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  1. Dose control programme of Hot Cell facility at Isotope Wing

    International Nuclear Information System (INIS)

    Sapkal, Jyotsna A.; Suresh, Manju; Shreenivas, V.; Amruta, C.T.; Yadav, R.K.B.; Gopalkrishanan, R.K.; Patil, B.N.; Sastry, K.V.S.

    2015-01-01

    Hot Cell Facility of Board of Radiation Isotope Technology (BRIT) at Radiological Laboratories (RLG) is involved in fabrication of sealed radioisotopes like Cobalt-60, Cesium-137 and Iridium-192 radioisotopes which are widely used for various medical and industrial applications. In the field of Medicine, above radioactive sources are used for treatment procedures such as Teletherapy and Brachytherapy. 192 Ir radioisotope is widely used for industrial radiography particularly for non-destructive testing of welds in steel in the oil and gas industries. In spite of the increased production of these radioisotopes to meet the requirements from medical and industrial sector, the annual Collective Dose for BRIT facility, during 2011-2013 has shown a downward trend. This paper describes in brief the measures adopted by the facility based on the radiological safety inputs provided by Radiation Hazards Control (RHC) Unit of Isotope Wing, RLG for reducing the collective dose during year 2012 and 2013 by nearly 40% of collective dose consumed for year-2011. Strict implementation of the radiological safety measures during handling of radioactive sources, administrative controls and engineered safety measures resulted in lowering of collective dose during year 2011-2013. (author)

  2. Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    OpenAIRE

    Etournay, Raphaël; Popović, Marko; Merkel, Matthias; Nandi, Amitabha; Blasse, Corinna; Aigouy, Benoît; Brandl, Holger; Myers, Gene; Salbreux, Guillaume; Jülicher, Frank; Eaton, Suzanne

    2015-01-01

    eLife digest The individual cells in a developing animal embryo organize themselves into tissues with specific and reproducible shapes, which requires the cells to communicate with one another. Cells in tissues exert forces on their neighbors, and respond to being pushed and pulled by the cells around them. In the fruit fly Drosophila melanogaster, each wing consists mainly of a framework of proteins and other molecules that is built by epithelial cells. These epithelial cells divide and grow...

  3. FijiWingsPolarity: An open source toolkit for semi-automated detection of cell polarity.

    Science.gov (United States)

    Dobens, Leonard L; Shipman, Anna; Axelrod, Jeffrey D

    2017-12-22

    Epithelial cells are defined by apical-basal and planar cell polarity (PCP) signaling, the latter of which establishes an orthogonal plane of polarity in the epithelial sheet. PCP signaling is required for normal cell migration, differentiation, stem cell generation and tissue repair, and defects in PCP have been associated with developmental abnormalities, neuropathologies and cancers. While the molecular mechanism of PCP is incompletely understood, the deepest insights have come from Drosophila, where PCP is manifest in hairs and bristles across the adult cuticle and organization of the ommatidia in the eye. Fly wing cells are marked by actin-rich trichome structures produced at the distal edge of each cell in the developing wing epithelium and in a mature wing the trichomes orient collectively in the distal direction. Genetic screens have identified key PCP signaling pathway components that disrupt trichome orientation, which has been measured manually in a tedious and error prone process. Here we describe a set of image processing and pattern-recognition macros that can quantify trichome arrangements in micrographs and mark these directly by color, arrow or colored arrow to indicate trichome location, length and orientation. Nearest neighbor calculations are made to exploit local differences in orientation to better and more reliably detect and highlight local defects in trichome polarity. We demonstrate the use of these tools on trichomes in adult wing preps and on actin-rich developing trichomes in pupal wing epithelia stained with phalloidin. FijiWingsPolarity is freely available and will be of interest to a broad community of fly geneticists studying the effect of gene function on PCP.

  4. Mechanisms of Regulating Tissue Elongation in Drosophila Wing: Impact of Oriented Cell Divisions, Oriented Mechanical Forces, and Reduced Cell Size

    Science.gov (United States)

    Li, Yingzi; Naveed, Hammad; Kachalo, Sema; Xu, Lisa X.; Liang, Jie

    2014-01-01

    Regulation of cell growth and cell division plays fundamental roles in tissue morphogenesis. However, the mechanisms of regulating tissue elongation through cell growth and cell division are still not well understood. The wing imaginal disc of Drosophila provides a model system that has been widely used to study tissue morphogenesis. Here we use a recently developed two-dimensional cellular model to study the mechanisms of regulating tissue elongation in Drosophila wing. We simulate the effects of directional cues on tissue elongation. We also computationally analyze the role of reduced cell size. Our simulation results indicate that oriented cell divisions, oriented mechanical forces, and reduced cell size can all mediate tissue elongation, but they function differently. We show that oriented cell divisions and oriented mechanical forces act as directional cues during tissue elongation. Between these two directional cues, oriented mechanical forces have a stronger influence than oriented cell divisions. In addition, we raise the novel hypothesis that reduced cell size may significantly promote tissue elongation. We find that reduced cell size alone cannot drive tissue elongation. However, when combined with directional cues, such as oriented cell divisions or oriented mechanical forces, reduced cell size can significantly enhance tissue elongation in Drosophila wing. Furthermore, our simulation results suggest that reduced cell size has a short-term effect on cell topology by decreasing the frequency of hexagonal cells, which is consistent with experimental observations. Our simulation results suggest that cell divisions without cell growth play essential roles in tissue elongation. PMID:24504016

  5. Mathematical modeling of planar cell polarity signaling in the Drosophila melanogaster wing

    Science.gov (United States)

    Amonlirdviman, Keith

    Planar cell polarity (PCP) signaling refers to the coordinated polarization of cells within the plane of various epithelial tissues to generate sub-cellular asymmetry along an axis orthogonal to their apical-basal axes. For example, in the Drosophila wing, PCP is seen in the parallel orientation of hairs that protrude from each of the approximately 30,000 epithelial cells to robustly point toward the wing tip. Through a poorly understood mechanism, cell clones mutant for some PCP signaling components, including some, but not all alleles of the receptor frizzled, cause polarity disruptions of neighboring, wild-type cells, a phenomenon referred to as domineering nonautonomy. Previous models have proposed diffusible factors to explain nonautonomy, but no such factors have yet been found. This dissertation describes the mathematical modeling of PCP in the Drosophila wing, based on a contact dependent signaling hypothesis derived from experimental results. Intuition alone is insufficient to deduce that this hypothesis, which relies on a local feedback loop acting at the cell membrane, underlies the complex patterns observed in large fields of cells containing mutant clones, and others have argued that it cannot account for observed phenotypes. Through reaction-diffusion, partial differential equation modeling and simulation, the feedback loop is shown to fully reproduce PCP phenotypes, including domineering nonautonomy. The sufficiency of this model and the experimental validation of model predictions argue that previously proposed diffusible factors need not be invoked to explain PCP signaling and reveal how specific protein-protein interactions lead to autonomy or domineering nonautonomy. Based on these results, an ordinary differential equation model is derived to study the relationship of the feedback loop with upstream signaling components. The cadherin Fat transduces a cue to the local feedback loop, biasing the polarity direction of each cell toward the wing tip

  6. Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium.

    Science.gov (United States)

    Wortman, Juliana C; Nahmad, Marcos; Zhang, Peng Cheng; Lander, Arthur D; Yu, Clare C

    2017-07-01

    In developing tissues, cell polarization and proliferation are regulated by morphogens and signaling pathways. Cells throughout the Drosophila wing primordium typically show subcellular localization of the unconventional myosin Dachs on the distal side of cells (nearest the center of the disc). Dachs localization depends on the spatial distribution of bonds between the protocadherins Fat (Ft) and Dachsous (Ds), which form heterodimers between adjacent cells; and the Golgi kinase Four-jointed (Fj), which affects the binding affinities of Ft and Ds. The Fj concentration forms a linear gradient while the Ds concentration is roughly uniform throughout most of the wing pouch with a steep transition region that propagates from the center to the edge of the pouch during the third larval instar. Although the Fj gradient is an important cue for polarization, it is unclear how the polarization is affected by cell division and the expanding Ds transition region, both of which can alter the distribution of Ft-Ds heterodimers around the cell periphery. We have developed a computational model to address these questions. In our model, the binding affinity of Ft and Ds depends on phosphorylation by Fj. We assume that the asymmetry of the Ft-Ds bond distribution around the cell periphery defines the polarization, with greater asymmetry promoting cell proliferation. Our model predicts that this asymmetry is greatest in the radially-expanding transition region that leaves polarized cells in its wake. These cells naturally retain their bond distribution asymmetry after division by rapidly replenishing Ft-Ds bonds at new cell-cell interfaces. Thus we predict that the distal localization of Dachs in cells throughout the pouch requires the movement of the Ds transition region and the simple presence, rather than any specific spatial pattern, of Fj.

  7. Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids.

    Science.gov (United States)

    Okada, Yukio; Miyazaki, Toshihiro; Fujiyama, Rie; Toda, Kazuo

    2013-11-01

    The effects of unsaturated fatty acids on membrane properties were studied using conventional whole-cell patch-clamp recording of isolated wing (Ib) cells in bullfrog (Lithobates catesbeianus) taste discs. Applying arachidonic acid to the bath induced monophasic inward currents in 60% of wing cells and biphasic inward and outward currents in the other cells. The intracellular dialysis of arachidonic acid did not induce an inward current; however, it enhanced a slowly developing Ba(2+)-sensitive outward current. The effects of various unsaturated fatty acids were explored under the condition of Cs(+) internal solution. Linoleic and α-linolenic acids induced large inward currents. Oleic, eicosapentaenoic and docosahexaenoic acids elicited the same inward currents as those of arachidonic acid. Wing cells, under the basal condition with Cs(+) internal solution, displayed a small inward current of -1.1±0.1pA/pF at -50mV (n=40), in which the peak existed at a membrane potential of -49mV. Removing external Ca(2+) further increased the inward current by -2.9±0.3pA/pF at -50mV (n=4) from the basal current and the peak was located at -55mV. External linoleic acid (50μM) also induced a similar inward current of -5.6±0.6pA/pF at -50mV (n=19) from the basal current and the peak was located at -61mV. External Ca(2+)-free saline and linoleic acid induced similar current/voltage (I/V) relationships elicited by a ramp voltage as well as voltage steps. Linoleic acid-induced currents were not influenced by replacing internal EGTA with BAPTA, whereas inward currents disappeared under the elimination of external Na(+) and addition of flufenamic acid. These results suggest that dietary unsaturated fatty acids may depolarize wing (Ib) cells, which affects the excitability of these cells. © 2013.

  8. Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines

    Directory of Open Access Journals (Sweden)

    Franziska Hauth

    2017-08-01

    Conclusion: We herein report a key role of ATM in the cellular fitness of cells exposed to prolonged moderate hypoxia prior to irradiation. While DNA damage response post-irradiation seem to be mainly driven by non-homologous end joining repair pathway in these conditions, our data suggest an important role for ATM kinase in hypoxia-driven modification of radiation response.

  9. Butterflies regulate wing temperatures using radiative cooling

    Science.gov (United States)

    Tsai, Cheng-Chia; Shi, Norman Nan; Ren, Crystal; Pelaez, Julianne; Bernard, Gary D.; Yu, Nanfang; Pierce, Naomi

    2017-09-01

    Butterfly wings are live organs embedded with multiple sensory neurons and, in some species, with pheromoneproducing cells. The proper function of butterfly wings demands a suitable temperature range, but the wings can overheat quickly in the sun due to their small thermal capacity. We developed an infrared technique to map butterfly wing temperatures and discovered that despite the wings' diverse visible colors, regions of wings that contain live cells are the coolest, resulting from the thickness of the wings and scale nanostructures. We also demonstrated that butterflies use behavioral traits to prevent overheating of their wings.

  10. New treatment options for metastatic renal cell carcinoma with prior anti-angiogenesis therapy.

    Science.gov (United States)

    Zarrabi, Kevin; Fang, Chunhui; Wu, Shenhong

    2017-02-02

    Angiogenesis is a critical process in the progression of advanced renal cell carcinoma. Agents targeting angiogenesis have played a primary role in the treatment of metastatic renal cell carcinoma. However, resistance to anti-angiogenesis therapy almost always occurs, and major progress has been made in understanding its underlying molecular mechanism. Axitinib and everolimus have been used extensively in patients whom have had disease progression after prior anti-angiogenesis therapy. Recently, several new agents have been shown to improve overall survival in comparison with everolimus. This review provides an in-depth summary of drugs employable in the clinical setting, the rationale to their use, and the studies conducted leading to their approval for use and provides perspective on the paradigm shift in the treatment of renal cell carcinoma. Highlighted are the newly approved agents cabozantinib, nivolumab, and lenvatinib for advanced renal cell carcinoma patients treated with prior anti-angiogenesis therapy.

  11. New treatment options for metastatic renal cell carcinoma with prior anti-angiogenesis therapy

    Directory of Open Access Journals (Sweden)

    Kevin Zarrabi

    2017-02-01

    Full Text Available Abstract Angiogenesis is a critical process in the progression of advanced renal cell carcinoma. Agents targeting angiogenesis have played a primary role in the treatment of metastatic renal cell carcinoma. However, resistance to anti-angiogenesis therapy almost always occurs, and major progress has been made in understanding its underlying molecular mechanism. Axitinib and everolimus have been used extensively in patients whom have had disease progression after prior anti-angiogenesis therapy. Recently, several new agents have been shown to improve overall survival in comparison with everolimus. This review provides an in-depth summary of drugs employable in the clinical setting, the rationale to their use, and the studies conducted leading to their approval for use and provides perspective on the paradigm shift in the treatment of renal cell carcinoma. Highlighted are the newly approved agents cabozantinib, nivolumab, and lenvatinib for advanced renal cell carcinoma patients treated with prior anti-angiogenesis therapy.

  12. Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans.

    Science.gov (United States)

    Grifoni, Alba; Pham, John; Sidney, John; O'Rourke, Patrick H; Paul, Sinu; Peters, Bjoern; Martini, Sheridan R; de Silva, Aruna D; Ricciardi, Michael J; Magnani, Diogo M; Silveira, Cassia G T; Maestri, Alvino; Costa, Priscilla R; de-Oliveira-Pinto, Luzia Maria; de Azeredo, Elzinandes Leal; Damasco, Paulo Vieira; Phillips, Elizabeth; Mallal, Simon; de Silva, Aravinda M; Collins, Matthew; Durbin, Anna; Diehl, Sean A; Cerpas, Cristhiam; Balmaseda, Angel; Kuan, Guillermina; Coloma, Josefina; Harris, Eva; Crowe, James E; Stone, Mars; Norris, Phillip J; Busch, Michael; Vivanco-Cid, Hector; Cox, Josephine; Graham, Barney S; Ledgerwood, Julie E; Turtle, Lance; Solomon, Tom; Kallas, Esper G; Watkins, David I; Weiskopf, Daniela; Sette, Alessandro

    2017-10-04

    While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known regarding the corresponding T cell responses to ZIKV. Here we investigate the kinetics and viral epitopes targeted by T cells responding to ZIKV and address the critical question of whether pre-existing dengue virus (DENV) T cell immunity modulates these responses. We find that memory T cell responses elicited by prior infection with DENV or vaccination with Tetravalent Dengue Attenuated Vaccines (TDLAV) recognize ZIKV-derived peptides. This cross-reactivity is explained by the sequence similarity of the two viruses, as the ZIKV peptides recognized by DENV-elicited memory T cells are identical or highly conserved in DENV and ZIKV. DENV exposure prior to ZIKV infection also influences the timing and magnitude of the T cell response. ZIKV-reactive T cells in the acute phase of infection are detected earlier and in greater magnitude in DENV-immune patients. Conversely, the frequency of ZIKV-reactive T cells continues to rise in the convalescent phase in DENV-naive donors, but declines in DENV pre-exposed donors, compatible with more efficient control of ZIKV replication and/or clearance of ZIKV antigen. The quality of responses is also influenced by previous DENV exposure, and ZIKV-specific CD8 T cells form DENV pre-exposed donors selectively up-regulated granzyme B and PD1, as compared to DENV-naïve donors. Finally, we discovered that ZIKV structural proteins (E, prM and C) are major targets of both the CD4 and CD8 T cell responses, whereas DENV T cell epitopes are found primarily in nonstructural proteins. IMPORTANCE The issue of potential ZIKV and DENV cross-reactivity and how pre-existing DENV T cell immunity modulates ZIKA T cell responses is of great relevance as the two viruses often co-circulate and ZIKA virus has been spreading in geographical regions where DENV is endemic or hyper-endemic. Our data show that memory T cell responses elicited by

  13. The costae presenting in high-temperature-induced vestigial wings ...

    Indian Academy of Sciences (India)

    Most of the wings have defects in the wing blade and partially formed wing margin, which are the result of autonomous cell death in the ... [Yang D. 2007 The costae presenting in high-temperature-induced vestigial wings of Drosophila: implications for anterior wing margin formation. J. Genet. .... The relevant gene(s) may be.

  14. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.

    Science.gov (United States)

    Soyer, Josselin; Flasse, Lydie; Raffelsberger, Wolfgang; Beucher, Anthony; Orvain, Christophe; Peers, Bernard; Ravassard, Philippe; Vermot, Julien; Voz, Marianne L; Mellitzer, Georg; Gradwohl, Gérard

    2010-01-01

    The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification in multipotent pancreatic progenitor cells in the mouse embryo. However, our knowledge of the genetic programs implemented by Ngn3, which control generic and islet subtype-specific properties, is still fragmentary. Gene expression profiling in isolated Ngn3-positive progenitor cells resulted in the identification of the uncharacterized winged helix transcription factor Rfx6. Rfx6 is initially expressed broadly in the gut endoderm, notably in Pdx1-positive cells in the developing pancreatic buds, and then becomes progressively restricted to the endocrine lineage, suggesting a dual function in both endoderm development and islet cell differentiation. Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. Rfx6 is dependent on Ngn3 and acts upstream of or in parallel with NeuroD, Pax4 and Arx transcription factors during islet cell differentiation. In zebrafish, the Rfx6 ortholog is similarly found in progenitors and hormone expressing cells of the islet lineage. Loss-of-function studies in zebrafish revealed that rfx6 is required for the differentiation of glucagon-, ghrelin- and somatostatin-expressing cells, which, in the absence of rfx6, are blocked at the progenitor stage. By contrast, beta cells, whose number is only slightly reduced, were no longer clustered in a compact islet. These data unveil Rfx6 as a novel regulator of islet cell development.

  15. Modelling condensation and the initiation of chondrogenesis in chick wing bud mesenchymal cells levitated in an ultrasound trap

    Directory of Open Access Journals (Sweden)

    GO Edwards

    2010-01-01

    Full Text Available Chick wing bud mesenchymal cell micromass culture allows the study of a variety of developmental mechanisms, ranging from cell adhesion to pattern formation. However, many cells remain in contact with an artificial substratum, which can influence cytoskeletal organisation and differentiation. An ultrasound standing wave trap facilitates the rapid formation of 2-D monolayer cell aggregates with a defined zero time-point, independent from contact with a surface. Aggregates formed rapidly (within 2 min and intercellular membrane spreading occurred at points of contact. This was associated with an increase in peripheral F-actin within 10 min of cell-cell contact and aggregates had obtained physical integrity by 30 min. The chondrogenic transcription factor Sox9 could be detected in cells in the ultrasound trap within 3 h (ultrasound exposure alone was not responsible for this effect. This approach facilitates the study of the initial cell-cell interactions that occur during condensation formation and demonstrates that a combination of cell shape and cytoskeletal organisation is required for the initiation and maintenance of a differentiated phenotype, which is lost when these phenomena are influenced by contact with an artificial substrate.

  16. Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells.

    Science.gov (United States)

    Bargaje, Rhishikesh; Trachana, Kalliopi; Shelton, Martin N; McGinnis, Christopher S; Zhou, Joseph X; Chadick, Cora; Cook, Savannah; Cavanaugh, Christopher; Huang, Sui; Hood, Leroy

    2017-02-28

    Steering the differentiation of induced pluripotent stem cells (iPSCs) toward specific cell types is crucial for patient-specific disease modeling and drug testing. This effort requires the capacity to predict and control when and how multipotent progenitor cells commit to the desired cell fate. Cell fate commitment represents a critical state transition or "tipping point" at which complex systems undergo a sudden qualitative shift. To characterize such transitions during iPSC to cardiomyocyte differentiation, we analyzed the gene expression patterns of 96 developmental genes at single-cell resolution. We identified a bifurcation event early in the trajectory when a primitive streak-like cell population segregated into the mesodermal and endodermal lineages. Before this branching point, we could detect the signature of an imminent critical transition: increase in cell heterogeneity and coordination of gene expression. Correlation analysis of gene expression profiles at the tipping point indicates transcription factors that drive the state transition toward each alternative cell fate and their relationships with specific phenotypic readouts. The latter helps us to facilitate small molecule screening for differentiation efficiency. To this end, we set up an analysis of cell population structure at the tipping point after systematic variation of the protocol to bias the differentiation toward mesodermal or endodermal cell lineage. We were able to predict the proportion of cardiomyocytes many days before cells manifest the differentiated phenotype. The analysis of cell populations undergoing a critical state transition thus affords a tool to forecast cell fate outcomes and can be used to optimize differentiation protocols to obtain desired cell populations.

  17. The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings.

    Science.gov (United States)

    Rougeot, Julien; Renard, Myrtille; Randsholt, Neel B; Peronnet, Frédérique; Mouchel-Vielh, Emmanuèle

    2013-01-01

    Drosophila wings mainly consist of two cell types, vein and intervein cells. Acquisition of either fate depends on specific expression of genes that are controlled by several signaling pathways. The nuclear mechanisms that translate signaling into regulation of gene expression are not completely understood, but they involve chromatin factors from the Trithorax (TrxG) and Enhancers of Trithorax and Polycomb (ETP) families. One of these is the ETP Corto that participates in intervein fate through interaction with the Drosophila EGF Receptor--MAP kinase ERK pathway. Precise mechanisms and molecular targets of Corto in this process are not known. We show here that Corto interacts with the Elongin transcription elongation complex. This complex, that consists of three subunits (Elongin A, B, C), increases RNA polymerase II elongation rate in vitro by suppressing transient pausing. Analysis of phenotypes induced by EloA, B, or C deregulation as well as genetic interactions suggest that the Elongin complex might participate in vein vs intervein specification, and antagonizes corto as well as several TrxG genes in this process. Chromatin immunoprecipitation experiments indicate that Elongin C and Corto bind the vein-promoting gene rhomboid in wing imaginal discs. We propose that Corto and the Elongin complex participate together in vein vs intervein fate, possibly through tissue-specific transcriptional regulation of rhomboid.

  18. The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings.

    Directory of Open Access Journals (Sweden)

    Julien Rougeot

    Full Text Available Drosophila wings mainly consist of two cell types, vein and intervein cells. Acquisition of either fate depends on specific expression of genes that are controlled by several signaling pathways. The nuclear mechanisms that translate signaling into regulation of gene expression are not completely understood, but they involve chromatin factors from the Trithorax (TrxG and Enhancers of Trithorax and Polycomb (ETP families. One of these is the ETP Corto that participates in intervein fate through interaction with the Drosophila EGF Receptor--MAP kinase ERK pathway. Precise mechanisms and molecular targets of Corto in this process are not known. We show here that Corto interacts with the Elongin transcription elongation complex. This complex, that consists of three subunits (Elongin A, B, C, increases RNA polymerase II elongation rate in vitro by suppressing transient pausing. Analysis of phenotypes induced by EloA, B, or C deregulation as well as genetic interactions suggest that the Elongin complex might participate in vein vs intervein specification, and antagonizes corto as well as several TrxG genes in this process. Chromatin immunoprecipitation experiments indicate that Elongin C and Corto bind the vein-promoting gene rhomboid in wing imaginal discs. We propose that Corto and the Elongin complex participate together in vein vs intervein fate, possibly through tissue-specific transcriptional regulation of rhomboid.

  19. HEMATOPOIETIC PROGENITOR CELLS AS A PREDICTIVE OF CD34+ ENUMERATION PRIOR TO PERIPHERAL BLOOD STEM CELLS HARVESTING

    Directory of Open Access Journals (Sweden)

    Z. Zulkafli

    2014-09-01

    Full Text Available Background: To date, the CD34+ cell enumeration has relied predominantly on flow cytometry technique. However, flow cytometry is time consuming and operator dependent. The application of the hematopoietic progenitor cells (HPCs channel in Sysmex XE-2100, a fully automated hematology analyzer offers an alternative approach, which is with minimal sample manipulation and less operator dependent. This study evaluates the utility of HPC counts as a predictive of CD34+ enumeration prior to peripheral blood stem cells harvesting. Materials and methods: HPC, CD34+, white blood cell (WBC, reticulocytes (retic, immature platelet fraction (IPF and immature reticulocyte fraction (IRF were determined in 61 samples from 19 patients with hematological malignancies (15 lymphoma and 4 multiple myeloma patients at Hospital Universiti Sains Malaysia (Hospital USM who had received granulocyte-colony stimulating factor (G-CSF and planned for autologous transplantation. Results: CD34+ count showed strong and significant correlation with HPC. The receiver operating characteristics (ROC curve analysis revealed that HPC count > 21.5 x 106 / L can predicts a pre harvest CD34+ count of >20 x 106 / L with sensitivity of 77%, specificity of 64% and area under the curve (AUC of 0.802. Conclusion: We concluded that HPC count can be a useful potential parameter in optimizing timing for CD34+ enumeration prior to leukapheresis.

  20. Hematopoietic stem cell transplant candidate and designated proxy distress levels prior to hematopoietic stem cell transplantation.

    Science.gov (United States)

    Duckworth, Katharine E; Forti, Allison M; Russell, Gregory B; Naik, Seema; Hurd, David D; McQuellon, Richard P

    2014-12-01

    Hematopoietic stem cell transplantation (HCT) is associated with a high risk of morbidity, making advance care planning (ACP) essential. The purpose of this study was to assess and compare proxy and HCT candidate distress levels (Distress Thermometer) before (T1) and after (T2) ACP question completion. 79 participants (40 HCT candidates, 39 proxies) rated their distress. The T1, T2 mean distress scores (SD) for HCT candidates were 3.13(2.27), 2.96(2.10); 43% and 38% endorsed clinically significant distress (≥4). Proxies reported 4.21(2.48), 4.33 (2.46); 62% endorsed significant distress at T1, T2. The majority of proxies endorsed distress levels that were clinically significant and comparatively higher (T1 (p = 0.047) and T2 (p = 0.009)) than their paired HCT recipients. Responding to questions about ACP did not increase overall distress ratings. © The Author(s) 2013.

  1. The bHLH factors Dpn and members of the E(spl complex mediate the function of Notch signalling regulating cell proliferation during wing disc development

    Directory of Open Access Journals (Sweden)

    Beatriz P. San Juan

    2012-05-01

    The Notch signalling pathway plays an essential role in the intricate control of cell proliferation and pattern formation in many organs during animal development. In addition, mutations in most members of this pathway are well characterized and frequently lead to tumour formation. The Drosophila imaginal wing discs have provided a suitable model system for the genetic and molecular analysis of the different pathway functions. During disc development, Notch signalling at the presumptive wing margin is necessary for the restricted activation of genes required for pattern formation control and disc proliferation. Interestingly, in different cellular contexts within the wing disc, Notch can either promote cell proliferation or can block the G1-S transition by negatively regulating the expression of dmyc and bantam micro RNA. The target genes of Notch signalling that are required for these functions have not been identified. Here, we show that the Hes vertebrate homolog, deadpan (dpn, and the Enhancer-of-split complex (E(splC genes act redundantly and cooperatively to mediate the Notch signalling function regulating cell proliferation during wing disc development.

  2. Prior endurance exercise prevents postprandial lipaemia-induced increases in reactive oxygen species in circulating CD31+ cells.

    Science.gov (United States)

    Jenkins, Nathan T; Landers, Rian Q; Thakkar, Sunny R; Fan, Xiaoxuan; Brown, Michael D; Prior, Steven J; Spangenburg, Espen E; Hagberg, James M

    2011-11-15

    We hypothesized that prior exercise would prevent postprandial lipaemia (PPL)-induced increases in intracellular reactive oxygen species (ROS) in three distinct circulating angiogenic cell (CAC) subpopulations. CD34(+), CD31(+)/CD14(-)/CD34(-), and CD31(+)/CD14(+)/CD34(-) CACs were isolated from blood samples obtained from 10 healthy men before and 4 h after ingesting a high fat meal with or without ∼50 min of prior endurance exercise. Significant PPL-induced increases in ROS production in both sets of CD31(+) cells were abolished by prior exercise. Experimental ex vivo inhibition of NADPH oxidase activity and mitochondrial ROS production indicated that mitochondria were the primary source of PPL-induced oxidative stress. The attenuated increases in ROS with prior exercise were associated with increased antioxidant gene expression in CD31(+)/CD14(-)/CD34(-) cells and reduced intracellular lipid uptake in CD31(+)/CD14(+)/CD34(-) cells. These findings were associated with systemic cardiovascular benefits of exercise, as serum triglyceride, oxidized low density lipoprotein-cholesterol, and plasma endothelial microparticle concentrations were lower in the prior exercise trial than the control trial. In conclusion, prior exercise completely prevents PPL-induced increases in ROS in CD31(+)/CD14(-)/CD34(-) and CD31(+)/CD14(+)/CD34(-) cells. The mechanisms underlying the effects of exercise on CAC function appear to vary among specific CAC types.

  3. Correlation of transcranial Doppler ultrasonography with MRI and MRA in the evaluation of sickle cell disease patients with prior stroke

    International Nuclear Information System (INIS)

    Kogutt, M.S.; Goldwag, S.S.; Gupta, K.L.; Kaneko, K.; Humbert, J.R.

    1994-01-01

    We prospectively evaluated a group of patients with sickle cell disease and a clinical history of prior stroke, comparing transcranial Doppler sonography (TCD) to both magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) to determine its efficacy for the detection of flow abnormalities associated with prior cerebral infarction. Using MRI as the standard examination, there was 94 % sensitivity and 30 % specificity, and using MRA as the standard examination, there was 91 % sensitivity and 22 % specificity. We concur with other reports that the transcranial Doppler examination is a highly sensitive study. In our group of sickle cell disease patients with prior stroke, TCD reliably detected flow abnormalities that correlated to areas of prior cerebral infarction. (orig.)

  4. Correlation of transcranial Doppler ultrasonography with MRI and MRA in the evaluation of sickle cell disease patients with prior stroke

    Energy Technology Data Exchange (ETDEWEB)

    Kogutt, M.S. (Dept. of Radiology SL54, Tulane Univ. Medical Center, New Orleans, LA (United States)); Goldwag, S.S. (Dept. of Radiology SL54, Tulane Univ. Medical Center, New Orleans, LA (United States)); Gupta, K.L. (Dept. of Radiology SL54, Tulane Univ. Medical Center, New Orleans, LA (United States)); Kaneko, K. (Dept. of Radiology SL54, Tulane Univ. Medical Center, New Orleans, LA (United States)); Humbert, J.R. (Dept. of Pediatric Hematology and Oncology, Tulane Univ. Medical Center, New Orleans, LA (United States))

    1994-06-01

    We prospectively evaluated a group of patients with sickle cell disease and a clinical history of prior stroke, comparing transcranial Doppler sonography (TCD) to both magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) to determine its efficacy for the detection of flow abnormalities associated with prior cerebral infarction. Using MRI as the standard examination, there was 94 % sensitivity and 30 % specificity, and using MRA as the standard examination, there was 91 % sensitivity and 22 % specificity. We concur with other reports that the transcranial Doppler examination is a highly sensitive study. In our group of sickle cell disease patients with prior stroke, TCD reliably detected flow abnormalities that correlated to areas of prior cerebral infarction. (orig.)

  5. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Serial Measurements of Apoptotic Cell Numbers Provide Better Acceptance Criterion for PBMC Quality than a Single Measurement Prior to the T Cell Assay

    Directory of Open Access Journals (Sweden)

    Marie Wunsch

    2015-01-01

    Full Text Available As soon as Peripheral Blood Mononuclear Cells (PBMC are isolated from whole blood, some cells begin dying. The rate of apoptotic cell death is increased when PBMC are shipped, cryopreserved, or stored under suboptimal conditions. Apoptotic cells secrete cytokines that suppress inflammation while promoting phagocytosis. Increased numbers of apoptotic cells in PBMC may modulate T cell functions in antigen-triggered T cell assays. We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of large numbers of apoptotic B cells did not affect T cell functionality. In contrast, when PBMC were stored under unfavorable conditions, leading to damage and apoptosis in the T cells as well as bystander cells, T cell functionality was greatly impaired. We observed that measuring the number of apoptotic cells before plating the PBMC into an ELISPOT assay did not reflect the extent of PBMC injury, but measuring apoptotic cell frequencies at the end of the assay did. Our data suggest that measuring the numbers of apoptotic cells prior to and post T cell assays may provide more stringent PBMC quality acceptance criteria than measurements done only prior to the start of the assay.

  7. Design of a Five-Axis Load Cell for Submerged Wing Testing in an Oil Tank

    Science.gov (United States)

    2011-12-01

    resulting in a change in their resistance. Voltage is then measured through the output of a Wheatstone bridge circuit and sensed using an amplifier...imposed on the structure of the load cell to measurable electrical signals. The common technique of using a wheatstone bridge with strain-varying...conceptual design. The electrical circuit design is described in detail, including the design of the bridge circuits used, gauge placement, and

  8. Partial regulatory T cell depletion prior to acute feline immunodeficiency virus infection does not alter disease pathogenesis.

    Directory of Open Access Journals (Sweden)

    S Rochelle Mikkelsen

    2011-02-01

    Full Text Available Feline immunodeficiency virus (FIV infection in cats follows a disease course similar to HIV-1, including a short acute phase characterized by high viremia, and a prolonged asymptomatic phase characterized by low viremia and generalized immune dysfunction. CD4(+CD25(hiFoxP3(+ immunosuppressive regulatory T (Treg cells have been implicated as a possible cause of immune dysfunction during FIV and HIV-1 infection, as they are capable of modulating virus-specific and inflammatory immune responses. Additionally, the immunosuppressive capacity of feline Treg cells has been shown to be increased during FIV infection. We have previously shown that transient in vivo Treg cell depletion during asymptomatic FIV infection reveals FIV-specific immune responses suppressed by Treg cells. In this study, we sought to determine the immunological influence of Treg cells during acute FIV infection. We asked whether Treg cell depletion prior to infection with the highly pathogenic molecular clone FIV-C36 in cats could alter FIV pathogenesis. We report here that partial Treg cell depletion prior to FIV infection does not significantly change provirus, viremia, or CD4(+ T cell levels in blood and lymphoid tissues during the acute phase of disease. The effects of anti-CD25 mAb treatment are truncated in cats acutely infected with FIV-C36 as compared to chronically infected cats or FIV-naïve cats, as Treg cell levels were heightened in all treatment groups included in the study within two weeks post-FIV infection. Our findings suggest that the influence of Treg cell suppression during FIV pathogenesis is most prominent after Treg cells are activated in the environment of established FIV infection.

  9. Partial regulatory T cell depletion prior to acute feline immunodeficiency virus infection does not alter disease pathogenesis.

    Science.gov (United States)

    Mikkelsen, S Rochelle; Long, Julie M; Zhang, Lin; Galemore, Erin R; VandeWoude, Sue; Dean, Gregg A

    2011-02-25

    Feline immunodeficiency virus (FIV) infection in cats follows a disease course similar to HIV-1, including a short acute phase characterized by high viremia, and a prolonged asymptomatic phase characterized by low viremia and generalized immune dysfunction. CD4(+)CD25(hi)FoxP3(+) immunosuppressive regulatory T (Treg) cells have been implicated as a possible cause of immune dysfunction during FIV and HIV-1 infection, as they are capable of modulating virus-specific and inflammatory immune responses. Additionally, the immunosuppressive capacity of feline Treg cells has been shown to be increased during FIV infection. We have previously shown that transient in vivo Treg cell depletion during asymptomatic FIV infection reveals FIV-specific immune responses suppressed by Treg cells. In this study, we sought to determine the immunological influence of Treg cells during acute FIV infection. We asked whether Treg cell depletion prior to infection with the highly pathogenic molecular clone FIV-C36 in cats could alter FIV pathogenesis. We report here that partial Treg cell depletion prior to FIV infection does not significantly change provirus, viremia, or CD4(+) T cell levels in blood and lymphoid tissues during the acute phase of disease. The effects of anti-CD25 mAb treatment are truncated in cats acutely infected with FIV-C36 as compared to chronically infected cats or FIV-naïve cats, as Treg cell levels were heightened in all treatment groups included in the study within two weeks post-FIV infection. Our findings suggest that the influence of Treg cell suppression during FIV pathogenesis is most prominent after Treg cells are activated in the environment of established FIV infection.

  10. FijiWings: an open source toolkit for semiautomated morphometric analysis of insect wings.

    Science.gov (United States)

    Dobens, Alexander C; Dobens, Leonard L

    2013-08-07

    Development requires coordination between cell proliferation and cell growth to pattern the proper size of tissues, organs, and whole organisms. The Drosophila wing has landmark features, such as the location of veins patterned by cell groups and trichome structures produced by individual cells, that are useful to examine the genetic contributions to both tissue and cell size. Wing size and trichome density have been measured manually, which is tedious and error prone, and although image processing and pattern-recognition software can quantify features in micrographs, this approach has not been applied to insect wings. Here we present FijiWings, a set of macros designed to perform semiautomated morphophometric analysis of a wing photomicrograph. FijiWings uses plug-ins installed in the Fiji version of ImageJ to detect and count trichomes and measure wing area either to calculate trichome density of a defined region selected by the user or generate a heat map of overall trichome densities. For high-throughput screens we have developed a macro that directs a trainable segmentation plug-in to detect wing vein locations either to measure trichome density in specific intervein regions or produce a heat map of relative intervein areas. We use wing GAL4 drivers and UAS-regulated transgenes to confirm the ability of these tools to detect changes in overall tissue growth and individual cell size. FijiWings is freely available and will be of interest to a broad community of fly geneticists studying both the effect of gene function on wing patterning and the evolution of wing morphology.

  11. T cell subsets in human airways prior to and following endobronchial administration of endotoxin

    DEFF Research Database (Denmark)

    Ronit, Andreas; Plovsing, Ronni R; Gaardbo, Julie C

    2015-01-01

    with peripheral blood. Bronchial LPS induced a local inflammatory response with recruitment of CD4+ (P=0.014), CD8+ T cells (P=0.034), an increase in the proportion of CD4+CD25+CD127lowFoxp3+ regulatory T cells (Tregs) (P=0.045) and a tendency towards an increase in CD4+CD161+ cells (P=0.071) were observed...

  12. Head direction cells in the postsubiculum do not show replay of prior waking sequences during sleep.

    Science.gov (United States)

    Brandon, Mark P; Bogaard, Andrew R; Andrews, Chris M; Hasselmo, Michael E

    2012-03-01

    During slow-wave sleep (SWS) and rapid eye movement (REM) sleep, hippocampal place cells in the rat show replay of sequences previously observed during waking. We tested the hypothesis from computational modeling that the temporal structure of REM sleep replay could arise from an interplay of place cells with head direction cells in the postsubiculum. Physiological single-unit recording was performed simultaneously from five or more head direction or place by head direction cells in the postsubiculum during running on a circular track allowing sampling of a full range of head directions, and during sleep periods before and after running on the circular track. Data analysis compared the spiking activity during individual REM periods with waking as in previous analysis procedures for REM sleep. We also used a new procedure comparing groups of similar runs during waking with REM sleep periods. There was no consistent evidence for a statistically significant correlation of the temporal structure of spiking during REM sleep with spiking during waking running periods. Thus, the spiking activity of head direction cells during REM sleep does not show replay of head direction cell activity occurring during a previous waking period of running on the task. In addition, we compared the spiking of postsubiculum neurons during hippocampal sharp wave ripple events. We show that head direction cells are not activated during sharp wave ripples, whereas neurons responsive to place in the postsubiculum show reliable spiking at ripple events. Copyright © 2011 Wiley Periodicals, Inc.

  13. Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development

    Directory of Open Access Journals (Sweden)

    Matthew A. Inlay

    2014-04-01

    Full Text Available Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability gradually arise. Whereas self-renewal and engraftability have previously been examined in the embryo, multipotency has not been thoroughly addressed, especially at the single-cell level or within well-defined populations. To identify when and where clonal multilineage potential arises during embryogenesis, we developed a single-cell multipotency assay. We find that, during the initiation of definitive hematopoiesis in the embryo, a defined population of multipotent, engraftable progenitors emerges that is much more abundant within the yolk sac (YS than the aorta-gonad-mesonephros (AGM or fetal liver. These experiments indicate that multipotent cells appear in concert within both the YS and AGM and strongly implicate YS-derived progenitors as contributors to definitive hematopoiesis.

  14. Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

    Science.gov (United States)

    Wang, Qian; McPherron, Alexandra C

    2012-01-01

    Muscle fibres are multinucleated post-mitotic cells that can change dramatically in size during adulthood. It has been debated whether muscle fibre hypertrophy requires activation and fusion of muscle stem cells, the satellite cells. Myostatin (MSTN) is a negative regulator of skeletal muscle growth during development and in the adult, and MSTN inhibition is therefore a potential therapy for muscle wasting diseases, some of which are associated with a depletion of satellite cells. Conflicting results have been obtained in previous analyses of the role of MSTN on satellite cell quiescence. Here, we inhibited MSTN in adult mice with a soluble activin receptor type IIB and analysed the incorporation of new nuclei using 5′-bromo-2′-deoxyuridine (BrdU) labelling by isolating individual myofibres. We found that satellite cells are activated by MSTN inhibition. By varying the dose and time course for MSTN inhibition, however, we found that myofibre hypertrophy precedes the incorporation of new nuclei, and that the overall number of new nuclei is relatively low compared to the number of total myonuclei. These results reconcile some of the previous work obtained by other methods. In contrast with previous reports, we also found that Mstn null mice do not have increased satellite cell numbers during adulthood and are not resistant to sarcopaenia. Our results support a previously proposed model of hypertrophy in which hypertrophy can precede satellite cell activation. Studies of the metabolic and functional effects of postnatal MSTN inhibition are needed to determine the consequences of increasing the cytoplasm/myonuclear ratio after MSTN inhibition. PMID:22393251

  15. The Importance of Positive Immunomagnetic Cell Separation Prior to Autologous Hematopoetic Stem Cell Transplantation for Advanced Stage Lymphomas

    Directory of Open Access Journals (Sweden)

    Benedek István

    2016-12-01

    Full Text Available We present the method of immunomagnetic stem cell separation with the ISOLEX 300i device (Isolex® 300i Magnetic Cell Selection System, Nextell Therapeutics Inc. Irvine California 21618 USA and the results obtained using this method in patients admitted to the Hematology and Bone Marrow Transplantation Clinic of Tîrgu Mureş, Romania. Cell selection has a great importance in separating stem cells from tumor cells, therefore contributing to the success of autologous stem cell transplantation.

  16. NO-β-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation.

    Science.gov (United States)

    Ding, Huawen; Keller, Kevin C; Martinez, Ivann K C; Geransar, Rose M; zur Nieden, Kai O; Nishikawa, Sandra G; Rancourt, Derrick E; zur Nieden, Nicole I

    2012-11-15

    Nitric oxide (NO) has been shown to play a crucial role in bone formation in vivo. We sought to determine the temporal effect of NO on murine embryonic stem cells (ESCs) under culture conditions that promote osteogenesis. Expression profiles of NO pathway members and osteoblast-specific markers were analyzed using appropriate assays. We found that NO was supportive of osteogenesis specifically during an early phase of in vitro development (days 3-5). Furthermore, ESCs stably overexpressing the inducible NO synthase showed accelerated and enhanced osteogenesis in vitro and in bone explant cultures. To determine the role of NO in early lineage commitment, a stage in ESC differentiation equivalent to primitive streak formation in vivo, ESCs were transfected with a T-brachyury-GFP reporter. Expression levels of T-brachyury and one of its upstream regulators, β-catenin, the major effector in the canonical Wnt pathway, were responsive to NO levels in differentiating primitive streak-like cells. Our results indicate that NO may be involved in early differentiation through regulation of β-catenin and T-brachyury, controlling the specification of primitive-streak-like cells, which may continue through differentiation to later become osteoblasts.

  17. Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge

    Directory of Open Access Journals (Sweden)

    Leavell Sarah

    2010-05-01

    Full Text Available Abstract Background Several lines of research suggest that exposure to cellular material can alter the susceptibility to infection by HIV-1. Because sexual contact often includes exposure to cellular material, we hypothesized that repeated mucosal exposure to heterologous cells would induce an immune response that would alter the susceptibility to mucosal infection. Using the feline immunodeficiency virus (FIV model of HIV-1 mucosal transmission, the cervicovaginal mucosa was exposed once weekly for 12 weeks to 5,000 heterologous cells or media (control and then cats were vaginally challenged with cell-associated or cell-free FIV. Results Exposure to heterologous cells decreased the percentage of lymphocytes in the mucosal and systemic lymph nodes (LN expressing L-selectin as well as the percentage of CD4+ CD25+ T cells. These shifts were associated with enhanced ex-vivo proliferative responses to heterologous cells. Following mucosal challenge with cell-associated, but not cell-free, FIV, proviral burden was reduced by 64% in cats previously exposed to heterologous cells as compared to media exposed controls. Conclusions The pathogenesis and/or the threshold for mucosal infection by infected cells (but not cell-free virus can be modulated by mucosal exposure to uninfected heterologous cells.

  18. Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation

    International Nuclear Information System (INIS)

    Komaki, Ritsuko; Meyers, Christina A.; Shin, Dong M.; Garden, Adam S.; Byrne, Kevin; Nickens, Judy A.; Cox, James D.

    1995-01-01

    Purpose: Cognitive deficits after treatment for small cell lung cancer (SCLC) have been attributed to prophylactic cranial irradiation (PCI). A prospective study of neuropsychological function was undertaken to document the evolution and magnitude of neuropsychologic deficits. Methods and Materials: Thirty patients with limited stage SCLC who responded well (29 complete response (CR), 1 partial response (PR)) to combination chemotherapy plus thoracic irradiation or resection were studied with neuropsychological tests in the cognitive domains of intelligence, frontal lobe function, language, memory, visual-perception, and motor dexterity prior to a planned course of PCI. Nine patients had a neurologic history that could influence testing. Results: An unexpected 97% (29 out of 30) of patients had evidence of cognitive dysfunction prior to PCI. The most frequent impairment was verbal memory, followed by frontal lobe dysfunction, and fine motor incoordination. Of the patients with no prior neurologic or substance abuse history, 20 out of 21 (95%) had impairments on neuropsychological assessment. This neurologically normal group was just as impaired as the group with such a history with respect to delayed verbal memory and frontal lobe executive function. Eleven patients had neuropsychological testing 6 to 20 months after PCI; no significant differences were found from their pretreatment tests. Conclusions: A high proportion of neurologically normal patients with limited SCLC and favorable responses to combination chemotherapy have specific cognitive deficits before receiving PCI. Short-term (6 to 20 months) observations after PCI have shown no significant deterioration

  19. Autologous blood stem-cell transplantation in patients with advanced Hodgkin's disease and prior radiation to the pelvic site

    International Nuclear Information System (INIS)

    Koerbling, M.H.; Holle, R.; Haas, R.; Knauf, W.; Doerken, B.H.; Ho, A.D.; Kuse, R.; Pralle, H.; Fliedner, T.M.; Hunstein, W.

    1990-01-01

    Patients with relapsed Hodgkin's disease who respond to salvage therapy are successfully treated with cyclophosphamide, carmustine (BCNU), and etoposide (VP-16) (CBV) followed by autologus bone marrow transplantation (ABMT). Because of heavy pretreatment including radiation to the pelvic site, marrow harvest was not feasible in those patients. We therefore used blood-derived hemopoietic precursor cells as an alternative stem-cell source to rescue them after superdose chemotherapy. Hemopoietic precursor cells were mobilized into the peripheral blood either by chemotherapeutic induction of transient myelosuppression followed by an overshooting of blood stem-cell concentration, or by continuous intravenous (IV) granulocyte-macrophage colony-stimulating factor (GM-CSF) administration. The median time to reach 1,000 WBC per microliter, 500 polymorphonuclear cells (PMN) per microliter, or 20,000 platelets per microliter was 10, 20.5, and 38 days, respectively, for 50% of all patients. The platelet counts of two patients never dropped below 20,000/microL following autologous blood stem-cell transplantation (ABSCT), whereas two other patients had to be supported with platelets for 75 and 86 days posttransplant until a stable peripheral platelet count of 20,000/microL was attained. Among the 11 assessable patients, seven are in unmaintained complete remission (CR) at a median follow-up of 318 days. This is a first report on a series of ABSCTs in patients with advanced Hodgkin's disease proving that, despite prior damage to the marrow site, the circulating stem-cell pool is still a sufficient source of hemopoietic precursor cells for stem-cell rescue

  20. T cell maturation stage prior to and during GMP processing informs on CAR T cell expansion in patients

    NARCIS (Netherlands)

    Y. Klaver (Yarne); S.C.L. van Steenbergen; S. Sleijfer (Stefan); J.E.M.A. Debets (Reno); C.H.J. Lamers (Cor)

    2016-01-01

    textabstractAutologous T cells were genetically modified to express a chimeric antigen receptor (CAR) directed toward carboxy-anhydrase-IX (CAIX) and used to treat patients with CAIX-positive metastatic renal cell carcinoma. In this study, we questioned whether the T cell maturation stage in the

  1. Rituximab for lymphoproliferative disease prior to haematopoietic stem cell transplantation for X-linked severe combined immunodeficiency.

    Science.gov (United States)

    Trahair, Toby N; Wainstein, Brynn; Manton, Nicholas; Bourne, Anthony J; Ziegler, John B; Rice, Michael; Russell, Susan J

    2008-02-01

    Lymphoproliferative disease (LPD) is a complication of congenital and acquired immunodeficiency states. There are a number of treatment options for LPD arising after haematopoietic stem cell or solid organ transplantation including reduction of immunosuppression, targeted therapies, such as the anti-CD20 monoclonal antibody, rituximab, and EBV specific cytotoxic lymphocytes. Treatment of LPD in children with congenital immunodeficiency syndromes remains unsatisfactory and is associated with a high mortality rate. We recently managed an infant found to have polymorphic LPD concurrent with X-linked severe combined immunodeficiency (SCID). Haematopoietic stem cell transplantation (HSCT) had to be deferred because of progressive LPD. Treatment with rituximab resulted in regression of the LPD following which the patient received a 5/6 HLA matched umbilical cord blood (UCB) transplant. The patient remains well 20 months following transplantation. Rituximab treatment may have a useful role in the control of LPD associated with congenital immunodeficiency prior to HSCT. (c) 2007 Wiley-Liss, Inc.

  2. An association between newly diagnosed cutaneous T cell lymphoma and prior impetigo: a nested case-control study.

    Science.gov (United States)

    Boursi, Ben; Haynes, Kevin; Mamtani, Ronac; Yang, Yu-Xiao

    2016-11-01

    Colonization with staphylococcus aureus (SA) is associated with disease activity and progression in patients with cutaneous T-cell lymphoma (CTCL) secondary to T-cell activation by bacterial superantigens. The aim of the current study was to evaluate the possible role of SA as an etiologic factor affecting CTCL initiation. We conducted a nested case-control study in a large population-representative database from the UK. Cases were defined as all patients with an incident diagnosis of mycosis fungoides (MF) or Sezary syndrome (SS) between 1995 and 2013. For every case, four eligible controls matched on age, sex, practice-site, and duration of follow-up were selected. Exposure of interest was clinical diagnosis of impetigo prior to CTCL diagnosis. Conditional logistic regression was used to calculate odds-ratio (ORs) and 95 % confidence-interval (CI) for CTCL risk. The results were further stratified according to age, sex and time interval between impetigo and CTCL diagnosis. The study population included 310 cases with MF or SS and 1223 matched controls. Among cases with CTCL 4.8 % (n = 15) had impetigo prior to cancer diagnosis compared to 2 % (n = 24) of controls. The adjusted OR for CTCL diagnosis among patients with prior impetigo was 2.33 (95 % CI 1.12-4.83). The risk was elevated among individuals with impetigo 1-5 years before cancer diagnosis (OR 3.33, 95 % CI 1.00-11.10). There was no change in risk among patients with impetigo more than 5 years before cancer diagnosis (OR 1.09, 95 % CI 0.35-3.37). Our results suggest a possible association between SA colonization and CTCL initiation that might serve as an important etiological factor for the disease.

  3. Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation

    Science.gov (United States)

    Waespe, Nicolas; Van Den Akker, Machiel; Klaassen, Robert J.; Lieberman, Lani; Irwin, Meredith S.; Ali, Salah S.; Abdelhaleem, Mohamed; Zlateska, Bozana; Liebman, Mira; Cada, Michaela; Schechter, Tal; Dror, Yigal

    2016-01-01

    Advanced myelodysplastic syndrome harbors a high risk of progression to acute myeloid leukemia and poor prognosis. In children, there is no established treatment to prevent or delay progression to leukemia prior to hematopoietic stem cell transplantation. Azacitidine is a hypomethylating agent, which was shown to slow progression to leukemia in adults with myelodysplastic syndrome. There is little data on the efficacy of azacitidine in children. We reviewed 22 pediatric patients with advanced myelodysplastic syndrome from a single center, diagnosed between January 2000 and December 2015. Of those, eight patients received off-label azacitidine before hematopoietic stem cell transplantation. A total of 31 cycles were administered and modification or delay occurred in four of them due to cytopenias, infection, nausea/vomiting, and transient renal impairment. Bone marrow blast percentages in azacitidine-treated patients decreased significantly from a median of 15% (range 9–31%) at the start of treatment to 5.5% (0–12%, P=0.02) before hematopoietic stem cell transplantation. Following azacitidine treatment, four patients (50%) achieved marrow remission, and none progressed. In contrast, three untreated patients (21.4%) had progressive disease characterized by >50% increase in blast counts or progression to leukemia. Azacitidine-treated patients had significantly increased 4-year event-free survival (P=0.04); predicted 4-year overall survival was 100% versus 69.3% in untreated patients (P=0.1). In summary, azacitidine treatment prior to hematopoietic stem cell transplantation was well tolerated in pediatric patients with advanced myelodysplastic syndrome, led to partial or complete bone marrow response in seven of eight patients (87.5%), and correlated with superior event-free survival in this cohort. PMID:27540140

  4. Using microbial desalination cells to reduce water salinity prior to reverse osmosis

    KAUST Repository

    Mehanna, Maha

    2010-01-01

    A microbial desalination cell (MDC) is a new method to reduce the salinity of one solution while generating electrical power from organic matter and bacteria in another (anode) solution. Substantial reductions in the salinity can require much larger volumes of the anode solution than the saline water, but any reduction of salinity will benefit the energy efficiency of a downstream reverse osmosis (RO) desalination system. We investigated here the use of an MDC as an RO pre-treatment method using a new type of air-cathode MDC containing three equally sized chambers. A single cycle of operation using a 1 g L -1 acetate solution reduced the conductivity of salt water (5 g L-1 NaCl) by 43 ± 6%, and produced a maximum power density of 480 mW m-2 with a coulombic efficiency of 68 ± 11%. A higher concentration of acetate (2 g L-1) reduced solution conductivity by 60 ± 7%, and a higher salt concentration (20 g L-1 NaCl) reduced solution conductivity by 50 ± 7%. The use of membranes with increased ion exchange capacities further decreased the solution conductivity by 63 ± 2% (20 g L-1 NaCl). These results demonstrate substantial (43-67%) desalination of water is possible using equal volumes of anode solution and salt water. These results show that MDC treatment could be used to substantially reduce salt concentrations and thus energy demands for downstream RO processing, while at the same time producing electrical power. © 2010 The Royal Society of Chemistry.

  5. [Absolute numbers of peripheral blood CD34+ hematopoietic stem cells prior to a leukapheresis procedure as a parameter predicting the efficiency of stem cell collection].

    Science.gov (United States)

    Galtseva, I V; Davydova, Yu O; Gaponova, T V; Kapranov, N M; Kuzmina, L A; Troitskaya, V V; Gribanova, E O; Kravchenko, S K; Mangasarova, Ya K; Zvonkov, E E; Parovichnikova, E N; Mendeleeva, L P; Savchenko, V G

    To identify a parameter predicting a collection of at least 2·106 CD34+ hematopoietic stem cells (HSC)/kg body weight per leukapheresis (LA) procedure. The investigation included 189 patients with hematological malignancies and 3 HSC donors, who underwent mobilization of stem cells with their subsequent collection by LA. Absolute numbers of peripheral blood leukocytes and CD34+ cells before a LA procedure, as well as a number of CD34+ cells/kg body weight (BW) in the LA product stored on the same day were determined in each patient (donor). There was no correlation between the number of leukocytes and that of stored CD34+ cells/kg BW. There was a close correlation between the count of peripheral blood CD34+ cells prior to LA and that of collected CD34+ cells calculated with reference to kg BW. The optimal absolute blood CD34+ cell count was estimated to 20 per µl, at which a LA procedure makes it possible to collect 2·106 or more CD34+ cells/kg BW.

  6. Increased T-cell activation and Th1 cytokine concentrations prior to the diagnosis of B-cell lymphoma in HIV infected patients.

    Science.gov (United States)

    Ouedraogo, David Eric; Makinson, Alain; Kuster, Nils; Nagot, Nicolas; Rubbo, Pierre-Alain; Bollore, Karine; Foulongne, Vincent; Cartron, Guillaume; Olive, Daniel; Reynes, Jacques; Vendrell, Jean-Pierre; Tuaillon, Edouard

    2013-01-01

    Despite the use of combined antiretroviral therapy, HIV-infected individuals have a higher risk of developing B-cell lymphoma compared to the general population. We aim to explore whether lymphocyte activation, increase in Th1 response as well as markers of EBV reactivation, may precede lymphoma diagnosis. Thirteen cases and 26 controls matched on CD4(+) T-cell count and HIV plasma viral load were identified. Samples were collected 0 to 5 years prior to B-cell lymphoma diagnosis. Seven out of 13 (54 %) and 16/26 (61.5 %) of cases and controls were receiving antiretroviral therapy at the time of sampling, respectively. CD8(+) T-cell activation and Th1 cytokine concentrations were measured before lymphoma onset, together with IgG antibodies directed against viral capsid antigen (VCA) and serum levels of EBV DNA. A higher level of CD8(+) T-cell activation was observed in patients developing lymphoma. Four out of seven Th1 cytokine serum concentrations were significantly higher in patients with lymphoma than in the control group: IL-2R, IL-12p40/70, IFN-γ-inducible protein 10 (IP-10) and monokine induced by IFN-γ (MIG). Anti-VCA IgG level were significantly higher in cases than in controls. Four cases (30 %) but no controls had detectable EBV DNA in serum. A higher level of T-cell activation, Th1 cytokine serum concentration and markers of EBV replication, preceded B-cell lymphoma diagnosis. This may suggest that viral antigen stimulation is associated with the genesis of lymphoma in HIV-infected patients.

  7. Ectopic expression of CITED2 prior to reprogramming, promotes and homogenises the conversion of somatic cells into induced pluripotent stem cells.

    Science.gov (United States)

    Charneca, João; Matias, Ana Catarina; Escapa, Ana Luisa; Fernandes, Catarina; Alves, André; Santos, João M A; Nascimento, Rita; Bragança, José

    2017-09-15

    Cited2 plays crucial roles in mouse embryonic stem cells self-renewal, the initiation of the somatic reprogramming process into induced pluripotent stem cells (iPSC) and the suppression of cell senescence. Here, we investigated the potential of CITED2 expression in combination with the Oct4, Sox2, Klf4 and c-Myc factors for reprogramming of primary mouse embryonic fibroblasts (MEF) at passage 2 and 4. The ectopic CITED2 expression in primary MEF prior to the onset of the reprogramming process, generated iPSC with less variability in the expression of endogenous pluripotency-related genes. In contrast, part of the MEF reprogrammed without ectopic expression of CITED2 at passage 4 originated partially reprogrammed iPSC or pre-iPSC. However, the overexpression of CITED2 in the pre-iPSC was insufficient to complete the reprogramming process into iPSC. These results indicated that ectopic CITED2 expression at the onset of the reprogramming process in combination with the reprogramming factors promotes a complete and homogeneous conversion of somatic cells into iPSC. Copyright © 2017. Published by Elsevier Inc.

  8. Utility of ultrasound examination at 10–14 weeks prior to cell-free DNA screening for fetal aneuploidy

    Science.gov (United States)

    VORA, N. L.; ROBINSON, S.; HARDISTY, E. E.; STAMILIO, D. M.

    2017-01-01

    Objective To estimate the frequency of unexpected first-trimester ultrasound findings that would alter prenatal management in pregnant women eligible for cell-free (cf) DNA screening because of advanced maternal age (AMA). Methods This was a retrospective cohort study of all AMA women at a tertiary care center who had a 10–14-week ultrasound examination between 1 January 2012 and 27 April 2015. Information on pregnancy dating, obstetric ultrasound examination, prenatal screening and genetic testing were collected from a perinatal database. The primary outcome was an unexpected ultrasound finding in the first trimester that would alter the prenatal screening/testing strategy. Results In total, 2337 women met the inclusion criteria, with a total of 2462 fetuses. Sixty-eight (2.9%) women had an anomalous fetus, of which 44 (64.7%) had diagnostic testing. In the entire cohort, a non-viable pregnancy was identified in 153 (6.5%) women. Multiple gestation was identified in 32 (1.4%) women; five had a cotwin demise. Gestational dating was revised for 126 (5.4%) women. Among those who opted for aneuploidy screening (n = 1806), 68.5% had cfDNA screening and 31.5% had first-trimester screening by analysis of maternal serum biomarkers and nuchal translucency thickness. Among those eligible for cfDNA screening, 16.1% (95% CI, 15.0–18.0%; 377/2337) had an ultrasound finding (anomaly, incorrect dating, multiple gestation, non-viable pregnancy) at the time of testing that would have altered the provider’s counseling regarding the prenatal screening/testing strategy. Conclusions A substantial proportion of AMA women eligible for cfDNA screening have fetal ultrasound findings that could alter genetic testing strategy and clinical management. This study recommends ultrasound examination prior to cfDNA screening in AMA women. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. PMID:27300317

  9. Utility of ultrasound examination at 10-14 weeks prior to cell-free DNA screening for fetal aneuploidy.

    Science.gov (United States)

    Vora, N L; Robinson, S; Hardisty, E E; Stamilio, D M

    2017-04-01

    To estimate the frequency of unexpected first-trimester ultrasound findings that would alter prenatal management in pregnant women eligible for cell-free (cf) DNA screening because of advanced maternal age (AMA). This was a retrospective cohort study of all AMA women at a tertiary care center who had a 10-14-week ultrasound examination between 1 January 2012 and 27 April 2015. Information on pregnancy dating, obstetric ultrasound examination, prenatal screening and genetic testing were collected from a perinatal database. The primary outcome was an unexpected ultrasound finding in the first trimester that would alter the prenatal screening/testing strategy. In total, 2337 women met the inclusion criteria, with a total of 2462 fetuses. Sixty-eight (2.9%) women had an anomalous fetus, of which 44 (64.7%) had diagnostic testing. In the entire cohort, a non-viable pregnancy was identified in 153 (6.5%) women. Multiple gestation was identified in 32 (1.4%) women; five had a cotwin demise. Gestational dating was revised for 126 (5.4%) women. Among those who opted for aneuploidy screening (n = 1806), 68.5% had cfDNA screening and 31.5% had first-trimester screening by analysis of maternal serum biomarkers and nuchal translucency thickness. Among those eligible for cfDNA screening, 16.1% (95% CI, 15.0-18.0%; 377/2337) had an ultrasound finding (anomaly, incorrect dating, multiple gestation, non-viable pregnancy) at the time of testing that would have altered the provider's counseling regarding the prenatal screening/testing strategy. A substantial proportion of AMA women eligible for cfDNA screening have fetal ultrasound findings that could alter genetic testing strategy and clinical management. This study recommends ultrasound examination prior to cfDNA screening in AMA women. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

  10. Targeted bone marrow irradiation in the conditioning of high-risk leukaemia prior to stem cell transplantation

    International Nuclear Information System (INIS)

    Reske, S.N.; Buchmann, I.; Seitz, U.; Glatting, G.; Neumaier, B.; Kotzerke, J.; Buck, A.; Martin, H.; Bergmann, L.

    2001-01-01

    Disease recurrence following stem cell transplantation (SCT) remains a major problem. Despite the sensitivity of leukaemias to chemotherapy and irradiation, conventional conditioning before SCT is limited by significant organ toxicity. Targeted irradiation of bone marrow and spleen by radioimmunotherapy may provide considerable dose escalation, with limited toxicity to non-target organs. In this study, 27 patients with high-risk or relapsing leukaemia were treated with rhenium-188-labelled CD66a,b,c,e radioimmunoconjugates ( 188 Re-mAb) specific for normal bone marrow in addition to conventional conditioning with high-dose chemotherapy and 12 Gy total body irradiation prior to SCT. A mean activity of 10.2±2.1 (range 6.9-15.8) GBq 188 Re-mAb was administered intravenously. Acute side-effects were assessed according to the CTC classification and patient outcome was determined. Mean radiation doses (Gy; range in parentheses) to relevant organs and whole body were as follows: 13.1 (6.5-22) to bone marrow, 11.6 (1.7-31.1) to spleen, 5.0 (2.0-11.7) to liver, 7.0 (2.3-11.6) to kidneys, 0.7 (0.3-1.3) to lungs and 1.4 (0.8-2.1) to the whole body. Stem cells engrafted in all patients within 9-18 days post SCT. Acute organ toxicity of grade II or less was observed. During follow-up for 25.4±5.3 (range 18-34) months, 4/27 (15%) patients died from relapse, and 9/27 (33%) from transplantation-related complications. Fourteen patients (52%) are still alive and in ongoing complete clinical remission. Radioimmunotherapy with the bone marrow-seeking 188 Re-labelled CD66 mAb can double the dose to bone marrow and spleen without undue extramedullary acute organ toxicity, when given in addition to high-dose chemotherapy and 12 Gy TBI before allogeneic SCT. This intensified conditioning regimen may reduce the relapse rate of high-risk leukaemia. (orig.)

  11. Design and Testing of Aeroelastically Tailored Wings Under Maneuver Loading

    NARCIS (Netherlands)

    Werter, N.P.M.; Sodja, J.; De Breuker, R.

    2016-01-01

    The goal of the present paper is to provide experimental validation data for the aeroelastic analysis of composite aeroelastically tailored wings with a closed-cell cross-sectional structure. Several rectangular wings with differ- ent skin thicknesses and composite layups are designed in order to

  12. Morphing Wing: Experimental Boundary Layer Transition Determination and Wing Vibrations Measurements and Analysis =

    Science.gov (United States)

    Tondji Chendjou, Yvan Wilfried

    This Master's thesis is written within the framework of the multidisciplinary international research project CRIAQ MDO-505. This global project consists of the design, manufacture and testing of a morphing wing box capable of changing the shape of the flexible upper skin of a wing using an actuator system installed inside the wing. This changing of the shape generates a delay in the occurrence of the laminar to turbulent transition area, which results in an improvement of the aerodynamic performances of the morphed wing. This thesis is focused on the technologies used to gather the pressure data during the wind tunnel tests, as well as on the post processing methodologies used to characterize the wing airflow. The vibration measurements of the wing and their real-time graphical representation are also presented. The vibration data acquisition system is detailed, and the vibration data analysis confirms the predictions of the flutter analysis performed on the wing prior to wind tunnel testing at the IAR-NRC. The pressure data was collected using 32 highly-sensitive piezoelectric sensors for sensing the pressure fluctuations up to 10 KHz. These sensors were installed along two wing chords, and were further connected to a National Instrument PXI real-time acquisition system. The acquired pressure data was high-pass filtered, analyzed and visualized using Fast Fourier Transform (FFT) and Standard Deviation (SD) approaches to quantify the pressure fluctuations in the wing airflow, as these allow the detection of the laminar to turbulent transition area. Around 30% of the cases tested in the IAR-NRC wind tunnel were optimized for drag reduction by the morphing wing procedure. The obtained pressure measurements results were compared with results obtained by infrared thermography visualization, and were used to validate the numerical simulations. Two analog accelerometers able to sense dynamic accelerations up to +/-16g were installed in both the wing and the aileron boxes

  13. Immunoaffinity chromatography for the sample pretreatment of Taxus plant and cell extracts prior to analysis of taxanes by high-performance liquid chromatography

    NARCIS (Netherlands)

    Theodoridis, G; Haasnoot, W; Schilt, R; Jaziri, M; Diallo, B; Papadoyannis, IN; de Jong, GJ; Cazemier, G.

    2002-01-01

    The application of immunoaffinity chromatography for the purification of Taxus plant and cell extracts prior to the HPLC analysis is described. Polyclonal antibodies raised against 10-deacetylbaccatin III (10-DAB III), paclitaxel's main precursor in plant, were characterised by enzymed-linked

  14. Basal Complex and Basal Venation of Odonata Wings: Structural Diversity and Potential Role in the Wing Deformation.

    Directory of Open Access Journals (Sweden)

    H Rajabi

    Full Text Available Dragonflies and damselflies, belonging to the order Odonata, are known to be excellent fliers with versatile flight capabilities. The ability to fly over a wide range of speeds, high manoeuvrability and great agility are a few characteristics of their flight. The architecture of the wings and their structural elements have been found to play a major role in this regard. However, the precise influence of individual wing components on the flight performance of these insects remains unknown. The design of the wing basis (so called basal complex and the venation of this part are responsible for particular deformability and specific shape of the wing blade. However, the wing bases are rather different in representatives of different odonate groups. This presumably reflects the dimensions of the wings on one hand, and different flight characteristics on the other hand. In this article, we develop the first three-dimensional (3D finite element (FE models of the proximal part of the wings of typical representatives of five dragonflies and damselflies families. Using a combination of the basic material properties of insect cuticle, a linear elastic material model and a nonlinear geometric analysis, we simulate the mechanical behaviour of the wing bases. The results reveal that although both the basal venation and the basal complex influence the structural stiffness of the wings, it is only the latter which significantly affects their deformation patterns. The use of numerical simulations enabled us to address the role of various wing components such as the arculus, discoidal cell and triangle on the camber formation in flight. Our study further provides a detailed representation of the stress concentration in the models. The numerical analysis presented in this study is not only of importance for understanding structure-function relationship of insect wings, but also might help to improve the design of the wings for biomimetic micro-air vehicles (MAVs.

  15. WINGS Data Release

    DEFF Research Database (Denmark)

    Moretti, A.; Poggianti, B. M.; Fasano, G.

    2014-01-01

    Context. To effectively investigate galaxy formation and evolution, it is of paramount importance to exploit homogeneous data for large samples of galaxies in different environments. Aims. The WIde-field Nearby Galaxy-cluster Survey (WINGS) project aim is to evaluate physical properties of galaxies...... in a complete sample of low redshift clusters to be used as reference sample for evolutionary studies. The WINGS survey is still ongoing and the original dataset will be enlarged with new observations. This paper presents the entire collection of WINGS measurements obtained so far. Methods. We decided to make......, and on the cluster redshift, reaching on average 90% at V ≲ 21.7. Near-infrared photometric catalogs for 26 (in K) and 19 (in J) clusters are part of the database and the number of sources is 962 344 in K and 628 813 in J. Here again the completeness depends on the data quality, but it is on average higher than 90...

  16. WHEN COMPASSION GROWS WINGS

    African Journals Online (AJOL)

    Nicky

    antiretroviral roll-out in full swing, the. WHEN COMPASSION GROWS WINGS. The free time and expertise given by its deeply committed core of professional volunteers. (including pilots) is the lifeblood of the operation. Red Cross Air Mercy Service volunteer, German national Dr Florian Funk, at the AMS Durban base.

  17. Twisted Winged Endoparasitoids

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 10. Twisted Winged Endoparasitoids - An Enigma for Entomologists. Alpana Mazumdar. General Article Volume 9 Issue 10 October 2004 pp 19-24. Fulltext. Click here to view fulltext PDF. Permanent link:

  18. Stable structural color patterns displayed on transparent insect wings.

    Science.gov (United States)

    Shevtsova, Ekaterina; Hansson, Christer; Janzen, Daniel H; Kjærandsen, Jostein

    2011-01-11

    Color patterns play central roles in the behavior of insects, and are important traits for taxonomic studies. Here we report striking and stable structural color patterns--wing interference patterns (WIPs)--in the transparent wings of small Hymenoptera and Diptera, patterns that have been largely overlooked by biologists. These extremely thin wings reflect vivid color patterns caused by thin film interference. The visibility of these patterns is affected by the way the insects display their wings against various backgrounds with different light properties. The specific color sequence displayed lacks pure red and matches the color vision of most insects, strongly suggesting that the biological significance of WIPs lies in visual signaling. Taxon-specific color patterns are formed by uneven membrane thickness, pigmentation, venation, and hair placement. The optically refracted pattern is also stabilized by microstructures of the wing such as membrane corrugations and spherical cell structures that reinforce the pattern and make it essentially noniridescent over a large range of light incidences. WIPs can be applied to map the micromorphology of wings through direct observation and are useful in several fields of biology. We demonstrate their usefulness as identification patterns to solve cases of cryptic species complexes in tiny parasitic wasps, and indicate their potentials for research on the genetic control of wing development through direct links between the transregulatory wing landscape and interference patterns we observe in Drosophila model species. Some species display sexually dimorphic WIPs, suggesting sexual selection as one of the driving forces for their evolution.

  19. Neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to CD4 T-cell expansion, without altering T-cell repertoire.

    Directory of Open Access Journals (Sweden)

    Charlotte F Inman

    Full Text Available Interactions between the early-life colonising intestinal microbiota and the developing immune system are critical in determining the nature of immune responses in later life. Studies in neonatal animals in which this interaction can be examined are central to understanding the mechanisms by which the microbiota impacts on immune development and to developing therapies based on manipulation of the microbiome. The inbred piglet model represents a system that is comparable to human neonates and allows for control of the impact of maternal factors. Here we show that colonisation with a defined microbiota produces expansion of mucosal plasma cells and of T-lymphocytes without altering the repertoire of alpha beta T-cells in the intestine. Importantly, this is preceded by microbially-induced expansion of a signal regulatory protein α-positive (SIRPα(+ antigen-presenting cell subset, whilst SIRPα(-CD11R1(+ antigen-presenting cells (APCs are unaffected by colonisation. The central role of intestinal APCs in the induction and maintenance of mucosal immunity implicates SIRPα(+ antigen-presenting cells as orchestrators of early-life mucosal immune development.

  20. Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation

    NARCIS (Netherlands)

    Wils, Evert-Jan; Braakman, Eric; Verjans, Georges M. G. M.; Rombouts, Elwin J. C.; Broers, Annoek E. C.; Niesters, Hubert G. M.; Wagemaker, Gerard; Staal, Frank J. T.; Lowenberg, Bob; Spits, Hergen; Cornelissen, Jan J.

    2007-01-01

    Deficient thymopoiesis and retarded recovery of newly developed CD4(+) T cells is one of the most important determinants of impaired immunocompetence after hemopoietic stem cell transplantation. Here we evaluated whether Fms-like tyrosine kinase 3 (Flt3) ligand (FL) alone or combined with IL-7

  1. Wing defects in Drosophila xenicid mutant clones are caused by C-terminal deletion of additional sex combs (Asx).

    Science.gov (United States)

    Bischoff, Kara; Ballew, Anna C; Simon, Michael A; O'Reilly, Alana M

    2009-12-01

    The coordinated action of genes that control patterning, cell fate determination, cell size, and cell adhesion is required for proper wing formation in Drosophila. Defects in any of these basic processes can lead to wing aberrations, including blisters. The xenicid mutation was originally identified in a screen designed to uncover regulators of adhesion between wing surfaces [1]. Here, we demonstrate that expression of the betaPS integrin or the patterning protein Engrailed are not affected in developing wing imaginal discs in xenicid mutants. Instead, expression of the homeotic protein Ultrabithorax (Ubx) is strongly increased in xenicid mutant cells. Our results suggest that upregulation of Ubx transforms cells from a wing blade fate to a haltere fate, and that the presence of haltere cells within the wing blade is the primary defect leading to the adult wing phenotypes observed.

  2. Wing defects in Drosophila xenicid mutant clones are caused by C-terminal deletion of additional sex combs (Asx.

    Directory of Open Access Journals (Sweden)

    Kara Bischoff

    2009-12-01

    Full Text Available The coordinated action of genes that control patterning, cell fate determination, cell size, and cell adhesion is required for proper wing formation in Drosophila. Defects in any of these basic processes can lead to wing aberrations, including blisters. The xenicid mutation was originally identified in a screen designed to uncover regulators of adhesion between wing surfaces [1].Here, we demonstrate that expression of the betaPS integrin or the patterning protein Engrailed are not affected in developing wing imaginal discs in xenicid mutants. Instead, expression of the homeotic protein Ultrabithorax (Ubx is strongly increased in xenicid mutant cells.Our results suggest that upregulation of Ubx transforms cells from a wing blade fate to a haltere fate, and that the presence of haltere cells within the wing blade is the primary defect leading to the adult wing phenotypes observed.

  3. INI Expressing Epithelioid Sarcoma with Osteoclastic Giant Cells in a Child: A Case Report with Summary of Prior Published Cases.

    Science.gov (United States)

    Bhattacharyya, Riju; Ghosh, Ranajoy; Saha, Koushik; Chatterjee, Uttara

    2017-08-01

    Epithelioid sarcoma is a heterogeneous tumor with 2 subtypes, classic and proximal. The proximal variant is more aggressive and occurs in proximal location in young adults. We present a proximal epithelioid sarcoma in the leg of an 8 year old girl with rhabdoid morphology and scattered osteoclastic giant cells. Nuclear INI-1 was retained. Despite wide local excision, local recurrence occurred at 8 months. Following re-excision, she developed a chest wall metastasis after 9 months. Epithelioid sarcoma, proximal type with osteoclastic giant cells in the pediatric age group has not been reported previously and should be considered in the differential diagnoses of tumors with epithelioid cell morphology and scattered osteoclastic giant cells. Retained INI expression helped to differentiate this tumor from malignant rhabdoid tumor.

  4. Design optimization of deployable wings

    Science.gov (United States)

    Gaddam, Pradeep

    Morphing technology is an important aspect of UAV design, particularly in regards to deployable systems. The design of such system has an important impact on the vehicle's performance. The primary focus of the present research work was to determine the most optimum deployable wing design from 3 competing designs and develop one of the deployable wing designs to test in the research facility. A Matlab code was developed to optimize 3 deployable wing concepts inflatable, inflatable telescopic and rigid-folding wings based on a sequential optimization strategy. The constraints that were part of the code include the packaging constraints during its stowed state, fixed length of the deployed section and the minimum L/D constraint. This code resulted in determining the optimum weight of all the 3 designs, the most optimum weight design is the inflatable wing design. This is a result of the flexible skin material and also due to no rigid parts in the deployed wing section. Another goal of the research involved developing an inflatable telescopic wing. The prototype was tested in a wind tunnel, while the actual wing was tested in the altitude chamber to determine the deployment speed, input pressure, analyze and predict the deployment sequence and behavior of the wing at such high wind speeds and altitudes ranging from 60,000 ft to 90,000 ft. Results from these tests allowed us to conclude the deployment sequence of the telescopic wing followed from the root to the tip section. The results were used to analyze the deployment time of the wing. As expected the deployment time decreased with an increase in input pressure. The results also show us that as the altitude increases, the deployment speed of the wing also increased. This was demonstrated when the wing was tested at a maximum altitude pressure of 90,000ft, well above the design altitude of 60,000ft.

  5. Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion

    International Nuclear Information System (INIS)

    Roehrig, John T.; Butrapet, Siritorn; Liss, Nathan M.; Bennett, Susan L.; Luy, Betty E.; Childers, Thomas; Boroughs, Karen L.; Stovall, Janae L.; Calvert, Amanda E.; Blair, Carol D.; Huang, Claire Y.-H.

    2013-01-01

    Using an infectious cDNA clone we engineered seven mutations in the putative heparan sulfate- and receptor-binding motifs of the envelope protein of dengue virus serotype 2, strain 16681. Four mutant viruses, KK122/123EE, E202K, G304K, and KKK305/307/310EEE, were recovered following transfection of C6/36 cells. A fifth mutant, KK291/295EE, was recovered from C6/36 cells with a compensatory E295V mutation. All mutants grew in and mediated fusion of virus-infected C6/36 cells, but three of the mutants, KK122/123EE, E202K, G304K, did not grow in Vero cells without further modification. Two Vero cell lethal mutants, KK291/295EV and KKK307/307/310EEE, failed to replicate in DC-SIGN-transformed Raji cells and did not react with monoclonal antibodies known to block DENV attachment to Vero cells. Additionally, both mutants were unable to initiate negative-strand vRNA synthesis in Vero cells by 72 h post-infection, suggesting that the replication block occurred prior to virus-mediated membrane fusion. - Highlights: • Heparan sulfate- and receptor-binding motifs of DENV2 envelope protein were mutated. • Four mutant viruses were isolated—all could fuse C6/36 cells. • Two of these mutants were lethal in Vero cells without further modification. • Lethal mutations were KK291/295EV and KKK305/307/310EEE. • Cell attachment was implicated as the replication block for both mutants

  6. Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion

    Energy Technology Data Exchange (ETDEWEB)

    Roehrig, John T., E-mail: jtr1@cdc.gov [Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521 (United States); Butrapet, Siritorn; Liss, Nathan M. [Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521 (United States); Bennett, Susan L. [Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 (United States); Luy, Betty E.; Childers, Thomas; Boroughs, Karen L.; Stovall, Janae L.; Calvert, Amanda E. [Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521 (United States); Blair, Carol D. [Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 (United States); Huang, Claire Y.-H. [Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521 (United States)

    2013-07-05

    Using an infectious cDNA clone we engineered seven mutations in the putative heparan sulfate- and receptor-binding motifs of the envelope protein of dengue virus serotype 2, strain 16681. Four mutant viruses, KK122/123EE, E202K, G304K, and KKK305/307/310EEE, were recovered following transfection of C6/36 cells. A fifth mutant, KK291/295EE, was recovered from C6/36 cells with a compensatory E295V mutation. All mutants grew in and mediated fusion of virus-infected C6/36 cells, but three of the mutants, KK122/123EE, E202K, G304K, did not grow in Vero cells without further modification. Two Vero cell lethal mutants, KK291/295EV and KKK307/307/310EEE, failed to replicate in DC-SIGN-transformed Raji cells and did not react with monoclonal antibodies known to block DENV attachment to Vero cells. Additionally, both mutants were unable to initiate negative-strand vRNA synthesis in Vero cells by 72 h post-infection, suggesting that the replication block occurred prior to virus-mediated membrane fusion. - Highlights: • Heparan sulfate- and receptor-binding motifs of DENV2 envelope protein were mutated. • Four mutant viruses were isolated—all could fuse C6/36 cells. • Two of these mutants were lethal in Vero cells without further modification. • Lethal mutations were KK291/295EV and KKK305/307/310EEE. • Cell attachment was implicated as the replication block for both mutants.

  7. A potentially critical Hpa II site of the X chromosome-linked PGK1 gene is unmethylated prior to the onset of meiosis of human oogenic cells

    Energy Technology Data Exchange (ETDEWEB)

    Singer-Sam, J.; Dai, A.; Riggs, A.D. (Beckman Research Inst., Duarte, CA (United States)); Goldstein, L.; Gartler, S.M. (Univ. of Washington, Seattle (United States))

    1992-02-15

    Hpa II site H8 is in the CpG-rich 5{prime} untranslated region of the human X chromosome-linked gene for phosphoglycerate kinase 1 (PGK1). It is the only Hpa II site in the CpG island' whose methylation pattern is perfectly correlated with transcriptional silence of this gene. The authors measured DNA methylation at site H8 in fetal oogonia and oocytes and found, using a quantitative assay based on the polymerase chain reaction, that purified germ cells isolated by micromanipulation were unmethylated in 47-day to 110-day fetuses, whereas ovaries depleted of germ cells and non-ovary tissues were methylated. They conclude that site H8 is the unmethylated in germ cells prior to the onset of meiosis and reactivation of the X chromosome.

  8. Low Aspect-Ratio Wings for Wing-Ships

    DEFF Research Database (Denmark)

    Filippone, Antonino; Selig, M.

    1998-01-01

    Flying on ground poses technical and aerodynamical challenges. The requirements for compactness, efficiency, manouverability, off-design operation,open new areas of investigations in the fieldof aerodynamic analysis and design. A review ofthe characteristics of low-aspect ratio wings, in- and out...... of ground, is presented. It is shownthat the performance of such wings is generally inferior to that of slender wings, although in ground placement can yield substantial improvements in the aerodynamic efficiency....

  9. Hemolin expression in the silk glands of Galleria mellonella in response to bacterial challenge and prior to cell disintegration

    Czech Academy of Sciences Publication Activity Database

    Shaik, Haq Abdul; Sehnal, František

    2009-01-01

    Roč. 55, č. 9 (2009), s. 781-787 ISSN 0022-1910 R&D Projects: GA AV ČR IAA5007402 Institutional research plan: CEZ:AV0Z50070508 Keywords : cell recognition * hemolin * 20-hydroxyecdysone Subject RIV: ED - Physiology Impact factor: 2.235, year: 2009

  10. Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus

    International Nuclear Information System (INIS)

    TerWee, Julie A.; Carlson, Jennifer K.; Sprague, Wendy S.; Sondgeroth, Kerry S.; Shropshire, Sarah B.; Troyer, Jennifer L.; VandeWoude, Sue

    2008-01-01

    Immune dysregulation initiated by a profound loss of CD4+ T-cells is fundamental to HIV-induced pathogenesis. Infection of domestic cats with a non-pathogenic lentivirus prevalent in the puma (puma lentivirus, PLV or FIV PCO ) prevented peripheral blood CD4+ T-cell depletion caused by subsequent virulent FIV infection. Maintenance of this critical population was not associated with a significant decrease in FIV viremia, lending support to the hypothesis that direct viral cytopathic effect is not the primary cause of immunodeficiency. Although this approach was analogous to immunization with a modified live vaccine, correlates of immunity such as a serum-neutralizing antibody or virus-specific T-cell proliferative response were not found in protected animals. Differences in cytokine transcription profile, most notably in interferon gamma, were observed between the protected and unprotected groups. These data provide support for the importance of non-adaptive enhancement of the immune response in the prevention of CD4+ T-cell loss

  11. Prior data for non-normal priors.

    Science.gov (United States)

    Greenland, Sander

    2007-08-30

    Data augmentation priors facilitate contextual evaluation of prior distributions and the generation of Bayesian outputs from frequentist software. Previous papers have presented approximate Bayesian methods using 2x2 tables of 'prior data' to represent lognormal relative-risk priors in stratified and regression analyses. The present paper describes extensions that use the tables to represent generalized-F prior distributions for relative risks, which subsume lognormal priors as a limiting case. The method provides a means to increase tail-weight or skew the prior distribution for the log relative risk away from normality, while retaining the simple 2x2 table form of the prior data. When prior normality is preferred, it also provides a more accurate lognormal relative-risk prior in for the 2x2 table format. For more compact representation in regression analyses, the prior data can be compressed into a single data record. The method is illustrated with historical data from a study of electronic foetal monitoring and neonatal death.

  12. Real-time in vivo imaging of butterfly wing development: revealing the cellular dynamics of the pupal wing tissue.

    Directory of Open Access Journals (Sweden)

    Masaki Iwata

    Full Text Available Butterfly wings are covered with regularly arranged single-colored scales that are formed at the pupal stage. Understanding pupal wing development is therefore crucial to understand wing color pattern formation. Here, we successfully employed real-time in vivo imaging techniques to observe pupal hindwing development over time in the blue pansy butterfly, Junonia orithya. A transparent sheet of epithelial cells that were not yet regularly arranged was observed immediately after pupation. Bright-field imaging and autofluorescent imaging revealed free-moving hemocytes and tracheal branches of a crinoid-like structure underneath the epithelium. The wing tissue gradually became gray-white, epithelial cells were arranged regularly, and hemocytes disappeared, except in the bordering lacuna, after which scales grew. The dynamics of the epithelial cells and scale growth were also confirmed by fluorescent imaging. Fluorescent in vivo staining further revealed that these cells harbored many mitochondria at the surface of the epithelium. Organizing centers for the border symmetry system were apparent immediately after pupation, exhibiting a relatively dark optical character following treatment with fluorescent dyes, as well as in autofluorescent images. The wing tissue exhibited slow and low-frequency contraction pulses with a cycle of approximately 10 to 20 minutes, mainly occurring at 2 to 3 days postpupation. The pulses gradually became slower and weaker and eventually stopped. The wing tissue area became larger after contraction, which also coincided with an increase in the autofluorescence intensity that might have been caused by scale growth. Examination of the pattern of color development revealed that the black pigment was first deposited in patches in the central areas of an eyespot black ring and a parafocal element. These results of live in vivo imaging that covered wide wing area for a long time can serve as a foundation for studying the

  13. Purification of Semiconducting Polymer Dots by Size Exclusion Chromatography Prior to Cytotoxicity Assay and Stem Cell Labeling.

    Science.gov (United States)

    Chen, Dandan; Yuan, Ye; Yu, Jiangbo; Chiu, Daniel T; Wu, Changfeng

    2018-03-23

    Semiconducting polymer dots (Pdots) as fluorescent probes have shown promising applications because of their excellent optical properties. However, apparent differences were observed in cytotoxicity assays, which might originate from impurities introduced in polymer synthesis or nanoparticle preparation. In this paper, a simple gel filtration-based purification method was used to address this issue. Purified Pdots displayed obviously decreased cytotoxicity as compared with the same batch of unpurified Pdots. The purified Pdots were further examined in cytotoxicity study on mesenchymal stem cells (MSCs), which are very sensitive to exogenous probes. The results indicated that purified Pdots did not affect the proliferation ability of MSCs, while unpurified Pdots could have obvious cytotoxicity. In addition, the purified Pdots did not show cytotoxicity even after 6-month storage. Our results demonstrated that gel filtration is an effective method for obtaining Pdots with minimal cytotoxicity, which are more suitable for biological applications.

  14. Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing

    Directory of Open Access Journals (Sweden)

    Phillip H Beske

    2015-04-01

    Full Text Available Botulinum neurotoxins (BoNTs are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein cleavage in vitro or monitoring physiological paralysis in vivo. Consequently, the dynamic effects of intoxication on synaptic behaviors are not well understood. We have reported that mouse embryonic stem cell-derived neurons (ESNs are highly sensitive to BoNT based on molecular readouts of intoxication. Here we study the time-dependent changes in synapse- and network-level behaviors following addition of BoNT/A to spontaneously active networks of glutamatergic and GABAergic ESNs. Whole-cell patch-clamp recordings indicated that BoNT/A rapidly blocked synaptic neurotransmission, confirming that ESNs replicate the functional pathophysiology responsible for clinical botulism. Quantitation of spontaneous neurotransmission in pharmacologically isolated synapses revealed accelerated silencing of GABAergic synapses compared to glutamatergic synapses, which was consistent with the selective accumulation of cleaved SNAP-25 at GAD1+ presynaptic terminals at early timepoints. Different latencies of intoxication resulted in complex network responses to BoNT/A addition, involving rapid disinhibition of stochastic firing followed by network silencing. Synaptic activity was found to be highly sensitive to SNAP-25 cleavage, reflecting the functional consequences of the localized cleavage of the small subpopulation of SNAP-25 that is engaged in neurotransmitter release in the nerve terminal. Collectively these findings illustrate that use of synaptic function assays in networked neurons cultures offers a novel and highly sensitive approach for mechanistic studies of toxin:neuron interactions and synaptic responses to BoNT.

  15. Myeloablative radioimmunotherapy in conditioning prior to haematological stem cell transplantation: closing the gap between benefit and toxicity?

    Energy Technology Data Exchange (ETDEWEB)

    Buchmann, Inga; Haberkorn, Uwe [University of Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); University of Luebeck, Luebeck (Germany); Meyer, Ralf G. [University of Mainz, Department of Medicine 3, Mainz (Germany); Mier, Walter [University of Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany)

    2009-03-15

    High-dose radio-/chemotherapy in the context of autologous and allogeneic haematopoietic stem cell transplantation is a double-edged sword. The requirement for dose intensification is linked to an increase in toxicity to noninvolved organs. Particularly for older patients and patients with comorbidities, efficient but toxicity-reduced schemes are needed. Myeloablative radioimmunotherapy is a targeted, internal radiotherapy that uses radiolabelled monoclonal antibodies (mAb) with affinity to the bone marrow. It involves the administration of high radiation doses (up to 30 Gy) to the bone marrow and spleen but without exposing radiosensitive organs to doses higher than 1-7 Gy. Added to conventional or intensity-reduced conditioning, myeloablative radioimmunotherapy may achieve a pronounced antileukaemic effect with tolerable toxicities. A rational and individual design of the ideal nuclide-antibody combination optimizes therapy. The anti-CD33, anti-CD45 and anti-CD66 mAbs appear to be ideal tracers so far. The {beta}-emitter {sup 90}Y is coupled by DTPA and is the best nuclide for myeloablation. Approval trials for DTPA anti-CD66 mAb are underway in Europe, and in the near future these therapies may become applicable in practice. This review gives an overview of current myeloablative conditioning radioimmunotherapy. We discuss the selection of the optimal radioimmunoconjugate and discuss how radioimmunotherapy might be optimized in the future by individualization of therapy protocols. We also highlight the potential advantages of combination therapies. (orig.)

  16. Aeroelastic Wing Shaping Using Distributed Propulsion

    Science.gov (United States)

    Nguyen, Nhan T. (Inventor); Reynolds, Kevin Wayne (Inventor); Ting, Eric B. (Inventor)

    2017-01-01

    An aircraft has wings configured to twist during flight. Inboard and outboard propulsion devices, such as turbofans or other propulsors, are connected to each wing, and are spaced along the wing span. A flight controller independently controls thrust of the inboard and outboard propulsion devices to significantly change flight dynamics, including changing thrust of outboard propulsion devices to twist the wing, and to differentially apply thrust on each wing to change yaw and other aspects of the aircraft during various stages of a flight mission. One or more generators can be positioned upon the wing to provide power for propulsion devices on the same wing, and on an opposite wing.

  17. Stiffness of desiccating insect wings

    Energy Technology Data Exchange (ETDEWEB)

    Mengesha, T E; Vallance, R R [Department of Mechanical Engineering, The George Washington University, 738 Phillips Hall, 801 22nd St NW, Washington, DC 20052 (United States); Mittal, R, E-mail: vallance@gwu.edu [Department of Mechanical Engineering, Johns Hopkins University, 126 Latrobe Hall, 3400 N Charles Street, Baltimore, MD 21218 (United States)

    2011-03-15

    The stiffness of insect wings is typically determined through experimental measurements. Such experiments are performed on wings removed from insects. However, the wings are subject to desiccation which typically leads to an increase in their stiffness. Although this effect of desiccation is well known, a comprehensive study of the rate of change in stiffness of desiccating insect wings would be a significant aid in planning experiments as well as interpreting data from such experiments. This communication presents a comprehensive experimental analysis of the change in mass and stiffness of gradually desiccating forewings of Painted Lady butterflies (Vanessa cardui). Mass and stiffness of the forewings of five butterflies were simultaneously measured every 10 min over a 24 h period. The averaged results show that wing mass declined exponentially by 21.1% over this time period with a time constant of 9.8 h, while wing stiffness increased linearly by 46.2% at a rate of 23.4 {mu}N mm{sup -1} h{sup -1}. For the forewings of a single butterfly, the experiment was performed over a period of 1 week, and the results show that wing mass declined exponentially by 52.2% with a time constant of 30.2 h until it reached a steady-state level of 2.00 mg, while wing stiffness increased exponentially by 90.7% until it reached a steady-state level of 1.70 mN mm{sup -1}. (communication)

  18. Ornithopter Type Flapping Wings for Autonomous Micro Air Vehicles

    Directory of Open Access Journals (Sweden)

    Sutthiphong Srigrarom

    2015-05-01

    Full Text Available In this paper, an ornithopter prototype that mimics the flapping motion of bird flight is developed, and the lift and thrust generation characteristics of different wing designs are evaluated. This project focused on the spar arrangement and material used for the wings that could achieves improved performance. Various lift and thrust measurement techniques are explored and evaluated. Various wings of insects and birds were evaluated to understand how these natural flyers with flapping wings are able to produce sufficient lift to fly. The differences in the flapping aerodynamics were also detailed. Experiments on different wing designs and materials were conducted and a paramount wing was built for a test flight. The first prototype has a length of 46.5 cm, wing span of 88 cm, and weighs 161 g. A mechanism which produced a flapping motion was fabricated and designed to create flapping flight. The flapping flight was produced by using a single motor and a flexible and light wing structure. A force balance made of load cell was then designed to measure the thrust and lift force of the ornithopter. Three sets of wings varying flexibility were fabricated, therefore lift and thrust measurements were acquired from each different set of wings. The lift will be measured in ten cycles computing the average lift and frequency in three different speeds or frequencies (slow, medium and fast. The thrust measurement was measure likewise but in two cycles only. Several observations were made regarding the behavior of flexible flapping wings that should aid in the design of future flexible flapping wing vehicles. The wings angle or phase characteristic were analyze too and studied. The final ornithopter prototype weighs only 160 g, has a wing span of 88.5 cm, that could flap at a maximum flapping frequency of 3.869 Hz, and produce a maximum thrust and lift of about 0.719 and 0.264 N respectively. Next, we proposed resonance type flapping wing utilizes the near

  19. Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Son [Deakin University, Victoria 3216 (Australia); CSIRO Australian Animal Health Laboratory, Victoria 3220 (Australia); Tabarin, Thibault [ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, New South Wales 3220 (Australia); Garvey, Megan; Pade, Corinna [Deakin University, Victoria 3216 (Australia); CSIRO Australian Animal Health Laboratory, Victoria 3220 (Australia); Rossy, Jérémie [ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, New South Wales 3220 (Australia); Monaghan, Paul; Hyatt, Alex [CSIRO Australian Animal Health Laboratory, Victoria 3220 (Australia); Böcking, Till [ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, New South Wales 3220 (Australia); Leis, Andrew [CSIRO Australian Animal Health Laboratory, Victoria 3220 (Australia); Gaus, Katharina, E-mail: k.gaus@unsw.edu.au [ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, New South Wales 3220 (Australia); Mak, Johnson, E-mail: j.mak@deakin.edu.au [Deakin University, Victoria 3216 (Australia); CSIRO Australian Animal Health Laboratory, Victoria 3220 (Australia)

    2015-12-15

    Viruses are often thought to have static structure, and they only remodel after the viruses have entered target cells. Here, we detected a size expansion of virus particles prior to viral entry using cryo-electron microscopy (cryo-EM) and single molecule fluorescence imaging. HIV expanded both under cell-free conditions with soluble receptor CD4 (sCD4) targeting the CD4 binding site on the HIV-1 envelope protein (Env) and when HIV binds to receptor on cellular membrane. We have shown that the HIV Env is needed to facilitate receptor induced virus size expansions, showing that the ‘lynchpin’ for size expansion is highly specific. We demonstrate that the size expansion required maturation of HIV and an internal capsid core with wild type stability, suggesting that different HIV compartments are linked and are involved in remodelling. Our work reveals a previously unknown event in HIV entry, and we propose that this pre-entry priming process enables HIV particles to facilitate the subsequent steps in infection. - Highlights: • Cell free viruses are able to receive external trigger that leads to apparent size expansion. • Virus envelope and CD4 receptor engagement is the lynchpin of virus size expansion. • Internal capsid organisation can influence receptor mediated virus size expansion. • Pre-existing virus-associated lipid membrane in cell free virus can accommodate the receptor mediated virus size expansion.

  20. Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry

    International Nuclear Information System (INIS)

    Pham, Son; Tabarin, Thibault; Garvey, Megan; Pade, Corinna; Rossy, Jérémie; Monaghan, Paul; Hyatt, Alex; Böcking, Till; Leis, Andrew; Gaus, Katharina; Mak, Johnson

    2015-01-01

    Viruses are often thought to have static structure, and they only remodel after the viruses have entered target cells. Here, we detected a size expansion of virus particles prior to viral entry using cryo-electron microscopy (cryo-EM) and single molecule fluorescence imaging. HIV expanded both under cell-free conditions with soluble receptor CD4 (sCD4) targeting the CD4 binding site on the HIV-1 envelope protein (Env) and when HIV binds to receptor on cellular membrane. We have shown that the HIV Env is needed to facilitate receptor induced virus size expansions, showing that the ‘lynchpin’ for size expansion is highly specific. We demonstrate that the size expansion required maturation of HIV and an internal capsid core with wild type stability, suggesting that different HIV compartments are linked and are involved in remodelling. Our work reveals a previously unknown event in HIV entry, and we propose that this pre-entry priming process enables HIV particles to facilitate the subsequent steps in infection. - Highlights: • Cell free viruses are able to receive external trigger that leads to apparent size expansion. • Virus envelope and CD4 receptor engagement is the lynchpin of virus size expansion. • Internal capsid organisation can influence receptor mediated virus size expansion. • Pre-existing virus-associated lipid membrane in cell free virus can accommodate the receptor mediated virus size expansion.

  1. AERODYNAMICS OF WING TIP SAILS

    Directory of Open Access Journals (Sweden)

    MUSHTAK AL-ATABI

    2006-06-01

    Full Text Available Observers have always been fascinated by soaring birds. An interesting feature of these birds is the existence of few feathers extending from the tip of the wing. In this paper, small lifting surfaces were fitted to the tip of a NACA0012 wing in a fashion similar to that of wing tip feathers. Experimental measurements of induced drag, longitudinal static stability and trailing vortex structure were obtained.The tests showed that adding wing tip surfaces (sails decreased the induced drag factor and increased the longitudinal static stability. Results identified two discrete appositely rotated tip vortices and showed the ability of wing tip surfaces to break them down and to diffuse them.

  2. The redder the better: wing color predicts flight performance in monarch butterflies.

    Directory of Open Access Journals (Sweden)

    Andrew K Davis

    Full Text Available The distinctive orange and black wings of monarchs (Danaus plexippus have long been known to advertise their bitter taste and toxicity to potential predators. Recent work also showed that both the orange and black coloration of this species can vary in response to individual-level and environmental factors. Here we examine the relationship between wing color and flight performance in captive-reared monarchs using a tethered flight mill apparatus to quantify butterfly flight speed, duration and distance. In three different experiments (totaling 121 individuals we used image analysis to measure body size and four wing traits among newly-emerged butterflies prior to flight trials: wing area, aspect ratio (length/width, melanism, and orange hue. Results showed that monarchs with darker orange (approaching red wings flew longer distances than those with lighter orange wings in analyses that controlled for sex and other morphometric traits. This finding is consistent with past work showing that among wild monarchs, those sampled during the fall migration are darker in hue (redder than non-migratory monarchs. Together, these results suggest that pigment deposition onto wing scales during metamorphosis could be linked with traits that influence flight, such as thorax muscle size, energy storage or metabolism. Our results reinforce an association between wing color and flight performance in insects that is suggested by past studies of wing melansim and seasonal polyphenism, and provide an important starting point for work focused on mechanistic links between insect movement and color.

  3. The redder the better: wing color predicts flight performance in monarch butterflies.

    Science.gov (United States)

    Davis, Andrew K; Chi, Jean; Bradley, Catherine; Altizer, Sonia

    2012-01-01

    The distinctive orange and black wings of monarchs (Danaus plexippus) have long been known to advertise their bitter taste and toxicity to potential predators. Recent work also showed that both the orange and black coloration of this species can vary in response to individual-level and environmental factors. Here we examine the relationship between wing color and flight performance in captive-reared monarchs using a tethered flight mill apparatus to quantify butterfly flight speed, duration and distance. In three different experiments (totaling 121 individuals) we used image analysis to measure body size and four wing traits among newly-emerged butterflies prior to flight trials: wing area, aspect ratio (length/width), melanism, and orange hue. Results showed that monarchs with darker orange (approaching red) wings flew longer distances than those with lighter orange wings in analyses that controlled for sex and other morphometric traits. This finding is consistent with past work showing that among wild monarchs, those sampled during the fall migration are darker in hue (redder) than non-migratory monarchs. Together, these results suggest that pigment deposition onto wing scales during metamorphosis could be linked with traits that influence flight, such as thorax muscle size, energy storage or metabolism. Our results reinforce an association between wing color and flight performance in insects that is suggested by past studies of wing melansim and seasonal polyphenism, and provide an important starting point for work focused on mechanistic links between insect movement and color.

  4. The Redder the Better: Wing Color Predicts Flight Performance in Monarch Butterflies

    Science.gov (United States)

    Davis, Andrew K.; Chi, Jean; Bradley, Catherine; Altizer, Sonia

    2012-01-01

    The distinctive orange and black wings of monarchs (Danaus plexippus) have long been known to advertise their bitter taste and toxicity to potential predators. Recent work also showed that both the orange and black coloration of this species can vary in response to individual-level and environmental factors. Here we examine the relationship between wing color and flight performance in captive-reared monarchs using a tethered flight mill apparatus to quantify butterfly flight speed, duration and distance. In three different experiments (totaling 121 individuals) we used image analysis to measure body size and four wing traits among newly-emerged butterflies prior to flight trials: wing area, aspect ratio (length/width), melanism, and orange hue. Results showed that monarchs with darker orange (approaching red) wings flew longer distances than those with lighter orange wings in analyses that controlled for sex and other morphometric traits. This finding is consistent with past work showing that among wild monarchs, those sampled during the fall migration are darker in hue (redder) than non-migratory monarchs. Together, these results suggest that pigment deposition onto wing scales during metamorphosis could be linked with traits that influence flight, such as thorax muscle size, energy storage or metabolism. Our results reinforce an association between wing color and flight performance in insects that is suggested by past studies of wing melansim and seasonal polyphenism, and provide an important starting point for work focused on mechanistic links between insect movement and color. PMID:22848463

  5. Relapsed and secondary disease drive the risk profile for invasive aspergillosis prior to stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndrome.

    Science.gov (United States)

    van de Peppel, Robert J; Dekkers, Olaf M; von dem Borne, Peter A; de Boer, Mark G J

    2014-10-01

    Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) are at risk for invasive aspergillosis (IA) even prior to the introduction of stem cell transplantation (SCT). In times of increasing triazole resistance and changing use of antifungal prophylaxis, insight into the risk factors for IA is needed to improve strategies for preventing IA in this population. Consecutive patients who received remission-induction therapy for AML or MDS at the Leiden Academic Medical Centre were included. Instead of standard antifungal prophylaxis, an assertive protocol for diagnosis of suspected fungal infection was in place. IA was classified according to the revised European Organization for Research and Treatment of Cancer criteria. Potential predisposing characteristics for IA were compared by uni- and multivariate analyses. In 45 (25%) of 184 included episodes (167 patients), IA was diagnosed prior to SCT. A multivariate Cox regression model demonstrated that relapsed AML (hazard ratio [HR] 2.4; 95% confidence interval [CI], 1.1-5.1; P = 0.02), secondary AML (HR, 5.2; 95% CI, 2.3-11.8; P < 0.001), and prolonged duration of neutropenia (HR, 2.2; 95% CI, 1.2-4.0; P = 0.01) were independently associated with IA. Use of granulocyte-colony-stimulating factor showed a trend toward a protective effect (HR, 0.37; 95% CI, 0.1-31.0; P = 0.06). Relapsed AML, secondary AML, and duration of neutropenia were independent factors for determining the risk for development of IA prior to SCT. The results provide further guidance for antifungal stewardship programs when integrating individual patient tailored decision making in antifungal prophylaxis strategies. © The Author 2014. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Processing of cell-surface signalling anti-sigma factors prior to signal recognition is a conserved autoproteolytic mechanism that produces two functional domains.

    Science.gov (United States)

    Bastiaansen, Karlijn C; Otero-Asman, Joaquín R; Luirink, Joen; Bitter, Wilbert; Llamas, María A

    2015-09-01

    Cell-surface signalling (CSS) enables Gram-negative bacteria to transduce an environmental signal into a cytosolic response. This regulatory cascade involves an outer membrane receptor that transmits the signal to an anti-sigma factor in the cytoplasmic membrane, allowing the activation of an extracytoplasmic function (ECF) sigma factor. Recent studies have demonstrated that RseP-mediated proteolysis of the anti-sigma factors is key to σ(ECF) activation. Using the Pseudomonas aeruginosa FoxR anti-sigma factor, we show here that RseP is responsible for the generation of an N-terminal tail that likely contains pro-sigma activity. Furthermore, it has been reported previously that this anti-sigma factor is processed in two separate domains prior to signal recognition. Here, we demonstrate that this process is common in these types of proteins and that the processing event is probably due to autoproteolytic activity. The resulting domains interact and function together to transduce the CSS signal. However, our results also indicate that this processing event is not essential for activity. In fact, we have identified functional CSS anti-sigma factors that are not cleaved prior to signal perception. Together, our results indicate that CSS regulation can occur through both complete and initially processed anti-sigma factors. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

  7. Effect of tip vortices on membrane vibration of flexible wings with different aspect ratios

    Directory of Open Access Journals (Sweden)

    Genç Mustafa Serdar

    2016-01-01

    Full Text Available In this study, the effect of the aspect ratio on the aerodynamics characteristic of flexible membrane wings with different aspect ratios (AR = 1 and AR = 3 is experimentally investigated at Reynolds number of 25000. Time accurate measurements of membrane deformation using Digital Image Correlation system (DIC is carried out while normal forces of the wing will be measured by helping a load-cell system and flow on the wing was visualized by means of smoke wire technic. The characteristics of high aspect ratio wings are shown to be affected by leading edge separation bubbles at low Reynolds number. It is concluded that the camber of membrane wing excites the separated shear layer and this situation increases the lift coefficient relatively more as compared to rigid wings. In membrane wings with low aspect ratio, unsteadiness included tip vortices and vortex shedding, and the combination of tip vortices and vortex shedding causes complex unsteady deformations of these membrane wings. The characteristic of high aspect ratio wings was shown to be affected by leading edge separation bubbles at low Reynolds numbers whereas the deformations of flexible wing with low aspect ratio affected by tip vortices and leading edge separation bubbles.

  8. Structural Analysis of a Dragonfly Wing

    NARCIS (Netherlands)

    Jongerius, S.R.; Lentink, D.

    2010-01-01

    Dragonfly wings are highly corrugated, which increases the stiffness and strength of the wing significantly, and results in a lightweight structure with good aerodynamic performance. How insect wings carry aerodynamic and inertial loads, and how the resonant frequency of the flapping wings is tuned

  9. Effect of outer wing separation on lift and thrust generation in a flapping wing system

    International Nuclear Information System (INIS)

    Mahardika, Nanang; Viet, Nguyen Quoc; Park, Hoon Cheol

    2011-01-01

    We explore the implementation of wing feather separation and lead-lagging motion to a flapping wing. A biomimetic flapping wing system with separated outer wings is designed and demonstrated. The artificial wing feather separation is implemented in the biomimetic wing by dividing the wing into inner and outer wings. The features of flapping, lead-lagging, and outer wing separation of the flapping wing system are captured by a high-speed camera for evaluation. The performance of the flapping wing system with separated outer wings is compared to that of a flapping wing system with closed outer wings in terms of forward force and downward force production. For a low flapping frequency ranging from 2.47 to 3.90 Hz, the proposed biomimetic flapping wing system shows a higher thrust and lift generation capability as demonstrated by a series of experiments. For 1.6 V application (lower frequency operation), the flapping wing system with separated wings could generate about 56% higher forward force and about 61% less downward force compared to that with closed wings, which is enough to demonstrate larger thrust and lift production capability of the separated outer wings. The experiments show that the outer parts of the separated wings are able to deform, resulting in a smaller amount of drag production during the upstroke, while still producing relatively greater lift and thrust during the downstroke.

  10. Flapping Wing Micro Air Vehicle Wing Manufacture and Force Testing

    Science.gov (United States)

    2011-03-03

    manufacturing techniques have been developed by various universities for research on Flapping Wing Micro Air Vehicles. Minimal attention though is given...collected at 2kHz (www.polytec.com/psv3d). A 0.25V band-limited white noise input signal is input to a Bogen HTA -125 High Performance Amplifier, which...manufacturing techniques have been developed by various universities for research on Flapping Wing Micro Air Vehicles. Minimal attention though is given

  11. Effect of Sex and Prior Exposure to a Cafeteria Diet on the Distribution of Sex Hormones between Plasma and Blood Cells

    Science.gov (United States)

    Romero, María del Mar; Fernández-López, José Antonio; Remesar, Xavier; Alemany, Marià

    2012-01-01

    It is generally assumed that steroid hormones are carried in the blood free and/or bound to plasma proteins. We investigated whether blood cells were also able to bind/carry sex-related hormones: estrone, estradiol, DHEA and testosterone. Wistar male and female rats were fed a cafeteria diet for 30 days, which induced overweight. The rats were fed the standard rat diet for 15 additional days to minimize the immediate effects of excess ingested energy. Controls were always kept on standard diet. After the rats were killed, their blood was used for 1) measuring plasma hormone levels, 2) determining the binding of labeled hormones to washed red blood cells (RBC), 3) incubating whole blood with labeled hormones and determining the distribution of label between plasma and packed cells, discounting the trapped plasma volume, 4) determining free plasma hormone using labeled hormones, both through membrane ultrafiltration and dextran-charcoal removal. The results were computed individually for each rat. Cells retained up to 32% estrone, and down to 10% of testosterone, with marked differences due to sex and diet (the latter only for estrogens, not for DHEA and testosterone). Sex and diet also affected the concentrations of all hormones, with no significant diet effects for estradiol and DHEA, but with considerable interaction between both factors. Binding to RBC was non-specific for all hormones. Estrogen distribution in plasma compartments was affected by sex and diet. In conclusion: a) there is a large non-specific RBC-carried compartment for estrone, estradiol, DHEA and testosterone deeply affected by sex; b) Prior exposure to a cafeteria (hyperlipidic) diet induced hormone distribution changes, affected by sex, which hint at sex-related structural differences in RBC membranes; c) We postulate that the RBC compartment may contribute to maintain free (i.e., fully active) sex hormone levels in a way similar to plasma proteins non-specific binding. PMID:22479617

  12. Randomized Study of Concurrent Carboplatin, Paclitaxel, and Radiotherapy with or Without Prior Induction Chemotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer

    International Nuclear Information System (INIS)

    Gouda, Y.S.; Eldeeb, N.A.; Omar, A.M.; Kohail, H.M.; El-Geneidy, M.M.; Elkerm, Y.M.

    2006-01-01

    Background: Multiple concepts of combined modality therapy for locally advanced inoperable non-small cell lung cancer have been investigated. These include induction chemotherapy, concomitant chemo-radiotherapy, and radiation only. To date, combined modality therapy specially the use of concomitant chemo-radiotherapy has led to promising results and was shown to be superior to radiotherapy alone in phase II studies. However the optimum chemo-therapeutic regimen to be used as well as the benefit of induction chemotherapy before concomitant chemo-radiotherapy are yet to be determined. Based on these observations, we investigated the use of paclitaxel and carboplatin concomitantly with radiotherapy and the benefit of prior two cycles induction chemotherapy. Materials and Methods: In this trial 50 patients with locally advanced inoperable non small cell lung cancer, good performance status and minimal weight loss have been randomized into 3 groups each of 20 patients. Group A received induction 2 cycles paclitaxel (175 mg/m 2 ) and carboplatin (AUC 6) on day I and 28 th followed by concomitant paclitaxel (45 mg/m 2 ) and carboplatin (AUC 2) weekly with radiotherapy. Group B received concomitant carboplatin, paclitaxel (same doses as in group A) and radiotherapy with no prior induction chemotherapy. Group C received only radiotherapy to a total dose of 60 Gy in conventional fractionation. Results: A total of 60 patients were enrolled in this study between 1998 and 2000. Pretreatment characteristics, including age, gender, performance status, histological features and stage were comparable in each group. The incidence of oesophagi tis was significantly higher in group A and B than in group C (ρ=0.023). Hematological toxicities was also significantly higher in group A and B than in group C (ρ=0.003). The response rate was significantly higher in group A and B than in group C (75%,79%, and 40% respectively) (ρ =0.020). The time to in-field progresion was significantly

  13. Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening

    Directory of Open Access Journals (Sweden)

    John J. O'Leary

    2013-01-01

    Full Text Available Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9 as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant and A2780 (cisplatin-sensitive ovarian carcinoma cell lines were used. The cytotoxic effect of MMP-9/MMP-2 inhibitor, (2R-2-[(4-Biphenylsulfonyl amino]-3 phenylpropionic acid (C21H19NO4S alone or in combination with cisplatin was determined using high content screening. Protein expression was examined using immunohistochemistry and ELISA. Co-incubation of cisplatin and an MMP-9/MMP-2 inhibitor, (2R-2-[(4-Biphenylsulfonyl amino]-3 phenylpropionic acid (C21H19NO4S resulted in significantly greater cytotoxicity as compared to either treatment alone in a cisplatin resistant MMP-9 overexpressing cell line; A2780cis. In addition, pre-incubating with MMP-9i prior to cisplatin further enhances the cytotoxic effect. No significant difference was observed in MMP-9 protein in tissue but a trend towards increased MMP-9 was observed in recurrent serum. We propose that MMP-9/MMP-2i may be utilized in the treatment of recurrent/chemoresistant ovarian cancers that overexpress MMP-9 mRNA but its role in vivo remains to be evaluated.

  14. Research of Morphing Wing Efficiency

    National Research Council Canada - National Science Library

    Komarov, Valery

    2004-01-01

    This report results from a contract tasking Samara State Aerospace University (SSAU) as follows: The contractor will develop and investigate aerodynamic and structural weight theories associated with morphing wing technology...

  15. Drag Performance of Twist Morphing MAV Wing

    Directory of Open Access Journals (Sweden)

    Ismail N.I.

    2016-01-01

    Full Text Available Morphing wing is one of latest evolution found on MAV wing. However, due to few design problems such as limited MAV wing size and complicated morphing mechanism, the understanding of its aerodynamic behaviour was not fully explored. In fact, the basic drag distribution induced by a morphing MAV wing is still remained unknown. Thus, present work is carried out to compare the drag performance between a twist morphing wing with membrane and rigid MAV wing design. A quasi-static aeroelastic analysis by using the Ansys-Fluid Structure Interaction (FSI method is utilized in current works to predict the drag performance a twist morphing MAV wing design. Based on the drag pattern study, the results exhibits that the morphing wing has a partial similarities in overall drag pattern with the baseline (membrane and rigid wing. However, based CD analysis, it shows that TM wing induced higher CD magnitude (between 25% to 82% higher than to the baseline wing. In fact, TM wing also induced the largest CD increment (about 20% to 27% among the wings. The visualization on vortex structure revealed that TM wing also produce larger tip vortex structure (compared to baseline wings which presume to promote higher induce drag component and subsequently induce its higher CD performance.

  16. Outcome of Treatment of Human HeLa Cervical Cancer Cells With Roscovitine Strongly Depends on the Dosage and Cell Cycle Status Prior to the Treatment

    Czech Academy of Sciences Publication Activity Database

    Wesierska-Gadek, J.; Borza, A.; Walzi, E.; Kryštof, Vladimír; Maurer, M.; Komina, O.; Wandl, S.

    2009-01-01

    Roč. 106, č. 5 (2009), s. 937-955 ISSN 0730-2312 Institutional research plan: CEZ:AV0Z50380511 Keywords : APOPTOSIS * CELL CYCLE ARREST * CYCLIN-DEPENDENT KINASES Subject RIV: ED - Physiology Impact factor: 2.935, year: 2009

  17. Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses.

    Directory of Open Access Journals (Sweden)

    Hlumani Ndlovu

    2014-02-01

    Full Text Available IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing an importance for CD28 during the initiation of an immune response against this pathogen. In this study, we used global CD28⁻/⁻ mice and a recently established mouse model that allows for inducible deletion of the cd28 gene by oral administration of tamoxifen (CD28(-/loxCre⁺/⁻+TM to resolve the controversy surrounding the requirement of CD28 costimulation for recall of protective memory responses against pathogenic infections. Following primary infection with N. brasiliensis, CD28⁻/⁻ mice had delayed expulsion of adult worms in the small intestine compared to wild-type C57BL/6 mice that cleared the infection by day 9 post-infection. Delayed expulsion was associated with reduced production of IL-13 and reduced serum levels of antigen specific IgG1 and total IgE. Interestingly, abrogation of CD28 costimulation in CD28(-/loxCre⁺/⁻ mice by oral administration of tamoxifen prior to secondary infection with N. brasiliensis resulted in impaired worm expulsion, similarly to infected CD28⁻/⁻ mice. This was associated with reduced production of the Th2 cytokines IL-13 and IL-4, diminished serum titres of antigen specific IgG1 and total IgE and a reduced CXCR5⁺ T(FH cell population. Furthermore, total number of CD4⁺ T cells and B220⁺ B cells secreting Th1 and Th2 cytokines were significantly reduced in CD28⁻/⁻ mice and tamoxifen treated CD28(-/loxCre⁺/⁻ mice compared to C57BL/6 mice. Importantly, interfering with CD28 costimulatory signalling before re-infection impaired the recruitment and/or expansion of central and effector memory CD4⁺ T cells and follicular B cells to the draining lymph node of tamoxifen treated CD28(-/loxCre⁺/⁻ mice. Therefore, it can be concluded that CD28

  18. Urethral dose sparing in squamous cell carcinoma of anal canal using proton therapy matching electrons with prior brachytherapy for prostate cancer: A case study.

    Science.gov (United States)

    Apinorasethkul, Ontida; Lenards, Nishele; Hunzeker, Ashley

    2016-01-01

    The purpose of this case study is to communicate a technique on treating the re-irradiation of squamous cell carcinoma (SCC) of anal canal with proton fields matched with electron fields to spare prostatic urethra. A 76-year old male presented with a secondary radiation-induced malignancy as a result of prostate brachytherapy seeds irradiation 10 years prior. A rectal examination revealed a bulky tumor at the top of the anal canal involving the left superior-most aspect of the anal canal extending superiorly into the rectum. The inferior extent was palpable approximately 3cm from the anal verge and the superior extent of the mass measured greater than 5cm in the superior-inferior dimension. Chemoradiation was suggested since the patient was opposed to abdominoperineal resection (APR) and colostomy. The use of proton therapy matching with electron fields in the re-irradiation setting could help reduce the complications. A 2 lateral proton beams were designed to treat the bulky tumor volume with 2 electron beams treating the nodal volumes. This complication of treatment fields helped spare the prostatic urethra and reduced the risk of urinary obstruction in the future. Copyright © 2016 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.

  19. Bendamustine-based conditioning prior to autologous stem cell transplantation (ASCT): Results of a French multicenter study of 474 patients from LYmphoma Study Association (LYSA) centers.

    Science.gov (United States)

    Chantepie, Sylvain P; Garciaz, Sylvain; Tchernonog, Emmanuelle; Peyrade, Frederic; Larcher, Marie-Virginie; Diouf, Momar; Fornecker, Luc-Mathieu; Houot, Roch; Gastinne, Thomas; Soussain, Carole; Malak, Sandra; Lemal, Richard; Delette, Caroline; Ibrahim, Ahmad; Gac, Anne-Claire; Reboursière, Emilie; Vilque, Jean-Pierre; Bekadja, Mohamed-Amine; Casasnovas, Rene-Olivier; Gressin, Remy; Guidez, Stéphanie; Coso, Diane; Herbaux, Charles; Yakoub-Agha, Ibrahim; Bouabdallah, Krimo; Durot, Eric; Damaj, Gandhi

    2018-02-23

    Carmustine shortage has led to an increase use of alternative conditioning regimens prior to autologous stem cell transplantation for the treatment of lymphoma, including Bendamustine-based (BeEAM). The aim of this study was to evaluate the safety of the BeEAM regimen in a large cohort of patients. A total of 474 patients with a median age of 56 years were analyzed. The majority of patients had diffuse large B-cell lymphoma (43.5%). Bendamustine was administered at a median dose of 197 mg/m 2 /day (50-250) on days-7 and -6. The observed grade 1-4 toxicities included mucositis (83.5%), gastroenteritis (53%), skin toxicity (34%), colitis (29%), liver toxicity (19%), pneumonitis (5%), and cardiac rhythm disorders (4%). Nonrelapse mortality (NRM) was reported in 3.3% of patients. Acute renal failure (ARF) was reported in 132 cases (27.9%) (G ≥2; 12.3%). Organ toxicities and death were more frequent in patients with post conditioning renal failure. In a multivariate analysis, pretransplant chronic renal failure, bendamustine dose >160 mg/m 2 and age were independent prognostic factors for ARF. Pretransplant chronic renal failure, hyperhydration volume, duration of hyperhydration, and etoposide dose were predictive factors of NRM. A simple, four-point scoring system can stratify patients by levels of risk for ARF and may allow for a reduction in the bendamustine dose to avoid toxicity. Drugs shortage may have dangerous consequences. Prospective, comparative studies are needed to confirm the toxicity/efficacy extents from this conditioning regimen compared to other types of high dose therapy. © 2018 Wiley Periodicals, Inc.

  20. How the pterosaur got its wings.

    Science.gov (United States)

    Tokita, Masayoshi

    2015-11-01

    Throughout the evolutionary history of life, only three vertebrate lineages took to the air by acquiring a body plan suitable for powered flight: birds, bats, and pterosaurs. Because pterosaurs were the earliest vertebrate lineage capable of powered flight and included the largest volant animal in the history of the earth, understanding how they evolved their flight apparatus, the wing, is an important issue in evolutionary biology. Herein, I speculate on the potential basis of pterosaur wing evolution using recent advances in the developmental biology of flying and non-flying vertebrates. The most significant morphological features of pterosaur wings are: (i) a disproportionately elongated fourth finger, and (ii) a wing membrane called the brachiopatagium, which stretches from the posterior surface of the arm and elongated fourth finger to the anterior surface of the leg. At limb-forming stages of pterosaur embryos, the zone of polarizing activity (ZPA) cells, from which the fourth finger eventually differentiates, could up-regulate, restrict, and prolong expression of 5'-located Homeobox D (Hoxd) genes (e.g. Hoxd11, Hoxd12, and Hoxd13) around the ZPA through pterosaur-specific exploitation of sonic hedgehog (SHH) signalling. 5'Hoxd genes could then influence downstream bone morphogenetic protein (BMP) signalling to facilitate chondrocyte proliferation in long bones. Potential expression of Fgf10 and Tbx3 in the primordium of the brachiopatagium formed posterior to the forelimb bud might also facilitate elongation of the phalanges of the fourth finger. To establish the flight-adapted musculoskeletal morphology shared by all volant vertebrates, pterosaurs probably underwent regulatory changes in the expression of genes controlling forelimb and pectoral girdle musculoskeletal development (e.g. Tbx5), as well as certain changes in the mode of cell-cell interactions between muscular and connective tissues in the early phase of their evolution. Developmental data now

  1. Cognitive Temporal Document Priors

    NARCIS (Netherlands)

    Peetz, M.H.; de Rijke, M.

    2013-01-01

    Temporal information retrieval exploits temporal features of document collections and queries. Temporal document priors are used to adjust the score of a document based on its publication time. We consider a class of temporal document priors that is inspired by retention functions considered in

  2. Conceptual Study of Rotary-Wing Microrobotics

    National Research Council Canada - National Science Library

    Chabak, Kelson D

    2008-01-01

    This thesis presents a novel rotary-wing micro-electro-mechanical systems (MEMS) robot design. Two MEMS wing designs were designed, fabricated and tested including one that possesses features conducive to insect level aerodynamics...

  3. Aerodynamic control with passively pitching wings

    Science.gov (United States)

    Gravish, Nick; Wood, Robert

    Flapping wings may pitch passively under aerodynamic and inertial loads. Such passive pitching is observed in flapping wing insect and robot flight. The effect of passive wing pitch on the control dynamics of flapping wing flight are unexplored. Here we demonstrate in simulation and experiment the critical role wing pitching plays in yaw control of a flapping wing robot. We study yaw torque generation by a flapping wing allowed to passively rotate in the pitch axis through a rotational spring. Yaw torque is generated through alternating fast and slow upstroke and and downstroke. Yaw torque sensitively depends on both the rotational spring force law and spring stiffness, and at a critical spring stiffness a bifurcation in the yaw torque control relationship occurs. Simulation and experiment reveal the dynamics of this bifurcation and demonstrate that anomalous yaw torque from passively pitching wings is the result of aerodynamic and inertial coupling between the pitching and stroke-plane dynamics.

  4. Stages III and IV Squamous Cell Carcinoma of the Mouth: Three-Year Experience with Superselective Intraarterial Chemotherapy Using Cisplatin Prior to Definitive Treatment

    International Nuclear Information System (INIS)

    Hirai, Toshinori; Korogi, Yukunori; Hamatake, Satoshi; Nishimura, Ryuichi; Baba, Yuji; Takahashi, Mutsumasa; Uji, Yasuyoshi; Taen, Akira

    1999-01-01

    Purpose: This study was designed to assess the 3-year experience with superselective intraarterial chemotherapy prior to definitive treatment for stages III and IV squamous cell carcinomas of the mouth. Methods: Twenty-two patients prospectively received superselective intraarterial chemotherapy using relatively low-dose cisplatin via a transfemoral approach. The locations of the tumors were the tongue (n= 12), gingiva (n= 5), buccal mucosa (n= 2), hard palate (n= 1), floor of the mouth (n= 1), and lip (n= 1). After intraarterial chemotherapy, 21 patients underwent surgery (n= 14), radiation therapy (n= 6), or both (n= 1). The survival rate of 25 patients who underwent surgery with/without radiation therapy until 1992 at Kumamoto University Hospital was also evaluated as a historical control. The survival curve was calculated with the Kaplan-Meier method, and the statistical difference between survival curves was determined with the generalized Wilcoxon test. Results: The overall response rate was 95% [complete response (tumor completely resolved), 24%; partial response (tumor reduction ≥50%), 71%]. Fifty-two intraarterial infusions were performed without any catheter-related complications. Mild and transient local toxicity such as edema or mucositis of the infused area was relatively common. One patient died of renal failure from cisplatin. After a median follow-up of 20 months (range 2-41 months), the estimated 3-year survival rate for patients who underwent intraarterial chemotherapy plus surgery was 91%. The survival of the patients who underwent intraarterial chemotherapy plus surgery tended to be longer than that of the historical control. Conclusions: Early tumor reduction without delay of subsequent treatments can be obtained by intraarterial chemotherapy while minimizing complications and possibly improving survival. Further investigations of long-term survival with larger series need to be performed

  5. Cellular basis of morphological variation and temperature-related plasticity in Drosophila melanogaster strains with divergent wing shapes.

    Science.gov (United States)

    Torquato, Libéria Souza; Mattos, Daniel; Matta, Bruna Palma; Bitner-Mathé, Blanche Christine

    2014-12-01

    Organ shape evolves through cross-generational changes in developmental patterns at cellular and/or tissue levels that ultimately alter tissue dimensions and final adult proportions. Here, we investigated the cellular basis of an artificially selected divergence in the outline shape of Drosophila melanogaster wings, by comparing flies with elongated or rounded wing shapes but with remarkably similar wing sizes. We also tested whether cellular plasticity in response to developmental temperature was altered by such selection. Results show that variation in cellular traits is associated with wing shape differences, and that cell number may play an important role in wing shape response to selection. Regarding the effects of developmental temperature, a size-related plastic response was observed, in that flies reared at 16 °C developed larger wings with larger and more numerous cells across all intervein regions relative to flies reared at 25 °C. Nevertheless, no conclusive indication of altered phenotypic plasticity was found between selection strains for any wing or cellular trait. We also described how cell area is distributed across different intervein regions. It follows that cell area tends to decrease along the anterior wing compartment and increase along the posterior one. Remarkably, such pattern was observed not only in the selected strains but also in the natural baseline population, suggesting that it might be canalized during development and was not altered by the intense program of artificial selection for divergent wing shapes.

  6. Waving Wing Aerodynamics at Low Reynolds Numbers

    Science.gov (United States)

    2010-07-01

    wing. An attached leading edge vortex has been observed by multiple research groups on both mechanical wing flappers (8; 22; 21; 4) and revolving wing...observed by Ellington et al. (8) in their earlier experiments on the mechanical hawkmoth flapper at Re ≈ 10,000. In these experiments the spanwise flow...on mechanical wing flappers at similar Reynolds numbers, Re ≈ 1,000 and 1,400 respectively. Both sets of experiments revealed a stable attached

  7. Arthur Prior and 'Now'

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Jørgensen, Klaus Frovin

    2016-01-01

    On the 4th of December 1967, Hans Kamp sent his UCLA seminar notes on the logic of ‘now’ to Arthur N. Prior. Kamp’s two-dimensional analysis stimulated Prior to an intense burst of creativity in which he sought to integrate Kamp’s work into tense logic using a one-dimensional approach. Prior...... to a one-dimensional tense logic containing the ‘now’ operator J. Drawing on material from the Prior archive, and the paper “‘Now”’ that detailed Prior’s findings, we retell this story. We focus on Prior’s completeness conjecture for the hybrid system and the role played by temporal reference....

  8. Wing area, wing growth and wing loading of common sandpipers Actitis hypoleucos

    OpenAIRE

    Yalden, Derek; Yalden, D. W.

    2012-01-01

    This study investigates the changes in wing length, area and loading in Common Sandpipers as chicks grow, and as adults add extra mass (during egg-laying or before migration). Common Sandpiper chicks weigh about 17 g and have "hands" that are about 35 mm long at one week old, when the primaries are just emerging from their sheaths. They grow steadily to reach about 40 g, with hands about 85 mm long, at 19 days, when they are just about fledging. Their wings have roughly adult chord width at t...

  9. How Do Wings Generate Lift?

    Indian Academy of Sciences (India)

    Newton's second law of motion. Hence if a wing can generate lift equal to its weight (total weight of the vehicle) it can balance the gravitational pull and can maintain level flight. The equations for fluid flow that are equivalent to the second law are the well- known Navier–Stokes (N–S) equations [1]. These equations have.

  10. Werner helicase wings DNA binding

    OpenAIRE

    Hoadley, Kelly A.; Keck, James L.

    2010-01-01

    In this issue of Structure, Kitano et al. describe the structure of the DNA-bound winged-helix domain from the Werner helicase. This structure of a RecQ/DNA complex offers insights into the DNA unwinding mechanisms of RecQ family helicases.

  11. On Wings: Aerodynamics of Eagles.

    Science.gov (United States)

    Millson, David

    2000-01-01

    The Aerodynamics Wing Curriculum is a high school program that combines basic physics, aerodynamics, pre-engineering, 3D visualization, computer-assisted drafting, computer-assisted manufacturing, production, reengineering, and success in a 15-hour, 3-week classroom module. (JOW)

  12. Probabilistic Structural Health Monitoring of the Orbiter Wing Leading Edge

    Science.gov (United States)

    Yap, Keng C.; Macias, Jesus; Kaouk, Mohamed; Gafka, Tammy L.; Kerr, Justin H.

    2011-01-01

    A structural health monitoring (SHM) system can contribute to the risk management of a structure operating under hazardous conditions. An example is the Wing Leading Edge Impact Detection System (WLEIDS) that monitors the debris hazards to the Space Shuttle Orbiter s Reinforced Carbon-Carbon (RCC) panels. Since Return-to-Flight (RTF) after the Columbia accident, WLEIDS was developed and subsequently deployed on board the Orbiter to detect ascent and on-orbit debris impacts, so as to support the assessment of wing leading edge structural integrity prior to Orbiter re-entry. As SHM is inherently an inverse problem, the analyses involved, including those performed for WLEIDS, tend to be associated with significant uncertainty. The use of probabilistic approaches to handle the uncertainty has resulted in the successful implementation of many development and application milestones.

  13. Residual strength and crack propagation tests on C-130 airplane center wings with service-imposed fatigue damage

    Science.gov (United States)

    Snider, H. L.; Reeder, F. L.; Dirkin, W. J.

    1972-01-01

    Fourteen C-130 airplane center wings, each containing service-imposed fatigue damage resulting from 4000 to 13,000 accumulated flight hours, were tested to determine their fatigue crack propagation and static residual strength characteristics. Eight wings were subjected to a two-step constant amplitude fatigue test prior to static testing. Cracks up to 30 inches long were generated in these tests. Residual static strengths of these wings ranged from 56 to 87 percent of limit load. The remaining six wings containing cracks up to 4 inches long were statically tested as received from field service. Residual static strengths of these wings ranged from 98 to 117 percent of limit load. Damage-tolerant structural design features such as fastener holes, stringers, doublers around door cutouts, and spanwise panel splices proved to be effective in retarding crack propagation.

  14. Review Results on Wing-Body Interference

    Directory of Open Access Journals (Sweden)

    Frolov Vladimir

    2016-01-01

    Full Text Available The paper presents an overview of results for wing-body interference, obtained by the author for varied wing-body combinations. The lift-curve slopes of the wing-body combinations are considered. In this paper a discrete vortices method (DVM and 2D potential model for cross-flow around fuselage are used. The circular and elliptical cross-sections of the fuselage and flat wings of various forms are considered. Calculations showed that the value of the lift-curve slopes of the wing-body combinations may exceed the same value for an isolated wing. This result confirms an experimental data obtained by other authors earlier. Within a framework of the used mathematical models the investigations to optimize the wing-body combination were carried. The present results of the optimization problem for the wing-body combination allowed to select the optimal geometric characteristics for configuration to maximize the values of the lift-curve slopes of the wing-body combination. It was revealed that maximums of the lift-curve slopes for the optimal mid-wing configuration with elliptical cross-section body had a sufficiently large relative width of the body (more than 30% of the span wing.

  15. Decontamination of hot cells K-1, K-3, M-1, M-3, and A-1, M-Wing, Building 200: Project final report Argonne National Laboratory-East

    Energy Technology Data Exchange (ETDEWEB)

    Cheever, C.L.; Rose, R.W.

    1996-09-01

    The purpose of this project was to remove radioactively contaminated materials and equipment from the hot cells, to decontaminate the hot cells, and to dispose of the radioactive waste. The goal was to reduce stack releases of Rn-220 and to place the hot cells in an emptied, decontaminated condition with less than 10 {micro}Sv/h (1 mrem/h) general radiation background. The following actions were needed: organize and mobilize a decontamination team; prepare decontamination plans and procedures; perform safety analyses to ensure protection of the workers, public, and environment; remotely size-reduce, package, and remove radioactive materials and equipment for waste disposal; remotely decontaminate surfaces to reduce hot cell radiation background levels to allow personnel entries using supplied air and full protective suits; disassemble and package the remaining radioactive materials and equipment using hands-on techniques; decontaminate hot cell surfaces to remove loose radioactive contaminants and to attain a less than 10 {micro}Sv/h (1 mrem/h) general background level; document and dispose of the radioactive and mixed waste; and conduct a final radiological survey.

  16. Decontamination of hot cells K-1, K-3, M-1, M-3, and A-1, M-Wing, Building 200: Project final report Argonne National Laboratory-East

    International Nuclear Information System (INIS)

    Cheever, C.L.; Rose, R.W.

    1996-09-01

    The purpose of this project was to remove radioactively contaminated materials and equipment from the hot cells, to decontaminate the hot cells, and to dispose of the radioactive waste. The goal was to reduce stack releases of Rn-220 and to place the hot cells in an emptied, decontaminated condition with less than 10 microSv/h (1 mrem/h) general radiation background. The following actions were needed: organize and mobilize a decontamination team; prepare decontamination plans and procedures; perform safety analyses to ensure protection of the workers, public, and environment; remotely size-reduce, package, and remove radioactive materials and equipment for waste disposal; remotely decontaminate surfaces to reduce hot cell radiation background levels to allow personnel entries using supplied air and full protective suits; disassemble and package the remaining radioactive materials and equipment using hands-on techniques; decontaminate hot cell surfaces to remove loose radioactive contaminants and to attain a less than 10 microSv/h (1 mrem/h) general background level; document and dispose of the radioactive and mixed waste; and conduct a final radiological survey

  17. A Drosophila wing spot test

    International Nuclear Information System (INIS)

    Ayaki, Toshikazu; Yoshikawa, Isao; Niikawa, Norio; Hoshi, Masaharu.

    1986-01-01

    A Drosophila wing spot test system was used to investigate the effects of low doses of X-rays, gamma rays, and both 2.3 and 14.1 MeV neutrons on somatic chromosome mutation (SCM) induction. The incidence of SCM was significantly increased with any type of radiation, with evident linear dose-response relationship within the range of 3 to 20 cGy. It was estimated that relative biological effectiveness value for SCM induction of 2.3 MeV neutrons to X-rays and gamma rays is much higher than that of 14.1 MeV neutrons to those photons (2.4 vs 8.0). The Drosophila wing spot test system seems to become a promising in vivo experimental method for higher animals in terms of the lack of necessity for a marvelously large number of materials required in conventional test system. (Namekawa, K.)

  18. Aerodynamic effects of flexibility in flapping wings

    Science.gov (United States)

    Zhao, Liang; Huang, Qingfeng; Deng, Xinyan; Sane, Sanjay P.

    2010-01-01

    Recent work on the aerodynamics of flapping flight reveals fundamental differences in the mechanisms of aerodynamic force generation between fixed and flapping wings. When fixed wings translate at high angles of attack, they periodically generate and shed leading and trailing edge vortices as reflected in their fluctuating aerodynamic force traces and associated flow visualization. In contrast, wings flapping at high angles of attack generate stable leading edge vorticity, which persists throughout the duration of the stroke and enhances mean aerodynamic forces. Here, we show that aerodynamic forces can be controlled by altering the trailing edge flexibility of a flapping wing. We used a dynamically scaled mechanical model of flapping flight (Re ≈ 2000) to measure the aerodynamic forces on flapping wings of variable flexural stiffness (EI). For low to medium angles of attack, as flexibility of the wing increases, its ability to generate aerodynamic forces decreases monotonically but its lift-to-drag ratios remain approximately constant. The instantaneous force traces reveal no major differences in the underlying modes of force generation for flexible and rigid wings, but the magnitude of force, the angle of net force vector and centre of pressure all vary systematically with wing flexibility. Even a rudimentary framework of wing veins is sufficient to restore the ability of flexible wings to generate forces at near-rigid values. Thus, the magnitude of force generation can be controlled by modulating the trailing edge flexibility and thereby controlling the magnitude of the leading edge vorticity. To characterize this, we have generated a detailed database of aerodynamic forces as a function of several variables including material properties, kinematics, aerodynamic forces and centre of pressure, which can also be used to help validate computational models of aeroelastic flapping wings. These experiments will also be useful for wing design for small robotic

  19. Aerodynamic effects of flexibility in flapping wings.

    Science.gov (United States)

    Zhao, Liang; Huang, Qingfeng; Deng, Xinyan; Sane, Sanjay P

    2010-03-06

    Recent work on the aerodynamics of flapping flight reveals fundamental differences in the mechanisms of aerodynamic force generation between fixed and flapping wings. When fixed wings translate at high angles of attack, they periodically generate and shed leading and trailing edge vortices as reflected in their fluctuating aerodynamic force traces and associated flow visualization. In contrast, wings flapping at high angles of attack generate stable leading edge vorticity, which persists throughout the duration of the stroke and enhances mean aerodynamic forces. Here, we show that aerodynamic forces can be controlled by altering the trailing edge flexibility of a flapping wing. We used a dynamically scaled mechanical model of flapping flight (Re approximately 2000) to measure the aerodynamic forces on flapping wings of variable flexural stiffness (EI). For low to medium angles of attack, as flexibility of the wing increases, its ability to generate aerodynamic forces decreases monotonically but its lift-to-drag ratios remain approximately constant. The instantaneous force traces reveal no major differences in the underlying modes of force generation for flexible and rigid wings, but the magnitude of force, the angle of net force vector and centre of pressure all vary systematically with wing flexibility. Even a rudimentary framework of wing veins is sufficient to restore the ability of flexible wings to generate forces at near-rigid values. Thus, the magnitude of force generation can be controlled by modulating the trailing edge flexibility and thereby controlling the magnitude of the leading edge vorticity. To characterize this, we have generated a detailed database of aerodynamic forces as a function of several variables including material properties, kinematics, aerodynamic forces and centre of pressure, which can also be used to help validate computational models of aeroelastic flapping wings. These experiments will also be useful for wing design for small

  20. An insect-inspired flapping wing micro air vehicle with double wing clap-fling effects and capability of sustained hovering

    Science.gov (United States)

    Nguyen, Quoc-Viet; Chan, Woei Leong; Debiasi, Marco

    2015-03-01

    We present our recent flying insect-inspired Flapping-Wing Micro Air Vehicle (FW-MAV) capable of hovering flight which we have recently achieved. The FW-MAV has wing span of 22 cm (wing tip-to-wing tip), weighs about 16.6 grams with onboard integration of radio control system including a radio receiver, an electronic speed control (ESC) for brushless motor, three servos for attitude flight controls of roll, pitch, and yaw, and a single cell lithium-polymer (LiPo) battery (3.7 V). The proposed gear box enables the FW-MAV to use one DC brushless motor to synchronously drive four wings and take advantage of the double clap-and-fling effects during one flapping cycle. Moreover, passive wing rotation is utilized to simplify the design, in addition to passive stabilizing surfaces for flight stability. Powered by a single cell LiPo battery (3.7 V), the FW-MAV flaps at 13.7 Hz and produces an average vertical force or thrust of about 28 grams, which is sufficient for take-off and hovering flight. Finally, free flight tests in terms of vertical take-off, hovering, and manual attitude control flight have been conducted to verify the performance of the FW-MAV.

  1. Effects of wing locations on wing rock induced by forebody vortices

    Directory of Open Access Journals (Sweden)

    Ma Baofeng

    2016-10-01

    Full Text Available Previous studies have shown that asymmetric vortex wakes over slender bodies exhibit a multi-vortex structure with an alternate arrangement along a body axis at high angle of attack. In this investigation, the effects of wing locations along a body axis on wing rock induced by forebody vortices was studied experimentally at a subcritical Reynolds number based on a body diameter. An artificial perturbation was added onto the nose tip to fix the orientations of forebody vortices. Particle image velocimetry was used to identify flow patterns of forebody vortices in static situations, and time histories of wing rock were obtained using a free-to-roll rig. The results show that the wing locations can affect significantly the motion patterns of wing rock owing to the variation of multi-vortex patterns of forebody vortices. As the wing locations make the forebody vortices a two-vortex pattern, the wing body exhibits regularly divergence and fixed-point motion with azimuthal variations of the tip perturbation. If a three-vortex pattern exists over the wing, however, the wing-rock patterns depend on the impact of the highest vortex and newborn vortex. As the three vortices together influence the wing flow, wing-rock patterns exhibit regularly fixed-points and limit-cycled oscillations. With the wing moving backwards, the newborn vortex becomes stronger, and wing-rock patterns become fixed-points, chaotic oscillations, and limit-cycled oscillations. With further backward movement of wings, the vortices are far away from the upper surface of wings, and the motions exhibit divergence, limit-cycled oscillations and fixed-points. For the rearmost location of the wing, the wing body exhibits stochastic oscillations and fixed-points.

  2. Artificial insect wings of diverse morphology for flapping-wing micro air vehicles

    International Nuclear Information System (INIS)

    Shang, J K; Finio, B M; Wood, R J; Combes, S A

    2009-01-01

    The development of flapping-wing micro air vehicles (MAVs) demands a systematic exploration of the available design space to identify ways in which the unsteady mechanisms governing flapping-wing flight can best be utilized for producing optimal thrust or maneuverability. Mimicking the wing kinematics of biological flight requires examining the potential effects of wing morphology on flight performance, as wings may be specially adapted for flapping flight. For example, insect wings passively deform during flight, leading to instantaneous and potentially unpredictable changes in aerodynamic behavior. Previous studies have postulated various explanations for insect wing complexity, but there lacks a systematic approach for experimentally examining the functional significance of components of wing morphology, and for determining whether or not natural design principles can or should be used for MAVs. In this work, a novel fabrication process to create centimeter-scale wings of great complexity is introduced; via this process, a wing can be fabricated with a large range of desired mechanical and geometric characteristics. We demonstrate the versatility of the process through the creation of planar, insect-like wings with biomimetic venation patterns that approximate the mechanical properties of their natural counterparts under static loads. This process will provide a platform for studies investigating the effects of wing morphology on flight dynamics, which may lead to the design of highly maneuverable and efficient MAVs and insight into the functional morphology of natural wings.

  3. Timed Knickkopf function is essential for wing cuticle formation in Drosophila melanogaster.

    Science.gov (United States)

    Li, Kaixia; Zhang, Xubo; Zuo, Ying; Liu, Weimin; Zhang, Jianzhen; Moussian, Bernard

    2017-10-01

    The insect cuticle is an extracellular matrix that consists of the polysaccharide chitin, proteins, lipids and organic molecules that are arranged in distinct horizontal layers. In Drosophila melanogaster, these layers are not formed sequentially, but, at least partially, at the same time. Timing of the underlying molecular mechanisms is conceivably crucial for cuticle formation. To study this issue, we determined the time period during which the function of Knickkopf (Knk), a key factor of chitin organization, is required for wing cuticle differentiation in D. melanogaster. Although knk is expressed throughout metamorphosis, we demonstrate that its expression 30 h prior and 48 h after pupariation is essential for correct wing cuticle formation. In other words, expression beyond this period is futile. Importantly, manipulation of Knk expression during this time causes wing bending suggesting an effect of Knk amounts on the physical properties of the wing cuticle. Manipulation of Knk expression also interferes with the structure and function of the cuticle surface. First, we show that the shape of surface nano-structures depends on the expression levels of knk. Second, we find that cuticle impermeability is compromised in wings with reduced knk expression. In summary, despite the extended supply of Knk during metamorphosis, controlled amounts of Knk are important for correct wing cuticle differentiation and function in a concise period of time. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Role of wing morphing in thrust generation

    Directory of Open Access Journals (Sweden)

    Mehdi Ghommem

    2014-01-01

    Full Text Available In this paper, we investigate the role of morphing on flight dynamics of two birds by simulating the flow over rigid and morphing wings that have the characteristics of two different birds, namely the Giant Petrel and Dove Prion. The simulation of a flapping rigid wing shows that the root of the wing should be placed at a specific angle of attack in order to generate enough lift to balance the weight of the bird. However, in this case the generated thrust is either very small, or even negative, depending on the wing shape. Further, results show that morphing of the wing enables a significant increase in the thrust and propulsive efficiency. This indicates that the birds actually utilize some sort of active wing twisting and bending to produce enough thrust. This study should facilitate better guidance for the design of flapping air vehicles.

  5. A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen

    OpenAIRE

    LEE, YU-CHIN; HO, CHING-LIANG; KAO, WOEI-YAU; CHEN, YUH-MIN

    2015-01-01

    Antroquinonol is isolated from Antrodia camphorata, a camphor tree mushroom, and is a valuable traditional Chinese herbal medicine that exhibits pharmacological activities against several diseases, including cancer. This first-in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer who had received at least two prior systemic treatment regimens. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolera...

  6. Analysis of bat wings for morphing

    Science.gov (United States)

    Leylek, Emily A.; Manzo, Justin E.; Garcia, Ephrahim

    2008-03-01

    The morphing of wings from three different bat species is studied using an extension of the Weissinger method. To understand how camber affects performance factors such as lift and lift to drag ratio, XFOIL is used to study thin (3% thickness to chord ratio) airfoils at a low Reynolds number of 100,000. The maximum camber of 9% yielded the largest lift coefficient, and a mid-range camber of 7% yielded the largest lift to drag ratio. Correlations between bat wing morphology and flight characteristics are covered, and the three bat wing planforms chosen represent various combinations of morphological components and different flight modes. The wings are studied using the extended Weissinger method in an "unmorphed" configuration using a thin, symmetric airfoil across the span of the wing through angles of attack of 0°-15°. The wings are then run in the Weissinger method at angles of attack of -2° to 12° in a "morphed" configuration modeled after bat wings seen in flight, where the camber of the airfoils comprising the wings is varied along the span and a twist distribution along the span is introduced. The morphed wing configurations increase the lift coefficient over 1000% from the unmorphed configuration and increase the lift to drag ratio over 175%. The results of the three different species correlate well with their flight in nature.

  7. Veins improve fracture toughness of insect wings.

    Directory of Open Access Journals (Sweden)

    Jan-Henning Dirks

    Full Text Available During the lifetime of a flying insect, its wings are subjected to mechanical forces and deformations for millions of cycles. Defects in the micrometre thin membranes or veins may reduce the insect's flight performance. How do insects prevent crack related material failure in their wings and what role does the characteristic vein pattern play? Fracture toughness is a parameter, which characterises a material's resistance to crack propagation. Our results show that, compared to other body parts, the hind wing membrane of the migratory locust S. gregaria itself is not exceptionally tough (1.04±0.25 MPa√m. However, the cross veins increase the wing's toughness by 50% by acting as barriers to crack propagation. Using fracture mechanics, we show that the morphological spacing of most wing veins matches the critical crack length of the material (1132 µm. This finding directly demonstrates how the biomechanical properties and the morphology of locust wings are functionally correlated in locusts, providing a mechanically 'optimal' solution with high toughness and low weight. The vein pattern found in insect wings thus might inspire the design of more durable and lightweight artificial 'venous' wings for micro-air-vehicles. Using the vein spacing as indicator, our approach might also provide a basis to estimate the wing properties of endangered or extinct insect species.

  8. Exploring the Role of Habitat on the Wettability of Cicada Wings.

    Science.gov (United States)

    Oh, Junho; Dana, Catherine E; Hong, Sungmin; Román, Jessica K; Jo, Kyoo Dong; Hong, Je Won; Nguyen, Jonah; Cropek, Donald M; Alleyne, Marianne; Miljkovic, Nenad

    2017-08-16

    Evolutionary pressure has pushed many extant species to develop micro/nanostructures that can significantly affect wettability and enable functionalities such as droplet jumping, self-cleaning, antifogging, antimicrobial, and antireflectivity. In particular, significant effort is underway to understand the insect wing surface structure to establish rational design tools for the development of novel engineered materials. Most studies, however, have focused on superhydrophobic wings obtained from a single insect species, in particular, the Psaltoda claripennis cicada. Here, we investigate the relationship between the spatially dependent wing wettability, topology, and droplet jumping behavior of multiple cicada species and their habitat, lifecycle, and interspecies relatedness. We focus on cicada wings of four different species: Neotibicen pruinosus, N. tibicen, Megatibicen dorsatus, and Magicicada septendecim and take a comparative approach. Using spatially resolved microgoniometry, scanning electron microscopy, atomic force microscopy, and high speed optical microscopy, we show that within cicada species, the wettability of wings is spatially homogeneous across wing cells. All four species were shown to have truncated conical pillars with widely varying length scales ranging from 50 to 400 nm in height. Comparison of the wettability revealed three cicada species with wings that are superhydrophobic (>150°) with low contact angle hysteresis (water shedding behavior but also enables the development of rational design tools for the manufacture of artificial surfaces for energy and water applications.

  9. Quad-thopter: Tailless Flapping Wing Robot with 4 Pairs of Wings

    NARCIS (Netherlands)

    de Wagter, C.; Karasek, M.; de Croon, G.C.H.E.; J.-M. Moschetta G. Hattenberger, H. de Plinval

    2017-01-01

    We present a novel design of a tailless flapping wing Micro Air Vehicle (MAV), which uses four independently driven pairs of flapping wings in order to fly and perform agile maneuvers. The wing pairs are arranged such that differential thrust generates the desired roll and pitch moments, similar to

  10. Adaptive wing : Investigations of passive wing technologies for loads reduction in the cleansky smart fixed wing aircraft (SFWA) project

    NARCIS (Netherlands)

    Kruger, W.R.; Dillinger, J; De Breuker, R.; Reyes, M.; Haydn, K.

    2016-01-01

    In the work package “Adaptive Wing” in the Clean-Sky “Smart Fixed Wing Aircraft” (SFWA) project, design processes and solutions for aircraft wings have been created, giving optimal response with respect to loads, comfort and performance by the introduction of passive and active concepts. Central

  11. Prior indigenous technological species

    Science.gov (United States)

    Wright, Jason T.

    2018-01-01

    One of the primary open questions of astrobiology is whether there is extant or extinct life elsewhere the solar system. Implicit in much of this work is that we are looking for microbial or, at best, unintelligent life, even though technological artefacts might be much easier to find. Search for Extraterrestrial Intelligence (SETI) work on searches for alien artefacts in the solar system typically presumes that such artefacts would be of extrasolar origin, even though life is known to have existed in the solar system, on Earth, for eons. But if a prior technological, perhaps spacefaring, species ever arose in the solar system, it might have produced artefacts or other technosignatures that have survived to present day, meaning solar system artefact SETI provides a potential path to resolving astrobiology's question. Here, I discuss the origins and possible locations for technosignatures of such a prior indigenous technological species, which might have arisen on ancient Earth or another body, such as a pre-greenhouse Venus or a wet Mars. In the case of Venus, the arrival of its global greenhouse and potential resurfacing might have erased all evidence of its existence on the Venusian surface. In the case of Earth, erosion and, ultimately, plate tectonics may have erased most such evidence if the species lived Gyr ago. Remaining indigenous technosignatures might be expected to be extremely old, limiting the places they might still be found to beneath the surfaces of Mars and the Moon, or in the outer solar system.

  12. Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.

    Science.gov (United States)

    Pizzato, Massimo; McCauley, Sean Matthew; Neagu, Martha R; Pertel, Thomas; Firrito, Claudia; Ziglio, Serena; Dauphin, Ann; Zufferey, Madeleine; Berthoux, Lionel; Luban, Jeremy

    2015-07-01

    HIV-2 and SIVMAC are AIDS-causing, zoonotic lentiviruses that jumped to humans and rhesus macaques, respectively, from SIVSM-bearing sooty mangabey monkeys. Cross-species transmission events such as these sometimes necessitate virus adaptation to species-specific, host restriction factors such as TRIM5. Here, a new human restriction activity is described that blocks viruses of the SIVSM/SIVMAC/HIV-2 lineage. Human T, B, and myeloid cell lines, peripheral blood mononuclear cells and dendritic cells were 4 to >100-fold less transducible by VSV G-pseudotyped SIVMAC, HIV-2, or SIVSM than by HIV-1. In contrast, transduction of six epithelial cell lines was equivalent to that by HIV-1. Substitution of HIV-1 CA with the SIVMAC or HIV-2 CA was sufficient to reduce HIV-1 transduction to the level of the respective vectors. Among such CA chimeras there was a general trend such that CAs from epidemic HIV-2 Group A and B isolates were the most infectious on human T cells, CA from a 1° sooty mangabey isolate was the least infectious, and non-epidemic HIV-2 Group D, E, F, and G CAs were in the middle. The CA-specific decrease in infectivity was observed with either HIV-1, HIV-2, ecotropic MLV, or ALV Env pseudotypes, indicating that it was independent of the virus entry pathway. As2O3, a drug that suppresses TRIM5-mediated restriction, increased human blood cell transduction by SIVMAC but not by HIV-1. Nonetheless, elimination of TRIM5 restriction activity did not rescue SIVMAC transduction. Also, in contrast to TRIM5-mediated restriction, the SIVMAC CA-specific block occurred after completion of reverse transcription and the formation of 2-LTR circles, but before establishment of the provirus. Transduction efficiency in heterokaryons generated by fusing epithelial cells with T cells resembled that in the T cells, indicative of a dominant-acting SIVMAC restriction activity in the latter. These results suggest that the nucleus of human blood cells possesses a restriction factor

  13. Mucosal HSV-2 specific CD8+ T-cells represent containment of prior viral shedding rather than a correlate of future protection

    Directory of Open Access Journals (Sweden)

    Joshua Tisdell Schiffer

    2013-07-01

    Full Text Available It is largely unknown why certain infected hosts shed Herpes Simplex Virus-2 (HSV-2 more frequently and have more severe disease manifestations than others. One idea is that different density or functional capacity of tissue resident effector memory CD8+ T-cells between infected persons may explain phenotypic variability. To generate hypotheses for contrasting shedding patterns in different infected hosts, a spatial mathematical model was employed to evaluate the effects of variability in tissue resident effector memory CD8+ T-cell response, and HSV-2 replication and spread, on viral shedding rate. Model simulations suggest that high levels of CD8+ T-cells in the mucosa do not necessarily indicate a protective phenotype but rather an effective response to recent shedding. Moreover, higher CD8+ T-cell expansion rate and lower viral replication rate, which correlate with better short-term control, may have only a minor impact on long term shedding rates. Breakthrough shedding occurs under all sets of model parameter assumptions, because CD8+ T-cell levels only surpass a protective threshold in a minority of genital tract mucosal micro-regions. If CD8+ T-cell levels are artificially increased using an immunotherapeutic approach, better control of shedding is predicted to occur for at least a year. These results highlight the complex co-dependent relationship between HSV-2 and tissue resident CD8+ lymphocytes during the course of natural infection.

  14. Rapid, low-cost MR imaging protocol to document central nervous system and sinus abnormalities prior to pediatric hematopoietic stem cell transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Leite, Eliane D.; Barbosa, Felipe G. de; Szarf, Gilberto; Lederman, Henrique M. [Universidade Federal de Sao Paulo, Department of Diagnostic Imaging, Sao Paulo (Brazil); Seber, Adriana; Ginani, Valeria C.; Carlesse, Fabianne C.; Gouvea, Roseane V.; Zecchin, Victor G.; Carvalho, Cinthya R. [Universidade Federal de Sao Paulo, Division of Pediatric Oncology, Department of Pediatrics, Sao Paulo (Brazil)

    2011-06-15

    Patients undergoing bone marrow transplant (BMT) are at risk for infectious complications, including those of the sinus. Central nervous system (CNS) abnormalities related to the chemotherapy or radiation that the patient received for the treatment of underlying malignancy or to transplant-related effects are also commonly seen. The only effective way to differentiate pre- and post-transplant causes is to have a baseline evaluation prior to the admission for transplant. The current method used to evaluate these patients is head CT. However, CT is not accurate to demonstrate CNS abnormalities and exposes the patient to radiation. MRI, despite better sensitivity for white matter abnormalities, has not been routinely used because of the higher cost and longer duration of the exam. Therefore, we designed a fast, low-cost and radiation-free MRI-based protocol to simultaneously evaluate sinus and brain abnormalities. (orig.)

  15. Combined treatment with pemetrexed and vinflunine in patients with metastatic urothelial cell carcinoma after prior platinum-containing chemotherapy - results of an exploratory phase I study

    DEFF Research Database (Denmark)

    Pappot, H; von der Maase, H; Ullén, A

    2017-01-01

    patients, a phase I trial (VINTREX) was undertaken to assess the safety of vinflunine and pemetrexed in metastatic UCC patients. A dose escalation design was planned to determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of a vinflunine/pemetrexed combination. Pemetrexed was added...... to vinflunine dosed at 280 mg/m2 on day 1 of a 21-day cycle. Three levels of pemetrexed were planned starting at 400 mg/m2. Four patients were enrolled with a mean age of 66 years and with a mean number of prior GC-cycles of 6,8. Two DLT's were observed at the lowest dose-level in cohort 1. One patient...

  16. The Realization and Study of Optical Wings

    Science.gov (United States)

    Artusio-Glimpse, Alexandra Brae

    Consider the airfoil: a carefully designed structure capable of stable lift in a uniform air flow. It so happens that air pressure and radiation (light) pressure are similar phenomena because each transfer momentum to flow-disturbing objects. This, then, begs the question: does an optical analogue to the airfoil exist? Though an exceedingly small effect, scientists harness radiation pressure in a wide gamut of applications from micromanipulation of single biological particles to the propulsion of large spacecrafts called solar sails. We introduce a cambered, refractive rod that is subjected to optical forces analogous to those seen in aerodynamics, and I call this analogue the optical wing. Flight characteristics of optical wings are determined by wing shape and material in a uniform radiation field. Theory predicts the lift force and axial torque are functions of the wing's angle of attack with stable and unstable orientations. These structures can operate as intensity-dependent, parametrically driven oscillators. In two-dimensions, the wings exhibit bistability when analyzed in an accelerating frame. In three-dimensions, the motion of axially symmetric spinning hemispherical wings is analogous to a spinning top. Experiments on semi-buoyant wings in water found semicylindrically shaped, refractive microparticles traversed a laser beam and rotated to an illumination-dependent stable orientation. Preliminary tests aid in the development of a calibrated force measurement experiment to directly evaluate the optical forces and torque on these samples. A foundational study of the optical wing, this work contributes to future advancements of flight-by-light.

  17. The Crest Wing Wave Energy Device

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Antonishen, Michael Patrick

    This report presents the results of a continuation of an experimental study of the wave energy converting abilities of the Crest Wing wave energy converter (WEC), in the following referred to as ‘Phase 2'. The Crest Wing is a WEC that uses its movement in matching the shape of an oncoming wave...

  18. Veins Improve Fracture Toughness of Insect Wings

    Science.gov (United States)

    Dirks, Jan-Henning; Taylor, David

    2012-01-01

    During the lifetime of a flying insect, its wings are subjected to mechanical forces and deformations for millions of cycles. Defects in the micrometre thin membranes or veins may reduce the insect’s flight performance. How do insects prevent crack related material failure in their wings and what role does the characteristic vein pattern play? Fracture toughness is a parameter, which characterises a material’s resistance to crack propagation. Our results show that, compared to other body parts, the hind wing membrane of the migratory locust S. gregaria itself is not exceptionally tough (1.04±0.25 MPa√m). However, the cross veins increase the wing’s toughness by 50% by acting as barriers to crack propagation. Using fracture mechanics, we show that the morphological spacing of most wing veins matches the critical crack length of the material (1132 µm). This finding directly demonstrates how the biomechanical properties and the morphology of locust wings are functionally correlated in locusts, providing a mechanically ‘optimal’ solution with high toughness and low weight. The vein pattern found in insect wings thus might inspire the design of more durable and lightweight artificial ‘venous’ wings for micro-air-vehicles. Using the vein spacing as indicator, our approach might also provide a basis to estimate the wing properties of endangered or extinct insect species. PMID:22927966

  19. Effect of leading edge roundness on a delta wing in wing-rock motion

    Science.gov (United States)

    Ng, T. Terry; Malcolm, Gerald N.

    1990-01-01

    The effect of wing leading-edge roundness on wing rock was investigated using flow visualization in a water tunnel. Eighty degree delta wing models were tested on free-to-roll and forced oscillation rigs. The onset of wing rock was delayed by increasing the roundness of the leading edges. The wing rock amplitude and frequency results suggested that damping was increased at lower angles of attack but reduced at higher angles of attack. Vortex lift-off and vortex breakdown, especially during dynamic situations, were strongly affected by the leading edge roundness. Different forms of wing rock motion could be sustained by combinations of vortex breakdown and vortex lift-off. Behaviors of the wing and vortex motions were explained by the influence of leading edge roundness on the separation location, vortex trajectory, and vortex breakdown.

  20. Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro.

    Science.gov (United States)

    Tagoh, Hiromi; Melnik, Svitlana; Lefevre, Pascal; Chong, Suyinn; Riggs, Arthur D; Bonifer, Constanze

    2004-04-15

    In order to gain insights in the true molecular mechanisms involved in cell fate decisions, it is important to study the molecular details of gene activation where such decisions occur, which is at the level of the chromatin structure of individual genes. In the study presented here we addressed this issue and examined the dynamic development of an active chromatin structure at the chicken lysozyme locus during the differentiation of primary myeloid cells from transgenic mouse bone marrow. Using in vivo footprinting we found that stable enhancer complex assembly and high-level gene expression are late events in cell differentiation. However, even before the onset of gene expression and stable transcription factor binding, specific chromatin alterations are observed. This includes changes in DNA topology and the selective demethylation of CpG dinucleotides located in the cores of critical transcription factor binding sites, but not in flanking DNA. These results firmly support the idea that epigenetic programs guiding blood cell differentiation are engraved into the chromatin of lineage-specific genes and that such chromatin changes are implemented before cell lineage specification.

  1. Memory T cells generated by prior exposure to influenza cross react with the novel H7N9 influenza virus and confer protective heterosubtypic immunity.

    Directory of Open Access Journals (Sweden)

    Sean R McMaster

    Full Text Available Influenza virus is a source of significant health and economic burden from yearly epidemics and sporadic pandemics. Given the potential for the emerging H7N9 influenza virus to cause severe respiratory infections and the lack of exposure to H7 and N9 influenza viruses in the human population, we aimed to quantify the H7N9 cross-reactive memory T cell reservoir in humans and mice previously exposed to common circulating influenza viruses. We identified significant cross-reactive T cell populations in humans and mice; we also found that cross-reactive memory T cells afforded heterosubtypic protection by reducing morbidity and mortality upon lethal H7N9 challenge. In context with our observation that PR8-primed mice have limited humoral cross-reactivity with H7N9, our data suggest protection from H7N9 challenge is indeed mediated by cross-reactive T cell populations established upon previous priming with another influenza virus. Thus, pre-existing cross-reactive memory T cells may limit disease severity in the event of an H7N9 influenza virus pandemic.

  2. Dpp spreading is required for medial but not for lateral wing disc growth.

    Science.gov (United States)

    Harmansa, Stefan; Hamaratoglu, Fisun; Affolter, Markus; Caussinus, Emmanuel

    2015-11-19

    Drosophila Decapentaplegic (Dpp) has served as a paradigm to study morphogen-dependent growth control. However, the role of a Dpp gradient in tissue growth remains highly controversial. Two fundamentally different models have been proposed: the 'temporal rule' model suggests that all cells of the wing imaginal disc divide upon a 50% increase in Dpp signalling, whereas the 'growth equalization model' suggests that Dpp is only essential for proliferation control of the central cells. Here, to discriminate between these two models, we generated and used morphotrap, a membrane-tethered anti-green fluorescent protein (GFP) nanobody, which enables immobilization of enhanced (e)GFP::Dpp on the cell surface, thereby abolishing Dpp gradient formation. We find that in the absence of Dpp spreading, wing disc patterning is lost; however, lateral cells still divide at normal rates. These data are consistent with the growth equalization model, but do not fit a global temporal rule model in the wing imaginal disc.

  3. Overview of recent progress on the DARPA/USAF Wright Laboratory Smart Materials and Structures Development--Smart Wing program

    Science.gov (United States)

    Kudva, Jayanth N.; Appa, Kari; Jardine, A. Peter; Martin, Christopher A.; Carpenter, Bernie F.

    1997-05-01

    The concept of an adaptive aircraft wing, i.e., whose shape parameters such as camber, span-wise twist, and thickness can be varied to optimize the wing shape for various flight conditions, has been extensively studied by numerous researchers. While the aerodynamic benefits (in terms of increased lift/drag ratios, improved maneuverability, and delayed flow separation) have been analytically and experimentally established, the complexity and weight penalty of the designs and actuation using smart materials could potentially alleviate the shortcomings of prior designs, leading the way to a more practical `smart' adaptive wing which responds to changes in flight and environmental conditions by optimally modifying its shape. A summary of recent work in the area of adaptive wing concepts incorporating smart structures technologies is presented. Emphasis is placed on continuing research at Northrop Grumman under a United States Defense Advanced Research Projects Agency contract entitled `Smart Structures and Materials Development-Smart Wing,'. Limitations and potential benefits of adaptive wing designs, applications and advantages of smart material actuators and sensors, and results of recent tests are discussed. Recommendations for future work required to develop an operational smart adaptive wing are also outlined.

  4. Absolute lymphocyte count predicts response to rituximab-containing salvage treatment for relapsed/refractory B-cell non-Hodgkin's lymphoma with prior rituximab exposure

    Directory of Open Access Journals (Sweden)

    Man-Hsin Hung

    2013-04-01

    Conclusion: Our study results show that for patients with relapsed/refractory B-cell NHL, rituximab-containing salvage treatment is feasible and generally tolerable. A high ALC-R value was significantly associated with a better response to this treatment.

  5. Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.

    Science.gov (United States)

    Wilmes, Anja; Rauch, Caroline; Carta, Giada; Kern, Georg; Meier, Florian; Posch, Wilfried; Wilflingseder, Doris; Armstrong, Lyle; Lako, Majlinda; Beilmann, Mario; Gstraunthaler, Gerhard; Jennings, Paul

    2017-12-01

    Human induced pluripotent stem cells (iPSC) have the potential to radically reduce the number of animals used in both toxicological science and disease elucidation. One initial obstacle culturing iPSC is that they require daily medium exchange. This study attempts to clarify why and propose some practical solutions. Two iPSC lineages were fed at different intervals in a full growth area (FGA) or a restricted growth area (RGA). The FGA consisted of a well coated with Matrigel™ and the RGA consisted of a coated coverslip placed in a well. Glucose, lactate, extracellular pH and cell cycle phases were quantified. Without daily feeding, FGA cultured iPSC had significantly reduced growth rates by day 2 and began to die by day 3. In contrast, RGA cultured cells grew to confluence over 3days. Surprisingly, glucose was not exhausted under any condition. However, extracellular pH reached 6.8 after 72h in FGA cultures. Artificially reducing medium pH to 6.8 also inhibited glycolysis and initiated an increase in G0/G1 phase of the cell cycle, while adding an additional 10mM bicarbonate to the medium increased glycolysis rates. This study demonstrates that iPSC are highly sensitive to extracellular acidification, a likely limiting factor in maintenance of proliferative and pluripotent status. Culturing iPSC in RGA prevents rapid extracellular acidification, while still maintaining pluripotency and allowing longer feeding cycles. Copyright © 2017. Published by Elsevier Ltd.

  6. Peripheral-blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied ril-2 therapy of renal-cell carcinoma

    NARCIS (Netherlands)

    Janssen, R. A. J.; Sleijfer, D. T.; Heijn, A. A.; Mulder, N. H.; The, T. Hauw; de Leij, L.

    1992-01-01

    The phenotype of peripheral blood lymphocytes of 27 renal cell carcinoma patients before and at the end of subcutaneously given rIL-2 therapy was determined by two colour flow cytometry. Therapy induced changes in peripheral blood leucocyte composition and phenotypes were comparable to those

  7. Prior lactose glycation of caseinate via the Maillard reaction affects in vitro activities of the pepsin-trypsin digest toward intestinal epithelial cells.

    Science.gov (United States)

    Wang, X P; Zhao, X H

    2017-07-01

    The well-known Maillard reaction in milk occurs between lactose and milk proteins during thermal treatment, and its effects on milk nutrition and safety have been well studied. A lactose-glycated caseinate was prepared via this reaction and digested using 2 digestive proteases, pepsin and trypsin. The glycated caseinate digest was assessed for its in vitro activities on rat intestinal epithelial cells in terms of growth proliferation, anti-apoptotic effect, and differentiation induction using caseinate digest as reference, to verify potential effects of the Maillard reaction on these activities of caseinate digest to the cells. Two digests had proliferative and anti-apoptotic effects, and reached the highest effects at 0.02 g/L of digest concentration with treatment time of 24 h. In comparison with caseinate digest, glycated caseinate digest always showed weaker proliferative (5.3-14.2%) and anti-apoptotic (5.9-39.0%) effects, and was more toxic to the cells at 0.5 g/L of digest concentration with treatment time of 48 h. However, glycated caseinate digest at 2 incubation times of 4 to 7 d showed differentiation induction higher than caseinate digest, as it could confer the cells with increased activities in lactase (16.3-26.6%), sucrase (22.4-31.2%), and alkaline phosphatase (17.4-24.8%). Transmission electron microscopy observation results also confirmed higher differentiation induction of glycated caseinate digest. Amino acid loss and lactose glycation partially contributed to these decreased and enhanced activities of glycated caseinate digest, respectively. The Maillard reaction of caseinate and lactose is thus shown in this study to have effects on the activities of caseinate digest to intestinal epithelial cells. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  8. AEROELASTIC FLUTTER ANALYSIS OF SUPERSONIC WING WITH MULTIPLE EXTERNAL STORES

    Directory of Open Access Journals (Sweden)

    Nur Azam

    2014-12-01

    Full Text Available ABSTRACT: Flutter may be considered to be one of the most dangerous aeroelastic failure phenomenon. The flutter characteristic differs for each aircraft type, and depends on the wing geometry as well as its operational region of subsonic, transonic or supersonic speeds. Prior to performing a flight flutter test, extensive numerical simulations and Ground Vibration Test should be conducted where the structural finite element modes and the experimentation results should be matched, otherwise the numerical simulation model must be rejected. In this paper, the analysis of simulation of a supersonic wing equipped with external missiles loaded on the wing is presented. The structural mode shapes at each generated frequency are also visually presented. The analysis is carried out using MSC Nastran FEM software. The wing flutter with the external stores was simulated at different altitudes. The result shows that the flutter velocity is sensitive to the flight altitude. For this reason, the flutter analysis is conducted also for a negative altitude. The negative altitude is obtained by considering the constant equivalent speed-Mach number rule at the flutter speed boundary as a requirement in standard regulation of transport aircraft. ABSTRAK: Salah satu fenomena kegagalan aeroelastik yang paling membahayakan adalah kipasan (flutter. Ciri-ciri kegagalan kipasan (flutter adalah berbeza untuk setiap jenis pesawat bergantung pada geometri sayap dan regim operasi sama ada subsonik, transonik atau supersonik. Sebelum melakukan ujian penerbangan kipasan , simulasi berangka luas dan ujian getaran peringkat bawahan (darat perlu dijalankan di mana struktur mod unsur terhingga dan keputusan eksperimen harus dipadankan, sebaliknya model simulasi berangka boleh ditolak. Dalam kertas kerja ini, simulasi sayap supersonik dilengkapi dengan beban luaran peluru berpandu di sayap telah dianalisis di daerah supersonik tinggi. Bentuk mod struktur pada setiap mod frekuensi

  9. Hovering hummingbird wing aerodynamics during the annual cycle. II. Implications of wing feather moult

    Science.gov (United States)

    Sapir, Nir; Elimelech, Yossef

    2018-01-01

    Birds usually moult their feathers in a particular sequence which may incur aerodynamic, physiological and behavioural implications. Among birds, hummingbirds are unique species in their sustained hovering flight. Because hummingbirds frequently hover-feed, they must maintain sufficiently high flight capacities even when moulting their flight feathers. A hummingbird wing consists of 10 primary flight feathers whose absence during moult may strongly affect wing performance. Using dynamic similarity rules, we compared time-accurate aerodynamic loads and flow field measurements over several wing geometries that follow the natural feather moult sequence of Calypte anna, a common hummingbird species in western North America. Our results suggest a drop of more than 20% in lift production during the early stages of the moult sequence in which mid-wing flight feathers are moulted. We also found that the wing's ability to generate lift strongly depended on the morphological integrity of the outer primaries and leading-edge. These findings may explain the evolution of wing morphology and moult attributes. Specifically, the high overlap between adjacent wing feathers, especially at the wing tip, and the slow sequential replacement of the wing feathers result in a relatively small reduction in wing surface area during moult with limited aerodynamic implications. We present power and efficiency analyses for hover flight during moult under several plausible scenarios, suggesting that body mass reduction could be a compensatory mechanism that preserves the energetic costs of hover flight. PMID:29515884

  10. Protection of human cells against the effects of cadmium chloride by pretreatment with vitamins, interferon, and prior low-dose γ-irradiation

    International Nuclear Information System (INIS)

    Kusainova, K.A.; Vasil'eva, I.M.; Chekova, V.V.; Akhmatullina, N.B.; Zasukhina, G.D.

    1992-01-01

    Within the increasing environmental pollution there is a need to discover means to protect humans from the mutagenic effects of chemical pollutants. Natural antimutagens such as interferon and vitamins have some protective properties. Interferons simulate a variety of repair pathways in human cells and reduce the numbers of mutations induced by physical and chemical mutagens. This study compares the protective properties of interferon and vitamins with the known protective effects of small doses of ionizing radiation

  11. Semi-automated quantitative Drosophila wings measurements.

    Science.gov (United States)

    Loh, Sheng Yang Michael; Ogawa, Yoshitaka; Kawana, Sara; Tamura, Koichiro; Lee, Hwee Kuan

    2017-06-28

    Drosophila melanogaster is an important organism used in many fields of biological research such as genetics and developmental biology. Drosophila wings have been widely used to study the genetics of development, morphometrics and evolution. Therefore there is much interest in quantifying wing structures of Drosophila. Advancement in technology has increased the ease in which images of Drosophila can be acquired. However such studies have been limited by the slow and tedious process of acquiring phenotypic data. We have developed a system that automatically detects and measures key points and vein segments on a Drosophila wing. Key points are detected by performing image transformations and template matching on Drosophila wing images while vein segments are detected using an Active Contour algorithm. The accuracy of our key point detection was compared against key point annotations of users. We also performed key point detection using different training data sets of Drosophila wing images. We compared our software with an existing automated image analysis system for Drosophila wings and showed that our system performs better than the state of the art. Vein segments were manually measured and compared against the measurements obtained from our system. Our system was able to detect specific key points and vein segments from Drosophila wing images with high accuracy.

  12. Novel Control Effectors for Truss Braced Wing

    Science.gov (United States)

    White, Edward V.; Kapania, Rakesh K.; Joshi, Shiv

    2015-01-01

    At cruise flight conditions very high aspect ratio/low sweep truss braced wings (TBW) may be subject to design requirements that distinguish them from more highly swept cantilevered wings. High aspect ratio, short chord length and relative thinness of the airfoil sections all contribute to relatively low wing torsional stiffness. This may lead to aeroelastic issues such as aileron reversal and low flutter margins. In order to counteract these issues, high aspect ratio/low sweep wings may need to carry additional high speed control effectors to operate when outboard ailerons are in reversal and/or must carry additional structural weight to enhance torsional stiffness. The novel control effector evaluated in this study is a variable sweep raked wing tip with an aileron control surface. Forward sweep of the tip allows the aileron to align closely with the torsional axis of the wing and operate in a conventional fashion. Aft sweep of the tip creates a large moment arm from the aileron to the wing torsional axis greatly enhancing aileron reversal. The novelty comes from using this enhanced and controllable aileron reversal effect to provide roll control authority by acting as a servo tab and providing roll control through intentional twist of the wing. In this case the reduced torsional stiffness of the wing becomes an advantage to be exploited. The study results show that the novel control effector concept does provide roll control as described, but only for a restricted class of TBW aircraft configurations. For the configuration studied (long range, dual aisle, Mach 0.85 cruise) the novel control effector provides significant benefits including up to 12% reduction in fuel burn.

  13. Prior Elicitation, Assessment and Inference with a Dirichlet Prior

    Directory of Open Access Journals (Sweden)

    Michael Evans

    2017-10-01

    Full Text Available Methods are developed for eliciting a Dirichlet prior based upon stating bounds on the individual probabilities that hold with high prior probability. This approach to selecting a prior is applied to a contingency table problem where it is demonstrated how to assess the prior with respect to the bias it induces as well as how to check for prior-data conflict. It is shown that the assessment of a hypothesis via relative belief can easily take into account what it means for the falsity of the hypothesis to correspond to a difference of practical importance and provide evidence in favor of a hypothesis.

  14. Leading-edge flow reattachment and the lateral static stability of low-aspect-ratio rectangular wings

    Science.gov (United States)

    Linehan, Thomas; Mohseni, Kamran

    2017-11-01

    The relationship between lateral static stability derivative, Clβ,lift coefficient, CL, and angle of attack was investigated for rectangular wings of aspect ratio A R =0.75 ,1 ,1.5 , and 3 using Stereo-Digital Particle Image Velocimetry (S-DPIV) and direct force and moment measurements. When the product Cl βA R is plotted with respect to CL, the lateral stability curves of each wing collapse to a single line for CL0.7 , the linearity and scaling of Clβwith respect to CL is lost. S-DPIV is used to elucidate the flow physics in this nonlinear regime. At α =10∘ , the leading-edge separation region emerges on the leeward portion of the sideslipped wing by means of vortex shedding. For the A R ≤1.5 wings at α >15∘ , the tip vortex downwash is sufficient to restrict the shedding of leading-edge vorticity thereby sustaining the lift of the leading-edge separation region at high angles of attack. Concurrently, the windward tip vortex grows in size and strength with increasing angle of attack, displacing the leading-edge separation region further toward the leeward wing. This reorganization of lift-generating vorticity results in the initial nonlinearities between Cl β and CL at angles of attack for which CL is still increasing. At angles of attack near that of maximum lift for the A R ≤1 wings, the windward tip vortex lifts off the wing, decreasing the lateral static stability of the wing prior to lift stall. For the A R =3 wing at α >10∘ , nonlinear trends in Cl β versus CL occur due to the spanwise evolution of stalled flow.

  15. Nonlinear Structures Optimization for Flexible Flapping Wing MAVs

    Science.gov (United States)

    2009-02-01

    nonlinear optimization, flapping wing, fluid structure interaction, micro -air vehicles, flexible wing, flapping mechanism 16. SECURITY... Structures Optimization for Flexible Flapping Wing Micro -Air Vehicles” was funded with Chief Scientist Innovative Research funds. This project was divided...predict a 10% resisting load to the model, and Python Scripting to wrap around everything. 2 Building the Model in Abaqus CAE The flapping wing

  16. Generic Wing-Body Aerodynamics Data Base

    Science.gov (United States)

    Holst, Terry L.; Olsen, Thomas H.; Kwak, Dochan (Technical Monitor)

    2001-01-01

    The wing-body aerodynamics data base consists of a series of CFD (Computational Fluid Dynamics) simulations about a generic wing body configuration consisting of a ogive-circular-cylinder fuselage and a simple symmetric wing mid-mounted on the fuselage. Solutions have been obtained for Nonlinear Potential (P), Euler (E) and Navier-Stokes (N) solvers over a range of subsonic and transonic Mach numbers and angles of attack. In addition, each solution has been computed on a series of grids, coarse, medium and fine to permit an assessment of grid refinement errors.

  17. Unemployment and Right-Wing Extremist Crime

    OpenAIRE

    Falk, Armin; Zweimüller, Josef

    2005-01-01

    Right-wing extremism is a serious problem in many societies. A prominent hypothesis states that unemployment plays a crucial role for the occurrence of right-wing extremist crime. In this paper we empirically test this hypothesis. We use a previously not used data set which includes all officially recorded right-wing criminal acts in Germany. These data are recorded by the German Federal Criminal Police Office on a monthly and state level basis. Our main finding is that there is in fact a sig...

  18. Relationships among seminal culture, seminal white blood cells, and the percentage of primary sperm abnormalities in bulls evaluated prior to the breeding season.

    Science.gov (United States)

    Sprecher, D J; Coe, P H; Walker, R D

    1999-04-15

    Semen samples from 100 beef breed bulls were evaluated for sperm morphology (phased contrast microscopy), seminal white blood cells, and the presence of potential reproductive pathogens. Eligibility required visualization of the glans penis throughout semen collection. Based on clinical spermiograms, bulls were grouped into normal, marginal, or unsatisfactory morphology classifications. The 3 experimental groups were similar in age and scrotal circumference and differed significantly in the percentage of primary sperm abnormalities. Most semen samples (94%) contained one or more potential reproductive pathogens (Hemophilus somnus. Mycoplasma bovigenitalium, Arcanobacterium pyogenes and Ureaplasma diversum). No significant relationship could be demonstrated between primary abnormalities and the assigned culture score. Our experimental results suggest that clinicians should interpret clinical semen culture results with great care. No significant relationship could be demonstrated between primary abnormalities and assigned white blood cell (WBC) score, although, only 1% of the samples was scored >5 WBC per high power field. The use of seminal WBC score may be valid adjunct to routine semen evaluation when that threshold is the basis for clinical decisions.

  19. Notch inhibits Yorkie activity in Drosophila wing discs.

    Directory of Open Access Journals (Sweden)

    Alexandre Djiane

    Full Text Available During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki, the Salvador/Warts/Hippo (SWH pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg. We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.

  20. The leading-edge vortex of swift-wing shaped delta wings

    Science.gov (United States)

    Muir, Rowan; Arredondo-Galeana, Abel; Viola, Ignazio Maria

    2017-11-01

    Recent investigations on the aerodynamics of natural fliers have illuminated the significance of the Leading-Edge Vortex (LEV) for lift generation in a variety of flight conditions. In this investigation, a model non-slender delta shaped wing with a sharp leading-edge is tested at low Reynolds Number, along with a delta wing of the same design, but with a modified trailing edge inspired by the wing of a common swift Apus apus. The effect of the tapering swift wing on LEV development and stability is compared with the flow structure over the un-modified delta wing model through particle image velocimetry. For the first time, a leading-edge vortex system consisting of a dual or triple LEV is recorded on a swift-wing shaped delta wing, where such a system is found across all tested conditions. It is shown that the spanwise location of LEV breakdown is governed by the local chord rather than Reynolds Number or angle of attack. These findings suggest that the trailing-edge geometry of the swift wing alone does not prevent the common swift from generating an LEV system comparable with that of a delta shaped wing. This work received funding from the Engineering and Physical Sciences Research Council [EP/M506515/1] and the Consejo Nacional de Ciencia y Tecnología (CONACYT).

  1. Fruit fly scale robots can hover longer with flapping wings than with spinning wings.

    Science.gov (United States)

    Hawkes, Elliot W; Lentink, David

    2016-10-01

    Hovering flies generate exceptionally high lift, because their wings generate a stable leading edge vortex. Micro flying robots with a similar wing design can generate similar high lift by either flapping or spinning their wings. While it requires less power to spin a wing, the overall efficiency depends also on the actuator system driving the wing. Here, we present the first holistic analysis to calculate how long a fly-inspired micro robot can hover with flapping versus spinning wings across scales. We integrate aerodynamic data with data-driven scaling laws for actuator, electronics and mechanism performance from fruit fly to hummingbird scales. Our analysis finds that spinning wings driven by rotary actuators are superior for robots with wingspans similar to hummingbirds, yet flapping wings driven by oscillatory actuators are superior at fruit fly scale. This crossover is driven by the reduction in performance of rotary compared with oscillatory actuators at smaller scale. Our calculations emphasize that a systems-level analysis is essential for trading-off flapping versus spinning wings for micro flying robots. © 2016 The Author(s).

  2. Flow Modulation and Force Control of Flapping Wings

    Science.gov (United States)

    2014-10-29

    tested on a flapping wing model in the oil tank. Robotic flapper equipped with DC motors drove the wing model, and the imbedded servo motor could flap...the overall wake structure on the hovering wings. Totally, two volumetric flow measurements were performed on two mechanical flappers with different...wing kinematics but similar wing geometry. On the flappers with small stroke angle and passive rotation, the general vortex wake structure

  3. Irradiated cocoa tested in the wing spot assay in Drosophila melanogaster

    International Nuclear Information System (INIS)

    Zimmering, S.; Olvera, O.; Cruces, M.P.; Pimentel, E.; Arceo, C.; Rosa, M.E. de la; Guzman, J.

    1992-01-01

    The result of treatment of Drosophila melanogaster with irradiated cocoa as scored in the somatic wing spot test is described. The test has been used previously in the evaluation of irradiated food and has registrated a significantly greater number of positives among chemicals tested than germ line counterparts. Irradiated cocoa has thus far been reported negative in other mutagenicity assays including those employing salmonella and Drosophila germ cells and mammalian cells. The wing spot test as described in Graf et al. was employed. Females of the genotype mwh were mated with flr 3 /TM3; Ser males. (author). 9 refs.; 1 tab

  4. Left-Wing Extremism: The Current Threat

    Energy Technology Data Exchange (ETDEWEB)

    Karl A. Seger

    2001-04-30

    Left-wing extremism is ''alive and well'' both in the US and internationally. Although the current domestic terrorist threat within the U. S. is focused on right-wing extremists, left-wing extremists are also active and have several objectives. Leftist extremists also pose an espionage threat to U.S. interests. While the threat to the U.S. government from leftist extremists has decreased in the past decade, it has not disappeared. There are individuals and organizations within the U.S. who maintain the same ideology that resulted in the growth of left-wing terrorism in this country in the 1970s and 1980s. Some of the leaders from that era are still communicating from Cuba with their followers in the U.S., and new leaders and groups are emerging.

  5. A galactic microquasar mimicking winged radio galaxies.

    Science.gov (United States)

    Martí, Josep; Luque-Escamilla, Pedro L; Bosch-Ramon, Valentí; Paredes, Josep M

    2017-11-24

    A subclass of extragalactic radio sources known as winged radio galaxies has puzzled astronomers for many years. The wing features are detected at radio wavelengths as low-surface-brightness radio lobes that are clearly misaligned with respect to the main lobe axis. Different models compete to account for these peculiar structures. Here, we report observational evidence that the parsec-scale radio jets in the Galactic microquasar GRS 1758-258 give rise to a Z-shaped radio emission strongly reminiscent of the X and Z-shaped morphologies found in winged radio galaxies. This is the first time that such extended emission features are observed in a microquasar, providing a new analogy for its extragalactic relatives. From our observations, we can clearly favour the hydrodynamic backflow interpretation against other possible wing formation scenarios. Assuming that physical processes are similar, we can extrapolate this conclusion and suggest that this mechanism could also be at work in many extragalactic cases.

  6. Flow structure of vortex-wing interaction

    Science.gov (United States)

    McKenna, Christopher K.

    Impingement of a streamwise-oriented vortex upon a fin, tail, blade or wing represents a fundamental class of flow-structure interaction that extends across a range of applications. This interaction can give rise to time-averaged loading, as well as unsteady loading known as buffeting. The loading is sensitive to parameters of the incident vortex as well as the location of vortex impingement on the downstream aerodynamic surface, generically designated as a wing. Particle image velocimetry is employed to determine patterns of velocity, vorticity, swirl ratio, and streamlines on successive cross-flow planes upstream of and along the wing, which lead to volume representations and thereby characterization of the interaction. At locations upstream of the leading edge of the wing, the evolution of the incident vortex is affected by the presence of the wing, and is highly dependent on the spanwise location of vortex impingement. Even at spanwise locations of impingement well outboard of the wing tip, a substantial influence on the structure of the incident vortex at locations significantly upstream of the leading edge of the wing was observed. For spanwise locations close to or intersecting the vortex core, the effects of upstream influence of the wing on the vortex are to: decrease the swirl ratio; increase the streamwise velocity deficit; decrease the streamwise vorticity; increase the azimuthal vorticity; increase the upwash; decrease the downwash; and increase the root-mean-square fluctuations of both streamwise velocity and vorticity. The interrelationship between these effects is addressed, including the rapid attenuation of axial vorticity in presence of an enhanced defect of axial velocity in the central region of the vortex. Moreover, when the incident vortex is aligned with, or inboard of, the tip of the wing, the swirl ratio decreases to values associated with instability of the vortex, giving rise to enhanced values of azimuthal vorticity relative to the

  7. Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis

    International Nuclear Information System (INIS)

    Watanabe, Satoshi; Miyabayashi, Takao; Narita, Ichiei; Yoshizawa, Hirohisa; Tanaka, Junta; Ota, Takeshi; Kondo, Rie; Tanaka, Hiroshi; Kagamu, Hiroshi; Ichikawa, Kosuke; Koshio, Jun; Baba, Junko

    2011-01-01

    Gefitinib was the first epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC). Few treatment options are available for NSCLC patients who have responded to gefitinib treatment and demonstrated tumor progression. The present study was conducted to evaluate the efficacy and toxicity of the 2 nd EGFR-TKI administration. We retrospectively analyzed 11 patients who had obtained a partial response (PR) or stable disease (SD) with gefitinib treatment and were re-treated with EGFR-TKI after failure of the initial gefitinib treatment. Three patients (27%) were treated with gefitinib as the 2 nd EGFR-TKI, and 8 patients (73%) received erlotinib. Only one patient (9%) showed PR, 7 (64%) achieved SD, and 3 (27%) had progressive disease. The disease control rate was 73% (95% CI, 43% - 91%) and the median progression-free survival was 3.4 months (95% CI, 2 - 5.2). The median overall survival from the beginning of the 2 nd EGFR-TKI and from diagnosis were 7.3 months (95% CI, 2.7 - 13) and 36.7 months (95% CI, 23.6 - 43.9), respectively. No statistical differences in PFS or OS were observed between gefitinib and erlotinib as the 2 nd EGFR-TKI (PFS, P = 0.23 and OS, P = 0.052). The toxicities associated with the 2 nd EGFR-TKI were generally acceptable and comparable to those observed for the initial gefitinib therapy. Our results indicate that a 2 nd EGFR-TKI treatment can be an effective treatment option for gefitinib responders

  8. The leading-edge vortex of swift wing-shaped delta wings.

    Science.gov (United States)

    Muir, Rowan Eveline; Arredondo-Galeana, Abel; Viola, Ignazio Maria

    2017-08-01

    Recent investigations on the aerodynamics of natural fliers have illuminated the significance of the leading-edge vortex (LEV) for lift generation in a variety of flight conditions. A well-documented example of an LEV is that generated by aircraft with highly swept, delta-shaped wings. While the wing aerodynamics of a manoeuvring aircraft, a bird gliding and a bird in flapping flight vary significantly, it is believed that this existing knowledge can serve to add understanding to the complex aerodynamics of natural fliers. In this investigation, a model non-slender delta-shaped wing with a sharp leading edge is tested at low Reynolds number, along with a delta wing of the same design, but with a modified trailing edge inspired by the wing of a common swift Apus apus . The effect of the tapering swift wing on LEV development and stability is compared with the flow structure over the unmodified delta wing model through particle image velocimetry. For the first time, a leading-edge vortex system consisting of a dual or triple LEV is recorded on a swift wing-shaped delta wing, where such a system is found across all tested conditions. It is shown that the spanwise location of LEV breakdown is governed by the local chord rather than Reynolds number or angle of attack. These findings suggest that the trailing-edge geometry of the swift wing alone does not prevent the common swift from generating an LEV system comparable with that of a delta-shaped wing.

  9. Aeroelasticity of morphing wings using neural networks

    Science.gov (United States)

    Natarajan, Anand

    In this dissertation, neural networks are designed to effectively model static non-linear aeroelastic problems in adaptive structures and linear dynamic aeroelastic systems with time varying stiffness. The use of adaptive materials in aircraft wings allows for the change of the contour or the configuration of a wing (morphing) in flight. The use of smart materials, to accomplish these deformations, can imply that the stiffness of the wing with a morphing contour changes as the contour changes. For a rapidly oscillating body in a fluid field, continuously adapting structural parameters may render the wing to behave as a time variant system. Even the internal spars/ribs of the aircraft wing which define the wing stiffness can be made adaptive, that is, their stiffness can be made to vary with time. The immediate effect on the structural dynamics of the wing, is that, the wing motion is governed by a differential equation with time varying coefficients. The study of this concept of a time varying torsional stiffness, made possible by the use of active materials and adaptive spars, in the dynamic aeroelastic behavior of an adaptable airfoil is performed here. Another type of aeroelastic problem of an adaptive structure that is investigated here, is the shape control of an adaptive bump situated on the leading edge of an airfoil. Such a bump is useful in achieving flow separation control for lateral directional maneuverability of the aircraft. Since actuators are being used to create this bump on the wing surface, the energy required to do so needs to be minimized. The adverse pressure drag as a result of this bump needs to be controlled so that the loss in lift over the wing is made minimal. The design of such a "spoiler bump" on the surface of the airfoil is an optimization problem of maximizing pressure drag due to flow separation while minimizing the loss in lift and energy required to deform the bump. One neural network is trained using the CFD code FLUENT to

  10. Accommodating Uncertainty in Prior Distributions

    Energy Technology Data Exchange (ETDEWEB)

    Picard, Richard Roy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Vander Wiel, Scott Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-19

    A fundamental premise of Bayesian methodology is that a priori information is accurately summarized by a single, precisely de ned prior distribution. In many cases, especially involving informative priors, this premise is false, and the (mis)application of Bayes methods produces posterior quantities whose apparent precisions are highly misleading. We examine the implications of uncertainty in prior distributions, and present graphical methods for dealing with them.

  11. Hovering hummingbird wing aerodynamics during the annual cycle. I. Complete wing.

    Science.gov (United States)

    Achache, Yonathan; Sapir, Nir; Elimelech, Yossef

    2017-08-01

    The diverse hummingbird family (Trochilidae) has unique adaptations for nectarivory, among which is the ability to sustain hover-feeding. As hummingbirds mainly feed while hovering, it is crucial to maintain this ability throughout the annual cycle-especially during flight-feather moult, in which wing area is reduced. To quantify the aerodynamic characteristics and flow mechanisms of a hummingbird wing throughout the annual cycle, time-accurate aerodynamic loads and flow field measurements were correlated over a dynamically scaled wing model of Anna's hummingbird ( Calypte anna ). We present measurements recorded over a model of a complete wing to evaluate the baseline aerodynamic characteristics and flow mechanisms. We found that the vorticity concentration that had developed from the wing's leading-edge differs from the attached vorticity structure that was typically found over insects' wings; firstly, it is more elongated along the wing chord, and secondly, it encounters high levels of fluctuations rather than a steady vortex. Lift characteristics resemble those of insects; however, a 20% increase in the lift-to-torque ratio was obtained for the hummingbird wing model. Time-accurate aerodynamic loads were also used to evaluate the time-evolution of the specific power required from the flight muscles, and the overall wingbeat power requirements nicely matched previous studies.

  12. Resilin-based rubber-like elements in the insect wing: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Gorb, S.N. [Max-Planck-Institut fuer Entwicklungsbiologie, Tuebingen (Germany). Abt. Biochemie

    2001-06-01

    Wings of insects are complex structures which are designed to enable controlled torsion essential to flapping flight. Although wing morphology and flight types diversified enormously among a huge number of insect species, the general principle of insect flight remained the same. All muscles are located in the thorax proper, the wing itself is complete without any muscles. Data on the nature and distribution of materials involved in wing design are essential for understanding both the aerodynamics and evolution of insect flight. An insect wing consists of a three-dimensional skeletal network of relatively hard veins which are interconnected through thin membranous areas called cells. These structures consists of cuticle, a biological fibrous composite material, the mechanical properties of which may range from very stiff to flexible, depending on its chemical composition. This report summarises data on the presence of resilin, a rubber-like protein in the flexibly-joined junctions of wing veins. This protein is a substance which is responsible for elastic energy storage. Any folding of the distal wing parts can not be achieved by local muscles, but must be done by remote (thoracic) muscles or local elasticity. Many insects, such as earwigs and beetles, have developed complex mechanisms of wing folding, which are advantageous for insects living in soil or other narrow substrata. The folding pattern depends on the wing geometry, venation pattern, and material properties of structures involved. Thus, design of wings with folding functions has an additional complexity: their design is a kind of compromise between flight and folding. (orig.) [German] Biomechanische Systeme, in denen gummiartige Gelenke vorkommen, reichen von den Sprungsystemen von Kaefern, Floehen, Schaumzikaden und Heuschrecken bis Saugpumpen von Wanzen und Fliegen. Resilin ist ein elastisches Strukturprotein, dessen Name sich vom lateinischen Wort fuer 'zurueckschnellen' herleitet. Sein

  13. The effects of wing flexibility on the flight performance and stability of flapping wing micro air vehicles

    Science.gov (United States)

    Bluman, James Edward

    Insect wings are flexible. However, the influence of wing flexibility on the flight dynamics of insects and flapping wing micro air vehicles is unknown. Most studies in the literature consider rigid wings and conclude that the hover equilibrium is unstable. This dissertation shows that a flapping wing flyer with flexible wings exhibits stable natural modes of the open loop system in hover, never reported before. The free-flight insect flight dynamics is modeled for both flexible and rigid wings. Wing mass and inertia are included in the nonlinear equations of motion. The flapping wing aerodynamics are modeled using a quasi-steady model, a well-validated two dimensional Navier Stokes model, and a coupled, two dimensional Navier Stokes - Euler Bernoulli beam model that accurately models the fluid-structure interaction of flexible wings. Hover equilibrium is systematically and efficiently determined with a coupled quasi-steady and Navier-Stokes equation trimmer. The power and stability are reported at hover while parametrically varying the pitch axis location for rigid wings and the structural stiffness for flexible wings. The results indicate that the rigid wings possess an unstable oscillatory mode mainly due to their pitch sensitivity to horizontal velocity perturbations. The flexible wings stabilize this mode primarily by adjusting their wing shape in the presence of perturbations. The wing's response to perturbations generates significantly more horizontal velocity damping and pitch rate damping than in rigid wings. Furthermore, the flexible wings experience substantially less wing wake interaction, which, for rigid wings, is destabilizing. The power required to hover a fruit fly with actively rotating rigid wings varies between 16.9 and 34.2 W/kg. The optimal power occurs when the pitch axis is located at 30% chord, similar to some biological observations. Flexible wings require 23.1 to 38.5 W/kg. However, flexible wings exhibit more stable system dynamics and

  14. The Importance of Prior Knowledge.

    Science.gov (United States)

    Cleary, Linda Miller

    1989-01-01

    Recounts a college English teacher's experience of reading and rereading Noam Chomsky, building up a greater store of prior knowledge. Argues that Frank Smith provides a theory for the importance of prior knowledge and Chomsky's work provided a personal example with which to interpret and integrate that theory. (RS)

  15. [Wing 1 radiation survey and contamination report

    International Nuclear Information System (INIS)

    Olsen, K.

    1991-01-01

    We have completed the 5480.11 survey for Wing 1. All area(s)/item(s) requested by the 5480.11 committee have been thoroughly surveyed and documented. Decontamination/disposal of contaminated items has been accomplished. The wing 1 survey was started on 8/13/90 and completed 9/18/90. However, the follow-up surveys were not completed until 2/18/91. We received the final set of smear samples for wing 1 on 1/13/91. A total of 5,495 smears were taken from wing 1 and total of 465 smears were taken during the follow-up surveys. There were a total 122 items found to have fixed contamination and 4 items with smearable contamination in excess of the limits specified in DOE ORDER 5480.11 (AR 3-7). The following area(s)/item(s) were not included in the 5480.11 survey: Hallways, Access panels, Men's and women's change rooms, Janitor closets, Wall lockers and item(s) stored in wing 1 hallways and room 1116. If our contract is renewed, we will include those areas in our survey according to your request of April 15, 1991

  16. Flapping wing aerodynamics: from insects to vertebrates.

    Science.gov (United States)

    Chin, Diana D; Lentink, David

    2016-04-01

    More than a million insects and approximately 11,000 vertebrates utilize flapping wings to fly. However, flapping flight has only been studied in a few of these species, so many challenges remain in understanding this form of locomotion. Five key aerodynamic mechanisms have been identified for insect flight. Among these is the leading edge vortex, which is a convergent solution to avoid stall for insects, bats and birds. The roles of the other mechanisms - added mass, clap and fling, rotational circulation and wing-wake interactions - have not yet been thoroughly studied in the context of vertebrate flight. Further challenges to understanding bat and bird flight are posed by the complex, dynamic wing morphologies of these species and the more turbulent airflow generated by their wings compared with that observed during insect flight. Nevertheless, three dimensionless numbers that combine key flow, morphological and kinematic parameters - the Reynolds number, Rossby number and advance ratio - govern flapping wing aerodynamics for both insects and vertebrates. These numbers can thus be used to organize an integrative framework for studying and comparing animal flapping flight. Here, we provide a roadmap for developing such a framework, highlighting the aerodynamic mechanisms that remain to be quantified and compared across species. Ultimately, incorporating complex flight maneuvers, environmental effects and developmental stages into this framework will also be essential to advancing our understanding of the biomechanics, movement ecology and evolution of animal flight. © 2016. Published by The Company of Biologists Ltd.

  17. The wings of Bombyx mori develop from larval discs exhibiting an ...

    Indian Academy of Sciences (India)

    Unknown

    and meta-thoracic discs continue to grow in size with larval age and do not display any massive cell rearrangement during metamor- phosis (compare c with d, and h with i) during the larval to pupal .... to surgery. The conspicuous absence of wing blades and presence of wound healing marks on one side are evident.

  18. Principle of bio-inspired insect wing rotational hinge design

    Science.gov (United States)

    Fei, Fan

    A principle for designing and fabricating bio-inspired miniature artificial insect flapping wing using flexure rotational hinge design is presented. A systematic approach of selecting rotational hinge stiffness value is proposed. Based on the understanding of flapping wing aerodynamics, a dynamic simulation is constructed using the established quasi-steady model and the wing design. Simulations were performed to gain insight on how different parameters affect the wing rotational response. Based on system resonance a model to predict the optimal rotational hinge stiffness based on given wing parameter and flapping wing kinematic is proposed. By varying different wing parameters, the proposed method is shown to be applicable to a wide range of wing designs with different sizes and shapes. With the selected hinge stiffness value, aspects of the rotational joint design is discussed and an integrated wing-hinge structure design using laminated carbon fiber and polymer film is presented. Manufacturing process of such composite structure is developed to achieve high accuracy and repeatability. The yielded hinge stiffness is verified by measurements. To validate the proposed model, flapping wing experiments were conducted. A flapping actuation set up is built using DC motor and a controller is implemented on a microcontroller to track desired wing stroke kinematic. Wing stroke and rotation kinematic were extracted using a high speed camera and the lift generation is evaluated. A total of 49 flapping experiments were presented, experimental data shows good correlation with the model's prediction. With the wing rotational hinge stiffness designed so that the rotational resonant frequency is twice as the stroke frequency, the resulting wing rotation generates near optimal lift. With further simulation, the proposed model shows low sensitivity to wing parameter variation. As a result, giving a design parameter of a flapping wing robot platform, the proposed principle can

  19. Gliding swifts attain laminar flow over rough wings.

    Directory of Open Access Journals (Sweden)

    David Lentink

    Full Text Available Swifts are among the most aerodynamically refined gliding birds. However, the overlapping vanes and protruding shafts of their primary feathers make swift wings remarkably rough for their size. Wing roughness height is 1-2% of chord length on the upper surface--10,000 times rougher than sailplane wings. Sailplanes depend on extreme wing smoothness to increase the area of laminar flow on the wing surface and minimize drag for extended glides. To understand why the swift does not rely on smooth wings, we used a stethoscope to map laminar flow over preserved wings in a low-turbulence wind tunnel. By combining laminar area, lift, and drag measurements, we show that average area of laminar flow on swift wings is 69% (n = 3; std 13% of their total area during glides that maximize flight distance and duration--similar to high-performance sailplanes. Our aerodynamic analysis indicates that swifts attain laminar flow over their rough wings because their wing size is comparable to the distance the air travels (after a roughness-induced perturbation before it transitions from laminar to turbulent. To interpret the function of swift wing roughness, we simulated its effect on smooth model wings using physical models. This manipulation shows that laminar flow is reduced and drag increased at high speeds. At the speeds at which swifts cruise, however, swift-like roughness prolongs laminar flow and reduces drag. This feature gives small birds with rudimentary wings an edge during the evolution of glide performance.

  20. Wing pattern variation in the Patagonian biting midge, Forcipomyia (Forcipomyia multipicta Ingram & Macfie (Diptera, Ceratopogonidae

    Directory of Open Access Journals (Sweden)

    Gustavo R. SPINELLI

    2012-01-01

    Full Text Available Examination of the type-series and non-type specimens of the Patagonian biting midge, Forcipomyia (Forcipomyia multipicta Ingram & Macfie (Diptera: Ceratopogonidae, revealed considerable variation in wing patterns of both sexes. One pattern includes several distinct light spot areas, whereas another pattern (e.g, in the holotype only features marginal light spots in cell r3, while other light spots are barely perceptible or absent. The cause(s of the differential lack of dark macrotrichia in certain areas of the wing membrane in specimens of some series could not be attributed either to their age, sex, or method of preservation.

  1. The Effect of Pitching Phase on the Vortex Circulation for a Flapping Wing During Stroke Reversal

    Science.gov (United States)

    Burge, Matthew; Ringuette, Matthew

    2017-11-01

    We study the effect of pitching-phase on the circulation behavior for the 3D flow structures produced during stroke reversal for a 2-degree-of-freedom flapping wing executing hovering kinematics. Previous research has related the choice in pitching-phase with respect to the wing rotation during stroke reversal (advanced vs. symmetric pitch-timing) to a lift peak preceding stroke reversal. However, results from experiments on the time-varying circulation contributions from the 3D vortex structures across the span produced by both rotation and pitching are lacking. The objective of this research is to quantitatively examine how the spanwise circulation of these structures is affected by the pitching-phase for several reduced pitching frequencies. We employ a scaled wing model in a glycerin-water mixture and measure the time-varying velocity using multiple planes of stereo digital particle image velocimetry. Data-plane positions along the wing span are informed by the unsteady behavior of the 3D vortex structures found in our prior flow visualization movies. Individual vortices are identified to calculate their circulation. This work is aimed at understanding how the behavior of the vortex structures created during stroke reversal vary with key motion parameters. This work is supported by the National Science Foundation, Award Number 1336548, supervised by Dr. Ronald Joslin.

  2. The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development

    Directory of Open Access Journals (Sweden)

    Zehua Wang

    2018-02-01

    Full Text Available The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types. Here, we show that the histone deacetylase HDAC1 acts as a positive regulator of Notch signaling during Drosophila wing development. Depletion of HDAC1 causes wing notches on the margin of adult wing. Consistently, the expression of Notch target genes is reduced in the absence of HDAC1 during wing margin formation. We further provide evidence that HDAC1 acts upstream of Notch activation. Mechanistically, we show that HDAC1 regulates Notch protein levels by promoting Notch transcription. Consistent with this, the HDAC1-associated transcriptional co-repressor Atrophin (Atro is also required for transcriptional activation of Notch in the wing disc. In summary, our results demonstrate that HDAC1 positively regulates Notch signaling and reveal a previously unidentified function of HDAC1 in Notch signaling.

  3. Incorporating biological prior knowledge for Bayesian learning via maximal knowledge-driven information priors.

    Science.gov (United States)

    Boluki, Shahin; Esfahani, Mohammad Shahrokh; Qian, Xiaoning; Dougherty, Edward R

    2017-12-28

    Phenotypic classification is problematic because small samples are ubiquitous; and, for these, use of prior knowledge is critical. If knowledge concerning the feature-label distribution - for instance, genetic pathways - is available, then it can be used in learning. Optimal Bayesian classification provides optimal classification under model uncertainty. It differs from classical Bayesian methods in which a classification model is assumed and prior distributions are placed on model parameters. With optimal Bayesian classification, uncertainty is treated directly on the feature-label distribution, which assures full utilization of prior knowledge and is guaranteed to outperform classical methods. The salient problem confronting optimal Bayesian classification is prior construction. In this paper, we propose a new prior construction methodology based on a general framework of constraints in the form of conditional probability statements. We call this prior the maximal knowledge-driven information prior (MKDIP). The new constraint framework is more flexible than our previous methods as it naturally handles the potential inconsistency in archived regulatory relationships and conditioning can be augmented by other knowledge, such as population statistics. We also extend the application of prior construction to a multinomial mixture model when labels are unknown, which often occurs in practice. The performance of the proposed methods is examined on two important pathway families, the mammalian cell-cycle and a set of p53-related pathways, and also on a publicly available gene expression dataset of non-small cell lung cancer when combined with the existing prior knowledge on relevant signaling pathways. The new proposed general prior construction framework extends the prior construction methodology to a more flexible framework that results in better inference when proper prior knowledge exists. Moreover, the extension of optimal Bayesian classification to multinomial

  4. The role of wing kinematics of freely flying birds downstream the wake of flapping wings

    Science.gov (United States)

    Krishnan, Krishnamoorthy; Gurka, Roi

    2016-11-01

    Avian aerodynamics has been a topic of research for centuries. Avian flight features such as flapping, morphing and maneuvering make bird aerodynamics a complex system to study, analyze and understand. Aerodynamic performance of the flapping wings can be quantified by measuring the vortex structures present in the downstream wake. Still, the direct correlation between the flapping wing kinematics and the evolution of wake features need to be established. In this present study, near wake of three bird species (western sandpiper, European starling and American robin) have been measured experimentally. Long duration, time-resolved, particle image velocimetry technique has been used to capture the wake properties. Simultaneously, the bird kinematics have been captured using high speed camera. Wake structures are reconstructed from the collected PIV images for long chord distances downstream. Wake vorticities and circulation are expressed in the wake composites. Comparison of the wake features of the three birds shows similarities and some key differences are also found. Wing tip motions of the birds are extracted for four continuous wing beat cycle to analyze the wing kinematics. Kinematic parameters of all the three birds are compared to each other and similar trends exhibited by all the birds have been observed. A correlation between the wake evolutions with the wing motion is presented. It was found that the wings' motion generates unique flow patterns at the near wake, especially at the transition phases. At these locations, a drastic change in the circulation was observed.

  5. Investigating the Force Production of Functionally-Graded Flexible Wings in Flapping Wing Flight

    Science.gov (United States)

    Mudbhari, Durlav; Erdogan, Malcolm; He, Kai; Bateman, Daniel; Lipkis, Rory; Moored, Keith

    2015-11-01

    Birds, insects and bats oscillate their wings to propel themselves over long distances and to maneuver with unprecedented agility. A key element to achieve their impressive aerodynamic performance is the flexibility of their wings. Numerous studies have shown that homogeneously flexible wings can enhance force production, propulsive efficiency and lift efficiency. Yet, animal wings are not homogenously flexible, but instead have varying material properties. The aim of this study is to characterize the force production and energetics of functionally-graded flexible wings. A partially-flexible wing composed of a rigid section and a flexible section is used as a first-order model of functionally-graded materials. The flexion occurs in the spanwise direction and it is affected by the spanwise flexion ratio, that is, the ratio of the length of the rigid section compared to the total span length. By varying the flexion ratio as well as the material properties of the flexible section, the study aims to examine the force production and energetics of flapping flight with functionally-graded flexible wings. Supported by the Office of Naval Research under Program Director Dr. Bob Brizzolara, MURI grant number N00014-14-1-0533.

  6. Aeroelastic Analysis of Modern Complex Wings

    Science.gov (United States)

    Kapania, Rakesh K.; Bhardwaj, Manoj K.; Reichenbach, Eric; Guruswamy, Guru P.

    1996-01-01

    A process is presented by which aeroelastic analysis is performed by using an advanced computational fluid dynamics (CFD) code coupled with an advanced computational structural dynamics (CSD) code. The process is demonstrated on an F/A-18 Stabilator using NASTD (an in-house McDonnell Douglas Aerospace East CFD code) coupled with NASTRAN. The process is also demonstrated on an aeroelastic research wing (ARW-2) using ENSAERO (an in-house NASA Ames Research Center CFD code) coupled with a finite element wing-box structures code. Good results have been obtained for the F/A-18 Stabilator while results for the ARW-2 supercritical wing are still being obtained.

  7. Aerodynamic improvement of a delta wing in combination with leading edge flaps

    Directory of Open Access Journals (Sweden)

    Tadateru Ishide

    2017-11-01

    Full Text Available Recently, various studies of micro air vehicle (MAV and unmanned air vehicle (UAV have been reported from wide range points of view. The aim of this study is to research the aerodynamic improvement of delta wing in low Reynold’s number region to develop an applicative these air vehicle. As an attractive tool in delta wing, leading edge flap (LEF is employed to directly modify the strength and structure of vortices originating from the separation point along the leading edge. Various configurations of LEF such as drooping apex flap and upward deflected flap are used in combination to enhance the aerodynamic characteristics in the delta wing. The fluid force measurement by six component load cell and particle image velocimetry (PIV analysis are performed as the experimental method. The relations between the aerodynamic superiority and the vortex behavior around the models are demonstrated.

  8. Enhanced expression in vivo of HLA-ABC antigens and beta 2-microglobulin on human lymphoid cells induced by human interferon-alpha in patients with lung cancer. Enhanced expression of class I major histocompatibility antigens prior to treatment

    DEFF Research Database (Denmark)

    Nissen, Mogens Holst; Plesner, T; Larsen, J K

    1985-01-01

    than 0.5, respectively) by day-to-day analysis of an untreated healthy control group. An increased expression of both HLA-ABC (mean 55%, P less than 0.0005) and beta 2m (mean 23%, P less than 0.01) was also observed prior to treatment in the lung cancer patients when compared to a group of age matched......The effect of cloned human interferon-alpha (IFN-alpha) on the expression of HLA-ABC antigens (HLA-ABC) and beta 2-microglobulin (beta 2m) on human peripheral lymphoid cells in vivo was studied by cytofluorometry using monoclonal antibodies and fluorescein-labelled rabbit anti-mouse immunoglobulin....... A significant increase in the mean fluorescence intensity of HLA-ABC (median 59%, P less than 0.001) and beta 2m (median 57%, P less than 0.001) on small lymphoid cells was observed 24 h after initiation of IFN-alpha treatment (50 X 10(6) units IFN-alpha/m2 three times a week). The enhanced expression...

  9. Active Twist Control for a Compliant Wing Structure, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Blended wing body (BWB) aircraft provide an aerodynamically superior solution over traditional tube-and-wing designs for a number of mission profiles. These...

  10. Fixed-Wing Micro Air Vehicles with Hovering Capabilities

    National Research Council Canada - National Science Library

    Bataille, Boris; Poinsot, Damien; Thipyopas, Chinnapat; Moschetta, Jean-Marc

    2007-01-01

    Fixed-wing micro air vehicles (MAV) are very attractive for outdoor surveillance missions since they generally offer better payload and endurance capabilities than rotorcraft or flapping-wing vehicles of equal size...

  11. Comparative insights into questions of lepidopteran wing pattern homology

    Directory of Open Access Journals (Sweden)

    Stockslager Steven

    2006-11-01

    Full Text Available Abstract Background Butterfly and moth eyespots can share a similar appearance, involving multiple concentric rings of colored scales, but usually occuring in non-homologous positions on the wing. Within the butterflies, on the other hand, spots that share the same homologous position may not share the concentric ring structure; and, in butterfly species that have eyespots with concentric rings, ectopic eyespots with a similar ring structure can be induced by means of a simple epidermal wound. The extent to which all these eyespots, natural or induced, share similar genes and developmental mechanisms is investigated here by means of protein in-situ localizations in selected butterfly and moth species. In addition to looking at some of the transcription factors previously identified as being involved in eyespot formation, we also tested the involvement of candidate genes from the Wingless and TGF-β signaling pathways as putative morphogens for eyespot development. Results Saturniid moth and nymphalid butterfly eyespots with concentric rings of color express at least two transcription factors, Distal-less and Engrailed, in the center of the future pattern. Nymphalid eyespots centers also express the ligand Wingless and an activated signal transducer, a phosphorylated Smad protein, but neither these proteins nor the previous two proteins are found in pierid spot centers, which consist of a single patch of color. Both butterfly wing patterns, however, express a third transcription factor, Spalt, a portion of whose expression domain maps to the black scales on the adult wing. Wounding a nymphalid wing, on the other hand, leads to upregulation of Distal-less, engrailed and spalt in subsets of cells around the wounding site, mimicking concentric eyespot development. Conclusion Wingless and TGF-β ligands are both candidate morphogens involved in nymphalid butterfly eyespot formation. These eyespots, as well as saturniid moth eyespots with concentric

  12. Nonlinear Dynamics of Wind Turbine Wings

    DEFF Research Database (Denmark)

    Larsen, Jesper Winther

    Wind turbines with a nominal effect of 5MW with a rotor diameter of up to 126m are produced today. With the increasing size wind turbines also become more and more optimized with respect to structural dimensions and material usage, without increasing the stiffness proportionally. Consequently......, large wind turbines become increasingly flexible and dynamically sensitive. This project focuses on the structural analysis of highly flexible wind turbine wings, and the aerodynamic loading of wind turbine wings under large changes in flow field due to elastic deformations and changing wind conditions....

  13. Stability and transition on swept wings

    Science.gov (United States)

    Stuckert, Greg; Herbert, Thorwald; Esfahanian, Vahid

    1993-01-01

    This paper describes the extension and application of the Parabolized Stability Equations (PSE) to the stability and transition of the supersonic three-dimensional laminar boundary layer on a swept wing. The problem formulation uses a general coordinate transformation for arbitrary curvilinear body-fitted computational grids. Some testing using these coordinates is briefly described to help validate the software used for the investigation. The disturbance amplitude ratios as a function of chord position for supersonic (Mach 1.5) boundary layers on untapered, untwisted wings of different sweep angles are then presented and compared with those obtained from local parallel analyses.

  14. Damage Considerations of a Flexible Micro Air Vehicle Wing Using 3-D Laser Vibrometry

    National Research Council Canada - National Science Library

    Mendoza, Jr, Leo L

    2007-01-01

    .... The flexible micro air vehicle wing studied was based on a University of Florida micro air vehicle wing design and was examined using measurements from the Polytec 400-3D Scanning Vibrometer. Comparisons of the wing?s natural frequencies and displacements were made between the wing?s undamaged and damaged states.

  15. Integrated multi-disciplinary design of a sailplane wing

    OpenAIRE

    Strauch, Gregory J.

    1985-01-01

    The objective of this research is to investigate the techniques and payoffs of integrated aircraft design. Lifting line theory and beam theory are used for the analysis of the aerodynamics and the structures of a composite sailplane wing. The wing is described by 33 - 34 design variables which involve the planform geometry, the twist distribution, and thicknesses of the spar caps, spar webs, and the skin at various stations along the wing. The wing design must satisfy 30 â ...

  16. Uninformative priors prefer simpler models

    Science.gov (United States)

    Mattingly, Henry; Abbott, Michael; Machta, Benjamin

    The Bayesian framework for model selection requires a prior for the probability of candidate models that is uninformative-it minimally biases predictions with preconceptions. For parameterized models, Jeffreys' uninformative prior, pJ, weights parameter space according to the local density of distinguishable model predictions. While pJ is rigorously justifiable in the limit that there is infinite data, it is ill-suited to effective theories and sloppy models. In these models, parameters are very poorly constrained by available data, and even the number of parameters is often arbitrary. We use a principled definition of `uninformative' as the mutual information between parameters and their expected data and study the properties of the prior p* which maximizes it. When data is abundant, p* approaches Jeffreys' prior. With finite data, however, p* is discrete, putting weight on a finite number of atoms in parameter space. In addition, when data is scarce, the prior lies on model boundaries, which in many cases correspond to interpretable models but with fewer parameters. As more data becomes available, the prior puts weight on models with more parameters. Thus, p* quantifies the intuition that better data can justify the use of more complex models.

  17. Use of wing morphometry for the discrimination of some Cerceris ...

    African Journals Online (AJOL)

    use

    2011-12-14

    Dec 14, 2011 ... Figure 12. Thin spline plate graphics for the species belonging to the genus Cerceris. Figure 13. Fore wing landmarks of the significant wing characteristics in the honeybee Apis mellifera. Linnaeus. stated as the traditional wing morphometry that enables the practical discrimination of the honeybee (Apis sp ...

  18. How swifts control their glide performance with morphing wings

    NARCIS (Netherlands)

    Lentink, D.; Muller, U. K.; Stamhuis, E. J.; de Kat, R.; van Gestel, W.; Veldhuis, L. L. M.; Henningsson, P.; Hedenstrom, A.; Videler, J. J.

    2007-01-01

    Gliding birds continually change the shape and size of their wings(1-6), presumably to exploit the profound effect of wing morphology on aerodynamic performance(7-9). That birds should adjust wing sweep to suit glide speed has been predicted qualitatively by analytical glide models(2,10), which

  19. Study of design parameters of flapping-wings

    NARCIS (Netherlands)

    Wang, Q.; Goosen, J.F.L.; Van Keulen, F.

    2014-01-01

    As one of the most important components of a flapping-wing micro air vehicle (FWMAV), the design of an energy-efficient flapping-wing has been a research interest recently. Research on insect flight from different perspectives has been carried out, mainly with regard to wing morphology, flapping

  20. Low Reynolds Number Wing Transients in Rotation and Translation

    Science.gov (United States)

    Jones, Anya; Schlueter, Kristy

    2012-11-01

    The unsteady aerodynamic forces and flow fields generated by a wing undergoing transient motions in both rotation and translation were investigated. An aspect ratio 2 flat plate wing at a 45 deg angle of attack was driven over 84 deg of rotation (3 chord-lengths of travel at 3/4 span) and 3 and 10 chord-lengths of translation in quiescent water at Reynolds numbers between 2,500 and 15,000. Flow visualization on the rotating wing revealed a leading edge vortex that lifted off of the wing surface, but remained in the vicinity of the wing for the duration of the wing stroke. A second spanwise vortex with strong axial flow was also observed. As the tip vortex grew, the leading edge vortex joined the tip vortex in a loop-like structure over the aft half of the wing. Near the leading edge, spanwise flow in the second vortex became entrained in the tip vortex near the corner of the wing. Unsteady force measurements revealed that lift coefficient increased through the constant-velocity portion of the wing stroke. Forces were compared for variations in wing acceleration and Reynolds number for both rotational and translational motions. The effect of tank blockage was investigated by repeating the experiments on multiple wings, varying the distance between the wing tip and tank wall. U.S. Air Force Research Laboratory, Summer Faculty Fellowship Program.

  1. Air Base Wing and Air Mobility Wing Consolidating on AMC-LED Joint Bases: A Delphi Study

    Science.gov (United States)

    2014-06-13

    AIR BASE WING AND AIR MOBILITY WING CONSOLIDATION ON AMC-LED JOINT BASES: A DELPHI STUDY GRADUATE RESEARCH PAPER Mason E. MacGarvey... DELPHI STUDY GRADUATE RESEARCH PAPER Presented to the Faculty Graduate School of Engineering Management Air Force Institute of Technology...iv AIR BASE WING AND AIR MOBILITY WING CONSOLIDATION ON AMC-LED JOINT BASES: A DELPHI STUDY Mason E. MacGarvey, BS, MBA

  2. Machine Learning for Flapping Wing Flight Control

    NARCIS (Netherlands)

    Goedhart, Menno; van Kampen, E.; Armanini, S.F.; de Visser, C.C.; Chu, Q.

    2018-01-01

    Flight control of Flapping Wing Micro Air Vehicles is challenging, because of their complex dynamics and variability due to manufacturing inconsistencies. Machine Learning algorithms can be used to tackle these challenges. A Policy Gradient algorithm is used to tune the gains of a

  3. Migration on Wings Aerodynamics and Energetics

    CERN Document Server

    Kantha, Lakshmi

    2012-01-01

    This book is an effort to explore the technical aspects associated with bird flight and migration on wings. After a short introduction on the birds migration, the book reviews the aerodynamics and Energetics of Flight and presents the calculation of the Migration Range. In addition, the authors explains aerodynamics of the formation flight and finally introduces great flight diagrams.

  4. Oblique-Flying-Wing Supersonic Transport Airplane

    Science.gov (United States)

    Van Der Velden, Alexander J. M.

    1992-01-01

    Oblique-flying-wing supersonic airplane proposed as possible alternative to B747B (or equivalent). Tranports passengers and cargo as fast as twice speed of sound at same cost as current subsonic transports. Flies at same holding speeds as present supersonic transports but requires only half takeoff distance.

  5. Chemical evaluation of winged beans ( Psophocarpus ...

    African Journals Online (AJOL)

    Chemical evaluation of winged beans ( Psophocarpus Tetragonolobus ), Pitanga cherries ( Eugenia uniflora) and orchid fruit ( Orchid fruit myristic a) ... The acid value ranged between 0.71 and 2.82 mg/KOH/g while iodine value ranged between 91.15 and 144.57. The refractive index ranged between 1.465 and 1.474 in all ...

  6. ``Schooling'' of wing pairs in flapping flight

    Science.gov (United States)

    Ramananarivo, Sophie; Zhang, Jun; Ristroph, Leif; AML, Courant Collaboration; Physics NYU Collaboration

    2015-11-01

    The experimental setup implements two independent flapping wings swimming in tandem. Both are driven with the same prescribed vertical heaving motion, but the horizontal motion is free, which means that the swimmers can take up any relative position and forward speed. Experiments show however clearly coordinated motions, where the pair of wings `crystallize' into specific stable arrangements. The follower wing locks into the path of the leader, adopting its speed, and with a separation distance that takes on one of several discrete values. By systematically varying the kinematics and wing size, we show that the set of stable spacings is dictated by the wavelength of the periodic wake structure. The forces maintaining the pair cohesion are characterized by applying an external force to the follower to perturb it away from the `stable wells'. These results show that hydrodynamics alone is sufficient to induce cohesive and coordinated collective locomotion through a fluid, and we discuss the hypothesis that fish schools and bird flocks also represent stable modes of motion.

  7. Aerodynamic comparison of a butterfly-like flapping wing-body model and a revolving-wing model

    Science.gov (United States)

    Suzuki, Kosuke; Yoshino, Masato

    2017-06-01

    The aerodynamic performance of flapping- and revolving-wing models is investigated by numerical simulations based on an immersed boundary-lattice Boltzmann method. As wing models, we use (i) a butterfly-like model with a body and flapping-rectangular wings and (ii) a revolving-wing model with the same wings as the flapping case. Firstly, we calculate aerodynamic performance factors such as the lift force, the power, and the power loading of the two models for Reynolds numbers in the range of 50-1000. For the flapping-wing model, the power loading is maximal for the maximum angle of attack of 90°, a flapping amplitude of roughly 45°, and a phase shift between the flapping angle and the angle of attack of roughly 90°. For the revolving-wing model, the power loading peaks for an angle of attack of roughly 45°. In addition, we examine the ground effect on the aerodynamic performance of the revolving-wing model. Secondly, we compare the aerodynamic performance of the flapping- and revolving-wing models at their respective maximal power loadings. It is found that the revolving-wing model is more efficient than the flapping-wing model both when the body of the latter is fixed and where it can move freely. Finally, we discuss the relative agilities of the flapping- and revolving-wing models.

  8. Paleozoic Nymphal Wing Pads Support Dual Model of Insect Wing Origins.

    Science.gov (United States)

    Prokop, Jakub; Pecharová, Martina; Nel, André; Hörnschemeyer, Thomas; Krzemińska, Ewa; Krzemiński, Wiesław; Engel, Michael S

    2017-01-23

    The appearance of wings in insects, early in their evolution [1], has been one of the more critical innovations contributing to their extraordinary diversity. Despite the conspicuousness and importance of wings, the origin of these structures has been difficult to resolve and represented one of the "abominable mysteries" in evolutionary biology [2]. More than a century of debate has boiled the matter down to two competing alternatives-one of wings representing an extension of the thoracic notum, the other stating that they are appendicular derivations from the lateral body wall. Recently, a dual model has been supported by genomic and developmental data [3-6], representing an amalgamation of elements from both the notal and pleural hypotheses. Here, we reveal crucial information from the wing pad joints of Carboniferous palaeodictyopteran insect nymphs using classical and high-tech techniques. These nymphs had three pairs of wing pads that were medially articulated to the thorax but also broadly contiguous with the notum anteriorly and posteriorly (details unobservable in modern insects), supporting their overall origin from the thoracic notum as well as the expected medial, pleural series of axillary sclerites. Our study provides support for the formation of the insect wing from the thoracic notum as well as the already known pleural elements of the arthropodan leg. These results support the unique, dual model for insect wing origins and the convergent reduction of notal fusion in more derived clades, presumably due to wing rotation during development, and they help to bring resolution to this long-standing debate. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Predator-mediated natural selection on the wings of the damselfly Calopteryx splendens: differences in selection among trait types.

    Science.gov (United States)

    Kuchta, Shawn R; Svensson, Erik I

    2014-07-01

    Traits that increase mating success in males may come at a cost, such as an increased risk of predation. However, predator-mediated selection is challenging to document in natural populations, hampering our understanding of the trade-offs between sexual selection and predation. Here we report on a study of predator-mediated natural selection on wing traits in the damselfly Calopteryx splendens, the males of which possess conspicuous wing patches. Wagtails (genus Motacilla) are important avian predators of C. splendens, capturing them in flight and removing the wings prior to consumption. Using geometric morphometric techniques, we quantified the strength and mode of selection on wing traits by comparing wings from depredated individuals with the standing variation present in the population. Our results reveal that predator-mediated selection is stronger on secondary sexual characters than on size and shape, suggesting that traits related to flight performance are closer to their adaptive peaks. This could be a consequence of the long-term evolutionary association with avian predators, whereas stronger selection on conspicuous secondary sexual traits may reflect trade-offs between sexual and natural selection. Finally, even though C. splendens possesses nearly identical fore- and hindwings, we found evidence for divergent selection between them.

  10. The Prior Internet Resources 2017

    DEFF Research Database (Denmark)

    Engerer, Volkmar Paul; Albretsen, Jørgen

    2017-01-01

    The Prior Internet Resources (PIR) are presented. Prior’s unpublished scientific manuscripts and his wast letter correspondence with fellow researchers at the time, his Nachlass, is now subject to transcription by Prior-researchers worldwide, and form an integral part of PIR. It is demonstrated...... that the PIR, defined as the virtual space delimited by the three content areas and Internet domains: 1) Priorstudies, 2) Prior Virtual Lab, and 3) Nachlass), contains six information systems of five distinct types. The informations systems are grouped into a “Transcriber Loop” to illustrate how unpublished...... material from the archive boxes goes through a transcription process to end in the Nachlass. A box taxonomy defines the transcription project’s hub. Together with the “Transcriber Loop” this setup makes it possible to use the boxlists in conjunction with a Priorbibliography also in PIR as a showcase...

  11. Composite corrugated structures for morphing wing skin applications

    International Nuclear Information System (INIS)

    Thill, C; Etches, J A; Bond, I P; Potter, K D; Weaver, P M

    2010-01-01

    Composite corrugated structures are known for their anisotropic properties. They exhibit relatively high stiffness parallel (longitudinal) to the corrugation direction and are relatively compliant in the direction perpendicular (transverse) to the corrugation. Thus, they offer a potential solution for morphing skin panels (MSPs) in the trailing edge region of a wing as a morphing control surface. In this paper, an overview of the work carried out by the present authors over the last few years on corrugated structures for morphing skin applications is first given. The second part of the paper presents recent work on the application of corrugated sandwich structures. Panels made from multiple unit cells of corrugated sandwich structures are used as MSPs in the trailing edge region of a scaled morphing aerofoil section. The aerofoil section features an internal actuation mechanism that allows chordwise length and camber change of the trailing edge region (aft 35% chord). Wind tunnel testing was carried out to demonstrate the MSP concept but also to explore its limitations. Suggestions for improvements arising from this study were deduced, one of which includes an investigation of a segmented skin. The overall results of this study show that the MSP concept exploiting corrugated sandwich structures offers a potential solution for local morphing wing skins for low speed and small air vehicles

  12. Multiple cues for winged morph production in an aphid metacommunity.

    Directory of Open Access Journals (Sweden)

    Mohsen Mehrparvar

    Full Text Available Environmental factors can lead individuals down different developmental pathways giving rise to distinct phenotypes (phenotypic plasticity. The production of winged or unwinged morphs in aphids is an example of two alternative developmental pathways. Dispersal is paramount in aphids that often have a metapopulation structure, where local subpopulations frequently go extinct, such as the specialized aphids on tansy (Tanacetum vulgare. We conducted various experiments to further understand the cues involved in the production of winged dispersal morphs by the two dominant species of the tansy aphid metacommunity, Metopeurum fuscoviride and Macrosiphoniella tanacetaria. We found that the ant-tended M. fuscoviride produced winged individuals predominantly at the beginning of the season while the untended M. tanacetaria produced winged individuals throughout the season. Winged mothers of both species produced winged offspring, although in both species winged offspring were mainly produced by unwinged females. Crowding and the presence of predators, effects already known to influence wing production in other aphid species, increased the percentage of winged offspring in M. tanacetaria, but not in M. fuscoviride. We find there are also other factors (i.e. temporal effects inducing the production of winged offspring for natural aphid populations. Our results show that the responses of each aphid species are due to multiple wing induction cues.

  13. The biomechanical origin of extreme wing allometry in hummingbirds.

    Science.gov (United States)

    Skandalis, Dimitri A; Segre, Paolo S; Bahlman, Joseph W; Groom, Derrick J E; Welch, Kenneth C; Witt, Christopher C; McGuire, Jimmy A; Dudley, Robert; Lentink, David; Altshuler, Douglas L

    2017-10-19

    Flying animals of different masses vary widely in body proportions, but the functional implications of this variation are often unclear. We address this ambiguity by developing an integrative allometric approach, which we apply here to hummingbirds to examine how the physical environment, wing morphology and stroke kinematics have contributed to the evolution of their highly specialised flight. Surprisingly, hummingbirds maintain constant wing velocity despite an order of magnitude variation in body weight; increased weight is supported solely through disproportionate increases in wing area. Conversely, wing velocity increases with body weight within species, compensating for lower relative wing area in larger individuals. By comparing inter- and intraspecific allometries, we find that the extreme wing area allometry of hummingbirds is likely an adaptation to maintain constant burst flight capacity and induced power requirements with increasing weight. Selection for relatively large wings simultaneously maximises aerial performance and minimises flight costs, which are essential elements of humming bird life history.

  14. Spatially resolved chemical analysis of cicada wings using laser-ablation electrospray ionization (LAESI) imaging mass spectrometry (IMS).

    Science.gov (United States)

    Román, Jessica K; Walsh, Callee M; Oh, Junho; Dana, Catherine E; Hong, Sungmin; Jo, Kyoo D; Alleyne, Marianne; Miljkovic, Nenad; Cropek, Donald M

    2018-03-01

    Laser-ablation electrospray ionization (LAESI) imaging mass spectrometry (IMS) is an emerging bioanalytical tool for direct imaging and analysis of biological tissues. Performing ionization in an ambient environment, this technique requires little sample preparation and no additional matrix, and can be performed on natural, uneven surfaces. When combined with optical microscopy, the investigation of biological samples by LAESI allows for spatially resolved compositional analysis. We demonstrate here the applicability of LAESI-IMS for the chemical analysis of thin, desiccated biological samples, specifically Neotibicen pruinosus cicada wings. Positive-ion LAESI-IMS accurate ion-map data was acquired from several wing cells and superimposed onto optical images allowing for compositional comparisons across areas of the wing. Various putative chemical identifications were made indicating the presence of hydrocarbons, lipids/esters, amines/amides, and sulfonated/phosphorylated compounds. With the spatial resolution capability, surprising chemical distribution patterns were observed across the cicada wing, which may assist in correlating trends in surface properties with chemical distribution. Observed ions were either (1) equally dispersed across the wing, (2) more concentrated closer to the body of the insect (proximal end), or (3) more concentrated toward the tip of the wing (distal end). These findings demonstrate LAESI-IMS as a tool for the acquisition of spatially resolved chemical information from fragile, dried insect wings. This LAESI-IMS technique has important implications for the study of functional biomaterials, where understanding the correlation between chemical composition, physical structure, and biological function is critical. Graphical abstract Positive-ion laser-ablation electrospray ionization mass spectrometry coupled with optical imaging provides a powerful tool for the spatially resolved chemical analysis of cicada wings.

  15. A phase Ib trial of continuous once-daily oral afatinib plus sirolimus in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer and/or disease progression following prior erlotinib or gefitinib.

    Science.gov (United States)

    Moran, Teresa; Palmero, Ramón; Provencio, Mariano; Insa, Amelia; Majem, Margarita; Reguart, Noemí; Bosch-Barrera, Joaquim; Isla, Dolores; Costa, Enric Carcereny; Lee, Chooi; Puig, Marta; Kraemer, Sandrine; Schnell, David; Rosell, Rafael

    2017-06-01

    Dysregulation of the downstream PI3K/AKT/mTOR signaling pathway is a proposed mechanism of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We investigated safety and antitumor activity of afatinib plus sirolimus as a potential combination to reverse acquired resistance to EGFR-TKIs in a phase IB trial in patients with EGFR mutation-positive non-small-cell lung cancer (EGFR mut NSCLC) and/or disease progression following prior erlotinib/gefitinib. Patients with EGFR mut NSCLC and/or disease progression following at least prior erlotinib/gefitinib were included in the trial. The primary endpoint was incidence of dose-limiting toxicities (DLT) to determine the maximum tolerated dose (MTD). Four initial dose cohorts were proposed to evaluate DLTs. Other endpoints included tumor response, safety, progression-free survival (PFS) and pharmacokinetics. Thirty-nine patients received afatinib and sirolimus. Additional dose cohorts were added since the second cohort (afatinib 40mg/day and sirolimus 5mg/day) was considered to have excessive toxicity. All patients experienced adverse events (AE) [grade 3: 66.7%; serious AE: 56.4%]. The most frequent AEs were diarrhea (94.9%), mucosal inflammation (64.1%), asthenia (53.8%) and rash (53.8%). Discontinuations and dose reduction due to AEs occurred in 23.1% and 25.6% of patients. MTD was determined as afatinib 30mg and sirolimus 1mg. Responses were observed in 5 patients (12.8%) [2 (5.1%) with confirmed partial response (PR); 3 (7.7%) with unconfirmed PR], and stable disease in 18 patients (46.2%). Four of the 5 responses were at doses above MTD. PFS at 6 months was estimated in 33.3% (median PFS 3.4 months). Pharmacokinetic parameters of afatinib and sirolimus were similar after single administration or in combination. The combination of afatinib and sirolimus showed lower responses than expected. Together with increased AEs and poor tolerability, this precludes clinical use and further

  16. The optimal design of UAV wing structure

    Science.gov (United States)

    Długosz, Adam; Klimek, Wiktor

    2018-01-01

    The paper presents an optimal design of UAV wing, made of composite materials. The aim of the optimization is to improve strength and stiffness together with reduction of the weight of the structure. Three different types of functionals, which depend on stress, stiffness and the total mass are defined. The paper presents an application of the in-house implementation of the evolutionary multi-objective algorithm in optimization of the UAV wing structure. Values of the functionals are calculated on the basis of results obtained from numerical simulations. Numerical FEM model, consisting of different composite materials is created. Adequacy of the numerical model is verified by results obtained from the experiment, performed on a tensile testing machine. Examples of multi-objective optimization by means of Pareto-optimal set of solutions are presented.

  17. Adjoint-based optimization for flapping wings

    Science.gov (United States)

    Xu, Min; Wei, Mingjun

    2012-11-01

    Adjoint-based methods show great potential in flow control and optimization of complex problems with high- or infinite-dimensional control space. It is attractive to solve an adjoint problem to understand the complex effects from multiple control parameters to a few performance indicators of the flight of birds or insects. However, the traditional approach to formulate the adjoint problem becomes either impossible or too complex when arbitrary moving boundary (e.g. flapping wings) and its perturbation is considered. Here, we use non-cylindrical calculus to define the perturbation. So that, a simple adjoint system can be derived directly in the inertial coordinate. The approach is first applied to the optimization of cylinder oscillation and later to flapping wings. Supported by AFOSR.

  18. Quantifying the dynamic wing morphing of hovering hummingbird.

    Science.gov (United States)

    Maeda, Masateru; Nakata, Toshiyuki; Kitamura, Ikuo; Tanaka, Hiroto; Liu, Hao

    2017-09-01

    Animal wings are lightweight and flexible; hence, during flapping flight their shapes change. It has been known that such dynamic wing morphing reduces aerodynamic cost in insects, but the consequences in vertebrate flyers, particularly birds, are not well understood. We have developed a method to reconstruct a three-dimensional wing model of a bird from the wing outline and the feather shafts (rachides). The morphological and kinematic parameters can be obtained using the wing model, and the numerical or mechanical simulations may also be carried out. To test the effectiveness of the method, we recorded the hovering flight of a hummingbird ( Amazilia amazilia ) using high-speed cameras and reconstructed the right wing. The wing shape varied substantially within a stroke cycle. Specifically, the maximum and minimum wing areas differed by 18%, presumably due to feather sliding; the wing was bent near the wrist joint, towards the upward direction and opposite to the stroke direction; positive upward camber and the 'washout' twist (monotonic decrease in the angle of incidence from the proximal to distal wing) were observed during both half-strokes; the spanwise distribution of the twist was uniform during downstroke, but an abrupt increase near the wrist joint was found during upstroke.

  19. Optimization of aerodynamic efficiency for twist morphing MAV wing

    Directory of Open Access Journals (Sweden)

    N.I. Ismail

    2014-06-01

    Full Text Available Twist morphing (TM is a practical control technique in micro air vehicle (MAV flight. However, TM wing has a lower aerodynamic efficiency (CL/CD compared to membrane and rigid wing. This is due to massive drag penalty created on TM wing, which had overwhelmed the successive increase in its lift generation. Therefore, further CL/CDmax optimization on TM wing is needed to obtain the optimal condition for the morphing wing configuration. In this paper, two-way fluid–structure interaction (FSI simulation and wind tunnel testing method are used to solve and study the basic wing aerodynamic performance over (non-optimal TM, membrane and rigid wings. Then, a multifidelity data metamodel based design optimization (MBDO process is adopted based on the Ansys-DesignXplorer frameworks. In the adaptive MBDO process, Kriging metamodel is used to construct the final multifidelity CL/CD responses by utilizing 23 multi-fidelity sample points from the FSI simulation and experimental data. The optimization results show that the optimal TM wing configuration is able to produce better CL/CDmax magnitude by at least 2% than the non-optimal TM wings. The flow structure formation reveals that low TV strength on the optimal TM wing induces low CD generation which in turn improves its overall CL/CDmax performance.

  20. An experimental test of the impact of style and rhetoric on the perception of right-wing populist and mainstream party leaders

    NARCIS (Netherlands)

    Bos, L.; van der Brug, W.; de Vreese, C.H.

    2013-01-01

    It has often been argued that the communication strategies used by right-wing populists are key to their appeal to voters. However, prior studies found only rather limited across-the-board effects of communication strategies that employ a populist style and rhetoric. In this study, we focus on the

  1. A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.

    Science.gov (United States)

    Lee, Yu-Chin; Ho, Ching-Liang; Kao, Woei-Yau; Chen, Yuh-Min

    2015-11-01

    Antroquinonol is isolated from Antrodia camphorata , a camphor tree mushroom, and is a valuable traditional Chinese herbal medicine that exhibits pharmacological activities against several diseases, including cancer. This first-in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer who had received at least two prior systemic treatment regimens. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolerable dose (MTD), dose-limiting toxicities (DLTs), and safety/tolerability and preliminary efficacy profiles of antroquinonol. The patients received escalating doses of once-daily antroquinonol in 4-week cycles (up to 3 cycles). The escalated doses were 50-600 mg. PKs were evaluated on day 1 and 28 of cycle 1. Between January, 2011 and October, 2012, 13 patients with metastatic adenocarcinoma were enrolled. No DLTs occurred in any patient at any dose level. T max was observed between 1.00 and 3.70 h under single-dose conditions, and at 1.92-4.05 h under multiple-dose conditions. The mean elimination half-life ranged between 1.30 and 4.33 h, independent of the treatment dose. Antroquinonol at all dose levels had a mild toxicity profile, with no reported treatment-related mortality. The most common treatment-related adverse events were diarrhea, vomiting and nausea. The best tumor response was stable disease in 3 patients. In conclusion, antroquinonol at all dose levels, administered daily for 4 weeks, was generally safe and well tolerated, without DLTs. The recommended dose level for a phase II study is ≥600 mg daily.

  2. Iron chelation treatment with deferasirox prior to high-dose chemotherapy and autologous stem cell transplantation may reduce the risk of hepatic veno-occlusive disease in children with high-risk solid tumors.

    Science.gov (United States)

    Chueh, Hee Won; Sung, Ki Woong; Lee, Soo Hyun; Yoo, Keon Hee; Koo, Hong Hoe; Kim, Ju Youn; Cho, Eun Joo

    2012-03-01

    We evaluated whether iron chelation treatment during induction chemotherapy could safely reduce serum iron levels and thereby reduce the frequency of hepatic veno-occlusive disease (VOD) during high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in children with high-risk solid tumors. Children diagnosed with high-risk solid tumors between August 2008 and July 2009 were enrolled. Deferasirox treatment (25 mg/kg/day) was initiated when serum ferritin levels increased to more than 1,000 ng/ml during induction chemotherapy. Patients who were diagnosed with the same disease between April 2005 and June 2007 and treated in the same way without any iron chelation treatment formed the control group. Efficacy and toxicity of deferasirox treatment were compared between the two groups. Eighteen of 20 patients enrolled received deferasirox treatment. Deferasirox treatment was completed as scheduled in 11 (61.1%) of them without dose reduction or discontinuation. The serum ferritin levels prior to HDCT/autoSCT were lower in the deferasirox group than in the control group (median 1,268 ng/ml vs. 1,828 ng/ml, P deferasirox group (P = 0.005). However, renal dysfunction (38.9%) including Fanconi syndrome (16.7%) was a frequently observed adverse effect of deferasirox treatment. Deferasirox treatment during induction chemotherapy reduces the frequency of VOD during HDCT/autoSCT. The development of renal dysfunction should be closely monitored during deferasirox treatment. Copyright © 2011 Wiley Periodicals, Inc.

  3. Logistics Supply of the Distributed Air Wing

    Science.gov (United States)

    2014-09-01

    Event Graph The Consumption Process first instantiates the variables . The model follows a conveyor belt pattern, whereby after processing an event...to any part of the world. A capstone project, conducted by the system engineering curriculum, proposed to distribute the air assets from the aircraft...SUBJECT TERMS distributed air wing, logistics, supply, unmanned air systems , cargo UAS, unmanned systems , discrete event simulation, vehicle routing

  4. CFD Analysis of UAV Flying Wing

    Directory of Open Access Journals (Sweden)

    Vasile PRISACARIU

    2016-09-01

    Full Text Available Numerical methods for solving equations describing the evolution of 3D fluid experienced a significant development closely related to the progress of information systems. Today, especially in the field of fluid mechanics, numerical simulations allow the study of gas-thermodynamic confirmed by experimental techniques in wind tunnel conditions and actual flight tests for modeling complex aircraft. The article shows a case of numerical analysis of the lifting surface on the UAV type flying wing.

  5. Topology Optimization of an Aircraft Wing

    Science.gov (United States)

    2015-06-11

    can combine the advantages of a variable stiffness design with- out the use of actuators. Curved beams, which couple torsion and bending , counteract... torsional deflection, control natural frequency, exploit coupling of bending and tor- sion to control flutter, reduce thickness to chord ratios due to...disregarded any bending or torsional effects caused by displacement of the wing, and was thus not considered. Therefore, the initial design analysis

  6. Quantum steganography using prior entanglement

    Energy Technology Data Exchange (ETDEWEB)

    Mihara, Takashi, E-mail: mihara@toyo.jp

    2015-06-05

    Steganography is the hiding of secret information within innocent-looking information (e.g., text, audio, image, video, etc.). A quantum version of steganography is a method based on quantum physics. In this paper, we propose quantum steganography by combining quantum error-correcting codes with prior entanglement. In many steganographic techniques, embedding secret messages in error-correcting codes may cause damage to them if the embedded part is corrupted. However, our proposed steganography can separately create secret messages and the content of cover messages. The intrinsic form of the cover message does not have to be modified for embedding secret messages. - Highlights: • Our steganography combines quantum error-correcting codes with prior entanglement. • Our steganography can separately create secret messages and the content of cover messages. • Errors in cover messages do not have affect the recovery of secret messages. • We embed a secret message in the Steane code as an example of our steganography.

  7. Quantum steganography using prior entanglement

    International Nuclear Information System (INIS)

    Mihara, Takashi

    2015-01-01

    Steganography is the hiding of secret information within innocent-looking information (e.g., text, audio, image, video, etc.). A quantum version of steganography is a method based on quantum physics. In this paper, we propose quantum steganography by combining quantum error-correcting codes with prior entanglement. In many steganographic techniques, embedding secret messages in error-correcting codes may cause damage to them if the embedded part is corrupted. However, our proposed steganography can separately create secret messages and the content of cover messages. The intrinsic form of the cover message does not have to be modified for embedding secret messages. - Highlights: • Our steganography combines quantum error-correcting codes with prior entanglement. • Our steganography can separately create secret messages and the content of cover messages. • Errors in cover messages do not have affect the recovery of secret messages. • We embed a secret message in the Steane code as an example of our steganography

  8. Prior information in structure estimation

    Czech Academy of Sciences Publication Activity Database

    Kárný, Miroslav; Nedoma, Petr; Khailova, Natalia; Pavelková, Lenka

    2003-01-01

    Roč. 150, č. 6 (2003), s. 643-653 ISSN 1350-2379 R&D Projects: GA AV ČR IBS1075102; GA AV ČR IBS1075351; GA ČR GA102/03/0049 Institutional research plan: CEZ:AV0Z1075907 Keywords : prior knowledge * structure estimation * autoregressive models Subject RIV: BC - Control Systems Theory Impact factor: 0.745, year: 2003 http://library.utia.cas.cz/separaty/historie/karny-0411258.pdf

  9. Tracing the evolution of avian wing digits.

    Science.gov (United States)

    Xu, Xing; Mackem, Susan

    2013-06-17

    It is widely accepted that birds are a subgroup of dinosaurs, but there is an apparent conflict: modern birds have been thought to possess only the middle three fingers (digits II-III-IV) of an idealized five-digit tetrapod hand based on embryological data, but their Mesozoic tetanuran dinosaur ancestors are considered to have the first three digits (I-II-III) based on fossil evidence. How could such an evolutionary quirk arise? Various hypotheses have been proposed to resolve this paradox. Adding to the confusion, some recent developmental studies support a I-II-III designation for avian wing digits whereas some recent paleontological data are consistent with a II-III-IV identification of the Mesozoic tetanuran digits. A comprehensive analysis of both paleontological and developmental data suggests that the evolution of the avian wing digits may have been driven by homeotic transformations of digit identity, which are more likely to have occurred in a partial and piecemeal manner. Additionally, recent genetic studies in mouse models showing plausible mechanisms for central digit loss invite consideration of new alternative possibilities (I-II-IV or I-III-IV) for the homologies of avian wing digits. While much progress has been made, some advances point to the complexity of the problem and a final resolution to this ongoing debate demands additional work from both paleontological and developmental perspectives, which will surely yield new insights on mechanisms of evolutionary adaptation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Unsteady fluid dynamics around a hovering wing

    Science.gov (United States)

    Krishna, Swathi; Green, Melissa; Mulleners, Karen

    2017-11-01

    The unsteady flow around a hovering flat plate wing has been investigated experimentally using particle image velocimetry and direct force measurements. The measurements are conducted on a wing that rotates symmetrically about the stroke reversal at a reduced frequency of k = 0.32 and Reynolds number of Re = 220 . The Lagrangian finite-time Lyapunov exponent method is used to analyse the unsteady flow fields by identifying dynamically relevant flow features such as the primary leading edge vortex (LEV), secondary vortices, and topological saddles, and their evolution within a flapping cycle. The flow evolution is divided into four stages that are characterised by the LEV (a)emergence, (b)growth, (c)lift-off, and (d)breakdown and decay. Tracking saddle points is shown to be helpful in defining the LEV lift-off which occurs at the maximum stroke velocity. The flow fields are correlated with the aerodynamic forces revealing that the maximum lift and drag are observed just before LEV lift-off. The end of wing rotation in the beginning of the stroke stimulates a change in the direction of the LEV growth and the start of rotation at the end of the stroke triggers the breakdown of the LEV.

  11. Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension.

    Science.gov (United States)

    Tsoumpekos, Giorgos; Nemetschke, Linda; Knust, Elisabeth

    2018-03-05

    Growth of epithelial tissues is regulated by a plethora of components, including signaling and scaffolding proteins, but also by junctional tension, mediated by the actomyosin cytoskeleton. However, how these players are spatially organized and functionally coordinated is not well understood. Here, we identify the Drosophila melanogaster scaffolding protein Big bang as a novel regulator of growth in epithelial cells of the wing disc by ensuring proper junctional tension. Loss of big bang results in the reduction of the regulatory light chain of nonmuscle myosin, Spaghetti squash. This is associated with an increased apical cell surface, decreased junctional tension, and smaller wings. Strikingly, these phenotypic traits of big bang mutant discs can be rescued by expressing constitutively active Spaghetti squash. Big bang colocalizes with Spaghetti squash in the apical cytocortex and is found in the same protein complex. These results suggest that in epithelial cells of developing wings, the scaffolding protein Big bang controls apical cytocortex organization, which is important for regulating cell shape and tissue growth. © 2018 Tsoumpekos et al.

  12. Butterfly Wings Are Three-Dimensional: Pupal Cuticle Focal Spots and Their Associated Structures in Junonia Butterflies.

    Science.gov (United States)

    Taira, Wataru; Otaki, Joji M

    2016-01-01

    Butterfly wing color patterns often contain eyespots, which are developmentally determined at the late larval and early pupal stages by organizing activities of focal cells that can later form eyespot foci. In the pupal stage, the focal position of a future eyespot is often marked by a focal spot, one of the pupal cuticle spots, on the pupal surface. Here, we examined the possible relationships of the pupal focal spots with the underneath pupal wing tissues and with the adult wing eyespots using Junonia butterflies. Large pupal focal spots were found in two species with large adult eyespots, J. orithya and J. almana, whereas only small pupal focal spots were found in a species with small adult eyespots, J. hedonia. The size of five pupal focal spots on a single wing was correlated with the size of the corresponding adult eyespots in J. orithya. A pupal focal spot was a three-dimensional bulge of cuticle surface, and the underside of the major pupal focal spot exhibited a hollowed cuticle in a pupal case. Cross sections of a pupal wing revealed that the cuticle layer shows a curvature at a focal spot, and a positional correlation was observed between the cuticle layer thickness and its corresponding cell layer thickness. Adult major eyespots of J. orithya and J. almana exhibited surface elevations and depressions that approximately correspond to the coloration within an eyespot. Our results suggest that a pupal focal spot is produced by the organizing activity of focal cells underneath the focal spot. Probably because the focal cell layer immediately underneath a focal spot is thicker than that of its surrounding areas, eyespots of adult butterfly wings are three-dimensionally constructed. The color-height relationship in adult eyespots might have an implication in the developmental signaling for determining the eyespot color patterns.

  13. Wing geometry of Triatoma sordida (Hemiptera: Reduviidae) populations from Brazil.

    Science.gov (United States)

    Vendrami, Daniel Pagotto; Obara, Marcos Takashi; Gurgel-Gonçalves, Rodrigo; Ceretti-Junior, Walter; Marrelli, Mauro Toledo

    2017-04-01

    Triatoma sordida has a widespread distribution in Argentina, Bolivia, Brazil, Paraguay, and Uruguay and is frequently found in peridomestic environments. We investigated size and shape variability of T. sordida wings across Brazil. Field-collected adults from twelve populations were studied. For each individual female, seven landmarks on the right wing were digitalized. Shape variables derived from Procrustes superimposition were used in Principal Component Analysis (PCA). Wing size and shape variations among populations was explored by means of ANOVA. Wing centroid size was significantly different among T. sordida populations; specimens from Bahia (East) were larger than those of Mato Grosso do Sul (West). PCA based on wing shape variables showed low wing shape variability. These results reinforce previous data showing low genetic variability among T. sordida populations from Brazil. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Measurement of shape and deformation of insect wing

    Science.gov (United States)

    Yin, Duo; Wei, Zhen; Wang, Zeyu; Zhou, Changqiu

    2018-01-01

    To measure the shape and deformation of an insect wing, a scanning setup adopting laser triangulation and image matching was developed. Only one industry camera with two light sources was employed to scan the transparent insect wings. 3D shape and point to point full field deformation of the wings could be obtained even when the wingspan is less than 3 mm. The venation and corrugation could be significantly identified from the results. The deformation of the wing under pin loading could be seen clearly from the results as well. Calibration shows that the shape and deformation measurement accuracies are no lower than 0.01 mm. Laser triangulation and image matching were combined dexterously to adapt wings' complex shape, size, and transparency. It is suitable for insect flight research or flapping wing micro-air vehicle development.

  15. Free vibration analysis of dragonfly wings using finite element method

    OpenAIRE

    M Darvizeh; A Darvizeh; H Rajabi; A Rezaei

    2016-01-01

    In the present work, investigations on the microstructure and mechanicalproperties of the dragonfly wing are carried out and numerical modelingbased on Finite Element Method (FEM) is developed to predict Flightcharacteristics of dragonfly wings. Vibrational behavior of wings typestructures is immensely important in analysis, design and manufacturing ofsimilar engineering structures. For this purpose natural frequencies andmode shapes are calculated. In addition, the kind of deformation in eac...

  16. Investigation and design of a C-Wing passenger aircraft

    Directory of Open Access Journals (Sweden)

    Karan BIKKANNAVAR

    2016-06-01

    Full Text Available A novel nonplanar wing concept called C-Wing is studied and implemented on a commercial aircraft to reduce induced drag which has a significant effect on fuel consumption. A preliminary sizing method which employs an optimization algorithm is utilized. The Airbus A320 aircraft is used as a reference aircraft to evaluate design parameters and to investigate the C-Wing design potential beyond current wing tip designs. An increase in aspect ratio due to wing area reduction at 36m span results in a reduction of required fuel mass by 16%. Also take-off mass savings were obtained for the aircraft with C-Wing configuration. The effect of a variations of height to span ratio (h/b of C-Wings on induced drag factor k, is formulated from a vortex lattice method and literature based equations. Finally the DOC costing methods used by the Association of European Airlines (AEA was applied to the existing A320 aircraft and to the C-Wing configuration obtaining a reduction of 6% in Direct Operating Costs (DOC for the novel concept resulted. From overall outcomes, the C-Wing concept suggests interesting aerodynamic efficiency and stability benefits.

  17. Effects of Canard on the Flowfield over a Wing

    Science.gov (United States)

    Nayebzadeh, Arash

    2015-11-01

    Surface and flowfield pressure measurements have been done over delta wing/canard configuration in a variety of canard vertical and horizontal locations and angles of attack. The experimental model consisted of wing, canard and a body to accommodate pressure tubing and canard rotation mechanism. All the tests have been performed at subsonic velocities and the effect of canard were analyzed through comparison between surface and flowfield pressure distributions. It was found that vortex flow pattern over the wing is dominated mainly by canard vertical position and in some cases, by merging of canard and wing vortices. In addition, the pressure loss induced by canard vortex on the wing surface moves the wing vortex toward the leading edge. In the mid canard configuration, canard and wing vortices merge at x/c greater than 0.5 and as a result of this phenomenon, abrupt pressure loss induces more stable vortex flow over the wing. It is also shown that canard plays a vital role in vortex break down over the wing.

  18. Improvement of the aerodynamic performance by wing flexibility and elytra–hind wing interaction of a beetle during forward flight

    Science.gov (United States)

    Le, Tuyen Quang; Truong, Tien Van; Park, Soo Hyung; Quang Truong, Tri; Ko, Jin Hwan; Park, Hoon Cheol; Byun, Doyoung

    2013-01-01

    In this work, the aerodynamic performance of beetle wing in free-forward flight was explored by a three-dimensional computational fluid dynamics (CFDs) simulation with measured wing kinematics. It is shown from the CFD results that twist and camber variation, which represent the wing flexibility, are most important when determining the aerodynamic performance. Twisting wing significantly increased the mean lift and camber variation enhanced the mean thrust while the required power was lower than the case when neither was considered. Thus, in a comparison of the power economy among rigid, twisting and flexible models, the flexible model showed the best performance. When the positive effect of wing interaction was added to that of wing flexibility, we found that the elytron created enough lift to support its weight, and the total lift (48.4 mN) generated from the simulation exceeded the gravity force of the beetle (47.5 mN) during forward flight. PMID:23740486

  19. Photo-elastic properties of the wing imaginal disc of Drosophila

    OpenAIRE

    Schluck, T; Aegerter, C M

    2010-01-01

    In the study of developmental biology, the physical properties and constraints of the developing tissues are of great importance. In spite of this, not much is known about the elastic properties of biologically relevant tissues that are studied in biology labs. Here, we characterize properties of the wing imaginal disc of Drosophila, which is a precursor organ intensely studied in the framework of growth control and cell polarity. In order to determine the possibility of measuring mechanical ...

  20. Correspondence propagation with weak priors.

    Science.gov (United States)

    Wang, Huan; Yan, Shuicheng; Liu, Jianzhuang; Tang, Xiaoou; Huang, Thomas S

    2009-01-01

    For the problem of image registration, the top few reliable correspondences are often relatively easy to obtain, while the overall matching accuracy may fall drastically as the desired correspondence number increases. In this paper, we present an efficient feature matching algorithm to employ sparse reliable correspondence priors for piloting the feature matching process. First, the feature geometric relationship within individual image is encoded as a spatial graph, and the pairwise feature similarity is expressed as a bipartite similarity graph between two feature sets; then the geometric neighborhood of the pairwise assignment is represented by a categorical product graph, along which the reliable correspondences are propagated; and finally a closed-form solution for feature matching is deduced by ensuring the feature geometric coherency as well as pairwise feature agreements. Furthermore, our algorithm is naturally applicable for incorporating manual correspondence priors for semi-supervised feature matching. Extensive experiments on both toy examples and real-world applications demonstrate the superiority of our algorithm over the state-of-the-art feature matching techniques.

  1. Folding wings like a cockroach: a review of transverse wing folding ensign wasps (Hymenoptera: Evaniidae: Afrevania and Trissevania.

    Directory of Open Access Journals (Sweden)

    István Mikó

    Full Text Available We revise two relatively rare ensign wasp genera, whose species are restricted to Sub-Saharan Africa: Afrevania and Trissevania. Afrevania longipetiolata sp. nov., Trissevania heatherae sp. nov., T. hugoi sp. nov., T. mrimaensis sp. nov. and T. slideri sp. nov. are described, males and females of T. anemotis and Afrevania leroyi are redescribed, and an identification key for Trissevaniini is provided. We argue that Trissevania mrimaensis sp. nov. and T. heatherae sp. nov. populations are vulnerable, given their limited distributions and threats from mining activities in Kenya. We hypothesize that these taxa together comprise a monophyletic lineage, Trissevaniini, tr. nov., the members of which share the ability to fold their fore wings along two intersecting fold lines. Although wing folding of this type has been described for the hind wing of some insects four-plane wing folding of the fore wing has never been documented. The wing folding mechanism and the pattern of wing folds of Trissevaniini is shared only with some cockroach species (Blattodea. It is an interesting coincidence that all evaniids are predators of cockroach eggs. The major wing fold lines of Trissevaniini likely are not homologous to any known longitudinal anatomical structures on the wings of other Evaniidae. Members of the new tribe share the presence of a coupling mechanism between the fore wing and the mesosoma that is composed of a setal patch on the mesosoma and the retinaculum of the fore wing. While the setal patch is an evolutionary novelty, the retinaculum, which originally evolved to facilitate fore and hind wing coupling in Hymenoptera, exemplifies morphological exaptation. We also refine and clarify the Semantic Phenotype approach used in previous taxonomic revisions and explore the consequences of merging new with existing data. The way that semantic statements are formulated can evolve in parallel, alongside improvements to the ontologies themselves.

  2. Cantilever Wings for Modern Aircraft: Some Aspects of Cantilever Wing Construction with Special Reference to Weight and Torsional Stiffness

    Science.gov (United States)

    Stieger, H J

    1929-01-01

    In the foregoing remarks I have made an attempt to touch on some of the structural problems met with in cantilever wings, and dealt rather fully with a certain type of single-spar construction. The experimental test wing was a first attempt to demonstrate the principles of this departure from orthodox methods. The result was a wing both torsionally stiff and of light weight - lighter than a corresponding biplane construction.

  3. Serological and genetic characterisation of bovine respiratory syncytial virus (BRSV) indicates that Danish isolates belong to the intermediate subgroup: no evidence of a selective effect on the variability of G protein nucleotide sequence by prior cell culture adaption and passages in cell culture

    DEFF Research Database (Denmark)

    Larsen, Lars Erik; Uttenthal, Åse; Arctander, P.

    1998-01-01

    , respectively. Phylogenetic analysis showed that the Danish isolates formed three lineages within a separate branch of the phylogenetic tree. Nevertheless, the Danish isolates were closely related to the 220-69Bel isolate, the prototype of the intermediate antigenic subgroup. The sequencing of the extracellular...... part of the G gene of additional 11 field BRSV viruses, processed directly from lung samples without prior adaption to cell culture growth. revealed sequence variabilities in the range obtained with the propagated virus. In addition, several passages in cell culture and in calves had no major impact...... on the nucleotide sequence of the G protein. These findings indicated that the previously established variabilities of the G protein of RS virus isolates were not attributable to mutations induced during the propagation of the virus. The reactivity of the Danish isolates with G protein-specific MAbs were similar...

  4. Demonstration of an in situ morphing hyperelliptical cambered span wing mechanism

    International Nuclear Information System (INIS)

    Manzo, Justin; Garcia, Ephrahim

    2010-01-01

    Research on efficient shore bird morphology inspired the hyperelliptical cambered span (HECS) wing, a crescent-shaped, aft-swept wing with vertically oriented wingtips. The wing reduces vorticity-induced circulation loss and outperforms an elliptical baseline when planar. Designed initially as a rigid wing, the HECS wing makes use of morphing to transition from a planar to a furled configuration, similar to that of a continuously curved winglet, in flight. A morphing wing concept mechanism is presented, employing shape memory alloy actuators to create a discretized curvature approximation. The aerodynamics for continuous wing shapes is validated quasi-statically through wind tunnel testing, showing enhanced planar HECS wing lift-to-drag performance over an elliptical wing, with the furled HECS wing showing minimal enhancements beyond this point. Wind tunnel tests of the active morphing wing prove the mechanism capable of overcoming realistic loading, while further testing may be required to establish aerodynamic merits of the HECS wing morphing maneuver

  5. Biomechanics of smart wings in a bat robot: morphing wings using SMA actuators

    International Nuclear Information System (INIS)

    Colorado, J; Barrientos, A; Rossi, C; Breuer, K S

    2012-01-01

    This paper presents the design of a bat-like micro aerial vehicle with actuated morphing wings. NiTi shape memory alloys (SMAs) acting as artificial biceps and triceps muscles are used for mimicking the morphing wing mechanism of the bat flight apparatus. Our objective is twofold. Firstly, we have implemented a control architecture that allows an accurate and fast SMA actuation. This control makes use of the electrical resistance measurements of SMAs to adjust morphing wing motions. Secondly, the feasibility of using SMA actuation technology is evaluated for the application at hand. To this purpose, experiments are conducted to analyze the control performance in terms of nominal and overloaded operation modes of the SMAs. This analysis includes: (i) inertial forces regarding the stretchable wing membrane and aerodynamic loads, and (ii) uncertainties due to impact of airflow conditions over the resistance–motion relationship of SMAs. With the proposed control, morphing actuation speed can be increased up to 2.5 Hz, being sufficient to generate lift forces at a cruising speed of 5 m s −1 . (paper)

  6. Biomechanics of smart wings in a bat robot: morphing wings using SMA actuators.

    Science.gov (United States)

    Colorado, J; Barrientos, A; Rossi, C; Bahlman, J W; Breuer, K S

    2012-09-01

    This paper presents the design of a bat-like micro aerial vehicle with actuated morphing wings. NiTi shape memory alloys (SMAs) acting as artificial biceps and triceps muscles are used for mimicking the morphing wing mechanism of the bat flight apparatus. Our objective is twofold. Firstly, we have implemented a control architecture that allows an accurate and fast SMA actuation. This control makes use of the electrical resistance measurements of SMAs to adjust morphing wing motions. Secondly, the feasibility of using SMA actuation technology is evaluated for the application at hand. To this purpose, experiments are conducted to analyze the control performance in terms of nominal and overloaded operation modes of the SMAs. This analysis includes: (i) inertial forces regarding the stretchable wing membrane and aerodynamic loads, and (ii) uncertainties due to impact of airflow conditions over the resistance-motion relationship of SMAs. With the proposed control, morphing actuation speed can be increased up to 2.5 Hz, being sufficient to generate lift forces at a cruising speed of 5 m s(-1).

  7. A parametric wing design study for a modern laminar flow wing

    Science.gov (United States)

    Koegler, J. A., Jr.

    1979-01-01

    The results of a parametric wing design study using a modern laminar flow airfoil designed to exhibit desirable stall characteristics while maintaining high cruise performance are presented. It was found that little is sacrificed in cruise performance when satisfying the stall margin requirements if a taper ratio of 0.65 or greater is used.

  8. SUPERDENSE MASSIVE GALAXIES IN WINGS LOCAL CLUSTERS

    International Nuclear Information System (INIS)

    Valentinuzzi, T.; D'Onofrio, M.; Fritz, J.; Poggianti, B. M.; Bettoni, D.; Fasano, G.; Moretti, A.; Omizzolo, A.; Varela, J.; Cava, A.; Couch, W. J.; Dressler, A.; Moles, M.; Kjaergaard, P.; Vanzella, E.

    2010-01-01

    Massive quiescent galaxies at z > 1 have been found to have small physical sizes, and hence to be superdense. Several mechanisms, including minor mergers, have been proposed for increasing galaxy sizes from high- to low-z. We search for superdense massive galaxies in the WIde-field Nearby Galaxy-cluster Survey (WINGS) of X-ray selected galaxy clusters at 0.04 10 M sun , are mostly S0 galaxies, have a median effective radius (R e ) = 1.61 ± 0.29 kpc, a median Sersic index (n) = 3.0 ± 0.6, and very old stellar populations with a median mass-weighted age of 12.1 ± 1.3 Gyr. We calculate a number density of 2.9 x 10 -2 Mpc -3 for superdense galaxies in local clusters, and a hard lower limit of 1.3 x 10 -5 Mpc -3 in the whole comoving volume between z = 0.04 and z = 0.07. We find a relation between mass, effective radius, and luminosity-weighted age in our cluster galaxies, which can mimic the claimed evolution of the radius with redshift, if not properly taken into account. We compare our data with spectroscopic high-z surveys and find that-when stellar masses are considered-there is consistency with the local WINGS galaxy sizes out to z ∼ 2, while a discrepancy of a factor of 3 exists with the only spectroscopic z > 2 study. In contrast, there is strong evidence for a large evolution in radius for the most massive galaxies with M * > 4 x 10 11 M sun compared to similarly massive galaxies in WINGS, i.e., the brightest cluster galaxies.

  9. Effects of boundary layer forcing on wing-tip vortices

    Science.gov (United States)

    Shaw-Ward, Samantha

    The nature of turbulence within wing-tip vortices has been a topic of research for decades, yet accurate measurements of Reynolds stresses within the core are inherently difficult due to the bulk motion wandering caused by initial and boundary conditions in wind tunnels. As a result, characterization of a vortex as laminar or turbulent is inconclusive and highly contradicting. This research uses several experimental techniques to study the effects of broadband turbulence, introduced within the wing boundary layer, on the development of wing-tip vortices. Two rectangular wings with a NACA 0012 profile were fabricated for the use of this research. One wing had a smooth finish and the other rough, introduced by P80 grade sandpaper. Force balance measurements showed a small reduction in wing performance due to surface roughness for both 2D and 3D configurations, although stall characteristics remained relatively unchanged. Seven-hole probes were purpose-built and used to assess the mean velocity profiles of the vortices five chord lengths downstream of the wing at multiple angles of attack. Above an incidence of 4 degrees, the vortices were nearly axisymmetric, and the wing roughness reduced both velocity gradients and peak velocity magnitudes within the vortex. Laser Doppler velocimetry was used to further assess the time-resolved vortex at an incidence of 5 degrees. Evidence of wake shedding frequencies and wing shear layer instabilities at higher frequencies were seen in power spectra within the vortex. Unlike the introduction of freestream turbulence, wing surface roughness did not appear to increase wandering amplitude. A new method for removing the effects of vortex wandering is proposed with the use of carefully selected high-pass filters. The filtered data revealed that the Reynolds stress profiles of the vortex produced by the smooth and rough wing were similar in shape, with a peak occurring away from the vortex centre but inside of the core. Single hot

  10. Folding in and out: passive morphing in flapping wings.

    Science.gov (United States)

    Stowers, Amanda K; Lentink, David

    2015-03-25

    We present a new mechanism for passive wing morphing of flapping wings inspired by bat and bird wing morphology. The mechanism consists of an unactuated hand wing connected to the arm wing with a wrist joint. Flapping motion generates centrifugal accelerations in the hand wing, forcing it to unfold passively. Using a robotic model in hover, we made kinematic measurements of unfolding kinematics as functions of the non-dimensional wingspan fold ratio (2-2.5) and flapping frequency (5-17 Hz) using stereo high-speed cameras. We find that the wings unfold passively within one to two flaps and remain unfolded with only small amplitude oscillations. To better understand the passive dynamics, we constructed a computer model of the unfolding process based on rigid body dynamics, contact models, and aerodynamic correlations. This model predicts the measured passive unfolding within about one flap and shows that unfolding is driven by centrifugal acceleration induced by flapping. The simulations also predict that relative unfolding time only weakly depends on flapping frequency and can be reduced to less than half a wingbeat by increasing flapping amplitude. Subsequent dimensional analysis shows that the time required to unfold passively is of the same order of magnitude as the flapping period. This suggests that centrifugal acceleration can drive passive unfolding within approximately one wingbeat in small and large wings. Finally, we show experimentally that passive unfolding wings can withstand impact with a branch, by first folding and then unfolding passively. This mechanism enables flapping robots to squeeze through clutter without sophisticated control. Passive unfolding also provides a new avenue in morphing wing design that makes future flapping morphing wings possibly more energy efficient and light-weight. Simultaneously these results point to possible inertia driven, and therefore metabolically efficient, control strategies in bats and birds to morph or recover

  11. Video change detection for fixed wing UAVs

    Science.gov (United States)

    Bartelsen, Jan; Müller, Thomas; Ring, Jochen; Mück, Klaus; Brüstle, Stefan; Erdnüß, Bastian; Lutz, Bastian; Herbst, Theresa

    2017-10-01

    In this paper we proceed the work of Bartelsen et al.1 We present the draft of a process chain for an image based change detection which is designed for videos acquired by fixed wing unmanned aerial vehicles (UAVs). From our point of view, automatic video change detection for aerial images can be useful to recognize functional activities which are typically caused by the deployment of improvised explosive devices (IEDs), e.g. excavations, skid marks, footprints, left-behind tooling equipment, and marker stones. Furthermore, in case of natural disasters, like flooding, imminent danger can be recognized quickly. Due to the necessary flight range, we concentrate on fixed wing UAVs. Automatic change detection can be reduced to a comparatively simple photogrammetric problem when the perspective change between the "before" and "after" image sets is kept as small as possible. Therefore, the aerial image acquisition demands a mission planning with a clear purpose including flight path and sensor configuration. While the latter can be enabled simply by a fixed and meaningful adjustment of the camera, ensuring a small perspective change for "before" and "after" videos acquired by fixed wing UAVs is a challenging problem. Concerning this matter, we have performed tests with an advanced commercial off the shelf (COTS) system which comprises a differential GPS and autopilot system estimating the repetition accuracy of its trajectory. Although several similar approaches have been presented,23 as far as we are able to judge, the limits for this important issue are not estimated so far. Furthermore, we design a process chain to enable the practical utilization of video change detection. It consists of a front-end of a database to handle large amounts of video data, an image processing and change detection implementation, and the visualization of the results. We apply our process chain on the real video data acquired by the advanced COTS fixed wing UAV and synthetic data. For the

  12. How wing kinematics affect power requirements and aerodynamic force production in a robotic bat wing

    International Nuclear Information System (INIS)

    Bahlman, Joseph W; Swartz, Sharon M; Breuer, Kenneth S

    2014-01-01

    Bats display a wide variety of behaviors that require different amounts of aerodynamic force. To control and modulate aerodynamic force, bats change wing kinematics, which, in turn, may change the power required for wing motion. There are many kinematic mechanisms that bats, and other flapping animals, can use to increase aerodynamic force, e.g. increasing wingbeat frequency or amplitude. However, we do not know if there is a difference in energetic cost between these different kinematic mechanisms. To assess the relationship between mechanical power input and aerodynamic force output across different isolated kinematic parameters, we programmed a robotic bat wing to flap over a range of kinematic parameters and measured aerodynamic force and mechanical power. We systematically varied five kinematic parameters: wingbeat frequency, wingbeat amplitude, stroke plane angle, downstroke ratio, and wing folding. Kinematic values were based on observed values from free flying Cynopterus brachyotis, the species on which the robot was based. We describe how lift, thrust, and power change with increases in each kinematic variable. We compare the power costs associated with generating additional force through the four kinematic mechanisms controlled at the shoulder, and show that all four mechanisms require approximately the same power to generate a given force. This result suggests that no single parameter offers an energetic advantage over the others. Finally, we show that retracting the wing during upstroke reduces power requirements for flapping and increases net lift production, but decreases net thrust production. These results compare well with studies performed on C. brachyotis, offering insight into natural flight kinematics. (paper)

  13. Morphing Wing Design with an Innovative Three-Dimensional Warping Actuation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced wing configurations where traditional control surfaces are replaced by dynamically controlled distribution of wing twist and/or camber can provide...

  14. Variable Geometry Aircraft Wing Supported by Struts And/Or Trusses

    Science.gov (United States)

    Melton, John E. (Inventor); Dudley, Michael R. (Inventor)

    2016-01-01

    The present invention provides an aircraft having variable airframe geometry for accommodating efficient flight. The aircraft includes an elongated fuselage, an oblique wing pivotally connected with said fuselage, a wing pivoting mechanism connected with said oblique wing and said fuselage, and a brace operably connected between said oblique wing and said fuselage. The present invention also provides an aircraft having an elongated fuselage, an oblique wing pivotally connected with said fuselage, a wing pivoting mechanism connected with said oblique wing and said fuselage, a propulsion system pivotally connected with said oblique wing, and a brace operably connected between said propulsion system and said fuselage.

  15. Numerical simulation of X-wing type biplane flapping wings in 3D using the immersed boundary method

    International Nuclear Information System (INIS)

    Tay, W B; Van Oudheusden, B W; Bijl, H

    2014-01-01

    The numerical simulation of an insect-sized ‘X-wing’ type biplane flapping wing configuration is performed in 3D using an immersed boundary method solver at Reynolds numbers equal to 1000 (1 k) and 5 k, based on the wing's root chord length. This X-wing type flapping configuration draws its inspiration from Delfly, a bio-inspired ornithopter MAV which has two pairs of wings flapping in anti-phase in a biplane configuration. The objective of the present investigation is to assess the aerodynamic performance when the original Delfly flapping wing micro-aerial vehicle (FMAV) is reduced to the size of an insect. Results show that the X-wing configuration gives more than twice the average thrust compared with only flapping the upper pair of wings of the X-wing. However, the X-wing's average thrust is only 40% that of the upper wing flapping at twice the stroke angle. Despite this, the increased stability which results from the smaller lift and moment variation of the X-wing configuration makes it more suited for sharp image capture and recognition. These advantages make the X-wing configuration an attractive alternative design for insect-sized FMAVS compared to the single wing configuration. In the Reynolds number comparison, the vorticity iso-surface plot at a Reynolds number of 5 k revealed smaller, finer vortical structures compared to the simulation at 1 k, due to vortices’ breakup. In comparison, the force output difference is much smaller between Re = 1 k and 5 k. Increasing the body inclination angle generates a uniform leading edge vortex instead of a conical one along the wingspan, giving higher lift. Understanding the force variation as the body inclination angle increases will allow FMAV designers to optimize the thrust and lift ratio for higher efficiency under different operational requirements. Lastly, increasing the spanwise flexibility of the wings increases the thrust slightly but decreases the efficiency. The thrust result is similar

  16. Wing design for light transport aircraft with improved fuel economy

    Energy Technology Data Exchange (ETDEWEB)

    Welte, D.; Birrenbach, R.; Haberland, W.

    An advanced technology wing has been designed for a light utility and commuter service aircraft with the requirements for economy, safety and flexibility. Trade-off studies give optimum area and aspect-ratio of the wing. A new airfoil was developed to fulfill the performance requirements. Wing planform and twist were chosen to give high maximum lift, low drag and good stall characteristics. Preset ailerons were optimized for wheel forces and lateral control. The applied aerodynamic methods, including two- and three-dimensional wind tunnel tests are shown. Various structural configurations of the wing and various flap systems are evaluated. The cantilever tapered wing and a Fowler-flap with a two-lever mechanism were found to be the most economic ones. The wing was constructed and flight-tested with a modified Dornier Do 28 Skyservant as a test bed. The new wing is being applied to a family of light transport aircraft. Finally, aircraft with the new wing are compared performancewise with contemporary aircraft.

  17. Optimisation of the Sekwa blended-wing-Body research UAV

    CSIR Research Space (South Africa)

    Broughton, BA

    2008-10-01

    Full Text Available A variable stability, blended-wing-body research mini-UAV was developed at the CSIR in South Africa. The purpose of the UAV was to study some of the aerodynamic design and control issues associated with flying wing geometries and to develop a...

  18. Flapping-wing mechanical butterfly on a wheel

    Science.gov (United States)

    Godoy-Diana, Ramiro; Thiria, Benjamin; Pradal, Daniel

    2009-11-01

    We examine the propulsive performance of a flapping-wing device turning on a ``merry-go-round'' type base. The two-wing flapper is attached to a mast that is ball-bearing mounted to a central shaft in such a way that the thrust force produced by the wings makes the flapper turn around this shaft. The oscillating lift force produced by the flapping wings is aligned with the mast to avoid vibration of the system. A turning contact allows to power the motor that drives the wings. We measure power consumption and cruising speed as a function of flapping frequency and amplitude as well as wing flexibility. The design of the wings permits to change independently their flexibility in the span-wise and chord-wise directions and PIV measurements in various planes let us examine the vorticity field around the device. A complete study of the effect of wing flexibility on the propulsive performance of the system will be presented at the conference.

  19. Use of wing morphometry for the discrimination of some Cerceris ...

    African Journals Online (AJOL)

    The outline analysis, in which geometric and traditional morphometry potentials are insufficient, was performed by using the Fourier transformation. As a result of the comprehensive wing morphometry study, it was found that both Cerceris species can be distinguished according to their wing structures and the metric ...

  20. Energy-based Aeroelastic Analysis and Optimisation of Morphing Wings

    NARCIS (Netherlands)

    De Breuker, R.

    2011-01-01

    Morphing aircraft can change their shape radically when confronted with a variety of conflicting flight conditions throughout their mission. For instance the F-14 Tomcat fighter aircraft, known from the movie Top Gun, was able to sweep its wings from a straight wing configuration to a highly swept

  1. COLIBRI : A hovering flapping twin-wing robot

    NARCIS (Netherlands)

    Roshanbin, A.; Altartouri, H.; Karasek, M.; Preumont, André

    2017-01-01

    This paper describes the results of a six-year project aiming at designing and constructing a flapping twin-wing robot of the size of hummingbird (Colibri in French) capable of hovering. Our prototype has a total mass of 22 g, a wing span of 21 cm and a flapping frequency of 22 Hz; it is actively

  2. Design, Development and Testing of Shape Shifting Wing Model

    Directory of Open Access Journals (Sweden)

    Dean Ninian

    2017-11-01

    Full Text Available The design and development of morphing (shape shifting aircraft wings—an innovative technology that has the potential to increase the aerodynamic efficiency and reduce noise signatures of aircrafts—was carried out. This research was focused on reducing lift-induced drag at the flaps of the aerofoil and to improve the design to achieve the optimum aerodynamic efficiency. Simulation revealed a 10.8% coefficient of lift increase for the initial morphing wing and 15.4% for the optimized morphing wing as compared to conventional wing design. At angles of attack of 0, 5, 10 and 15 degrees, the optimized wing has an increase in lift-to-drag ratio of 18.3%, 10.5%, 10.6% and 4% respectively when compared with the conventional wing. Simulations also showed that there is a significant improvement on pressure distribution over the lower surface of the morphing wing aerofoil. The increase in flow smoothness and reduction in vortex size reduced pressure drag along the trailing edge of the wing as a result an increase in pressure on the lower surface was experienced. A morphing wing reduced the size of the vortices and therefore the noise levels measured were reduced by up to 50%.

  3. Temporal variation of wing geometry in Aedes albopictus

    Directory of Open Access Journals (Sweden)

    Paloma Oliveira Vidal

    2012-12-01

    Full Text Available Although native to the tropical and subtropical areas of Southeast Asia, Aedes albopictus is now found on five continents, primarily due to its great capacity to adapt to different environments. This species is considered a secondary vector of dengue virus in several countries. Wing geometric morphometrics is widely used to furnish morphological markers for the characterisation and identification of species of medical importance and for the assessment of population dynamics. In this work, we investigated the metric differentiation of the wings of Ae. albopictus samples collected over a four-year period (2007-2010 in São Paulo, Brazil. Wing size significantly decreased during this period for both sexes and the wing shape also changed over time, with the wing shapes of males showing greater differences after 2008 and those of females differing more after 2009. Given that the wings play sex-specific roles, these findings suggest that the males and females could be affected by differential evolutionary pressures. Consistent with this hypothesis, a sexually dimorphic pattern was detected and quantified: the females were larger than the males (with respect to the mean and had a distinct wing shape, regardless of allometric effects. In conclusion, wing alterations, particularly those involving shape, are a sensitive indicator of microevolutionary processes in this species.

  4. Temporal variation of wing geometry in Aedes albopictus.

    Science.gov (United States)

    Vidal, Paloma Oliveira; Carvalho, Eneas; Suesdek, Lincoln

    2012-12-01

    Although native to the tropical and subtropical areas of Southeast Asia, Aedes albopictus is now found on five continents, primarily due to its great capacity to adapt to different environments. This species is considered a secondary vector of dengue virus in several countries. Wing geometric morphometrics is widely used to furnish morphological markers for the characterisation and identification of species of medical importance and for the assessment of population dynamics. In this work, we investigated the metric differentiation of the wings of Ae. albopictus samples collected over a four-year period (2007-2010) in São Paulo, Brazil. Wing size significantly decreased during this period for both sexes and the wing shape also changed over time, with the wing shapes of males showing greater differences after 2008 and those of females differing more after 2009. Given that the wings play sex-specific roles, these findings suggest that the males and females could be affected by differential evolutionary pressures. Consistent with this hypothesis, a sexually dimorphic pattern was detected and quantified: the females were larger than the males (with respect to the mean) and had a distinct wing shape, regardless of allometric effects. In conclusion, wing alterations, particularly those involving shape, are a sensitive indicator of microevolutionary processes in this species.

  5. Hydraulic Evaluation of the Crest Wing Wave Energy Converter

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Antonishen, Michael Patrick

    This report presents the results of an experimental study of the wave energy converting abilities of the Crest Wing wave energy converter (WEC). The Crest Wing is a WEC that uses its movement in matching the shape of an oncoming wave to generate power. Model tests have been performed using a scal...

  6. Unsteady Aerodynamics of Flapping Wing of a Bird

    Directory of Open Access Journals (Sweden)

    M. Agoes Moelyadi

    2013-04-01

    Full Text Available The unsteady flow behavior and time-dependent aerodynamic characteristics of the flapping motion of a bird’s wing were investigated using a computational method. During flapping, aerodynamic interactions between bird wing surfaces and surrounding flow may occur, generating local time-dependent flow changes in the flow field and aerodynamic load of birds. To study the effect of flapping speed on unsteady aerodynamic load, two kinds of computational simulations were carried out, namely a quasi-steady and an unsteady simulation. To mimic the movement of the down-stroke and the upstroke of a bird, the flapping path accorded to a sinus function, with the wing attitude changing in dihedral angle and time. The computations of time-dependent viscous flow were based on the solution of the Reynolds Averaged Navier-Stokes equations by applying the k-e turbulence model. In addition, the discretization for the computational domain around the model used multi-block structured grid to provide more accuracy in capturing viscous flow, especially in the vicinity of the wing and body surfaces, to obtain a proper wing-body geometry model. For this research, the seagull bird was chosen, which has high aspect ratio wings with pointed wing-tips and a high camber wing section. The results include mesh movement, velocity contours as well as aerodynamic coefficients of the flapping motion of the bird at various flapping frequencies.

  7. Vortex coupling in trailing vortex-wing interactions

    Science.gov (United States)

    Chen, C.; Wang, Z.; Gursul, I.

    2018-03-01

    The interaction of trailing vortices of an upstream wing with rigid and flexible downstream wings has been investigated experimentally in a wind tunnel, using particle image velocimetry, hot-wire, force, and deformation measurements. Counter-rotating upstream vortices exhibit increased meandering when they are close to the tip of the downstream wing. The upstream vortex forms a pair with the vortex shed from the downstream wing and then exhibits large displacements around the wing tip. This coupled motion of the pair has been found to cause large lift fluctuations on the downstream wing. The meandering of the vortex pair occurs at the natural meandering frequency of the isolated vortex, with a low Strouhal number, and is not affected by the frequency of the large-amplitude wing oscillations if the downstream wing is flexible. The displacement of the leading vortex is larger than that of the trailing vortex; however, it causes highly correlated variations of the core radius, core vorticity, and circulation of the trailing vortex with the coupled meandering motion. In contrast, co-rotating vortices do not exhibit any increased meandering.

  8. Closed-type wing for drones: positive and negative characteristics

    Directory of Open Access Journals (Sweden)

    Leonid I. Gretchihin

    2014-02-01

    Full Text Available The paper presents the aerodynamics of a wing of a closed oval ellipsoidal shape, designed with the use of the molecular-kinetic theory. The positive and negative characteristics of aircraft - drones with an oval wing are described. The theoretical calculations have been experimentally checked.

  9. DETERMINATION OF COMMERCIAL AIRCRAFT WING GEOMETRY DURING THE FLIGHT

    Directory of Open Access Journals (Sweden)

    V. I. Shevyakov

    2015-01-01

    Full Text Available The article deals with the task of determination of wing shape for sub-sonic commercial aircraft by photogrammetric method. It provides the procedure for measurements taken on ground and in flight. It also provides the outcome of wing twist for commercial aircraft at cruise.

  10. Global Local Structural Optimization of Transportation Aircraft Wings

    NARCIS (Netherlands)

    Ciampa, P.D.; Nagel, B.; Van Tooren, M.J.L.

    2010-01-01

    The study presents a multilevel optimization methodology for the preliminary structural design of transportation aircraft wings. A global level is defined by taking into account the primary wing structural components (i.e., ribs, spars and skin) which are explicitly modeled by shell layered finite

  11. Wing flexibility effects in clap-and-fling

    NARCIS (Netherlands)

    Percin, M.; Hu, Y.; Van Oudheusden, B.W.; Remes, B.; Scarano, F.

    2011-01-01

    The work explores the use of time-resolved tomographic PIV measurements to study a flapping-wing model, the related vortex generation mechanisms and the effect of wing flexibility on the clap-and-fling movement in particular. An experimental setup is designed and realized in a water tank by use of a

  12. 14 CFR 23.302 - Canard or tandem wing configurations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Canard or tandem wing configurations. 23.302 Section 23.302 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Structure General § 23.302 Canard or tandem wing...

  13. Quantitative-genetic analysis of wing form and bilateral asymmetry ...

    Indian Academy of Sciences (India)

    Unknown

    Overall wing size was analysed here using centroid size. (defined as the square root of the sum .... For those isochromosomal lines that were common to both experimental temperatures .... subobscura reared at 18ºC. CS refers to centroid size (values in pixels2; 1 mm = 144 pixels), and WS to wing shape (all values ×. 104).

  14. Mixed ice accretion on aircraft wings

    Science.gov (United States)

    Janjua, Zaid A.; Turnbull, Barbara; Hibberd, Stephen; Choi, Kwing-So

    2018-02-01

    Ice accretion is a problematic natural phenomenon that affects a wide range of engineering applications including power cables, radio masts, and wind turbines. Accretion on aircraft wings occurs when supercooled water droplets freeze instantaneously on impact to form rime ice or runback as water along the wing to form glaze ice. Most models to date have ignored the accretion of mixed ice, which is a combination of rime and glaze. A parameter we term the "freezing fraction" is defined as the fraction of a supercooled droplet that freezes on impact with the top surface of the accretion ice to explore the concept of mixed ice accretion. Additionally we consider different "packing densities" of rime ice, mimicking the different bulk rime densities observed in nature. Ice accretion is considered in four stages: rime, primary mixed, secondary mixed, and glaze ice. Predictions match with existing models and experimental data in the limiting rime and glaze cases. The mixed ice formulation however provides additional insight into the composition of the overall ice structure, which ultimately influences adhesion and ice thickness, and shows that for similar atmospheric parameter ranges, this simple mixed ice description leads to very different accretion rates. A simple one-dimensional energy balance was solved to show how this freezing fraction parameter increases with decrease in atmospheric temperature, with lower freezing fraction promoting glaze ice accretion.

  15. Computation of Lifting Wing-Flap Configurations

    Science.gov (United States)

    Cantwell, Brian; Kwak, Dochan

    1996-01-01

    Research has been carried out on the computation of lifting wing-flap configurations. The long term goal of the research is to develop improved computational tools for the analysis and design of high lift systems. Results show that state-of-the-art computational methods are sufficient to predict time-averaged lift and overall flow field characteristics on simple high-lift configurations. Recently there has been an increased interest in the problem of airframe generated noise and experiments carried out in the 7 x 10 wind tunnel at NASA Ames have identified the flap edge as an important source of noise. A follow-on set of experiments will be conducted toward the end of 1995. The computations being carried out under this project are coordinated with these experiments. In particular, the model geometry being used in the computations is the same as that in the experiments. The geometry consists of a NACA 63-215 Mod B airfoil section which spans the 7 x lO tunnel. The wing is unswept and has an aspect ratio of two. A 30% chord Fowler flap is deployed modifications of the flap edge geometry have been shown to be effective in reducing noise and the existing code is currently being used to compute the effect of a modified geometry on the edge flow.

  16. New aeroelastic studies for a morphing wing

    Directory of Open Access Journals (Sweden)

    Ruxandra Mihaela BOTEZ*

    2012-06-01

    Full Text Available For this study, the upper surface of a rectangular finite aspect ratio wing, with a laminar airfoil cross-section, was made of a carbon-Kevlar composite material flexible skin. This flexible skin was morphed by use of Shape Memory Alloy actuators for 35 test cases characterized by combinations of Mach numbers, Reynolds numbers and angles of attack. The Mach numbers varied from 0.2 to 0.3 and the angles of attack ranged between -1° and 2°. The optimized airfoils were determined by use of the CFD XFoil code. The purpose of this aeroelastic study was to determine the flutter conditions to be avoided during wind tunnel tests. These studies show that aeroelastic instabilities for the morphing configurations considered appeared at Mach number 0.55, which was higher than the wind tunnel Mach number limit speed of 0.3. The wind tunnel tests could thus be performed safely in the 6’×9’ wind tunnel at the Institute for Aerospace Research at the National Research Council Canada (IAR/NRC, where the new aeroelastic studies, applied on morphing wings, were validated.

  17. Towards long term cultivation of Drosophila wing imaginal discs in vitro.

    Science.gov (United States)

    Handke, Björn; Szabad, János; Lidsky, Peter V; Hafen, Ernst; Lehner, Christian F

    2014-01-01

    The wing imaginal disc of Drosophila melanogaster is a prominent experimental system for research on control of cell growth, proliferation and death, as well as on pattern formation and morphogenesis during organogenesis. The precise genetic methodology applicable in this system has facilitated conceptual advances of fundamental importance for developmental biology. Experimental accessibility and versatility would gain further if long term development of wing imaginal discs could be studied also in vitro. For example, culture systems would allow live imaging with maximal temporal and spatial resolution. However, as clearly demonstrated here, standard culture methods result in a rapid cell proliferation arrest within hours of cultivation of dissected wing imaginal discs. Analysis with established markers for cells in S- and M phase, as well as with RGB cell cycle tracker, a novel reporter transgene, revealed that in vitro cultivation interferes with cell cycle progression throughout interphase and not just exclusively during G1. Moreover, quantification of EGFP expression from an inducible transgene revealed rapid adverse effects of disc culture on basic cellular functions beyond cell cycle progression. Disc transplantation experiments confirmed that these detrimental consequences do not reflect fatal damage of imaginal discs during isolation, arguing clearly for a medium insufficiency. Alternative culture media were evaluated, including hemolymph, which surrounds imaginal discs during growth in situ. But isolated larval hemolymph was found to be even less adequate than current culture media, presumably as a result of conversion processes during hemolymph isolation or disc culture. The significance of prominent growth-regulating pathways during disc culture was analyzed, as well as effects of insulin and disc co-culture with larval tissues as potential sources of endocrine factors. Based on our analyses, we developed a culture protocol that prolongs cell

  18. Towards long term cultivation of Drosophila wing imaginal discs in vitro.

    Directory of Open Access Journals (Sweden)

    Björn Handke

    Full Text Available The wing imaginal disc of Drosophila melanogaster is a prominent experimental system for research on control of cell growth, proliferation and death, as well as on pattern formation and morphogenesis during organogenesis. The precise genetic methodology applicable in this system has facilitated conceptual advances of fundamental importance for developmental biology. Experimental accessibility and versatility would gain further if long term development of wing imaginal discs could be studied also in vitro. For example, culture systems would allow live imaging with maximal temporal and spatial resolution. However, as clearly demonstrated here, standard culture methods result in a rapid cell proliferation arrest within hours of cultivation of dissected wing imaginal discs. Analysis with established markers for cells in S- and M phase, as well as with RGB cell cycle tracker, a novel reporter transgene, revealed that in vitro cultivation interferes with cell cycle progression throughout interphase and not just exclusively during G1. Moreover, quantification of EGFP expression from an inducible transgene revealed rapid adverse effects of disc culture on basic cellular functions beyond cell cycle progression. Disc transplantation experiments confirmed that these detrimental consequences do not reflect fatal damage of imaginal discs during isolation, arguing clearly for a medium insufficiency. Alternative culture media were evaluated, including hemolymph, which surrounds imaginal discs during growth in situ. But isolated larval hemolymph was found to be even less adequate than current culture media, presumably as a result of conversion processes during hemolymph isolation or disc culture. The significance of prominent growth-regulating pathways during disc culture was analyzed, as well as effects of insulin and disc co-culture with larval tissues as potential sources of endocrine factors. Based on our analyses, we developed a culture protocol that

  19. Effects of Wing-Cuff on NACA 23015 Aerodynamic Performances

    Directory of Open Access Journals (Sweden)

    Meftah S.M.A

    2014-03-01

    Full Text Available The main subject of this work is the numerical study control of flow separation on a NACA 23015 airfoil by using wing cuff. This last is a leading edge modification done to the wing. The modification consists of a slight extension of the chord on the outboard section of the wings. Different numerical cases are considered for the baseline and modified airfoil NACA 23015 according at different angle of incidence. The turbulence is modeled by two equations k-epsilon model. The results of this numerical investigation showed several benefits of the wing cuff compared with a conventional airfoil and an agreement is observed between the experimental data and the present study. The most intriguing result of this research is the capability for wing cuff to perform short take-offs and landings.

  20. Experimental Investigation of a Wing-in-Ground Effect Craft

    Directory of Open Access Journals (Sweden)

    M. Mobassher Tofa

    2014-01-01

    Full Text Available The aerodynamic characteristics of the wing-in-ground effect (WIG craft model that has a noble configuration of a compound wing was experimentally investigated and Universiti Teknologi Malaysia (UTM wind tunnel with and without endplates. Lift and drag forces, pitching moment coefficients, and the centre of pressure were measured with respect to the ground clearance and the wing angle of attack. The ground effect and the existence of the endplates increase the wing lift-to-drag ratio at low ground clearance. The results of this research work show new proposed design of the WIG craft with compound wing and endplates, which can clearly increase the aerodynamic efficiency without compromising the longitudinal stability. The use of WIG craft is representing an ambitious technology that will help in reducing time, effort, and money of the conventional marine transportation in the future.

  1. Computational wing design studies relating to natural laminar flow

    Science.gov (United States)

    Waggoner, Edgar G.

    1986-01-01

    Two research studies are described which directly relate to the application of natural laminar flow (NLF) technology to transonic transport-type wing planforms. Each involved using state-of-the-art computational methods to design three-dimensional wing contours which generate significant runs of favorable pressure gradients. The first study supported the Variable Sweep Transition Flight Experiment and involves design of a full-span glove which extends from the leading edge to the spoiler hinge line on the upper surface of an F-14 outer wing panel. A wing was designed computationally for a corporate transport aircraft in the second study. The resulting wing design generated favorable pressure gradients from the leading edge aft to the mid-chord on both upper and lower surfaces at the cruise design point. Detailed descriptions of the computational design approach are presented along with the various constraints imposed on each of the designs.

  2. Experimental investigation of a wing-in-ground effect craft.

    Science.gov (United States)

    Tofa, M Mobassher; Maimun, Adi; Ahmed, Yasser M; Jamei, Saeed; Priyanto, Agoes; Rahimuddin

    2014-01-01

    The aerodynamic characteristics of the wing-in-ground effect (WIG) craft model that has a noble configuration of a compound wing was experimentally investigated and Universiti Teknologi Malaysia (UTM) wind tunnel with and without endplates. Lift and drag forces, pitching moment coefficients, and the centre of pressure were measured with respect to the ground clearance and the wing angle of attack. The ground effect and the existence of the endplates increase the wing lift-to-drag ratio at low ground clearance. The results of this research work show new proposed design of the WIG craft with compound wing and endplates, which can clearly increase the aerodynamic efficiency without compromising the longitudinal stability. The use of WIG craft is representing an ambitious technology that will help in reducing time, effort, and money of the conventional marine transportation in the future.

  3. Experimental Investigation of a Wing-in-Ground Effect Craft

    Science.gov (United States)

    Tofa, M. Mobassher; Ahmed, Yasser M.; Jamei, Saeed; Priyanto, Agoes; Rahimuddin

    2014-01-01

    The aerodynamic characteristics of the wing-in-ground effect (WIG) craft model that has a noble configuration of a compound wing was experimentally investigated and Universiti Teknologi Malaysia (UTM) wind tunnel with and without endplates. Lift and drag forces, pitching moment coefficients, and the centre of pressure were measured with respect to the ground clearance and the wing angle of attack. The ground effect and the existence of the endplates increase the wing lift-to-drag ratio at low ground clearance. The results of this research work show new proposed design of the WIG craft with compound wing and endplates, which can clearly increase the aerodynamic efficiency without compromising the longitudinal stability. The use of WIG craft is representing an ambitious technology that will help in reducing time, effort, and money of the conventional marine transportation in the future. PMID:24701170

  4. Relationship between Prior Knowledge and Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Noureldin Mohamed Abdelaal

    2014-12-01

    Full Text Available This study investigates the relationship between prior knowledge and reading comprehension in second language among postgraduate students in UPM. Participants in the study were 20 students who have the same level in English as a second language from several faculties. On the basis of a prior-knowledge questionnaire and test, students were selected; they were asked to sit a two-passage reading comprehension exam. According to the questionnaire and the short prior quiz, students had high prior knowledge in one of the two passages, and low prior knowledge in the other. The result showed significantly high relationship between the high prior knowledge and reading comprehension. However, the results showed significantly low relationship between low prior knowledge and reading comprehension. Yet the performance of students in a reading comprehension with high prior knowledge was significantly better than reading comprehension with low prior knowledge.

  5. Preliminary development of a wing in ground effect vehicle

    Science.gov (United States)

    Abidin, Razali; Ahamat, Mohamad Asmidzam; Ahmad, Tarmizi; Saad, Mohd Rasdan; Hafizi, Ezzat

    2018-02-01

    Wing in ground vehicle is one of the mode of transportation that allows high speed movement over water by travelling few meters above the water level. Through this manouver strategy, a cushion of compressed air exists between the wing in ground vehicle wings and water. This significantly increase the lift force, thus reducing the necessity in having a long wing span. Our project deals with the development of wing in ground vehicle with the capability of transporting four people. The total weight of this wing in ground vehicle was estimated at 5.4 kN to enable the prediction on required wing area, minimum takeoff velocity, drag force and engine power requirement. The required takeoff velocity is decreases as the lift coefficient increases, and our current mathematical model shows the takeoff velocity at 50 m/s avoid the significant increase in lift coefficient for the wing area of 5 m2. At the velocity of 50 m/s, the drag force created by this wing in ground vehicle is well below 1 kN, which required a 100-120 kW of engine power if the propeller has the efficiency of 0.7. Assessment on the stresses and deflection of the hull structural indicate the capability of plywood to withstand the expected load. However, excessive deflection was expected in the rear section which requires a minor structural modification. In the near future, we expect that the wind tunnel tests of this wing in ground vehicle model would enable more definite prediction on the important parameters related to its performance.

  6. Construction and Rescue of a Molecular Clone of Deformed Wing Virus (DWV.

    Directory of Open Access Journals (Sweden)

    Benjamin Lamp

    Full Text Available European honey bees are highly important in crop pollination, increasing the value of global agricultural production by billions of dollars. Current knowledge about virulence and pathogenicity of Deformed wing virus (DWV, a major factor in honey bee colony mortality, is limited. With this study, we close the gap between field research and laboratory investigations by establishing a complete in vitro model for DWV pathogenesis. Infectious DWV was rescued from a molecular clone of a DWV-A genome that induces DWV symptoms such as crippled wings and discoloration. The expression of DWV proteins, production of infectious virus progeny, and DWV host cell tropism could be confirmed using newly generated anti-DWV monoclonal antibodies. The recombinant RNA fulfills Koch's postulates circumventing the need of virus isolation and propagation of pure virus cultures. In conclusion, we describe the development and application of a reverse genetics system for the study of DWV pathogenesis.

  7. Aerodynamic performance of a hovering hawkmoth with flexible wings: a computational approach.

    Science.gov (United States)

    Nakata, Toshiyuki; Liu, Hao

    2012-02-22

    Insect wings are deformable structures that change shape passively and dynamically owing to inertial and aerodynamic forces during flight. It is still unclear how the three-dimensional and passive change of wing kinematics owing to inherent wing flexibility contributes to unsteady aerodynamics and energetics in insect flapping flight. Here, we perform a systematic fluid-structure interaction based analysis on the aerodynamic performance of a hovering hawkmoth, Manduca, with an integrated computational model of a hovering insect with rigid and flexible wings. Aerodynamic performance of flapping wings with passive deformation or prescribed deformation is evaluated in terms of aerodynamic force, power and efficiency. Our results reveal that wing flexibility can increase downwash in wake and hence aerodynamic force: first, a dynamic wing bending is observed, which delays the breakdown of leading edge vortex near the wing tip, responsible for augmenting the aerodynamic force-production; second, a combination of the dynamic change of wing bending and twist favourably modifies the wing kinematics in the distal area, which leads to the aerodynamic force enhancement immediately before stroke reversal. Moreover, an increase in hovering efficiency of the flexible wing is achieved as a result of the wing twist. An extensive study of wing stiffness effect on aerodynamic performance is further conducted through a tuning of Young's modulus and thickness, indicating that insect wing structures may be optimized not only in terms of aerodynamic performance but also dependent on many factors, such as the wing strength, the circulation capability of wing veins and the control of wing movements.

  8. Action priors for learning domain invariances

    CSIR Research Space (South Africa)

    Rosman, Benjamin S

    2015-04-01

    Full Text Available . Aggressive use of action priors performs context based pruning of the available actions, thus reducing the complexity of look ahead during search. We additionally define action priors over observation features, rather than states, which provides further...

  9. Digital Morphing Wing: Active Wing Shaping Concept Using Composite Lattice-Based Cellular Structures.

    Science.gov (United States)

    Jenett, Benjamin; Calisch, Sam; Cellucci, Daniel; Cramer, Nick; Gershenfeld, Neil; Swei, Sean; Cheung, Kenneth C

    2017-03-01

    We describe an approach for the discrete and reversible assembly of tunable and actively deformable structures using modular building block parts for robotic applications. The primary technical challenge addressed by this work is the use of this method to design and fabricate low density, highly compliant robotic structures with spatially tuned stiffness. This approach offers a number of potential advantages over more conventional methods for constructing compliant robots. The discrete assembly reduces manufacturing complexity, as relatively simple parts can be batch-produced and joined to make complex structures. Global mechanical properties can be tuned based on sub-part ordering and geometry, because local stiffness and density can be independently set to a wide range of values and varied spatially. The structure's intrinsic modularity can significantly simplify analysis and simulation. Simple analytical models for the behavior of each building block type can be calibrated with empirical testing and synthesized into a highly accurate and computationally efficient model of the full compliant system. As a case study, we describe a modular and reversibly assembled wing that performs continuous span-wise twist deformation. It exhibits high performance aerodynamic characteristics, is lightweight and simple to fabricate and repair. The wing is constructed from discrete lattice elements, wherein the geometric and mechanical attributes of the building blocks determine the global mechanical properties of the wing. We describe the mechanical design and structural performance of the digital morphing wing, including their relationship to wind tunnel tests that suggest the ability to increase roll efficiency compared to a conventional rigid aileron system. We focus here on describing the approach to design, modeling, and construction as a generalizable approach for robotics that require very lightweight, tunable, and actively deformable structures.

  10. Repeatable Manufacture of Wings for Flapping Wing Micro Air Vehicles Using Microelectromechanical System (MEMS) Fabrication Techniques

    Science.gov (United States)

    2011-03-01

    life span, and must be cared for and used expeditiously. Once a hawkmoth hatches from its cocoon, its wing is liberated, taking care to cut the...more controlled fashion than the butterfly, but is not sufficiently so for a Micro- MAV (courtesy of http://www.science-store.com/ life /specimens/la460...50. Michelson, Robert C. and Naqvi, Messam A. Extraterrestrial Flight. s.l. : RTO- AVT von Karman Institute for Fluid Dynamics Lecture Series, 2003

  11. Control Power Optimization using Artificial Intelligence for Forward Swept Wing and Hybrid Wing Body Aircraft

    OpenAIRE

    Adegbindin, Moustaine Kolawole Agnide

    2017-01-01

    Many futuristic aircraft such as the Hybrid Wing Body have numerous control surfaces that can result in large hinge moments, high actuation power demands, and large actuator forces/moments. Also, there is no unique relationship between control inputs and the aircraft response. Distinct sets of control surface deflections may result in the same aircraft response, but with large differences in actuation power. An Artificial Neural Network and a Genetic Algorithm were used here for the control a...

  12. Iterated random walks with shape prior

    DEFF Research Database (Denmark)

    Pujadas, Esmeralda Ruiz; Kjer, Hans Martin; Piella, Gemma

    2016-01-01

    We propose a new framework for image segmentation using random walks where a distance shape prior is combined with a region term. The shape prior is weighted by a confidence map to reduce the influence of the prior in high gradient areas and the region term is computed with k-means to estimate th...

  13. 34 CFR 642.32 - Prior experience.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Prior experience. 642.32 Section 642.32 Education....32 Prior experience. (a)(1) The Secretary gives priority to each applicant that has conducted a... points to be awarded each eligible applicant, the Secretary considers the applicant's prior experience of...

  14. Prediction of Wing Downwash Using CFD

    Directory of Open Access Journals (Sweden)

    Mohammed MAHDI

    2015-06-01

    Full Text Available Wing downwash study and estimation of downwash effect on the tail plane is an important task during the aircraft design process, although a lot of papers and works has been done, but the experimental work is the most important, the progress in CFD simulation has reached to the point it is able to reduce the number of runs in the wind tunnel. In this work CFD has been utilized to calculate the downwash angle and downwash gradient with respect to the angle of attack over a high aspect ratio of a typical UAV. The results of the simulation shall be used in the estimation and calculation of the longitudinal static stability analysis of the UAV.

  15. Static Aeroelastic Effects of Formation Flight for Slender Unswept Wings

    Science.gov (United States)

    Hanson, Curtis E.

    2009-01-01

    The static aeroelastic equilibrium equations for slender, straight wings are modified to incorporate the effects of aerodynamically-coupled formation flight. A system of equations is developed by applying trim constraints and is solved for component lift distribution, trim angle-of-attack, and trim aileron deflection. The trim values are then used to calculate the elastic twist distribution of the wing box. This system of equations is applied to a formation of two gliders in trimmed flight. Structural and aerodynamic properties are assumed for the gliders, and solutions are calculated for flexible and rigid wings in solo and formation flight. It is shown for a sample application of two gliders in formation flight, that formation disturbances produce greater twist in the wingtip immersed in the vortex than for either the opposing wingtip or the wings of a similar airplane in solo flight. Changes in the lift distribution, resulting from wing twist, increase the performance benefits of formation flight. A flexible wing in formation flight will require greater aileron deflection to achieve roll trim than a rigid wing.

  16. Modeling the Motion of a Flapping Wing Aerial Vehicle

    Directory of Open Access Journals (Sweden)

    Vorochaeva L.Y.

    2017-01-01

    Full Text Available The article discusses the vertical flight of a flapping wing aerial vehicle, which is also called an ornithopter. The robot is a chain of five links connected in series by active cylindrical hinges with the central link being the body and the remainder forming folding wings in pairs. The distinctive feature of this device is that the flaps of its wings imitate those of a seagull i.e. the device has a biological prototype. We construct a mathematical model of this device; much attention is given to the model of the interaction of the wings with the air environment and we determine the positions and velocities of points of application of the reduced aerodynamic forces to each of the links. Based on the results of numerical modelling of the vertical flight of the robot three modes of flight were established: ascent, hovering at a certain height and descent. The device can operate in these modes based on the oscillation parameters of the wings in particular flapping frequency and amplitude, the ratio of the amplitudes of two links and one wing and the shift of the equilibrium oscillation position of the wings relative to zero.

  17. Antibiotics, primary symbionts and wing polyphenism in three aphid species.

    Science.gov (United States)

    Hardie, Jim; Leckstein, Peter

    2007-08-01

    The possible role of the primary Buchnera symbionts in wing polyphenism is examined in three aphid species. Presumptive winged aphids were fed on antibiotic-treated beans to destroy these symbionts. As previously reported, this leads to inhibited growth and low/zero fecundity. When such treatment is applied to the short-day-induced gynoparae (the winged autumn migrant) of the black bean aphid, Aphis fabae, it also causes many insects to develop as wingless or winged/wingless intermediate adult forms (apterisation). However, whilst antibiotic treatment of crowd-induced, long-day winged forms of the pea aphid, Acyrthosiphon pisum (a green and a pink clone) and the vetch aphid, Megoura viciae has similar effects on size and fecundity, it does not affect wing development. Food deprivation also promotes apterisation in A. fabae gynoparae but not in the crowd-induced winged morphs of the other two species. Thus, it appears that apterisation in A. fabae is not a direct effect of antibiotic treatment or a novel role for symbionts but is most likely related to impaired nutrition induced by the loss of the symbiont population.

  18. Computational Optimization of a Natural Laminar Flow Experimental Wing Glove

    Science.gov (United States)

    Hartshom, Fletcher

    2012-01-01

    Computational optimization of a natural laminar flow experimental wing glove that is mounted on a business jet is presented and discussed. The process of designing a laminar flow wing glove starts with creating a two-dimensional optimized airfoil and then lofting it into a three-dimensional wing glove section. The airfoil design process does not consider the three dimensional flow effects such as cross flow due wing sweep as well as engine and body interference. Therefore, once an initial glove geometry is created from the airfoil, the three dimensional wing glove has to be optimized to ensure that the desired extent of laminar flow is maintained over the entire glove. TRANAIR, a non-linear full potential solver with a coupled boundary layer code was used as the main tool in the design and optimization process of the three-dimensional glove shape. The optimization process uses the Class-Shape-Transformation method to perturb the geometry with geometric constraints that allow for a 2-in clearance from the main wing. The three-dimensional glove shape was optimized with the objective of having a spanwise uniform pressure distribution that matches the optimized two-dimensional pressure distribution as closely as possible. Results show that with the appropriate inputs, the optimizer is able to match the two dimensional pressure distributions practically across the entire span of the wing glove. This allows for the experiment to have a much higher probability of having a large extent of natural laminar flow in flight.

  19. Sexual selection on wing interference patterns in Drosophila melanogaster.

    Science.gov (United States)

    Katayama, Natsu; Abbott, Jessica K; Kjærandsen, Jostein; Takahashi, Yuma; Svensson, Erik I

    2014-10-21

    Animals with color vision use color information in intra- and interspecific communication, which in turn may drive the evolution of conspicuous colored body traits via natural and sexual selection. A recent study found that the transparent wings of small flies and wasps in lower-reflectance light environments display vivid and stable structural color patterns, called "wing interference patterns" (WIPs). Such WIPs were hypothesized to function in sexual selection among small insects with wing displays, but this has not been experimentally verified. Here, to our knowledge we present the first experimental evidence that WIPs in males of Drosophila melanogaster are targets of mate choice from females, and that two different color traits--saturation and hue--experience directional and stabilizing sexual selection, respectively. Using isogenic lines from the D. melanogaster Genetic Reference Panel, we compare attractiveness of different male WIPs against black and white visual backgrounds. We show that males with more vivid wings are more attractive to females than are males with dull wings. Wings with a large magenta area (i.e., intermediate trait values) were also preferred over those with a large blue or yellow area. These experimental results add a visual element to the Drosophila mating array, integrating sexual selection with elements of genetics and evo-devo, potentially applicable to a wide array of small insects with hyaline wings. Our results further underscore that the mode of sexual selection on such visual signals can differ profoundly between different color components, in this case hue and saturation.

  20. Flapping and flexible wings for biological and micro air vehicles

    Science.gov (United States)

    Shyy, Wei; Berg, Mats; Ljungqvist, Daniel

    1999-07-01

    Micro air vehicles (MAVs) with wing spans of 15 cm or less, and flight speed of 30-60 kph are of interest for military and civilian applications. There are two prominent features of MAV flight: (i) low Reynolds number (10 4-10 5), resulting in unfavorable aerodynamic conditions to support controlled flight, and (ii) small physical dimensions, resulting in certain favorable scaling characteristics including structural strength, reduced stall speed, and low inertia. Based on observations of biological flight vehicles, it appears that wing motion and flexible airfoils are two key attributes for flight at low Reynolds number. The small size of MAVs corresponds in nature to small birds, which do not glide like large birds, but instead flap with considerable change of wing shape during a single flapping cycle. With flapping and flexible wings, birds overcome the deteriorating aerodynamic performance under steady flow conditions by employing unsteady mechanisms. In this article, we review both biological and aeronautical literatures to present salient features relevant to MAVs. We first summarize scaling laws of biological and micro air vehicles involving wing span, wing loading, vehicle mass, cruising speed, flapping frequency, and power. Next we discuss kinematics of flapping wings and aerodynamic models for analyzing lift, drag and power. Then we present issues related to low Reynolds number flows and airfoil shape selection. Recent work on flexible structures capable of adjusting the airfoil shape in response to freestream variations is also discussed.

  1. Fabrication of corrugated artificial insect wings using laser micromachined molds

    International Nuclear Information System (INIS)

    Tanaka, Hiroto; Wood, Robert J

    2010-01-01

    This paper describes the fabrication of an artificial insect wing with a rich set of topological features by micromolding a thermosetting resin. An example 12 mm long hoverfly-like wing is fabricated with 50–125 µm vein heights and 100 µm corrugation heights. The solid veins and membrane were simultaneously formed and integrated by a single molding process. Employing a layered laser ablation technique, three-dimensional molds were created with 5 µm resolution in height. Safe demolding of the wing was achieved with a water-soluble sacrificial layer on the mold. Measured surface profiles of the wing matched those of the molds, demonstrating the high replication accuracy of this molding process. Using this process, the morphological features of insect wings can be replicated at-scale with high precision, enabling parametric experiments of the functional morphology of insect wings. This fabrication capability also makes it possible to create a variety of wing types for micro air vehicles on scales similar to insects.

  2. The design and testing of subscale smart aircraft wing bolts

    International Nuclear Information System (INIS)

    Vugampore, J M V; Bemont, C

    2012-01-01

    Presently costly periodic inspection is vital in guaranteeing the structural integrity of aircraft. This investigation assesses the potential for significantly reducing aircraft maintenance costs without modification of aircraft structures by implementing smart wing bolts, manufactured from TRIP steel, which can be monitored for damage in situ. TRIP steels undergo a transformation from paramagnetic austenite to ferromagnetic martensite during deformation. Subscale smart aircraft wing bolts were manufactured from hot rolled TRIP steel. These wing bolts were used to demonstrate that washers incorporating embedded inductance coils can be utilized to measure the martensitic transformation occurring in the TRIP steel during bolt deformation. Early in situ warning of a critical bolt stress level was thereby facilitated, potentially reducing the costly requirement for periodic wing bolt removal and inspection. The hot rolled TRIP steels that were utilized in these subscale bolts do not however exhibit the mechanical properties required of wing bolt material. Thus warm rolled TRIP steel alloys were also investigated. The mechanical properties of the best warm rolled TRIP steel alloy tested almost matched those of AISI 4340. The warm rolled alloys were also shown to exhibit transformation before yield, allowing for earlier warning when overload occurs. Further work will be required relating to fatigue crack detection, environmental temperature fluctuation and more thorough material characterization. However, present results show that in situ early detection of wing bolt overload is feasible via the use of high alloy warm rolled TRIP steel wing bolts in combination with inductive sensor embedded washers. (paper)

  3. Free vibration analysis of dragonfly wings using finite element method

    Directory of Open Access Journals (Sweden)

    M Darvizeh

    2016-04-01

    Full Text Available In the present work, investigations on the microstructure and mechanicalproperties of the dragonfly wing are carried out and numerical modelingbased on Finite Element Method (FEM is developed to predict Flightcharacteristics of dragonfly wings. Vibrational behavior of wings typestructures is immensely important in analysis, design and manufacturing ofsimilar engineering structures. For this purpose natural frequencies andmode shapes are calculated. In addition, the kind of deformation in eachmode shape evaluated and the ratio between numerical natural frequencyand experimental natural frequency presented as damping ratio. Theresults obtain from present method are in good agreement with sameexperimental methods.

  4. A Video-Based Experimental Investigation of Wing Rock

    Science.gov (United States)

    1989-08-01

    maintained a negative damping in roll (Fig. 6b). Ross concluded that wing tanks act like an aerodynamic fence, controlling flow separation over the wing...to Ross that wing rock was initiated by a nonlinear yawing moment due to sideslip, which caused a divergent Dutch roll oscillation to grow into the...20 30 40 50 e) (p (D EG) * Fig. 128 Continued S * 158 (Fig. 128a) and cycle B (Fig. 128b ) both occurred early in the 0 build-up and consisted of

  5. Dynamics and control of robotic aircraft with articulated wings

    Science.gov (United States)

    Paranjape, Aditya Avinash

    There is a considerable interest in developing robotic aircraft, inspired by birds, for a variety of missions covering reconnaissance and surveillance. Flapping wing aircraft concepts have been put forth in light of the efficiency of flapping flight at small scales. These aircraft are naturally equipped with the ability to rotate their wings about the root, a form of wing articulation. This thesis covers some problems concerning the performance, stability and control of robotic aircraft with articulated wings in gliding flight. Specifically, we are interested in aircraft without a vertical tail, which would then use wing articulation for longitudinal as well as lateral-directional control. Although the dynamics and control of articulated wing aircraft share several common features with conventional fixed wing aircraft, the presence of wing articulation presents several unique benefits as well as limitations from the perspective of performance and control. One of the objective of this thesis is to understand these features using a combination of theoretical and numerical tools. The aircraft concept envisioned in this thesis uses the wing dihedral angles for longitudinal and lateral-directional control. Aircraft with flexible articulated wings are also investigated. We derive a complete nonlinear model of the flight dynamics incorporating dynamic CG location and the changing moment of inertia. We show that symmetric dihedral configuration, along with a conventional horizontal tail, can be used to control flight speed and flight path angle independently of each other. This characteristic is very useful for initiating an efficient perching maneuver. It is shown that wing dihedral angles alone can effectively regulate sideslip during rapid turns and generate a wide range of equilibrium turn rates while maintaining a constant flight speed and regulating sideslip. We compute the turning performance limitations that arise due to the use of wing dihedral for yaw control

  6. Aeroelastic Tailoring of Transport Wings Including Transonic Flutter Constraints

    Science.gov (United States)

    Stanford, Bret K.; Wieseman, Carol D.; Jutte, Christine V.

    2015-01-01

    Several minimum-mass optimization problems are solved to evaluate the effectiveness of a variety of novel tailoring schemes for subsonic transport wings. Aeroelastic stress and panel buckling constraints are imposed across several trimmed static maneuver loads, in addition to a transonic flutter margin constraint, captured with aerodynamic influence coefficient-based tools. Tailoring with metallic thickness variations, functionally graded materials, balanced or unbalanced composite laminates, curvilinear tow steering, and distributed trailing edge control effectors are all found to provide reductions in structural wing mass with varying degrees of success. The question as to whether this wing mass reduction will offset the increased manufacturing cost is left unresolved for each case.

  7. Winging of scapula due to serratus anterior tear

    Directory of Open Access Journals (Sweden)

    Varun Singh Kumar

    2014-10-01

    Full Text Available 【Abstract】Winging of scapula occurs most commonly due to injury to long thoracic nerve supplying serratus anterior muscle. Traumatic injury to serratus anterior muscle itself is very rare. We reported a case of traumatic winging of scapula due to tear of serratus anterior muscle in a 19-year-old male. Winging was present in neutral position and in extension of right shoulder joint but not on "push on wall" test. Patient was managed conservatively and achieved satisfactory result. Key words: Serratus anterior tear; Scapula; Wounds and injuries

  8. Inwardly rectifying potassium channels influence Drosophila wing morphogenesis by regulating Dpp release.

    Science.gov (United States)

    Dahal, Giri Raj; Pradhan, Sarala Joshi; Bates, Emily Anne

    2017-08-01

    Loss of embryonic ion channel function leads to morphological defects, but the underlying reason for these defects remains elusive. Here, we show that inwardly rectifying potassium (Irk) channels regulate release of the Drosophila bone morphogenetic protein Dpp in the developing fly wing and that this is necessary for developmental signaling. Inhibition of Irk channels decreases the incidence of distinct Dpp-GFP release events above baseline fluorescence while leading to a broader distribution of Dpp-GFP. Work by others in different cell types has shown that Irk channels regulate peptide release by modulating membrane potential and calcium levels. We found calcium transients in the developing wing, and inhibition of Irk channels reduces the duration and amplitude of calcium transients. Depolarization with high extracellular potassium evokes Dpp release. Taken together, our data implicate Irk channels as a requirement for regulated release of Dpp, highlighting the importance of the temporal pattern of Dpp presentation for morphogenesis of the wing. © 2017. Published by The Company of Biologists Ltd.

  9. Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie.

    Science.gov (United States)

    Parker, Joseph; Struhl, Gary

    2015-10-01

    Organ growth is controlled by patterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs], and Hedgehogs [Hhs]) and scaled by nutrient-dependent signals that act systemically (e.g., Insulin-like peptides [ILPs] transduced by the Target of Rapamycin [TOR] pathway). How cells integrate these distinct inputs to generate organs of the appropriate size and shape is largely unknown. The transcriptional coactivator Yorkie (Yki, a YES-Associated Protein, or YAP) acts downstream of patterning morphogens and other tissue-intrinsic signals to promote organ growth. Yki activity is regulated primarily by the Warts/Hippo (Wts/Hpo) tumour suppressor pathway, which impedes nuclear access of Yki by a cytoplasmic tethering mechanism. Here, we show that the TOR pathway regulates Yki by a separate and novel mechanism in the Drosophila wing. Instead of controlling Yki nuclear access, TOR signaling governs Yki action after it reaches the nucleus by allowing it to gain access to its target genes. When TOR activity is inhibited, Yki accumulates in the nucleus but is sequestered from its normal growth-promoting target genes--a phenomenon we term "nuclear seclusion." Hence, we posit that in addition to its well-known role in stimulating cellular metabolism in response to nutrients, TOR also promotes wing growth by liberating Yki from nuclear seclusion, a parallel pathway that we propose contributes to the scaling of wing size with nutrient availability.

  10. Genotoxic evaluation of two oral antidiabetic agents in the Drosophila wing spot test.

    Science.gov (United States)

    Gürbüzel, Mehmet; Çapoğlu, Ilyas; Kızılet, Halit; Halıcı, Zekai; Özçiçek, Fatih; Demirtaş, Levent

    2014-05-01

    In this study, two sulfonylureas--glimepiride and glipizide--commonly used in type 2 diabetes mellitus were investigated for genotoxicity in the Drosophila wing spot test. For this purpose, three-day-old transheterozygous larvae were treated with three mutagenic compounds, and the results obtained were compared with the control group. Mutational or recombinogenic changes were recorded in two recessive genes--multiple wing hairs (mwh) and flare (flr (3)). Two recessive markers were located on the left arm of chromosome 3, mwh in map position 0.3, and flare-3 (flr3) at 38.8, while the centromere was located in position 47.7. Wing spot tests are targeted on the loss of heterozygosity, which may be grounded in different genetic mechanisms such as mutation, mitotic recombination, deletion, half-translocation, chromosome loss, or nondisjunction. Genetic changes formatting in somatic cells of the imaginal discs cause nascence different mutant cloning in different body parts of adult flies. Our in vivo experiments demonstrated that glimepiride and glipizide show the genotoxicity, which is especially dependent on homologous somatic recombination.

  11. Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?

    Science.gov (United States)

    Jiggins, Chris D; Wallbank, Richard W R; Hanly, Joseph J

    2017-02-05

    A major challenge is to understand how conserved gene regulatory networks control the wonderful diversity of form that we see among animals and plants. Butterfly wing patterns are an excellent example of this diversity. Butterfly wings form as imaginal discs in the caterpillar and are constructed by a gene regulatory network, much of which is conserved across the holometabolous insects. Recent work in Heliconius butterflies takes advantage of genomic approaches and offers insights into how the diversification of wing patterns is overlaid onto this conserved network. WntA is a patterning morphogen that alters spatial information in the wing. Optix is a transcription factor that acts later in development to paint specific wing regions red. Both of these loci fit the paradigm of conserved protein-coding loci with diverse regulatory elements and developmental roles that have taken on novel derived functions in patterning wings. These discoveries offer insights into the 'Nymphalid Ground Plan', which offers a unifying hypothesis for pattern formation across nymphalid butterflies. These loci also represent 'hotspots' for morphological change that have been targeted repeatedly during evolution. Both convergent and divergent evolution of a great diversity of patterns is controlled by complex alleles at just a few genes. We suggest that evolutionary change has become focused on one or a few genetic loci for two reasons. First, pre-existing complex cis-regulatory loci that already interact with potentially relevant transcription factors are more likely to acquire novel functions in wing patterning. Second, the shape of wing regulatory networks may constrain evolutionary change to one or a few loci. Overall, genomic approaches that have identified wing patterning loci in these butterflies offer broad insight into how gene regulatory networks evolve to produce diversity.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological

  12. X-38 on B-52 Wing Pylon - View from Observation Window

    Science.gov (United States)

    1997-01-01

    A unique, close-up view of the X-38 under the wing of NASA's B-52 mothership prior to launch of the lifting-body research vehicle. The photo was taken from the observation window of the B-52 bomber as it banked in flight. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In

  13. Manufacturing and Evaluation of a Biologically Inspired Engineered MAV Wing Compared to the Manduca Sexta Wing Under Simulated Flapping Conditions

    Science.gov (United States)

    2011-03-24

    thorax to the wings will continue for a short period of time, preserving the integrity of these wings. This small window was considered in order to...PromasterTM Digital XR EDO Aspherical LD (IF) 17-50 mm 1:2.8 Macro φ 67. Photomodeler provides the means to calibrate a camera via subroutine within...36. 20. DeLeón, N., O’Hara, R., and Palazotto, A., “Manufacturing of Engineering Bio- logically Inspired Flapping Wings,” 25th Annual US- Japan

  14. Ehrlichia chaffeensis infection in the reservoir host (white-tailed deer and in an incidental host (dog is impacted by its prior growth in macrophage and tick cell environments.

    Directory of Open Access Journals (Sweden)

    Arathy D S Nair

    Full Text Available Ehrlichia chaffeensis, transmitted from Amblyomma americanum ticks, causes human monocytic ehrlichiosis. It also infects white-tailed deer, dogs and several other vertebrates. Deer are its reservoir hosts, while humans and dogs are incidental hosts. E. chaffeensis protein expression is influenced by its growth in macrophages and tick cells. We report here infection progression in deer or dogs infected intravenously with macrophage- or tick cell-grown E. chaffeensis or by tick transmission in deer. Deer and dogs developed mild fever and persistent rickettsemia; the infection was detected more frequently in the blood of infected animals with macrophage inoculum compared to tick cell inoculum or tick transmission. Tick cell inoculum and tick transmission caused a drop in tick infection acquisition rates compared to infection rates in ticks fed on deer receiving macrophage inoculum. Independent of deer or dogs, IgG antibody response was higher in animals receiving macrophage inoculum against macrophage-derived Ehrlichia antigens, while it was significantly lower in the same animals against tick cell-derived Ehrlichia antigens. Deer infected with tick cell inoculum and tick transmission caused a higher antibody response to tick cell cultured bacterial antigens compared to the antibody response for macrophage cultured antigens for the same animals. The data demonstrate that the host cell-specific E. chaffeensis protein expression influences rickettsemia in a host and its acquisition by ticks. The data also reveal that tick cell-derived inoculum is similar to tick transmission with reduced rickettsemia, IgG response and tick acquisition of E. chaffeensis.

  15. Deformed wing virus implicated in overwintering honeybee colony losses.

    Science.gov (United States)

    Highfield, Andrea C; El Nagar, Aliya; Mackinder, Luke C M; Noël, Laure M-L J; Hall, Matthew J; Martin, Stephen J; Schroeder, Declan C

    2009-11-01

    The worldwide decline in honeybee colonies during the past 50 years has often been linked to the spread of the parasitic mite Varroa destructor and its interaction with certain honeybee viruses. Recently in the United States, dramatic honeybee losses (colony collapse disorder) have been reported; however, there remains no clear explanation for these colony losses, with parasitic mites, viruses, bacteria, and fungal diseases all being proposed as possible candidates. Common characteristics that most failing colonies share is a lack of overt disease symptoms and the disappearance of workers from what appears to be normally functioning colonies. In this study, we used quantitative PCR to monitor the presence of three honeybee viruses, deformed wing virus (DWV), acute bee paralysis virus (ABPV), and black queen cell virus (BQCV), during a 1-year period in 15 asymptomatic, varroa mite-positive honeybee colonies in Southern England, and 3 asymptomatic colonies confirmed to be varroa mite free. All colonies with varroa mites underwent control treatments to ensure that mite populations remained low throughout the study. Despite this, multiple virus infections were detected, yet a significant correlation was observed only between DWV viral load and overwintering colony losses. The long-held view has been that DWV is relatively harmless to the overall health status of honeybee colonies unless it is in association with severe varroa mite infestations. Our findings suggest that DWV can potentially act independently of varroa mites to bring about colony losses. Therefore, DWV may be a major factor in overwintering colony losses.

  16. Silent and Efficient Supersonic Bi-Directional Flying Wing

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose a Phase I study for a novel concept of a supersonic bi-directional (SBiDir) flying wing (FW) that has the potential to revolutionize supersonic flight...

  17. Application of SMP composite in designing a morphing wing

    Science.gov (United States)

    Yu, Kai; Yin, Weilong; Liu, Yanju; Leng, Jinsong

    2008-11-01

    A new concept of a morphing wing based on shape memory polymer (SMP) and its reinforced composite is proposed in this paper. SMP used in this study is a thermoset styrene-based resin in contrast to normal thermoplastic SMP. In our design, the wing winded on the airframe can be deployed during heating, which provides main lift for a morphing aircraft to realize stable flight. Aerodynamic characteristics of the deployed morphing wing are calculated by using CFD software. The static deformation of the wing under the air loads is also analyzed by using the finite element method. The results show that the used SMP material can provide enough strength and stiffness for the application.

  18. Toward Wing Aerostructural Optimization Using Simultaneous Analysis and Design Strategy

    NARCIS (Netherlands)

    Elham, A.; van Tooren, M.J.L.

    2017-01-01

    The application and computational efficiency of wing aerostructural optimization us- ing simultaneous analysis and design (SAND) strategy is investigated. A coupled adjoint aerostructural analysis method based on quasi-three-dimensional aerodynamic analysis is used for this research. Two different

  19. Pitching stability analysis of half-rotating wing air vehicle

    Science.gov (United States)

    Wang, Xiaoyi; Wu, Yang; Li, Qian; Li, Congmin; Qiu, Zhizhen

    2017-06-01

    Half-Rotating Wing (HRW) is a new power wing which had been developed by our work team using rotating-type flapping instead of oscillating-type flapping. Half-Rotating Wing Air Vehicle (HRWAV) is similar as Bionic Flapping Wing Air Vehicle (BFWAV). It is necessary to guarantee pitching stability of HRWAV to maintain flight stability. The working principle of HRW was firstly introduced in this paper. The rule of motion indicated that the fuselage of HRWAV without empennage would overturn forward as it generated increased pitching movement. Therefore, the empennage was added on the tail of HRWAV to balance the additional moment generated by aerodynamic force during flight. The stability analysis further shows that empennage could weaken rapidly the pitching disturbance on HRWAV and a new balance of fuselage could be achieved in a short time. Case study using numerical analysis verified correctness and validity of research results mentioned above, which could provide theoretical guidance to design and control HRWAV.

  20. Variable camber wing based on pneumatic artificial muscles

    Science.gov (United States)

    Yin, Weilong; Liu, Libo; Chen, Yijin; Leng, Jinsong

    2009-07-01

    As a novel bionic actuator, pneumatic artificial muscle has high power to weight ratio. In this paper, a variable camber wing with the pneumatic artificial muscle is developed. Firstly, the experimental setup to measure the static output force of pneumatic artificial muscle is designed. The relationship between the static output force and the air pressure is investigated. Experimental result shows the static output force of pneumatic artificial muscle decreases nonlinearly with increasing contraction ratio. Secondly, the finite element model of the variable camber wing is developed. Numerical results show that the tip displacement of the trailing-edge increases linearly with increasing external load and limited with the maximum static output force of pneumatic artificial muscles. Finally, the variable camber wing model is manufactured to validate the variable camber concept. Experimental result shows that the wing camber increases with increasing air pressure and that it compare very well with the FEM result.

  1. Comparative Analysis of Uninhibited and Constrained Avian Wing Aerodynamics

    Science.gov (United States)

    Cox, Jordan A.

    The flight of birds has intrigued and motivated man for many years. Bird flight served as the primary inspiration of flying machines developed by Leonardo Da Vinci, Otto Lilienthal, and even the Wright brothers. Avian flight has once again drawn the attention of the scientific community as unmanned aerial vehicles (UAV) are not only becoming more popular, but smaller. Birds are once again influencing the designs of aircraft. Small UAVs operating within flight conditions and low Reynolds numbers common to birds are not yet capable of the high levels of control and agility that birds display with ease. Many researchers believe the potential to improve small UAV performance can be obtained by applying features common to birds such as feathers and flapping flight to small UAVs. Although the effects of feathers on a wing have received some attention, the effects of localized transient feather motion and surface geometry on the flight performance of a wing have been largely overlooked. In this research, the effects of freely moving feathers on a preserved red tailed hawk wing were studied. A series of experiments were conducted to measure the aerodynamic forces on a hawk wing with varying levels of feather movement permitted. Angle of attack and air speed were varied within the natural flight envelope of the hawk. Subsequent identical tests were performed with the feather motion constrained through the use of externally-applied surface treatments. Additional tests involved the study of an absolutely fixed geometry mold-and-cast wing model of the original bird wing. Final tests were also performed after applying surface coatings to the cast wing. High speed videos taken during tests revealed the extent of the feather movement between wing models. Images of the microscopic surface structure of each wing model were analyzed to establish variations in surface geometry between models. Recorded aerodynamic forces were then compared to the known feather motion and surface

  2. Supercritical Wing Technology: A Progress Report on Flight Evaluations

    Science.gov (United States)

    1972-01-01

    The papers in this compilation were presented at the NASA Symposium on "Supercritical Wing Technology: A Progress Report on Flight Evaluation" held at the NASA Flight Research Center, Edwards, Calif., on February 29, 1972. The purpose of the symposium was to present timely information on flight results obtained with the F-8 and T-2C supercritical wing configurations, discuss comparisons with wind-tunnel predictions, and project [ ] flight programs planned for the F-8 and F-III (TACT) airplanes.

  3. Wing sexual dimorphism of pathogen-vector culicids.

    Science.gov (United States)

    Virginio, Flávia; Oliveira Vidal, Paloma; Suesdek, Lincoln

    2015-03-14

    Sexual dimorphism in animals has been studied from different perspectives for decades. In 1874 Darwin hypothesized that it was related to sexual selection, and even after nearly 140 years, when additional empirical data has become available and the subject has been investigated from a contemporary viewpoint, this idea is still supported. Although mosquito (Culicidae) wings are of great importance as they play a sex-specific role, little is known about wing sexual dimorphism in these pathogen-vector insects. Detection and characterization of wing sexual dimorphism in culicids may indirectly enhance our knowledge of their epidemiology or reveal sex-linked genes, aspects that have been discussed by vector control initiatives and developers of genetically modified mosquitoes. Using geometric morphometrics, we carried out a comparative assessment of wing sexual dimorphism in ten culicid species of medical/veterinary importance from genera Culex, Aedes, Anopheles and Ochlerotatus collected in Brazil. Discriminant analysis revealed significant sexual dimorphism in all the species studied, indicating that phenotypic expression of wing shape in mosquitoes is indeed sex-specific. A cross-validated test performed to reclassify the sexes with and without allometry yielded very similar results. Mahalanobis distances among the ten species showed that the species had different patterns of shape sexual dimorphism and that females are larger than males in some species. Wing morphology differed significantly between species. The finding of sexual dimorphism in all the species would suggest that the wing geometry of Culicidae is canalized. Although sexual dimorphism is prevalent, species-specific patterns occur. Allometry was not the main determinant of sexual dimorphism, which suggests that sexual selection or other evolutionary mechanisms underlie wing sexual dimorphism in these insects.

  4. Simulating Bird Strike on Aircraft Composite Wing Leading Edge.

    OpenAIRE

    Ericsson, Max

    2012-01-01

    In this master thesis project the possibility to model the response of a wing when subjected to bird strike using finite elements is analyzed. Since this transient event lasts only a few milliseconds the used solution method is explicit time integration. The wing is manufactured using carbon fiber laminate. Carbon fiber laminates have orthotropic material properties with different stiffness in different directions. Accordingly, there are damage mechanisms not considered when using metal that ...

  5. Shock/shock interactions between bodies and wings

    Directory of Open Access Journals (Sweden)

    Gaoxiang XIANG

    2018-02-01

    Full Text Available This paper examines the Shock/Shock Interactions (SSI between the body and wing of aircraft in supersonic flows. The body is simplified to a flat wedge and the wing is assumed to be a sharp wing. The theoretical spatial dimension reduction method, which transforms the 3D problem into a 2D one, is used to analyze the SSI between the body and wing. The temperature and pressure behind the Mach stem induced by the wing and body are obtained, and the wave configurations in the corner are determined. Numerical validations are conducted by solving the inviscid Euler equations in 3D with a Non-oscillatory and Non-free-parameters Dissipative (NND finite difference scheme. Good agreements between the theoretical and numerical results are obtained. Additionally, the effects of the wedge angle and sweep angle on wave configurations and flow field are considered numerically and theoretically. The influences of wedge angle are significant, whereas the effects of sweep angle on wave configurations are negligible. This paper provides useful information for the design and thermal protection of aircraft in supersonic and hypersonic flows. Keywords: Body and wing, Flow field, Hypersonic flow, Shock/shock interaction, Wave configurations

  6. Unsteady flow over flexible wings at different low Reynolds numbers

    Directory of Open Access Journals (Sweden)

    Genç Mustafa Serdar

    2016-01-01

    Full Text Available In this study, unsteady flow around flexible membrane wing which had aspect ratio of 1 (AR=1 was investigated experimentally at various Reynolds numbers (Re = 25000 and Re = 50000. Smoke-wire technique for flow visualization over the flexible membrane wing was utilized in the experiments. Digital Image Correlation system (DIC was used for measuring deformation of AR = 1 flexible membrane wing. Instantaneous deformation measurements of membrane wing were combined with the flow field measurements. In low aspect ratio flexible membrane wings, unsteadiness includes tip vortices and vortex shedding, and the combination of tip vortices. In these types of wings, complex unsteady deformations occurred due to vortex shedding. The results showed that the increasing angle of attack results in increase of membrane deformation. Moreover, it was concluded that analysis of the instantaneous deformation revealed chordwise and spanwise, modes which were due to the shedding of leading-edge vortices as well as tip vortices. Consequently, vibrational mode decreased and maximum standard deviation location approached to the trailing edge by reason of increasing angle of attack.

  7. Effect of flexibility on flapping wing characteristics under forward flight

    International Nuclear Information System (INIS)

    Zhu, Jianyang; Jiang, Lin; Zhou, Chaoying; Wang, Chao

    2014-01-01

    Through two-dimensional numerical simulation and by solving the unsteady incompressible Navier–Stokes (NS) equations, coupled with the structural dynamic equation for the motion of the wing, the effect of flexibility on flapping wing characteristics during forward flight is systematically studied. The flapping wing is considered as a cantilever, which performs the translational and rotational motion at its leading edge, and the other part is passively deformed by the aerodynamic force. The frequency ratio ω* and mass ratio m* are defined and used to characterize the flexibility of the flapping wing. It has been found that an optimal range of the frequency ratio exists in which the flexible wing possesses both a larger propulsive efficiency and lifting efficiency than their rigid counterpart. Also, the flexible wing with the smaller mass ratio may be of benefit to generate thrust, while the larger mass ratio may be of benefit to generate lift. In addition, a stronger leading edge vortex and reattachment vortex are observed around the appropriate flexibility wing’s surface, which therefore leads to better aerodynamic characteristics. (paper)

  8. Application of Piezoelectrics to Flapping-Wing MAVs

    Science.gov (United States)

    Widstrand, Alex; Hubner, J. Paul

    2015-11-01

    Micro air vehicles (MAVs) are a class of unmanned aerial vehicles that are size-restricted and operate at low velocities and low Reynolds numbers. An ongoing challenge with MAVs is that their flight-related operations are highly constrained by their size and weight, which limits battery size and, therefore, available power. One type of MAV called an ornithopter flies using flapping wings to create both lift and thrust, much like birds and insects do. Further bio-inspiration from bats led to the design of membrane wings for these vehicles, which provide aerodynamic benefits through passive vibration. In an attempt to capitalize on this vibration, a piezoelectric film, which generates a voltage when stressed, was investigated as the wing surface. Two wing planforms with constant area were designed and fabricated. The goal was to measure the wings' flight characteristics and output energy in freestream conditions. Complications with the flapper arose which prevented wind tunnel tests from being performed; however, energy data was obtained from table-top shaker tests. Preliminary results indicate that wing shape affects the magnitude of the charge generated, with a quarter-elliptic planform outperforming a rectangular planform. Funding provided by NSF REU Site Award number 1358991.

  9. Flow structure on a rotating wing undergoing deceleration to rest

    Science.gov (United States)

    Tudball Smith, Daniel; Rockwell, Donald; Sheridan, John

    2013-11-01

    Inspired by the behavior of small biological flyers and micro aerial Vehicles, this study experimentally addresses the flow structure on a low aspect ratio rotating wing at low Reynolds number. The study focuses on a wing decelerating to rest after rotating at constant velocity. The wing was set to a constant 45° angle of attack and, during the initial phase of the motion, accelerated to a constant velocity at its radius of gyration, which resulted in a Reynolds number of 1400 based on the chord length. Stereoscopic PIV was used to construct phase-averaged three-dimensional (volumetric) velocity fields that develop and relax throughout the deceleration and cessation of the wing motion. During gradual deceleration, the flow structure is maintained when normalised by the instantaneous velocity; the distinguishing feature is shedding of a trailing edge vortex that develops due to the deceleration. At higher deceleration rates to rest, the flow structure quickly degrades. Induced flow in the upstream direction along the surface of the wing causes detachment of the previously stable leading edge vortex; simultaneously, a trailing-edge vortex and the reoriented tip vortex form a co-rotating vortex pair, drawing flow downward away from the wing.

  10. Structure design of an innovative adaptive variable camber wing

    Directory of Open Access Journals (Sweden)

    Zhao An-Min

    2018-01-01

    Full Text Available In this paper, an innovative double rib sheet structure is proposed, which can replace the traditional rigid hinge joint with the surface contact. On the one hand, the variable camber wing structural design not only can improve the capacity to sustain more load but also will not increase the overall weight of the wing. On the other hand, it is a simple mechanical structure design to achieve the total wing camber change. Then the numerical simulation results show that the maximum stress at the connect of the wing rib is 88.2MPa, and the double ribs sheet engineering design meet the structural strength requirements. In addition, to make a fair comparison, the parameters of variable camber are fully referenced to the Talon Unmanned Aerial Vehicle (UAV. The results reveal that the total variable camber wing can further enhance aircraft flight efficiency by 29.4%. The design of the whole variable camber wing structure proposed in this paper has high engineering value and feasibility.

  11. Flying Wings. A New Paradigm for Civil Aviation?

    Directory of Open Access Journals (Sweden)

    R. Martinez-Val

    2007-01-01

    Full Text Available Over the last 50 years, commercial aviation has been mainly based what is currently called the conventional layout, characterized by a slender fuselage mated to a high aspect ratio wing, with aft-tail planes and pod-mounted engines under the wing. However, it seems that this primary configuration is approaching an asymptote in its productivity and performance characteristics. One of the most promising configurations for the future is the flying wing in its distinct arrangements: blended-wing-body, C-wing, tail-less aircraft, etc. These layouts might provide significant fuel savings and, hence, a decrease in pollution. This configuration would also reduce noise in take-off and landing. All this explains the great deal of activity carried out by the aircraft industry and by numerous investigators to perform feasibility and conceptual design studies of this aircraft layout to gain better knowledge of its main characteristics: productivity, airport compatibility, passenger acceptance, internal architecture, emergency evacuation, etc. The present paper discusses the main features of flying wings, their advantages over conventional competitors, and some key operational issues, such as evacuation and vortex wake intensity. 

  12. Wing-pitching mechanism of hovering Ruby-throated hummingbirds.

    Science.gov (United States)

    Song, Jialei; Luo, Haoxiang; Hedrick, Tyson L

    2015-01-19

    In hovering flight, hummingbirds reverse the angle of attack of their wings through pitch reversal in order to generate aerodynamic lift during both downstroke and upstroke. In addition, the wings may pitch during translation to further enhance lift production. It is not yet clear whether these pitching motions are caused by the wing inertia or actuated through the musculoskeletal system. Here we perform a computational analysis of the pitching dynamics by incorporating the realistic wing kinematics to determine the inertial effects. The aerodynamic effect is also included using the pressure data from a previous three-dimensional computational fluid dynamics simulation of a hovering hummingbird. The results show that like many insects, pitch reversal of the hummingbird is, to a large degree, caused by the wing inertia. However, actuation power input at the root is needed in the beginning of pronation to initiate a fast pitch reversal and also in mid-downstroke to enable a nose-up pitching motion for lift enhancement. The muscles on the wing may not necessarily be activated for pitching of the distal section. Finally, power analysis of the flapping motion shows that there is no requirement for substantial elastic energy storage or energy absorption at the shoulder joint.

  13. Wing-pitching mechanism of hovering Ruby-throated hummingbirds

    International Nuclear Information System (INIS)

    Song, Jialei; Luo, Haoxiang; Hedrick, Tyson L

    2015-01-01

    In hovering flight, hummingbirds reverse the angle of attack of their wings through pitch reversal in order to generate aerodynamic lift during both downstroke and upstroke. In addition, the wings may pitch during translation to further enhance lift production. It is not yet clear whether these pitching motions are caused by the wing inertia or actuated through the musculoskeletal system. Here we perform a computational analysis of the pitching dynamics by incorporating the realistic wing kinematics to determine the inertial effects. The aerodynamic effect is also included using the pressure data from a previous three-dimensional computational fluid dynamics simulation of a hovering hummingbird. The results show that like many insects, pitch reversal of the hummingbird is, to a large degree, caused by the wing inertia. However, actuation power input at the root is needed in the beginning of pronation to initiate a fast pitch reversal and also in mid-downstroke to enable a nose-up pitching motion for lift enhancement. The muscles on the wing may not necessarily be activated for pitching of the distal section. Finally, power analysis of the flapping motion shows that there is no requirement for substantial elastic energy storage or energy absorption at the shoulder joint. (paper)

  14. Reassessment of the wing feathers of Archaeopteryx lithographica suggests no robust evidence for the presence of elongated dorsal wing coverts.

    Directory of Open Access Journals (Sweden)

    Robert L Nudds

    Full Text Available Recently it was proposed that the primary feathers of Archaeopteryx lithographica (HMN1880 were overlaid by long covert feathers, and that a multilayered feathered wing was a feature of early fossils with feathered forelimbs. The proposed long covert feathers of Archaeopteryx were previously interpreted as dorsally displaced remiges or a second set of impressions made by the wing. The following study shows that the qualitative arguments forwarded in support of the elongated covert hypothesis are neither robust nor supported quantitatively. The idea that the extant bird wing with its single layer of overlapping primaries evolved from an earlier multilayered heavily coveted feathered forelimb as seen in Anchiornis huxleyi is reasonable. At this juncture, however, it is premature to conclude unequivocally that the wing of Archaeopteryx consisted of primary feathers overlaid with elongated coverts.

  15. Penalised Complexity Priors for Stationary Autoregressive Processes

    KAUST Repository

    Sørbye, Sigrunn Holbek

    2017-05-25

    The autoregressive (AR) process of order p(AR(p)) is a central model in time series analysis. A Bayesian approach requires the user to define a prior distribution for the coefficients of the AR(p) model. Although it is easy to write down some prior, it is not at all obvious how to understand and interpret the prior distribution, to ensure that it behaves according to the users\\' prior knowledge. In this article, we approach this problem using the recently developed ideas of penalised complexity (PC) priors. These prior have important properties like robustness and invariance to reparameterisations, as well as a clear interpretation. A PC prior is computed based on specific principles, where model component complexity is penalised in terms of deviation from simple base model formulations. In the AR(1) case, we discuss two natural base model choices, corresponding to either independence in time or no change in time. The latter case is illustrated in a survival model with possible time-dependent frailty. For higher-order processes, we propose a sequential approach, where the base model for AR(p) is the corresponding AR(p-1) model expressed using the partial autocorrelations. The properties of the new prior distribution are compared with the reference prior in a simulation study.

  16. Fuzzy Model-based Pitch Stabilization and Wing Vibration Suppression of Flexible Wing Aircraft.

    Science.gov (United States)

    Ayoubi, Mohammad A.; Swei, Sean Shan-Min; Nguyen, Nhan T.

    2014-01-01

    This paper presents a fuzzy nonlinear controller to regulate the longitudinal dynamics of an aircraft and suppress the bending and torsional vibrations of its flexible wings. The fuzzy controller utilizes full-state feedback with input constraint. First, the Takagi-Sugeno fuzzy linear model is developed which approximates the coupled aeroelastic aircraft model. Then, based on the fuzzy linear model, a fuzzy controller is developed to utilize a full-state feedback and stabilize the system while it satisfies the control input constraint. Linear matrix inequality (LMI) techniques are employed to solve the fuzzy control problem. Finally, the performance of the proposed controller is demonstrated on the NASA Generic Transport Model (GTM).

  17. The Effect of Height, Wing Length, and Wing Symmetry on Tabebuia rosea Seed Dispersal

    Directory of Open Access Journals (Sweden)

    Yasmeen Moussa

    2014-12-01

    Full Text Available The relationship between the vertical drop height and the horizontal distance traveled (dispersal ratio was investigated for a sample of fifty Tabebuia rosea seeds by dropping the seeds from five heights ranging from 1.00 to 2.00 meters. The dispersal ratio was found to be a constant 0.16 m/m for these heights. The effects of total seed length and asymmetry of seed wings on dispersal ratio were also measured using separate samples of fifty Tabebuia rosea seeds. It was found that neither seed length nor asymmetry had a significant effect on the dispersal ratio.

  18. Aerodynamic effects of corrugation and deformation in flapping wings of hovering hoverflies.

    Science.gov (United States)

    Du, Gang; Sun, Mao

    2012-05-07

    We investigated the aerodynamic effects of wing deformation and corrugation of a three-dimensional model hoverfly wing at a hovering condition by solving the Navier-Stokes equations on a dynamically deforming grid. Various corrugated wing models were tested. Insight into whether or not there existed significant aerodynamic coupling between wing deformation (camber and twist) and wing corrugation was obtained by comparing aerodynamic forces of four cases: a smooth-plate wing in flapping motion without deformation (i.e. a rigid flat-plate wing in flapping motion); a smooth-plate wing in flapping motion with deformation; a corrugated wing in flapping motion without deformation (i.e. a rigid corrugated wing in flapping motion); a corrugated wing in flapping motion with deformation. There was little aerodynamic coupling between wing deformation and corrugation: the aerodynamic effect of wing deformation and corrugation acting together was approximately a superposition of those of deformation and corrugation acting separately. When acting alone, the effect of wing deformation was to increase the lift by 9.7% and decrease the torque (or aerodynamic power) by 5.2%, and that of wing corrugation was to decrease the lift by 6.5% and increase the torque by 2.2%. But when acting together, the wing deformation and corrugation only increased the lift by ~3% and decreased the torque by ~3%. That is, the combined aerodynamic effect of deformation and corrugation is rather small. Thus, wing corrugation is mainly for structural, not aerodynamic, purpose, and in computing or measuring the aerodynamic forces, using a rigid flat-plate wing to model the corrugated deforming wing at hovering condition can be a good approximation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. The morphology of mouthparts, wings and genitalia of Paleozoic insect families Protohymenidae and Scytohymenidae reveals new details and supposed function.

    Science.gov (United States)

    Pecharová, Martina; Prokop, Jakub

    2018-01-01

    Megasecoptera is an extinct group of insects with specialized rostrum-like mouthparts, which is a synapomorphy shared with all members of the Late Paleozoic Palaeodictyopterida, and markedly slender wings that are unable to flex backwards. Here we describe the close up morphology of Protohymenidae and Scytohymenidae and uncover new aspects of the endoskeleton (tentorium) of the head, structure of the mouthparts with discernible proximal part of stylets controlled by muscles, surface of compound eyes that consist of a hexagonal pattern of large facets, structure and microstructures on the wings and reconstruct male and female external genitalia using ESEM and light stereomicroscopy. Furthermore, we describe Protohymen novokshonovi sp. n. based on an exceptionally well preserved fossil from the early Permian at Tshekarda in Russia, which shows crucial details, and the earliest species of Protohymenidae, Carbohymen testai gen. et sp. n. from a late Carboniferous siderite nodule at Mazon Creek in Illinois, USA. Our comparative study confirmed a set of structural and microstructural details on their wings, such as the composite anterior wing margin, development of an apical cell and the previously unknown external genitalia. Based on the results and comparison of homologous structures known primarily for extant relatives, such as mayflies and dragonflies, we outline for the first time the function of the mouthparts, in particular, the stylets, structure of the tentorium, vision provided by large hexagonal ommatidia and male copulatory structures bearing curved claspers for holding a female during copulation and penial lobes with seminal grooves. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Butterfly wing colors : glass scales of Graphium sarpedon cause polarized iridescence and enhance blue/green pigment coloration of the wing membrane

    NARCIS (Netherlands)

    Stavenga, Doekele G.; Giraldo, Marco A.; Leertouwer, Hein L.

    2010-01-01

    The wings of the swordtail butterfly Graphium sarpedon nipponum contain the bile pigment sarpedobilin, which causes blue/green colored wing patches. Locally the bile pigment is combined with the strongly blue-absorbing carotenoid lutein, resulting in green wing patches and thus improving camouflage.

  1. Observations and Measurements of Wing Parameters of the Selected Beetle Species and the Design of a Mechanism Structure Implementing a Complex Wing Movement

    Science.gov (United States)

    Geisler, T.

    2016-12-01

    Beetle wings perform a flapping movement, consisting of the rotation relative to the two axes. This paper presents the results of observations and measurements of wings operating parameters in different planes of some beetle species. High speed photos and videos were used. The concept of the mechanism performing a complex wing movement was proposed and developed.

  2. Observations and Measurements of Wing Parameters of the Selected Beetle Species and the Design of a Mechanism Structure Implementing a Complex Wing Movement

    Directory of Open Access Journals (Sweden)

    Geisler T.

    2016-12-01

    Full Text Available Beetle wings perform a flapping movement, consisting of the rotation relative to the two axes. This paper presents the results of observations and measurements of wings operating parameters in different planes of some beetle species. High speed photos and videos were used. The concept of the mechanism performing a complex wing movement was proposed and developed.

  3. Induced mutations of winged bean in Ghana

    International Nuclear Information System (INIS)

    Klu, G.Y.P.; Quaynor-Addy, M.; Dinku, E.; Dikumwin, E.

    1989-01-01

    Winged bean (Psophocarpus tetragonolobus (L.) D.C.) was introduced into Ghana about two decades ago and not long after a high quality baby food was compounded from it. Germplasm collections are established at the Kade Agricultural Research Station of the University of Ghana and the University of Cape Coast. In 1980 a mutation breeding project was initiated at the University of Cape Coast under FAO/IAEA research contract and among various mutants a single erect stem mutant, a multiple branched bush type and a mutant with extra long pods were obtained. A similar programme was started at the National Nuclear Research Centre Kwabenya in 1982. Seeds of accessions UPS 122 and Kade 6/16 were gamma irradiated (100-400 Gy). In M 2 a mutant was obtained that did not flower throughout a growing period of five months. This mutant had very few leaves but developed an underground tuber weighing ca. 100 g. The parent, UPS 122, although normally tuber producing did not form tubers at Kwabenya within the period studied. In M 3 , mutants with variations in seed size and seed coat colour have been detected

  4. A new technique for investigating the induced and profile drag coefficients of a smooth wing and a tubercled wing

    Directory of Open Access Journals (Sweden)

    Bolzon Michael

    2016-01-01

    Full Text Available The induced and profile drag coefficients of a wing are typically determined through a complex experimental technique, such as wake surveying. Such a technique requires measurement of all three orthogonal components of the downstream velocity to find the components of drag, which results in the necessary usage of a sophisticated and costly measurement device, such as multi-hole pressure probe. However, in this paper data is presented which demonstrate that the relative changes in the induced and profile drag coefficients can largely be determined through the sole measurement of the downstream, streamwise velocity. To demonstrate this, the induced and profile drags of two NACA 0021 wings, one with a smooth leading edge and the other wing a tubercled leading edge for comparison, are determined through the measurement of the three orthogonal velocities. The downstream, streamwise velocity distribution of each wing is then constructed and relationships can be determined. The wings were surveyed at 3°, 9°, and 12°. It has been found that the relative magnitude of the profile drag coefficient can be found for all considered angles of attack, while the relative magnitude of the induced drag coefficient can be found at 9° and 12°. These findings produce an innovative, simpler, and more cost effective experimental technique in determining the components of drag of a wing, and reduces the burdensome requirement of a sophisticated measurement device for such an experiment. Further investigation is required to determine the induced drag at 3°.

  5. Assessing genotoxicity of diuron on Drosophila melanogaster by the wing-spot test and the wing imaginal disk comet assay.

    Science.gov (United States)

    Peraza-Vega, Ricardo I; Castañeda-Sortibrán, América N; Valverde, Mahara; Rojas, Emilio; Rodríguez-Arnaiz, Rosario

    2017-05-01

    The aim of this study was to evaluate the genotoxicity of the herbicide diuron in the wing-spot test and a novel wing imaginal disk comet assay in Drosophila melanogaster. The wing-spot test was performed with standard (ST) and high-bioactivation (HB) crosses after providing chronic 48 h treatment to third instar larvae. A positive dose-response effect was observed in both crosses, but statistically reduced spot frequencies were registered for the HB cross compared with the ST. This latter finding suggests that metabolism differences play an important role in the genotoxic effect of diuron. To verify diuron's ability to produce DNA damage, a wing imaginal disk comet assay was performed after providing 24 h diuron treatment to ST and HB third instar larvae. DNA damage induced by the herbicide had a significantly positive dose-response effect even at very low concentrations in both strains. However, as noted for the wing-spot test, a significant difference between strains was not observed that could be related to the duration of exposure between both assays. A positive correlation between the comet assay and the wing-spot test was found with regard to diuron genotoxicity.

  6. MicroRNAs of the mesothorax in Qinlingacris elaeodes, an alpine grasshopper showing a wing polymorphism with unilateral wing form.

    Science.gov (United States)

    Li, R; Jiang, G F; Ren, Q P; Wang, Y T; Zhou, X M; Zhou, C F; Qin, D Z

    2016-04-01

    MicroRNAs (miRNAs) are now recognized as key post-transcriptional regulators in regulation of phenotypic diversity. Qinlingacris elaeodes is a species of the alpine grasshopper, which is endemic to China. Adult individuals have three wing forms: wingless, unilateral-winged and short-winged. This is an ideal species to investigate the phenotypic plasticity, development and evolution of insect wings because of its case of unilateral wing form in both the sexes. We sequenced a small RNA library prepared from mesothoraxes of the adult grasshoppers using the Illumina deep sequencing technology. Approximately 12,792,458 raw reads were generated, of which the 854,580 high-quality reads were used only for miRNA identification. In this study, we identified 49 conserved miRNAs belonging to 41 families and 69 species-specific miRNAs. Moreover, seven miRNA*s were detected both for conserved miRNAs and species-specific miRNAs, which were supported by hairpin forming precursors based on polymerase chain reaction. This is the first description of miRNAs in alpine grasshoppers. The results provide a useful resource for further studies on molecular regulation and evolution of miRNAs in grasshoppers. These findings not only enrich the miRNAs for insects but also lay the groundwork for the study of post-transcriptional regulation of wing forms.

  7. Physiological trade-off between cellular immunity and flight capability in the wing-dimorphic cricket, Gryllus firmus

    Science.gov (United States)

    The sand cricket, Gryllus firmus, is a wing-dimorphic species with long-wing (LW) and short wing (LW) morphs. The LW forms have very well developed wings and flight muscles and their SW counterparts have reduced wings and flight muscles, coupled with greater resource allocations to reproduction. Thi...

  8. winged eye Induces Transdetermination of Drosophila Imaginal Disc by Acting in Concert with a Histone Methyltransferase, Su(var3-9

    Directory of Open Access Journals (Sweden)

    Keita Masuko

    2018-01-01

    Full Text Available Summary: Drosophila imaginal disc cells exhibit a remarkable ability to convert cell fates in response to various perturbations, a phenomenon called transdetermination (TD. We previously identified winged eye (wge as a factor that induces eye-to-wing TD upon overexpression in eye imaginal discs, but the molecular mechanisms underlying TD have remained largely unclear. Here, we found that wge induces various histone modifications and enhances the methylation of Lys9 on histone H3 (H3K9, a feature of heterochromatin. A histone methyltransferase, Su(var3-9, is required for wge-mediated H3K9 methylation and eye-to-wing TD. Su(var3-9 is also required for classical wound-induced TD but not for normal development, suggesting its involvement in several types of imaginal disc TDs. Transcriptome analysis revealed that wge represses eye identity genes independently of Su(var3-9 and activates TD-related genes by acting together with Su(var3-9. These findings provide new insights into diverse types of chromatin regulation at progressive steps of cell-fate conversions. : Drosophila imaginal discs switch disc identity by a process known as transdetermination. Masuko et al. demonstrate that expression of the winged eye gene induces transdetermination through histone modifications such as H3K9-methylation. winged eye regulates expression of transdetermination-related genes via a histone methyltransferase, Su(var3-9. Keywords: Drosophila, imaginal disc, transdetermination, heterochromatin, cell fate, winged eye, reprogramming, Su(var3-9

  9. Pulsed eddy current inspection of CF-188 inner wing spar

    Science.gov (United States)

    Horan, Peter Francis

    Royal Canadian Air Force (RCAF) CF-188 Hornet aircraft engineering authorities have stated a requirement for a Non-Destructive Evaluation (NDE) technique to detect Stress Corrosion Cracking (SCC) in the inner wing spars without fastener or composite wing skin removal. Current radiographic inspections involve significant aircraft downtime, and Pulsed Eddy Current (PEC) inspection is proposed as a solution. The aluminum inner wing spars of CF-188 Hornet aircraft may undergo stress corrosion cracking (SCC) along the spar between the fasteners that secure carbon-fiber/ epoxy composite skin to the wing. Inspection of the spar through the wing skin is required to avoid wing disassembly. The thickness of the wing skin varies between 8 and 20 mm (0.3 to 0.8 inch) and fasteners may be either titanium or ferrous. PEC generated by a probe centered over a fastener, demonstrates capability of detecting simulated cracks within spars with the wing skin present. Comparison of signals from separate sensors, mounted to either side of the excitation coil, is used to detect differences in induced eddy current fields, which arise in the presence of cracks. To overcome variability in PEC signal response due to variation in 1) skin thickness, 2) fastener material and size, and 3) centering over fasteners, a large calibration data set is acquired. Multi-dimensional scores from a Modified Principal Components Analysis (PCA) of the data are reduced to one dimension (1D) using a Discriminant Analysis method. Under inspection conditions, calibrated PCA scores combined with discriminant analysis permit rapid real time go/no-go PEC detection of cracks in CF-188 inner wing spar. Probe designs using both pickup coils and Giant Magnetoresistive (GMR) sensors were tested on samples with the same ferrous and titanium fasteners found on the CF-188. Flaws were correctly detected at lift-offs of up to 21mm utilizing a variety of insulating skin materials simulating the carbon-fibre reinforced polymer

  10. Investigation of asymmetry of vortex flow over slender delta wings

    Science.gov (United States)

    Atashbaz, Ghasem

    Vortex flow, a major area of interest in fluid mechanics, is widespread in nature and in many man-made fluid mechanical devices. It can create havoc as cyclones or tornadoes or have significant implications in the performance of turbo-fluid machines or supersonic vehicles and so forth. Asymmetric vortices can cause a loss of lift and increase in rolling moment which can significantly affect wing stability and control. Up until the early nineties, it was generally believed that vortex asymmetry was the result of vortex interactions due to the close proximity of vortices over slender delta wings. However, some recent studies have thrown considerable doubt on the validity of this hypothesis. As a result, wind tunnel investigations were conducted on a series of nine delta wing planforms with sharp and round leading edges to examine the occurrence of vortex asymmetry at different angles of attack and sideslip. The study included surface oil and laser light sheet flow visualization in addition to surface pressure and hot-wire velocity measurements under static conditions. The effects of incidence, sideslip and sweep angles as well as Reynolds number variations were investigated. In this study, it was found that the effect of apex and leading edge shape played an important role in vortex asymmetry generation at high angle of attack. Vortex asymmetry was not observed over slender sharp leading edge delta wings due to the separation point being fixed at the sharp leading edge. Experimental results for these wings showed that the vortices do not impinge on one another because they do not get any closer beyond a certain value of angle of attack. Thus vortex asymmetry was not generated. However, significant vortex asymmetry was observed for round leading-edged delta wings. Asymmetric separation positions over the round leading edge was the result of laminar/turbulent transition which caused vortex asymmetry on these delta wing configurations. Sideslip angle and vortex

  11. Suprarenal inferior vena cava filter placement prior to transcatheter arterial embolization (TAE) of a renal cell carcinoma with large renal vein tumor thrombus: Prevention of pulmonary tumor emboli after TAE

    International Nuclear Information System (INIS)

    Hirota, Shozo; Matsumoto, Shinnichi; Ichikawa, Satoshi; Tomita, Masaru; Koshino, Tukasa; Sako, Masao; Kono, Michio

    1997-01-01

    To prevent embolization of necrotic renal vein tumor after transcatheter embolization of a left renal cell carcinoma, we placed a suprarenal Bird's nest inferior vena cava filter. The patient tolerated the procedure well and had extensive tumor infarction including the tumor thrombus on 6-month follow-up computed tomography

  12. Photo-elastic properties of the wing imaginal disc of Drosophila.

    Science.gov (United States)

    Schluck, T; Aegerter, C M

    2010-10-01

    In the study of developmental biology, the physical properties and constraints of the developing tissues are of great importance. In spite of this, not much is known about the elastic properties of biologically relevant tissues that are studied in biology labs. Here, we characterize properties of the wing imaginal disc of Drosophila, which is a precursor organ intensely studied in the framework of growth control and cell polarity. In order to determine the possibility of measuring mechanical stresses inside the tissue during development, we quantify the photo-elastic properties of the tissue by direct mechanical manipulation. We obtain a photo-elastic constant of 2 x 10(-10) Pa(-1).

  13. Performance Assessment in a Heat Exchanger Tube with Opposite/Parallel Wing Twisted Tapes

    Directory of Open Access Journals (Sweden)

    S. Eiamsa-ard

    2015-02-01

    Full Text Available The thermohydraulic performance in a tube containing a modified twisted tape with alternate-axes and wing arrangements is reported. This work aims to investigate the effects of wing arrangements (opposite (O and parallel (P wings at different wing shapes (triangle (Tri, rectangular (Rec, and trapezoidal (Tra wings and on the thermohydraulic performance characteristics. The obtained results show that wing twisted tapes with all wing shape arrangements (O-Tri/O-Rec/O-Tra/P-Tri/P-Rec/P-Tra give superior thermohydraulic performance and heat transfer rate to the typical twisted tape. In addition, the tapes with opposite wing arrangement of O-Tra, O-Rec, and O-Tri give superior thermohydraulic performances to those with parallel wing arrangement of P-Tra, P-Rec, and P-Tri around 2.7%, 3.5%, and 3.2%, respectively.

  14. Analysis of Low Speed Stall Aerodynamics of a Swept Wing with Laminar Flow Glove

    Science.gov (United States)

    Bui, Trong T.

    2014-01-01

    Reynolds-Averaged Navier-Stokes (RANS) computational fluid dynamics (CFD) analysis was conducted to study the low-speed stall aerodynamics of a GIII aircraft's swept wing modified with a laminar-flow wing glove. The stall aerodynamics of the gloved wing were analyzed and compared with the unmodified wing for the flight speed of 120 knots and altitude of 2300 ft above mean sea level (MSL). The Star-CCM+ polyhedral unstructured CFD code was first validated for wing stall predictions using the wing-body geometry from the First American Institute of Aeronautics and Astronautics (AIAA) CFD High-Lift Prediction Workshop. It was found that the Star-CCM+ CFD code can produce results that are within the scattering of other CFD codes considered at the workshop. In particular, the Star-CCM+ CFD code was able to predict wing stall for the AIAA wing-body geometry to within 1 degree of angle of attack as compared to benchmark wind-tunnel test data. Current results show that the addition of the laminar-flow wing glove causes the gloved wing to stall much earlier than the unmodified wing. Furthermore, the gloved wing has a different stall characteristic than the clean wing, with no sharp lift drop-off at stall for the gloved wing.

  15. Analysis of Low-Speed Stall Aerodynamics of a Swept Wing with Laminar-Flow Glove

    Science.gov (United States)

    Bui, Trong T.

    2014-01-01

    Reynolds-Averaged Navier-Stokes (RANS) computational fluid dynamics (CFD) analysis was conducted to study the low-speed stall aerodynamics of a GIII aircraft's swept wing modified with a laminar-flow wing glove. The stall aerodynamics of the gloved wing were analyzed and compared with the unmodified wing for the flight speed of 120 knots and altitude of 2300 ft above mean sea level (MSL). The Star-CCM+ polyhedral unstructured CFD code was first validated for wing stall predictions using the wing-body geometry from the First American Institute of Aeronautics and Astronautics (AIAA) CFD High-Lift Prediction Workshop. It was found that the Star-CCM+ CFD code can produce results that are within the scattering of other CFD codes considered at the workshop. In particular, the Star-CCM+ CFD code was able to predict wing stall for the AIAA wing-body geometry to within 1 degree of angle of attack as compared to benchmark wind-tunnel test data. Current results show that the addition of the laminar-flow wing glove causes the gloved wing to stall much earlier than the unmodified wing. Furthermore, the gloved wing has a different stall characteristic than the clean wing, with no sharp lift drop-off at stall for the gloved wing.

  16. Effects of flexibility and aspect ratio on the aerodynamic performance of flapping wings.

    Science.gov (United States)

    Fu, Junjiang; Liu, Xiaohui; Shyy, Wei; Qiu, Huihe

    2018-01-26

    In the current study, we experimentally investigated the flexibility effects on the aerodynamic performance of flapping wings and the correlation with aspect ratio at angle of attack α = 45o. The Reynolds number based on the chord length and the wing tip velocity is maintained at Re = 5.3x103. Our result for compliant wings with an aspect ratio of 4 shows that wing flexibility can offer improved aerodynamic performance compared to that of a rigid wing. Flexible wings are found to offer higher lift-to-drag ratios; in particular, there is significant reduction in drag with little compromise in lift. The mechanism of the flexibility effects on the aerodynamic performance is addressed by quantifying the aerodynamic lift and drag forces, the transverse displacement on the wings and the flow field around the wings. The regime of the effective stiffness that offers improved aerodynamic performance is quantified in a range of about 0.5~10 and it matches the stiffness of insect wings with similar aspect ratios. Furthermore, we find that the aspect ratio of the wing is the predominant parameter determining the flexibility effects of compliant wings. Compliant wings with an aspect ratio of two do not demonstrate improved performance compared to their rigid counterparts throughout the entire stiffness regime investigated. The correlation between wing flexibility effects and the aspect ratio is supported by the stiffness of real insect wings. © 2018 IOP Publishing Ltd.

  17. Terminology for pregnancy loss prior to viability

    DEFF Research Database (Denmark)

    Kolte, A M; Bernardi, L A; Christiansen, O B

    2015-01-01

    Pregnancy loss prior to viability is common and research in the field is extensive. Unfortunately, terminology in the literature is inconsistent. The lack of consensus regarding nomenclature and classification of pregnancy loss prior to viability makes it difficult to compare study results from d...

  18. Improving Open Access through Prior Learning Assessment

    Science.gov (United States)

    Yin, Shuangxu; Kawachi, Paul

    2013-01-01

    This paper explores and presents new data on how to improve open access in distance education through using prior learning assessments. Broadly there are three types of prior learning assessment (PLAR): Type-1 for prospective students to be allowed to register for a course; Type-2 for current students to avoid duplicating work-load to gain…

  19. Relationship between Prior Knowledge and Reading Comprehension

    Science.gov (United States)

    Abdelaal, Noureldin Mohamed; Sase, Amal Saleh

    2014-01-01

    This study investigates the relationship between prior knowledge and reading comprehension in second language among postgraduate students in UPM. Participants in the study were 20 students who have the same level in English as a second language from several faculties. On the basis of a prior-knowledge questionnaire and test, students were…

  20. Myeloablative radioimmunotherapies in the conditioning of patients with AML, MDS and multiple myeloma prior to stem cell transplantation; Myeloablative Radioimmuntherapien zur Konditionierung bei Patienten mit AML, MDS und multiplem Myelom vor Stammzelltransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Buchmann, I. [Abt. fuer Nuklearmedizin, Universitaetsklinik Heidelberg (Germany)

    2008-06-15

    Aggressive consolidation chemotherapy and hematopoietic stem cell transplantation have improved the prognosis of patients with acute myeloid leukemia (AML), myelodyplastic syndrome (MDS) and multiple myeloma. Nevertheless, only a minor fraction of patients achieve long-term disease-free survival after stem cell transplantation with disease recurrence being the most common cause of treatment failure. In addition, therapy-related effects such as toxicity of chemotherapy and complications of stem cell transplantation increase mortality rates significantly. Myeloablative radioimmunotherapy uses radiolabeled monoclonal antibodies (mAb) with affinity for the hematopoietic marrow. It applies high radiation doses in the bone marrow but spares normal organs. Adding myeloablative radioimmunotherapy to the conditioning schemes of AML, MDS and multiple myeloma before stem cell transplantation allows for the achievement of a pronounced antileukemic/antimyeloma effect for the reduction of relapse rates without significant increase of acute organ toxicity and therapy-related mortality. In order to optimise therapy, a rational design of the nuclide-antibody combination is necessary. {sup 90}Y, {sup 188}Re and {sup 131}I are the most frequently used {beta}{sup -}-particles. Of these, {sup 90}Y is the most qualified nuclide for myeloablation. Backbone stabilised DTPA are ideal chelators to stably conjugate {sup 90}Y to antibodies so far. For myeloablative conditioning, anti-CD66-, -45- and -33-mAb are used. The anti-CD66-antibody BW250/183 binds to normal hematopoietic cells but not to leukemic blasts and myeloma cells. The {sup 90}Y-2B3M-DTPA-BW250/183 is the most suited radioimmunoconjugate for patients with an infiltration grade of leukemic blasts in the bone marrow < 25%. The specific doses (Gy/GBq) are 10.2 {+-} 1.8 (bone marrow), 2.7 {+-} 2 (liver) and < 1 (kidneys). In contrast, radiolabeled anti-CD33- and anti-CD45-antibodies bind to both, most of white blood cells and

  1. The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation

    Directory of Open Access Journals (Sweden)

    Chakradhara Rao S. Uppugunduri

    2017-07-01

    Full Text Available Hemorrhagic cystitis (HC is one of the complications of busulfan-cyclophosphamide (BU-CY conditioning regimen during allogeneic hematopoietic stem cell transplantation (HSCT in children. Identifying children at high risk of developing HC in a HSCT setting could facilitate the evaluation and implementation of effective prophylactic measures. In this retrospective analysis genotyping of selected candidate gene variants was performed in 72 children and plasma Sulfolane (Su, water soluble metabolite of BU levels were measured in 39 children following treatment with BU-CY regimen. The cytotoxic effects of Su and acrolein (Ac, water soluble metabolite of CY were tested on human urothelial cells (HUCs. The effect of Su was also tested on cytochrome P 450 (CYP function in HepaRG hepatic cells. Cumulative incidences of HC before day 30 post HSCT were estimated using Kaplan–Meier curves and log-rank test was used to compare the difference between groups in a univariate analysis. Multivariate Cox regression was used to estimate hazard ratios with 95% confidence intervals (CIs. Multivariate analysis included co-variables that were significantly associated with HC in a univariate analysis. Cumulative incidence of HC was 15.3%. In the univariate analysis, HC incidence was significantly (p < 0.05 higher in children older than 10 years (28.6 vs. 6.8% or in children with higher Su levels (>40 vs. <11% or in carriers of both functional GSTM1 and CYP2C9 (33.3 vs. 6.3% compared to the other group. In a multivariate analysis, combined GSTM1 and CYP2C9 genotype status was associated with HC occurrence with a hazards ratio of 4.8 (95% CI: 1.3–18.4; p = 0.02. Ac was found to be toxic to HUC cells at lower concentrations (33 μM, Su was not toxic to HUC cells at concentrations below 1 mM and did not affect CYP function in HepaRG cells. Our observations suggest that pre-emptive genotyping of CYP2C9 and GSTM1 may aid in selection of more effective prophylaxis to

  2. Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.

    Science.gov (United States)

    Nguyen, Duy; Fayol, Olivier; Buisine, Nicolas; Lecorre, Pierrette; Uguen, Patricia

    2016-01-01

    Studying the dynamic of gene regulatory networks is essential in order to understand the specific signals and factors that govern cell proliferation and differentiation during development. This also has direct implication in human health and cancer biology. The general transcriptional elongation regulator P-TEFb regulates the transcriptional status of many developmental genes. Its biological activity is controlled by an inhibitory complex composed of HEXIM and the 7SK snRNA. Here, we examine the function of HEXIM during Drosophila development. Our key finding is that HEXIM affects the Hedgehog signaling pathway. HEXIM knockdown flies display strong phenotypes and organ failures. In the wing imaginal disc, HEXIM knockdown initially induces ectopic expression of Hedgehog (Hh) and its transcriptional effector Cubitus interuptus (Ci). In turn, deregulated Hedgehog signaling provokes apoptosis, which is continuously compensated by apoptosis-induced cell proliferation. Thus, the HEXIM knockdown mutant phenotype does not result from the apoptotic ablation of imaginal disc; but rather from the failure of dividing cells to commit to a proper developmental program due to Hedgehog signaling defects. Furthermore, we show that ci is a genetic suppressor of hexim. Thus, HEXIM ensures the integrity of Hedgehog signaling in wing imaginal disc, by a yet unknown mechanism. To our knowledge, this is the first time that the physiological function of HEXIM has been addressed in such details in vivo.

  3. Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.

    Directory of Open Access Journals (Sweden)

    Duy Nguyen

    Full Text Available Studying the dynamic of gene regulatory networks is essential in order to understand the specific signals and factors that govern cell proliferation and differentiation during development. This also has direct implication in human health and cancer biology. The general transcriptional elongation regulator P-TEFb regulates the transcriptional status of many developmental genes. Its biological activity is controlled by an inhibitory complex composed of HEXIM and the 7SK snRNA. Here, we examine the function of HEXIM during Drosophila development. Our key finding is that HEXIM affects the Hedgehog signaling pathway. HEXIM knockdown flies display strong phenotypes and organ failures. In the wing imaginal disc, HEXIM knockdown initially induces ectopic expression of Hedgehog (Hh and its transcriptional effector Cubitus interuptus (Ci. In turn, deregulated Hedgehog signaling provokes apoptosis, which is continuously compensated by apoptosis-induced cell proliferation. Thus, the HEXIM knockdown mutant phenotype does not result from the apoptotic ablation of imaginal disc; but rather from the failure of dividing cells to commit to a proper developmental program due to Hedgehog signaling defects. Furthermore, we show that ci is a genetic suppressor of hexim. Thus, HEXIM ensures the integrity of Hedgehog signaling in wing imaginal disc, by a yet unknown mechanism. To our knowledge, this is the first time that the physiological function of HEXIM has been addressed in such details in vivo.

  4. Aerodynamics and Ecomorphology of Flexible Feathers and Morphing Bird Wings

    Science.gov (United States)

    Klaassen van Oorschot, Brett

    Birds are talented fliers capable of vertical take-off and landing, navigating turbulent air, and flying thousands of miles without rest. How is this possible? What allows birds to exploit the aerial environment with such ease? In part, it may be because bird wings are unlike any engineered wing. They are flexible, strong, lightweight, and dynamically capable of changes in shape on a nearly instantaneous basis (Rayner, 1988; Tobalske, 2007). Moreover, much of this change is passive, modulated only by changes in airflow angle and velocity. Birds actively morph their wings and their feathers morph passively in response to airflow to meet aerodynamic demands. Wings are highly adapted to myriad aeroecological factors and aerodynamic conditions (e.g. Lockwood et al., 1998; Bowlin and Winkler, 2004). This dissertation contains the results of my research on the complexities of morphing avian wings and feathers. I chose to study three related-but-discrete aspects of the avian wing: 1) the aerodynamics of morphing wings during take-off and gliding flight, 2) the presence and significance of wing tip slots across the avian clade, and 3) the aerodynamic role of the emarginate primary feathers that form these wing tip slots. These experiments ask fundamental questions that have intrigued me since childhood: Why do birds have different wing shapes? And why do some birds have slotted wing tips? It's fair to say that you will not find definitive answers here--rather, you will find the methodical, incremental addition of new hypotheses and empirical evidence which will serve future researchers in their own pursuits of these questions. The first chapter explores active wing morphing in two disparate aerodynamic regimes: low-advance ratio flapping (such as during takeoff) and high-advance ratio gliding. This chapter was published in the Journal of Experimental Biology (Klaassen van Oorschot et al., 2016) with the help of an undergraduate researcher, Emily Mistick. We found that wing

  5. Assessment of the correlation between wing size and body weight in captive Culex quinquefasciatus

    Directory of Open Access Journals (Sweden)

    Vivian Petersen

    Full Text Available Abstract: INTRODUCTION: Mass production of mosquitoes under laboratory conditions allows implementing methods to control vector mosquitoes. Colony development depends on mosquito size and weight. Body size can be estimated from its correlation with wing size, whereas weight is more difficult to determine. Our goal was to test whether wing size can predict the weight. METHODS: We compared dry weight and wing centroid size of Culex quinquefasciatus reared at different temperatures and four diets. RESULTS: Weight and wing size were strongly correlated. The diets did not influence wing size. CONCLUSIONS: Wing centroid size is a good predictor of Cx. quinquefasciatus body weight.

  6. Analysis of Low-Speed Stall Aerodynamics of a Business Jets Wing Using STAR-CCM+

    Science.gov (United States)

    Bui, Trong

    2016-01-01

    Reynolds-Averaged Navier-Stokes (RANS) computational fluid dynamics (CFD) analysis was conducted: to study the low-speed stall aerodynamics of a GIII aircrafts swept wing modified with (1) a laminar-flow wing glove, or (2) a seamless flap. The stall aerodynamics of these two different wing configurations were analyzed and compared with the unmodified baseline wing for low-speed flight. The Star-CCM+ polyhedral unstructured CFD code was first validated for wing stall predictions using the wing-body geometry from the First AIAA CFD High-Lift Prediction Workshop.

  7. Assessment of the correlation between wing size and body weight in captive Culex quinquefasciatus.

    Science.gov (United States)

    Petersen, Vivian; Marchi, Marco Jacometto; Natal, Delsio; Marrelli, Mauro Toledo; Barbosa, Admilson Clayton; Suesdek, Lincoln

    2016-01-01

    Mass production of mosquitoes under laboratory conditions allows implementing methods to control vector mosquitoes. Colony development depends on mosquito size and weight. Body size can be estimated from its correlation with wing size, whereas weight is more difficult to determine. Our goal was to test whether wing size can predict the weight. We compared dry weight and wing centroid size of Culex quinquefasciatus reared at different temperatures and four diets. Weight and wing size were strongly correlated. The diets did not influence wing size. Wing centroid size is a good predictor of Cx. quinquefasciatus body weight.

  8. Aeroelasticity Benchmark Assessment: Subsonic Fixed Wing Program

    Science.gov (United States)

    Florance, Jennifer P.; Chwalowski, Pawel; Wieseman, Carol D.

    2010-01-01

    Aeroelasticity Branch will examine other experimental efforts within the Subsonic Fixed Wing (SFW) program (such as testing of the NASA Common Research Model (CRM)) and other NASA programs and assess aeroelasticity issues and research topics.

  9. Sex Differences in 20-Hydroxyecdysone Hormone Levels Control Sexual Dimorphism in Bicyclus anynana Wing Patterns.

    Science.gov (United States)

    Bhardwaj, Shivam; Prudic, Kathleen L; Bear, Ashley; Dasgupta, Mainak; Wasik, Bethany R; Tong, Xiaoling; Cheong, Wei Fun; Wenk, Markus R; Monteiro, Antónia

    2018-02-01

    In contrast to the important role of hormones in the development of sexual traits in vertebrates (Cox RM, Stenquist DS, Calsbeek R. 2009. Testosterone, growth and the evolution of sexual size dimorphism. J Evol Biol. 22(8):1586-1598.), the differentiation of these traits in insects is attributed almost exclusively to cell-autonomous mechanisms controlled by members of the sex determination pathway (Verhulst EC, van de Zande L. 2015. Double nexus - doublesex is the connecting element in sex determination. Brief Funct Genomics 14(6):396-406.), such as doublesex. Although hormones can shape the development of sexual traits in insects, variation in hormone levels are not conclusively known to cause dimorphism in these traits (Prakash A, Monteiro A. 2016. Molecular mechanisms of secondary sexual trait development in insects. Curr Opin Insect Sci. 17:40-48.). Here, we show that butterflies use sex-specific differences in 20-hydroxyecdysone hormone titers to create sexually dimorphic wing ornaments. Females of the dry season (DS) form of Bicyclus anynana display a larger sexual ornament on their wings than males, whereas in the wet season form both sexes have similarly sized ornaments (Prudic KL, Jeon C, Cao H, Monteiro A. 2011. Developmental plasticity in sexual roles of butterfly species drives mutual sexual ornamentation. Science 331(6013):73-75.). High levels of circulating 20-hydroxyecdysone during larval development in DS females and wet season forms cause proliferation of the cells fated to give rise to this wing ornament, and results in sexual dimorphism in the DS forms. This study advances our understanding of how the environment regulates sex-specific patterns of plasticity of sexual ornaments and conclusively shows that hormones can play a role in the development of secondary sexual traits in insects, just like they do in vertebrates. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  10. Aerodynamics of wing-assisted incline running in birds.

    Science.gov (United States)

    Tobalske, Bret W; Dial, Kenneth P

    2007-05-01

    Wing-assisted incline running (WAIR) is a form of locomotion in which a bird flaps its wings to aid its hindlimbs in climbing a slope. WAIR is used for escape in ground birds, and the ontogeny of this behavior in precocial birds has been suggested to represent a model analogous to transitional adaptive states during the evolution of powered avian flight. To begin to reveal the aerodynamics of flap-running, we used digital particle image velocimetry (DPIV) and measured air velocity, vorticity, circulation and added mass in the wake of chukar partridge Alectoris chukar as they engaged in WAIR (incline 65-85 degrees; N=7 birds) and ascending flight (85 degrees, N=2). To estimate lift and impulse, we coupled our DPIV data with three-dimensional wing kinematics from a companion study. The ontogeny of lift production was evaluated using three age classes: baby birds incapable of flight [6-8 days post hatching (d.p.h.)] and volant juveniles (25-28 days) and adults (45+ days). All three age classes of birds, including baby birds with partially emerged, symmetrical wing feathers, generated circulation with their wings and exhibited a wake structure that consisted of discrete vortex rings shed once per downstroke. Impulse of the vortex rings during WAIR was directed 45+/-5 degrees relative to horizontal and 21+/-4 degrees relative to the substrate. Absolute values of circulation in vortex cores and induced velocity increased with increasing age. Normalized circulation was similar among all ages in WAIR but 67% greater in adults during flight compared with flap-running. Estimated lift during WAIR was 6.6% of body weight in babies and between 63 and 86% of body weight in juveniles and adults. During flight, average lift was 110% of body weight. Our results reveal for the first time that lift from the wings, rather than wing inertia or profile drag, is primarily responsible for accelerating the body toward the substrate during WAIR, and that partially developed wings, not yet

  11. Age-class separation of blue-winged ducks

    Science.gov (United States)

    Hohman, W.L.; Moore, J.L.; Twedt, D.J.; Mensik, John G.; Logerwell, E.

    1995-01-01

    Accurate determination of age is of fundamental importance to population and life history studies of waterfowl and their management. Therefore, we developed quantitative methods that separate adult and immature blue-winged teal (Anas discors), cinnamon teal (A. cyanoptera), and northern shovelers (A. clypeata) during spring and summer. To assess suitability of discriminant models using 9 remigial measurements, we compared model performance (% agreement between predicted age and age assigned to birds on the basis of definitive cloacal or rectral feather characteristics) in different flyways (Mississippi and Pacific) and between years (1990-91 and 1991-92). We also applied age-classification models to wings obtained from U.S. Fish and Wildlife Service harvest surveys in the Mississippi and Central-Pacific flyways (wing-bees) for which age had been determined using qualitative characteristics (i.e., remigial markings, shape, or wear). Except for male northern shovelers, models correctly aged lt 90% (range 70-86%) of blue-winged ducks. Model performance varied among species and differed between sexes and years. Proportions of individuals that were correctly aged were greater for males (range 63-86%) than females (range 39-69%). Models for northern shovelers performed better in flyway comparisons within year (1991-92, La. model applied to Calif. birds, and Calif. model applied to La. birds: 90 and 94% for M, and 89 and 76% for F, respectively) than in annual comparisons within the Mississippi Flyway (1991-92 model applied to 1990-91 data: 79% for M, 50% for F). Exclusion of measurements that varied by flyway or year did not improve model performance. Quantitative methods appear to be of limited value for age separation of female blue-winged ducks. Close agreement between predicted age and age assigned to wings from the wing-bees suggests that qualitative and quantitative methods may be equally accurate for age separation of male blue-winged ducks. We interpret annual

  12. Unsteady Flow Interactions Between Pitching Wings In Schooling Arrangements

    Science.gov (United States)

    Kurt, Melike; Moored, Keith

    2017-11-01

    In nature, many fish aggregate into large groups or schools for protection against predators, for social interactions and to save energy during migrations. Regardless of their prime motivation, fish experience three-dimensional flow interactions amongst themselves that can improve or hamper swimming performance and give rise to fluid-mediated forces between individuals. To date, the unsteady, three-dimensional flow interactions among schooling fish remains relatively unexplored. In order to study these interactions, the caudal fins of two interacting fish are idealized as two finite span pitching wings arranged in mixtures of canonical in-line and side-by-side arrangements. The forces and moments acting on the wings in the streamwise and cross-stream directions are quantified as the arrangement and the phase delay between the wings is altered. Particle image velocimetry is employed to characterize the flow physics during high efficiency locomotion. Finally, the forces and flowfields of two-dimensional pitching wings are compared with three-dimensional wings to distinguish how three-dimensionality alters the flow interactions in schools of fish.

  13. Imaging optical scattering of butterfly wing scales with a microscope.

    Science.gov (United States)

    Fu, Jinxin; Yoon, Beom-Jin; Park, Jung Ok; Srinivasarao, Mohan

    2017-08-06

    A new optical method is proposed to investigate the reflectance of structurally coloured objects, such as Morpho butterfly wing scales and cholesteric liquid crystals. Using a reflected-light microscope and a digital single-lens reflex (DSLR) camera, we have successfully measured the two-dimensional reflection pattern of individual wing scales of Morpho butterflies. We demonstrate that this method enables us to measure the bidirectional reflectance distribution function (BRDF). The scattering image observed in the back focal plane of the objective is projected onto the camera sensor by inserting a Bertrand lens in the optical path of the microscope. With monochromatic light illumination, we quantify the angle-dependent reflectance spectra from the wing scales of Morpho rhetenor by retrieving the raw signal from the digital camera sensor. We also demonstrate that the polarization-dependent reflection of individual wing scales is readily observed using this method, using the individual wing scales of Morpho cypris . In an effort to show the generality of the method, we used a chiral nematic fluid to illustrate the angle-dependent reflectance as seen by this method.

  14. Multidisciplinary Shape Optimization of a Composite Blended Wing Body Aircraft

    Science.gov (United States)

    Boozer, Charles Maxwell

    A multidisciplinary shape optimization tool coupling aerodynamics, structure, and performance was developed for battery powered aircraft. Utilizing high-fidelity computational fluid dynamics analysis tools and a structural wing weight tool, coupled based on the multidisciplinary feasible optimization architecture; aircraft geometry is modified in the optimization of the aircraft's range or endurance. The developed tool is applied to three geometries: a hybrid blended wing body, delta wing UAS, the ONERA M6 wing, and a modified ONERA M6 wing. First, the optimization problem is presented with the objective function, constraints, and design vector. Next, the tool's architecture and the analysis tools that are utilized are described. Finally, various optimizations are described and their results analyzed for all test subjects. Results show that less computationally expensive inviscid optimizations yield positive performance improvements using planform, airfoil, and three-dimensional degrees of freedom. From the results obtained through a series of optimizations, it is concluded that the newly developed tool is both effective at improving performance and serves as a platform ready to receive additional performance modules, further improving its computational design support potential.

  15. Evaluation of Aircraft Wing-Tip Vortex Using PIV

    Science.gov (United States)

    Alsayed, Omer A.; Asrar, Waqar; Omar, Ashraf A.

    2010-06-01

    The formation and development of a wing-tip vortex in a near and extended near filed were studied experimentally. Particle image velocimetry was used in a wind tunnel to measure the tip vortex velocity field and hence investigate the flow structure in a wake of aircraft half-wing model. The purpose of this investigation is to evaluate the main features of the lift generated vortices in order to find ways to alleviate hazardous wake vortex encounters for follower airplanes during start and approach such that the increase in airport capacity can be achieved. First the wake structure at successive downstream planes crosswise to the axis of the wake vortices was investigated by measuring parameters such as core radius, maximum tangential velocities, vorticities and circulation distributions. The effect of different angles of attack setting on vortex parameters was examined at one downstream location. In very early stages the vortex sheet evolution makes the tip vortex to move inward and to the suction side of the wing. While the core radius and circulation distributions hardly vary with the downstream distance, noticeable differences for the same vortex parameters at different angles of attack settings were observed. The center of the wing tip vortices scatter in a circle of radius nearly equal to 1% of the mean wing chord and wandering amplitudes shows no direct dependence on the vortex strength but linearly increase with the downstream distance.

  16. Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: A retrospective survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.

    Science.gov (United States)

    Martino, Rodrigo; Parody, Rocio; Fukuda, Takahiro; Maertens, Johan; Theunissen, Koen; Ho, Aloysius; Mufti, Ghulam J; Kroger, Nicolaus; Zander, Arnold R; Heim, Dominik; Paluszewska, Monika; Selleslag, Dominik; Steinerova, Katerina; Ljungman, Per; Cesaro, Simone; Nihtinen, Anna; Cordonnier, Catherine; Vazquez, Lourdes; López-Duarte, Monica; Lopez, Javier; Cabrera, Rafael; Rovira, Montserrat; Neuburger, Stefan; Cornely, Oliver; Hunter, Ann E; Marr, Kieren A; Dornbusch, Hans Jürgen; Einsele, Hermann

    2006-11-01

    In this retrospective study, we analyzed the outcomes of 129 patients who underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT) and had a history of probable or proven invasive aspergillosis (IA), of whom 57 (44%) received a reduced-intensity conditioning (RIC). Overall, 27 patients with IA progressed after the allo-HSCT (cumulative incidence [CumInc] at 2 years, 22%). The variables that increased the 2-year CumInc of IA progression were (1) longer duration of neutropenia after transplantation; (2) advanced status of the underlying disease; and (3) less than 6 weeks from start of systemic anti-Aspergillus therapy and the allo-HSCT. In addition, (4) conventional myeloablative conditioning increased the risk of progression early after transplantation (before day 30) only, while 3 variables increased the risk beyond day 30 were (5) cytomegalovirus disease; (6) bone marrow or cord blood as source of stem cells; and (7) grades II to IV acute graft-versus-host disease (GVHD). A risk model for progression was generated, defined as low (0-1 risk factors, 6% incidence), intermediate (2-3 risk factors, 27% incidence), or high risk (> or = 3 risk factors, 72% incidence [P < .001]). These findings may help in the interpretation and design of future studies on secondary prophylaxis of IA after an allo-HSCT.

  17. Aerodynamic performance of a hovering hawkmoth with flexible wings: a computational approach

    Science.gov (United States)

    Nakata, Toshiyuki; Liu, Hao

    2012-01-01

    Insect wings are deformable structures that change shape passively and dynamically owing to inertial and aerodynamic forces during flight. It is still unclear how the three-dimensional and passive change of wing kinematics owing to inherent wing flexibility contributes to unsteady aerodynamics and energetics in insect flapping flight. Here, we perform a systematic fluid-structure interaction based analysis on the aerodynamic performance of a hovering hawkmoth, Manduca, with an integrated computational model of a hovering insect with rigid and flexible wings. Aerodynamic performance of flapping wings with passive deformation or prescribed deformation is evaluated in terms of aerodynamic force, power and efficiency. Our results reveal that wing flexibility can increase downwash in wake and hence aerodynamic force: first, a dynamic wing bending is observed, which delays the breakdown of leading edge vortex near the wing tip, responsible for augmenting the aerodynamic force-production; second, a combination of the dynamic change of wing bending and twist favourably modifies the wing kinematics in the distal area, which leads to the aerodynamic force enhancement immediately before stroke reversal. Moreover, an increase in hovering efficiency of the flexible wing is achieved as a result of the wing twist. An extensive study of wing stiffness effect on aerodynamic performance is further conducted through a tuning of Young's modulus and thickness, indicating that insect wing structures may be optimized not only in terms of aerodynamic performance but also dependent on many factors, such as the wing strength, the circulation capability of wing veins and the control of wing movements. PMID:21831896

  18. Do hummingbirds use a different mechanism than insects to flip and twist their wings?

    Science.gov (United States)

    Song, Jialei; Luo, Haoxiang; Hedrick, Tyson

    2014-11-01

    Hovering hummingbirds flap their wings in an almost horizontal stroke plane and flip the wings to invert the angle of attack after stroke reversal, a strategy also utilized by many hovering insects such as fruit flies. However, unlike insects whose wing actuation mechanism is only located at the base, hummingbirds have a vertebrate musculoskeletal system and their wings contain bones and muscles and thus, they may be capable of both actively flipping and twisting their wings. To investigate this issue, we constructed a hummingbird wing model and study its pitching dynamics. The wing kinematics are reconstructed from high-speed imaging data, and the inertial torques are calculated in a rotating frame of reference using mass distribution data measured from dissections of hummingbird wings. Pressure data from a previous CFD study of the same wing kinematics are used to calculate the aerodynamic torque. The results show that like insect wings, the hummingbird wing pitching is driven by its own inertia during reversal, and the aerodynamic torque is responsible for wing twist during mid-stroke. In conclusion, our study suggests that their wing dynamics are very similar even though their actuation systems are entirely different. This research was supported by the NSF.

  19. Short revolving wings enable hovering animals to avoid stall and reduce drag

    Science.gov (United States)

    Lentink, David; Kruyt, Jan W.; Heijst, Gertjan F.; Altshuler, Douglas L.

    2014-11-01

    Long and slender wings reduce the drag of airplanes, helicopters, and gliding animals, which operate at low angle of attack (incidence). Remarkably, there is no evidence for such influence of wing aspect ratio on the energetics of hovering animals that operate their wings at much higher incidence. High incidence causes aircraft wings to stall, hovering animals avoid stall by generating an attached vortex along the leading edge of their wings that elevates lift. Hypotheses that explain this capability include the necessity for a short radial distance between the shoulder joint and wing tip, measured in chord lengths, instead of the long tip-to-tip distance that elevates aircraft performance. This stems from how hovering animals revolve their wings around a joint, a condition for which the precise effect of aspect ratio on stall performance is unknown. Here we show that the attachment of the leading edge vortex is determined by wing aspect ratio with respect to the center of rotation-for a suite of aspect ratios that represent both animal and aircraft wings. The vortex remains attached when the local radius is shorter than 4 chord lengths, and separates outboard on more slender wings. Like most other hovering animals, hummingbirds have wing aspect ratios between 3 and 4, much stubbier than helicopters. Our results show this makes their wings robust against flow separation, which reduces drag below values obtained with more slender wings. This revises our understanding of how aspect ratio improves performance at low Reynolds numbers.

  20. Interpretation training influences memory for prior interpretations

    NARCIS (Netherlands)

    Salemink, E.; Hertel, P.; Mackintosh, B.

    2010-01-01

    Anxiety is associated with memory biases when the initial interpretation of the event is taken into account. This experiment examined whether modification of interpretive bias retroactively affects memory for prior events and their initial interpretation. Before training, participants imagined

  1. Prior Authorization of PMDs Demonstration - Status Update

    Data.gov (United States)

    U.S. Department of Health & Human Services — CMS implemented a Prior Authorization process for scooters and power wheelchairs for people with Fee-For-Service Medicare who reside in seven states with high...

  2. Effect of leading- and trailing-edge flaps on clipped delta wings with and without wing camber at supersonic speeds

    Science.gov (United States)

    Hernandez, Gloria; Wood, Richard M.; Covell, Peter F.

    1994-01-01

    An experimental investigation of the aerodynamic characteristics of thin, moderately swept fighter wings has been conducted to evaluate the effect of camber and twist on the effectiveness of leading- and trailing-edge flaps at supersonic speeds in the Langley Unitary Plan Wind Tunnel. The study geometry consisted of a generic fuselage with camber typical of advanced fighter designs without inlets, canopy, or vertical tail. The model was tested with two wing configurations an uncambered (flat) wing and a cambered and twisted wing. Each wing had an identical clipped delta planform with an inboard leading edge swept back 65 deg and an outboard leading edge swept back 50 deg. The trailing edge was swept forward 25 deg. The leading-edge flaps were deflected 4 deg to 15 deg, and the trailing-edge flaps were deflected from -30 deg to 10 deg. Longitudinal force and moment data were obtained at Mach numbers of 1.60, 1.80, 2.00, and 2.16 for an angle-of-attack range 4 deg to 20 deg at a Reynolds number of 2.16 x 10(exp 6) per foot and for an angle-of-attack range 4 deg to 20 deg at a Reynolds number of 2.0 x 10(exp 6) per foot. Vapor screen, tuft, and oil flow visualization data are also included.

  3. Longer wings for faster springs - wing length relates to spring phenology in a long-distance migrant across its range.

    Science.gov (United States)

    Hahn, Steffen; Korner-Nievergelt, Fränzi; Emmenegger, Tamara; Amrhein, Valentin; Csörgő, Tibor; Gursoy, Arzu; Ilieva, Mihaela; Kverek, Pavel; Pérez-Tris, Javier; Pirrello, Simone; Zehtindjiev, Pavel; Salewski, Volker

    2016-01-01

    In migratory birds, morphological adaptations for efficient migratory flight often oppose morphological adaptations for efficient behavior during resident periods. This includes adaptations in wing shape for either flying long distances or foraging in the vegetation and in climate-driven variation of body size. In addition, the timing of migratory flights and particularly the timely arrival at local breeding sites is crucial because fitness prospects depend on site-specific phenology. Thus, adaptations for efficient long-distance flights might be also related to conditions at destination areas. For an obligatory long-distance migrant, the common nightingale, we verified that wing length as the aerodynamically important trait, but not structural body size increased from the western to the eastern parts of the species range. In contrast with expectation from aerodynamic theory, however, wing length did not increase with increasing migration distances. Instead, wing length was associated with the phenology at breeding destinations, namely the speed of local spring green-up. We argue that longer wings are beneficial for adjusting migration speed to local conditions for birds breeding in habitats with fast spring green-up and thus short optimal arrival periods. We suggest that the speed of spring green-up at breeding sites is a fundamental variable determining the timing of migration that fine tune phenotypes in migrants across their range.

  4. Leading-edge vortex shedding from rotating wings

    Energy Technology Data Exchange (ETDEWEB)

    Kolomenskiy, Dmitry [Centre de Recherches Mathématiques (CRM), Department of Mathematics and Statistics, McGill University, 805 Sherbrooke W., Montreal, QC H3A 0B9 (Canada); Elimelech, Yossef [Faculty of Aerospace Engineering, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Schneider, Kai, E-mail: dkolom@gmail.com [M2P2–CNRS, Université d' Aix-Marseille, 39, rue Frédéric Joliot-Curie, F-13453 Marseille Cedex 13 (France)

    2014-06-01

    This paper presents a numerical investigation of the leading-edge vortices generated by rotating triangular wings at Reynolds number Re = 250. A series of three-dimensional numerical simulations have been carried out using a Fourier pseudo-spectral method with volume penalization. The transition from stable attachment of the leading-edge vortex to periodic vortex shedding is explored, as a function of the wing aspect ratio and the angle of attack. It is found that, in a stable configuration, the spanwise flow in the recirculation bubble past the wing is due to the centrifugal force, incompressibility and viscous stresses. For the flow outside of the bubble, an inviscid model of spanwise flow is presented. (papers)

  5. An overview of two nonlinear supersonic wing design studies

    Science.gov (United States)

    Miller, D. S.; Pittman, J. L.; Wood, R. M.

    1983-01-01

    The progress of two studies which apply nonlinear aerodynamics to supersonic wing design is reviewed. The first study employed a nonlinear potential flow code to design wings for high lift and low drag due to lift by employing a controlled leading-edge expansion in which the crossflow accelerates to supercritical conditions and decelerates through a weak shock. The second study utilized a modified linearized theory code to explore the concept of using 'attainable' leading-edge thrust as a guide for selecting a wing leading-edge shape (planform and radius) for maintaining attached flow and maximizing leading-edge thrust. Experimental and theoretical results obtained during the course of these two studies are discussed.

  6. A novel mechanism for emulating insect wing kinematics

    International Nuclear Information System (INIS)

    Seshadri, Pranay; Benedict, Moble; Chopra, Inderjit

    2012-01-01

    A novel dual-differential four-bar flapping mechanism that can accurately emulate insect wing kinematics in all three degrees of freedom (translation, rotation and stroke plane deviation) is developed. The mechanism is specifically designed to be simple and scalable such that it can be utilized on an insect-based flapping wing micro air vehicle. Kinematic formulations for the wing stroke position, pitch angle and coning angle for this model are derived from first principles and compared with a 3D simulation. A benchtop flapping mechanism based on this model was designed and built, which was also equipped with a balance for force measurements. 3D motion capture tests were conducted on this setup to demonstrate the capability of generating complex figure-of-eight flapping motions along with dynamic pitching. The dual-differential four-bar mechanism was implemented on a light-weight vehicle that demonstrated tethered hover. (paper)

  7. AERODYNAMIC LOAD OF AN AIRCRAFT WITH A HIGHLY ELASTIC WING

    Directory of Open Access Journals (Sweden)

    Pavel Schoř

    2017-09-01

    Full Text Available In this article, a method for calculation of air loads of an aircraft with an elastic wing is presented. The method can predict a redistribution of air loads when the elastic wing deforms. Unlike the traditional Euler or Navier-Stokes CFD to FEM coupling, the method uses 3D panel method as a source of aerodynamic data. This makes the calculation feasible on a typical recent workstation. Due to a short computational time and low hardware demands this method is suitable for both the preliminary design stage and the load evaluation stage. A case study is presented. The study compares a glider wing performing a pull maneuver at both rigid and and elastic state. The study indicates a significant redistribution of air load at the elastic case.

  8. Aeroelastic Flutter of Subsonic Aircraft Wing Section with Control Surface

    Directory of Open Access Journals (Sweden)

    Aeroelastic Flutter of Subsonic Aircraft Wing Section with Control Surface

    2015-12-01

    Full Text Available Aeroelastic flutter in aircraft mechanisms is unavoidable, essentially in the wing and control surface. In this work a three degree-of-freedom aeroelastic wing section with trailing edge flap is modeled numerically and theoretically. FLUENT code based on the steady finite volume is used for the prediction of the steady aerodynamic characteristics (lift, drag, pitching moment, velocity, and pressure distribution as well as the Duhamel formulation is used to model the aerodynamic loads theoretically. The system response (pitch, flap pitch and plunge was determined by integration the governing equations using MATLAB with a standard Runge–Kutta algorithm in conjunction with Henon’s method. The results are compared with previous experimental data. The results show that the aerodynamic loads and wing-flap system response are increased when increasing the flow speed. On the other hand the aeroelastic response led up to limit cycle oscillation when the flow equals or more than flutter speed.

  9. Surface Roughness Measurement on a Wing Aircraft by Speckle Correlation

    Directory of Open Access Journals (Sweden)

    Alberto Barrientos

    2013-09-01

    Full Text Available The study of the damage of aeronautical materials is important because it may change the microscopic surface structure profiles. The modification of geometrical surface properties can cause small instabilities and then a displacement of the boundary layer. One of the irregularities we can often find is surface roughness. Due to an increase of roughness and other effects, there may be extra momentum losses in the boundary layer and a modification in the parasite drag. In this paper we present a speckle method for measuring the surface roughness on an actual unmanned aircraft wing. The results show an inhomogeneous roughness distribution on the wing, as expected according to the anisotropic influence of the winds over the entire wing geometry. A calculation of the uncertainty of the technique is given.

  10. Surface roughness measurement on a wing aircraft by speckle correlation.

    Science.gov (United States)

    Salazar, Félix; Barrientos, Alberto

    2013-09-05

    The study of the damage of aeronautical materials is important because it may change the microscopic surface structure profiles. The modification of geometrical surface properties can cause small instabilities and then a displacement of the boundary layer. One of the irregularities we can often find is surface roughness. Due to an increase of roughness and other effects, there may be extra momentum losses in the boundary layer and a modification in the parasite drag. In this paper we present a speckle method for measuring the surface roughness on an actual unmanned aircraft wing. The results show an inhomogeneous roughness distribution on the wing, as expected according to the anisotropic influence of the winds over the entire wing geometry. A calculation of the uncertainty of the technique is given.

  11. Effects of external influences in subsonic delta wing vortices

    Science.gov (United States)

    Washburn, Anthony E.

    1992-01-01

    An experimental investigation was conducted to examine inconsistencies in reported studies for the vortical flow over highly-swept delta wings. A 76-deg swept delta wing was tested in three facilities with open and closed test sections and different model-support systems. The results obtained include surface oil-flow patterns, off-body laser-light-sheet flow visualization, and aerodynamic load measurements. Parameters such as the wall boundaries and model-support systems can drastically alter the loads. The effect of a high level of free-stream turbulence on the delta-wing flowfield was also examined and found to be significant. The increase in free-stream turbulence caused boundary-layer transition, unsteadiness in the vortex core positions, and altered the loads and moments.

  12. Shape matters: improved flight in tapered auto-rotating wings

    Science.gov (United States)

    Liu, Yucen; Vincent, Lionel; Kanso, Eva

    2017-11-01

    Many plants use gravity and wind to disperse their seeds. The shape of seed pods influence their aerodynamics. For example, Liana seeds form aerodynamic gliders and Sycamore trees release airborne ``helicopters.'' Here, we use carefully-controlled experiments and high-speed photography to examine dispersion by tumbling (auto-rotation) and we focus on the effect of geometry on flight characteristics. We consider four families of shapes: rectangular, elliptic, tapered, and sharp-tip wings, and we vary the span-to-chord ratio. We find that tapered wings exhibit extended flight time and range, that is, better performance. A quasi-steady two-dimensional model is used to highlight the mechanisms by which shape affects flight performance. These findings could have significant implications on linking seedpod designs to seed dispersion patterns as well as on optimizing wing design in active flight problems.

  13. Development and experiments of the Sea-Wing underwater glider

    Science.gov (United States)

    Yu, Jian-Cheng; Zhang, Ai-Qun; Jin, Wen-Ming; Chen, Qi; Tian, Yu; Liu, Chong-Jie

    2011-12-01

    Underwater gliders, which glide through water columns by use of a pair of wings, are efficient long-distance, long-duration marine environment observatory platforms. The Sea-Wing underwater glider, developed by the Shenyang Institute of Automation, CAS, is designed for the application of deep-sea environment variables observation. The system components, the mechanical design, and the control system design of the Sea-Wing underwater glider are described in this paper. The pitch and roll adjusting models are derived based on the mechanical design, and the adjusting capabilities for the pitch and roll are analyzed according to the models. Field experiments have been carried out for validating the gliding motion and the ability of measuring ocean environment variables. Experimental results of the motion performances of the glider are presented.

  14. HYDRODYNAMICS OF OSCILLATING WING ON THE PITCH ANGLE

    Directory of Open Access Journals (Sweden)

    Vitalii Korobov

    2017-07-01

    Full Text Available Purpose: research of the hydrodynamic characteristics of a wing in a nonstationary stream. Methods: The experimental studies of the hydrodynamic load acting on the wing of 1.5 elongation, wich harmonically oscillated respect to the transversal axis in the frequency range of 0.2-2.5 Hz. The flow speed in the hydrodynamic tunnel ranged of 0.2-1.5 m/s. Results: The instantaneous values of the coefficients of lift and drag / thrust on the pitch angle at unsteady flow depends on the Strouhal number.Discussion: with increasing oscillation frequency coefficients of hydrodynamic force components significantly higher than the data for the stationary blowing out of the wing.

  15. Spanwise drag variation on low Re wings -- revisited

    Science.gov (United States)

    Yang, Shanling; Spedding, Geoffrey

    2011-11-01

    Aerodynamic performance measurement and prediction of airfoils and wings at chord Reynolds numbers below 105 is both difficult and increasingly important in application to small-scale aircraft. Not only are the aerodynamics strongly affected by the dynamics of the unstable laminar boundary layer but the flow is decreasingly likely to be two-dimensional as Re decreases. The spanwise variation of the flow along a two-dimensional geometry is often held to be responsible for the large variations in measured profile drag coefficient. Here we measure local two-dimensional drag coefficients along a finite wing using non-intrusive PIV methods. Variations in Cd (y) can be related to local flow variations on the wing itself. Integrated values can be compared with force balance data, and the proper description of drag components at low Re will be discussed.

  16. Flow Measurements of a Plunging Wing in Unsteady Environment

    Science.gov (United States)

    Wengel, Jesse; Nathan, Rungun; Cheng, Bo; Eslam-Panah, Azar

    2017-11-01

    Despite the great progress in their design and control, Unmanned Aerial Vehicles (UAVs) are tremendously troubled while flying in turbulent environments, which are common in the lower atmospheric boundary layer (ABL). A nominally 2D plunging wing was developed and tested in the presence of unsteady wake to investigate the effect of the flow disturbances on vorticity fields. The experiments were conducted in a water channel facility with test section width of 0.76 m, and a water depth of 0.6 m. The unsteady wake in the form of von Kármán Vortex Street was generated by a cylinder located upstream of the plunging wing. The plunge amplitude and frequency of the oscillation were adjusted to bracket the range of Strouhal numbers relevant to the biological locomotion (0.25PIV) was employed to quantitatively study the effect of unsteady wake on the flow measurements of the plunging wing.

  17. Wing bone geometry reveals active flight in Archaeopteryx.

    Science.gov (United States)

    Voeten, Dennis F A E; Cubo, Jorge; de Margerie, Emmanuel; Röper, Martin; Beyrand, Vincent; Bureš, Stanislav; Tafforeau, Paul; Sanchez, Sophie

    2018-03-13

    Archaeopteryx is an iconic fossil taxon with feathered wings from the Late Jurassic of Germany that occupies a crucial position for understanding the early evolution of avian flight. After over 150 years of study, its mosaic anatomy unifying characters of both non-flying dinosaurs and flying birds has remained challenging to interpret in a locomotory context. Here, we compare new data from three Archaeopteryx specimens obtained through phase-contrast synchrotron microtomography to a representative sample of archosaurs employing a diverse array of locomotory strategies. Our analyses reveal that the architecture of Archaeopteryx's wing bones consistently exhibits a combination of cross-sectional geometric properties uniquely shared with volant birds, particularly those occasionally utilising short-distance flapping. We therefore interpret that Archaeopteryx actively employed wing flapping to take to the air through a more anterodorsally posteroventrally oriented flight stroke than used by modern birds. This unexpected outcome implies that avian powered flight must have originated before the latest Jurassic.

  18. Inference with the Median of a Prior

    Directory of Open Access Journals (Sweden)

    Ali Mohammad-Djafari

    2006-06-01

    Full Text Available We consider the problem of inference on one of the two parameters of a probability distribution when we have some prior information on a nuisance parameter. When a prior probability distribution on this nuisance parameter is given, the marginal distribution is the classical tool to account for it. If the prior distribution is not given, but we have partial knowledge such as a fixed number of moments, we can use the maximum entropy principle to assign a prior law and thus go back to the previous case. In this work, we consider the case where we only know the median of the prior and propose a new tool for this case. This new inference tool looks like a marginal distribution. It is obtained by first remarking that the marginal distribution can be considered as the mean value of the original distribution with respect to the prior probability law of the nuisance parameter, and then, by using the median in place of the mean.

  19. Design, realization and structural testing of a compliant adaptable wing

    International Nuclear Information System (INIS)

    Molinari, G; Arrieta, A F; Ermanni, P; Quack, M; Morari, M

    2015-01-01

    This paper presents the design, optimization, realization and testing of a novel wing morphing concept, based on distributed compliance structures, and actuated by piezoelectric elements. The adaptive wing features ribs with a selectively compliant inner structure, numerically optimized to achieve aerodynamically efficient shape changes while simultaneously withstanding aeroelastic loads. The static and dynamic aeroelastic behavior of the wing, and the effect of activating the actuators, is assessed by means of coupled 3D aerodynamic and structural simulations. To demonstrate the capabilities of the proposed morphing concept and optimization procedure, the wings of a model airplane are designed and manufactured according to the presented approach. The goal is to replace conventional ailerons, thus to achieve controllability in roll purely by morphing. The mechanical properties of the manufactured components are characterized experimentally, and used to create a refined and correlated finite element model. The overall stiffness, strength, and actuation capabilities are experimentally tested and successfully compared with the numerical prediction. To counteract the nonlinear hysteretic behavior of the piezoelectric actuators, a closed-loop controller is implemented, and its capability of accurately achieving the desired shape adaptation is evaluated experimentally. Using the correlated finite element model, the aeroelastic behavior of the manufactured wing is simulated, showing that the morphing concept can provide sufficient roll authority to allow controllability of the flight. The additional degrees of freedom offered by morphing can be also used to vary the plane lift coefficient, similarly to conventional flaps. The efficiency improvements offered by this technique are evaluated numerically, and compared to the performance of a rigid wing. (paper)

  20. Design of a hybrid rocket / inflatable wing UAV

    Science.gov (United States)

    Sudduth, Cory

    This paper discusses the design challenges and development of a UAV that transitions from a rocket, which allows the aircraft to reach a target altitude rapidly, and then deploys an inflatable wing from an enclosed shell in midflight to allow for loitering and surveillance. The wing deployment and transition is tested in static and dynamic environments, while the performance and stability of both the aircraft mode and rocket mode are examined analytically. An in-depth discussion of key components, including the design, analysis and testing, is also included. Designing an UAV that transitions from a high velocity rocket, to a slow velocity UAV provides many difficult and unique design challenges. For example, the incorporation of deployable wing technology into a full UAV system results in many design constraints. In this particular design inflatable wings are used to generate lift during aircraft mode, and the stabilizing fins for the main wing also acted as the fins for the vehicle during its rocket phase. This required the balancing of the two different vehicle configurations to ensure that the aircraft would be able to fly stably in both modes, and transition between them without catastrophic failure. Significant research, and testing went into the finding the best method of storing the inflatable wing, as well as finding the required inflation rate to minimize unsteady aerodynamic affects. Design work was also invested in the development of an inflation system, as it had to be highly reliable, and yet very light weight for use in this small UAV. This paper discusses how these design challenges were overcome, the development and testing of individual sub-components and how they are incorporated into the overall vehicle. The analysis that went into this UAV, as well as methods used to optimize the design in order to minimize weight and maximize the aircraft performance and loitering time is also discussed.

  1. Cabin-fuselage-wing structural design concept with engine installation

    Science.gov (United States)

    Ariotti, Scott; Garner, M.; Cepeda, A.; Vieira, J.; Bolton, D.

    1993-01-01

    The purpose of this project is to provide a fuselage structural assembly and wing structural design that will be able to withstand the given operational parameters and loads provided by Federal Aviation Regulation Part 23 (FAR 23) and the Statement of Work (SOW). The goal is to provide a durable lightweight structure that will transfer the applied loads through the most efficient load path. Areas of producibility and maintainability of the structure will also be addressed. All of the structural members will also meet or exceed the desired loading criteria, along with providing adequate stiffness, reliability, and fatigue life as stated in the SOW. Considerations need to be made for control system routing and cabin heating/ventilation. The goal of the wing structure and carry through structure is also to provide a simple, lightweight structure that will transfer the aerodynamic forces produced by the wing, tailboom, and landing gear. These forces will be channeled through various internal structures sized for the pre-determined loading criteria. Other considerations were to include space for flaps, ailerons, fuel tanks, and electrical and control system routing. The difficulties encountered in the fuselage design include expanding the fuselage cabin to accept a third occupant in a staggered configuration and providing ample volume for their safety. By adding a third person the CG of aircraft will move forward so the engine needs to be moved aft to compensate for the difference in the moment. This required the provisions of a ring frame structure for the new position of the engine mount. The difficulties encountered in the wing structural design include resizing the wing for the increased capacity and weight, and compensating for a large torsion produced by the tail boom by placing a great number of stiffeners inside the boom, which will result in the relocation of the fuel tank. Finally, an adequate carry through structure for the wing and fuselage interface will be

  2. Experimental Investigation of Pitch Control Enhancement to the Flapping Wing Micro Air Vehicle

    National Research Council Canada - National Science Library

    Kian, Chin C

    2006-01-01

    .... The MAV without the main fixed-wing is placed in a laminar flow field within a low speed wind tunnel with the wake after the flapping wings characterized with a constant temperature anemometer...

  3. The effective compliance of spatially evolving planar wing-cracks

    Science.gov (United States)

    Ayyagari, R. S.; Daphalapurkar, N. P.; Ramesh, K. T.

    2018-02-01

    We present an analytic closed form solution for anisotropic change in compliance due to the spatial evolution of planar wing-cracks in a material subjected to largely compressive loading. A fully three-dimensional anisotropic compliance tensor is defined and evaluated considering the wing-crack mechanism, using a mixed-approach based on kinematic and energetic arguments to derive the coefficients in incremental compliance. Material, kinematic and kinetic parametric influences on the increments in compliance are studied in order to understand their physical implications on material failure. Model verification is carried out through comparisons to experimental uniaxial compression results to showcase the predictive capabilities of the current study.

  4. Artificial Bird Feathers: An Adaptive Wing with High Lift Capability.

    Science.gov (United States)

    Hage, W.; Meyer, R.; Bechert, D. W.

    1997-11-01

    In Wind tunnel experiments, the operation of the covering feathers of bird wings has been investigated. At incipient flow separation, local flow reversal lifts the feathers and inhibits the spreading of the separation regime towards the leading edge. This mechanism can be utilized by movable flaps on airfoils. The operation of quasi-steady and of vibrating movable flaps is outlined. These devices are self-actuated, require no energy and do not produce parasitic drag. They are compatible with laminar and turbulent airfoils as well as with various conventional flaps on aircraft wings. Laboratory and flight experiments are shown. Ref: AIAA-Paper 97-1960.

  5. Experimental and computational study of transonic flow about swept wings

    Science.gov (United States)

    Bertelrud, A.; Bergmann, M. Y.; Coakley, T. J.

    1980-01-01

    An experimental investigation of NACA 0010 and 10% circular arc wing models, swept at 45 deg, spanning a channel, and at zero angle of attack is described. Measurements include chordwise and spanwise surface pressure distributions and oil-flow patterns for a range of transonic Mach numbers and Reynolds numbers. Calculations using a new three-dimensional Navier-Stokes code and a two-equation turbulence model are included for the circular-arc wing flow. Reasonable agreement between measurements and computations is obtained.

  6. Wake patterns of the wings and tail of hovering hummingbirds

    Science.gov (United States)

    Altshuler, Douglas L.; Princevac, Marko; Pan, Hansheng; Lozano, Jesse

    The flow fields of slowly flying bats and fasterflying birds differ in that bats produce two vortex loops during each stroke, one per wing, and birds produce a single vortex loop per stroke. In addition, the circulation at stroke transition approaches zero in bats but remains strong in birds. It is unknown if these difference derive from fundamental differences in wing morphology or are a consequence of flight speed. Here, we present an analysis of the horizontal flow field underneath hovering Anna's hummingbirds (Calypte anna) to describe the wake of a bird flying at zero forward velocity. We also consider how the hummingbird tail interacts with the wake generated by the wings. High-speed image recording and analysis from three orthogonal perspectives revealed that the wing tips reach peak velocities in the middle of each stroke and approach zero velocity at stroke transition. Hummingbirds use complex tail kinematic patterns ranging from in phase to antiphase cycling with respect to the wings, covering several phase shifted patterns. We employed particle image velocimetry to attain detailed horizontal flow measurements at three levels with respect to the tail: in the tail, at the tail tip, and just below the tail. The velocity patterns underneath the wings indicate that flow oscillates along the ventral-dorsal axis in response to the down- and up-strokes and that the sideways flows with respect to the bird are consistently from the lateral to medial. The region around the tail is dominated by axial flows in dorsal to ventral direction. We propose that these flows are generated by interaction between the wakes of the two wings at the end of the upstroke, and that the tail actively defects flows to generate moments that contribute to pitch stability. The flow fields images also revealed distinct vortex loops underneath each wing, which were generated during each stroke. From these data, we propose a model for the primary flow structures of hummingbirds that more

  7. Aerodynamic Optimization of an Over-the-Wing-Nacelle-Mount Configuration

    OpenAIRE

    Sasaki, Daisuke; Nakahashi, Kazuhiro

    2011-01-01

    An over-the-wing-nacelle-mount airplane configuration is known to prevent the noise propagation from jet engines toward ground. However, the configuration is assumed to have low aerodynamic efficiency due to the aerodynamic interference effect between a wing and a nacelle. In this paper, aerodynamic design optimization is conducted to improve aerodynamic efficiency to be equivalent to conventional under-the-wing-nacelle-mount configuration. The nacelle and wing geometry are modified to achiev...

  8. A new genus of long-legged flies displaying remarkable wing directional asymmetry.

    OpenAIRE

    Runyon, Justin B; Hurley, Richard L

    2004-01-01

    A previously unknown group of flies is described whose males exhibit directional asymmetry, in that the left wing is larger than, and of a different shape from, the right wing. To our knowledge, wing asymmetry of this degree has not previously been reported in an animal capable of flight. Such consistent asymmetry must result from a left-right axis during development, a level of differentiation whose existence has been questioned for insects. Wing asymmetry of this magnitude has implications ...

  9. Digital gene expression tag profiling of bat digits provides robust candidates contributing to wing formation

    Directory of Open Access Journals (Sweden)

    Young Rebecca L

    2010-11-01

    Full Text Available Abstract Background As the only truly flying mammals, bats use their unique wing - consisting of four elongated digits (digits II-V connected by membranes - to power their flight. In addition to the elongated digits II-V, the forelimb contains one shorter digit (digit I that is morphologically similar to the hindlimb digits. Here, we capitalized on the morphological variation among the bat forelimb digits to investigate the molecular mechanisms underlying digit elongation and wing formation. Using next generation sequencing technology, we performed digital gene expression tag profiling (DGE-tag profiling of developing digits in a pooled sample of two Myotis ricketti and validated our sequencing results using real-time quantitative PCR (RT-qPCR of gene expression in the developing digits of two Hipposideros armiger. Results Among hundreds of genes exhibiting significant differences in expression between the short and long digits, we highlight 14 genes most related to digit elongation. These genes include two Tbx genes (Tbx3 and Tbx15, five BMP pathway genes (Bmp3, RGMB, Smad1, Smad4 and Nog, four Homeobox genes (Hoxd8, Hoxd9, Hoxa1 and Satb1, and three other genes (Twist1, Tmeff2 and Enpp2 related to digit malformations or cell proliferation. In addition, our results suggest that Tbx4 and Pitx2 contribute to the morphological similarity and five genes (Acta1, Tnnc2, Atp2a1, Hrc and Myoz1 contribute to the functional similarity between the thumb and hindlimb digits. Conclusions Results of this study not only implicate many developmental genes as robust candidates underlying digit elongation and wing formation in bats, but also provide a better understanding of the genes involved in autopodial development in general.

  10. Exploring and exploiting natural variation in the wings of a predatory ladybird beetle for biological control

    NARCIS (Netherlands)

    Lommen, S.T.E.

    2013-01-01

    The central theme of this PhD thesis is natural variation in the wing length of the predatory two-spot ladybird beetle, Adalia bipunctata. ‘Wingless’ individuals of this species occur occasionally. They possess truncated wing covers and flight wings and cannot fly, but the extent of the reduction is

  11. A mechanical model of wing and theoretical estimate of taper factor ...

    Indian Academy of Sciences (India)

    PRAKASH

    β angle between humerus and body βmin minimum angle between humerus and body βe empirical span ratio (bobs/ bmax) βmin,sr minimum span ratio b wing span. bB body width bmax maximum wing span bobs observed wingspan c wing chord. Cl,max maximum lift coefficient e taper factor g acceleration due to gravity.

  12. Development and Testing of an Unconventional Morphing Wing Concept with Variable Chord and Camber

    NARCIS (Netherlands)

    Keidel, D.H.K.; Sodja, J.; Werter, N.P.M.; De Breuker, R.; Ermanni, P.; Monajjemi, M.; Liang, W.

    2015-01-01

    Driven by the need to improve the performance and energy-efficiency of aircraft, current research in the field of morphing wings is growing in significance. The most recently developed concepts typically adjust only one characteristic of the wing. Within this paper a new concept for morphing wings

  13. Power reduction and the radial limit of stall delay in revolving wings of different aspect ratio

    NARCIS (Netherlands)

    Kruyt, J.W.; Heijst, Van G.F.; Altshuler, D.L.; Lentink, David

    2015-01-01

    Airplanes and helicopters use high aspect ratio wings to reduce the power required to fly, but must operate at low angle of attack to prevent flow separation and stall. Animals capable of slow sustained flight, such as hummingbirds, have low aspect ratio wings and flap their wings at high angle

  14. Flapping wing actuation using resonant compliant mechanisms : An insect-inspired design

    NARCIS (Netherlands)

    Bolsman, C.T.

    2010-01-01

    The realization of a wing actuation mechanism for a flapping wing micro air vehicle requires a move away from traditional designs based on gears and links. An approach inspired by nature’s flyers is better suited. For flapping flight two wing motions are important: the sweeping and the pitching

  15. A predictive quasi-steady model of aerodynamic loads on flapping wings

    NARCIS (Netherlands)

    Wang, Q.; Goosen, J.F.L.; van Keulen, A.

    2016-01-01

    Quasi-steady aerodynamic models play an important role in evaluating aerodynamic performance and conducting design and optimization of flapping wings. The kinematics of flapping wings is generally a resultant motion of wing translation (yaw) and rotation (pitch and roll). Most quasi-steady models

  16. Note on the glide of a bird with wings bent downwards

    NARCIS (Netherlands)

    Sparenberg, J. A.

    This note considers the influence of the bending down of the wings of a bird on the performance of its glide. The induced drag of bent wings is compared with the induced drag of a corresponding straight wing. Numerical results are given.

  17. 78 FR 3356 - Airworthiness Directives; Various Aircraft Equipped With Wing Lift Struts

    Science.gov (United States)

    2013-01-16

    ...) of this AD, inspect the wing lift strut forks for cracks using magnetic particle procedures, such as... Airworthiness Directives; Various Aircraft Equipped With Wing Lift Struts AGENCY: Federal Aviation... existing airworthiness directive (AD) that applies to certain aircraft equipped with wing lift struts. The...

  18. Heuristics as Bayesian inference under extreme priors.

    Science.gov (United States)

    Parpart, Paula; Jones, Matt; Love, Bradley C

    2018-05-01

    Simple heuristics are often regarded as tractable decision strategies because they ignore a great deal of information in the input data. One puzzle is why heuristics can outperform full-information models, such as linear regression, which make full use of the available information. These "less-is-more" effects, in which a relatively simpler model outperforms a more complex model, are prevalent throughout cognitive science, and are frequently argued to demonstrate an inherent advantage of simplifying computation or ignoring information. In contrast, we show at the computational level (where algorithmic restrictions are set aside) that it is never optimal to discard information. Through a formal Bayesian analysis, we prove that popular heuristics, such as tallying and take-the-best, are formally equivalent to Bayesian inference under the limit of infinitely strong priors. Varying the strength of the prior yields a continuum of Bayesian models with the heuristics at one end and ordinary regression at the other. Critically, intermediate models perform better across all our simulations, suggesting that down-weighting information with the appropriate prior is preferable to entirely ignoring it. Rather than because of their simplicity, our analyses suggest heuristics perform well because they implement strong priors that approximate the actual structure of the environment. We end by considering how new heuristics could be derived by infinitely strengthening the priors of other Bayesian models. These formal results have implications for work in psychology, machine learning and economics. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Dynamic emotion perception and prior expectancy.

    Science.gov (United States)

    Dzafic, Ilvana; Martin, Andrew K; Hocking, Julia; Mowry, Bryan; Burianová, Hana

    2016-06-01

    Social interactions require the ability to rapidly perceive emotion from various incoming dynamic, multisensory cues. Prior expectations reduce incoming emotional information and direct attention to cues that are aligned with what is expected. Studies to date have investigated the prior expectancy effect using static emotional images, despite the fact that dynamic stimuli would represent greater ecological validity. The objective of the study was to create a novel functional magnetic resonance imaging (fMRI) paradigm to examine the influence of prior expectations on naturalistic emotion perception. For this purpose, we developed a dynamic emotion perception task, which consisted of audio-visual videos that carry emotional information congruent or incongruent with prior expectations. The results show that emotional congruency was associated with activity in prefrontal regions, amygdala, and putamen, whereas emotional incongruency was associated with activity in temporoparietal junction and mid-cingulate gyrus. Supported by the behavioural results, our findings suggest that prior expectations are reinforced after repeated experience and learning, whereas unexpected emotions may rely on fast change detection processes. The results from the current study are compatible with the notion that the ability to automatically detect unexpected changes in complex dynamic environments allows for adaptive behaviours in potentially advantageous or threatening situations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. PHOTOGRAMMETRIC MEASUREMENTS IN FIXED WING UAV IMAGERY

    Directory of Open Access Journals (Sweden)

    E. Gülch

    2012-07-01

    Full Text Available Several flights have been undertaken with PAMS (Photogrammetric Aerial Mapping System by Germap, Germany, which is briefly introduced. This system is based on the SmartPlane fixed-wing UAV and a CANON IXUS camera system. The plane is equipped with GPS and has an infrared sensor system to estimate attitude values. A software has been developed to link the PAMS output to a standard photogrammetric processing chain built on Trimble INPHO. The linking of the image files and image IDs and the handling of different cases with partly corrupted output have to be solved to generate an INPHO project file. Based on this project file the software packages MATCH-AT, MATCH-T DSM, OrthoMaster and OrthoVista for digital aerial triangulation, DTM/DSM generation and finally digital orthomosaik generation are applied. The focus has been on investigations on how to adapt the "usual" parameters for the digital aerial triangulation and other software to the UAV flight conditions, which are showing high overlaps, large kappa angles and a certain image blur in case of turbulences. It was found, that the selected parameter setup shows a quite stable behaviour and can be applied to other flights. A comparison is made to results from other open source multi-ray matching software to handle the issue of the described flight conditions. Flights over the same area at different times have been compared to each other. The major objective was here to see, on how far differences occur relative to each other, without having access to ground control data, which would have a potential for applications with low requirements on the absolute accuracy. The results show, that there are influences of weather and illumination visible. The "unusual" flight pattern, which shows big time differences for neighbouring strips has an influence on the AT and DTM/DSM generation. The results obtained so far do indicate problems in the stability of the camera calibration. This clearly requests a

  1. Study on flow over finite wing with respect to F-22 raptor, Supermarine Spitfire, F-7 BG aircraft wing and analyze its stability performance and experimental values

    Science.gov (United States)

    Ali, Md. Nesar; Alam, Mahbubul

    2017-06-01

    A finite wing is a three-dimensional body, and consequently the flow over the finite wing is three-dimensional; that is, there is a component of flow in the span wise direction. The physical mechanism for generating lift on the wing is the existence of a high pressure on the bottom surface and a low pressure on the top surface. The net imbalance of the pressure distribution creates the lift. As a by-product of this pressure imbalance, the flow near the wing tips tends to curl around the tips, being forced from the high-pressure region just underneath the tips to the low-pressure region on top. This flow around the wing tips is shown in the front view of the wing. As a result, on the top surface of the wing, there is generally a span wise component of flow from the tip toward the wing root, causing the streamlines over the top surface to bend toward the root. On the bottom surface of the wing, there is generally a span wise component of flow from the root toward the tip, causing the streamlines over the bottom surface to bend toward the tip. Clearly, the flow over the finite wing is three-dimensional, and therefore we would expect the overall aerodynamic properties of such a wing to differ from those of its airfoil sections. The tendency for the flow to "leak" around the wing tips has another important effect on the aerodynamics of the wing. This flow establishes a circulatory motion that trails downstream of the wing; that is, a trailing vortex is created at each wing tip. The aerodynamics of finite wings is analyzed using the classical lifting line model. This simple model allows a closed-form solution that captures most of the physical effects applicable to finite wings. The model is based on the horseshoe-shaped vortex that introduces the concept of a vortex wake and wing tip vortices. The downwash induced by the wake creates an induced drag that did not exist in the two-dimensional analysis. Furthermore, as wingspan is reduced, the wing lift slope decreases

  2. Aerodynamic performance and particle image velocimetery of piezo actuated biomimetic manduca sexta engineered wings towards the design and application of a flapping wing flight vehicle

    Science.gov (United States)

    DeLuca, Anthony M.

    Considerable research and investigation has been conducted on the aerodynamic performance, and the predominate flow physics of the Manduca Sexta size of biomimetically designed and fabricated wings as part of the AFIT FWMAV design project. Despite a burgeoning interest and research into the diverse field of flapping wing flight and biomimicry, the aerodynamics of flapping wing flight remains a nebulous field of science with considerable variance into the theoretical abstractions surrounding aerodynamic mechanisms responsible for aerial performance. Traditional FWMAV flight models assume a form of a quasi-steady approximation of wing aerodynamics based on an infinite wing blade element model (BEM). An accurate estimation of the lift, drag, and side force coefficients is a critical component of autonomous stability and control models. This research focused on two separate experimental avenues into the aerodynamics of AFIT's engineered hawkmoth wings|forces and flow visualization. 1. Six degree of freedom force balance testing, and high speed video analysis was conducted on 30°, 45°, and 60° angle stop wings. A novel, non-intrusive optical tracking algorithm was developed utilizing a combination of a Gaussian Mixture Model (GMM) and ComputerVision (OpenCV) tools to track the wing in motion from multiple cameras. A complete mapping of the wing's kinematic angles as a function of driving amplitude was performed. The stroke angle, elevation angle, and angle of attack were tabulated for all three wings at driving amplitudes ranging from A=0.3 to A=0.6. The wing kinematics together with the force balance data was used to develop several aerodynamic force coefficient models. A combined translational and rotational aerodynamic model predicted lift forces within 10%, and vertical forces within 6%. The total power consumption was calculated for each of the three wings, and a Figure of Merit was calculated for each wing as a general expression of the overall efficiency of

  3. Effect of wing planform and canard location and geometry on the longitudinal aerodynamic characteristics of a close-coupled canard wing model at subsonic speeds

    Science.gov (United States)

    Gloss, B. B.

    1975-01-01

    A generalized wind-tunnel model with canard and wing planforms typical of highly maneuverable aircraft was tested in the Langley 7- by 10-foot high-speed tunnel at a Mach number of 0.30 to determine the effect of canard location, canard size, wing sweep, and canard strake on canard-wing interference to high angles of attack. The major results of this investigation may be summarized as follows: the high-canard configuration (excluding the canard strake and canard flap), for both the 60 deg and 44 deg swept leading-edge wings, produced the highest maximum lift coefficient and the most linear pitching-moment curves; substantially larger gains in the canard lift and total lift were obtained by adding a strake to the canard located below the wing chord plane rather than by adding a strake to the canard located above the wing chord plane.

  4. Multidimensional analysis of Drosophila wing variation in Evolution ...

    Indian Academy of Sciences (India)

    In this study, using Drosophila melanogaster isofemale lines derived from wild flies collected on both slopes of the canyon, we investigated the effect of developmental temperature upon the different components of phenotypic variation of a complex trait: the wing. Combining geometric and traditional morphometrics, we find ...

  5. Investigating Biological Controls to Suppress Spotted Wing Drosophila Populations

    Science.gov (United States)

    The spotted wing drosophila has become a major cherry pest in California. To develop sustainable management options for this highly mobile pest, we worked with cooperators at Oregon State University and the USDA to discover and import natural enemies of the fly from its native range in South Korea ...

  6. Monitoring of a Full-Scale Wing Fatigue Test

    NARCIS (Netherlands)

    Heida, Jaap; Hwang, Joong Sun

    2014-01-01

    A wing of a decommissioned aircraft of the Royal Netherlands Air Force (RNLAF) was fatigue tested to more than two times the design life. Part of the test was the evaluation of load monitoring and Structural Health Monitoring (SHM) techniques. For load monitoring the data of conventional resistance

  7. Electric Propulsion Concepts for an Inverted Joined Wing Airplane Demonstrator

    Directory of Open Access Journals (Sweden)

    Cezary Galinski

    2017-05-01

    Full Text Available One of the airplane design concepts that potentially allows for significantly increased efficiency, but has not yet been investigated thoroughly, is the inverted joined wing configuration, where the upper wing is positioned in front of the lower one. We performed wind tunnel and flight testing of a demonstrator of this concept, first by applying electrical propulsion to simplify wind tunnel testing, and then the same electrical-propulsion demonstrator performed several flights. As the chosen propulsion method proved to be too cumbersome for an intensive flight campaign and significant loss of battery performance was also observed, the electrical propulsion was then replaced by internal combustion propulsion in the second phase, involving longer-duration flight testing. Next we identified and analyzed two potentially beneficial modifications to the design tested: one involved shifting the center of gravity towards the aft, the other involved modifying the thrust vector position, both with the assumption that electric motors can be applied for propulsion. On this basis, the paper finishes with some conclusions concerning a new concept of electrical propulsion for an inverted joined wing design, combining two ideas: hybridization and distribution along the aft wing leading edge.

  8. Modeling Aircraft Wing Loads from Flight Data Using Neural Networks

    Science.gov (United States)

    Allen, Michael J.; Dibley, Ryan P.

    2003-01-01

    Neural networks were used to model wing bending-moment loads, torsion loads, and control surface hinge-moments of the Active Aeroelastic Wing (AAW) aircraft. Accurate loads models are required for the development of control laws designed to increase roll performance through wing twist while not exceeding load limits. Inputs to the model include aircraft rates, accelerations, and control surface positions. Neural networks were chosen to model aircraft loads because they can account for uncharacterized nonlinear effects while retaining the capability to generalize. The accuracy of the neural network models was improved by first developing linear loads models to use as starting points for network training. Neural networks were then trained with flight data for rolls, loaded reversals, wind-up-turns, and individual control surface doublets for load excitation. Generalization was improved by using gain weighting and early stopping. Results are presented for neural network loads models of four wing loads and four control surface hinge moments at Mach 0.90 and an altitude of 15,000 ft. An average model prediction error reduction of 18.6 percent was calculated for the neural network models when compared to the linear models. This paper documents the input data conditioning, input parameter selection, structure, training, and validation of the neural network models.

  9. Wings of the Night: The Natural History of Bats

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 11. Wings of the Night: The Natural History of Bats. Uttam Saikia. General Article Volume 12 Issue 11 November 2007 pp 63-76. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/012/11/0063-0076 ...

  10. Robust Backstepping Control of Wing Rock Using Disturbance Observer

    Directory of Open Access Journals (Sweden)

    Dawei Wu

    2017-02-01

    Full Text Available Wing rock is a highly nonlinear phenomenon when the aircraft suffers undesired roll-dominated oscillatory at high angle of attack (AOA. Considering the strong nonlinear and unsteady aerodynamic characteristics, an uncertain multi-input and multi-output (MIMO nonlinear wing rock model is studied, and system uncertainties, unsteady aerodynamic disturbances and externaldisturbancesareconsideredinthedesignofwingrockcontrollaw. Tohandletheproblemof multipledisturbances,arobustcontrolschemeisproposedbasedontheextendedstateobserver(ESO and the radial basis function neural network (RBFNN technique. Considering that the effectiveness of actuators are greatly decreased at high AOA, the input saturation problem is also handled by constructing a corresponding auxiliary system. Based on the improved ESO and the auxiliary system, a robust backstepping control law is proposed for the wing rock control. In addition, the dynamic surface control (DSC technique is introduced to avoid the tedious computations of time derivatives for the virtual control laws in the backstepping method. The stability of the closed-loop system is guaranteed via rigorously Lyapunov analysis. Finally, simulation results are presented to illustrate the effectiveness of the ESO and the proposed wing rock control approach.

  11. Male secondary sexual characters in Aphnaeinae wings (Lepidoptera: Lycaenidae)

    OpenAIRE

    Bálint, Zsolt; Heath, Alan; Katona, Gergely; Kertész, Krisztián; Sáfián, Szabolcs

    2017-01-01

    Male secondary sexual characters have been discovered on the hindwing verso of genera Aphnaeus Hübner, [1819], Cigaritis Donzel, 1847, Lipaphnaeus Aurivillius, 1916 and Pseudaletis Druce, 1888 representing the Palaeotropical subfamily Aphnaeinae Lycaenidae: Lepidoptera). Relevant wing parts are illustrated, described, and some observations on the organs are briefly annotated. With an appendix and 14 figures.

  12. Dynamic control of a bistable wing under aerodynamic loading

    International Nuclear Information System (INIS)

    Bilgen, Onur; Arrieta, Andres F; Friswell, Michael I; Hagedorn, Peter

    2013-01-01

    The aerodynamic evaluation of a dynamic control technique applied to a bistable unsymmetrical cross-ply composite plate with surface bonded piezoelectric actuators is presented. The plate is clamped on one end to form a low-aspect-ratio wing. A previously proposed dynamic control method, utilizing bending resonance in different stable equilibrium positions, is used to induce snap-through between the two equilibrium states. Compared to quasi-static actuation, driving the bistable plate near resonance using surface bonded piezoelectric materials requires, theoretically, a lower peak excitation voltage to achieve snap-through. First, a set of extensive wind tunnel experiments are conducted on the passive bistable wing to understand the change in the dynamic behavior under various aerodynamic conditions. The passive wing demonstrated sufficient bending stiffness to sustain its shape under aerodynamic loading while preserving the desired bistable behavior. Next, by the use of the resonant control technique, the plate is turned into an effectively monostable structure, or alternatively, both stable equilibrium positions can be reached actively from the other stable equilibrium. Dynamic forward and reverse snap-through is demonstrated in the wind tunnel which shows both the effectiveness of the piezoelectric actuation as well as the load carrying capability of both states of the bistable wing. (paper)

  13. Aeroelastic Modelling and Design of Aeroelastically Tailored and Morphing Wings

    NARCIS (Netherlands)

    Werter, N.P.M.

    2017-01-01

    In order to accommodate the growth in air traffic whilst reducing the impact on the environment, operational efficiency is becoming more and more important in the design of the aircraft of the future. A possible approach to increase the operational efficiency of aircraft wings is the use of

  14. Rotational accelerations stabilize leading edge vortices on revolving fly wings

    NARCIS (Netherlands)

    Lentink, D.; Dickinson, M.H.

    2009-01-01

    The aerodynamic performance of hovering insects is largely explained by the presence of a stably attached leading edge vortex (LEV) on top of their wings. Although LEVs have been visualized on real, physically modeled, and simulated insects, the physical mechanisms responsible for their stability

  15. The marginal band system in nymphalid butterfly wings.

    Science.gov (United States)

    Taira, Wataru; Kinjo, Seira; Otaki, Joji M

    2015-01-01

    Butterfly wing color patterns are highly complex and diverse, but they are believed to be derived from the nymphalid groundplan, which is composed of several color pattern systems. Among these pattern systems, the marginal band system, including marginal and submarginal bands, has rarely been studied. Here, we examined the color pattern diversity of the marginal band system among nymphalid butterflies. Marginal and submarginal bands are usually expressed as a pair of linear bands aligned with the wing margin. However, a submarginal band can be expressed as a broken band, an elongated oval, or a single dot. The marginal focus, usually a white dot at the middle of a wing compartment along the wing edge, corresponds to the pupal edge spot, one of the pupal cuticle spots that signify the locations of color pattern organizing centers. A marginal band can be expressed as a semicircle, an elongated oval, or a pair of eyespot-like structures, which suggest the organizing activity of the marginal focus. Physical damage at the pupal edge spot leads to distal dislocation of the submarginal band in Junonia almana and in Vanessa indica, suggesting that the marginal focus functions as an organizing center for the marginal band system. Taken together, we conclude that the marginal band system is developmentally equivalent to other symmetry systems. Additionally, the marginal band is likely a core element and the submarginal band a paracore element of the marginal band system, and both bands are primarily specified by the marginal focus organizing center.

  16. Effect of Winged Subsoiler and Traditional Tillage Integrated with ...

    African Journals Online (AJOL)

    Effect of Winged Subsoiler and Traditional Tillage Integrated with Fanya Juu on Selected Soil Physico-Chemical and Soil Water Properties in the Northwestern ... Soil evaporation was estimated by a conceptual model whereby leaf area index, canopy cover, crop root length, moisture at saturation and field capacity were ...

  17. 14 CFR 23.201 - Wings level stall.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Wings level stall. 23.201 Section 23.201 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS.... Starting from a speed at least 10 knots above the stall speed, the elevator control must be pulled back so...

  18. Consequences of outbreeding on phenotypic plasticity in Drosophila mercatorum wings

    DEFF Research Database (Denmark)

    Krag, Kristian; Thomsen, Hans Paarup; Faurby, Søren

    2009-01-01

    for the wing shape. For all the other treatments higher DI was found in the F1 when the difference was significant, which is suggestive of outbreeding depression. These findings are difficult to interpret since an apparent heterotic effect of size at 25°C is accompanied by higher DI (though not significant...

  19. Calculation of Airloads for a Flexible Wing via NASTRAN.

    Science.gov (United States)

    1980-12-01

    IV. C oiiutiuULtiozial 1rcdu’.......... . .. .. . ..... interfaced NASTRAN -USSAERO Sequence .... 9 The DMAP Sequence.................11...not considered. A new instruction sequence known as a Direct Matrix Abstraction Program ( DMAP ) was developed for use within NASTRAN to ualculate...since the inclusion of aerodynamic theories in the NASTRAN program. The calculation of flexible wing airloads by this DMAP sequence is an iterative

  20. Flight mechanics of a tailless articulated wing aircraft.

    Science.gov (United States)

    Paranjape, Aditya A; Chung, Soon-Jo; Selig, Michael S

    2011-06-01

    This paper investigates the flight mechanics of a micro aerial vehicle without a vertical tail in an effort to reverse-engineer the agility of avian flight. The key to stability and control of such a tailless aircraft lies in the ability to control the incidence angles and dihedral angles of both wings independently. The dihedral angles can be varied symmetrically on both wings to control aircraft speed independently of the angle of attack and flight path angle, while asymmetric dihedral can be used to control yaw in the absence of a vertical stabilizer. It is shown that wing dihedral angles alone can effectively regulate sideslip during rapid turns and generate a wide range of equilibrium turn rates while maintaining a constant flight speed and regulating sideslip. Numerical continuation and bifurcation analysis are used to compute trim states and assess their stability. This paper lays the foundation for design and stability analysis of a flapping wing aircraft that can switch rapidly from flapping to gliding flight for agile manoeuvring in a constrained environment.

  1. Model identification of a flapping wing micro aerial vehicle

    NARCIS (Netherlands)

    Aguiar Vieira Caetano, J.V.

    2016-01-01

    Different flapping wing micro aerial vehicles (FWMAV) have been developed for academic (Harvard’s RoboBee), military (Israel Aerospace Industries’ Butterfly) and technology demonstration (Aerovironment’s NanoHummingBird) purposes. Among these, theDelFly II is recognized as one of themost successful

  2. Male secondary sexu al characters in Aphnaeinae wings (Lepidoptera: Lycaenidae

    Directory of Open Access Journals (Sweden)

    Bálint, Zsolt

    2017-04-01

    Full Text Available Male secondary sexual characters have been discovered on the hindwing verso of genera Aphnaeus Hübner, [1819], Cigaritis Donzel, 1847, Lipaphnaeus Aurivillius, 1916 and Pseudaletis Druce, 1888 representing the Palaeotropical subfamily Aphnaeinae Lycaenidae: Lepidoptera. Relevant wing parts are illustrated, described, and some observations on the organs are briefly annotated. With an appendix and 14 figures.

  3. Media coverage of right-wing populist leaders

    NARCIS (Netherlands)

    Bos, L.; van der Brug, W.; de Vreese, C.

    2010-01-01

    This article focuses on how leaders of new right-wing populist parties are portrayed in the mass media. More so than their established counterparts, new parties depend on the media for their electoral breakthrough. From a theoretical perspective, we expect prominence, populism, and authoritativeness

  4. Flow cytometry determination of ploidy level in winged bean ...

    African Journals Online (AJOL)

    Ploidy determination and mutation breeding of crop plants are inseparable twins given that mutation breeding is hinged majorly on polyploidization of crop's chromosome number. The present research was aimed at determining the ploidy level of 20 accessions of winged bean (Psophoscarpus tetragonolobus) using known ...

  5. A single basis for developmental buffering of Drosophila wing shape.

    Directory of Open Access Journals (Sweden)

    Casper J Breuker

    2006-12-01

    Full Text Available The nature of developmental buffering processes has been debated extensively, based on both theoretical reasoning and empirical studies. In particular, controversy has focused on the question of whether distinct processes are responsible for canalization, the buffering against environmental or genetic variation, and for developmental stability, the buffering against random variation intrinsic in developmental processes. Here, we address this question for the size and shape of Drosophila melanogaster wings in an experimental design with extensively replicated and fully controlled genotypes. The amounts of variation among individuals and of fluctuating asymmetry differ markedly among genotypes, demonstrating a clear genetic basis for size and shape variability. For wing shape, there is a high correlation between the amounts of variation among individuals and fluctuating asymmetry, which indicates a correspondence between the two types of buffering. Likewise, the multivariate patterns of shape variation among individuals and of fluctuating asymmetry show a close association. For wing size, however, the amounts of individual variation and fluctuating asymmetry are not correlated. There was a significant link between the amounts of variation between wing size and shape, more so for fluctuating asymmetry than for variation among individuals. Overall, these experiments indicate a considerable degree of shared control of individual variation and fluctuating asymmetry, although it appears to differ between traits.

  6. Reinforcements in avian wing bones: Experiments, analysis, and modeling.

    Science.gov (United States)

    Novitskaya, E; Ruestes, C J; Porter, M M; Lubarda, V A; Meyers, M A; McKittrick, J

    2017-12-01

    Almost all species of modern birds are capable of flight; the mechanical competency of their wings and the rigidity of their skeletal system evolved to enable this outstanding feat. One of the most interesting examples of structural adaptation in birds is the internal structure of their wing bones. In flying birds, bones need to be sufficiently strong and stiff to withstand forces during takeoff, flight, and landing, with a minimum of weight. The cross-sectional morphology and presence of reinforcing structures (struts and ridges) found within bird wing bones vary from species to species, depending on how the wings are utilized. It is shown that both morphology and internal features increases the resistance to flexure and torsion with a minimum weight penalty. Prototypes of reinforcing struts fabricated by 3D printing were tested in diametral compression and torsion to validate the concept. In compression, the ovalization decreased through the insertion of struts, while they had no effect on torsional resistance. An elastic model of a circular ring reinforced by horizontal and vertical struts is developed to explain the compressive stiffening response of the ring caused by differently oriented struts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Sensory biology: echolocation from click to call, mouth to wing.

    Science.gov (United States)

    Fenton, M Brock; Ratcliffe, John M

    2014-12-15

    Echolocators use echoes of sounds they produce, clicks or calls, to detect objects. Usually, these signals originate from the head. New work reveals that three species of bats use their wings to generate echolocation signals. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Experimental investigation into the feasibility of an extruded wing

    Science.gov (United States)

    Morelli, P.; Romeo, G.

    1979-01-01

    Fabrications of extruded aluminum alloy structures are reviewed. The design criteria and the fabrication of the main structure of a sailplane wing made of a few extruded profiles longitudinally connected one to the other are illustrated. Structural tests recently carried out are reported upon.

  9. Flight in slow motion: aerodynamics of the pterosaur wing.

    Science.gov (United States)

    Palmer, Colin

    2011-06-22

    The flight of pterosaurs and the extreme sizes of some taxa have long perplexed evolutionary biologists. Past reconstructions of flight capability were handicapped by the available aerodynamic data, which was unrepresentative of possible pterosaur wing profiles. I report wind tunnel tests on a range of possible pterosaur wing sections and quantify the likely performance for the first time. These sections have substantially higher profile drag and maximum lift coefficients than those assumed before, suggesting that large pterosaurs were aerodynamically less efficient and could fly more slowly than previously estimated. In order to achieve higher efficiency, the wing bones must be faired, which implies extensive regions of pneumatized tissue. Whether faired or not, the pterosaur wings were adapted to low-speed flight, unsuited to marine style dynamic soaring but adapted for thermal/slope soaring and controlled, low-speed landing. Because their thin-walled bones were susceptible to impact damage, slow flight would have helped to avoid injury and may have contributed to their attaining much larger sizes than fossil or extant birds. The trade-off would have been an extreme vulnerability to strong or turbulent winds both in flight and on the ground, akin to modern-day paragliders.

  10. Playback interference of glassy-winged sharp shooter communication

    Science.gov (United States)

    Animal communication is vital to reproduction, particularly for securing a mate. Insects commonly communicate by exchanging vibrational signals that are transmitted through host plants. The glassy-winged sharpshooter (GWSS), Homalodisca vitripennis, is an important vector of Xylella fastidiosa, a pl...

  11. Velocity and turbulence at a wing-wall abutment

    Indian Academy of Sciences (India)

    Experimental investigation of the 3D turbulent flow field around a 45° wing-wall abutment, resting on a rough rigid bed, is reported. The experiment was conducted ... The shear stresses acting on the bed around the abutment are estimated from the Reynolds stresses and velocity gradients. The data presented in this study ...

  12. Surfzone monitoring using rotary wing unmanned aerial vehicles

    NARCIS (Netherlands)

    Brouwer, R.L.; De Schipper, M.A.; Rynne, P.F.; Graham, F.J.; Reniers, A.J.H.M.; Macmahan, J.H.

    2015-01-01

    This study investigates the potential of rotary wing unmanned aerial vehicles (UAVs) to monitor the surfzone. This paper shows that these UAVs are extremely flexible surveying platforms that can gather nearcontinuous moderate spatial resolution and high temporal resolution imagery from a fixed

  13. The costae presenting in high-temperature-induced vestigial wings ...

    Indian Academy of Sciences (India)

    Judging by the costae presenting in the anterior wing margin, I propose that the proximal and distal costal sections are independent growth units. ... The distal costal section seems to be an extension of the radius vein. vestigial, one of the most intensely researched temperature-sensitive mutations, is a good candidate for ...

  14. Innovative Wing Structures for Improved Aerodynamic and Aeroelastic Performance

    Science.gov (United States)

    2016-06-09

    directions in the printer. The colour represent the volume of defects found by VG Studio Max holes/defects detection tool. 5.3 Conclusions on material... visual inspection of the skin surface of the different wings was performed to assess any noticeable differences. Skin surface finish is paramount for

  15. Interactive flutter analysis and parametric study for conceptual wing design

    Science.gov (United States)

    Mukhopadhyay, Vivek

    1995-01-01

    An interactive computer program was developed for wing flutter analysis in the conceptual design stage. The objective was to estimate the flutter instability boundary of a flexible cantilever wing, when well defined structural and aerodynamic data are not available, and then study the effect of change in Mach number, dynamic pressure, torsional frequency, sweep, mass ratio, aspect ratio, taper ratio, center of gravity, and pitch inertia, to guide the development of the concept. The software was developed on MathCad (trademark) platform for Macintosh, with integrated documentation, graphics, database and symbolic mathematics. The analysis method was based on nondimensional parametric plots of two primary flutter parameters, namely Regier number and Flutter number, with normalization factors based on torsional stiffness, sweep, mass ratio, aspect ratio, center of gravity location and pitch inertia radius of gyration. The plots were compiled in a Vaught Corporation report from a vast database of past experiments and wind tunnel tests. The computer program was utilized for flutter analysis of the outer wing of a Blended Wing Body concept, proposed by McDonnell Douglas Corporation. Using a set of assumed data, preliminary flutter boundary and flutter dynamic pressure variation with altitude, Mach number and torsional stiffness were determined.

  16. Velocity and turbulence at a wing-wall abutment

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    When a wing-wall abutment is placed vertically on a rigid-bed rectangular channel by attach- ing it to one of the vertical sidewalls of the channel, the approaching turbulent boundary layer undergoes separation and rolles up to form the well-known primary vortex, which swept out by the side of the abutment. Limited research ...

  17. Wing shape variation associated with mimicry in butterflies.

    Science.gov (United States)

    Jones, Robert T; Le Poul, Yann; Whibley, Annabel C; Mérot, Claire; ffrench-Constant, Richard H; Joron, Mathieu

    2013-08-01

    Mimetic resemblance in unpalatable butterflies has been studied by evolutionary biologists for over a century, but has largely focused on the convergence in wing color patterns. In Heliconius numata, discrete color-pattern morphs closely resemble comimics in the distantly related genus Melinaea. We examine the possibility that the shape of the butterfly wing also shows adaptive convergence. First, simple measures of forewing dimensions were taken of individuals in a cross between H. numata morphs, and showed quantitative differences between two of the segregating morphs, f. elegans and f. silvana. Second, landmark-based geometric morphometric and elliptical Fourier outline analyses were used to more fully characterize these shape differences. Extension of these techniques to specimens from natural populations suggested that, although many of the coexisting morphs could not be discriminated by shape, the differences we identified between f. elegans and f. silvana hold in the wild. Interestingly, despite extensive overlap, the shape variation between these two morphs is paralleled in their respective Melinaea comimics. Our study therefore suggests that wing-shape variation is associated with mimetic resemblance, and raises the intriguing possibility that the supergene responsible for controlling the major switch in color pattern between morphs also contributes to wing shape differences in H. numata. © 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.

  18. Numbers and prior knowledge in sentence comprehension

    Directory of Open Access Journals (Sweden)

    Pedro Macizo

    2013-01-01

    Full Text Available We evaluated whether the comprehension of sentences that contained numerical information could benefit from presenting numbers in Arabic format and from using prior knowledge. Participants read sentences including numbers (Arabic digits or number words while the comprehension accuracy was evaluated. In addition, the sentences were biased or unbiased by people's prior knowledge about quantities. The results showed better comprehension for sentences that contained Arabic digits as compared to number words. Moreover, biased sentences were understood more accurately than unbiased sentences. These results indicate that information about magnitude in sentence context is comprehended better when quantities are presented in Arabic format and when they are associated with participants' world knowledge.

  19. Can natural selection encode Bayesian priors?

    Science.gov (United States)

    Ramírez, Juan Camilo; Marshall, James A R

    2017-08-07

    The evolutionary success of many organisms depends on their ability to make decisions based on estimates of the state of their environment (e.g., predation risk) from uncertain information. These decision problems have optimal solutions and individuals in nature are expected to evolve the behavioural mechanisms to make decisions as if using the optimal solutions. Bayesian inference is the optimal method to produce estimates from uncertain data, thus natural selection is expected to favour individuals with the behavioural mechanisms to make decisions as if they were computing Bayesian estimates in typically-experienced environments, although this does not necessarily imply that favoured decision-makers do perform Bayesian computations exactly. Each individual should evolve to behave as if updating a prior estimate of the unknown environment variable to a posterior estimate as it collects evidence. The prior estimate represents the decision-maker's default belief regarding the environment variable, i.e., the individual's default 'worldview' of the environment. This default belief has been hypothesised to be shaped by natural selection and represent the environment experienced by the individual's ancestors. We present an evolutionary model to explore how accurately Bayesian prior estimates can be encoded genetically and shaped by natural selection when decision-makers learn from uncertain information. The model simulates the evolution of a population of individuals that are required to estimate the probability of an event. Every individual has a prior estimate of this probability and collects noisy cues from the environment in order to update its prior belief to a Bayesian posterior estimate with the evidence gained. The prior is inherited and passed on to offspring. Fitness increases with the accuracy of the posterior estimates produced. Simulations show that prior estimates become accurate over evolutionary time. In addition to these 'Bayesian' individuals, we also

  20. Genome position specific priors for genomic prediction

    DEFF Research Database (Denmark)

    Brøndum, Rasmus Froberg; Su, Guosheng; Lund, Mogens Sandø

    2012-01-01

    to estimate SNP effects, except in the case of fat yield. The small size of the Jersey validation set meant that these improvements in accuracy were not significant using a Hotelling-Williams t-test at the 5% level. An increase in accuracy of 1-2% for all traits was observed in the Australian Holstein...... population when using a prior derived from the Nordic Holstein population compared to using no prior information. These improvements were significant (PHotelling Williams t-test for protein- and fat yield Conclusion For some traits the method might be advantageous compared to pooling...

  1. A bio-inspired study on tidal energy extraction with flexible flapping wings.

    Science.gov (United States)

    Liu, Wendi; Xiao, Qing; Cheng, Fai

    2013-09-01

    Previous research on the flexible structure of flapping wings has shown an improved propulsion performance in comparison to rigid wings. However, not much is known about this function in terms of power efficiency modification for flapping wing energy devices. In order to study the role of the flexible wing deformation in the hydrodynamics of flapping wing energy devices, we computationally model the two-dimensional flexible single and twin flapping wings in operation under the energy extraction conditions with a large Reynolds number of 106. The flexible motion for the present study is predetermined based on a priori structural result which is different from a passive flexibility solution. Four different models are investigated with additional potential local distortions near the leading and trailing edges. Our simulation results show that the flexible structure of a wing is beneficial to enhance power efficiency by increasing the peaks of lift force over a flapping cycle, and tuning the phase shift between force and velocity to a favourable trend. Moreover, the impact of wing flexibility on efficiency is more profound at a low nominal effective angle of attack (AoA). At a typical flapping frequency f * = 0.15 and nominal effective AoA of 10°, a flexible integrated wing generates 7.68% higher efficiency than a rigid wing. An even higher increase, around six times that of a rigid wing, is achievable if the nominal effective AoA is reduced to zero degrees at feathering condition. This is very attractive for a semi-actuated flapping energy system, where energy input is needed to activate the pitching motion. The results from our dual-wing study found that a parallel twin-wing device can produce more power compared to a single wing due to the strong flow interaction between the two wings.

  2. Power reduction and the radial limit of stall delay in revolving wings of different aspect ratio.

    Science.gov (United States)

    Kruyt, Jan W; van Heijst, GertJan F; Altshuler, Douglas L; Lentink, David

    2015-04-06

    Airplanes and helicopters use high aspect ratio wings to reduce the power required to fly, but must operate at low angle of attack to prevent flow separation and stall. Animals capable of slow sustained flight, such as hummingbirds, have low aspect ratio wings and flap their wings at high angle of attack without stalling. Instead, they generate an attached vortex along the leading edge of the wing that elevates lift. Previous studies have demonstrated that this vortex and high lift can be reproduced by revolving the animal wing at the same angle of attack. How do flapping and revolving animal wings delay stall and reduce power? It has been hypothesized that stall delay derives from having a short radial distance between the shoulder joint and wing tip, measured in chord lengths. This non-dimensional measure of wing length represents the relative magnitude of inertial forces versus rotational accelerations operating in the boundary layer of revolving and flapping wings. Here we show for a suite of aspect ratios, which represent both animal and aircraft wings, that the attachment of the leading edge vortex on a revolving wing is determined by wing aspect ratio, defined with respect to the centre of revolution. At high angle of attack, the vortex remains attached when the local radius is shorter than four chord lengths and separates outboard on higher aspect ratio wings. This radial stall limit explains why revolving high aspect ratio wings (of helicopters) require less power compared with low aspect ratio wings (of hummingbirds) at low angle of attack and vice versa at high angle of attack. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  3. Petiolate wings: effects on the leading-edge vortex in flapping flight.

    Science.gov (United States)

    Phillips, Nathan; Knowles, Kevin; Bomphrey, Richard J

    2017-02-06

    The wings of many insect species including crane flies and damselflies are petiolate (on stalks), with the wing planform beginning some distance away from the wing hinge, rather than at the hinge. The aerodynamic impact of flapping petiolate wings is relatively unknown, particularly on the formation of the lift-augmenting leading-edge vortex (LEV): a key flow structure exploited by many insects, birds and bats to enhance their lift coefficient. We investigated the aerodynamic implications of petiolation P using particle image velocimetry flow field measurements on an array of rectangular wings of aspect ratio 3 and petiolation values of P = 1-3. The wings were driven using a mechanical device, the 'Flapperatus', to produce highly repeatable insect-like kinematics. The wings maintained a constant Reynolds number of 1400 and dimensionless stroke amplitude Λ * (number of chords traversed by the wingtip) of 6.5 across all test cases. Our results showed that for more petiolate wings the LEV is generally larger, stronger in circulation, and covers a greater area of the wing surface, particularly at the mid-span and inboard locations early in the wing stroke cycle. In each case, the LEV was initially arch-like in form with its outboard end terminating in a focus-sink on the wing surface, before transitioning to become continuous with the tip vortex thereafter. In the second half of the wing stroke, more petiolate wings exhibit a more detached LEV, with detachment initiating at approximately 70% and 50% span for P = 1 and 3, respectively. As a consequence, lift coefficients based on the LEV are higher in the first half of the wing stroke for petiolate wings, but more comparable in the second half. Time-averaged LEV lift coefficients show a general rise with petiolation over the range tested.

  4. Wing shape allometry and aerodynamics in calopterygid damselflies: a comparative approach.

    Science.gov (United States)

    Outomuro, David; Adams, Dean C; Johansson, Frank

    2013-06-07

    Wing size and shape have important aerodynamic implications on flight performance. We explored how wing size was related to wing shape in territorial males of 37 taxa of the damselfly family Calopterygidae. Wing coloration was also included in the analyses because it is sexually and naturally selected and has been shown to be related to wing shape. We studied wing shape using both the non-dimensional radius of the second moment of wing area (RSM) and geometric morphometrics. Lower values of the RSM result in less energetically demanding flight and wider ranges of flight speed. We also re-analyzed previously published data on other damselflies and dragonflies. The RSM showed a hump-shaped relationship with wing size. However, after correcting for phylogeny using independent contrast, this pattern changed to a negative linear relationship. The basal genus of the study family, Hetaerina, was mainly driving that change. The obtained patterns were specific for the study family and differed from other damselflies and dragonflies. The relationship between the RSM and wing shape measured by geometric morphometrics was linear, but relatively small changes along the RSM axis can result in large changes in wing shape. Our results also showed that wing coloration may have some effect on RSM. We found that RSM showed a complex relationship with size in calopterygid damselflies, probably as a result of other selection pressures besides wing size per se. Wing coloration and specific behavior (e.g. courtship) are potential candidates for explaining the complexity. Univariate measures of wing shape such as RSM are more intuitive but lack the high resolution of other multivariate techniques such as geometric morphometrics. We suggest that the relationship between wing shape and size are taxa-specific and differ among closely-related insect groups.

  5. Shape optimisation and performance analysis of flapping wings

    KAUST Repository

    Ghommem, Mehdi

    2012-09-04

    In this paper, shape optimisation of flapping wings in forward flight is considered. This analysis is performed by combining a local gradient-based optimizer with the unsteady vortex lattice method (UVLM). Although the UVLM applies only to incompressible, inviscid flows where the separation lines are known a priori, Persson et al. [1] showed through a detailed comparison between UVLM and higher-fidelity computational fluid dynamics methods for flapping flight that the UVLM schemes produce accurate results for attached flow cases and even remain trend-relevant in the presence of flow separation. As such, they recommended the use of an aerodynamic model based on UVLM to perform preliminary design studies of flapping wing vehicles Unlike standard computational fluid dynamics schemes, this method requires meshing of the wing surface only and not of the whole flow domain [2]. From the design or optimisation perspective taken in our work, it is fairly common (and sometimes entirely necessary, as a result of the excessive computational cost of the highest fidelity tools such as Navier-Stokes solvers) to rely upon such a moderate level of modelling fidelity to traverse the design space in an economical manner. The objective of the work, described in this paper, is to identify a set of optimised shapes that maximise the propulsive efficiency, defined as the ratio of the propulsive power over the aerodynamic power, under lift, thrust, and area constraints. The shape of the wings is modelled using B-splines, a technology used in the computer-aided design (CAD) field for decades. This basis can be used to smoothly discretize wing shapes with few degrees of freedom, referred to as control points. The locations of the control points constitute the design variables. The results suggest that changing the shape yields significant improvement in the performance of the flapping wings. The optimisation pushes the design to "bird-like" shapes with substantial increase in the time

  6. The development of a closed-loop flight controller with panel method integration for gust alleviation using biomimetic feathers on aircraft wings

    Science.gov (United States)

    Blower, Christopher J.; Lee, Woody; Wickenheiser, Adam M.

    2012-04-01

    This paper presents the development of a biomimetic closed-loop flight controller that integrates gust alleviation and flight control into a single distributed system. Modern flight controllers predominantly rely on and respond to perturbations in the global states, resulting in rotation or displacement of the entire aircraft prior to the response. This bio-inspired gust alleviation system (GAS) employs active deflection of electromechanical feathers that react to changes in the airflow, i.e. the local states. The GAS design is a skeletal wing structure with a network of featherlike panels installed on the wing's surfaces, creating the airfoil profile and replacing the trailing-edge flaps. In this study, a dynamic model of the GAS-integrated wing is simulated to compute gust-induced disturbances. The system implements continuous adjustment to flap orientation to perform corrective responses to inbound gusts. MATLAB simulations, using a closed-loop LQR integrated with a 2D adaptive panel method, allow analysis of the morphing structure's aerodynamic data. Non-linear and linear dynamic models of the GAS are compared to a traditional single control surface baseline wing. The feedback loops synthesized rely on inertial changes in the global states; however, variations in number and location of feather actuation are compared. The bio-inspired system's distributed control effort allows the flight controller to interchange between the single and dual trailing edge flap profiles, thereby offering an improved efficiency to gust response in comparison to the traditional wing configuration. The introduction of aero-braking during continuous gusting flows offers a 25% reduction in x-velocity deviation; other flight parameters can be reduced in magnitude and deviation through control weighting optimization. Consequently, the GAS demonstrates enhancements to maneuverability and stability in turbulent intensive environments.

  7. Aerodynamic Design of Integrated Propulsion-Airframe Configuration of the Hybrid Wing-Body Aircraft

    Science.gov (United States)

    Liou, May-Fun; Kim, Hyoungjin; Lee, B. J.; Liou, Meng-Sing

    2017-01-01

    Hybrid Wing Body (HWB) aircraft is characterized by a flattened and airfoil-shaped body, which produces a substantial portion of the total lift. The body form is composed of distinct and separate wing structures, though the wings are smoothly blended into the body. This concept has been studied widely and results suggest remarkable performance improvements over the conventional tube and wing transport1,2. HWB incorporates design features from both a futuristic fuselage and flying wing design, which houses most of the crew, payload and equipment inside the main centerbody structure.

  8. PET reconstruction via nonlocal means induced prior.

    Science.gov (United States)

    Hou, Qingfeng; Huang, Jing; Bian, Zhaoying; Chen, Wufan; Ma, Jianhua

    2015-01-01

    The traditional Bayesian priors for maximum a posteriori (MAP) reconstruction methods usually incorporate local neighborhood interactions that penalize large deviations in parameter estimates for adjacent pixels; therefore, only local pixel differences are utilized. This limits their abilities of penalizing the image roughness. To achieve high-quality PET image reconstruction, this study investigates a MAP reconstruction strategy by incorporating a nonlocal means induced (NLMi) prior (NLMi-MAP) which enables utilizing global similarity information of image. The present NLMi prior approximates the derivative of Gibbs energy function by an NLM filtering process. Specially, the NLMi prior is obtained by subtracting the current image estimation from its NLM filtered version and feeding the residual error back to the reconstruction filter to yield the new image estimation. We tested the present NLMi-MAP method with simulated and real PET datasets. Comparison studies with conventional filtered backprojection (FBP) and a few iterative reconstruction methods clearly demonstrate that the present NLMi-MAP method performs better in lowering noise, preserving image edge and in higher signal to noise ratio (SNR). Extensive experimental results show that the NLMi-MAP method outperforms the existing methods in terms of cross profile, noise reduction, SNR, root mean square error (RMSE) and correlation coefficient (CORR).

  9. Prior learning assessment and quality assurance practice ...

    African Journals Online (AJOL)

    The use of RPL (Recognition of Prior Learning) in higher education to assess RPL candidates for admission into programmes of study met with a lot of criticism from faculty academics. Lecturers viewed the possibility of admitting large numbers of under-qualified adult learners, as a threat to the institution's reputation, or an ...

  10. routine saline infusion sonohysterography prior to assisted ...

    African Journals Online (AJOL)

    INTRODUCTION. The outcome of assisted reproductive technique largely depends on the receptivity of the endometrial lining of the uterus. Measures aimed at evaluating the uterine cavity prior to treatment are very vital for decision making and hence contribute to the overall success rate. The true prevalence of intrauterine ...

  11. Validity in assessment of prior learning

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne; Aarkrog, Vibe

    2015-01-01

    , the article discusses the need for specific criteria for assessment. The reliability and validity of the assessment procedures depend on whether the competences are well-defined, and whether the teachers are adequately trained for the assessment procedures. Keywords: assessment, prior learning, adult...... education, vocational training, lifelong learning, validity...

  12. Sparse Multivariate Modeling: Priors and Applications

    DEFF Research Database (Denmark)

    Henao, Ricardo

    This thesis presents a collection of statistical models that attempt to take advantage of every piece of prior knowledge available to provide the models with as much structure as possible. The main motivation for introducing these models is interpretability since in practice we want to be able to...

  13. Reichenbach, Prior and Hybrid Tense Logic

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Jørgensen, Klaus Frovin

    2016-01-01

    In this paper we combine central insights of Prior and Reichenbach in the framework of hybrid tense logic. We do so in a way that overcomes a well-known defect of Reichenbach’s original tense schema, namely that it gives multiple representations to sentences in the Future perfect and the Future...... on the range of tense operators....

  14. Bactericidal Effects of Natural Nanotopography of Dragonfly Wing on Escherichia coli.

    Science.gov (United States)

    Bandara, Chaturanga D; Singh, Sanjleena; Afara, Isaac O; Wolff, Annalena; Tesfamichael, Tuquabo; Ostrikov, Kostya; Oloyede, Adekunle

    2017-03-01

    Nanotextured surfaces (NTSs) are critical to organisms as self-adaptation and survival tools. These NTSs have been actively mimicked in the process of developing bactericidal surfaces for diverse biomedical and hygiene applications. To design and fabricate bactericidal topographies effectively for various applications, understanding the bactericidal mechanism of NTS in nature is essential. The current mechanistic explanations on natural bactericidal activity of nanopillars have not utilized recent advances in microscopy to study the natural interaction. This research reveals the natural bactericidal interaction between E. coli and a dragonfly wing's (Orthetrum villosovittatum) NTS using advanced microscopy techniques and proposes a model. Contrary to the existing mechanistic models, this experimental approach demonstrated that the NTS of Orthetrum villosovittatum dragonfly wings has two prominent nanopillar populations and the resolved interface shows membrane damage occurred without direct contact of the bacterial cell membrane with the nanopillars. We propose that the bacterial membrane damage is initiated by a combination of strong adhesion between nanopillars and bacterium EPS layer as well as shear force when immobilized bacterium attempts to move on the NTS. These findings could help guide the design of novel biomimetic nanomaterials by maximizing the synergies between biochemical and mechanical bactericidal effects.

  15. The Gene Expression Program for the Formation of Wing Cuticle in Drosophila.

    Directory of Open Access Journals (Sweden)

    Lukasz F Sobala

    2016-05-01

    Full Text Available The cuticular exoskeleton of insects and other arthropods is a remarkably versatile material with a complex multilayer structure. We made use of the ability to isolate cuticle synthesizing cells in relatively pure form by dissecting pupal wings and we used RNAseq to identify genes expressed during the formation of the adult wing cuticle. We observed dramatic changes in gene expression during cuticle deposition, and combined with transmission electron microscopy, we were able to identify candidate genes for the deposition of the different cuticular layers. Among genes of interest that dramatically change their expression during the cuticle deposition program are ones that encode cuticle proteins, ZP domain proteins, cuticle modifying proteins and transcription factors, as well as genes of unknown function. A striking finding is that mutations in a number of genes that are expressed almost exclusively during the deposition of the envelope (the thin outermost layer that is deposited first result in gross defects in the procuticle (the thick chitinous layer that is deposited last. An attractive hypothesis to explain this is that the deposition of the different cuticle layers is not independent with the envelope instructing the formation of later layers. Alternatively, some of the genes expressed during the deposition of the envelope could form a platform that is essential for the deposition of all cuticle layers.

  16. The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development.

    Science.gov (United States)

    Morriss, Ginny R; Jaramillo, Carmelita T; Mikolajczak, Crystal M; Duong, Sandy; Jaramillo, Maryann S; Cripps, Richard M

    2013-11-01

    wings apart (wap) is a recessive, semilethal gene located on the X chromosome in Drosophila melanogaster, which is required for normal wing-vein patterning. We show that the wap mutation also results in loss of the adult jump muscle. We use complementation mapping and gene-specific RNA interference to localize the wap locus to the proximal X chromosome. We identify the annotated gene CG14614 as the gene affected by the wap mutation, since one wap allele contains a non-sense mutation in CG14614, and a genomic fragment containing only CG14614 rescues the jump-muscle phenotypes of two wap mutant alleles. The wap gene lies centromere-proximal to touch-insensitive larva B and centromere-distal to CG14619, which is tentatively assigned as the gene affected in introverted mutants. In mutant wap animals, founder cell precursors for the jump muscle are specified early in development, but are later lost. Through tissue-specific knockdowns, we demonstrate that wap function is required in both the musculature and the nervous system for normal jump-muscle formation. wap/CG14614 is homologous to vertebrate wdr68, DDB1 and CUL4 associated factor 7, which also are expressed in neuromuscular tissues. Thus, our findings provide insight into mechanisms of neuromuscular development in higher animals and facilitate the understanding of neuromuscular diseases that may result from mis-expression of muscle-specific or neuron-specific genes.

  17. DSMC calculations for the delta wing. [Direct Simulation Monte Carlo method

    Science.gov (United States)

    Celenligil, M. Cevdet; Moss, James N.

    1990-01-01

    Results are reported from three-dimensional direct simulation Monte Carlo (DSMC) computations, using a variable-hard-sphere molecular model, of hypersonic flow on a delta wing. The body-fitted grid is made up of deformed hexahedral cells divided into six tetrahedral subcells with well defined triangular faces; the simulation is carried out for 9000 time steps using 150,000 molecules. The uniform freestream conditions include M = 20.2, T = 13.32 K, rho = 0.00001729 kg/cu m, and T(wall) = 620 K, corresponding to lambda = 0.00153 m and Re = 14,000. The results are presented in graphs and briefly discussed. It is found that, as the flow expands supersonically around the leading edge, an attached leeside flow develops around the wing, and the near-surface density distribution has a maximum downstream from the stagnation point. Coefficients calculated include C(H) = 0.067, C(DP) = 0.178, C(DF) = 0.110, C(L) = 0.714, and C(D) = 1.089. The calculations required 56 h of CPU time on the NASA Langley Voyager CRAY-2 supercomputer.

  18. Nanomechanical properties of wing membrane layers in the house cricket (Acheta domesticus Linnaeus).

    Science.gov (United States)

    Sample, Caitlin S; Xu, Alan K; Swartz, Sharon M; Gibson, Lorna J

    2015-03-01

    Many insect wings change shape dynamically during the wingbeat cycle, and these deformations have the potential to confer energetic and aerodynamic benefits during flight. Due to the lack of musculature within the wing itself, the changing form of the wing is determined primarily by its passive response to inertial and aerodynamic forces. This response is in part controlled by the wing's mechanical properties, which vary across the membrane to produce regions of differing stiffness. Previous studies of wing mechanical properties have largely focused on surface or bulk measurements, but this ignores the layered nature of the wing. In our work, we investigated the mechanical properties of the wings of the house cricket (Acheta domesticus) with the aim of determining differences between layers within the wing. Nanoindentation was performed on both the surface and the interior layers of cross-sectioned samples of the wing to measure the Young's modulus and hardness of the outer- and innermost layers. The results demonstrate that the interior of the wing is stiffer than the surface, and both properties vary across the wing. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Effect of delta wing on the particle flow in a novel gas supersonic separator

    DEFF Research Database (Denmark)

    Wen, Chuang; Yang, Yan; Walther, Jens Honore

    2016-01-01

    The present work presents numerical simulations of the complex particle motion in a supersonic separator with a delta wing located in the supersonic flow. The effect of the delta wing on the strong swirling flow is analysed using the Discrete Particle Method. The results show that the delta wings...... re-compress the upstream flow and the gas Mach number decreases correspondingly. However, the Mach number does not vary significantly from the small, medium and large delta wing configurations. The small delta wing generates a swirl near its surface, but has minor influences on the flow above it....... On the contrary, the use of the large delta wing produces a strong swirling flow in the whole downstream region. For the large delta wing, the collection efficiency reaches 70% with 2 μm particles, indicating a good separation performance of the proposed supersonic separator....

  20. Piezoelectric energy harvesting from morphing wing motions for micro air vehicles

    KAUST Repository

    Abdelkefi, Abdessattar

    2013-09-10

    Wing flapping and morphing can be very beneficial to managing the weight of micro air vehicles through coupling the aerodynamic forces with stability and control. In this letter, harvesting energy from the wing morphing is studied to power cameras, sensors, or communication devices of micro air vehicles and to aid in the management of their power. The aerodynamic loads on flapping wings are simulated using a three-dimensional unsteady vortex lattice method. Active wing shape morphing is considered to enhance the performance of the flapping motion. A gradient-based optimization algorithm is used to pinpoint the optimal kinematics maximizing the propellent efficiency. To benefit from the wing deformation, we place piezoelectric layers near the wing roots. Gauss law is used to estimate the electrical harvested power. We demonstrate that enough power can be generated to operate a camera. Numerical analysis shows the feasibility of exploiting wing morphing to harvest energy and improving the design and performance of micro air vehicles.

  1. Adapting prior knowledge activation: Mobilisation, perspective taking, and learners' prior knowledge

    NARCIS (Netherlands)

    Wetzels, Sandra; Kester, Liesbeth; Van Merriënboer, Jeroen

    2010-01-01

    Wetzels, S. A. J., Kester, L., & Van Merriënboer, J. J. G. (2011). Adapting prior knowledge activation: Mobilisation, perspective taking, and learners’ prior knowledge [Special issue]. Computers in Human Behavior, 27(1), 16-21. doi: 10.1016/j.chb.2010.05.004

  2. Force measurements of flexible tandem wings in hovering and forward flights

    International Nuclear Information System (INIS)

    Zheng, Yingying; Wu, Yanhua; Tang, Hui

    2015-01-01

    Aerodynamic forces, power consumptions and efficiencies of flexible and rigid tandem wings undergoing combined plunging/pitching motion were measured in a hovering flight and two forward flights with Strouhal numbers of 0.6 and 0.3. Three flexible dragonfly-like tandem wing models termed Wing I, Wing II, and Wing III which are progressively less flexible, as well as a pair of rigid wings as the reference were operated at three phase differences of 0°, 90° and 180°. The results showed that both the flexibility and phase difference have significant effects on the aerodynamic performances. In both hovering and forward flights at a higher oscillation frequency of 1 Hz (St = 0.6), the Wing III model outperformed the other wing models with larger total horizontal force coefficient and efficiency. In forward flight at the lower frequency of 0.5 Hz (St = 0.3), Wing III, rigid wings and Wing II models performed best at 0°, 90° and 180° phase difference, respectively. From the time histories of force coefficients of fore- and hind-wings, different peak values, phase lags, and secondary peaks were found to be the important reasons to cause the differences in the average horizontal force coefficients. Particle image velocimetry and deformation measurements were performed to provide the insights into how the flexibility affects the aerodynamic performance of the tandem wings. The spanwise bending deformation was found to contribute to the horizontal force, by offering a more beneficial position to make LEV more attached to the wing model in both hovering and forward flights, and inducing a higher-velocity region in forward flight. (paper)

  3. DAST in Flight just after Structural Failure of Right Wing

    Science.gov (United States)

    1980-01-01

    Two BQM-34 Firebee II drones were modified with supercritical airfoils, called the Aeroelastic Research Wing (ARW), for the Drones for Aerodynamic and Structural Testing (DAST) program, which ran from 1977 to 1983. This photo, taken 12 June 1980, shows the DAST-1 (Serial #72-1557) immediately after it lost its right wing after suffering severe wing flutter. The vehicle crashed near Cuddeback Dry Lake. The Firebee II was selected for the DAST program because its standard wing could be removed and replaced by a supercritical wing. The project's digital flutter suppression system was intended to allow lighter wing structures, which would translate into better fuel economy for airliners. Because the DAST vehicles were flown intentionally at speeds and altitudes that would cause flutter, the program anticipated that crashes might occur. These are the image contact sheets for each image resolution of the NASA Dryden Drones for Aerodynamic and Structural Testing (DAST) Photo Gallery. From 1977 to 1983, the Dryden Flight Research Center, Edwards, California, (under two different names) conducted the DAST Program as a high-risk flight experiment using a ground-controlled, pilotless aircraft. Described by NASA engineers as a 'wind tunnel in the sky,' the DAST was a specially modified Teledyne-Ryan BQM-34E/F Firebee II supersonic target drone that was flown to validate theoretical predictions under actual flight conditions in a joint project with the Langley Research Center, Hampton, Virginia. The DAST Program merged advances in electronic remote control systems with advances in airplane design. Drones (remotely controlled, missile-like vehicles initially developed to serve as gunnery targets) had been deployed successfully during the Vietnamese conflict as reconnaissance aircraft. After the war, the energy crisis of the 1970s led NASA to seek new ways to cut fuel use and improve airplane efficiency. The DAST Program's drones provided an economical, fuel-conscious method for

  4. Random template placement and prior information

    International Nuclear Information System (INIS)

    Roever, Christian

    2010-01-01

    In signal detection problems, one is usually faced with the task of searching a parameter space for peaks in the likelihood function which indicate the presence of a signal. Random searches have proven to be very efficient as well as easy to implement, compared e.g. to searches along regular grids in parameter space. Knowledge of the parameterised shape of the signal searched for adds structure to the parameter space, i.e., there are usually regions requiring to be densely searched while in other regions a coarser search is sufficient. On the other hand, prior information identifies the regions in which a search will actually be promising or may likely be in vain. Defining specific figures of merit allows one to combine both template metric and prior distribution and devise optimal sampling schemes over the parameter space. We show an example related to the gravitational wave signal from a binary inspiral event. Here the template metric and prior information are particularly contradictory, since signals from low-mass systems tolerate the least mismatch in parameter space while high-mass systems are far more likely, as they imply a greater signal-to-noise ratio (SNR) and hence are detectable to greater distances. The derived sampling strategy is implemented in a Markov chain Monte Carlo (MCMC) algorithm where it improves convergence.

  5. How lizards fly: A novel type of wing in animals.

    Directory of Open Access Journals (Sweden)

    J Maximilian Dehling

    Full Text Available Flying lizards of the genus Draco are renowned for their gliding ability, using an aerofoil formed by winglike patagial membranes and supported by elongated thoracic ribs. It remains unknown, however, how these lizards manoeuvre during flight. Here, I present the results of a study on the aerial behaviour of Dussumier's Flying Lizard (Draco dussumieri and show that Draco attaches the forelimbs to the leading edge of the patagium while airborne, forming a hitherto unknown type of composite wing. The attachment of the forelimbs to the patagium suggests that that aerofoil is controlled through movements of the forelimbs. One major advantage for the lizards is that the forelimbs retain their complete range of movement and functionality for climbing and running when not used as a part of the wing. These findings not only shed a new light on the flight of Draco but also have implications for the interpretation of gliding performance in fossil species.

  6. Structural colors from Morpho peleides butterfly wing scales

    KAUST Repository

    Ding, Yong

    2009-01-01

    A male Morpho peleides butterfly wing is decorated by two types of scales, cover and ground scales. We have studied the optical properties of each type of scales in conjunction with the structural information provided by cross-sectional transmission electron microscopy and computer simulation. The shining blue color is mainly from the Bragg reflection of the one-dimensional photonic structure, e.g., the shelf structure packed regularly in each ridges on cover scales. A thin-film-like interference effect from the base plate of the cover scale enhances such blue color and further gives extra reflection peaks in the infrared and ultraviolet regions. The analogy in the spectra acquired from the original wing and that from the cover scales suggests that the cover scales take a dominant role in its structural color. This study provides insight of using the biotemplates for fabricating smart photonic structures. © 2009 American Institute of Physics.

  7. Analysis and optimization of a camber morphing wing model

    Directory of Open Access Journals (Sweden)

    Bing Li

    2016-09-01

    Full Text Available This article proposes a camber morphing wing model that can continuously change its camber. A mathematical model is proposed and a kinematic simulation is performed to verify the wing’s ability to change camber. An aerodynamic model is used to test its aerodynamic characteristics. Some important aerodynamic analyses are performed. A comparative analysis is conducted to explore the relationships between aerodynamic parameters, the rotation angle of the trailing edge, and the angle of attack. An improved artificial fish swarm optimization algorithm is proposed, referred to as the weighted adaptive artificial fish-swarm with embedded Hooke–Jeeves search method. Some comparison tests are used to test the performance of the improved optimization algorithm. Finally, the proposed optimization algorithm is used to optimize the proposed camber morphing wing model.

  8. Comments on prospects of fully adaptive aircraft wings

    Science.gov (United States)

    Inman, Daniel J.; Gern, Frank H.; Robertshaw, Harry H.; Kapania, Rakesh K.; Pettit, Greg; Natarajan, Anand; Sulaeman, Erwin

    2001-06-01

    New generations of highly maneuverable aircraft, such as Uninhabited Combat Air Vehicles (UCAV) or Micro Air Vehicles (MAV) are likely to feature very flexible lifting surfaces. To enhance stealth properties and performance, the replacement of hinged control surfaces by smart wings and morphing airfoils is investigated. This requires a fundamental understanding of the interaction between aerodynamics, structures, and control systems. The goal is to build a model consistent with distributed control and to exercise this model to determine the progress possible in terms of flight control (lift, drag and maneuver performance) with an adaptive wing. Different modeling levels are examined and combined with a variety of distributed control approaches to determine what types of maneuvers and flight regimes may be possible. This paper describes the current progress of the project and highlights some recent findings.

  9. Structural design studies of a supersonic cruise arrow wing configuration

    Science.gov (United States)

    Sobieszczanski, J.; Mccullers, L. A.; Ricketts, R. H.; Santoro, N. J.; Beskenis, S. D.; Kurtze, W. L.

    1976-01-01

    Structural member cross sections were sized with a system of integrated computer programs to satisfy strength and flutter design requirements for several variants of the arrow wing supersonic cruise vehicle. The resulting structural weights provide a measure of the structural efficiency of the planform geometry, structural layout, type of construction, and type of material including composites. The material distribution was determined for a baseline metallic structure and the results indicate that an approximate fatigue constraint has an important effect on the structural weight required for strength but, in all cases, additional material had to be added to satisfy flutter requirements with lighter mass engines with minimum fuel onboard. The use of composite materials on the baseline configuration was explored and indicated increased structural efficiency. In the strength sizing, the all-composite construction provided a lower weight design than the hybrid construction which contained composites only in the wing cover skins. Subsequent flutter analyses indicated a corresponding lower flutter speed.

  10. Gust Load Alleviation with Robust Control for a Flexible Wing

    Directory of Open Access Journals (Sweden)

    Xiang Liu

    2016-01-01

    Full Text Available Traditional methods for gust alleviation of aircraft are mostly proposed based on a specific flight condition. In this paper, robust control laws are designed for a large flexible wing with uncertainty in Mach number and dynamic pressure. To accurately describe the aeroelastic model over a large flight envelope, a nonlinear parameter-varying model is developed which is a function of both Mach number and dynamic pressure. Then a linear fractional transformation is established accordingly and a modified model order reduction technique is applied to reduce the size of the uncertainty block. The developed model, in which the statistic nature of the gust is considered by using the Dryden power spectral density function, enables the use of μ-synthesis procedures for controller design. The simulations show that the μ controller can always effectively reduce the wing root shear force and bending moment at a given range of Mach number and dynamic pressure.

  11. Pretreated Butterfly Wings for Tuning the Selective Vapor Sensing

    Science.gov (United States)

    Piszter, Gábor; Kertész, Krisztián; Bálint, Zsolt; Biró, László Péter

    2016-01-01

    Photonic nanoarchitectures occurring in the scales of Blue butterflies are responsible for their vivid blue wing coloration. These nanoarchitectures are quasi-ordered nanocomposites which are constituted from a chitin matrix with embedded air holes. Therefore, they can act as chemically selective sensors due to their color changes when mixing volatile vapors in the surrounding atmosphere which condensate into the nanoarchitecture through capillary condensation. Using a home-built vapor-mixing setup, the spectral changes caused by the different air + vapor mixtures were efficiently characterized. It was found that the spectral shift is vapor-specific and proportional with the vapor concentration. We showed that the conformal modification of the scale surface by atomic layer deposition and by ethanol pretreatment can significantly alter the optical response and chemical selectivity, which points the way to the efficient production of sensor arrays based on the knowledge obtained through the investigation of modified butterfly wings. PMID:27618045

  12. Waste Assessment Baseline for the IPOC Second Floor, West Wing

    Energy Technology Data Exchange (ETDEWEB)

    McCord, Samuel A [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Waste Management and Pollution Prevention

    2015-04-01

    Following a building-wide waste assessment in September, 2014, and subsequent presentation to Sandia leadership regarding the goal of Zero Waste by 2025, the occupants of the IPOC Second Floor, West Wing contacted the Materials Sustainability and Pollution Prevention (MSP2) team to guide them to Zero Waste in advance of the rest of the site. The occupants are from Center 3600, Public Relations and Communications , and Center 800, Independent Audit, Ethics and Business Conduct . To accomplish this, MSP2 conducted a new limited waste assessment from March 2-6, 2015 to compare the second floor, west wing to the building as a whole. The assessment also serves as a baseline with which to mark improvements in diversion in approximately 6 months.

  13. Analysis of Kinematics of Flapping Wing UAV Using OptiTrack Systems

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    Matthew Ng Rongfa

    2016-07-01

    Full Text Available An analysis of the kinematics of a flapping membrane wing using experimental kinematic data is presented. This motion capture technique tracks the positon of the retroreflective marker(s placed on the left wing of a 1.3-m-wingspan ornithopter. The time-varying three-dimensional data of the wing kinematics were recorded for a single frequency. The wing shape data was then plotted on a two-dimensional plane to understand the wing dynamic behaviour of an ornithopter. Specifically, the wing tip path, leading edge bending, wing membrane shape, local twist, stroke angle and wing velocity were analyzed. As the three characteristic angles can be expressed in the Fourier series as a function of time, the kinematics of the wing can be computationally generated for the aerodynamic study of flapping flight through the Fourier coefficients presented. Analysis of the ornithopter wing showed how the ornithopter closely mimics the flight motions of birds despite several physical limitations.

  14. Flow structure and aerodynamic performance of a hovering bristled wing in low Re

    Science.gov (United States)

    Lee, Seunghun; Lahooti, Mohsen; Kim, Daegyoum

    2017-11-01

    Previous studies on a bristled wing have mainly focused on simple kinematics of the wing such as translation or rotation. The aerodynamic performance of a bristled wing in a quasi-steady phase is known to be comparable to that of a smooth wing without a gap because shear layers in the gaps of the bristled wing are sufficiently developed to block the gaps. However, we point out that, in the starting transient phase where the shear layers are not fully developed, the force generation of a bristled wing is not as efficient as that of a quasi-steady state. The performance in the transient phase is important to understand the aerodynamics of a bristled wing in an unsteady motion. In the hovering motion, due to repeated stroke reversals, the formation and development of shear layers inside the gaps is repeated in each stroke. In this study, a bristled wing in hovering is numerically investigated in the low Reynolds number of O(10). We especially focus on the development of shear layers during a stroke reversal and its effect on the overall propulsive performance. Although the aerodynamic force generation is slightly reduced due to the gap vortices, the asymmetric behavior of vortices in a gap between bristles during a stroke reversal makes the bristled wing show higher lift to drag ratio than a smooth wing.

  15. Phasing of dragonfly wings can improve aerodynamic efficiency by removing swirl.

    Science.gov (United States)

    Usherwood, James R; Lehmann, Fritz-Olaf

    2008-11-06

    Dragonflies are dramatic, successful aerial predators, notable for their flight agility and endurance. Further, they are highly capable of low-speed, hovering and even backwards flight. While insects have repeatedly modified or reduced one pair of wings, or mechanically coupled their fore and hind wings, dragonflies and damselflies have maintained their distinctive, independently controllable, four-winged form for over 300Myr. Despite efforts at understanding the implications of flapping flight with two pairs of wings, previous studies have generally painted a rather disappointing picture: interaction between fore and hind wings reduces the lift compared with two pairs of wings operating in isolation. Here, we demonstrate with a mechanical model dragonfly that, despite presenting no advantage in terms of lift, flying with two pairs of wings can be highly effective at improving aerodynamic efficiency. This is achieved by recovering energy from the wake wasted as swirl in a manner analogous to coaxial contra-rotating helicopter rotors. With the appropriate fore-hind wing phasing, aerodynamic power requirements can be reduced up to 22 per cent compared with a single pair of wings, indicating one advantage of four-winged flying that may apply to both dragonflies and, in the future, biomimetic micro air vehicles.

  16. Computational Aerodynamic Analysis of a Micro-CT Based Bio-Realistic Fruit Fly Wing

    Science.gov (United States)

    Brandt, Joshua; Doig, Graham; Tsafnat, Naomi

    2015-01-01

    The aerodynamic features of a bio-realistic 3D fruit fly wing in steady state (snapshot) flight conditions were analyzed numerically. The wing geometry was created from high resolution micro-computed tomography (micro-CT) of the fruit fly Drosophila virilis. Computational fluid dynamics (CFD) analyses of the wing were conducted at ultra-low Reynolds numbers ranging from 71 to 200, and at angles of attack ranging from -10° to +30°. It was found that in the 3D bio-realistc model, the corrugations of the wing created localized circulation regions in the flow field, most notably at higher angles of attack near the wing tip. Analyses of a simplified flat wing geometry showed higher lift to drag performance values for any given angle of attack at these Reynolds numbers, though very similar performance is noted at -10°. Results have indicated that the simplified flat wing can successfully be used to approximate high-level properties such as aerodynamic coefficients and overall performance trends as well as large flow-field structures. However, local pressure peaks and near-wing flow features induced by the corrugations are unable to be replicated by the simple wing. We therefore recommend that accurate 3D bio-realistic geometries be used when modelling insect wings where such information is useful. PMID:25954946

  17. Time-varying wing-twist improves aerodynamic efficiency of forward flight in butterflies.

    Science.gov (United States)

    Zheng, Lingxiao; Hedrick, Tyson L; Mittal, Rajat

    2013-01-01

    Insect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads to particularly large wing deformations, making them an ideal test case for investigation of these effects. Here we use computational models derived from experiments on free-flying butterflies to understand the effect of time-varying twist and camber on the aerodynamic performance of these insects. High-speed videogrammetry is used to capture the wing kinematics, including deformation, of a Painted Lady butterfly (Vanessa cardui) in untethered, forward flight. These experimental results are then analyzed computationally using a high-fidelity, three-dimensional, unsteady Navier-Stokes flow solver. For comparison to this case, a set of non-deforming, flat-plate wing (FPW) models of wing motion are synthesized and subjected to the same analysis along with a wing model that matches the time-varying wing-twist observed for the butterfly, but has no deformation in camber. The simulations show that the observed butterfly wing (OBW) outperforms all the flat-plate wings in terms of usable force production as well as the ratio of lift to power by at least 29% and 46%, respectively. This increase in efficiency of lift production is at least three-fold greater than reported for other insects. Interestingly, we also find that the twist-only-wing (TOW) model recovers much of the performance of the OBW, demonstrating that wing-twist, and not camber is key to forward flight in these insects. The implications of this on the design of flapping wing micro-aerial vehicles are discussed.

  18. Time-varying wing-twist improves aerodynamic efficiency of forward flight in butterflies.

    Directory of Open Access Journals (Sweden)

    Lingxiao Zheng

    Full Text Available Insect wings can undergo significant chordwise (camber as well as spanwise (twist deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads to particularly large wing deformations, making them an ideal test case for investigation of these effects. Here we use computational models derived from experiments on free-flying butterflies to understand the effect of time-varying twist and camber on the aerodynamic performance of these insects. High-speed videogrammetry is used to capture the wing kinematics, including deformation, of a Painted Lady butterfly (Vanessa cardui in untethered, forward flight. These experimental results are then analyzed computationally using a high-fidelity, three-dimensional, unsteady Navier-Stokes flow solver. For comparison to this case, a set of non-deforming, flat-plate wing (FPW models of wing motion are synthesized and subjected to the same analysis along with a wing model that matches the time-varying wing-twist observed for the butterfly, but has no deformation in camber. The simulations show that the observed butterfly wing (OBW outperforms all the flat-plate wings in terms of usable force production as well as the ratio of lift to power by at least 29% and 46%, respectively. This increase in efficiency of lift production is at least three-fold greater than reported for other insects. Interestingly, we also find that the twist-only-wing (TOW model recovers much of the performance of the OBW, demonstrating that wing-twist, and not camber is key to forward flight in these insects. The implications of this on the design of flapping wing micro-aerial vehicles are discussed.

  19. A computational study on the influence of insect wing geometry on bee flight mechanics

    Directory of Open Access Journals (Sweden)

    Jeffrey Feaster

    2017-12-01

    Full Text Available Two-dimensional computational fluid dynamics (CFD is applied to better understand the effects of wing cross-sectional morphology on flow field and force production. This study investigates the influence of wing cross-section on insect scale flapping flight performance, for the first time, using a morphologically representative model of a bee (Bombus pensylvanicus wing. The bee wing cross-section was determined using a micro-computed tomography scanner. The results of the bee wing are compared with flat and elliptical cross-sections, representative of those used in modern literature, to determine the impact of profile variation on aerodynamic performance. The flow field surrounding each cross-section and the resulting forces are resolved using CFD for a flight speed range of 1 to 5 m/s. A significant variation in vortex formation is found when comparing the ellipse and flat plate with the true bee wing. During the upstroke, the bee and approximate wing cross-sections have a much shorter wake structure than the flat plate or ellipse. During the downstroke, the flat plate and elliptical cross-sections generate a single leading edge vortex, while the approximate and bee wings generate numerous, smaller structures that are shed throughout the stroke. Comparing the instantaneous aerodynamic forces on the wing, the ellipse and flat plate sections deviate progressively with velocity from the true bee wing. Based on the present findings, a simplified cross-section of an insect wing can misrepresent the flow field and force production. We present the first aerodynamic study using a true insect wing cross-section and show that the wing corrugation increases the leading edge vortex formation frequency for a given set of kinematics.

  20. Aerodynamic consequences of wing morphing during emulated take-off and gliding in birds.

    Science.gov (United States)

    Klaassen van Oorschot, Brett; Mistick, Emily A; Tobalske, Bret W

    2016-10-01

    Birds morph their wings during a single wingbeat, across flight speeds and among flight modes. Such morphing may allow them to maximize aerodynamic performance, but this assumption remains largely untested. We tested the aerodynamic performance of swept and extended wing postures of 13 raptor species in three families (Accipitridae, Falconidae and Strigidae) using a propeller model to emulate mid-downstroke of flapping during take-off and a wind tunnel to emulate gliding. Based on previous research, we hypothesized that (1) during flapping, wing posture would not affect maximum ratios of vertical and horizontal force coefficients (C V :C H ), and that (2) extended wings would have higher maximum C V :C H when gliding. Contrary to each hypothesis, during flapping, extended wings had, on average, 31% higher maximum C V :C H ratios and 23% higher C V than swept wings across all biologically relevant attack angles (α), and, during gliding, maximum C V :C H ratios were similar for the two postures. Swept wings had 11% higher C V than extended wings in gliding flight, suggesting flow conditions around these flexed raptor wings may be different from those in previous studies of swifts (Apodidae). Phylogenetic affiliation was a poor predictor of wing performance, due in part to high intrafamilial variation. Mass was only significantly correlated with extended wing performance during gliding. We conclude that wing shape has a greater effect on force per unit wing area during flapping at low advance ratio, such as take-off, than during gliding. © 2016. Published by The Company of Biologists Ltd.