOE-EM's Integration Program is successfully unifying the operational needs with the R and D as described in this paper

  17. Necessity of Integral Formalism

    International Nuclear Information System (INIS)

    Tao Yong

    2011-01-01

    To describe the physical reality, there are two ways of constructing the dynamical equation of field, differential formalism and integral formalism. The importance of this fact is firstly emphasized by Yang in case of gauge field [Phys. Rev. Lett. 33 (1974) 445], where the fact has given rise to a deeper understanding for Aharonov-Bohm phase and magnetic monopole [Phys. Rev. D 12 (1975) 3845]. In this paper we shall point out that such a fact also holds in general wave function of matter, it may give rise to a deeper understanding for Berry phase. Most importantly, we shall prove a point that, for general wave function of matter, in the adiabatic limit, there is an intrinsic difference between its integral formalism and differential formalism. It is neglect of this difference that leads to an inconsistency of quantum adiabatic theorem pointed out by Marzlin and Sanders [Phys. Rev. Lett. 93 (2004) 160408]. It has been widely accepted that there is no physical difference of using differential operator or integral operator to construct the dynamical equation of field. Nevertheless, our study shows that the Schrödinger differential equation (i.e., differential formalism for wave function) shall lead to vanishing Berry phase and that the Schrödinger integral equation (i.e., integral formalism for wave function), in the adiabatic limit, can satisfactorily give the Berry phase. Therefore, we reach a conclusion: There are two ways of describing physical reality, differential formalism and integral formalism; but the integral formalism is a unique way of complete description. (general)

  18. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

    International Nuclear Information System (INIS)

    Roy, Lopamudra Das; Ghosh, Sriparna; Pathangey, Latha B; Tinder, Teresa L; Gruber, Helen E; Mukherjee, Pinku

    2011-01-01

    Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth of various malignancies. A common inflammatory condition in humans is autoimmune arthritis (AA). Although AA and cancer are different diseases, many of the underlying processes that contribute to the disorders of the joints and connective tissue that characterize AA also affect cancer progression and metastasis. Systemically, AA can lead to cellular infiltration and inflammation of the lungs. Several studies have reported statistically significant risk ratios between AA and breast cancer. Despite this knowledge being available, there has been minimal research linking breast cancer, arthritis, and metastasis associated with breast cancer. Notably both diseases are extremely prevalent in older post-menopausal women. To establish the novel link between arthritis induced inflammation and secondary metastasis associated with breast cancer, PyV MT mice that spontaneously develop mammary gland carcinoma were injected with Type II collagen (CII) to induce arthritis at 9 and 18 weeks of age for pre-metastatic and metastatic condition. The sites of secondary metastasis and the associated inflammatory microenvironment were evaluated. A significant increase in breast cancer-associated secondary metastasis to the lungs and bones was observed in the arthritic versus the non-arthritic PyV MT mice along with an increase in primary tumor burden. We report significant increases in the levels of interstitial cellular infiltrates and pro-inflammatory cytokines such as interleukin-17 (IL-17), interleukin-6 (IL-6), Pro- Matrix metallopeptidase 9 (Pro-MMP9), insulin like growth factor-II (GF-II) and macrophage colony stimulating factor (M-CSF) in the arthritic lung and bone milieu as well as in the circulation. These pro-inflammatory cytokines along with the inflammatory microenvironment may be the underlying factors facilitating tumor progression and metastasis in arthritic PyV MT mice. This was further substantiated by treatment with celecoxib, an anti-inflammatory drug + αIL-17 antibody that significantly reduced the secondary metastasis to lung and bone. The data generated not only reveal the underlying mechanism of high susceptibility to bone and lung metastasis in an arthritic condition but our combination therapies may lead to treatment modalities that will be capable of reducing tumor burden, and preventing relapse and metastasis in arthritic patients with breast cancer

  19. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

    Directory of Open Access Journals (Sweden)

    Gruber Helen E

    2011-08-01

    Full Text Available Abstract Background Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth of various malignancies. A common inflammatory condition in humans is autoimmune arthritis (AA. Although AA and cancer are different diseases, many of the underlying processes that contribute to the disorders of the joints and connective tissue that characterize AA also affect cancer progression and metastasis. Systemically, AA can lead to cellular infiltration and inflammation of the lungs. Several studies have reported statistically significant risk ratios between AA and breast cancer. Despite this knowledge being available, there has been minimal research linking breast cancer, arthritis, and metastasis associated with breast cancer. Notably both diseases are extremely prevalent in older post-menopausal women. Methods To establish the novel link between arthritis induced inflammation and secondary metastasis associated with breast cancer, PyV MT mice that spontaneously develop mammary gland carcinoma were injected with Type II collagen (CII to induce arthritis at 9 and 18 weeks of age for pre-metastatic and metastatic condition. The sites of secondary metastasis and the associated inflammatory microenvironment were evaluated. Results A significant increase in breast cancer-associated secondary metastasis to the lungs and bones was observed in the arthritic versus the non-arthritic PyV MT mice along with an increase in primary tumor burden. We report significant increases in the levels of interstitial cellular infiltrates and pro-inflammatory cytokines such as interleukin-17 (IL-17, interleukin-6 (IL-6, Pro- Matrix metallopeptidase 9 (Pro-MMP9, insulin like growth factor-II (GF-II and macrophage colony stimulating factor (M-CSF in the arthritic lung and bone milieu as well as in the circulation. These pro-inflammatory cytokines along with the inflammatory microenvironment may be the underlying factors facilitating tumor progression and metastasis in arthritic PyV MT mice. This was further substantiated by treatment with celecoxib, an anti-inflammatory drug + αIL-17 antibody that significantly reduced the secondary metastasis to lung and bone. Conclusions The data generated not only reveal the underlying mechanism of high susceptibility to bone and lung metastasis in an arthritic condition but our combination therapies may lead to treatment modalities that will be capable of reducing tumor burden, and preventing relapse and metastasis in arthritic patients with breast cancer.

  20. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer.

    Science.gov (United States)

    Roy, Lopamudra Das; Ghosh, Sriparna; Pathangey, Latha B; Tinder, Teresa L; Gruber, Helen E; Mukherjee, Pinku

    2011-08-22

    Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth of various malignancies. A common inflammatory condition in humans is autoimmune arthritis (AA). Although AA and cancer are different diseases, many of the underlying processes that contribute to the disorders of the joints and connective tissue that characterize AA also affect cancer progression and metastasis. Systemically, AA can lead to cellular infiltration and inflammation of the lungs. Several studies have reported statistically significant risk ratios between AA and breast cancer. Despite this knowledge being available, there has been minimal research linking breast cancer, arthritis, and metastasis associated with breast cancer. Notably both diseases are extremely prevalent in older post-menopausal women. To establish the novel link between arthritis induced inflammation and secondary metastasis associated with breast cancer, PyV MT mice that spontaneously develop mammary gland carcinoma were injected with Type II collagen (CII) to induce arthritis at 9 and 18 weeks of age for pre-metastatic and metastatic condition. The sites of secondary metastasis and the associated inflammatory microenvironment were evaluated. A significant increase in breast cancer-associated secondary metastasis to the lungs and bones was observed in the arthritic versus the non-arthritic PyV MT mice along with an increase in primary tumor burden. We report significant increases in the levels of interstitial cellular infiltrates and pro-inflammatory cytokines such as interleukin-17 (IL-17), interleukin-6 (IL-6), Pro- Matrix metallopeptidase 9 (Pro-MMP9), insulin like growth factor-II (GF-II) and macrophage colony stimulating factor (M-CSF) in the arthritic lung and bone milieu as well as in the circulation. These pro-inflammatory cytokines along with the inflammatory microenvironment may be the underlying factors facilitating tumor progression and metastasis in arthritic PyV MT mice. This was further substantiated by treatment with celecoxib, an anti-inflammatory drug + αIL-17 antibody that significantly reduced the secondary metastasis to lung and bone. The data generated not only reveal the underlying mechanism of high susceptibility to bone and lung metastasis in an arthritic condition but our combination therapies may lead to treatment modalities that will be capable of reducing tumor burden, and preventing relapse and metastasis in arthritic patients with breast cancer.

  1. Mammary Specific Expression of Cre Recombinase Under the Control of an Endogenous MMTV LTR: A Conditional Knock-Out System

    National Research Council Canada - National Science Library

    Czarneski, Jennifer

    2000-01-01

    .... Mice that carried the Mtv-17 Cre fusion vector would then be mated to mice that had the p53 locus flanked by loxP sites, resulting in the tissue-specific loss of p53 in the mammary gland only. The prediction is that these animals would only develop mammary and not other tumors. We believed that the cre-transgenic mice would also prove useful for other investigators in the mammary gland development and tumorigenesis field.

  2. A Comprehensive Theory of Integration.

    Science.gov (United States)

    Singer, Sara J; Kerrissey, Michaela; Friedberg, Mark; Phillips, Russell

    2018-03-01

    Efforts to transform health care delivery to improve care have increasingly focused on care integration. However, variation in how integration is defined has complicated efforts to design, synthesize, and compare studies of integration in health care. Evaluations of integration initiatives would be enhanced by describing them according to clear definitions of integration and specifying which empirical relationships they seek to test-whether among types of integration or between integration and outcomes of care. Drawing on previous work, we present a comprehensive theoretical model of relationships between types of integration and propose how to measure them.

  3. Integrated Budget Office Toolbox

    Science.gov (United States)

    Rushing, Douglas A.; Blakeley, Chris; Chapman, Gerry; Robertson, Bill; Horton, Allison; Besser, Thomas; McCarthy, Debbie

    2010-01-01

    The Integrated Budget Office Toolbox (IBOT) combines budgeting, resource allocation, organizational funding, and reporting features in an automated, integrated tool that provides data from a single source for Johnson Space Center (JSC) personnel. Using a common interface, concurrent users can utilize the data without compromising its integrity. IBOT tracks planning changes and updates throughout the year using both phasing and POP-related (program-operating-plan-related) budget information for the current year, and up to six years out. Separating lump-sum funds received from HQ (Headquarters) into separate labor, travel, procurement, Center G&A (general & administrative), and servicepool categories, IBOT creates a script that significantly reduces manual input time. IBOT also manages the movement of travel and procurement funds down to the organizational level and, using its integrated funds management feature, helps better track funding at lower levels. Third-party software is used to create integrated reports in IBOT that can be generated for plans, actuals, funds received, and other combinations of data that are currently maintained in the centralized format. Based on Microsoft SQL, IBOT incorporates generic budget processes, is transportable, and is economical to deploy and support.

  4. Reconfigurable Integrated Optoelectronics

    Directory of Open Access Journals (Sweden)

    Richard Soref

    2011-01-01

    Full Text Available Integrated optics today is based upon chips of Si and InP. The future of this chip industry is probably contained in the thrust towards optoelectronic integrated circuits (OEICs and photonic integrated circuits (PICs manufactured in a high-volume foundry. We believe that reconfigurable OEICs and PICs, known as ROEICs and RPICs, constitute the ultimate embodiment of integrated photonics. This paper shows that any ROEIC-on-a-chip can be decomposed into photonic modules, some of them fixed and some of them changeable in function. Reconfiguration is provided by electrical control signals to the electro-optical building blocks. We illustrate these modules in detail and discuss 3D ROEIC chips for the highest-performance signal processing. We present examples of our module theory for RPIC optical lattice filters already constructed, and we propose new ROEICs for directed optical logic, large-scale matrix switching, and 2D beamsteering of a phased-array microwave antenna. In general, large-scale-integrated ROEICs will enable significant applications in computing, quantum computing, communications, learning, imaging, telepresence, sensing, RF/microwave photonics, information storage, cryptography, and data mining.

  5. Fractional Integral Inequalities via Hadamard’s Fractional Integral

    OpenAIRE

    Sudsutad, Weerawat; Ntouyas, Sotiris K.; Tariboon, Jessada

    2014-01-01

    We establish new fractional integral inequalities, via Hadamard’s fractional integral. Several new integral inequalities are obtained, including a Grüss type Hadamard fractional integral inequality, by using Young and weighted AM-GM inequalities. Many special cases are also discussed.

  6. Fractional Integral Inequalities via Hadamard’s Fractional Integral

    Directory of Open Access Journals (Sweden)

    Weerawat Sudsutad

    2014-01-01

    Full Text Available We establish new fractional integral inequalities, via Hadamard’s fractional integral. Several new integral inequalities are obtained, including a Grüss type Hadamard fractional integral inequality, by using Young and weighted AM-GM inequalities. Many special cases are also discussed.

  7. Counting master integrals: integration by parts vs. differential reduction

    OpenAIRE

    Kalmykov, Mikhail Yu.; Kniehl, Bernd A.

    2011-01-01

    The techniques of integration by parts and differential reduction differ in the counting of master integrals. This is illustrated using as an example the two-loop sunset diagram with on-shell kinematics. A new algebraic relation between the master integrals of the two-loop sunset diagram that does not follow from the integration-by-parts technique is found.

  8. Integrity and the Value of an Integrated Self

    NARCIS (Netherlands)

    Archer, Alfred

    What is integrity and why is it valuable? One account of the nature of integrity, proposed by John Cottingham (2010) amongst others, is The Integrated Self View. On this account integrity is a formal relation of coherence between various aspects of a person. One problem that has been raised against

  9. Counting master integrals: Integration by parts vs. differential reduction

    International Nuclear Information System (INIS)

    Kalmykov, Mikhail Yu.; Kniehl, Bernd A.

    2011-01-01

    The techniques of integration by parts and differential reduction differ in the counting of master integrals. This is illustrated using as an example the two-loop sunset diagram with on-shell kinematics. A new algebraic relation between the master integrals of the two-loop sunset diagram that does not follow from the standard integration-by-parts technique is found.

  10. Counting master integrals. Integration by parts vs. differential reduction

    International Nuclear Information System (INIS)

    Kalmykov, Mikhail Yu; Kniehl, Bernd A.

    2011-05-01

    The techniques of integration by parts and differential reduction differ in the counting of master integrals. This is illustrated using as an example the two- loop sunset diagram with on-shell kinematics. A new algebraic relation between the master integrals of the two-loop sunset diagram that does not follow from the integration-by-parts technique is found. (orig.)

  11. INTEGRAL core programme

    Science.gov (United States)

    Gehrels, N.; Schoenfelder, V.; Ubertini, P.; Winkler, C.

    1997-01-01

    The International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission is described with emphasis on the INTEGRAL core program. The progress made in the planning activities for the core program is reported on. The INTEGRAL mission has a nominal lifetime of two years with a five year extension option. The observing time will be divided between the core program (between 30 and 35 percent during the first two years) and general observations. The core program consists of three main elements: the deep survey of the Galactic plane in the central radian of the Galaxy; frequent scans of the Galactic plane in the search for transient sources, and pointed observations of several selected sources. The allocation of the observation time is detailed and the sensitivities of the observations are outlined.

  12. Signal integrity characterization techniques

    CERN Document Server

    Bogatin, Eric

    2009-01-01

    "Signal Integrity Characterization Techniques" addresses the gap between traditional digital and microwave curricula all while focusing on a practical and intuitive understanding of signal integrity effects within the data transmission channel. High-speed interconnects such as connectors, PCBs, cables, IC packages, and backplanes are critical elements of differential channels that must be designed using today's most powerful analysis and characterization tools.Both measurements and simulation must be done on the device under test, and both activities must yield data that correlates with each other. Most of this book focuses on real-world applications of signal integrity measurements - from backplane for design challenges to error correction techniques to jitter measurement technologies. The authors' approach wisely addresses some of these new high-speed technologies, and it also provides valuable insight into its future direction and will teach the reader valuable lessons on the industry.

  13. Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    2016-01-01

    renovation to be overcome. The homeowners were better integrated and their preferences and immaterial values were better taken into account. To keep the decision-making process economically viable and timely, the process as known today still needs to be improved, and new tools need to be developed...... structured and holistic method of decision making toward nearly zero-energy building renovation. The methodology is evolutive, implementable on a large scale, and allows an optimal integration of nonexpert decision makers. In practice, such a scheme allowed most behavioral barriers to sustainable home....... This paper presents a new scheme: the integrated renovation process. One successful case study is introduced, and recommendations for future developments needed in the field are provided....

  14. Integrated magnetic transformer assembly

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to an integrated magnetics transformer assembly comprising a first magnetically permeable core forming a first substantially closed magnetic flux path and a second magnetically permeable core forming a second substantially closed magnetic flux path. A first input...... inductor winding is wound around a first predetermined segment of the first magnetically permeable core and a second input inductor winding is wound around a first predetermined segment of the second magnetically permeable core. The integrated magnetics transformer assembly further comprises a first output......-winding of the first output inductor winding and the first half-winding of the second output inductor winding are configured to produce aligned, i.e. in the same direction, magnetic fluxes through the first substantially closed magnetic flux path. The integrated magnetics transformer assembly is well- suited for use...

  15. Integration eller Illusion

    DEFF Research Database (Denmark)

    Rezaei, Shahamak; Goli, Marco

    2012-01-01

    Integration or illusion – a deviance perspective Denmark experienced one of its most successful periods of economic growth in 2004–2008 with a tremendous reduction of unemployment, which in June 2008 was around. 1.5 percent, far below the expected level of structural unemployment. In the wake...... of migrants’ skills. 2. Whether there were patterns of over-education as expression of institutional and societal discrimination. The focus of the present study is, however, quite different: We examine the pattern of deviance in relation to labour market participation (not integration), and instead...... of searching for explanations for the lack of integration, we attempt to identify and explain the deviance pattern as a product of institutionally inherent possibilities and barriers on the one hand and articulating immigrants as rational actors (not victims) on the other. We argue that deviance is not only...

  16. Measuring integrated care

    DEFF Research Database (Denmark)

    Strandberg-Larsen, Martin

    2011-01-01

    and performance of the Danish healthcare system and the managed care organization Kaiser Permanente, California, US. 5) To compare primary care clinicians' perception of clinical integration in two healthcare systems: Kaiser Permanente, Northern California and the Danish healthcare system. Further to examine....... When comparing Kaiser Permanente, California with the Danish healthcare system, our study suggest that Kaiser Permanente has a population with more documented disease and higher operating costs, and performs better than the Danish healthcare system on the observed quality measures. Substantial...... integration in Kaiser Permanente using the Danish healthcare system as a point of reference our findings support the literature that points to the importance of integrated healthcare delivery as a driver for the performance results of Kaiser Permanente. However caution must be advised before making concrete...

  17. Discrete systems and integrability

    CERN Document Server

    Hietarinta, J; Nijhoff, F W

    2016-01-01

    This first introductory text to discrete integrable systems introduces key notions of integrability from the vantage point of discrete systems, also making connections with the continuous theory where relevant. While treating the material at an elementary level, the book also highlights many recent developments. Topics include: Darboux and Bäcklund transformations; difference equations and special functions; multidimensional consistency of integrable lattice equations; associated linear problems (Lax pairs); connections with Padé approximants and convergence algorithms; singularities and geometry; Hirota's bilinear formalism for lattices; intriguing properties of discrete Painlevé equations; and the novel theory of Lagrangian multiforms. The book builds the material in an organic way, emphasizing interconnections between the various approaches, while the exposition is mostly done through explicit computations on key examples. Written by respected experts in the field, the numerous exercises and the thoroug...

  18. Semantic Observation Integration

    Directory of Open Access Journals (Sweden)

    Werner Kuhn

    2012-09-01

    Full Text Available Although the integration of sensor-based information into analysis and decision making has been a research topic for many years, semantic interoperability has not yet been reached. The advent of user-generated content for the geospatial domain, Volunteered Geographic Information (VGI, makes it even more difficult to establish semantic integration. This paper proposes a novel approach to integrating conventional sensor information and VGI, which is exploited in the context of detecting forest fires. In contrast to common logic-based semantic descriptions, we present a formal system using algebraic specifications to unambiguously describe the processing steps from natural phenomena to value-added information. A generic ontology of observations is extended and profiled for forest fire detection in order to illustrate how the sensing process, and transformations between heterogeneous sensing systems, can be represented as mathematical functions and grouped into abstract data types. We discuss the required ontological commitments and a possible generalization.

  19. Policy, Sport and Integration

    DEFF Research Database (Denmark)

    Agergaard, Sine; Sørensen, Jan Kahr

    2010-01-01

    in sport, although sports clubs do get economic support and are seen as having the potential to solve crucial social issues. The purpose of this article is to analyse and discuss the ways in which the political assumption that sport can enhance social integration is reflected in the practical governance......Increased public funding, more governmental involvement and an emphasis on the instrumental values of physical activities have in general become characteristic of Western nations’ policies towards sport. Denmark is, however, a little different in that there is still little political intervention...... of integration issues in particular in sports clubs. The article is based on a local field study in which we interviewed 10 talented football players with ethnic minority backgrounds and eight coaches and club leaders from six different football clubs. Distinguishing between integration and assimilation...

  20. Acquisition IT Integration

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Øhrgaard, Christian

    2015-01-01

    The IT integration of acquisitions consists an important challenge for the many acquiring organizations. Complementing existing research, this paper searches for explanation to differences in acquirers’ abilities for acquisition IT integration in the external of the acquirer, by a study of the use...... of temporary agency workers. Following an analytic induction approach, theoretically grounded in the re-source-based view of the firm, we identify the complimentary and supplementary roles consultants can assume in acquisition IT integration. Through case studies of three acquirers, we investigate how...... the acquirers appropriate the use of agency workers as part of its acquisition strategy. For the investigated acquirers, assigning roles to agency workers is contingent on balancing the needs of knowledge induction and knowledge retention, as well as experience richness and in-depth under-standing. Composition...

  1. INTEGRATED CORPORATE STRATEGY MODEL

    Directory of Open Access Journals (Sweden)

    CATALINA SORIANA SITNIKOV

    2014-02-01

    Full Text Available Corporations are at present operating in demanding and highly unsure periods, facing a mixture of increased macroeconomic need, competitive and capital market dangers, and in many cases, the prospect for significant technical and regulative gap. Throughout these demanding and highly unsure times, the corporations must pay particular attention to corporate strategy. In present times, corporate strategy must be perceived and used as a function of various fields, covers, and characters as well as a highly interactive system. For the corporation's strategy to become a competitive advantage is necessary to understand and also to integrate it in a holistic model to ensure sustainable progress of corporation activities under the optimum conditions of profitability. The model proposed in this paper is aimed at integrating the two strategic models, Hoshin Kanri and Integrated Strategy Model, as well as their consolidation with the principles of sound corporate governance set out by the OECD.

  2. Integrating education and incubation

    DEFF Research Database (Denmark)

    Hjortsø, Carsten Nico Portefée; Riis, Nina Louise Fynbo

    on the integration of extracurricular activities with formal credit awarding activities. In a Danish context, such integration has become increasingly important due to recent political reforms aimed at shortening the time it takes students to graduate in order to reduce national higher education expenditures....... On this backdrop, this paper explores the following questions: • How and to what extent do university student incubators collaborate with formal study programmes? • And which factors influence this integration of curricular and extracurricular activities?......During the last decade student business incubation activities have become mainstream activities in Western universities. This is also the case in Danish higher education where all universities have established in-house student incubators. The models applied are different and place varied emphasis...

  3. Integrative oncology: an overview.

    Science.gov (United States)

    Deng, Gary; Cassileth, Barrie

    2014-01-01

    Integrative oncology, the diagnosis-specific field of integrative medicine, addresses symptom control with nonpharmacologic therapies. Known commonly as "complementary therapies" these are evidence-based adjuncts to mainstream care that effectively control physical and emotional symptoms, enhance physical and emotional strength, and provide patients with skills enabling them to help themselves throughout and following mainstream cancer treatment. Integrative or complementary therapies are rational and noninvasive. They have been subjected to study to determine their value, to document the problems they ameliorate, and to define the circumstances under which such therapies are beneficial. Conversely, "alternative" therapies typically are promoted literally as such; as actual antitumor treatments. They lack biologic plausibility and scientific evidence of safety and efficacy. Many are outright fraudulent. Conflating these two very different categories by use of the convenient acronym "CAM," for "complementary and alternative therapies," confuses the issue and does a substantial disservice to patients and medical professionals. Complementary and integrative modalities have demonstrated safety value and benefits. If the same were true for "alternatives," they would not be "alternatives." Rather, they would become part of mainstream cancer care. This manuscript explores the medical and sociocultural context of interest in integrative oncology as well as in "alternative" therapies, reviews commonly-asked patient questions, summarizes research results in both categories, and offers recommendations to help guide patients and family members through what is often a difficult maze. Combining complementary therapies with mainstream oncology care to address patients' physical, psychologic and spiritual needs constitutes the practice of integrative oncology. By recommending nonpharmacologic modalities that reduce symptom burden and improve quality of life, physicians also enable

  4. Auditory Integration Training

    Directory of Open Access Journals (Sweden)

    Zahra Jafari

    2002-07-01

    Full Text Available Auditory integration training (AIT is a hearing enhancement training process for sensory input anomalies found in individuals with autism, attention deficit hyperactive disorder, dyslexia, hyperactivity, learning disability, language impairments, pervasive developmental disorder, central auditory processing disorder, attention deficit disorder, depressin, and hyperacute hearing. AIT, recently introduced in the United States, and has received much notice of late following the release of The Sound of a Moracle, by Annabel Stehli. In her book, Mrs. Stehli describes before and after auditory integration training experiences with her daughter, who was diagnosed at age four as having autism.

  5. Review: Auditory Integration Training

    Directory of Open Access Journals (Sweden)

    Zahra Ja'fari

    2003-01-01

    Full Text Available Auditory integration training (AIT is a hearing enhancement training process for sensory input anomalies found in individuals with autism, attention deficit hyperactive disorder, dyslexia, hyperactivity, learning disability, language impairments, pervasive developmental disorder, central auditory processing disorder, attention deficit disorder, depression, and hyper acute hearing. AIT, recently introduced in the United States, and has received much notice of late following the release of the sound of a miracle, by Annabel Stehli. In her book, Mrs. Stehli describes before and after auditory integration training experiences with her daughter, who was diagnosed at age four as having autism.

  6. Smart Grid Integration Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Troxell, Wade [Colorado State Univ., Fort Collins, CO (United States)

    2011-12-22

    The initial federal funding for the Colorado State University Smart Grid Integration Laboratory is through a Congressionally Directed Project (CDP), DE-OE0000070 Smart Grid Integration Laboratory. The original program requested in three one-year increments for staff acquisition, curriculum development, and instrumentation all which will benefit the Laboratory. This report focuses on the initial phase of staff acquisition which was directed and administered by DOE NETL/ West Virginia under Project Officer Tom George. Using this CDP funding, we have developed the leadership and intellectual capacity for the SGIC. This was accomplished by investing (hiring) a core team of Smart Grid Systems engineering faculty focused on education, research, and innovation of a secure and smart grid infrastructure. The Smart Grid Integration Laboratory will be housed with the separately funded Integrid Laboratory as part of CSU's overall Smart Grid Integration Center (SGIC). The period of performance of this grant was 10/1/2009 to 9/30/2011 which included one no cost extension due to time delays in faculty hiring. The Smart Grid Integration Laboratory's focus is to build foundations to help graduate and undergraduates acquire systems engineering knowledge; conduct innovative research; and team externally with grid smart organizations. Using the results of the separately funded Smart Grid Workforce Education Workshop (May 2009) sponsored by the City of Fort Collins, Northern Colorado Clean Energy Cluster, Colorado State University Continuing Education, Spirae, and Siemens has been used to guide the hiring of faculty, program curriculum and education plan. This project develops faculty leaders with the intellectual capacity to inspire its students to become leaders that substantially contribute to the development and maintenance of Smart Grid infrastructure through topics such as: (1) Distributed energy systems modeling and control; (2) Energy and power conversion; (3

  7. Integrality in codimension one

    DEFF Research Database (Denmark)

    Thorup, Anders

    2014-01-01

    by Kleiman and the present author. In addition, the paper contained the following theorem: Let R ⊆ S be an extension of commutative rings, where R is noetherian, universally catenary, and locally equidimensional. Then the extension R ⊆ S is integral if minimal primes of S contract to minimal primes of R and......, for every prime p of height at most 1 in R, the extension Rp ⊆ Sp is integral. Themain purpose of the present note is to give an alternative proof of the theorem, based on standard techniques of projective geometry. In addition, the results on the exceptional fiber, considered previously by Kleiman...

  8. Google analytics integrations

    CERN Document Server

    Waisberg, Daniel

    2015-01-01

    A roadmap for turning Google Analytics into a centralized marketing analysis platform With Google Analytics Integrations, expert author Daniel Waisberg shows you how to gain a more meaningful, complete view of customers that can drive growth opportunities. This in-depth guide shows not only how to use Google Analytics, but also how to turn this powerful data collection and analysis tool into a central marketing analysis platform for your company. Taking a hands-on approach, this resource explores the integration and analysis of a host of common data sources, including Google AdWords, AdSens

  9. Acoustic integrated extinction

    OpenAIRE

    Norris, Andrew N.

    2015-01-01

    The integrated extinction (IE) is defined as the integral of the scattering cross section as a function of wavelength. Sohl et al. (2007 J. Acoust. Soc. Am. 122, 3206–3210. (doi:10.1121/1.2801546)) derived an IE expression for acoustic scattering that is causal, i.e. the scattered wavefront in the forward direction arrives later than the incident plane wave in the background medium. The IE formula was based on electromagnetic results, for which scattering is causal by default. Here, we der...

  10. Integrity at CERN

    CERN Document Server

    Department, HR

    2015-01-01

    In the fulfillment of its mission, CERN relies upon the trust and material support of its Member States and partners, and is committed to exercising exemplary stewardship of the resources with which it is entrusted. Accordingly, CERN expects the highest level of integrity from all its contributors (whether members of the personnel, consultants, contractors working on site, or persons engaged in any other capacity at or on behalf of CERN). Integrity is a core value of CERN, defined in the Code of Conduct as “behaving ethically, with intellectual honesty and being accountable for one’s own actions”.

  11. Mapping the Integrity Landscape

    DEFF Research Database (Denmark)

    Douglas-Jones, Rachel; Wright, Susan

    2017-01-01

    This working paper addresses the question, ‘How has the idea of research integrity arisen?’ and assembles an international overview of key moments, documents and organisations that have shaped the field as it operates today. This policy field is rich in actors, declarations, concordats, statements...... integrity into different policy environments. The working paper is organised by geographical regions – global, USA, Europe, and then within Europe, the UK, Iberian and Nordic countries. Each section details the main organisations involved and summarises the documents they have produced, focusing on the ways...

  12. Integrated heterodyne terahertz transceiver

    Science.gov (United States)

    Lee, Mark [Albuquerque, NM; Wanke, Michael C [Albuquerque, NM

    2009-06-23

    A heterodyne terahertz transceiver comprises a quantum cascade laser that is integrated on-chip with a Schottky diode mixer. An antenna connected to the Schottky diode receives a terahertz signal. The quantum cascade laser couples terahertz local oscillator power to the Schottky diode to mix with the received terahertz signal to provide an intermediate frequency output signal. The fully integrated transceiver optimizes power efficiency, sensitivity, compactness, and reliability. The transceiver can be used in compact, fieldable systems covering a wide variety of deployable applications not possible with existing technology.

  13. Pentaho data integration cookbook

    CERN Document Server

    Meadows, Alex

    2013-01-01

    Pentaho Data Integration Cookbook Second Edition is written in a cookbook format, presenting examples in the style of recipes.This allows you to go directly to your topic of interest, or follow topics throughout a chapter to gain a thorough in-depth knowledge.Pentaho Data Integration Cookbook Second Edition is designed for developers who are familiar with the basics of Kettle but who wish to move up to the next level.It is also aimed at advanced users that want to learn how to use the new features of PDI as well as and best practices for working with Kettle.

  14. Integrating education and incubation

    DEFF Research Database (Denmark)

    Hjortsø, Carsten Nico Portefée; Riis, Nina Louise Fynbo

    During the last decade student business incubation activities have become mainstream activities in Western universities. This is also the case in Danish higher education where all universities have established in-house student incubators. The models applied are different and place varied emphasis...... on the integration of extracurricular activities with formal credit awarding activities. In a Danish context, such integration has become increasingly important due to recent political reforms aimed at shortening the time it takes students to graduate in order to reduce national higher education expenditures...

  15. Finnish care integrated?

    Directory of Open Access Journals (Sweden)

    Jouni Niskanen

    2002-06-01

    Full Text Available The public Finnish social and health care system has been challenged by the economic crisis, administrative reforms and increased demands. Better integration as a solution includes many examples, which have been taken to use. The most important are the rewritten national and municipals strategies and quality recommendations, where the different sectors and the levels of care are seen as one entity. Many reorganisations have taken place, both nationally and locally, and welfare clusters have been established. The best examples of integrated care are the forms of teamwork, care management, emphasis on non-institutional care and the information technology.

  16. Environmental integrity, racism, health.

    Science.gov (United States)

    Westra, L

    1996-05-17

    Environmental degradation seriously affects human health. Thus, a close relationship exists between the protection of ecosystem integrity and wilderness on one hand, and human health on the other. However, there is an overarching, holistic perspective in laws and regulations--as well as morality--to to maintain a healthy relationship between the two. Problem areas focused on in this paper are: (a) climate change and global warming; (b) food production; and (c) global equity. This paper argues for the principle of integrity, which provides an holistic perspective, suggested as a better approach than that of current regulations to mitigate against associated threats to human health.

  17. Control system integration

    CERN Document Server

    Shea, T J

    2008-01-01

    This lecture begins with a definition of an accelerator control system, and then reviews the control system architectures that have been deployed at the larger accelerator facilities. This discussion naturally leads to identification of the major subsystems and their interfaces. We shall explore general strategies for integrating intelligent devices and signal processing subsystems based on gate arrays and programmable DSPs. The following topics will also be covered: physical packaging; timing and synchronization; local and global communication technologies; interfacing to machine protection systems; remote debugging; configuration management and source code control; and integration of commercial software tools. Several practical realizations will be presented.

  18. Apache Solr PHP integration

    CERN Document Server

    Kumar, Jayant

    2013-01-01

    This book is full of step-by-step example-oriented tutorials which will show readers how to integrate Solr in PHP applications using the available libraries, and boost the inherent search facilities that Solr offers.If you are a developer who knows PHP and is interested in integrating search into your applications, this is the book for you. No advanced knowledge of Solr is required. Very basic knowledge of system commands and the command-line interface on both Linux and Windows is required. You should also be familiar with the concept of Web servers.

  19. Negative dimensional integrals. Pt. 1

    International Nuclear Information System (INIS)

    Halliday, I.G.; Ricotta, R.M.

    1987-01-01

    We propose a new method of evaluating integrals based on negative dimensional integration. We compute Feynman graphs by considering analytic extensions. Propagators are raised to negative integer powers and integrated over negative integer dimensions. We are left with the problem of computing polynomial integrals and summing finite series. (orig.)

  20. Rule-based Information Integration

    NARCIS (Netherlands)

    de Keijzer, Ander; van Keulen, Maurice

    2005-01-01

    In this report, we show the process of information integration. We specifically discuss the language used for integration. We show that integration consists of two phases, the schema mapping phase and the data integration phase. We formally define transformation rules, conversion, evolution and

  1. Environmental policy integration

    NARCIS (Netherlands)

    Grift-Simeonova, van der Vanya; Valk, van der Arnold

    2016-01-01

    As urban areas continue to expand, the need to consider nature conservation objectives in planning is growing. Policy makers across Europe recognize that effective nature conservation requires an integrated approach to land use planning that includes relevant ecological and spatial knowledge.

  2. Integrated Land Management

    DEFF Research Database (Denmark)

    Enemark, Stig

    2004-01-01

    This paper aims to build a general understanding and conceptual approach to integrated land management. The conceptual understanding may take the form of a hierarchy of levels. The foundation stone is an overall national land policy. Appropriate cadastral systems support land policies by providin...

  3. Educational Technology: Integration?

    Science.gov (United States)

    Christensen, Dean L.; Tennyson, Robert D.

    This paper presents a perspective of the current state of technology-assisted instruction integrating computer language, artificial intelligence (AI), and a review of cognitive science applied to instruction. The following topics are briefly discussed: (1) the language of instructional technology, i.e., programming languages, including authoring…

  4. Integration in sight?

    NARCIS (Netherlands)

    Willem Huijnk; Iris Andriessen

    2016-01-01

    Orininal title: Integratie in zicht? Migration and integration top the list of social problems which worry people in the Netherlands the most. Radicalisation, the controversy surrounding the folklore figure Zwarte Piet (‘Black Pete’), the refugee crisis and ethnic profiling are just a

  5. Integrated Safeguards in Ukraine

    International Nuclear Information System (INIS)

    Fazly, O.

    2015-01-01

    Integrated safeguards are being implemented in Ukraine since 2012. Integrated safeguards are the optimum combination of all safeguards measures available to the IAEA under Comprehensive Safeguards Agreement and Additional Protocol to achieve maximum effectiveness and efficiency in meeting the safeguards obligation within available resources. The implementation of integrated safeguards has provided both advantages and disadvantages for Ukraine. It will be discussed. The concept of unannounced inspections under the integrated safeguards compared to traditional safeguards is the one of the major issues. The use of unannounced inspections, i.e., inspections for which no advance notification regarding inspection activities or location in accordance with paragraph 84 of Safeguards agreement. Ukrainian state inspectors organize and take part in each IAEA inspection and complementary access. Analysis of the quantity and type of IAEA inspections and complementary accesses will be made. Also, a short presentation of software for support of IAEA inspections will be made. After due consideration of the LOF's information, the results of last inspections carried out and non-nuclear use of the depleted uranium, State Nuclear Regulatory Inspectorate of Ukraine decided to send to IAEA the exemption requests for nuclear material of LOF's according to Article 36(b) of the Safeguards Agreement. In conclusion, the development and building of a strong and effective SSAC is never completed. Our plans of SSAC development (legislation, training activities) will be presented. (author)

  6. Body Integrity Identity Disorder

    NARCIS (Netherlands)

    Blom, Rianne M.; Hennekam, Raoul C.; Denys, Damiaan

    2012-01-01

    Introduction: Body Integrity Identity Disorder (BIID) is a rare, infrequently studied and highly secretive condition in which there is a mismatch between the mental body image and the physical body. Subjects suffering from BIID have an intense desire to amputate a major limb or severe the spinal

  7. Laboratories: Integrating Services

    Centers for Disease Control (CDC) Podcasts

    2011-04-04

    This podcast highlights the importance of integrating laboratory services to maximize service delivery to patients.  Created: 4/4/2011 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 4/7/2011.

  8. An Integrated Learning Experience.

    Science.gov (United States)

    Armstrong, Jackie; Landi, Kristina

    1990-01-01

    Describes a fifth grade social studies unit on ancient civilizations that includes a comprehensive history of ancient Egypt, Rome, and Greece and integrates studio art, art history, library science, social studies, and computer literacy programs. Students utilize the library to do research and develop an oral presentation while also working on…

  9. Rebellion to Integration:

    NARCIS (Netherlands)

    Kahin, Audrey

    2000-01-01

    This study deals with the political history of the Indonesian province of West Sumatra and the Minangkabau people from the late colonial period up to the present, focussing on the course and degree of their integration into the contemporary Indonesian state. The book provides a local perspective on

  10. Integrated waste management

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, B. [Global Engineering Services Ltd., Toronto, ON (Canada)

    2000-07-01

    The separation of municipal garbage into pulp, compost (animal feed, or ethanol), metals, tin and glass was discussed. The separation process and complete diversion from sanitary landfills is currently possible. This paper briefly described some of the documented processes and the equipment which is currently available. Global Engineering Services Ltd. has combined two existing processes to produce a single integrated waste disposal and recovery system. In this system, a normal composting plant has been combined with a hydro-pulping unit and other methods to process separated materials. This paper focused on the theme of integration and on the principles of conservation of natural resources. It was emphasized that integrated waste processing can be accomplished by implementing various technologies. It was also emphasized that most importantly, principles of conservation must be adopted to reduce energy use and the production of liquid and solid waste. Integrated waste processing methods can then be implemented. The author also suggested the possibility of using existing processes to use recycled materials for the low cost housing projects in Canada and in other developing countries.

  11. The Social Integration Scale.

    Science.gov (United States)

    Ross, Susan M.; Straus, Murray A.

    The Social Integration Scale (SIS) is intended to facilitate empirical research on the applicability of control theory to many types of adult crime, including "street crime," white collar crime, and physical assaults on spouses. There are five subscales: (1) belief (belief in law and social control); (2) commitment (psychological…

  12. Integral Fast Reactor Program

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1993-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

  13. Integration of CERN staff

    CERN Multimedia

    CERN PhotoLab

    1965-01-01

    An example of the integration of CERN staff in the neighbouring communes is provided by the hamlet of Bugnon at St-Genis-Pouilly (Ain), FRance. The CERN installation on the Swiss site are visible on the left in the background. Behind them the Saleve mountain in Haute-Savoie.

  14. Astrophysics: An Integrative Course

    Science.gov (United States)

    Gutsche, Graham D.

    1975-01-01

    Describes a one semester course in introductory stellar astrophysics at the advanced undergraduate level. The course aims to integrate all previously learned physics by applying it to the study of stars. After a brief introductory section on basic astronomical measurements, the main topics covered are stellar atmospheres, stellar structure, and…

  15. Integrable two dimensional supersystems

    International Nuclear Information System (INIS)

    Tripathy, K.C.; Tripathy, L.K.

    1988-08-01

    The integrability of two dimensional time-dependent classical systems is examined in N=2 superspace using Dirac's second class constraints. The invariants involving quadratic powers in velocities for super harmonic oscillator and super Kepler potentials have been derived. (author). 5 refs

  16. Gender and Academic Integrity.

    Science.gov (United States)

    Hendershott, Anne; Drinan, Patrick F.; Cross, Megan

    1999-01-01

    Investigates the academic integrity climate of a mid-sized, comprehensive, private university. Seeks to assess gender differences in motivations surrounding cheating behaviors among 532 undergraduate students. Findings indicate that while both males and females are reluctant to report instances of academic dishonesty that they witness, there…

  17. European Integration and Globalization

    Directory of Open Access Journals (Sweden)

    Diana Bobica

    2010-06-01

    Full Text Available According to many, the term globalization is able to explain any phenomenon whatsoever, be it positive or negative, that takes place within the global social system. It seems like a sort of magical formula, which is to be found in the speeches of all sorts of people, be they economists, politicians, businessmen or sociologists. However this magical formula of globalization has its limitations, since it encompasses a certain amount of quibbling, beyond which not many can pass. In the context of globalization there appears the question on its role in the process of European integration. Is European integration a part of this global process or, quite on the contrary, does it present certain distinctive features, as it moulds itself differently from the globalization phenomenon? A clear-cut answer seems difficult because of the various aspects involved. Not only the general phenomenon of globalization, but also the economic integration on European level is based on the liberalization of markets and on the opening of national economies towards the exterior,having as direct consequence the intensification of trade exchanges. If from a global point of view one may talk of a market fundamentalism in that the market principles know no boundary, European integration on the other hand implies not only market economy, but also a guided and monitored action of Member Statesaccording to the needs of the whole entity, also taking into consideration - as far as possible – all aspects and consequences on social level.

  18. Integrated Optical lightguide device

    NARCIS (Netherlands)

    Heideman, Rene; Lambeck, Paul; Veldhuis, G.J.

    2000-01-01

    In an integrated optical lightguide device including a light-transmitting core layer, an inclusion or buffer layer, and an active or cladding layer. The cladding layer is divided into segments. Groups of different segments exhibit different refractive indices, light intensity profiles or different

  19. Integrated Optical lightguide device

    NARCIS (Netherlands)

    Heideman, Rene; Lambeck, Paul; Veldhuis, G.J.

    2005-01-01

    In an integrated optical lightguide device including a light-transmitting core layer, an inclusion or buffer layer, and an active or cladding layer. The cladding layer is divided into segments. Groups of different segments exhibit different refractive indices, light intensity profiles or different

  20. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.; Lineberry, M.J.

    1990-01-01

    Argonne National Laboratory, since 1984, has been developing the Integral Fast Reactor (IFR). This paper will describe the way in which this new reactor concept came about; the technical, public acceptance, and environmental issues that are addressed by the IFR; the technical progress that has been made; and our expectations for this program in the near term. 5 refs., 3 figs

  1. Integral Fast Reactor concept

    Energy Technology Data Exchange (ETDEWEB)

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path.

  2. Integral Fast Reactor concept

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path

  3. Safeguarding genome integrity

    DEFF Research Database (Denmark)

    Sørensen, Claus Storgaard; Syljuåsen, Randi G

    2012-01-01

    Mechanisms that preserve genome integrity are highly important during the normal life cycle of human cells. Loss of genome protective mechanisms can lead to the development of diseases such as cancer. Checkpoint kinases function in the cellular surveillance pathways that help cells to cope with DNA...

  4. Integrable and superintegrable systems

    CERN Document Server

    1990-01-01

    Some of the most active practitioners in the field of integrable systems have been asked to describe what they think of as the problems and results which seem to be most interesting and important now and are likely to influence future directions. The papers in this collection, representing their authors' responses, offer a broad panorama of the subject as it enters the 1990's.

  5. symmetrically deformed integrable systems

    Indian Academy of Sciences (India)

    only motivation provided is that such models are likely to have real spectra. How- ever, in the context of integrable ... not lead to the desired result. However, we may consistently impose some .... Having seen that merely adding terms to complex Hamiltonians leads to rather simple models, we comment on some of the other ...

  6. 3 CFR - Scientific Integrity

    Science.gov (United States)

    2010-01-01

    ... Administration on a wide range of issues, including improvement of public health, protection of the environment... information in policymaking. The selection of scientists and technology professionals for positions in the..., and integrity. By this memorandum, I assign to the Director of the Office of Science and Technology...

  7. Cuadro de mando integral

    OpenAIRE

    Alejandra Falco

    2008-01-01

    Describe el cuadro de mando integral como un instrumento vinculado al sistema de información, útil para encaminar la actuación de las instituciones en la consecución de los propósitos y fines de la empresa.

  8. Operational Amplifer Integrator

    NARCIS (Netherlands)

    van Tuijl, Adrianus Johannes Maria

    2003-01-01

    An integrator circuit comprises an operational amplifier which has a transistor stage (1) with an input terminal (4) and an output terminal (3), a feedback capacitor (2) connected between the input terminal (4) and the output terminal (3), and a resistor (5) connected to the input terminal (4), and

  9. Toughness in Integrative Bargaining.

    Science.gov (United States)

    Tutzauer, Frank

    1993-01-01

    Introduces a new measure of bargaining toughness based on dynamical information that can easily be used in integrative bargaining scenarios. Develops a mathematical measure of bargaining toughness that takes into account not only how much the bargainer has conceded but how fast he or she has done so. (RS)

  10. ALICE-ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva

    2008-01-01

    Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data...

  11. Sensing train integrity

    NARCIS (Netherlands)

    Scholten, Johan; Westenberg, Roel; Schoemaker, Manfred

    2009-01-01

    This paper presents a new approach to check integrity of cargo trains based on a distributed wireless sensor network (WSN). The WSN is autonomous and gathers information about the composition of the train without outside help or intervention. If the WSN infers from its data that an unexpected change

  12. Coercion and integration

    NARCIS (Netherlands)

    Vala Elias Pimentel de Oliveira, G.

    2017-01-01

    Coercion and integration are widely used to reduce transaction costs. The threat of fines is often the most efficient way to make people pay their taxes. M&A consulting firms and the European Union exist because companies and countries perceive value in concentrating some of their functions under

  13. Sesquilinear uniform vector integral

    Indian Academy of Sciences (India)

    examples are exhibited. The necessary prerequisites of functional analysis can be found, e.g., in [4] and Part I of [9]. For general topology, see [10]. The authors intend to use the integral introduced in this paper in a series of further papers, dedicated to various topics, such as measure spaces, optimal transport and fractals.

  14. GEOSS Water Cycle Integrator

    Science.gov (United States)

    Koike, Toshio; Lawford, Richard; Cripe, Douglas

    2013-04-01

    It is critically important to recognize and co-manage the fundamental linkages across the water-dependent domains; land use, including deforestation; ecosystem services; and food-, energy- and health-securities. Sharing coordinated, comprehensive and sustained observations and information for sound decision-making is a first step; however, to take full advantage of these opportunities, we need to develop an effective collaboration mechanism for working together across different disciplines, sectors and agencies, and thereby gain a holistic view of the continuity between environmentally sustainable development, climate change adaptation and enhanced resilience. To promote effective multi-sectoral, interdisciplinary collaboration based on coordinated and integrated efforts, the intergovernmental Group on Earth Observations (GEO) is implementing the Global Earth Observation System of Systems (GEOSS). A component of GEOSS now under development is the "GEOSS Water Cycle Integrator (WCI)", which integrates Earth observations, modeling, data and information, management systems and education systems. GEOSS/WCI sets up "work benches" by which partners can share data, information and applications in an interoperable way, exchange knowledge and experiences, deepen mutual understanding and work together effectively to ultimately respond to issues of both mitigation and adaptation. (A work bench is a virtual geographical or phenomenological space where experts and managers collaborate to use information to address a problem within that space). GEOSS/WCI enhances the coordination of efforts to strengthen individual, institutional and infrastructure capacities, especially for effective interdisciplinary coordination and integration. GEO has established the GEOSS Asian Water Cycle Initiative (AWCI) and GEOSS African Water Cycle Coordination Initiative (AfWCCI). Through regional, inter-disciplinary, multi-sectoral integration and inter-agency coordination in Asia and Africa, GEOSS

  15. Choosing the Right Systems Integration

    Directory of Open Access Journals (Sweden)

    Péči Matúš

    2014-12-01

    Full Text Available The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

  16. Choosing the Right Systems Integration

    Science.gov (United States)

    Péči, Matúš; Važan, Pavel

    2014-12-01

    The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

  17. Performing Task Integration

    DEFF Research Database (Denmark)

    Elkjaer, Bente; Nickelsen, Niels Christian Mossfeldt

    In the paper, we deal with how to organize work for cross-professional knowledge sharing. We do so inspired by relational coordination theory, which is affiliated with positive organizational scholarship. Relational coordination theory is constituted by a combination of relationships marked...... by shared goals and knowledge as well as mutual respect and frequent, timely, accurate and problem-solving ways of communication with the purpose of dealing with the tasks at hand in an integrated way. We introduce and discuss relational coordination theory through a case-study within public healthcare....... Here cross-professional coordination of work was done by scheduled communication twice a day. When we proposed a way for further integration of tasks through an all-inclusive team organization, we were met with resistance. We use the study to discuss whether relational coordination theory is able to do...

  18. "Integrative Social Robotics"

    DEFF Research Database (Denmark)

    Seibt, Johanna

    2016-01-01

    The aim of this paper is to sketch the basic motivations for “Integrative Social Robotics” (ISR), as a new paradigm for how to approach research, design, and development of social robotics applications that are culturally sustainable. I argue that social robotics saddles us with normative......-regulatory and descriptive questions that currently are kept too far apart. Currently HRI research investigates what social robots can do and robo-ethicists deliberate afterwards what robots should do. However, given the rapid pace of the robotics industry, descriptive and regulatory questions must be treated in combination....... On the ISR approach research in social robotics turns on what social robots can and should do--design and development are from the very beginning informed by value-theoretic and cultural research. ISR thus is a form of research organization that integrates robotics with empirical, conceptual, and value...

  19. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas

    performance sustainable renovations. The main purpose of the work has been to develop a holistic methodology so as to inspire and guide building owners and their renovation project teams to reach high levels of social, environmental and economic performances. The research approach integrates multiple......Buildings are one of the largest end users of energy. In the countries of the European Union, the building sector accounts for nearly 40% of the final energy use and represents one of the largest potentials for the reduction of energy use and of greenhouse gas emissions. Furthermore, today...... disciplines including architectural, process, energy and environmental engineering as well as economics, psychology and social sciences. The developed methodology is implementable on a large scale and allows an optimal integration of non-expert decision makers and associated project stakeholders...

  20. Measure, integral and probability

    CERN Document Server

    Capiński, Marek

    2004-01-01

    Measure, Integral and Probability is a gentle introduction that makes measure and integration theory accessible to the average third-year undergraduate student. The ideas are developed at an easy pace in a form that is suitable for self-study, with an emphasis on clear explanations and concrete examples rather than abstract theory. For this second edition, the text has been thoroughly revised and expanded. New features include: · a substantial new chapter, featuring a constructive proof of the Radon-Nikodym theorem, an analysis of the structure of Lebesgue-Stieltjes measures, the Hahn-Jordan decomposition, and a brief introduction to martingales · key aspects of financial modelling, including the Black-Scholes formula, discussed briefly from a measure-theoretical perspective to help the reader understand the underlying mathematical framework. In addition, further exercises and examples are provided to encourage the reader to become directly involved with the material.

  1. Integrative Pediatrics: Looking Forward

    Directory of Open Access Journals (Sweden)

    Hilary McClafferty

    2015-01-01

    Full Text Available Increase in the prevalence of disease and illness has dramatically altered the landscape of pediatrics. As a result, there is a demand for pediatricians with new skills and a sharper focus on preventative health. Patient demand and shifting pediatric illness patterns have accelerated research in the field of pediatric integrative medicine. This emerging field can be defined as healing-oriented medicine that considers the whole child, including all elements of lifestyle and family health. It is informed by evidence and carefully weighs all appropriate treatment options. This Special Issue of Children, containing a collection of articles written by expert clinicians, represents an important educational contribution to the field. The goal of the edition is to raise awareness about integrative topics with robust supporting evidence, and to identify areas where more research is needed.

  2. Integrated turbomachine oxygen plant

    Science.gov (United States)

    Anand, Ashok Kumar; DePuy, Richard Anthony; Muthaiah, Veerappan

    2014-06-17

    An integrated turbomachine oxygen plant includes a turbomachine and an air separation unit. One or more compressor pathways flow compressed air from a compressor through one or more of a combustor and a turbine expander to cool the combustor and/or the turbine expander. An air separation unit is operably connected to the one or more compressor pathways and is configured to separate the compressed air into oxygen and oxygen-depleted air. A method of air separation in an integrated turbomachine oxygen plant includes compressing a flow of air in a compressor of a turbomachine. The compressed flow of air is flowed through one or more of a combustor and a turbine expander of the turbomachine to cool the combustor and/or the turbine expander. The compressed flow of air is directed to an air separation unit and is separated into oxygen and oxygen-depleted air.

  3. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1985-01-01

    During the past two years, scientists from Argonne have developed an advanced breeder reactor with a closed self contained fuel cycle. The Integral Fast Reactor (IFR) is a new reactor concept, adaptable to a variety of designs, that is based on a fuel cycle radically different from the CRBR line of breeder development. The essential features of the IFR are metal fuel, pool layout, and pyro- and electro-reprocessing in a facility integral with the reactor plant. The IFR shows promise to provide an inexhaustible, safe, economic, environmentally acceptable, and diversion resistant source of nuclear power. It shows potential for major improvement in all of the areas that have led to concern about nuclear power

  4. Pedagogical integration and regionalisation

    Directory of Open Access Journals (Sweden)

    Jan Gustafsson

    2010-12-01

    Full Text Available Abstract: The purpose of this research is concerned with the intentions of pedagogical integration and the notion of an expanded concept of teaching as described in the National School Curriculum of Sweden. In the analysis a theoretical synthesis comprising critical discourse analysis and sociological theories of institutional identities and processes is used through a policy ethnography approach. Purpose has been focus on the relationship between the formal, written curriculum and specific, local, classroom practices. The analysis shows that the Pedagogical dimensions of integration were transformed toward economic interests and control at the local political level. Education work is distinctly regionalising into two so-called safety zones, and a hybrid zone. Four different pedagogical identities are also identified in the analysis. The analysis thus suggests that the creation of safety zones restricts education work to pre-existing patterns. Only the hybrid zone is presently carrying a potential to significantly renew education and encourage and social change.

  5. Crisis and Regional Integration

    DEFF Research Database (Denmark)

    Dosenrode, Søren

    ‘Crisis’ has been a word frequently heard of over the last couple of years, both in a global meaning (e.g. the environmental crisis, the financial crisis) and also in a more regional or national meaning, many times related to Africa (Horn of Africa, Ivory Coast, DR Congo, Zimbabwe, Ivory Coast......, Tunisia, Egypt …. ), where the crisis referred to could be humanitarian, environmental, economic, political … Europe, too, has also according to mass media, been a victim of a crisis, the financial one. Could ‘crisis’ be a beginning of enhanced regional integration? This paper will try to look...... at the processes of regional integration in relation to ‘crisis’ in Africa and Europe. First, this paper will look at the concept of ‘crisis’, before it moves on to discuss ‘regional integration’ and the correlation between the two, emphasizing the approaches of neo-functionalism and federal theory...

  6. Religion, migration og integration

    DEFF Research Database (Denmark)

    Borup, Jørn

    2010-01-01

    Sammenhængen mellem religion og integration har de sidste år været genstand for debat. Artiklen kommer ind på begreber og sammenhænge relateret til området (migration, diaspora, assimilation, etnicitet, kultur) og ser på religionens mulige rolle som negativ eller positiv ressource i integrationss......Sammenhængen mellem religion og integration har de sidste år været genstand for debat. Artiklen kommer ind på begreber og sammenhænge relateret til området (migration, diaspora, assimilation, etnicitet, kultur) og ser på religionens mulige rolle som negativ eller positiv ressource i...

  7. Integrating over Higgs branches

    International Nuclear Information System (INIS)

    Moore, G.; Shatashvili, S.

    2000-01-01

    We develop some useful techniques for integrating over Higgs branches in supersymmetric theories with 4 and 8 supercharges. In particular, we define a regularized volume for hyperkaehler quotients. We evaluate this volume for certain ALE and ALF spaces in terms of the hyperkaehler periods. We also reduce these volumes for a large class of hyperkaehler quotients to simpler integrals. These quotients include complex coadjoint orbits, instanton moduli spaces on R 4 and ALE manifolds, Hitchin spaces, and moduli spaces of (parabolic) Higgs bundles on Riemann surfaces. In the case of Hitchin spaces the evaluation of the volume reduces to a summation over solutions of Bethe ansatz equations for the non-linear Schroedinger system. We discuss some applications of our results. (orig.)

  8. Integrated and interprofessional care

    Science.gov (United States)

    Barr, Hugh

    2012-01-01

    No wonder two movements described in such similar terms are so often confused. One strives to knit services together, the other to cultivate collaborative practice amongst their workers. Dedicated though both of them are to the improvement of health and social care, integrated care falters without engaging the workforce actively as partners in change whilst interprofessional care falters without organisational support. Neither stands alone. Each depends on the other. PMID:23593049

  9. Integrated and interprofessional care

    Directory of Open Access Journals (Sweden)

    Hugh Barr

    2012-07-01

    Full Text Available No wonder two movements described in such similar terms are so often confused. One strives to knit services together, the other to cultivate collaborative practice amongst their workers.  Dedicated though both of them are to the improvement of health and social care, integrated care falters without engaging the workforce actively as partners in change whilst interprofessional care falters without organisational support. Neither stands alone. Each depends on the other.

  10. Integrative Behavioral Couple Therapy

    OpenAIRE

    Christensen, Andrew; Doss, Brian D.

    2017-01-01

    Integrative Behavioral Couple Therapy (IBCT) is based in part on traditional behavioral couple therapy but expands both the conceptualization of couple distress and of intervention. The efficacy of IBCT has been supported in three clinical trials, including one with five year follow-up. Additionally, the effectiveness of IBCT in the real world has been supported through a system-wide dissemination effort in the United States Department of Veteran’s Affairs. The reach of IBCT has also been ext...

  11. FRAPCON-3: Integral assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lanning, D.D.; Berna, G.A.; Berna, G.A.

    1997-12-01

    An integral assessment has been performed for the U.S. Nuclear Regulatory Commission by Pacific Northwest National Laboratory to quantify the predictive capabilities of FRAPCON-3, a steady-state fuel behavior code designed to analyze fuel behavior from beginning-of-life to burnup levels of 65 GWd/MTU. FRAPCON-3 code calculations are shown to compare satisfactorily to a pre-selected set of experimental data with steady-state operating conditions. 30 refs., 27 figs., 18 tabs.

  12. Integrable scalar cosmologies

    International Nuclear Information System (INIS)

    Fré, P.; Sorin, A.S.; Trigiante, M.

    2014-01-01

    The question whether the integrable one-field cosmologies classified in a previous paper by Fré, Sagnotti and Sorin can be embedded as consistent one-field truncations into Extended Gauged Supergravity or in N=1 supergravity gauged by a superpotential without the use of D-terms is addressed in this paper. The answer is that such an embedding is very difficult and rare but not impossible. Indeed, we were able to find two examples of integrable models embedded in supergravity in this way. Both examples are fitted into N=1 supergravity by means of a very specific and interesting choice of the superpotential W(z). The question whether there are examples of such an embedding in Extended Gauged Supergravity remains open. In the present paper, relying on the embedding tensor formalism we classified all gaugings of the N=2 STU model, confirming, in the absence on hypermultiplets, the uniqueness of the stable de Sitter vacuum found several years ago by Fré, Trigiante and Van Proeyen and excluding the embedding of any integrable cosmological model. A detailed analysis of the space of exact solutions of the first supergravity-embedded integrable cosmological model revealed several new features worth an in-depth consideration. When the scalar potential has an extremum at a negative value, the Universe necessarily collapses into a Big Crunch notwithstanding its spatial flatness. The causal structure of these Universes is quite different from that of the closed, positive curved, Universe: indeed, in this case the particle and event horizons do not coincide and develop complicated patterns. The cosmological consequences of this unexpected mechanism deserve careful consideration

  13. Integrated marketing communications

    OpenAIRE

    Camilleri, Mark Anthony

    2017-01-01

    Promotion is one of the four major elements of the marketing mix. Therefore, an integrated marketing communications (IMC) strategy consisting of a combination of promotional tools could be an essential element of the businesses’ overall marketing strategy. Different promotional tools could foster an increased awareness of a company’s products or services, inform people about features and benefits, and move them to make a purchase. In this light, this chapter examines these promotional tools, ...

  14. Integrated Reporting: Who Cares?

    OpenAIRE

    Cheok, Mei-Ing

    2013-01-01

    Integrated reporting (IR) is the latest in the evolution of corporate social and environmental disclosures. It seeks the holy grail of gaining mainstream acceptance in the investment community. I investigate and compare the perceptions of the investment community (considered IR’s primary target audience), sustainability experts and internal stakeholders (report producers), using Unilever as a case study. In this research, I find that while IR can help them make better long-term investment or ...

  15. Spatially Integrated Social Science

    OpenAIRE

    2004-01-01

    This document contains the chapter abstracts for the book—each chapter  illustrating how the spatial perspective adds value and insight to social science research, beyond what traditional non-spatial approaches might reveal.  The 21 chapters exemplify the founding principle for the Center for Spatially Integrated Social Science (CSISS)—that the analysis of social phenomena in space and time enhances our understanding of social processes. The chapters offer substantive empirical content for il...

  16. Integral Rehabilitation in Dentistry

    OpenAIRE

    Lamas Lara, César; Cirujano Dentista, Diplomado en Odontología Restauradora y Estética de la Facultad de Odontología de la UNMSM.; Paz Fernández, Juan José; Cirujano Dentista, Especialista en Rehabilitación Oral, Docente del Área de Rehabilitación Oral de la Facultad de Odontología de la UNMSM.; Paredes Coz, Gerson; Cirujano Dentista, Especialista en Rehabilitación Oral, Docente del Área de Rehabilitación Oral de la Facultad de Odontología de la UNMSM.; Angulo de la Vega, Giselle; Cirujano Dentista, Estudiante de la Especialidad de Rehabilitación Oral de la Facultad de Odontología de la UNMSM.; Cardoso Hernández, Sully; Estudiante de internado de la Facultad de Odontología de la UNMSM.

    2014-01-01

    Nowadays is fundamental the interrelationship of the diverse specialities of dentistry for the resolution of the treatments realized in the patients who come to the odontologic consultation, since the vision slanted of some area can deprive to offer a better possibility of treatment. Working with specialists in different areas carries to orientating adequately the treatments and to optimizing results. In the present article the integral rehabilitation of a patient is detailed by the participa...

  17. ALICE - ARC integration

    OpenAIRE

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva; Peters, Andreas; Siaz, Pablo

    2007-01-01

    AliEn or Alice Environment is the Gridware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructur...

  18. Respect: An Integrative Review.

    Science.gov (United States)

    Rewakowski, Carrie

    2018-04-01

    Feeling respected is a universal human experience. The notion of respect is ubiquitous and discussed at varying levels of discourse. An integrative review of the literature on the phenomenon of respect is discussed. Literature was reviewed from the disciplines of philosophy, psychology, sociology, business, theology, and nursing. Three themes emerged from this literature review: respect honors inherent worth, respect intentionally co-shapes identity, and respect emerges with earned admiration.

  19. INTEGRATION-INCLUSION

    OpenAIRE

    KERAMITCHIEVSKA-BILJANOVSKA Vesna; MITREVSKA Roberta; SABOLICH Nada

    2015-01-01

    By defining the terms, we would like to show that mentally disabled children cannot follow the regular educational process, in the same way children without learning disabilities can.The process of rehabilitation and education of disabled persons with different kind of disabilities, enables independent social integration and good quality of living in our country in the last 50 years; throw there is no need of changes in the inclusive education.

  20. Desarrollo Integral del Preescolar

    OpenAIRE

    Montes Hasslocher, Patricia Isabel

    2013-01-01

    Los niño cuyas edades oscilan entre los 2 y los 6 años de edad reciben el nombre de preescolares (etapa también conoconida como infancia temprana). Esta etapa es supremamente importante en la vida porque es aquí donde se sientan las bases del desarrollo posterior. Los adultos cuidadores deben acompañarlo afectuosa y permanentemente para logar su desarrollo integral, y estimularla adquisición de las metas del desarrollo

  1. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Chang, Y.I.

    1988-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics. 3 refs., 4 figs., 1 tab

  2. Legacy application integration architecture

    OpenAIRE

    Grom, Jure

    2009-01-01

    Information needs of modern businesses are constantly growing. Own development of a business information system is time consuming and expensive but, as an alternative, using smaller partial solutions doesn’t cover all user needs. Decision to buy a universal solution, often results in only part of it being actively and efficiently used. By application integration we manage to achieve efficient use of applications, since by linking them, we enable sharing of business logics among applications a...

  3. Regularization of divergent integrals

    OpenAIRE

    Felder, Giovanni; Kazhdan, David

    2016-01-01

    We study the Hadamard finite part of divergent integrals of differential forms with singularities on submanifolds. We give formulae for the dependence of the finite part on the choice of regularization and express them in terms of a suitable local residue map. The cases where the submanifold is a complex hypersurface in a complex manifold and where it is a boundary component of a manifold with boundary, arising in string perturbation theory, are treated in more detail.

  4. Integration i multikulturelle folkeskoler

    DEFF Research Database (Denmark)

    Gitz-Johansen, Thomas

    differentiere en befolkning, der kulturelt, socialt, sprogligt og identitetsmæssigt ikke var homogen. Integration kan derfor siges altid at have været en del af folkeskolens rolle. Denne rolle er dog blevet tilføjet nye nuancer i de senere årtier, hvor global migration har tilført det danske samfund og siden...... med minoritetsbaggrund må håndtere i skolehverdagen. Disse forskningsspørgsmål er beskrevet i kapitel ét sammen med min mere personlige motivation for at belyse disse spørgsmål. For at besvare de ovennævnte spørgsmål har jeg valgt at begive mig ud for at opleve og beskrive integration i hverdagen i...... sammenhæng. I kapitel to har jeg derfor, udover de metodiske redegørelser og overvejelser, inkluderet en beskrivelse af skolens rolle i forhold til samfundsmæssig integration udfra et henholdsvist identitetsmæssigt, et kulturel og et sprogligt perspektiv. Desuden har jeg fundet det nødvendigt at redegøre...

  5. Integral geometry and valuations

    CERN Document Server

    Solanes, Gil

    2014-01-01

    Valuations are finitely additive functionals on the space of convex bodies. Their study has become a central subject in convexity theory, with fundamental applications to integral geometry. In the last years there has been significant progress in the theory of valuations, which in turn has led to important achievements in integral geometry. This book originated from two courses delivered by the authors at the CRM and provides a self-contained introduction to these topics, covering most of the recent advances. The first part, by Semyon Alesker, is devoted to the theory of convex valuations, with emphasis on the latest developments. A special focus is put on the new fundamental structures of the space of valuations discovered after Alesker's irreducibility theorem. Moreover, the author describes the newly developed theory of valuations on manifolds. In the second part, Joseph H. G. Fu gives a modern introduction to integral geometry in the sense of Blaschke and Santaló, based on the notions and tools presented...

  6. Mechanical integrity of canisters

    International Nuclear Information System (INIS)

    Nilsson, Fred

    1992-12-01

    This document constitutes the final report from 'SKBs reference group for mechanical integrity of canisters for spent nuclear fuel'. A complete list of all reports initiated by the reference group can be found in the summary report in this document. The main task of the reference group has been to advice SKB regarding the choice (ranking of alternatives) of canister type for different types of storage. The choice should be based on requirements of impermeability for a given time period and identification of possible limiting mechanisms. The main conclusions from the work were: From mechanical point of view, low phosphorous oxygen free copper (Cu-OFP) is a preferred canisters material. It exhibits satisfactory ductility both during tensile and creep testing. The residual stresses in the canisters are of such a magnitude that the estimated time to creep rupture with the data obtained for the Cu-OFP material is essentially infinite. Based on the present knowledge of stress corrosion cracking of copper there appears to be a small risk for such to occur in the projected environment. This risk need some further study. Rock shear movements of the size of 10 cm should pose no direct threat to the integrity of the canisters. Considering mechanical integrity, the composite copper/steel canister is an advantageous alternative. The recommendations for further research included continued studies of the creep properties of copper and of stress corrosion cracking. However, the studies should focus more directly on the design and fabrication aspect of the canister

  7. IMMIGRANTS’ INTEGRATION MODELS

    Directory of Open Access Journals (Sweden)

    CARMEN UZLĂU

    2012-05-01

    Full Text Available In the context of the European population aging trend, and while the birth rate is still at a low level, the immigrants may contribute to the support of the EU economy and to finance the national social protection systems. But this would be possible only if they have been fully integrated in the host countries, the integration policies being a task of the national governments. The European Union may still offer support and stimulation through financing, policies coordination and good practices exchange facilitation. The new measures should encourage local level actions, including cooperation between local authorities, employers, migrants’ organizations, service providers and local population. Within the EU, there live 20.1 million immigrants (approximately 4% of the entire population coming from outside European area. An important element of the common EU policy on immigration is the one regarding the development of a policy on immigrants’ integration, which should provide a fair treatment within the member states, and guarantee rights and obligations comparable with the ones of the Union citizens.

  8. Integrative Bioengineering Institute

    Energy Technology Data Exchange (ETDEWEB)

    Eddington, David; Magin,L,Richard; Hetling, John; Cho, Michael

    2009-01-09

    Microfabrication enables many exciting experimental possibilities for medicine and biology that are not attainable through traditional methods. However, in order for microfabricated devices to have an impact they must not only provide a robust solution to a current unmet need, but also be simple enough to seamlessly integrate into standard protocols. Broad dissemination of bioMEMS has been stymied by the common aim of replacing established and well accepted protocols with equally or more complex devices, methods, or materials. The marriage of a complex, difficult to fabricate bioMEMS device with a highly variable biological system is rarely successful. Instead, the design philosophy of my lab aims to leverage a beneficial microscale phenomena (e.g. fast diffusion at the microscale) within a bioMEMS device and adapt to established methods (e.g. multiwell plate cell culture) and demonstrate a new paradigm for the field (adapt instead of replace). In order for the field of bioMEMS to mature beyond novel proof-of-concept demonstrations, researchers must focus on developing systems leveraging these phenomena and integrating into standard labs, which have largely been ignored. Towards this aim, the Integrative Bioengineering Institute has been established.

  9. Integrated genetic analysis microsystems

    International Nuclear Information System (INIS)

    Lagally, Eric T; Mathies, Richard A

    2004-01-01

    With the completion of the Human Genome Project and the ongoing DNA sequencing of the genomes of other animals, bacteria, plants and others, a wealth of new information about the genetic composition of organisms has become available. However, as the demand for sequence information grows, so does the workload required both to generate this sequence and to use it for targeted genetic analysis. Microfabricated genetic analysis systems are well poised to assist in the collection and use of these data through increased analysis speed, lower analysis cost and higher parallelism leading to increased assay throughput. In addition, such integrated microsystems may point the way to targeted genetic experiments on single cells and in other areas that are otherwise very difficult. Concomitant with these advantages, such systems, when fully integrated, should be capable of forming portable systems for high-speed in situ analyses, enabling a new standard in disciplines such as clinical chemistry, forensics, biowarfare detection and epidemiology. This review will discuss the various technologies available for genetic analysis on the microscale, and efforts to integrate them to form fully functional robust analysis devices. (topical review)

  10. The INTEGRAL mission

    DEFF Research Database (Denmark)

    Winkler, C.; Courvoisier, T.J.L.; Di Cocco, G.

    2003-01-01

    in the X-ray (3-35 keV) and optical (V-band, 550 nm) energy ranges. INTEGRAL carries two main gamma-ray instruments, the spectrometer SPI (Vedrenne et al. 2003)-optimized for the high-resolution gamma-ray line spectroscopy (20 keV-8 MeV), and the imager IBIS (Ubertini et al. 2003)-optimized for high......The ESA observatory INTEGRAL (International Gamma-Ray Astrophysics Laboratory) is dedicated to the fine spectroscopy (2.5 keV FWHM @ 1 MeV) and fine imaging (angular resolution: 12 arcmin FWHM) of celestial gamma-ray sources in the energy range 15 keV to 10 MeV with concurrent source monitoring...... Centre at ESTEC and the Science Data Centre near Geneva. INTEGRAL was launched on 17 October 2002. The observing programme is well underway and sky exposure (until June 2003) reaches similar to1800 ks in the Galactic plane. The prospects are excellent for the scientific community to observe the high...

  11. Classroom Integral Calculus: Some Useful Digressions When Teaching Integral Calculus.

    Science.gov (United States)

    Acosta, Daniel J.; Wills, Randall

    2002-01-01

    Outlines ideas and exercises for two topics that accompany the standard treatment of integral calculus. Emphasizes intuition to help facilitate student comprehension of the definite integral as a limit of Riemann Sums. (Author/MM)

  12. Counting master integrals. Integration by parts vs. functional equations

    International Nuclear Information System (INIS)

    Kniehl, Bernd A.; Tarasov, Oleg V.

    2016-01-01

    We illustrate the usefulness of functional equations in establishing relationships between master integrals under the integration-by-parts reduction procedure by considering a certain two-loop propagator-type diagram as an example.

  13. Quantum measure and integration theory

    International Nuclear Information System (INIS)

    Gudder, Stan

    2009-01-01

    This article begins with a review of quantum measure spaces. Quantum forms and indefinite inner-product spaces are then discussed. The main part of the paper introduces a quantum integral and derives some of its properties. The quantum integral's form for simple functions is characterized and it is shown that the quantum integral generalizes the Lebesgue integral. A bounded, monotone convergence theorem for quantum integrals is obtained and it is shown that a Radon-Nikodym-type theorem does not hold for quantum measures. As an example, a quantum-Lebesgue integral on the real line is considered.

  14. ASEAN: perspectives on economic integration: ASEAN in Asia economic integration

    OpenAIRE

    Shaobang Kang

    2009-01-01

    Asia is one continent which has the most dynamic and the fastest developing economies in the world. But Asia’s economic integration is developing too slowly and stands at the lowest level in the world. Many factors have affected Asia’s economic integration but, in the current global financial and economic crisis, it is necessary to strengthen Asian countries’ cooperation in finance, investment and trade to promote Asia’s economic integration. As the healthiest and most integrated regional org...

  15. Path-integral derivation of the complex ABCD Huygens integral

    International Nuclear Information System (INIS)

    Wright, E.M.; Garrison, J.C.

    1987-01-01

    The Huygens integral, or Green's function, for paraxial beam propagation in a generalized lenslike medium is derived as a Feynman path integral involving a summation over real rays. This formulation provides a physically intuitive understanding of the structure of the Green's function. The path integral is evaluated by introducing in a consistent manner the notion of complex rays, and the familiar result for the Huygens integral in terms of the complex ABCD matrix of the medium is obtained

  16. A survey of results on integral trees and integral graphs

    NARCIS (Netherlands)

    Wang, Ligong

    2005-01-01

    A graph $G$ is called {\\it integral} if all zeros of the characteristic polynomial $P(G,x)$ are integers. Our purpose is to determine or to characterize which graphs are integral. This problem was posed by Harary and Schwenk in 1974. In general, the problem of characterizing integral graphs seems to

  17. The effect of integrated reporting on integrated thinking between risk ...

    African Journals Online (AJOL)

    This study firstly assessed whether integrated reporting has enhanced integrated thinking between strategy and the risks and opportunities faced by the organisation. For this purpose, a web-based research questionnaire was sent to high-level implementers of integrated reporting at companies listed on the Johannesburg ...

  18. An integrating factor matrix method to find first integrals

    International Nuclear Information System (INIS)

    Saputra, K V I; Quispel, G R W; Van Veen, L

    2010-01-01

    In this paper we develop an integrating factor matrix method to derive conditions for the existence of first integrals. We use this novel method to obtain first integrals, along with the conditions for their existence, for two- and three-dimensional Lotka-Volterra systems with constant terms. The results are compared to previous results obtained by other methods.

  19. From integrated control to integrated farming, an experimental approach

    NARCIS (Netherlands)

    Vereijken, P.H.

    1989-01-01

    Integrated control or integrated pest management (IPM), as envisaged originally, is not being practised to any large extent in arable farming, notwithstanding considerable research efforts. The reasons for this are discussed. A more basic approach called integrated farming is suggested. Preliminary

  20. Perceptual integration without conscious access.

    Science.gov (United States)

    Fahrenfort, Johannes J; van Leeuwen, Jonathan; Olivers, Christian N L; Hogendoorn, Hinze

    2017-04-04

    The visual system has the remarkable ability to integrate fragmentary visual input into a perceptually organized collection of surfaces and objects, a process we refer to as perceptual integration. Despite a long tradition of perception research, it is not known whether access to consciousness is required to complete perceptual integration. To investigate this question, we manipulated access to consciousness using the attentional blink. We show that, behaviorally, the attentional blink impairs conscious decisions about the presence of integrated surface structure from fragmented input. However, despite conscious access being impaired, the ability to decode the presence of integrated percepts remains intact, as shown through multivariate classification analyses of electroencephalogram (EEG) data. In contrast, when disrupting perception through masking, decisions about integrated percepts and decoding of integrated percepts are impaired in tandem, while leaving feedforward representations intact. Together, these data show that access consciousness and perceptual integration can be dissociated.

  1. Measuring local integration in Ecuador

    Directory of Open Access Journals (Sweden)

    Santiago Cordova

    2017-10-01

    Full Text Available In 2014-15 UNHCR Ecuador developed an index to measure the degree to which refugees are integrated in their host country, using three main dimensions of local integration: legal, economic and socio-cultural.

  2. Integrated Compliance Information System (ICIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The purpose of ICIS is to meet evolving Enforcement and Compliance business needs for EPA and State users by integrating information into a single integrated data...

  3. Human-Systems Integration Processes

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of this project is to baseline a Human-Systems Integration Processes (HSIP) document as a companion to the NASA-STD-3001 and Human Integration Design...

  4. Common Systems Integration Lab (CSIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Common Systems Integration Lab (CSIL)supports the PMA-209 Air Combat Electronics Program Office. CSIL also supports development, test, integration and life cycle...

  5. Stochastic Integration in Abstract Spaces

    Directory of Open Access Journals (Sweden)

    J. K. Brooks

    2010-01-01

    -valued process (∫ called the stochastic integral. The Lebesgue space of these integrable processes is studied and convergence theorems are given. Extensions to general locally convex spaces are presented.

  6. Functional equations for Feynman integrals

    International Nuclear Information System (INIS)

    Tarasov, O.V.

    2011-01-01

    New types of equations for Feynman integrals are found. It is shown that Feynman integrals satisfy functional equations connecting integrals with different kinematics. A regular method is proposed for obtaining such relations. The derivation of functional equations for one-loop two-, three- and four-point functions with arbitrary masses and external momenta is given. It is demonstrated that functional equations can be used for the analytic continuation of Feynman integrals to different kinematic domains

  7. Domains of bosonic functional integrals

    International Nuclear Information System (INIS)

    Botelho, Luiz C.L.; Para Univ., Belem, PA

    1998-07-01

    We propose a mathematical framework for bosonic Euclidean quantum field functional integrals based on the theory of integration on the dual algebraic vector space of classical field sources. We present a generalization of the Minlos-Dao Xing theorem and apply it to determine exactly the domain of integration associated to the functional integral representation of the two-dimensional quantum electrodynamics Schwinger generating functional. (author)

  8. Integrated Education in Contemporary Poland

    Science.gov (United States)

    Apanel, Danuta

    2013-01-01

    This article presents the most important aspects, organizational principles and achievements in the field of integrated education in Poland. The author outlines the dynamics of the development of institutions of integrated education and institutions with integrated sections between 1989 and 2010. She describes the actual state of teaching…

  9. Financial integration and liquidity crises

    NARCIS (Netherlands)

    Castiglionesi, Fabio; Feriozzi, F.; Lorenzoni, G.

    2017-01-01

    This paper analyzes the effects of financial integration on the stability of the banking system. Financial integration allows banks in different regions to smooth local liquidity shocks by borrowing and lending on a common interbank market. We show under which conditions financial integration

  10. Spatial Grouping Determines Temporal Integration

    Science.gov (United States)

    Hermens, Frouke; Scharnowski, Frank; Herzog, Michael H.

    2009-01-01

    To make sense out of a continuously changing visual world, people need to integrate features across space and time. Despite more than a century of research, the mechanisms of features integration are still a matter of debate. To examine how temporal and spatial integration interact, the authors measured the amount of temporal fusion (a measure of…

  11. Understanding Sensory Integration. ERIC Digest.

    Science.gov (United States)

    DiMatties, Marie E.; Sammons, Jennifer H.

    This brief paper summarizes what is known about sensory integration and sensory integration dysfunction (DSI). It outlines evaluation of DSI, treatment approaches, and implications for parents and teachers, including compensatory strategies for minimizing the impact of DSI on a child's life. Review of origins of sensory integration theory in the…

  12. Parallel Handling of Integrity Constraints

    NARCIS (Netherlands)

    Grefen, P.W.P.J.; Flokstra, Jan; Apers, Peter M.G.

    1990-01-01

    Integrity constraints form an important part of a data model. Therefore, a complete integrity constraint handling subsystem is considered an important part of any modern DBMS. In implementing an integrity constraint handling subsystem, there are two major problem areas: providing enough

  13. Enclosing Solutions of Integral Equations

    DEFF Research Database (Denmark)

    Madsen, Kaj; NA NA NA Caprani, Ole; Stauning, Ole

    1996-01-01

    We present a method for enclosing the solution of an integral equation. It is assumed that a solution exists and that the corresponding integral operator T is a contraction near y. When solving the integral equation by iteration we obtain a result which is normally different from y because...

  14. Teaching Integration Applications Using Manipulatives

    Science.gov (United States)

    Bhatia, Kavita; Premadasa, Kirthi; Martin, Paul

    2014-01-01

    Calculus students' difficulties in understanding integration have been extensively studied. Research shows that the difficulty lies with students understanding of the definition of the definite integral as a limit of a Riemann sum and with the idea of accumulation inherent in integration. We have created a set of manipulatives and activities…

  15. An uncertain data integration system

    NARCIS (Netherlands)

    Ayat, N.; Afsarmanesh, H.; Akbarinia, R.; Valduriez, P.

    2012-01-01

    Data integration systems offer uniform access to a set of autonomous and heterogeneous data sources. An important task in setting up a data integration system is to match the attributes of the source schemas. In this paper, we propose a data integration system which uses the knowledge implied within

  16. On the equality of integrals

    Czech Academy of Sciences Publication Activity Database

    Mesiar, Radko; Li, J.; Ouyang, Y.

    2017-01-01

    Roč. 393, č. 1 (2017), s. 82-90 ISSN 0020-0255 Institutional support: RVO:67985556 Keywords : Choquet integral * Concave integral * Minimal atom * Monotone measure * Pan-integral Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 4.832, year: 2016 http://library.utia.cas.cz/separaty/2017/E/mesiar-0477101.pdf

  17. Integrated material accountancy system

    International Nuclear Information System (INIS)

    Calabozo, M.; Buiza, A.

    1991-01-01

    In this paper we present the system that we are actually using for Nuclear Material Accounting and Manufacturing Management in our UO 2 Fuel Fabrication Plant located at Juzbado, Salamanca, Spain. The system is based mainly on a real time data base which gather data for all the operations performed in our factory from UO 2 powder reception to fuel assemblies shipment to the customers. The accountancy is just an important part of the whole integrated system covering all the aspects related to manufacturing: planning, traceability, Q.C. analysis, production control and accounting data

  18. An integrated CANDU system

    International Nuclear Information System (INIS)

    Donnelly, J.

    1982-09-01

    Twenty years of experience have shown that the early choices of heavy water as moderator and natural uranium as fuel imposed a discipline on CANDU design that has led to outstanding performance. The integrated structure of the industry in Canada, incorporating development, design, supply, manufacturing, and operation functions, has reinforced this performance and has provided a basis on which to continue development in the future. These same fundamental characteristics of the CANDU program open up propsects for further improvements in economy and resource utilization through increased reactor size and the development of the thorium fuel cycle

  19. Continuous Integration in CFMGR

    CERN Document Server

    Frohlingsdorf, David

    2017-01-01

    Cfmgr is a managing tool for network devices. At the moment there is no way to automatically check the working behaviour of the tool, meaning that a lot of effort is spend into manually testing the tool after an update. During my stay at CERN I developed a black-box testing framework for Cfmgr according to Continuous Integration practices and successfully deployed the framework using Jenkins and Docker. This report discusses in detail how the framework works and how it can be configured, and equally gives a broad problem description and outlines future work directions.

  20. Multifuctional integrated sensors (MFISES).

    Energy Technology Data Exchange (ETDEWEB)

    Homeijer, Brian D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Roozeboom, Clifton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    Many emerging IoT applications require sensing of multiple physical and environmental parameters for: completeness of information, measurement validation, unexpected demands, improved performance. For example, a typical outdoor weather station measures temperature, humidity, barometric pressure, light intensity, rainfall, wind speed and direction. Existing sensor technologies do not directly address the demand for cost, size, and power reduction in multi-paramater sensing applications. Industry sensor manufacturers have developed integrated sensor systems for inertial measurements that combine accelerometers, gyroscopes, and magnetometers, but do not address environmental sensing functionality. In existing research literature, a technology gap exists between the functionality of MEMS sensors and the real world applications of the sensors systems.

  1. Integral Combinations of Heavisides

    Czech Academy of Sciences Publication Activity Database

    Kainen, P.C.; Kůrková, Věra; Vogt, A.

    2010-01-01

    Roč. 283, č. 6 (2010), s. 854-878 ISSN 0025-584X R&D Projects: GA ČR GA201/05/0557; GA ČR GA201/08/1744 Institutional research plan: CEZ:AV0Z10300504 Keywords : feedforward neural network * perceptron * heaviside function * plane wave * integral formula * radon transform * Green’s function for iterated Laplacians * order of vanishing * function of controlled decay Subject RIV: BA - General Mathematics Impact factor: 0.653, year: 2010

  2. Integrated Assessment Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Edmonds, James A.; Calvin, Katherine V.; Clarke, Leon E.; Janetos, Anthony C.; Kim, Son H.; Wise, Marshall A.; McJeon, Haewon C.

    2012-10-31

    This paper discusses the role of Integrated Assessment models (IAMs) in climate change research. IAMs are an interdisciplinary research platform, which constitutes a consistent scientific framework in which the large-scale interactions between human and natural Earth systems can be examined. In so doing, IAMs provide insights that would otherwise be unavailable from traditional single-discipline research. By providing a broader view of the issue, IAMs constitute an important tool for decision support. IAMs are also a home of human Earth system research and provide natural Earth system scientists information about the nature of human intervention in global biogeophysical and geochemical processes.

  3. Integrated Energy Design

    DEFF Research Database (Denmark)

    Brunsgaard, Camilla; Dvořáková, Pavla; Wyckmans, Annemie

    2014-01-01

    In Europe, energy and climate policies started to take shape from the 1990s onwards culminating with the ambitious 20e20e20 climate goals and the Low-Carbon Europe roadmap 2050. The European Commission empower the importance of achieving the objective of the recast Directive on energy performance...... of buildings (EPBD) that new buildings built from 2021 onwards will have to be nearly zeroenergy buildings. The general belief is that the energy performance optimization of buildings requires an integrated design approach and cross-disciplinary teamwork to optimize the building’s energy use and quality...

  4. Integrable billiards and quadrics

    International Nuclear Information System (INIS)

    Dragovic, Vladimir I; Radnovic, Milena

    2010-01-01

    Billiards inside quadrics are considered as integrable dynamical systems with a rich geometric structure. The two-way interaction between the dynamics of billiards and the geometry of pencils of quadrics in an arbitrary dimension is considered. Several well-known classical and modern genus-1 results are generalized to arbitrary dimension and genus, such as: the Poncelet theorem, the Darboux theorem, the Weyr theorem, and the Griffiths-Harris space theorem. A synthetic approach to higher-genera addition theorems is presented. Bibliography: 77 titles.

  5. Frontal Integration and Coping

    DEFF Research Database (Denmark)

    Larsen, Torben

    2012-01-01

    and risk minimizing Rationalists dominated by dlPFC • R correlates both with your own level of education and that of your parents 3 Conclusion: Empirical verification of the first derivative of NeM uncovers four different coping patterns within the range of normal behaviors with an obvious analogue...... to the classical tempers. In prospect, differentiating the Frontal integration pattern by temper (General risk attitude) opens an evidence-based pathway for individually tailored neural training towards advanced social objectives as multidisciplinary collaboration and healthy living. References 1. Larsen T...... et al. Gender difference in neural response to psychological stress. SCAN 2 2007, 227–233...

  6. Linear integrated circuits

    CERN Document Server

    Carr, Joseph

    1996-01-01

    The linear IC market is large and growing, as is the demand for well trained technicians and engineers who understand how these devices work and how to apply them. Linear Integrated Circuits provides in-depth coverage of the devices and their operation, but not at the expense of practical applications in which linear devices figure prominently. This book is written for a wide readership from FE and first degree students, to hobbyists and professionals.Chapter 1 offers a general introduction that will provide students with the foundations of linear IC technology. From chapter 2 onwa

  7. Integrated tunable CMOS laser.

    Science.gov (United States)

    Creazzo, Timothy; Marchena, Elton; Krasulick, Stephen B; Yu, Paul K L; Van Orden, Derek; Spann, John Y; Blivin, Christopher C; He, Lina; Cai, Hong; Dallesasse, John M; Stone, Robert J; Mizrahi, Amit

    2013-11-18

    An integrated tunable CMOS laser for silicon photonics, operating at the C-band, and fabricated in a commercial CMOS foundry is presented. The III-V gain medium section is embedded in the silicon chip, and is hermetically sealed. The gain section is metal bonded to the silicon substrate creating low thermal resistance into the substrate and avoiding lattice mismatch problems. Optical characterization shows high performance in terms of side mode suppression ratio, relative intensity noise, and linewidth that is narrow enough for coherent communications.

  8. On an integral transform

    Directory of Open Access Journals (Sweden)

    D. Naylor

    1988-01-01

    Full Text Available A formula of inversion is established for an integral transform whose kernel is the Bessel function Ju(kr where r varies over the finite interval (0,a and the order u is taken to be the eigenvalue parameter. When this parameter is large the Bessel function behaves for varying r like the power function ru and by relating the Bessel functions to their corresponding power functions the proof of the inversion formula can be reduced to one depending on the Mellin inversion theorem.

  9. Symbolism in European Integration

    DEFF Research Database (Denmark)

    Manners, Ian

    2011-01-01

    Ernst Haas observed over fifty years ago that ‘United Europe' is a resilient, adaptable, unifying, and yet unspecified symbol'. It is precisely this adaptability and ambiguity that has ensures the continuing importance of European studies as a means of understanding ‘the remarkable social...... of social transformation involved' (Calhoun 2003: 18). This article will consider the role of symbolism in European integration as part of answering Craig Calhoun's call for a means of transcending specific regimes of analysis in order to advance European studies....

  10. Future integrated design environments

    DEFF Research Database (Denmark)

    Christiansson, Per; Svidt, Kjeld; Sørensen, Kristian Birch

    2009-01-01

    on the development. Among the most important are missing ontologies both on business and Web/Internet service levels as well as their interrelations, poor user involvement in needs and requirements formulations on new ICT tools as well as in continuous user involvement in design and evaluation of new user...... to be increased. The paper presents a roadmap for development of future Integrated Building Design Systems (IBDS) with end-user participation. Methods for development of tools supporting creative and innovative building design with end-user participation is taking into account, including methods for capture...

  11. Camel enterprise integration cookbook

    CERN Document Server

    Cranton, Scott

    2013-01-01

    This book is written in a Cookbook style with short recipes showing developers how to effectively implement EIP without breaking everything in the process. It is concise and to the point, and it helps developers get their data flowing between different components without the need to read through page upon page of theory, while also enabling the reader to learn how to create exciting new projects.Camel Enterprise Integration Cookbook is intended for developers who have some familiarity with Apache Camel and who want a quick lookup reference to practical, proven tips on how to perform common tas

  12. Blazars with INTEGRAL

    Czech Academy of Sciences Publication Activity Database

    Hudec, René; Blažek, Martin; Kocka, Matúš; Pian, E.

    2009-01-01

    Roč. 18, 3-4 (2009), s. 327-335 ISSN 1392-0049. [INTEGRAL/BART workshop 2009. Karlovy Vary, 26.03.2009-29.03.2009] R&D Project s: GA ČR GA205/08/1207 Grant - others:ESA(XE) ESA-PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Keywords : active galaxies * blazars * gamma rays Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.032, year: 2009

  13. Integrated Structural Design Education

    DEFF Research Database (Denmark)

    Bjerregaard Jensen, Lotte; Almegaard, Henrik

    2011-01-01

    In Environmental Impact Assessment (EIA), the environment is broadly defined and includes not only quantifiable aspects, but also social conditions, scenic beauty, traffic, cultural heritage, and commercial development. A successful bridge design must comply with all of these demands according...... landscaping and structural design. The integrated courses create a setting for learning about the design of large-scale structures and involve geometry, statics, computer simulation, graphical design and landscape architecture. Together, they educate engineers who can take part in the early design phases...... of a project, function well in design teams, and comply with EU EIA demands....

  14. Integrated test schedule for buried waste integrated demonstration

    International Nuclear Information System (INIS)

    Brown, J.T.; McDonald, J.K.

    1992-05-01

    The Integrated Test Schedule incorporates the various schedules the Buried Waste Integrated Demonstration (BWID) supports into one document. This document contains the Federal Facilities Agreement and Consent Order schedules for the Idaho National Engineering Laboratory, Hanford Reservation, Oak Ridge Reservation, and Fernald Environmental Materials Center. Included in the Integrated Test Schedule is the Buried Waste Integrated Demonstration ''windows of opportunity'' schedule. The ''windows of opportunity'' schedule shows periods of time in which Buried Waste Integrated Demonstration Program-sponsored technology demonstrations could support key decisions in the Federal Facilities Agreement and Consent Order. Schedules for the Buried Waste Integrated Demonstration-sponsored technology task plans are categorized by technology area and divided by current fiscal year and out-year. Total estimated costs for Buried Waste Integrated Demonstration-sponsored Technology Task Plans for FY-92 through FY-97 are $74.756M

  15. Decision-Making for Supply Chain Integration Supply Chain Integration

    CERN Document Server

    Lettice, Fiona; Durowoju, Olatunde

    2012-01-01

    Effective supply chain integration, and the tight co-ordination it creates, is an essential pre-requisite for successful supply chain management.  Decision-Making for Supply Chain Integration is a practical reference on recent research in the area of supply chain integration focusing on distributed decision-making problems. Recent applications of various decision-making tools for integrating supply chains are covered including chapters focusing on: •Supplier selection, pricing strategy and inventory decisions in multi-level supply chains, •RFID-enabled distributed decision-making, •Operational risk issues and time-critical decision-making for sensitive logistics nodes, Modelling end to end processes to improve supply chain integration, and •Integrated systems to improve service delivery and optimize resource use. Decision-Making for Supply Chain Integration provides an insight into the tools and methodologies of this field with support from real-life case studies demonstrating successful application ...

  16. Integrating Nephelometer Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Uin, J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-01

    The Integrating Nephelometer (Figure 1) is an instrument that measures aerosol light scattering. It measures aerosol optical scattering properties by detecting (with a wide angular integration – from 7 to 170°) the light scattered by the aerosol and subtracting the light scattered by the carrier gas, the instrument walls and the background noise in the detector (zeroing). Zeroing is typically performed for 5 minutes every day at midnight UTC. The scattered light is split into red (700 nm), green (550 nm), and blue (450 nm) wavelengths and captured by three photomultiplier tubes. The instrument can measure total scatter as well as backscatter only (from 90 to 170°) (Heintzenberg and Charlson 1996; Anderson et al. 1996; Anderson and Ogren 1998; TSI 3563 2015) At ARM (Atmospheric Radiation Measurement), two identical Nephelometers are usually run in series with a sample relative humidity (RH) conditioner between them. This is possible because Nephelometer sampling is non-destructive and the sample can be passed on to another instrument. The sample RH conditioner scans through multiple RH values in cycles, treating the sample. This kind of setup allows to study how aerosol particles’ light scattering properties are affected by humidification (Anderson et al. 1996). For historical reasons, the two Nephelometers in this setup are labeled “wet” and “dry”, with the “dry” Nephelometer usually being the one before the conditioner and sampling ambient air (the names are switched for the MAOS measurement site due to the high RH of the ambient air).

  17. Peptide Integrated Optics.

    Science.gov (United States)

    Handelman, Amir; Lapshina, Nadezda; Apter, Boris; Rosenman, Gil

    2018-02-01

    Bio-nanophotonics is a wide field in which advanced optical materials, biomedicine, fundamental optics, and nanotechnology are combined and result in the development of biomedical optical chips. Silk fibers or synthetic bioabsorbable polymers are the main light-guiding components. In this work, an advanced concept of integrated bio-optics is proposed, which is based on bioinspired peptide optical materials exhibiting wide optical transparency, nonlinear and electrooptical properties, and effective passive and active waveguiding. Developed new technology combining bottom-up controlled deposition of peptide planar wafers of a large area and top-down focus ion beam lithography provides direct fabrication of peptide optical integrated circuits. Finding a deep modification of peptide optical properties by reconformation of biological secondary structure from native phase to β-sheet architecture is followed by the appearance of visible fluorescence and unexpected transition from a native passive optical waveguiding to an active one. Original biocompatibility, switchable regimes of waveguiding, and multifunctional nonlinear optical properties make these new peptide planar optical materials attractive for application in emerging technology of lab-on-biochips, combining biomedical photonic and electronic circuits toward medical diagnosis, light-activated therapy, and health monitoring. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. [Integrated quality assurance].

    Science.gov (United States)

    Bögel, K; Stöhr, K

    1994-07-01

    The definition of terms and connotation of "Quality", "Quality Assurance" and "Integration" lead to an analysis and understanding of inhibiting and fostering factors of the "Health Triad" of people, animals and environment. Although "Quality" is largely or ultimately determined by the consumer, there are considerable differences as this term is applied by (a) the individual consumer, (b) the dynamic producer defending or gaining markets, (c) those engaged in traditional product manufacturing, or (d) governments setting (minimum) requirements for the sake of free trade. "Quality Assurance" offers cooperation of partners all along the food chain from "pasture to table". The managerial process turned into a continuum of responsibility and agreement on processes and product characteristics. This overcomes the disadvantages of strategies stressing distinct defense barriers. In practice this philosophy of a predominant role of defence barriers proved largely partnership destructive, in that it permitted to shift responsibilities for failures and to claim administrative competence according to momentary situations and interests. "Integrated Quality Assurance" means mutual agreement of two or more partners along the food chain (e. g. feed producers, farmers, animal health industry, veterinarians and food processors) on product characteristics and production methods. It involves essential system elements including facilities, materials, manpower, information, transport, management etc. Different principles and procedures of quality assurance have been introduced in practice, including agriculture and food processing. These different approaches are not mutually exclusive but largely of complementary nature.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Semiconductor integrated circuits

    International Nuclear Information System (INIS)

    Michel, A.E.; Schwenker, R.O.; Ziegler, J.F.

    1979-01-01

    An improved method involving ion implantation to form non-epitaxial semiconductor integrated circuits. These are made by forming a silicon substrate of one conductivity type with a recessed silicon dioxide region extending into the substrate and enclosing a portion of the silicon substrate. A beam of ions of opposite conductivity type impurity is directed at the substrate at an energy and dosage level sufficient to form a first region of opposite conductivity within the silicon dioxide region. This impurity having a concentration peak below the surface of the substrate forms a region of the one conductivity type which extends from the substrate surface into the first opposite type region to a depth between the concentration peak and the surface and forms a second region of opposite conductivity type. The method, materials and ion beam conditions are detailed. Vertical bipolar integrated circuits can be made this way when the first opposite type conductivity region will function as a collector. Also circuits with inverted bipolar devices when this first region functions as a 'buried'' emitter region. (U.K.)

  20. The integral fast reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1987-01-01

    On April 3rd, 1986, two demonstrations of the inherent capability of sodium-cooled fast reactors to survive unprotected loss of cooling accidents were carried out on the experimental sodium-cooled power reactor, EBR-II, on the Idaho site of Argonne National Laboratory. Transients potentially of the most serious kind, one an unprotected loss of flow, the other an unprotected loss of heat sink, both initiated from full power. In both cases the reactor quietly shut itself down, without damage of any kind. These tests were a part of the on-going development program at Argonne to develop an advanced reactor with significant new inherent safety characteristics. Called the integral fast reactor, or IFR, the basic thrust is to develop everything that is needed for a complete nuclear power system - reactor, closed fuel cycle, and waste processing - as a single optimized entity, and, for simplicity in concept, as an integral part of a single plant. The particular selection of reactor materials emphasizes inherent safety characteristics also makes possible a simplified close fuel cycle and waste process improvements. The paper describes the IFR concept, the inherent safety, tests, and status of IFR development today

  1. Integrated Medical Model Overview

    Science.gov (United States)

    Myers, J.; Boley, L.; Foy, M.; Goodenow, D.; Griffin, D.; Keenan, A.; Kerstman, E.; Melton, S.; McGuire, K.; Saile, L.; hide

    2015-01-01

    The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project.

  2. Pressure vessel integrity 1991

    International Nuclear Information System (INIS)

    Bhandari, S.; Doney, R.O.; McDonald, M.S.; Jones, D.P.; Wilson, W.K.; Pennell, W.E.

    1991-01-01

    This volume contains papers relating to the structural integrity assessment of pressure vessels and piping, with special emphasis on nuclear industry applications. The papers were prepared for technical sessions developed under the sponsorship of the ASME Pressure Vessels and Piping Division Committees for Codes and Standards, Computer Technology, Design and Analysis, and Materials Fabrication. They were presented at the 1991 Pressure Vessels and Piping Division Conference in San Diego, California, June 23-27. The primary objective of the sponsoring organization is to provide a forum for the dissemination and discussion of information on development and application of technology for the structural integrity assessment of pressure vessels and piping. This publication includes contributions from authors from Australia, France, Japan, Sweden, Switzerland, the United Kingdom, and the United States. The papers here are organized in six sections, each with a particular emphasis as indicated in the following section titles: Fracture Technology Status and Application Experience; Crack Initiation, Propagation and Arrest; Ductile Tearing; Constraint, Stress State, and Local-Brittle-Zones Effects; Computational Techniques for Fracture and Corrosion Fatigue; and Codes and Standards for Fatigue, Fracture and Erosion/Corrosion

  3. USGS integrated drought science

    Science.gov (United States)

    Ostroff, Andrea C.; Muhlfeld, Clint C.; Lambert, Patrick M.; Booth, Nathaniel L.; Carter, Shawn L.; Stoker, Jason M.; Focazio, Michael J.

    2017-06-05

    Project Need and OverviewDrought poses a serious threat to the resilience of human communities and ecosystems in the United States (Easterling and others, 2000). Over the past several years, many regions have experienced extreme drought conditions, fueled by prolonged periods of reduced precipitation and exceptionally warm temperatures. Extreme drought has far-reaching impacts on water supplies, ecosystems, agricultural production, critical infrastructure, energy costs, human health, and local economies (Milly and others, 2005; Wihlite, 2005; Vörösmarty and others, 2010; Choat and others, 2012; Ledger and others, 2013). As global temperatures continue to increase, the frequency, severity, extent, and duration of droughts are expected to increase across North America, affecting both humans and natural ecosystems (Parry and others, 2007).The U.S. Geological Survey (USGS) has a long, proven history of delivering science and tools to help decision-makers manage and mitigate effects of drought. That said, there is substantial capacity for improved integration and coordination in the ways that the USGS provides drought science. A USGS Drought Team was formed in August 2016 to work across USGS Mission Areas to identify current USGS drought-related research and core capabilities. This information has been used to initiate the development of an integrated science effort that will bring the full USGS capacity to bear on this national crisis.

  4. The integral fast reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1987-01-01

    On April 3rd, 1986, two dramatic demonstrations of the inherent capability of sodium-cooled fast reactors to survive unprotected loss of cooling accidents were carried out on the experimental sodium-cooled power reactor, EBR-II, on the Idaho site of Argonne National Laboratory. Transients potentially of the most serious kind, one an unprotected loss of flow, the other an unprotected loss of heat sink, both initiated from full power. In both cases the reactor quietly shut itself down, without damage of any kind. These tests were a part of the on-going development program at Argonne to develop an advanced reactor with significant new inherent safety characteristics. Called the Integral Fast Reactor, or IFR, the basic thrust is to develop everything that is needed for a complete nuclear power system - reactor, closed fuel cycle, and waste processing - as a single optimized entity, and, for simplicity in concept, as an integral part of a single plant. The particular selection of reactor materials emphasizes inherent safety characteristics and also makes possible a simplified closed fuel cycle and waste process improvements

  5. Integrable Floquet dynamics

    Directory of Open Access Journals (Sweden)

    Vladimir Gritsev, Anatoli Polkovnikov

    2017-06-01

    Full Text Available We discuss several classes of integrable Floquet systems, i.e. systems which do not exhibit chaotic behavior even under a time dependent perturbation. The first class is associated with finite-dimensional Lie groups and infinite-dimensional generalization thereof. The second class is related to the row transfer matrices of the 2D statistical mechanics models. The third class of models, called here "boost models", is constructed as a periodic interchange of two Hamiltonians - one is the integrable lattice model Hamiltonian, while the second is the boost operator. The latter for known cases coincides with the entanglement Hamiltonian and is closely related to the corner transfer matrix of the corresponding 2D statistical models. We present several explicit examples. As an interesting application of the boost models we discuss a possibility of generating periodically oscillating states with the period different from that of the driving field. In particular, one can realize an oscillating state by performing a static quench to a boost operator. We term this state a "Quantum Boost Clock". All analyzed setups can be readily realized experimentally, for example in cod atoms.

  6. Buried Waste Integrated Demonstration

    International Nuclear Information System (INIS)

    1994-03-01

    The Buried Waste Integrated Demonstration (BWID) supports the applied research, development, demonstration, and evaluation of a suite of advanced technologies that offer promising solutions to the problems associated with the remediation of buried waste. BWID addresses the difficult remediation problems associated with DOE complex-wide buried waste, particularly transuranic (TRU) contaminated buried waste. BWID has implemented a systems approach to the development and demonstration of technologies that will characterize, retrieve, treat, and dispose of DOE buried wastes. This approach encompasses the entire remediation process from characterization to post-monitoring. The development and demonstration of the technology is predicated on how a technology fits into the total remediation process. To address all of these technological issues, BWID has enlisted scientific expertise of individuals and groups from within the DOE Complex, as well as experts from universities and private industry. The BWID mission is to support development and demonstration of a suite of technologies that, when integrated with commercially-available technologies, forms a comprehensive, remediation system for the effective and efficient remediation of buried waste throughout the DOE Complex. BWID will evaluate and validate demonstrated technologies and transfer this information and equipment to private industry to support the Office of Environmental Restoration (ER), Office of Waste Management (WM), and Office of Facility Transition (FT) remediation planning and implementation activities

  7. A conceptual framework of integrity

    Directory of Open Access Journals (Sweden)

    Antoni Barnard

    2008-10-01

    Full Text Available This article reports on the fndings of a qualitative study in which the construction of integrity of some business leaders was explored. Data were gathered through ten in-depth interviews with six South African business leaders commended to be champions of integrity. A grounded-theory approach to the data analysis elicited fve themes. These themes and their interrelatedness are discussed in this article and a conceptual framework of integrity is proposed. Integrity is conceptualised as a multifaceted and dynamic construct based on a moral foundation and inner drive that is managed by cognitive and affective processes manifesting various integrity-related behaviours.

  8. Integration of European Bond Markets

    DEFF Research Database (Denmark)

    Christiansen, Charlotte

    2014-01-01

    I investigate the time variation in the integration of EU government bond markets. The integration is measured by the explanatory power of European factor portfolios for the individual bond markets for each year. The integration of the government bond markets is stronger for EMU than non-EMU memb......-EMU members and stronger for old than new EU members. For EMU countries, the integration is weaker the lower the credit rating is. During the recent crisis periods, the integration is weaker, particularly for EMU countries....

  9. System integration for radiation records

    International Nuclear Information System (INIS)

    Lawson, B.J.; Farrell, L.; Meacham, C.; Tapio, J.

    1994-01-01

    System integration is the process where through networking and/or software development, necessary business information is available in a common computing environment. System integration is becoming an important objective for many businesses. System integration can improve productivity and efficiency, reduce redundant stored information and errors, and improve availability of information. This paper will discuss the information flow in a radiation health environment, and how system integration can help. Information handled includes external dosimetry and internal dosimetry. The paper will focus on an ORACLE based system integration software product

  10. Nonlinear integral operators and applications

    CERN Document Server

    Musielak, Julian; Bardaro, Carlo

    2003-01-01

    In 1903 Fredholm published his famous paper on integral equations. Since then linear integral operators have become an important tool in many areas, including the theory of Fourier series and Fourier integrals, approximation theory and summability theory, and the theory of integral and differential equations. As regards the latter, applications were soon extended beyond linear operators. In approximation theory, however, applications were limited to linear operators mainly by the fact that the notion of singularity of an integral operator was closely connected with its linearity. This book represents the first attempt at a comprehensive treatment of approximation theory by means of nonlinear integral operators in function spaces. In particular, the fundamental notions of approximate identity for kernels of nonlinear operators and a general concept of modulus of continuity are developed in order to obtain consistent approximation results. Applications to nonlinear summability, nonlinear integral equations and ...

  11. Line integral on engineering mathematics

    Science.gov (United States)

    Wiryanto, L. H.

    2018-01-01

    Definite integral is a basic material in studying mathematics. At the level of calculus, calculating of definite integral is based on fundamental theorem of calculus, related to anti-derivative, as the inverse operation of derivative. At the higher level such as engineering mathematics, the definite integral is used as one of the calculating tools of line integral. the purpose of this is to identify if there is a question related to line integral, we can use definite integral as one of the calculating experience. The conclusion of this research says that the teaching experience in introducing the relation between both integrals through the engineer way of thinking can motivate and improve students in understanding the material.

  12. Duality for discrete integrable systems

    International Nuclear Information System (INIS)

    Quispel, G R W; Capel, H W; Roberts, J A G

    2005-01-01

    A new class of discrete dynamical systems is introduced via a duality relation for discrete dynamical systems with a number of explicitly known integrals. The dual equation can be defined via the difference of an arbitrary linear combination of integrals and its upshifted version. We give an example of an integrable mapping with two parameters and four integrals leading to a (four-dimensional) dual mapping with four parameters and two integrals. We also consider a more general class of higher-dimensional mappings arising via a travelling-wave reduction from the (integrable) MKdV partial-difference equation. By differencing the trace of the monodromy matrix we obtain a class of novel dual mappings which is shown to be integrable as level-set-dependent versions of the original ones

  13. Integrated management system

    International Nuclear Information System (INIS)

    Florescu, N.

    2003-01-01

    A management system is developed in order to reflect the needs of the business and to ensure that the objectives of the organization will be achieved. The process model and each individual process within the system then needs to identify the drives or requirements from external customers and stakeholders, regulations, and standards such as ISO and 50-C-Q. The processes are then developed to address these drivers. Developing the process in this way makes it fully integrated and capable of incorporating any new requirements. The International Standard (ISO 9000:2000) promotes the adoption of a process approach when developing, implementing and improving the effectiveness of a quality management system to enhance customer satisfaction by meeting customer requirements. The IAEA Code recognizes that the entire work is a process which can be planned, assessed and improved. For an organization to function effectively, numerous linked activities have to be identified and managed. By definition a process is an activity that using resources and taking into account all the constraints imposed executes the necessary operations which transform the inputs in outcomes. Running a system of processes within an organization, identification of the interaction between the processes and their management can be referred to as a 'process approach'. The advantage of such an approach is the ensuring of the ongoing control over the linkage between the individual processes composing the system as well as over their combination and interaction. Developing a management system implies: identification of the process which delivers Critical Success Factor (CSFs) of the business; identifying the support processes enabling the CSFs to be accomplished; identifying the processes that deliver the business fundamentals. An integrated management system should include all activities not only those related to Quality, Health and Safety. When developing an IMS it is necessary to identify all of the drivers

  14. Integrative Behavioral Couple Therapy.

    Science.gov (United States)

    Christensen, Andrew; Doss, Brian D

    2017-02-01

    Integrative Behavioral Couple Therapy (IBCT) is based in part on traditional behavioral couple therapy but expands both the conceptualization of couple distress and of intervention. The efficacy of IBCT has been supported in three clinical trials, including one with five year follow-up. Additionally, the effectiveness of IBCT in the real world has been supported through a system-wide dissemination effort in the United States Department of Veteran's Affairs. The reach of IBCT has also been extended through an online program, www.OurRelationship.com, based on IBCT. A nationwide clinical trial with a representative sample of the US population demonstrated the effectiveness of this program on both relationship and individual variables.

  15. Black silicon integrated aperture

    Science.gov (United States)

    Liu, Tianbo; Dickensheets, David L.

    2017-10-01

    This paper describes the incorporation of nanotextured black silicon as an optical absorbing material into silicon-based micro-optoelectromechanical systems devices to reduce stray light and increase optical contrast during imaging. Black silicon is created through a maskless dry etch process and characterized for two different etch conditions, a cold etch performed at 0°C and a cryogenic etch performed at -110°C. We measure specular reflection at visible wavelengths to be black velvet paint used to coat optical baffles and compare favorably with other methods to produce black surfaces from nanotextured silicon or using carbon nanotubes. We illustrate the use of this material by integrating a black silicon aperture around the perimeter of a deformable focus-control mirror. Imaging results show a significant improvement in contrast and image fidelity due to the effective reduction in stray light achieved with the self-aligned black aperture.

  16. An Integrated Design Process

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2010-01-01

    Present paper is placed in the discussion about how sustainable measures are integrated in the design process by architectural offices. It presents results from interviews with four leading Danish architectural offices working with sustainable architecture and their experiences with it, as well...... as the requirements they meet in terms of how to approach the design process – especially focused on the early stages like a competition. The interviews focus on their experiences with working in multidisciplinary teams and using digital tools to support their work with sustainable issues. The interviews show...... that there is a difference in the experiences of the different offices. Architects taking an active part in the development of projects and tools in general have a better understanding of how to approach this. It is of course not surprising, because of a focused strategy towards this. However the most important thing...

  17. Integrated nuclear reactor

    International Nuclear Information System (INIS)

    Pales, I.; Hasko, V.

    1984-01-01

    The reactor is provided with an integrated circuit of primary medium circulation with hydraulic pump drive. The pump drive which is a blade hydraulic facility is placed in the reactor vessel together with the pump. The primary medium flows through the core and enters the inter-tube space of the secondary circuit heat exchanger. The secondary circuit medium is supplied under the bottom tube plate with a supply pipe. From it the flow of secondary medium is directed to the blades of the hydraulic facility, e.g. the turbine. The turbine drives the pump which transports the primary medium to the reactor core. The secondary medium enters the heat exchanger tubes and through their walls receives the heat from the primary medium. This design reduces capital costs of the reactor and increases its safety. (E.S.)

  18. Dehumanization: an integrative review.

    Science.gov (United States)

    Haslam, Nick

    2006-01-01

    The concept of dehumanization lacks a systematic theoretical basis, and research that addresses it has yet to be integrated. Manifestations and theories of dehumanization are reviewed, and a new model is developed. Two forms of dehumanization are proposed, involving the denial to others of 2 distinct senses of humanness: characteristics that are uniquely human and those that constitute human nature. Denying uniquely human attributes to others represents them as animal-like, and denying human nature to others represents them as objects or automata. Cognitive underpinnings of the "animalistic" and "mechanistic" forms of dehumanization are proposed. An expanded sense of dehumanization emerges, in which the phenomenon is not unitary, is not restricted to the intergroup context, and does not occur only under conditions of conflict or extreme negative evaluation. Instead, dehumanization becomes an everyday social phenomenon, rooted in ordinary social-cognitive processes.

  19. Integrated data base program

    International Nuclear Information System (INIS)

    Notz, K.J.

    1981-01-01

    The IDB Program provides direct support to the DOE Nuclear Waste Management and Fuel Cycle Programs and their lead sites and support contractors by providing and maintaining a current, integrated data base of spent fuel and radioactive waste inventories and projections. All major waste types (HLW, TRU, and LLW) and sources (government, commerical fuel cycle, and I/I) are included. A major data compilation was issued in September, 1981: Spent Fuel and Radioactive Waste Inventories and Projections as of December 31, 1980, DOE/NE-0017. This report includes chapters on Spent Fuel, HLW, TRU Waste, LLW, Remedial Action Waste, Active Uranium Mill Tailings, and Airborne Waste, plus Appendices with more detailed data in selected areas such as isotopics, radioactivity, thermal power, projections, and land usage. The LLW sections include volumes, radioactivity, thermal power, current inventories, projected inventories and characteristics, source terms, land requirements, and a breakdown in terms of government/commercial and defense/fuel cycle/I and I

  20. ALICE - ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva

    Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data...... management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. dCache provides support for several data management tools (among them for xrootd the tools used by AliEn) using the so called "doors". Therefore, we will concentrate on the second...... part. Solving it, was somewhat cumbersome, mainly due to the different computing models employed by AliEn and ARC. AliEN uses an Agent based pull model while ARC handles jobs through the more "traditional" push model. The solution comes as a module implementing the functionalities necessary to achieve...

  1. Wet storage integrity update

    International Nuclear Information System (INIS)

    Bailey, W.J.; Johnson, A.B. Jr.

    1983-09-01

    This report includes information from various studies performed under the Wet Storage Task of the Spent Fuel Integrity Project of the Commercial Spent Fuel Management (CSFM) Program at Pacific Northwest Laboratory. An overview of recent developments in the technology of wet storage of spent water reactor fuel is presented. Licensee Event Reports pertaining to spent fuel pools and the associated performance of spent fuel and storage components during wet storage are discussed. The current status of fuel that was examined under the CSFM Program is described. Assessments of the effect of boric acid in spent fuel pool water on the corrosion and stress corrosion cracking of stainless steel and the stress corrosion cracking of stainless steel piping containing stagnant water at spent fuel pools are discussed. A list of pertinent publications is included. 84 references, 21 figures, 11 tables

  2. Integrated astrophysical modeling

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, T. A.; Eastman, R. G.; Dubois, P.; Eltgroth, P. G.; Gentile, N.; Jedamzik, K.; Wilson, J. R.

    1997-06-03

    In this project, we have developed prototype techniques for defining and extending a variety of astrophysical modeling capabilities, including those involving multidimensional hydrodynamics, complex transport, and flexibly-coupled equation-of state and nuclear reaction networks. As expected, this project is having both near-term payoffs in understanding complex astrophysical phenomena, as well as significant spin-offs in terms of people and ideas to related ASCI code efforts. Most of our work in the first part of this project was focused on the modularization, extension, and initial integration of 4 previously separate and incommensurate codes: the stellar evolution/explosion code KEPLER; the non-LTE spectral line transport code, EDDINGTON, used for modeling supernovae spectra; the 3-D smooth particle hydro code, PIP; and the discontinuous-finite-element, 3D hydro module from the lCF3D code.

  3. Integrated Disability Management

    Directory of Open Access Journals (Sweden)

    Silvia Angeloni

    2013-10-01

    Full Text Available This article sets out to increase awareness regarding the wide and universal significance of disability, as well as the important benefits of an Integrated Disability Management (IDM approach. The scientific basis for IDM is explored in the first place through an analysis of its relationship to the International Classification of Functioning, Disability and Health (ICF. The conceptual paradigm of the ICF shares an ideological position with the IDM approach in that they are both underpinned by dynamic and multidimensional constructions of disability, which imply equally holistic and interdisciplinary responses. The IDM approach can be applied across a diversity of human situations to provide solutions that reflect the multifaceted and widespread nature of disability. The IDM approach is intended as a strategy capable of handling: inclusion of people with disabilities, active aging of human resources, health and safety in the workplace, prevention of disabilities and various diseases, return-to-work, absenteeism, and presenteeism.

  4. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas

    is applied to two single-family homes. In practice, such a scheme allowed most informational barriers to sustainable home renovation to be overcome. The homeowners were better integrated and their preferences and immaterial values were better taken into account. They assimilated the multiple benefits......Buildings are one of the largest end users of energy. In the countries of the European Union, the building sector accounts for nearly 40% of the final energy use and represents one of the largest potentials for the reduction of energy use and of greenhouse gas emissions. Furthermore, today....... In this thesis, examples of nearly zero energy single-family home renovations are presented. The most relevant existing decision support methods and tools applicable to sustainable renovation processes are reviewed and their applicability to high performance sustainable renovation is discussed. A qualitative...

  5. Integrated Environmental Assessment Modelling

    Energy Technology Data Exchange (ETDEWEB)

    Guardanz, R.; Gimeno, B. S.; Bermejo, V.; Elvira, S.; Martin, F.; Palacios, M.; Rodriguez, E.; Donaire, I. [Ciemat, Madrid (Spain)

    2000-07-01

    This report describes the results of the Spanish participation in the project Coupling CORINAIR data to cost-effect emission reduction strategies based on critical threshold. (EU/LIFE97/ENV/FIN/336). The subproject has focused on three tasks. Develop tools to improve knowledge on the spatial and temporal details of emissions of air pollutants in Spain. Exploit existing experimental information on plant response to air pollutants in temperate ecosystem and Integrate these findings in a modelling framework that can asses with more accuracy the impact of air pollutants to temperate ecosystems. The results obtained during the execution of this project have significantly improved the models of the impact of alternative emission control strategies on ecosystems and crops in the Iberian Peninsula. (Author) 375 refs.

  6. Integrated Usability Testing

    Directory of Open Access Journals (Sweden)

    Andrei Ternauciuc

    2015-11-01

    Full Text Available It is essential to regularly test the usability of a learning management system, in order to ensure a fast adoption by new users and rapidly shift the focus from the platform to the content and the learning experience. Quantitative testing yields the most reliable results due to the large number of data points acquired, but lacks the in-depth analysis of the qualitative research from a controlled testing setup. We are proposing in this paper an integrated usability testing tool, which can replace a certain type of laboratory testing, where the users’ actions on the real platform are measured and analyzed. We conducted tests with the tool and compared the results with a small scale laboratory test using the same scenarios. The results seem to confirm the proposed tool as a viable alternative to the laboratory test.

  7. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    they get more time for the cost optimization and the qualitative analysis of the users’ needs and behaviours. In order to reach a fossil free energy building stock within an acceptable time frame, it is primordial that researchers, politicians and the building industry work hand in hand. Indeed, in order...... to overcome the financial barriers to energy renovation and bring a new type of building experts in the building renovation sector, cost optimization tools for building renovation have been and can be developed but new legislation and politico-economic supports are still much needed. We present in this report...... a new contribution from the research and industry sides and results reached with the newly developed methodology, but without a significant contribution from the politico-economic and legislation sides . The experiences met during application of the Integrated Renovation Process are described...

  8. Desktop Computing Integration Project

    Science.gov (United States)

    Tureman, Robert L., Jr.

    1992-01-01

    The Desktop Computing Integration Project for the Human Resources Management Division (HRMD) of LaRC was designed to help division personnel use personal computing resources to perform job tasks. The three goals of the project were to involve HRMD personnel in desktop computing, link mainframe data to desktop capabilities, and to estimate training needs for the division. The project resulted in increased usage of personal computers by Awards specialists, an increased awareness of LaRC resources to help perform tasks, and personal computer output that was used in presentation of information to center personnel. In addition, the necessary skills for HRMD personal computer users were identified. The Awards Office was chosen for the project because of the consistency of their data requests and the desire of employees in that area to use the personal computer.

  9. Automatic numerical integration methods for Feynman integrals through 3-loop

    International Nuclear Information System (INIS)

    De Doncker, E; Olagbemi, O; Yuasa, F; Ishikawa, T; Kato, K

    2015-01-01

    We give numerical integration results for Feynman loop diagrams through 3-loop such as those covered by Laporta [1]. The methods are based on automatic adaptive integration, using iterated integration and extrapolation with programs from the QUADPACK package, or multivariate techniques from the ParInt package. The Dqags algorithm from QuadPack accommodates boundary singularities of fairly general types. PARINT is a package for multivariate integration layered over MPI (Message Passing Interface), which runs on clusters and incorporates advanced parallel/distributed techniques such as load balancing among processes that may be distributed over a network of nodes. Results are included for 3-loop self-energy diagrams without IR (infra-red) or UV (ultra-violet) singularities. A procedure based on iterated integration and extrapolation yields a novel method of numerical regularization for integrals with UV terms, and is applied to a set of 2-loop self-energy diagrams with UV singularities. (paper)

  10. Project Integration Architecture

    Science.gov (United States)

    Jones, William Henry

    2008-01-01

    The Project Integration Architecture (PIA) is a distributed, object-oriented, conceptual, software framework for the generation, organization, publication, integration, and consumption of all information involved in any complex technological process in a manner that is intelligible to both computers and humans. In the development of PIA, it was recognized that in order to provide a single computational environment in which all information associated with any given complex technological process could be viewed, reviewed, manipulated, and shared, it is necessary to formulate all the elements of such a process on the most fundamental level. In this formulation, any such element is regarded as being composed of any or all of three parts: input information, some transformation of that input information, and some useful output information. Another fundamental principle of PIA is the assumption that no consumer of information, whether human or computer, can be assumed to have any useful foreknowledge of an element presented to it. Consequently, a PIA-compliant computing system is required to be ready to respond to any questions, posed by the consumer, concerning the nature of the proffered element. In colloquial terms, a PIA-compliant system must be prepared to provide all the information needed to place the element in context. To satisfy this requirement, PIA extends the previously established object-oriented- programming concept of self-revelation and applies it on a grand scale. To enable pervasive use of self-revelation, PIA exploits another previously established object-oriented-programming concept - that of semantic infusion through class derivation. By means of self-revelation and semantic infusion through class derivation, a consumer of information can inquire about the contents of all information entities (e.g., databases and software) and can interact appropriately with those entities. Other key features of PIA are listed.

  11. Geological data integration techniques

    International Nuclear Information System (INIS)

    1988-09-01

    The objectives of this Technical Committee are to bring together current knowledge on geological data handling and analysis technologies as developed in the mineral and petroleum industries for geological, geophysical, geochemical and remote sensing data that can be applied to uranium exploration and resource appraisal. The recommendation for work on this topic was first made at the meeting of the NEA-IAEA Joint Group of Experts on R and D in Uranium Exploration Techniques (Paris, May 1984). In their report, processing of integrated data sets was considered to be extremely important in view of the very extensive data sets built up over the recent years by large uranium reconnaissance programmes. With the development of large, multidisciplinary data sets which includes geochemical, geophysical, geological and remote sensing data, the ability of the geologist to easily interpret large volumes of information has been largely the result of developments in the field of computer science in the past decade. Advances in data management systems, image processing software, the size and speed of computer systems and significantly reduced processing costs have made large data set integration and analysis practical and affordable. The combined signatures which can be obtained from the different types of data significantly enhance the geologists ability to interpret fundamental geological properties thereby improving the chances of finding a significant ore body. This volume is the product of one of a number of activities related to uranium geology and exploration during the past few years with the intent of bringing new technologies and exploration techniques to the IAEA Member States

  12. Integrative Radiation Biology

    Energy Technology Data Exchange (ETDEWEB)

    Barcellos-Hoff, Mary Helen [New York University School of Medicine, NY (United States)

    2015-02-27

    We plan to study tissue-level mechanisms important to human breast radiation carcinogenesis. We propose that the cell biology of irradiated tissues reveals a coordinated multicellular damage response program in which individual cell contributions are primarily directed towards suppression of carcinogenesis and reestablishment of homeostasis. We identified transforming growth factor β1 (TGFβ) as a pivotal signal. Notably, we have discovered that TGFβ suppresses genomic instability by controlling the intrinsic DNA damage response and centrosome integrity. However, TGFβ also mediates disruption of microenvironment interactions, which drive epithelial to mesenchymal transition in irradiated human mammary epithelial cells. This apparent paradox of positive and negative controls by TGFβ is the topic of the present proposal. First, we postulate that these phenotypes manifest differentially following fractionated or chronic exposures; second, that the interactions of multiple cell types in tissues modify the responses evident in this single cell type culture models. The goals are to: 1) study the effect of low dose rate and fractionated radiation exposure in combination with TGFβ on the irradiated phenotype and genomic instability of non-malignant human epithelial cells; and 2) determine whether stromal-epithelial interactions suppress the irradiated phenotype in cell culture and the humanized mammary mouse model. These data will be used to 3) develop a systems biology model that integrates radiation effects across multiple levels of tissue organization and time. Modeling multicellular radiation responses coordinated via extracellular signaling could have a significant impact on the extrapolation of human health risks from high dose to low dose/rate radiation exposure.

  13. Social Inclusion and Integrative Practices

    Directory of Open Access Journals (Sweden)

    David Cappo

    2014-06-01

    Full Text Available With the passage of time valuable lessons have been learnt about both effective practices for program and system integration and the sizable barriers, including the challenges in sustaining constructive integration. This paper is a reflection on sustainable integrative practices and is grounded in the direct experience of one of the authors, who held the post of the South Australian Social Inclusion Commissioner. We reflect upon the structure and mechanism of the South Australian Social Inclusion Initiative (2002–2011 as well as using a case study of a successful integrative program of the Social Inclusion Initiative, a program in South Australia’s School Retention Action Plan 2004 Making the Connections (South Australian Social Inclusion Board, 2004 that was implemented to improve school retention. The case study draws out salient factors of clear rationale, coordination, collaboration, communication, team work and trust as skills and ingredients to bring about integration in policy and programs. While the integration literature affirms that these ingredients are primary skills for the development of an integrative framework, we also assert that they are not enough for successful and sustained integration. Absent from much of the literature is a discussion about the use of power and the manner in which horizontal integrative work occurs. We take up this theme to draw out some implications for analysis of sustainable integrative practices.

  14. Abuse notation of improper integrals

    Science.gov (United States)

    Arfi, E.; Wiryanto, L. H.

    2018-01-01

    In the definition of \\int_ab {f(x)dx} , it was assumed that the interval [a, b] was finite. However, in many application in physics, engineering, economics, and probability we wish to allow a or b (or both) to be infinite or for the other case when f has an infinite discontinuity in [a, b]. In either case the integral is called improper integral. Definition of improper integral is the limit of a definite integral as an endpoint of the interval of integration approaches either a specified real number or ∞ or -∞ or, in some cases, as both endpoints approach limits. Many of the first-year students in ITERA learning about improper integrals make an abuse notation like written improper integral just like standard definite integral. Based on this situation, we tried to change the habits of the students in the writing of improper integrals by providing sufficient understanding and considerable exercises. It turns out this way gives good result, based on the percentage of the value of the midterms to the problem of improper integrals give a fairly good percentage value.

  15. Integrating cognitive (neuroscience using mechanisms

    Directory of Open Access Journals (Sweden)

    Marcin Miłkowski

    2016-11-01

    Full Text Available In this paper, an account of theoretical integration in cognitive (neuroscience from the mechanistic perspective is defended. It is argued that mechanistic patterns of integration can be better understood in terms of constraints on representations of mechanisms, not just on the space of possible mechanisms, as previous accounts of integration had it. This way, integration can be analyzed in more detail with the help of constraintsatisfaction account of coherence between scientific represen-tations. In particular, the account has resources to talk of idealizations and research heuristics employed by researchers to combine separate results and theoretical frameworks. The account is subsequently applied to an example of successful integration in the research on hippocampus and memory, and to a failure of integration in the research on mirror neurons as purportedly explanatory of sexual orientation.

  16. A digital long pulse integrator

    International Nuclear Information System (INIS)

    Broesch, J.D.; Strait, E.J.; Snider, R.T.

    1996-10-01

    A prototype digital integrator with very long integration capabilities has been developed and field tested on an inductive magnetic sensor on the DIII-D Tokamak. The integrator is being developed for use on ITER with a pulse length of 1000 s, and has direct applications for other long pulse Tokamaks. Inductive magnetic sensors are routinely used on existing Tokamaks, are well understood, and are extremely robust, however, they require integration of the signal to determine the magnetic field strength. The next generation of Tokamaks, will have pulse lengths of 1000 s or longer, require integrators with drift and noise characteristics compatible with the very long pulse lengths. This paper will discuss the architecture, algorithms, and programming of the Long Pulse Integrator (LPI). Of particular interest are the noise control and the built-in offset correction techniques used in this application

  17. Sourcing teams and interdepartmental integration

    DEFF Research Database (Denmark)

    Lidegaard, Nina; Ellegaard, Chris; Møller, Morten Munkgaard

    2015-01-01

    Internal integration is often mentioned as a prerequisite for conducting strategic sourcing, as multiple functional departments must collaborate on creating value-creating activities amongst them. Though it is one of many possibilities, the use of cross-functional teams is often the most commonly...... indicate that informal integration mechanisms not promoted by management or the organizational structure may contribute to the overall level of integration.......Internal integration is often mentioned as a prerequisite for conducting strategic sourcing, as multiple functional departments must collaborate on creating value-creating activities amongst them. Though it is one of many possibilities, the use of cross-functional teams is often the most commonly...... proposed solution to ensure internal integration. This paper presents an exploratory case study evaluating the use of internal integration mechanisms in a cross-functional sourcing process. Two commodity categories are examined. One is organised in a cross-functional team, while the other is not. Findings...

  18. Advanced Integrated Traction System

    Energy Technology Data Exchange (ETDEWEB)

    Greg Smith; Charles Gough

    2011-08-31

    The United States Department of Energy elaborates the compelling need for a commercialized competitively priced electric traction drive system to proliferate the acceptance of HEVs, PHEVs, and FCVs in the market. The desired end result is a technically and commercially verified integrated ETS (Electric Traction System) product design that can be manufactured and distributed through a broad network of competitive suppliers to all auto manufacturers. The objectives of this FCVT program are to develop advanced technologies for an integrated ETS capable of 55kW peak power for 18 seconds and 30kW of continuous power. Additionally, to accommodate a variety of automotive platforms the ETS design should be scalable to 120kW peak power for 18 seconds and 65kW of continuous power. The ETS (exclusive of the DC/DC Converter) is to cost no more than $660 (55kW at $12/kW) to produce in quantities of 100,000 units per year, should have a total weight less than 46kg, and have a volume less than 16 liters. The cost target for the optional Bi-Directional DC/DC Converter is $375. The goal is to achieve these targets with the use of engine coolant at a nominal temperature of 105C. The system efficiency should exceed 90% at 20% of rated torque over 10% to 100% of maximum speed. The nominal operating system voltage is to be 325V, with consideration for higher voltages. This project investigated a wide range of technologies, including ETS topologies, components, and interconnects. Each technology and its validity for automotive use were verified and then these technologies were integrated into a high temperature ETS design that would support a wide variety of applications (fuel cell, hybrids, electrics, and plug-ins). This ETS met all the DOE 2010 objectives of cost, weight, volume and efficiency, and the specific power and power density 2015 objectives. Additionally a bi-directional converter was developed that provides charging and electric power take-off which is the first step

  19. An architecture for integration of multidisciplinary models

    DEFF Research Database (Denmark)

    Belete, Getachew F.; Voinov, Alexey; Holst, Niels

    2014-01-01

    , Enterprise Application Integration, and Integration Design Patterns. We developed an architecture of a multidisciplinary model integration framework that brings these three aspects of integration together. Service-oriented-based platform independent architecture that enables to establish loosely coupled...

  20. Integrating Sustainability in Management Education

    OpenAIRE

    Emmanuel Raufflet

    2013-01-01

    Over the last decade, numerous modules, courses, and programs in Management Education have integrated sustainability into their curricula. However, this “integration” has translated into very diverse forms and contents. This article aims to clarify these ambiguities. It maps four forms of sustainability integration in Management Education. These four distinct forms are (1) discipline-based integration, in which the anchoring point is the business discipline (sustainability is added as a dimen...

  1. Path integral in Snyder space

    International Nuclear Information System (INIS)

    Mignemi, S.; Štrajn, R.

    2016-01-01

    The definition of path integrals in one- and two-dimensional Snyder space is discussed in detail both in the traditional setting and in the first-order formalism of Faddeev and Jackiw. - Highlights: • The definition of the path integral in Snyder space is discussed using phase space methods. • The same result is obtained in the first-order formalism of Faddeev and Jackiw. • The path integral formulation of the two-dimensional Snyder harmonic oscillator is outlined.

  2. Social inclusion and integrative practices

    OpenAIRE

    Cappo, David; Verity, Fiona

    2014-01-01

    With the passage of time valuable lessons have been learnt about both effective practices for program and system integration and the sizable barriers, including the challenges in sustaining constructive integration. This paper is a reflection on sustainable integrative practices and is grounded in the direct experience of one of the authors, who held the post of the South Australian Social Inclusion Commissioner. We reflect upon the structure and mechanism of the South Australian Social Inclu...

  3. Integrated systems innovations and applications

    CERN Document Server

    2015-01-01

    This book presents the results of discussions and presentation from the latest ISDT event (2014) which was dedicated to the 94th birthday anniversary of Prof. Lotfi A. Zade, father of Fuzzy logic. The book consists of three main chapters, namely: Chapter 1: Integrated Systems Design Chapter 2: Knowledge, Competence and Business Process Management Chapter 3: Integrated Systems Technologies Each article presents novel and scientific research results with respect to the target goal of improving our common understanding of KT integration.

  4. Path integral in Snyder space

    Energy Technology Data Exchange (ETDEWEB)

    Mignemi, S., E-mail: smignemi@unica.it [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy); Štrajn, R. [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy)

    2016-04-29

    The definition of path integrals in one- and two-dimensional Snyder space is discussed in detail both in the traditional setting and in the first-order formalism of Faddeev and Jackiw. - Highlights: • The definition of the path integral in Snyder space is discussed using phase space methods. • The same result is obtained in the first-order formalism of Faddeev and Jackiw. • The path integral formulation of the two-dimensional Snyder harmonic oscillator is outlined.

  5. Evolving Dimensions of Integral Education

    OpenAIRE

    Judie Gaffin Wexler

    2011-01-01

    This article explores the concept of integral education as a way to prepare students for the complex, rapidly changing global environment in which they will be living and working. It contends that education must help students focus both internally and externally if they are to be effectively prepared. The experience of the California Institute of Integral Studies is used as a case study to discuss key dimensions of integral education.

  6. Path integrals in curvilinear coordinates

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1984-01-01

    Integration limits are studied for presenting the path integral curvilinear coordinates. For spherical (and topoloqically equivalent) coordinates it is shown that in formulas involving classical action in the exponent integration over all variables should be carried out within infinite limits. Another peculiarity is associated with appearance of the operator q which provides a complete definition of the wave functions out of the physical region. arguments are given upporting the validity of the cited statament in the general case

  7. Integral comparison of library performance

    International Nuclear Information System (INIS)

    Mori, Takamasa

    2006-01-01

    The 2003-2004 activities of Reactor Integral Test WG under Subcommittee on Reactor Constants of Japanese Nuclear Data Committee are presented. During this period, the WG carried out integral tests of JENDL-3.3, ENDF/B-VI and JEF 2.2 (JEFF-3.0) for reactor applications. Some results of integral tests for other latest libraries, JEFF-3.1 and ENDF/B-VII are also presented. (author)

  8. Information Integration Technology Demonstration (IITD)

    National Research Council Canada - National Science Library

    Loe, Richard

    2001-01-01

    The objectives of the Information Integration Technology Demonstration (IITD) were to investigate, design a software architecture and demonstrate a capability to display intelligence data from multiple disciplines...

  9. The INTEGRAL Core Observing Programme

    DEFF Research Database (Denmark)

    Winkler, C.; Gehrels, N.; Lund, Niels

    1999-01-01

    The Core Programme of the INTEGRAL mission is defined as the portion of the scientific programme covering the guaranteed time observations for the INTEGRAL Science Working Team. This paper describes the current status of the Core Programme preparations and summarizes the key elements of the obser......The Core Programme of the INTEGRAL mission is defined as the portion of the scientific programme covering the guaranteed time observations for the INTEGRAL Science Working Team. This paper describes the current status of the Core Programme preparations and summarizes the key elements...

  10. Integrated Data Assimilation Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Data Assimilation Architecture (IDAA) addresses the fundamental problem of command, control, and communications systems interoperability....

  11. A primer of Lebesgue integration

    CERN Document Server

    Bear, H S

    2001-01-01

    The Lebesgue integral is now standard for both applications and advanced mathematics. This books starts with a review of the familiar calculus integral and then constructs the Lebesgue integral from the ground up using the same ideas. A Primer of Lebesgue Integration has been used successfully both in the classroom and for individual study.Bear presents a clear and simple introduction for those intent on further study in higher mathematics. Additionally, this book serves as a refresher providing new insight for those in the field. The author writes with an engaging, commonsense style that appeals to readers at all levels.

  12. Integrated Support Environment (ISE) Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose:The Integrated Support Environment (ISE) Laboratory serves the fleet, in-service engineers, logisticians and program management offices by automatically and...

  13. An integral part of an integrated preventive maintenance program

    International Nuclear Information System (INIS)

    Ferguson, B.J.

    1992-01-01

    This paper outlines the evolution of the Integrated Preventive Maintenance Program from the Reliability Centered Maintenance pilot program at Bruce Nuclear Generating Station (NGS) 'A.' The Integrated Preventive Maintenance Program provides the means for taking control of the Bruce NGS 'A' Preventive Maintenance Program. In addition, the development of the Bruce NGS 'A' Air-Operated Valve Preventive Maintenance is reviewed

  14. Coincidences of the concave integral and the pan-integral

    Czech Academy of Sciences Publication Activity Database

    Ouyang, Y.; Li, J.; Mesiar, Radko

    2017-01-01

    Roč. 9, č. 6 (2017), č. článku Article number 90. ISSN 2073-8994 Institutional support: RVO:67985556 Keywords : Concave integral * Monotone measure * Pan- integral * Subadditivity Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.457, year: 2016 http://library.utia.cas.cz/separaty/2017/E/mesiar-0477094.pdf

  15. Integration Becoming Business: Marketisation of Integration Training for Immigrants

    Science.gov (United States)

    Kurki, Tuuli; Masoud, Ameera; Niemi, Anna-Maija; Brunila, Kristiina

    2018-01-01

    Today, education is massively affected by marketisation and the drastic demands of the global economy. Integration training for immigrants has fallen prey to that; immigrants are employed to serve market needs, which has been attributed to the creation of "integration as business." In the article, the authors examine how integration…

  16. The effect of integrated reporting on integrated thinking between risk ...

    African Journals Online (AJOL)

    listed on the Johannesburg Stock Exchange (JSE) in South Africa, where integrated reporting is a listing .... environmental, social and governance considerations, into its investment analysis and activities. This should .... Integrated reporting has been criticised for a strong investor bias, with no attempt to open up substantive ...

  17. Digital integrated protection system

    International Nuclear Information System (INIS)

    Savornin, M.; Furet, M.

    1978-01-01

    As a result of technological progress it is now possible to achieve more elaborate protection functions able to follow more closely the phenomena to be supervised. For this reason the CEA, Framatome and Merlin/Gerin/CERCI have undertaken in commonn to develop a Digital Integrated Protection System (D.I.P.S.). This system is designed with the following aims: to improve the safety of the station, . to improve its availability, . to facilitate installation, . to facilitate tests and maintenance. The main characteristics adopted are: . possibilities of obtaining more elaborate monitoring and protection algorithm treatments, . order 4 redundancy of transducers, associated instruments and signal processing, . possibility of inhibiting part of the protection system, . standardisation of equipment, physical and electrical separation of redundant units, . use of multiplexed connections, . automation of tests. Four flow charts are presented: - DIPS with four APUP (Acquisition and Processing Unit for Protection) - APUP - LSU (Logic Safeguard Unit), number LSU corresponding to number fluidic safeguard circuits, - structure of a function unit, - main functions of the APUP [fr

  18. ATLAS Solenoid Integration

    CERN Multimedia

    Ruber, R

    Last month the central solenoid was installed in the barrel cryostat, which it shares with the liquid argon calorimeter. Some two years ago the central solenoid arrived at CERN after being manufactured and tested in Japan. It was kept in storage until last October when it was finally moved to the barrel cryostat integration area. Here a position survey of the solenoid (with respect to the cryostat's inner warm vessel) was performed. At the start of the New Year the solenoid was moved to the cryostat insertion stand. After a test insertion on 6th February and a few weeks of preparation work it was finally inserted on 27th February. A couple of hectic 24-hours/7-day weeks followed in order to connect all services in the cryostat bulkhead. But last Monday, 15th March, both warm flanges of the cryostat could be closed. In another week's time we expect to finish the connection of the cryogenic cooling lines and the superconducting bus lines with the external services. Then the cool-down and test will commence... ...

  19. Integrating EPICS and MDSplus

    International Nuclear Information System (INIS)

    Mastrovito, D.; Davis, W.; Dong, J.; Roney, P.; Sichta, P.

    2006-01-01

    The National Spherical Torus Experiment (NSTX) has been in operation at the Princeton Plasma Physics Laboratory (PPPL) since 1999. Since then, NSTX has made use of the Experimental Physics and Industrial Control System (EPICS) and MDSplus software packages, among others for control and data acquisition. To date, the two products have been integrated using special 'bridging' programs that include client-components for the EPICS and MDSplus servers. Recent improvements in the EPICS software have made it easier to develop a direct interface with MDSplus. This paper will describe the new EPICS extensions developed at PPPL that provide: (1) a direct data interface between EPICS process variables and MDSplus nodes; and (2) an interface between EPICS events and MDSplus events. These extensions have been developed for use with EPICS on Solaris and are currently being modified for use on real-time operating systems. Separately, an XML-RPC client was written to access EPICS 'trended' data, sampled usually once per minute during a 24 h period. The client extracts and writes a day's worth of trended data to a 'daily' MDSplus tree

  20. Integrated system checkout report

    International Nuclear Information System (INIS)

    1991-01-01

    The planning and preparation phase of the Integrated Systems Checkout Program (ISCP) was conducted from October 1989 to July 1991. A copy of the ISCP, DOE-WIPP 90--002, is included in this report as an appendix. The final phase of the Checkout was conducted from July 10, 1991, to July 23, 1991. This phase exercised all the procedures and equipment required to receive, emplace, and retrieve contact handled transuranium (CH TRU) waste filled dry bins. In addition, abnormal events were introduced to simulate various equipment failures, loose surface radioactive contamination events, and personnel injury. This report provides a detailed summary of each days activities during this period. Qualification of personnel to safely conduct the tasks identified in the procedures and the abnormal events were verified by observers familiar with the Bin-Scale CH TRU Waste Test requirements. These observers were members of the staffs of Westinghouse WID Engineering, QA, Training, Health Physics, Safety, and SNL. Observers representing a number of DOE departments, the state of new Mexico, and the Defense Nuclear Facilities Safety Board observed those Checkout activities conducted during the period from July 17, 1991, to July 23, 1991. Observer comments described in this report are those obtained from the staff member observers. 1 figs., 1 tab

  1. ALICE-ARC integration

    International Nuclear Information System (INIS)

    Anderlik, C; Gregersen, A R; Kleist, J; Peters, A; Saiz, P

    2008-01-01

    AliEn or Alice Environment is the Grid middleware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The inter-operation has two aspects, one is the data management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. Therefore, we will concentrate on the second part. Solving it, was somewhat cumbersome, mainly due to the different computing models employed by AliEn and ARC. AliEN uses an Agent based pull model while ARC handles jobs through the more 'traditional' push model. The solution comes as a module implementing the functionalities necessary to achieve AliEn job submission and management to ARC enabled sites

  2. Integrated methanol synthesis

    International Nuclear Information System (INIS)

    Jaeger, W.

    1982-01-01

    This invention concerns a plant for methanol manufacture from gasified coal, particularly using nuclear power. In order to reduce the cost of the hydrogen circuits, the methanol synthesis is integrated in the coal gasification plant. The coal used is gasified with hydration by means of hydrogen and the crude gas emerging, after cooling and separating the carbon dioxide and hydrogen sulphide, is mixed with the synthetic gas leaving the methane cracking furnace. This mixture is taken to the methanol synthesis and more than 90% is converted into methanol in one pass. The gas mixture remaning after condensation and separation of methanol is decomposed into three fractions in low temperature gas decomposition with a high proportion of unconverted carbon monoxide. The flow of methane is taken to the cracking furnace with steam, the flow of hydrogen is taken to the hydrating coal gasifier, and the flow of carbon monoxide is taken to the methanol synthesis. The heat required for cracking the methane can either be provided by a nuclear reactor or by the coke left after hydrating gasification. (orig./RB) [de

  3. ALICE: ARC integration

    CERN Document Server

    Anderlik, C; Kleist, J; Peters, A; Saiz, P

    2008-01-01

    AliEn or Alice Environment is the Grid middleware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The inter-operation has two aspects, one is the data management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. Therefore, we will concentrate on the second part. Solving it, was somewhat cumbersome, mainly due to the different computing models employed by AliEn and ARC. AliEN uses an Agent based pull model while ARC handles jobs through the more 'traditional' push model. The solution comes as a modu...

  4. Integrated optic waveguide devices

    Science.gov (United States)

    Ramer, O. G.

    1980-01-01

    Integrated optic waveguide circuits with a phase bias and modulator on the same chip were designed, fabricated, and tested for use in a fiber-optic rotation sensor (gyro) under development. Single mode fiber-optic pigtails were permanently coupled to the four ports of the chip. The switch format was based on coherent coupling between waveguides formed in Z-cut LiNbO3. The control of the coupling was achieved by electro-optically varying the phase propagation constants of each guide. Fiber-to-chip interfacing required the development of appropriate fixturing and manipulation techniques to achieve the close tolerance needed for high coupling efficiency between a fiber with an approximately 5 micron m core and a channel guide with a roughly 2 micron m by 5 micron m cross section. Switch and chip performance at 0.85 micron m is discussed as well as potential improvements related to insertion loss reduction, switching voltages, and suppression of Li2O out-diffusion.

  5. Integrated Urban Nutrient Management

    Science.gov (United States)

    Nhapi, I.; Veenstra, S.; Siebel, M. A.; Gijzen, H. J.

    Most cities, especially from the developing countries, are facing serious problems with the management of nutrients, necessitating an urgent review of current waste management systems. Whilst highly efficient technologies are available, the inclusion of these in a well-thought out and systematic approach is necessary to contain the nutrient influxes and outfluxes from towns. Five intervention measures are proposed in this paper. The first is to manage the use and generation of nutrients by drastically minimising water consumption and employing other cleaner production approaches. The second deals with the optimal reuse of nutrients and water at the smallest possible level, like at the household and on-plot level. The second option is to covert the waste into something useful for reuse, and, where not possible, to something which is envi- ronmentally neutral. This involves treatment, but applying technologies that makes the best use of side products via reuse. Where the first three options will have failed, two least preferred options could be used. Waste can be dispersed or diluted to enhance self-purification capacities of downstream water bodies. The last option is to store the wastewater for some parts of the year when there is water shortage to allow for polishing during the standing period. The success of urban nutrient planning requires an integrated approach, proving specific solutions to specific situations. This, in turn, requires appropriate institutional responses.

  6. ALICE—ARC integration

    Science.gov (United States)

    Anderlik, C.; Gregersen, A. R.; Kleist, J.; Peters, A.; Saiz, P.

    2008-07-01

    AliEn or Alice Environment is the Grid middleware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The inter-operation has two aspects, one is the data management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. Therefore, we will concentrate on the second part. Solving it, was somewhat cumbersome, mainly due to the different computing models employed by AliEn and ARC. AliEN uses an Agent based pull model while ARC handles jobs through the more 'traditional' push model. The solution comes as a module implementing the functionalities necessary to achieve AliEn job submission and management to ARC enabled sites.

  7. Integrated system checkout report

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-14

    The planning and preparation phase of the Integrated Systems Checkout Program (ISCP) was conducted from October 1989 to July 1991. A copy of the ISCP, DOE-WIPP 90--002, is included in this report as an appendix. The final phase of the Checkout was conducted from July 10, 1991, to July 23, 1991. This phase exercised all the procedures and equipment required to receive, emplace, and retrieve contact handled transuranium (CH TRU) waste filled dry bins. In addition, abnormal events were introduced to simulate various equipment failures, loose surface radioactive contamination events, and personnel injury. This report provides a detailed summary of each days activities during this period. Qualification of personnel to safely conduct the tasks identified in the procedures and the abnormal events were verified by observers familiar with the Bin-Scale CH TRU Waste Test requirements. These observers were members of the staffs of Westinghouse WID Engineering, QA, Training, Health Physics, Safety, and SNL. Observers representing a number of DOE departments, the state of new Mexico, and the Defense Nuclear Facilities Safety Board observed those Checkout activities conducted during the period from July 17, 1991, to July 23, 1991. Observer comments described in this report are those obtained from the staff member observers. 1 figs., 1 tab.

  8. Integrated groundwater data management

    Science.gov (United States)

    Fitch, Peter; Brodaric, Boyan; Stenson, Matt; Booth, Nathaniel; Jakeman, Anthony J.; Barreteau, Olivier; Hunt, Randall J.; Rinaudo, Jean-Daniel; Ross, Andrew

    2016-01-01

    The goal of a data manager is to ensure that data is safely stored, adequately described, discoverable and easily accessible. However, to keep pace with the evolution of groundwater studies in the last decade, the associated data and data management requirements have changed significantly. In particular, there is a growing recognition that management questions cannot be adequately answered by single discipline studies. This has led a push towards the paradigm of integrated modeling, where diverse parts of the hydrological cycle and its human connections are included. This chapter describes groundwater data management practices, and reviews the current state of the art with enterprise groundwater database management systems. It also includes discussion on commonly used data management models, detailing typical data management lifecycles. We discuss the growing use of web services and open standards such as GWML and WaterML2.0 to exchange groundwater information and knowledge, and the need for national data networks. We also discuss cross-jurisdictional interoperability issues, based on our experience sharing groundwater data across the US/Canadian border. Lastly, we present some future trends relating to groundwater data management.

  9. Integral risk assessment

    International Nuclear Information System (INIS)

    Chakraborty, S.; Yadigaroglu, G.

    1991-01-01

    The series of lectures which forms the basis of this book and took place in the winter of 1989/90 at the ETH in Zuerich were held for the purpose of discussing the stage of development of our system of ethics in view of the extremely fast pace of technological progress and the risks which accompany it. Legal, psychological and political aspects of the problem were examined, but the emphasis was placed on ethical aspects. The effects which are examined in conventional risk analyses can be considered as a part of the ethical and social aspects involved, and in turn, the consideration of ethical and social aspects can be viewed as an extension of the conventional form of risk analysis. In any case, among risk experts, the significance of ethical and social factors is uncontested, especially as regards activities which can have far-reaching repurcussions. Some objective difficulties interfere with this goal, however: - No generally acknowledged set of ethical values exists. - Cultural influences and personal motives can interfere. - Normally a risk assessment is carried out in reference to individual facilities and within a small, clearly defined framework. Under certain circumstances, generalizations which are made for complete technological systems can lead to completely different conclusions. One contribution deals with integral views of the risks of atomic energy from an ethical and social perspective. (orig.) [de

  10. Integrated sensor bus

    Science.gov (United States)

    Rutka, M. J.

    1994-03-01

    In this thesis an integrated sensor bus interface is presented. The proposed bus offers a number of interface procedures to enhance the system flexibility. It enables a 13-bit data exchange per message frame, automatic addressing, device clearing and resetting, and handling of service-request and polling procedures. Chapter 1 provides an overview of the existing data transmission technologies. It presents the most popular digital buses along with their application fields. Also other research activities on sensor buses are described. Chapter 2 deals with the requirements which have to be imposed on the desired sensor bus. It shows both communication and compatibility requirements. Chapter 3 introduces the proposed sensor bus. It presents the interface structure together with implemented bus procedures. The detailed description of the proposed sensor bus protocol is given in Chapter 4. It is divided into two parts; a logical layer description (i.e., sensor bus protocol) and a physical layer description (i.e., transmission medium and electrical characteristics). Chapter 5 deals with the compatibility issue. It investigates differences between typical processes used for sensors and digital circuits. Chapter 6 shows the design of a sensor bus interface prototype. In Chapter 7 the performance of the fabricated interface is discussed.

  11. Integral geometry and holography

    Energy Technology Data Exchange (ETDEWEB)

    Czech, Bartłomiej; Lamprou, Lampros; McCandlish, Samuel [Stanford Institute for Theoretical Physics, Department of Physics, Stanford University,Stanford, CA 94305 (United States); Sully, James [Theory Group, SLAC National Accelerator Laboratory,Menlo Park, CA 94025 (United States)

    2015-10-27

    We present a mathematical framework which underlies the connection between information theory and the bulk spacetime in the AdS{sub 3}/CFT{sub 2} correspondence. A key concept is kinematic space: an auxiliary Lorentzian geometry whose metric is defined in terms of conditional mutual informations and which organizes the entanglement pattern of a CFT state. When the field theory has a holographic dual obeying the Ryu-Takayanagi proposal, kinematic space has a direct geometric meaning: it is the space of bulk geodesics studied in integral geometry. Lengths of bulk curves are computed by kinematic volumes, giving a precise entropic interpretation of the length of any bulk curve. We explain how basic geometric concepts — points, distances and angles — are reflected in kinematic space, allowing one to reconstruct a large class of spatial bulk geometries from boundary entanglement entropies. In this way, kinematic space translates between information theoretic and geometric descriptions of a CFT state. As an example, we discuss in detail the static slice of AdS{sub 3} whose kinematic space is two-dimensional de Sitter space.

  12. Integrated fuel processor development

    International Nuclear Information System (INIS)

    Ahmed, S.; Pereira, C.; Lee, S. H. D.; Krumpelt, M.

    2001-01-01

    The Department of Energy's Office of Advanced Automotive Technologies has been supporting the development of fuel-flexible fuel processors at Argonne National Laboratory. These fuel processors will enable fuel cell vehicles to operate on fuels available through the existing infrastructure. The constraints of on-board space and weight require that these fuel processors be designed to be compact and lightweight, while meeting the performance targets for efficiency and gas quality needed for the fuel cell. This paper discusses the performance of a prototype fuel processor that has been designed and fabricated to operate with liquid fuels, such as gasoline, ethanol, methanol, etc. Rated for a capacity of 10 kWe (one-fifth of that needed for a car), the prototype fuel processor integrates the unit operations (vaporization, heat exchange, etc.) and processes (reforming, water-gas shift, preferential oxidation reactions, etc.) necessary to produce the hydrogen-rich gas (reformate) that will fuel the polymer electrolyte fuel cell stacks. The fuel processor work is being complemented by analytical and fundamental research. With the ultimate objective of meeting on-board fuel processor goals, these studies include: modeling fuel cell systems to identify design and operating features; evaluating alternative fuel processing options; and developing appropriate catalysts and materials. Issues and outstanding challenges that need to be overcome in order to develop practical, on-board devices are discussed

  13. ATLAS Solenoid Integration

    CERN Multimedia

    Ruber, R

    Last month the central solenoid was installed in the barrel cryostat, which it shares with the liquid argon calorimeter. Figure 1: Some members of the solenoid and liquid argon teams proudly pose in front of the barrel cryosat, complete with detector and magnet. Some two years ago the central solenoid arrived at CERN after being manufactured and tested in Japan. It was kept in storage until last October when it was finally moved to the barrel cryostat integration area. Here a position survey of the solenoid (with respect to the cryostat's inner warm vessel) was performed. Figure 2: The alignment survey by Dirk Mergelkuhl and Aude Wiart. (EST-SU) At the start of the New Year the solenoid was moved to the cryostat insertion stand. Figure 3: The solenoid on the insertion stand, with Akira Yamamoto the solenoid designer and project leader. Figure 4: Taka Kondo, ATLAS Japan spokesperson, and Shoichi Mizumaki, Toshiba project engineer for the ATLAS solenoid, celebrate the insertion. Aft...

  14. Integrating capital budgeting techniques.

    Science.gov (United States)

    Rogers, M M; Rothe, K

    1993-02-01

    A.J. Hogan, in "Capital Expenditure Planning: The Value of Information to Hospitals," published in 1987 in Hospital and Health Services Administration, illustrated the value of information to the expenditure process. He noted that knowing what your competitors are up to, as well as where your facility stands in the market, can enable all concerned to make better judgments. One of the likely outcomes of good judgments is the efficient use of all resources. Unfortunately, Hogan's model draws on a non-existent computerized regional planning agency with the authority to approve or deny proposals. Integrated strategic financial planning also illustrates the value of information. In this case, information is readily available. The sources are the administrators: finance, accounting, marketing, and planning experts, doctors, nurses, statisticians, and epidemiologists. Each can make a unique contribution to the process, and together they can effectively guide the organization's capital budgeting programs. We have illustrated that there does exist a planning model that can work with the plurality of viewpoints in today's hospitals to produce the "most informed" decisions with known sensitivity to the decision criteria used.

  15. Integrative radiation systems biology

    International Nuclear Information System (INIS)

    Unger, Kristian

    2014-01-01

    Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer” of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology

  16. Body integrity identity disorder.

    Directory of Open Access Journals (Sweden)

    Rianne M Blom

    Full Text Available INTRODUCTION: Body Integrity Identity Disorder (BIID is a rare, infrequently studied and highly secretive condition in which there is a mismatch between the mental body image and the physical body. Subjects suffering from BIID have an intense desire to amputate a major limb or severe the spinal cord in order to become paralyzed. Aim of the study is to broaden the knowledge of BIID amongst medical professionals, by describing all who deal with BIID. METHODS: Somatic, psychiatric and BIID characteristic data were collected from 54 BIID individuals using a detailed questionnaire. Subsequently, data of different subtypes of BIID (i.e. wish for amputation or paralyzation were evaluated. Finally, disruption in work, social and family life due to BIID in subjects with and without amputation were compared. RESULTS: Based on the subjects' reports we found that BIID has an onset in early childhood. The main rationale given for their desire for body modification is to feel complete or to feel satisfied inside. Somatic and severe psychiatric co-morbidity is unusual, but depressive symptoms and mood disorders can be present, possibly secondary to the enormous distress BIID puts upon a person. Amputation and paralyzation variant do not differ in any clinical variable. Surgery is found helpful in all subjects who underwent amputation and those subjects score significantly lower on a disability scale than BIID subjects without body modification. CONCLUSIONS: The amputation variant and paralyzation variant of BIID are to be considered as one of the same condition. Amputation of the healthy body part appears to result in remission of BIID and an impressive improvement of quality of life. Knowledge of and respect for the desires of BIID individuals are the first steps in providing care and may decrease the huge burden they experience.

  17. Body integrity identity disorder.

    Science.gov (United States)

    Blom, Rianne M; Hennekam, Raoul C; Denys, Damiaan

    2012-01-01

    Body Integrity Identity Disorder (BIID) is a rare, infrequently studied and highly secretive condition in which there is a mismatch between the mental body image and the physical body. Subjects suffering from BIID have an intense desire to amputate a major limb or severe the spinal cord in order to become paralyzed. Aim of the study is to broaden the knowledge of BIID amongst medical professionals, by describing all who deal with BIID. Somatic, psychiatric and BIID characteristic data were collected from 54 BIID individuals using a detailed questionnaire. Subsequently, data of different subtypes of BIID (i.e. wish for amputation or paralyzation) were evaluated. Finally, disruption in work, social and family life due to BIID in subjects with and without amputation were compared. Based on the subjects' reports we found that BIID has an onset in early childhood. The main rationale given for their desire for body modification is to feel complete or to feel satisfied inside. Somatic and severe psychiatric co-morbidity is unusual, but depressive symptoms and mood disorders can be present, possibly secondary to the enormous distress BIID puts upon a person. Amputation and paralyzation variant do not differ in any clinical variable. Surgery is found helpful in all subjects who underwent amputation and those subjects score significantly lower on a disability scale than BIID subjects without body modification. The amputation variant and paralyzation variant of BIID are to be considered as one of the same condition. Amputation of the healthy body part appears to result in remission of BIID and an impressive improvement of quality of life. Knowledge of and respect for the desires of BIID individuals are the first steps in providing care and may decrease the huge burden they experience.

  18. Radon integral measurement system

    International Nuclear Information System (INIS)

    Garcia H, J.M.

    1994-01-01

    The Radon Integral Measurement System (SMIR) is a device designed specially to detect, to count and to store the data of the acquisition of alpha particles emitted by Radon-222 coming from the underground. The system includes a detection chamber, a radiation detector, a digital system with bateries backup and an auxiliary photovoltaic cell. A personal computer fixes the mode in which the system works, transmitting the commands to the system by the serial port. The heart of the system is a microprocesor working with interrupts by hardware. Every external device to the microprocessor sends his own interrupt request and the microprocessor handles the interrupts with a defined priority. The system uses a real time clock, compatible with the microprocessor, to take care of the real timing and date of the acquisition. A non volatile RAM is used to store data of two bytes every 15 minutes along 41 days as a maximum. After the setting up to the system by the computer, it can operate in stand alone way for up 41 days in the working place without the lose of any data. If the memory is full the next data will be written in the first locations of the memory. The memory is divided in pages corresponding every one of this to a different day of the acquisition. The counting time for every acquisition can be programmed by the user from 15 minutes to 65535 minutes but it is recommended to use a small time not to reach the limit of 65535 counts in every acquisition period. We can take information of the system without affecting the acquisition process in the field by using a lap top computer, then the information can be stored in a file. There is a program in the computer that can show the information in a table of values or in a bar graph. (Author)

  19. Integrated electrochromic aperture diaphragm

    Science.gov (United States)

    Deutschmann, T.; Oesterschulze, E.

    2014-05-01

    In the last years, the triumphal march of handheld electronics with integrated cameras has opened amazing fields for small high performing optical systems. For this purpose miniaturized iris apertures are of practical importance because they are essential to control both the dynamic range of the imaging system and the depth of focus. Therefore, we invented a micro optical iris based on an electrochromic (EC) material. This material changes its absorption in response to an applied voltage. A coaxial arrangement of annular rings of the EC material is used to establish an iris aperture without need of any mechanical moving parts. The advantages of this device do not only arise from the space-saving design with a thickness of the device layer of 50μm. But it also benefits from low power consumption. In fact, its transmission state is stable in an open circuit, phrased memory effect. Only changes of the absorption require a voltage of up to 2 V. In contrast to mechanical iris apertures the absorption may be controlled on an analog scale offering the opportunity for apodization. These properties make our device the ideal candidate for battery powered and space-saving systems. We present optical measurements concerning control of the transmitted intensity and depth of focus, and studies dealing with switching times, light scattering, and stability. While the EC polymer used in this study still has limitations concerning color and contrast, the presented device features all functions of an iris aperture. In contrast to conventional devices it offers some special features. Owing to the variable chemistry of the EC material, its spectral response may be adjusted to certain applications like color filtering in different spectral regimes (UV, optical range, infrared). Furthermore, all segments may be switched individually to establish functions like spatial Fourier filtering or lateral tunable intensity filters.

  20. Integrating Concepts in Biology

    Science.gov (United States)

    Luckie, Douglas B; Hoskinson, Anne-Marie; Griffin, Caleigh E; Hess, Andrea L; Price, Katrina J; Tawa, Alex; Thacker, Samantha M

    2017-01-01

    The purpose of this study was to examine the educational impact of an intervention, the inquiry-focused textbook Integrating Concepts in Biology ( ICB ), when used in a yearlong introductory biology course sequence. Student learning was evaluated using three published instruments: 1) The Biology Concept Inventory probed depth of student mastery of fundamental concepts in organismal and cellular topics when confronting misconceptions as distractors. ICB students had higher gains in all six topic categories (+43% vs. peers overall, p concepts, like experts. The frequency with which ICB students connected deep-concept pairs, or triplets, was similar to peers; but deep understanding of structure/function was much higher (for pairs: 77% vs. 25%, p < 0.01). 3) A content-focused Medical College Admission Test (MCAT) posttest compared ICB student content knowledge with that of peers from 15 prior years. Historically, MCAT performance for each semester ranged from 53% to 64%; the ICB cohort scored 62%, in the top quintile. Longitudinal tracking in five upper-level science courses the following year found ICB students outperformed peers in physiology (85% vs. 80%, p < 0.01). © 2017 D. B. Luckie et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  1. Material integrity verification radar

    International Nuclear Information System (INIS)

    Koppenjan, S.K.

    1999-01-01

    The International Atomic Energy Agency (IAEA) has the need for verification of 'as-built' spent fuel-dry storage containers and other concrete structures. The IAEA has tasked the Special Technologies Laboratory (STL) to fabricate, test, and deploy a stepped-frequency Material Integrity Verification Radar (MIVR) system to nondestructively verify the internal construction of these containers. The MIVR system is based on previously deployed high-frequency, ground penetrating radar (GPR) systems that have been developed by STL for the U.S. Department of Energy (DOE). Whereas GPR technology utilizes microwave radio frequency energy to create subsurface images, MTVR is a variation for which the medium is concrete instead of soil. The purpose is to nondestructively verify the placement of concrete-reinforcing materials, pipes, inner liners, and other attributes of the internal construction. The MIVR system underwent an initial field test on CANDU reactor spent fuel storage canisters at Atomic Energy of Canada Limited (AECL), Chalk River Laboratories, Ontario, Canada, in October 1995. A second field test at the Embalse Nuclear Power Plant in Embalse, Argentina, was completed in May 1996. The DOE GPR also was demonstrated at the site. Data collection and analysis were performed for the Argentine National Board of Nuclear Regulation (ENREN). IAEA and the Brazilian-Argentine Agency for the Control and Accounting of Nuclear Material (ABACC) personnel were present as observers during the test. Reinforcing materials were evident in the color, two-dimensional images produced by the MIVR system. A continuous pattern of reinforcing bars was evident and accurate estimates on the spacing, depth, and size were made. The potential uses for safeguard applications were jointly discussed. The MIVR system, as successfully demonstrated in the two field tests, can be used as a design verification tool for IAEA safeguards. A deployment of MIVR for Design Information Questionnaire (DIQ

  2. Balanced Integrated Regulatory Oversight

    International Nuclear Information System (INIS)

    Borchardt, R.W.

    2010-01-01

    Reactor safety, protecting the public health and safety, and protecting the environment must always be the nuclear regulator's top priorities. Enabling the use of nuclear power for the benefit of society, while protecting the public and the environment requires the regulator to balance many factors. In addition, the regulator is only one part of the overall government that must consider many factors as it carries out its societal responsibilities. Some of the factors that must be balanced and the practical impacts on how the regulator carries out its responsibilities will be addressed. The first International Conference on Effective Regulatory Systems, held in Moscow, Russian Federation, in 2006, focused on safety and security challenges with a goal of improving regulatory effectiveness through cooperation and sharing of information and best practices. The challenge of meeting both safety and security objectives is one example of potentially competing programmes that must be balanced. Other balances that must be evaluated include the benefits of safety improvements compared to the cost of implementation, the use of deterministic and probabilistic approaches, communication openness balanced with the protection of information that could be used for detrimental purposes, and timeliness of regulatory decision making balanced with the need to perform quality work in support of oversight responsibilities. A balanced and integrated approach to regulatory oversight is vital to ensuring that the regulatory body remains effective in its mission to enable the use of nuclear power while protecting the public and the environment. This concept is applicable to nations beginning a nuclear programme as well as established and experienced regulatory bodies. (author)

  3. Perceptual integration without conscious access

    NARCIS (Netherlands)

    Fahrenfort, Johannes J.; Van Leeuwen, Jonathan; Olivers, Christian N.L.; Hogendoorn, Hinze

    2017-01-01

    The visual system has the remarkable ability to integrate fragmentary visual input into a perceptually organized collection of surfaces and objects, a process we refer to as perceptual integration. Despite a long tradition of perception research, it is not known whether access to consciousness is

  4. Integrative holistic medicine in Minnesota.

    Science.gov (United States)

    Torkelson, Carolyn J; Manahan, Bill

    2009-05-01

    Minnesota has played a leading role in the integrative holistic medicine movement in the United States for more than 2 decades. This article defines integrative holistic medicine and describes how it is practiced. It also discusses the reasons why institutions and providers here and elsewhere in the country have embraced this approach to patient care.

  5. Teacher Beliefs and Technology Integration

    Science.gov (United States)

    Kim, ChanMin; Kim, Min Kyu; Lee, Chiajung; Spector, J. Michael; DeMeester, Karen

    2013-01-01

    The purpose of this exploratory mixed methods study was to investigate how teacher beliefs were related to technology integration practices. We were interested in how and to what extent teachers' (a) beliefs about the nature of knowledge and learning, (b) beliefs about effective ways of teaching, and (c) technology integration practices were…

  6. Technology Integration Experiences of Teachers

    Science.gov (United States)

    Çoklar, Ahmet Naci; Yurdakul, Isil Kabakçi

    2017-01-01

    Teachers are important providers of educational sustainability. Teachers' ability to adapt themselves to rapidly developing technologies applicable to learning environments is connected with technology integration. The purpose of this study is to investigate teachers' technology integration experiences in the course of learning and teaching…

  7. Integrity Constraints in Trust Management

    NARCIS (Netherlands)

    Etalle, Sandro; Winsborough, William H.

    We introduce the use, monitoring, and enforcement of integrity constraints in trust managementstyle authorization systems. We consider what portions of the policy state must be monitored to detect violations of integrity constraints. Then we address the fact that not all participants in a trust

  8. Family migration and migrant integration

    NARCIS (Netherlands)

    Bonjour, S.; Kraler, A.; Triandafyllidou, A.

    2016-01-01

    Family migration and integration are intimately related concepts in contemporary policy discourses in major migrant receiving countries. In these discourses, both family related migration as such and the migrant family as an institution are problematised with regard to their relation to integration.

  9. National Integration, Citizenship, Political Participation

    African Journals Online (AJOL)

    USER

    examines the issues, problems and contexts of national integration or the national question in Nigeria. It also discusses the .... In other words, a sense. National Integration, Citizenship, Political Participation & Democratic Stability in Nigeria .... unorganized, episodic or continuous, employing legitimate or illegitimate methods ...

  10. Continual integral in perturbation theory

    International Nuclear Information System (INIS)

    Slavnov, A.A.

    1975-01-01

    It is shown that all results obtained by means of continual integration within the framework of perturbation theory are completely equivalent to those obtained by the usual diagram technique and are therfore just as rigorous. A rigorous justification is given for the rules for operating with continual integrals in perturbation theory. (author)

  11. Regrouping for an Integrated Curriculum

    Science.gov (United States)

    Murdock, Jane E.

    1978-01-01

    A new integrated nursing curriculum at the University of Connecticut School of Nursing, representative of a change from a traditional to an integrated nursing program, required teachers to become generalists in nursing theory and practice. The author describes the new curriculum framework, redefined faculty teams, and clinical experience. (MF)

  12. Designing the Knowledge Integration Environment.

    Science.gov (United States)

    Linn, Marcia C.

    2000-01-01

    Explains Knowledge Integration Environment (KIE) activities which are designed to promote lifelong science learning. Describes the partnership process that guided the design as well as the Scaffolded Knowledge Integration (SKI) framework that gave the partnership a head start on creating effective materials. (Contains 52 references.) (Author/YDS)

  13. Integrative approaches: promoting socioecological resilience

    Science.gov (United States)

    J.W. Long; Carl Skinner; M. North; C.T. Hunsaker; L. Quinn-Davidson

    2014-01-01

    This chapter begins by discussing current challenges for ecosystem management that emerged from multiple chapters of the full synthesis. It then considers integrative approaches to promote resilience, including general strategies that recognize the integrated nature of socioecological systems, the importance of promoting disturbance regimes upon which these systems...

  14. A Romberg Integral Spreadsheet Calculator

    Directory of Open Access Journals (Sweden)

    Kim Gaik Tay

    2015-04-01

    Full Text Available Motivated by the work of Richardson’s extrapolation spreadsheet calculator up to level 4 to approximate definite differentiation, we have developed a Romberg integral spreadsheet calculator to approximate definite integral. The main feature of this version of spreadsheet calculator is a friendly graphical user interface developed to capture the needed information to solve the integral by Romberg method. Users simply need to enter the variable in the integral, function to be integrated, lower and upper limits of the integral, select the desired accuracy of computation, select the exact function if it exists and lastly click the Compute button which is associated with VBA programming written to compute Romberg integral table. The full solution of the Romberg integral table up to any level can be obtained quickly and easily using this method. The attached spreadsheet calculator together with this paper helps educators to prepare their marking scheme easily and assist students in checking their answers instead of reconstructing the answers from scratch. A summative evaluation of this Romberg Spreadsheet Calculator has been conducted by involving 36 students as sample. The data was collected using questionnaire. The findings showed that the majority of the students agreed that the Romberg Spreadsheet Calculator provides a structured learning environment that allows learners to be guided through a step-by-step solution.

  15. Essays on financial market integration

    NARCIS (Netherlands)

    Pungulescu, C.

    2009-01-01

    The four essays in this dissertation address these main questions and alternate a general perspective with focused analysis on specific measures of integration and regions, providing several novel answers. First, new relevant proxies are proposed to measure financial market integration. They give

  16. Integrated Wind Power Planning Tool

    DEFF Research Database (Denmark)

    Rosgaard, Martin H.; Hahmann, Andrea N.; Nielsen, Torben S.

    This poster presents the Public Service Obligation (PSO) funded project PSO 10464 "Integrated Wind Power Planning Tool". The project goal is to integrate a Numerical Weather Prediction (NWP) model with statistical tools in order to assess wind power fluctuations, with focus on short term...... forecasting for existing wind farms, as well as long term power system planning for future wind farms....

  17. Snakes: An Integrated Unit Plan.

    Science.gov (United States)

    Lawrence, Lisa

    This document presents an integrated unit plan on snakes targeting second grade students. Objectives of the unit include developing concepts of living things, understanding the contribution and importance of snakes to the environment, and making connections between different disciplines. The unit integrates the topic of snakes into the areas of…

  18. Probability inequalities for decomposition integrals

    Czech Academy of Sciences Publication Activity Database

    Agahi, H.; Mesiar, Radko

    2017-01-01

    Roč. 315, č. 1 (2017), s. 240-248 ISSN 0377-0427 Institutional support: RVO:67985556 Keywords : Decomposition integral * Superdecomposition integral * Probability inequalities Subject RIV: BA - General Mathematics OBOR OECD: Statistics and probability Impact factor: 1.357, year: 2016 http://library.utia.cas.cz/separaty/2017/E/mesiar-0470959.pdf

  19. Angular integrals in d dimensions

    International Nuclear Information System (INIS)

    Somogyi, Gabor

    2011-01-01

    We discuss the evaluation of certain d dimensional angular integrals which arise in perturbative field theory calculations. We find that the angular integral with n denominators can be computed in terms of a certain special function, the so-called H-function of several variables. We also present several illustrative examples of the general result and briefly consider some applications. (orig.)

  20. Probabilistic XML in Information Integration

    NARCIS (Netherlands)

    de Keijzer, Ander; Shim, J.; Casati, F.

    2006-01-01

    Information integration is a difficult research problem. In an ambient environment, where devices can connect and disconnect arbitrarily, the problem only increases, because data sources may become available at any time, but can also disappear. In such an environment, information integration needs

  1. A Single-Pulse Integrator

    DEFF Research Database (Denmark)

    Miller, Arne

    1974-01-01

    A single-pulse integrator is described. It gives a relative measure of the integral of the output signal from a coil monitor on the Risø 10 MeV linear accelerator, and displays the value on a digital voltmeter. The reproduccibility is found to be better than ±1% for an accelerated pulse charge...

  2. Integrated Inflammatory Stress (ITIS) Model

    DEFF Research Database (Denmark)

    Bangsgaard, Elisabeth O.; Hjorth, Poul G.; Olufsen, Mette S.

    2017-01-01

    maintains a long-term level of the stress hormone cortisol which is also anti-inflammatory. A new integrated model of the interaction between these two subsystems of the inflammatory system is proposed and coined the integrated inflammatory stress (ITIS) model. The coupling mechanisms describing...

  3. Cavalieri Integration | Ackermann | Quaestiones Mathematicae

    African Journals Online (AJOL)

    We also present two methods of evaluating a Cavalieri integral by first transforming it to either an equivalent Riemann or Riemann-Stieltjes integral by using special transformation functions h(x) and its inverse g(x), respectively. Interestingly enough it is often very difficult to find the transformation function h(x), whereas it is ...

  4. Investigating the Role of FIP200 in Mammary Carcinogenesis Using a Transgenic Mouse Model

    National Research Council Canada - National Science Library

    Nagy, Tamas

    2007-01-01

    ...) deletion in mammary-specific polyoma middle-T transgenic mice. We monitored mammary carcinogenesis in positive control (FAKFlox/Flox; MMTV-PyVT) and target (FAKFlox/Flox; MMTV-Cre; MMTV-PyVT) females...

  5. Smart systems integration and simulation

    CERN Document Server

    Poncino, Massimo; Pravadelli, Graziano

    2016-01-01

    This book-presents new methods and tools for the integration and simulation of smart devices. The design approach described in this book explicitly accounts for integration of Smart Systems components and subsystems as a specific constraint. It includes methodologies and EDA tools to enable multi-disciplinary and multi-scale modeling and design, simulation of multi-domain systems, subsystems and components at all levels of abstraction, system integration and exploration for optimization of functional and non-functional metrics. By covering theoretical and practical aspects of smart device design, this book targets people who are working and studying on hardware/software modelling, component integration and simulation under different positions (system integrators, designers, developers, researchers, teachers, students etc.). In particular, it is a good introduction to people who have interest in managing heterogeneous components in an efficient and effective way on different domains and different abstraction l...

  6. Integral equations and their applications

    CERN Document Server

    Rahman, M

    2007-01-01

    For many years, the subject of functional equations has held a prominent place in the attention of mathematicians. In more recent years this attention has been directed to a particular kind of functional equation, an integral equation, wherein the unknown function occurs under the integral sign. The study of this kind of equation is sometimes referred to as the inversion of a definite integral. While scientists and engineers can already choose from a number of books on integral equations, this new book encompasses recent developments including some preliminary backgrounds of formulations of integral equations governing the physical situation of the problems. It also contains elegant analytical and numerical methods, and an important topic of the variational principles. Primarily intended for senior undergraduate students and first year postgraduate students of engineering and science courses, students of mathematical and physical sciences will also find many sections of direct relevance. The book contains eig...

  7. Pipeline integrity : control by coatings

    Energy Technology Data Exchange (ETDEWEB)

    Khanna, A.S. [Indian Inst. of Technology, Bombay (India)

    2008-07-01

    This presentation provided background information on the history of cross-country pipelines in India. It discussed the major use of gas. The key users were described as being the power and fertilizer industries, followed by vehicles using compressed natural gas to replace liquid fuels and thereby reduce pollution. The presentation also addressed the integrity of pipelines in terms of high production, safety, and monitoring. Integrity issues of pipelines were discussed with reference to basic design, control of corrosion, and periodic health monitoring. Other topics that were outlined included integrity by corrosion control; integrity by health monitoring; coatings requirements; classification of UCC pipeline coatings; and how the pipeline integrity approach can help to achieve coatings which give design life without any failure. Surface cleanliness, coating conditions, and the relationship between temperature of Epoxy coating and the time of adhesive coating were also discussed. Last, the presentation provided the results of an audit of the HBJ pipeline conducted from 1999 to 2000. tabs., figs.

  8. Geophysical interpretation using integral equations

    CERN Document Server

    Eskola, L

    1992-01-01

    Along with the general development of numerical methods in pure and applied to apply integral equations to geophysical modelling has sciences, the ability improved considerably within the last thirty years or so. This is due to the successful derivation of integral equations that are applicable to the modelling of complex structures, and efficient numerical algorithms for their solution. A significant stimulus for this development has been the advent of fast digital computers. The purpose of this book is to give an idea of the principles by which boundary-value problems describing geophysical models can be converted into integral equations. The end results are the integral formulas and integral equations that form the theoretical framework for practical applications. The details of mathematical analysis have been kept to a minimum. Numerical algorithms are discussed only in connection with some illustrative examples involving well-documented numerical modelling results. The reader is assu­ med to have a back...

  9. Trade Liberalisation and Vertical Integration

    DEFF Research Database (Denmark)

    Bache, Peter Arendorf; Laugesen, Anders

    We build a three-country model of international trade in final goods and intermediate inputs and study the relation between different types of trade liberalisation and vertical integration. Firms are heterogeneous with respect to both productivity and factor intensity as observed in data. Final......-good producers face decisions on exporting, vertical integration of intermediate-input production, and whether the intermediate-input production should be offshored to a low-wage country. We find that the fractions of final-good producers that pursue either vertical integration, offshoring, or exporting are all...... increasing when intermediate-input or final-goods trade is liberalised and when the fixed cost of vertical integration is reduced. At the same time, one observes firms that shift away from either vertical integration, offshoring, or exporting. Further, we provide guidance for testing the open...

  10. Countering Integration Pessimists: New Differentiation for the Integration Debates

    Directory of Open Access Journals (Sweden)

    Matthias Kortmann

    2012-10-01

    Full Text Available In this article Leo and Jan Lucassen’s analysis in Winnaars en verliezers [Winners and losers] of 500 years of immigration to the Netherlands is reviewed with regard to possible conclusions for the neighbouring country, Germany. Particularly since the recent migration history in both countries has been very similar, the authors’ disentanglement of complex migration politics and their differentiated assessment of integration processes in the Netherlands are also useful for the occasionally pessimistic German migration and integration debate. The authors show that prevailing negativist views on the integration of migrants can be countered successfully with more sophisticated analyses of the integration of different migrant groups into different societal realms. Furthermore, their examination of the – predominantly positive – integration history of earlier centuries helps to put current short-term problems into perspective. Nevertheless their analysis has some methodological shortcomings as sometimes (negative quantitative results arecontrasted with (positive qualitative outcomes. Finally, policy conclusions would have been preferable, for example regarding the question of what can be learned from integration processes in previous centuries for integration problems of today.

  11. Integrated care needs integrated information management and technology.

    Science.gov (United States)

    Protti, Denis

    2009-01-01

    Integrated care entails that professionals from different organizations have to work together in a team-oriented way to provide high-quality care for a patient. This requires that healthcare professionals share information about--and with--patients at appropriate points in the care or treatment process. The necessary infrastructural arrangements--such as shared patient records, regional collaboration and a clear, transparent incentive structure--must be in place. It is increasingly hard to imagine integrative initiatives without a strong information management and technology component. However, information is a necessary condition but not sufficient to achieve integrated care; organizational change is the more critical component.

  12. Integrative structure modeling with the Integrative Modeling Platform.

    Science.gov (United States)

    Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano; Pellarin, Riccardo; Greenberg, Charles H; Saltzberg, Daniel; Sali, Andrej

    2018-01-01

    Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use. © 2017 The Protein Society.

  13. Integrating Sustainability in Management Education

    Directory of Open Access Journals (Sweden)

    Emmanuel Raufflet

    2013-10-01

    Full Text Available Over the last decade, numerous modules, courses, and programs in Management Education have integrated sustainability into their curricula. However, this “integration” has translated into very diverse forms and contents. This article aims to clarify these ambiguities. It maps four forms of sustainability integration in Management Education. These four distinct forms are (1 discipline-based integration, in which the anchoring point is the business discipline (sustainability is added as a dimension of this body of knowledge; (2 strategic-/competitive-based integration, in which the anchoring point is the strategy of the organization (sustainability is viewed as a potential contributor to the firm’s competitive advantage; (3 integration by application, in which managerial tools and approaches from business disciplines are applied so as to contribute to addressing a sustainability challenge; and, last, (4 systemic integration, in which the anchoring point is a social-ecological-economic challenge defined from an interdisciplinary perspective. Implications of this chapter for the design of courses and programs and the practice of sustainability in Management Education are twofold. First, this article contributes to going beyond the prevailing tendency of studies in the field of sustainability in Management Education to focus mainly on tools and applications. In doing so, this article helps frame these challenges on the level of course and program design. Second, this article helps management educators map what they are intending to achieve by the integration of sustainability into the Management Education curriculum.

  14. Integrated reporting and board features

    Directory of Open Access Journals (Sweden)

    Rares HURGHIS

    2017-02-01

    Full Text Available In the last two decades the concept of sustainability reporting gained more importance in the companies’ annual reports, a trend which is embedded also in integrated reporting. Issuing an integrated report became a necessity, because the report explains to the investors how the organization creates value over time. The governance structure, more exactly the board of directors, decides whether or not the company will issue an integrated report. Thus, are there certain features of the board that might influence the issue of an integrated report? Do the companies which issue an integrated report have certain features of the governance structure? Looking for an answer to these questions, we seek for any possible correlations between a disclosure index and the corporate governance structure characteristics, on a sample from the companies participating at the International Integrated Reporting Council Examples Database. The results highlight that only the size of the board influences the extent to which the issued integrated report is in accordance with the International Framework.

  15. What is an integrable quench?

    Directory of Open Access Journals (Sweden)

    Lorenzo Piroli

    2017-12-01

    Full Text Available Inspired by classical results in integrable boundary quantum field theory, we propose a definition of integrable initial states for quantum quenches in lattice models. They are defined as the states which are annihilated by all local conserved charges that are odd under space reflection. We show that this class includes the states which can be related to integrable boundary conditions in an appropriate rotated channel, in loose analogy with the picture in quantum field theory. Furthermore, we provide an efficient method to test integrability of given initial states. We revisit the recent literature of global quenches in several models and show that, in all of the cases where closed-form analytical results could be obtained, the initial state is integrable according to our definition. In the prototypical example of the XXZ spin-s chains we show that integrable states include two-site product states but also larger families of matrix product states with arbitrary bond dimension. We argue that our results could be practically useful for the study of quantum quenches in generic integrable models.

  16. Division algebras with integral elements

    International Nuclear Information System (INIS)

    Koca, M.; Ozdes, N.

    1988-06-01

    Pairing two elements of a given division algebra furnished with a multiplication rule leads to an algebra of higher dimension restricted by 8. This fact is used to obtain the roots of SO(4) and SP(2) from the roots ±1 of SU(2) and the weights ±1/2 of its spinor representation. The root lattice of SO(8) described by 24 integral quaternions are obtained by pairing two sets of roots of SP(2). The root system of F 4 is constructed in terms of 24 integral and 24 ''half-integral'' quaternions. The root lattice of E 8 expressed as 240 integral octonions are obtained by pairing two sets of roots of F 4 . 24 integral quaternions of SO(8) forming a discrete subgroup of SU(2) is shown to be the automorphism group of the root lattices of SO(8), F 4 and E 8 . The roots of maximal subgroups SO(16), E 7 XSU(2), E 6 XSU(3), SU(9) and SU(5)XSU(5) of E 8 are identified with a simple method. Subsets of the discrete subgroup of SU(2) leaving maximal subgroups of E 8 are obtained. Constructions of E 8 root lattice with integral octonions in 7 distinct ways are made. Magic square of integral lattices of Goddard, Nahm, Olive, Ruegg and Schwimmer are derived. Possible physical applications are suggested. (author). 16 refs, 6 figs, 5 tabs

  17. What is an integrable quench?

    Science.gov (United States)

    Piroli, Lorenzo; Pozsgay, Balázs; Vernier, Eric

    2017-12-01

    Inspired by classical results in integrable boundary quantum field theory, we propose a definition of integrable initial states for quantum quenches in lattice models. They are defined as the states which are annihilated by all local conserved charges that are odd under space reflection. We show that this class includes the states which can be related to integrable boundary conditions in an appropriate rotated channel, in loose analogy with the picture in quantum field theory. Furthermore, we provide an efficient method to test integrability of given initial states. We revisit the recent literature of global quenches in several models and show that, in all of the cases where closed-form analytical results could be obtained, the initial state is integrable according to our definition. In the prototypical example of the XXZ spin-s chains we show that integrable states include two-site product states but also larger families of matrix product states with arbitrary bond dimension. We argue that our results could be practically useful for the study of quantum quenches in generic integrable models.

  18. Interface-based software integration

    Directory of Open Access Journals (Sweden)

    Aziz Ahmad Rais

    2016-07-01

    Full Text Available Enterprise architecture frameworks define the goals of enterprise architecture in order to make business processes and IT operations more effective, and to reduce the risk of future investments. These enterprise architecture frameworks offer different architecture development methods that help in building enterprise architecture. In practice, the larger organizations become, the larger their enterprise architecture and IT become. This leads to an increasingly complex system of enterprise architecture development and maintenance. Application software architecture is one type of architecture that, along with business architecture, data architecture and technology architecture, composes enterprise architecture. From the perspective of integration, enterprise architecture can be considered a system of interaction between multiple examples of application software. Therefore, effective software integration is a very important basis for the future success of the enterprise architecture in question. This article will provide interface-based integration practice in order to help simplify the process of building such a software integration system. The main goal of interface-based software integration is to solve problems that may arise with software integration requirements and developing software integration architecture.

  19. New Integral Inequalities for Iterated Integrals with Applications

    Directory of Open Access Journals (Sweden)

    Ryoo Cheon Seoung

    2007-01-01

    Full Text Available Some new nonlinear retarded integral inequalities of Gronwall type are established. These inequalities can be used as basic tools in the study of certain classes of integrodifferential equations.

  20. Applying recursive numerical integration techniques for solving high dimensional integrals

    Energy Technology Data Exchange (ETDEWEB)

    Ammon, Andreas [IVU Traffic Technologies AG, Berlin (Germany); Genz, Alan [Washington State Univ., Pullman, WA (United States). Dept. of Mathematics; Hartung, Tobias [King' s College, London (United Kingdom). Dept. of Mathematics; Jansen, Karl; Volmer, Julia [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Leoevey, Hernan [Humboldt Univ. Berlin (Germany). Inst. fuer Mathematik

    2016-11-15

    The error scaling for Markov-Chain Monte Carlo techniques (MCMC) with N samples behaves like 1/√(N). This scaling makes it often very time intensive to reduce the error of computed observables, in particular for applications in lattice QCD. It is therefore highly desirable to have alternative methods at hand which show an improved error scaling. One candidate for such an alternative integration technique is the method of recursive numerical integration (RNI). The basic idea of this method is to use an efficient low-dimensional quadrature rule (usually of Gaussian type) and apply it iteratively to integrate over high-dimensional observables and Boltzmann weights. We present the application of such an algorithm to the topological rotor and the anharmonic oscillator and compare the error scaling to MCMC results. In particular, we demonstrate that the RNI technique shows an error scaling in the number of integration points m that is at least exponential.